US Pat. No. 10,188,841

CAPSULE-TYPE MICROROBOT AND USING METHOD THEREOF

Daegu Gyeongbuk Institute...

1. A capsule-type microrobot comprising:a motor comprising a receptacle having an internal space, with one portion thereof being open, a body extending from the receptacle, and a magnetic layer disposed on an outer surface of the body; and
a cap coupled to a predetermined portion of the receptacle to close the internal space such that contents are contained in the receptacle, the cap being of different weight than the motor,
wherein the motor is magnetically-rotatable via a rotating magnetic force in a first direction so as to move the microrobot; and wherein the motor is magnetically-rotatable via the rotating magnetic force in a second direction so as to separate the cap from the motor, whereby the contents are discharged from the receptacle.

US Pat. No. 10,188,838

TEXTILE-REINFORCED HIGH-PRESSURE BALLOON

Cook Medical Technologies...

1. A process of making a textile-reinforced medical dilation balloon, said process comprising the steps of:constructing a seamless woven tubular textile sleeve including substantially longitudinal warp threads and at least one high-modulus weft thread woven helically along a winding pitch that is substantially perpendicular relative to the warp threads,
such that every at least one weft thread extends around, through, and along the length of the sleeve with the warp threads and unidirectionally helically between and from a proximal neck portion to a distal neck portion along an identical winding pitch at an identical angle relative to the warp threads, or
such that every at least one weft thread extends around, through, and along a length of the sleeve and unidirectionally helically between and from a distal neck portion to a proximal neck portion along an identical winding pitch at an identical angle relative to the warp threads,
and wherein the sleeve defines a sleeve lumen;
directing a medical dilation balloon disposed on an inflation catheter into the sleeve lumen; and
heating a portion of the balloon and/or of the sleeve sufficiently to thermally bond the sleeve to the inflation catheter.

US Pat. No. 10,188,833

GUIDE CATHETER WITH STEERING MECHANISMS

Medtronic Vascular, Inc.,...

1. An endovascular guide catheter comprising:a flexible guide tube having a distal end portion configured to deflect via actuation of a pull wire; and
a handle coupled to the guide tube and comprising a steering assembly configured to actuate the pull wire to deflect the distal end portion of the guide tube, the steering assembly comprising:
a stationary rack;
a gear engaging the rack;
a reel coupled to and configured to rotate with the gear, the pull wire being coupled to the reel such that rotation of the reel causes the pull wire to wind or unwind around the reel;
a slider adapted for translation relative to the rack, wherein translation of the slider translates the reel relative to the rack and rotation of the gear along the rack rotates the reel; and
an actuator disposed at a distal end of the handle, the actuator is configured to rotate about a longitudinal axis of the guide catheter to drive the translation of the slider relative to the rack, wherein the actuator is externally disposed about and coupled to a threaded rod, and wherein the threaded rod is configured for translational movement and is coupled to the slider at a proximal end portion.

US Pat. No. 10,188,832

STEERABLE DELIVERY SHEATHS

Shifamed Holdings, LLC, ...

1. A steerable medical delivery device, comprising:a steerable portion comprising
a first tubular member comprising a flexible polymeric tubular member that comprises a wall of solid material along the steerable portion, the first tubular member configured to preferentially bend, and
a second tubular member, wherein one of the first and second tubular members is disposed within the other, wherein the first and second tubular members are permanently axially fixed relative to one another at a fixation location distal to the steerable portion; and
an external controller with an actuator that is adapted to be actuated, the actuator and the first and second tubular members operably coupled such that actuation of the actuator puts one of the first tubular member and the second tubular member in tension and the other of the first tubular member and the second tubular member in compression, and wherein the first and second tubular members are adapted such that the steerable portion is steered in a first direction when the actuator is actuated.

US Pat. No. 10,188,830

VACUUM TREATMENT ARRAY AND FILM FOR PRODUCING A VACUUM TREATMENT ARRAY

1. A negative pressure treatment arrangement comprising:a flexible, negative pressure-stable, drainage tube forming at least one channel-shaped lumen;
at least one open-cell fluid-collecting element through which a negative pressure is capable of being generated in a body cavity and fluids and gases are capable of being collected, the fluid-collecting element having, at least in part, an outer boundary area and an inner boundary area that encircle a tubular axis and;
wherein the fluid-collecting element is connected to the drainage tube such that the fluid-collecting element is in fluid communication with the channel-shaped lumen of the drainage tube; and
wherein the fluid-collecting element and the drainage tube are structurally interconnected such that the outer boundary of the fluid-collecting element and the drainage tube have the same diameter and continuously merge into each other such that no part of the drainage tube extends into the fluid-collecting element.

US Pat. No. 10,188,829

CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

Medtronic Ardian Luxembou...

1. A method for treating a human patient, the method comprising:advancing a neuromodulation element of a neuromodulation catheter along a transradial approach to a target site within a renal artery of the patient, wherein the neuromodulation element is at a distal end portion of a shaft of the neuromodulation catheter, and wherein the shaft includes two or more first cut shapes and two or more second cut shapes interspersed along a helical path extending about a longitudinal axis of the shaft;
applying torsion to the shaft about the longitudinal axis while advancing the neuromodulation element, wherein the first cut shapes, to a greater extent than the second cut shapes, resist deformation of the shaft in response to the torsion;
operating the neuromodulation element to modulate one or more nerves proximate a wall of the renal artery;
withdrawing the neuromodulation element along the transradial approach after operating the neuromodulation element; and
applying tension to the shaft along the longitudinal axis while withdrawing the neuromodulation element, wherein the second cut shapes, to a greater extent than the first cut shapes, resist deformation of the shaft in response to the tension.

US Pat. No. 10,188,828

MEDICAL DEVICES, METHODS, AND KITS FOR DELIVERING MEDICATION TO A BODILY PASSAGE

Cook Medical Technologies...

1. A medical device for treating a sinus cavity, the medical device comprising:a cannula defining a cannula lumen extending between a first cannula opening and a second cannula opening;
a catheter having at least a portion disposed in the cannula lumen, the catheter having a catheter proximal end, a catheter distal end, a catheter length extending between the catheter proximal end and the catheter distal end, and defining a first catheter opening, a second catheter opening, a first bend, a coil, and a catheter lumen extending between the first catheter opening and the second catheter opening;
a coating disposed on the catheter; and
a pusher having a pusher proximal end and a pusher distal end slidably disposed in the cannula lumen and adapted to engage with the catheter proximal end to transfer axial movement to the catheter;
wherein the catheter is adapted to move between a first configuration in which the portion of the catheter disposed within the cannula lumen is substantially straight when disposed in the cannula lumen and a second configuration in which the catheter defines the first bend and the coil along the catheter length when the catheter is free of the cannula lumen.

US Pat. No. 10,188,826

CATHETERS INCLUDING ANTIMICROBIAL SLEEVE AND METHODS OF MAKING CATHETERS

Covidien LP, Mansfield, ...

1. A catheter, comprising:a tubular body having an outer surface;
a hub disposed on the outer surface of the tubular body;
a tissue in-growth cuff disposed on the outer surface of the tubular body distal to the hub; and
a sleeve disposed on only a portion of the outer surface of the tubular body between the hub and the cuff, the sleeve comprising an outer layer co-extruded on an inner layer, the catheter comprising a water-soluble, anti-microbial agent contained only in the outer layer of the sleeve,
wherein the inner layer has a thickness at least about three times the thickness of the outer layer to reduce swelling of the sleeve and anchor the outer layer.

US Pat. No. 10,188,825

HUMIDIFIER FOR A RESPIRATORY ASSISTANCE DEVICE, A RESPIRATORY ASSISTANCE DEVICE AND RELATED METHODS AND APPARATUS

1. A humidifier for a respiratory assistance device, the humidifier comprising:a chamber configured to contain liquid to be evaporated,
a metallic or carbon-based material configured to be in contact with the liquid,
a mixer or agitator,
an electric or magnetic field generator configured to generate an electric or magnetic field inside the chamber so as to control movement or positioning or speed of the metallic or carbon-based material,
wherein the humidifier is configured such that, in use, at least a portion of an inside of the chamber is exposed to light such that light impinges on the metallic or carbon-based material to generate localised heating of liquid molecules around the metallic or carbon-based material and generate vapour for use by the respiratory assistance device.

US Pat. No. 10,188,820

RESPIRATORY APPARATUS

ResMed Limited, (AU)

1. A foam cushion assembly for a patient interface, the foam cushion assembly being adapted to couple with a patient interface frame, the foam cushion assembly comprising at least a nose seal portion, wherein the foam cushion assembly comprises:a foam cushion arranged for sealing about at least the nose of a patient, and
a cushion support component arranged to couple to the foam cushion, wherein the cushion support component is characterised by a height to thickness ratio of at least 3, around at least a portion of a periphery of the foam cushion,
wherein the cushion support component forms an inwardly overhanging peripheral lip for mounting the foam cushion.

US Pat. No. 10,188,817

SPEAKING VALVE

1. A speaking valve for laryngectomized and tracheotomized persons with a housing with a proximal first opening and a distal second opening, a filter which is at least partially surrounded by the housing, which filter is made of an elastic material, with a proximal first end and a distal second end, wherein the filter partially protrudes beyond an end face of the housing at the distal second opening, the housing having at least one flange extending outwardly from an outer wall of the housing to act as an enlarging aid and wherein a cover is connected by means of at least one partial region of its bottom surface to an upper side of the filter at its distal second end, whereby a diameter d1 of the cover is greater than a diameter d2 of the filter, so that an edge is formed that is protruding beyond a lateral filter wall of the filter, wherein by application of pressure onto the cover from an initial position, a lower surface of the edge of the cover at least partially interacts with the end face and the flange of the housing in order to produce a closed position of the speaking valve, and wherein the cover together with the filter returns to the initial position when unloaded.

US Pat. No. 10,188,814

COMBINATION ANESTHESIA AND SCAVENGER SURGICAL MASK

13. A surgical mask assembly for administering and scavenging medical gases, comprising:an outer shell having a first gas port configured to be coupled to a negative pressure source, the outer shell defining a chamber with a rear-facing opening defined by a rim, and
an inner shell secured to the outer shell, the inner shell defining a chamber with a rear-facing opening defined by a rim and having a second gas port that includes (i) a distal end configured to be coupled to a positive pressure source, and (ii) a proximal end that opens into the chamber of the inner shell for supplying gas from the positive pressure source to the chamber of the inner shell, wherein (i) the rim of the inner shell is enveloped by the outer shell, (ii) the inner shell is configured to deliver gas to the patient's nose, but not envelop the patient's mouth, when the surgical mask assembly is positioned on the face of the patient, and (iii) the outer shell is configured to envelope both the patient's nose and mouth when the surgical mask assembly is positioned on the face of the patient.

US Pat. No. 10,188,812

NOSE CLIP

Dean M. Toriumi, Riversi...

1. A nose clip for clipping to a nose, the nose clip comprising:an outer support member configured to overlay a contour of an outside surface of the nose;
a pin connected to the outer support member and configured to pierce a side of the nose;
an inner support member configured to engage the pin and press against an outer lateral sidewall of the nasal cavity and distribute a force against the outer lateral sidewall to shape a contour of the outer lateral sidewall of the nasal cavity of the nose, wherein in a longitudinal direction, the inner support member follows a portion of an inner circumference of the nasal cavity defined between the outer lateral sidewall and the nasal septum; and
the outer support member, inner support member and pin member cooperating to increase a width of the nasal cavity to allow more air to flow through the nasal cavity.

US Pat. No. 10,188,811

NASAL SPRAY DEVICE

IVAX PHARMACEUTICALS IREL...

1. A nasal spray device for the delivery of a pharmaceutical formulation to a nasal cavity in metered doses, the nasal spray device comprising:a pressurised aerosol canister including a vial containing a pharmaceutical formulation comprising an active ingredient, and a propellant, the aerosol canister further including a metering valve having a valve stem; and
an actuator for the aerosol canister, the actuator including a stem block having a receptacle into which the valve stem of the metering valve of the aerosol canister is received and axially located, the valve stem being displaceable relative to the vial of the aerosol canister to actuate the metering valve of the aerosol canister, a sump extending below the receptacle, the stem block further defining a cylindrical discharge orifice for the pharmaceutical formulation and a transfer channel through which a dispensed dose of the pharmaceutical formulation is able to pass from the sump to the cylindrical discharge orifice,
wherein the actuator further comprises a delivery outlet for an aerosol plume, the cylindrical discharge orifice being arranged to direct the aerosol plume through the delivery outlet,
wherein the nasal spray device is adapted to produce an aerosol plume for a dispensed dose having a spray force value no greater than 40 millinewtons (mN) measured at a distance of 30 millimeters (mm) from the cylindrical discharge orifice, wherein the cylindrical discharge orifice has a diameter of 0.15 to 0.65 mm and a length of 0.6 mm to 1.0 mm, and wherein the transfer channel has a length of 3 to 20 mm and has a transverse dimension in a range of 1.2 mm to 2 mm, the transverse dimension being measured at its maximum extent.

US Pat. No. 10,188,809

THERAPY-SPECIFIC MEDICAL PUMP

Zyno Medical, LLC, Natic...

1. A programmable medical pump comprising:a housing holding:
a first and second metering pump wherein
the first metering pump is a syringe pump for receiving and activating a plunger providing delivery of a predetermined first volume of a first medicament from a syringe holding a first medicament;
the second metering pump is a peristaltic pump for receiving and activating actuators controlling delivery of a predetermined second volume of a second medicament through an IV tube attached to a medicament container, the syringe volume being smaller than the medicament container volume;
a controller independently controlling the syringe pump to deliver a first predetermined volume of the first medicament at a first predetermined flow rate and the peristaltic pump to deliver a second predetermined volume of the second medicament at a second predetermined flow rate;
an electronic memory holding a multi-session treatment schedule spanning multiple days describing different treatment sessions and treatment protocols for a delivery of liquid medicament through the syringe pump and peristaltic pump for each session;
an interface display;
a start control; and
an electronic computer communicating with the interface display, start control, syringe pump and peristaltic pump, and an electronic memory executing a stored program fixed in a non-transitory medium to:
(1) identify a current session of the treatment schedule;
(2) provide an alert to a patient indicating the current session is due;
(3) determine a treatment protocol for the current session; and
(4) activate, via the start control, the treatment protocol controlling a sequential delivery of the first medicament at the first predetermined flow rate followed by the second medicament at the second predetermined flow rate for the current session for both the first and second metering pumps;
wherein the interface display communicates with the electronic computer and wherein the electronic computer executes the stored program to display, via the interface display, (i) a calendar to identify a particular session based on a calendar day of the session, (ii) step by step instructions relative to the treatment protocol requiring user intervention, and (iii) a current session of the treatment protocol.

US Pat. No. 10,188,808

FIBER OPTIC DISTAL SENSOR CONTROLLED DRUG INJECTOR

THE JOHNS HOPKINS UNIVERS...

1. A motion-compensated injector system comprising:a handheld tool comprising a hollow shaft with a distal end configured for insertion into tissue of a subject to deliver a material to a target location of the tissue of the subject through the hollow shaft;
an optical coherence tomography-based optical detection system comprising:
an optical fiber having a distal end at a fixed distance from the distal end of the hollow shaft, and
an optical sensor configured to receive a signal from the optical fiber;
an actuator integrated into the handheld tool, the actuator configured to move the hollow shaft in an axial direction, the actuator comprising a linear motor directly connected to a rod to which the hollow shaft is fixed, the linear motor driving the rod to move the hollow shaft; and
a control unit to control the actuator,
wherein the optical detection system is configured to monitor a distance between the distal end of the optical fiber and a reference portion of the tissue of the subject,
wherein the control unit controls the actuator to move the hollow shaft to compensate for relative motion between the handheld tool and the portion of the tissue,
wherein the control unit is configured to control the actuator based on a closed-loop proportional-integral-derivative control algorithm to compensate for deformation of the tissue during insertion of the hollow shaft, and
wherein the optical fiber is adjacent but not concentric to the hollow shaft.

US Pat. No. 10,188,806

DRIVE MECHANISM FOR A NEEDLE INSERTION ARRANGEMENT

Sanofi-Aventis Deutschlan...

1. A drive mechanism for a needle insertion arrangement, the drive mechanism comprising:a bistable mechanism with at least one pivoted link having two stable end positions (LEP, UEP) and an instable transitional central position (CP);
a spring biasing the at least one pivoted link out of the instable transitional central position (CP), wherein at least one trigger unit is arranged for moving the at least one pivoted link out of at least one of the stable end positions (LEP, UEP) towards and beyond the instable transitional central position (CP) against the bias of the spring; and
a forked needle retainer adapted to retain an injection needle, the forked needle retainer arranged to be linearly moved between a retracted position (RP) and an extended position (EP), wherein one end of the at least one pivoted link is adapted to abut an upper prong and a lower prong on the forked needle retainer,
wherein the upper prong is spaced from the lower prong for allowing a pre-determined free travel of the at least one pivoted link between disengaging one of the prongs and engaging the other one of the prongs.

US Pat. No. 10,188,805

TARGETING THERAPEUTIC AGENTS

Emory University, Atlant...

1. A method for targeting administration of a therapeutic agent to a subject, comprising:inserting a device including a sleeve defining a lumen and a frame disposed about an end of the sleeve into an organ lumen of an organ;
wherein the frame includes more than one arm extending from the end of the sleeve;
wherein the frame shapes a concavity into an outer wall of the organ between a first arm and a second arm of the frame;
guiding an administration device through a guide apparatus disposed on the sleeve so that the administration device is guided external to the organ lumen and the sleeve, between the first arm and the second arm, and proximate to the shaped concavity; and
administering a therapeutic agent into the shaped concavity.

US Pat. No. 10,188,804

CONTACT TRIGGER RELEASE NEEDLE GUARD

Safety Syringes, Inc., F...

1. A needle guard couplable to a syringe, the needle guard comprisinga lock collar slideably couplable to a syringe; and
a device shield transitionable from a first position in which a syringe sharp extends beyond the device shield to a second position in which the syringe sharp is covered by the device shield, the device shield comprising at least one radially deflectable retention arm,
wherein, in the first position, the lock collar and the device shield are engaged to hold the device shield in the first position against the bias of a biasing member urging the device shield toward the second position, and movement of the syringe sharp relative to the device shield disengages the device shield from the lock collar enabling the device shield to transition to the second position, and
wherein the lock collar includes at least one tab and the at least one retention arm engages the at least one tab to retain the device shield in the first position.

US Pat. No. 10,188,803

DISPOSABLE SAFE VEIN TRANSFUSION PUNCTURE NEEDLE

GEMTIER MEDICAL (SHANGHAI...

1. A disposable safe vein transfusion puncture needle, comprisinga needle head,
a needle base,
a needle sheath, sleeved on the needle head; and
a hose, communicated with the needle base,characterized in further comprisinga plurality of slidable components; and
a plurality of limiting mechanisms,
wherein,
the needle base is in a tubular shape, with one end stationary and communicated with the needle head and the other end connected to the hose;
each of the slidable components is in a tubular shape and has two open ends, the plurality of slidable components are sleeved on one another, the innermost slidable component is movably sleeved onto the needle base, and a sum of lengths of the plurality of slidable components in a moving direction is longer than the length of the needle head;
the limiting mechanisms are disposed on the plurality of slidable components as well as on the needle base and adapted for securing the innermost slidable component to the needle base as well as securing the plurality of slidable components to one another when the plurality of slidable components slide to completely shield the needle head,
the plurality of slidable components comprise a first slidable component movably sleeved on the needle base and a second slidable component movably sleeved on the first slidable component,
the limiting mechanisms comprise two elastic fasteners and four grooves, one of the elastic fasteners is disposed on the first slidable component, and the other elastic fastener is disposed on the second slidable component; two of the grooves are disposed on the needle base, and the other two grooves are circumferentially disposed on an exterior wall of the first slidable component; the elastic fasteners and the grooves are adapted for engaging with each other when the first slidable component and the second slidable component slide to completely shield the needle head or when the needle head is completely exposed, so as to limit the movement of the first slidable component and the second slidable component,
one end of the second slidable component close to the hose has a smooth projection portion circumferentially disposed thereon,
a smooth planar surface is disposed on a lateral side of the second slidable component, and the plane of the smooth planar surface forms an angle of 5°-20° with an axial line of the needle head; the second slidable component has a notch disposed on the lateral side with the smooth planar surface, and the notch is in a plane parallel to an axial line of the needle head; one end of the notch extends to an open end of the second slidable component away from the hose, and the other end of the notch extends to intersect with the smooth planar surface.

US Pat. No. 10,188,802

SHEATH REMOVAL MECHANISM

Sanofi-Aventis Deutschlan...

1. A sheath removal mechanism for removing a protective needle sheath from a medicament container, the medicament container arrangeable in a medicament delivery device, wherein the sheath removal mechanism comprises:a cap attachable to a distal end of the medicament delivery device,
wherein the cap comprises a plurality of ledges adapted to engage the protective needle sheath,
wherein the plurality of ledges is respectively arranged on a plurality of compliant sheath removal beams arranged on the cap,
wherein the plurality of ledges have a clearance therebetween that is sufficiently wide to allow a protective needle sheath to pass through the plurality of ledges when the plurality of compliant sheath removal beams is in a relaxed state, and
wherein one or more snap fits are respectively arranged on the plurality of compliant sheath removal beams in a manner such that the one or more snap fits engage one another to secure neighboring beams of the plurality of compliant sheath removal beams to each other when the plurality of compliant sheath removal beams is deflected radially inward.

US Pat. No. 10,188,801

MECHANISM FOR PREVENTING SELECTION OF A DOSE

Sanofi-Aventis Deutschlan...

1. A dose setting mechanism for use with a drug delivery device, the dose setting mechanism comprising:a dose setter for selecting a dose; and
a locking mechanism configured to prevent movement of the dose setter and selection of the dose,
wherein the locking mechanism is configured such that inserting a correct cartridge into the drug delivery device unlocks the locking mechanism so as to allow movement of the dose setter and selection of the dose, and
wherein the locking mechanism is configured such that inserting an incorrect cartridge into the drug delivery device locks the locking mechanism so as to prevent the dose setter from setting a dose, wherein the locking mechanism prevents the dose setter from rotating, and wherein, when the correct cartridge is inserted into the drug delivery device, the locking mechanism unlocks so as to allow the dose setter to rotate.

US Pat. No. 10,188,800

DRIVE ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. A drive assembly for a drug delivery device, comprising:a guide nut, the guide nut being rotatable around an axis of the assembly,
a locking means, the locking means being radially movable with respect to the axis in order to engage with the guide nut and to inhibit a rotation of the guide nut,
a body in which the guide nut and the locking means are arranged,
a piston rod,
a cartridge holder that can be attached to and removed from the body, and
a fastener, the fastener being part of or fastened to the cartridge holder and being provided to move the locking means radially with respect to the axis thereby engaging the locking means with the guide nut when the cartridge holder is attached to the body, and to hold the locking means in a position in which the locking means is engaged with the guide nut for drug delivery,
wherein
a screw thread coupling the guide nut and the piston rod enables a helical movement of the piston rod with respect to the guide nut, the helical movement comprising a rotation around the axis and a simultaneous shift along the axis,
the locking means is a resilient element having a first end fastened to the body, the locking means extending in an azimuthal direction from the first end to a second, free end for engaging with the guide nut,
the fastener is a longitudinally protruding part of the cartridge holder, and
the fastener is moved on a circle that is concentric with the guide nut, and is thus made to slide over the locking means and engages the locking means with a structured outer surface of the guide nut by a rotation of the cartridge holder with respect to the body.

US Pat. No. 10,188,798

MEDICAMENT DELIVERY DEVICE

SHL GROUP AB, Nacka Stra...

