US Pat. No. 10,246,877

ARRANGEMENT FOR VENTILATING A LABORATORY ROOM

WOBATECH AG, Wollerau (D...

1. A laboratory ventilation arrangement, comprisinga laboratory table row defining at least a first walking area and a second walking area on a first side and a second side of the laboratory table row,
a plurality of center carrier elements configured to be in a spaced arrangement along the length of the table row and suspended above the laboratory table row;
wherein each center carrier element comprises a vertical column element having an upper end adapted to be fastened to a ceiling of a laboratory, and a lower end having horizontal extensions comprising a first extension arm extending toward a first side of the table row and a second extension arm extending toward the second side of the table row and over an area occupied by the laboratory table row,
a first air supply conduit and a second air supply conduit having a plurality of air exit openings;
wherein the first air supply conduit is received on a bottom portion of the first extension arm and the second air supply conduit is received on a bottom portion of the second extension arm, the first and second air supply conduits being arranged along the first and second extension arms at a horizontal interval to define a lower receiving space between the first and second air supply conduits extending parallel to the first and second air supply conduits over a length of the laboratory table row and adapted to provide receiving space for supply lines;
an exhaust air conduit;
wherein the exhaust air conduit is a first side exhaust air conduit carried by a plurality of side carrier elements having a side vertical column element and a side extension arm fastened to the side vertical column element; and
wherein the exhaust air conduit is arranged on the plurality of side carrier elements in a space separated from the first air supply conduit or the second air supply conduit.

US Pat. No. 10,246,876

ADJUSTABLE BRACKET FOR RAISING A PATIO ROOF AND METHOD OF USE

1. An adjustable bracket for raising a patio roof, comprising:a. an attachment mechanism attachable to a fascia or a rafter;
b. a bracket mechanism configured to extend from and raise, support, and attach a patio roof member or a joist at least 12 inches above a bottom of the fascia or a bottom of the rafter;
c. an adjustment mechanism to provide an adjustment angle of the bracket mechanism relative to the attachment mechanism to accommodate different roof angles,
wherein the attachment mechanism includes a rectangular flat plate that is coupleable to the fascia or the rafter, parallel flanges extending perpendicularly from the plate, and the flanges each include a hole that receives a fastener to secure the adjustment angle of the bracket mechanism relative to the attachment mechanism,
the bracket mechanism includes elongated parallel side walls having a proximal end adjacent to the attachment mechanism and a distal end configured to raise, support, and attach the patio roof member or the joist,
the parallel flanges of the attachment mechanism and the elongated parallel side walls of the bracket mechanism pivotally connected to each other at a first location along the elongated parallel side walls of the bracket mechanism adjacent to the proximal end of the bracket mechanism, and movably securable to each other at a second location along the elongated parallel side walls of the bracket mechanism that is distal to the first location and proximal to the distal end of the bracket mechanism.

US Pat. No. 10,246,874

METAL DECKING

PATCO, LLC, Arvada, CO (...

1. A metal deck comprising:a plurality of deck components formed in a contiguous metal sheet, one or more of the deck components formed along a width of the metal deck and including an elevated section and a ribbed section, the elevated section configured to provide sound insulation between the metal deck and a truss structure, the ribbed section including a rib flute extending from a bottom surface of the metal deck, the ribbed section further including a first elevated rib positioned adjacent to a first side of the rib flute and a second elevated rib positioned adjacent to a second side of the rib flute, the first elevated rib and the second elevated rib being substantially parallel to the rib flute, the ribbed section including the rib flute, the first elevated rib, and the second elevated rib extending along a length of the metal deck.

US Pat. No. 10,246,873

INSULATED STRUCTURAL MEMBERS FOR INSULATED PANELS AND A METHOD OF MAKING SAME

KPS GLOBAL LLC, Fort Wor...

1. An insulated veneer panel system, comprising:an insulated panel formed of closed cell polyurethane foam disposed between sheathing material on first and second faces of the insulated panel, the insulated panel defined by first and second sides;
an elongated hybrid structural member, formed of an elongated core member and a high density insulating material, disposed against at least one of the first and second sides of the insulated panel;
the core member having a cross section defined by at least a length and a width, wherein the length and the width define a surface area at each end of the core member;
wherein the high density insulating material of the elongated structural member substantially covers at least two surfaces defined by the length, width, and surface area at each end of the core member, thereby forming a hybrid structural member.

US Pat. No. 10,246,870

CONSTRUCTION VENTING STRIP

1. A construction venting strip, comprising:a linear, planar, base strip made of a polymer, said base strip having a width, a length, a linear axis, two parallel linear edges, a planar top face and a planar bottom face, said top face having an area;
a series of equal height support fins extending from said top face;
a venting space defined there between said support fins extending across said width of said strip;
wherein said planar base strip and said support fins are made of a polymer having a hardness in the Shore A Durometer scale range of 60-80, and
wherein said support fins are arranged in a repeating pattern that incorporates six cut lines across the width of said construction venting strip.

US Pat. No. 10,246,869

CONSTRUCTION ASSEMBLY AND METHOD FOR MAKING AND USING THE SAME

ELEVATE STRUCTURE INC., ...

1. A construction assembly, comprising:a plurality of primary structure members radially distributed about a center region, each having an S shape defining first and second level recesses, each primary structure member being in a standing position with the first and second level recesses being respectively proximal to and distal from ground, each primary structure member including:
a first floor portion parallel to the ground;
a first wall portion connected with and vertical to the first floor portion;
a second floor portion connected to the first wall portion and parallel to the first floor portion, the first floor portion, the first wall portion and the second floor portion collectively defining the first level recess;
a second wall portion connected to the second floor portion and parallel to the first wall portion; and
a ceiling portion connected to the second wall portion and parallel to the first floor portion, the second floor portion, the second wall portion and the ceiling portion collectively defining the second level recess;
a second level ring joining the second floor portion of each of the primary structure members;
a ceiling ring joining the ceiling portion of each of the primary structure members; and
a foundation located between the first floor portion and the ground, said foundation including:
a plurality of channel members each receiving the first floor portion of one of the primary structure members; and
a foundation panel located between every two adjacent channel members,
the first wall portions collectively surrounding and defining a first level space and the second wall portions collectively surrounding and defining a second level space greater than the first level space,
wherein the first floor portion terminates at a base terminal region that is rotatably coupled with the channel member at a pivot point, the primary structure member being configured to convert from the standing position to a laying position by pivoting as a whole about the pivot point such that the first floor portion pivots from the ground to a non-parallel position relative to the ground.

US Pat. No. 10,246,868

MODULAR PLATFORM ASSEMBLY AND A METHOD OF ASSEMBLING A MODULAR PLATFORM

1. A modular platform assembly, including:a plurality of legs;
a plurality of floor beams; and
a plurality of connectors for connecting the legs and the floor beams, each said connector comprising:
a downwardly open blind recess with a closed top end and an open bottom end; and
an upwardly open blind recess with a closed bottom end and an open top end,
wherein the legs are mounted into the downwardly open blind recesses of the connectors and the floor beams are mounted into the upwardly open blind recesses of the connectors such that the legs extend downwardly from the floor beams, and wherein an outer cross sectional periphery of at least one of the legs is substantially the same as an outer cross sectional periphery of at least one of the floor beams, and wherein each said beam has a top surface, the closed top ends of the downwardly open blind recesses and the top surfaces of the beams together defining a plane.

US Pat. No. 10,246,866

TOILET FASTENING ASSEMBLY AND METHOD

1. A toilet fastening assembly comprising:a fastener having a base at a proximal end, a support extending from the base, and a threaded shaft extending from the support to a distal end, the base including two flat surfaces interconnecting two curved surfaces, the support including two flat surfaces interconnecting two tapered surfaces, wherein the two flat surfaces of the support are aligned with the two flat surfaces of the base, wherein the threaded shall includes two distal tapered surfaces at the distal end, and wherein the two distal tapered surfaces are positioned perpendicular to the two flat surfaces of the base and the two flat surfaces of the support; and
a cap having an outer wall extending from a proximal end to a distal gripping end, the proximal end including a proximal opening leading to an inner cavity defined by the outer wall, the cap further including an inner cylindrical wall extending from the distal gripping end to a proximal end disposed within the inner cavity, the inner cylindrical wall including an threaded inner surface configured to receive the threaded shaft of the fastener, wherein the proximal end of the inner cylindrical wall is recessed by a recess distance relative to the proximal end of the outer wall.

US Pat. No. 10,246,864

PRESSURE TOILET WITH BULK LOADING SIPHON ASSIST

KOHLER CO., Kohler, WI (...

1. A toilet comprising a bowl and a pressurized water supply with a channel for injecting water under pressure into a trapway, the trapway extending between a bowl opening and an outlet and having an up leg extending upward and rearward from the bowl opening to a water dam region above the bowl opening to a down leg sloping downward and forward to communicate with the outlet, wherein the trapway includes a baffle extending forward from a forwardmost portion of a rear wall of the down leg adjacent a lower portion of the down leg, wherein the toilet effects a siphon if a threshold concentration of bulk waste material is present within the trapway during a flush cycle but does not effect a siphon if the threshold concentration of bulk waste material is not reached in the trapway during the flush cycle, and wherein the trapway has a blow out region having an increased sectional area compared to the up leg, the blow out region is located between the up leg and the down leg, and the increased sectional area is orthogonal to a portion of a wall of the trapway defining the blow out region.

US Pat. No. 10,246,863

DRAIN VALVE FOR LOW-LEVEL WATER TANK FLUSHING

XIAMEN AXENT CORPORATION ...

1. A drain valve for low-level water tank flushing, comprising a drain valve body, a low-level washing ring flushing device and a switch assembly, wherein,the drain valve body comprises a sealing assembly and a valve seat, the sealing assembly is arranged on the valve seat and configured to open or close a drain port of the valve seat;
the low-level washing ring flushing device comprises a water inlet and a water outlet, the water inlet is in communication with an outlet of a water inlet valve in a water tank;
the switch assembly comprises a switch member and a switch sheet, and the switch member controls the movement of the sealing assembly and opens or closes the drain port by controlling the movement of the sealing assembly, and the switch sheet is configured to switch between different communication states of the water inlet and the water outlet;
wherein the switch member is connected to the switch sheet by a connection member, and in the case that the switch member opens the sealing assembly under the action of an external force, the switch sheet is moved to allow a channel between the water inlet and the water outlet to switch from a small opening state to a large opening state.

US Pat. No. 10,246,862

FOG DISPOSAL ARTICLE

1. An article for disposing of fat, oil, and/or grease (FOG), the article comprising:a top opening defined by a perimeter rim, the perimeter rim configured for placement on at least a portion of a bottom surface of a sink surrounding a drain cavity having a first maximum width;
a body permanently attached to the perimeter rim and at least partially located below the perimeter rim and the top opening, an exterior of the body defined by a continuous FOG-impermeable membrane, at least a portion of which is concave and sized to fit within the drain cavity, which portion has a second maximum width less than the first maximum width of the drain cavity, and an interior of the body comprising absorbent material for absorbing the FOG.

US Pat. No. 10,246,860

SHOWER CLAMP STRUCTURE

1. A shower clamp structure, comprising a water intake hose, an adaptor, a connecting hose and a shower head with a handle, and the adaptor being installed at an end of the water intake hose, and a water outlet formed at a predetermined position of an external periphery of the adaptor and provided for installing an end of the connecting hose, and an free end of the connecting hose being coupled to the handle of the shower head, characterized in that the adaptor has a clamping structure disposed at an end without the water intake hose for clamping the shower head, and the clamping structure comprises a spiral spring, a gear with a pillar, two clamping members, a cover, and a screw locking member; the adaptor has a recession formed at an end of the adaptor for receiving the spiral spring, and an end of the spiral spring is fixed in the recession, and the protrusion of the gear is installed in the spiral spring, and the external periphery of the protrusion is provided for positioning the free end of the spiral spring free end, and the two clamping members have a protective plate each, and both opposite sides of the two protective plates have a plate each, and each plate has a rack facing a side of the gear, and each rack is engaged with the gear, and the cover has a guide slot formed on a side of the cover and facing the adaptor and provided for receiving the plates of the two clamping members, and the screw locking member is passed through the cover, the gear, and the spiral spring and screwed into the adaptor.

US Pat. No. 10,246,858

MONITORING APPARATUS FOR A SANITARY INSTALLATION

Aquis Systems AG, Rebste...

1. A monitoring apparatus for a sanitary installation, the sanitary installation including at least a sanitary fitting having a water pipe with a discharge opening, a valve provided in the water pipe to turn water flow on and off to the water pipe, a controller adapted to control operation of the valve, an upper spatial region defined proximate to and below the discharge opening, and a lower spatial region defined proximate to and below the first spatial region, comprising a first sensor for monitoring the presence of a person in a first spatial region in the surroundings of the sanitary installation and a second sensor for monitoring a second spatial region in the surroundings of the sanitary installation, wherein the first sensor comprises an operating mode and a standby mode and the second sensor is embodied to switch the first sensor from the standby mode into the operating mode in the case of a predetermined detection, and a third sensor for detecting the person's hands in one of the upper spatial region or the lower spatial region, wherein the third sensor is adapted to send a signal, via the controller to the valve, to turn on water flow to the water pipe at a first water pressure when the third sensor detects the person's hands in the upper spatial region, and at a second water pressure greater than the first water pressure when the third sensor detects the person's hands in the lower spatial region.

US Pat. No. 10,246,857

DISTRIBUTING, OPENING AND CLOSING DEVICE FOR TAPS

GRIFERIAS GROBER, S.L., ...

1. Distributing, opening and closing device for taps, characterised in that said device comprises an inlet chamber (2), a shower hose (9), a shower column/head (8), a first outlet chamber (3) to the shower column/head (8) or to the shower hose (9), a second outlet chamber (4) to the shower hose (9) or to the shower column/head (8), a discharge opening (5) located within said device and a water regulator (6) located within said device which incorporates the functions of opening, intermediate closing and closing/discharging the shower hose (9) or the shower column/head (8) in one single mechanism, said water regulator (6) being connected to the inlet or outlet chambers (2,3 and 4) of the distributing device, and being regulated via an actuating control (7-7.1) with several positions, depending on the actuating rotation, to divert the water to the corresponding outlet chamber (3-4) or discharge opening (5) of both, wherein the water regulator (6) comprises an inlet pipe (2.1), an outlet pipe (3.1) to the shower column/head or shower hose, an outlet pipe (4.1) to the shower hose or shower column/head, a discharge pipe (5.1) and ceramic discs (10) and wherein the ceramic discs (10) comprises a fixed part (10.1) and a rotating part (10.2), the fixed part (10.1) being configured by several straight through-openings configured around the external diameter of the same, positioning, in the top semicircle, an opening (12) intended for discharging and on either side, an elongated opening (13), one intended for the outlet of the flexible hose (9) and the other for the shower column/head (8), positioning in the bottom semicircle an elongated opening (14) of larger dimensions, taking up a large part of the semicircular surface, intended for the inlet of water.

US Pat. No. 10,246,856

FIXING DEVICE FOR FIXING A WEAR OR PROTECTION ELEMENT ON A BUCKET OF AN EARTH MOVING MACHINE AND CORRESPONDING FIXING METHOD AND WEAR OR PROTECTION SYSTEM

1. A fixing device for fixing a wear or protection element on a bucket of an earth moving machine, comprising:a base, where said base comprises a housing with a front wall and a rear wall, and where said rear wall has an access extending from said housing and defining a longitudinal axis,
a stop, with a lower part suitable for being housed in said housing,
a screw, with a first end provided with a head and a second end, and
elastic means,
the lower part of said stop being housed in said housing and said screw going through said access in a mounted position and one of said first end or second end being fixed on said stop, such that the other one of said first end or second end is located on the side of access opposite housing, and said elastic means are arranged between
[a] said head and said access, when said second end is fixed on said stop, or
[b] a nut arranged on said second end and said access, when said first end is fixed on said stop,
and said elastic means are partially compressed, said elastic means having a length of value L0 in the direction of said longitudinal axis when they are fully compressed,
said stop having a front face opposite said front wall and a rear face opposite said rear wall in said mounted position, an elastic force of said elastic means pushing said rear face towards said rear wall, and the distance between said front face and said front wall in the longitudinal direction having a value D1, the distance in the longitudinal direction, in said mounted position, between
[a] said head and said access, when said second end is fixed on said stop, or
[b] said nut arranged on said second end an said access, when said first end is fixed on said stop,
having a value D2,
and where D2?L0>D1 in said mounted position.

US Pat. No. 10,246,853

MOBILE APPARATUS WITH OPERATING SYSTEM

1. Mobile apparatus comprising:a main frame provided with displacing means; and
a sub-frame connected rotatably to the main frame and an operating arm connected to the sub-frame, wherein the sub-frame is provided with a seating or standing location for a driver, operating instruments controllable by a driver, and a bus system connected to the operating instruments;
wherein the main frame is provided with a lifting device to which an implement is connected, wherein the lifting device comprises a lifting arm, and wherein the implement is coupled to the lifting arm;
wherein the mobile apparatus further comprises at least one drive configured for driving independently moving the lifting arm upward and downward with respect to the main frame and for operating the implement, and a control unit connected to the bus system for controlling said at least one drive on the basis of signals from the bus system such that the lifting device and the implement are independently controllable via the bus system using the operating instruments in the sub-frame such that a driver can control independently a first energy flow for moving the lifting arm upward and downward with respect to the main frame and a second energy flow for operating the implement connected to the lifting device, and
wherein said at least one drive comprises at least one energy source and at least one motor.

US Pat. No. 10,246,851

HYDROVAC

1. A hydrovac having a chassis, a mud tank and water tank forming a mud tank and water tank assembly mounted on the chassis, a hydraulic lift assembly capable of raising the mud tank and water tank assembly through a dump angle, the mud tank having a floor and a rear, the floor of the mud tank deepening forwardly, the water tank being located under the mud tank, and a hatch for the mud tank being located at the rear of the mud tank.

US Pat. No. 10,246,847

CLEANING DEVICE FOR CLEANING AN UNDERWATER GROUND-WORKING APPARATUS AND METHOD

BAUER Spezialtiefbau GmbH...

1. A cleaning device for cleaning an underwater ground-working apparatus, the cleaning device comprising:an enclosing body which extends substantially from a bottom of a body of water to above a water surface and encloses an inner space, wherein the inner space is configured so that a trench cutter or a drilling unit is movable within the inner space, and
a separating device, through which in the enclosing body an upper portion of the inner space is configured to be separated off to form a cleaning area, wherein the cleaning area is configured so that the trench cutter or the drilling unit is receivable within the cleaning area, and wherein the cleaning area is configured so that dirt is removable from the trench cutter or the drilling unit,
wherein the enclosing body has a telescopic portion, with which a length of the enclosing body is configured to be changed, and
wherein the separating device has at least one pivotably mounted separating flap, which is configured to be pivoted between a side open position and a separating position, in which the at least one pivotably mounted separating flap blocks off an upper cleaning area from a lower inner space of the enclosing body.

US Pat. No. 10,246,846

INTERCONNECTABLE HOLLOW STEEL PIPE FOR CONSTRUCTING FORCE DRIVEN PILES AND THE METHOD OF FORMING THE PILE

Brooke DeSantis, Montrea...

1. An interconnectable hollow metal pipe for the construction of force driven piles, said hollow metal pipe being comprised by: an elongated hollow metal pipe of predetermined length having a pipe connector, said pipe connector having a fitment section for connection in one of opposed hollow transverse ends of said hollow metal pipe for securing said pipe connector in said one of said hollow opposed transverse ends, the other of said opposed hollow transverse ends being a hollow transverse end, said pipe connector having a protruding pipe connecting section dimensioned for sliding fit in said other hollow transverse end of another of said hollow metal pipe, said pipe connector also having a flat transverse metal connector disc secured intermediate said fitment section and said protruding pipe connection section, said connector disc having an outer circumferential edge shaped for flush fit with an outer surface of said hollow metal pipe, and at least two spaced-apart weld cavities formed in said outer circumferential edge adjacent said outer surface of said elongated hollow metal pipe, said weld cavities each configured to have formed therein a weld not exceeding said outer surface of said hollow metal pipe to interconnect said weld cavities and said connector disc with a transverse end wall of said hollow metal pipe to provide an unobstructed pile outer surface comprised of two or more of said hollow metal pipes interconnected end-to-end by at least one of said pipe connectors.

US Pat. No. 10,246,845

PILE REPAIR APPARATUS

4D Tech Solutions, Inc., ...

1. A pile repair apparatus, comprising:a clamp for securing the pile repair apparatus to a pile to be repaired;
a friction member positioned along an inner surface of the clamp;
a platform connected to and extending across a top surface of the clamp; and
a flotation member secured to a top surface of the platform, wherein the flotation member is compressible.

US Pat. No. 10,246,842

WATER BARRIER, IN PARTICULAR A DIKE

DESSO SPORTS B.V., PA Wa...

1. A water barrier, comprising an inner slope, a crown and an outer slope, wherein the outer slope is located on the waterside, characterized in that a natural vegetation of at least one of the elements of inner slope, crown and outer slope is provided with fibers inserted into said vegetation,characterized in that said fibers are arranged in mutually adjacent rows, wherein the distance between the rows lies in the range of 10-50 mm, and wherein the mutual distance between fibers in a row amounts to 10-50 mm,
characterized in that the mutually adjacent rows are offset from each other so that the fibers are placed at the corner points of an imaginary equilateral triangle with sides of 10-50 mm.

US Pat. No. 10,246,841

SYSTEM FOR AERATION AND SEPERATION OF CONTAMINANTS FROM FLOWING WATER

1. A system for aeration and separation of contaminants from flowing water that provides clean water and reduces contamination in a channel of flowing water, said system comprising:a. a wall (1) partially embedded in the channel of flowing water;
b. a mesh (4) placed above said wall (1);
d. a plurality of baffles (3, 5) partially embedded in said channel and placed opposite to each other in such manner so as to increase the distance travelled by said water;
f. plants or algae planted around and on said baffles (3, 5);
h. a flooring (6) sloping towards flowing water direction;
i. a sink (2) constructed at a depth lower than said flooring (6); and
j. a water wheel (11) placed in flowing water.

US Pat. No. 10,246,840

ONE-PIECE BASE ASSEMBLY

Traffic Management Produc...

1. A self-righting and self-fronting base assembly for supporting an item of street furniture or a barrier, the base assembly comprising a base mounting portion and an elongate street furniture receiving portion projecting from the base mounting portion, wherein the base assembly is formed as a monolithic component from a polyurethane polymer, and the base mounting portion comprises one or more fixing elements, the base assembly further comprising an intermediate portion located between the street furniture receiving portion and the base mounting portion, wherein the intermediate portion has a minimum width which is greater than the corresponding width of the street furniture receiving portion, and the base mounting portion extends outwards from the intermediate portion.

US Pat. No. 10,246,833

ASPHALT PAVING MACHINE OPERATIONAL REPORTING SYSTEM

Roadtec, Inc., Chattanoo...

1. An asphalt paving machine comprising:(a) a drive system that is operated to move the paving machine across a surface to be paved;
(b) an asphalt receiving hopper which is adapted to receive asphalt paving material;
(c) a distributing auger;
(d) a hopper conveyor that is adapted to transport the asphalt paving material from the asphalt receiving hopper to the distributing auger, said hopper conveyor comprising:
(i) a hopper conveyor motor;
(ii) a speed sensor that is associated with the hopper conveyor motor and adapted to measure the rate of rotation of the hopper conveyor motor;
(e) a vertically-adjustable flow gate that is associated with the hopper conveyor and adapted to define the size of the gate opening from the asphalt receiving hopper to the distributing auger, said flow gate further comprising a flow gate position sensor that is adapted to determine the vertical position of the flow gate;
(f) a controller including a timer, said controller being:
(i) operatively connected to the drive system for moving the paving machine across the surface to be paved and adapted to receive a machine speed signal indicating the speed at which the paving machine is moving across the surface to be paved;
(ii) operatively connected to the speed sensor that is associated with the hopper conveyor motor and adapted to receive a conveyor speed signal indicating the speed of the hopper conveyor;
(iii) operatively connected to the flow gate position sensor and adapted to receive a flow gate signal indicating the vertical position of the flow gate;
(iv) adapted to use the machine speed signal, the conveyor speed signal and the flow gate signal to measure the amount of asphalt paving material delivered to the distributing auger per unit of time;
(g) a material sensor that is attached to the vertically-adjustable flow gate, said material sensor:
(i) being operatively connected to the controller and adapted to signal to the controller if asphalt paving material is passing under the flow gate;
(ii) having an arm that extends below the bottom of the flow gate, said arm being adapted to pivot upwardly when asphalt paving material is struck off by the flow gate;
(iii) having a switch that is configured to be actuated when the arm of the material sensor pivots upwardly in order to signal the controller that asphalt paving material is passing under the flow gate.

US Pat. No. 10,246,832

ROAD PAVER WITH WATER FOG SPRAY DEVICE

Caterpillar Paving Produc...

1. A road paver comprising:a screed assembly configured to lay a mat of paving material;
a tank configured to store a coolant,
a spray device configured to spray the coolant from the tank in proximity of the screed assembly of the road paver, and
a pump configured to receive the coolant from the tank and convey the coolant to the spray device,
wherein the coolant sprayed from the spray device includes a water fog.

US Pat. No. 10,246,831

SYNTHETIC ICE PANEL

1. A synthetic ice panel system for use on a ground surface, comprising:a plurality of substantially flat panels, each panel having a top surface, a bottom surface, and a peripheral edge having a plurality of interlocking tabs and recesses formed uniformly about an outer peripheral interlocking perimeter thereof, the plurality of interlocking tabs and recesses operative to mutually interlock with adjacent such panels, the bottom surface adapted for resting on the ground surface, each panel infused with a lubricant; and
an exercise attachment assembly having two side engagement members and an elongated foot stop member, the side engagement members each adapted to interlock with a recess or tab of one of the panels and support the elongated foot stop member above the panel, whereby a foot or ice skate is operable to be fixed between the panel and the foot stop to hold the foot/ice skate in place while a person performs exercises;
whereby when the plurality of panels are supported on the ground surface and mutually interlocked, the panels can be used as a rink for ice skating.

US Pat. No. 10,246,830

RAILROAD TRACK TOOL APPARATUS

1. A railroad track tool apparatus for clamping to a rail of a railroad track, the rail comprising an upper portion, an elongated central portion, and a lower portion, the railroad track tool apparatus comprising:a clamp assembly moveable between a clamped position and an unclamped position, the clamp assembly comprising:
a first bearing structure configured to engage an upper side of the upper portion of the rail; and
second and third bearing structures configured to engage an underside of the upper portion of the rail on opposite sides of the elongated central portion of the rail when the clamp assembly is in the clamped position, the clamp assembly moveable along the rail; and
a coupling connected with the clamp assembly and configured to couple the clamp assembly to a tool.

US Pat. No. 10,246,828

SANITARY TISSUE PRODUCTS

1. A sanitary tissue product roll comprising a multi-ply sanitary tissue product comprising a plurality of pulp fibers, wherein the multi-ply sanitary tissue product exhibits a Compressibility of greater than 34 mils/(log(g/in2)) as measured according to the Stack Compressibility Test Method, a Plate Stiffness of less than 3.75 N*mm as measured according to the Plate Stiffness Test Method, and a Slip Stick Coefficient of Friction of less than 500 (COF*10000) as measured according to the Slip Stick Coefficient of Friction Test Method.

US Pat. No. 10,246,826

METHOD FOR OPERATING A MACHINE FOR PRODUCING AND/OR PROCESSING A MATERIAL WEB

Siemens Aktiengesellschaf...

1. A method operating a machine for at least one of produce and processing a material web, the machine comprising at least one drive unit with a drive motor and a converter, the method comprising:supplying a first drive unit via an assigned converter with a current having a basic waveform continuous movement of the material web;
capturing a vibration propagating over the material web during the movement of the material web via a first drive unit;
measuring the vibration of the material web by a converter of the first drive unit and transforming the measured vibration into an electrical measurement signal;
evaluating the electrical measurement signal via an evaluation device to determine a presence of a signature which differs from the basic waveform of the current for the continuous movement of the material web; and
identifying that a web tear has occurs if the signature propagating over the material web is missing during the evaluation of the electrical measurement signal.

US Pat. No. 10,246,824

SHEET MANUFACTURING APPARATUS

Seiko Epson Corporation, ...

1. A sheet manufacturing apparatus comprising:a drum unit including a screen with numerous apertures through which airborne material including at least fiber passes, and a cylinder section without apertures, disposed to a rotating cylinder, the screen having an outer peripheral surface, the cylinder section having an outer peripheral surface, a first radial dimension from an axis of rotation of the drum unit to the outer peripheral surface of the cylinder section being equal to a second radial dimension from the axis of rotation of the drum unit to the outer peripheral surface of the screen;
a housing unit that has at least a pair of wall portions that oppose each other in a direction along the axis of rotation of the drum unit and that enclose the screen of the drum unit inside, at least the pair of the wall portions contacting the outer peripheral surface of the cylinder section;
a stationary flange unit that is disposed inside the cylinder section does not rotate, and overlaps with the cylinder section in a direction perpendicular to the axis of rotation of the drum unit; and
a fuser unit that applies heat and pressure to material that has passed through the apertures to form a sheet.

US Pat. No. 10,246,816

STEAM IRON WITH PRESSURIZED WATER RESERVOIR

KONINKLIJKE PHILIPS N.V.,...

1. A steam iron for treating garments, comprising:a heel to rest the steam iron on a supporting surface (S) when the steam iron is not treating garments;
a pressurisation unit having a chamber, the chamber comprising a water inlet for receiving water and a water outlet, the pressurisation unit comprising a mechanical energy storing element coupled to a pusher element for inducing the storage of mechanical energy in the mechanical energy storing element, the pressurization unit being adapted to:
a) in a rest position (P1) where the heel is placed on the supporting surface (S), generate an air vacuum in the chamber to draw water into the chamber via the water inlet due to the pusher element pushing against the mechanical energy storing element,
b) in a lifted position (P2) where the heel is not placed on the supporting surface (S), pressurise the water drawn in the chamber using energy stored in the mechanical energy storing element when in the rest position (P1);
a steam engine for generating steam from water towards the garments; and
a water output channel for carrying water under pressure from the water outlet to the steam engine.

US Pat. No. 10,246,815

STEAM IRON HEAD

KONINKLIJKE PHILIPS N.V.,...

1. A steam iron head, comprising:a soleplate panel including
an ironing plate through which steam is discharged from the steam iron head, and
a main body having a base wall and a cover on the soleplate panel, the base wall and cover being separated by outer side walls and inner side walls extending therebetween to define a steam pathway from a stream inlet through a non-cyclonic first steam flow section and a cyclonic second steam flow section to the ironing plate;
wherein the non-cyclonic first steam flow section defines an indirect, non-cyclonic, flow path between the steam inlet and the cyclonic second steam flow section, said indirect flow path being formed by said inner side walls that act as baffles to direct fluid through the non-cyclonic first steam flow section along a labyrinthine path around the baffles and in a direction that remains parallel to the base wall and the cover; and
wherein the cyclonic second steam flow section; defines a cyclonic flow path between the non-cyclonic first steam flow section and the ironing plate.

US Pat. No. 10,246,814

BUFFERING DEVICE IN AUTOMATIC CLOTH FEEDER

TOTOFOLDER MANUFACTURING ...

1. A buffering device in an automatic cloth feeder comprising:a cloth supply section that can supply a quantity of cloth exceeding a processing quantity of feeding so as to proceed with feeding in the automatic cloth feeder without congestion in the automatic cloth feeder performing a process in which the cloth is introduced to a feeding conveyor at a substantially central portion in a carrying direction, right and left trailing end portions of the cloth are crumpled from the right and left sides by guide members, the cloth is held in a deposition section, and the cloth is fed into the process,
wherein a cloth standby section in which the cloth to be carried stands by temporarily is set at a preceding stage of the feeding conveyor and at a following stage thereof; and
wherein a straightening unit is provided at the following stage of the feeding conveyor in order to cause the cloth held in the deposition section to be in a straightened state by pulling the cloth to the right and left sides, and the straightening unit is arranged at a plurality of places so as to be the cloth standby section.

US Pat. No. 10,246,813

METHOD FOR DRYING ARTICLES

Whirlpool Corporation, B...

1. A laundry drying applicator to dry an article, comprising:a support element;
a first anode element and a first cathode element;
a second anode element capacitively coupled with the first anode element and operably separated by at least a portion of the support element, and having a first base from which extends a first plurality of teeth; and a first plurality of tabs on at least some of the first plurality of teeth;
a second cathode element capacitively coupled with the first cathode element and operably separated by at least a portion of the support element and having a second base from which extends a second plurality of teeth and a second plurality of tabs on at least some of the second plurality of teeth wherein the first and second plurality of teeth are interdigitally arranged; and
a radio frequency (RF) generator coupled with the first anode element and the first cathode element and operable to energize the first anode element and the first cathode element;
wherein upon energization of the first anode element and the first cathode element by the RF generator, the capacitive coupling of the second anode element and the second cathode element generates a field of electromagnetic radiation (e-field) in the radio frequency spectrum, operable to dielectrically heat liquid within an article on the support element.

