US Pat. No. 10,189,021

MICROFLUIDIC CHIP, MANUFACTURING METHOD THEREFOR AND ANALYSIS DEVICE USING SAME

NANOBIOSYS INC., Seoul (...

1. A microfluidic chip comprising:a substrate comprising, an inflow part penetrating the substrate in a thickness direction,
an outflow part penetrating the substrate in the thickness direction, and
a fluid channel defined to connect the inflow part and the outflow part and extending in a first direction within the substrate, wherein the thickness direction and the first direction are different from one another; and
a film attached to the substrate and covering at least a portion of at least one of the inflow part, the outflow part, and the fluid channel, the film configured to protect at least one of the inflow part, the outflow part and the fluid channel from the outside;
wherein the film includes a first film attached to a top surface of the substrate and a second film attached to a bottom surface of the substrate;
wherein the fluid channel includes an upper fluid channel formed on a top surface of the substrate; a lower fluid channel formed on a bottom surface of the substrate; and a third fluid channel connecting the upper fluid channel and the lower fluid channel,
wherein a thickness of the at least one film is smaller than a thickness of the substrate.

US Pat. No. 10,189,020

SPECIMEN COLLECTION APPARATUS

Alpha Tec Systems, Inc., ...

1. A sample collection apparatus, comprising:a container having an interior portion configured to contain a sample and an opening to the interior portion, the opening for receiving the sample;
a funnel configured to be secured to the opening of the container, the funnel having a mouth portion and a neck portion depending from the mouth, the neck portion configured to be inserted into the opening of the container; and
a closure assembly including:
a first closure structure configured to releasably seal the opening of the container, the first closure structure including a chamber that is in fluid communication with the interior portion of the container when the opening is sealed by the first closure structure,
a chemical reagent contained within the chamber, and
a second closure structure configured to releasably cover the mouth portion of the funnel, wherein the first closure structure is removably attached to the second closure structure.

US Pat. No. 10,189,015

HYDROPROCESSING CATALYST COMPOSITION CONTAINING AN ACETOACETIC ACID COMPOUND, A METHOD OF MAKING SUCH A CATALYST, AND A PROCESS OF USING SUCH CATALYST

SHELL OIL COMPANY, Houst...

1. A catalyst composition comprising: a calcined shaped support material that is impregnated by a single impregnation step with a cobalt or nickel component, a molybdenum component, and a phosphorous component and dried without calcination and incorporated with an acetoacetic acid compound additive, wherein the catalyst composition is non-sulfurized.

US Pat. No. 10,189,011

EXHAUST GAS PURIFYING CATALYST AND METHOD FOR PRODUCING THE SAME

TOYOTA JIDOSHA KABUSHIKI ...

1. A method for producing an exhaust gas purifying catalyst including a porous carrier and a noble metal catalyst supported on the porous carrier, the porous carrier containing particles of an alumina-ceria-zirconia composite oxide including ceria-zirconica composite oxide, the method comprising:preparing the porous carrier having physical property values, after subjected to baking at 900° C. for 5 hours, of a pore diameter of the particles in a range of 2 to 20 nm, a specific surface area of the particles in a range of 75 to 115 m2/g, a crystallite size of the ceria-zirconia composite oxide that is contained in the particles in a range of 4 to 6 nm, and a bulk density of the particles in a range of 0.5 to 0.9 cm3/g; and
bringing a noble metal chemical solution into contact with the porous carrier, the noble metal chemical solution having an aggregate of one of platinum, palladium, or rhodium with a grain size adjusted to less than or equal to 1 nm with use of one of a platinum nitric acid solution, palladium nitric acid solution, or rhodium nitric acid solution, so that the noble metal catalyst is supported on the porous carrier.

US Pat. No. 10,189,010

COMPOSITION BASED ON ZIRCONIUM OXIDE AND ON AT LEAST ONE OXIDE OF A RARE EARTH OTHER THAN CERIUM, HAVING A SPECIFIC POROSITY, PROCESSES FOR PREPARING SAME AND USE THEREOF IN CATALYSIS

Rhodia Operations, Paris...

1. A composition comprising zirconium oxide and at least one oxide of a rare earth other than cerium, in a weight proportion of zirconium oxide of at least 50%, wherein after calcination at a temperature of 900° C. for 4 hours, the composition as measured by mercury intrusion porosimetry in accordance with standard ASTM D 4284-8 exhibits two populations of pores of which respective diameters are centered, for a first population, about a value of between 20 nm and 40 nm and, for a second population, about a value of between 80 nm and 200 nm, and wherein the composition has a specific surface area of at least 25 m2/g after calcination at 1100° C. for 4 hours.

US Pat. No. 10,189,006

INTEGRAL 3D GRAPHENE-CARBON HYBRID FOAM

Nanotek Instruments, Inc....

1. An integral graphene-carbon hybrid foam comprising multiple pores and pore walls, wherein said pore walls comprise single-layer or few-layer graphene sheets selected from the group consisting of graphene fluoride, graphene chloride, graphene bromide, graphene iodide, hydrogenated graphene, nitrogenated graphene, and combinations thereof and containing 0.001% to 25% by weight of non-carbon elements; wherein said few-layer graphene sheets have 2-10 layers of stacked graphene planes having an inter-plane spacing d002 from 0.3354 nm to 0.40 nm as measured by X-ray diffraction; and wherein said single-layer or few-layer graphene sheets are chemically bonded by a carbon material and have a carbon material-to-graphene weight ratio from 1/200 to 1/2.

US Pat. No. 10,189,005

PUMP FOR CORROSIVE FLUIDS

1. A pump for pumping a corrosive fluid, wherein the pump comprises:a sealed internal chamber;
a pumping chamber, wherein the pumping chamber is within the sealed internal chamber;
a pump inlet connected to the pumping chamber;
a pump outlet connected to the pumping chamber;
a rotational pumping element configured for pumping the corrosive fluid from the pump inlet to the pump outlet, wherein the rotational pumping element is within the pumping chamber;
a drive shaft for driving the rotational pumping element, wherein the drive shaft is completely within the sealed internal chamber, wherein the drive shaft is configured for magnetically coupling to an external motor;
a pump housing forming the sealed internal chamber, the pump housing including a containment can for forming a magnetic coupler receptacle within the sealed internal chamber,;
a cylindrical internal magnetic coupler located within a magnet receptacle, the cylindrical internal magnetic coupler being connected to the drive shaft; and
an external magnetic coupler located outside of the sealed internal chamber, the external magnetic coupler including a cylindrical cavity, at least a portion of the containment can being located within the cylindrical cavity, the external magnetic coupler being configured for rotationally coupling to the cylindrical internal magnetic coupler;
wherein the rotational pumping element, the pumping chamber, and the pump housing are formed from an electrically non-conducting plastic with electrically conducting particles;
wherein the drive shaft is formed from an electrically semi-conducting ceramic;
wherein the electrically non-conducting plastic includes polytetrafluoroethylene;
wherein the electrically conducting particles include graphite;
wherein the electrically semi-conducting ceramic includes sintered silicon carbide;
wherein the magnetic coupler receptacle is cylindrically shaped and includes a dome shaped end cap; and
wherein any one of: the pump housing is formed by machining, the rotational pumping element is formed by machining, the pumping chamber is formed by machining, the sealed internal chamber is formed by machining, and combinations thereof.

US Pat. No. 10,188,998

CATALYST ROLLER FOR GRAVITY-ASSISTED PARTICLE FLOW

EXXONMOBIL RESEARCH AND E...

1. A catalyst roller system, comprising:a roller volume comprising a top interior surface, a sidewall, and an inner contour surface;
a plurality of catalyst particles within the roller volume, the plurality of catalyst particles comprising an average catalyst particle diameter, the catalyst particles having an angle of repose and an angle of internal friction;
a catalyst inlet in fluid communication with the roller volume via the top surface;
a catalyst exit in fluid communication with the roller volume; and
a catalyst roller disc rotatably mounted within the roller volume, a contour clearance between the mounted catalyst roller disc and the inner contour surface being less than half of the average catalyst particle diameter for at least one location,
wherein a catalyst stoppage angle defined by
a) a top of the mounted catalyst roller disc,
b) an intersection of the catalyst inlet and the top interior surface at the closest intersection point to the top of the mounted catalyst roller disc, and
c) a tangent line passing through the top of the mounted catalyst roller disc,
has a value within 15% of the angle of repose.

US Pat. No. 10,188,996

POWDER MIXING APPARATUS AND METHOD OF USE

Adamis Pharmaceuticals Co...

1. A powder mixing apparatus comprising:a first powder input portion comprising a first dispensing device;
a venturi tube;
a first mixing portion comprising a first powder inlet, a first gas inlet, and
a first mixing cavity;
wherein the first dispensing device comprises a first opening configured to dispense a first premixed powder through the venturi tube and into the first mixing portion;
wherein the first premixed powder comprises at least two micronized powders;
wherein the first gas inlet is configured to provide a first flow of a pressurized gas into the first mixing cavity; and
wherein the gas and the first premixed powder interact in the first mixing cavity to form a first post-mixed powder.

US Pat. No. 10,188,995

METHOD FOR PREPARING COMPOUND DISPERSOIDS OF HYDROPHOBIC NANOPARTICLES AND SURFACTANTS

CHINA UNIVERSITY OF PETRO...