1. A medicament delivery device comprising:a housing comprising a surface configured for contacting a patient's skin;
a medicament container disposed within the housing, the medicament container comprising a medicament contained behind a movable wall;
an injection needle positioned within the housing and in fluid communication with the medicament container;
a power source configured to store accumulated energy;
a plunger that moves relative to and within the medicament container immediately upon release of the accumulated energy, where the power source acts directly on the plunger such that the plunger directly contacts and moves the movable wall of the medicament container to expel medicament from the medicament container; and
an indication mechanism that is acted upon and directly moved by the plunger when the plunger moves relative to the housing and where the indication mechanism is movable only during delivery of the medicament, where the indication mechanism is not an integral part of the plunger, but is a separate component independent of the plunger and that is positioned within the housing and directly operatively associated with the plunger such that movement of the plunger directly causes separate movement of the indication mechanism only during delivery of the medicament, where a portion of the indication mechanism is visible from outside the device housing indicating that delivery of the medicament is substantially complete.

US Pat. No. 10,188,796

METHOD AND SYSTEM FOR MANAGEMENT OF DIABETES WITH A GLUCOSE MONITOR AND INFUSION PUMP TO PROVIDE FEEDBACK ON BOLUS DOSING

LifeScan IP Holdings, LLC...

1. A method for operating a diabetes management system having an infusion pump, at least one glucose monitor and a microcontroller, the method comprising the following steps performed with the microcontroller:determining a glucose measurement in which a fluid sample with glucose is transformed into enzymatic byproducts by application of electrical signals to the sample;
calculating a bolus recommendation based on the glucose measurement made by the determining step;
evaluating whether the bolus recommendation was followed by a user of the system;
in the event the bolus recommendation was not followed by the user then:
storing the actual bolus delivered by the infusion pump;
measuring the glucose value in subsequent fluid samples and if the glucose values over time is greater than a predetermined high trend threshold then annunciating a high glucose trend, along with the recommended bolus and the actual bolus delivered by the pump otherwise if the glucose values over time is less than a predetermined low trend threshold then annunciating a low glucose trend along with both the recommended bolus and the actual bolus delivered by the pump.

US Pat. No. 10,188,791

SYSTEM AND METHOD FOR ASSURING PATIENT MEDICATION AND FLUID DELIVERY AT THE CLINICAL POINT OF USE

Becton, Dickinson and Com...

1. A system comprising:a wearable electronic device configured to be worn by a user comprising:
a housing,
at least one imaging sensor associated with the housing,
a data transmission interface for sending data to or receiving data from an external electronic device,
a data reporting accessory for providing data to the user,
a microprocessor for managing the at least one imaging sensor, the data transmission interface, and the data reporting accessory, and
a program for acquiring and processing images from the at least one imaging sensor;
a fluid delivery apparatus for passively or actively delivering a therapeutic agent to a patient; and
one or more identification tags attached to or integrally formed with the fluid delivery apparatus,
wherein the program processes an image captured by the at least one imaging sensor to identify the one or more identification tags and acquires fluid delivery apparatus information from the one or more identification tags, and
wherein the program processes a series of images captured by the at least one imaging sensor to determine insertion of a portion of the fluid delivery apparatus in the patient and an indwell time of the portion of the fluid delivery apparatus within the patient, and
wherein the system alerts the user in response to the indwell time of the portion of the fluid delivery apparatus within the patient satisfying a time limit.

US Pat. No. 10,188,790

INDWELLING ASSEMBLY

TERUMO KABUSHIKI KAISHA, ...

1. A method comprising:positioning an assembled indwelling assembly adjacent a patient, the assembled indwelling assembly comprising: an inner needle possessing a sharp needlepoint at a distal end; an inner needle hub fixed to a proximal portion of the inner needle; a hollow outer member in which the inner needle is positioned; an outer member hub fixed to a proximal portion of the hollow outer member; and an elongated member connected to the outer member hub by a hinge structure allowing the elongated member to rotate relative to the outer member hub about a hinge axis, the elongated member extending in a distal direction from the hinge structure;
puncturing a blood vessel of the patient with the sharp needlepoint of the inner needle while the elongated member extends in the distal direction from the hinge structure;
advancing the hollow outer member in the distal direction along the inner needle such that a distal portion of the hollow outer member is inserted to a target position in the blood vessel, the advancing of the hollow outer member in the distal direction along the inner needle being performed while the elongated member extends in the distal direction from the hinge structure, the advancing of the hollow outer member in the distal direction including advancing the hollow outer member in the distal direction together with the outer member hub and the elongated member,
moving the inner needle hub in a proximal direction while simultaneously maintaining the distal portion of the hollow outer member indwelled in the blood vessel such that the inner needle is pulled out from and entirely removed from the hollow outer member; and
rotating the elongated member about the hinge axis after the inner needle is entirely removed from the hollow outer member so that the elongated member rotates relative to the outer member hub, the rotating of the elongated member about the hinge axis including rotating the elongated member away from the distal end of the hollow member.

US Pat. No. 10,188,789

FLUID INFUSION DEVICE WITH SAFETY COUPLING

Medtronic MiniMed, Inc., ...

1. A fluid infusion device, comprising:a drive system that includes a movable slide, the slide including a proximal end opposite a distal end, the proximal end including a projection having a first coupling device; and
a fluid reservoir removably received within a housing of the fluid infusion device that includes a barrel and a stopper disposed within the barrel, the stopper movable relative to the barrel by the slide to advance a fluid out of the fluid reservoir, the stopper including a distal stopper end opposite a proximal stopper end, with a counterbore defined through the distal stopper end, the stopper having a second coupling device coupled to the proximal stopper end, the slide receivable within the barrel such that the proximal end of the slide is adjacent to the distal stopper end and the projection is received within the counterbore, and the second coupling device cooperates with the first coupling device to resist the movement of the stopper relative to the slide.

US Pat. No. 10,188,784

APPARATUS WITH RIGID MEMBER FOR SENSING FLUID PRESSURE

FENWAL, INC., Lake Zuric...

1. A blood processing system, comprising:a first housing configured to be reused for multiple blood processing operations for different donors;
a second housing configured for a single blood processing operation, the second housing insertable to and removable from the first housing, the second housing comprising a conduit configured to house blood and a pressure sensing portion having a rigid member disposed thereon, the rigid member configured to move in response to a change in pressure of the blood; and
a sensor system coupled to the first housing and configured to be reused for multiple blood processing operations, the sensor system comprising a second member and a sensor, the second member removeably coupled to the rigid member, the sensor configured to detect across an air gap movement of the second member and to generate a signal indicative of the movement.

US Pat. No. 10,188,775

LID FOR A MEDICAL WASTE FLUID COLLECTION AND DISPOSAL SYSTEM

Dornoch Medical Systems, ...

1. A lid for a medical waste collection canister, the lid comprising:a head portion comprising:
three cylindrical suction ports extending along a first, second, and third longitudinal axis, respectively, each suction port having a first diameter and each suction port adapted to be connected to suction tubing and further adapted to receive medical waste through a top of the suction port and pass the medical waste through a bottom of the suction port;
a cylindrical auxiliary vacuum port extending along a fourth longitudinal axis and having a second diameter; and
a plurality of tabs spaced apart along a circumferential edge of the head portion; and
a cylindrical portion coupled to the head portion and extending away from a bottom of the head portion along a fifth longitudinal axis,
wherein each of the suction ports and the vacuum port have a cap that is tethered to the lid, each cap sized to correspond to a size of the suction ports or vacuum port.

US Pat. No. 10,188,762

STERILIZING METHOD AND APPARATUS

Turbett Surgical LLC, Ro...

9. A method of sterilizing, the method comprising:(a) occluding a vent port located on one of a sidewall and a door of a sterilizing cabinet with a filter, the sterilizing cabinet having an internal, port-free, bottom surface;
(b) performing a sterilization cycle on the sterilizing cabinet; and
(c) inducing condensate formed during the sterilization cycle to flow along the port-free, bottom surface of the sterilizing cabinet towards the filter of the vent port located on one of a sidewall and a door of the sterilizing cabinet.

US Pat. No. 10,188,709

COMPOSITIONS AND METHODS FOR THE TREATMENT OF PHENYLKETONURIA (PKU)

University of the Science...

1. A pharmaceutical composition comprising a microcapsule, which is enveloped by a membrane comprising ethyl cellulose, and wherein the microcapsule comprises in its interior phenylalanine ammonia lyase and fatty acid-free albumin, wherein the microcapsule has a diameter ranging from about 1 ?m to about 10 ?m.

US Pat. No. 10,188,682

MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE

MEDIZINISCHE HOCHSCHULE H...

1. A method of treatment of liver failure and/or for the protection of hepatocytes against apoptosis and/or for the regeneration of hepatocytes, the method comprising a step of administering to a patient in need of treatment a compound, which is an inhibitor of the activity of MKK4, MKK4 being encoded by the mRNA of SEQ ID NO: 1204, wherein the compound is selected from the group consisting of the following compounds:

US Pat. No. 10,188,674

PARENTERAL FORMULATIONS FOR ADMINISTERING MACROLIDE ANTIBIOTICS

CEMPRA PHARMACEUTICALS, I...

1. A pharmaceutical composition adapted for intravenous administration, the composition comprising one or more antibiotic compounds and a formulating agent, wherein the formulating agent comprises an amino acid selected from the group consisting of arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, histidine, lysine, ornithine, serine, threonine, tryptophan, and tyrosine, and pharmaceutically acceptable salts thereof, and combinations thereof; and where at least one of the one or more antibiotic compounds is of the formula
or a pharmaceutically acceptable salt thereof, wherein:
R10 is hydrogen, acyl or a prodrug moiety;
W is H, F, Cl, Br, I, or OH;
A is CH2, C(O), C(O)O, C(O)NH, S(O)2, S(O)2NH, or C(O)NHS(O)2;
B is C2-C10 alkenylene or C1-C10 alkylene; and
C is hydrogen, hydroxy, acyl, acyloxy, sulfonyl, ureido, or carbamoyl, or alkyl, alkoxy, heteroalkyl, heteroalkoxy, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted.

US Pat. No. 10,188,671

BORON-DIPYRRIN COMPLEX AND MEDICAMENT CONTAINING THE SAME

JAPAN SCIENCE AND TECHNOL...

1. A boron-dipyrrin complex represented by formula (1)
wherein:
X1 represents a halogenoalkyl group;
X2 represents a halogen atom;
R1 represents a hydrogen atom, an alkyl group, or a group represented by formula (b):

R2 and R6 are the same or different and each represent a hydrogen atom or a halogen atom;
R3, R4, R5, and R7 are the same or different and each represent a hydrogen atom, a halogen atom, or an alkyl group;
R8 represents a hydrogen atom or —(CH2)l—(Y)m—(CH2)n—Z wherein Y represents —CO—, —CONH—, or a triazole ring, Z represents a carboxyl group, a sulfonic acid group, or a —CO— peptide residue, l and n each represent an integer of 1 to 6, and m represents 0 or 1;
R9 and R10 are the same or different and each represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; and
R8 and R10 together optionally form an alkylene group.

US Pat. No. 10,188,659

IGF-1R SIGNALING PATHWAY INHIBITORS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

YISSUM RESEARCH DEVELOPME...

1. A method of inhibiting toxic protein aggregation in a subject having a neurodegenerative disease selected from the group consisting of Amyloidosis, Prion disorders, Motor Neuron disease, Alzheimer's disease, Fronto temporal dementia 17 (FTD17), Huntington disease and Parkinson's disease, the method comprising the step of administering to the subject a therapeutically effective amount of a compound represented by the structure of formula I:
wherein
A is H or CN;
Z is S, SO or SO2;
X1, X2, X3, X4, X5, Y1 and Y2 are each independently selected from H, halogen, alkyl, haloalkyl and OR1; and
Y3 and Y4 are each OR1, wherein each R1 is independently H, C1-C4 alkyl, acyl, —(CH2CH2O)nH wherein n is an integer of 1 to 20, or a functional group that gives rise to hydroxyl upon hydrolysis,or salts, hydrates, and solvates thereof.

US Pat. No. 10,188,644

PROCESS OF MAKING STABLE ABUSE-DETERRENT ORAL FORMULATIONS

COLLEGIUM PHARMACEUTICAL,...

1. A pharmaceutical composition comprising solid microparticles or formulated microparticles prepared by:a. preparing a mixture comprising:
(i) oxycodone, myristic acid, beeswax and carnauba wax, or
(ii) oxycodone in the form of a fatty acid salt, beeswax and carnauba wax at a temperature sufficient to form a substantially homogeneous melt;
b. forming solid microparticles from the substantially homogeneous melt;
c. optionally further formulating the solid microparticles with additional pharmaceutically acceptable excipients to provide formulated microparticles, and
d. curing the solid microparticles or the formulated microparticles at a temperature within the range of 25° C. up to and including the inversion temperature, for a minimum of about 48 hours to provide cured solid microparticles or cured formulated microparticles;
wherein the solid microparticles or the formulated microparticles are cured at a first temperature above the inversion temperature and subsequently a second temperature below the inversion temperature.

US Pat. No. 10,188,639

METHODS OF TREATING NEUROLOGICAL, METABOLIC, AND OTHER DISORDERS USING ENANTIOPURE DEUTERIUM-ENRICHED PIOGLITAZONE

DeuteRx, LLC, Andover, M...

1. A method of treating a neurological disorder selected from the group consisting of Parkinson's disease, amyotrophic lateral sclerosis, Friedreich's ataxia, autism spectrum disorder, depression, mild cognitive impairment, Down syndrome, neurodegeneration, adrenoleukodystrophy, Huntington's disease, substance abuse, neuronal injury, and major depression or bipolar disorder cormorbid with metabolic syndrome, comprising administering to a patient in need thereof a therapeutically effective amount of a deuterium-enriched compound of Formula I having an optical purity of at least 75% enantiomeric excess to treat the neurological disorder, wherein Formula I is represented by:
or a pharmaceutically acceptable salt thereof, wherein:
A1, A2, A3, and A4 are independently —C(R9)(R10)—;
A5 is —C(R11)(R12)(R13);
R1, R2, R3, R4, R5, R6, R7, and R8 are independently H or D;
R9, R10, R11, R12, and R13 each represent independently for each occurrence H or D; and
Z is H or D, provided that the abundance of deuterium in Z is at least 30.

US Pat. No. 10,188,638

COMPOUNDS AND COMPOSITIONS FOR INDUCING CHONDROGENESIS

Novartis AG, Basel (CH)

1. A method of treating osteoarthritis or rheumatoid arthritis in a mammal in need thereof, comprising administering to a joint of the mammal a therapeutically effective amount of a compound of Formula IA:or a pharmaceutically acceptable salt, or stereoisomer thereof; wherein“ ”represents a single or double bond;
R0 is selected from hydrogen and C1-6alkyl;
R1 is selected from cyano, 6-membered heterocycloalkyl, 6-membered heterocyclyl, phenyl, and 5- to 9-membered heteroaryl, wherein
the heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R1 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C1-6alkyl, C1-6haloalkyl, —C(O)R13, —C(O)O R13, —NR14aR14b5- and 6-membered heterocycloalkyl, phenyl, and 5- and 6-membered heteroaryl; wherein
R13 is selected from C1-6alkyl, amino, and C1-6alkylamino;
R14a and R14b are each independently selected from hydrogen, C1-6alkyl, —C(O)R15, —C(O)OR15, and —S(O)2R15, wherein R15 is hydrogen or C1-6alkyl; and
the heterocycloalkyl, phenyl or heteroaryl substituent of R1 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, hydroxy, C1-6alkyl, and C1-6haloalkyl,
R3 is selected from C1-6alkyl, C1-6haloalkyl, 5- and 6-membered cycloalkyl, 5- and 6-membered heterocycloalkyl, 6- and 10-membered heterocyclyl, phenyl, and 5- and 6- membered heteroaryl, wherein
the cycloalkyl, heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R3 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C1-6alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6haloalkoxy, —C(O)R16, —C(O)OR16, - S (O)2R16, 5- and 6-membered heterocycloalkyl, and phenyl; wherein
R16 is hydrogen or C1-6alkyl;
the phenyl or heterocycloalkyl substituent of R3 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, and cyano; and
R2 and R4 are each hydrogen or C1-6alkyl; or R2 and R4 taken together form a cyclopropyl ring fused to the bicyclic ring; or R2 and R4 taken together form a bond producing a double bond between the two carbons to which R2 and R4 are attached;
each R5 and R10 is independently hydrogen or C1-6alkyl; or R5 and R10 taken with the atoms to which they are linked form a 5- or 6-membered ring fused to the bicyclic ring; and
R6 and R7 are each hydrogen or C1-6alkyl; or R6 and R7 taken together form a bond producing a double bond between the two carbons to which R6 and R7 are attached;
thereby treating osteoarthritis or rheumatoid arthritis in the mammal.

US Pat. No. 10,188,625

COMBINATION OF A RETINOID AND A DIOL AND POLYUNSATURATED FATTY ACID ESTER

PIERRE FABRE DERMO-COSMET...

1. A combination comprising a retinoid and a compound of the following general formula (I):wherein:n is an integer between 0 and 15,
m is 0, 1, 2 or 3, and
R is the hydrocarbon chain of a polyunsaturated fatty acid selected from omega-3s and omega-6s.

US Pat. No. 10,188,622

USE OF A COMPOSITION COMPRISING FISH OIL AND JUICE FOR THE TREATMENT AND/OR POST TREATMENT OF CANCER

Smartfish AS, Oslo (NO)

1. A method for treatment and/or post treatment of cancer in a subject in need of treatment thereof, the method comprising administering to the subject a therapeutically effective amount of a composition comprising:a combination of fish oil, and
juice in an oil-in water emulsion,
wherein the fish oil has a totox value below 20 and an omega-3 content above 10% by weight based on the total weight of the fish oil and wherein a suitable emulsifier is used to stabilize the emulsion,
wherein the cancer is selected from the group consisting of prostate cancer, lung cancer, and skin cancer and the post treatment of cancer comprises treatment of cachexia, vitamin D deficiency, fatigue, or stimulation of the immune system, and
wherein said suitable emulsifier is selected from the following group consisting of milk solids, whey protein, oat protein, and pea protein.

US Pat. No. 10,188,608

OXIDIZED CELLULOSE MICROSPHERES

Covidien LP, Mansfield, ...

1. A process for forming microspheres comprising:forming a first plurality of microspheres including at least one bioactive agent and oxidized cellulose;
contacting the first plurality of microspheres with a solution of an aliphatic polyester to form a discontinuous phase liquid;
contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and
extracting a second plurality of microspheres from the emulsion, the second plurality of microspheres including one or more microspheres of the first plurality of microspheres at least partially encapsulated in the aliphatic polyester.

US Pat. No. 10,188,590

SKIN-PROTECTION COMPOSITION CONTAINING DENDROBIUM-BASED INGREDIENTS

Hong Kong Baptist Univers...

6. A method for skin protection against UV exposure, skin damage and aging comprising providing a compound having a formula (5) to a subject in need thereof:whereinR2, R4, and R8 are each independently selected from —OR11, —OCH2R11, —OC(O)R11, —OCH2C(O)OR11 and —OC(O)CH2R11;
R1, R5, R6and R10 are each independently selected from hydrogen;
R3,R7 and R9 are each independently selected from hydrogen, halogen, trifluoromethyl, —OR11 and —OC(O)R11; or R2 and R3, or R7 and R8 may be taken together with the carbon atoms to which they are attached to form a cyclic group;
R11 is independently hydrogen or selected from hydrocarbyl and heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R12;
R12 is independently selected from halogen, trifluoromethyl, cyano, nitro, oxo, —OR13, —C(O)R14, —C(O)N(R13)R14, —C(O)OR13, —OC(O)R14, —S(O)2R13, —S(O)2N(R13)R14, —N(R13)R14;
R13 and R14 are each independently hydrogen or selected from hydrocarbyl and heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, cyano, amino, hydroxy, C1-6 alkyl and C1-6 alkoxy;
or a pharmaceutically acceptable salt, prodrug or chemical variant thereof.

US Pat. No. 10,188,583

PORT CONFIGURATIONS FOR A FLUIDS CONTAINER

BAXTER INTERNATIONAL INC....

1. A container closure for use in dispensing fluids from a container, comprising:a base constructed and arranged for being attached to a mouth of the container;
a first port disposed on said base and in fluid communication with the mouth;
a second port disposed on said base in fluid communication with the mouth; and
said first and second ports being visually differentiated from each other,
wherein axes of both generally-cylindrical ports relative to said base are not parallel and do not intersect and lie in uncommon planes, and the orientation of said second port relative to the first port is described by two independent angles.

US Pat. No. 10,188,580

SYSTEMS AND METHODS FOR PROVIDING ENVIRONMENT INFORMATION USING AN UNMANNED VEHICLE

1. A system for providing, to a user, navigation directions to a destination at a destination location, the system comprising:a device worn around a neck of the user and configured to receive an identification of the destination from the user, search for the destination location, and communicate, to an unmanned vehicle, the identification of the destination when the device is unable to determine the destination location; and
the unmanned vehicle for determining the destination location when the device is unable to determine the destination location, the unmanned vehicle having a camera configured to detect image data, and being configured to:
determine an information collecting location,
automatically move to the information collecting location,
detect the image data at the information collecting location,
determine whether the destination is detected from the image data at the information collecting location,
determine the destination location when the destination is detected from the image data at the information collecting location, and
communicate, to the device, the destination location,
wherein the device is further configured to determine and output the navigation directions to guide the user from a current location of the user to the destination location.

US Pat. No. 10,188,561

NONWOVEN FABRIC LAMINATE, ABSORBENT ARTICLE HAVING NONWOVEN FABRIC LAMINATE, AND PROCESS FOR PRODUCING NONWOVEN FABRIC LAMINATE

LIVEDO CORPORATION, Ehim...

1. An absorbent article comprising an exterior sheet formed of a plurality of nonwoven fabric layers, whereinthe exterior sheet is located on an outer side of the absorbent article and has a first nonwoven fabric layer, a second nonwoven fabric layer and a third nonwoven fabric layer from the outer side of the absorbent article,
the first nonwoven fabric layer, the second nonwoven fabric layer and the third nonwoven fabric layer are joined to each other at a first joining part by heat-embossing,
the second nonwoven fabric layer and the third nonwoven fabric layer are further joined to each other at a second joining part by heat-embossing, and
the first joining part and the second joining part have a different shape from each other.

US Pat. No. 10,188,553

DEVICES AND METHODS FOR RESHAPING CARTILAGE STRUCTURES

Chondrocyte, LLC, Hender...

1. A method of shaping a subject's ear to a desired final shape and/or position, the method comprising:lasing the subject's ear so as to stimulate chondrogenesis in the ear;
fitting to the subject's lased ear an integral device comprising:
a first surface configured to fit against and be adhered to the subject's head behind the lased ear, and
a second surface configured to retain the lased ear in a desired final shape and/or position;
wherein, upon fitting of the integral device onto the subject's head and lased ear, the lased ear is maintained in the desired shape and/or position with respect to the subject's head; and
maintaining the integral device on the lased ear until the ear is reshaped to the desired final shape and/or position.

US Pat. No. 10,188,551

SYSTEMS AND METHODS FOR DELIVERING AN OCULAR IMPLANT TO THE SUPRACHOROIDAL SPACE WITHIN AN EYE

GLAUKOS CORPORATION, San...

1. An ocular implant delivery system, comprising:a generally elongated outer housing;
an elongated insertion needle partially disposed in and extending outwardly from the outer housing, the insertion needle having a lumen;
a pusher tube assembly comprising an implant pusher tube and a pusher tube collar fixedly attached to a proximal portion of the implant pusher tube, a distal portion of the implant pusher tube extending through the lumen of the insertion needle;
a trocar assembly comprising a trocar and a trocar collar fixedly attached to a proximal portion of the trocar, a distal portion of the trocar passing through a lumen of the implant pusher tube;
an implant supported on the distal portion of the trocar, wherein a distal tip of the trocar extends distally beyond a distal-most end of the implant when the implant is supported on the distal portion of the trocar; and
a trocar trigger mechanically coupled to the trocar assembly such that a first actuation of the trocar trigger causes the trocar assembly to move the pusher tube assembly distally relative to the insertion needle to a distal locked position, wherein the implant is exposed from the insertion needle for implantation in a suprachoroidal space of an eye when the pusher tube assembly is at the distal locked position, the trocar trigger being further configured such that a second actuation of the trocar trigger causes the distal tip of the trocar to move proximal to the distal-most end of the implant, thereby releasing the implant from being supported on the distal portion of the trocar.