US Pat. No. 10,246,812

PORTABLE AND VERSATILE DRYING RACK

1. A portable and versatile drying rack comprising:a U-shaped bracket;
a first support arm;
a second support arm;
a drying rod;
a first locking hinge;
a second locking hinge;
the U-shaped bracket comprising a first leg, a second leg, and an interconnecting rod;
the first support arm and the second support arm being positioned parallel and offset to each other;
the first support arm being terminally mounted to the first leg through the first locking hinge;
the second support arm being terminally to the second leg through the second locking hinge;
the drying rod and the U-shaped bracket being positioned opposite to the each other, across the first support arm and the second support arm;
the drying rod being perpendicularly connected in between the first support arm and the second support arm;
the first locking hinge comprising a cylindrical body, a body-receiving cavity, a plurality of first semi-annular ramps, a plurality of second semi-annular ramps and an elastic coupler, the cylindrical body being positioned in between the first leg and the second leg, the cylindrical body being connected adjacent and perpendicular to the first leg, the body-receiving cavity laterally traversing into the first support arm opposite the second support arm, the plurality of first semi-annular ramps being radially distributed about the cylindrical body, each of the plurality of first semi-annular ramps being terminally connected to the cylindrical body opposite the first leg, the plurality of second semi-annular ramps being radially distributed about the body-receiving cavity, each of the plurality of second semi-annular ramps being connected to the first leg, the cylindrical body being slidably and rotatably mounted within the body-receiving cavity, the plurality of first semi-annular ramps being pressed against the plurality of second semi-annular ramps by the elastic coupler; and
the second locking hinge comprising a cylindrical body, a body-receiving cavity, a plurality of first semi-annular ramps, a plurality of second semi-annular ramps and an elastic coupler, the cylindrical body being positioned in between the first leg and the second leg, the cylindrical body being connected adjacent and perpendicular to the second leg, the body-receiving cavity laterally traversing into the second support arm opposite the first support arm, the plurality of first semi-annular ramps being radially distributed about the cylindrical body, each of the plurality of first semi-annular ramps being terminally connected to the cylindrical body opposite the second leg, the plurality of second semi-annular ramps being radially distributed about the body-receiving cavity, each of the plurality of second semi-annular ramps being connected to the second leg, the cylindrical body being slidably and rotatably mounted within the body-receiving cavity, and the plurality of first semi-annular ramps being pressed against the plurality of second semi-annular ramps by the elastic coupler.

US Pat. No. 10,246,811

WASHING MACHINE

SAMSUNG ELECTRONICS CO., ...

1. A washing machine comprising:a first cabinet having a first opening at an upper side of the first cabinet to receive laundry in a top-loading manner;
an outer door configured to open and close the first opening;
a first tub configured to contain water and having an opening corresponding to the first opening;
an inner door configured to open and close the opening of the first tub;
a first drum disposed in the first tub and configured to be rotatable on a first axis substantially perpendicular to the upper side of the first cabinet;
a reflector disposed on an inner circumference of the first opening such that an interior of the first drum is visible from an outside of the washing machine through the reflector;
a drive unit configured to supply driving power to the first drum to rotate the first drum;
a second cabinet disposed below the first cabinet and having a second opening at a front side of the second cabinet to receive laundry in a front-loading manner;
a second tub configured to contain water and having an opening corresponding to the second opening; and
a second drum disposed in the second tub and configured to be rotatable on a second axis substantially perpendicular to the first axis.

US Pat. No. 10,246,810

WASHING MACHINE APPLIANCE AND BACKSPLASH ASSEMBLY

HAIER US APPLIANCES SOLUT...

1. A washing machine defining a lateral direction, a transverse direction, and a vertical direction that are mutually orthogonal, the washing machine comprising:a cabinet defining an opening and including a backsplash bracket having a predefined footprint, the backsplash bracket including a first support deck and a second support deck, the first support deck having a planar top surface defining a rear portion of the opening, the second support deck also having a planar top surface, the planar top surface of the second support deck positioned beneath the planar top surface of the first support deck along the vertical direction;
a basket mounted within the cabinet, the basket defining a wash chamber beneath the opening to receive one or more clothing articles to be washed; and
a backsplash positioned over the predefined footprint, the backsplash including a first engagement hook disposed on the first support deck and a second engagement hook disposed on the second support deck such that the first and second engagement hooks mount the backsplash to the backsplash bracket,
wherein the second support deck includes a left support portion and a right support portion, and wherein the first support deck extends in the lateral direction from the left support portion to the right support portion such that the first support deck separates the left support portion from the right support portion along the lateral direction.

US Pat. No. 10,246,809

WASHING MACHINE AND METHOD OF CONTROLLING THE SAME USING AN AC MOTOR

Samsung Electronics Co., ...

1. A washing machine comprising:an alternating current (AC) motor configured to generate torque;
a clutch assembly configured to selectively transfer the torque to a rotating tub and a pulsator;
a speed detector configured to detect a rotary speed of the clutch assembly; and
a controller configured to repetitively perform operating and stopping the operation of the AC motor based on a predetermined target speed and the rotary speed of the clutch assembly during a spin-drying operation,
wherein the controller is configured to gradually increase the torque of the AC motor while operating the AC motor during the spin-drying operation.

US Pat. No. 10,246,808

LAUNDRY TREATING MACHINE WITH HIGH FREQUENCY DRYING APPARATUS

LG ELECTRONICS INC., Seo...

1. A laundry treatment machine comprising:a main body comprising a drum rotatably disposed therein;
a pedestal supporting the main body and providing a certain drying space that receives a drying subject;
a high frequency drying apparatus comprising an anode to which a high frequency is applied and a cathode electrically insulated from the anode to form an oscillation electric field between the anode and the cathode inside the drying space, and
a variable impedance configured to control an intensity of the oscillation electric field formed between the anode and the cathode, the variable impedance provided adjacent to the pedestal such that heat generated upon application of an electric current is transmitted into the pedestal,
wherein the pedestal comprises:
a storage having an open upper surface such that the drying subject is received into the storage through the open upper surface; and
a housing configured to receive the storage therein in a withdrawable manner, wherein the anode is formed on a surface of the housing arranged over the upper surface of the storage and facing a bottom surface of the storage, wherein the storage serves as the cathode, and wherein the variable impedance is provided over a bottom of the main body and heat generated from the impedance is transmitted to the storage by conduction through the housing.

US Pat. No. 10,246,807

COMPOSITE WARM-KEEPING TEXTILE STRUCTURE AND METHOD FOR MANUFACTURING THE SAME

1. A method for manufacturing a composite warm-keeping textile structure, comprising the steps of:(a) applying an elastic gripper-puffing mechanism to perform a plurality of puffing operations upon a plurality of opened cotton fibers in a puffing work area so as to form at least one puffy fiber agglomerate;
(b) applying the elastic gripper-puffing mechanism to grab a plurality of unit fiber agglomerates from the puffy fiber agglomerate and further to drop the plurality of unit fiber agglomerates onto a first cloth layer prepared on an operational platform;
(c) vibrating the operational platform so as to have the plurality of unit fiber agglomerates to be evenly distributed over the first cloth layer, so that the plurality of unit fiber agglomerates is formed as a fiber agglomerate distribution layer adhered onto the first cloth layer; and
(d) having a second cloth layer to cover and be adhered to the fiber agglomerate distribution layer, so that the first cloth layer and the second cloth layer clamps together the fiber agglomerate distribution layer in between to forming a composite warm-keeping textile structure.

US Pat. No. 10,246,805

CONNECTOR ASSEMBLY FOR USE IN FILTER ELEMENTS OF PRESS FILTER AND PRESS FILTER COMPRISING THE SAME

FAIRTECH INVESTMENT LIMIT...

1. A connector assembly for fastening filter elements onto a supporting plate of a press filter, the connector assembly comprising:a first cylindrical core;
a first flange extending outward circumferentially and vertically from one end of the first cylindrical core, the first flange being in connection with a respective filter element;
a second cylindrical core; and
a second flange extending outward circumferentially and vertically from one end of the second cylindrical core, the second flange being in connection with the respective filter element;
wherein the first cylindrical core is shaped and dimensioned such that the first cylindrical core passes through and is meshed with a central through hole of the supporting plate, and the second cylindrical core is shaped and dimensioned such that the second cylindrical core passes through and is meshed with the first cylindrical core, and wherein the first cylindrical core has a diameter smaller than a diameter of the central through hole of the supporting plate; and
wherein both the first cylindrical core and the first flange and both the second cylindrical core and the second flange are respectively molded as one piece from a stand-alone non-woven needle-punch fabric having a gram weight ranging from 250 g/m2 to 3000 g/m2, which is self-sustaining and has shape maintenance, and is moldable, said non-woven needle-punch fabric is configured to be molded into a desired shape, and persistently retaining said desired shape under an external pressure after the non-woven needle-punch fabric is molded, such that the connector assembly molded from the non-woven needle-punch fabric maintains its shape without any support;
wherein said stand-alone non-woven needle-punch fabric is made of at least first and second fibers, the melting point of said first fiber being less than that of said second fiber, wherein the first fiber is rendered to become molten, wherein the nonwoven fabric consists of a single layer of fiber formed by evenly blending the first fiber and the second fiber, wherein said first fiber has a melting point ranging from 115° C. to 130° C., and said second fiber has a melting point ranging from 180° C. to 230° C.

US Pat. No. 10,246,804

BRAIDING MACHINE

FUSE LONDON LTD, London ...

1. A braiding machine, comprising:a set of strand shuttles, each of the set of the strand shuttles having a strand holder positioned for holding a strand of flexible material and for dispensing the strand of flexible material under tension;
a strand retractor positioned to releasably securely receive and retract the strands from the strand shuttles;
a plurality of shuttle stations at which the strand shuttles can be parked, the plurality of shuttle stations being arranged in a circuit;
a carousel that is rotatable relative to the plurality of the shuttle stations;
a drive arrangement coupled to the carousel to drive the carousel to rotate in a first direction; and
at least one shuttle carriage rotatably mounted on the carousel and being driven by the rotation of the carousel in the first direction to rotate in a second direction opposite the first direction, the at least one shuttle carriage, when driven, repeatedly selecting an immediately previously unselected at least one of the set of the strand shuttles and moving the immediately previously unselected at least one of the set of the strand shuttles from an associated at least one of the plurality of the shuttle stations to another at least one of the plurality of the shuttle stations along the circuit so as to braid the strands of flexible material.

US Pat. No. 10,246,803

KNITTED WIRE CARRIER FOR WEATHER SEAL INSERT SUPPORT WITH LOCKSTITCHED REINFORCING WIRE

Hope Global, Division of ...

1. A knitted wire carrier for use in a weather seal comprising:a wire weft formed in a serpentine pattern and defining a width between alternating edge bends perpendicular to an elongated length;
a plurality of knitted warp yarns extending in the direction of the elongated length and located at positions along the width of the wire weft; and
at least a first compression and expansion-resisting wire knitted as a lockstitch to at least one of the warp yarns.

US Pat. No. 10,246,798

METHOD OF MAKING FIBER WITH GRADIENT PROPERTIES

The Boeing Company, Chic...

1. A method of making a fiber having improved resistance to microfracture formation at a fiber-matrix interface, the method comprising:mixing a plurality of nanostructures and one or more first polymers in a first solvent to form an inner-volume portion mixture;
mixing one or more second polymers in a second solvent to form an outer-volume portion mixture;
spinning the inner-volume portion mixture and the outer-volume portion mixture to form a precursor fiber;
heating the precursor fiber to oxidize the precursor fiber and to change a molecular-bond structure of the precursor fiber; and
obtaining the fiber comprising an inner-volume portion with a first outer diameter, the nanostructures, and with the one or more first polymers being oriented in a direction parallel to a longitudinal axis of the fiber, the fiber further comprising an outer-volume portion with a second outer diameter and the one or more second polymers, the outer-volume portion being in contact with and completely encompassing the inner-volume portion,
wherein the inner-volume portion has at least one of a tensile modulus and a strength that are higher than at least one of a tensile modulus and a strength of the outer-volume portion, resulting in the fiber having improved resistance to microfracture formation at the fiber-matrix interface.

US Pat. No. 10,246,797

METHOD FOR MANUFACTURING SILICON CARBIDE SINGLE CRYSTAL

SUMITOMO ELECTRIC INDUSTR...

1. A method for manufacturing a silicon carbide single crystal, the method comprising:packing a silicon carbide source material into a crucible, the silicon carbide source material having a Carr's flowability index of not less than 70 and not more than 100; and
sublimating the silicon carbide source material by heating the silicon carbide source material.

US Pat. No. 10,246,796

RAMO4 SUBSTRATE

Panasonic Intellectual Pr...

1. A RAMO4 substrate comprising a RAMO4 base material part containing a single crystal represented by the general formula RAMO4, where R represents one or a plurality of trivalent elements selected from a group of elements including: Sc, In, Y, and a lanthanoid element, A represents one or a plurality of trivalent elements selected from a group of elements including: Fe(III), Ga, and Al, and M represents one or a plurality of divalent elements selected from a group of elements including: Mg, Mn, Fe(II), Co, Cu, Zn, and Cd, wherein:the RAMO4 base material part has a beveled portion at an edge portion of the RAMO4 base material part,
the RAMO4 base material part has a principal surface having an off angle ? with respect to a cleavage surface of the single crystal,
the beveled portion contains a first region having an angle ?1 with respect to the principal surface, and a second region formed outside the first region, having an angle ?2 with respect to the principal surface, and
the angles ?, ?1, and ?2 satisfy the relationship ?1

US Pat. No. 10,246,794

DIAMOND SUBSTRATE AND METHOD FOR MANUFACTURING DIAMOND SUBSTRATE

ADAMANT NAMIKI PRECISION ...

1. A method of manufacturing a diamond substrate, comprising:preparing a base substrate;
forming a diamond layer formed from diamond single crystals on one side of the base substrate;
removing a part of the diamond layer to leave a plurality of pillar-shaped diamonds from the diamond layer, the plurality of pillar-shaped diamonds being spaced apart to each other;
causing the diamond single crystals to grow from tips of each pillar-shaped diamond while a space between the plurality of pillar-shaped diamonds are not fully filled and coalescing each of the diamond single crystals grown from the tips of each pillar-shaped diamonds to form a diamond substrate layer;
separating the diamond substrate layer from the base substrate; and
manufacturing the diamond substrate from the diamond substrate layer,
wherein a curvature of a crystal plane in an interior of the diamond substrate is set to higher than 0 km?1 and equal to or lower than 1500 km?1.

US Pat. No. 10,246,793

SEMICONDUCTOR MANUFACTURING METHOD AND SIC SUBSTRATE

FUJI ELECTRIC CO., LTD., ...

7. An SiC substrate, comprising:a front surface on which an epitaxial film is deposited; and
textures formed on the front surface, each texture being arranged along a direction perpendicular to a direction of the SiC substrate and having a first inclination surface that has an inclination angle ? to a front surface of the SiC substrate, wherein an angle between a basal plane of the SiC substrate and the first inclination surface of the formed texture is smaller than an off angle ?, and the angle |???| between the basal plane and said each texture is 3° or less.

US Pat. No. 10,246,789

SYSTEMS AND METHODS FOR COPPER RECOVERY VIA ROASTING AND LEACHING

FREEPORT MINERALS CORPORA...

1. A process comprising:roasting a metal bearing material comprising a copper carbonate under oxidizing conditions, at a temperature between about 625° C. and about 675° C.;
roasting the metal bearing material under reducing conditions, at a temperature of about 500° C. or greater; and
leaching the metal bearing material in a basic medium to yield a pregnant leach solution.

US Pat. No. 10,246,785

USE OF FLUIDIZED-BED ELECTRODE REACTORS FOR ALANE PRODUCTION

Ardica Technologies, Inc....

1. A reactor, comprising:an aluminum anode, a cathode, and an electrolyte that comprises at least one alkali metal aluminum hydride dissolved in a solvent, the alkali metal aluminum hydride comprising at least one of sodium aluminum hydride and lithium aluminum hydride;
a generator for inducing an electric potential difference between the aluminum anode and the cathode to convert at least a portion of the electrolyte into an alane adduct;
a reactor housing; and
a diaphragm disposed between the aluminum anode and the cathode, the diaphragm dividing the reactor housing into an anode chamber comprising aluminum particles and a cathode chamber.

US Pat. No. 10,246,783

COPPER ETCHANT SOLUTION ADDITIVES AND METHOD FOR PRODUCING COPPER ETCHANT SOLUTION

Shenzhen China Star Optoe...

1. A method for producing copper etchant solution, the production method comprising:producing copper etchant solution additives, wherein the copper etchant solution additives is an inorganic solution with cupric ions (Cu2+), and deionized water is a solvent for the copper etchant solution additives and is electric neutrality;
adding the copper etchant solution additives in copper etchant solution to obtain the copper etchant solution with a cupric ions (Cu2+) concentration of 700-1000 ppm before wet-etching, wherein the cupric ions (Cu2+) in the copper etchant solution are all electrolytic without forming complexes or depositions.

US Pat. No. 10,246,782

METHODS FOR ETCHING A WORKPIECE, AN APPARATUS CONFIGURED TO ETCH A WORKPIECE, AND A NON-TRANSITORY COMPUTER READABLE MEDIUM

INFINEON TECHNOLOGIES AG,...

1. An apparatus configured to etch a workpiece, the apparatus comprising:an etchant dispenser configured to dispense an etchant at a plurality of positions;
an etch profile determining circuit configured to determine a plurality of reference etch profiles, each reference etch profile corresponding to a respective position of the plurality of positions based on the etchant effects continuously across a reference workpiece corresponding to the etchant dispensed at the respective position;
a thickness determining circuit configured to determine a thickness profile of the workpiece, the thickness profile indicates the thicknesses of the workpiece continuously across the workpiece; and
an etch duration determining circuit configured to determine a respective etch duration for each position of the plurality of positions of the etchant dispenser based on the determined thickness profile and the plurality of reference etch profiles, to reduce a total thickness variation of the workpiece, each etch duration corresponding to a respective position of the plurality of positions.

US Pat. No. 10,246,781

METHOD FOR REMOVING A METAL DEPOSIT PLACED ON A SURFACE IN A CHAMBER

1. A method for removing a copper deposit disposed on a surface in an enclosure, said method comprising the following steps:a. a step of flowing oxidizing species capable of oxidizing the copper deposit; and
b. a step of flowing chemical species capable of volatilizing the oxidized copper deposit, said step b) being implemented during at least a part of said step a); and in step b), the chemical species are flowing according to a sequence of pulses;
wherein during a first pulse of the sequence of pulses the oxidation of said step a) becomes a minority reaction and the oxidized copper deposit is volatized by the chemical species flowing in said step b); and
wherein once said first pulse of the sequence of pulses has ended, the oxidation of the copper deposit is a dominant reaction until a next pulse of the sequence of pulses of said step b).

US Pat. No. 10,246,777

HEATER BLOCK HAVING CONTINUOUS CONCAVITY

ASM IP HOLDING B.V., Alm...

1. A heater block adapted to be installed in a plasma deposition or plasma etching apparatus comprising a showerhead and a reaction chamber, the heater block adapted to be arranged in the reaction chamber to support a substrate and comprising:at least one through-hole passing through the heater block, and
on its upper face, a plurality of surfaces separated from each other and defined by a continuous concavity, the continuous concavity comprising:
a plurality of first convexes at least partly defining a plurality of main concaves or depressions,
a concave channel connecting substantially every two adjacent main concaves or depressions,
a plurality of second convexes at least partly defining a concave or depression, at the center of the heater block, of a different shape or size from the plurality of main concaves or depressions,
wherein at least one first convex has a different shape from at least one second convex.

US Pat. No. 10,246,776

LAYER-FORMING DEVICE AND LAYER-FORMING METHOD

1. A layer-forming device that forms a thin layer in atomic layer unit using a layer-forming gas and a reactive gas, the layer forming device comprising:a layer-forming container;
a feeding mechanism configured to feed a substrate for layer-forming inside the layer-forming container;
a plasma-generating electrode disposed to face a feeding pathway of the substrate during feeding, the plasma-generating electrode configured to receive a supply of electric power to generate plasma using a reactive gas inside the layer-forming container;
a space-partitioning wall disposed between the feeding pathway of the substrate and the plasma-generating electrode, the space-partitioning wall forming a plasma-generating space between the plasma-generating electrode and the space-partitioning wall, the space-partitioning wall having a plurality of slit-shaped through holes for communicating the plasma-generating space and a space between the feeding pathway of the substrate and the space-partitioning wall, the through holes being disposed at intervals along a feeding direction of the substrate;
gas injectors, each of the gas injectors being disposed between the space-partitioning wall and the feeding pathway, and being sandwiched from both sides of a feeding direction by adjacent through holes of the plurality of through holes, each of the gas injectors including a layer-forming gas supply opening through which the layer-forming gas is supplied to the substrate and a pair of gas exhaust openings through which an excess gas including the supplied layer-forming gas above the substrate is sucked, the layer-forming gas supply opening being sandwiched between the pair of gas exhaust openings in the feeding direction, the layer-forming gas supply opening and the pair of the gas exhaust openings elongated in a lateral direction perpendicular to the feeding direction, having an identical length in the lateral direction respectively; and
a pair of inert gas supply openings through which inert gas is supplied, and the layer-forming gas supply opening and the pair of gas exhaust openings sandwiched between the pair of the inert gas supply openings in the feeding direction, and a member that blocks a portion of each of the inert gas supply openings provided on each of the inert gas supply openings along a lateral direction perpendicular to the feeding direction, the member dividing each of the inert gas supply openings into two sections.

US Pat. No. 10,246,775

FILM FORMING APPARATUS, METHOD OF FORMING FILM, AND STORAGE MEDIUM

TOKYO ELECTRON LIMITED, ...

1. An apparatus for forming a thin film on a substrate in a processing container under a vacuum atmosphere by performing a cycle a predetermined number of times, the cycle including alternately supplying a first gas and a second gas, which are process gases, onto the substrate, comprising:n first processing regions (n being an integer of 2 or more) which are spaced from each other along a circumferential direction of the processing container, and are used to process the substrate by supplying the first gas;
n second processing regions which are formed between the n first processing regions along the circumferential direction, and are used to process the substrate by supplying the second gas;
an isolation part which isolates the n first processing regions and the n second processing regions from each other;
a plurality of mounting parts which are disposed to be revolved along the circumferential direction and are used to mount substrates, respectively; and
a control part configured to intermittently revolve the plurality of mounting parts so that the substrates are alternately located in the n first processing regions and the n second processing regions in a state where a revolution is stopped,
wherein the plurality of mounting parts are disposed so that a first number of substrates located in the n first processing regions is the same as a second number of substrates located in the n second processing regions in a state where the revolution of the plurality of mounting parts is stopped.

US Pat. No. 10,246,771

FILM FORMING METHOD AND PLASMA CHEMICAL VAPOR DEPOSITION APPARATUS

TOYOTA JIDOSHA KABUSHIKI ...

1. A method of forming a diamond-like carbon film on a workpiece installed in a reactor of a plasma chemical vapor deposition (PCVD) apparatus, wherein the PCVD apparatus includes:(i) a microwave output device which outputs microwaves, and
(ii) a waveguide member which extends to an inside of the reactor from an outside of the reactor, wherein the waveguide member supports the workpiece with a portion of the waveguide member positioned in the reactor, and the waveguide member is configured to propagate the microwaves from the microwave output device to the workpiece,
the method comprising:
supplying a hydrocarbon gas into the reactor of the PCVD apparatus;
outputting microwaves having an intensity of higher than a first intensity and lower than a second intensity from the microwave output device, through the waveguide member and to the workpiece to decompose the hydrocarbon gas into a plasma and to form the diamond-like carbon film on the workpiece, wherein:
the first intensity and the second intensity are defined by a method comprising:
supplying the hydrocarbon gas into the reactor of the PCVD apparatus;
outputting microwaves having a third intensity starting from “0” intensity from the microwave output device, through the waveguide member and to the workpiece;
increasing the third intensity of microwaves outputted from the microwave output device;
defining the first intensity to be the third intensity when a first step-up of a bias current of the workpiece occurs;
further increasing the third intensity of microwaves outputted from the microwave output device;
defining the second intensity to be the third intensity when a second step-up of the bias current of the workpiece occurs;
wherein the first step-up and the second step-up of the bias current are each a sudden discontinuous increase in the bias current of the workpiece, and
wherein the hydrocarbon gas: (i) is acetylene or a hydrocarbon gas having two or more carbon atoms and two or more hydrogen atoms, and (ii) causes step-up of the bias current of the workpiece only twice.

US Pat. No. 10,246,769

THIN FILM DEPOSITION APPARATUS

Samsung Display Co., Ltd....

1. A method of manufacturing a thin film on a substrate, the method comprising:passing deposition material through a plurality of deposition source nozzles of a deposition source nozzle unit, the deposition source nozzles being arranged in one or two rows extending in a first direction, each of the one or two rows comprising more than three of the deposition source nozzles;
passing the deposition material from the deposition source nozzle unit through a plurality of patterning slits in a patterning slit sheet, the patterning slits being arranged in a row in a second direction that is perpendicular to the first direction, each of the patterning slits being extended in the first direction, an outermost one of the plurality of patterning slits along the second direction being spaced apart outwardly in the second direction from the deposition source nozzle unit, wherein the patterning slit sheet is connected to the deposition source nozzle unit such that the substrate is movable with respect to the deposition source nozzle unit and the patterning slit sheet; and
depositing the passed deposition material during a relative linear motion between the patterning slit sheet and the substrate to form the thin film,
wherein the deposition material from the deposition source nozzle unit is patterned on the substrate by the patterning slit sheet in pattern in which the deposition material is deposited at first regions on the substrate corresponding to the patterning slits and is not deposited at second regions on the substrate adjacent the first regions and corresponding to portions of the patterning slit sheet that do not have the patterning slits, each of the portions of the patterning slit sheet that do not have the pattern slits extending parallel to the first direction between a respective pair of adjacent patterning slits of the plurality of patterning slits,
wherein in a state in which the patterning slit sheet for patterning the deposition material on the substate is adjacent to the substrate and not coupled to the substrate, the depositing of the passed deposition material is performed while the substrate moves linearly in the first direction relative to a thin film deposition apparatus that is in a fixed state, the thin film deposition apparatus comprising the deposition source nozzle unit and the patterning slit sheet, and
wherein the depositing source nozzle unit and the patterning slit sheet are connected by a connection member arranged obliquely from the deposition source nozzle unit to the patterning slit sheet.

US Pat. No. 10,246,768

PROCESS FOR PREPARATION OF MICRON-SIZED SINGLE CURVED CRYSTALS OF METALS

1. A process for the preparation of micron-sized particles having a controlled curvature, said particles spread over a supporting substrate and including a single-crystal first metal wrapped in a nanoporous structure, said process comprising:(i) providing said substrate;
(ii) depositing vapours of the first metal and of a second metal on a surface of said substrate, thus forming a substrate deposited with either a thin film comprising said first and second metals, or two thin films each comprising a different metal of said first and second metals, wherein said metals deposited on said substrate are selected from Au, Ag, Ge, Cu, and Pt, and the atomic percentage ratio between said first metal and said second metal is such that upon annealing said film(s), said first metal and said second metal form a eutectic melt;
(iii) annealing said film(s) for a sufficient time period to form said eutectic melt that spontaneously dewets into micron-sized droplets spread over said substrate;
(iv) (a) cooling said eutectic melt to room temperature, or (b) continuing the annealing of step (iii) in an environment that contains oxygen, thereby removing the second metal from said eutectic melt, to consequently grow a single crystal of the first metal, wherein according to a phase diagram of the eutectic melt, in each one of said droplets, said single crystal is grown in the confined space of said droplet, has a controlled curvature determined by the curved shape of said confining droplet and is wrapped in a two-phase eutectic microstructure comprising the first metal and the second metal;
(v) cooling the grown single crystals of the first metal wrapped in the two-phase eutectic microstructure comprising the first metal and the second metal to obtain micron-sized particles of the single-crystal first metal wrapped in a solid phase comprising said two metals; and
(vi) removing the second metal from said solid phase, thereby obtaining the micron-sized particles of the single-crystal first metal wrapped in the nanoporous structure, said particles having a controlled curvature and being spread over the supporting substrate;
wherein said substrate is inert relative to said thin film(s) formed in step (ii); and the eutectic melt in step (iii) dewets within a temperature range allowing dewetting to occur prior to diffusion intermixing with said substrate and/or oxidation.

US Pat. No. 10,246,767

SLIDING ELEMENT, INTERNAL COMBUSTION ENGINE AND PROCESS FOR OBTAINING SLIDING ELEMENT

Mahle International GmbH,...

1. A sliding element for internal combustion engines, comprising a ferrous base provided with a film applied upon a sliding surface, the film having, sequentially, a metal connecting layer, a transitional layer, and a contact layer, wherein:the transitional layer includes a carbide containing a metal element;
the contact layer contains DLC (diamond-like carbon) doped with the metal element of the transitional layer, the DLC containing a maximum of 2% hydrogen by weight;
an atomic ratio between metal and carbon in the contact layer in terms of a ratio Me/C is equal to or less than 0.1; and
the connecting layer includes one of chromium, nickel or cobalt having a face centred cubic (fcc) structure.

US Pat. No. 10,246,762

ALUMINUM ALLOY ELECTRIC WIRE AND AUTOMOTIVE WIRE HARNESS USING THE SAME

YAZAKI CORPORATION, Mina...

1. An aluminum alloy electric wire comprising an aluminum alloy strand that comprises magnesium (Mg), silicon (Si) and a remainder comprising of aluminum (Al) and impurities,wherein the aluminum alloy strand comprises 0.60 to 1.4 by atomic percent of Mg and 0.2 to 1.0 by atomic percent of Si, has a coefficient of variation in a range of 0.6 to 0.8, the coefficient of variation being calculated by dividing a standard deviation of a grain size of crystal grains observed on a cross section of the aluminum alloy strand by an average grain size of the crystal grains, has tensile strength of 165 MPa or more, has elongation at break of 7 percent or more, and has conductivity of 40 percent IACS or more.

US Pat. No. 10,246,759

METHOD OF RECOVERING RARE-EARTH ELEMENTS

Nippon Light Metal Compan...

1. A method of recovering rare-earth elements from a bauxite residue, which is produced as a by-product in a Bayer process and is used as a raw material,the method comprising:
a leaching step of bringing the bauxite residue into contact with a liquid leaching agent to recover a leachate containing rare-earth elements;
a pretreatment step of bringing the leachate recovered in the leaching step into contact with a pretreatment liquid containing one of a phosphoric acid ester-based extractant and a phosphonic acid ester-based extractant at a concentration of from 0.01 to 0.1 mol/L, followed by filtration treatment, to thereby recover a pretreated leachate containing the rare-earth elements;
an extraction step of bringing the pretreated leachate into contact with an extraction treatment liquid containing a phosphoric acid ester-based extractant to recover an extract liquid containing the rare-earth elements; and
a back extraction step of bringing the extract liquid into contact with a back extraction treatment liquid to recover the rare-earth elements,
the leaching step comprising recovering a leachate having a pH of 0.5 to 1.2 by using an acidic liquid leaching agent,
the extraction step comprising adjusting the pH of the pretreated leachate to 1.0 to 1.7 and then bringing the pretreated leachate into contact with the extraction treatment liquid under a condition that the pretreated leachate has an oxidation-reduction potential of 300 mV or less adjusted by a method of performing electrolytic reduction treatment,
wherein the back extraction treatment liquid comprises a 40 to 60 mass % sulfuric acid aqueous solution, and wherein the extract liquid and the sulfuric acid aqueous solution are brought into contact with each other at a volume ratio of extract liquid:sulfuric acid aqueous solution of from 5:1 to 10:1, or
wherein the back extraction treatment liquid comprises a 4 N to 8 N hydrochloric acid aqueous solution, and wherein the extract liquid and the hydrochloric acid aqueous solution are brought into contact with each other at a volume ratio of extract liquid:hydrochloric acid aqueous solution of from 5:1 to 10:1.

US Pat. No. 10,246,745

DNA SEQUENCING DETECTION FIELD EFFECT TRANSISTOR

International Business Ma...

1. A method of DNA sequencing detection, said method comprising:providing a semiconductor structure comprising a doped epitaxial source semiconductor material structure located on a first portion of a semiconductor substrate and a doped epitaxial drain semiconductor material structure located on a second portion of said semiconductor substrate; a gate dielectric portion located on a third portion of said semiconductor substrate and positioned entirely between, and spaced apart from, a sidewall edge of said doped epitaxial source semiconductor material structure and a sidewall edge of said doped epitaxial drain semiconductor material structure; and a non-stick nucleotide, DNA and DNA polymerase material structure located atop said doped epitaxial source semiconductor material structure and atop said doped epitaxial drain semiconductor material structure, wherein a cavity is present in said non-stick nucleotide, DNA and DNA polymerase material structure that exposes a topmost surface of said gate dielectric portion;
forming a DNA polymerase on a portion of said topmost surface of said gate dielectric portion and within said cavity;
attaching a DNA template to a surface of said DNA polymerase, wherein said DNA template is present in a solution that further contains various nucleotides; and
measuring a change in threshold voltage caused by each nucleotide present in said solution by monitoring the change of drain current of said semiconductor structure.

US Pat. No. 10,246,743

METHODS FOR FORMING LIPID BILAYERS ON BIOCHIPS

GENIA TECHNOLOGIES, INC.,...

