US Pat. No. 10,555,600

CLEANING APPLIANCE

Dyson Technology Limited,...

15. A handle for a dental cleaning appliance, the handle being detachably connectable to a cleaning tool of the appliance, the handle comprising:a body;
a transparent panel connected to the body, the panel defining a trough-shaped recess that extends longitudinally in a longitudinal direction of the handle;
a display; and
a control circuit for activating the display,
wherein the display is located beneath the recess such that the display is viewable through the recess.

US Pat. No. 10,555,597

PHONE RING HOLDER

CASE-MATE, INC., Atlanta...

1. A holder accessory for a portable electronic device, comprising:a base portion configured for attachment to the portable electronic device, the base portion comprising a cap, a base plate, and a rail positioned between the cap and the base plate, wherein the rail is configured to rotate about a rotational axis relative to the base portion;
a gripping component pivotally mounted to the rail, wherein the gripping component is configured to pivot about a pivot axis between a storage position and a use position, wherein the pivot axis is different than the rotational axis;
a first seal positioned between the cap and the rail; and
a second seal positioned between the rail and the base plate.

US Pat. No. 10,555,596

COMBINED CARRIERS AND PROTECTIVE VESTS

Leatherback Gear, LLC, C...

1. A backpack for providing protection, the backpack comprising:a housing that is configured to be assembled as a backpack in a first configuration and deploy a protective vest in a second configuration, wherein the housing comprises a plurality of compartments including at least a first compartment and second compartment when the housing is assembled as a backpack in the first configuration;
a fastener that enables the housing to transition from the first configuration to the second configuration, wherein: (i) a structure of the housing arranged in the second configuration includes a front vest portion and a rear portion; (ii) the first compartment is located on the front vest portion or rear portion; and (iii) a structure of the backpack permits content included within the first compartment or second compartment to remain within the backpack when the housing is arranged in the second configuration;
one or more connectors that enable the front vest portion to be coupled to the rear portion in the second configuration, wherein the one or more connectors at least include:
a pair of mid-section connectors configured to connect the front vest portion to the rear portion near an individual's mid-section region in the second configuration, and
a pair of shoulder straps that connect the front vest portion to the rear portion in the second configuration; and
armor components included in the front vest portion and the rear portion, wherein the armor components are positioned to provide protection for both a portion of an individual's torso and a portion of back or posterior region when the housing is arranged in the second configuration.

US Pat. No. 10,555,593

LIP APPLICATOR CARRIER SYSTEM

1. A lip applicator carrier system comprising:a) at least one lip applicator comprising a lip applicator housing, a lip applicator housing interior, and a dermatologically acceptable topical agent located in the lip applicator housing interior and configured to be used on a human's lips; and
b) a carrier comprising a carrier housing comprising a top, a forward end, a rear end opposite the forward end, a left side, a right side opposite the left side, a substantially open bottom, at least one internal wall extending downward from the carrier housing top and defining a plurality of reservoirs, each of the plurality of reservoirs extending from the carrier housing forward end to the carrier housing rear end,
wherein the carrier further comprises a clip extending above the carrier housing top,
wherein the at least one lip applicator is removably located in a reservoir, and further wherein each reservoir comprises a top and further wherein at least one reservoir comprises a deflectable ramp extending from the top of the reservoir.

US Pat. No. 10,555,590

CARBON FORMED BODY, DRYER, AND NOZZLE

OHGI Technological Creati...

1. A carbon formed body for use to cover an outlet of a dryer, the carbon formed body comprising:a plate-like member formed from graphite; and
elongated holes extending along a spiral line as viewed in a thickness direction of the carbon formed body and penetrating through the plate-like member in the thickness direction of the carbon formed body, wherein the thickness direction of the carbon formed body is parallel to a direction of a flow of air that flows in a housing of the dryer and that is discharged from the outlet.

US Pat. No. 10,555,589

PROTECTIVE CASE FOR MOBILE ELECTRONIC DEVICE WITH STORAGE COMPARTMENT

Incipio, LLC, Irvine, CA...

1. A user-removable protective case for retaining and protecting a mobile electronic device and containing a personal item, the protective case comprising:an inner layer;
an outer layer;
a shell formed by a main body and a subpanel, at least a portion of the main body and the subpanel are sandwiched by the inner layer and the outer layer, the subpanel is coupled to the main body through a hinge, a cavity dimensioned to retain the mobile electronic device is formed by the shell;
a front cover formed by a cover panel that is positioned between the inner layer and the outer layer, the cover panel is coupled to the subpanel of the shell through a flexible spine;
a compartment dimensioned to retain the personal item is formed into the inner layer of the shell; and
an aperture positioned and dimensioned to enable the personal item contained in the compartment to be inserted into and removed from the protective case when the subpanel is hingedly rotated away from the main body.

US Pat. No. 10,555,588

ADJUSTABLE LUGGAGE TRUNK STROLLER HAVING FOLDABLE SEAT

1. A luggage trunk stroller having a foldable seat, comprisinga rod assembly, comprising a grasping part and two parallel sleeves,
wherein said grasping part has two ends separately sleeved in top ends of said parallel sleeves, said grasping part being configured to be prolonged in length or shortened in length;
wherein said parallel sleeves are combined with a front wheel set at first bottom ends of said parallel sleeves;
wherein said parallel sleeves have two rotation pivots and two support rods at two sides of said parallel sleeves separately opposite to a casing;
wherein said support rods are disposed to said rotation pivots at second top ends of said support rods separately to be swayed with a center of said rotation pivots; and
wherein said support rods are combined with a rear wheel set at second bottom ends of said support rods;
a casing,
wherein said casing is combined with said rotation pivots of said parallel sleeves at two opposite sides of said casing; and
wherein said casing is swayed with a center of said rotation pivots of said parallel sleeves to obtain a tilt angle;
a seat cushion,
wherein said seat cushion is pivotally connected to the casing; and
wherein said seat cushion is moved in a way selected from a group consisting of being swayed and extended to be used on a front surface of said casing;
and being swayed and folded to be disposed on a side of said casing; and
a seat belt,
wherein said seat belt is obtained on said front surface of said casing to fasten and safeguard an infant.

US Pat. No. 10,555,587

EXPANDABLE LUGGAGE

Travelers Club Luggage, I...

1. An expandable luggage container comprising:a first compartment;
a side cover formed on a lateral side of the first compartment, a first zipping mechanism formed around three sides of the side cover;
a second compartment coupled to the first compartment;
a top cover formed on a top side of the second compartment, a second zipping mechanism formed around three sides of the top cover; and
a retractable telescopic pull hand that is configured to be stored in a back pocket formed at a back side of the luggage container when the pull hand is completely retracted,
wherein:
a first opening of the first compartment and a second opening of the second compartment are directed to different directions;
the second compartment is collapsible by a third zipping mechanism formed between the first compartment and second compartment;
the luggage container is in a compact mode when the second compartment is collapsed and is in an expanded mode when the second compartment is expanded by unzipping of the third zipping mechanism;
the second compartment is configured to receive a small item sized to be placed in the collapsed second compartment when the top cover is open in the compact mode;
the back pocket has a fourth zipping mechanism; and
the pull hand is extended from the back pocket when the back pocket is open by the fourth zipping mechanism;
the second compartment comprises a passage formed on a back side of the second compartment;
the passage is concealed in the compact mode; and
the extended pull hand passes through the passage in the expanded mode.

US Pat. No. 10,555,586

FRAGRANCE BODY BAND

1. A band, comprising:a base, having a base first side and a base second side, further comprising a pair of lips located at opposing perimeter edges, each of the pair of lips is extending outward away from said base first side;
an outer cover, having a cover first side and a cover second side, said outer cover having a plurality of perforations boated thereon, said cover second side removably attachable to said base first side between said pair of ups;
wherein when said outer cover is removably attached to said base, an interior is defined;
wherein said interior is capable of retaining a substrate therein;
wherein said base and said outer cover comprises a flexible and resilient material;
wherein each of said plurality of perforations are in fluid and environmental communication with said interior;
a pair of first steps, each upstanding from a surface of said base first side and each located at an equidistant position from an individual lip;
a pair of second steps, each upstanding from a surface of said outer cover second side;
wherein when said outer cover is removably attached to said base, said interior is defined as an area defined between said base first side, said outer cover second side, said pair of first steps, and said pair of second steps;
wherein said outer cover and base are cylindrical-shaped;
wherein said band is configured to facilitate wearing about a limb or appendage of a person;
wherein said base is a silicone rubber compound;
and
wherein said outer cover is a silicone rubber compound.

US Pat. No. 10,555,585

FASTENER

BSN MEDICAL GmbH, Hambur...

1. A belt assembly closure for an orthosis comprising:(a) a first closure part having a pin and a first closure part connecting means adapted to connect to a belt of a belt assembly;
(b) a second closure part having:
(i) a coupling end, an opposing connection end, and a connecting line between the coupling end and the connection end,
(ii) a second closure part connecting means positioned on the connection end of the second closure part adapted to connect to another belt of the belt assembly,
(iii) an arcuate guide track positioned between the coupling end and the connection end and extending in a closure plane from an entrance opening to a guide track end and adapted to receive and guide the pin between the entrance opening and the guide track end along the guide track by movement perpendicular to the connecting line for a releasable connection between the first closure part and the second closure part,
(iv) the guide track entrance opening positioned between the connection end and the coupling end and formed on an edge of a first side of the second closure part, and
(v) another second closure part connecting means positioned on a second side of the connecting line opposing the first side adapted for another belt of the belt assembly;
(c) the pin having a first section proximate to the first closure part connecting means and a second section adjoining the first section and positioned on an end of the first section opposite the first closure part connecting means; and
(d) wherein dimensions of the first section of the pin perpendicular to the direction of extension of the pin correspond to the dimensions of the guide track in the closure plane at the guide track end, and dimensions of the second section of the pin perpendicular to the direction of extension of the pin are greater than the dimensions of the guide track at the guide track end so that the second section restricts movement of the pin relative to the second closure part perpendicular to the closure plane.

US Pat. No. 10,555,583

AUTOMATIC SHOE-LACING MACHINE AND METHOD FOR PROCESSING A SHOE UPPER

Pou Chen Corporation, (T...

1. An automatic shoe-lacing machine adapted for securing a shoelace onto a shoe upper, the shoelace having a flexible lace body, and two tipping members that are respectively connected to two opposite ends of the lace body, the shoe upper having two spaced-apart lace stay pieces, each of the lace stay pieces being formed with a plurality of spaced-apart eyelets, said automatic shoe-lacing machine comprising:a jig unit adapted to permit the shoe upper to be disposed thereon;
a robotic arm unit disposed at the proximity of said jig unit, said robotic arm unit being adapted to simultaneously hold and move the tipping members of the shoelace for sequentially passing the tipping members through the eyelets of the shoe upper; and
a control unit controlling the movement of said robotic arm unit;
wherein said robotic arm unit includes an arm module, and two spaced-apart grip modules that are connected to the arm module and that are for respectively holding the tipping members, said arm module and said grip modules being controlled by the control unit for sequentially passing the tipping members through the eyelets of the shoe upper;
wherein said arm module includes an upper arm mechanism, said grip modules being mounted to a distal end of said upper arm mechanism;
wherein said automatic shoe-lacing machine further comprising a machine vision unit that is for detecting the positions of the eyelets of the shoe upper; and
wherein said machine vision unit is operable to output a coordinate signal that is related to the position of at least one of the eyelets of the shoe upper, said control unit emitting a drive signal upon reception of the coordinate signal output from said machine vision unit, said upper arm mechanism of said arm module moving said grip modules to a designated position upon reception of the drive signal emitted from said control unit, and then returning a ready signal, said control unit emitting a lacing signal upon reception of the ready signal emitted from said upper arm mechanism, said upper arm mechanism cooperating with said grip modules for operating the shoelace upon reception of the lacing signal emitted from said control unit, and then returning a finish signal to said control unit.

US Pat. No. 10,555,582

SHOE CONSTRUCTIONS HAVING UPPER ASSEMBLIES WITH INDEPENDENTLY MOVABLE BOOTIES AND DECOUPLED SOLE ASSEMBLIES

Brooks Sports, Inc., Sea...

1. A shoe assembly, comprising:an upper having an exterior layer, an interior layer coupled to the exterior layer and defining an interior area configured to contain a foot of a wearer, and a throat portion defining an opening to the interior area;
a sole assembly coupled to the upper and configured to support the foot when positioned in the interior area, the sole assembly having a midsole and an outsole couple to a bottom portion of the midsole, the sole assembly having a forefoot region, a heel region and an arch region between the forefoot and heel regions, midsole and outsole defining a first portion in the forefoot region and a second portion in the heel region, wherein the first and second regions are separated by a space and are decoupled from each other forming a flex portion rearward of the forefoot portion between the first and second regions, wherein the interior layer of the upper forms a bootie connected to the exterior layer at the throat, wherein the bootie is independently movable relative to the sole assembly and at least a portion of the exterior layer;
a strapping assembly with at least one strap extending partially laterally around a midfoot region, an underfoot portion, and a heel portion of the bootie, wherein the at least one strap is movable relative to the bootie to tighten or loosen the bootie on the foot;
a plurality of retainers secured to the bootie, wherein the retainers slidably receive the strapping assembly such that the strapping assembly is movable with respect to the bootie and wherein the at least one strap is movable through the retainers to tighten or loosen the bootie on the foot; and
a shoe lace coupled to the exterior layer and to the strapping assembly, the shoe lace configured to move the strapping assembly relative to the bootie to tighten or loosen the bootie on the foot while within the exterior layer.

US Pat. No. 10,555,581

BRAIDED UPPER WITH MULTIPLE MATERIALS

Nike, Inc., Beaverton, O...

1. An article of footwear having a braided upper, comprising:a first group of tensile elements having a square cross-sectional shape and braided to form a first braided strand having a first cross-sectional area;
a second group of tensile elements having a circular cross-sectional shape and braided to form a second braided strand having a a second cross-sectional area;
wherein the first braided strand is different than the second braided strand; and
wherein the first braided strand oriented along a first direction is braided with the second braided strand oriented along a second direction at a bias relative to the first direction to form at least a region of the braided upper and wherein one of the first braided strand and the second braided strand is an axial component of the braided upper.

US Pat. No. 10,555,578

RAPID-ENTRY SHOE

FAST IP, LLC, Vineyard, ...

1. A rapid-entry shoe comprising:a sole having an upper surface configured to support a user's foot, an inner layer positioned below the upper surface, and two connection points, each connection point dispersed around a periphery of the sole;
an upper defining an opening adapted to receive entry of the user's foot into the shoe, the opening defining a top edge of the upper surrounding the opening;
a rear portion of the upper configured to secure the user's foot in the shoe; and
a rear flexible loop, each end thereof extending into the inner layer of the sole and directly coupled to and terminating at its respective connection point in the sole and operatively attached to the rear portion, wherein the rear flexible loop is configured to have a native position in which the rear flexible loop holds the rear portion of the shoe in a closed position securing the user's foot in the shoe and wherein the rear flexible loop may be deformed by an opening force to open the shoe to permit rapid entry of the user's foot into the shoe,
the rear flexible loop comprising at least one deformable element,
the rear flexible loop further comprising a rear bending portion extending around the rear portion of the upper, and
wherein, in response to the opening force, the rear bending portion is configured to flex independent of the at least one deformable element; wherein the at least one deformable element extends continuously from its respective connection point to the rear bending portion, the rear bending portion being positioned both rearward of the connection points and proximal the top edge of the upper of the rear portion.

US Pat. No. 10,555,577

MASSAGING BOOT ASSEMBLY

1. A massaging boot assembly being configured to massage a foot, said assembly comprising:a boot being configured to be worn on a foot, said boot having a vamp, a counter, a sole, a front quarter and a back quarter, each of said front quarter and said back quarter having a distal edge with respect to said sole to define an opening in the said boot, said boot having a cut extending between said distal edge and said sole to divide said front quarter from said back quarter;
a string being laced between each of said front quarter and said back quarter, said string being aligned with and being coextensive with said cut such that said string selectively closes said cut when said string is tightened;
a massage unit being coupled to said boot wherein said massage unit is configured to massage the foot when said boot is worn, said massage unit being selectively turned on and off, said massage unit comprising a plurality of motors, each of said motors being positioned within said boot, said motors being spaced apart from each other and being distributed along said vamp, said counter, said sole, said front quarter and said back quarter, each of said motors being electrically coupled together to form an array of motors;
a first power button being coupled to said boot wherein said power button is configured to be manipulated, said power button being electrically coupled to said array of motors such that said power button turns said array of motors on and off; and
a heating unit being coupled to said boot such that said heating unit is in thermal communication with said boot, said heating unit being selectively turned on wherein said heating unit is configured to selectively heat the foot thereby enhancing therapeutic relief of the foot, said heating unit comprising a plurality of heating elements, each of said heating elements being positioned within said boot such that each of said heating elements is in thermal communication with said boot, said heating elements being spaced apart from each other and being distributed on said vamp, said counter, said front quarter and said back quarter.

US Pat. No. 10,555,576

PROTECTIVE HOOD MADE FROM MATERIALS OF VARIABLE STRETCH KNIT AND WOVEN TEXTILES

HONEYWELL INTERNATIONAL I...

15. A protective hood for use by a firefighter or other emergency worker, the hood comprising:a crown portion to cover a top of a wearer's head;
a head portion that extends downward from the crown portion to cover at least sides and back of the wearer's head, the head portion comprising one or more layers of a first woven material;
a face opening defined by an aperture in a front of the head portion, the face opening defined at least in part by a first edge of an innermost band encircling the face opening, the innermost band comprising a one or more layers of a first knit material disposed about an elastic member;
a brow band coupled along a first edge to a second edge of the innermost band, the brow band comprising one or more layers of a second knit material;
a woven band coupled along a first edge to a second edge of the brow band, the brow band coupled along a second edge to the head portion, the woven band comprising one or more layers of a second woven material; and
a front drape and a rear drape, both of the front drape and the rear drape coupled to and extending in a downward direction from the head portion to cover at least a portion of a neck and shoulders of the wearer.

US Pat. No. 10,555,571

BODYBUILDING COMPETITION SUIT NUMBERS TAB

6. A system for connecting a number sheet to a competition suit, comprising:a competition suit of a predetermined stretch material having a bottom portion, wherein the bottom portion is adapted to be worn around a waist of a human wearer;
an attachment point provided by the bottom portion, wherein the attachment point is located adjacent to an upper left hand side of a front portion of the waist of the human wearer when the bottom portion is worn; and
a number sheet having an elongated pin connector;
a tubular tab attached at the attachment point;
the tubular tab shaped from the predetermined stretch material to define a lumen having an inner periphery related to a length of the elongated pin connector so that the elongated pin connector may be woven in and out of the tubular tab before closing the elongated pin connector,
whereby the number sheet can be securely pinned indirectly to the competition suit without damaging the competition suit.

US Pat. No. 10,555,569

VOLUNTARY TEMPORARY HAND RESTRAINT GLOVE TO REDUCE A WEARERS ABILITY TO EFFECTIVELY HOLD OR USE A WEAPON

1. A device, comprising:a main body providing a thumb cavity, an index cavity, and a first cavity;
the thumb cavity dimensioned to receive an extended thumb of a human wearer;
the index cavity dimensioned to receive an extended index finger of the human wearer;
the first cavity dimensioned to receive a third finger, a fourth finger and a fifth finger of the human wearer in a first configuration;
the first cavity extending from a wrist opening to an opposing distal boundary, wherein the first cavity is enclosed at said distal boundary;
the index cavity extends beyond said distal boundary and a distal end of the thumb cavity, wherein only the index cavity extends from said distal boundary; and
a webbing extending between the index cavity and the thumb cavity.