1. A method for preparing a complex dispersion of hydrophobic nanoparticles and surfactants with a dispersion apparatus,wherein the dispersion apparatus comprises a water supply pipeline, a complex mixing pipeline and a material collecting pipeline;
the complex mixing pipeline comprises an ultrasonic disperser and a fluid reservoir that are connected in series, and a first plunger pump for one-way circulation of materials is provided between the ultrasonic disperser and the fluid reservoir;
the water supply pipeline is connected with a top of the ultrasonic disperser;
the material collecting pipeline is connected with a material outlet of the fluid reservoir;
the ultrasonic disperser comprises an instrumental barrel, a first ultrafiltration membrane and a second ultrafiltration membrane are disposed in the instrumental barrel up and down in succession which divide the instrumental barrel into three cavities, which are: a first cavity with a first ultrasonic emission probe disposed therein, a second cavity with a second ultrasonic emission probe disposed therein and a third cavity; a wall of the instrumental barrel is provided with a through surfactant delivery pipe connected to the first cavity; and the wall of the instrumental barrel is provided with a through hydrophobic nanoparticles delivery pipe connected to the second cavity;
wherein the method comprises the following steps:
(1) the first and second ultrafiltration membranes of suitable aperture sizes are selected according to experimental requirements, the second ultrafiltration membrane is mounted on a second snap ring first, and then the first ultrafiltration membrane is mounted on a first snap ring;
(2) a top cap of the ultrasonic disperser is fastened down, surfactants are added into the first cavity of the ultrasonic disperser through the surfactant delivery pipe, and hydrophobic nanoparticles are added into the second cavity of the ultrasonic disperser through the hydrophobic nanoparticle delivery pipe; the surfactant delivery pipe and the hydrophobic nanoparticle delivery pipe are closed after delivery;
(3) water in a water reservoir is injected into the ultrasonic disperser by the first plunger pump;
(4) after the water is injected, the hydrophobic nanoparticles and the surfactants are enabled to carry out one-way circulation in the complex mixing pipeline by a second plunger pump, and the first and second ultrasonic emission probes are started; during the process of water circulation in the ultrasonic disperser, at first, water is mixed with the surfactants in a upper room of the ultrasonic disperser, a dispersion solution of surfactants and water is formed under ultrasonic cavitation effects of the first ultrasonic emission probe and enters the second cavity through the first ultrafiltration membrane, part of the solution that meets not the standard of the first ultrafiltration membrane size is detained in the first cavity without entering the second cavity until the particle size thereof meets the standard of the first ultrafiltration membrane size after ultrasonic cavitation by the first ultrasonic emission probe;
(5) the dispersion solution of surfactants and water entering the second cavity is mixed with the hydrophobic nanoparticles;
(6) the complex dispersion of hydrophobic nanoparticles dispersed into suitable sizes and surfactants enters into the third cavity through the second ultrafiltration membrane, and then is cycled to the ultrasonic disperser through the fluid reservoir and the second plunger pump;
(7) steps (1) to (6) are repeated and cycled to form the complex dispersion of hydrophobic nanoparticles and surfactants;
(8) the complex dispersion of hydrophobic nanoparticles and surfactants is cycled to the fluid reservoir;
(9) connection between the material collecting pipeline and the fluid reservoir is enabled, the dispersion is collected to a complex dispersion reservoir by a third plunger pump.

US Pat. No. 10,188,990

DEVICE AND METHOD FOR POSITIONING A DETONATOR WITHIN A PERFORATING GUN ASSEMBLY

DynaEnergetics US, Inc., ...

1. A detonator positioning device for positioning a wireless detonator in a perforating gun assembly, the device comprising:a cylindrical body comprising an open end, a closed end, and a central bore adapted for receiving the detonator, the central bore extending along at least some of a length of the cylindrical body, the central bore including an enlarged bore portion adjacent the open end of the cylindrical body;
a plurality of arms extending toward the open end of the cylindrical body and at least partially enclosing the enlarged bore portion of the central bore, each of the plurality of arms adapted to retain a detonator head of the detonator when the detonator is positioned within the enlarged bore portion of the central bore; and
a plurality of legs extending from the cylindrical body and toward the closed end of the cylindrical body, each of the plurality of legs adapted to position the cylindrical body in the perforating gun assembly.

US Pat. No. 10,188,985

ZEOLITE AND REDOX OXIDE COMBINED CATALYST BODY

Corning Incorporated, Co...

1. A method for treating an exhaust stream containing NOx gas comprising contacting a catalytic structure with the exhaust stream, the catalytic structure comprising a first oxide selected from the group consisting of tungsten oxides and vanadium oxides, a second oxide selected from the group consisting of cerium oxides, lanthanum oxides, zirconium oxides, and combinations thereof, and a zeolite, the method further comprising contacting the catalytic structure with the exhaust stream containing NOx gas, wherein the catalytic structure is substantially free of platinum, palladium, and rhodium, and wherein an external layer of the catalytic structure comprises a mixture of the first oxide and the second oxide without the zeolite on a layer comprising the zeolite.

US Pat. No. 10,188,982

METHOD AND INDUSTRIAL PLANT FOR OBTAINING HELIUM FROM A HELIUM-CONTAINING FEED GAS

LINDE AKTIENGESELLSCHAFT,...

1. A method for obtaining helium from a helium-containing feed gas, said method comprising:feeding the helium-containing feed gas to a prepurifying unit wherein undesirable components are removed from the helium-containing feed gas in a pressure swing adsorption process to obtain a prepurified feed gas;
feeding the prepurified feed gas to a membrane unit connected downstream of the prepurifying unit, said membrane unit having at least one membrane which is more permeable to helium than to at least one further component present in the prepurified feed gas, to produce a pressurized low-helium retentate stream;
feeding said pressurized low-helium retentate stream from the membrane unit to the prepurifying unit; and
displacing helium-rich gas with the aid of the pressurized low-helium retentate stream from an adsorber to be regenerated in the prepurifying unit into an already regenerated adsorber of the prepurifying unit.

US Pat. No. 10,188,980

COAL UPGRADE PLANT AND METHOD FOR MANUFACTURING UPGRADED COAL

MITSUBISHI HEAVY INDUSTRI...

1. A coal upgrade plant comprising:a dryer for heating and drying coal before pyrolyzing the coal;
a scrubber for treating a carrier gas discharged from the dryer while catching a desorbed component desorbed from the coal when the coal is dried by the dryer, and causing at least one of mercury and mercury-based substances contained in the carrier gas to be adsorbed to an absorber for removal thereof;
a waste water treatment equipment for separating waste water collected from the scrubber into a solid content and recycled water;
a water demanding section for using the recycled water treated in the waste water treatment equipment; and
a carrier gas cooler that is provided on an upstream side of the scrubber to cool the carrier gas discharged from the dryer by using cooling water,
wherein the water demanding section is a cooling water feed section that feeds the cooling water to the carrier gas cooler, and uses the recycled water as the cooling water.

US Pat. No. 10,188,977

POLYMERIC NETTING OF RIBBONS AND STRANDS AND METHODS OF MAKING THE SAME

3M Innovative Properties ...

1. An absorbent article comprising a polymeric netting, a liquid impermeable backsheet, and an absorbent core, wherein the polymeric netting comprises polymeric ribbons and polymeric strands, each of the polymeric ribbons and strands having a length and width, wherein the length is the longest dimension and the width is the shortest dimension, wherein the polymeric ribbons have a height-to-width aspect ratio of at least three to one, a major surface that is intermittently bonded to only one polymeric strand, and a height that is greater than a height of the one polymeric strand, and wherein the absorbent core is between the polymeric netting and the backsheet, wherein the polymeric netting is between the absorbent core and the backsheet, or wherein the polymeric netting is within the absorbent core.

US Pat. No. 10,188,976

AIR PURIFIER, METHOD FOR DETERMINING TIME TO REPLACE FILTER THEREOF, AND DEVICE AND METHOD FOR DETERMINING FILTER REPLACEMENT TIME PRESSURE DIFFERENTIAL THEREFOR

COWAY CO., LTD., Chungch...

1. An air purifier comprising:a memory storing flow rate/differential pressure correlation graphs according to respective filter usage states;
a differential pressure sensor measuring differential pressure as a pressure difference between a front end of the filter and a rear end of the filter; and
a filter replacement time management unit determining a time to replace the filter according to a result of matching a differential pressure of the filter measured by a differential pressure sensor in every preset period and a flow rate of air introduced to the filter at the time of measuring the differential pressure to the flow rate/differential pressure correlation graph according to each usage state;
wherein the memory stores flow rate/differential pressure correlation graphs regarding a plurality of filters, identifies a filter having a graph matched to an initial differential pressure measured by the differential pressure sensor at an initial installation stage and a flow rate of air introduced to the filter at the time of measuring the initial differential pressure on the basis of a flow rate/differential pressure graph of an initial usage stage regarding a plurality of filters, selects a flow rate/differential pressure correlation graph of a replacement time state of the identified filter, and use the selected graph in determining a time to replace the filter.

US Pat. No. 10,188,975

HONEYCOMB AIR FILTER AND METHODS THEREOF

Corning Incorporated, Co...

1. An air filter, comprising:at least one wall-flow honeycomb particulate filter having at least one coat on at least a portion of an interior surface of the at least one wall-flow honeycomb particulate filter, the at least one coat comprising a sorbent and a Pt/TiO2 catalyst, wherein the sorbent forms islands or clusters dispersed within pores of the at least one wall-flow honeycomb particulate filter and the Pt/TiO2 catalyst forms separate islands or clusters that are dispersed within the pores of the at least one wall-flow honeycomb particulate filter; and
the air filter, in-use, retains from filtered air a particulate and a volatile organic compound, wherein the volatile organic compound is formaldehyde.

US Pat. No. 10,188,972

WATER PURIFYING APPARATUS AND FILTER STRUCTURE

LG ELECTRONICS INC., Seo...

1. A water purifying apparatus, comprising:a head having a water inlet portion and a water outlet portion formed thereon to face each other;
a mounting member on which a rotation supporting portion is formed;
a water inlet pipe and a water outlet pipe which are connected to the mounting member;
a shaft provided in the head, the shaft being rotatably mounted between the water inlet portion and the water outlet portion;
a bypass flow path formed to pass through a circumference of the shaft, the bypass flow path having a flow path projecting portion, the bypass flow path communicably coupling the water inlet portion with the water outlet portion according to a rotation of the shaft;
a filter detachably mounted to the head and having a filter inserting portion in which the shaft is inserted; and
a filtering flow path in which an inlet port and an outlet port are formed on the circumference of the shaft in a direction intersecting the bypass flow path, the filtering flow path communicably coupling the filter with the water inlet portion and the water outlet portion according to the rotation of the shaft.

US Pat. No. 10,188,971

ROTARY DISC FILTER AND MODULE FOR CONSTRUCTING SAME

1. A rotary disc filter for filtering a liquid comprising:a. a rotary drum for receiving the liquid and having a plurality of drum openings for permitting the liquid to flow from the drum;
b. one or more disc-shaped filter members secured around the drum;
c. each disc-shaped filter member including a plurality of compartments configured to receive liquid from the drum and to hold the liquid;
d. the compartments disposed around the drum with each compartment being disposed between and next to two other compartments;
e. each compartment being bound, at least in part, by opposed edges and on opposite sides by two filters;
f. wherein liquid held in the compartments is filtered by flowing outwardly through the filters on opposite sides of the compartments;
g. a drive for rotatively driving the drum and causing the disc-shaped filter members and the compartments thereof to rotate with the drum; and
h. openings formed in the edges of the compartments and configured to:
(i) substantially reduce the entrainment of liquid in the compartments by the rotary motion of the disc-shaped filter member and the compartments; and
(ii) pass substantially all of the liquid held in one compartment to an adjacent trailing compartment in response to the disc-shaped filter member rotating.