1. A method for forming a lipid bilayer for use in a nanopore sensing device, comprising:(a) providing a primed chip comprising a fluid flow path in fluid communication with a plurality of sensing electrodes;
(b) flowing a lipid solution into the fluid flow path; and
(c) flowing at least one bubble onto the fluid flow path, thereby forming a lipid bilayer adjacent to the sensing electrodes, wherein the bubble spans the plurality of sensing electrodes.

US Pat. No. 10,246,740

SELECTIVE AMPLIFICATION OF DESIRED NUCLEIC ACID REGIONS IN A TARGET SEQUENCE

1. A method for selective amplification of desired amplicons in a two-stage polymerase chain reaction, comprising the steps of:providing a target genetic material;
denaturing the target genetic material;
adding a set of target primers under conditions allowing annealing of primers to the target genetic material;
each primer in said set of target primers comprising
a target specific sequence,
a mismatch control sequence, and
a generic hybridization sequence;
said generic hybridization sequence being identical in each target primer;
said mismatch control sequence and generic hybridization sequence being in close proximity to each other; and
said set of target primers comprising at least two primer pairs adapted for amplification of at least two overlapping desired amplicons in the target genetic material, such that there is a possibility of obtaining at least one undesired amplicon in the region of overlap;
said set of target primers being further characterized in that any pair of primers that flank a desired amplicon sequence have non-matching mismatch control sequences, while any pair of primers that flank an undesired amplicon sequence have matching mismatch control sequences;
carrying out a first multiplex polymerase chain reaction resulting in overlapping amplicons corresponding to different possible pair-wise combinations of primers in the first set of primers, said overlapping amplicons being maintained under conditions such that they self-hybridize through base-pair coupling between the complementary sequences resulting from the generic hybridization sequence in each primer;
treating said overlapping amplicons under selection conditions that are such that desired amplicons denature because of non-complementary sequences resulting from the non-matching mismatch control sequences, while undesired amplicons stay self-hybridized because of additional complementary sequences resulting from the matching mismatch control sequences;
adding generic primers, each comprising a sequence which is complementary to the generic hybridization sequence;
carrying out a second polymerase chain reaction, resulting in the selective amplification of desired amplicons.

US Pat. No. 10,246,739

EXONUCLEASE CYCLING ASSAY

GEORGETOWN UNIVERSITY, W...

1. A method for detecting a target polynucleotide in a test sample, wherein the target polynucleotide has a target sequence and is protected against digestion by a 5? exonuclease, wherein the 5? exonuclease is lambda exonuclease, comprising(a) incubating the test sample with a probe having a sequence complementary with the target sequence and lacking a phosphorylated 5? end, wherein the probe has a quencher at its 5? end and a fluor, whereby a hybrid of the probe and the target polynucleotide is formed, wherein the hybrid comprises a hybridization region formed between the target sequence and the probe, wherein the fluor of the probe is quenched by the quencher before forming the hybrid, and wherein the fluor of the probe is quenched by the quencher in the hybrid;
(b) exposing the hybrid to the 5? exonuclease to digest the probe in the hybrid and forming a reaction mixture, whereby a digested probe comprising the fluor is generated, wherein the fluorescence of the fluor of the digested probe is not quenched;
(c) dissociating the target polynucleotide from the digested probe in the reaction mixture;
(d) repeating steps (a)-(c) by adding the probe and the 5? exonuclease to the reaction mixture after step (c), wherein step (b) of step (d) is performed for a first time period until no further increase in the fluorescence in the reaction mixture;
(e) determining a first fluorescence intensity of the fluor in the reaction mixture after step (d);
(f) repeating steps (a)-(d) with a control sample in place of the test sample, wherein step (b) in step (f) is performed for a second time period, wherein the second time period equals to the first time period, wherein the control sample is identical to the test sample except without the target polynucleotide; and
(g) determining a second fluorescence intensity of the fluor in the control sample after step (f), wherein the first fluorescence intensity greater than the second fluorescence intensity indicates the presence of the target polynucleotide in the test sample.

US Pat. No. 10,246,676

CELL STIMULATION APPARATUS

INDUSTRY-ACADEMIC COOPERA...

7. A cell stimulation apparatus, comprising:a cell containment part in which a plurality of cell containment grooves containing cells are formed;
a protrusion part that is formed, in a concave and convex shape, on inner circumferential surfaces of the plurality of cell containment grooves; and
a pressure control part that supports the cell containment part and controls intensity of mechanical stimulation applied to cells by applying pressure to the cell containment part,
wherein a bottom of the cell containment part is made of a flexible material,
wherein the pressure control part comprises:
a stage which supports the cell containment part and includes air holes through which air enters and exits;
a pump that applies vacuum pressure to the cell containment part in a vertical direction; and
a control part that controls driving of the pump,
wherein a plurality of air suction pipes are provided to the stage,
wherein the plurality of air suction pipes are disposed at positions corresponding to the plurality of cell containment grooves, and
wherein air suction pipes among the plurality of air suction pipes disposed in a same row or a same column of plurality of rows and columns formed b the plurality of cell containment grooves are independently controlled from the other air suction pipes of the plurality of air suction pipes.

US Pat. No. 10,246,663

LIPID COMPOSITION AND METHOD FOR PRODUCING SAME

IHI CORPORATION, Tokyo (...

1. A lipid composition, wherein the EPA to DHA mass ratio (EPA/DHA) in fatty acids constituting the lipid is (EPA/DHA)=1.2 to (EPA/DHA)=7.2, the proportion of phospholipid in the total lipid is no lower than 3% by mass and no higher than 54% by mass, the cadmium concentration is 0.4 mg or lower per kilogram of lipid, the arsenic concentration is 3 mg or lower per kilogram of lipid, and the concentration of dioxins is 2 pg-TEQ or lower per gram of lipid.

US Pat. No. 10,246,660

NATURAL-GAS PURIFICATION APPARATUS

MITSUBISHI HEAVY INDUSTRI...

1. A natural-gas purification apparatus for purifying natural gas from ground by separating carbon dioxide from the natural gas, comprising:a pressure adjuster that adjusts a pressure of the natural gas from the ground;
a natural-gas-liquid separator that liquefies and separates a part of natural-gas liquid by cooling the natural gas after the pressure adjustment by the pressure adjuster;
a heater that heats the natural gas after the separation of the part of the natural-gas liquid by the natural-gas-liquid separator;
a carbon-dioxide separator that separates carbon dioxide from the natural gas heated by the heater through a carbon-dioxide separation membrane; and
a controller that adjusts and controls at least one of a pressure of the natural gas to be achieved by the pressure adjuster, a temperature to which the natural gas is to be cooled by the natural-gas-liquid separator, and a temperature to which the natural gas is to be heated by the heater to a value which has been set in advance according to composition of the natural gas from the ground, such that the natural-gas-liquid separator liquefies and separates the part of the natural-gas liquid in the natural gas and the carbon-dioxide separator maintains a remaining part of the natural-gas liquid in the natural gas in gaseous form.

US Pat. No. 10,246,654

HIGH DENSITY RENEWABLE FUELS BASED ON BARBATENE AND THUJOPSENE

The United States of Amer...

1. A method for manufacturing turbine and diesel fuels, comprising:providing a sesquiterpene mixture consisting of barbatene, thujopsene, alpha-barbatene, beta-chamigrene, beta-acoradiene, cuparene, and combinations thereof, wherein the sesquiterpene mixture is generated by metabolically engineered organisms from substrates including glucose, sucrose, fructose, other reducing sugars, cellobiose, cellulose, hemicellulose, lignocellulose, lignin, methane, and CO2, or by isolating the sesquiterpene mixture from plant material by solvent extraction or steam distillation;
purifying said sesquiterpene mixture, thereby forming a purified sesquiterpene mixture;
isomerizing said purified sesquiterpene mixture with at least one heterogeneous or homogenous acid catalyst to produce isomers; and
hydrogenating said isomers with at least one hydrogenation catalyst under hydrogen pressure to generate hydrogenated isomers; and distilling said hydrogenated isomers to produce a first high density fuel and a higher molecular weight residue.

US Pat. No. 10,246,651

INTEGRATED SOLVENT DEASPHALTING, HYDROTREATING AND STEAM PYROLYSIS SYSTEM FOR DIRECT PROCESSING OF A CRUDE OIL

Saudi Arabian Oil Company...

1. An integrated solvent deasphalting, hydrotreating and steam pyrolysis system for the direct processing of a crude oil to produce olefinic and aromatic petrochemicals, the system comprising:a solvent deasphalting zone having a deasphalted and demetalized oil stream outlet and a bottom asphalt outlet;
a catalytic hydroprocessing zone in fluid communication with the deasphalted and demetalized oil stream outlet of the solvent deasphalting zone, the catalytic hydroprocessing zone having inlet for receiving a mixture of the deasphalted and demetalized oil stream and hydrogen recycled from a steam pyrolysis product stream effluent, and make-up hydrogen as necessary, and an outlet for discharging a hydroprocessed effluent, the catalytic hydroprocessing zone including a reactor operating under conditions effective to produce a hydroprocessed effluent;
a thermal cracking zone including
a thermal cracking convection section with an inlet in fluid communication with the hydroprocessing zone outlet, and an outlet,
a vapor-liquid separator having an inlet in fluid communication with the thermal cracking convection section outlet, a vapor fraction outlet and a liquid fraction outlet,
wherein the vapor liquid separator includes:
a pre-rotational element having an entry portion and a transition portion, the entry portion having an inlet for receiving a flowing fluid mixture from the thermal cracking convection section outlet, and a curvilinear conduit;
a controlled cyclonic section having
an inlet adjoined to the pre-rotational element through convergence of the curvilinear conduit and the cyclonic section,
a riser section at an upper end of the cyclonic member through a vapor fraction outlet through which vapors passes to a thermal cracking pyrolysis section;
and
a liquid collector/settling section through which liquid passes as a discharged liquid fraction,
and
the thermal cracking pyrolysis section having an inlet in fluid communication with the vapor fraction outlet of the vapor-liquid separator, and a pyrolysis section outlet;
a quenching zone in fluid communication with the pyrolysis section outlet, the quenching zone having an outlet for discharging an intermediate quenched mixed product stream and an outlet for discharging quenching solution;
a product separation zone in fluid communication with the intermediate quenched mixed product stream outlet, and the product separation zone having a hydrogen outlet, one or more olefin product outlets and one or more pyrolysis fuel oil outlets; and
a hydrogen purification zone in fluid communication with the product separation zone hydrogen outlet, the hydrogen purification zone having an outlet in fluid communication with the hydroprocessing zone.

US Pat. No. 10,246,645

METHODS FOR REDUCING FLUE GAS EMISSIONS FROM FLUID CATALYTIC CRACKING UNIT REGENERATORS

UOP LLC, Des Plaines, IL...

1. A method for reducing flue gas particulate emissions from a fluid catalytic cracking (FCC) unit regenerator comprising the steps of:combining biochar with a hydrocarbon feedstock to generate a biochar-containing feedstock, wherein said biochar is derived from rapid thermal processing of biomass;
contacting the biochar-containing feedstock with an FCC catalyst; and
regenerating said FCC catalyst to produce the flue gas.

US Pat. No. 10,246,640

MIXTURES OF AT LEAST ONE DIALKYLPHOSPHINIC ACID WITH AT LEAST ONE OTHER DIALKYLPHOSPHINIC ACID THAT IS DIFFERENT THEREFROM, METHOD FOR PRODUCTION THEREOF, AND USE THEREOF

Clariant International Lt...

1. A flame-retardant thermoset composition or, film, comprising 0.5 to 45% by weight of a mixture of at least one dialkylphosphinic acid of the formula (I)
wherein
R1, R2 are the same or different and are C1-C18-alkyl, C2-C18-alkenyl, C6-C18-aryl or C7-C18-alkylaryl,
with at least one different dialkylphosphinic acid of the formula (II)

wherein
R3, R4 are the same or different and are C1-C18-alkyl, C2-C18-alkenyl, C6-C18-aryl or C7-C18-alkylaryl,with the proviso that at least one of the R3 and R4 radicals is different than R1 and R2, 0.5 to 99.5% by weight of thermoset polymer, 0 to 55% by weight of additives and 0 to 55% by weight of filler or a reinforcing material, where the sum of the components is 100% by weight.

US Pat. No. 10,246,639

FIRE RETARDANT COMPOSITIONS AND CABLE SEPARATORS FORMED THEREOF

General Cable Technologie...

1. A fire retardant composition comprising:polyvinyl chloride;
about 10 parts to about 40 parts, by weight, of a plasticizer comprising one or more of a trimellitate ester and a phosphate ester;
about 0.1 part to about 25 parts, by weight, of a brominated fire retardant additive;
about 25 parts to about 75 parts, by weight, of a fire retardant synergist comprising a metal hydroxide;
about 1 part to about 10 parts, by weight, of a mixed metal stabilizer; and
wherein the fire retardant composition is substantially free of a halogenated plasticizer.

US Pat. No. 10,246,634

QUANTUM DOT HAVING POLYMERIC OUTER LAYER, PHOTOSENSITIVE COMPOSITIONS INCLUDING THE SAME, AND QUANTUM DOT POLYMER COMPOSITE PATTERN PRODUCED THEREFROM

SAMSUNG ELECTRONICS CO., ...

17. A quantum dot complex comprising:an organic ligand compound bonded to the surface of the quantum dot, and
a polymeric outer layer comprising a copolymer, which comprises;
a first repeating unit comprising a moiety capable of intermolecularly interacting with the organic ligand compound, the quantum dot surface, or a combination thereof, and
a second repeating unit comprising a reactive moiety selected from the group consisting of a C2 to C20 alkenyl group, a C2 to C20 alkynyl group, an epoxy group, a thiol group, an anhydride group represented by Chemical Formula 4, an imide group represented by Chemical Formula 5, a group represented by any of Chemical Formula 6 to Chemical Formula 12, and a combination thereof:

wherein, in the chemical formulae, R is H, a C1 to C10 alkyl group, or a C6 to C20 aryl group, and
* is a linking portion to an adjacent atom present in a backbone of the copolymer.

US Pat. No. 10,246,631

METHOD OF STIMULATING A SUBTERRANEAN FORMATION USING AN ACID PRECURSOR COMPOSITION

Halliburton Energy Servic...

1. A method of stimulating a subterranean formation, comprising:placing a fracturing composition in a subterranean formation;
hydraulically fracturing the subterranean formation with the fracturing composition to form at least one fracture and a spent fracturing composition;
flushing the subterranean formation;
placing an acid precursor composition in the subterranean formation, wherein the precursor composition comprises greater than 7 to about 99 wt. %, based on the total weight of the precursor composition, of an acid precursor;
forming an acid from the acid precursor; and
acidizing the subterranean formation in the fracture with the formed acid.

US Pat. No. 10,246,627

METHODS OF USING INVERT EMULSION FLUIDS WITH HIGH INTERNAL PHASE CONCENTRATION

M-I L.L.C., Houston, TX ...

1. A method of completing a wellbore penetrating a subterranean formation, the wellbore comprising a cased section and an uncased section, the method comprising:introducing invert emulsion fluid into the uncased section of the wellbore, the invert emulsion fluid comprising:
an oleaginous external phase;
a non-oleaginous internal phase, wherein a ratio of the oleaginous external phase and non-oleaginous internal phase is less than 50:50; and
an emulsifier stabilizing the oleaginous external phase and the non-oleaginous internal phase; and
running a liner, sand control screen assembly, swell packer assembly, or inflow control device to a selected depth within the uncased section of the wellbore in which the invert emulsion fluid is located;
wherein the emulsifier is an alkoxylated ether acid.

US Pat. No. 10,246,626

LOSS CIRCULATION COMPOSITIONS (LCM) HAVING PORTLAND CEMENT CLINKER

Saudi Arabian Oil Company...

1. A lost circulation material (LCM) composition, comprising:Portland cement clinker, wherein the Portland cement clinker consists of non-hydraulic, non-cementiceous unground Portland cement clinker particles;
cement;
a carrier fluid, wherein the carrier fluid comprises an aqueous carrier fluid that includes at least one of diutan gum, xanthan gum, and welan gum; and
an inorganic consolidation activator selected to consolidate the clinker in the composition to form a plug when introduced into a lost circulation zone.

US Pat. No. 10,246,621

HEAT TRANSFER METHODS, SYSTEMS AND COMPOSITIONS

HONEYWELL INTERNATIONAL I...

1. A refrigerant blend consisting of:about 50% by weight difluoromethane (HFC-32),
about 11.5% by weight pentafluoroethane (HFC-125), and
about 38.5% by weight trifluoroiodomethane (CF3I),
wherein the percentages are based on the total weight of the three compounds in the blend.

US Pat. No. 10,246,619

METHOD FOR INCREASING THE REACTIVITY OF LIGNIN

UPM-KYMMENE CORPORATION, ...

1. A method for producing a binder composition, the method comprising:(a) forming, under heating at a temperature of 30-70° C., an aqueous dispersion consisting of alkali, lignin, and water, wherein the alkali comprises a hydroxide of an alkali metal, and wherein the concentration of the lignin is 10-50 weight-% based on the total weight of the aqueous dispersion;
(b) heating the aqueous dispersion formed in step (a) at a temperature of 50-95° C., thereby producing alkalated lignin, wherein the alkalated lignin has an increased reactivity relative to the lignin; and
(c) cooking an aqueous composition comprising reactant components including the alkalated lignin, a polymerizable substance, and a crosslinking agent in the presence of a catalyst at a temperature of 60-95° C. for polymerizing the reactant components until a binder composition is formed.

US Pat. No. 10,246,613

LIGHT-REFLECTIVE ANISOTROPIC CONDUCTIVE ADHESIVE AND LIGHT-EMITTING DEVICE

DEXERIALS CORPORATION, T...

1. A light-reflective anisotropic conductive adhesive used for an electrically anisotropic conductive connection of a light-emitting element to a wiring substrate, the light-reflective anisotropic conductive adhesive comprisinga thermosetting resin composition,
conductive particles,
a curing agent for an epoxy resin, and
light-reflective insulating particles, wherein
the curing agent for an epoxy resin is an acid anhydride-based curing agent, and
the thermosetting resin composition includes a diglycidyl isocyanuryl modified polysiloxane represented by the formula (1)
wherein in the formula, R represents an alkyl group or an aryl group, and n represents an integer of 1 to 40.

US Pat. No. 10,246,611

TRANSPARENT FILM

SUMITOMO CHEMICAL COMPANY...

1. A transparent film having a polysiloxane backbone,wherein the transparent film has a structure (a) in which a fluorine-containing group having a perfluoroalkyl group or a perfluoropolyether group on the free end side thereof is bonded to a silicon atom of the polysiloxane backbone,
the fluorine-containing group having the perfluoroalkyl group on the free end side thereof is a group represented by the following formula (3-1) or (4-1),

in the formula (3-1),
Rf represents a fluorine atom or an alkyl group which has 1 to 20 carbon atoms and is substituted with one or more fluorine atoms,
Rf2 each independently represents a fluorine atom or an alkyl group which has 1 to 20 carbon atoms and is substituted with one or more fluorine atoms, R3 each independently represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms,
D each independently represents —O—, —COO—, —OCO—, —NR—, —NRCO—, or —CONR—, wherein R represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or a fluorine-containing alkyl group having 1 to 4 carbon atoms,
a2, c2, d2, and e2 are each independently an integer of not less than 0 and not more than 600, and the sum total of a2, b2, c2, d2, and e2 is 13 or more,
b2 is not less than 20 and not more than 600,
in the formula (4-1),
Rf represents a fluorine atom or an alkyl group which has 1 to 20 carbon atoms and is substituted with one or more fluorine atoms,
Rf3 each independently represents a fluorine atom or an alkyl group which has 1 to 20 carbon atoms and is substituted with one or more fluorine atoms, R5 each independently represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms,
G each independently represents —O—, —COO—, —OCO—, —NR—, —NRCO—, or —CONR—, wherein R represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or a fluorine-containing alkyl group having 1 to 4 carbon atoms,
Y each independently represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms,
Z represents a hydrogen atom or a halogen atom,
a3, c3, d3, and e3 are each independently an integer of not less than 0 and not more than 600, and the sum total of a3, b3, c3, d3, and e3 is 13 or more,
b3 is not less than 20 and not more than 600,
h3 is an integer of not less than 0 and not more than 2,
q is an integer of not less than 1 and not more than 10,
the fluorine-containing groups are bonded to some silicon atoms of the polysiloxane backbone in the structure (a),
the transparent film has a structure (b) in which carbon fluoride-containing groups or hydrolysable silane oligomer residue are bonded to some of the remaining silicon atoms of the polysiloxane backbone,
the molecular length of the structure (b) is shorter than the molecular length of the structure (a), and
the transparent film has a slip rate of 0.2 mm/s or more for a 120 ?l waterdrop on an 8° incline.

US Pat. No. 10,246,604

METHOD FOR PRODUCING VINYL POLYMER-CONTAINING AQUEOUS LIQUID AND METHOD FOR PRODUCING WATER/OIL RESISTANT AGENT

AGC Inc., Chiyoda-ku (JP...

1. A production method of a vinyl polymer aqueous liquid, the production method comprising:filling a closed container having a gas outlet with a mixed liquid containing water and a hydrophilic organic solvent with a boiling point of lower than 10020 C., wherein a vinyl polymer having hydrophobic groups and hydrophilic groups is dissolved or dispersed, to form a liquid phase and a gas phase;
forming a part of the liquid of the liquid phase into small droplets;
bringing the small droplets into contact with the gas phase to vaporize the hydrophilic organic solvent in the small droplets; and
removing the gas of the gas phase containing the vaporized hydrophilic organic solvent from the gas outlet of the closed container, whereby the amount of the hydrophilic organic solvent in the liquid phase is reduced to at most 1 mass % per the total amount of the hydrophilic organic solvent and water.

US Pat. No. 10,246,603

COATING MATERIAL COMPOSITION, SOLVENT-BASED COATING MATERIAL, AQUEOUS COATING MATERIAL, POWDER COATING MATERIAL AND COATED ARTICLE

AGC Inc., Chiyoda-ku (JP...

1. A coating material composition, comprising:a fluorinated copolymer (A); and
a pigment (B),
wherein
the fluorinated copolymer (A) has units represented by the following formula (1) and units represented by the following formula (2),
a number average molecular weight of the fluorinated copolymer (A) is from 10,000 to 100,000,
a hydroxy value of the fluorinated copolymer (A) is at least 100 mgKOH/g, and
a content of the pigment (B) is from 20 to 200 parts by mass, per 100 parts by mass of the fluorinated copolymer (A):

where in the formula (1), X and Y are each independently H, F, CF3 or Cl.

US Pat. No. 10,246,600

PREPARATION OF HIGH SOLID YELLOW PIGMENT SLURRY

BEHR PROCESS CORPORATION,...

1. A method comprising:a) combining a dispersant having pigment affinic groups with water to form an aqueous dispersant mixture, the dispersant having pigment affinic groups including a polyacrylate backbone and polyetheramine side chains attached to the polyacrylate backbone, further including an additional dispersant that is ammonium salt of a polycarboxylated polymer or copolymer;
b) adding at least one pigment to the aqueous dispersant mixture to form an aqueous pigment composition; and
c) grinding the aqueous pigment composition until the average particle size is less than 30 microns to form a pigmented aqueous slurry, the aqueous pigment composition including about 30 to 60 weight percent pigment wherein the pigment has a color with a CIE 1931 color space dominant wavelength from 570 to 590 nm.

US Pat. No. 10,246,564

END-MODIFIED CONJUGATED DIENE POLYMER AND METHOD FOR PREPARING THE SAME

Korea Kumho Petrochemical...

1. A method for preparing an end-modified conjugated diene polymer, comprising:(a) polymerizing one or two of a conjugated diene monomer and an aromatic vinyl monomer to form a living polymer in the presence of a solvent, a lewis base, and an organometallic compound; and
(b) reacting the living polymer with a compound represented by Formula 2 below:

to modify an end of the living polymer,
wherein R1 to R8 are each C1-C20 saturated or unsaturated hydrocarbon chains; X is carbon (C), silicon (Si), or nitrogen (N); a is 1; b, c and d are each integers of 0 to 3 satisfying an equation of b+c+d=3; and n is an integer of 1 to 200.

US Pat. No. 10,246,563

PHOTOSTABILIZER MASTER BATCH AND METHOD FOR MANUFACTURING SAME

ADEKA CORPORATION, Tokyo...

1. A photostabilizer masterbatch obtained by adding and mixing 80 to 300 parts by mass of (B) a hindered amine compound represented by the following Formula (1) with respect to 100 parts by mass of (A) a silica produced by a wet process and subsequently further adding and mixing 5 to 50 parts by mass of (C) a silica produced by a dry process:
(wherein, R1 represents a hydrogen atom, a hydroxy group, an alkyl, hydroxyalkyl, alkoxy or hydroxyalkoxy group having 1 to 30 carbon atoms, or an oxy radical; and R2 represents an alkyl group having 1 to 30 carbon atoms, an alkenyl group having 2 to 30 carbon atoms, or a group represented by the following Formula (2))

(wherein, R3 represents the same as R1 in said Formula (1)).

US Pat. No. 10,246,561

METHOD OF MAKING SILVER-CONTAINING DISPERSIONS WITH NITROGENOUS BASES

EASTMAN KODAK COMPANY, R...

1. A method comprising, in sequence:A) mixing:
(a) one or more polymers selected from one or more of cellulose acetate, cellulose acetate phthalate, cellulose acetate butyrate, cellulose acetate propionate, cellulose acetate trimellitate, hydroxypropylmethyl cellulose phthalate, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose, and carboxymethyl cellulose;
(b) reducible silver ions present in an amount of a weight ratio of (b) reducible silver ions to the one or more (a) polymers of at least 5:1 and up to and including 50:1; and
(c) one or more organic solvents, each of which has a boiling point at atmospheric pressure of at least 100° C. and up to but less than 500° C., wherein the Hansen parameter (?TPolymer) of each of the one or more polymers is less than or equal to the Hansen parameter (?TSolvent) of each of the one or more organic solvents,
to form a premix solution;
B) heating the premix solution to a temperature of at least 75° C.;
C) while keeping the premix solution at the temperature of at least 75° C., adding a (d) nitrogenous base having a pKa in acetonitrile of at least 15 and up to and including 25 at 25° C., to provide a concentration of the (d) nitrogenous base in an equimolar amount or in molar excess in relation to the amount of (b) reducible silver ions,
to form a silver nanoparticle composite;
D) after cooling, isolating the silver nanoparticle composite; and
E) re-dispersing the silver nanoparticle composite in the same or different one or more (c) organic solvents used in A), to provide a non-aqueous silver-containing dispersion comprising the silver nanoparticle composite.

US Pat. No. 10,246,552

PHOTOSTABILIZING POLYMER

SurfTech Corporation, La...

1. A photostabilizing polymer prepared by the esterification reaction of:1. a photo-absorbing group having the following structure:

wherein;
x is an integer ranging from 1 to 10;
2. a diacid independently selected from the group consisting of:
a. a fatty acid having to the following structure:
HOOC—R3—COOH
wherein;
R3 is alkyl containing 2 to 12 carbon atoms;
b. dimer Acid;
c. hydrogenated dimer acid;
d. mixtures thereof;
and
3. a diol having the following structure:
HO—R4—OH
wherein;
R4 is alkyl ranging from 3 to 12 carbons; and
4. a monofunctional alcohol independently selected from the group consisting of:
a. a branched alkyl having the structure:

wherein;
a is an integer ranging from 3-15;
b is an integer ranging from 5-17;
and mixtures thereof;
b. a fatty alcohol having the structure:
R2—OH
wherein;
R2 is alkyl having 8 to 26 carbon atoms,
and mixtures thereof.

US Pat. No. 10,246,551

FLAME-RETARDANT POLYMERS DERIVED FROM POLYOLS AND POLYACIDS

International Business Ma...

1. A flame-retardant polymer formed by a process that includes:reacting a triol with an organophosphorus mono-chloride to produce an intermediate compound; and
reacting the intermediate compound with a polycarboxylic acid to form the flame-retardant polymer, wherein phosphorus is chemically bound to a polymer chain of the flame-retardant polymer.

US Pat. No. 10,246,539

QUASICRYSTALLINE STRUCTURES AND USES THEREOF

The Trustees of Princeton...

1. A method of detecting electromagnetic radiation comprising; a) providing: i) a quasicrystalline structure and ii) electromagnetic radiation; b) directing said electromagnetic radiation through said quasicrystalline structure; and c) detecting said electromagnetic radiation, andwherein said quasicrystalline structure exhibits a photonic band structure in a two- or three-dimensional space, said band structure having corresponding symmetry, which symmetry is forbidden in crystals, and which band structure comprises a complete band gap.

US Pat. No. 10,246,534

APPARATUS FOR PREPARING POLYBUTADIENE

LG Chem, Ltd., (KR)

1. An apparatus for preparing polybutadiene, the apparatus comprising:two first polymerization reactors arranged in parallel to reduce a plugging phenomenon, wherein butadiene monomer, a polymerization catalyst, and a solvent are supplied and the butadiene monomer is polymerized;
at least one second polymerization reactor arranged in series with the parallel-arranged two first polymerization reactors, wherein a first polymerization solution containing a butadiene polymer discharged from the parallel-arranged two first polymerization reactors is supplied and a butadiene polymerization reaction is performed; and
one or more condensers which condense gases discharged from the parallel-arranged two first polymerization reactors and the second polymerization reactor and supply a condensate to the parallel-arranged two first polymerization reactors and/or the second polymerization reactor,
wherein the gases discharged from the parallel-arranged two first polymerization reactors and the second polymerization reactor are condensed in different condensers connected to each reactor.

US Pat. No. 10,246,532

CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS

Basell Poliolefine Italia...

1. A solid catalyst component for the polymerization of olefins comprising:(i) Mg,
(ii) Ti,
(iii) halogen, and
(iv) an electron donor of formula (I)

wherein
R and R1 are selected from the group consisting of C1-C20 hydrocarbon groups, and C6-C14 aryl or alkylaryl groups, wherein R and R1 optionally contain a heteroatom selected from the group consisting of halogen, P, S, N, and O; and
R2 to R11 groups, equal to or different from each other, are selected from the group consisting of hydrogen, halogen and C1-C15 hydrocarbon groups which are optionally fused together to form one or more cycles with the proviso that R6 and R11 cannot join together to form a phenyl ring.

US Pat. No. 10,246,526

VULCANIZED RUBBER COMPOSITION AND PRODUCTION METHOD THEREOF

MITSUBISHI GAS CHEMICAL C...

1. A method for producing a vulcanized rubber composition, comprising:a first kneading step of obtaining a kneaded mixture comprising: a rubber component comprising at least one selected from the group consisting of natural rubbers and synthetic rubbers, a filler comprising an inorganic filler, and a sulfur-containing silane coupling agent;
a second kneading step of adding sulfur and a vulcanization accelerator to the kneaded mixture, followed by kneading, to thereby obtain an unvulcanized rubber composition; and
a vulcanization step of vulcanizing the unvulcanized rubber composition to thereby obtain a vulcanized rubber composition having a glass transition temperature of ?30° C. or more and 0° C. or less, wherein
at least one selected from the group consisting of compounds represented by formulae (1), (2), and (3) below is added, followed by kneading, in the first kneading step:
wherein X is an acid that forms a salt together with a guanidine moiety;wherein X is an acid that forms a salt together with a guanidine moiety, R1 and R2 are each independently any one selected from the group consisting of a hydrogen atom and an alkyl group, a cycloalkyl group, an aryl group, an alkyl aryl group, and an alkenyl group which have 1 to 18 carbon atoms, these groups each optionally having one or more substituents containing at least one selected from the group consisting of a sulfur atom, a nitrogen atom, and an oxygen atom; andwherein X is an acid that forms a salt together with a guanidine moiety.

US Pat. No. 10,246,482

NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF

Sage Therapeutics, Inc., ...

1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, wherein:R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, or heterocyclyl;
each of R2a and R2b is independently hydrogen, C1-C6 alkyl, halo, cyano, —ORA, or —NRBRC, or
R2a and R2b together with the carbon atom to which they are attached form a ring;
R3 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(O)RA, —C(O)ORA, or —C(O)NRBRC;
R4 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, or —ORA;
represents a single or double bond, wherein when one is a double bond, the other is a single bond;
wherein when the between —CR6 and —CR5aR5b is a double bond, then one of R5a or R5b is absent; and
when one of the is a double bond, R6 is absent;
each of R5a and R5b is independently absent, hydrogen, C1-C6 alkyl, or halo;
R6 is absent or hydrogen;
Z is —CR7aR7b—, wherein each of R7a and R7b is independently hydrogen or C1-C6 alkyl, or R7a and R7b, together with the carbon atom to which they are attached, form a ring;
RA is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
each of RB and RC is independently hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, or taken together with the atom to which they are attached form a ring.