US Pat. No. 10,555,567

PROTECTIVE PAD SYSTEMS AND METHODS

1. An apparatus for preventing hyper-flexion of a joint comprising:(a) a sleeve having a first end and a second end and a first portion and a second portion;
(b) a first pad associated with the first portion of the sleeve, wherein the first pad is retained within a first covering and is selectively removable from the first covering;
(c) a second pad associated with the second portion of the sleeve, the second pad being retained within a second covering, wherein the first pad is spaced apart from the second pad by a distance;
(d) an angle of engagement, wherein the angle of engagement is a predetermined angle at which the first pad engages the second pad to resist further motion and to prevent hyper-flexion of the joint; and
wherein the first pad retained within the first covering is selectively replaceable with a first alternate pad.

US Pat. No. 10,555,563

HYBRID APPAREL AND METHOD OF TRANSFORMING SAME INTO OTHER GARMENT TYPES

1. A multipurpose customizable garment comprising:a first detachable element having a first plurality of fasteners;
a second detachable element having a second plurality of fasteners, wherein the first detachable element is a first detachable sleeve, the second detachable element is a second detachable sleeve, wherein at least one of the first detachable sleeve and the second detachable sleeve is convertible into a second multipurpose customizable garment, by detachably connecting the first detachable sleeve to the second detachable sleeve selectively using at least one of the first plurality of fasteners and the second plurality of fasteners such that: (a) each of at least one end of the first detachable sleeve and of at least one end of the second detachable sleeve serves as a neckline of the second multipurpose customizable garment, (b) each of at least one other end of the first detachable sleeve and of at least one other end of the second detachable sleeve serves as hem of the second multipurpose customizable garment, (c) each of at least one top edge of the first detachable sleeve and of at least one top edge of the second detachable sleeve serves as a first sleeve of the second multipurpose customizable garment, and (d) each of at least one bottom edge of the first detachable sleeve and of at least one bottom edge of the second detachable sleeve serves as a second sleeve of the second multipurpose customizable garment.

US Pat. No. 10,555,562

GARMENT FOR BREAST SUPPORT

1. A garment that provides support to breasts on a person comprising:an upper portion with breast cups, the upper portion comprising:
a back panel, front panels, and outer breast panels, each one of the front panels structurally functions both as an inner breast panel and a front strap and each one of the front panels is comprised of a single fabric piece; each one of the outer breast panels is comprised of a double fabric piece and connects to the back panel via an outer breast panel/back panel interface; at least one inner breast panel and at least one outer breast panel are connected by a curved seam to form at least one breast cup; whereby each breast cup directs a breast volume forward and supports the breast volume from an outside of a breast to an inside of the breast.

US Pat. No. 10,555,561

ATHLETIC GARMENT WITH INTEGRAL CUP ASSEMBLY

Shock Doctor, Inc., Foun...

1. An athletic garment comprising:an upper portion having a front and a rear, a first side and a second side, an interior and an exterior, and a waistband, the upper portion being configured to receive a waist of a user;
a first leg portion extending downwardly from the upper portion and configured to receive a first leg of the user;
a second leg portion extending downwardly from the upper portion and configured to receive a second leg of the user;
a pocket disposed in the interior of the upper portion, the pocket having a first side, a second side, a top, and a bottom, and narrowing in width from the top to the bottom, the first and second sides of the pocket being partially secured to the front of the upper portion within the interior of the upper portion such that the bottom of the pocket is freely suspended from the front of the upper portion; and
an elongated member extending from the bottom of the pocket to the rear of the upper portion, wherein the elongated member forms a “Y”-shape with a first end of the elongated member corresponding to a bottom of the “Y”-shape, the first end of the elongated member directly attaching to the bottom of the pocket and extending therefrom toward the rear of the upper portion, and the elongated member branching into a second end corresponding to a top of the “Y”-shape, the second end terminating and directly attaching to the rear of the upper portion at a first location spaced apart from the waistband and terminating and directly attaching to the rear of the upper portion at a second location spaced apart from the waistband.

US Pat. No. 10,555,558

AEROSOL DELIVERY DEVICE PROVIDING FLAVOR CONTROL

RAI Strategic Holdings, I...

1. An aerosol delivery device, comprising:a control body;
a cartridge, comprising:
a reservoir tank configured to contain an aerosol precursor composition;
a masking disc proximate the aerosol precursor composition, the masking disc including an opening configured to the permit aerosol precursor composition to pass therethrough; and
a flavor disc proximate the masking disc, the flavor disc including two or more separate sections, wherein at least two of the sections are configured to permit the aerosol precursor composition to pass therethrough, and at least one of the sections comprises a flavor section that contains a flavorant; and
an atomizer configured to receive the aerosol precursor composition and produce an aerosol,
wherein at least one of the masking disc or the flavor disc is configured to be rotated relative to the other to align the opening of the masking disc with a selected section of the flavor disc so as to allow the aerosol precursor composition to flow from the reservoir tank through the opening of the masking disc and the selected section of the flavor disc to the atomizer such that, when the flavor section is selected, the flavorant is imparted to the aerosol precursor composition delivered to the atomizer.

US Pat. No. 10,555,554

SIMULATED CIGARETTE

KIND CONSUMER LIMITED, L...

1. A simulated cigarette having a generally cylinder-shaped cylindrical cigarette like housing with a main axis corresponding to a cylindrical axis of the cylinder shape, the housing containing a reservoir of a pressurized pressurised inhalable composition extending along a substantial portion of the housing, the reservoir having a reservoir outlet at one end which is selectively closed by an outlet valve, the outlet valve being operable to allow the composition to flow from the reservoir outlet to an inhalation outlet at the outlet end of the device; wherein the simulated cigarette further comprises a tube with a through bore extending along a substantial portion of the reservoir from the vicinity of the reservoir outlet such that composition flows into a tube bore inlet and along the tube bore to the reservoir outlet, a tube inlet end being retained such that the main axis passes through the inlet end and so that the tube bore inlet is positioned in the axial sense in the central 50% of the volume of the reservoir.

US Pat. No. 10,555,551

TOBACCO ARTICLES AND METHODS

U.S. Smokeless Tobacco Co...

1. A method of introducing noncombusted tobacco, a noncombusted tobacco constituent or both noncombusted tobacco and a noncumbusted tobacco constituent into air, the method comprising:exposing to the atmosphere a first end portion and a second end portion of a tobacco article, the tobacco article comprising a substantially cylindrical body and tobacco, the substantially cylindrical body including a porous matrix and an outer shell surface substantially impermeable to migration of tobacco constituents, the porous matrix defining a frusto-conical channel therein, the outer shell surface at least partially surrounding the porous matrix, the tobacco being disposed in pores of the porous matrix, and the porous matrix being integrally formed with the outer shell surface; and
introducing noncombusted tobacco, a noncombusted tobacco constituent, or both noncombusted tobacco and a noncombusted tobacco constituent into air by passing the air through the pores of the porous matrix and over the tobacco disposed in the pores.

US Pat. No. 10,555,549

ROASTING DRUM OF ROASTER

1. A roasting drum comprising:a main body having
a rotating axis;
a first end;
a second end disposed opposite the first end of the main body along the rotating axis of the main body; and
multiple drums disposed along the rotating axis of the main body, mounted around one another in sequence, fastened to one another, and communicating with one another;
each one of the multiple drums having
an inner surface; and
a blending blade formed on the inner surface;
the blending blade being spiral and extending from the first end of the main body toward the second end of the main body;
the blending blade of one of the multiple drums spirally extends along a clockwise direction from the first end of the main body toward the second end of the main body;
the blending blade of another one of the multiple drums disposed within said one of the multiple drums that has the blending blade extending along the clockwise direction and spirally extending along a counter-clockwise direction from the first end of the main body toward the second end of the main body; and
at least one opening disposed on the main body; wherein
the multiple drums of the main body are two in amount;
the two drums are a first drum and a second drum;
the first drum has
a first inner surface; and
a first blending blade fixed on the first inner surface of the first drum; and
a first space disposed inside the first drum;
the second drum is mounted around the first drum and has
a second inner surface; and
a second blending blade fixed on the second inner surface of the second drum; and
a second space disposed between the first drum and the second drum; and
the first blending blade has two opposite terminal ends;
the first drum has
an entrance defined through the first inner surface of the first drum and communicating with the first space of the first drum and the second space of the second drum; and
an exit defined through the first inner surface of the first drum and communicating with the first space of the first drum and the second space of the second drum;
the entrance and the exit are respectively adjacent to the two opposite terminal ends of the first blending blade.

US Pat. No. 10,555,548

OZONE GENERATOR METHODS FOR RETROFIT OF ENCLOSED AND AIR-CONDITIONED ENVIRONMENTS

Quail Systems, LLC, Adam...

1. A method of operating a conditioned airflow ozone generator in an enclosed airspace in a previously existing conditioned airflow to extend produce and other foods shelf-life after shipment, the method comprising:sterilizing an enclosed airspace lacking produce and other foods with a conditioned airflow ozone generator placed in a previously existing conditioned airflow within the enclosed airspace, where the enclosed airspace maintains from 4 to 8 ppm ozone for a time period from 10 to 20 minutes;
placing produce and other foods within the enclosed air space;
disinfecting the produce and other foods within the enclosed airspace with the conditioned airflow ozone generator placed in the previously existing conditioned airflow, where the enclosed airspace maintains from 2 to 3.9 ppm ozone for a time period from 15 minutes to 2 hours; and
managing the produce and other foods within the enclosed airspace with the conditioned airflow ozone generator during transport of the produce and other foods, where the enclosed airspace maintains from 0.5 to 1.5 ppm ozone for a time period after termination of the disinfecting.

US Pat. No. 10,555,547

MEAT DEWATERING ASSEMBLY

Wenger Manufacturing Inc....

1. A meat dewatering assembly, comprising:a pair of elongated, non-parallel, tapered and intermeshed helically flighted screws, each screw presenting a longitudinal axis, said screws oriented with the included angle between the longitudinal axes thereof being from about 1-7°, the helical fighting of the screws cooperatively presenting nip clearances along the length of the screws;
an elongated housing at least partially surrounding said helical screws with an entrance opening for emulsified meat, a series of water outlets along at least a part of the length of the housing, and a dewatered meat outlet,
the rear end of said screws located adjacent said housing entrance, and the front end of said screws located adjacent said dewatered meat outlet, the pitch length of the helical fighting of said screws decreasing along the length of the screws between said rear and front ends;
a drive operably coupled with said screws in order to counter-rotate the screws during operation of the dewatering assembly; and
said housing configured so that as meat traverses the length of the housing the pressure within the housing is substantially atmospheric.

US Pat. No. 10,555,545

FROZEN BEVERAGE MACHINE VALVING

Taylor Commercial Foodser...

1. A dispensing apparatus (20; 300; 400) comprising:a freezing cylinder (40);
a water flowpath (526);
a first controllable valve (130) along the water flowpath;
a syrup flowpath (528), merging with the water flowpath and proceeding as a water/syrup flowpath (552) to the freezing cylinder;
a second controllable valve (132) along the syrup flowpath; and,
a carbon dioxide flowpath (572, 574) merging with the water/syrup flowpath, the carbon dioxide flowpath comprises a branch (576) extending to the water/syrup flowpath and the freezing cylinder,
wherein the first controllable valve and the second controllable valve each comprise:
a valve body (144; 432) having a cartridge compartment (164,166), an inlet (176) to the cartridge compartment, and an outlet (178) from the cartridge compartment; and
a valve cartridge (162) having a unitary construction so as to allow removal from the valve compartment and replacement as a unit, the valve cartridge comprising:
a cartridge body (200) mounted in the cartridge compartment and having a valve seat;
a valve element (222) carried by the cartridge body and having a head shiftable between a first condition disengaged from the valve seat and permitting communication between the inlet and the outlet and a second condition engaged to the valve seat and blocking communication between the inlet and the outlet; and,
a solenoid (224) carried by the cartridge body and coupled to the valve element to drive movement of the valve element.

US Pat. No. 10,555,542

METHODS OF SEPARATING FAT FROM NON-SOY PLANT MATERIALS AND COMPOSITIONS PRODUCED THEREFROM

Specialty Protein Produce...

1. A centrifugal fat separation method of processing a non-soy plant material to produce an insoluble fiber fraction, a reduced-fat plant extract and a fat-enriched fraction, comprising:a) milling the non-soy plant material to form a flour, wherein the flour has a particle size of 100 to 1000 mesh, wherein the non-soy plant material is milled using a hammer mill, roller mill or screw-type mill and wherein the non-soy plant material is substantially full fat and has a fat content of at least 30% by weight;
b) aqueously extracting the flour at a temperature between about 80° F. and 200° F. to produce a first extract, wherein the aqueous extraction is performed without promoting emulsification;
c) centrifugally separating the fat and protein in the first extract at a temperature between about 120° F. and 180° F. using a three phase separator to produce an insoluble fiber fraction, a fat-enriched fraction, and a reduced-fat plant extract, the reduced-fat plant extract having 15% or less fat by weight, and
wherein the protein to fat ratio of the reduced-fat plant extract is at least 3 to 1, and
wherein the non-soy plant material is selected from the group consisting of canola (rapeseed), castor bean, cottonseed, flaxseed, palm kernel, linseed, candlenut, sesame seed, peanut, peanut meal, coconut, corn, corn germ, sunflower, safflower, oats, rice bran, almond, hemp seed, mustard seed, wheat and wheat germ.

US Pat. No. 10,555,540

FISH DECAPITATING APPARATUS AND A METHOD FOR DECAPITATING FISH

1. A fish decapitating apparatus, comprising:a fish holder configured to receive a fish at an in-feed station;
at least one cutting station;
a conveying apparatus configured to convey the fish in said fish holder, from the in-feed station, to said at least one cutting station;
wherein the fish holder comprises opposingly arranged guide members moveable in a hinge like manner in relation to each other;
said guide members being configured to clamp the fish head behind the collar bones such that the collar bones are resting on an outer side of said guide members from which the fish head sticks out from the fish holder, the fish decapitating apparatus further comprising:
a measuring unit configured to measure the position of the collar bones when said collar bones are resting on the outer side of said guide members; and
a control unit configured to, in accordance with said measured position of the collar bones, automatically adjust the position of said at least one cutting station.

US Pat. No. 10,555,539

CUTTING DEVICE AND A CUTTING SYSTEM FOR CUTTING FOOD PRODUCTS

MAREL ICELAND EHF, Garda...

1. A cutting device for cutting a food product that is conveyed by a conveyor means, the cutting device comprising:a first cutting blade;
a moving mechanism attached to said first cutting blade for moving the first cutting blade sideways in either direction across the conveyor means; and
a control unit;wherein said first cutting blade is adapted to cut at least one incision in the product from one side of the product;wherein said control unit is adapted to control said first cutting blade and said moving mechanism based on image data of said food product, including utilizing said image data in instructing said moving mechanism to adjust the position of said first cutting blade across said conveyor means;wherein the cutting device further comprises a second cutting blade adapted to cut at least one incision in the product from a side opposite to the side of the first cutting blade, and where the control unit is further adapted to control the second cutting blade.

US Pat. No. 10,555,536

CROP FORTIFICATION, NUTRITION AND CROP PROTECTION COMPOSITION

1. A water dispersible granular composition comprising at least one algae and at least one of agrochemical excipient comprising at least one or more of surfactant, binder or disintegrant wherein, the weight ratio of algae to at least one of surfactant, binder or disintegrant is 99:1 to 1:99 wherein the algae comprises 0.1% to 90% by weight of the total composition, andwherein the composition has a particle size in the range of 0.1 microns to 60 microns.

US Pat. No. 10,555,526

SUBSTITUTED OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

BASF SE, Ludwigshafen am...

1. A method for combating phytopathogenic harmful fungi, which process comprises treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of formula I
or an N-oxide, or an agriculturally acceptable salt thereof,
wherein:
A is phenyl or a 5- or 6-membered aromatic heterocycle, wherein the ring member atoms of the aromatic heterocycle include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from N, O and S as ring member atoms; and wherein the cyclic groups A are unsubstituted or substituted by 1, 2, 3 or 4 identical or different groups RA; wherein
RA is halogen, cyano, diC1-C6-alkylamino, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl or C3-C8-cycloalkoxy; and wherein any of the aliphatic or cyclic moieties are unsubstituted or substituted by 1, 2, 3, 4 or up to the maximum possible number of identical or different groups Ra; wherein
Ra is halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio or C3-C8-cycloalkyl or C1-C4-alkoxy-C1-C4-alkyl;
L is —C(?O)—, —C(?S)-or—S(?O)p—;
p is 0, 1 or 2;
R1, R2 independently of each other are hydrogen, C1-C6-alkyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, C3-C8-cycloalkenyl, —C(?O)—(C1-C6-alkyl), —C(?O)—(C1-C6-alkoxy), C1-C6-alkoxyimino-C1-C4-alkyl, C2-C6-alkenyloxyimino-C1-C4-alkyl, C2-C6-alkynyloxyimino-C1-C4-alkyl, aminocarbonyl-C1-C6-alkyl, C3-C6-cycloalkyl-C1-C4-alkyl, phenyl-C1-C4-alkyl, heteroaryl-C1-C4-alkyl, heterocyclyl-C1-C4-alkyl, phenyl, naphthyl or a 3- to 10-membered saturated, partially unsaturated or aromatic mono- or bicyclic heterocycle, wherein the ring member atoms of said mono- or bicyclic heterocycle include besides carbon atoms further 1, 2, 3 or 4 heteroatoms selected from N, O and S as ring member atoms and wherein 1 or 2 carbon ring member atoms of the heterocycle may be replaced by 1 or 2 groups independently selected from C(?O) and C(?S); and wherein the heteroaryl group in heteroaryl-C1-C4-alkyl is a 5- or 6-membered aromatic heterocycle, wherein the ring member atoms of the heterocyclic ring include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from N, O and S as ring member atoms; and wherein the heterocyclyl group in heterocyclyl-C1-C4-alkyl is a 3- to 10-membered saturated, partially unsaturated mono- or bicyclic heterocycle, wherein the ring member atoms of said mono- or bicyclic heterocycle include besides carbon atoms further 1, 2, 3 or 4 heteroatoms selected from N, O and S as ring member atoms and wherein 1 or 2 carbon ring member atoms of the heterocycle may be replaced by 1 or 2 groups independently selected from C(?O) and C(?S); and wherein any of the aliphatic or cyclic groups are unsubstituted or substituted by 1, 2, 3, 4 or up to the maximum possible number of identical or different groups R1a;
or R1 and R2 together with the nitrogen atom to which they are bound form a saturated or partially unsaturated mono- or bicyclic 3- to 10-membered heterocycle, wherein the heterocycle includes beside one nitrogen atom and one or more carbon atoms no further heteroatoms or 1, 2 or 3 further heteroatoms independently selected from N, O and S as ring member atoms; and wherein one or two CH2 groups of the heterocycle may be replaced by one or two groups independently selected from the group of C(?O) and C(?S); and wherein the heterocycle is unsubstituted or carries 1, 2, 3, 4 or up to the maximum possible number of identical or different groups R1a; wherein
R1a is halogen, cyano, OH, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, —NHSO2—C1-C4-alkyl, —(C?O)—C1-C4-alkyl, —C(?O)—C1-C4-alkoxy, C1-C6-alkylsulfonyl, hydroxyC1-C4-alkyl, —C(?O)—NH2, —C(?O)—NH(C1-C4-alkyl), C1-C4-alkylthio-C1-C4-alkyl, aminoC1-C4-alkyl, C1-C4-alkylamino-C1-C4-alkyl, diC1-C4-alkylamino-C1-C4-alkyl, aminocarbonyl-C1-C4-alkyl or C1-C4-alkoxy-C1-C4-alkyl;
R3, R4 independently of each other are hydrogen, halogen, cyano or C1-C6-alkyl; or
R3 and R4 together with the carbon atom to which they are bound form a vinyl group or a saturated, monocyclic 3- to 5-membered heterocycle or carbocycle, wherein the heterocycle includes beside carbon atoms 1 or 2 heteroatoms independently selected from N, O and S as ring member atoms; and wherein the vinyl group, the heterocycle or the carbocycle is unsubstituted or carries 1, 2, 3, 4 or up to the maximum possible number of identical or different groups R3a; wherein
R3a is halogen, cyano or C1-C2-alkyl.