US Pat. No. 10,188,970

ROTARY DRUM SCREEN FOR THIN STILLAGE FILTRATION

WATER SOLUTIONS, INC., S...

1. A rotating drum screen system for separating solids from an influent material stream comprising:a housing having an influent inlet at an influent inlet end, a solid discharge end and an area between the influent inlet end and the solid discharge end, the influent inlet permitting a flow of influent containing solids in a flowing fluid into a hollow portion of a drum screen positioned lengthwise in the area between the influent inlet end and the solid discharge end, the drum screen comprising a filter screen that retains at least a portion of the solids within the hollow portion of the drum screen and which produces a liquid effluent that is discharged from an outer surface of the drum screen, the retained solids being removable from the drum screen via the solid discharge end, wherein the filter screen has a size in the range of 25 ?m and 150 ?m; and
a head box disposed within the hollow portion of the drum screen proximate the influent inlet end and in fluid communication with the influent inlet, the head box comprising a plurality of parallel fluid flow channel dividers dividing an influent stream received at the influent inlet into a plurality of parallel ongoing streams and directing the plurality of ongoing streams outwardly against the drum screen.

US Pat. No. 10,188,969

FILTER DEVICE

11. A filter device, comprising:a filter housing having a filter head, a filter bowl and a removable housing cover part;
a filter element separating a non-filtrate side from a filtrate side in said filter housing and having an element cap thereon forming an enclosure for an end of filter material of said filter element facing said cover part;
a bypass valve having a valve closure element preloaded by a closing spring into a closed position of said bypass valve in which said valve closure element bears against a valve seat part in a blocked position of said filter element, said bypass valve opening a fluid path from said non-filtrate side to said filtrate side bypassing said filter element, said valve closure element and said closing spring being on said cover part, said valve seat part being on said element cap;
an annular receiving part on said element cap at said enclosure, said receiving part being a planar circular ring, a guide part being connected to an internal circumference of said receiving part and extending axially into an inner side of said filter element forming said non-filtrate side, said valve seat part being on said guide part, said guide part being a hollow cone extending with a tapered end thereof having an opening within said inner side of said filter element, an edge of said opening forming a sealing edge of said valve seat part.

US Pat. No. 10,188,964

CHROMATOGRAPHY COLUMNS

REPLIGEN CORPORATION, Wa...

1. A method of making and loading a chromatography column, the method comprising:selecting a column tube that has an inner surface having an inner diameter and a length to accommodate a volume of packing medium, the column tube having an elasticity and a wall thickness;
selecting first and second flow distributors each having an outer circumferential surface having an outer diameter;
permanently securing the first flow distributor to a first end of the column tube;
loading the packing medium into the column tube;
inserting the entire second flow distributor into a second end of the column tube, wherein the outer diameter of the second flow distributor is larger than the inner diameter of the column tube before the second flow distributor is inserted into the second end of the column tube, by applying an axial force sufficient to drive the second flow distributor into the column tube, expand the inner diameter of the column tube, and establish an interference fit between the outer circumferential surface of the second flow distributor and the inner surface of the column tube to form a sealed chamber within the column tube between the first and second flow distributors, wherein the interference fit enables the chromatography column to withstand operational pressures and maintain a hydraulic seal without the second flow distributor being permanently secured in position;
after inserting the second flow distributor and establishing the interference fit, adjusting a longitudinal position of the second flow distributor within the column tube by (i) applying an additional axial force to move the second flow distributor further into the column tube, or (ii) forcing liquid into the sealed chamber to apply a hydraulic force to move the second flow distributor back towards the second end of the column tube, or any combination of (i) and (ii); and
when the second flow distributor has reached a final longitudinal position, permanently securing the second flow distributor within the column tube at the final longitudinal position.

US Pat. No. 10,188,963

REACTOR FOR BIOLOGICAL OR CHEMICAL TRANSFORMATION

SPINCHEM AB, Umea (SE)

1. A reactor for performing, by means of at least one solid reaction member(s), a biological or chemical transformation, or physical or chemical trapping from, or release of agents to, a fluidic media, said reactor comprising a cylindrical reactor vessel having a first end part, a second end part, and an inner wall between these parts, in which reactor vessel a transformation device has been mounted, said transformation device comprisinga flow distributor having an essentially cylindrical shape, a first essentially flat surface, a second essentially flat surface, and a peripheral wall having an essentially circular cross-section, at least one fluid medium inlet located in vicinity of the centre of said first and/or second surface, said at least one fluid medium inlet being adapted for receiving fluid medium and optionally being adapted for receiving initially suspended solid reaction member(s), at least one fluid medium outlet permeable for said fluid medium but impermeable for solid reaction member(s), said outlet(s) being located on said peripheral wall, a driving shaft located on said first surface for enabling rotation or oscillation of the flow distributor, and at least one confinement wherein said solid reaction member(s) can be trapped and said transformation is performed; and
a means for rotating and/or oscillating the device; wherein said inner wall of the reactor vessel comprises means for enhancing the fluidic shear stress in any of the two rotary directions along said inner wall between said first end part and said second end part,
wherein said means for enhancing the fluidic shear stress is at least one hollow structure in said wall, said hollow structure(s) extending in a direction from said first end part to said second end part, said hollow structure(s) having open ends above and below said flow distributor and a through-going channel there between, thereby facilitating communication between the fluidic medium above and below the flow distributor.

US Pat. No. 10,188,962

GRID-BASED VIRTUAL REALITY ATTRACTION SYSTEM

Unchartedvr Inc., San Ra...

1. A grid-based virtual reality (VR) attraction system, comprising:a grid aligned stage kit that corresponds to a plurality of stage plans associated with plurality of VR representations, said grid aligned stage kit comprising:
fixed accessories;
moveable accessories;
a stage comprising a platform having a pattern of markings along at least two dimensions, wherein said stage is configured with accessory mounts arranged on said platform, for affixing said fixed stage accessories to said platform, and wherein said pattern identifies coordinates corresponding to a location of said accessory mounts; and
a plurality of stage sections that are configured to be interconnected according to said pattern to form said platform, wherein said platform is configurable according to said plurality of stage plans comprising at least A×B and C×D, wherein A, B, C, and D are different from each other;
a motion tracking system, configured to track identity, location, and/or orientation of a VR participant on said stage; and
a VR simulation engine, coupled to said motion tracking system, configured to receive said identity, location, and/or orientation, and configured to generate said plurality of VR representations to simulate a virtual environment with virtually represented objects whose locations and orientations correspond to locations and orientations said fixed and moveable accessories that are arranged according to a corresponding stage plan.

US Pat. No. 10,188,959

TOY TRACK SETS

Mattel, Inc., El Segundo...

1. A toy track set for a toy vehicle, comprising:a first track section having a first travel surface and a first tubular connector at a first connecting end of the first travel surface; and
a second track section that is configured to be rotatably coupled to the first tubular connector, the second track section includes a second travel surface having first and second travel portions, the second track section is configured to rotate relative to the first track section between a first position in which the first travel surface forms a continuous travel path with the first travel portion, and a second position in which the first travel surface forms a continuous travel path with the second travel portion.

US Pat. No. 10,188,956

ASSEMBLY-TYPE EVOLUTIONARY GAME SYSTEM

ORGANIC CONSTRUCTION SYST...

1. An assembly-type evolutionary game system comprising the following components:a) extendable components of a base body which comprise:
a body abdomen-side part (8);
a first body back-side part (9);
a second body back-side part (10);
a third body back-side part (11);
a fourth body back-side part (12);
a fifth body back-side part (13); and
a sixth body back-side part (14);
wherein the extendable components include an internal extension metal array to extend and adjust proportions of the extendable components,
b) malleable structural joint pieces of the base body which comprise:
a short straight connection structural joint piece (1) with an end comprising a straight connection piece;
a middle straight connection structural joint piece (5) with an end comprising a straight connection piece;
a long straight connection structural joint piece (7) with an end comprising a straight connection piece;
a middle spherical connection structural joint piece (3) with an end comprising a spherical connection piece;
a long spherical connection structural joint piece (6) with an end comprising a spherical connection piece;
a mixed connection structural joint piece (2) with an end comprising a straight connection piece; and
a hand structural joint piece (4) including a hand connection piece;
wherein the malleable structural joint pieces are configurable to hold a shape after adjustment, and
c) rigid components of the base body which comprise:
a plurality of separate body parts, wherein each separate body part encloses a hollow portion and at least one clamp located at a curved portion of the body part and extending inwardly into the enclosed hollow portion within each separate body part, the plurality of separate body parts comprising:
a narrow rib (15);
a narrow limb connection main body (16);
a flat rib (18);
a flat limb connection main body (19),
wherein each of the plurality of separate body parts is configured to connect to at least one of the malleable structural joint pieces extending through the hollow portion using the at least one clamp thereon;
a plurality of additional rigid components comprising:
a thigh (17);
a knee (20);
an ankle (21);
a foot (22);
a wing (23);
a shin (24);
a fish tail piece (25) or a single tail piece (26);
a reptile head (27) or a fish head (29) comprising a skull and a jaw;
a crest (28);
a head connection component (30);
a front arm (31);
an elbow and wrist component (32); and
an arm (33),
wherein the extendable components connect to the malleable structural joint pieces, and
wherein coupling the components enables a formation of assembled components to create a diverse number of animals.

US Pat. No. 10,188,952

METHOD FOR DYNAMICALLY MAPPING SERVERS

Controlled Protocols, Inc...