US Pat. No. 10,188,550

APPARATUS AND METHODS FOR DRUG DELIVERY USING MULTIPLE RESERVOIRS

CLEARSIDE BIOMEDICAL, INC...

1. An apparatus, comprising:a housing;
a cartridge assembly, at least a portion of the cartridge assembly configured to be movably disposed in the housing, the cartridge assembly including a first movable member and a second movable member, the second movable member including a seal member configured to form a fluidic seal with an inner surface of the first movable member, the first movable member defining an inner volume bounded by the seal member and the inner surface of the first movable member, at least a portion of the second movable member being movably disposed in the inner volume between a first position and a second position relative to the first movable member;
a first reservoir disposed within the inner volume such that the first reservoir is disposed in a distal position relative to the second movable member, the first reservoir containing a drug when the second movable member is in its first position relative to the first movable member, the first reservoir not being in fluid communication with the inner volume when the second movable member is in its first position, the first reservoir being placed in fluid communication with the inner volume when the second movable member is in its second position relative to the first movable member, the first movable member including a valve member configured to be transitioned from a closed configuration when the second movable member is in its first position relative to the first movable member to an open configuration (1) when the second movable member is moved toward its second position relative to the first movable member, and (2) in response to an increase in pressure within the first reservoir by distal movement of the second movable member from its first position towards its second position, the valve member further configured to be transitioned from the open configuration to the closed configuration after the second movable member is moved towards its second position relative to the first movable member; and
a second reservoir at least partially defined by the housing, a portion of the first movable member being movably disposed in the second reservoir, the second reservoir being fluidically isolated from the inner volume when the second movable member is in its first position relative to the first movable member and the valve member is in its closed configuration, the second reservoir being placed in fluid communication with the inner volume when the second movable member is moved toward its second position relative to the first movable member to receive a volume of the drug from the first reservoir and the valve member is in its open configuration, the first movable member and the second movable member collectively configured to be moved distally from a first position relative to the housing to a second position relative to the housing to expel the volume of the drug from the second reservoir.

US Pat. No. 10,188,549

EXOTHERMIC THERAPEUTIC NATURAL MASSAGE SHELLS

FOREVER YOUNG INTERNATION...

1. An exothermic natural massage shell, comprising:a natural bivalve shell comprising a first half and a second half adhered together with an adhesive to form a hollow chamber;
an aperture formed in the first half to provide a portal to the hollow chamber of the bivalve shell;
an exothermic reactant disposed inside the hollow chamber of the bivalve shell, the reactant being removably inserted through the portal;
wherein the reactant is combined with an activator inside the hollow chamber of the bivalve shell which causes an exothermic reaction that heats the bivalve shell and maintains the bivalve shell at a substantially constant elevated temperature for a duration of time, the hollow chamber and the portal being reusable for repeated exothermic reactions wherein addition of water to the reactant inside the hollow chamber creates an exothermic gel that transfers heat to one or more walls of the halves of the natural bivalve shell; and
wherein the adhesive adhering the first half of the bivalve shell to the second half of the bivalve shell comprises a first elastomeric polymer bonding agent with coefficient of expansion properties operable to maintain first and second halves securely adhered through repeated heating and cooling cycles and a second flexible resin sealant that makes the adhesive moisture-proof.

US Pat. No. 10,188,546

INTRAUTERINE DEVICE WITH CONTROLLED COPPER ION ELUTION

SEBELA VLC LIMITED, Hami...

1. An intrauterine contraceptive device with a controlled ion release rate, the contraceptive device comprising:only one elongate shape memory member sized to fit completely within a human uterus and comprising a first metal having a first galvanic potential, wherein the elongate shape memory member further comprises;
a bottom loop disposed at a bottom of the contraceptive device;
multiple twists located above the bottom loop, forming a spring portion;
a middle portion comprising two parts of the elongate shape memory member extending upward from the multiple twists to form an oval shape;
two bends in the elongate shape memory member at a location above the oval shape of the middle portion, wherein the bends cause the elongate member to cross over itself;
two arms extending from the two bends in opposite directions, wherein one of the arms extends from one of the two bends and the other arm extends from the other of the two bends;
a first end loop forming a first tissue contact surface at an end of one of the two arms; and
a second end loop forming a second tissue contact surface at an end of the other of the two arms, wherein the intrauterine contraceptive device is configured such that, when it is delivered into the human uterus, only the first and second tissue contact surfaces contact the human uterus; and
multiple substance delivery sleeves coupled with the elongate shape memory member and comprising a second metal having a second galvanic potential different from the first galvanic potential, wherein the multiple substance delivery sleeves are coupled with the elongate shape memory member at locations to locally deliver a substance to the uterus in an area near a fallopian tube and an area near a cervical os, the multiple substance delivery sleeves comprising:
at least a first sleeve disposed around the elongate shape memory member on one of the two arms near the first end loop;
at least a second sleeve disposed around the elongate shape memory member on the other of the two arms near the second end loop; and
at least a third sleeve disposed around the elongate shape memory member and threaded within the bottom loop,
wherein the first metal and the second metal are configured to control a galvanic potential difference between the elongate shape memory member and the multiple substance delivery sleeves and thereby provide the controlled ion release rate.

US Pat. No. 10,188,538

HYBRID TRIGGER WIRE FOR ENDOGRAFTS

Cook Medical Technologies...

1. An endovascular prosthesis delivery system comprising:an inner cannula;
a prosthesis comprising graft material releasably secured to the inner cannula, the prosthesis having a radially-inwardly contracted delivery configuration and a radially-expanded deployed configuration, wherein the prosthesis comprises at least two suture loops secured to an outer surface of the prosthesis and circumferentially spaced from each other;
a releasable trigger wire extending along at least a portion of a length of the prosthesis, wherein the releasable trigger wire extends through the graft material and into a graft lumen, wraps around a circumference of the inner cannula, extends back through the graft material to exit the graft lumen and extends through at least one of the at least two suture loops to retain the prosthesis in the radially-inwardly contracted delivery configuration.

US Pat. No. 10,188,537

APPARATUS FOR FOLDING OR UNFOLDING A MEDICAL IMPLANT, AND IMPLANT

Venus Medtech (Hangzhou) ...

1. A foldable and/or unfoldable medical implant comprising:at least three tension threads for folding and/or unfolding the implant; and
at least one first ring having a channel for guiding some or all of the tension threads around the implant at an outside or an circumference thereof, wherein three of the tension threads are wound along or around the outside or circumference of the implant in a manner such that each part of the outside or circumference is covered or contacted by two of the tension treads,
the medical implant further comprises at least a second ring having a channel, and at least three posts, the at least three posts being arranged between the first ring and the second ring in order to connect them with each other and/or to maintain the distance between them, each of the at least three posts having at least two openings through which the tension threads are guided from an inside of the implant to an outside of the implant and back from the outside to the inside, wherein the tension threads are guided to the outside through a first opening of a first one of the posts and back to the inside through a second opening of a second one of the posts, the first opening being different from the second opening, and the first post being different from the second post.

US Pat. No. 10,188,533

MINIMAL SURFACE AREA CONTACT DEVICE FOR HOLDING PLAQUE TO BLOOD VESSEL WALL

Intact Vascular, Inc., W...

1. An intravascular device comprising:a frame consisting of only a single column of cells, the frame comprising:
a pair of concentric side rings comprising a single distal undulating ring and a single proximal undulating ring spaced apart coaxially from each other, each of said pair of concentric side rings having a compressed state and an expanded state and forming one end of the device; and
a plurality of longitudinally extending bridge members connecting the pair of concentric side rings, wherein each bridge member of the plurality of longitudinally extending bridge members connects to one of the pair of concentric side rings at one end and to the other of the pair of concentric side rings at an opposite end of the device; and
each of the bridge members comprising two pointed barbs extending from the bridge members in at least one of a circumferential manner and a tangential manner, wherein each of the two pointed barbs has a V-shape structure, and wherein a pointed end of the V-shape structure is pointed in a direction perpendicular to the longitudinal axis of the device;
wherein each cell of the single column of cells comprises a portion of each of the pair of concentric side rings and two of the plurality of longitudinally extending bridge members.

US Pat. No. 10,188,523

PROSTHETIC ANKLE COMPONENTS

Biomet UK Healthcare Limi...

1. A first prosthetic ankle component comprising:a first bearing surface configured to slidably engage a second bearing surface of a second prosthetic ankle component when in an installed configuration; and
one or more protrusions protruding from the first bearing surface, the protrusions being configured to be received by one or more corresponding receiving portions provided on the second prosthetic ankle component,
wherein the one or more protrusions are further configured such that the interaction with the receiving portions permits the first and second prosthetic ankle components to slide with respect to one another in an interface plane defined by the interface between the first and second bearing surfaces, and wherein the protrusions are further configured to restrict the first and second prosthetic ankle components moving away from one another in a direction with a component perpendicular to the interface plane, and wherein the protrusion includes an abutment surface configured to abut a closed end of the of the second prosthetic ankle component to limit a sliding movement in a first direction; and
wherein the first prosthetic ankle component further comprises a lip, the lip being provided at or towards an edge of the first bearing surface, the lip being configured to limit sliding movement of the first and second prosthetic ankle components in a second direction which is opposite the first direction by having an abutment surface configured to abut a surface of the second prosthetic component, wherein the abutment surface of the protrusion and the abutment surface of the lip are opposed to and facing each other so as to limit sliding movement in both the first direction and the second direction which is opposite the first direction.

US Pat. No. 10,188,522

SYSTEM FOR REPLACEMENT OF AT LEAST A PORTION OF A CARPAL ARTICULAR SURFACE OF A RADIUS

TOBY ORTHOPAEDICS, INC., ...

1. A system for replacement of at least a portion of a carpal articular surface of a radius, the system comprising:a prosthesis having a plate-like portion and at least one portion, said plate-like portion having an exterior surface formed thereon, and said at least one portion being positioned opposite from said exterior surface and being adapted to directly contact an interior portion of the radius, said at least one portion having at least one aperture provided therein, said exterior surface being sized and shaped to approximate the surface of the at least a portion of the carpal articular surface of the radius, and said at least one aperture of said at least one a portion of said prosthesis being adapted to receive at least one fastener therein;
a bone plate having a first end an opposite second end, and a length and a longitudinal axis extending between said first end and said second end, said bone plate having a width perpendicular to the length of said bone plate, said bone plate having an upper surface, a lower surface, and a thickness extending between said upper surface and said lower surface, said lower surface being adapted to contact an exterior of the radius, said bone plate having at least one opening passing from said upper surface through said lower surface and being configured to receive said at least one fastener therethrough, at least a portion of said bone plate being configured to be attached to the radius proximate of the distal end thereof, said bone plate and said at least one portion of said prosthesis being spaced from one another when said system is assembled and being adapted to clamp a portion of the radius between said lower surface of said bone plate and said at least one portion of said prosthesis via said at least one fastener drawing said bone plate and said at least one portion of said prosthesis toward one another; and
said at least one fastener having a first end for insertion through said at least one opening and into said at least one aperture, said at least one fastener being configured to secure attachment of said prosthesis and said bone plate to one another across a portion of the radius.

US Pat. No. 10,188,516

STENT LOADING TOOL AND METHOD FOR USE THEREOF

Medtronic Ventor Technolo...

1. A loading system for loading a valve prosthesis into a delivery catheter, the loading system comprising:a loading tool comprising a loading tool connection member, wherein the loading tool connection member comprises a first plurality of prongs, wherein the loading tool connection member includes an open state with the first plurality of prongs flared outwardly and a closed state with the first plurality of prongs radially contracted;
a valve prosthesis including a radially compressed configuration and a radially expanded configuration, the valve prosthesis comprising valve prosthesis connection members configured to removably engage with a respective one of the first plurality of prongs, wherein the loading tool is configured to engage the valve prosthesis with the valve prosthesis in the radially expanded configuration and the loading tool in the open state; and
a crimping tool comprising a proximal end and a distal end, wherein the diameter of the distal end is greater than the diameter of the proximal end,
wherein the loading tool connection member, in the open state while engaged with the valve prosthesis in the radially expanded configuration, is configured to pass through the crimping tool such that the valve prosthesis crimps from the radially expanded configuration to the radially compressed configuration and the loading tool connection member radially contracts from the open state to the closed state.

US Pat. No. 10,188,514

TRANSCATHETER VALVE PROSTHESIS

HIGHLIFE SAS, Paris (FR)...

1. A heart valve system, the system comprising:a radially self-expandable tubular body having an inflow end and an outflow end, the tubular body including a plurality of beams at the outflow end of the tubular body; and
a valve coupled to the outflow end of the tubular body such that an entirety of the valve is distal of the inflow end of the tubular body, the valve including a plurality of valve leaflets,
wherein:
each valve leaflet is supported by only two beams of the plurality of beams,
connection points link the inflow end of the tubular body and the plurality of beams, a number of connection points being equivalent to a number of the valve leaflets, and
each beam of the plurality of beams is directly connected to an adjacent beam so that the plurality of beams extends the entire circumferential length of the tubular body at the outflow end.

US Pat. No. 10,188,506

INTRAOCULAR LENS INSERTER

Alcon Pharmaceuticals, Lt...

1. An implant inserter comprising:a compressed gas storage portion comprising a compressed gas cartridge configured to release a compressed gas into the compressed gas storage portion;
a hydraulic portion containing a substantially incompressible fluid;
a piston disposed between the compressed gas cartridge and the hydraulic portion and configured to impart pressure of the released compressed gas in the compressed gas storage portion to the substantially incompressible fluid in the hydraulic portion;
an actuator portion comprising a button or lever and a plunger mounted for sliding movement between a retracted position and an extended position, the actuator portion configured to allow a user to control a flow of the substantially incompressible fluid through the hydraulic portion to move the plunger from the retracted position to the extended position by using the button or lever; and
an implant retaining portion comprising an implant for insertion into a treatment region of an animal and aligned with the plunger such that the plunger pushes the implant when the plunger moves from the retracted position toward the extended position.

US Pat. No. 10,188,505

MATERIALS AND METHODS FOR IMPROVED BONE TENDON BONE TRANSPLANTATION

RTI Surgical, Inc., Alac...

1. A method of conducting orthopedic surgery on a recipient comprising:before the surgery, obtaining a bone/tendon allograft comprising (a) a first human bone block said first human bone block pre-shaped before surgery as a first pre-shaped dowel bone block having a dowel diameter specially adapted for fixation in a bone tunnel having a tunnel diameter for which the dowel is adapted, and (b) a tendon attached to said first human bone block via a naturally occurring attachment;
during the surgery, implanting the first human bone block in said bone tunnel having a diameter for which the first pre-shaped dowel bone block is adapted.

US Pat. No. 10,188,503

PROSTHESIS HAVING PIVOTING FENESTRATION

Cook Medical Technologies...

1. A prosthesis, comprising:a graft having a tubular body and a surface comprising a first biocompatible material;
at least one pivoting fenestration having a diameter extending from a sidewall of the graft;
a first perimeter having a first diameter and surrounding the at least one pivoting fenestration;
a band of flexible material surrounding the first perimeter and having a flexible frame;
a second perimeter in the side wall surrounding the band of flexible material and having a second diameter greater than the first perimeter diameter;
a first non-pivoting fenestration having a diameter disposed in the side wall of the graft; and
a second non-pivoting fenestration having a diameter disposed in the side wall of the graft,
where the band of material has a first diameter substantially the same as the first perimeter diameter and a second diameter substantially the same as the diameter of the second perimeter, and where the diameter of the band of material decreases in a direction away from the surface of the graft from the second perimeter to the first perimeter;
where the at least one pivoting fenestration is pivotable in any direction away from an axis perpendicular to a longitudinal axis of the prosthesis,
where at least one of the first non-pivoting fenestration and the second non-pivoting fenestration has a scallop configuration.

US Pat. No. 10,188,502

AORTIC GRAFT DEVICE

Cook Medical Technologies...

1. A prosthesis comprising:a unitary tube of graft material, the unitary tube of graft material comprising:
a stented graft portion having an outer perimeter, an inner lumen, a first end, a second end,
a completely unstented crimped portion integrally formed with and extending from the first end of the stented graft portion to form a junction between the unstented crimped portion and the first end of stented graft portion, the unstented crimped portion having an outer perimeter, and the junction having a circumference,
a plurality of independent ring stents extending from the junction to the second end of the stented graft portion including a first stent ring and a series of undulating ring stents extending distally from the first ring stent to the distal end of the stented graft portion,
a collar substantially at the junction between the first end of the stented graft portion and the unstented crimped portion and extending about the circumference of the junction,
at least one fenestration in the tube of graft material, and
a branch extending from the at least one fenestration in the tube of graft material,
wherein the first ring stent of the plurality of ring stents is disposed directly adjacent to the collar,
wherein the collar extends radially away from and beyond the entire outer perimeters of both the stented graft portion and the unstented crimped portion, such that the collar is configured to provide an extended stable surface structure away from the outer perimeters of the stented graft portion and the unstented crimped portion for the passage of sutures without the passage of sutures into the lumens of either the stented graft portion or the unstented crimped portion.

US Pat. No. 10,188,501

FORK-TYPE COVERED STENT

Lifetech Scientific (Shen...

1. A bifurcated stent graft, comprising:a body;
a side branch that forms an acute angle with the body, the side branch comprising a covering film and a first bare stent disposed only on the covering film, with a part of the first bare stent positioned adjacent a boundary line of the body and the covering film, and is located in a vertex angle area of the acute angle; and
wherein the first bare stent comprises at least one metal ring that defines different waveforms that include struts and a plurality of proximal vertices and a plurality of distal vertices, each strut having a proximal vertex and a distal vertex at opposite ends thereof, with an axial distance defined for the strut between each connecting proximal vertex and distal vertex, and wherein the axial distances are different along the at least one metal ring, with the strut closest to the acute angle having the shortest axial distance, and the strut furthest from the acute angle having the longest axial distance.

US Pat. No. 10,188,495

POSITIONING AGENT AND METHOD OF USING THE SAME

ATRIUM MEDICAL CORPORATIO...

1. A method of implanting a surgical mesh prosthesis, comprising the steps of:positioning a surgical mesh prosthesis against a surface of a target tissue with a positioning agent disposed between the surgical mesh prosthesis and the surface of the target tissue, wherein the positioning agent has an adhesion strength adequate to maintain the surgical mesh prosthesis temporarily in place, otherwise unsupported, against the target tissue in the absence of setting or curing of the positioning agent; and
adhering the surgical mesh prosthesis against the surface of the target tissue by the adhesion strength of the positioning agent;
wherein the positioning agent has a dynamic viscosity that comprises a first viscosity, when tested at 0.1 S?1 and 23° C., between about 150 Cps and 26,000,000 Cps, and a second viscosity, when tested at 9.77 S?1 and 23° C., that is between about 50 Cps and 2,530,000 Cps; and
wherein the positioning agent is a solution, gel or paste that includes water and one or more components selected from the group consisting of glycerin, sodium carboxymethylcellulose, maltrodextrin, hypromellose, carbopol resin, aloe vera, collagen and xantham gum.

US Pat. No. 10,188,491

DENTAL RESTORATION PRODUCING SYSTEM FOR PRODUCING DENTAL RESTORATION FROM DENTAL MILL BLANK WITH THROUGH-HOLE, OPERATION SYSTEM OF THE SYSTEM, PROGRAM FOR THE SYSTEM, AND DENTAL MILL BLANK FOR USE IN THE SYSTEM

SHOFU INC., Kyoto (JP)

1. A dental restoration producing system of producing a dental restoration from a dental mill blank with one or more through-holes, comprising;a data taking-in section taking in a dental mill blank shape data which indicates a shape of a dental mill blank and includes a position data of one or more through-holes, and a dental restoration shape data which indicates a shape of a dental restoration to be produced,
a superposed data generating section generating a superposed data in which the dental restoration is superposed in the dental mill blank based on the dental mill blank shape data and the dental restoration shape data, and
a control section controlling cutting of the dental mill blank based on the superposed data, wherein,
when the dental restoration includes no through-hole of the dental restoration, the superposed data generating section generates a superposed data in which at least one through-hole among the one or more through-holes of the dental mill blank is not superposed with the dental restoration,
when the dental restoration includes a through-hole of the dental restoration, the superposed data generating section generates a superposed data in which at least one through-hole among the one or more through-holes of the dental mill blank is not superposed with the dental restoration and the through-hole of the dental restoration, or a superposed data in which at least one through-hole among the one or more through-holes of the dental mill blank is included in the through-hole of the dental restoration which is larger than the at least one through-hole among the one or more through-holes of the dental mill blank, and
the control section controls cutting so that cutting is started from the at least one through-hole among the one or more through-holes of the dental mill blank.

US Pat. No. 10,188,490

METHODS AND SYSTEMS FOR DENTAL PROCEDURES

Align Technology, Inc., ...

1. A method for digitally aligning a patient's teeth with a reference portion of the patient, the method comprising:acquiring, using a scanner, a first image of at least a portion of the patient's teeth;
positioning a device in a patient's mouth to align the device with a reference portion of the patient, the device comprising an occlusal portion and a non-occlusal portion, the occlusal portion comprising a bite plate held between the patient's teeth so as to secure the device in a position during a scanning procedure and the non-occlusal portion comprising a coded pattern for aligning scanned images of the patient, the occlusal portion and the non-occlusal portion being coupled together at an angle such that the coded pattern is outwardly oriented from the patient's mouth when the bite plate is positioned between the patient's teeth, so that the coded pattern is presented to permit scanning of the coded pattern simultaneously when scanning at least the portion of the patient's teeth;
acquiring, using the scanner, a second image of at least a portion of the coded pattern and at least the portion of the patient's teeth: and
processing the first image and the second image to determine a spatial relationship between at least the portion of the patient's teeth and the reference portion by calculating a first spatial relationship between at least the portion of the coded pattern and at least the portion of the patient's teeth and the alignment between the device and the reference portion.

US Pat. No. 10,188,481

BEAM GUIDE FOR OPHTHALMIC SURGICAL ILLUMINATION

Novartis AG, Basel (CH)

1. An ophthalmic illumination apparatus, comprising:a movable support;
an optical array coupled to the movable support and positioned to interact with a light beam from a light source, the optical array including first and second optical elements, wherein the first optical element is configured to reflect and transmit first associated amounts of the light beam, and wherein the second optical element is configured to reflect and transmit second associated amounts of the light beam different than the first optical element; and
a drive mechanism coupled to the movable support, wherein the drive mechanism is configured to cause the movable support to selectively move the optical array such that the light beam is selectively incident upon one of the first optical element or the second optical element.

US Pat. No. 10,188,461

SELECTIVE FAT REMOVAL USING PHOTOTHERMAL HEATING

THE REGENTS OF THE UNIVER...

1. A method for selective removal of fat in a subject in need thereof, comprising:distributing photo-absorbing nanoparticles uniformly within a target area comprising adipose tissue located beneath a skin surface of the subject by injecting a solution comprising gold nanorods suspended in a biocompatible liquid at a concentration range of 1011 to 1013 GNR/mL; and
delivering a series of pulses of near infrared light across the skin surface and into the target area for an exposure duration to induce surface plasmon resonance in the nanoparticles, wherein the near infrared light has a combination of optical parameters selected from the group consisting of beam energy, pulse duration, emission wavelength within a range of 700 to 900 nm, emission intensity, beam focus and beam area, the optical parameters and the exposure duration selected to excite the nanoparticles to liquefy fat within the target area.

US Pat. No. 10,188,458

INDUCTIVE DISTURBANCE REDUCTION DEVICE

Koninklijke Philips N.V.,...