US Pat. No. 10,555,521

DISPOSABLE WIPES FOR OPTIONAL DISINFECTION, DEODORIZATION, AND/OR STERILIZATION AND METHODS OF USE THEREOF

Micrulia LLC, Salt Lake ...

1. An apparatus, comprising:a wipe, comprising:
a first substrate comprising a flexible membrane;
a first chemical element, compound, or reactive substance associable with, or carried by, said first substrate;
a second chemical element, compound, or reactive substance associable with, or carried by, said first substrate, wherein:
said first substrate is structured to carry a treatment agent comprising Hydroxyl radicals formed as a product of a chemical reaction resulting from combination of said first chemical element, compound, or reactive substance and said second chemical element, compound, or reactive substance at the time of use, and at the location of use, of said first substrate to deodorize, disinfect, and/or sterilize an object; in combination with:
a holder structured to removably couple with said wipe to permit manipulation of said wipe by said holder for disinfecting, deodorizing, and/or sterilizing a surface with said wipe, and to impart an electrical charge onto said first substrate, wherein:
said first substrate carries a biocidal compound or element; and
said holder comprises a power source and circuitry structured to cause generation of areas of positive and negative electrical charge in said wipe, the power source being untethered to permit untethered operation of said wipe, the areas of positive and negative charge to attract respective gram negative and gram positive bacteria.

US Pat. No. 10,555,518

DECOY TETHERING DEVICE

1. A decoy tethering device comprising:a housing defining an interior space, said housing being disc shaped;
a line selectively extensible from and retractable into said housing, said line extending through a hole positioned in a sidewall of said housing;
a fastener selectively couplable to said line;
a coupler coupled to said housing, said coupler being configured for coupling to a keel of a decoy, said coupler comprising
an extension coupled to and extending from said sidewall of said housing,
a first arm coupled to and extending from said extension distal from said housing, said first arm being arcuate,
a second arm pivotally coupled to and extending from said extension distal from said housing, said second arm being complementary to said first arm,
a lock coupled to said extension, said lock being operationally coupled to said second arm, and
wherein said second arm is positioned for selectively pivoting to an open configuration such that said coupler is configured for inserting a ring coupled to the keel, and a closed configuration, wherein said first arm and said second arm are loopedly positioned through the ring for coupling said housing to the decoy, wherein said lock is positioned on said extension such that said lock is positioned for retaining said second arm in the closed configuration wherein said first arm and said second arm are loopedly positioned through the ring for coupling said housing to the decoy;
a connector coupled to a second end of said line, said connector being configured for coupling to a weight; and
wherein said fastener is positioned on said line such that said fastener is positioned for decoupling from said line for extending and retracting said line from said housing and for coupling to said line for retaining said line in an extended configuration, wherein said coupler is positioned on said housing such that said coupler is configured for coupling said housing to the keel of the decoy, wherein said connector is positioned on said line such that said connector is configured for coupling to the weight positioning the weight for retaining the decoy in place on a surface of a body of water in which the weight is positioned.

US Pat. No. 10,555,517

SPRAYING UNIT, COMPACT SPRAYING MODULE INCLUDING SUCH A UNIT, AND SPRAYING AND CONTROL SYSTEM INCLUDING A PLURALITY OF SUCH MODULES

PELLENC SAS, Pertuis (FR...

1. A spraying unit for the spraying of a liquid in droplet form for the treatment of a target, the spraying unit comprising:an exhaust nozzle formed by a pipe that extends along a longitudinal axis by delimiting on the inside a main inner space and being open at ends thereof to form an air inlet opening and an air outlet opening, the main inner space accommodating
at least one rotary atomizer mounted in rotation around a first axis of rotation,
a transport system configured to transport the liquid, coming from a supply system with a controlled variable flow rate, up to the rotary atomizer,
a fan that comprises at least one propeller mounted in rotation around a second axis of rotation enabling generation of a stream of carrier air in the main inner space toward and beyond the air outlet opening, and
an electric motor drive system enabling driving in rotation of said rotary atomizer and the at least one propeller,
said rotary atomizer comprising
a receiving surface configured to receive the liquid and configured to, on a periphery thereof or an end thereof, in a state of rotation of said rotary atomizer, break up the liquid into droplets and propel the droplets into the stream of carrier air and not onto an inner wall of the exhaust nozzle, the receiving surface of the rotary atomizer exclusively breaking up the liquid into the droplets, and
a connector configured to connect to an electrical energy generator to provide electrical energy to the drive system; and
an inner fuselage that has an aerodynamic profile defined by a lateral surface delimiting on the inside a secondary inner space and being kept axially in the main inner space between the fan and the air outlet opening to define, between the fuselage and the exhaust nozzle, an annular channel for circulation of the stream of carrier air surrounding said fuselage, the fuselage comprising a rotary section that is formed by the rotary atomizer such that the periphery or the end of the receiving surface essentially is part of the lateral surface of the fuselage while enabling the rotation of the rotary atomizer and the propulsion, essentially perpendicular to the longitudinal axis, of the droplets in said channel to be incorporated in the air stream.

US Pat. No. 10,555,516

BAIT CUTTING AND CRAB MEASURING APPARATUS

1. A bait cutting and crab measuring apparatus comprises:a bait-cutting channel;
a crab-measuring panel;
the bait-cutting channel comprises a first wall, a second wall, a base panel, a first plurality of segment cuts, and a second plurality of segment cuts;
the crab-measuring panel comprises a third face, a fourth face, a proximal edge, and a distal edge;
the base panel comprises a first face and a second face;
the first wall and the second wall being connected perpendicular to the first face;
the first wall and the second wall being positioned opposite to each other across the first face;
the first plurality of segment cuts traversing through the first wall, towards the base panel;
the first plurality of segment cuts being distributed along the first wall;
the second plurality of segment cuts traversing through the second wall, towards the base panel;
the second plurality of segment cuts being distributed along the second wall;
the proximal edge being connected adjacent to the base channel; and
the crab-measuring panel being positioned coplanar to the base panel.

US Pat. No. 10,555,515

ADJUSTABLE FISHING FLOAT

1. An adjustable fishing float comprising:a first female portion having an open end providing access into a cavity thereof, the cavity having a bottom opposite the open end, wherein (1) the first female portion is constructed of a rigid material, (2) the cavity is cylindrical and has a constant inside diameter, and (3) the first female portion has a narrowed portion adjacent the open end, wherein the narrowed portion has a diameter that is smaller than the diameter of the cavity;
a second male portion having a cylindrical configuration with an outside diameter that is larger than the diameter of the narrowed portion adjacent the open end of the first female portion so that it is sized to fit through and be squeezed by the narrowed portion adjacent the open end of the first portion, the second portion inserted into the first female portion defining an air space between an inner end of the second male portion and the bottom of the first female portion, the air space providing a buoyancy to the float, the second male portion having a unitary, single-piece construction, the second male portion having a solid, cylindrical configuration extending along a longitudinal axis, and the second male portion being constructed of foam, the foam second portion being resilient and deformable, and adapted to being twisted during insertion into the first female portion such that it deforms and its outside diameter temporarily is reduced to permit air to pass through the open end of the first female portion and into and out of the air space;
the first female and second male portions defining a water resistant seal adjacent the open end to prevent water from entering the air space;
the second male portion being reusably, adjustably slidable back and forth into and out of the first female portion to permit the re-adjustable alternation of size of the air space and air volume displaced by the float to change the buoyancy of the float;
wherein the second male portion has a nose with a width smaller than the outside diameter of the second male portion and a length extending along the longitudinal axis of the second male portion and protruding from a side of the second male portion in a radial direction with respect to the longitudinal axis of the second male portion;
wherein said narrowed portion adjacent the open end of the first female portion engages and squeezes a resilient deformable outer surface of the second male portion, including the nose: (1) coupling the second male portion to the first female portion, (2) sealing the air space and resisting intrusion of water, and (3) venting air out of the air space as the second male portion is moved into the cavity while twisting the second male portion and deforming the nose.

US Pat. No. 10,555,513

METHOD AND APPARATUS FOR MEASURING TROLL DEPTHS

1. An instrument for measuring troll depths of a line drawn through water and having a proximal line end out of the water and a weighted, distal line end in the water, the instrument accounting for a curve of the line in the water, the instrument comprising:a reference to align with the line near the proximal line end;
a length designation identifying a length of the line extending in the water between the proximal line end and the distal line end; and
a depth scale having depth markings marking the troll depths at angles relative to the reference, wherein the depth markings exhibit nonlinear angular spacings relative to the reference, the depth markings marking the troll depths of the weighted, distal line end of the line accounting for the curve of the line in the water.

US Pat. No. 10,555,512

SPINNING REEL

Shimano Inc., Osaka (JP)...

1. A spinning reel, comprising:a reel body;
a handle disposed on the reel body so as to be rotatable;
a spool shaft supported by the reel body;
a spool configured to move in an axial direction of the spool shaft together with the spool shaft;
a rotor configured to rotate about the spool by rotation of the handle and wind a fishing line around the spool;
a reciprocating mechanism configured to move the spool shaft back and forth in the axial direction when the rotation of the handle is transmitted thereto; and
a clutch mechanism configured to be switched between a transmitting state to transmit the rotation of the handle to the reciprocating mechanism and a non-transmitting state to terminate the transmission,
the reciprocating mechanism enabling the spool shaft to move in the axial direction when the clutch mechanism is in the non-transmitting state.

US Pat. No. 10,555,511

STEERABLE FISHING LURE

1. A method of redirecting a track of a fishing lure on a fishing line, the fishing lure having a body, a fishing lure longitudinal axis extending along a length of the body, a line tie extending outwardly from the body, and a re-positioning mechanism connected to the line tie, the re-positioning mechanism being activated by the fishing line,the method comprising the steps of:
(a) using a fishing pole, casting the fishing lure into a body of water;
(b) while the fishing lure is in the water, reeling in the fishing lure; and
(c) moving the line tie between a first position and a second position such that, exteriorly of the body, the only movement is of the line tie, wherein the movement of the line tie between the first position and the second position changes a direction of travel of the fishing lure during step (b); wherein the re-positioning mechanism comprises a rotor assembly located in the fishing lure, the rotor assembly being operatively coupled to the line tie, and wherein step (b) comprises rotating the rotor assembly inside the fishing lure.

US Pat. No. 10,555,505

BEEHIVE STATUS SENSOR AND METHOD FOR TRACKING PESTICIDE USE IN AGRICULTURE PRODUCTION

1. A method of monitoring the health of an insect environment and its natural ecosystem surrounding comprising:monitoring the insect environment for the presence of at least one chemical using at least one sensor located within the insect environment, the at least one sensor operative to generate data in response to the presence of at least one chemical in the environment and communicate the data to an associated data processing device;
monitoring a population of insects in the insect environment to detect a change in the population or health of individual insects that make up the population; and
generating a correlation between a detected change in the population of insects or health of the insects that make up the population in the insect environment with an increase or decrease of the at least one chemical;
monitoring one or more environments external to the insect environment with which the insect population interacts for the at least one chemical; and
taking remedial action to increase or decrease the at least one chemical in the insect environment based at least in part on the correlation between a detected change in the population or health of insects in the insect environment with an increase or decrease of the at least one chemical;
wherein the remedial action includes increasing or decreasing a concentration of the at least one chemical in the one or more environments external to the insect environment.

US Pat. No. 10,555,502

STUFFED TOY CONTAINING CAT ATTRACTANT MATERIAL

THE HARTZ MOUNTAIN CORPOR...

1. A stuffed toy, comprising:a body and a head connected to the body, the body and the head together defining an internal space and forming an exterior of the stuffed toy; and
a container at least partially filled with a cat attractant material which emits an aroma, wherein the container is irremovably disposed within the internal space of the stuffed toy,
wherein the container includes a first opening located in a portion of the internal space corresponding to the head, in a portion of the internal space corresponding to a boundary between the body and the head, or in a portion of the internal space corresponding to the body but at a vicinity of the head,
wherein the first opening of the container is configured to remain open within the internal space of the stuffed toy, and the exterior of the stuffed toy is at least partially permeable to air such that the aroma emitted from the cat attractant material is greater at the head of the stuffed toy as compared to along the body.

US Pat. No. 10,555,501

COLLAR FOR MOUNTING AROUND THE NECK OF AN ANIMAL

16. A collar for mounting around a neck of an animal, said collar including:a first part with an inside for receiving the head of said animal, said first part having a flared shape and including a peripheral flexible wall defining said flared shape, said wall extending between a first opening leading into said inside and an opposite second opening leading into said inside,
a second part joined to said first part at said second opening, said second part defining a sleeve for extending around said neck, wherein said peripheral flexible wall includes a recess extending towards said first opening and defining an enlargement of said second opening, and
a patch joined to said flexible wall and covering said recess.

US Pat. No. 10,555,500

DRINKING BUCKET

1. A drinking bucket for feeding livestock a liquid food, the drinking bucket comprising:a holding area configured to hold the liquid food and further configured to couple to at least one teat;
an activity sensor configured to detect sucking activity on the at least one teat;
an electronic control connected to the activity sensor and configured to evaluate signals from the activity sensor to obtain activity information; and
at least one of a remote data transmission apparatus configured to transmit the activity information obtained from the electronic control and a display apparatus configured to display the activity information obtained from the electronic control, wherein the electronic control is connected to the at least one of a remote data transmission apparatus and the display apparatus.

US Pat. No. 10,555,499

VEHICLE-MOUNTABLE SPREADER

Wilson Customs, Evant, T...

7. An animal feed spreader for mounting to a tow hitch of a vehicle, the animal feed spreader comprising:an annular floor frame having an inner ring defining a first aperture, the annular floor frame having at least two fastening members;
a hopper comprising sidewalls coupled to the annular floor frame, at least a portion of the sidewalls defining a funnel-shaped portion of the hopper above the annular floor frame;
a floor plate removably coupled to the annular floor frame at the at least two fastening members, the floor plate having a second aperture with a circumference that is less than half of the circumference of the first aperture;
an arm having a first end portion affixed to the floor plate and a second end portion of the arm affixed to a clamp assembly;
a motor releasably coupled to the clamp assembly with a bottom face of the motor at least 2 cm above the circumference of the second aperture, the motor having a drive shaft traversing both the bottom face of the motor and the second aperture;
a spinning plate coupled to a distal end portion of the drive shaft opposite the bottom face of the motor, the spinning plate being at least 1 cm below the circumference of the second aperture, wherein the drive shaft and the spinning plate spin when the motor is in an active running state;
a pedestal assembly coupled to the annular floor frame, the pedestal assembly encasing the spinning plate with a plurality of columnar supports and a plurality of beam supports, the plurality of columnar supports coupling the plurality of beam supports to the annular floor frame, wherein the plurality of beam supports has a generally rectilinear toroidal shape with a base that is at least 4 cm below the spinning plate; and
a hitch assembly having a proximal end portion coupled to at least one of the pedestal assembly or the annular floor frame, the hitch assembly having a distal end portion operable to couple to the tow hitch of the vehicle.

US Pat. No. 10,555,498

METHOD AND SYSTEM FOR REMOTE MONITORING, CARE AND MAINTENANCE OF ANIMALS

Botsitter, LLC, Rowlett,...

1. A system for remote care of an animal comprising:a robotic animal caregiver including:
a housing;
a wireless data communication system disposed within the housing and wirelessly communicatively coupled with an external data communications system; and
a microprocessor in communication with the wireless data communication system disposed within the housing;
an aerial drone wirelessly communicatively coupled to the wireless data communication system of the robotic animal caregiver, the aerial drone comprising a microprocessor, a wireless communication module, a video camera, the aerial drone configured to act in response to instructions issued by the microprocessor of the robotic animal caregiver; and
wherein at least one of the robotic animal caregiver and the aerial drone comprises a dispenser configured to dispense at least one of food, water, and medication according to a pre-programmed schedule.

US Pat. No. 10,555,464

SELF-REGULATING, PLANT WATERING, INSERT ASSEMBLY FOR GROWING CONTAINERS

1. A self-regulating, wicking insert assembly for plant growing use in association with a reservoir-providing waterproof container having side wall structure between an open top end and a closed bottom end, water or water-nutrient, and grow media, said insert assembly comprising:a) a substantially planar and horizontally extending platform with a perimeter edge and a thickness dimension;
b) at least one vertically extending cylinder permanently fixed to and downwardly depending from said platform and positioned at least in part below said platform, said at least one cylinder also having an open top end, an open bottom end, a cylinder wall between said top end and said bottom end with an interior surface and an exterior surface, said cylinder wall also having small mesh openings therethrough;
c) at least some of said small mesh openings associated with said cylinder wall-positioned adjacent to said bottom end of said cylinder; and
d) gasket material outwardly depending from said perimeter edge of said platform and extending completely around said perimeter edge, said gasket material having a thickness dimension greater than said thickness dimension of said platform and extending above, below, and outwardly beyond said perimeter edge of said platform, wherein when said platform is placed into the reservoir-providing waterproof container having side wall structure between an open top end and a closed bottom end, and the reservoir-providing waterproof container has a cross-sectional configuration similar in size and shape to that of said perimeter edge of said platform, said bottom end of said at least one cylinder engages the closed bottom end of the reservoir-providing waterproof container while said gasket material engages the side wall structure of the reservoir-providing waterproof container, sealing any gaps between said perimeter edge and the side wall structure against downward movement of grow media therethrough, said at least one cylinder and said gasket material together securing said platform into a usable position within the reservoir-providing waterproof container, and when grow media is placed on and above said platform and also into said at least one cylinder, and when water or water-nutrient is placed into the reservoir-providing waterproof container below said platform, the water or water-nutrient passes through said small mesh openings and into said at least one cylinder, thereafter wicking upward into the grow media above said platform for plant growing use.