1. A non-transitory computer readable medium including a program of instructions for dynamically mapping a plurality of servers that when executed by a computer performs the steps of:defining a three dimensional area of a virtual space divided into independently storable blocks with an integral coordinate system by providing coordinate addresses that have an X, Y and Z component, wherein each component includes a summary address portion and an internal address portion;
mapping coordinate addresses that represent a position within the virtual space to server coordinates, wherein the coordinate address includes an embedded and freely assignable server address so that each block can be transferred and independently stored on one or more of the plurality of servers;
adding a block to any one of the plurality of servers to expand beyond the defined three dimensional area; and
dynamically re-mapping the coordinate address to reflect the new server coordinates of the added block.

US Pat. No. 10,188,951

SYSTEM AND METHOD FOR PROVIDING A QUEST FROM A PROBABILITY ITEM BUNDLE IN AN ONLINE GAME

Kabam, Inc., San Francis...

1. A system for providing access to quests from probability item bundles in an online game, the system comprising:one or more physical computer processors configured by machine-readable instructions to:
execute an instance of the online game, and to implement the instance of the online game to facilitate participation of users in gameplay of the online game, via client computing platforms that are associated with the users;
maintain inventories of virtual items under control of the users, and to store associations between the users and the virtual items which the users control in the online game;
effectuate presentation to the users, through a shop interface, offers to sell probability item bundles, individual ones of the probability item bundles being associated with sets of potential awards for the online game, the probability item bundles including a first probability item bundle being associated with a first set of potential awards, the first set of potential awards including a first potential award and a second potential award, the first potential award providing access to a first quest in the online game;
wherein the potential awards in the sets of potential awards are associated with different award distribution probabilities such that the first potential award is associated with a first award distribution probability and the second potential award is associated with a second award distribution probability;
wherein purchase of the probability item bundles by the users results in addition, via the one or more physical computer processors, of purchased probability item bundles to the inventories of the users such that responsive to purchase of the first probability item bundle by a first user, the first probability item bundle is added to a first inventory of virtual items under control of the first user; and
receive activation requests from the users for the purchased probability item bundles under user controlled inventories, and to stochastically distribute the potential awards to the users in accordance with the award distribution probabilities associated with the potential awards such that, in response to receiving an activation request from the first user for the first probability item bundle subsequent to purchase of the first probability item bundle by the first user, one of the potential awards is stochastically selected from the first set of potential awards in accordance with the award distribution probabilities associated with the potential awards such that the first potential award is selected.

US Pat. No. 10,188,950

METHOD AND APPARATUS FOR PROVIDING PRIVACY POLICY GENERATION BASED ON IN-GAME BEHAVIOR DATA

Nokia Technologies Oy, E...

1. A method comprising:determining, by at least one processor, in-game behavior data associated with user information restricted by at least one user with respect to other users at at least one in-game location while the at least one user is playing at least one location-based game, wherein the at least one location-based game models the at least one in-game location based on an equivalent real-world location, and the location-based game directs the at least one user to visit the equivalent real-world location when playing the location-based game;
causing, at least in part by the at least one processor, a mapping of the in-game behavior data that occurs at the at least one in-game location within the at least one location-based game to the equivalent real-world location; and
causing, at least in part by the at least one processor, a generation of one or more privacy policies based, at least in part, on the in-game behavior data, wherein the one or more privacy policies permit and restrict access to the user information via at least one device of the at least one user by another user when the at least one device is detected as located at the equivalent real-world location based on sensor data from the at least one device, wherein the user information includes one or more interests, one or more activities, one or more social links, or a combination thereof of the at least one user.

US Pat. No. 10,188,949

GAME OBJECT CONTROL SYSTEM AND PROGRAM

EARTHBEAT, INC., Shibuy-...

1. A game object control system which invokes various event processes to progress a game in a virtual world where a character corresponding to a user and other objects move, comprising:a game progress processing unit which progresses the game by invoking the various event processes;
a real map storage unit which stores real map information containing geographical information in a real world;
a virtual map information generation unit which generates virtual map information including coordinate information of the objects on virtual geographical information corresponding to the geographical information on the real map information in accordance with a game progress by the game progress processing unit;
a positional information acquisition unit which selects a coordinate position in the real world;
a real display data generation unit which generates real display data indicating the coordinate position selected by the positional information acquisition unit on the real map information on the basis of the coordinate position;
a virtual display data generation unit which generates virtual display data showing the character on the virtual map information corresponding to the coordinate position acquired by the positional information acquisition unit on the basis of the coordinate position;
a moving path recording unit which calculates and records a moving path on the basis of a displacement history of the coordinate position selected by the positional information acquisition unit;
a trail display unit which displays, as trails, the moving path recorded by the moving path recording unit on the real map information or the virtual map information; and
a display control unit which displays both or selected one of the virtual display data generated by the virtual display data generation unit and the real display data generated by the real display data generation unit, or displays part of either one overlapping the other, together with the trail displayed by the trail display unit,
wherein the positional information acquisition unit acquires the current position of another user in the real world, and selects, as the coordinate position, the position in which an object to be a proxy of the user is arbitrarily set on the real map information or the virtual map information as a proxy object, and
wherein the game progress processing unit sets the position of the proxy object in the map information on the basis of the position of the another user, and automatically moves the proxy object in accordance with the progress of the game.

US Pat. No. 10,188,946

SYSTEM AND METHOD FOR DYNAMICALLY ALTERING AN IN-GAME EXPERIENCE BASED ON A USER'S CONNECTION TO THE GAME

Kabam, Inc., San Francis...

1. A system for dynamically altering an in-game experience for an online game based on a signal strength, the system comprising:one or more processors configured by machine-readable instructions to:
to execute a game instance of a game space for the online game, and to use the game instance of the game space to generate state information that is transmitted over a network to client devices associated with users, wherein transmission of the state information facilitates presentation of views of the game space to the users, and to implement the game instance of the game space to facilitate interaction of the one or more users with the game space and/or each other by performing operations in the game space in response to commands received over the network from the client devices associated with the users, wherein the online game has one or more modes of gameplay in which individual ones of the modes of gameplay include different types of operations performable in the game instance in response to the commands from the users, and wherein the users comprise a first user associated with a first device;
to determine the signal strength of the first device of the first user connected to the network;
perform a mode of gameplay determination by determining one or more of the modes of gameplay to be made available to the first user from a set of modes of gameplay based on the determined connection strength; and
alter availability of one or more of the modes of gameplay to be made available to the first user responsive to the determined signal strength being below a threshold signal strength.

US Pat. No. 10,188,945

GENERATION OF GAMEPLAY VIDEO BASED ON SOCIAL NETWORK SHARING

Sony Interactive Entertai...

1. A method for generating a gameplay video of a video game, comprising:executing, by a cloud gaming system that includes at least one server computer, a session of a video game, the session defining a user's gameplay of the video game, the session being streamed to a client device;
recording, by the cloud gaming system, the user's gameplay of the video game;
analyzing, by the cloud gaming system, the user's recorded gameplay to determine a region of interest, the region of interest being a region of the video game having social network sharing levels that exceed a predefined threshold, wherein the social network sharing levels are defined based on prior sharing to the social network of gameplay videos from prior sessions of the video game;
during the session of the video game, receiving, by the cloud gaming system, a request from the client device, the request being initiated from a button of a controller device interfaced to the client device;
responsive to the request, presenting, by the cloud gaming system through the client device, the region of interest;
generating, by the cloud gaming system, a gameplay video of the video game based on the region of interest;
sharing the gameplay video of the video game over the social network to one or more additional client devices for viewing by one or more additional users.

US Pat. No. 10,188,944

FACILITATING USERS TO COMPLETE ACTIVE GAME ACTIONS

Kabam, Inc., San Francis...

1. A game server for providing offers to facilitate users to complete game actions within an online game, the game server comprising:one or more physical processors configured by machine-readable instructions to:
execute an instance of a game space in which the online game is played, and enable interaction of the users with the game space and/or each other by executing game actions on behalf of the users, wherein the game actions including game actions that require wait periods for completion; and
generate offers to remove and/or reduce the required wait periods of the game actions in exchange for consideration from the users, wherein the offers generated for the first user include:
a first offer to remove and/or reduce a first pending wait period required for completion of a first game action in exchange for a first amount of consideration;
a second offer to remove and/or reduce a second pending wait period required for completion of a second game action in exchange for a second amount of consideration; and
a third offer to remove and/or reduce both of the first pending wait period and the second pending wait period in exchange for a third amount of consideration.

US Pat. No. 10,188,936

SIDED GAME ACCESSORY DEVICE

1. A sided device comprising:A housing, the housing including a plurality of sides to form an enclosure, the housing further including a plurality of components, comprising:
an actuator;
a sound sensor;
a light emitter;
a timer;
a randomizer;
a microprocessor; and
a source of electric power;the actuator and microprocessor in electronic communication with the sound sensor, the light emitter, the timer, the randomizer and the source of electric power, wherein the force, speed and/or direction of the actuator is determined by one or more of the sound from an external source, the timer and the randomizer; the actuator having a movable end, the actuator mounted within the enclosure and positioned such that when actuated, the movable end contacts a side, causing movement of the sided device; the actuator positioned within the housing and at an angle, the angle ranging from 1 degree to 89 degrees, with respect to the sides proximate the ends of the actuator.

US Pat. No. 10,188,934

ICE SKATE AND RUNNER THEREFOR

SPORT MASKA INC., Montre...

1. An ice skate comprising:a boot adapted for receiving therein a foot of a wearer of the skate;
a holder mounted to a sole of the boot and having at least one attachment point thereon; and
a runner mounted to the holder and secured in place thereon via the at least one attachment point, the runner being entirely metal and extending a length along a longitudinal axis between a front end and an opposed rear end of the runner, the runner having a height extending between an ice-contacting portion for engaging an ice surface and an opposed upper portion of the runner, opposed outer and inner side surfaces of the runner defining a datum runner thickness extending therebetween, and one or more regions of reduced thickness in the runner that are recessed inwardly from at least one of the outer and inner side surfaces thereof, the one or more regions having a local thickness less than the datum runner thickness, at least one of the one or more regions of reduced thickness having a closed periphery being entirely surrounded by regions having a thickness greater than the local thickness.

US Pat. No. 10,188,931

SMART BASEBALL FIRST BASE OR HOME PLATE

Intel Corporation, Santa...

1. A smart base for a baseball system or a softball system, comprising:a sensor to detect a first time at which a runner has touched the smart base;
a radio-frequency (RF) receiver to receive a signal from a smart baseball that indicates a second time at which the smart baseball was caught;
timing circuitry to detect whether the second time occurs before or after the first time; and
indicator circuitry to indicate a force out when the second time occurs before the first time.