1. An inductive disturbance reduction device for reducing an inductive disturbance of signals transmitted via first connection conductors of an electrical connector, the inductive disturbance being caused when radio frequency ablation current usable for ablating tissue flows through a second connection conductor of the electrical connector, wherein the electrical connector is adapted to electrically connect an ablation catheter with a radio frequency ablation current source, the inductive disturbance reduction device comprising:first compensation conductors adapted to be electrically connected to the first connection conductors of the electrical connector, the first compensation conductors of the inductive disturbance reduction device being adapted to transmit the signals, and
a second compensation conductor adapted to be electrically connected to the second connection conductor of the electrical connector, the second compensation conductor of the inductive disturbance reduction device being adapted to transmit the radio frequency ablation current, wherein:
the first compensation conductors and the second compensation conductor of the inductive disturbance reduction device are arranged such that a compensation voltage is induced in the first compensation conductors of the inductive disturbance reduction device when the radio frequency ablation current flows through the second compensation conductor of the inductive disturbance reduction device; and
the compensation voltage induced in the first compensation conductors of the inductive disturbance reduction device at least partly compensates a connection voltage, having a polarity opposite a polarity of the compensation voltage, induced in the first connection conductors of the electrical connector when the radio frequency ablation current flows through the second connection conductor of the electrical connector.

US Pat. No. 10,188,455

ELECTROSURGICAL APPARATUS FOR GENERATING RADIOFREQUENCY ENERGY AND MICROWAVE ENERGY FOR DELIVERY INTO BIOLOGICAL TISSUE

CREO MEDICAL LIMITED, Ch...

1. An electrosurgical apparatus for resection of a biological tissue, the apparatus comprising:a radiofrequency (RF) signal generator for generating RF electromagnet (EM) radiation having a first frequency;
a microwave signal generator for generating microwave EM radiation having a second frequency that is higher than the first frequency;
a probe arranged to deliver the RF EM radiation and the microwave EM radiation separately or simultaneously from a distal end thereof; and
a feed structure for conveying the RF EM radiation and the microwave EM radiation to the probe, the feed structure comprising an RF channel for connecting the probe to the RF signal generator, and a microwave channel for connecting the probe to the microwave signal generator,
wherein the RF channel and microwave channel comprise physically separate signal pathways from the RF signal generator and microwave signal generator respectively,
wherein the feed structure includes a combining circuit having a first input connected to the separate signal pathway on the RF channel, a second input connected to the separate signal pathway on the microwave channel, and an output connected to a common signal pathway for conveying the RF EM radiation and the microwave EM radiation separately or simultaneously along a single channel to the probe,
wherein the microwave channel includes a waveguide isolator connected to isolate the separate signal pathway on the microwave channel from the RF EM radiation,
wherein the waveguide isolator has an adjustable impedance,
wherein the combining circuit is integrated with the waveguide isolator,
wherein the output connected to the common signal pathway includes an output probe mounted on the output section of the waveguide isolator, the output probe having a coupling conductor extending into the waveguide isolator to couple the microwave EM energy therefrom, and
wherein the first input includes an RF connector mounted on the waveguide isolator, the RF connector having a signal conductor that extends into a waveguide cavity of the waveguide isolator to electrically contact the coupling conductor of the output probe.

US Pat. No. 10,188,454

SYSTEM FOR MANUFACTURING ELECTROSURGICAL SEAL PLATES

COVIDIEN LP, Mansfield, ...

1. An end effector configured for use with an electrosurgical forceps device, the end effector comprising:a first jaw member comprising a first sealing surface including a plurality of flanges configured to secure the sealing surface to an overmolding material; and
a second jaw member operably coupled to the first jaw member such that at least one of the first jaw member or the second jaw member is movable relative to the other between an open condition and a closed condition, the second jaw member including:
a second sealing surface having a recess defined therein; and
a spacer extending from the recess and configured to maintain a gap distance between the first and second sealing surfaces when the first and second jaw members are in the closed condition.

US Pat. No. 10,188,450

BLADE DEPLOYMENT MECHANISMS FOR SURGICAL FORCEPS

COVIDIEN LP, Mansfield, ...

1. A forceps, comprising:a first shaft member having a jaw member at a distal end thereof;
a second shaft member having a jaw member at a distal end thereof,
the first and second shaft members pivotally coupled to each other about a pivot to move the jaw members between an open position and a closed position;
a trigger disposed on one of the first or second shaft members;
a blade operatively coupled to the trigger such that actuation of the trigger translates the blade;
an interference member engaged with the trigger when the jaw members are in the open position to prevent actuation of the trigger, one of the first or second shaft members configured to contact the interference member to move the interference member out of engagement with the trigger when the jaw members are moved to the closed position to permit actuation of the trigger;
an actuator disposed within a recess formed in the first shaft member such that the actuator is recessed from an outer surface of the first shaft member, the actuator configured to supply electrosurgical energy to at least one of the jaw members; and
a tab extending from the second shaft member and configured to be received within the recess upon approximation of the first and second shaft members to depress the actuator.

US Pat. No. 10,188,449

SYSTEM AND METHOD FOR TEMPERATURE ENHANCED IRREVERSIBLE ELECTROPORATION

COVIDIEN LP, Mansfield, ...

6. An electrosurgical system, comprising:an electrosurgical generator including:
a power supply configured to output DC power;
an inverter coupled to the power supply, the inverter including a plurality of switching elements; and
a controller coupled to the inverter and configured to signal the inverter to simultaneously generate based on the DC power a radio frequency heating waveform and an electroporation waveform, which is a pulsatile DC waveform configured to generate an electric field and includes a plurality of pulses having an initial pulse with a higher peak voltage and a higher rate of increase of voltage than any subsequent pulse; and
an electrosurgical instrument configured to couple to the inverter and to transmit simultaneously the radio frequency waveform and the electroporation waveform.

US Pat. No. 10,188,448

ELECTROSURGICAL SYSTEM FOR MULTI-FREQUENCY INTERROGATION OF PARASITIC PARAMETERS OF AN ELECTROSURGICAL INSTRUMENT

COVIDIEN LP, Mansfield, ...

1. An electrosurgical system comprising:an electrosurgical generator including:
an output stage, having a non-resonant inverter, configured to generate electrosurgical energy at a plurality of radio frequencies;
a plurality of sensors configured to sense a voltage waveform and a current waveform of the electrosurgical energy; and
a controller coupled to the output stage and the plurality of sensors; and
an instrument coupled to the electrosurgical generator and configured to supply the electrosurgical energy to tissue,
wherein the controller is further configured to calculate at least one parasitic parameter based on the electrosurgical energy at the plurality of radio frequencies and control the output stage to adjust an amplitude of the electrosurgical energy based on the at least one parasitic parameter.

US Pat. No. 10,188,446

RESONANT INVERTER

COVIDIEN LP, Mansfield, ...

1. An electrosurgical generator comprising:a tank configured to output energy, wherein the tank functions as an LCLC tank;
an H-bridge configured to drive the tank;
a transformer including:
a first core half;
a second core half;
a primary winding; and
a secondary winding having a number of turns, wherein each turn is separated by a constant gap; and
a bobbin coupled to the first core half and the second core half,
wherein the secondary winding is disposed on the bobbin,
wherein the constant gap provides a parallel capacitance of the LCLC tank, the parallel capacitance being in parallel with a secondary side of the transformer, and
wherein the secondary winding is the only component of the tank that provides the parallel capacitance such that the parallel capacitance is not provided by any discrete component.

US Pat. No. 10,188,445

NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS

Medtronic Ardian Luxembou...

1. A cryotherapeutic device, comprising:an elongate shaft having a distal end portion, wherein the shaft is configured to locate the distal end portion intravascularly at a treatment site within a renal artery of a human patient; and
a cooling assembly at the distal end portion of the shaft, wherein the cooling assembly is transformable between a low-profile delivery state and an expanded deployed state, and wherein the cooling assembly includes
a cooling balloon having a helical shape when the cooling assembly is in the deployed state, and
an insulating balloon having a helical shape when the cooling assembly is in the deployed state,
wherein the cooling balloon and the insulating balloon are intertwined when the cooling assembly is in the deployed state.

US Pat. No. 10,188,444

SKIN PROTECTION FOR SUBDERMAL CRYOGENIC REMODELING FOR COSMETIC AND OTHER TREATMENTS

MyoScience, Inc., Fremon...

1. An apparatus for cryogenically treating tissue, the apparatus comprising:a housing having a proximal and distal end, the housing including a heat source;
at least one needle probe extending from the distal end of the housing and comprising at least one elongate needle having a distal needle shaft portion and a proximal needle shaft portion, wherein the proximal needle shaft portion is more conductive than the distal needle shaft portion, wherein the proximal needle shaft portion extends axially along a longitudinal axis of the at least one elongate needle, and wherein the at least one elongate needle comprises a first conductive material at the distal needle shaft portion and a second conductive material at the proximal needle shaft portion conductively coupled to the first conductive material, the at least one elongate needle configured to be advanced into non-target tissue layered above target tissue such that the first conductive material at the distal needle shaft portion is positioned within and in contact with the target tissue and the second conductive material at the proximal needle shaft portion is positioned within and in contract with the non-target tissue; and
a cooling supply tube internally housed within the at least one elongate needle, wherein the cooling supply tube includes an exit within the at least one elongate needle.

US Pat. No. 10,188,441

DRUG DELIVERY IMPLANT IMPLANTED INTO BONE

UNIVERSITY-INDUSTRY COOPE...

1. A drug delivery implant configured to be implanted into a bone, comprising:a hollow implant fixture provided with an inlet formed at an upper end thereof; and
a drug supply cartridge coupled to the hollow implant fixture,
wherein the drug supply cartridge includes:
a cap for closing the inlet of the hollow implant fixture; and
a cartridge main body provided under the cap, coupled with the cap so as to be mounted in the hollow implant fixture integrally with the cap, and accommodated in the hollow implant fixture to release a drug,
wherein a cartridge hole to accommodate the cartridge main body and drug channels to guide a drug released from the inside of the cartridge main body to the outside of the hollow implant fixture are formed in the hollow implant fixture,
wherein the cartridge main body includes:
an outer membrane including first release holes to release the drug to the outside of the cartridge main body and forming an outer cover of the cartridge main body; and
an inner membrane including second release holes closed by the outer membrane, stacked in the outer membrane and closing the first release holes, the first release holes and the second release holes being selectively communicable with each other by an external force applied to the cartridge main body.

US Pat. No. 10,188,440

METHOD AND DEVICE FOR DELIVERING MEDICINE TO BONE

Spinal Generations, LLC, ...

1. A method for delivering multiple substances in a delayed fashion to a bone of a patient, comprising:providing a cannulated bone screw, wherein the bone screw comprises first and second fenestrations disposed along a shaft of the bone screw and connecting to a cannulation of the bone screw;
inserting an insert into the bone screw;
creating an aperture in skin of a patient;
inserting the bone screw into the bone of the patient through the aperture;
delivering a first substance into the bone through the bone screw, wherein the first substance changes over time into an at least partially solid hardened material; and
delivering a second substance into the bone through the bone screw and through the first substance after the first substance has changed into the at least partially solid hardened material;
wherein the first and second substances are delivered into the bone through the insert; and
wherein the insert is moveable within the cannulation of the bone screw to deliver the first substance through at least one of the first and second fenestrations and to deliver the second substance through at least one of the first and second fenestrations.

US Pat. No. 10,188,436

INFLATABLE MEDICAL DEVICES

LOMA VISTA MEDICAL, INC....

1. A device for delivering a material to an orthopedic target site comprising:a flexible tube having a first lumen having a first end and a second end;
a pusher having a pusher total length between a pusher first end and a pusher second end, wherein the pusher comprises a pusher first length and a pusher second length, wherein the pusher first length has a first rigidity and the pusher second length has a second rigidity, said pusher comprising a first member spanning the first length and the second length, and a stiffening sheath spanning an entirety of only the first length; and
wherein the first rigidity is greater than the second rigidity; and
wherein the pusher and tube are configured for the pusher to be slidably received by the first end of the first lumen; and
wherein the material is located in the first lumen between the pusher and the second end.

US Pat. No. 10,188,429

VERTEBRAL FIXATION SYSTEM

Zimmer Spine, Inc., Edin...

1. A system for post-operative adjustment of a spinal stabilization system, comprising:a flexible and pliable elongate ligature member having a first portion and a second portion that form a loop;
a housing comprising:
an opening configured to receive the first and second portions of the flexible and pliable elongate ligature member; and
a rod receiving member;
a rod locking mechanism configured to engage and fix a rod within the rod receiving member; and
a post-operative tension adjustment mechanism for adjusting the tension of the first and second portions of the flexible and pliable elongate ligature member in situ via winding the first and second portions.

US Pat. No. 10,188,428

SUBCUTANEOUS IMPLANTABLE DEVICE FOR GRADUALLY ALIGNING A SPINE

1. A subcutaneous implantable device for aligning a spine having a plurality of vertebrae, comprising:a stabilizing plate assembly;
a first rod, including:
a first end; and,
a second end pivotably connected to the stabilizing plate assembly;
a second rod, including:
a third end; and,
a fourth end pivotably connected to the stabilizing plate assembly;
a winding assembly; and,
a tensioning member including a line, the line having:
a first end; and,
a second end secured to the winding assembly;
wherein the line is connected to the stabilizing plate assembly.

US Pat. No. 10,188,426

EMBRYO TRANSFER CATHETER AND METHOD

1. An improved method of transferring an embryo into a uterus via a cervix of a recipient, the method comprising:providing an outer catheter body having first and second lumens, the first lumen having an inflatable balloon provided at a distal end of the first lumen;
up to several minutes, hours, days or weeks or longer before an embryo transfer:
inserting the outer catheter body into the uterus through the cervix;
inflating the balloon with fluid so that the outer catheter body is retained in the uterus;
closing off the second lumen by inserting a removable flexible plastic stent that is closed and lockable in position by a locking mechanism;
at the embryo transfer:
opening the second lumen in the outer catheter body;
inserting a matching internal catheter into the second lumen;
passing an embryo or embryo-containing cannula through the internal catheter to transfer an embryo into the uterus;
following embryo transfer:
reclosing the second lumen; and,
retaining the outer catheter body in the uterus for up to several hours or days or longer after the embryo transfer wherein, in use, the transferred embryo is prevented from expulsion by obstruction of the cervix and physical disturbance of an endometrium can be minimised.

US Pat. No. 10,188,425

PACEMAKER RETRIEVAL SYSTEMS AND METHODS

Pacesetter, Inc., Santa ...

1. A catheter for retrieving a medical device from a patient, comprising:a catheter shaft;
a snare disposed within the catheter shaft and extendable distally beyond the catheter shaft;
a docking cap disposed on a distal portion of the catheter shaft, the docking cap being rotatable independent of the catheter shaft, wherein the docking cap includes an interior configured to receive the medical device;
a torque shaft disposed within the catheter shaft and extending through the docking cap into the interiors; and
a handle coupled to the catheter shaft and the torque shaft, wherein the handle is operably configured to move the torque shaft proximally relative to the catheter shaft to connect the torque shaft to the docking cap, and wherein the handle is operably configured to rotate the torque shaft relative to the catheter shaft to apply rotational torque to the docking cap when the torque shaft is connected to the docking cap.

US Pat. No. 10,188,423

MULTI-PIECE GIMBAL RING

HeartWare, Inc., Miami L...

16. A mounting structure for connecting a device to the heart, the mounting structure comprising:a mounting ring defining a bore, the mounting ring being adapted for mounting to an exterior surface of the heart of a living subject, the mounting ring including a collar having a deformable wall defining a main bore;
a clamp engaged with the collar, the clamp being arranged to deform the collar so as to constrict the main bore;
a gimbal ring disposed within the main bore, the gimbal ring defining a gimbal bore co-axial with the main bore and including a plurality of separate arcuate elements cooperatively disposed in a circumferential direction around the gimbal bore, the plurality of separate arcuate elements being rigid and movable toward one another to constrict the gimbal bore;
a deformable tube, the deformable tube defining a one-way valve and being more readily deformable than the plurality separate of arcuate elements, the deformable tube being configured to connect the plurality of separate arcuate elements with one another;
each of the plurality of separate arcuate elements includes a slot at a first end and a projection at the opposite second end, and at least one of the plurality of arcuate elements is slideably engaged with at least one other of the plurality of arcuate elements to provide movement relative to one another in the circumferential direction; and
the plurality of separate arcuate elements being movable from an unconstricted condition in which a gap is defined between adjacent arcuate element and a constricted condition in which the gaps are closed.

US Pat. No. 10,188,421

METHODS FOR PLACING A SYMPATHETIC BLOCK, CATHETERS, CATHETER ASSEMBLIES AND RELATED METHODS

Custom Medical Applicatio...

1. A catheter assembly for use in administering medication to at least one of a peripheral nervous system of a subject or a spinal cord of a subject, the catheter assembly comprising:a catheter comprising:
a flexible catheter tube having a proximal end and a distal end, the catheter tube for administering medication to the at least one of the peripheral nervous system of the subject the spinal cord of the subject;
at least two tine elements coupled to an outer surface of the flexible catheter tube and positioned proximate the distal end of the flexible catheter tube, the at least two tine elements configured to enable insertion of the catheter through an introducer needle into a subject and to engage with at least a portion of the subject when the catheter is inserted within the subject;
a helical coil spring for radially stiffening the flexible catheter tube, the helical coil spring extending a length of the catheter and having at least two closed portions and at least one open portion, the at least one open portion having an open pitch extending axially along multiple loops of the helical coil spring that is greater than a closed pitch of the at least two closed portions, each closed portion extending axially along multiple loops of the helical coil spring, the at least one open portion positioned directly between a first closed portion having the closed pitch positioned at the distal end of the catheter tube and a second closed portion having the closed pitch of the at least two closed portions, the at least one open portion enabling a fluid to pass through the helical coil spring to an opening formed in a sidewall of the flexible catheter tube, wherein the at least two tine elements are positioned at the at least one open portion of the helical coil spring at a distal portion of the helical coil spring and the flexible catheter tube and spaced from the first closed portion and the second closed portion;
a metallic ball at the distal end of the catheter; and
a wire positioned within the flexible catheter tube for axially stiffening the flexible catheter tube and the helical coil spring, a distal end of the wire coupled to a distal end of the helical coil spring at the first closed portion via the metallic ball, a proximal end of the wire coupled to the helical coil spring at the second closed portion, a middle portion of the wire extending along an entirety of the at least one open portion.

US Pat. No. 10,188,420

AORTIC PUNCH

Medline Industries, Inc.,...

1. An aortic punch comprising:a first body member having a proximal end and a distal end;
a second body member disposed at least partially within said first body member;
a manual actuator;
a piston having an anvil disposed at a distal end thereof; and
a shear, said shear being integral with said second body member;
wherein the first body member and second body member are axially movable relative to one another between a fully extended position and a fully retracted position and within a range of intermediate positions while maintaining the piston and shear in position relative to each other in the axial direction,
wherein separately the shear is axially movable via manual actuation relative to said anvil between an insertion position and a shearing position and a range of intermediate positions, andwherein said piston includes external threads and wherein said first body member includes an internal surface with internal threads, the external threads of the piston engaging the internal threads of the internal surface of the first body member.

US Pat. No. 10,188,419

VISUALIZATION DEVICES FOR USE DURING PERCUTANEOUS TISSUE DISSECTION AND ASSOCIATED SYSTEMS AND METHODS

InterVene, Inc., South S...

1. A method, comprising:intravascularly delivering a visualization catheter to a dissection site within a blood vessel, wherein the visualization catheter includes an imaging portion;
advancing a delivery catheter over the visualization catheter to the dissection site, wherein the delivery catheter includes a device lumen configured to receive a dissection assembly and an open trough, and wherein the delivery catheter is advanced to a position such that at least a portion of the open trough is longitudinally aligned with the imaging portion of the visualization catheter;
moving the visualization catheter longitudinally through a visualization lumen of the delivery catheter and through a channel of the trough;
generating images of portions of a length of the vessel with the imaging portion while moving the visualization catheter through the channel; and
positioning the imaging portion of the visualization catheter into longitudinal alignment with a distal terminus of the dissection assembly during wall dissection.

US Pat. No. 10,188,418

TREATMENT METHOD

OLYMPUS CORPORATION, Tok...

1. A treatment method for treating a living tissue by using an ultrasonic device, comprising:making the ultrasonic device come in contact with the living tissue in a state where a product of a pressing force of the ultrasonic device to the living tissue, an amplitude of an ultrasonic vibration caused by the ultrasonic device, and a resonance frequency of the ultrasonic device becomes a predetermined value;
notifying a user when a product of the pressing force, the amplitude, and the resonance frequency is equal to or more than 4700 (N ?m kHz); and
excising the living tissue in a state where the ultrasonic device is in contact with the living tissue.

US Pat. No. 10,188,417

PERCUSSIVE SURGICAL DEVICES, SYSTEMS, AND METHODS OF USE THEREOF

Tenjin, LLC, Brazoria, T...

1. A percussive surgical assembly for the placement of a cannulated surgical anchor, wherein said assembly comprises:a. an outer assembly characterized by (i) a proximal outer hub having proximal and distal ends, wherein the proximal end of said outer hub includes a first cooperating element, (ii) a distal tubular portion having proximal and distal ends and an elongate lumen extending therebetween, wherein the proximal end of said distal tubular portion is configured to engage the distal end of said outer hub and the distal end of said distal tubular portion includes a distally projecting element positioned and axially movable within said elongate lumen; and (iii) the cannulated surgical anchor mounted about a distal end of said distally projecting element; and
b. an inner assembly characterized by (i) a proximal inner hub having proximal and distal ends, wherein the proximal end of said inner hub includes a drive portion for transmitting rotational motion from an external shaver handpiece to said inner assembly, and the distal end of said inner hub includes a second cooperating element that engages said first cooperating element, and (ii) a distal portion comprising an elongate driving rod slidably positioned and rotationally and axially movable within said elongate lumen of said distal tubular portion of said outer assembly;wherein:the proximal end of the outer hub is connected to the distal end of the inner hub; and
the drive portion of the inner hub further comprises an elastic member that transmits an axial force distally on the inner hub to maintain the engagement of said first and second cooperating elements when said inner hub and said outer hub are connected;whereby:rotation of the inner assembly relative to the outer assembly drives an interaction between said first and second cooperating elements which causes the inner assembly to move axially from a first extended position to a second retracted position while simultaneously compressing said elastic member; and
rotation of the respective inner and outer assemblies past a pre-determined stop limit results in a release of the compressed elastic member, which, in turn, propels the inner assembly in a distal direction such that a distal end of the driving rod strikes a proximal end of the distally projecting element with a percussive force sufficient to move the distally projecting element axially in the distal direction which, in turn, drives said cannulated surgical anchor into a prepared bone socket.

US Pat. No. 10,188,416

BIFURCATED FORCEPS

1. A bifurcated forceps, comprising a first pair of forceps arms and a second pair of forceps arms, each of the forceps arms having a pivot end and a gripping end, the pivot ends of the first and second pairs of forceps arms being resiliently coupled to each other at the pivot ends, the first and second pairs of forceps arms being biased to an open position in which the gripping ends are separated from each other and resiliently pivotal towards each other in a gripping plane in order to grip an object between the gripping ends, the pivot ends of the two arms in each of the pairs being pivotal around a common pivot axis in a rotational plane orthogonal to the gripping plane, whereby the first pair of forceps arms and the second pair of forceps arms may be rotated to spaced radial positions in order to grip the same object at spaced apart positions, wherein the second pair of forceps arms comprises an inner pair of forceps, the pivot ends of the second pair of forceps arms being physically joined directly to each other, further wherein the first pair of forceps arms comprises first and second arms having their pivot ends on opposite sides of the pivot ends of the inner pair of forceps, the first pair of forceps arms defining an outer pair of forceps, whereby the forceps arms of the inner pair of forceps are constrained to rotate together around the common pivot axis, additionally wherein each of the forceps arms of the outer pair of forceps defines a receptacle, and each of the forceps arms of the inner pair of forceps defines a blade edge, the blade edges of the inner pair of forceps being disposed in the receptacles of the outer pair of forceps to lock the inner and outer pairs together so that the bifurcated forceps may be used as a single pair of forceps to grip an object at a single point.