US Pat. No. 10,555,463

METHOD FOR MAINTAINING SOIL MOISTURE FOR A GARDEN VIA A SUMP PUMP

1. A method for maintaining soil moisture for a garden via a sump pump, said method comprising the steps of:installing an irrigation sump pump in a sump pit;
providing a water storage container;
connecting a first conduit to said irrigation sump pump and said water storage container, said first conduit promoting water transfer from said sump pit to said water storage container;
disposing at least one water distribution member at a predetermined area of a garden;
connecting a second conduit to said water storage container and said at least one water distribution member, said second conduit promoting water transfer from said water storage container to said at least one water distribution members;
controlling the water level in said sump pit;
controlling the high water level in said water storage container;
determining moisture level for at least one predetermined area of the garden; and
distributing water upon the at least one predetermined area of the garden when the moisture content is measured to be lower than a predetermined moisture parameter, whereby water in said sump pit is distributed upon the at least one predetermined area of the garden to increase soil moisture when a soil moisture parameter for the at least one predetermined area of the garden is determined to be below a predetermined low limit parameter.

US Pat. No. 10,555,462

AUTOMATED SPRINKLER ADJUSTMENT SYSTEM

Comcast Cable Communicati...

1. A method comprising:receiving, by a computing device, a water sensor measurement for a first sprinkler controller associated with a first geographic region;
determining, by the computing device, that the water sensor measurement satisfies a threshold;
determining a geographic association based on a geographic distance between the first geographic region and a second geographic region associated with a second sprinkler controller; and
based on the water sensor measurement satisfying the threshold and based on the geographic association, sending, by the computing device and to the second sprinkler controller, a message indicating an adjustment to a sprinkling schedule of the second sprinkler controller.

US Pat. No. 10,555,461

SYSTEMS AND METHODS FOR ESTIMATING EFFECTIVE PEST SEVERITY INDEX

Tata Consultancy Services...

1. A computer implemented method for estimating effective pest severity index, the method comprising:receiving a first set of inputs pertaining to weather associated with a geo-location under consideration;
receiving a second set of inputs pertaining to agronomic information associated with the geo-location under consideration;
generating a pest forecasting model and a natural enemies forecasting model for each pest associated with the geo-location under consideration, the pest forecasting model and the natural enemies forecasting model being based on the received first set of inputs and the second set of inputs, wherein the pest forecasting model is generated based on weather parameters derived from the first set of inputs, vegetation, soil and water indices derived from the second set of inputs, season of a year and a geographical region and wherein the natural enemies forecasting model is generated based on the pest forecasting model, the weather parameters derived from the first set of inputs, the vegetation, soil and water indices derived from the second set of inputs, the season of the year and the geographical region;
receiving participatory sensing information and crowdsourcing information associated with each pest and natural enemies in the geo-location under consideration for a period of time, wherein the participatory sensing information and crowdsourcing information comprise events from the geo-location under consideration during a life cycle of pests and natural enemies and images with geo-coordinates of pest affected areas;
dynamically updating the pest forecasting model and the natural enemies forecasting model based on the participatory sensing information and crowdsourcing information; wherein the pest forecasting model and the natural enemies forecasting model are dynamically updated based on a historical data lookup table of actual effective pest severity index detected for the corresponding first set of inputs and the second set of inputs for a given period of time; and
estimating the effective pest severity index based on the dynamically updated pest forecasting model and the natural enemies forecasting model, whereby a quantity and a timing of a pesticide application is recommended based on the estimated effective pest severity index, when the estimated effective pest severity index is greater than an Economic Threshold Level and the effective pest severity index is estimated as:
EP(n)=P(n)??NE(n),
wherein, EP(n) is Effective pest severity on nth day, P(n) is Pest severity forecasted for nth day, NE(n) is Population of Natural Enemies forecasted for nth day and a is scaling factor dependent on the season and a stage of pest as well as natural enemy.

US Pat. No. 10,555,459

ADJUSTABLE SHIELD FOR A STRING TRIMMER

1. A string trimmer comprising:a line trimmer and a supplemental guard;
wherein the supplemental guard attaches to the line trimmer;
wherein the line trimmer further comprises a cutting line, a rotating head, a primary guard disk, and an extension shaft;
wherein the supplemental guard adjusts the arc of the working range of the cutting line of the line trimmer;
wherein the primary guard disk further comprises a primary open inferior face, a primary closed superior face, and a primary lateral face;
wherein the primary lateral face further comprises an open primary vertical face and a closed primary vertical face;
wherein the supplemental guard is a mechanical structure;
wherein the supplemental guard is an adjustable structure;
wherein the supplemental guard rotates relative to the line trimmer such that the supplemental guard will modify the arc of the working range of the cutting line of the line trimmer;
wherein the supplemental guard comprises a supplemental guard disk, a telescopic shaft, a plurality of universal joints, and a pipe clamp;
wherein one of the plurality of universal joints attaches the telescopic shaft to the supplemental guard disk;
wherein another of the plurality of universal joints attaches the telescopic shaft to the pipe clamp.

US Pat. No. 10,555,456

AUTO MOWING SYSTEM

Positec Power Tools (Suzh...

1. A robotic mowing system comprising a station and a robotic mower, wherein the robotic mower has a controller, a memorizer, a power source and a drive motor, the memorizer configured to store a fixed working procedure and the controller configured to execute the fixed working procedure after receiving a start command input by a user so as to control the robotic mower to automatically and repeatedly mow and return to the station to be charged until the controller receives a stop command input by the user without a working parameter input by the user to define completion of mowing.

US Pat. No. 10,555,454

PLANTER ROW UNIT FURROW DEPTH SENSING APPARATUS AND METHOD

1. A row unit for a seeding machine, the row unit comprising:a frame;
a first gauge wheel arm pivotally coupled to the frame;
a first gauge wheel coupled to the first gauge wheel arm;
a second gauge wheel arm pivotally coupled to the frame;
a second gauge wheel coupled to the second gauge wheel arm; and
a depth sensor having a potentiometer coupled to the first gauge wheel arm.

US Pat. No. 10,555,452

ROW CLEANER/CLOSING WHEEL

10. A row cleaning wheel for mounting to a row cleaning assembly for use in operation of a row planter and adapted to remove debris, the row cleaning wheel comprising:a substantially circular body portion;
a circular center hub opening disposed at the center of the circular body portion for positioning the row cleaning wheel on a hub of a row cleaning mount assembly;
a set of holes for receiving fastening members for mounting the row cleaning wheel to a row cleaning wheel mount assembly; and
a first set of teeth arranged about the outer circumference of the circular body portion;
wherein each of the first set of teeth include a tooth body extending outward along the periphery of the first row cleaning wheel and having an essentially flat surface and a beveled surface that are relatively narrower at a distal end of the tooth and wider proximally toward the center of the row cleaning wheel, each tooth having a profile characterized by essentially parallel lines substantially along the length of the tooth body, wherein during operation of a row planter the parallel lines are essentially parallel with a ground surface when rotating and exiting the ground surface so as to deter debris and soil material from collecting on the surface of the tooth.
US Pat. No. 10,555,904

POUCH-LIKE STRUCTURE WITH PARACRINE ACTIVITY AND METHOD FOR ITS PREPARATION

Georg-August-Universitaet...

1. A method for the preparation of a pouch-like structure suitable for enclosing at least a part of the heart of a mammal and comprising engineered tissue, said engineered tissue comprising genetically engineered cells wherein said cells contain a gene encoding a paracrine factor and said gene being under control of an inducible promoter system or a heterologous promoter system, comprising the steps ofa) providing a matrix having a recess in one surface of the matrix, said recess has appropriate dimensions to hold a defined reconstitution volume for the formation of the pouch-like structure,
b) providing a body having dimensions corresponding to the desired dimensions of the interior of the pouch-like structure to be formed, and positioning the body in said recess of the matrix such that the body is spaced from the walls of said recess to form a space between the body and the walls of the recess corresponding to the reconstitution volume needed for formation of said pouch-like structure,
c) positioning a reconstitution mixture in the recess, said reconstitution mixture comprising mammalian cells, and suitable scaffold material which can be incubated to form an engineered tissue structure comprising said cells,
d) incubating said reconstitution mixture until the tissue construct forms within the matrix recess between the body and the matrix,
e) exchanging culture medium once the pouch-like construct has formed around the body,
f) removing the body with the tissue construct adherent thereto from the matrix recess, and
g) separating the tissue construct from the body,
wherein at least a part of said mammalian cells present in the engineered tissue structure are genetically engineered cells whereby said genetically engineered cells contain a gene encoding a paracrine factor and said gene being under control of an inducible promoter system or a heterologous promoter system.
US Pat. No. 10,556,930

HOST CELLS AND METHODS FOR PRODUCING FATTY ACID-DERIVATIVES WITH HIGH BRANCHED-CHAIN PERCENTAGE

Washington University, S...

1. A transformed host cell for producing a branched-chain acyl-acyl carrier protein (acyl-ACP) comprising: a nucleic acid encoding a branched-chain ?-keto acid dehydrogenase; a nucleic acid encoding a branched-chain-specific ?-ketoacyl-[acyl-carrier-protein] synthase III; and a nucleic acid encoding a lipoyl ligase A; wherein at least one of the nucleic acids is operably linked to a nucleic acid encoding an iron sulfur cluster chaperone.
US Pat. No. 10,555,906

ORAL SOLID CANNABINOID FORMULATIONS, METHODS FOR PRODUCING AND USING THEREOF

GELPELL AG, Gahwil (CH) ...

1. A gelatin matrix pellet comprising a pre-defined amount of an active ingredient in hemp oil or linseed oil,wherein said active ingredient is homogenously distributed in the absence of a water-miscible solvent,
wherein said active ingredient comprises at least one synthetic, semi-synthetic or natural cannabinoid, an extract of a cannabis plant, a combination of cannabis plant constituents, or a combination thereof, said at least one cannabinoid is selected from the group consisting of Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), Cannabichromene (CBC), Cannabicyclol (CBL), Cannabivarin, (CBV), Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV), Cannabichromevarin (CBCV), Cannabigerovarin (CBGV), Cannabigerol Monomethyl Ether (CBGM), and a combination thereof, and
wherein said gelatin matrix pellet is gastro-resistant and has a preferential intestinal dissolution.
US Pat. No. 10,556,932

COMPOSITIONS AND METHODS FOR SUPPRESSION OF INHIBITOR FORMATION AGAINST COAGULATION FACTORS IN HEMOPHILIA PATIENTS

The Trustees of the Unive...

1. An isolated recombinantly produced nucleic acid encoding Factor VIII having the sequence of SEQ ID NO: 15 or a sequence having 90% identity therewith.
US Pat. No. 10,555,909

MICROENCAPSULATION OF B-ALANINE

INNOBIO CORPORATION LIMIT...

1. A microencapsulated ?-alanine using ?-alanine as a core material and a mixture of a wall material and an additive as a release material, wherein:the additive comprises a fatty acid-based saturated or unsaturated fatty glyceride containing 12 to 22 carbon atoms and a phospholipid,
the fatty glyceride is a monoglyceride, a diglyceride, or a mixture thereof in any ratio,
a dosage of the fatty glyceride is 0.2 to 5% of a mass of the wall material; and
a dosage of the phospholipid is 0.5 to 10% of a mass of the wall material.
US Pat. No. 10,556,935

COMPOSITIONS FOR IMPROVING CELLS AND ORGANISMS

PRIMORDIAL GENETICS INC.,...

1. A nucleic acid molecule comprising:(a) the nucleotide sequence SEQ ID NO: 47;
(b) the nucleotide sequence that is complementary to the nucleotide sequence of SEQ ID NO: 47; or
(c) a nucleotide sequence encoding an amino acid sequence that is at least 90% identical to SEQ ID NO: 110.
US Pat. No. 10,555,910

OLIGONUCLEOTIDE LIPID NANOPARTICLE COMPOSITIONS, METHODS OF MAKING AND METHODS OF USING THE SAME

Ohio State Innovation Fou...

1. A method of inhibiting miRNA activity in vitro in a cell from a subject or in vivo to a cell in a subject, comprising:introducing an inhibitor composition to a location in vitro or in vivo where miRNA activity exists,
wherein the composition comprises at least one oligonucleotide encapsulated in a lipid nanoparticle;
the lipid nanoparticle being comprised of a combination of permanently ionized quaternary amine-cationic lipids and conditionally ionized tertiary amine-cationic lipids; the lipid nanoparticle having a formulation comprising at least:
quaternary amine 1,2-dioleoyl-3-dimethylammonium-propane (DOTAP);
tertiary amine 1,2-dioeyloxy-N,N-dimethyl-3-aminopropane (DODMA);
neutral lipid 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC);
helper lipid cholesterol (CHOL); and,
PEGylating agent N-(carbonyl-methoxypolyethyleneglycol 2000)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE-PEG),
wherein DOTAP and DODMA each constitute 40 mol percent of the total amount of lipids in the composition, or
wherein the lipids in the composition consist of DOTAP, DODMA, DOPC, CHOL, and PEG-DPPE present in respective molar ratios of 15:25:36:20:4; and,
inhibiting miRNA activity in vitro or in vivo.
US Pat. No. 10,555,911

HIGHLY PENETRATIVE NANOCARRIERS FOR TREATMENT OF CNS DISEASE

Yale University, New Hav...

1. A formulation comprising nanoparticles consisting of a core and shell which can be suspended in a pharmaceutically acceptable carrier for convection enhanced delivery (CED),wherein the core of the nanoparticles consist of biodegradable hydrophobic polymer selected from the group consisting of poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid)-polyethyleneglycol (PLA-PEG) block copolymers, polyanhydrides, poly(ester anhydrides), polyglycolide (PGA), poly-3-hydroxybutyrate (PHB) and copolymers thereof, poly-4-hydroxybutyrate (P4HB), blends thereof and copolymers thereof, and a therapeutic, diagnostic, or prophylactic agent, and
have an average diameter of between 25 and 100 nm, and
wherein the shell is on the surface of the nanoparticle core and the shell comprises a pharmaceutically acceptable sugar selected from the group consisting of trehalose, glucose, sucrose and lactose in an amount of between 10 and 50% by mass of the nanoparticle, effective to increase penetration of the nanoparticles through brain tissue.
US Pat. No. 10,556,937

METHODS FOR THE PRODUCTION OF A COSMETIC COMPOSITION COMPRISING LEUKOLECTIN AND USES THEREOF

AQUA BIO TECHNOLOGY ASA, ...

1. A method for improving the cosmetic appearance of a scar in the skin of a mammalian animal, said method comprising administering topically to said scar an effective amount of a cosmetic composition comprising(i) a polypeptide comprising:
(a) an amino acid sequence as set forth in any one of SEQ ID NOS: 1-4 or a sequence which is at least 90% identical to said sequence; or
(b) a portion of any of said sequences comprising at least 100 contiguous amino acids of said sequence; and
(ii) one or more pharmaceutically acceptable excipients and/or diluents, thereby improving the cosmetic appearance of a scar in the skin of a mammalian animal.
US Pat. No. 10,556,938

COMPOSITIONS AND METHODS OF USE FOR RECOMBINANT HUMAN SECRETOGLOBINS

APC Research Assets, LLC,...

1. A method of preventing hospitalization due to a severe respiratory exacerbation in a patient with acute lung injury comprising the steps of:(a) administering recombinant human SCGB3A2 (rhSCGB3A2) protein, wherein the rhSCGB3A2 protein consists of the amino acid sequence set forth in SEQ ID NO: 3, to a patient having an acute lung injury,
wherein the patient is not re-hospitalized for at least ten months after administration of rhSCGB3A2.
US Pat. No. 10,555,913

CLADRIBINE REGIMEN FOR TREATING MULTIPLE SCLEROSIS

MERCK SERONO SA, Coinsin...

1. A method of treating patients suffering from multiple sclerosis and who are refractory to at least one conventional therapy for multiple sclerosis comprising administering IFN-? in combination with cladribine, wherein cladribine is orally administered following the sequential steps below:(i) An induction period wherein cladribine is administered and wherein the total dose of cladribine reached at the end of the induction period is from about 1.7 mg/kg to about 3.5 mg/kg;
(ii) A cladribine-free period wherein no cladribine is administered;
(iii) A maintenance period wherein cladribine is administered and wherein the total dose of cladribine administered during the maintenance period is lower than or equal to the total dose of cladribine reached at the end of the induction period (i); and
(iv) A cladribine-free period wherein no cladribine is administered.
US Pat. No. 10,555,914

METHODS OF PRODUCING ANIONIC CANNABINOID MOLECULES DISSOLVED IN WATER

Natural Extraction System...

1. A method to solubilize a cannabinoid in water, comprising:providing a cannabinoid molecule, the cannabinoid molecule is cannabidiol and comprises an aromatic ring and a hydroxyl group, and the hydroxyl group is a substituent on the aromatic ring;
providing a Brønsted base and ethanol;
providing water;contacting the cannabinoid molecule with the Brønsted base and the ethanol to deprotonate the hydroxyl group and to produce an anionic cannabinoid molecule; anddissolving the anionic cannabinoid molecule in the water to produce a solution comprising the anionic cannabinoid molecule;
the solution comprising the anionic cannabinoid molecule has a pH of at least 8.5; and the anionic cannabinoid molecule is selected from the group consisting of:2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate; 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-pentylphenolate; 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentyl-1,4-benzoquinone-3-oxide;3-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-6-pentyl-1,2-benzoquinone-4-oxide;2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-5-pentyl-1,4-benzoquinone-3-oxide;3-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-6-pentyl-1,2-benzoquinone-4-oxide; and(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-oxide.
US Pat. No. 10,556,940

T CELL RECEPTORS RECOGNIZING HLA-CW8 RESTRICTED MUTATED KRAS

The United States of Amer...

1. An isolated or purified TCR comprising:(I) an ? chain complementarity determining region (CDR) 1 comprising the amino acid sequence of SEQ ID NO: 3, an ? chain CDR2 comprising the amino acid sequence of SEQ ID NO: 4, and an ? chain CDR3 comprising the amino acid sequence of SEQ ID NO: 5; and
(II) a ? chain CDR1 comprising the amino acid sequence of SEQ ID NO: 6, a ? chain CDR2 comprising the amino acid sequence of SEQ ID NO: 7, and a ? chain CDR3 comprising the amino acid sequence of SEQ ID NO: 8.
US Pat. No. 10,555,915

METHODS FOR TREATING ACUTE ACOUSTIC TRAUMA

Hough Ear Institute, Okl...

1. A method for treating sensorineural hearing loss, comprising orally delivering to a patient in need thereof a composition comprising a pharmaceutically effective amount of 2,4-disulfonyl ?-phenyl tertiary butyl nitrone.
US Pat. No. 10,556,941

POLYPEPTIDES AND USES THEREOF FOR REDUCING CD95-MEDIATED CELL MOTILITY

1. A nucleic acid sequence encoding for a fusion protein comprising a polypeptide having an amino acid sequence having at least 96, 97, 98, 99, or 100% identity with an amino acid sequence ranging from an amino acid residue at position 175 to an amino acid residue at position 209 or 210 as set forth in SEQ ID NO: 1, wherein said polypeptide is fused to a heterologous cell-penetrating polypeptide.
US Pat. No. 10,556,942

PROCESS FOR THE PURIFICATION OF TNFR:FC FUSION PROTEIN

LUPIN LIMITED, Mumbai (I...