US Pat. No. 10,246,480

COMPOUNDS FOR THE TREATMENT OF CANCER

1. A compound of Formula (III):
or a pharmaceutically acceptable salt thereof, wherein
R1a is selected from the group consisting of —H, —OH, and —F;
R1b is selected from the group consisting of —H, —OH, and —F, wherein at least one of R1a and R1b is —H;
R4a is selected from the group consisting of —H, —OH, and —F;
R4b is selected from the group consisting of —H, —OH, and —F, wherein at least one of R4a and R4b is —H;
P1 and P2 each independently has an S or R stereochemical configuration;
Z is —O— or —NH—;
X1a and X2a are the same or different and are independently selected from ?O or ?S;
X1b and X2b are the same or different and are independently selected from —OR5 and —SR5;
wherein R5 is selected from the group consisting of —H, —C1-6alkyl, —C(O)C1-6alkyl, and —CH2OC(O)OC1-6alkyl;
L1 in formula (III) is four, five, or six carbons in length, and is

wherein indicates a singe bond, a double bond, or a triple bond and wherein (i) either 0 or 1 occurrence of in L1 indicates a triple bond; or (ii) 0, 1, or 2 occurrences of in L1 indicates a double bond, wherein geometry about each double bond is cis or trans; and (iii) wherein when 1 occurrence of in L1 indicates a triple bond, 0 occurrences of in L1 indicates a double bond; and (iv) wherein, when 2 occurrences of in L1 indicate a double bond, those double bonds are either adjacent bonds or alternating bonds;
wherein X10, X11, X12, X13, X14, and X15 are independently selected from a bond, —CH2—, or —CH—, wherein the —CH2— or —CH— is unsubstituted or substituted by (i) —OH, (ii) —F, (iii) —Cl, (iv) —NH2, or (v) -D, and when X10 or X15 is a bond, that bond is not a double bond or triple bond;
and wherein any two adjacent members of the group including X10, X11, X12, X13, X14, and X15 may optionally form, with additional atoms, a C3 cycloalkyl or a C3 heterocycloalkyl, said C3 heterocycloalkyl including an N or O atom;
wherein B1 and B2 are independently selected from:
where the bonds at points q and r on B1 and B2 are attached at points q and r on Formula (III).

US Pat. No. 10,246,478

POLYENE MACROLIDE DERIVATIVE

1. A compound represented by formula (I):wherein X is a group of formula (II):or —N(RF)—CO—X1,wherein in formula (II) Ring C is substituted or unsubstituted aromatic carbocycle, substituted or unsubstituted non-aromatic carbocycle, substituted or unsubstituted aromatic heterocycle or substituted or unsubstituted non-aromatic heterocycle;
wherein RF is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted alkynyl; and
X1 is any one of following groups (III)-(VI):

wherein in formula (I) L, J1 and V1 are each independently hydrogen, halogen, hydroxy, substituted or unsubstituted amino or substituted or unsubstituted alkyloxy;
J2 and V2 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted alkynyl;or J1 and J2 and/or V1 and V2 may be taken together to form oxo;wherein in formula (III) or (IV) Ra1 and Rb1 are each independently, hydrogen, halogen, hydroxy, carboxy, substituted or unsubstituted amino, formyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted sulfamoyl, sulfo, cyano, substituted or unsubstituted ureido, guanidino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted alkyl ammonium, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted alkylphosphonyl, substituted or unsubstituted dialkynylphosphonyl, substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted alkenylcarbonyloxy, substituted or unsubstituted alkynylcarbonyloxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclylamino, substituted or unsubstituted non-aromatic carbocyclylamino, substituted or unsubstituted aromatic heterocyclylamino, substituted or unsubstituted non-aromatic heterocyclylamino, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl or substituted or unsubstituted non-aromatic heterocyclylsulfonyl;
Ra2 and Rb2 are each independently hydrogen, halogen, hydroxy, carboxy, substituted or unsubstituted amino, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted alkenylcarbonyloxy, substituted or unsubstituted alkynylcarbonyloxy, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxyalkyl, substituted or unsubstituted non-aromatic heterocyclyloxyalkenyl or substituted or unsubstituted non-aromatic heterocyclyloxyalkynyl;
Ra3 and Rb3 are each independently, hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxyalkyl, substituted or unsubstituted non-aromatic heterocyclyloxyalkenyl or substituted or unsubstituted non-aromatic heterocyclyloxyalkynyl;or Ra2 and Ra3 and/or Rb2 and Rb3 are each independently may be taken together to form oxo, substituted or unsubstituted imino or thioxo, or may be taken together with neighboring atoms to form substituted or unsubstituted non-aromatic carbocycle or substituted or unsubstituted non-aromatic heterocycle;Ra4, Rb4 and Rc4 are each independently, hydrogen, hydroxy, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl or substituted or unsubstituted non-aromatic carbocyclyl;
Rb5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted alkynyl;
wherein in formula (V) or (VI) Ring A and Ring B are each independently, substituted or unsubstituted nitrogen-containing aromatic heterocycle or substituted or unsubstituted nitrogen-containing non-aromatic heterocycle;
wherein in formula (III) T is a bond, —N(Ra5)— or —O—;
wherein the Ra5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl or substituted or unsubstituted alkynylcarbonyl;
wherein in formula (III) or (IV) m and n are each independently an integer of 0 to 10;
wherein in formula (I) Y is any one of following groups:

wherein in formula (VII) RA is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted alkynyl;
RB and RC are each independently hydrogen, hydroxy, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted alkynyl;or RB and RC may be taken together to form oxo, substituted or unsubstituted imino or thioxo, or may be taken together with neighboring atoms to form substituted or unsubstituted non-aromatic carbocycle or substituted or unsubstituted non-aromatic heterocycle;wherein in formula (VII) or (VIII) RD is hydrogen, hydroxy, carboxy, substituted or unsubstituted amino, substituted or unsubstituted carbamoyl, substituted or unsubstituted amidino, substituted or unsubstituted guanidino, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl or substituted or unsubstituted non-aromatic heterocyclyl;
wherein in formula (VIII) RE is hydrogen, hydroxy or substituted or unsubstituted amino;
wherein in formula (VII) q is an integer of 0 to 10;provided that the following compounds are excluded:the compounds which X is either of following groups; and Y is —NH2;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,246,467

SPIRO[3H-INDOLE-3,2?-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS

Boehringer Ingelheim Inte...

1. A compound of formula (I)whereinR1 is a group, optionally substituted by one or more, identical or different Rb1 and/or Rc1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
each Rb1 is independently selected from among —ORc1, —NRc1Rc1, halogen, —CN, —C(O)Rc1, —C(O)ORc1, —C(O)NRc1Rc1, —S(O)2Rc1, —S(O)2NRc1Rc1, —NHC(O)Rc1 and —N(C1-4alkyl)C(O)Rc1;
each Rc1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd1 and/or Re1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
each Rd1 is independently selected from among, —ORe1, NRe1Re1 halogen, —CN,
C(O)Re1, —C(O)ORe1, —C(O)NRe1Re1, S(O)2Re1, —S(O)2NRe1Re1, —NHC(O)Re1 and —N(C1-4alkyl)C(O)Re1;
each Re1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf1 and/or Rg1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
each Rf1 is independently selected from among —ORg1, —NRg1Rg1, halogen, —CN, —C(O)Rg1, —C(O)ORg1, —C(O)NRg1Rg1, —S(O)2Rg1, —S(O)2NRg1Rg1, —NHC(O)Rg1 and —N(C1-4alkyl)C(O)Rg1;
each Rg1 is independently selected from among hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
R2 and R3, each independently, is selected from among hydrogen, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl, wherein this C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl is optionally substituted by one or more, identical or different Rb2 and/or Rc2;
each Rb2 is independently selected from among —ORc2, —NRc2Rc2, halogen, —CN, —C(O)Rc2, —C(O)ORc2, —C(O)NRc2Rc2, —S(O)2Rc2, —S(O)2NRc2Rc2, —NHC(O)Rc2 and —N(C1-4alkyl)C(O)Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 and/or Re2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
each Rd2 is independently selected from among —ORe2, —NRe2Re2, halogen, —CN, —C(O)Re2, —C(O)ORe2, —C(O)NRe2Re2, —S(O)2Re2, —S(O)2NRe2Re2, —NHC(O)Re2 and —N(C1-4alkyl)C(O)Re2;
each Re2 independently of one another denotes hydrogen or a group selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
A is selected from among phenyl and 5-6 membered heteroaryl;
each R4 is independently selected from among Ra4 and Rb4;
each Ra4 independently of one another is a group, optionally substituted by one or more, identical or different Rb4 and/or Rc4, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
each Rb4 is independently selected from among —ORc4, —NRc4Rc4, halogen, —CN, —C(O)Rc4, —C(O)ORc4, —C(O)NRc4Rc4, —C(O)NRg4ORc4, —S(O)2Rc4, —S(O)2NRc4Rc4, —NHSO2Rc4, —N(C1-4alkyl)SO2Rc4, —NHC(O)Rc4 and —N(C1-4alkyl)C(O)Rc4;
each Rc4 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd4 and/or Re4, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
each Rd4 is independently selected from among —ORe4, —NRe4Re4, halogen, —CN, —C(O)Re4, —C(O)ORe4, —C(O)NRe4Re4, —C(O)NRg4ORe4, —S(O)2Re4, —S(O)2NRe4Re4, —NHC(O)Re4 and —N(C1-4alkyl)C(O)Re4;
each Re4 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf4 and/or Rg4, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
each Rf4 is independently selected from among —ORg4, —NRg4Rg4, halogen, —CN, —C(O)Rg4, —C(O)ORg4, —C(O)NRg4Rg4, —C(O)NRg4ORg4, —S(O)2Rg4, —S(O)2NRg4Rg4, —NHC(O)Rg4 and —N(C1-4alkyl)C(O)Rg4;
each Rg4 is independently selected from among hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
r denotes the number 0, 1, 2 or 3
R5 and R6, each independently, is selected from among hydrogen, C1-4alkyl and C1-4haloalkyl;
n denotes the number 0;
each R7 is independently selected from among halogen, C1-4alkyl, —CN, C1-4haloalkyl, —OC1-4alkyl and —OC1-4haloalkyl;
q denotes the number 0, 1, 2 or 3;
W, X and Y is each independently selected from —N? and —CH?
with the proviso that the hydrogen in each —CH? may be replaced by a substituent R7 if present and that a maximum of two of W, X and Y can be —N?;
V is oxygen or sulfur;
or a salt thereof.

US Pat. No. 10,246,462

CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF

FLX BIO, INC., South San...

1. A compound having structural Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
A is a substituted or unsubstituted heterocycloalkyl;
X1 is N;
X2 is N;
X3 is CR10;
X4 is C, CR11 or N;
z1 is an integer from 0 to 5;
z2 is an integer from 0 to 13;
z3 is an integer from 0 to 12;
z4 is an integer from 0 to 3;
is a single bond or double bond, wherein if is a single bond, then X4 is CR11 or N, and if is a double bond, then X4 is C;
L7 is a bond, —O—, —S—, —NR7B—, —C(O)—, —C(O)O—, —S(O)—, —S(O)2—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; wherein each substituted alkylene, substituted heteroalkylene, substituted cycoalkylene, substituted heterocycloalkylene, substituted arylene, or substituted heteroarylene is substituted with at least one substituent group;
R1 is hydrogen, halogen, —CX1.13, —CHX1.12, —CH2X1.1, —CN, —SOn1R1A, —SOv1NR1BR1C, —NHNR1BR1C, —ONR1BR1C, —NHC(O)NHNR1BR1C, —NHC(O)NR1BR1C, —N(O)m1, —NR1BR1C, —C(O)R1D, —C(O)OR1D, —C(O)NR1BR1C, —OR1A, —NR1BSO2R1A, —NR1BC(O)R1D, —NR1BC(O)OR1D, —NR1BOR1D, —OCX1.13, —OCHX1.12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; wherein each substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteroaryl is substituted with at least one substituent group;
R2 is hydrogen, halogen, —CX2.13, —CHX2.12, —CH2X2.1, —CN, —SOn2R2A, —SOv2NR2BR2C, —NHNR2BR2C, —ONR2BR2C, —NHC(O)NHNR2BR2C, —NHC(O)NR2BR2C, —N(O)m2, —NR2BR2C, —C(O)R2D, —C(O)OR2D, —C(O)NR2BR2C, —OR2A, —NR2BSO2R2A, —NR2BC(O)R2D, —NR2BC(O)OR2D, —NR2BOR2D, —OCX2.13, —OCHX2.12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; wherein each substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocloalkyl, substituted aryl, or substituted heteroaryl is substituted with at least one substituent group;
R3 is independently hydrogen, halogen, —CX3.13, —CHX3.12, —CH2X3.1, —CN, —SOn3R3A, —SOv3NR3BR3C, —NHNR3BR3C, —ONR3BR3C, —NHC(O)NHNR3BR3C, —NHC(O)NR3BR3C, —N(O)m3, —NR3BR3C, —C(O)R3D, —C(O)OR3D, —C(O)NR3BR3C, —OR3A, —NR3BSO2R3A, —NR3BC(O)R3D, —NR3BC(O)OR3D, —NR3BOR3D, —OCX3.13, —OCHX3.12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein each substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteroaryl is substituted with at least on substituent group;
R4 is hydrogen, halogen, —CX4.13, —CHX4.12, —CH2X4.1, —CN, —SOn4R4A, —SOv4NR4BR4C, —NHNR4BR4C, —ONR4BR4C, —NHC(O)NHNR4BR4C, —NHC(O)NR4BR4C, —N(O)m4, —NR4BR4C, —C(O)R4D, —C(O)OR4D, —C(O)NR4BR4C, —OR4A, —NR4BSO2R4A, —NR4BC(O)R4D, —NR4BC(O)OR4D, —NR4BOR4D, —OCX4.13, —OCHX4.12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein each substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteroaryl is substituted with at least one substituent group;
R5 is independently hydrogen, halogen, oxo, —CX5.13, —CHX5.12, —CH2X5.1, —CN, —SOn5R5A, —SOv5NR5BR5C, —NHNR5BR5C, —ONR5BR5C, —NHC(O)NHNR5BR5C, —NHC(O)NR5BR5C, —N(O)m5, —NR5BR5C, —C(O)R5D, —C(O)OR5D, —C(O)NR5BR5C, —OR5A, —NR5BSO2R5A, —NR5BC(O)R5D, —NR5BC(O)OR5D, —NR5BOR5D, —OCX5.13, —OCHX5.12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein each substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted hetercycloalkyl, substituted aryl, or substituted heteroaryl is substituted with at least one substituent group;
R6 is independently hydrogen, halogen, oxo, —CX6.13, —CHX6.12, —CH2X6.1, —CN, —SOn6R6A, —SOv6NR6BR6C, —NHNR6BR6C, —ONR6BR6C, —NHC(O)NHNR6BR6C, —NHC(O)NR6BR6C, —N(O)m6, —NR6BR6C, —C(O)R6D, —C(O)OR6D, —C(O)NR6BR6C, —OR6A, —NR6BSO2R6A, —NR6BC(O)R6D, —NR6BC(O)OR6D, —NR6BOR6D, —OCX6.13, —OCHX6.12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein each substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteroaryl is substituted with at least one substituent group;
R10 is hydrogen, halogen, —CX10.13, —CHX10.12, —CH2X10.1, —CN, —SOn10R10A, —SOv10NR10BR10C, —NHNR10BR10C, —ONR10BR10C, —NHC(O)NHNR10BR10C, —NHC(O)NR10BR10C, —N(O)m10, —NR10BR10C, —C(O)R10D, —C(O)OR10D, —C(O)NR10BR10C, —OR10A, —NR10BSO2R10A, —NR10BC(O)R10D, —NR10BC(O)OR10D, —NR10BOR10D, —OCX10.13, —OCHX10.12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; wherein each substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteroaryl is substituted with at least one substituent group;
R11 is hydrogen, halogen, —CX11.13, —CHX11.12, —CH2X11.1, —CN, —SOn1R11A,
—SOv11NR11BR11C, —NHNR11BR11C, —ONR11BR11C, —NHC(O)NHNR11BR11C, —NHC(O)NR11BR11C, —N(O)m11, —NR11BR11C, —C(O)R11D, —C(O)OR11D, —C(O)NR11BR11C, —OR11A, —NR11BSO2R11A, —NR11BC(O)R11D, —NR11BC(O)OR11D, —NR11BOR11D, —OCX11.13, —OCHX11.12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; wherein each substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteroaryl is substituted with at least one substituent group;
R1A, R1B, R1C, R1D, R2A, R2B, R2C, R2D, R3A, R3B, R3C, R3D, R4A, R4B, R4C, R4D, R5A, R5B, R5C, R5D, R6A, R6B, R6C, R6D, R7B, R10A, R10B, R10C, R10D, R11A, R11B, R11C and R11D are independently hydrogen, halogen, —CF3, —CCl3, —CBr3, —CI3, —COOH, —CONH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R1B and R1C, R2B and R2C, R3B and R3C, R4B and R4C, R5B and R5C, R6B and R6C, R10B and R10C, R11B and R11C substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; wherein each substituted alkyl, substituted heteroalkyl, substituted cycloalkyl, substituted heterocycloalkyl, substituted aryl, or substituted heteroaryl is substituted with at least one substituent group;
n1, n2, n3, n4, n5, n6, n10 and n11 are independently an integer from 0 to 4;
m1, m2, m3, m4, m5, m6, m10, m11, v1, v2, v3, v4, v5, v6, v10, and v11 are independently 1 or 2; and
X1.1, X2.1, X3.1, X4.1, X5.1, X6.1, X10.1, and X11.1 are independently —Cl, —Br, —I or —F.

US Pat. No. 10,246,459

USE OF TETRAMIC ACID DERIVATIVES AS NEMATICIDES

SYNGENTA PARTICIPATIONS A...

1. A method for reducing nematode damage to a plant comprising:i) applying a first composition with nematicidal properties to a seed prior to planting and/or to the soil surrounding a planted seed or plant;
ii) and applying a second composition comprising a systemic nematicidal compound to an aerial plant part of said previously treated plant or plant produced from said previously treated seed;wherein the systemic nematicidal compound is selected from a compound according to the following formula:whereinG is hydrogen or a latentiating group; and
A is hydrogen, C1-6alkyl, C1-6haloalkyl, or C1-6alkoxy;or an agrochemically acceptable salt or an N-oxide thereof.

US Pat. No. 10,246,457

INDAZOLE AND AZAINDAZOLE BTK INHIBITORS

1. A compound of Formula (I)wherein:X1 is N or C(H);
X2 is N or C(R6);
R1 is H, C1-3akyl, or —CH2—R1a, wherein R1a is phenyl or pyridyl;
R6 is H or C1-3alkyl;
R7 is:
(a.) a group of the formula —C(O)N(R7a)(R7b), wherein R7a and R7b are independently H or C1-3alkyl; or alternatively, R7a and R7b together with the N to which they are attached form a 5- to 6-membered heterocyclyl optionally containing 1 additional heteroatom selected from N or O;
(b.) Cy, wherein Cy is phenyl or a 5- or 6-membered heteroaryl containing 1 to 3 N ring atoms; wherein Cy is unsubstituted or substituted by 1 to 2 Rc substituents selected from:
(i.) C1-4alkyl,
(ii.) a group of the formula —C(R7d)2CO2H,
wherein R7d is H or C1-3alkyl;
(iii.) —CH2CH2OCH3; or
(iv.) tetrahydropyranyl;
or alternatively, two Rc substituents, together with the atoms to which they are attached form a 5- to 6-membered heterocyclyl containing 1 N ring atom;
(c.) —C(O)OH;
(d.) H;
(e.) C1-3alkyl; or
(f.) C1-3fluoroalkyl;
R8 is H, C1-3alkyl or C1-3hydroxyalkyl;
R9 is:

 ora pharmaceutically acceptable salt thereof.

US Pat. No. 10,246,455

HISTONE DEACETYLASE INHIBITORS

Taipei Medical University...

1. A compound of formula (I):whereinR1 is SO2Ra, in which Ra is phenyl substituted with

R2 is H;
R3 is H;
X is C;
A is unsubstituted pyridine; and
is a double bond,or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,246,452

MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO

Dow AgroSciences LLC, In...

1. A molecule having the following formula (“Formula One” and/or “Formula Two”)
wherein:
(A) Ar1 is selected from
(1) furanyl, phenyl, pyridazinyl, pyridyl, pyrimidinyl, or thienyl, or
(2) substituted furanyl, substituted phenyl, substituted pyridazinyl, substituted pyridyl, substituted pyrimidinyl, or substituted thienyl,
wherein said substituted furanyl, substituted phenyl, substituted pyridazinyl, substituted pyridyl, substituted pyrimidinyl, or substituted thienyl, has one or more substituents independently selected from H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, OSO2—(C1-C8)alkyl, C(O)—NRxRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and phenoxy,
wherein each alkyl, cycloalkyl, alkoxy, alkenyl, alkynyl, phenyl, and phenoxy substituent may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)—NRxRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and phenoxy;
(B) Het is a 5- or 6-membered, saturated or unsaturated, heterocyclic ring, containing one or more heteroatoms independently selected from nitrogen, sulfur, or oxygen, and where Ar1 and Ar2 are 1,3 for a 5-membered ring and 1,3 or 1,4 for a 6-membered ring, and where said heterocyclic ring may also be substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, oxo, (C1-C8)alkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)2—(C1-C8)alkyl, OSO2—(C1-C8)alkyl, C(O)—NRxRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and phenoxy,
wherein each alkyl, cycloalkyl, alkoxy, alkenyl, alkynyl, phenyl, and phenoxy substituent may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)—NRxRy, (C1-C8)alkyl-NR xRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and phenoxy;
(C) Ar2 is selected from
(1) furanyl, phenyl, pyridazinyl, pyridyl, pyrimidinyl, or thienyl, or
(2) substituted furanyl, substituted phenyl, substituted pyridazinyl, substituted pyridyl, substituted pyrimidinyl, or substituted thienyl,
wherein said substituted furanyl, substituted phenyl, substituted pyridazinyl, substituted pyridyl, substituted pyrimidinyl, or substituted thienyl, has one or more substituents independently selected from H, F, Cl, Br, I, CN, NO2, NRxRy, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, OSO2—(C1-C8)alkyl, C(O)—NRxRy, (C1-C8)alkyl-NR xRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and phenoxy,
wherein each alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, phenyl, and phenoxy substituent may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)—NR xRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and phenoxy;
(D) L is linker selected from
(1) a saturated or unsaturated, substituted linear (C1-C4)hydrocarbyl linker, and
(2) a saturated or unsaturated, substituted cyclic (C3-C8)hydrocarbyl group linker,
wherein each of said linkers connects Ar2 to NY and
wherein said substituted linear (C1-C4)hydrocarbyl linker and substituted cyclic (C3-C8)hydrocarbyl linker has one or more substituents independently selected from R8, R9, R10, R11, and R12, wherein each R8, R9, R10, R11, and R12, is selected from
—NRAC(O)—RB, —NRAC(O)O—RB, —C(O)—OH, or —C(O)O—RB,
where RA is H or (C1-C8)alkyl, and RB is (C1-C8)alkyl or (C1-C8)alkyl substituted with at least one phenyl;
(E) R1 is selected from the group consisting of H, (C1-C8)alkyl, (C3-C8)cycloalkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, C(O)—NR xRy, (C1-C8)alkyl-NRxRy, C(O)O—(C1-C8)alkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)—(C1-C8)alkyl, (C1-C8)alkyl-S(O)2—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)O—(C1-C8)alkyl, (C1-C8)alkyl-C(O)O—(C1-C8)alkyl, C(O)alkyl, (C1-C8)alkyl-C(O)—(C1-C8)alkyl, (C1-C8)alkylphenyl, and (C1-C8)alkyl-O-phenyl,
wherein each alkyl, cycloalkyl, alkenyl, and alkynyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, oxo, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)—NRxRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and phenoxy;
(F) Q and Q1 are each independently selected from the group consisting of O and S;
(G) R2 is selected from the group consisting of (J), H, (C1-C8)alkyl, (C3-C8)cycloalkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, C(O)—(C1-C8)alkyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, (C1-C8)alkylphenyl, (C1-C8)alkyl-O—phenyl, C(O)—(Het-1), (Het-1), (C1-C8)alkyl-(Het-1), (C1-C8)alkyl-OC(O)—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)O—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)—NR xRy, (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl-(Het-1), (C1-C8)alkyl-C(O)—(Het-1), (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl(NRxRy)—C(O)OH, (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl-NRxRy, (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl-N(Rx)—C(O)O—(C1-C8)alkyl, (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl(N(Rx)—(O)O—(C1-C8)alkyl)-C(O)OH, (C1-C8)alkyl-C(O)—(Het-1)—C(O)O—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)O—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)—(C3-C8)cycloalkyl, (C1-C8)alkyl-OC(O)-(Het-1), (C1-C8)alkyl-OC(O)—(C1-C8)alkyl-N(Rx)—C(O)O—(C1-C8)alkyl, (C1-C8)alkyl-NRxRy, (C1-C8)alkyl-S(O)n—(Het-1), and (C1-C8)alkyl-O—(Het-1),
wherein each alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, and (Het-1) may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, NRxRy, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)H, C(O)OH, C(O)—NRxRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl), phenyl, phenoxy, Si((C1-C8)alkyl)3, S(O)n—NRxRy, and (Het-1);
(H) R3 is selected from the group consisting of (C3-C8)cycloalkyl, phenyl, (C1-C8)alkylphenyl, (C1-C8)alkyl-O—phenyl, (C2-C8)alkenyl-O—phenyl, (Het-1), (C1-C8)alkyl-(Het-1), and (C1-C8)alkyl-O—(Het-1),
wherein each alkyl, cycloalkyl, alkenyl, phenyl, and (Het-1) may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, NRxRy, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)H, C(O)—NRxRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C1-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, O—(C1-C8)alkyl, S—(C1-C8)alkyl, (C1-C8)alkyl-O—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, phenoxy, and (Het-1),
(I) R4 is selected from the group consisting of (J), H, (C1-C8)alkyl, (C3-C8)cycloalkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, C(O)—(C1-C8)alkyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, (C1-C8)alkylphenyl, (C1-C8)alkyl-O—phenyl, C(O)—(Het-1), (Het-1), (C1-C8)alkyl-(Het-1), (C1-C8)alkyl-OC(O)—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)O—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)—NR xRy, (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl-(Het-1), (C1-C8)alkyl-C(O)—(Het-1), (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl(NRxRy)—C(O)OH, (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl-NRxRy, (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl-N(Rx)—C(O)O—(C1-C8)alkyl, (C1-C8)alkyl-C(O)—N(Rx)(C1-C8)alkyl(N(Rx)—C(O)O—(C1-C8)alkyl)-C(O)OH, (C1-C8)alkyl-C(O)—(Het-1)-C(O)O—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)O—(C1-C8)alkyl, (C1-C8)alkyl-OC(O)—(C1-C8)alkyl, (C1-C8)alkyl -OC(O)—(C3-C8)cycloalkyl, (C1-C8)alkyl-OC(O)—(Het-1), (C1-C8)alkyl-OC(O)—(C1-C8)alkyl-N(Rx)—C(O)O—(C1-C8)alkyl, (C1-C8)alkyl-NRxRy, (C1-C8)alkyl-S(O)n—(Het-1), and (C1-C8)alkyl-O—(Het-1),
wherein each alkyl, cycloalkyl, alkenyl, alkynyl, phenyl, and (Het-1) may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, NRxRy, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)H, C(O)OH, C(O)—NR xRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, phenoxy, Si((C1-C8)alkyl)3, S(O)n—NRxRy, and (Het-1);
(J) R2 and R4 together with Cx(Q1)(Nx), may form a 4- to 7-membered saturated or unsaturated, heterocyclic ring, which may further contain one or more heteroatoms selected from the group consisting of nitrogen, sulfur, and oxygen,
wherein each heterocyclic ring may be optionally substituted with one or more substituents independently selected from the group consisting of R5, R6, and R7,
wherein R5, R6, and R7 are each independently selected from the group consisting of H, F, Cl, Br, I, CN, OH, NO2, NRxRy, oxo, thioxo, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)H, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n-—C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and (Het-1);
(K) Rx and Ry are each independently selected from the group consisting of H, (C1-C8)alkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, OSO2—(C1-C8)alkyl, C(O)H, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, , C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and (C1-C8)alkylphenyl,
wherein each alkyl, cycloalkyl, alkoxy, alkenyl, alkynyl, phenyl, and alkylphenyl may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)H, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and (Het-1);
(L) (Het-1) is a 5- or 6-membered, saturated or unsaturated, heterocyclic ring, containing one or more heteroatoms independently selected from nitrogen, sulfur or oxygen,
wherein said heterocyclic ring may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, oxo, (C1-C8)alkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, OSO2—(C1-C8)alkyl, C(O)—NRxRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C3-Cs)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-Cs)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and phenoxy,
wherein each alkyl, cycloalkyl, alkoxy, alkenyl, alkynyl, phenyl, and phenoxy substituent may be optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, (C1-C8)haloalkyl, (C3-C8)cycloalkyl, (C1-C8)alkoxy, (C1-C8)haloalkoxy, (C2-C8)alkenyl, (C2-C8)alkynyl, S(O)n—(C1-C8)alkyl, S(O)n—(C1-C8)haloalkyl, OSO2—(C1-C8)alkyl, OSO2—(C1-C8)haloalkyl, C(O)—NRxRy, (C1-C8)alkyl-NRxRy, C(O)—(C1-C8)alkyl, C(O)O—(C1-C8)alkyl, C(O)—(C1-C8)haloalkyl, C(O)O—(C1-C8)haloalkyl, C(O)—(C3-C8)cycloalkyl, C(O)O—(C3-C8)cycloalkyl, C(O)—(C2-C8)alkenyl, C(O)O—(C2-C8)alkenyl, (C1-C8)alkyl-O—(C1-C8)alkyl, (C1-C8)alkyl-S(O)n—(C1-C8)alkyl, C(O)—(C1-C8)alkyl-C(O)O—(C1-C8)alkyl, phenyl, and phenoxy;
(M) n is each individually 0, 1, or 2; and
N-oxides, agriculturally acceptable acid addition salts, salts, solvates, esters, crystal polymorphs, isotopes, resolved stereoisomers, and/or tautomers thereof.

US Pat. No. 10,246,447

3-(6-CHLORO-3-OXO-3,4-DIHYDRO-(2H)-1,4-BENZOXAZIN-4-YL) PROPANOIC ACID DERIVATIVES AND THEIR USE AS KMO INHIBITORS

GlaxoSmithKline Intellect...

1. A compound of Formula (I):
wherein:
R1 is heteroaryl optionally substituted by methyl, ethyl, or halo; and
R2 is H, methyl or ethyl;
wherein:
heteroaryl as defined for R1 is selected from the group consisting of oxazolyl, pyridinyl, pyrimidinyl, pyridazinyl and imidazolyl,
wherein:
the oxazolyl, pyridinyl, pyrimidinyl, and pyridazinyl, respectively, is optionally substituted by methyl, ethyl, chloro or fluoro; or
a pharmaceutically acceptable salt thereof.

US Pat. No. 10,246,441

AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT

IDEMITSU KOSAN CO., LTD.,...

1. An organic electroluminescence device, comprising:a cathode:
an anode; and
an organic thin-film layer interposed between the cathode and the anode, wherein the organic thin-film layer comprises a light emitting layer and at least one selected from the group consisting of a hole transporting layer and a hole injecting layer, and
wherein at least one selected from the group consisting of the hole transporting layer and the hole injecting layer comprises an aromatic amine derivative represented by formula (9):

wherein:
at least one of Ar3 to Ar5 represents the substituent A and at least one of Ar3 to Ar5 represents the substituent B;
a group out of Ar3 to Ar5 except the substituent A and the substituent B represents a substituted or unsubstituted aryl group having 6 to 25 ring carbon atoms or a substituted or unsubstituted heteroaryl group having 5 to 25 ring carbon atoms, wherein an optional substituent of the aryl group and the heteroaryl group is a linear or branched alkyl group having 1 to 15 carbon atoms, a cycloalkyl group having 3 to 15 ring carbon atoms, a trialkylsilyl group having linear or branched alkyl groups each having 1 to 15 carbon atoms, a triarylsilyl group having aryl groups each having 6 to 25 ring carbon atoms, an alkylarylsilyl group having a linear or branched alkyl group having 1 to 15 carbon atoms and an aryl group having 6 to 25 ring carbon atoms, an aryl group having 6 to 25 ring carbon atoms, a halogen atom, or a cyano group:
the substituent A is represented by formula (1);
the substituent B is represented by formula (2);

wherein:
L1 and L2 each represent a substituted or unsubstituted arylene group having 6 to 25 ring carbon atoms, and a substituent which L1 and L2 may have is a linear or branched alkyl group having 1 to 15 carbon atoms, a cycloalkyl group having 3 to 15 ring carbon atoms, a trialkylsilyl group having linear or branched alkyl groups each having 1 to 15 carbon atoms, a triarylsilyl group having aryl groups each having 6 to 25 ring carbon atoms, an alkylarylsilyl group having a linear or branched alkyl group having 1 to 15 carbon atoms and an aryl group having 6 to 25 ring carbon atoms, an aryl group having 6 to 25 ring carbon atoms, a halogen atom, or a cyano group;
Ar1 represents a substituted or unsubstituted aryl group having 6 to 25 ring carbon atoms, and a substituent which Ar1 may have is selected from the group consisting of a linear or branched alkyl group having 1 to 15 carbon atoms, a cycloalkyl group having 3 to 15 ring carbon atoms, a trialkylsilyl group having linear or branched alkyl groups each having 1 to 15 carbon atoms, a triarylsilyl group having aryl groups each having 6 to 25 ring carbon atoms, an alkylarylsilyl group having a linear or branched alkyl group having 1 to 15 carbon atoms and an aryl group having 6 to 25 ring carbon atoms, an aryl group having 6 to 25 ring carbon atoms, a halogen atom, and a cyano group;
a represents an integer of 0 to 3, and b, c, and d each independently represent an integer of 0 to 4; and
R1 to R4 each independently represent a linear or branched alkyl group having 1 to 15 carbon atoms, a cycloalkyl group having 3 to 15 ring carbon atoms, a trialkylsilyl group having linear or branched alkyl groups each having 1 to 15 carbon atoms, a triarylsilyl group having aryl groups each having 6 to 25 ring carbon atoms, an alkylarylsilyl group having a linear or branched alkyl group having 1 to 15 carbon atoms and an aryl group having 6 to 25 ring carbon atoms, an aryl group having 6 to 25 ring carbon atoms, a halogen atom, or a cyano group, and a plurality of R1's to R4's adjacent to each other may be bonded to each other to form a saturated or unsaturated, divalent group that forms a ring.