US Pat. No. 10,188,929

ADAPTED FITNESS EQUIPMENT

1. An exercise apparatus comprising:an adjustable frame being configured for attaching to an assistive ambulation device;
said adjustable frame including an upper frame portion and a lower frame portion;
said upper frame portion including a first upper frame member, a second upper frame member, and an upper frame horizontal support, said upper frame horizontal support being orthogonally connected to said first upper frame member and being orthogonally connected to said second upper frame member;
said lower frame portion including,
a first lower frame member having a first upper portion and a first lower portion, and
a second lower frame member having a second upper portion and a second lower portion, and
a lower frame horizontal support;
said lower frame horizontal support being orthogonally connected to said first lower frame member between said first upper portion and said first lower portion;
said lower frame horizontal support being orthogonally connected to said second lower frame member between said second upper portion and said second lower portion;
said first lower portion including a first fitting arm, said first fitting arm being configured for receiving a fitness attachment;
said second lower portion including a second fitting arm, said second fitting arm being configured for receiving the fitness attachment;
said first upper portion being co-linearly connected to said first upper frame member;
said second upper portion being co-linearly connected to said second upper frame member;
said first lower portion being bent;
said second lower portion being bent;
said first upper lower frame member being straight;
said second upper lower frame member being straight.

US Pat. No. 10,188,925

BALL REBOUNDING SYSTEM

SPORTWORX, LLC, Imperial...

1. A rebounder for a ball, comprising:a frame comprising a perimeter support and an interior space within the perimeter support;
a first pair of tension rods arranged parallel to each other on opposite sides of the interior space, wherein each of the tension rods is movable within the interior space between a first position in which each tensions rod is spaced apart from the perimeter support within the interior space, and a second position in which each tension rod is spaced apart from the perimeter support within the interior space but closer to the perimeter support than in the first position;
an inelastic net comprising a plurality of cells, wherein the net is disposed within the interior space of the frame, and wherein rows of the cells proximate to a boundary of the net are connected to the tension rods, and wherein the rows of the cells are directly laced onto the tension rods; and
a plurality of inelastic fasteners connecting the tension rods to the frame when the tension rods are in the second position;
wherein the net is in a slackened state when the tension rods are in the first position, and wherein the net is in a taut state when the tension rods are in the second position; and
wherein the perimeter support of the frame is straight when the tension rods are in the first position, and wherein the perimeter support is bowed inwardly toward at least one of the tension rods when the tension rods are in the second position.

US Pat. No. 10,188,924

BALL SPINNING TRAINING APPARATUS AND METHOD

1. An apparatus comprising:a bar having a length and a width, wherein the length is substantially greater than the width, and having a longitudinal axis along the length of the bar;
a member which is connected to the bar and aligned with the bar so that the member has a longitudinal axis which is the same as the longitudinal axis of the bar;
a fastener which is fixed to the bar so that the fastener does not rotate with respect to the bar;
a ball fixed to the member so that the ball does not rotate with respect to the member, but does rotate with respect to the bar;
wherein the member has a length along the longitudinal axis of the member;
wherein the fastener spans a majority of the length of the member and resides partly inside of the member; and
wherein a majority of the member and a majority of the fastener reside inside of the ball;
wherein the member is connected to the bar by the fastener so that the member rotates with respect to the bar, about the longitudinal axis of the bar;
wherein the ball has a bore hole formed into the ball, wherein the bore hole terminates inside a core of the ball, so that the bore hole does not go all the way through the ball;
wherein the member is fixed to the ball, by insertion of the member into the bore hole; and
wherein a majority of the member and the fastener reside in the bore hole;
wherein the bore hole of the ball has a diameter, which has a rest measurement, prior to insertion of the member, which is less than a diameter of the member, so that the bore hole diameter must expand by pressure, in order for the member to be inserted into the bore hole;
wherein the ball is a regulation softball that has been modified by having the bore hole drilled in the regulation softball;
further comprising a first ball bearing inserted in the member, nearer the first end of the member than the second end of the member, the first ball bearing residing inside of the ball, and within a first recess of the member; and
a second ball bearing inserted in the member, nearer the second end of the member than the first end of the member, the second ball bearing residing inside of the ball, and within a second recess of the member;
wherein the first recess of the member has an inner diameter;
wherein the second recess of the member has an inner diameter which is the same as the inner diameter of the first recess of the member;
wherein a central part of the member, which is located between the first recess and the second recess of the member, has an inner diameter which is less than the inner diameter of the first recess and less than the inner diameter of the second recess;
wherein each of the first and the second ball bearings has an outer diameter such that neither the first ball bearing nor the second ball bearing can fit in the central part of the member; and
wherein the central part of the member has a length which is substantially greater than a combination of a length of the first recess and a length of the second recess.

US Pat. No. 10,188,923

ATHLETIC TRAINING TOOL

BODY ARTS GYM, LLC, Phil...

1. An athletic training device for training a user to maintain proper swinging position, the device comprising:a mouth piece having symmetric top part and bottom part configured in a spring loaded clam-shell-like clip arrangement;
wherein said top part and bottom part each include:
a grasp portion,
a bite guard portion, and
a clip opening portion;
wherein the top and bottom grasp portions are separated by a spring that provides a preloaded closing force on the top and bottom opening portions in order to attach the mouth piece onto he collar or breast portion of a user's shirt;
wherein the top and bottom bite guard portions are each shaped to allow the user to bite while swinging athletic equipment and maintain proper head position; and
wherein the grasp portion is configured to allow the user to easily open and close the opening portions using their fingers or mouth.

US Pat. No. 10,188,921

MULTIPLE SPORT TRAINING DEVICE AND SPORT TRAINING SYSTEM

1. A multi-sport training system, comprising:a frame comprising a horizontal crossbar coupled to a pair of upright side members aligned perpendicular to the crossbar to create an open goal area;
a plurality of flexible panels having a plurality of attachment members configured for reversible attachment of each panel of the plurality of flexible panels to the crossbar, wherein the attachment members allow each panel to hang vertically from and rotate 360 degrees around the crossbar;
wherein each of the plurality of flexible panels include an adjustment means comprising horizontal rows of openings and vertical columns of openings;
a plurality of mating securement features affixed along a bottom of each of the plurality of flexible panels in alignment with the openings;
wherein each of the plurality of mating securement features is removably received within a selected horizontal row of openings allowing each panel of the plurality of flexible panels to be folded upwardly and secured thereto.

US Pat. No. 10,188,920

SCORING DEVICE FOR SCORING A SNOWBALL FIGHT

Peter Moloney, St. Paul,...

1. A scoring device to be worn by a person for scoring a snowball fight, the device comprising:a target portion including:
a target,
a permeable layer spaced apart from the target,
an interior region, including a scoring chamber, positioned between the permeable layer and the target, the interior region being substantially continuous without any openings; and
the scoring chamber portion positioned at the bottom of the interior region when the scoring device is worn by the person, the scoring chamber portion arranged to accumulate and store snow falling from the interior region
the scoring device except the permeable layer being substantially fluid-tight such that when snow passes through the permeable layer, snow is collected in the scoring chamber and prevented from leaving the scoring device.

US Pat. No. 10,188,919

GOLF TOWEL

1. A golf towel comprising:(a) a fabric towel body having a first side and a second side;
(b) a first abrasive portion secured to one side of the towel body and comprising a plurality of nubs projecting outwardly therefrom, each one of the plurality of nubs comprising an abrasive material that nests within an associated dimple on a golf ball; and
(c) a second abrasive portion secured to a side of the towel body and comprising a plurality of mounds projecting outwardly therefrom, the plurality of mounds being arranged in a plurality of linear and parallel rows, each one of the plurality of mounds comprising an abrasive material that nests within an associated groove on a golf club head.

US Pat. No. 10,188,917

WEIGHTED IRON SET

Acushnet Company, Fairha...

1. A set of golf clubs comprising at least a first club head having a loft between about 15 and 25 degrees, a second club head having a loft of between about 26 and 35 degrees, and a third club head having a loft of about 36 degrees or greater, wherein:the first, second and third club heads each comprise a heel, a toe, a topline, a sole, a hosel and a front face having a face center, each club head having a club head mass that is different than the previous club head by at least 5 grams, and wherein at least the first club head includes a back wall having an aperture and a weight member formed of tungsten and coupled to a toe portion of the back wall that comprises 15%-25% of the club head mass, wherein a mechanical fastener is inserted through the aperture from a face side of the club and extends through the aperture in the back wall to couple the weight member to the toe portion and a face member is welded to a face retaining surface forward of the mechanical fastener.

US Pat. No. 10,188,916

GOLF CLUB HEAD

TAYLOR MADE GOLF COMPANY,...

1. A golf club head, comprising:a body, defining an interior cavity and comprising:
a sole portion, positioned at a bottom portion of the golf club head;
a crown portion, positioned at a top portion of the golf club head;
a skirt portion, positioned around a periphery of the golf club head between the sole portion and the crown portion;
a forward region;
a rearward region;
a face portion, at the forward region of the body and comprising a strike face with an area of at least 3000 mm?2 and a maximum height from a ground plane of at least about 50 mm; and
at least one weight track formed in the sole portion;
at least one weight assembly, selectively adjustably positioned within the at least one weight track; and
at least one brace bar traversing the interior cavity between and attached to the at least one weight track and the crown portion, wherein a mass per unit length of the brace bar is between 0.005 g/mm and 0.40 g/mm;
wherein:
the body further comprises a frame;
the frame comprises a first crown opening, a second crown opening, and a spine portion defining the crown portion and separating the first crown opening from the second crown opening;
the crown portion comprises a crown insert attached to the spine portion and covering the first crown opening and the second crown opening; and
the at least one brace bar is attached to the spine portion.

US Pat. No. 10,188,914

GOLF CLUB HEAD

Bridgestone Sports Co., L...

1. A golf club head comprising a crown portion and a face portion, wherein the crown portion includes a first protruding portion arranged on a side of the face portion and extending from an upper end of the face portion to a back side, a second protruding portion arranged on the back side to be adjacent to the first protruding portion, and a valley portion formed where the first and second protruding portions are connected to one another, the second protruding portion has a convex-curved outer surface extending from the valley portion to a back side end of the crown portion, a width of the first protruding portion in a face-back direction on a plane passing through a face center of the face portion and extending in a vertical direction is smaller than a width of the second protruding portion in the face-back direction, and a protruding height of the second protruding portion is larger than a protruding height of the first protruding portion, wherein curved outer surfaces of the first and second protruding portions abut to form an inflection at the valley portion.