1. A process for purifying the TNFR:Fc fusion protein from the protein mixture comprising TNFR:Fc fusion protein and at least one HCP impurity containing protein degrading enzyme, the said process comprising:a) obtaining protein mixture from the suitable mammalian expression system comprising TNFR:Fc fusion protein and host cell protein (HCP) impurities containing at least one protein degrading enzyme;
b) applying the protein mixture to Protein A affinity chromatography column;
c) eluting the TNFR:Fc fusion protein from Protein A affinity chromatography column wherein the eluted TNFR:Fc fusion protein is present in second protein mixture containing reduced amount of HCP impurity;
d) applying the second protein mixture to Hydrophobic interaction chromatography column;
e) eluting the TNFR:Fc fusion protein from a Hydrophobic interaction chromatography column wherein the eluted TNFR:Fc fusion protein is present in third protein mixture contains reduced amount of HCP impurity;
f) applying the third protein mixture to anion exchange chromatography column;
g) eluting the TNFR:Fc fusion protein from a anion exchange chromatography column wherein the eluted protein of interest is present in fourth protein mixture containing reduced amount of HCP impurity;
h) applying the fourth protein mixture to mixed-mode chromatography column;
i) eluting the TNFR:Fc fusion protein from a mixed-mode chromatography column wherein the eluted TNFR:Fc fusion protein is substantially free of HCP impurity containing at least one of the protein degrading enzyme.
US Pat. No. 10,555,917

METHODS OF TREATING A NEUROLOGICAL OR PSYCHIATRIC DISORDER

BNIW Ventures LLC., Chic...

1. A method of treating a neurological or psychiatric disorder in a subject in need thereof, comprising: administering to the subject a therapeutically effective amount of ketamine or a pharmaceutically acceptable salt thereof in combination with an amount of one or more compounds effective to increase the level of nicotinamide adenine dinucleotide (NAD+) in the subject.
US Pat. No. 10,556,943

HLA-DR BINDING PEPTIDES AND THEIR USES

Mayo Foundation for Medic...

1. A method for eliciting an immunogenic response in a mammal, wherein the method comprises administering to the mammal a composition comprising a pharmaceutical excipient and isolated immunogenic HLA-DR binding peptides having the sequences set forth in SEQ ID NOS:86, 90, 109, and 145 such that an immunogenic response occurs in the mammal.
US Pat. No. 10,556,944

FAB REGION-BINDING PEPTIDE

KANEKA CORPORATION, Osak...

1. A Fab region-binding peptide represented by any one of the following (1) to (3):(1) a Fab region-binding peptide having an amino acid sequence of SEQ ID NO: 1 derived from the ?1 domain of protein G with substitution of an amino acid residue at not less than one position selected from the 13th, 19th, 30th and 33rd positions, and having a higher binding force to the Fab region of immunoglobulin than that before introduction of the substitution,
wherein the amino acid residue at the 13th position is substituted by Thr or Ser,
the amino acid residue at the 30th position is substituted by Val, Leu or Ile,
the amino acid residue at the 19th position is substituted by Val, Leu or Ile,
the amino acid residue at the 33rd position is substituted by Phe;
(2) a Fab region-binding peptide having an amino acid sequence specified in the (1) with deletion, substitution and/or addition of not less than 1 and not more than 7 amino acid residues at a region other than the 13th, 19th, 30th and 33rd positions, and having a higher binding force to the Fab region of immunoglobulin than the peptide having the amino acid sequence of SEQ ID NO: 1;
wherein the position of deletion, substitution and/or addition of an amino acid residue is at least one position selected from the group consisting of the 2nd, 10th, 15th, 18th, 21st, 22nd, 23rd, 24th, 25th, 27th, 28th, 31st, 32nd, 35th, 36th, 39th, 40th, 42nd, 45th, 47th, 48th and 50th positions;
the amino acid residue at the 2nd position is substituted by Arg,
the amino acid residue at the 10th position is substituted by Arg,
the amino acid residue at the 15th position is substituted by Gln or Thr,
the amino acid residue at the 18th position is substituted by Ala,
the amino acid residue at the 21st position is substituted by Ile, Ala or Asp
the amino acid residue at the 22nd position is substituted by Asn or Glu,
the amino acid residue at the 23rd position is substituted by Thr or Asp,
the amino acid residue at the 24th position is substituted by Thr,
the amino acid residue at the 25th position is substituted by Ser or Met,
the amino acid residue at the 27th position is substituted by Asp or Gly,
the amino acid residue at the 28th position is substituted by Arg, Asn or Ile,
the amino acid residue at the 31st position is substituted by Arg,
the amino acid residue at the 32nd position is substituted by Arg,
the amino acid residue at the 35th position is substituted by Phe or Tyr,
the amino acid residue at the 36th position is substituted by Gly,
the amino acid residue at the 39th position is substituted by Leu or Ile,
the amino acid residue at the 40th position is substituted by Val or Glu,
the amino acid residue at the 42nd position is substituted by Leu, Val or Gln,
the amino acid residue at the 45th position is substituted by Phe,
the amino acid residue at the 47th position is substituted by His, Asn, Ala, Gly or Tyr,
the amino acid residue at the 48th position is substituted by Thr, and
the amino acid residue at the 50th position is substituted by Arg or Glu,
(3) a Fab region-binding peptide having an amino acid sequence having not less than 85% sequence identity to the amino acid sequence specified in the (1), and having a higher binding force to the Fab region of immunoglobulin than the peptide having the amino acid sequence of SEQ ID NO: 1, wherein the substituted amino acid residue at not less than 1 position selected from the 13th, 19th, 30th, and 33rd positions of the amino acid sequence specified in the (1) is not further mutated in the (3).
US Pat. No. 10,556,945

ANTAGONIST ANTIBODIES DIRECTED AGAINST CALCITONIN GENE-RELATED PEPTIDE AND METHODS USING SAME

Teva Pharmaceuticals Inte...

1. A method of treating or reducing incidence of headache in a subject, the method comprising:administering to the subject an amount of a monoclonal antibody that inhibits the calcitonin gene-related peptide (CGRP) pathway,
wherein the monoclonal antibody comprises a CDR H1 as set forth in SEQ ID NO:3; a CDR H2 as set forth in SEQ ID NO:4; a CDR H3 as set forth in SEQ ID NO:5; a CDR L1 as set forth in SEQ ID NO:6; a CDR L2 as set forth in SEQ ID NO:7; and a CDR L3 as set forth in SEQ ID NO:8,
wherein the monoclonal antibody is administered at a dose of about 225 mg at one month intervals, and
wherein the monoclonal antibody is formulated at a concentration of at least 150 mg/mL, thereby treating or reducing incidence of headache in the subject.
US Pat. No. 10,556,946

HUMAN DERIVED ANTI-HUNTINGTIN (HTT) ANTIBODIES AND USES THEREOF

Neurimmunie Holding AG, ...

1. A human-derived monoclonal anti-huntingtin (HTT) antibody, or an HTT-binding fragment, synthetic derivative, or biotechnological derivative thereof, wherein the antibody, or fragment or derivative thereof, comprises:(a) (i) in its variable heavy (VH) chain and variable light (VL) chain the following six complementarity determining regions (CDRs):
(1) VH-CDR1: positions 31-35 of SEQ ID NO: 173, or a variant thereof, wherein the variant comprises one or two amino acid substitutions,
(2) VH-CDR2: positions 50-66 of SEQ ID NO: 173, or a variant thereof, wherein the variant comprises one or two amino acid substitutions,
(3) VH-CDR3: positions 99-108 of SEQ ID NO: 173, or a variant thereof, wherein the variant comprises one or two amino acid substitutions,
(4) VL-CDR1: positions 23-36 of SEQ ID NO: 175, or a variant thereof, wherein the variant comprises one or two amino acid substitutions,
(5) VL-CDR2: positions 52-58 of SEQ ID NO: 175, or a variant thereof, wherein the variant comprises one or two amino acid substitutions,
(6) VL-CDR2: positions 91-101 of SEQ ID NO: 175, or a variant thereof, wherein the variant comprises one or two amino acid substitutions; or
(ii) an amino acid sequence of the VH region set forth in SEQ ID NO: 173, or an amino acid sequence that is at least 90% identical to SEQ ID NO: 173; and an amino acid sequence of the VL region set forth in SEQ ID NO: 175, or an amino acid sequence that is at least 90% identical to SEQ ID NO: 175; and
(b) wherein the antibody, fragment or derivative thereof is
(i) a fusion protein comprising a polypeptide sequence which is heterologous to the VH region or VL region, or at least one CDR; or
(ii) a non-natural variant of a polypeptide derived from an immunoglobulin, said non-natural variant comprising a heavy chain constant region that comprises one or more amino acid deletions, substitutions, or additions relative to a wild type polypeptide.
US Pat. No. 10,556,947

BINDING MOLECULE THAT BINDS SPECIFICALLY TO THE PRECURSOR OF BRAIN-DERIVED NEUROTROPHIC FACTOR

Shanghai Yile Biotechnolo...

1. A method for mitigating or treating rheumatoid arthritis comprising administering to a subject in need thereof a binding molecule which specifically binds to a precursor of brain-derived neurotrophic factor, wherein the binding molecule is a monoclonal antibody comprising a heavy chain variable region having a CDR1 region with at least 95% sequence homology to SEQ ID NO: 1, a CDR2 region with at least 95% sequence homology to SEQ ID NO: 2 and a CDR3 region with at least 95% sequence homology to SEQ ID NO: 3; and a light chain variable region having a CDR1 region with at least 95% sequence homology to SEQ ID NO: 4, a CDR2 region with at least 95% sequence homology to SEQ ID NO: 5 and a CDR3 region with at least 95% sequence homology to SEQ ID NO: 6.
US Pat. No. 10,556,949

ANTIGEN-BINDING MOLECULE INDUCING IMMUNE RESPONSE TO TARGET ANTIGEN

Chugai Seiyaku Kabushiki ...

1. A method of inducing humoral immunity to a target antigen, the method comprising identifying a subject as being in need of induction of humoral immunity to the target antigen, and administering to the subject a pharmaceutical composition comprising an antibody as an active ingredient, wherein the antibody comprises an antigen-binding domain identified by (a) and an FcRn-binding domain identified by (b):(a) identification of an antigen-binding domain that comprises a complementary determining region (CDR) comprising at least one histidine residue, and has higher antigen-binding activity to the target antigen at pH 7.4 than its antigen-binding activity to the target antigen at pH 5.8;
(b) identification of an FcRn-binding domain that binds to a human FcRn at pH 7.4 and has a higher binding affinity to the human FcRn at pH 7.4 than the binding affinity of a native human IgG1 Fc region to the human FcRn at pH 7.4;
wherein, when administered to the subject, the antibody induces humoral immunity to the target antigen in the subject.
US Pat. No. 10,555,925

METHODS OF REDUCING THE RISK OF A CARDIOVASCULAR EVENT IN A SUBJECT AT RISK FOR CARDIOVASCULAR DISEASE

Amarin Pharmaceuticals Ir...

1. A method of reducing risk of stroke in a subject with established cardiovascular disease, the method comprising administering to said subject about 4 g of ethyl icosapentate per day for a period effective to reduce risk of stroke in the subject.
US Pat. No. 10,556,951

ANTI-CD33 ANTIBODIES AND IMMUNOCONJUGATES

Genentech, Inc., South S...

1. An isolated antibody that binds to CD33, wherein the antibody comprises:(i) (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:39; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:40; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:41; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:36; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:37; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:38;
(ii) (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:45; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:46; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:47; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:42; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:43; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:44;
(iii) (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:45; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:51; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:52; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:48; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:49; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:50;
(iv) (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:56; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:57; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:58; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:53; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:54; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:55; or
(v) (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:62; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:63; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:64; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:59; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:60; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:61.
US Pat. No. 10,555,926

USE OF CABAZITAXEL IN THE TREATMENT OF PROSTATE CANCER

Erasmus University Medica...

1. A method of treating a patient suffering from prostate cancer comprising determining the androgen receptor mRNA splice variant 7 (AR-V7)-status in said patient and administering a therapeutically effective amount of cabazitaxel in base form or in the form of an hydrate or a solvate, to an AR-V7-positive patient, in combination with a corticoid.
US Pat. No. 10,556,952

HEAVY CHAIN CONSTANT REGIONS WITH REDUCED BINDING TO FC GAMMA RECEPTORS

Regeneron Pharmaceuticals...

1. An immunoglobulin heavy chain comprising a constant region, wherein amino acid positions 233-236 of a hinge domain are G, G, G and unoccupied; G, G, unoccupied, and unoccupied; G, unoccupied, unoccupied, and unoccupied; or all unoccupied, with amino acid positions numbered by EU numbering.
US Pat. No. 10,556,953

AGENT CAPABLE OF DEPLETING CD8 T CELLS FOR THE TREATMENT OF MYOCARDIAL INFARCTION OR ACUTE MYOCARDIAL INFARCTION

1. A method for treating myocardial infarction (MI) or acute myocardial infarction (AMI) in a subject in need thereof comprising the step of administering to said subject within 14 days of the infarction a therapeutically effective amount of an anti-CD8 antibody capable of depleting CD8 T cells.
US Pat. No. 10,555,928

CANNABIS EXTRACTS AND METHODS OF PREPARING AND USING SAME

United Cannabis Corp., G...

1. A method for relieving symptoms associated with anxiety, post traumatic stress disorder, chronic pain, or opiate dependency, paralysis, neuropathy, Crohns disease, inflammatory bowel disorders, glaucoma, seizures, epilepsy, autism, or cancer comprising administering to a subject at least four daily doses of a cannabinoid formulation, wherein at least two of the at least four daily doses comprise different cannabinoid formulations selected from the group of cannabinoid formulations consisting of:a. a formulation wherein at least 95% of the total cannabinoids in the formulation is tetrahydrocannabinolic acid (THCa);
b. a formulation wherein at least 95% of the total cannabinoids in the formulation is tetrahydrocannabinol (THC);
c. a formulation wherein at least 95% of the total cannabinoids in the formulation is cannabidiol (CBD);
d. a formulation wherein at least 95% of the total cannabinoids in the formulation are THCa and cannabidiolic acid (CBDa);
e. a formulation wherein at least 95% of the total cannabinoids in the formulation are THC and CBD;
f. a formulation wherein at least 95% of the total cannabinoids in the formulation are CBD, cannabinol (CBN) and THC;
g. a formulation wherein at least 95% of the total cannabinoids in the formulation is cannabidiol (CBDa);
h. a formulation wherein at least 95% of the total cannabinoids in the formulation is cannabichromene (CBC);
i. a formulation wherein at least 95% of the total cannabinoids in the formulation is cannabichromenic acid (CBCa);
j. a formulation comprising at least 95% tetrahydrocannabinol (THC) as the only cannabinoid in the formulation; and
k. a formulation wherein at least 95% of the total cannabinoids in the formulation is tetrahydrocannabinol (THC) from cannabis indica or cannabis ruderalis.
US Pat. No. 10,557,978

COMPOSITION, OPTICAL FILM INCLUDING COMPOSITION, AND METHOD OF PRODUCING OPTICAL FILM

SUMITOMO CHEMICAL COMPANY...

1. A composition comprising smectic liquid crystal compounds, each having a 1,4-cyclohexyl group,wherein the composition contains 0.1 parts by mass to 10 parts by mass of a smectic liquid crystal compound having a cis-1,4-cyclohexyl group relative to 100 parts by mass of a smectic liquid crystal compound having a trans-1,4-cyclohexyl group,
the smectic liquid crystal compound having the trans-1,4-cyclohexyl group and the smectic liquid crystal compound having the cis-1,4-cyclohexyl group are represented by the following formula (1-1) and formula (2-1), respectively:
P1-F1-B1-CyH-G1-E1-G2-E2-B2-F2-P2  (1-1)
P1-F1-B1-CyH?-G1-E1-G2-E2-B2-F2-P2  (2-1)
wherein in each of the formulas (1-1) and (2-1):
P1 and P2 each independently represent a polymerizable group, P1 in the formula (1-1) and P1 in the formula (2-1) are identical groups, and P2 in the formula (1-1) and P2 in the formula (2-1) are identical groups;
at least one of F1 and F2 represents a C6-C12 linear alkanediyl group, a hydrogen atom contained in the alkanediyl group can be substituted by a halogen atom, and —CH2— contained in the alkanediyl group can be substituted by —O—, F1 in the formula (1-1) and F1 in the formula (2-1) are identical groups, and F2 in the formula (1-1) and F2 in the formula (2-1) are identical groups;
B1 and B2 each independently represent a single bond or a bivalent linking group, B1 in the formula (1-1) and B1 in the formula (2-1) are identical groups, and B2 in the formula (1-1) and B2 in the formula (2-1) are identical groups;
CyH represents a substituted or unsubstituted trans-1,4-cyclohexyl group;
CyH' represents a substituted or unsubstituted cis-1,4-cyclohexyl group;
G1 and G2 each independently represent a single bond or a bivalent linking group, G1 in the formula (1-1) and G1 in the formula (2-1) are identical groups, and G2 in the formula (1-1) and G2 in the formula (2-1) are identical groups; and
E1 and E2 each independently represent a group selected from a substituted 1,4-phenyl group, an unsubstituted 1,4-phenyl group, a substituted trans-1,4-cyclohexyl group, and an unsubstituted trans-1,4-cyclohexyl group, E1 in the formula (1-1) and E1 in the formula (2-1) are identical groups, and E2 in the formula (1-1) and E2 in the formula (2-1) are identical groups.
US Pat. No. 10,556,955

METHOD FOR PURIFYING ACTIVE POLYPEPTIDES OR IMMUNOCONJUGATES

MedImmune Limited, Cambr...

1. A method of treating a B cell malignancy comprising intravenously administering to a subject in need of treatment for a B cell malignancy a composition comprising a purified protein comprising the VH-PE38 subunit of SEQ ID NO: 1 and the VL subunit of SEQ ID NO: 2, wherein the composition comprises less than 25% deamidated species of the protein, and wherein said administration is at a dose of 20-50 ?g/kg per day.
US Pat. No. 10,555,932

METHOD OF RESTORING ANALGESIC EFFICACY OF ALPHA2-ADRENOCEPTOR AGONISTS IN NEUROPATHIC PAIN TREATMENT

KOREA INSTITUTE OF SCIENC...

1. A method of relieving chronic neuropathic pain of a subject, the method comprising:administering 0.1 to 200 ?g/kg of an alpha 2 (?2)-adrenoceptor agonist to the subject in need thereof; and
administering an effective amount of an inhibitor selected from an inhibitor of a regulator of a G-protein signaling (RGS), an endocytosis inhibitor, or a combination thereof to the subject in need thereof,
wherein an effective amount of the inhibitor causes the administered alpha 2 (?2)-adrenoceptor agonist to relieve the chronic neuropathic pain,
wherein the subject is a mammal, and
wherein the endocytosis inhibitor is dynasore or chloroquine.
US Pat. No. 10,556,959

ANTI-CD39 ANTIBODIES AND USES THEREOF

Xencor, Inc., Monrovia, ...

1. An isolated antibody that binds to CD39, wherein the antibody comprises:(a) a heavy chain variable (VH) region comprising a VH CDR1 having SEQ ID NO:155, a VH CDR2 having SEQ ID NO:160, and a VH CDR3 having SEQ ID NO:165; and/or
(b) a light chain variable (VL) region comprising a VL CDR1 having SEQ ID NO:169, a VL CDR2 having SEQ ID NO:173, and a VL CDR3 having SEQ ID NO:175.
US Pat. No. 10,555,936

CHEMOTHERAPEUTIC COMPOSITIONS AND METHODS FOR TREATING HUMAN GLIOMAS

THE METHODIST HOSPITAL, ...