US Pat. No. 10,188,414

TONGUE CLEANING DEVICE

1. A tongue cleaning device that is used for removing debris from a tongue; the device comprising:a handle and a head that includes a scraping wall that has a handle-facing inner surface, an outer surface disposed substantially opposite the handle-facing inner surface, and a bottom surface extending between the handle-facing inner surface and the outer surface;
at least a portion of the head defining a debris-removal vacuum passage adapted to direct debris away from the head;
the scraping wall having a working edge that is usable to engage the tongue and remove debris from the tongue; the working edge being defined at the junction of the handle-facing inner surface and the bottom surface;
the head defining a curved trough above the handle-facing inner surface;
the head including a trough rear wall that defines the rear surface of the trough and a trough top wall;
the head defining a debris-removal vacuum inlet positioned to remove debris from the trough; the debris-removal vacuum inlet being at least partially defined by the trough rear wall such that debris can pass from the trough through the trough rear wall into the debris-removal vacuum passage; and
the trough having a pair of rear ends; each of the rear ends is disposed rearward of the debris-removal vacuum inlet.

US Pat. No. 10,188,413

DEFLECTABLE GUIDE CATHETERS AND RELATED METHODS

Acclarent, Inc., Irvine,...

1. A method comprising:(a) advancing a guide catheter into a head of a patient along a first path through a nostril of the patient in a first direction, wherein the guide catheter comprises a longitudinally extending distal deflection portion, wherein the distal deflection portion of the guide catheter comprises a lumen extending therethrough to a distal opening and a resilient member, wherein the resilient member biases the lumen of the distal deflection portion to a first configuration;
(b) providing a proximal assembly coupled with the guide catheter and a pull member connected to a distal end of the resilient member, wherein the proximal assembly is located outside the patient's body when the distal deflection portion of the guide catheter is in the head of the patient, wherein the proximal assembly comprises a control member operatively connected to the pull member, wherein the control member is configured to proximally pull the pull member and the resilient member connected thereto in order to deflect the lumen of the distal deflection portion from the first configuration to a second configuration;
(c) positioning the distal deflection portion of the guide catheter at or near a desired location of a first anatomical structure within the head of the patient, wherein the head of the patient has an anatomy with the first anatomical structure defining a passageway, wherein the first anatomical structure prevents access to a second anatomical structure within the head via the first path;
(d) retracting the control member proximally to proximally pull the pull member in conjunction with the resilient member to thereby deflect the lumen of the distal deflection portion from the first configuration to the second configuration;
(e) moving the distal opening of the guide catheter along a second path in a second direction transverse to the first direction such that the distal deflection portion advances around the first anatomical structure of the anatomy such that the distal deflection portion is in contact with the first anatomical structure of the anatomy about the passageway and the distal opening aligns with the passageway of the anatomy; and
(f) advancing a guidewire through the deflected lumen of the guide catheter to contact or pass through the desired location and the second anatomical structure.

US Pat. No. 10,188,412

SNARE AUTO MICRO-LOCK

Cook Medical Technologies...

1. A surgical snare, comprising:an operating wire;
an outer sheath comprising a lumen extending therethrough, the operating wire disposed within the lumen; and
a frictional locking member operably coupled to the outer sheath;
wherein the frictional locking member is configured to prevent longitudinal movement of the operating wire with respect to the outer sheath when no inwardly directed radial force is applied to an external surface of the frictional locking member;
wherein the operating wire is configured to be longitudinally movable within the outer sheath when the inwardly directed radial force is applied to the external surface of the frictional locking member, wherein the frictional locking member is actuated by the inwardly directed radial force applied to the external surface of the frictional locking member.

US Pat. No. 10,188,410

POWER PARAMETERS FOR ULTRASONIC CATHETER

EKOS CORPORATION, Bothel...

1. A method of operating an ultrasonic catheter comprising:advancing a catheter with at least one ultrasonic element to a treatment site in a patient's vascular system;
driving the at least one ultrasonic element to generate ultrasonic energy;
delivering a therapeutic compound to the treatment site through the catheter; and
non-linearly varying a power parameter of the at least one ultrasonic element, wherein the power parameter is selected from the group consisting of peak power, pulse repetition frequency, pulse width, and pulse repetition interval,
wherein the peak power is randomly or pseudo randomly distributed between a bounded maximum peak power Pmax and a bounded minimum peak power Pmin,
wherein the pulse repetition frequency is varied randomly between a bounded maximum pulse repetition frequency and a bounded minimum pulse repetition frequency,
wherein the pulse width is varied randomly within a bounded range, and
wherein the pulse repetition interval is varied randomly within a bounded range.

US Pat. No. 10,188,404

ORTHOPEDIC INSTRUMENTATION

8. An apparatus, comprising:a reamer sleeve having a reamer wall and a wedge body, the reamer wall oriented about a central longitudinal axis, the reamer wall having an inner passage sized to receive insertion of a reference instrument structured for placement in a canal of a bone, the wedge body extending from a first end wall of the reamer wall, the wedge body having a wedge surface that extends axially in a direction arranged non-parallel and non-perpendicular to the central longitudinal axis; and
a cap having an inner wall, at least a portion of the inner wall defines an opening of the cap sized to receive insertion of the wedge body, the inner wall having a tapered wall section that extends axially in a direction arranged generally parallel to the wedge surface;
wherein an outer side of the reamer wall is sized to be received within a portion of a forming tool adapted to remove bone material, and wherein the cap and the reamer sleeve are adapted to be introduced in the canal of the bone;
wherein during an initial stage of installation, the cap has a first position relative to the reamer sleeve and the wedge body;
wherein the reamer sleeve is adapted to be axially displaced relative to the cap with the wedge body having a second position relative to the tapered wall section of the cap, and wherein the reamer sleeve is adapted to be securely coupled to the cap in the second position; and
wherein the inner passage is centrally positioned about a longitudinal axis offset from the central longitudinal axis of the reamer wall.

US Pat. No. 10,188,403

BONE MATERIAL REMOVAL DEVICES

1. A method for forming a bore in a bone, and/or widening at least a portion of the bore, comprising:inserting a bone material removal device into a bore formed in a bone, said device comprising;
an elongated shaft having a recess and a longitudinal axis;
at least one bone material removal element having a proximal side and a distal side, said bone material removal element coupled to said shaft, wherein a length of said at least one bone material removal element perpendicular to the axis of said elongated shaft is longer than a diameter of said elongated shaft;
said bone material removal element movable from a closed position, in which said bone material removal element is at least partially received within the recess of said shaft, to an open position in which said bone material removal element extends radially away from said shaft; wherein an adjoining portion of said shaft adjoining both proximal and distal sides of the bone material removal element defines a generally cylindrical volume of rotation, and at least a portion of said bone removal element extends radially beyond said volume of rotation when said bone material removal element is in said closed position;
rotating said shaft to rotate said bone material removal element with respect to said shaft around an axis substantially parallel a longitudinal axis of said cylindrical volume of rotation such that said bone material removal element moves along a trajectory within a plane substantially perpendicular to the longitudinal axis of the cylindrical volume of rotation from said closed position to said open position as a result of resistance of the walls of said bore acting on said element; and
pulling said device through said bore in a direction opposite to the insertion direction to widen at least a portion of said bore using the opened bone material removal element.

US Pat. No. 10,188,402

INTRAOPERATIVELY ADJUSTING GUIDE ALIGNMENT

4. An alignment guide, comprising:a main body, the main body having a guide mount, a lower portion, and an upper portion, the guide mount having a hole; and
a retaining guide, the retaining guide includes at least one horizontal rod, the at least one horizontal rod connected to a crossbar, a bone mount connected to the cross bar by at least one vertical bar, a shaft extends between the cross bar and the bone mount, each end of the shaft terminates in a sliding block, and the sliding blocks received in slots of the crossbar and the bone mount, wherein the hole of the main body is configured to receive the shaft of the retaining guide.

US Pat. No. 10,188,401

SURGICAL DEVICES FOR INTERVENTIONAL ORTHOPEDIC SURGICAL APPLICATIONS AND PROSTHETIC TRIAL DEVICES AND METHODS OF MAKING THE SAME

ZJ, LLC, Whitmore Lake, ...

1. A surgical cut guide comprising:a first end including a first bone tissue engaging surface and at least one bone tissue fastener hole extending through the first bone tissue engaging surface, the first bone tissue engaging surface being configured to engage bone tissue;
a second end including second bone tissue engaging surface and at least one bone tissue fastener hole extending through the second bone tissue engaging surface, the second bone tissue engaging surface being angled relative to the first bone tissue engaging surface and configured to engage an anterior portion of the bone tissue;
a body extending between and connecting the first end and the second end, the body including a third bone tissue engaging surface angled relative to the first bone tissue engaging surface and the second bone tissue engaging surface;
a first projection defined by an interior portion of the body that bends away from the third bone tissue engaging surface, the first projection including a first guide surface angled relative to the third bone tissue engaging surface and defining a first guide path for guiding a cutting instrument;
a second projection and a third projection defined by respective interior portions of the second end of the surgical cut guide that each bend away from the first bone tissue engaging surface, the second projection including a second guide surface angled relative to the first bone tissue engaging surface and defining a second guide path for guiding the cutting instrument, the third projection including a third guide surface angled relative to the first bone tissue engaging surface and defining a third guide path for guiding the cutting instrument, the second projection and the third projection being arranged such that the second guide surface faces the third guide surface and the second guide surface is parallel to the third guide surface.

US Pat. No. 10,188,400

INTRALUMINAL OCCLUDING CATHETER

University of South Flori...

1. An intraluminal occluding catheter for prevention of loss of insufflation comprising:a catheter shaft comprising
an exterior surface;
an interior surface defining a single, undivided inner lumen;
a distal section terminating at an intraluminal end;
a plurality of orifices disposed in the distal section of the catheter shaft; and
a proximal section terminating at an external end;
a flexible balloon affixed to the intraluminal end wherein the intraluminal end of the catheter extends through an inner lumen of the flexible balloon whereby the flexible balloon is capable of conforming to a size and shape of a physiological lumen when filled with gas or fluid;
a plurality of independent channels each having a proximal end, a distal end, and a wall extending between the proximal and distal ends wherein the plurality of independent channels extend through the single, undivided inner lumen of the catheter shaft and positioned adjacent to each other within the single, inner lumen of the catheter shaft;
a sleeve attached to the external end of the catheter shaft wherein the plurality of independent channels extend through a proximal end of the sleeve and into the single, undivided inner lumen of the catheter shaft wherein the sleeve is tapered from the proximal end to a distal end of the sleeve;
a flow control device positioned at the proximal end of each of the plurality of independent channels wherein the flow control device is a valve or a stopcock; and
an insufflator attached to the flow control device of one independent channel of the plurality of independent channels;
wherein the distal end of each channel has at least one aperture disposed along a circumference of the wall of the corresponding channel therein;
wherein each aperture is substantially aligned with a corresponding orifice in a circumference of the catheter shaft;
wherein the at least one aperture of a first independent channel of the plurality of independent channels and the corresponding orifice in the circumference of the catheter shaft is disposed within the flexible balloon;
wherein the at least one aperture of a second independent channel of the plurality of independent channels and the corresponding orifice in the circumference of the catheter shaft is disposed immediately proximal to, but outside of, the flexible balloon; and
wherein the at least one aperture of a third independent channel of the plurality of independent channels and the corresponding orifice in the circumference of the catheter shaft is disposed proximal to the at least one aperture of the second channel and thus farther from the flexible balloon.

US Pat. No. 10,188,399

METHOD AND APPARATUS FOR TREATING A CAROTID ARTERY

Silk Road Medical, Inc., ...

1. A method of treating a lesion in a carotid artery of a patient, comprising:inserting an arterial access device into an artery through an arterial access location;
positioning at least a portion of the arterial access device into a common carotid artery;
occluding blood flow in at least a portion of the common carotid artery to form a pressure gradient that establishes retrograde blood flow through the common carotid artery such that blood flows into a lumen of the arterial access device;
in addition to establishing retrograde blood flow, actively pumping blood from the common carotid artery to a return location via the arterial access device and a shunt connected to the arterial access device, wherein the arterial access device comprises an elongate member defining an internal lumen that extends from a distal opening at a distal region of the arterial access device to a proximal opening at a proximal region of the arterial access device, wherein the internal lumen receives blood flow through the distal opening from the common carotid artery, and wherein the shunt comprises a sidearm connected to the arterial access device at a location between the distal and proximal openings of the arterial access device, and wherein the shunt provides a pathway for blood to flow out of the internal lumen of the arterial access device at a location between the distal and proximal openings of the arterial access device; and
treating the lesion by deploying a stent on the lesion.

US Pat. No. 10,188,398

CROSS-SECTIONAL MODIFICATION DURING DEPLOYMENT OF AN ELONGATE LUNG VOLUME REDUCTION DEVICE

PneumRx, Inc., Santa Cla...

1. A lung implant comprising:an elongate body having a proximal end, a distal end, and a length therebetween;
the elongate body further including:
a first self-expandable member at a first location on a proximal portion of the elongate body, the first self-expandable member having a collapsed configuration and an expanded configuration, wherein the first self-expandable member is configured to be constrained in the collapsed configuration by a lumen of a delivery catheter during delivery of the lung implant to a target area of the lung, wherein the first self-expandable member is configured to self-expand laterally toward the expanded configuration upon release from the delivery catheter in the airway, and wherein the first self-expandable member is configured to laterally engage the airway in the expanded configuration; and
a second self-expandable member at a second location on a distal portion of the elongate body, the second self-expandable member having a collapsed configuration and an expanded configuration, wherein the second self-expandable member is configured to be constrained in the collapsed configuration by the lumen of the delivery catheter during delivery of the lung implant to the target area of the lung, wherein the second self-expandable member is configured to self-expand laterally toward the expanded configuration upon release from the delivery catheter in the airway, and wherein the second self-expandable member is configured to laterally engage the airway in the expanded configuration;
wherein the lung implant comprises a deliverable configuration and a deployed configuration, the deliverable configuration comprising the first self-expandable member at the first location on the proximal portion of the elongate body in the collapsed configuration and the second self-expandable member at the second location on the distal portion of the elongate body in the collapsed configuration and the deployed configuration comprising the first self-expandable member at the first location on the proximal portion of the elongate body in the expanded configuration and the second self-expandable member at the second location on the distal portion of the elongate body in the expanded configuration.

US Pat. No. 10,188,397

TORQUE ALLEVIATING INTRA-AIRWAY LUNG VOLUME REDUCTION COMPRESSIVE IMPLANT STRUCTURES

PneumRx, Inc., Santa Cla...

1. A lung volume reduction system for enhancing a breathing efficiency of a patient with an airway, the system comprising:an implantable device having an elongate body including a proximal end and a distal end, the implantable device further having a first configuration and a second configuration, the second configuration of the implantable device corresponding to a configuration of the implantable device pre-implantation or post-implantation, the second configuration comprising at least one helical section;
wherein the at least one helical section includes a proximal portion, a distal portion, and a helical axis, the proximal portion and the distal portion of the at least one helical section configured to compress lung tissue disposed between the proximal portion and the distal portion;
wherein the elongate body transitions from the at least one helical section to a stand-off proximal tail at the proximal end of the elongate body, the stand-off proximal tail comprising a distal portion adjacent to and bending from the at least one helical section, a proximal portion, and a bend disposed between the distal portion and the proximal portion.

US Pat. No. 10,188,396

APPARATUS AND METHOD FOR DELIVERING AN EMBOLIC COMPOSITION

Covidien LP, Mansfield, ...

1. A microcatheter for delivery of embolic fluids, which comprises:an outer member dimensioned for insertion within a blood vessel adjacent an embolization site, the outer member defining a first longitudinal lumen;
an inner member selectively positionable within the first longitudinal lumen of the outer member, the inner member defining a second longitudinal lumen and having a delivery port in fluid communication with the second longitudinal lumen for passage and delivery of embolic fluids toward the embolization site; and
a valve disposed within the outer member, the valve dimensioned to establish a substantial seal about the inner member, to minimize entry of the embolic fluids within the first longitudinal lumen of the outer member subsequent to delivery thereof toward the embolization site,
wherein the outer member includes an expandable member disposed on an exterior wall surface thereof adjacent the delivery port, the expandable member dimensioned to expand and engage an interior wall portion of the blood vessel to at least partially isolate the embolization site.

US Pat. No. 10,188,395

NON-PLANAR HEATING CHAMBER DETACHMENT MECHANISM OF AN IMPLANTABLE VASO-OCCLUDING DEVICE DELIVERY SYSTEM

DEPUY SYNTHES PRODUCTS, I...

1. A delivery system for an implantable vaso-occluding device, comprising:an advancing member having a distal end and an opposite proximal end;
a non-planar heating chamber disposed proximate to the distal end of the advancing member; the non-planar heating chamber having an interior surface facing away from the distal end of the advancing member and an opposite exterior surface facing the distal end of the advancing member;
a detachment fiber made from a polymeric material and having a closed distal end protruding from the interior surface of the non-planar heating chamber; and
at least one heating element disposed on the interior surface of the non-planar heating chamber; the at least one heating element producing heat sufficient to sever the detachment fiber.

US Pat. No. 10,188,394

STAPLES CONFIGURED TO SUPPORT AN IMPLANTABLE ADJUNCT

Ethicon LLC, Guaynabo, P...

1. A staple cartridge assembly, comprising:a staple cartridge body, comprising:
a deck; and
staple cavities defined in said deck;
staples removably stored in said staple cavities, wherein each said staple is stamped from a sheet of material and comprises:
a base defining a base plane;
a leg extending from said base; and
a platform folded out of said base plane to extend laterally from said base; and
an implantable layer positioned over said deck, wherein said platforms of said staples are configured to abut said implantable layer when said staples are implanted into the tissue of a patient.

US Pat. No. 10,188,392

GRASPING FOR TISSUE REPAIR

Abbott Cardiovascular Sys...

1. A fixation device for engaging tissue comprising:a pair of distal elements each having a first end, a free end opposite the first end, and an engagement surface therebetween, the pair of distal elements having an open position and a closed position;
a pair of proximal elements each having a first end, a free end opposite the first end, and an engagement surface therebetween, the pair of proximal elements configured to be raised from and lowered toward the distal elements; and
a shaft to which the first ends of the proximal elements and distal elements are operably coupled;
wherein each of the distal elements comprises a retaining element joined to and extending from a location proximate the free end of the distal element, the retaining element being configured to permit tissue to move toward the first end of the distal element and to resist movement of the tissue away from the first end of the distal element, the retaining element extending along substantially an entire length of the distal element from proximate the free end towards the first end of the distal element when in the closed position,
wherein the retaining elements comprise at least one leaf spring configured to direct or urge the tissue toward engagement with one or more barbs located on one of the proximal elements.

US Pat. No. 10,188,391

BATTERY POWERED SURGICAL INSTRUMENT

Covidien LP, Mansfield, ...

1. A powered endoscopic surgical stapling apparatus, comprising:a handle assembly including:
a handle; and
a trigger movable in relation to the handle;
an endoscopic portion extending distally from the handle of the handle assembly;
an end effector assembly coupled to a distal end portion of the endoscopic portion, the end effector assembly configured to perform a first surgical function in response to an actuation of the trigger;
a motor for driving the surgical function;
a battery operably coupled to the motor;
a protecting housing configured to be releasably coupled to the handle of the handle assembly, wherein both the motor and the battery are disposed within the protective housing; and
a hand actuated control member supported on the handle and mechanically connected to the end effector assembly, wherein the end effector assembly is configured to perform a second surgical function upon actuation of the hand actuated control member.

US Pat. No. 10,188,390

ADJUNCT MATERIAL TO PROVIDE HETEROGENEOUS DRUG ELUTION

Ethicon LLC, Guaynabo, P...

1. A staple cartridge assembly for use with a surgical stapler, comprising:a cartridge body having a plurality of staple cavities, each staple cavity having a surgical staple disposed therein;
a biocompatible adjunct material releasably retained on the cartridge body and configured to be delivered to tissue by deployment of the staples in the cartridge body, the adjunct material having a top side, a bottom side disposed opposite of the top side, and a plurality of distinct regions, wherein each region is at a different location on the adjunct material and each region has a different adjunct construction, the plurality of distinct regions comprising
a first region located on the top side of the adjunct material,
second and third regions each located on the bottom side of the adjunct material,
a fourth region disposed between the second and third regions on the bottom side of the adjunct material, and
a fifth region located in an interior area of the adjunct material and configured to space apart the top and bottom sides of the adjunct material; and
a first medicant disposed within and releasable from the first region to discourage tissue growth, a second medicant disposed within and releasable from the second and third regions to encourage tissue growth, and a third medicant disposed within and releasable from the fourth region to facilitate hemostasis, each of the first, second, and third medicants being releasable from their respective regions in a non-homogeneous manner with respect to at least one of time of release and location of release.

US Pat. No. 10,188,389

ADJUNCT MATERIAL FOR DELIVERY TO COLON TISSUE

Ethicon LLC, Guaynabo, P...

1. A surgical device, comprising:a staple cartridge assembly for use with a surgical stapler, comprising:
a cartridge body having a plurality of staple cavities, each staple cavity having a surgical staple disposed therein;
a biocompatible adjunct material formed of a fiber matrix and releasably retained on the cartridge body and configured to be delivered to colon tissue by deployment of the staples in the cartridge body to form at least one line of deployed staples, the fiber matrix including a first plurality of longitudinal fibers and a second plurality of longitudinal fibers, the second plurality of longitudinal fibers extending transversely to the first plurality of longitudinal fibers and configured to detach from the first plurality of longitudinal fibers following the deployment of the staples; and
at least one medicant, the at least one medicant being releasable from the adjunct material, and the at least one medicant being effective to encourage a healing of blood vessels along the at least one line of deployed staples.

US Pat. No. 10,188,388

SURGICAL STAPLE INSERTION DEVICE

1. A staple inserter, comprising:an inserter body having a staple engagement structure at a first end portion thereof, wherein the staple engagement structure is configured for having at least one of staple legs and a staple bridge engaged therewith and wherein the staple engagement structure is selectively moveable for enabling a contact surface of an impingement structure of the inserter body at least partially covered by the staple engagement structure to become fully exposed; and
a staple bridge deflecting structure moveably attached to the inserter body, wherein the staple bridge deflecting structure includes a control portion and a staple bridge engaging portion, wherein movement of the control portion from a first position to a second position causes the staple bridge engaging portion to correspondingly move from a retracted position and a staple bridge deflecting position with respect to the staple engagement structure.

US Pat. No. 10,188,386

SURGICAL STAPLER WITH ANVIL STATE INDICATOR

Ethicon LLC, Guaynabo, P...

1. A surgical instrument comprising:(a) a body;
(b) a shaft assembly extending distally from the body;
(c) a stapling head assembly located at the distal end of the shaft assembly, wherein the stapling head assembly comprises a distal surface, wherein the stapling head assembly is operable to drive an annular array of staples through openings formed in the distal surface;
(d) an anvil, wherein the anvil is configured to couple with the stapling head assembly;
(e) an anvil adjustment assembly, wherein the anvil adjustment assembly comprises a translating member, wherein the translating member is operable to translate relative to the body along a longitudinal axis to thereby adjust a gap distance between the anvil and the distal surface of the stapling head assembly;
(f) a first indicator assembly, wherein the first indicator assembly comprises:
(i) a first member comprising an array of markers, wherein the first member is configured to translate in response to translation of the translating member relative to the body, and
(ii) a second member, wherein the second member is configured to remain stationary relative to the body as the first member translates relative to the body,
wherein the first indicator assembly is configured to provide feedback indicating whether the gap distance is sized to release tissue from between the anvil and the distal surface based on positioning of the first member in relation to the second member; and
(g) a second indicator assembly comprising an arm pivotably coupled with the body, wherein the first member is configured pivot the arm relative to the body to indicate whether the gap distance is sized to staple tissue between the anvil and the distal surface based on position of the first member in relation to the arm.