US Pat. No. 10,246,435

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

FORMA Therapeutics, Inc.,...

1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
X1 is C, S, or S(O);
Y1 is N or CH;
Y2 is N or CR5;
Y3 is N or CR6;
Y4 is N or CR7;
R1 is —OH;
R2 is (C1-C6) alkyl, or (C6-C14) aryl, wherein the alkyl or aryl are optionally substituted with one to three R8;
R4 and R4? are independently H;
R5 is H;
R6 is H, (C1-C6) alkyl, (C1-C6) alkoxy, halogen, —NH2, —NHC(O)(C1-C6) alkyl, (C6-C14) aryl, wherein the alkyl or aryl are optionally substituted with one to three R13;
R7 is H, (C1-C6) alkyl, (C6-C14) aryl, or —O—(C6-C14) aryl, wherein the alkyl or aryl are optionally substituted with one to three R14;
each R8 is independently (C1-C6) alkyl, halogen, or (C0-C4)-alkylene-(C6-C14) aryl, wherein the alkyl or aryl are optionally substituted with one to three R9;
or two R8 together when on adjacent atoms form a (C3-C8) cycloalkyl optionally substituted with one to three R9;
each R9 is independently (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, halogen, —(C0-C3)-alkylene-(C6-C14) aryl, wherein alkyl or aryl are optionally substituted with one to three R19;
each R13 is independently (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, halogen, CN, —OH, —NH2, (C1-C6) alkylamino, di(C1-C6) alkylamino, 3- to 7-membered heterocycloalkyl comprising 1 to 3 heteroatoms selected from O, N, and S, wherein the alkyl and heterocycloalkyl are optionally substituted with one to three R15;
each R14 is independently (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, halogen, CN, —OH, —NH2, —C(O)(C1-C6) alkyl, —S(O)q(C1-C6) alkyl, (C1-C6) alkylamino, or di(C1-C6) alkylamino;
each R15 is independently (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, halogen, —C(O)(C1-C6) alkyl, —S(O)q(C1-C6) alkyl, —NH2, (C1-C6) alkylamino, di(C1-C6) alkylamino, —OH, or CN;
each R19 is independently at each occurrence (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, halogen, —OH, or CN;
m is 0;
n is 1;
q is independently at each occurrence 0, 1, or 2; and
provided that
(a) when R2 is optionally substituted (C1-C6) alkyl, R5 is H; and R7 is H; then R6 is not chloro;
(b) R5, R6, and R7 are not all simultaneously H; and
(c) the compound is further characterized by any one or more of the following:
i. at least one of Y1, Y2, Y3, or Y4 is N;
ii. at least one of R6 or R7 is an optionally substituted (C6-C14) aryl;
iii. R6 is (C1-C6) alkyl, —NHC(O)(C1-C6) alkyl, (C6-C14) aryl, wherein the alkyl or aryl of R6 is substituted with a R13 that is (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, halogen, CN, —OH, —NH2, (C1-C6) alkylamino, or di(C1-C6) alkylamino;
iv. R6 is (C1-C6) alkyl, —NHC(O)(C1-C6) alkyl, (C6-C14) aryl, wherein the alkyl or aryl of R6 is substituted with a R13 that is (C1-C6) alkyl or a 3- to 7-membered heterocycloalkyl comprising 1 to 3 heteroatoms selected from O, N, and S, wherein the heterocycloalkyl is substituted with one to three R15; or
v. R7 is H, (C1-C6) alkyl, (C6-C14) aryl, or —O—(C6-C14) aryl, wherein the alkyl or aryl of R7 is substituted with a R14 that is (C1-C6) alkoxy, (C1-C6) haloalkyl, (C1-C6) haloalkoxy, halogen, CN, —OH, —NH2—, —C(O)(C1-C6) alkyl, —S(O)q(C1-C6) alkyl, (C1-C6) alkylamino, or di(C1-C6) alkylamino.

US Pat. No. 10,246,433

ARYL AND HETEROARYL FUSED LACTAMS

Pfizer Inc., New York, N...

1. A compound of formula (II-A):
or a pharmaceutically acceptable salt thereof,
wherein:
R1 is C1-C4 alkyl or halo;
R2 is 5-12 membered heteroaryl, where said 5-12 membered heteroaryl is optionally substituted by 1 to 3 R32 groups;
R3 is H;
R4 is H or halo;
m is 0;
R5 is absent;
each R32 is independently selected from the group consisting of —Cl, —F, —OH, —CH3, —CH2CH3, —CF3, —CH2OH, —CH2OCH3, —OCH3, —OC2H5, —OCF3, —CN, —C(O)NH2, —C(O)NHCH3, —C(O)N(CH3)2, —NHC(O)CH3, —NH2, —NHCH3, —N(CH3)2, cyclopropyl, 4-6 membered heterocyclyl, phenyl and 5-6 membered heteroaryl, where said 4-6 membered heterocyclyl, phenyl or 5-6 membered heteroaryl are optionally substituted by 1 to 3 halo, C1-C4 alkyl or C1-C4 alkoxy, which are independently selected;
X and Z are independently C1-C4 alkyl; and
Y is H.

US Pat. No. 10,246,432

4-(3-CYANOPHENYL)-6-PYRIDINYLPYRIMIDINE MGLU5 MODULATORS

Heptares Therapeutics Lim...

1. A method for the treatment of a disorder, comprising administering an effective amount of a compound to a subject in need thereof, wherein the compound is selected from the group consisting of the compounds represented by the following formulae:
or a pharmaceutically acceptable salt thereof, wherein
R1 is halogen, optionally substituted C1-C3 alkyl, cyclopropyl, optionally substituted C1-C3 alkoxy, cyano, hydroxyl, nitro or NH2;
R2 is H or F;
R3 is H, halogen, optionally substituted C1-C3 alkyl, optionally substituted C1-C3 alkoxy or cyano;
R4 is H, halogen, optionally substituted C1-C3 alkyl, optionally substituted C1-C3 alkoxy, or cyano; and
n is 0-3,
wherein the disorder is migraine, dystonia, depression, anxiety or amyotrophic lateral sclerosis (ALS).

US Pat. No. 10,246,429

VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

AMGEN INC., Thousand Oak...

1. A compound of Formula Ior a stereoisomer, tautomer, hydrate, solvate or a pharmaceutically acceptable salt thereof, whereinA4 is CR4 or N;
A5 is CR5 or N;
A6 is CR6 or N;
A7 is CR7 or N, provided that no more than two of A4, A5, A6, and A7 are N;
each of Ra and Rb, independently, is H, F, Cl, C1-6-alkyl, C2-4-alkenyl, C2-4-alkynyl, CN, —CH2OC1-6-alkyl, —OC1-6-alkyl, —S(O)oC1-6-alkyl, —NHC1-6-alkyl or —C(O)C1-6-alkyl, wherein each of the C1-6-alkyl, C2-4-alkenyl, C2-4-alkynyl, and C1-6-alkyl portion of —CH2OC1-6-alkyl, —OC1-6-alkyl, —S(O)oC1-6-alkyl, —NHC1-6-alkyl, and —C(O)C1-6-alkyl are optionally substituted with 1-4 substituents independently selected from F, oxo, or OH;
R1 is H, F, Cl, C1-6-alkyl, C2-4-alkenyl, C2-4-alkynyl, CN, —CH2OC1-6-alkyl, —OC1-6-alkyl, —S(O)oC1-6-alkyl, —NHC1-6-alkyl, —C(O)NH2, —CH?CHC(O)NH2, —CH?CHC(O)NHC1-6-alkyl, —CH?CHC(O)N(C1-6-alkyl)2, —CH?CHC(O)NHC1-6-alkyl-OC1-6-alkyl, —CH?CHC(O)-heterocyclyl, —CH?C(CH3)C(O)-heterocyclyl, —CH?CHC(O)2H, —CH?CHC(O)OC1-6-alkyl, —CH?CHCH2OH, C1-6-alkyl-C(O)NHC1-6-alkyl, C1-6-alkyl-C(O)N(C1-6-alkyl)2, —C(O)C1-6-alkyl, —C(O)C2-6-alkenyl, —C(O)OH, —C(O)OC1-6-alkyl, —C(O)NHC1-6-alkyl, —C(O)N(C1-6-alkyl)2, —C(O)NHC3-6-cycloalkyl, —C(O)NH-aryl, —C(O)NH-heterocyclyl, —C(O)NHOC1-6-alkyl, —C(O)N(C1-6-alkyl)OC1-6-alkyl, —C(O)-heterocyclyl, —CH2-heteroaryl, or heteroaryl, wherein the heterocyclyl groups of the —CH?CHC(O)-heterocyclyl, —CH?C(CH3)C(O)-heterocyclyl, —C(O)— heterocyclyl, and —C(O)NH-heterocyclyl groups are fully or partially saturated 3-, 4-, 5-, or 7-membered monocyclic rings or 6-, 7-, 8-, 9-, or 10-membered bicyclic rings that include 1 heteroatom selected from N, O, or S if the ring is a 3-membered ring, that include 1 or 2 heteroatoms independently selected from N, O, or S if the ring is a 4- or 5-membered ring, and include 1, 2, or 3 heteroatoms independently selected from N, O, or S if the ring is a 6-, 7-, 8-, 9-, or 10-membered ring, wherein the heteroaryl groups of the —CH2-heteroaryl and heteroaryl groups is a 5- or 6-membered ring that includes 1, 2, 3, or 4 heteroatoms independently selected from N, O, or S, wherein the aryl group of the —C(O)NH-aryl group is a phenyl or naphthyl group, wherein each of the C1-6-alkyl, C2-4-alkenyl, C2-4-alkynyl, and C1-6-alkyl and C2-6-alkenyl portions of —CH2OC1-6-alkyl, —OC1-6-alkyl, —S(O)oC1-6-alkyl, —NHC1-6-alkyl, C(O)C1-6-alkyl, —C(O)C2-6-alkenyl, —CH?CHC(O)NHC1-6-alkyl, —C(O)NHC1-6-alkyl, —C(O)N(C1-6-alkyl)2, and C1-6-alkyl-C(O)NHC1-6-alkyl groups is optionally substituted with 1-4 substituents independently selected from F, CN, oxo, or OH, and further wherein each of the heterocyclyl groups of the —CH?CHC(O)-heterocyclyl, —CH?C(CH3)C(O)-heterocyclyl, —C(O)heterocyclyl, and —C(O)NH-heterocyclyl groups is optionally substituted with 1-4 substituents independently selected from methyl, F, OH, oxo, —CN, OCH3, —CH2OC1-6-alkyl, —C(O)C1-6-alkyl, —C(O)OC1-6-alkyl, —CH2OH, —NH2, —NHC1-6-alkyl, —N(C1-6-alkyl)2, —CF3, phenyl, or —CH2—C3-6-cycloalkyl and further wherein each of the heteroaryl groups of the —CH2-heteroaryl and heteroaryl groups and the aryl group of the —C(O)NH-aryl group is optionally substituted with 1-3 substituents independently selected from halo, methyl, or OH;
R2 is H, F, Cl, C1-6-alkyl, C2-4-alkenyl, C2-4-alkynyl, CN, —CH2OC1-6-alkyl, —OC1-6-alkyl, —S(O)oC1-6-alkyl, —NHC1-6-alkyl, —C(O)NH2, —CH?CHC(O)NHC1-6-alkyl, —CH?CHC(O)2H, —CH?CHCH2OH, C1-6-alkyl-C(O)NHC1-6-alkyl, —C(O)C1-6-alkyl, or —C(O)C2-6-alkenyl, wherein each of the C1-6-alkyl, C2-4-alkenyl, C2-4-alkynyl, and C1-6-alkyl and C2-6-alkenyl portion of —CH2OC1-6-alkyl, —OC1-6-alkyl, —S(O)oC1-6-alkyl, —NHC1-6-alkyl, C(O)C1-6-alkyl, —C(O)C2-6-alkenyl, —CH?CHC(O)NHC1-6-alkyl, and C1-6-alkyl-C(O)NHC1-6-alkyl, is optionally substituted with 1-4 substituents independently selected from F, CN, oxo, or OH;
R3 is C1-4-alkyl, CH2OC1-4-alkyl, CH2OH, C1-4haloalkyl or cyclopropyl, wherein each of the C1-4-alkyl, CH2OC1-4-alkyl, C1-4-haloalkyl, and cyclopropyl is optionally substituted with 1-4 F atoms;
each of R4, R5, R6 and R7, independently, is H, halo, haloalkyl, haloalkoxyl, C1-4-alkyl, CN, OH, OC1-4-alkyl, S(O)oC1-4-alkyl, NHC1-4-alkyl, C(O)C1-4-alkyl, C(O)OC1-4-alkyl, or CH2OH;
R8 is selected from H, F, Cl, or C1-3-alkyl;
one of R9 and R10 is selected from F or H and the other of R9 and R10 is a fully or partially unsaturated 3-, 4-, 5-, 6-, or 7-membered monocyclic or 8-, 9-, or 10-membered bicyclic ring formed of carbon atoms, said ring optionally including 1-4 heteroatoms if monocyclic or 1-5 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein the ring is optionally substituted, independently, with 1-5 substituents of R11;
each R11, independently, is H, halo, haloalkyl, CN, OH, NO2, NH2, SF5, acetyl, —C(O)NHC1-6-alkyl, —OCH2C(O)NHC1-6-alkyl, —OCH2C(O)N(C1-6-alkyl)2, —OCH2CH2-pyrrolidinonyl, oxo, cyclopropylmethoxy, 2-propynyloxy, 2-butynyloxy, 2-pentyloxy, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-6-cycloalkyl, C1-6-alkylamino-, C1-6-dialkylamino-, C1-6-alkoxyl, C1-6-thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolyl, pyrrolidinyl, piperazinyl, oxetan-3-yl, imidazo-pyridinyl, dioxolyl, or —OCH2-heteroaryl, wherein the heteroaryl group of the —OCH2-heteroaryl group is a 5- or 6-membered ring that includes 1, 2, 3, or 4 heteroatoms selected from N, O, or S, and further wherein each of the cyclopropylmethoxy, 2-propynyloxy, 2-butynyloxy, 2-pentyloxy, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-6-cycloalkyl, C1-6-alkylamino-, C1-6-dialkylamino-, C1-6-alkoxyl, C1-6-thioalkoxyl, morpholinyl, pyrazolyl, isoxazolyl, dihydropyranyl, pyrrolidinyl, oxetan-3-yl, dioxolyl, or —OCH2-heteroaryl is optionally substituted independently with 1-5 substituents of F, Cl, Br, CN, NO2, NH2, OH, oxo, CF3, CHF2, CH2F, methyl, methoxy, ethyl, ethoxy, CH2CF3, CH2CHF2, propyl, propoxy, isopropyl, isopropoxy, cyclopropyl, butyl, butoxyl, cyclobutyl, isobutoxy, tert-butoxy, isobutyl, sec-butyl, tert-butyl, trimethylsilyl, cyclopentyl, cyclohexyl, C1-3alkylamino-, C1-3dialkylamino, C1-3thioalkoxyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, thienyl, furyl, pyrrolyl, tetrahydropyranyl, pyrrolidinyl, or oxetan-3yl; and
the subscript o is selected from 0, 1, or 2.

US Pat. No. 10,246,423

PROCESS FOR PREPARING STATIN PRECURSOR

Centrient Pharmaceuticals...

1. A process for preparing the compound of formula (IV), the process comprising the steps of:(a) providing a starting mixture comprising the compound of formula (II) and toluene

(b) a first reaction step, wherein the starting mixture is contacted with an organic sulfonyl halide and the resulting first reaction mixture is kept at a first temperature of below 110° C., thereby forming an intermediate mixture comprising the compound of formula (III)

wherein R is an organic group having from 1 to 15 carbons; and
(c) a second reaction step, wherein the intermediate mixture is contacted with N-methylmethane sulfonamide and the resulting second reaction mixture is kept at a second temperature, thereby forming a second mixture comprising the compound of formula (IV)

US Pat. No. 10,246,422

HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND IN COSMETICS

1. A heterocyclic compound of formula (I), or an enantiomer thereof, or a pharmaceutically acceptable salt thereof,
wherein,
Y is —CH2, —C(O), —C(CH3)2, or a spirocyclopropyl;
R1 is

R2, R3, and R6, which may be identical or different, are a hydrogen atom, F, or —CH3;
R4 is a hydrogen atom, an alkyl, an alkene, an alkyne, a cycloalkyl, a cycloalkene, an aralkyl, a heteroaralkyl, or one of the following:

R5 is a halogen; an alkyl; a cycloalkyl optionally substituted with R13, R14, and/or R15; an alkene; a cycloalkene; an alkyne; an ether; or one of the following:

with Het representing 1 to 3 nitrogen atoms among the 6 atoms of the aromatic ring, and these nitrogen atoms may, independently of one another, be substituted with an oxygen atom to form an N-oxide group;
R7 is

with n=0 or 1;
R8 and R9, which may be identical or different, are a hydrogen atom, F, or —CH3;
R10 is hydrogen atom, —OR11, —SR11, —NR11R12, —S(O)R11, —SO2R11, —OC(O)R11, —CO2R11, a halogen, —NO2, —CN, —C(O)NR11R12, —CF3, or —OCF3;
R11 and R12, which may be identical or different, are a hydrogen atom, a C1-C6 alkyl, CF3, or an ether;
R13, R14, and R15, which may be identical or different, are a hydrogen atom, a C1-C6 alkyl, a cycloalkyl, —OR16, —NR16R17, a halogen, —OCF3, —CF3, —CN, —CO2R16, —CONR16R17, —NO2, —OCH2OR16, —SR16, —S(O)R16, —SO2R16, or an ether;
A, B, and D, which may be identical or different, are a C, N, O, or S atom;
R16 and R17, which may be identical or different, are a hydrogen atom, a C1-C6 alkyl, or —C(O)R18;
Z is —CH2, O, or —NR18; and
R18 is a hydrogen atom or a C1-C3 alkyl.

US Pat. No. 10,246,418

CRYSTAL FORM OF LENVATINIB METHANESULFONATE SALT AND PREPARATION METHOD THEREOF

Crystal Pharmatech Co., L...

1. A crystalline Form M of compound (I) mesylate, wherein the X-ray powder diffraction pattern shows at least three characteristic peaks at 2theta values of 11.4°±0.2°, 6.1°±0.2°, 15.1°±0.2°, 12.5°±0.2°, 23.8°±0.2°, 21.8°±0.2°, 7.9°±0.2° and 20.2±0.2°.

US Pat. No. 10,246,417

PICOLINAMIDES AS FUNGICIDES

Dow AgroSciences LLC, In...

1. A composition for the control of a fungal pathogen including mixtures of at least one of the compounds of Formula I
wherein:
Q is

X is hydrogen or C(O)R5;
Y is hydrogen or C(O)R5;
Z is N or N+?O? and W is O or S;
R1 is hydrogen or alkyl, substituted with 0, 1 or multiple R8;
R2 is methyl;
R3 and R3? are independently chosen from C2-C6 alkyl, C3-C6 cycloalkyl, aryl or heteroaryl, each optionally substituted with 0, 1 or multiple R8; Alternatively, R3 and R3? may be taken together to form a 3-6 membered saturated or partially saturated carbocycle or heterocycle, optionally substituted with 0, 1 or multiple R8;
R4 is chosen from aryl or heteroaryl, each optionally substituted with 0, 1 or multiple R8;
R5 is chosen from alkoxy or benzyloxy, each optionally substituted with 0, 1, or multiple R8;
R6 is chosen from hydrogen, alkoxy, or halo, each optionally substituted with 0, 1, or multiple R8;
R7 is chosen from hydrogen, —C(O)R9, or —CH2OC(O)R9;
R8 is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkynyl, alkoxy, cyano, or heterocyclyl, each optionally substituted with 0, 1, or multiple R10;
R9 is chosen from alkyl, alkoxy, or aryl, each optionally substituted with 0, 1, or multiple R8;
R10 is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkoxy, or heterocyclyl;
R11 is chosen from hydrogen or alkyl, each substituted with 0, 1 or multiple R8; and
a phytologically acceptable carrier material.

US Pat. No. 10,246,415

PROCESS FOR PREPARING CARBAZOLES

Dow Global Technologies L...

1. A process for preparing a carbazole comprising:(a) contacting a compound represented by formula (1) below
wherein Cl is a chlorine atom; X is selected from the group consisting of bromo, iodo, triflate (trifluoromethanesulfonate), mesylate (methanesulfonate), arenesulfonates; R1-R4 are selected from the group consisting of hydrogen, alkyls, fluoroalkyls, aryls, heteroaryls, alkoxys, tertiary amines, fluoro, nitrile (CN), nitro (NO2), and trialkyl(aryl)silyl; and R1-R4 are never the same as X with diboron reagents in the presence of PdCl2(dppf) to form a dichlorobiaryl represented by formula (2);
and (b) contacting the 2,2?-dichlorobiaryl represented by formula (2) with a H2N—Y compound, wherein Y is selected from the group consisting of H, —COOR, —C(O)R, SiR3, SiAr3, CH2Ar, Na, Li, and 2-pyrimidyl, wherein Ar is a phenyl group and R is selected from the group consisting of alkyls, aryls, heteroaryls, and alkoxys in the presence of palladium containing catalytic components;
thereby forming the carbazole represented by formula (3) below

US Pat. No. 10,246,413

SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS

1. A compound of the general formula (I):
wherein:
X represents —CH2CH2;
Y represents —O—;
Z represents a covalent bond;
R* represents —R**, —CH2—R**, —CH2—CH?CH2, -cyclo-C6H11, or -cyclo-C5H9;
R** represents

R? and R? represent independently of each other —CH3, —C2H5, —CH(CH3)2, —CH2CH?CH2, -cyclo-C3H5, or —C(CH3)3;
RA represents:

RB represents: —R26,

RC represents: —R27,

RD represents: —R28,

R1-R22, R18?-R22?, R26-R39 represent independently of each other —H, —OH, —OCH3, —OC2H5, —OC3H7, —O-cyclo-C3H5, —OCH(CH3)2, —OC(CH3)3, —OC4H9, —OCH2—COOH, —OPh, —OCH2-Ph, —OCPh3, —CH2—OH, —C2H4—OH, —C3H6—OH, —CH(OH)—CH2—OH, —CH2—OCH3, —C2H4—OCH3, —C4H8—OCH3, —C3H6—OCH3, —CH2—OC2H5, —C2H4—OC2H5, —C3H6—OC2H5, —C4H8—OC2H5, —CH2—OC3H7, —C2H4—OC3H7, —C3H6—OC3H7, —CH2—O-cyclo-C3H5, —C2H4—O-cyclo-C3H5, —C3H6—O-cyclo-C3H5, —C4H8—O-cyclo-C3H5, —CH2—OCH(CH3)2, —C2H4—OCH(CH3)2, —C3H6—OCH(CH3)2, —C4H8—OCH(CH3)2, —CH2—OC(CH3)3, —C2H4—OC(CH3)3, —C3H6—OC(CH3)3, —C4H8—OC(CH3)3, —CH2—OC4H9, —C2H4—OC4H9, —C3H6—OC4H9, —C4H8—OC4H9, —CH2—OPh, —C2H4—OPh, —C3H6—OPh, —C4H8—OPh, —CH2—OCH2-Ph, —C2H4—OCH2-Ph, —C3H6—OCH2-Ph, —C4H8—OCH2-Ph, —SH, —SCH3, —SC2H5, —SC3H7, —S-cyclo-C3H5, —SCH(CH3)2, —SC(CH3)3, —NO2, —F, —Cl, —Br, —I, —P(O)(OH)2, —P(O)(OCH3)2, —P(O)(OC2H5)2, —P(O)(OCH(CH3)2)2, —C(OH)[P(O)(OH)2]2, —Si(CH3)2(C(CH3)3), —Si(C2H5)3, —Si(CH3)3, —N3, —CN, —OCN, —NCO, —SCN, —NCS, —CHO, —COCH3, —COC2H5, —COC3H7, —CO-cyclo-C3H5, —COCH(CH3)2, —COC(CH3)3, —COOH, —COCN, —COOCH3, —COOC2H5, —COOC3H7, —COO-cyclo-C3H5, —COOCH(CH3)2, —COOC(CH3)3, —OOC—CH3, —OOC—C2H5, —OOC—C3H7, —OOC-cyclo-C3H5, —OOC—CH(CH3)2, —OOC—C(CH3)3, —CONH2, —CH2—CONH2, —CONHCH3, —CONHC2H5, —CONHC3H7, —CONH-cyclo-C3H5, —CONH[CH(CH3)2], —CONH[C(CH3)3], —CON(CH3)2, —CON(C2H5)2, —CON(C3H7)2, —CON(cyclo-C3H5)2, —CON[CH(CH3)2]2, —CON[C(CH3)3]2, —NHCOCH3, —NHCOC2H5, —NHCOC3H7, —NHCO-cyclo-C3H5, —NHCO—CH(CH3)2, —NHCO—C(CH3)3, —NHCO—OCH3, —NHCO—OC2H5, —NHCO—OC3H7, —NHCO—O-cyclo-C3H5, —NHCO—OCH(CH3)2, —NHCO—OC(CH3)3, —NH2, —NHCH3, —NHC2H5, —NHC3H7, —NH-cyclo-C3H5, —NHCH(CH3)2, —NHC(CH3)3, —N(CH3)2, —N(C2H5)2, —N(C3H7)2, —N(cyclo-C3H5)2, —N[CH(CH3)2]2, —N[C(CH3)3]2, —SOCH3, —SOC2H5, —SOC3H7, —SO-cyclo-C3H5, —SOCH(CH3)2, —SOC(CH3)3, —SO2CH3, —SO2C2H5, —SO2C3H7, —SO2-cyclo-C3H5, —SO2CH(CH3)2, —SO2C(CH3)3, —SO3H, —SO3CH3, —SO3C2H5, —SO3C3H7, —SO3-cyclo-C3H5, —SO3CH(CH3)2, —SO3C(CH3)3, —SO2NH2, —SO2NHCH3, —SO2NHC2H5, —SO2NHC3H7, —SO2NH-cyclo-C3H5, —SO2NHCH(CH3)2, —SO2NHC(CH3)3, —SO2N(CH3)2, —SO2N(C2H5)2, —SO2N(C3H7)2, —SO2N(cyclo-C3H5)2, —SO2N[CH(CH3)2]2, —SO2N[C(CH3)3]2, —O—S(?O)CH3, —O—S(?O)C2H5, —O—S(?O)C3H7, —O—S(?O)-cyclo-C3H5, —O—S(?O)CH(CH3)2, —O—S(?O)C(CH3)3, —S(?O)(?NH)CH3, —S(?O)(?NH)C2H5, —S(?O)(?NH)C3H7, —S(?O)(?NH)-cyclo-C3H5, —S(?O)(?NH)CH(CH3)2, —S(?O)(?NH)C(CH3)3, —NH—SO2—CH3, —NH—SO2—C2H5, —NH—SO2—C3H7, —NH—SO2-cyclo-C3H5, —NH—SO2—CH(CH3)2, —NH—SO2—C(CH3)3, —O—SO2—CH3, —O—SO2—C2H5, —O—SO2—C3H7, —O—SO2-cyclo-C3H5, —O—SO2—CH(CH3)2, —O—SO2—C(CH3)3, —OCF3, —CH2—OCF3, —C2H4—OCF3, —C3H6—OCF3, —OC2F5, —CH2—OC2F5, —C2H4—OC2F5, —C3H6—OC2F5, —O—COOCH3, —O—COOC2H5, —O—COOC3H7, —O—COO-cyclo-C3H5, —O—COOCH(CH3)2, —O—COOC(CH3)3, —NH—CO—NH2, —NH—CO—NHCH3, —NH—CO—NHC2H5, —NH—CS—N(C3H7)2, —NH—CO—NHC3H7, —NH—CO—N(C3H7)2, —NH—CO—NH[CH(CH3)2], —NH—CO—NH[C(CH3)3], —NH—CO—N(CH3)2, —NH—CO—N(C2H5)2, —NH—CO—NH-cyclo-C3H5, —NH—CO—N(cyclo-C3H5)2, —NH—CO—N[CH(CH3)2]2, —NH—CS—N(C2H5)2, —NH—CO—N[C(CH3)3]2, —NH—CS—NH2, —NH—CS—NHCH3, —NH—CS—N(CH3)2, —NH—CS—NHC2H5, —NH—CS—NHC3H7, —NH—CS—NH-cyclo-C3H5, —NH—CS—NH[CH(CH3)2], —NH—CS—NH[C(CH3)3], —NH—CS—N(cyclo-C3H5)2, —NH—CS—N[CH(CH3)2]2, —NH—CS—N[C(CH3)3]2, —NH—C(?NH)—NH2, —NH—C(?NH)—NHCH3, —NH—C(?NH)—NHC2H5, —NH—C(?NH)—NHC3H7, —O—CO—NH-cyclo-C3H5, —NH—C(?NH)—NH-cyclo-C3H5, —NH—C(?NH)—NH[CH(CH3)2]—O—CO—NH[CH(CH3)2], —NH—C(?NH)—NH[C(CH3)3], —NH—C(?NH)—N(CH3)2, —NH—C(?NH)—N(C2H5)2, —NH—C(?NH)—N(C3H7)2, —NH—C(?NH)—N(cyclo-C3H5)2, —O—CO—NHC3H7, —NH—C(?NH)—N[CH(CH3)2]2, —NH—C(?NH)—N[C(CH3)3]2, —O—CO—NH2, —O—CO—NHCH3, —O—CO—NHC2H5, —O—CO—NH[C(CH3)3], —O—CO—N(CH3)2, —O—CO—N(C2H5)2, —O—CO—N(C3H7)2, —O—CO—N(cyclo-C3H5)2, —O—CO—N[CH(CH3)2]2, —O—CO—N[C(CH3)3]2, —O—CO—OCH3, —O—CO—OC2H5, —O—CO—OC3H7, —O—CO—O-cyclo-C3H5, —O—CO—OCH(CH3)2, —O—CO—OC(CH3)3, —CH2F, —CHF2, —CF3, —CH2C1, —CH2Br, —CH2I, —CH2—CH2F, —CH2—CHF2, —CH2—CF3, —CH2—CH2C1, —CH2—CH2Br, —CH2—CH2I, -cyclo-C5H9, -cyclo-C6H11, —CH2-cyclo-C6H11, —CH2—CH2-cyclo-C6H11, -cyclo-C7H13, -cyclo-C8H15, -Ph, —CH2-Ph, —CH2—CH2-Ph, —CH?CH-Ph, —CPh3, —CH3, —C2H5, —C3H7, —CH(CH3)2, —C4H9, —CH2—CH(CH3)2, —CH(CH3)—C2H5, —C(CH3)3, —C5H11, —CH(CH3)—C3H7, —CH2—CH(CH3)—C2H5, —CH(CH3)—CH(CH3)2, —C(CH3)2—C2H5, —CH2—C(CH3)3, —CH(C2H5)2, —C2H4—CH(CH3)2, —C6H13, —C7H15, —C8H17, —C3H6—CH(CH3)2, —C2H4—CH(CH3)—C2H5, —CH(CH3)—C4H9, —CH2—CH(CH3)—C3H7, —CH(CH3)—CH2—CH(CH3)2, —CH(CH3)—CH(CH3)—C2H5, —CH2—CH(CH3)—CH(CH3)2, —CH2—C(CH3)2—C2H5, —C(CH3)2—C3H7, —C(CH3)2—CH(CH3)2, —C2H4—C(CH3)3, —CH(CH3)—C(CH3)3, —CH?CH2, —CH2—CH?CH2, —C(CH3)?CH2, —CH?CH—CH3, —C2H4—CH?CH2, —CH2—CH?CH—CH3, —CH?CH—C2H5, —CH2—C(CH3)?CH2, —CH(CH3)—CH?CH, —CH?C(CH3)2, —C(CH3)?CH—CH3, —CH?CH—CH?CH2, —C3H6—CH?CH2, —C2H4—CH?CH—CH3, —CH2—CH?CH—C2H5, —CH?CH—C3H7, —CH2—CH?CH—CH?CH2, —CH?CH—CH?CH—CH3, —CH?CH—CH2—CH?CH2, —C(CH3)?CH—CH?CH2, —CH?C(CH3)—CH?CH2, —CH?CH—C(CH3)?CH2, —C2H4—C(CH3)?CH2, —CH2—CH(CH3)—CH?CH2, —CH(CH3)—CH2—CH?CH2, —CH2—CH?C(CH3)2, —CH2—C(CH3)?CH—CH3, —CH(CH3)—CH?CH—CH3, —C(CH3)?C(CH3)2, —C(CH3)2—CH?CH2, —CH(CH3)—C(CH3)?CH2, —C(CH3)?CH—CH?CH2, —CH?C(CH3)—CH?CH2, —CH?CH—C(CH3)?CH2, —C4H8—CH?CH2, —C3H6—CH?CH—CH3, —C2H4—CH?CH—C2H5, —CH2—CH?CH—C3H7, —CH?CH—C4H9, —C3H6—C(CH3)?CH2, —C2H4—CH(CH3)—CH?CH2, —CH2—CH(CH3)—CH2—CH?CH2, —C2H4—CH?C(CH3)2, —CH(CH3)—C2H4—CH?CH2, —C2H4—C(CH3)?CH—CH3, —CH2—CH(CH3)—CH?CH—CH3, —CH(CH3)—CH2—CH?CH—CH3, —CH2—CH?CH—CH(CH3)2, —CH2—CH?C(CH3)—C2H5, —CH2—C(CH3)?CH—C2H5, —CH(CH3)—CH?CH—C2H5, —CH?CH—CH2—CH(CH3)2, —CH?CH—CH(CH3)—C2H5, —CH?C(CH3)—C3H7, —C(CH3)?CH—C3H7, —CH2—CH(CH3)—C(CH3)?CH2, —C[C(CH3)3]?CH2, —CH(CH3)—CH2—C(CH3)?CH2, —CH(CH3)—CH(CH3)—CH?CH2, —CH?CH—C2H4—CH?CH2, —CH2—C(CH3)2—CH?CH2, —C(CH3)2—CH2—CH?CH2, —CH2—C(CH3)?C(CH3)2, —CH(CH3)—CH?C(CH3)2, —C(CH3)2—CH?CH—CH3, —CH?CH—CH2—CH?CH—CH3, —CH(CH3)—C(CH3)?CH—CH3, —CH?C(CH3)—CH(CH3)2, —C(CH3)?CH—CH(CH3)2, —C(CH3)?C(CH3)—C2H5, —CH?CH—C(CH3)3, —C(CH3)2—C(CH3)?CH2, —CH(C2H5)—C(CH3)?CH2, —C(CH3)(C2H5)—CH?CH2, —CH(CH3)—C(C2H5)?CH2, —CH2—C(C3H7)?CH2, —CH2—C(C2H5)?CH—CH3, —CH(C2H5)—CH?CH—CH3, —C(C4H9)?CH2, —C(C3H7)?CH—CH3, —C(C2H5)?CH—C2H5, —C(C2H5)?C(CH3)2, —C[CH(CH3)(C2H5)]?CH2, —C[CH2—CH(CH3)2]?CH2, —C2H4—CH?CH—CH?CH2, —CH2—CH?CH—CH2—CH?CH2, —C3H6—C?C—CH3, —CH2—CH?CH—CH?CH—CH3, —CH?CH—CH?CH—C2H5, —CH2—CH?CH—C(CH3)?CH2, —CH2—CH?C(CH3)—CH?CH2, —CH2—C(CH3)?CH—CH?CH2, —CH(CH3)—CH2—C?CH, —CH(CH3)—CH?CH—CH?CH2, —CH?CH—CH2—C(CH3)?CH2, —CH(CH3)—C?C—CH3, —CH?CH—CH(CH3)—CH?CH2, —CH?C(CH3)—CH2—CH?CH2, —C2H4—CH(CH3)—C?CH, —C(CH3)?CH—CH2—CH?CH2, —CH?CH—CH?C(CH3)2, —CH2—CH(CH3)—CH2—C?CH, —CH?CH—C(CH3)?CH—CH3, —CH?C(CH3)—CH?CH—CH3, —CH2—CH(CH3)—C?CH, —C(CH3)?CH—CH?CH—CH3, —CH?C(CH3)—C(CH3)?CH2, —C(CH3)?CH—C(CH3)?CH2, —C(CH3)?C(CH3)—CH?CH2, —CH?CH—CH?CH—CH?CH2, —C?CH, —C?C—CH3, —CH2—C?CH, —C2H4—C?CH, —CH2—C?C—CH3, —C?C—C2H5, —C3H6—C?CH, —C2H4—C?C—CH3, —CH2—C?C—C2H5, —C?C—C3H7, —CH(CH3)—C?CH, —C4H8—C?CH, —C2H4—C?C—C2H5, —CH2—C?C—C3H7, —C?C—C4H9, —C?C—C(CH3)3, —CH(CH3)—C2H4—C?CH, —CH2—CH(CH3)—C?C—CH3, —CH(CH3)—CH2—C?C—CH3, —CH(CH3)—C?C—C2H5, —CH2—C?C—CH(CH3)2, —C?C—CH(CH3)—C2H5, —C?C—CH2—CH(CH3)2, —CH(C2H5)—C?C—CH3, —C(CH3)2—C?C—CH3, —CH(C2H5)—CH2—C?CH, —CH2—CH(C2H5)—C?CH, —C(CH3)2—CH2—C?CH, —CH2—C(CH3)2—C?CH, —CH(CH3)—CH(CH3)—C?CH, —CH(C3H7)—C?CH, —C(CH3)(C2H5)—C?CH, —CH2—CH(C?CH)2, —C?C—C?CH, —CH2—C?C—C?CH, —C?C—C?C—CH3, —CH(C?CH)2, —C2H4—C?C—C?CH, —CH2—C?C—CH2—C?CH, —C?C—C2H4—C?CH, —CH2—C?C—C?C—CH3, —C?C—CH2—C?C—CH3, —C?C—C?C—C2H5, —C(C?CH)2—CH3, —C?C—CH(CH3)—C?CH, —CH(CH3)—C?C—C?CH, —CH(C?CH)—CH2—C?CH, —CH(C?CH)—C?C—CH3,