1. A compound, comprising a targeting/seeker moiety that is specific for a mammalian monoamine oxidase B (MAO-B) enzyme, operably linked via a linker moiety to a therapeutic moiety that comprises a DNA acylating agent or a DNA damaging agent, wherein the therapeutic moiety is a neutral, blood-brain barrier-permeable pro-drug selected from the group consisting of a nitrogen mustard, a sulfur mustard, a platin tetranitrate, vinblastine, docetaxel, etoposide, SN38, camptothecin, carmustine, and any combination thereof, and further wherein the targeting/seeker moiety has a specificity for a MAO-B enzyme that is at least two-fold greater than its specificity for a MAO-A enzyme.
US Pat. No. 10,556,962

ANTI-OX40 ANTIBODIES AND THEIR USES

AbbVie Biotherapeutics In...


US Pat. No. 10,555,937

PHARMACEUTICAL COMPOSITIONS

XSPRAY MICROPARTICLES AB,...

19. A pharmaceutical composition, consisting of:(a) particles consisting of
(i) a protein kinase inhibitor having a degree of amorphicity of 100% in an amount of from about 10% by weight to about 70% by weight of the particles; and
(ii) copolyvidone; and
(b) an excipient;
wherein the protein kinase inhibitor is dasatinib, dasatinib hydrate, dasatinib solvate, dasatinib salt, or combinations thereof.
US Pat. No. 10,556,963

MEANS AND METHODS FOR COUNTERACTING MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISORDERS

AIMM THERAPEUTICS B.V., ...

1. An antibody, or a functional part thereof,wherein said functional part thereof is defined as a single chain variable fragment (scFv), a Fab fragment or a F(ab?)2 fragment;
wherein said antibody or functional part is able to bind a cell surface component of acute myeloid leukemia (AML) cells, comprising:
a heavy chain CDR1 sequence comprising SEQ ID NO: 209;
a heavy chain CDR2 sequence comprising SEQ ID NO: 213;
a heavy chain CDR3 sequence comprising SEQ ID NO: 217;
a light chain CDR1 sequence comprising SEQ ID NO: 221;
a light chain CDR2 sequence comprising SEQ ID NO: 225; and
a light chain CDR3 sequence comprising SEQ ID NO: 229; and
wherein said antibody is, synthetic or recombinant; and
wherein said antibody or functional part is coupled to a detectable label, a chemotherapeutic drug, a toxic moiety, a CD3-specific binding compound, another AML-specific binding compound, or a radioactive compound.
US Pat. No. 10,555,940

PHOSPHODIESTERASE INHIBITOR TREATMENT

1. A method for treating hyposmia in a human comprising intranasally administering to the human a non-theophylline containing pharmaceutical composition comprising a therapeutically effective amount of a phosphodiesterase (PDE) inhibitor, wherein the PDE inhibitor is PDE-4 selective inhibitor that comprises roflumilast, and a pharmaceutically acceptable carrier, wherein the therapeutically effective amount comprises less than 1 mg of the PDE inhibitor.
US Pat. No. 10,556,966

ANTI-HER2 ANTIBODIES AND IMMUNOCONJUGATES

Genentech, Inc., South S...

1. An isolated nucleic acid encoding an antibody that binds to HER2, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:15; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:16; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:17; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:12; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:13; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:14.
US Pat. No. 10,556,968

BINDING MOLECULES SPECIFIC FOR CD73 AND USES THEREOF

MEDIMMUNE LIMITED, Cambr...

1. An isolated nucleic acid molecule encoding an antibody or antigen-binding fragment thereof that specifically binds to CD73, wherein the antibody or antigen-binding fragment thereof comprises a heavy chain VH domain and a light chain VL domain, the heavy and light chain VH and VL domains comprising: (a) a VH CDR1 having the amino acid sequence of SEQ ID NO: 36: (b) a VH CDR2 having the amino acid sequence of SEQ ID NO: 39: (c) a VH CDR3 having the amino acid sequence of SEQ ID NO: 45: (d) a VL CDR1 having the amino acid sequence of SEQ ID NO: 46; (e) a VL CDR2 having the amino acid sequence of SEQ ID NO: 51: and (f) a VL CDR3 having the amino acid sequence of SEQ ID NO: 56.
US Pat. No. 10,556,972

PROCESS FOR THE POLYMERIZATION OF OLEFINS

Basell Poliolefine Italia...

1. A gas-phase process for the homopolymerization or copolymerization of olefins comprising the following steps:1) contacting, in a liquid hydrocarbon and in the absence of olefins, (a) a solid catalyst component comprising Ti, Mg, and Cl, and optionally an internal electron donor compound (ID), (b) an aluminum alkyl compound and optionally (c) an external donor compound; and
2) feeding a product of the contacting step 1) to a gas-phase polymerization reactor under polymerization conditions, wherein the contacting step 1) is carried out in the presence of H2 in an amount ranging from 0.1 to 8 g per kg of solid catalyst component (a).
US Pat. No. 10,556,974

CURABLE AND HYGROSCOPIC RESIN COMPOSITION FOR SEALING ELECTRONIC DEVICES, SEALING RESIN, AND ELECTRONIC DEVICE

FURUKAWA ELECTRIC CO., LT...

1. A curable and hygroscopic resin composition for sealing electronic devices, comprisingfrom 5 to 30 mass % of at least a (meth)acrylate oligomer (a) having a number-average molecular weight of 1,500 to 5,000,
from 40 to 90 mass % of a low molecular weight (meth)acrylate (b) having an average molecular weight of 170 to 500,
from 5 to 30 mass % of a moisture-reactive organometallic compound (c), and
a polymerization initiator (d),
wherein the (meth)acrylate oligomer (a) and the low molecular weight (meth)acrylate (b) are multifunctional (meth)acrylates in which the number of (meth)acryloyl groups is from 1.5 to 3 in one molecule of each of the (meth)acrylate oligomer (a) and the low molecular weight (meth)acrylate (b); and
wherein the (meth)acrylate oligomer (a) is a resin whose main chain is a polybutadiene or a hydrogenated polybutadiene.
US Pat. No. 10,557,486

USE OF TREATING ELEMENTS TO FACILITATE FLOW IN VESSELS

CRYSTAPHASE PRODUCTS, INC...

1. A method of improving flow distribution of one or more streams in a process vessel comprising:passing the one or more streams through an upstream processing zone and a downstream processing zone within the process vessel, the upstream processing zone and downstream processing zone each containing one or more beds of processing materials; and
passing the one or more streams through a redistribution treating zone located between the upstream processing zone and downstream processing zone,
wherein the redistribution treating zone has a depth of four feet or less and contains treating elements,
and wherein the redistribution treating zone mitigates stream channeling of the streams exiting the upstream processing zone and affects lateral redistribution of the flow of the one or more streams within the downstream processing zone,
and wherein the treating elements have more than one opening passing therethrough,
and wherein the treating elements have asperities formed on the surfaces thereof, the asperities comprising one or more of flutes, fins and struts,
and wherein the treating elements have one or more open cells which form a plurality of interconnected fluid flow pathways within and through each treating element,
and wherein the treating elements are up to 100 times the size of the individual processing materials within the process vessel.
US Pat. No. 10,557,231

METHOD FOR COLORING CELLULOSE

1. A process for coloring cellulose in supercritical CO2 medium with a hydrophobic dye, comprising at least the steps:(i) providing cellulose fibers,
(ii) placing said cellulose fibers in contact with:
a) an effective amount of at least one uncharged primary monoorganourea selected from the group consisting of 4-methoxyphenylurea and octadecylurea, under conditions suitable for establishing a covalent bond of carbamate type between the cellulose and each molecule of said organourea; and
b) at least one hydrophobic dye, in supercritical CO2 medium, under conditions suitable for immobilizing said dye on said fibers.
US Pat. No. 10,555,956

CHEMOPREVENTION OF COLORECTAL CANCER

SOFAR SPA, Trezzano Rosa...

1. A combination, comprising:(i) a 5-aminosalicylic acid component, wherein the 5-aminosalicylic acid component comprises 5-aminosalicylic acid or a pharmacologically acceptable salt of 5-aminosalicylic acid; and
(ii) a group D vitamin component, wherein the group D vitamin component is selected from the group consisting of vitamin D3, vitamin D2, 25-hydroxy-vitamin D3 and 1-alpha,25 dihydroxy-vitamin D3;
wherein the combination includes between 0.5 grams and 5 grams of the 5-aminosalicylic acid component and between 500 international units and 10,000 international units of the group D vitamin component; and
wherein the combination does not include calcium.
US Pat. No. 10,556,982

THERMOPLASTIC POLYURETHANE RESIN COMPOSITION HAVING ENHANCED TEXTURE AND DURABILITY AND PRODUCTION METHOD THEREOF

Hyundai Motor Company, S...

1. A thermoplastic polyurethane resin composition comprising:isocyanate compound;
a polyester polyol; and
a chain extender,
wherein the polyester polyol is prepared from a mixture of reactants including polytetramethylene ether glycol and polydimethylsiloxane diol,
wherein the polyester polyol is prepared from a mixture of reactants including a multifunctional carboxylic acid compound, a multifunctional alcohol compound, polytetramethylene ether glycol and polydimethylsiloxane diol, and
wherein the multifunctional alcohol compound is one or more selected from a group consisting of one or more diols selected from a group consisting of ethylene glycol, butane diol, and hexane diol; and trimethylol propane.
US Pat. No. 10,556,984

CHEMICALLY DECOMPOSABLE EPOXIDE RESIN SYSTEM

11. A method of constructing reinforced plastic components for use in aeroplanes, in rail vehicle construction, in wind energy plants, and in the automotive industry, comprising the steps of:(a) forming a cured component of a curable epoxide resin system; and
(b) using such cured component and when finished using such cured component, recycling the epoxide resin system forming the cured component by chemically decomposing the cured component by aminolysis with reactive NH2— or other amino groups and/or alcoholysis with mono-, di-, or poly functional alcohols,
wherein the curable epoxide resin system forming the cured component comprises one or more epoxide resins and one or more curing agents; wherein the one or more curing agents comprise at least one cyanate with the formula R—O—C?N, wherein R is an organic residue which is aromatic, partially halogenated-aliphatic or perhalogenated-aliphatic; wherein the at least one cyanate is present in amount such that cyanate groups constitute at least 30% of reactive functional groups present in the curable epoxide resin system; and wherein the cured product comprises an epoxide resin polymer and cyanurates.
US Pat. No. 10,555,959

GLYCOLIPIDS AS TREATMENT FOR DISEASE

La Jolla Pharmaceutical C...

1. A method of treating a subject having a GM3 deficiency, comprising administering to the subject a therapeutic amount of a compound selected from GM1 and GD1a.
US Pat. No. 10,556,729

GAS BARRIER PACKAGING MATERIAL PRECURSOR AND GAS BARRIER PACKAGING MATERIAL

TOPPAN PRINTING CO., LTD....

1. A gas barrier packaging material precursor, comprising:a support;
an adhesion layer provided on one surface of the support;
a barrier layer and a protective layer formed adjacent to each other on the adhesion layer,
wherein said precursor has a laminated structure in which the adhesion layer, the barrier layer and the protective layer are formed in this order on the surface, alternatively, the adhesion layer, the protective layer, and the barrier layer are formed in this order on the surface;
wherein the adhesion layer contains a composite of a silicon compound having an isocyanate group or a hydrolysate of the compound, an acrylic polyol, or an isocyanate compound;
the barrier layer comprises a polycarboxylic acid polymer and at least one silicon compound (III) selected from the group consisting of a silane coupling agent represented by a general formula Si(OR)3Z, a hydrolysate thereof, and a condensate of these materials, wherein R denotes an alkyl group having 1 to 6 carbon atoms, Z denotes an organic group containing a glycidyloxy group or an amino group, and each R may be the same or different from each other;
wherein the protective layer being formed of a coating liquid containing a polyvalent metal compound, a polyester resin, and a dispersant; and the protective layer containing the polyvalent metal compound by about 40 to about 90 mass % relative to 100 mass % of the protective layer;
and wherein when the barrier layer is separated from the gas barrier packaging material precursor to measure an infrared absorption spectrum of the barrier layer by a transmission method, a ratio (?/?) of a maximum peak height (?) of absorbance in a range of about 1490 to about 1659 cm?1 to a maximum peak height (?) of absorbance in a range of about 1660 to about 1750 cm?1 is less than about 1,
wherein the acrylic polyol of the adhesion layer has a hydroxyl value in a range of 5 to 200 KOH mg/g.
US Pat. No. 10,559,805

BATTERY FOR AN ELECTRIC VEHICLE

GM Global Technology Oper...

1. A battery module for a battery pack, the battery module comprising:a plurality of first battery cells and a plurality of second battery cells that define a first lateral side, a second lateral side, an additional side and a center region between the plurality of first battery cells and the plurality of second battery cells;
a first outer bus bar disposed proximate to the first lateral side, and operatively configured to couple the plurality of first battery cells to a first outer connecting bus bar;
a second outer bus bar disposed proximate to the second lateral side, and operatively configured to couple the plurality of second battery cells to a second outer connecting bus bar;
a first inner bus bar disposed proximate to the center region, the first inner bus bar having a first proximate end and a first distal end, and the first proximate end is affixed to a corresponding first cell tab of the plurality of first battery cells; and
a second inner bus bar disposed proximate to the center region, the second inner bus bar having a second proximate end and a second distal end, and the second proximate end is affixed to a corresponding second cell tab of the plurality of second battery cells.
US Pat. No. 10,555,961

MATERIALS AND METHODS FOR TREATING BACTERIAL INFECTIONS USING C-1 GENTAMICIN

INDIANA UNIVERSITY RESEAR...

1. A method of treating a condition in a subject comprising administering a composition comprising C-1 gentamicin or a pharmaceutically acceptable acid addition salt thereof, wherein the composition is substantially free of C-1a gentamicin, C-2 gentamicin and C-2a gentamicin, and the condition is selected from the group consisting of a bacterial infection, a monogenic genetic disease and cancer.
US Pat. No. 10,555,963

KLOTHO PROTEIN AND RELATED COMPOUNDS FOR THE TREATMENT AND DIAGNOSIS OF CANCER

TEL HASHOMER MEDICAL RESE...

1. A method of treatment by inhibiting tumor growth or reducing tumor size in a subject having cancer, comprising administering to a subject in need thereof a pharmaceutically effective amount of a composition comprising an isolated polypeptide consisting of an amino acid sequence having at least 80% homology to the amino acid sequence represented by SEQ ID NO: 2, or a DNA encoding therefor, wherein the pharmaceutically effective amount is effective in inhibiting tumor growth or reducing tumor size in the patient.
US Pat. No. 10,556,989

END-MODIFIED POLYAMIDE RESIN AND METHOD FOR PRODUCING SAME

TORAY INDUSTRIES, INC., ...

1. An end modified polyamide resin containing 1 to 20% by mass of an end structure represented by general formula (I) below and 0.1 to 5% by mass of an end structure represented by general formula (II) below:—X—(R1—O)m—R2  (I)
wherein m represents 2 to 100; R1 represents a divalent hydrocarbon group having 2 to 10 carbon atoms, and R2 represents a monovalent hydrocarbon group having 1 to 30 carbon atoms; and —X— represents —NH—, —N(CH3)— or —(C?O)—; and m R1s in the general formula (I) may be the same or different, and
—Y—R3  (II)
wherein R3 represents a monovalent hydrocarbon group having 1 to 30 carbon atoms; and —Y— in the general formula (II) represents —(C?O)— when X in the general formula (I) is —NH— or —N(CH3)—, Y in the general formula (II) represents —NH— or —N(CH3)— when X in the general formula (I) is —(C?O)—.
US Pat. No. 10,556,225

METHODS OF REGENERATING AROMATIZATION CATALYSTS WITH A DECOKING STEP BETWEEN CHLORINE AND FLUORINE ADDITION

Chevron Phillips Chemical...

1. A method for regenerating a chlorinated spent catalyst comprising a transition metal and a catalyst support, the method comprising:(i) contacting the chlorinated spent catalyst with a decoking gas stream comprising oxygen to produce a de-coked chlorinated catalyst,
wherein the chlorinated spent catalyst comprises from about 0.5 wt. % to about 3 wt. % of chlorine; and
(ii) contacting the de-coked chlorinated catalyst with a fluorine-containing solution comprising a fluorine-containing compound in the liquid phase to produce a fluorinated catalyst; wherein:
the transition metal comprises a Group 8-11 transition metal; and
the catalyst support comprises a large pore zeolite having an average pore diameter in a range of from about 7 ? to about 12 ?.
US Pat. No. 10,556,993

ADDITION-CURABLE ORGANOPOLYSILOXANE RESIN COMPOSITION, CURED PRODUCT THEREOF, AND SEMICONDUCTOR DEVICE HAVING THE CURED PRODUCT

SHIN-ETSU CHEMICAL CO., L...

5. A cured product of an addition-curable organopolysiloxane resin composition comprising:(A) an organopolysiloxane having in one molecule at least two silicon-atom-bonded alkenyl groups each having 2 to 10 carbon atoms, said organopolysiloxane being present in an amount of 60 to 90% by mass per a total amount of components (A) to (D);
(B) an organohydrogenpolysiloxane having in one molecule at least two silicon-atom-bonded hydrogen atoms, said organohydrogenpolysiloxane being present in an amount of 5 to 40% by mass per the total amount of components (A) to (D);
(C) a platinum group metal-based catalyst, said platinum group metal-based catalyst being present in an amount of 0.00001 to 0.01% by mass in terms of platinum group metal per the total amount of components (A) to (D); and
(D) a barium compound that is present in an amount of 0.001 to 10.0% by mass per the total amount of components (A) to (D), wherein component (D) comprises at least one compound selected from dimethoxy barium, diethoxy barium, diisopropoxy barium, di-n-propoxy barium, di-n-butoxy barium, diisobutoxy barium, di-sec-butoxy barium, di-t-butoxy barium, barium octanoate, and barium 2-ethylhexanoate.
US Pat. No. 10,559,813

NEGATIVE ELECTRODE FOR NONAQUEOUS ELECTROLYTE SECONDARY BATTERY AND NONAQUEOUS ELECTROLYTE SECONDARY BATTERY

KABUSHIKI KAISHA TOYOTA J...

1. A negative electrode for nonaqueous electrolyte secondary battery, the negative electrode comprising:a current collector;
a negative electrode active material layer arranged on a surface of the current collector; and
a protective layer arranged on a top surface of the negative electrode active material layer;
the negative electrode active material layer including an active material layer binder, and a first negative electrode active material having an aspect ratio defined as “a”/“b” to fall in a range of from two or more to eight or less when a length of a major axis thereof is defined “a” and a length of a minor axis thereof is defined “b”;
the protective layer including a ceramic powder.
US Pat. No. 10,556,995

PROCESS FOR MAKING A COMPOSITION COMPRISING BENEFIT AGENT DELIVERY PARTICLES

1. A process of making a feedstock composition comprising benefit agent delivery particles, said process comprising the steps of:combining a graft co-polymer and a benefit agent to form a premix composition,
wherein said graft co-polymer is a co-polymer of polyalkylene glycol and vinyl acetate that comprises a polyalkylene glycol backbone comprising vinyl acetate moieties that are covalently attached to said polyalkylene glycol backbone,
wherein said benefit agent comprises perfume oil,
and
combining said premix composition and water to form said feedstock composition,
wherein said feedstock composition comprises less than about 98%, by weight of the feedstock composition, of water; and
wherein said benefit agent delivery particles comprise said graft co-polymer and said benefit agent.
US Pat. No. 10,555,971

COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF HLA MISMATCHED GRAFTS

The Board of Trustees of ...