US Pat. No. 10,188,385

SURGICAL INSTRUMENT SYSTEM COMPRISING LOCKABLE SYSTEMS

ETHICON LLC, Guaynabo, P...

1. A surgical instrument system, comprising:a handle; and
a shaft assembly removably attached to said handle, said shaft assembly comprising:
an end effector;
a release actuator comprising a lock, wherein said release actuator is movable between a proximal position and a distal position, wherein said lock is engaged with said handle when said release actuator is in said proximal position, and wherein said lock is disengaged from said handle when said release actuator is in said distal position; and
a latch operably engaged with said release actuator, wherein said latch is movable between a first position and a second position, wherein said release actuator is configured to rotate said latch from said first position to said second position when said release actuator is moved toward said distal position, wherein said latch comprises a catch configured to engage said handle when said latch is moved toward said second position, wherein said catch is disengaged from said handle upon an additional manipulation of said release actuator, and wherein said additional manipulation is in a proximal direction.

US Pat. No. 10,188,383

SUTURE CLIP DEPLOYMENT DEVICES

Edwards Lifesciences Corp...

1. A device for successively deploying a plurality of preloaded suture clips onto sutures, comprising:a proximal handle portion comprising an actuation mechanism;
a mandrel having an inner lumen for receiving sutures, a proximal end portion coupled to the actuation mechanism, and a distal end portion having a distal opening in communication with the inner lumen, wherein the mandrel defines an axial dimension extending between the distal end portion and the proximal end portion, and a radial dimension perpendicular to the axial dimension, and wherein the mandrel is configured to receive at least one suture extending through the distal opening and into the inner lumen; and
a plurality of annular suture clips mounted around the distal end portion of the mandrel, the annular suture clips being generally disk shaped and having a diameter oriented in the radial dimension and a thickness oriented in the axial dimension, wherein the thickness is smaller than the diameter;
wherein the actuation mechanism causes the mandrel to move proximally relative to the suture clips, such that a distal-most one of the suture clips slides off of a distal end of the mandrel and onto one or more sutures extending into the distal opening of the mandrel; and
wherein, after the distal-most one of the suture clips is deployed onto one or more sutures, the actuation mechanism causes the mandrel and a remaining portion of the suture clips to move distally relative to the handle portion such that a distal-most one of the remaining portion of the suture clips is ready to be successively deployed;
the device further comprising a retainer positioned at least partially around the mandrel and coupled to the actuation mechanism independently of the mandrel, the retainer configured to restrict the suture clips from moving proximally relative to the handle portion when the mandrel moves proximally relative to the handle portion;
wherein the retainer comprises at least one axially extending slot that includes a plurality of circumferentially extending notches.

US Pat. No. 10,188,379

END EFFECTOR FOR WOUND CLOSURE DEVICE

Ethicon LLC, Guaynabo, P...

1. A suture device comprising:a. an elongated suture body having a proximal end and a distal end; and
b. a composite end effector at said distal end, said composite end effector comprising:
i. a fixation tab having a length, width and thickness, and
ii. an overlying attachment piece, comprising a tab opening with a length, width and thickness,
wherein the overlying attachment piece further comprising a distal end and a pair of longitudinal slits terminating at the distal end of the overlying attachment piece,
wherein at least a proximal end of the fixation tab is inserted into said opening of said overlying attachment piece such that the proximal end of the fixation tab abuts a proximal wall of said overlying attachment piece while at least a distal end of the fixation tab extends axially outwardly from the overlying attachment piece and the fixation tab extends laterally outwardly from the overlying attachment piece through the pair of longitudinal slits.

US Pat. No. 10,188,378

MICROANCHOR

1. A suture anchor for soft tissue repair, the suture anchor comprising:a body having a proximal end engageable with a suture anchor insertion instrument, a distal end, a longitudinal axis extending between the proximal end and the distal end, and an outer surface extending between the proximal and distal ends;
a plurality of projections extending from the surface;
a first bore extending completely across the body transverse to the longitudinal axis;
a soft suture bridge threaded through the first bore and having first and second free ends extending proximally from the first bore; and
a repair suture threaded through apertures at each of the first and second free ends so as to engage with the first and second free ends of the soft suture bridge, wherein each of the first and second free ends structurally defines all boundaries of an eyelet which defines a discretely bounded aperture at that end, the repair suture being threaded through the eyelets;
wherein an initial size of each aperture is smaller than a cross-section of the repair suture and wherein each aperture is resiliently elastic such that a size thereof (i) increases when tension is applied to the repair suture thereby enabling the repair suture to slide relative to the aperture and (ii) decreases when tension is released thereby inhibiting the repair suture from sliding relative to the aperture.

US Pat. No. 10,188,376

TISSUE RETRACTOR

Edwards Lifesciences Corp...

1. A device for surgical retraction to create an opening in a patient, comprising:a main frame comprising a main frame proximal side and a main frame distal side, the main frame further comprising a central opening passing from the main frame proximal side to the main frame distal side, the main frame comprising an outer structure surrounding the central opening;
a plurality of movable arms extending from the outer structure and into the central opening, each movable arm comprising an arm proximal end connected to the outer structure and an arm distal end positioned in the central opening;
a plurality of legs, wherein one of said plurality of legs extends from each of the plurality of movable arms, wherein each of said plurality of legs comprises a leg proximal end secured to one of the plurality of movable arms, and each of said plurality of legs comprises a leg distal end, wherein each of said plurality of legs extends distally from the main frame distal side;
wherein the device comprises a closed configuration wherein the plurality of movable arms extends into the central opening and the plurality of legs are positioned toward a center portion of the central opening with the plurality of legs adjacent each other with the leg distal ends forming a substantially straight line therebetween when viewed from the main frame distal side, the device further comprising an open configuration wherein the plurality of movable arms are moved so that the arm distal ends are positioned at or adjacent an outer perimeter of the central opening with each of the plurality of legs spaced apart from the other legs so that the plurality of legs define a periphery having a polygonal shape, wherein each of the plurality of legs defines a corner of the polygonal shape.

US Pat. No. 10,188,370

ULTRASOUND IMAGING SYSTEM AND METHOD

Koninklijke Philips N.V.,...

1. An ultrasound imaging system, comprising:an ultrasound probe configured to acquire a sequence of ultrasound data of an imaging region of a subject when a contrast agent is perfused in the imaging region;
a time-intensity curve calculator configured to calculate a time-intensity curve of the contrast agent for each region unit of a plurality of region units of the imaging region, based on the acquired sequence of ultrasound data, each region unit comprising one or more points of the imaging region;
a reference selector configured to select, among the plurality of region units, a first, second and third set of region units respectively corresponding to normal tissue, vessel and background noise, based on the time-intensity curves, and wherein the reference selector is further configured to divide the imaging region into a plurality of segments, each segment being located at a different depth level and to select the one or more region units from the first set of region units, the one or more region units being located in the segment where the region of interest is located;
a perfusion parameter calculator configured to calculate a perfusion parameter for each of one or more region units of the first set of region units and a perfusion parameter for a region of interest in the imaging region, based on the calculated time-intensity curves;
a reference perfusion parameter calculator configured to calculate a reference perfusion parameter, based on the perfusion parameters of the one or more region units located in the segment where the region of interest is located; and
a ratio calculator configured to calculate a ratio value for the region of interest as a ratio of the perfusion parameter of the region of interest and the reference perfusion parameter.

US Pat. No. 10,188,369

METHODS AND APPARATUS FOR PERFORMING MULTIPLE MODES OF ULTRASOUND IMAGING USING A SINGLE ULTRASOUND TRANSDUCER

Clarius Mobile Health Cor...

1. An ultrasound imaging method comprising, by an ultrasound imaging machine:imaging in a first mode using a sequential transducer comprising a plurality of transducer elements, wherein when imaging in the first mode, groups of adjacent transducer elements of the plurality of transducer elements are sequentially pulsed for beamforming, and the groups of adjacent transducer elements correspond to respective different apertures along a head of the sequential transducer; and
imaging in a second mode different from the first mode, wherein when imaging in the second mode, a subset of at least two of the plurality of transducer elements form a single aperture on the head of the sequential transducer, and the subset of transducer elements are repeatedly pulsed with different phase shifts for beamforming through the single aperture so that a plurality of ultrasound signals are steered from the subset of the plurality of transducer elements, and wherein any remaining transducer elements of the plurality of transducer elements not part of the subset are inactive when imaging in the second mode.

US Pat. No. 10,188,368

IMAGE GUIDED INTRAVASCULAR THERAPY CATHETER UTILIZING A THIN CHIP MULTIPLEXOR

1. An intravenous ultrasound catheter having a distal tip and comprising:(a) a forward-facing array of ultrasound elements near to said distal tip of said device;
(b) an integrated circuit (IC) die, abutting and proximal to said ultrasound elements, having a thickness of less than 80 ?m, and having:
(i) a first face, facing said forward-facing array, and having an array of ultrasound element driving and receiving contacts, in mating arrangement to said array of ultrasound elements, so that said array of ultrasound element driving and receiving contacts collectively physically abut and electrically connect to each of said ultrasound elements;
(ii) a second face, opposed to said first face, and having a set of input-output signal contacts, said set being fewer in number than said array of ultrasound element driving and receiving contacts and being collectively switchable into contact with any one of a set of predefined blocks of said ultrasound element driving and receiving contacts, said second face also having a set of control contacts, wherein inputs received by said control contacts positively collectively command some aspect of operation of said IC die; and
(iii) wherein said ultrasound element driving and receiving contacts can send and receive signals from a first one of said blocks of said driving and receiving contacts and can then be switched to send and receive signals from a second one of said blocks of said driving and receiving contacts, different from said first one of said blocks;
(c) a flex circuit assembly, proximal to said integrated circuit and including coax cables and a contact portion, having a set of contact pads abutting and electrically connecting said input-output signal contacts of said IC die, to said coax cables;
(d) backing material, abutting and directly proximal to said contact portion, thereby forming an interface and wherein said backing material and said contact portion material have equal acoustic impedance, thereby preventing reflection at said interface; and
(e) a tubular flexible protective covering, covering said array of ultrasound elements, said integrated circuit die, said flex circuit assembly and said backing material.

US Pat. No. 10,188,362

X-RAY FLUOROSCOPY AND IMAGING APPARATUS

SHIMADZU CORPORATION, Ky...

1. An X-ray fluoroscopic imaging apparatus, comprising:an image generation element that generates a fluoroscopic image based on a detection signal of a radiation that transmits through a subject;
a display element that enables a display of said fluoroscopic image and displays said fluoroscopic image;
an image processing element that executes an image processing to superimpose a plurality of said fluoroscopic images that said image generation element continuously generates and generates an image denoting a movement locus of a benchmark denoting a location of a device introduced inside a body of said subject; and displays said image on said display element;
a region-of-interest setting element that defines and displays a region-of-interest that includes said movement locus relative to a superimposed image of said fluoroscopic images;
the region-of-interest being initially based on four user-specified location points that surround the movement locus; and
said benchmark is detected in the region-of-interest after the region-of-interest is defined by the region-of-interest setting element.

US Pat. No. 10,188,360

VIDEO AND ACCESSORY APPARATUS FOR A VIDEOFLUOROSCOPY UNIT

1. A videofluoroscopy accessory for use with a videofluoroscopy device or system, the videofluoroscopy accessory comprising:a clamp adapted to receive an X-ray head of a videofluoroscopy device,
at least one accessory mount disposed on the clamp adapted to removably receive at least one predetermined accessory,
at least one predetermined accessory,
wherein the at least one predetermined accessory is a video camera, and
wherein the at least one accessory mount is configured to enable selectively positioning of the accessory in any direction during operation of the X-ray head.

US Pat. No. 10,188,358

SYSTEM AND METHOD FOR SUBJECT SHAPE ESTIMATION

General Electric Company,...

1. A non-transitory computer readable storage medium having stored thereon a computer program comprising instructions, which, when executed by a computer, cause the computer to:acquire shape estimation information with a shape estimation system that includes a plurality of light emitting sources distributed circumferentially about a bore of a gantry and a plurality of light detectors distributed circumferentially about the bore of the gantry, wherein the light emitting sources are arranged in at least two rings disposed about the bore of the gantry, wherein the at least two rings include a first ring and a second ring disposed on opposite sides of at least one detector unit attached to the gantry, wherein each light emitting source emits light at a different time instance, wherein the gantry does not include an x-ray tube;
emit light from the at least two rings of the light emitting sources disposed about the bore of the gantry;
detect which light detectors, attached with the bore of the gantry, received each instance of emitted light at each time instance;
determine a subject shape estimation of a subject of a medical imaging system with the information, wherein the subject shape estimation is of an external outline of a subject being imaged;
develop an image acquisition scenario with the subject shape estimation and a requested imaging operation;
configure a physical location of the at least one detector unit attached to the gantry based on the developed image acquisition scenario; and
acquire Single Photon Emission Computed Tomography (SPECT) image information with the at least one detector unit, wherein the at least one detector unit used to acquire the SPECT image information is distinct from the shape estimation system.

US Pat. No. 10,188,357

SUPPORT UNIT, SUPPORT DEVICE, AND EMISSION TOMOGRAPHY DEVICE USING SUPPORT DEVICE

1. A support unit for an emission tomography device, characterized in that it comprises:a support body, provided with an accommodation space running through the support body therein, wherein the support body comprises a plurality of support positions that are distributed along a circumferential direction of the accommodation space;
a plurality of fastening means, connected to at least a portion of the plurality of support positions, for fixing detectors of the emission tomography device, wherein at least a portion of the plurality of fastening means are movable between contraction positions and extension positions along radial directions of the accommodation space,
wherein the fastening means are used for forming a first detector fastening ring with a first diameter when at the contraction positions and forming a second detector fastening ring with a second diameter which is smaller than the first diameter when at the extension positions,
wherein the plurality of support positions are configured that when a predetermined number of the support units are arranged side by side along the axial direction of the accommodation space, support positions on different support units are staggered and arranged alternately along the circumferential direction, in order for the fastening means on the predetermined number of the support units to form the first detector fastening ring alternately.

US Pat. No. 10,188,351

ELECTROCARDIOGRAM (ECG) SIGNAL BASED AUTHENTICATION APPARATUS AND METHOD

Samsung Electronics Co., ...

1. An authentication apparatus comprising:one or more processors configured to
implement a neural network comprising an input layer comprising N input nodes and a hidden layer comprising hidden nodes, wherein the hidden layer is connected to the input layer;
group the input nodes into input node sets comprising M input nodes, wherein M is less than N,
wherein each input node set is connected to a single respective hidden node, and
wherein each hidden node of the hidden nodes is connected to a single respective input node set;
assign a first weight set comprising weights to each input node set of the input node sets;
calculate a respective feature value for each hidden node based on the respective input node set connected to the each hidden node and the first weight set;
determine at least one output feature value based on the respective feature value for each hidden node; and
register a user in association with an input electrocardiogram (ECG) signal and the at least one output feature value,
wherein the first weight set is the same weight set applied to every input node set of the input node sets.

US Pat. No. 10,188,347

ENERGY EXPENDITURE DEVICE

NIKE, Inc., Beaverton, O...

1. A computer-implemented method comprising:obtaining, by a computing device and from one or more sensors, movement data of a first user along a plurality of axes for a first time period and a second time period;
for each time period, classifying, based at least on a type of the one or more sensors, the movement data of the first user into one of a plurality of predefined activity categories;
calculating, based upon the movement data and the activity category the movement data was classified into, a first energy expenditure value for the first time period and a second energy expenditure value for the second time period;
receiving movement data of a second user along a plurality of axes for a third time period and a fourth time period;
for each time period, classifying the movement data of the second user into one of the plurality of predefined activity categories;
calculating an energy expenditure value for the third time period and the fourth time period based upon the movement data and the activity category the movement data was classified into:
determining one or more derivatives of the energy expenditure values obtained during a unitary time frame that includes the first time period and the second time period to determine a first energy expenditure intensity value;
determining the energy expenditure values obtained during the time frame that includes the third time period and the fourth time period to obtain a second energy expenditure intensity value; and
displaying, using the computing device, a representation of the determined energy expenditure values and representations of the first energy expenditure intensity value and the second energy expenditure intensity value.

US Pat. No. 10,188,344

OPTIMUM ADMINISTRATION FORM PROVIDING SYSTEM FOR MAGNETIC DRUG

IHI Corporation, Tokyo (...

1. A system to provide a modified administration form for a magnetic drug, the system comprising:a memory;
a processor configured to;
obtain equipment analysis information including internal body image data after administering the magnetic drug based on an administration form of the magnetic drug, the administration form including a trial dose of the magnetic drug, wherein the magnetic drug comprises a metal salen complex compound for a brain tumor, and the internal body image data includes X-ray CT image data of organs and MRI image data showing a distribution status of the magnetic drug in the organs as a gray-scaled image,
determine a first concentration about a side-effect-related organ on which the magnetic drug produces a side effect, based on the internal body image data by:
determining a first volume value of the side-effect- related organ from X-ray CT image data of the side- effect-related organ, and
calculating the first concentration of the magnetic drug in the side-effect-related organ, wherein the calculating of the first concentration including:
calculating a magnetic drug density data in the side-effect-related organ from an MRl image data, showing a distribution status of the magnetic drug in the side-effect-related organ, and
multiplying the calculated magnetic drug density data in the side-effect-related organ and the first volume value of the side-effect-related organ to obtain the first concentration,
determine a second concentration about a drug-efficacy-related organ in which drug efficacy of the magnetic drug by:
determining a second volume value of the drug- efficacy-related organ from X-ray CT image data of the drug-efficacy-related organ, and
calculating the second concentration of the magnetic drug in the drug-efficacy-related organ, wherein the calculating of the second concentration including:
calculating a magnetic drug density data in the drug efficacy-related organ from an MRI image data showing a distribution status of the magnetic drug in the drug-efficacy-related organ, and
multiplying the calculated magnetic drug density data in the drug-efficacy-related organ and the second volume value of the drug-efficacy-related organ to obtain the second concentration,
evaluate the administration form of the magnetic drug based on the first concentration and the second concentration by scoring the first concentration and the second concentration in accordance with a predetermined threshold value,
determine, based on the evaluation, an integrated correction coefficient that associates a side-effect of the magnetic drug with a drug efficacy of the magnetic drug, the determining of the integrated correction coefficient including prioritizing a reduction of the side effect of the magnetic drug, and
generate the modified administration form of the magnetic drug that reflects the side-effect of the magnetic drug and the drug efficacy of the magnetic drug based on the integrated correction coefficient, wherein the modified administration form includes an a modified dose of the magnetic drug calculated by multiplying the integrated correction coefficient and the trial dose of the magnetic drug; and
an output device that displays the modified administration form.

US Pat. No. 10,188,342

METHODS, APPARATUSES AND SYSTEMS FOR TRANSCRANIAL STIMULATION

THE UNIVERSITY OF NORTH C...

1. A method of modulating cortical activity in a subject, comprising:detecting cortical oscillations and/or coherence between cortical oscillations in the subject via an electrocardiogram, a pupilometer and/or a functional near-infrared spectrometer; and
passing an oscillating electric current through the skull of the subject responsive to the cortical oscillations and/or coherence detected.

US Pat. No. 10,188,340

SEM SCANNER SENSING APPARATUS, SYSTEM AND METHODOLOGY FOR EARLY DETECTION OF ULCERS

Bruin Biometrics, LLC, L...

1. A Sub-Epidermal Moisture (SEM) sensing apparatus, comprising:a flexible substrate,
a first electrode and a second electrode that are both disposed on a common side of the flexible substrate, and
an electronics package that is individually wired to each of the first and second electrodes and configured for independent interrogation, excitation, and data retrieval and further configured to measure a sub-epidermal capacitance of a target region of skin between the first and second electrodes, the sub-epidermal capacitance corresponding to the moisture content of the target region.

US Pat. No. 10,188,338

CONTENT EVALUATION SYSTEM AND CONTENT EVALUATION METHOD USING THE SYSTEM

NHN Entertainment Corpora...

1. A method of evaluating media content, the method comprising:sorting and storing evaluation standard data in a database according to a criteria comprising at least one of type of a media content, age of a subject, or sex of the subject;
exposing the subject to the media content at a second time;
detecting a brainwave signal of the subject at a first time and at the second time with a brainwave detector cap worn on the subject's head;
detecting a bio signal of the subject at the first time and at the second time, wherein the bio signal includes a facial electromyogram and at least one of a galvanic skin response, a heart rate, a body temperature, or a respiration of the subject;
obtaining images of the subject at the first time and at the second time; and
receiving the brainwave signal detected at the first time, the bio signal detected at the first time, and the image obtained at the first time with a controller;
receiving the brainwave signal detected at the second time, the bio signal detected at the second time, and the image obtained at the second time with the controller;
determining a change in the brainwave signal between the first time and the second time, with the controller;
determining a change in the bio signal between the first time and the second time, with the controller;
determining a degree of engagement and a degree of an emotional reaction of the subject to the content using the change in the brainwave signal and the change in the bio signal, with the controller;
analyzing a movement of the subject from the images of the subject at the first time and at the second time to provide analyzed results, with the controller;
verifying the determined degree of engagement and the emotional reaction of the subject using the analyzed results, including removing motion noise due to drowsiness, unconscious movements or reflex movements from the brainwave signal and the bio signal, with the controller;
evaluating the content exposed to the subject at the second time based on the degree of the engagement and the emotional reaction according to the evaluation standard data that is stored in the database, with the controller; and
updating the evaluation standard data stored in the database based on the step of evaluating the content.

US Pat. No. 10,188,336

PUNCTURE NEEDLE SENSOR MANUFACTURING METHOD

TERUMO KABUSHIKI KAISHA, ...

1. A puncture needle manufacturing method comprising:forming an insulation layer and a plurality of spaced apart elongated electrodes on a metal sheet so that the electrodes overlie the insulation layer;
cutting the metal sheet, the insulation layer, and a portion of the electrodes on the metal sheet to form a plate-shaped body, the plate-shaped body possessing a proximal end, a distal end, and a middle portion, the plate-shaped body having a width at the proximal end greater than a width at the distal end, and the middle portion of the plate-shaped body tapering in width towards the distal end;
press-working the plate-shaped body to form the plate-shaped body into a tubular body, the tubular body possessing an outer diameter at a distal end greater than an outer diameter at a proximal end; and
forming a pointed, beveled end portion at the distal end of the tubular body, wherein the press-worked tubular body possesses a distal portion and a proximal portion, the tubular body comprising:
a distal plurality of separate and circumferentially spaced apart electrodes fixed on the insulation layer in the distal portion of the tubular body;
a proximal plurality of separate and circumferentially spaced apart electrodes fixed on the insulation layer in the proximal portion of the tubular body; and
the distal plurality of electrodes being a different number of electrodes than the proximal plurality of electrodes.

US Pat. No. 10,188,333

CALIBRATION TECHNIQUES FOR A CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A system for continuous glucose sensing, the system comprising:an implantable continuous glucose sensor configured to generate sensor data associated with glucose concentration in a host; and
sensor electronics configured to:
apply a voltage to the implantable continuous glucose sensor at a first setting,
switch the voltage applied to the implantable continuous glucose sensor to a second setting, wherein the first setting is different from the second setting,
measure a signal response of the electrochemical glucose sensor responsive to a change in the voltage applied, wherein the signal response is associated with a sensitivity change of the implantable continuous glucose sensor,
calibrate the sensor data, wherein the calibrating accounts for the sensitivity change, and
generate at least one glucose concentration value based on the calibrated sensor data.

US Pat. No. 10,188,330

METHODS AND SYSTEMS FOR DETERMINING A LIGHT DRIVE PARAMETER LIMIT IN A PHYSIOLOGICAL MONITOR

Covidien LP, Mansfield, ...

1. A method for driving a medical sensor for use on a subject, comprising:generating a light drive signal with a variable current below a first maximum current limit, the light drive signal being configured to produce an emitted light in a medical sensor;
receiving a sensor signal from the medical sensor, in response to the emitted light;
determining a parameter based on the received sensor signal;
changing the maximum current limit based on the parameter; and
generating the light drive signal in accordance with the changed maximum current limit.