US Pat. No. 10,188,912

GOLF BALL

Acushnet Company, Fairha...

1. A two-piece golf ball having a diameter of 1.70 inches or greater, a weight of from 45 g to 46 g, an MOI of 86 g·cm2 or greater, and consisting essentially of a center and a cover layer, wherein the center has a diameter of 1.60 inches or greater, a positive hardness gradient of at least 3 Shore C units, and is formed from a highly neutralized polymer composition.

US Pat. No. 10,188,910

GOLF BALL

SUMITOMO RUBBER INDUSTRIE...

1. A golf ball comprising a spherical core and at least one cover covering the spherical core, whereina hardness difference D1 (H75?H0) between a hardness H75 at a point located at a distance of 75% of a core radius from a center of the spherical core and a center hardness H0 of the spherical core is 15 or more and 35 or less in Shore C hardness,
a hardness difference D2 (Hs?H75) between a surface hardness Hs of the spherical core and the hardness H75 at the point located at the distance of 75% of the core radius from the center of the spherical core is ?1 or more and 3.5 or less in Shore C hardness,
a hardness difference D3 ((H0+H75)/2?H37.5) between a hardness of (the center hardness H0 of the spherical core+the hardness H75 at the point located at the distance of 75% of the core radius from the center of the spherical core)/2 and a hardness H37.5 at a point located at a distance of 37.5% of the core radius from the center of the spherical core is 0.5 or more and 6.5 or less in Shore C hardness, and
a hardness difference D5 (H75?H50) between the hardness H75 at the point located at the distance of 75% of the core radius from the center of the spherical core and a hardness H50 at a point located at a distance of 50% of the core radius from the center of the spherical core is 10 or more in Shore C hardness.

US Pat. No. 10,188,909

GOLF BALLS HAVING A FOAM INNER CORE WITH THERMAL BARRIER

Acushnet Company, Fairha...

1. A golf ball, comprising a core assembly and a cover, the core assembly comprising:i) an inner core comprising a foam composition having a geometric center, outer surface, and thermal barrier layer, wherein the inner core layer has a diameter in the range of about 0.100 to about 1.100 inches and an outer surface hardness (Hinner core surface) and a center hardness (Hinner core center), the Hinner core surface being greater than the Hinner core center to provide a positive hardness gradient in the inner core and wherein the thermal barrier layer has a midpoint hardness (Hmidpoint of thermal barrier layer), and Hmidpoint of thermal barrier layer is greater than the Hinner core surface; and
ii) an outer core comprising a non-foamed thermoset or thermoplastic composition, the outer core layer being disposed about the inner core layer and having a thickness in the range of about 0.100 to about 0.750 inches, and an outer surface hardness (Houter surface of OC), wherein the (Houter surface of OC is greater) than the (Hinner core center) to provide a positive hardness gradient across the core assembly.

US Pat. No. 10,188,907

DIMPLE PATTERNS FOR GOLF BALLS

Acushnet Company, Fairha...

1. A golf ball having an outer surface comprising a plurality of dimples disposed thereon, wherein none of the dimples overlap or touch, and wherein the dimples are arranged in multiple copies of a first domain and a second domain, the first domain and the second domain being tessellated to cover the outer surface of the golf ball in a uniform pattern having no great circles and consisting of twenty first domains and twelve second domains, and wherein:the first domain has three-way rotational symmetry about the central point of the first domain;
the second domain has five-way rotational symmetry about the central point of the second domain;
the number of different dimple diameters on the outer surface, D, is related to the total number of dimples on the outer surface, N, such that
if N?252, then D>4;
if 2525; and
if N?362, then D>6; and
the plurality of dimples consists of a plurality of perimeter dimples and a plurality of interior dimples, wherein each of the plurality of perimeter dimples is located directly adjacent to a border segment of the first domain or a border segment of the second domain, and wherein each of the plurality of perimeter dimples has at least two nearest neighbor dimples that are located in a domain other than the domain of that perimeter dimple.

US Pat. No. 10,188,906

BALANCE REHABILITATION FOR UPPER-EXTREMITY TARGET TASKS

1. A balance rehabilitation apparatus including:a support system including a three-sided framework defining a workspace for one or more persons within the three-sided framework, the three-sided framework including a first side frame assembly, a second side frame assembly and a third side frame assembly disposed between the first and second side frame assemblies; and
one or more position-adjustable platforms releasably attachable to the three-sided framework;
wherein the three-sided framework provides a plurality of positions for securing the platforms thereto; and
wherein one of the one or more position-adjustable platforms includes a spanning position-adjustable platform releasably connected to the first side frame assembly at a first end and releasably connected to the second side frame assembly at a second end.

US Pat. No. 10,188,904

SWITCHABLE INTELLIGENT FITNESS HANDLE AND INTELLIGENT FITNESS SET INCLUDING THE SAME

EGGPLANT TECHNOLOGIES, G...

1. A switchable intelligent fitness handle, wherein a processor, a movement posture sensor and a touch sensor are built in the handle;the movement posture sensor and the touch sensor are connected respectively to the processor;
one end of the handle is closed; a bayonet is arranged at the other end of the handle;
the bayonet is switchable and hot-pluggable, configured to connect respectively to a plurality of handheld fitness equipments;
a pin connector matched with the bayonet is arranged in each of the plurality of handheld fitness equipments;
when the handle is connected to one of the plurality of handheld fitness equipments, the processor receives an equipment identification number transmitted by the handheld fitness equipment through the pin connector, collects movement information of the corresponding handheld fitness equipment based on the received equipment identification number, and uploads the movement information to a mobile terminal or a cloud server.

US Pat. No. 10,188,903

DETERMINING A SPEED OF A MULTIDIMENSIONAL MOTION IN A GLOBAL COORDINATE SYSTEM

1. A method for determining a speed of a multidimensional motion of an athlete in a global coordinate system based on multidimensional acceleration data from a multidimensional accelerometer placed at a movable limb of the athlete, the movable limb being at least one of translatory and rotatable, and the movable limb defining a local coordinate system, the method comprising:determining, based on the multidimensional acceleration data, at least one correction quantity taking into account a rotation of the local coordinate system relative to the global coordinate system during the multidimensional motion; and
determining the speed of the multidimensional motion based on an integration of the multidimensional acceleration data and in consideration of the at least one correction quantity; and
detecting at least one of the multidimensional motion and a period of motion inactivity based on at least one of (i) detecting an excess of an acceleration threshold using the multidimensional acceleration data, (ii) detecting a saturation of one or more dimensions of the multidimensional acceleration data, and (iii) detecting an oscillation of the multidimensional acceleration data.

US Pat. No. 10,188,901

TORSO MUSCLE AND SPINE EXERCISE APPARATUS

1. An exercise apparatus, comprising:a base;
a supporting surface carried by the base, the supporting surface to receive a weight bearing portion of a user's body;
a support frame carried by the base;
a stationary pelvic belt receiving frame carried by the support frame;
a pelvic belt rotatably received within the stationary pelvic belt receiving frame and configured to securely receive a pelvic area of the user's body for rotation therewith;
one or more mechanical force resistors carried by the support frame and operably coupled to the pelvic belt so as to impart resistance to rotation of the pelvic belt relative to the stationary pelvic belt receiving frame,
wherein the stationary pelvic belt receiving frame includes a front quadrant, a plurality of pulleys are disposed in the front quadrant, and the weight stack cable runs through the plurality of pulleys whereby rotation of the pelvic belt relative to the stationary pelvic belt receiving frame causes the coupled weights to raise and lower.

US Pat. No. 10,188,900

EXTENSION BASE FOR EXERCISE APPARATUS

BH Asia Hong Kong Holding...

1. An extension base for an exercise apparatus, the exercise apparatus having a frame that carries a flywheel for providing loading, and two treadles connected to the flywheel from two sides through respective cranks, so that when the two treadles are treaded, the flywheel provides resistance, and the extension base comprising:a stationary seat, being attached to a bottom of the frame, and being of a tubular structure that has a channel and has openings at two ends of the channel; and
two extension legs, each having an appropriate length and being inserted into the channel from the two openings, respectively, so that the extension legs can be symmetrically extended and retracted with respect to the stationary seat, wherein when the extension legs are fully retracted into the stationary seat, a distance between outer ends of the two extension legs farthest away from each other is still long enough to support an elliptical exerciser and prevent the elliptical exerciser from falling, each of the extension legs has a slot in a segment thereof retractable into the channel, the slot extending in a direction parallel to a direction in which the extension leg moves, the stationary seat having two retaining portions corresponding to the slots of the extension legs, extension of the extension legs with respect to the stationary seat being limited by retaining portions moving in the slots, so as to prevent the extension legs from leaving the stationary seat.

US Pat. No. 10,188,899

DEADLIFT BAR APPARATUS AND METHOD

1. A deadlift device comprising:a base;
a vertically-oriented cylindrical shaft comprising:
a bottom end portion connected to the base,
a top end portion comprising a top edge,
an external diameter, and
a plurality of horizontal channels located between the top end portion and the bottom end portion, each horizontal channel comprising:
a main horizontally-oriented cylindrical through hole having a diameter with a bottom portion, and
a keyhole slot extending downwardly from the bottom portion, wherein the respective diameters of the plurality of horizontal channels are the same; and
a removable elongated lift bar assembly comprising:
an elongated lift bar comprising a first end and a second end, and
a locking element configured to secure the elongated lift bar into the main horizontally-oriented cylindrical through hole of a selected horizontal channel on the vertically-oriented cylindrical shaft.

US Pat. No. 10,188,896

EXERCISE ASSISTING DEVICE

1. An exercise assisting device comprising:a gripping member extending in a tubular shape or columnar shape that can be gripped by hand, and
a first plate-shaped weight member, and
a second plate-shaped weight member;
wherein the gripping member has a recessed part in which only a portion at which a middle finger is disposed upon gripping by hand is recessed,
wherein forward of the gripping member corresponds to forward of a person, and rearward of the gripping member corresponds to rearward of the person, when gripping the gripping member forward of the person in a state making the gripping member stand up,
wherein a first flat surface having a first weight mounting part is disposed at a lower part on a rearward side of the gripping member and the first plate-shaped weight member is configured to attach to the first weight mounting part, and
wherein a second flat surface having a second weight mounting part is disposed on the rearward side of the gripping member, and the second plate-shaped weight member is configured to attach to the second weight mounting part so that the second plate-shaped weight member extends in a longitudinal direction of the gripping member.