1. A kit comprising components for an engineered hematopoietic cell product for establishing mixed chimerism in a solid organ transplant recipient, wherein the components of the engineered hematopoietic cell product comprise:an effective amount of CD34+ cells/kilogram recipient weight, wherein the CD34+ cells are derived from a donor that is of an HLA type that is mismatched to the solid organ transplant recipient's HLA type; and
more than 1×107 CD3+ T cells/kilogram recipient weight, wherein the CD3+ cells are derived from the donor that is of an HLA type that is mismatched to the solid organ transplant recipient's HLA type.
US Pat. No. 10,556,997

CROSS-LINKED RUBBER PRODUCT

ZEON CORPORATION, Tokyo ...

1. A cross-linked rubber product obtained by cross-linking an acrylic elastomer composition containing an acrylic elastomer obtained by copolymerization of an acrylate and a cross-linking site monomer having a carboxyl group,wherein a molar fraction of an oxygen atom (a) in the acrylic elastomer is 11.3 mol % or less,
a molar fraction of a nitrogen atom (b) in the acrylic elastomer is 0.5 mol % or less,
a content of n-butyl acrylate unit in a monomer unit constituting the acrylic elastomer is from 78 to 99.9% by weight, and
a volume change is from -3 to 6% when the cross-linked rubber product punched into a size of a length of 30 mm, a width of 20 mm, and a thickness of 2.0±0.2 mm is dipped in distilled water at 80° C. for 200 hours.
US Pat. No. 10,559,816

SURFACE-TREATED POSITIVE ELECTRODE ACTIVE MATERIAL FOR LITHIUM SECONDARY BATTERY, METHOD FOR PREPARING THE SAME, AND LITHIUM SECONDARY BATTERY COMPRISING THE SAME

LG Chem, Ltd., (KR)

1. A positive electrode active material for a lithium secondary battery comprising:lithium transition metal composite oxide particles; and
a coating layer including LiwNbxOy (1?w?8, 1?x?13, 1?y?20) formed on surfaces of the lithium transition metal composite oxide particles,wherein the lithium transition metal composite oxide particles are represented by the following Chemical Formula 1:Li1+z[NiaCobMnc]O2 (0?z?0.6, 0.6?a?1, 0?b, c?1, z+a+b+c=1), and  [Chemical Formula 1]
wherein the coating layer further includes Li2O—Nb2O5,
wherein the coating layer is included in 0.05% by weight to 3% by weight with respect to a total weight of the positive electrode active material.
US Pat. No. 10,559,817

SULFUR PARTICLES COATED WITH INORGANIC-ORGANIC HYBRID MEMBRANES AS CATHODE ACTIVE MATERIAL AND BATTERIES CONTAINING THE PARTICLES

1. A core-shell composite sulfur particle, comprising:a core of elemental sulfur comprising homogeneously dispersed particles of a conductive carbon and a polyelectrolyte polymer; and
a shell of a hybrid membrane comprising in sequence from a surface of the core, a layer of branched polyethyleneimine (bPEI), a layer of a negatively charged smectite clay nanosheet and a layer of bPEI on the layer of negatively charged smectite clay nanosheet encapsulating the core;
wherein the dispersed particles of conductive carbon are associated with the polyelectrolyte polymer of the elemental sulfur core, and
the polyelectrolyte polymer of the core is selected from the group consisting of a branched polyethyleneimine, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) and polyvinyl pyrrolidone (PVP).
US Pat. No. 10,555,975

PREVOTELLA HISTICOLA PREPARATIONS AND THE TREATMENT OF AUTOIMMUNE CONDITIONS

Mayo Foundation for Medic...

1. A powder composition comprising:(a) an anti-inflammatory effective amount of live Prevotella histicola or dead Prevotella histicola, and
(b) a botanical.
US Pat. No. 10,555,976

METHOD OF REDUCING THE LIKELIHOOD OF SKIN CANCER IN AN INDIVIDUAL HUMAN BEING

1. A method of reducing the likelihood of skin cancer in an individual human being, said method comprising: administering a therapeutically effective amount of a bacterial formulation comprising Nitrosomonas eutropha adapted to produce p53, said bacterial formulation comprising a lotion, ointment or gel adapted to be rubbed onto a region of an individual's skin wherein at least some bacteria in the bacterial formulation have been modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system to remove a virulence factor of the at least some bacteria.
US Pat. No. 10,555,978

COMPOSITION FOR INDUCING PROLIFERATION OR ACCUMULATION OF REGULATORY T CELLS

The University of Tokyo, ...

1. A pharmaceutical composition, comprising one or more purified live bacterial strains belonging to Clostridium clusters IV or XIVa,wherein the one or more bacterial strains induces proliferation and/or accumulation of regulatory T cells,
wherein the one or more bacterial strains are isolated from a human, and
wherein the pharmaceutical composition is formulated for delivery to the intestine.
US Pat. No. 10,557,005

PAINTED POLYOLEFIN ARTICLES

Dow Global Technologies L...

1. A painted article, comprising:a primer layer between a substrate and a paint layer, the substrate being the product of a substrate forming composition including at least 50 wt % of an olefin block copolymer, based on the total weight of the substrate forming composition, and a polypropylene polymer having a density from 0.89 g/cm3 and 0.92 g/cm3,
wherein the substrate is free of (1) phthalate-based plasticizer, (2) halogen-containing polymer, and (3) leachable, small polymeric units derived from styrene monomer, and
wherein the substrate forming composition comprises an alpha-olefin comonomer content of less than 9.7 mol %.
US Pat. No. 10,555,981

ONCOLYTIC VIRUS FOR EXPRESSION OF IMMUNE CHECKPOINT MODULATORS

Transgene S.A., Illkirch...

1. A method for treating a proliferative disease, comprising administering an oncolytic virus comprising inserted in its genome a nucleic acid molecule encoding one or more immune checkpoint modulator(s) wherein said virus is a vaccinia virus defective for Ribonucleotide reductase (RR) activity resulting from inactivating mutations in only the viral 14L gene and defective for thymidine kinase (TK) resulting from inactivating mutations in the J2R viral gene, wherein said one or more immune checkpoint modulator(s) is an antibody that specifically binds to PD-1 or a pharmaceutical composition comprising an effective amount of said oncolytic virus wherein said virus is a vaccinia virus defective for Ribonucleotide reductase (RR) activity resulting from inactivating mutations in only the viral 14L gene and defective for thymidine kinase (TK) resulting from inactivating mutations in the J2R viral gene, wherein said one or more immune checkpoint modulator(s) is an antibody that specifically binds to PD-1 and a pharmaceutical acceptable vehicle.
US Pat. No. 10,555,470

SOYBEAN CULTIVAR S160123

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S160123, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-25326.
US Pat. No. 10,555,982

COMPOSITION CONTAINING OROXYLIN A AND METHOD OF EXTRACTION THEREOF

SAMI LABS LIMITED, Banga...

1. A composition comprising 10%-15% w/w Oroxylin A, 10%-25% w/w Baicalein and 2%-10% w/w Chrysin, isolated from the bark of Oroxylum indicum.
US Pat. No. 10,555,472

INBRED CORN LINE IV7

Limagrain Europe S.A., S...

1. A seed of inbred corn line designated IV7, wherein a representative sample of seed of said line was deposited under ATCC Accession No. PTA 126032.
US Pat. No. 10,557,778

OPTICAL PROJECTION TOMOGRAPHY MICROSCOPY (OPTM) FOR LARGE SPECIMEN SIZES

1. A method to prepare a specimen of biological tissue for optical imaging, comprising:receiving a thin-needle core biopsy (TNCB) specimen of biological tissue, the TNCB specimen having an elongated shape;
preserving the elongated shape and integrity of the TNCB specimen during preparation of the TNCB specimen for optical imaging, said preparation including:
introducing the TNCB specimen into a specimen channel of a microfluidics device, the specimen channel structured to preserve the elongated shape and integrity of the TNCB specimen;
moving the TNCB specimen from the specimen channel into a specimen chamber of the microfluidics device while retaining the elongated shape and integrity of the TNCB specimen, wherein the specimen chamber is structured to preserve the elongated shape and integrity of the TNCB specimen; and
preparing the TNCB specimen within the specimen chamber for optical imaging such that the TNCB specimen will retain its elongated shape and integrity during said optical imaging.
US Pat. No. 10,557,013

COATING COMPOSITION COMPRISING SUBMICRON CALCIUM CARBONATE AND USE THEREOF

OMYA INTERNATIONAL AG, O...

1. Concrete, wood, paper, metal or board coated with a glossing and opacifying coating composition comprising:(i) at least one submicron ground natural calcium carbonate (SMGCC) having a volume median particle diameter d50 of 0.05 to 0.3 ?m and a d98 of less than or equal to 0.6 ?m, and titanium dioxide, wherein the titanium dioxide:SMGCC weight ratio in the composition is from 75:25 to 98:2, and wherein the calcium carbonate is calcite, marble, chalk or limestone; and
(ii) glossing and opacifying coating composition components,
wherein the glossing and opacifying coating composition has a pigment volume concentration (PVC) of from 5 vol.-% up to a critical pigment volume concentration (CPVC),
and wherein the glossing and opacifying coating composition, applied to a contrast card to form a layer having a thickness of 150 ?m or 300 ?m, has a gloss that is within ±3% of the gloss of the same composition and thickness in which the SMGCC is fully replaced with the titanium dioxide, when gloss is measured either at a 60° or an 85° incident angle according to DIN 67530.
US Pat. No. 10,555,988

ANTIMICROBIAL PEPTIDES, THEIR VARIANTS AND USES

Chain Antimicrobials Oy, ...

1. An antimicrobial peptide, comprising any one of synthetically prepared SEQ ID NOs: 55, 58, 59 and 61 to 65 peptide or said antimicrobial peptide defined by a peptide sequence having at least 90 identity to any one of SEQ ID NOs: 55, 58, 59 and 61 to 65.
US Pat. No. 10,557,015

EPOXY RESIN-EPOXY CURING SYSTEMS WITH A LATENT THICKENING TENDENCY

BYK-Chemie GmbH, Wesel (...

1. An adhesive, sealant, a coating material or a molding compound obtained from a two-component or multicomponent system comprisingat least one epoxy resin component 1 which comprises
i. at least one epoxy resin,
ii. at least one inorganic thickener (a1), and
iii. at least one wetting and dispersing agent (a2) which inhibits the thickening effect of the inorganic thickener (a1);witha curing agent component 2 which comprises
i.) at least one component (b1) which at least partly eliminates the inhibition of the thickening effect of the inorganic thickener (a1);
the wetting and dispersing agent (a2) being nonreactive toward the at least one epoxy resin and the curing agent component 2 being reactive toward the epoxy resin component 1;
wherein the at least one component (b1) is a polymer;
wherein in the resulting mixture of the epoxy resin component 1 and the curing agent component 2 the weight ratio of wetting and dispersing agent (a2) to component (b1) is 15:1 to 1:5;
wherein the curing agent component 2 comprises a curing agent different from and in addition to the at least one component (b1), said curing agent employed substantially stoichiometrically relative to the at least one epoxy resin; and
wherein the at least one epoxy resin component 1 and the curing agent component 2 of the two-component or multicomponent system represent two spatially separate individual components stored separately before mixing.
US Pat. No. 10,555,990

MESENCHYMAL STEM CELL DIFFERENTIATION

NOVARTIS AG, Basel (CH) ...

1. A polypeptide consisting of an amino acid sequence as set forth in any one of SEQ ID NO:5, SEQ ID NO:6, or SEQ ID NO:7, wherein said polypeptide is PEGylated.
US Pat. No. 10,555,480

SOYBEAN VARIETY 01068350

Monsanto Technology LLC, ...

1. A plant of soybean variety 01068350, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-125716.
US Pat. No. 10,555,992

IMMUNOGENIC PROTEINS AGAINST CLOSTRIDIUM DIFFICILE

University of South Flori...

1. An immunogenic protein comprising:i) a glucosyltransferase domain of Clostridium difficile toxin TcdB;
ii) a cysteine proteinase domain of Clostridium difficile toxin TcdB; and
iii) a receptor binding domain of Clostridium difficile toxin TcdA,
wherein the cysteine proteinase domain of Clostridium difficile toxin TcdB comprises a C698A amino acid substitution when compared to SEQ ID NO.: 8, and wherein the immunogenic protein lacks a transmembrane domain.
US Pat. No. 10,557,018

THREE-DIMENSIONAL OBJECT FORMING LIQUID, THREE-DIMENSIONAL OBJECT FORMING LIQUID SET, THREE-DIMENSIONAL OBJECT PRODUCING METHOD, AND THREE-DIMENSIONAL OBJECT

Ricoh Company, Ltd., Tok...

1. A three-dimensional object forming liquid,wherein the three-dimensional object forming liquid is a hydrogel precursor that comprises a multifunctional monomer, and
wherein a viscosity of the three-dimensional object forming liquid is from 3 mPa·s to 20 mPa·s at 25° C., and an 80% strain compressive stress of a hydrogel obtained by curing the three-dimensional object forming liquid is 0.4 MPa or greater.
US Pat. No. 10,555,993

DIMETHYL FUMARATE AND VACCINATION REGIMENS

Biogen MA Inc., Cambridg...

1. A method of treating multiple sclerosis in a human subject in need thereof, said method comprising:(a) administering to the subject a first dose of a pharmaceutical composition for a first dosing period, wherein the pharmaceutical composition comprises a fumarate agent selected from the group consisting of monomethyl fumarate, a pharmaceutically acceptable salt of monomethyl fumarate, dimethyl fumarate, and a combination thereof;
(b) administering a vaccine to the subject, wherein the subject receives the vaccine during the first dosing period; and
(c) administering to the subject a second dose of the pharmaceutical composition for a second dosing period, wherein: (i) the second dosing period is after the first dosing period, and (ii) the second dosing period is initiated within one day of the end of the first dosing period;
wherein the second dose is the same as the first dose, and the first dose and the second dose are administered daily;
wherein the multiple sclerosis is a relapsing form of multiple sclerosis;
wherein the first dose is a therapeutically effective amount of monomethyl fumarate, a pharmaceutically acceptable salt of monomethyl fumarate, dimethyl fumarate, or a combination thereof; and
wherein the vaccine induces (a) a T cell-dependent anamnestic humoral immune response, (b) a T cell-dependent neoantigen immune response, or (c) a T cell-independent immune response.
US Pat. No. 10,555,482

SOYBEAN VARIETY 01068427

Monsanto Technology LLC, ...

1. A plant of soybean variety 01068427, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-125718.
US Pat. No. 10,555,994

PCV2 ORF2 CARRIER PLATFORM

1. A recombinant polypeptide selected from the group consisting of:a) a PCV2 ORF2 protein characterized in that at least one amino acid residue in the BC loop is replaced by an amino acid sequence of interest;
b) a PCV2 ORF2 protein characterized in that an amino acid sequence of interest is inserted into the BC loop; or
c) a combination of a) and b);wherein the amino acid sequence of interest comprises SEQ ID NO: 5 or 7.
US Pat. No. 10,555,483

SOYBEAN VARIETY 01067598

Monsanto Technology LLC, ...

1. A plant of soybean variety 01067598, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-125765.
US Pat. No. 10,557,021

ARTIFICIAL TIMBER AND METHOD FOR PREPARING ARTIFICIAL TIMBER

1. A method for preparing an artificial timber, comprising steps of:(1) dissolving 15 to 35 parts by weight of lignin, 35 to 50 parts by weight of cellulose and 20 to 35 parts by weight of hemicellulose to form a lignocellulose, and
adding the lignocellulose into an ionic liquid, and heating and stirring for dissolving to obtain a lignocellulose ionic liquid dispersion;
(2) cleaning and replacing the ionic liquid with water to obtain a lignocellulose hydrogel; and
(3) drying the lignocellulose hydrogel to obtain an artificial timber.
US Pat. No. 10,555,996

THERAPEUTIC HPV16 VACCINES

1. A recombinant pox virus vector comprising a nucleic acid sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:1, wherein the nucleic acid sequence is operably linked to a promoter.
US Pat. No. 10,557,023

CABLE INSULATION COMPRISING A BLEND OF LDPE AND POLYPROPYLENE

Dow Global Technologies L...

1. A composition comprising, in weight percent based on the weight of the composition:(A) 85 to 99% low density polyethylene (LDPE) having a crystallinity of greater than 40%;
(B) 1 to less than 14% propylene polymer having an upper melting point of greater than or equal to (?) 130° C.; and
(C) ?0.5% peroxide.
US Pat. No. 10,555,486

SOYBEAN VARIETY 01068910

Monsanto Technology LLC, ...

1. A plant of soybean variety 01068910, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-125731.
US Pat. No. 10,555,998

INACTIVATED EQUINE INFLUENZA VIRUS VACCINES

Intervet Inc., Madison, ...

1. An isolated equine influenza virus (EIV) isolate comprising a genome that encodes a hemagglutinin protein (HA) comprising an amino acid sequence that comprises 95% or greater identity with the amino acid sequence of SEQ ID NO: 2; wherein the amino acid sequence of the HA:comprises an amino acid residue at position 222 other than that of a tryptophan or an arginine, and either an amino acid residue at position 223 other than that of a valine, or an amino acid residue at position 188 other than that of an asparagine; or
comprises an amino acid residue at position 222 other than that of a tryptophan or an arginine, an amino acid residue at position 223 other than that of a valine, and an amino acid residue at position 188 other than that of an asparagine;
wherein said EIV has been inactivated through being killed in an unnatural manner.
US Pat. No. 10,556,256

ANTIBACTERIAL WATER

TAKEDA PHARMACEUTICAL COM...

6. A method of producing nano-bubble water comprising not less than 2.0×108 bubbles/mL of nanobubbles, comprising forcedly dissolving a gas in the presence of polysorbate 80 and/or poly(vinyl alcohol) in a pressurized container, flashing the gas into nano-bubble water through a nozzle, whereby the gas is supersaturated by depressurization and released as a mixture of micro-bubbles or nano-bubbles in the nano-bubble water, and allowing the micro-bubbles to naturally float and be released from the nano-bubble water, to produce the nano-bubble water comprising not less than 2.0×108 bubbles/mL of nanobubbles.
US Pat. No. 10,555,487

SOYBEAN VARIETY 01067694

Monsanto Technology LLC, ...

1. A plant of soybean variety 01067694, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-125772.
US Pat. No. 10,557,026

COMPOSITION COMPRISING POLYPROPYLENE, POLYETHYLENE, AND A COMPATILIZER

SABIC GLOBAL TECHNOLOGIES...

1. A composition comprising polypropylene, polyethylene and a compatibiliser, wherein said compatibiliser is a non-aromatic polyester having an average M/E ratio of at least 10, wherein M is the number of backbone carbon atoms in the polyester not including the carbonyl carbons and E is the number of ester groups in the polyester.
US Pat. No. 10,556,001

THERMAL INACTIVATION OF ROTAVIRUS

The united States of Amer...