US Pat. No. 10,188,329

SELF-CONTAINED REGIONAL OXIMETRY

Nonin Medical, Inc., Ply...

1. A handheld device comprising:a contact surface coupled to a handle portion, the handle portion configured for gripping by a user;
an optical module disposed on the contact surface, the optical module having at least one optical emitter and at least one optical detector, the optical module having a light shield associated with a perimeter of the contact surface, the light shield configured to exclude ambient light from the contact surface when the contact surface abuts tissue of a patient, wherein the light shield includes a raised curb;
a processor coupled to the optical module and configured to execute instructions for determining a measure of oximetry corresponding to the tissue; and
a display module coupled to the processor and configured to indicate the measure of oximetry; and
a user operable switch configured to activate at least one of the processor, the optical module, and the display module.

US Pat. No. 10,188,326

FOLDOVER SENSORS AND METHODS FOR MAKING AND USING THEM

MEDTRONIC MINIMED, INC., ...

1. An analyte sensor apparatus comprising:a base substrate comprising a planar sheet of a flexible material adapted to transition from a first configuration to a second configuration when the base substrate is folded to form a fixed bend;
a working electrode, a counter electrode and a reference electrode disposed upon a first surface of the base substrate;
a plurality of contact pads disposed upon the first surface of the base substrate;
a plurality of electrical conduits disposed upon the first surface of the base substrate, wherein the plurality of electrical conduits are adapted to transmit electrical signals between the working electrode, the counter electrode or the reference electrode and the plurality of contact pads separated by the fixed bend;
an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; and
an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of analyte therethrough;wherein:the base substrate comprises the fixed bend so as to form an configuration characterized in that:
at least one working electrode, counter electrode or reference electrode is disposed on a first side of the fixed bend; and
at least one working electrode, counter electrode or reference electrode is disposed on a second side of the fixed bend.

US Pat. No. 10,188,322

METHOD AND APPARATUS FOR DETERMINING THE ORIENTATION OF AN ACCELEROMETER

KONINKLIJKE PHILIPS N.V.,...

1. A method of determining the orientation of an accelerometer that is being carried or worn by a user, the method comprising:measuring acceleration using the accelerometer as the user moves;
processing the measured acceleration to determine a step frequency of the movements by the user; and
processing the measured acceleration to identify a lateral component of acceleration as a component of acceleration having a high response at a frequency corresponding to half the step frequency.

US Pat. No. 10,188,317

MEASURING RESPIRATORY MECHANICS PARAMETERS USING PERTURBATIONS

1. A system for measuring one or more respiratory parameters comprising:an airflow perturbation device comprising:
a perturbation mechanism to periodically alter air flow resistance in a pathway at a plurality of different perturbation frequencies, wherein the perturbation mechanism includes an air flow path, an obstruction element disposed in the air flow path, and an actuator coupled to the obstruction element to control the obstruction element to obstruct air flow;
a pneumotachometer comprising a flow sensor to measure airflow in the pathway; and
a pressure sensor to measure a pressure in the pathway; and
a computing system comprising at least one processor configured to:
control the perturbation mechanism to operate at each of the plurality of different perturbation frequencies in succession;
receive data from the flow sensor and pressure sensor and determine a ratio of pressure changes to flow changes induced by the airflow perturbation device at each of the plurality of different perturbation frequencies to form a dataset of resistance of a respiratory system at each of the plurality of different perturbation frequencies; and
determine at least one respiratory parameter based on variations in the resistance over the different perturbation frequencies by fitting a curve defined by the resistance at each of the different perturbation frequencies to a predicted frequency dependence curve indicating contributions of respiratory parameters to resistance, wherein the at least one respiratory parameter includes a compliance of the respiratory system.

US Pat. No. 10,188,316

SYSTEMS AND METHODS FOR MODULAR INTRALUMINAL DEVICE POWER TRANSFER

Elwha LLC, Bellevue, WA ...

1. An intraluminal traveling modular system, comprising:a first intraluminal device, the first intraluminal device including
a body structure dimensioned and structured to travel through a biological lumen of a subject;
a sensor coupled to the body structure, the sensor oriented to detect at least one characteristic of the biological lumen and to generate one or more sense signals in response thereto;
a processor operably coupled to the sensor, the processor configured to receive the one or more sense signals;
a data transmitter coupled to the body structure and configured to wirelessly transmit one or more data signals associated with the one or more sense signals responsive to instruction by the processor; and
an energy storage module configured to power at least one of the sensor, the processor, or the data transmitter; and
a second intraluminal device, the second intraluminal device including
a second body structure dimensioned and structured to travel through the biological lumen of the subject;
an energy storage device coupled to the second body structure, the energy storage device configured to transfer energy stored in the energy storage device to the energy storage module of the first intraluminal device; and
a docking structure coupled to the second body structure, the docking structure configured to couple the first intraluminal device with the second intraluminal device, the energy storage device configured to transfer the energy when the first intraluminal device and the second intraluminal device are coupled via the docking structure, the docking structure further configured to automatically decouple the first intraluminal device and the second intraluminal device subsequent to transfer of the energy from the energy storage device of the second intraluminal device to the energy storage module of the first intraluminal device,
wherein the first intraluminal device further includes
a wall-engaging structure capable of engaging a wall of the biological lumen to secure the first intraluminal device with respect to the wall of the biological lumen; and
a second sensor configured to measure a proximity between the first intraluminal device and the second intraluminal device, and
wherein the processor is configured to direct the wall-engaging structure to secure the first intraluminal device with respect to the wall of the biological lumen until the measured proximity between the first intraluminal device and the second intraluminal device is within a threshold proximity.

US Pat. No. 10,188,315

INSERTION SYSTEM HAVING INSERTION PORTION AND INSERTION MEMBER

OLYMPUS CORPORATION, Tok...

1. An insertion system comprising:an insertion portion including at least a grasp portion and an insertion channel passing inside the insertion portion from a proximal end of the insertion portion to a distal end of the insertion portion, the insertion portion being configured to be inserted into a specimen;
an insertion member configured to be inserted into an insertion hole of the insertion channel on a side of the proximal end of the insertion portion, and projected from a side of the distal end of the insertion portion to extend into the specimen;
an optical pattern provided on an outer circumferential surface of the insertion member;
a first sensor disposed in the insertion hole of the insertion portion, the first sensor being configured to read the optical pattern of the insertion member inserted in the insertion channel and to detect an insertion amount of the inserted insertion member and a rotation amount of the insertion member around its central axis in the insertion portion; and
a processor comprising hardware, the processor being configured to calculate, from a detection result by the first sensor, the insertion amount, the rotation amount, and a position and a shape of a distal end of the insertion member inserted through the insertion channel.

US Pat. No. 10,188,314

SYSTEM AND METHOD FOR DETECTING SHEATHING AND UNSHEATHING OF LOCALIZATION ELEMENTS

St. Jude Medical, Cardiol...

1. A method of detecting a localization element/sheath state change with a localization system, comprising:establishing a localization field using a plurality of localization field generators;
obtaining a first localization signal from a first catheter-borne localization element positioned within the localization field via an introducer sheath, the first localization signal including a first in-phase component and a first quadrature component;
obtaining a second localization signal from a second catheter-borne localization element positioned within the localization field via the introducer sheath, the second localization signal including a second in-phase component and a second quadrature component;
comparing the second quadrature component to the first quadrature component; and
detecting a localization element/sheath state change for the second catheter-borne localization element based on the comparison between the second quadrature component and the first quadrature component.

US Pat. No. 10,188,312

DETECTING HEAD DEVICE FOR CAPACITIVELY MEASURING AN ACUPUNCTURE POINT FREQUENCY OF A HUMAN BODY

1. A detecting head device for capacitively measuring an acupuncture point frequency of a human body, comprising:a contact head, which comprises a first terminal (1,1?) that contacts with an acupuncture point (P2) of the human body to obtain a capacitance value CH of the acupuncture point (P2) and a second, terminal (2,2?) that is grounded;
an internal oscillator, which comprises an inductor L1 and a capacitor C2, and is configured to generate oscillations of a predetermined internal oscillation frequency F1 when the contact head does not contact the acupuncture point (P2) of the human body, and to generate oscillations of an oscillation frequency F2 when the contact head contacts the acupuncture point (P2) of the human body;
an electronic counter, which is connected to the internal oscillator and is configured to calculate the internal oscillation frequency F1; and
an external interrupt service routine (ISR), being connected to the electronic counter, in which when the contact head contacts with the acupuncture point (P2) of the human body, the external ISR-receives an acupuncture point frequency signal of the contacted human body and calculates, in combination with the internal oscillator producing the oscillation, a frequency F2 of the contacted acupuncture point of the human body based on the capacitance value CH of the acupuncture point (P2) of the human body as well as an inductance value of the inductor L1 and a capacitance value of the capacitor C1 of the internal oscillator, using mathematical formulas shown as follows:
and
wherein the inductor L1 and the capacitor C2 are oscillatory elements of the internal oscillator.

US Pat. No. 10,188,311

DEVICE TO REDUCE TRAUMATIC BRAIN INJURY

1. A device for reducing traumatic brain injury, the device comprising:a first sensor coupled to a head component configured to measure a motion value of a user's head as a result of motion of the head component and to generate a sequence of real-time measured samples;
a linkage element configured to connect the head component to a body component, the linkage element switchable between a first state in which the linkage element is relatively flexible and a second state in which the linkage element is relatively rigid based upon a locking signal; and
a processing element configured to receive the measured samples,
calculate a plurality of dynamic concussion thresholds, each dynamic concussion threshold associated with one of a plurality of sequential, time-based array cells, each array cell including a mean of historically-collected measured samples and a standard deviation of historically-collected measured samples from the first sensor, such that each dynamic concussion threshold is calculated as a sum of the mean and the standard deviation for the associated array cell,
compare a first measured sample to a first dynamic concussion threshold, a second measured sample to a second dynamic concussion threshold, and so forth in sequence, and
generate the locking signal when each one of a predetermined number of successive measured samples is greater than the corresponding successive dynamic concussion thresholds.

US Pat. No. 10,188,305

LOCATING J-POINTS IN ELECTROCARDIOGRAM SIGNALS

1. A method for locating a J-point in a cardiac cycle waveform, the method being implemented by one or more data processors forming part of at least one computing device, the method comprising:receiving electrocardiogram (ECG) data derived from an ECG electrode set affixed to a patient, the ECG data comprising a sequence of cardiac cycle waveforms that each correspond to a single cardiac cycle, each waveform comprising a series of samples;
locating, for each cardiac cycle waveform, an R-peak, an S-peak, and a T-peak;
calculating, for each cardiac cycle waveform, a Euclidian distance between the R-Peak and each of a plurality of samples within a window of samples;
locating a J-point for each cardiac cycle waveform by identifying, as a location of the J-point in the cardiac cycle waveform, a sample from among the plurality of samples having the shortest Euclidian distance to the R-peak; and
determining a physical state of the patient based on the J-point located in at least one cardiac cycle waveform.

US Pat. No. 10,188,301

MEDICAL PROBE AND METHOD OF USING SAME

St. Jude Medical, Cardiol...

1. A system for monitoring luminal esophageal temperatures in a patient, comprising:a probe adapted to be inserted into an esophagus of the patient, the probe extending between a proximal end and a distal end;
a plurality of electrodes and a plurality of temperature sensors extending along a length of the probe to enable continuous monitoring of temperatures in an area of the esophagus subject to formation of atrial-esophageal fistulas during a cardiac ablation;
a controller having software executing thereon;
a temperature sensor interface coupled to the probe remote from the distal end of the probe, the temperature sensor interface being in communication with the plurality of temperature sensors;
an electrode interface coupled to the probe remote from the distal end of the probe, the electrode interface being in communication with the plurality of electrodes;
wherein the electrode interface is connected to the controller and the controller is adapted to receive signals from the electrode interface;
wherein the temperature sensor interface is connected to the controller and the controller is adapted to receive signals from the temperature sensor interface;
a video monitor in communication with the controller;
wherein the controller is configured to display on the monitor an anatomic map of the esophagus based at least in part on the signals received from the electrode interface;
wherein the controller is configured to display on the monitor a thermal map of the esophagus based at least in part on the signals received from the temperature sensor interface; and
wherein the thermal map is overlaid on the anatomic map.

US Pat. No. 10,188,292

DEVICE FOR SCREENING CONVERGENCE INSUFFICIENCY AND RELATED COMPUTER IMPLEMENTED METHODS

1. A device for screening a person for convergence insufficiency (CI) with a viewer, the device comprising:a display adjacent the viewer; and
a processor and associated memory cooperating with said display and configured to
record movement of a first eye,
record movement of a second eye,
display on said display a first visual stimulus and a second visual stimulus,
cause, in alternating fashion, convergent movement and divergent movement in the first visual stimulus and the second visual stimulus along a visual stimulus path,
record dynamic movement of the first eye along the visual stimulus path,
record dynamic movement of the second eye along the visual stimulus path,
determine respective centroid positions of the second eye and the first eye during the convergent and divergent movement of the first visual stimulus and the second visual stimulus based on the recorded dynamic movements of the first eye and the second eye,
calculate from the respective centroid positions a plurality of interpupillary distances (IPDs) over time, and from the plurality of the IPDs, generate dynamic IPDs over time, and
compare the dynamic IPDs with the visual stimulus path to serve as an indicator for whether the person has CI.

US Pat. No. 10,188,291

DEVICE FOR SCREENING CONVERGENCE INSUFFICIENCY AND RELATED METHODS

1. A device for screening a person for convergence insufficiency (CI), the device comprising:a binocular viewer comprising a first eyepiece to receive a first eye of the person, a second eyepiece to receive a second eye of the person, a first image sensor adjacent said first eyepiece, and a second image sensor adjacent said second eyepiece;
a display adjacent said binocular viewer; and
a processor and associated memory cooperating with said display and configured to
record, with said first image sensor, movement of the first eye,
record, with said second image sensor, movement of the second eye,
display on said display a first visual stimulus and a second visual stimulus,
cause, in alternating fashion, convergent movement and divergent movement in the first visual stimulus and the second visual stimulus along a visual stimulus path,
record with the first image sensor, dynamic movement of the first eye along the visual stimulus path,
record with the second image sensor, dynamic movement of the second eye along the visual stimulus path,
determine respective centroid positions of the second eye and the first eye during the convergent and divergent movement of the first visual stimulus and the second visual stimulus based on the recorded dynamic movements of the first eye and the second eye, and
calculate from the respective centroid positions a plurality of interpupillary distances (IPDs) over time, and from the plurality of the IPDs, generate dynamic IPDs over time, and
compare the dynamic IPDs with the visual stimulus path to serve as an indicator for whether the person has CI.

US Pat. No. 10,188,289

SYSTEMS AND METHODS FOR LENSED AND LENSLESS OPTICAL SENSING

Rambus Inc., Sunnyvale, ...

1. A system for tracking movement of an eye, the system comprising:an array of photoelements;
a grating to collect light reflected from the eye, the grating having a point spread function that focuses light from a point-source to a pattern spatially distributed across non-adjacent ones of the photoelements; and
a processor coupled to the array of photoelements to compute a location of the point source from features of the pattern.

US Pat. No. 10,188,287

OPTICAL MEASUREMENT SYSTEMS AND METHODS WITH CUSTOM CHROMATIC ABERRATION ADJUSTMENTS

AMO WaveFront Sciences, L...

1. A method for measuring a characteristic of a subject's eye which includes a cornea and a lens, the method comprising:using a probe beam having an infrared wavelength in the infrared spectrum to measure a refraction of the subject's eye at the infrared wavelength;
capturing at least two different Purkinje images at two different corresponding wavelengths from at least one surface of the lens of the subject's eye;
determining from the at least two different Purkinje images a value for at least one parameter of the subject's eye;
using the value of the at least one parameter to determine a customized chromatic adjustment factor for the subject's eye; and
correcting the measured refraction of the subject's eye at the infrared wavelength with the customized chromatic adjustment factor to determine a refraction of the subject's eye at a visible wavelength in the visible spectrum.

US Pat. No. 10,188,285

IMAGING APPARATUS

Canon Kabushiki Kaisha, ...

1. An imaging apparatus comprising:a light-source unit configured to emit light while sweeping a frequency of the light;
an interference unit configured to separate the light emitted from the light-source unit into illuminating light to be applied to a fundus and reference light, and to generate interfering light formed of reflected light, which is light applied to the fundus and reflected by the fundus, and the reference light;
a scanning unit configured to scan the fundus with the illuminating light;
a detecting unit configured to detect the interfering light; and
an information-acquiring unit configured to acquire information on the fundus from the interfering light,
wherein the scanning unit is configured such that an angle of linear scanning of the fundus with the illuminating light is 68 degrees or greater in the air,
wherein the light-source unit in hides a surface-emitting laser, the surface-emitting laser including a first reflector, a second reflector, and an active layer provided between the first reflector and the second reflector,
wherein, when at least one of the first reflector and the second reflector is driven, a distance between the first reflector and the second reflector changes and the frequency of the light emitted changes,
wherein a coherence length of the surface-emitting laser during the sweeping of the frequency of the light is 23 mm or longer, and
wherein a range of a depth of a tomographic image of the fundus to be obtained using the information on the fundus is 3.2 mm or more.

US Pat. No. 10,188,284

TEAR-FILM SENSING EYE-MOUNTABLE DEVICE

Verily Life Sciences LLC,...

1. An eye-mountable device, comprising:an enclosure shaped to be removably mounted over a cornea of an eye of a user;
a tear-film sensor system, including at least a first pair and a second pair of tear-film-sensitive sensors to measure an impedance across the eye-mountable device associated with a tear-film of the eye when the eye-mountable device is mounted on the eye of the user, wherein the tear-film sensor system is configured to alternately output a first and a second alternating current (AC) signal to measure the impedance, wherein the first AC signal is between the first pair of the tear-film-sensitive sensors disposed on opposite sides of the eye-mountable device from one another, and wherein the second AC signal is between the second pair of the tear-film-sensitive sensors disposed on opposite sides of the eye-mountable device from one another; and
a controller disposed within the enclosure and coupled to the tear-film sensor system, wherein the controller includes instructions that when executed by the controller causes the eye-mountable device to perform operations including:
monitoring the impedance across the eye-mountable device based, at least in part, on the alternately outputted first and second AC signals, wherein the impedance is influenced by the tear-film of the eye and an orientation of the eye; and
determining a gaze direction of the eye based, at least in part, on the impedance and, in response to changes in the impedance, actively controlling circuitry disposed in the eye-mountable device.

US Pat. No. 10,188,283

TRIAL FRAME

OCULUS OPTIKGERAETE GMBH,...

1. A trial frame for determining the subjective refraction of a subject, comprising:first and second lens holder devices for receiving insert lenses;
a bridge, which connects the first and second lens holder devices in such a manner that their distance relative to each other is adjustable;
a nose rest device having a pivotable and height-adjustable nose rest;
first and second temples, which are adjustable in a length and a height dimension, the trial frame comprising first and second polarization filter devices, each of the first and second polarization filter devices having a circular or a linear polarization filter,and a pivot for pivoting the circular or linear polarization filter in and out in front of the corresponding one of the first and second lens holder devices and a rotating device for rotating the polarization filter in front of the corresponding one of the first and second lens holder devices, the polarization filter devices each being removably attachable to the corresponding one of the first and second lens holder devices through a locking connection; and a one-piece spring clamp formed on an attachment end of a holder of at least one of the polarization filter devices, said spring clamp engaging behind a crosspiece molded to each of the corresponding one of the first and second lens holder devices, and an actuating lever molded to the spring clamp and configured to selectively open the spring clamp.

US Pat. No. 10,188,281

PROGRAMMABLE MULTISPECTRAL ILLUMINATION SYSTEM FOR SURGERY AND VISUALIZATION OF LIGHT-SENSITIVE TISSUES

The Johns Hopkins Univers...

1. An observation system for viewing light-sensitive tissue, comprising:an illumination system;
an imaging system arranged to be in an optical path of light from said light-sensitive tissue upon being illuminated by said illumination system, said imaging system comprising an optical detector and a data processing system; and
an image display system in communication with said imaging system to display an image of a portion of said light-sensitive tissue,
wherein said illumination system comprises a light source and a light source controller constructed and arranged to control at least one of a spectral composition and intensity of light that illuminates said light-sensitive tissue;
wherein said light source controller causes said light source to illuminate said light-sensitive tissue with light having a reduced amount of light at wavelengths that are harmful to said light-sensitive tissue relative to a white light spectrum,
wherein said imaging system is configured to image at least a portion of said light-sensitive tissue upon being illuminated by said illumination system by applying a color boost model to compensate for said reduced amount of light at wavelengths that are harmful to said light-sensitive tissue.

US Pat. No. 10,188,280

TISSUE SEPARATION, EQUALIZATION, ERADICATION AND REGENERATION DEVICES AND METHODS

1. A tissue separation and equalization device, comprising:a generally elongated tissue insertion member having an elongated cannula wall including a distal cannula end and a cannula interior, the distal cannula end closing the cannula interior;
at least one tissue separating member opening in the tissue insertion member, the at least one tissue separating member opening disposed in fluid communication with the cannula interior;
at least one elongated tissue separating member having at least one flexible or bendable expansion segment, respectively, extending longitudinally within the cannula interior of the tissue insertion member generally adjacent to the at least one tissue separating member opening, respectively, the at least one tissue separating member opening and the cannula interior forming a continuous flow path; and
a driving mechanism engaging the at least one tissue separating member and operable to displace the at least one tissue separating member within the tissue insertion member and expand or buckle the at least one expansion segment outwardly from the tissue insertion member through the at least one tissue separating member opening, respectively, an entire volume of the cannula interior disposed in fluid communication with an exterior of the tissue insertion member through the at least one tissue separating member opening.

US Pat. No. 10,188,278

USING AN INTRAORAL MIRROR WITH AN INTEGRATED CAMERA TO RECORD DENTAL STATUS, AND APPLICATIONS THEREOF

DENTAL SMARTMIRROR, INC.,...

16. A system for capturing an image representing a patient's dental status, comprising:a processor;
a patient status database that stores historical patient status information including historical panoramic images of a patient's mouth; and
a server, executed on the processor, that receives (i) a plurality of photographs of an interior of the patient's mouth, and (ii) associated position information for the respective photographs, wherein the plurality of photographs are collected from an image sensor affixed to a dental mirror, wherein the position information is collected relative to a base station capable of docking to the dental mirror, wherein the position information is determined using an accelerometer or gyroscope or both affixed to the dental mirror, wherein the accelerometer or gyroscope or both is calibrated with the dental mirror while docked to the base station, and wherein each one of the plurality of photographs overlap at least in part with another one of the plurality of photographs, the server comprising:
a panorama stitcher module that (i) determines features in the overlapping portions that match between multiple photographs, (ii) based on associated position information for the respective photographs and the matching features, aligns the plurality of photographs to represent a series of adjacent teeth, and (iii) stitches the plurality of photographs of the interior of the patient's mouth into a panoramic image representing a state of at least a portion of the patient's mouth.

US Pat. No. 10,188,276

CLEANING AUXILIARY TOOL

OLYMPUS CORPORATION, Tok...