US Pat. No. 10,188,894

BARBELL

1. A barbell comprising:a grip unit including two frames spaced apart from each other along a first direction, and a grip rod connected between said frames and configured to be gripped by a user's hand;
a support unit including two support members that are connected between said frames, that are spaced apart from said grip rod along a second direction transverse to the first direction, and that are configured to abut against a user's forearm, said support members being spaced apart from each other along a third direction transverse to the first and second directions, each of said support members extending along the first direction; and
a carrier unit including two hanging rods extending outwardly and respectively from said frames and located between said grip rod and said support members;
wherein said hanging rods extend along the first direction and are arranged in a straight line, and said grip rod is spaced apart from said hanging rods along the second direction by a distance greater than or equal to a distance between said support members and said hanging rods along the second direction; and
wherein each of said frames includes a main rod, a tubular sleeve sleeved on said main rod and connected to a respective one of said hanging rods and one end of said grip rod, and a supporting rod connected to said main rod and extending along the third direction, said support members being connected between said supporting rods of said frames, said tubular sleeve being movable relative to said main rod along the second direction to change its position on said main rod, said grip unit further including a fixing mechanism to fix said tubular sleeves of said frames to said main rods of said frames, respectively.

US Pat. No. 10,188,893

HANDHELD WEIGHTED EXERCISING APPARATUS

Mitz Fitness Limited, Ch...

1. An exercise apparatus comprising:a housing configured to receive a hand of a user and extend, in use, up to a wrist area of the user, the housing comprising an upper surface, a lower surface and sides between the upper surface and the lower surface, wherein the housing incorporates a plurality of vents, the plurality of vents located on the upper and the lower surfaces of the housing;
an opening within the housing for receiving the hand of the user;
a handle inside the housing, wherein the handle is disposed within the housing closer to an end of the housing which opposes the opening than to the opening; and
at least one weight provided by, configured within or disposed in relation to the housing and/or the handle,
wherein at least 30% of the area of the upper and the lower surfaces of the housing is the plurality of vents,
whereby in use, the user grips the handle with the hand inside the housing, to lift the at least one weight to perform exercises with the exercise apparatus.

US Pat. No. 10,188,891

STEPPER MACHINE WITH ELASTIC RESISTANCE GENERATING COMPONENT

1. An exercise machine, comprising:a base frame adapted to be positioned on a support surface;
a pair of left and right pedal assemblies, each of which positioned over and rotatably supported by the base frame at a first end of the left and right pedal assemblies, the pedal assemblies having a pair of left and right pedals, and
a pedal supporting assembly attached to the base frame and configured to pivot around an axis and support the left and right pedal assemblies at a second end of each of the left and right pedal assemblies, the pedal supporting assembly comprising a resistance generating component, wherein the resistance generating component includes an elastic component operable to generate resistance in response to movement of the left and right pedals and the pedal supporting assembly pivoting around the axis.

US Pat. No. 10,188,887

AZEOTROPIC AND AZEOTROPE-LIKE COMPOSITIONS OF HFO-E-1,3,4,4,4-PENTAFLUORO-3-TRIFLUOROMETHYL-1-BUTENE AND USES THEREOF

THE CHEMOURS COMPANY FC, ...

1. A composition consisting essentially of:(a) HFO-E-1,3,4,4,4-pentafluoro-3-trifluoromethyl-1-butene; and
(b) HFO-E-1,1,1,4,4,4-hexafluoro-2-butene wherein the HFO-E-1,1,1,4,4,4-hexafluoro-2-butene is present in an effective amount to form an azeotropic composition with the HFO-E-1,3,4,4,4-pentafluoro-3-trifluoromethyl-1-butene.

US Pat. No. 10,188,886

VALVE MONITORING

Amtron Valve Monitoring D...

1. A valve gear box having a valve monitoring function, said valve gear box being for mounting to a valve that has a fluid passageway and a gate therefor, said gear box providing a gear driven link for moving said gate between open and closed conditions of said fluid passageway, said valve gear box being in a housing that has a mounting for permitting operative connection to the valve via a mounting flange of said valve,said mounting and said mounting flange having a valve monitoring sensor operatively positioned therewith, said sensor being settable in one state when said mounting and said mounting flange are in assembled relationship to each other but being configured to change from said one state if there is a separation of the fastened connection of the mounting and said mounting flange, whereby a change in state from said one state can be used to monitor a separation of the assembled relationship of said mounting and said mounting flange and trigger an alarm condition,
wherein said gear driven link has a gate position sensor associated therewith so that said gate position sensor can be in one state when the gate is in an opened condition, and which can change from said one state when said gate is moved towards a closed condition,
whereby a change of state from said one state can be used to monitor a closing of said gate and trigger an alarm condition.

US Pat. No. 10,188,882

COMPONENT FOR FITTING TO A SAFETY HARNESS

Marco Einhaus, Wessling ...

1. A component for being attachable to a safety harness for a human user for at least partially keeping free the femoral vein of the user, the component comprising:a carrier structure;
two leg harness pads attached to the carrier structure with such a distance to each other, that a leg harness pad-free portion of the carrier structure, which remains between the leg harness pads is configured to keep a femoral vein of the user at least partially free, in a state of the component attached to the safety harness, when the user has put on the safety harness; and
a detachable fixing mechanism which is attached or attachable to the carrier structure, for detachably fixing the component to the safety harness,
wherein the leg harness pads are formed wedge-shaped, such that respective front faces of the wedge-shaped leg harness pads are facing each other with the leg harness pad-free portion in between.

US Pat. No. 10,188,881

CONTAINER WITH COVER

14. A receptacle with at least one oxygen mask of an emergency oxygen supply device of an aircraft, the at least one oxygen mask being arranged in the receptacle, the receptacle comprising:an opening through which the at least one oxygen mask is configured to be led;
at least one cover for covering the opening, the at least one cover including at least a first cover section and a second cover section, the at least first cover section and the second cover section commonly fastened on the receptacle by a release device at a corner region at which the at least first cover section and second cover section overlap; and
the release device configured to be actuated by pull means, the release device configured to release the at least one cover.

US Pat. No. 10,188,875

TUMOR SURFACE DOSE ENHANCING RADIOTHERAPY APPARATUS USING MAGNETIC FIELD

THE ASAN FOUNDATION, Seo...

1. A tumor surface dose enhancing radiotherapy apparatus using a magnetic field, comprising:a radiation beam generating unit that irradiates a radiation beam towards a tumor of a patient;
a magnetic field generating unit that forms a magnetic field area that is parallel to the radiation beam between the radiation beam generating unit and the tumor of the patient; and
a control unit that controls a surface dose of the tumor by adjusting an intensity and an effective area of the magnetic field area of the magnetic field generating unit,
wherein the control unit further comprises a calculation unit that calculates the surface dose of the tumor that is delivered to the tumor of the patient via the magnetic field area.

US Pat. No. 10,188,873

SYSTEMS AND METHODS FOR DOSE CALCULATION IN GENERATING RADIATION TREATMENT PLANS

Varian Medical Systems In...

1. A computing system comprising:a central processing unit (CPU); and
memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations associated with generating a radiation treatment plan, the operations comprising:
accessing a first dose calculated using first set of fluence maps and a first dose prediction model;
accessing a second fluence map;
projecting the second fluence map onto the first set of fluence maps to determine a set of scalars and a residual value; and
when the residual value satisfies a criterion, calculating a second dose using the first dose prediction model, the set of scalars, and the second fluence map, and wherein when the residual value does not satisfy the criterion, calculating the second dose using a second dose prediction model and the second fluence map.

US Pat. No. 10,188,871

FLAT OPTOGENETIC CUFF INTERFACE (FOCI) FOR A SINGLE NERVE FASCICLE OF THE PERIPHERAL NERVOUS SYSTEM

1. A flat optogenetic cuff interface (FOCI) for functional optical stimulation of axons in a single fascicle of a human peripheral nerve, wherein said axons have been genetically modified to express light sensitive proteins for excitation or inhibition of the nerves, said system comprising:a cuff configured for a single human nerve fascicle having an external configuration with a cross-section height Y and a cross-section width X, the cuff comprising an elastic collar member defining an internal opening which has an internal configuration having an initial cross-section height between 0.4 mm and 1.0 mm and a reshaped cross-section height between 0.2 mm and 0.5 mm and a width greater than X, said collar member including a material that exerts a force on said nerve fascicle that will cause the fascicle to gradually reshape to the internal configuration of said opening with a cross-section height between 0.2 mm and 0.5 mm with a change in cross-section height limited to a maximum of 2×, said gradual reshaping of the fascicle reorganizing the axons within the fascicle without reshaping the individual axons;
an optical interface comprising a plurality of optical sources arranged in two-dimensional arrays on opposing sides of the cuff, each said optical source configured to illuminate a length of the nerve of at least 50 microns and less than 10% of the cross-section of the reshaped nerve fascicle, said optical sources configured to emit pulsed light at a pulse repetition frequency (PRF) to penetrate the reshaped nerve fascicle from opposing sides at a power level such that the irradiance incident upon tissue at the PRF throughout the reshaped nerve fascicle is less than a Maximum Permissible Exposure (MPE) to selectively irradiate and stimulate all of the axons in the single fascicle over an entire cross-section of the reshaped nerve fascicle along a length of the nerve of at least 2 mm at a level greater than a Minimum Source Power (MSP) to stimulate axons; and
an electrical interface comprising a plurality of electrodes across the width of the cuff configured to sense activity of axons within the fascicle.

US Pat. No. 10,188,870

SYSTEM AND METHOD FOR OPTOGENETIC THERAPY

Circuit Therapeutics, Inc...

1. A system for injecting a targeted tissue structure, comprising: an elongate flexible injection member biased to assume an arcuate geometric configuration when unloaded, the injection member comprising a matrix of injection needles and being configured to assume a substantially straight geometric configuration based upon a remote manipulation input from an operator, wherein the unloaded arcuate geometry is configured to approximate an arcuate outer surface of the targeted tissue structure; and an elongate delivery conduit defining a lumen through which the elongate flexible injection member is configured to be movably coupled.