R18 and R18? or R19 and R19? or R20 and R20? or R21 and R21? or R22 and R22? form together ?O,
or ?CR23?R24?, wherein R23? and R24? represent independently of each other —H, —CH3, —C2H5, —CF3, —CH2CF3, or —C2F5;R23-R25 represent independently of each other —H, —CH2—OCH3, —C2H4—OCH3, —C3H6—OCH3, —CH2—OC2H5, —C2H4—OC2H5, —C3H6—OC2H5, —CH2—OC3H7, —C2H4—OC3H7, —C3H6—OC3H7, —CH2—O-cyclo-C3H5, —C2H4—O-cyclo-C3H5, —C3H6—O-cyclo-C3H5, —CH2—OCH(CH3)2, —C2H4—OCH(CH3)2, —C3H6—OCH(CH3)2, —CH2—OC(CH3)3, —C2H4—OC(CH3)3, —C3H6—OC(CH3)3, —CH2—OC4H9, —C2H4—OC4H9, —C3H6—OC4H9, —CH2—OPh, —C2H4—OPh, —C3H6—OPh, —CH2—OCH2-Ph, —C2H4—OCH2-Ph, —C3H6—OCH2-Ph, —CH2F, —CHF2, —CF3, —CH2Cl, —CH2Br, —CH2I, —CH2—CH2F, —CH2—CHF2, —CH2—CF3, —CH2—CH2Cl, —CH2—CH2Br, —CH2—CH2I, -cyclo-C8H15, -Ph, —CH2-Ph, —CH2—CH2-Ph, —CH?CH-Ph, —CPh3, —CH3, —C2H5, —C3H7, —CH(CH3)2, —C4H9, —CH2—CH(CH3)2, —CH(CH3)—C2H5, —C(CH3)3, —C5H11, —CH(CH3)—C3H7, —CH2—CH(CH3)—C2H5, —CH(CH3)—CH(CH3)2, —C(CH3)2—C2H5, —CH2—C(CH3)3, —CH(C2H5)2, —C2H4—CH(CH3)2, —C6H13, —C7H15, —C8H17, —C3H6—CH(CH3)2, —C2H4—CH(CH3)—C2H5, —CH(CH3)—C4H9, —CH2—CH(CH3)—C3H7, —CH(CH3)—CH2—CH(CH3)2, —CH(CH3)—CH(CH3)—C2H5, —CH2—CH(CH3)—CH(CH3)2, —CH2—C(CH3)2—C2H5, —C(CH3)2—C3H7, —C(CH3)2—CH(CH3)2, —C2H4—C(CH3)3, —CH(CH3)—C(CH3)3, —CH?CH2, —CH2—CH?CH2, —C(CH3)?CH2, —CH?CH—CH3, —C2H4—CH?CH2, —CH2—CH?CH—CH3, —CH?CH—C2H5, —CH2—C(CH3)?CH2, —CH(CH3)—CH?CH, —CH?C(CH3)2, —C(CH3)?CH—CH3, —CH?CH—CH?CH2, —C3H6—CH?CH2, —C2H4—CH?CH—CH3, —CH2—CH?CH—C2H5, —CH?CH—C3H7, —CH2—CH?CH—CH?CH2, —CH?CH—CH?CH—CH3, —CH?CH—CH2—CH?CH2, —C(CH3)?CH—CH?CH2, —CH?C(CH3)—CH?CH2, —CH?CH—C(CH3)?CH2, —C2H4—C(CH3)?CH2, —CH2—CH(CH3)—CH?CH2, —CH(CH3)—CH2—CH?CH2, —CH2—CH?C(CH3)2, —CH2—C(CH3)?CH—CH3, —CH(CH3)—CH?CH—CH3, —CH?CH—CH(CH3)2, —CH?C(CH3)—C2H5, —C(CH3)?CH—C2H5, —C(CH3)?C(CH3)2, —C(CH3)2—CH?CH2, —CH(CH3)—C(CH3)?CH2, —C(CH3)?CH—CH?CH2, —CH?C(CH3)—CH?CH2, —CH?CH—C(CH3)?CH2, —C4H8—CH?CH2, —C3H6—CH?CH—CH3, —C2H4—CH?CH—C2H5, —CH2—CH?CH—C3H7, —CH?CH—C4H9, —C3H6—C(CH3)?CH2, —C2H4—CH(CH3)—CH?CH2, —CH2—CH(CH3)—CH2—CH?CH2, —C2H4—CH?C(CH3)2, —CH(CH3)—C2H4—CH?CH2, —C2H4—C(CH3)?CH—CH3, —CH2—CH(CH3)—CH?CH—CH3, —CH(CH3)—CH2—CH?CH—CH3, —CH2—CH?CH—CH(CH3)2, —CH2—CH?C(CH3)—C2H5, —CH2—C(CH3)?CH—C2H5, —CH(CH3)—CH?CH—C2H5, —CH?CH—CH2—CH(CH3)2, —CH?CH—CH(CH3)—C2H5, —CH?C(CH3)—C3H7, —C(CH3)?CH—C3H7, —CH2—CH(CH3)—C(CH3)?CH2, —C[C(CH3)3]?CH2, —CH(CH3)—CH2—C(CH3)?CH2, —CH(CH3)—CH(CH3)—CH?CH2, —CH?CH—C2H4—CH?CH2, —CH2—C(CH3)2—CH?CH2, —C(CH3)2—CH2—CH?CH2, —CH2—C(CH3)?C(CH3)2, —CH(CH3)—CH?C(CH3)2, —C(CH3)2—CH?CH—CH3, —CH?CH—CH2—CH?CH—CH3, —CH(CH3)—C(CH3)?CH—CH3, —CH?C(CH3)—CH(CH3)2, —C(CH3)?CH—CH(CH3)2, —C(CH3)?C(CH3)—C2H5, —CH?CH—C(CH3)3, —C(CH3)2—C(CH3)?CH2, —CH(C2H5)—C(CH3)?CH2, —C(CH3)(C2H5)—CH?CH2, —CH(CH3)—C(C2H5)?CH2, —CH2—C(C3H7)?CH2, —CH2—C(C2H5)?CH—CH3, —CH(C2H5)—CH?CH—CH3, —C(C4H9)?CH2, —C(C3H7)?CH—CH3, —C(C2H5)?CH—C2H5, —C(C2H5)?C(CH3)2, —C[CH(CH3)(C2H5)]?CH2, —C[CH2—CH(CH3)2]?CH2, —CH2—CH?CH—CH?CH—CH3, —CH?CH—CH?CH—C2H5, —CH2—CH?CH—C(CH3)?CH2, —CH2—CH?C(CH3)—CH?CH2, —CH2—C(CH3)?CH—CH?CH2, —CH(CH3)—CH2—C?CH, —CH(CH3)—CH?CH—CH?CH2, —CH?CH—CH2—C(CH3)?CH2, —CH(CH3)—C?C—CH3, —CH?CH—CH(CH3)—CH?CH2, —CH?C(CH3)—CH2—CH?CH2, —C2H4—CH(CH3)—C?CH, —C(CH3)?CH—CH2—CH?CH2, —CH?CH—CH?C(CH3)2, —CH2—CH(CH3)—CH2—C?CH, —CH?CH—C(CH3)?CH—CH3, —CH?C(CH3)—CH?CH—CH3, —CH2—CH(CH3)—C?CH, —C(CH3)?CH—CH?CH—CH3, —CH?C(CH3)—C(CH3)?CH2, —C(CH3)?CH—C(CH3)?CH2, —C(CH3)?C(CH3)—CH?CH2, —CH?CH—CH?CH—CH?CH2, —C?CH, —C?C—CH3, —CH2—C?CH, —C2H4—C?CH, —CH2—C?C—CH3, —C?C—C2H5, —C3H6—C?CH, —C2H4—C?C—CH3, —CH2—C?C—C2H5, —C?C—C3H7, —CH(CH3)—C?CH, —C4H8—C?CH, —C2H4—C?C—C2H5, —CH2—C?C—C3H7, —C?C—C4H9, —C?C—C(CH3)3, —CH(CH3)—C2H4—C?CH, —CH2—CH(CH3)—C?C—CH3, —CH(CH3)—CH2—C?C—CH3, —CH(CH3)—C?C—C2H5, —CH2—C?C—CH(CH3)2, —C?C—CH(CH3)—C2H5, —C?C—CH2—CH(CH3)2, —CH(C2H5)—C?C—CH3, —C(CH3)2—C?C—CH3, —CH(C2H5)—CH2—C?CH, —CH2—CH(C2H5)—C?CH, —C(CH3)2—CH2—C?CH, —CH2—C(CH3)2—C?CH, —CH(CH3)—CH(CH3)—C?CH, —CH(C3H7)—C?CH, —C(CH3)(C2H5)—C?CH, —CH2—CH(C?CH)2, —C?C—C?CH, —CH2—C?C—C?CH, —C?C—C?C—CH3, —CH(C?CH)2, —C2H4—C?C—C?CH, —CH2—C?C—CH2—C?CH, —C?C—C2H4—C?CH, —CH2—C?C—C?C—CH3, —C?C—CH2—C?C—CH3, —C?C—C?C—C2H5, —C(C?CH)2—CH3, —C?C—CH(CH3)—C?CH, —CH(CH3)—C?C—C?CH, —CH(C?CH)—CH2—C?CH, or —CH(C?CH)—C?C—CH3;
RN represents —H, —CH2—OCH3, —C2H4—OCH3, —C3H6—OCH3, —CH2—OC2H5, —C2H4—OC2H5, —C3H6—OC2H5, —CH2—OC3H7, —C2H4—OC3H7, —C3H6—OC3H7, —CH2—O-cyclo-C3H5, —C2H4—O-cyclo-C3H5, —C3H6—O-cyclo-C3H5, —CH2—OCH(CH3)2, —C2H4—OCH(CH3)2, —C3H6—OCH(CH3)2, —CH2—OC(CH3)3, —C2H4—OC(CH3)3, —C3H6—OC(CH3)3, —CH2—OC4H9, —C2H4—OC4H9, —C3H6—OC4H9, —CH2—OPh, —C2H4—OPh, —C3H6—OPh, —CH2—OCH2-Ph, —C2H4—OCH2-Ph, —C3H6—OCH2-Ph, —CHO, —COCH3, —COC2H5, —COC3H7, —CO-cyclo-C3H5, —COCH(CH3)2, —COC(CH3)3, —COCN, —COOCH3, —COOC2H5, —COOC3H7, —COO-cyclo-C3H5, —COOCH(CH3)2, —COOC(CH3)3, —CONH2, —CONHCH3, —CONHC2H5, —CONHC3H7, —CONH-cyclo-C3H5, —CONH[CH(CH3)2], —CONH[C(CH3)3], —CON(CH3)2, —CON(C2H5)2, —CON(C3H7)2, —CON(cyclo-C3H5)2, —CON[CH(CH3)2]2, —CON[C(CH3)3]2, —SO2CH3, —SO2C2H5, —SO2C3H7, —SO2-cyclo-C3H5, —SO2CH(CH3)2, —SO2C(CH3)3, —CH2—OCF3, —C2H4—OCF3, —C3H6—OCF3, —OC2F5, —CH2—OC2F5, —C2H4—OC2F5, —C3H6—OC2F5, —CH2F, —CHF2, —CF3, —CH2Cl, —CH2Br, —CH2I, —CH2—CH2F, —CH2—CHF2, —CH2—CF3, —CH2—CH2Cl, —CH2—CH2Br, —CH2—CH2I, -cyclo-C8H15, -Ph, —CH2-Ph, —CH2—CH2-Ph, —CH?CH-Ph, —CPh3, —CH3, —C2H5, —C3H7, —CH(CH3)2, —C4H9, —CH2—CH(CH3)2, —CH(CH3)—C2H5, —C(CH3)3, —C5H11, —CH(CH3)—C3H7, —CH2—CH(CH3)—C2H5, —CH(CH3)—CH(CH3)2, —C(CH3)2—C2H5, —CH2—C(CH3)3, —CH(C2H5)2, —C2H4—CH(CH3)2, —C6H13, —C7H15, —C8H17, —C3H6—CH(CH3)2, —C2H4—CH(CH3)—C2H5, —CH(CH3)—C4H9, —CH2—CH(CH3)—C3H7, —CH(CH3)—CH2—CH(CH3)2, —CH(CH3)—CH(CH3)—C2H5, —CH2—CH(CH3)—CH(CH3)2, —CH2—C(CH3)2—C2H5, —C(CH3)2—C3H7, —C(CH3)2—CH(CH3)2, —C2H4—C(CH3)3, —CH(CH3)—C(CH3)3, —CH?CH2, —CH2—CH?CH2, —C(CH3)?CH2, —CH?CH—CH3, —C2H4—CH?CH2, —CH2—CH?CH—CH3, —CH?CH—C2H5, —CH2—C(CH3)?CH2, —CH(CH3)—CH?CH, —CH?C(CH3)2, —C(CH3)?CH—CH3, —CH?CH—CH?CH2, —C3H6—CH?CH2, —C2H4—CH?CH—CH3, —CH2—CH?CH—C2H5, —CH?CH—C3H7, —CH2—CH?CH—CH?CH2, —CH?CH—CH?CH—CH3, —CH?CH—CH2—CH?CH2, —C(CH3)?CH—CH?CH2, —CH?C(CH3)—CH?CH2, —CH?CH—C(CH3)?CH2, —C2H4—C(CH3)?CH2, —CH2—CH(CH3)—CH?CH2, —CH(CH3)—CH2—CH?CH2, —CH2—CH?C(CH3)2, —CH2—C(CH3)?CH—CH3, —CH(CH3)—CH?CH—CH3, —CH?CH—CH(CH3)2, —CH?C(CH3)—C2H5, —C(CH3)?CH—C2H5, —C(CH3)?C(CH3)2, —C(CH3)2—CH?CH2, —CH(CH3)—C(CH3)?CH2, —C(CH3)?CH—CH?CH2, —CH?C(CH3)—CH?CH2, —CH?CH—C(CH3)?CH2, —C4H8—CH?CH2, —C3H6—CH?CH—CH3, —C2H4—CH?CH—C2H5, —CH2—CH?CH—C3H7, —CH?CH—C4H9, —C3H6—C(CH3)?CH2, —C2H4—CH(CH3)—CH?CH2, —CH2—CH(CH3)—CH2—CH?CH2, —C2H4—CH?C(CH3)2, —CH(CH3)—C2H4—CH?CH2, —C2H4—C(CH3)?CH—CH3, —CH2—CH(CH3)—CH?CH—CH3, —CH(CH3)—CH2—CH?CH—CH3, —CH2—CH?CH—CH(CH3)2, —CH2—CH?C(CH3)—C2H5, —CH2—C(CH3)?CH—C2H5, —CH(CH3)—CH?CH—C2H5, —CH?CH—CH2—CH(CH3)2, —CH?CH—CH(CH3)—C2H5, —CH?C(CH3)—C3H7, —C(CH3)?CH—C3H7, —CH2—CH(CH3)—C(CH3)?CH2, —C[C(CH3)3]?CH2, —CH(CH3)—CH2—C(CH3)?CH2, —CH(CH3)—CH(CH3)—CH?CH2, —CH?CH—C2H4—CH?CH2, —CH2—C(CH3)2—CH?CH2, —C(CH3)2—CH2—CH?CH2, —CH2—C(CH3)?C(CH3)2, —CH(CH3)—CH?C(CH3)2, —C(CH3)2—CH?CH—CH3, —CH?CH—CH2—CH?CH—CH3, —CH(CH3)—C(CH3)?CH—CH3, —CH?C(CH3)—CH(CH3)2, —C(CH3)?CH—CH(CH3)2, —C(CH3)?C(CH3)—C2H5, —CH?CH—C(CH3)3, —C(CH3)2—C(CH3)?CH2, —CH(C2H5)—C(CH3)?CH2, —C(CH3)(C2H5)—CH?CH2, —CH(CH3)—C(C2H5)?CH2, —CH2—C(C3H7)?CH2, —CH2—C(C2H5)?CH—CH3, —CH(C2H5)—CH?CH—CH3, —C(C4H9)?CH2, —C(C3H7)?CH—CH3, —C(C2H5)?CH—C2H5, —C(C2H5)?C(CH3)2, —C[CH(CH3)(C2H5)]?CH2, —C[CH2—CH(CH3)2]?CH2, —C2H4—CH?CH—CH?CH2, —CH2—CH?CH—CH2—CH?CH2, —C3H6—C?C—CH3, —CH2—CH?CH—CH?CH—CH3, —CH?CH—CH?CH—C2H5, —CH2—CH?CH—C(CH3)?CH2, —CH2—CH?C(CH3)—CH?CH2, —CH2—C(CH3)?CH—CH?CH2, —CH(CH3)—CH2—C?CH, —CH(CH3)—CH?CH—CH?CH2, —CH?CH—CH2—C(CH3)?CH2, —CH(CH3)—C?C—CH3, —CH?CH—CH(CH3)—CH?CH2, —CH?C(CH3)—CH2—CH?CH2, —C2H4—CH(CH3)—C?CH, —C(CH3)?CH—CH2—CH?CH2, —CH?CH—CH?C(CH3)2, —CH2—CH(CH3)—CH2—C?CH, —CH?CH—C(CH3)?CH—CH3, —CH?C(CH3)—CH?CH—CH3, —CH2—CH(CH3)—C?CH, —C(CH3)?CH—CH?CH—CH3, —CH?C(CH3)—C(CH3)?CH2, —C(CH3)?CH—C(CH3)?CH2, —C(CH3)?C(CH3)—CH?CH2, —CH?CH—CH?CH—CH?CH2, —C?CH, —C?C—CH3, —CH2—C?CH, —C2H4—C?CH, —CH2—C?C—CH3, —C?C—C2H5, —C3H6—C?CH, —C2H4—C?C—H3, —CH2—C?C—C2H5, —C?C—C3H7, —CH(CH3)—C?CH, —C4H8—C?CH, —C2H4—C?C?—C2H5, —CH2—C?C—C3H7, —C?C—C4H9, —C?C—C(CH3)3, —CH(CH3)—C2H4—C?CH, —CH2—CH(CH3)—C?C—CH3, —CH(CH3)—CH2—C?C—CH3, —CH(CH3)—C?C—C2H5, —CH2—C?C—CH(CH3)2, —C?C—CH(CH3)—C2H5, —C?C—CH2—CH(CH3)2, —CH(C2H5)—C?C—CH3, —C(CH3)2—C?C—CH3, —CH(C2H5)—CH2—C?CH, —CH2—CH(C2H5)—C?CH, —C(CH3)2—CH2—C?CH, —CH2—C(CH3)2—C?CH, —CH(CH3)—CH(CH3)—C?CH, —CH(C3H7)—C?CH, —C(CH3)(C2H5)—C?CH, —CH2—CH(C?CH)2, —C?C—C?CH, —CH2—C?C—C?CH, —C?C—C?C—CH3, —CH(C?CH)2, —C2H4—C?C—C?CH, —CH2—C?C—CH2—C?CH, —C?C—C2H4—C?CH, —CH2—C?C—C?C—CH3, —C?C—CH2—C?C—CH3, —C?C—C?C—C2H5, —C(C?CH)2—CH3, —C?C—CH(CH3)—C?CH, —CH(CH3)—C?C—C?CH, —CH(C?CH)—CH2—C?CH, or —CH(C?CH)—C?C—CH3;
L1, represents: —CH2—, —C2H4—, —C3H6—, —C4H8—, —C5H10—, —C6H12—C7H14—, —C8H16—, —C9H18—, —C10H20—, —CH2CH2O—, —CH(CH3)—, —C[(CH3)2]—, —CH(C3H7)—, —CH2—CH(CH3)—, —CH(CH3)—CH2—, —CH(CH3)—C2H4—, —CH2—CH(CH3)—CH2—, —C2H4—CH(CH3)—, —CH2—C[(CH3)2]—, —C[(CH3)2]—CH2—, —CH(CH3)—CH(CH3)—, —C[(C2H5)(CH3)]—, —(CH2—CH2—O)n—CH2—CH2—, —C(CH3)?CH—C(CH3)?CH—, —C2H4—CH?CH—CH?CH—, —CH2—CH?CH—CH2—CH?CH—, —C3H6—C?C—CH2—, —CH2—CH?CH—CH?CH—CH2—, —CH(CH3)—C?C—CH2—, —CH?CH—CH?CH—C2H4—, —CH2—CH?CH—C(CH3)?CH—, —CH2—CH?C(CH3)—CH?CH—, —CH2—C(CH3)?CH—CH?CH—, —CH(CH3)—CH?CH—CH?CH—, —CH?CH—CH2—C(CH3)?CH—, —CONH—, —NHCO—, —CH2—CONH—, —CONH—CH2—, —NHCO—CH2—, or —CH2—NHCO—;
L2 and L3 represent independently of each other:
a bond, —CH2—, —C2H4—, —C3H6—, —C4H8—, —C5H10—, —C6H12—, —C7H14—, —C8H16—, —C9H18—, —C10H20—, —CH2CH2O—, —CH(CH3)—, —C[(CH3)2]—, —CH(C3H7)—, —CH2—CH(CH3)—, —CH(CH3)—CH2—, —CH(CH3)—C2H4—, —CH2—CH(CH3)—CH2—, —C2H4—CH(CH3)—, —CH2—C[(CH3)2]—, —C[(CH3)2]—CH2—, —CH(CH3)—CH(CH3)—, —C[(C2H5)(CH3)]—, —(CH2—CH2—O)n—CH2—CH2—, —C(CH3)?CH—C(CH3)?CH—, —C2H4—CH?CH—CH?CH—, —CH2—CH?CH—CH2—CH?CH—, —C3H6—C?C—CH2—, —CH2—CH?CH—CH?CH—CH2—, —CH(CH3)—C?C—CH2—, —CH?CH—CH?CH—C2H4—, —CH2—CH?CH—C(CH3)?CH—, —CH2—CH?C(CH3)—CH?CH—, —CH2—C(CH3)?CH—CH?CH—, —CH(CH3)—CH?CH—CH?CH—, —CH?CH—CH2—C(CH3)?CH—, —CONH—, —NHCO—, —CH2—CONH—, —CONH—CH2—, —NHCO—CH2—, or —CH2—NHCO—; and
wherein each n is an integer from 1 to 10; or
L1-RB and L2-RC or L1-RB and L3-RD or L2-RC and L3-RD form together a cyclic ring selected from the group consisting of:
or enantiomers, stereoisomeric forms, mixtures of enantiomers, anomers, deoxy-forms, diastereomers, mixtures of diastereomers, prodrugs, tautomers, hydrates, solvates or racemates thereof or pharmaceutically acceptable salts thereof.

US Pat. No. 10,246,409

METHOD FOR PREPARATION OF BIS(FLUOROSULFONYL)-IMIDE

Lonza Ltd, Visp (CH)

1. A method for the preparation of a compound of formula (I);
the method comprises a step STEP1;
STEP1 comprises a reaction REAC1-1;
in REAC1-1 a mixture MIXTURE-TRIPLE is reacted with HF at a temperature TEMP1-1, TEMP1-1 is at least 80° C.;
MIXTURE-TRIPLE comprises three components, a compound of formula (II), a compound of formula (III) and a compound of formula (IV);

X is identical with X1 or with X2;
X1 and X2 are identical or different and independently from each other selected from the group consisting of F, Cl, Br, I, RESF, and tolyl;
wherein RESF is a fluorinated C1-9 alkyl, which is unsubstituted or substituted by a substituent OCF3;
Rn+ is selected from the group consisting of H+, Li+, Na+, K+, Mg2+, Ca2+, Zn2+, Cu2+, Al3+, Ti3+, Fe2+, Fe3+, B3+,
[N(R20)(R21)(R22)R23]+, and [P(R20)(R21)(R22)R23]+;R20, R21, R22 and R23 are identical or different and independently from each other selected from the group consisting of H, C1-8 alkyl, C5-6 cycloalkyl, phenyl, benzyl, vinyl and allyl;
n is 1, 2 or 3;
wherein
the total content of the three components in MIXTURE-TRIPLE is of from 50 to 100%, the % being % by weight based on the total weight of MIXTURE-TRIPLE;
wherein
the relative ratio of the three components in MIXTURE-TRIPLE is of from
2 to 98% of the compound of formula (II),
49 to 1% of the compound of formula (III), and
49 to 1% of the compound of formula (IV);
the % are % by weight and are based on the combined weight of the three components in MIXTURE-TRIPLE; the relative ratios of the three components add up to 100%.

US Pat. No. 10,246,408

PROCESS FOR PREPARING BIPHENYLAMINES FROM ANILIDES BY RUTHENIUM CATALYSIS

BAYER CROPSCIENCE AKTIENG...

1. A process for preparing one or more biphenylamides of formula (Ia)
in which
R1 is hydrogen, hydroxyl, fluorine, chlorine, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylthio or C1-C4-haloalkyl,
R2 is C1-C4-alkyl, C6-C10-aryl or C6-C10-aryl-CH2—, and
X1 is hydrogen, C1-C3-alkyl, C1-C4-alkoxy, fluorine or chlorine,
X2 is hydrogen, C1-C3-alkyl, C1-C4-alkoxy, fluorine or chlorine,
X3 is hydrogen, C1-C3-alkyl, C1-C4-alkoxy, fluorine or chlorine,
comprising reacting one or more
anilides of formula (II)

in which
R1 and R2 are each as defined above,
with an organoboron compound of formula (III)

in which
X1, X2 and X3 are each as defined above,and which is selected from one of the following groups consisting of:(I) boronic acids of formula (III) in whichQ is a hydroxyl group,
m is 2,
p is 1,
or the anhydrides, dimers or trimers of these boronic acids;(II) boronic acid derivatives of formula (III) in whichQ is F, Cl, Br, I, C1-C4-alkyl, C6-C10-aryl, C1-C4-alkoxy or C6-C10-aryloxy,
m is 2,
p is 1;(III) borinic acids of formula (III) in whichQ is OH, F, Cl, Br, I, C1-C4-alkyl, C6-C10-aryl, C1-C4-alkoxy or C6-C10-aryloxy,
m is 1,
p is 2;(IV) cyclic boronic esters of formula (III) in whichQ is a C2-C3-alkyldioxy radical which, together with the boron atom to which it is bonded, forms a 5- or 6-membered ring optionally substituted by one or more C1-C4-alkyl radicals,
m is 1,
p is 1;(V) boronates of formula (III) in whichQ is OH, F, Cl, Br, I, C1-C4-alkyl, C6-C10-aryl, C1-C4-alkoxy or C6-C10-aryloxy,
m is 3,
p is 1
and the negative charge of the boronate anion is compensated for by a cation,(VI) triarylboranes of formula (III) in whichm is 0,
p is 3; and(VII) tetraarylborates of formula (III) in whichm is 0,
p is 4
and the negative charge of the tetraarylborate anion is compensated for by a cation,
in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal sulphate.

US Pat. No. 10,246,407

PROCESS FOR PREPARING BIPHENYLAMINES FROM ANILIDES BY RUTHENIUM CATALYSIS

BAYER CROPSCIENCE AKTIENG...