1. A method of inducing an immune response to rotavirus in a subject, comprising:administering to the subject a therapeutically effective amount of a vaccine composition, wherein the vaccine composition comprises:
a) an antigenic thermally-inactivated rotavirus that has a substantially intact rotavirus particle structure, wherein the substantially intact rotavirus particle structure is triple-layer rotavirus particles, double-layer rotavirus particles, or a combination of triple-layer rotavirus particles and double-layer rotavirus particles, and wherein the antigenic thermally-inactivated rotavirus is produced by the process of
suspending isolated rotavirus particles in an aqueous buffer, the aqueous buffer having an osmolality in the range of about 200-500 mOsm, comprising a concentration of a salt of a divalent cation in the range of about 1 mM-15 mM and an amount of a sugar and/or sugar alcohol in the range of about 1-20% w/v to produce a starting preparation of rotavirus particles having an intact rotavirus particle structure;
exposing the starting preparation of rotavirus particles to a temperature in the range of about 50° C.-73° C., inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection, wherein the incubation time is in the range of about 30 minutes to 24 hours inclusive, thereby producing the thermally-inactivated rotavirus;
b) an adjuvant; and
c) a sterile pharmaceutically acceptable carrier,
thereby inducing the immune response to the rotavirus in the subject.
US Pat. No. 10,555,490

SOYBEAN CULTIVAR 85370909

Monsanto Technology LLC, ...

1. A plant of soybean cultivar 85370909, representative seed of said soybean cultivar having been deposited under NCMA Accession No. 201909031.
US Pat. No. 10,557,797

METHOD TO DETECT BERYLLIUM BY OPTICAL FLUORESCENCE

AJJER L.L.C., Tucson, AZ...

1. A method of determining a presence or an amount of beryllium or beryllium compound in a sample comprising:(a) extracting the beryllium or the beryllium compound from the sample into a liquid medium unless the sample itself is a liquid medium;
(b) combining the liquid medium comprising the beryllium or the beryllium compound with a second solution creating a mixture, wherein the second solution contains a fluorescent indicator and a pH of the second solution is greater than 12.9 and;
(c) measuring optical fluorescence of the mixture, and correlating the optical fluorescence of the mixture with the presence or the amount of the beryllium or the beryllium compound within said mixture wherein the second solution with the fluorescent indicator contains no buffer.
US Pat. No. 10,555,492

SOYBEAN CULTIVAR 81430038

Monsanto Technology LLC, ...

1. A plant of soybean cultivar 81430038, representative seed of said soybean cultivar having been deposited under NCMA Accession No. 201909019 .
US Pat. No. 10,556,004

IMMUNOPOTENTIATOR

TORAY INDUSTRIES, INC., ...

1. A method for immunopotentiation, comprising administering in vivo an immunopotentiator as an active ingredient to an organism or a subject,wherein the immunopotentiator comprises, as an active ingredient, a modified ?-glucan in which ?-glucan having immunopotentiating effect and poly(hydroxy acid) are covalently bonded, and
wherein ?-glucan is a polymer of glucose linked by at least one ?-1,3 bond and/or at least one ?-1,6 bond.
US Pat. No. 10,559,850

NONAQUEOUS ELECTROLYTE COMPOSITIONS COMPRISING CYCLIC SULFATES

Solvay SA, Brussels (BE)...

1. An electrolyte composition comprising:a) an organic carbonate selected from ethylene carbonate and/or propylene carbonate;
b) a fluorinated acyclic carboxylic acid ester selected from CH3—COO—CH2CF2H;
c) a cyclic sulfate selected from one of ethylene sulfate or propylene sulfate; and
d) at least one electrolyte salt;
wherein the electrolyte composition comprises about 0.5 weight percent to about 3 weight percent of the cyclic sulfate.
US Pat. No. 10,555,494

ALFALFA VARIETY R410A131

Forage Genetics Internati...

1. A seed of alfalfa variety R410A131, wherein representative seed of said alfalfa variety have been deposited under ATCC Accession No. PTA-125606.
US Pat. No. 10,556,006

COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE

TAIGA BIOTECHNOLOGIES, IN...

1. A method of treating a viral infection, comprising administering to an individual in need thereof a fusion peptide comprising:a. a transporter peptide sequence; and
b. a MYC polypeptide sequence,wherein the transporter peptide sequence transports the fusion peptide into the nucleus of an immune cell in the individual.
US Pat. No. 10,555,495

ALFALFA VARIETY R410A136

Forage Genetics Internati...

1. A seed of alfalfa variety R410A136, wherein representative seed of said alfalfa variety have been deposited under ATCC Accession No. PTA-125607.
US Pat. No. 10,556,007

ANTIBODY WHICH BINDS LRG1 AND METHODS OF USE

UCL Business LTD, London...

1. An antibody or fragment thereof that specifically binds to human Lrg1 and which comprises CDRs of SEQ ID NOs: 21, 22, 23, 24, 25, and 26.
US Pat. No. 10,557,034

IONIZING-RADIATION-RESISTANT POLYCARBONATE RESIN COMPOSITION, AND MOLDED PRODUCT COMPRISING SAME

Lotte Advanced Materials ...

1. A polycarbonate resin composition comprising:about 100 parts by weight of a polycarbonate resin;
about 0.001 to about 5 parts by weight of a polyalkylene glycol;
about 0.001 to about 3 parts by weight of an epoxy ester compound containing an ester group and an epoxy group; and
about 0.01 to about 5 parts by weight of a halogenated polycarbonate oligomer.
US Pat. No. 10,555,497

PEPPER HYBRID DRPB2628 AND PARENTS THEREOF

Seminis Vegetable Seeds, ...

1. A pepper plant comprising at least a first set of the chromosomes of pepper line SBY-XD15-0123GMS, a sample of seed of said line having been deposited under ATCC Accession Number PTA-125003.
US Pat. No. 10,556,009

ANTI-BLYS ANTIBODY FORMULATIONS AND METHODS OF TREATMENT USING THEM

GlaxoSmithKline Intellect...

1. A pharmaceutical formulation for an antigen binding protein comprising:a. 200±20 mg/mL of the antigen binding protein;
b. about 5-15 mM of a buffering agent which is histidine providing a pH of 6.0±0.5;
c. about 115+10 mM of a tonicity agent which is sodium chloride;
d. about 20-30 mM of a stabilizer which is arginine; and
e. about 0.005 to 0.015% (w/v) of a nonionic surfactant which is polysorbate 80;wherein the antigen binding protein comprises amino acid sequences CDRH1 of SEQ ID NO:11, CDRH2 of SEQ ID NO: 12, CDRH3 of SEQ ID NO:13, CDRL1 of SEQ ID NO:14, CDRL2 of SEQ ID NO:15, and CDRL3 of SEQ ID NO:16.
US Pat. No. 10,557,035

RESIN COMPOSITION FOR HIGH FREQUENCY ELECTRONIC COMPONENTS

SABIC Global Technologies...

1. A resin composition comprising:(a) 40-90% by weight of a poly(arylene ether);
(b) 0-40% by weight of high-impact polystyrene (HIPS) and 0-40% by weight of general-purpose polystyrene (GPPS), provided that the HIPS, the GPPS, or the combination thereof represents 5-40% by weight of said composition;
(c) 5-25% by weight of an impact modifier; and,
(d) 15-400% by weight of a ceramic filler, as measured per 100 parts by weight of components (a)-(c),
wherein components (a)-(c) are each expressed relative to the total weight of components (a)-(c), and
wherein the resin composition exhibits a Df value of 8.7 e-4 to 1.2 e-3 when evaluated at 1.1 GHz using a split post dielectric resonator on a minimum sample size of 120 millimeter (mm) by 120 mm and a maximum sample thickness of 6 mm.
US Pat. No. 10,557,036

METAL-BASED HYDROGEN SULFIDE SCAVENGER AND METHOD OF PREPARING SAME

BAKER HUGHES, A GE COMPAN...

1. A composition comprising: asphalt or asphalt mix; and a dispersion of a hydrogen sulfide scavenger in an organic solvent, wherein the dispersion further comprises an organoclay suspension agent and an emulsifier, and wherein the proportion of the hydrogen sulfide scavenger is between 0.01% and 5% by weight with respect to the total weight of the asphalt composition.
US Pat. No. 10,556,011

METHOD AND SYSTEM FOR ADDING SENSORY CONDITIONING CUES IN A PHARMACOTHERAPEUTIC REGIMEN

1. An opioid administration kit, comprising:a sequential order of medicine amounts, wherein each said medicine amount in the sequential order is in a unitary form and includes a dose of at least one opioid and an amount of at least one non-active pharmacological agent (NPA), wherein the amount of NPA is configured to provide at least one non-visual sensory cue; and
wherein the opioid dose in each medicine amount within the sequential order is greater than the dose of opioid contained within the next medicine amount within the sequential order, and each medicine amount in the sequential order contains substantially the same amount of the NPA, and wherein the opioid dose in each medicine amount is a prescription drug; and
packaging configured to hold the medicine amounts and indicate the sequential order of the medicine amounts.
US Pat. No. 10,557,039

COMPOSITIONS COMPRISING BISPHOSPHONIC COMPOUNDS DISSOLVED IN A FLUORINATED SOLVENT, AND USE THEREOF FOR COVERING THE SURFACE OF A PART

Surfactis Technologies, ...

1. A liquid composition containing at least one bisphosphonic compound bearing at least one partially fluorinated, perfluorinated (PF) or perfluoropolyether (PFPE) group, wherein said bisphosphonic compound is dissolved in a nonflammable fluorinated solvent or in a mixture of nonflammable fluorinated solvents.
US Pat. No. 10,557,040

ANTI-CORROSION COATINGS LOADED WITH MESOSTRUCTURED PARTICLES

AIRBUS, Blagnac (FR)

1. A coating comprising at least one layer comprising individual and mesostructured spherical micrometric particles, said mesostructured spherical micrometric particles being loaded with at least one element selected from among functional corrosion-inhibiting molecules and functional corrosion-inhibiting nano-objects and formed by a continuous non-dissociable nebulization of a liquid solution at a predetermined molar concentration in a solvent to obtain a fog of solution droplets and heating the fog solution droplets to evaporate the solvent and volatile compounds in a single reactor, the liquid solution comprising one or more precursors from a three-dimensional network of particles and said at least one element chosen from the functional corrosion-inhibiting molecules and the functional corrosion-inhibiting nano-objects; and wherein said at least one layer is a sealed hybrid organic-inorganic layer, containing a sol-gel or sealed primer layer, that is closed and sealed to limit penetration of corrosive materials.
US Pat. No. 10,556,015

LYSOSOMAL TARGETING OF ENZYMES, AND USES THEREOF

Criteo S.A., Paris (FR)

1. A targeted therapeutic fusion protein comprising a lysosomal enzyme fused to a lysosomal targeting moiety comprising a proprotein convertase subtilisin kexin type 9 (PCSK9) protein comprising amino acid substitutions S386A and F379A.
US Pat. No. 10,557,041

ANTI-CORROSION COMPOSITION COMPRISING POLYISOBUTYLENES

1. Anti-corrosion composition comprising:at least a first polyisobutylene with a Staudinger index J0 ranging from about 15 cm3/g to about 98 cm3/g and an average relative molar mass Mv ranging from about 32,000 g/mol to about 280,000 g/mol and at least a second polyisobutylene with a Staudinger index J0 ranging from about 105 cm3/g to about 238 cm3/g and an average relative molar mass Mv ranging from about 350,000 g/mol to about 900,000 g/mol and at least a third polyisobutylene with a Staudinger index J0 ranging from about 240 cm3/g to about 900 cm3/g and an average relative molar mass Mv ranging from about 950,000 g/mol to about 5,500,000 g/mol.
US Pat. No. 10,556,016

ARTIFICIAL ANTIGEN-PRESENTING CELLS AND METHODS FOR PRODUCING AND USING THE SAME

Indiana University Resear...

1. A biomimetic Janus particle comprising:a) a particle;
b) at least one substantially concentric pattern of a first ligand population bound to the particle, wherein the first ligand population comprises one or more ligands involved in T cell activation and/or one or more molecules to which a ligand involved in T cell activation may be bound; and
c) a second ligand population bound to the particle, wherein the second ligand population is different than the first ligand population and does not substantially overlap the substantially concentric pattern of the first ligand population, and wherein the second ligand population comprises one or more ligands involved in T cell activation and/or one or more molecules to which a ligand involved in T cell activation may be bound,
wherein one of the first ligand population or second ligand population comprise an integrin-binding ligand.
US Pat. No. 10,557,042

SLIPPERY LIQUID-INFUSED POROUS SURFACES THAT PREVENT MICROBIAL SURFACE FOULING

Wisconsin Alumni Research...

1. A slippery liquid-infused porous surface (SLIPS) that controllably releases a molecule, wherein said slippery oil-infused surface comprises:a) a porous matrix having nanoscale or microscale porosity;
b) an oil covering at least a portion of the porous matrix, wherein said oil at least partially fills the pores of the porous matrix; and
c) one or more small-molecule compounds, wherein the one or more small-molecule compounds are located on the surface or in said porous matrix, within said oil, or both,
wherein the slippery oil-infused surface is able to controllably release the one or more small-molecule compounds when the slippery oil-infused surface is immersed into media.
US Pat. No. 10,556,019

HUMAN MICRORNAS FOR TREATMENT OF MALIGNANT TUMOURS

1. A method of treatment of breast cancer, comprising:administering to a subject in need thereof a therapeutically effective amount of a nucleic acid molecule consisting essentially of a sequence selected from the group consisting of SEQ ID NO 001 and SEQ ID NO 002,wherein the nucleic acid molecule initiates apoptosis in cancerous cells, thereby treating the breast cancer.
US Pat. No. 10,556,020

RNA-MODULATING AGENTS

UNIVERSITY OF MASSACHUSET...

1. An RNA-modulating agent comprising an mRNA binding sequence that is complementary to a portion of a target mRNA sequence, linked to two or more miRNA binding sequences, wherein one or more of the miRNA binding sequences are complementary to positions 2 to 8, and 12 to 15, 12 to 16, or 12 to 17 of the miRNA, but not complementary to positions 1, 10 and 11 of the miRNA.
US Pat. No. 10,557,051

METHOD FOR PRODUCING AN INK, INK, AND USE OF SAME

FORSCHUNGSZENTRUM JUELICH...

1. A method for producing an ink, comprising:a) producing, via a wet milling process using a first solvent, nanoparticles having a size of 0.1 to 20 nm;
b) covalently bonding, by coupling reactions, short-chain, branched organic stabilizer molecules to surfaces of the nanoparticles to form stabilized nanoparticles; and
c) forming the ink by dissolving the stabilized nanoparticles in a second solvent and dispersing the stabilized nanoparticles in the second solvent.
US Pat. No. 10,557,053

UNIVERSAL PIGMENT PREPARATIONS FOR POINT-OF-SALE USE

BASF SE, Ludwigshafen (D...

1. A pigment preparation comprising, based in each case on the total weight of the preparation,(A) 1 to 80 wt % of a pigment component which comprises a pigment and optionally a filler;
(B) 0.01 to 10 wt % of a water-soluble, anionic, surface-active additive selected from the group consisting of homo- and copolymers of ethylenically unsaturated monocarboxylic acids and/or ethylenically unsaturated dicarboxylic acids, which may further comprise, in copolymerized form, vinyl monomers comprising no acid function, and of the salts of the homo- and copolymers, the homo- and copolymers being at least partly esterified with a polyether alcohol or a derivative thereof;
(C) 0.01 to 8 wt % of a phosphoric ester of the formula (I):
[RO—(C2-C3-alkylene oxide)y]x-PO(OH)3-x  (I)
wherein
the radical R independently at each occurrence is linear or branched C8-C22-alkyl, C8-C22-alkenyl or phenyl which may be substituted by C1-C12-alkyl, styryl or methyl-substituted styryl,
the (C2-C3-alkylene oxide) group is ethylene oxide and/or propylene oxide,
x=1 or 2, and
y=1-100;
(D) 0 to 20 wt % of one or more further additives customary for aqueous pigment preparations; and
(E) water,
where the sum of the percentages by weight of components (A) to (E) makes 100 wt %.
US Pat. No. 10,556,798

SYNTHESIS OF FLUORINATED GRAPHENE OXIDE FOR ELECTROCHEMICAL APPLICATIONS

LAKEHEAD UNIVERSITY, Thu...

1. A method for synthesis of about 0.5 to about 1.5 at. % fluorinated grapheme oxide comprising:mixing about n grams of graphite with about 5*n to about 40*n ml HF in a solution of about 50*n to about 150*n ml of H2SO4/H3PO4 at a ratio of 10-x:x, where x=0.1 to 4 with stirring at a temperature of about 30 to about 80° C. for a first period of time to generate a first mixture;
adding about 3*n to about 10*n g KMnO4 to the first mixture to generate a second mixture and stirring the second mixture at a temperature of about 40 to about 80° C. for a second period of time;
adding the second mixture to a container containing about 50*n to about 250*n ml of ice and about 1*n to about 10*n ml of H2O2 to generate a third mixture;
separating solid comprising about 0.5 to about 1.5 at. % fluorinated grapheme oxide from the third mixture;
rinsing the fluorinated graphene oxide; and
drying the fluorinated graphene oxide.
US Pat. No. 10,556,799

TRITERTBUTYL ALUMINUM REACTANTS FOR VAPOR DEPOSITION

ASM IP HOLDING B.V., Alm...

1. A deposition reactor comprising a first reactant container fluidly connected to a reaction chamber, the reactant container comprising a first precursor composition comprising at least 50% Isomer 1, at least 50% Isomer 2, or at least 20% of a combination of Isomer 1 and Isomer 2 of Al(tert-Bu)3, wherein Isomer 1 has the formula Al(tert-Bu)2(iso-Bu) and Isomer 2 has the formula Al(tert-Bu)(iso-Bu)2.
US Pat. No. 10,557,055

CONFORMABLE COATING COMPOSITION COMPRISING FLUORINATED COPOLYMER

3M Innovative Properties ...

1. A conformable coating composition comprising:a (meth)acrylate copolymer comprising interpolymerized monomer units of 2,2,2-trifluoroethyl acrylate in an amount ranging from 10-40 wt-% based on the weight of the (meth)acrylate copolymer; and
a volatile solvent having a solubility parameter from 4.9-12.5 (cal/cm3)1/2, wherein the volatile solvent is selected from the group consisting of volatile linear and cyclic siloxanes, volatile polydimethylsiloxanes, isooctane, octane, and combinations thereof, and
wherein the conformable coating composition is free of polymerizable cyanoacrylate monomer.
US Pat. No. 10,557,057

HIGH MELT FLOW PAEK COMPOSITIONS

SOLVAY SPECIALTY POLYMERS...

1. A composition (C) comprising:a. from 20 to 80% by weight (wt. %) of at least one poly(aryl ether ketone) polymer, (PAEKHMF) polymer, having a melt flow rate (MFR) from 15 g/10 min to 80 g/10 min at 400° C. and under a load of 2.16 kg, as measured in accordance with ASTM method D1238;
b. from 12 to 30 wt. % of at least one poly(tetrafluoroethylene) polymer, (PTFE) polymer, having a D50 particle size from 2 to 8 ?m, and having a melting temperature (TmII) from 321° C. to about 324° C.; and
c. from 10 to 30 wt. % of at least one carbon fiber,
and wherein all wt. % are based on a total weight of the composition (C).