1. A cleaning auxiliary tool to be inserted into a bottomed cylinder having a bottomed cylindrical shape with one end opened and other end closed, the bottomed cylinder having a first opening through which a fluid from a first conduit is introduced, the first conduit being inserted through an endoscope, a second opening through which the fluid is led out into the first conduit, a third opening through which the fluid from a second conduit is introduced, the second conduit running in parallel with the first conduit in the endoscope, and a fourth opening through which the fluid is led out into the second conduit, the cleaning auxiliary tool comprising:a lid portion that closes an opening of the bottomed cylinder;
a shaft portion having a first end portion connected to the lid portion and a second end portion extending into the bottomed cylinder;
a first plate member fixed to the shaft portion, the first plate member having a first outer diameter smaller than an inner diameter of the bottomed cylinder;
a second plate member fixed to the shaft portion and arranged closer to the first conduit than the first plate member, the second plate member having a second outer diameter smaller than the inner diameter of the bottomed cylinder; and
a partition portion provided between the first plate member and the second plate member and positioned between the first opening and the third opening and between the second opening and the fourth opening, that partitions a side of the first conduit and a side of the second conduit in a state of being in close contact with an inner wall of the bottomed cylinder, moves toward the second end portion of the shaft portion by receiving an internal pressure on the side of the first conduit when the internal pressure on the side of the first conduit becomes higher than an internal pressure on the side of the second conduit, and moves toward the first end portion of the shaft portion by receiving the internal pressure on the side of the second conduit when the internal pressure on the side of the second conduit becomes higher than the internal pressure on the side of the first conduit, the partition portion,
when moving toward the second end portion and when moving toward the first end portion, contacts the inner wall with an outer circumferential portion of the partition portion, and axially moves along the shaft portion a distance sufficient to allow the fluid to contact the entire inner wall disposed between the first plate member and the second plate member.

US Pat. No. 10,188,274

CAPSULE ENDOSCOPE SYSTEM, CAPSULE ENDOSCOPE, RECEPTION APPARATUS, LIGHT EMISSION CONTROL METHOD OF CAPSULE ENDOSCOPE, AND COMPUTER READABLE STORAGE DEVICE

OLYMPUS CORPORATION, Tok...

1. A capsule endoscope system comprising:a capsule endoscope having:
a first image sensor configured to capture an image in a first direction in a first imaging area, and output first image data;
a first light source configured to perform light emission in the first direction;
a second image sensor configured to capture an image in a second direction different from the first direction in a second imaging area that does not overlap the first imaging area at a second time different from a first time at which the first image sensor performs imaging, and output second image data;
a second light source configured to perform light emission in the second direction;
an imaging controller configured to control the imaging by the first image sensor and the second image sensor;
the imaging controller further being configured to control light emissions by the first light source and the second light source; and
a first wireless communication interface configured to transmit the first image data and the second image data; and
a receiver having a second wireless communication interface configured to receive the first image data and the second image data,
wherein the capsule endoscope or the reception apparatus is configured to detect a lesioned part from the first image data or the second image data; and
a controller configured to instruct the imaging controller to execute a first light emission operation in which only a light source configured to perform the light emission in the imaging direction of an image sensor that is performing imaging performs the light emission when no lesioned part is detected and instruct the imaging controller to execute a second light emission operation in which a light source configured to perform the light emission in a second imaging direction of an image sensor different from an image sensor that is imaging the lesioned part performs the light emission in synchronization with the light emission by a light source configured to perform the light emission in a first imaging direction of the image sensor that is imaging the lesioned part when the lesioned part is detected.

US Pat. No. 10,188,271

ASSIST DEVICE AND ENDOSCOPE SYSTEM

OLYMPUS CORPORATION, Tok...

1. An assist device which is applied to a treatment instrument, the treatment instrument including an insertion body to be inserted through a channel of an insertion section of an endoscope, the assist device being configured to assist movement of the insertion body relative to the channel, the assist device comprising:a flexible tube including a passage into which the insertion body of the treatment instrument is inserted, the flexible tube including one end and an other end;
a connector configured to connect the one end of the flexible tube to the channel such that the passage communicates with the channel;
a first retainer configured to attach a side of the other end of the flexible tube to an outer circumference of the insertion section of the endoscope or to an outer circumference of an operation section connected to the insertion section;
a second retainer being movable relative to the first retainer and configured to hold the insertion body of the treatment instrument; and
a connecting member connecting the first retainer and the second retainer to each other,
wherein the second retainer is detachably attached to the insertion body of the treatment instrument in a direction different from a longitudinal direction of the insertion body.

US Pat. No. 10,188,270

STENT DELIVERY SYSTEM

OLYMPUS CORPORATION, Tok...

1. A stent delivery system comprising:a guide catheter formed in a tube shape;
a stent formed in a tube shape and into which the guide catheter is inserted; and
a pusher catheter formed in a tube shape and into which the guide catheter is inserted, the pusher catheter being disposed proximally relative to the stent,
wherein the pusher catheter includes:
an intermediate part having a distal end part and a proximal end part; and
a diameter expansion-suppressing part joined to the distal end part of the intermediate part, the diameter expansion-suppressing part having a bending stiffness greater than a bending stiffness of the intermediate part and having an inner diameter the same as an inner diameter of the stent;
an outer diameter of the diameter expansion-suppressing part is the same as an outer diameter of the intermediate part, the diameter expansion-suppressing part and the intermediate part comprise a mixture of at least a first material and a second material respectively, a mixing ratio of an amount of the first material and an amount of the second material of the diameter expansion-suppressing part being different from a mixing ratio of an amount of the first material and an amount of the second material of the intermediate part, and
wherein, when the stent is pushed toward a distal end side by pushing the intermediate part of the pusher catheter toward the distal end side and causing a distal end part of the diameter expansion-suppressing part to come into contact with a proximal end part of the stent, the diameter expansion-suppressing part prevents an inner diameter of the distal end part of the pusher catheter from expanding.

US Pat. No. 10,188,264

DISHWASHER COMPRISING A SORPTION DRYING DEVICE

1. A dishwasher, comprising:a washing container;
an air-guiding channel to generate an air flow;
a sorption drying system to dry items to be washed, wherein the sorption drying system has a sorption container with reversibly dehydratable sorption material, the sorption container connected to the washing container by the air-guiding channel; and
a heater disposed in the sorption container and arranged upstream of the reversibly dehydratable sorption material for desorption of the reversibly dehydratable sorption material;
wherein the air-guiding channel includes an inlet connecting piece connected to the sorption container and which diverts incoming air flow from an inflow direction by between 45° to 135° into a through-flow direction through the heater and the reversibly dehydratable sorption material,
wherein the through-flow direction through the heater and through the reversibly dehydratable sorption material is the same direction, such that the through-flow direction runs from a bottom portion to a top portion of the sorption container, and
wherein the sorption container includes a through-flow cross-sectional area for the reversibly dehydratable sorption material of substantially between 80 cm2 and 800 cm2.

US Pat. No. 10,188,253

EXTRACTION CLEANER WITH QUICK EMPTY TANK

BISSELL Homecare, Inc., ...

1. An extraction cleaner, comprisinga housing that comprises an upright assembly having a handle where the upright assembly is pivotally connected to a base assembly for directing the base assembly across a surface to be cleaned;
a suction nozzle provided on the housing;
a suction source provided on the housing and in fluid communication with the suction nozzle for generating a working airstream; and
a recovery tank for separating and collecting fluid and debris from the working airstream for later disposal, wherein the recovery tank is removably mounted on the housing and comprises:
a recovery container defining a recovery chamber and comprising a drain opening provided on a lower portion of the recovery container;
a valve fluidly connected to the drain opening for movement between a closed position for sealing the recovery chamber and an open position for draining fluid from the recovery chamber; and
an actuator for selectively opening the valve, wherein at least a portion of the actuator is provided on an upper portion of the recovery container.

US Pat. No. 10,188,251

SURFACE MAINTENANCE VEHICLE WITH AN INTEGRATED WATER TRAP FOR TRAPPING RESIDUAL WASTE

Tennant Company, Minneap...

1. A waste recovery system for a floor surface maintenance machine comprising:a squeegee assembly having
a squeegee frame having a top edge, and
a first squeegee operable to engage a floor surface and connected to the squeegee frame; and
a reservoir operatively connected to the squeegee assembly, the reservoir comprising an inlet passage, an outlet passage and a fluid trap portion in fluid communication with the inlet passage and outlet passage, the fluid trap portion having a bottom wall and side walls, the fluid trap portion being adapted to retain backflow waste within the side walls and the bottom wall,
the bottom wall of the fluid trap portion being positioned below the top edge of the squeegee frame, such that backflow waste trapped above the fluid trap portion pools within a space formed by the bottom wall and the side walls of the fluid trap portion and is prevented from draining to the floor surface.

US Pat. No. 10,188,250

FLOOR CLEANING TOOL HAVING A MECHANICALLY OPERATED PUMP

1. A portable, human-powered floor cleaning device comprising:a chassis comprising a clean fluid storage tank and a spent fluid collection tank;
a plurality of wheels for supporting and moving the device;
a mechanically-driven pump housed within the chassis having an inlet and an outlet, the pump operably interconnected to a drive wheel;
the drive wheel provided substantially proximal to a midpoint of the chassis and comprising an eccentric wheel hub interconnected to a drive shaft such that a rotational movement of the drive wheel results in a reciprocating movement of the drive shaft and actuation of the pump;
a deck assembly attached to the chassis comprising a fluid pick-up orifice and at least one squeegee, the fluid pick-up orifice being interconnected to the pump by a conduit for transmitting the spent fluid from the fluid pick-up orifice to the pump; and
a scrubber pad attached to the bottom side of the deck assembly, the scrubber pad having a leading front edge which helps trap debris and presses tight against the floor surface and distributes the clean fluid over the floor surface and loosens soil from the floor surface, wherein the scrubber pad further comprises a curved edge that matches a curvature of the at least one squeegee to create a snug fit of the scrubber pad with the bottom side of the deck assembly.

US Pat. No. 10,188,248

VACUUM CLEANER FILTER BAG

Eurofilters Holding N.V.,...

16. A method for manufacturing a vacuum cleaner filter bag, the vacuum cleaner bag being formed as a flat bag and comprising a bag wall made of filter material that has a through passage through which the air that is to be cleaned can flow into the vacuum cleaner filter bag, the bag wall consisting of an at least partially pleated nonwoven material, and a first and a second filter material layer that are connected to each other by a peripheral weld seam,wherein the first or the second filter material layer consists of the at least partially pleated nonwoven material, the method comprising:
pleating of at least a portion of a nonwoven web;
assembling of the vacuum cleaner filter bag using the at least partially pleated nonwoven web; and
connecting folds of the at least partially pleated nonwoven material to one another at least partially by a fixing device;
wherein the fixing device is configured to hold the folds of the at least partially pleated nonwoven material at a predetermined distance from one another when the vacuum cleaner filter bag is unfolded during operation of the vacuum cleaner filter bag; and
wherein the fixing device is arranged on a first side of the at least partially pleated nonwoven material facing towards an interior of the vacuum cleaner filter bag and a second side of the at least partially pleated nonwoven material on an exterior of the vacuum cleaner filter bag is free from any fixing device.

US Pat. No. 10,188,245

TOILET

1. A toilet comprising:a seat having an opening therein;
a seat back connected to the seat;
a first arm having a first pressure sensor and a second arm having a second pressure sensor, the first arm and the second arm being spaced apart and positioned above the seat;
an actuator that moves the seat to a position wherein the seat inclines upwardly from a rear portion of the seat to a front portion of the seat;
wherein, in use, the first pressure sensor senses pressure on the first arm and the second pressure sensor senses pressure on the second arm, and upon the first pressure sensor or the second pressure sensor sensing pressure, a signal is transmitted to the actuator, whereupon the actuator moves the seat to incline upwardly from the rear portion of the seat to the front portion of the seat.

US Pat. No. 10,188,240

POT LID STORAGE HOLDER

1. A pot lid storage holder, configured for storing a pot lid having a handle with a necked-down portion disposed between the pot lid and a relatively enlarged portion of the handle, the holder comprising first and second gripping elements spaced apart from one another, each gripping element having a first respective substantially straight portion fixedly attached to and projecting from a mounting member, a respective return portion connected to said first respective substantially straight portion, and a second respective substantially straight portion connected to said respective return portion, projecting back toward but short of said mounting member and having an end that is free to move with respect to said mounting member, the second respective substantially straight portions of the first and second gripping elements being substantially parallel to one another in an undeflected state and configured to receive the necked-down portion of the handle, through an opening there between, in a downstream direction of insertion of the pot lid into the pot lid storage holder pointing toward the mounting member so as to deflect at least one of said first and second substantially straight portions which thereby exerts a compressive spring force on the necked-down portion that decreases with increasing depth of insertion of the necked down portion of the handle in the downstream direction.

US Pat. No. 10,188,238

BEVERAGE PRODUCTION MACHINES AND METHODS WITH TAMPING ASSEMBLY

Starbucks Corporation, S...

1. A machine for preparing single-servings of a beverage, the machine comprising:a housing;
a lid assembly on the top of the housing configured to move between an open configuration to allow insertion of a cartridge containing a beverage precursor and a closed configuration in which the beverage is prepared from the beverage precursor;
a basket assembly comprising a chamber configured to receive the cartridge containing the beverage precursor; and
a lid cam connected to the lid assembly, the lid cam having an upper wall portion, a sidewall, and a cam path disposed along the sidewall, wherein the lid cam translates axially relative to the lid assembly, the lid cam being suspended by at least one lid spring, and the cam path comprises a lower cam path and an upper cam path;
a collar having one or more cam teeth configured to engage the cam path,
a tamping surface on the bottom of the lid assembly and connected to the lid cam, wherein when the lid assembly is in the closed configuration, the tamping surface is configured to move between an untamped state in which the tamping surface does not compress the beverage precursor and a tamped state in which the tamping surface compresses the beverage precursor;
wherein the collar is configured to movably engage the lid cam and rotate about a central axis extending longitudinally through the basket assembly, wherein rotation of the collar about the central axis and with respect to the lid cam axially moves the tamping surface so that the tamping surface is closer to the basket assembly in the tamped state than in the untamped state;
wherein in the untamped state, the one or more cam teeth engage the lower cam path, and wherein in the tamped state, the one or more cam teeth engage the upper cam path.

US Pat. No. 10,188,237

MULTISIZE CAPSULE HANDLING WITH SERIAL ACTUATION

Nestec S.A., Vevey (CH)

1. A machine comprising a frame and a capsule handling device configured to handle an capsule and mounted in and/or on the frame, the capsule handling device comprising:a first part;
a second part that is movable relative to the frame from a transfer position for inserting and/or removing the capsule to an extraction position for extracting the capsule and vice versa, the second part comprising:
a capsule receptacle defining a cavity for receiving the capsule and for forming in the extraction position an extraction chamber with the first part, and
a first portion and a second portion that are relatively movable between a first relative position and a second relative position to change at least one dimension of the cavity and of the extraction chamber;
an actuator connected to the second part for driving the second part between the transfer position and the extraction position, the actuator is connected to the first portion and/or the second portion of the second part to relatively move the first portion and the second portion between a first relative position and a second relative position; and
a mechanical transmission connecting the actuator to the second part and to the first portion and the second portion of the second part for driving:
the second part between the transfer position and the extraction position; and
the first portion and/or the second portion of the second part to relatively move the first portion and the second portion between the first relative position and the second relative position.

US Pat. No. 10,188,236

MACHINE FOR DISPENSING BEVERAGES

IDES DEVELOPMENT COMPANY ...

1. A guiding device of a capsule, for use in a machine for dispensing beverages extracted from capsules, in particular coffee, tea, herbal teas and the like, which machine comprises:a capsule-holder which defines an infusion chamber;
an infusion head configured to cooperate with the capsule-holder for an extraction of a beverage, said infusion head is configured with an engagement tab element;
a lever to provide a relative movement of the capsule with respect to the capsule-holder, said lever being configured to provide a relative translational motion of the capsule with respect to the infusion chamber in a direction of infusion; and
a frame having the capsule-holder and the infusion head disposed therein;
the guiding device comprises:
a retainer of the capsule during said relative translational motion, the retainer comprising at least a first retaining guide element and a second retaining guide element both for retaining a peripheral projecting edge of the capsule,
wherein said first retaining guide element is configured with a first channel so as to retain the capsule during a relative motion that carries the capsule to be infused to enter within the infusion chamber, said first retaining guide element and said second retaining guide element being movable within the frame of the machine,
and said second retaining guide element adjoins said first retaining guide element, and said second retaining guide element is configured with a second channel in such a way as to retain the capsule, once used, during a relative movement of extraction of the capsule from the infusion chamber and to allow capsule ejection by gravity from the machine; and
a mechanical controller, configured to determine that the relative translational motion between the capsule and the infusion chamber is carried out in a coordinated manner with a relative position between the capsule-holder and the infusion head, wherein said mechanical controller in turn comprises:
one or more arms extending from said first retaining guide element, each of said arms being configured to be slidingly coupled within the frame of the machine;
an engagement profile disposed on said one or more arms, which engagement profile is configured to couple with a corresponding profile within the frame of the machine, said coupling causing, in use, a divarication of the device relative to the infusion head; and
an engagement projecting element disposed on said one or more arms, which engagement projecting element is configured to couple with said engagement tab element of the machine so as to allow a selective dragging in translation of the device during a return stroke after infusion.

US Pat. No. 10,188,235

FILTER CUP

1. A filter cup comprising:an inner cup having a top, a filter bottom surface, and an intermediate portion extending therebetween, the filter bottom surface defining a conical surface contour, a plug-like member extending from the filter bottom surface, and at least two flanges set on two corresponding edges at the top of the inner cup;
an outer cup receiving the inner cup therein and having an upper part, a bottom surface, and a side wall portion extending therebetween, a discharge hole formed in the bottom surface aligned with the plug-like member of the inner cup for being plugged by the plug-like member to prevent leakage and
two rotating members pivotally connected to the upper part of the outer cup and disposed respectively underneath the two flanges of the inner cup received in the outer cup; a leaning portion radially extended and projecting from an axial part of each rotating member adjacent the side wall portion of the outer cup; and
a grip having two ends connected to the two rotating members respectively;
wherein the rotating members are driven to move the leaning portions thereof to push the flanges of the inner cup upward when the grip is displaced relative to the outer cup; a gap being thereby formed between the plug-like member and the discharge hole; allowing liquid in the inner cup to flow out from the discharge hole through the gap.

US Pat. No. 10,188,233

ARTICULATING STAND FOR BROOMS AND SIMILARLY HANDLED IMPLEMENTS

1. An articulating stand for brooms and similarly handled implements, the stand comprising:a first clipping portion and a second dipping portion;
the first clipping portion and the second clipping portion configured to hold an elongated handle under a tension sufficient to prevent the handle from sliding therethrough;
the first clipping portion disposed at an angle relative to the second dipping portion, such that the first clipping portion is configured to release the handle when the second clipping portion engages the handle and vice versa;
a panel for engaging a standing surface on which the articulating stand and an implement rests;
the panel having a wide bottom portion with opposing ends, the opposing ends and handle thereby conferring tripod support to the stand and the implement; and
wherein the panel is in substantially linear arrangement with the second clipping portion, such that the panel is adjacent the handle when the second clipping portion is in an engaging position on the handle, and the panel is not adjacent the handle when the first clipping portion is in an engaging position on the handle.

US Pat. No. 10,188,231

FLEXIBLE MEMBRANE DRINKING CUP LID

1. A lid device for a beverage cup, said device comprising:an annular structure comprising an inner flexible material surrounded by an outer ring of substantially rigid material, said outer ring configured to reversibly attach to a rim of a beverage cup;
said inner flexible material having a central structure, said central structure comprising an opening with an axis that, in the absence of applied force, is substantially perpendicular to a top surface of said central structure;
said central structure configured to allow a drinking straw to pass through said central structure and into an interior of said beverage cup, said drinking straw comprising a radius;
said opening further comprising an opening radius between 1 and 2 times said radius of said drinking straw;
said inner flexible material and said central structure further configured to allow a human user of said straw, using a hand force of 5 Newtons or less on said drinking straw, to displace any of:
a: an orientation of said axis by at least +/?20 degrees from a no force resting state;
b: a location of said opening by at least 2× said radius of said drinking straw from a no force resting state;wherein said inner flexible materials, said outer ring of substantially rigid material, and said central structure are securely attached to each other so as to prevent rotation of any of said inner flexible material, substantially rigid material, or central structure relative to each other.

US Pat. No. 10,188,230

WIRELESS DRINK CONTAINER FOR MONITORING HYDRATION

1. A container assembly comprising:a container defining a cavity to hold a liquid;
a liquid level sensor, disposed in the cavity, to measure a level of the liquid in the cavity;
a processor, operably coupled to the liquid level sensor, to poll the liquid level sensor for a measurement of the level of the liquid in the cavity and to estimate a change in the level of the liquid in the cavity based on the measurement of the level of the liquid in the cavity;
a visual indicator, operably coupled to the processor and disposed within the cavity, to provide a visual indication prompting a user to drink from the container; and
an antenna, operably coupled to the processor, to transmit an indication of the change in the level of the liquid in the cavity to a wireless device.

US Pat. No. 10,188,229

HEATED OR COOLED DISHWARE AND DRINKWARE

Ember Technologies, Inc.,...

1. A portable cooler container with active temperature control, comprising:a container body having an outer wall, an inner wall spaced from the outer wall to define a gap therebetween, and a chamber configured to receive and hold one or more volumes of perishable liquid, the chamber defined by a base and the inner peripheral wall of the container body, the gap being under vacuum to thereby insulate the chamber relative to the outer wall; and
a temperature control system in the container body, comprising
one or more Peltier elements configured to actively heat or cool at least a portion of the chamber,
one or more power storage elements,
a microcontroller configured to control an operation of the one or more Peltier elements to heat or cool at least a portion of the chamber to a predetermined temperature or temperature range, the microcontroller further configured to wirelessly communicate with a cloud-based data storage system; and
one or more sensors configured to sense one or more parameters of the chamber or temperature control system and communicate the sensed information to the microcontroller, at least one of the one or more sensors being a temperature sensor configured to sense a temperature in the chamber and to communicate the sensed temperature to the microcontroller, the microcontroller operable to communicate sensed temperature data to the cloud-based data storage system for storage and from which the data is accessible via a dashboard interface on an electronic device.

US Pat. No. 10,188,225

ADJUSTABLE SCANNER MOUNTING ASSEMBLY AND METHOD

Mettler-Toledo, LLC, Col...

1. An adjustable scanner mounting assembly, comprising:a pair of first mounting rails forming a part of opposite walls of a scanner/scale device housing or adapted for attachment to opposite walls of a scanner/scale device housing;
a pair of second mounting rails adapted to cooperatively support a scanner and extending transversely between the first mounting rails and slidably connected thereto, a scanner retention wall extending upwardly from and along the length of each second mounting rail; and
at least one scanner locating mechanism movably affixed to each of the second mounting rails so as to be slidable along the length thereof;
wherein, positional adjustment of a scanner along a first axis is accomplishable by sliding the second mounting rails along the length of the first mounting rails; and
wherein, positional adjustment of a scanner along a second axis is accomplishable by sliding the scanner locating mechanisms along the length of the second mounting rails.

US Pat. No. 10,188,224

REFRIGERATED CASE WITH A SELF-CONTAINED CONDENSATE REMOVAL SYSTEM AND LEAK DETECTION

Killion Industries, Inc.,...

1. A refrigerated case, comprising:a refrigerated space;
an air inlet;
an air outlet;
a condensate collection tray configured to collect condensate from the refrigerated space;
a refrigeration system having a controller and configured to remove heat from the refrigerated space and remove the condensate from the condensate collection tray collected from the refrigerated space;
a condensate level detector located within the condensate collection tray and configured to measure a level of the condensate in the condensate collection tray and to generate a condensate level signal in response to a presence of the condensate at a predetermined condensate level in the condensate collection tray;
a means to remove the condensate from the condensate collection tray in communication with the condensate level detector, wherein the means to remove the condensate from the condensate collection tray is configured to remove the condensate upon detection of the condensate level signal;
a leak detector located at a high point of the condensate collection tray and configured to generate a high point signal in response to the presence of condensate at the high point of the condensate collection tray;
a condensate sensor located at a low point of the refrigerated case outside of said condensate collection tray and configured to generate a condensate detected signal in response to the presence of the condensate;
wherein the condensate level signal from the condensate level detector causes the means to remove the condensate from the condensate collection tray to turn on until the condensate level signal is no longer detected;
wherein the high point signal from the leak detector causes the refrigeration system to automatically shut down and turns on the means to remove the condensate from the condensate collection tray until the high point signal is no longer detected; and
wherein the condensate detected signal from the condensate sensor causes the refrigeration system to automatically shut down until the condensate detected signal is no longer detected.