1. A process for the preparation of one or more biphenylamides of formula (V)
wherein
R1 is hydrogen, hydroxyl, fluorine, chlorine, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylthio or C1-C4-haloalkyl,
R2 is C1-C4-alkyl, C6-C10-aryl or C6-C10-aryl-CH2—, and
X1 is hydrogen, C1-C4-alkyl, C1-C4-alkoxy, fluorine or chlorine,
X2 is hydrogen, C1-C4-alkyl, C1-C4-alkoxy, fluorine or chlorine,
X3 is hydrogen, C1-C4-alkyl, C1-C4-alkoxy, fluorine or chlorine,comprising reacting one or more anilides of formula (II)
wherein
R1 and R2 are each as defined above,in a solvent selected from the group consisting of N,N-dialkylalkanamides, dimethoxyethane (DME), methanol, ethyl acetate, water, and mixtures of these solvents,with an organoboron compound of formula (III)
wherein
X1, X2 and X3 are each as defined above, and which is selected from one of the following groups consisting of:(i) boronic acids of formula (III) in whichQ is a hydroxyl group,
m is 2, and
p is 1,
or the anhydrides, dimers or trimers of these boronic acids;(ii) boronic acid derivatives of formula (III) in whichQ is F, C1, Br, I, C1-C4-alkyl, C6-C10-aryl, C1-C4-alkoxy or C6-C10-aryloxy,
m is 2, and
p is 1;(iii) borinic acids of formula (III) in whichQ is OH, F, C1, Br, I, C1-C4-alkyl, C6-C10-aryl, C1-C4-alkoxy or C6-C10-aryloxy,
m is 1, and
p is 2;(iv) cyclic boronic esters of formula (III) in whichQ is a C2-C3-alkyldioxy radical which, together with the boron atom to which it is bonded, forms a 5- or 6-membered ring optionally substituted by one or more C1-C4-alkyl radicals,
m is 1, and
p is 1;(v) boronates of formula (III) in whichQ is OH, F, C1, Br, I, C1-C4-alkyl, C6-C10-aryl, C1-C4-alkoxy or C6-C10-aryloxy,
m is 3, and
p is 1
and the negative charge of the boronate anion is compensated for by a cation,(vi) triarylboranes of formula (III) in whichm is 0, and
p is 3; and(vii) tetraarylborates of formula (III) in whichm is 0, and
p is 4
and the negative charge of the tetraarylborate anion is compensated for by a cation,
in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.

US Pat. No. 10,246,406

BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS AND USES THEREOF

QUADRIGA BIOSCIENCES, INC...

1. A compound of Formula (1):or a pharmaceutically acceptable salt thereof,wherein,R1 comprises a first chemotherapeutic moiety;
R4 is selected from the group consisting of hydrogen and a second chemotherapeutic moiety;
each of R2, R3, and R5 is hydrogen;
R6 is selected from the group consisting of —COOH, substituted C1-4 heteroalkyl, substituted C1-4 alkyl, and —PH(?O)(—OH), wherein each substituent group is independently selected from the group consisting of C1-3 alkyl, ?O, and C1-3 alkoxy;
each R7 is independently selected from the group consisting of hydrogen and hydroxyl;
R8 is selected from the group consisting of hydrogen and —CH3; and
L is selected from the group consisting of a bond, —CH2—, —CH2—O—, —CH2—CH2—, —CH(—OH)—, —C(?O)—NH—, —C(?O)—N(—CH3)—, and —CH2—C(?O)—,
wherein each of the first chemotherapeutic moiety and the second chemotherapeutic moiety is independently selected from the group consisting of —N(—CH2—CH2—Cl)2, —N(—CD2-CD2-Cl)2, —N(—CH2—CH2—Br)2, —N(—CH2—CH2—OH)2, —CH2—N(—CH2—CH2—Cl)2, —CH2—C(?O)—N(—CH2—CH2—Cl)2, —O—C(?O)—N(—CH2—CH2—Cl)2, —NH—C(?O)—CH2—Br, —CH2—O—C(?O)—N(—CH2—CH2—Cl)2, —N(—CH2—CH2—Cl)(—CH2—CH2—OH), —N(—O—CH2—CH2—Cl)(—CH2—CH2—Cl), —NH—CH2—CH2—Cl, —NH—CH2—CH2—OH, —N+(—O?)(—CH2—CH2—Cl)2, —N(—CH2—CH2—O—S(?O)2—CH3)2, —N(—CH2—CH2—Cl)(—CH2—CH2—O—S(?O)2—CH3), —N(—CH2—CH2—Br)(—CH2—CH2—O—S(?O)2—CH3), —N(—CH2—CH2—Cl)(—CH2—CH2—Br), and

US Pat. No. 10,246,404

BIFUNCTIONAL COMPOUND HAVING NORBORNANE SKELETON AND PRODUCTION METHOD THEREFOR

Mitsubishi Gas Chemical C...

1. A bifunctional compound, represented by formula (1):
wherein
R1 is a hydrogen atom, CH3, or C7H5;
R2 and R3 are each independently a hydrogen atom or CH3; and
X is a hydrogen atom or a hydrocarbon group comprising no more than 4 carbon atoms and optionally a hydroxyl group.

US Pat. No. 10,246,401

CRYSTALLINE FORM OF CHLOROGENIC ACID AND PREPARATION METHOD THEREOF

SICHUAN JIUZHANG BIOLOGIC...

3. A process for preparing a crystalline form of chlorogenic acid of claim 1, comprising:dissolving a crude chlorogenic acid with a purity of more than 90% and less than or equal to 98% in water to obtain a first solution;
filtering the first solution with a filter to obtain a first filtrate;
freezing the first filtrate to 5° C. to obtain a second solution;
filtering the second solution to get a filter residue; and
freeze-drying the filter residue to obtain the claimed crystal form of chlorogenic acid.

US Pat. No. 10,246,398

ADDITIVES FOR CARBOXYLIC ACID PRODUCTION PROCESSES

LyondellBasell Acetyls, L...

1. A process comprising:contacting methanol and carbon monoxide in the presence of a liquid reaction medium under carbonylation conditions sufficient to form a carbonylation product comprising acetic acid, wherein the liquid reaction medium comprises:
a carbonylation catalyst selected from rhodium catalysts, iridium catalysts and palladium catalysts;
1-6 wt. % water, based on the total liquid reaction medium weight; and
0.05-2.0 M of an additive selected from di-sodium glutamate salts, tri-sodium glutamate salts, di-sodium L-3-(4-hydroxyphenyl) alanine, tri-sodium N,N-bis(carboxymethyl)-DL-alanine, and combinations thereof; and
recovering acetic acid from the carbonylation product.

US Pat. No. 10,246,390

PROCESS FOR THE SEPARATION OF GLYCOLS USING GLYCEROL

SHELL OIL COMPANY, Houst...

1. A process for the separation of monoethylene glycol (MEG) and 1,2-butanediol (1,2-BDO) from a first mixture comprising MEG and 1,2-BDO, said process comprising the steps of:(i) providing said first mixture comprising MEG and 1,2-BDO as a feed to a distillation column;
(ii) providing a feed comprising glycerol to the distillation column above the first mixture;
(iii) operating the distillation column at a temperature in the range of from 50 to 250° C. and a pressure in the range of from 0.1 to 400 kPa;
(iv) removing a stream comprising MEG and glycerol as a bottoms stream from the distillation column; and
(v) removing a stream comprising 1,2-BDO above the point at which the feed comprising glycerol is provided to the distillation column.

US Pat. No. 10,246,386

EMBEDDED ALKANE DEHYDROGENATION SYSTEMS AND PROCESSES

SABIC GLOBAL TECHNOLOGIES...

1. A system for dehydrogenating an alkane, comprising:a furnace;
one or more alkane heating chambers located within the furnace for preheating an alkane feed;
one or more regeneration mixture heating chambers located within the furnace for preheating a regeneration mixture feed;
a first group of two or more reaction chambers located within the furnace for dehydrogenating an alkane, the first group of reaction chambers being switchably coupled to the one or more alkane heating chambers to receive a heated alkane feed therefrom, and switchably coupled to the one or more regeneration mixture heating chambers to receive a heated regeneration mixture feed therefrom; and
a second group of two or more reaction chambers located within the furnace for dehydrogenating an alkane, the second group of reaction chambers being switchably coupled to the one or more alkane heating chambers to receive a heated alkane feed therefrom, and switchably coupled to the one or more regeneration mixture heating chambers and configured to receive a heated regeneration mixture feed therefrom;
the system being configured such that when the first group of reaction chambers are switched to receive the heated alkane feed, the second group of reaction chambers are switched to receive the heated regeneration mixture feed; and
when the first group of reaction chambers is switched to receive the heated regeneration mixture feed, the second group of reaction chambers is switched to receive the heated alkane feed;
wherein the system further comprises a first heated alkane feed line coupled to a heated alkane outlet line and further coupled to the first group of reaction chambers, for feeding the heated alkane from the heated alkane outlet line to the first group of reaction chambers, the first heated alkane feed line comprising a first heated alkane feed line valve;
a second heated alkane feed line coupled to the heated alkane outlet line and further coupled to the second group of reaction chambers, for feeding the heated alkane from the heated alkane outlet line to the second group of reaction chambers, the second heated alkane feed line comprising a second heated alkane feed line valve;
a first heated regeneration mixture feed line coupled to a heated regeneration mixture outlet line and further coupled to the first group of reaction chambers, for feeding the heated regeneration mixture from the heated regeneration mixture outlet line to the first group of reaction chambers, the first heated regeneration mixture feed line comprising a first heated regeneration mixture feed line valve; and
a second heated regeneration mixture feed line coupled to the heated regeneration mixture outlet line and further coupled to the second group of reaction chambers, for feeding the heated regeneration mixture from the heated regeneration mixture outlet line to the second group of reaction chambers, the second heated regeneration mixture feed line comprising a second heated regeneration mixture feed line valve;
wherein the first heated alkane feed line and the second heated alkane feed line each extend out of the furnace and each are separately directed back into the furnace after passing through the first heated alkane feed line valve and the second heated alkane feed line valve, respectively;
wherein the first heated regeneration mixture feed line and the second heated regeneration mixture feed line each extend out of the furnace and each separately are directed back into the furnace after passing through the first heated regeneration mixture feed line valve and the second heated regeneration mixture feed line valve, respectively;
where the first heated alkane feed line and the second heated alkane feed line are separate from one another and from the first heated regeneration mixture feed line and the second heated regeneration mixture feed line and wherein the first heated regeneration mixture feed line and the second heated regeneration mixture feed line are separate from one another and from the first heated alkane feed line and the second heated alkane feed line.

US Pat. No. 10,246,385

INTEGRATED PYROLYSIS AND OXYGENATE TO OLEFIN PROCESS

UOP LLC, Des Plaines, IL...

1. A method of making light olefins comprising:combusting a fuel and an oxidizer in a combustion zone of a pyrolytic reactor to create a combustion gas stream;
transitioning a velocity of the combustion gas stream from subsonic to supersonic in an expansion zone of the pyrolytic reactor;
injecting a light hydrocarbon into the supersonic combustion gas stream to create a mixed stream including the light hydrocarbon;
transitioning the velocity of the mixed stream from supersonic to subsonic in a reaction zone of the pyrolytic reactor to produce a reaction mixture comprising an alkyne, carbon oxide, and hydrogen;
separating the reaction mixture in an absorber into an alkyne stream comprising the alkyne and a byproduct stream comprising the carbon oxide and the hydrogen;
catalytically hydrogenating the alkyne in a hydrogenation zone to produce a product stream containing a first light olefin;
treating the byproduct stream to convert at least a portion of the carbon oxide and the hydrogen to an oxygenated product in a carbon oxide conversion zone;
treating the oxygenated product in an oxygenate conversion zone to convert at least a portion of the oxygenated product to produce an effluent comprising a second light olefin; and
separating the first light olefin from the product stream and separating the second light olefin from the effluent in a product separation zone.

US Pat. No. 10,246,382

CATALYTIC SYSTEMS AND METHODS FOR PROCESS STREAM TREATMENT

SIEMENS ENERGY, INC., Or...

1. A method of producing methane comprising:subjecting an aqueous fluid comprising an organic compound capable of being hydrolyzed to catalytic conditions effective to hydrolyze the at least one organic compound in the aqueous fluid while generating an amount of methane therefrom;
wherein the catalytic conditions comprise contacting the aqueous fluid with a heterogeneous catalyst comprising ruthenium, and the organic compound capable of being hydrolyzed comprises a kinetic hydrate inhibitor and/or a hydrolyzed polyacrylamide.

US Pat. No. 10,246,381

STABILIZED NITROCELLULOSE-BASED PROPELLANT COMPOSITION

PB CLERMONT SA, Engis (B...

1. A nitrocellulose-based propellant composition comprising(a) a nitrate ester based propellant, and
(b) a stabilizer consisting of a general formula (I):
wherein:R1 represents, alkyl substituted or not;R2 represents:(i) H;
(ii) unsaturated alkyl group;
R3 represents, H, alkyl substituted or not, or OR8;R4 represents, alkyl substituted or not, aromatic ring substituted or not, or OR8;R5 represents, alkyl substituted or not, aromatic ring substituted or not, or OR9;R6 represents, aromatic ring substituted or not;R7 represents, alkyl substituted or not;R8 represents, alkyl substituted or not, or aromatic ring substituted;R9 represents, alkyl substituted or not, or aromatic ring substituted.

US Pat. No. 10,246,376

LEAD-FREE PIEZOCERAMIC MATERIAL BASED ON BISMUTH SODIUM TITANATE (BST)

PI CERAMIC GMBH, Lederho...

1. A lead-free piezoceramic material based on bismuth sodium titanate (BST) of the fundamental compositionx(Bi0.5Na0.5)TiO3-yBaTiO3-zSrTiO3 with x+y+z=1 and 0 x(Bi0.5Na0.5)TiO3-yBaTiO3-zCaTiO3 with x+y+z=1 and 0 characterized by the addition of a phosphoric material in a quantity such that the concentration of phosphorus in the piezoceramic material is 250 to 2000 ppm, wherein the specification ppm (parts per million) relates to the mass of phosphorus in relation to the total mass of the piezoceramic composition.

US Pat. No. 10,246,375

MULTI-PHASE HIGH THERMAL CONDUCTIVITY COMPOSITE DIELECTRIC MATERIALS

SKYWORKS SOLUTIONS, INC.,...

7. A multi-phase composite ceramic material comprising at a generally contiguous primary phase of aluminum oxide and a plurality of secondary phases, a first of the plurality of secondary phases being CaTiO3 and a second of the plurality of secondary phases being selected from the group consisting of LaAlO3, La2MgTiO6, YAlO3, SmAlO3, Mg4Nb2O9, and La4Ti3O12, the plurality of secondary phases embedded within the primary phase to form a multi-phase composite ceramic material having a dielectric constant of greater than 20.

US Pat. No. 10,246,374

METHOD FOR MANUFACTURING GLASS FILM LAMINATE, GLASS FILM LAMINATE, AND METHOD FOR MANUFACTURING ELECTRONIC DEVICE

NIPPON ELECTRIC GLASS CO....

1. A glass film laminate produced by laminating directly a glass film and a support glass,characterized in that
all edge sides of the glass film contact the support glass without clearance,
wherein the glass film contacts the support glass without clearance with a width not less than 10 mm from all the edge sides of the glass film,
wherein a number of bubbles in a part of the glass film laminate except for the part in which the glass film contacts the support glass without clearance is not less than 0.1/m2 and not more than 10000/m2.

US Pat. No. 10,246,366

METHOD OF MANUFACTURING OPTICAL FIBER BASE MATERIAL AND METHOD OF MANUFACTURING OPTICAL FIBER

FUJIKURA LTD., Tokyo (JP...

1. A method of manufacturing an optical fiber base material comprising steps of:(a) preparing a glass tube; and
(b) rotating and heating the glass tube fixed at two positions and supplying a gas into a through-hole of the glass tube,
wherein the glass tube is fixed such that an axis of the glass tube has a substantially inverted catenary curve shape in the vertical direction while the glass tube is heated.

US Pat. No. 10,246,365

APPARATUS AND METHOD FOR FORMING THIN GLASS ARTICLES

CORNING INCORPORATED, Co...

1. A method of forming a glass article comprisingsupplying a glass ribbon in a first direction, at least a portion of the glass ribbon exhibiting a viscosity of less than about 108 poise and greater than about 106 poise; and
redirecting the glass ribbon to a second direction different from the first direction without contacting the glass ribbon with a solid material,
wherein the glass ribbon exhibits a thickness of about 1 mm or less in the second direction, and the at least a portion of the glass ribbon exhibits a viscosity of less than 107.4 poise and greater than 106 poise during the redirecting.

US Pat. No. 10,246,363

TEXTURED GLASS FOR GREENHOUSES

SAINT-GOBAIN GLASS FRANCE...

1. A transparent sheet comprising a texture in relief on a first main face of its main faces to form a textured face, such that, if n is the refractive index of a material comprising the texture, Pm is the mean slope in degrees of the textured face and Y(q) is the percentage of the textured surface with a slope greater than q/(n?1) in degrees, then the two cumulative conditions exist:Y(q)>3%+f(q)%*Pm*(n?1)
and Y(q)>10%
with f(q)=24?(3*q)
and q=2 or 3.

US Pat. No. 10,246,362

EFFECTIVE DISCHARGE OF EXHAUST FROM SUBMERGED COMBUSTION MELTERS AND METHODS

Johns Manville, Denver, ...

1. A submerged combustion manufacturing system comprising:a submerged combustion melter (SCM) equipped with one or more submerged combustion (SC) burners, the SCM having a length (L) and a width (W), a centerline (C), a midpoint (M), a sidewall structure having a north side (N) and a south side (S), the sidewall structure connecting a ceiling and a floor of the SCM, and one or more exhaust passages through the ceiling, the one or more exhaust passages having an aggregate hydraulic diameter;
the one or more submerged combustion burners configured to discharge combustion products under a level of material being melted in the SCM and create turbulent conditions in substantially all of the material being melted as well as ejected portions of melted material; and
an exhaust structure fluidly connecting the one or more exhaust passages with an exhaust stack, the exhaust structure comprising:
a liquid-cooled exhaust structure of height H1 fluidly connected to the one or more exhaust passages, the liquid-cooled exhaust structure defining a liquid-cooled exhaust chamber having a first interior surface, the liquid-cooled exhaust chamber having a cross-sectional area greater than that of the exhaust stack but less than the SCM,
the one or more exhaust passages and the liquid-cooled exhaust structure configured to maintain temperature and pressure of exhaust materials from the SCM, and exhaust velocity of the exhaust materials from the SCM through the liquid-cooled exhaust structure, at values sufficient to prevent the ejected portions of melted material from being propelled out of the liquid-cooled exhaust structure and into the exhaust stack as solidified material, and maintain any molten materials contacting the first interior surface molten so that it flows back down the first interior surface back into the SCM, and
a gas-cooled exhaust structure of height H7 fluidly connecting the liquid-cooled exhaust structure and the exhaust stack, the gas-cooled exhaust structure defining a gas-cooled exhaust chamber having a second interior surface, the gas-cooled exhaust structure consisting of a metal layer forming the second interior surface, the metal layer having one or more gas-cooled external surfaces, the gas-cooled exhaust structure devoid of refractory or other lining,
wherein H1 is greater than or equal to H7, and H7 is not 0.

US Pat. No. 10,246,361

METHOD FOR MANUFACTURING MOLTEN GLASS, METHOD FOR MANUFACTURING GLASS PRODUCT, AND DEVICE FOR MANUFACTURING MOLTEN GLASS

AGC Inc., Chiyoda-ku (JP...

1. A process for producing molten glass comprising:melting a raw glass material in a melting furnace to prepare glass melt;
supplying a water-molecules supply gas into the glass melt flowing from an upstream end of the melting furnace toward a downstream end of the melting furnace; and
degassing, under a reduced pressure atmosphere, the glass melt flowing out of the downstream end;
wherein a position where the water-molecules supply gas is supplied in the water-molecules supply step includes a first position and a second position from downstream to upstream in a flowing direction of the glass melt in this order;
the first position is a position away from both of the upstream end and the downstream end; and
the second position is a position closer to the upstream end than a center of a distance between the upstream end and the first position in the flowing direction of the glass melt;
wherein the water-molecules supply gas supplied at the second position has a smaller floating force than the water-molecules supply gas supplied at the first position.

US Pat. No. 10,246,360

METHOD FOR THE CONTINUOUS THERMAL HYDROLYSIS OF SLUDGE WITH A HIGH DRYNESS VALUE

1. A method for the continuous thermal hydrolysis of sludge to be treated containing organic matter, the method comprising at least:a. a step for de-structuring said sludge to be treated producing de-structured sludge, said sludge having a dry solids content greater than 20% (wt.);
b. a step for the thermal hydrolysis of said de-structured sludge within a thermal hydrolysis reactor producing hydrolyzed sludge;
c. a step for cooling said hydrolyzed sludge;
said step for de-structuring including:
introducing said sludge to be treated into a dynamic mixer comprising a chamber and a rotor
injecting steam into the dynamic mixer;
rotating the rotor at a speed gradient between 1500 rpm and 4000 rpm to mix and de-structure the sludge;
heating said sludge coming from said dynamic mixer, this heating being obtained by the introduction, into a heat exchanger, on the one hand of said sludge coming from said dynamic mixer and, on the other hand, of said hydrolyzed sludge, this introduction inducing said cooling.

US Pat. No. 10,246,359

SYSTEM AND METHOD FOR TREATING WASTEWATER

New Environmental Enginee...

1. An activated sludge treatment system for treating wastewater, comprising:a) one or more primary treatment tanks adapted to settle solids out of polluted influent;
b) at least one flow equalization channel;
c) one or more secondary treatment tanks adapted to digest organic materials in primary-treated wastewater with aerobic micro-organisms, comprising:
(i) a liquid distribution manifold connected to one or more venturis suspended within the one or more secondary treatment tanks, wherein said one or more venturis are adapted to discharge an air/liquid mixture into said one or more secondary treatment tanks, and
(ii) an air distribution manifold connected to the one or more venturis suspended within the one or more secondary treatment tanks;
d) at least one collection channel connected to the one or more secondary treatment tanks and adapted to deliver secondary-treated wastewater to one or more sedimentation tanks;
e) wherein the one or more sedimentation tanks are connected directly or indirectly to one or more return activated sludge pipelines;
f) said one or more return activated sludge pipelines being adapted to carry return activated sludge to the one or more secondary treatment tanks;
g) one or more return activated sludge pumps adapted to pump return activated sludge through the one or more return activated sludge pipelines;
h) one or more secondary supernatant discharge lines connected to the one or more sedimentation tanks;
i) one or more secondary supernatant pumps adapted to pump secondary supernatant from the one or more sedimentation tanks through the one or more secondary supernatant discharge lines to the liquid distribution manifold; and
j) one or more air compressors adapted to pump air to the air distribution manifold.

US Pat. No. 10,246,358

AUTOMATED PRIMARY CONDENSATE DRAIN LINE CHLORINATION SYSTEM AND METHOD

1. An automated primary condensate drain line chlorination system for introducing chlorine and algaecides into a primary condensate drain line of a central air conditioning system upon and a selected period of time after operation of the air conditioning system to prevent microbial growth in a primary condensate drain tray, the condensate drain line, and along a condensate drain system flow path, comprising:a first T-fitting installed in an existing municipal water supply line that contains chlorine and algaecides, the first T-fitting having a perpendicular leg configured to divert a portion of the municipal water from the water supply line;
a second T-fitting installed between an outlet of an existing primary condensation tray of the central air conditioning system and the existing primary condensate drain line and having a perpendicular leg;
a water supply line extending between the perpendicular leg of the first T-fitting and the perpendicular leg of the second T-fitting; and
a normally closed solenoid valve with a programmable timer installed in the water supply line between the perpendicular leg of the first T-fitting and the perpendicular leg of the second T-fitting, a solenoid of the solenoid valve operatively connected with, and powered by, an existing electrical circuit of a thermostat and fan motor of the central air conditioning system, and the solenoid valve having a flow path bore configured to allow a small amount of the municipal water containing chlorine and algaecides to pass through the valve in its open position; wherein
the solenoid valve is opened automatically upon operation of a fan of an evaporator unit of the central air conditioning system and the programmable timer is programmed to maintain the valve open for the selected period of time after the fan ceases to operate to allow the small amount of the municipal water containing chlorine and algaecides from the existing municipal water supply line to continue flowing through the solenoid valve, through the second T-fitting, and into both the primary condensation tray and the primary condensate drain line for the selected period of time; and
the chlorine and algaecide constituents in the municipal water effectively prevent the growth of algae and/or fungus in both the primary condensate drain tray and the condensate drain line, and along the condensate drain system flow path.

US Pat. No. 10,246,355

AQUACULTURE SYSTEM

YUAN ZE UNIVERSITY, Taoy...

1. An aquaculture system, comprising:a culture pond for storing a cultivation water of a predetermined water level, wherein the culture pond has a recirculation inlet and a recirculation outlet;
a water circulation unit arranged between the recirculation inlet and the recirculation outlet, the water circulation unit is in fluid communication with the recirculation inlet and the recirculation outlet, and the cultivation water is circulated by the water circulation unit;
a water quality detector disposed in at least one of the culture pond and the water circulation unit for detecting the water quality of the cultivation water and obtaining a piece of water quality information; and
a water processing module comprising:
an electrolytic gas generator in fluid communication with the water circulation unit and for generating a first gas and a second gas by electrolyzing water, wherein the electrolytic gas generator has a first outlet tube and a second outlet tube independently in fluid communication with the water circulation unit for unidirectionally outputting the first gas and the second gas into the water circulation unit, respectively; and
a control unit electrically connected to the electrolytic gas generator and the water quality detector, wherein the control unit receives the water quality information and controls the electrolytic gas generator to adjust a voltage value for electrolyzing water based on the water quality information to control a type of the first gas and a ratio of the first gas to the second gas generated by the electrolytic gas generator,
wherein the cultivation water is circulated in the water circulation unit without flowing into the electrolytic gas generator.

US Pat. No. 10,246,354

DEVICE FOR PREPARING WASHING WATER

DALIAN SHUANGDI INNOVATIV...

1. A device for preparing washing water, comprising a water container which is respectively provided with a water inlet and a water outlet; at least one pair of a cathode and an anode being coupled with each other and arranged within the water container; wherein, a water-permeable porous membrane is clamped between the coupled cathode and anode with no gaps between the water-permeable porous membrane and the cathode and between the water-permeable porous membrane and the anode, a surface area of a side of the water-permeable porous membrane facing the cathode or the anode is smaller than a surface area of a side of the cathode or of the anode facing the water-permeable porous membrane, and a ratio of the surface area of a side of the water-permeable porous membrane to the smaller one of the surface area of a side of the cathode and the surface area of a side of the anode is 4:5-3:5.

US Pat. No. 10,246,353

APPARATUS FOR ELECTROCOAGULATION TREATMENT OF A LIQUID

KOLINA LIMITED, Hertford...

1. A flow-through assembly for electrocoagulation treatment of a liquid, the assembly comprising:a) a cartridge comprising sacrificial electrodes,
b) a chamber comprising:
an enclosure arranged for removable retention of the cartridge comprising sacrificial electrodes,
an opening through which the cartridge is removable from the enclosure,
an inlet port and an outlet port in the chamber arranged for flow of said liquid, into the inlet port, over the sacrificial electrodes in the enclosure, and out of the outlet port,
c) a chamber door pivotably movable relative to the chamber through a hinge arrangement about which the door is pivotable between an open configuration and a closed configuration of the chamber door, wherein
in the closed configuration, an inner face of the chamber door is adapted to form a liquid tight seal at the opening, and
in the open configuration, the cartridge is removable from the enclosure through the opening,
wherein the chamber door comprises a first electrode on its inner face and the chamber comprises a second electrode positioned relative to the first electrode such that the sacrificial electrodes of the cartridge are located between the first and second electrodes with the chamber door in the closed configuration;
wherein the assembly further comprises a casing body and a casing door, the casing body and the casing door configured to retain and surround the chamber and the chamber door therein;
wherein the casing door is hinged to the casing body to be pivotable between an open position and a closed position of the casing door, and wherein in the closed position, the casing door is arranged to hold the chamber door in the closed configuration of the chamber door; and
wherein the casing body comprises a mechanical fastener arrangeable to releasably hold the casing door in the closed position.

US Pat. No. 10,246,350

HIGH VELOCITY CROSS FLOW DYNAMIC MEMBRANE FILTER

PRO-EQUIPMENT, INC., Wau...

1. A method of operating a high velocity cross flow dynamic membrane filtration system, the method comprising:feeding a fluid stream into a pressure vessel, the vessel defining a treatment chamber containing a disc membrane assembly having a first support shaft and a second support shaft, each support shaft defining a longitudinal axis about which is positioned a plurality of axially spaced membrane discs;
distributing the fluid stream over at least a portion of the disc membrane assembly;
discharging a first portion of the fluid stream from the vessel;
discharging a second portion of the fluid stream from the vessel; and
rotating the first support shaft and the second support shaft in a first direction,
wherein the vessel defines a length between a first end and a second end and includes a plurality of discharge ports spaced along the length, and wherein discharging the first portion of the fluid stream from the vessel includes discharging the first portion through any combination of one or more discharge ports of the plurality of discharge ports.

US Pat. No. 10,246,348

ULTRAVIOLET DISINFECTION SYSTEM

RayVio Corporation, Hayw...

1. A water disinfection vessel comprising:an inner wall of the vessel that reflects light;
a first ultraviolet (UV) light emitting diode (LED) injecting UV light into the vessel;
a first optical detector detecting a transparency of water in the vessel, wherein the transparency is related to impurities in the water;
a second LED that emits non-UV light of a wavelength that is absorbed by microbes in the water, wherein the first optical detector detects light from the second LED that passes through the water to detect absorption of light by the microbes;
a controller circuit configured to receive signals from the first optical detector to determine the transparency of the water; and
the controller circuit configured to control a UV dosage from the first UV LED based, at least in part, on the transparency of the water.

US Pat. No. 10,246,347

BIOCHAR TREATMENT OF CONTAMINATED WATER

SOUTHWEST RESEARCH INSTIT...

1. A method for treatment of water to produce recycled water comprising:providing water for treatment containing organic and inorganic contaminants;
filtering the water containing organic and inorganic contaminants through a particulate filter to remove 60 mesh or larger particulate contaminants present in the water thereby providing filtered water containing organic and inorganic contaminants;
supplying a plurality of biochar sorbent bed pairs, each biochar sorbent bed pair including a first biochar sorbent bed and a second biochar sorbent bed arranged in parallel such that flow alternates between the first biochar sorbent bed and the second biochar sorbent bed,wherein biochar contained in said biochar sorbent beds is made by heating biomass in a low or no oxygen environment for 1.0-3.0 hours a temperature of 300° C. to 600° C. to provide biochar sorbent having a surface area in the range of 200 m2-500 m2;supplying said filtered water containing organic and inorganic contaminants to at least one biochar sorbent bed in at least one of said plurality of biochar sorbent bed pairs wherein said biochar removes all or a portion of said contaminants to produce recycled water;
recovering said recycled water wherein said levels of contaminants are reduced or removed;
regenerating said at least one biochar sorbent bed in at least one of said plurality of biochar sorbent bed pairs using steam to remove at least a portion of said contaminants from said at least one biochar sorbent bed followed by washing the biochar absorbent bed with a solution of sodium carbonate to precipitate and remove metal ions from the biochar absorbent bed; and
recycling at least a portion of a condensate from said steam used to regenerate said at least one biochar sorbent bed to said particulate filter.

US Pat. No. 10,246,346

COMPOSITIONS AND METHODS FOR THE REMOVAL OF PHOSPHATES AND OTHER CONTAMINANTS FROM AQUEOUS SOLUTIONS

NClear Inc., Atlanta, GA...

1. A method of producing a composition capable of removing phosphates, nitrates and heavy metals from a solution, comprising:(a) forming a slurry comprising calcium oxide, silicon dioxide, an alkali and a solvent, wherein the molar ratio of the calcium oxide:the silicon dioxide:the alkali ranges from 2.43-2.97:1.12-1.38:0.9-1.1; and
(b) producing the composition capable of removing phosphates, nitrates and heavy metals from a solution by subjecting the slurry to a hydrothermal process for about 1 to about 6 hours under about 13.5 to 16.5 psi of pressure.

US Pat. No. 10,246,342

CENTRIFUGAL ALUMINUM CHLORIDE GENERATOR

Tronox LLC, Oklahoma Cit...

1. A chloride process for manufacturing titanium dioxide, comprising:introducing titanium dioxide ore, a carbon source and chlorine into a chlorinator;
operating said chlorinator under conditions sufficient to cause titanium dioxide ore, said carbon source and chlorine in said chlorinator to react to form titanium tetrachloride;
introducing metal particles and chlorine into a metal chloride generator, wherein said metal chloride generator is a metal chloride centrifugal reactor;
operating said metal chloride generator under conditions sufficient to cause metal particles and chlorine in said generator to be brought into contact with one another and react using centrifugal force to form metal chloride;
introducing titanium tetrachloride formed in said chlorinator, metal chloride formed in said metal chloride generator and oxygen into an oxidizer;
operating said oxidizer under conditions sufficient to oxidize titanium tetrachloride and metal chloride in said oxidizer to form titanium dioxide particles having a metal oxide incorporated into their crystalline lattice structure; and
recovering titanium dioxide particles formed in said oxidizer.

US Pat. No. 10,246,341

METHOD FOR PRODUCING LITHIUM CARBONATE FROM LOW-LITHIUM BRINE BY SEPARATING MAGNESIUM AND ENRICHING LITHIUM

XIANGTAN UNIVERSITY, Xia...

1. A method for producing lithium carbonate from low-lithium brine by separating magnesium and enriching lithium, comprising:a. heating, evaporating and condensing a salt-lake brine to separate halide salts;
b. extracting the separated halide salts with trialkyl phosphate or a mixture of trialkyl phosphate and monohydric alcohol as an organic phase;
wherein a ratio of weight (kg) of the separated halide salts to a volume (L) of the organic phase is 1.0:0.5˜5.0;
c. filtering a mixture from step b to produce an organic phase and remaining halide salts after a two-phase separation;
d. reverse extracting the organic phase from step c with water as a reverse extraction agent at a volume ratio of water to organic phase of 1.0:0.5˜10.0 in 1-5 stages of reverse extraction;
e. separating the organic phase from the water of step d after liquid layers are formed and then evaporating and concentrating the separated water to obtain a concentrated water phase;
f. adding sodium carbonate or sodium hydroxide into the concentrated water phase from step e to precipitate magnesium carbonate or magnesium hydroxide, and then filtering the precipitated magnesium carbonate or magnesium hydroxide to remove Mg2+, wherein the water phase has a pH of more than 10 to completely precipitate Mg2+; and
g. adding sodium carbonate into the water phase with Mg2+ removed from step f to precipitate lithium carbonate, and then filtering and drying the precipitated lithium carbonate to produce a final product.

US Pat. No. 10,246,340

AMMONIA SYNTHESIS SYSTEM AND METHOD

MITSUBISHI HEAVY INDUSTRI...

1. An ammonia synthesis method comprising:an ammonia synthesis step of synthesizing an ammonia gas from a raw material gas for ammonia synthesis;
a water-cooled or air-cooled cooling step of water-cooling or air-cooling a synthetic gas containing the obtained ammonia gas and an unreacted raw material gas without using a product ammonia as a chiller refrigerant;
an ammonia separation step of separating the synthetic gas after cooling into the ammonia gas and a liquid ammonia; and
a compression step of compressing a return raw material gas when the raw material gas containing the separated ammonia gas is returned to the ammonia synthesis step side as the return raw material gas, wherein
an ammonia concentration in the return raw material gas to be introduced into the ammonia synthesis step is 5 mol % or more, and an ammonia synthesis catalyst that synthesizes the ammonia gas is a ruthenium catalyst, and
the temperature of the synthetic gas after cooling, to be introduced in the ammonia separation step is from 30 to 50° C.

US Pat. No. 10,246,335

METHODS OF MODIFYING SURFACES OF DIAMOND PARTICLES, AND RELATED DIAMOND PARTICLES AND EARTH-BORING TOOLS

Baker Hughes, a GE compan...

1. A method of modifying surfaces of diamond particles, comprising:forming spinodal alloy coatings over discrete diamond particles while the discrete diamond particles are mobilized by a particle dispersing apparatus;
thermally treating the spinodal alloy coatings to form modified coatings each independently exhibiting a reactive metal phase and a substantially non-reactive metal phase; and
etching surfaces of the discrete diamond particles with at least one reactive metal of the reactive metal phase of the modified coatings.

US Pat. No. 10,246,331

METHOD, APPARATUS AND SPECIAL PHOSPHORUS RECOVERY DEVICE FOR RECOVERING YELLOW PHOSPHORUS FROM ELECTRIC FURNACE PHOSPHORUS-PRODUCING FURNACE GAS

Intermet Technologies Che...

1. A method for recovering yellow phosphorus from furnace gas resulting from preparing phosphorus in an electric furnace, comprising:1) dedusting and purifying the furnace gas using a dry dedusting system when the temperature of the electric furnace is at least the dew point temperature of the phosphorous vapor in the furnace gas, which results in a solid content of the furnace gas to be 10-50 mg/m3;
2) the purified furnace gas is delivered to a phosphorus collecting apparatus (7) having a heat exchanging chamber (705) consisting of a shell (701) and a recuperator (702) set in the heat exchanging chamber (705), and said furnace gas flows into the heat exchanging chamber (705) so as to fully contact with the recuperator (702);
3) a low temperature medium is introduced into the internal flow path of the recuperator (702), the low temperature medium and said furnace gas are heat transferred by a non-mixing means under the isolation of the recuperator (702), so that the yellow phosphorus is condensed, precipitated and adhered to the surface of the recuperator (702), and the exhaust gas after heat exchanging is discharged from the phosphorus collecting apparatus (7); and
4) a high temperature medium for replacing the low temperature medium is introduced into the internal flow path of the recuperator (702), the high temperature medium and the yellow phosphorus adhered to the surface of the recuperator (702) are heat transferred by the non-mixing means, so that the yellow phosphorus melts and drops into a phosphorus collecting tank (703) at the bottom of the phosphorus collecting apparatus (7), and then the yellow phosphorus is obtained through the phosphorus collecting tank (703).

US Pat. No. 10,246,330

SYSTEMS AND PROCESSES FOR REMOVING HYDROGEN SULFIDE FROM GAS STREAMS

Marsulex Environmental Te...

10. A process of capturing hydrogen sulfide from a gas stream and oxidizing captured hydrogen sulfide to form a thiosulfate, a sulfate, or a combination thereof, the process comprising:obtaining a gas stream containing hydrogen sulfide, the gas stream being natural gas, refinery process gas, or syngas from gasification;
contacting the gas stream with an ammoniated aqueous absorbent solution containing ammonia and ammonium thiosulfate and/or ammonium sulfate, the ammonia reacting with the hydrogen sulfide to form sulfides in the ammoniated aqueous absorbent solution;
controlling pH of the ammoniated aqueous absorbent solution during the contacting step by adding ammonia to the ammoniated aqueous absorbent solution;
oxidizing the ammoniated aqueous absorbent solution to convert at least some of the sulfides thereof to form an additional amount of ammonium thiosulfate and/or ammonium sulfate, thereby producing a second absorbent solution that contains the additional amount of ammonium thiosulfate and/or ammonium sulfate and has a lower sulfide content than the ammoniated aqueous absorbent solution; and
delivering a first portion of the second absorbent solution for use in the contacting step to capture residual hydrogen sulfide in the gas stream and capture ammonia emitted from the first absorbent solution; and
discharging a second portion of the second absorbent solution from the system.

US Pat. No. 10,246,329

EXTENDED THERMAL STAGE SULFUR RECOVERY PROCESS

SAUDI ARABIAN OIL COMPANY...

1. A process for recovering sulfur in a sulfur recovery unit, the process comprising the steps of:introducing an acid gas feed to a reaction furnace, where the acid gas feed comprises hydrogen sulfide;
introducing a fuel gas to the reaction furnace;
introducing air feed to the reaction furnace, where the air feed comprises oxygen;
reacting the hydrogen sulfide and oxygen in the reaction furnace at a minimum reaction temperature to produce a reaction effluent, where the reaction effluent comprises elemental sulfur and sulfur dioxide, where the reaction effluent is at the minimum reaction temperature;
introducing the reaction effluent to a wasteheat stage of an extended boiler stage;
reducing the temperature of the reaction effluent from the minimum reaction temperature to a boiler section outlet temperature to produce a cooled effluent, where the cooled effluent comprises hydrogen sulfide, sulfur dioxide, and sulfur-containing contaminants, where the temperature of the reaction effluent is reduced by capturing heat energy;
introducing the cooled effluent to a catalytic extension of the extended boiler stage, where the catalytic extension comprises a catalyst, where the catalytic extension has a gross hourly space velocity between 3000 h?1 and 6000 h?1;
reacting the hydrogen sulfide, sulfur dioxide, and sulfur-containing contaminants in the catalytic extension to produce a boiler catalytic effluent, where the boiler catalytic effluent comprises elemental sulfur, where the boiler catalytic effluent is at a boiler catalytic effluent temperature;
introducing the boiler catalytic effluent to a condenser, where the boiler catalytic effluent comprises elemental sulfur;
reducing the boiler catalytic effluent temperature such that the elemental sulfur condenses to form liquid sulfur and a gases stream;
introducing the gases stream to a thermal oxidizer, where the gases stream comprises hydrogen sulfide and sulfur-containing contaminants;
introducing an air stream to the thermal oxidizer, where the air stream comprises oxygen;
reacting the hydrogen sulfide and sulfur-containing contaminants with the oxygen to produce an oxidizer outlet stream, where the oxidizer outlet stream comprises sulfur dioxide;
introducing the oxidizer outlet stream to a scrubbing unit; and
separating the sulfur dioxide in the scrubbing unit to produce a recycle stream and an effluent gases, where the recycle stream comprises sulfur dioxide.

US Pat. No. 10,246,328

HIGH EFFICIENCY PROCESS FOR DEGASSING OF HYDROGEN SULFIDE FROM LIQUID SULFUR

WorleyParsons Europe Ltd....

1. A process for degassing liquid sulfur, the process comprising:mixing a gas with a liquid sulfur mixture comprising sulfur, hydrogen sulfide, and hydrogen polysulfides to form a sulfur-gas mixture;
transporting the sulfur-gas mixture to a separator, storage vessel or storage tank;
separating the sulfur-gas mixture at a pressure below a water condensation point to recover a degassed sulfur product and a vapor stream comprising hydrogen sulfide;
wherein mixing gas with the liquid sulfur mixture comprises:
introducing the gas into a suction of a sulfur transfer pump used for transporting the liquid sulfur mixture to the separator, storage vessel or storage tank;
introducing the gas into a transfer line during transport of the liquid sulfur mixture to the separator, storage vessel or storage tank; or
a combination thereof.

US Pat. No. 10,246,327

MULTI-CHAMBER HYPOCHLOROUS ACID DISPENSER

WIAB WATER INNOVATION AB,...

1. A system for storing and producing hypochlorous acid (HOCl), the system comprising:a container from which air has been purged, the container comprising a first compartment, a second compartment, a third compartment, and a fourth compartment, wherein the first compartment contains a compound that generates a hypochlorite anion (OCl—) in the presence of water, the second compartment contains a compound that generates a proton (H+) in the presence of water, and the third compartment contains water;
a first one-way valve that permits fluid flow from the first compartment to the fourth compartment;
a second one-way valve that permits fluid flow from the second compartment to the fourth compartment; and
a third one-way valve that permits fluid flow from the third compartment to the fourth compartment.

US Pat. No. 10,246,326

STEAM REFORMING

Johnson Matthey Public Li...

17. A process for steam reforming hydrocarbons, comprising the steps of:(i) passing a feed gas mixture, comprising hydrocarbon and steam through the plurality of externally-heated vertical tubes disposed within the steam reformer of claim 1, and
(ii) recovering a reformed gas mixture from the tubes.

US Pat. No. 10,246,325

MEMS DEVICE AND METHOD FOR MANUFACTURING A MEMS DEVICE

Infineon Technologies AG,...

1. A method for producing a MEMS device, comprising:forming a semiconductor layer stack, the semiconductor layer stack comprising at least a first monocrystalline semiconductor layer, a second monocrystalline semiconductor layer, a third monocrystalline semiconductor layer, a fourth monocrystalline semiconductor layer, and a fifth monocrystalline semiconductor layer, the second monocrystalline semiconductor layer formed between the first and third monocrystalline semiconductor layers, the first monocrystalline semiconductor layer being formed above the fourth monocrystalline semiconductor layer and the fifth monocrystalline semiconductor layer being formed above the third monocrystalline semiconductor layer, wherein a semiconductor material of the second monocrystalline semiconductor layer is different from semiconductor materials of the first and third monocrystalline semiconductor layers, at least one layer of the semiconductor layer stack includes a compound semiconductor material and at least one layer of the semiconductor layer stack includes a non-compound semiconductor material, and adjacent layers of the first, the second, and the third monocrystalline semiconductor layers have mutual different doping types;
etching the first, the second, the third, and the fifth monocrystalline semiconductor layers to form channels extending from the fifth monocrystalline semiconductor layer to the first monocrystalline semiconductor layer and terminating within the first monocrystalline semiconductor layer;
etching, via the channels, the first and the third monocrystalline semiconductor layers, wherein a movable first portion of the second monocrystalline semiconductor layer forming a movable MEMS element is released by removing a first portion of the first monocrystalline semiconductor layer and a first portion of the third monocrystalline semiconductor layer, second and third portions of the first monocrystalline semiconductor layer remaining below respective second and third portions of the second monocrystalline semiconductor layer, and second and third portions of the third monocrystalline semiconductor layer remaining above the second and the third portions of the second monocrystalline semiconductor layer, the movable first portion of the second monocrystalline semiconductor layer being separated laterally by gaps defined by the channels and vertically by gaps defined by the removed first portion of the first monocrystalline semiconductor layer between the fourth monocrystalline semiconductor layer and the second monocrystalline semiconductor layer and the removed first portion of the third monocrystalline semiconductor layer between the second monocrystalline semiconductor layer and the fifth monocrystalline semiconductor layer; and
providing a monocrystalline semiconductor material in a portion of the channels within the fifth monocrystalline semiconductor layer to seal the channels.

US Pat. No. 10,246,321

MEMS DEVICE, LIQUID EJECTING HEAD, LIQUID EJECTING APPARATUS, METHOD FOR MANUFACTURING MEMS DEVICE

Seiko Epson Corporation, ...

1. A MEMS device comprising:a substrate having a resin portion that protrudes from one surface thereof and is made of a resin and a first wiring that covers at least a portion of a surface of the resin portion,
wherein the first wiring extends along a first direction on the one surface from a position overlapping the resin portion to a position deviating from the resin portion, and
wherein a width of the resin portion is equal to or larger than a width of the first wiring covering the resin portion in a second direction intersecting the first direction,
wherein the resin portion includes a first portion and a second portion that is adjacent to the first portion along the second direction and of which a height from the one surface is lower than that of the first portion,
wherein the first wiring is provided at a position overlapping the first portion,
wherein a width of the first portion is equal to or larger than the width of the first wiring covering the first portion in the second direction,
wherein a second wiring is between the first portion and the first wiring,
wherein a width of the second wiring is equal or larger than the width of the first wiring covering the first portion in the second direction, and
wherein the width of the second wiring is larger than the width of the first portion in the second direction.

US Pat. No. 10,246,315

IMPROVEMENTS TO HAND TRUCK AND KIT THEREOF

1. A hand truck comprising:(a) an H-beam having a length, the beam comprising:
(a1) an H-beam top; and
(a2) an H-beam bottom;
(b) a platform body sub-assembly comprising platform rollers, the platform rollers engaging the H-beam to permit the platform body sub-assembly to travel along a portion of the length of the H-beam;
(c) a plate affixed to the platform body sub-assembly to permit the plate to travel concurrently with the platform body sub-assembly, the plate being arranged substantially perpendicular to the H-beam;
(d) a strut pulley sub-assembly arranged substantially parallel to the beam, the strut pulley sub-assembly comprising:
(d1) an upper end;
(d2) a lower end;
(d3) a dampener strut comprising:
(d1A) a strut top; and
(d1B) a strut bottom;
(d4) a spring arranged substantially parallel to the dampener strut, the spring comprising:
(d4A) a spring top; and
(d4B) a spring bottom;
(d5) a strut mount mechanically connecting the strut bottom to the spring bottom; and
(d6) a pulley mount mechanically connecting the strut top to the spring top;
(e) a head sub-assembly connecting the upper end of the strut pulley sub-assembly to the beam top;
(f) a rope extending from the platform body sub-assembly to the pulley mount through the head sub-assembly, the rope connecting the platform body sub-assembly to the pulley mount; and
(g) a total unloaded weight of less than twenty-three kilograms (23 kg).

US Pat. No. 10,246,314

WIRE LOCKING STRUCTURE FOR BOOM EXTENSION

TADANO LTD., Kagawa (JP)...

1. A boom-extending wire locking structure that locks an extending wire in an extendable boom, the extendable boom comprising:a first boom member;
a second boom member that is extendable with respect to the first boom member;
a third boom member that is extendable with respect to the second boom member;
an extending wire that couples a base end side of the first boom member and a base end side of the third boom member; and
an extending sheave provided at a leading end side of the second boom member with a part of the extending wire wound around the extending sheave, the extending sheave being configured to cause a movement of the third boom member with respect to the second boom member in an extending direction by moving a coupling part of the extending wire on the third boom member side in the extending direction along with a movement of the second boom member with respect to the first boom member in the extending direction, wherein:
the extending wire includes a plurality of wire members, each of the wire members including a plurality of pairs of stretched parts stretched between the base end side of the first boom member and the base end side of the third boom member, and a lock part that is interposed between adjacent pairs of the stretched parts and locked at at least one of the base end side of the first boom member and the base end side of the third boom,
a wire locking tool that locks the extending wire by winding the lock part of each wire member is provided at at least one of the base end side of the first boom member and the base end side of the third boom member,
the wire locking tool includes a pair of fixing pieces provided on both sides in an orthogonal direction orthogonal to the extending direction and fixed to at least one of the first boom member and the third boom member, and a plurality of wire locking parts provided between the pair of fixing pieces, the wire locking parts including grooves for winding the respective lock parts of the wire members, each of the grooves having an arc shape, and
the plurality of wire locking parts are arranged in a central axis direction of the arc shape between the pair of fixing pieces, and central axes of the wire locking parts are arranged at different positions in the orthogonal direction from respective adjacent wire locking parts.

US Pat. No. 10,246,311

WINCH

Liebherr-Components Biber...

1. A winch, comprising:a winch drum arranged on a drum shaft;
at least one main drive driving the drum shaft, the main drive arranged coaxially with the winch drum on the drum shaft; and
at least one emergency drive driving the drum shaft in case of emergency, the emergency drive comprising a drive wheel,
wherein at least one emergency drive is coupleable to a driven wheel of the drum shaft as required via at least one intermediate gear, the intermediate gear in constant engagement with the emergency drive, via the drive wheel, independent of a current position of the intermediate gear and shiftably mounted for coupling in and out in a direction of its shaft axis, the driven wheel arranged on the drum shaft between the winch drum and the main drive.

US Pat. No. 10,246,310

LARGE MOBILE CRANE

TEREX GLOBAL GMBH, Schaf...

1. Large mobile crane comprising an undercarriage, wherein the undercarriage comprises a middle section between tracks, wherein a distance between the tracks can be increased or decreased by the insertion or removal of expansion parts, said two tracks connected on opposite sides of the undercarriage to permit movement of the large mobile crane, a drive unit, a superstructure, one or more control stations, at least two main booms, at least one derrick boom, and at least two lifting devices and counterweights, wherein said counterweights are either arranged separately of or mounted on the undercarriage, and wherein the large mobile crane further comprises a circular track, and support rollers attached to the superstructure, wherein the support rollers ride on the circular track, and wherein the circular track is an integral part of the expansion parts.

US Pat. No. 10,246,309

OPTICAL MEASUREMENT DEVICE, LOAD HANDLING APPARATUS, METHOD FOR PROTECTING OPTICAL MEASUREMENT DEVICE AND METHOD FOR UPDATING LOAD HANDLING APPARATUS

1. A load handling apparatus comprising:an optical measurement device comprising:
a permeable surface configured to communicate light to and from the optical measurement device; and
a hydrophilic coating arranged on the permeable surface, wherein the coating is a nanotechnical product comprising nanostructured TiO2 in anatase form,
wherein the optical measurement device is configured to transmit light through the permeable surface and receive reflections of the transmitted light through the permeable surface,
a drive system; and
a controller operatively connected to the drive system and the optical measurement device, and configured to:
obtain measurement information from the optical measurement device; and
drive the load handling apparatus on the basis of the measurement information.

US Pat. No. 10,246,307

HARDTOP REMOVAL BRACKET AND METHODS OF USE THEREOF

1. A device comprising:a base; and
an arm with an eye;
wherein said base has a first hole there through; said base has a second hole there through; wherein said first hole has a first hole neck; said second hole has a second hole neck; wherein said first hole neck has a first hole neck width; said first hole has a first hole width; said first hole width is larger than said first hole neck width; wherein said first hole is generally slot shaped and has a first hole through axis; said second hole is generally slot shaped and has a second hole through axis; wherein said eye has an eye axis; said first hole through axis is generally parallel to said second hole through axis; and said eye axis is generally perpendicular to said first hole through axis and to said second hole through axis.

US Pat. No. 10,246,303

ARRANGEMENT AND ELEVATOR

KONE CORPORATION, Helsin...

1. An arrangement for guiding belt-shaped ropes of an elevator comprising:a plurality of belt-shaped ropes;
a rope wheel deck comprising a frame mounted on a structure of an elevator, a plurality of rope wheels for guiding ropes of the elevator, and a plurality of bearings, wherein the rope wheels are cambered and mounted coaxially on the frame via the bearings such that they are rotatable relative to the frame as well as relative to each other; and
a hollow cylinder surrounding the central shaft, a wall of the hollow cylinder being radially between the rope wheels and the central shaft,
wherein only one belt-shaped rope passes around each of said rope wheels of the rope wheel deck, and the plurality of bearings comprise a bearing which is radially between each of the rope wheels and the cylinder and supports each and every one of the rope wheels such that all of the rope wheels are rotatable relative to the hollow cylinder.

US Pat. No. 10,246,298

ROPELESS ELEVATOR SYSTEM

OTIS ELEVATOR COMPANY, F...

1. An elevator system comprising:a hoistway including a first hoistway portion and a second hoistway portion;
a first car disposed within the first hoistway portion;
a first stationary stator disposed in the first hoistway portion;
a second stationary stator disposed in the second hoistway portion;
a first mover mounted on the first car, the first car propelled in the first hoistway portion by only the interaction of the first mover with the first stationary stator the first car propelled in the second hoistway portion by only the interaction of the first mover with the second stationary stator; and
a first guiderail disposed in the first hoistway portion, wherein the first hoistway portion is free of other guiderails;
the first car has a first side and a second side, the second side opposite to the first side, wherein the first mover is mounted to the first side and a first guide portion is mounted to the second side of the first car, the first guide portion configured to interact with the first guiderail when the first car is disposed in the first hoistway portion.

US Pat. No. 10,246,295

PROTECTIVE DEVICE FOR SPEED SENSING DEVICE

OTIS ELEVATOR COMPANY, F...

1. An elevator system having a safety actuation assembly comprising:a housing;
a speed sensing device for sensing the speed of the elevator system disposed within the housing, wherein the speed sensing device comprises a proximal end; and
a protection device disposed within the housing and located adjacent to the proximal end of the speed sensing device;
wherein the protection device configured to be placed in a first position when in a non-engaging position and a second position when in an engaging position.

US Pat. No. 10,246,292

YARN CLEARER AND SPINNING STATION, EQUIPPED THEREWITH, OF A SPINNING MACHINE, AND METHOD FOR OPERATING A SPINNING STATION

Maschinenfabrik Rieter AG...

1. A spinning station of a spinning machine, comprising:a spinning means for producing a yarn from a sliver fed to the spinning means;
a winding apparatus that winds the yarn from the spinning means onto a package, the winding apparatus arranged downstream of the spinning means in a transport direction of the yarn;
a yarn clearer arranged between the spinning means and the winding apparatus, the yarn clearer configured to monitor for yarn defects in the yarn prior to the yarn being wound onto the package;
a controller in communication with the yarn clearer and configured to interrupt production of the yarn upon detection of a defined yarn defect by the yarn clearer; and
an information unit in communication with the controller and disposed so as to be visible to an operator of the spinning station, the information unit comprising a display that, prior to yarn being unwound from the package, visibly informs the operator of a minimum yarn length to subsequently unwind from the package following the interruption of yarn production in order to ensure that the yarn defect will be completely removed from the package.

US Pat. No. 10,246,290

CONVEYING APPARATUS AND TRAY UNIT

BROTHER KOGYO KABUSHIKI K...

1. A conveying apparatus, comprising:a plurality of receiving trays each having a receiving surface that receives a medium, the plurality of receiving trays being arranged in a vertical direction, the plurality of receiving trays comprising (i) a lowest tray located at a lowest position among the plurality of receiving trays and (ii) a first receiving tray that is each of at least one of the plurality of receiving trays and the at least one of the plurality of receiving trays does not include the lowest tray;
a conveying mechanism configured to convey the medium to the receiving surface of one of the plurality of receiving trays, selectively;
a supporter supporting the plurality of receiving trays;
a swing mechanism configured to swing the first receiving tray with respect to the supporter so as to move the first receiving tray selectively to one of a receiving position at which the first receiving tray receives the medium conveyed by the conveying mechanism and an upper position at which a position of a downstream end of the first receiving tray in a conveying direction in which the medium is conveyed by the conveying mechanism is higher than a position of the downstream end of the first receiving tray located at the receiving position,
a position-keeper configured to keep the first receiving tray at the upper position when a first external force that is an external force directed in a direction in which the first receiving tray is moved from the upper position toward the receiving position is not applied to the first receiving tray located at the upper position,
wherein the swing mechanism is configured to swing the first receiving tray with respect to the supporter toward the receiving position when the first external force is applied to the first receiving tray, and
wherein the conveying apparatus further comprises a force-reducer configured to reduce a keeping force, of the position-keeper, so as to cease keeping the first receiving tray at the upper position,
wherein the conveying apparatus further comprises:
a recorder configured to perform recording on the medium conveyed by the conveying mechanism; and
a controller configured to, when a recording command for instructing the recorder to perform recording is received, control the position-keeper to move a destination receiving tray of the plurality of receiving trays from the upper position to the receiving position, the destination receiving tray being located at the upper position and serving as a destination to which the medium is to be conveyed by the conveying mechanism.

US Pat. No. 10,246,289

BANKNOTE STORAGE UNIT

Innovative Technology Lim...

1. A banknote storage unit comprising:a first tape reel banknote storage device;
a second tape reel banknote storage device; and
a drive transmission means moveable between engagement with said first tape reel banknote storage device and engagement with said second tape reel banknote storage device.

US Pat. No. 10,246,288

MEDIUM WINDING DEVICE

Oki Data Corporation, To...

1. A medium winding device for winding a medium, comprising:a rotatable winding-member;
a driver configured to rotate the winding member to wind the medium around the winding member into a roll;
a rotating friction member rotatably disposed upstream of the winding member in a conveying direction in which the medium is conveyed, the rotating friction member having a high friction member forming an outer surface of the rotating friction member, and being configured to apply tension to the medium when the medium is wound around the winding member; and
a tension adjusting member connected to the rotating friction member and configured to maintain the tension applied to the medium to be constant, by applying a constant load to the rotating friction member.

US Pat. No. 10,246,285

WEB ROLL HANDLING AND LOADING SYSTEM

The Boeing Company, Chic...

1. A roll handling and loading system for a roll of web material comprising web material wound on a hollow tubular core, the roll of web material having a horizontally-oriented length, the system comprising:a frame having a horizontally-oriented space between opposing sides of the frame;
a pair of hubs positioned on the opposing sides of the frame, each of the hubs mounted on a movable bar for moving the movable bar and the hubs in a vertical direction relative to the frame, at least one of the hubs comprising a compression spring positioned within the at least one of the hubs along a horizontal rotational axis to provide an inward force toward the roll of web material, and each of the hubs pivotably supported on a pivot mechanism for pivoting movement between an operational position on the horizontal rotational axis and a deflected position in which a hub face of each of the hubs is deflected in an arcuate direction away from the horizontal rotational axis.

US Pat. No. 10,246,282

DRIVE TRANSMISSION DEVICE AND IMAGE FORMING APPARATUS

KYOCERA Document Solution...

1. A drive transmission device that transmits driving force of a motor to a roller via a plurality of drive trains, the drive transmission device comprising:a controller;
a first drive train including a one-way clutch; and
a second drive train that is different from the first drive train and includes an electromagnetic clutch, wherein
the first drive train receives the driving force from the motor and transmits the driving force to the second drive train,
the second drive train transmits the driving force from the first drive train to the roller,
the controller switches a rotational speed of the roller by switching on/off the electromagnetic clutch,
the first drive train includes a first gear, a second gear, and a rotary shaft to which the first gear and the second gear are connected via the one-way clutch,
the first gear and the second gear each have teeth on an outer circumferential surface thereof,
the number of the teeth of the first gear is a first teeth number and the number of the teeth of the second gear is a second teeth number that is different from the first teeth number,
the second drive train includes a third gear, a fourth gear, and a rotary shaft to which the third gear and the fourth gear are connected via the electromagnetic clutch,
the third gear engages the first gear,
the third gear and the fourth gear each have teeth on an outer circumferential surface thereof, and
the number of the teeth of the third gear is a third teeth number and the number of the teeth of the fourth gear is a fourth teeth number that is different from the third teeth number.

US Pat. No. 10,246,281

SHEET CONVEYING APPARATUS

Brother Kogyo Kabushiki K...

1. A sheet conveying apparatus, comprising:a supporter comprising a support surface configured to support a plurality of sheets;
a supplier comprising a supply roller rotatable about a rotation axis, the supply roller comprising an outer circumferential surface partly exposed from the support surface and configured to supply one or more sheets supported by the support surface toward a downstream side in a conveying direction along a conveyance path by rotating in contact with the one or more sheets supported by the support surface in a direction for supplying the one or more sheets in the conveying direction;
a separator disposed downstream of the supplier in the conveying direction and configured to separate, at a nip position thereof, one by one the one or more sheets supplied by the supplier and convey the separated sheet toward the downstream side in the conveying direction;
a stopper disposed upstream of the nip position of the separator in the conveying direction and pivotable, about a first axis that is located opposite to the rotation axis of the supply roller relative to the support surface, between (i) a first position at which a distal end portion of the stopper extends to the support surface intersects the conveyance path and stops the plurality of sheets supported by the support surface, and (ii) a second position at which the distal end portion is separated from the support surface and is located more downstream in the conveying direction than at the first position, wherein the distal end portion has a downstream surface facing downstream in the conveying direction;
a stopper cam disposed upstream of the nip position of the separator in the conveying direction, having a contact surface facing upstream in the conveying direction, and pivotable, about a second axis that is located opposite to the first axis relative to the support surface, between (a) a third position at which the contact surface of the stopper cam is in contact with the downstream surface of the distal end portion of the stopper located at the first position to restrict pivoting of the stopper toward the second position, and (b) a fourth position at which the contact surface of the stopper cam is spaced apart from the downstream surface of the distal end portion of the stopper to allow pivoting of the stopper from the first position toward the second position; and
an inclined surface disposed upstream of the nip position of the separator in the conveying direction and pivotable, about a third axis that is located opposite to the rotation axis of the supply roller relative to the support surface, between an initial position and a pivoted position,
wherein the second axis of the stopper cam is located upstream of the rotation axis of the supply roller in the conveying direction and farther from the support surface than the rotation axis of the supply roller,
wherein when the stopper cam is located at the third position, the inclined surface is located at the initial position and out of contact with the plurality of sheets stopped by the stopper located at the first position, and
wherein when the stopper cam pivots from the third position toward the fourth position, the inclined surface is pushed toward the pivoted position by the plurality of sheets released from the stopper.

US Pat. No. 10,246,280

SHEET FEED DEVICES AND IMAGE RECORDING APPARATUS COMPRISING SUCH SHEET FEED DEVICES

Brother Kogyo Kabushiki K...

1. A sheet feed device comprising:a tray comprising:
a holding surface configured to hold a plurality of sheets;
a pair of side guides extending in a sheet feed direction and configured to guide opposite side edges of the plurality of sheets held on the holding surface; and
a rack and pinion mechanism comprising racks each connected to a corresponding one of the side guides and a pinion located at a center of the holding surface in a width direction perpendicular to the sheet feed direction, the racks being engaged with the pinion such that the side guides are slidable relative to the pinion,
a feed unit configured to contact a particular sheet of the plurality of sheets held by the holding surface of the tray and feed at least the particular sheet in the sheet feed direction; and
a separation unit disposed downstream of the holding surface in the sheet feed direction and configured to separate the particular sheet from other sheets of the plurality of sheets, the separation unit comprising:
first and second inclined surfaces immovably inclined relative to the holding surface and configured to guide the particular sheet fed by the feed unit;
a plurality of first projections arrayed in alignment with the pinion of the tray in the sheet feed direction and projecting in a projecting direction toward the feed unit relative to the first and second inclined surfaces;
a metal elastic member configured to urge the plurality of first projections in the projecting direction toward the feed unit from an opening formed between the first and second inclined surfaces;
a plurality of second projections each having a first sloping surface and a second sloping surface that are different in steepness relative to the first inclined surface, the plurality of second projections being arrayed in the sheet feed direction and projecting toward the feed unit relative to the first inclined surface that extends between and parallel to the arrayed first projections and the arrayed second projections; and
a plurality of third projections each having a first sloping surface and a second sloping surface that are different in steepness relative to the second inclined surface, the plurality of third projections being arrayed in the sheet feed direction and projecting toward the feed unit relative to the second inclined surface that extends between and parallel to the arrayed first projections and the arrayed third projections,
wherein the metal elastic member is disposed separate from the first and second inclined surfaces, the plurality of second projections, and the plurality of third projections, and the first and second inclined surfaces are closer to the feed unit in the projecting direction than the metal elastic member is to the feed unit.

US Pat. No. 10,246,277

SYSTEM AND APPARATUS FOR PRINT MEDIA MANUFACTURING BUFFERING AND SORTING, AND CORRESPONDING METHOD THEREOF

Lightning Source LLC, La...

1. An apparatus for performing at least one of buffering and sorting during a print media assembly or delivery operation, the apparatus comprising:an enclosure;
a storage section within the enclosure;
an input section configured to receive at the enclosure at least a portion of a printed element;
a gripper associated with the input section, the gripper configured to selectively transport the at least a portion of the printed element from the input section to the storage section and to selectively transport the at least a portion of the printed element from the storage section within the enclosure; and
an output section configured to selectively transfer the at least a portion of the printed element from the enclosure,
wherein the storage section comprises at least one segment having a plurality of ridges and valleys, the segment configured to store thereupon the at least a portion of the printed element.