US Pat. No. 10,188,869

HARDWARE/SOFTWARE INTEGRATED DESIGN FOR A 3D TREMOR DETECTOR USING TMS IN PARKINSON'S DISEASE AND RELATED DISORDERS

The Florida International...

1. A system comprising:a Transcranial Magnetic Stimulation (TMS) machine;
a Transcranial Stimulation Biofeedback (TSB) Detector device;
a software component comprising instructions stored on one or more non-transitory computer readable media that, when executed by a computing device, direct the computing device to:
receive waveforms from the TSB Detector device;
compute a determination factor based on the waveforms; and
when the determination factor is outside a predetermined range, send an abort signal such that the TMS machine ceases providing magnetic stimulation, and when the determination factor is not outside the predetermined range, allow the TMS machine to continue providing magnetic stimulation,
the TSB Detector device comprising:
a three-axis accelerometer sensor configured to provide three-dimensional signals;
a three-channel analog amplifier configured to receive the three-dimensional signals; and
a capacitor and a resistor connected between the three-axis accelerometer and the three-channel analog amplifier and configured to generate a cut-off frequency, and
three-dimensional tremor signals detected by the TSB Detector device being synchronized with the TMS machine via a dual communication link.

US Pat. No. 10,188,867

METHOD AND APPARATUS FOR BEAT ACQUISITION DURING TEMPLATE GENERATION IN A MEDICAL DEVICE HAVING DUAL SENSING VECTORS

Medtronic, Inc., Minneap...

1. A medical device for generating a template, comprising:a plurality of electrodes configured to sense a cardiac signal;
a storage device comprising a plurality of subgroups for storing beats; and
a processor configured to:
identify a plurality of beats in the sensed cardiac signal,
determine that a first beat of the plurality of beats is an initial beat to be stored in the first subgroup of the plurality of subgroups,
set the first beat as a first subgroup template beat in response to the first beat being the initial beat,
determine, for each remaining beat of the plurality of beats, whether to store the beat within a subgroup of the plurality of subgroups of the storage device,
determine whether a number of beats stored in one of the plurality of subgroups exceeds a subgroup threshold, and in response to the number of beats stored in the one of the plurality of subgroups exceeding the subgroup threshold, and
generate a template beat using one or more beats of the one of the plurality of subgroups that exceeds the subgroup threshold.

US Pat. No. 10,188,866

SIMPLE CONTROL OF COMPLEX BIO-IMPLANTS

Impulse Dynamics NV, Wil...

1. A method of adjusting the operation of an implantable medical device, comprising:receiving access to selectively activate from among a plurality of technical parameter sets preconfigured for use with the implantable medical device, wherein the parameter sets are ordered according to their effect on a clinical parameter affected by operation of the device;
monitoring the response of the clinical parameter to activation of a first of the preconfigured parameter sets ordered between at least two others of the preconfigured parameter sets; and
activating one of the other two preconfigured parameter sets, based on the ordering of the parameter sets, the monitoring of the clinical parameter and a clinical target for the clinical parameter.

US Pat. No. 10,188,865

SYSTEMS AND METHODS OF COMBINED TONIC DBS AND RANDOM DBS

PACESETTER, INC., Sylmar...

1. A method of applying a combination of tonic stimulation and random stimulation using a deep brain stimulation (DBS) lead including a plurality of contacts to treat Parkinson's Disease (PD) in a patient, the method comprising:reducing PD-related tremor in the patient by delivering tonic stimulation using one contact of the plurality of contacts, wherein the tonic stimulation comprises a plurality of pulses with pulse parameters selected to reduce PD-related tremor in the patient; and
reducing PD-related rigidity and bradykinesia in the patient by delivering random stimulation using a subset of the remaining contacts of the plurality of contacts, wherein the random stimulation is delivered using respective bursts of multiple pulses applied to randomly or pseudo-randomly selected contacts of the subset and wherein the random stimulation comprises pulses with pulse parameters selected to reduce PD-related rigidity and bradykinesia.

US Pat. No. 10,188,864

SYSTEMS AND METHODS FOR TISSUE STIMULATION IN MEDICAL TREATMENT

1. A neurostimulation system, comprising:at least one electrical lead configured for being implanted in a patient and coupled to a plurality of electrical contacts;
a control subsystem having control circuitry configured for:
controlling a stimulation subsystem having stimulation circuitry for generating a plurality of individual partial signals which are electrical pulse trains at one or more pulse rates, and the control circuitry is configured for instructing a modulation output circuitry to repeatedly generate the plurality of individual electrical pulse trains that result in a vector field having a bursting pattern;
routing the pulse trains from the stimulation circuitry to the plurality of electrical contacts; and,
concurrently conveying each of the plurality of electrical pulse trains respectively to at least one of the plurality of electrical contacts in a manner that allows a combined vector electrical pulse train to be characterized by a pulse rate for at least a portion of the vector electrical pulse train that is equal to or greater than twice the frequency of the individual pulse trains,
wherein at least one electrical pulse train has a frequency of between 1 kHz and 100 kHz.

US Pat. No. 10,188,863

THERAPY PROGRAM SELECTION FOR ELECTRICAL STIMULATION THERAPY BASED ON A VOLUME OF TISSUE ACTIVATION

Medtronic, Inc., Minneap...

1. A method comprising:determining, by one or more processors, values for one or more voxels of a plurality of voxels of a three-dimensional grid, wherein determining the values comprises:
determining a volume of tissue activation (VTA) expected to result from delivery of electrical stimulation by a medical device according to a therapy program of a plurality of therapy programs;
registering the VTA to the three-dimensional grid;
obtaining a bioelectrical brain signal of a patient sensed during delivery of the electrical stimulation to the patient by the medical device according to the therapy program;
determining a frequency domain characteristic of the bioelectrical brain signal; and
determining a value for at least one of the voxels overlapping with the VTA based on the frequency domain characteristic of the bioelectrical brain signal;
evaluating, by the one or more processors and based on the values of the voxels of the three-dimensional grid, therapy programs of the plurality of therapy programs for use in delivering subsequent electrical stimulation to the patient; and
controlling, based on the evaluations of the therapy programs, delivery of the subsequent electrical stimulation to the patient.

US Pat. No. 10,188,862

METHODS AND SYSTEMS FOR CONTROLLING A STATE OF A NEUROSTIMULATOR

NeuroPace, Inc., Mountai...

1. An active implantable medical device comprising:a sensor for detecting a presence of a magnetic field;
a timer configured to keep track of the amount of time the sensor detects the magnetic field uninterrupted;
a magnet tracking subsystem including a magnet tracking software object configured to exist in one of a plurality of software object states, and to transition to and from software object states based on one or more of a detection of a magnetic field, a duration of a detection of a magnetic field, and a state of the timer; and
an interface for passing messages and information from the magnet tracking software object to at least one other software object that controls the state of the active implantable medical device, which state is one of a plurality of states comprising a first medical device activity state or a second, different medical device activity state,
wherein the magnet tracking subsystem is configured to:
monitor a number of times the state of the active implantable medical device has transitioned from a designated one of the plurality of states to another one of the plurality of states within a period of time, and
prevent the state of the active implantable medical device from transitioning from the designated one of the plurality of states to the other one of the plurality of states when the number of times exceeds a threshold value.

US Pat. No. 10,188,861

BIOABSORBABLE OR PARTIALLY-BIOABSORBABLE BONE GROWTH STIMULATOR SYSTEM AND METHOD FOR MANUFACTURING A BIOABSORBABLE OR PARTIALLY-BIOABSORBABLE BONE-REGENERATION STIMULATOR SYSTEM

Warsaw Orthopedic, Inc., ...

1. A bone growth stimulator system for use in bone regeneration therapy, the system comprising:a bioabsorbable capsule defining an interior cavity, the capsule having a selected capsule thickness, and a known dissolution time;
bioabsorbable electric circuitry disposed within the interior cavity of the bioabsorble capsule for outputting a bone growth stimulation current, the bioabsorbable electric circuitry including an anode, a cathode, an ammeter, a voltmeter, and an operational amplifier, and at least the ammeter, the voltmeter, and the operational amplifier are made of one of bioabsorbable magnesium and bioabsorbable magnesium oxide; and
one of a bioabsorbable battery and a biocompatible battery for supplying power to the electric circuitry via an electrical coupling;
wherein the known dissolution time of the capsule is directly proportional to the selected capsule thickness;
wherein the selected capsule thickness is selected to bring about dissolution of at least the capsule and the electric circuitry following completion of the bone regeneration therapy; and
wherein: the voltmeter measures voltage in the electric circuitry adjacent the operational amplifier, the operational amplifier receives a first voltage input corresponding to voltage supplied by the one of the bioabsorbable battery and the biocompatible battery, and receives a second voltage input corresponding to voltage outputted by the operational amplifier, the operational amplifier is configured to maintain current to be constant and non-fluctuating in the electric circuitry, and the bone growth stimulation current is applied via the anode and the cathode.

US Pat. No. 10,188,860

SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE

NeuroPace, Inc., Mountai...

1. A system for introducing a form of neuromodulation to a patient, the system comprising:at least one transcranial channel configured to be implanted in an aperture in the skull of the patient, and comprising an outer wall defining an interior cavity, and an ion-permeable substance at least partially filling the interior cavity, the ion-permeable substance configured to facilitate conduction of the form of neuromodulation;
at least one scalp electrode pad comprising an orienting feature configured to engage an ear of the patient to thereby position the at least one scalp electrode pad in a vicinity of the at least one transcranial channel near a target area of neural tissue;
a stimulation source electrically coupled to the at least one scalp electrode pad and configured to generate the form of neuromodulation and deliver the form of neuromodulation to the patient through the at least one scalp electrode pad and the at least one transcranial channel; and
a securing feature coupled to the at least one scalp electrode pad and configured to secure the at least one scalp electrode pad at the vicinity of the at least one transcranial channel.

US Pat. No. 10,188,859

PORTABLE ONE-PIECE THERAPEUTICAL APPARATUS WITH DUAL HEATING AND LOW-FREQUENCY TREATMENT FUNCTIONS

HIVOX BIOTEK INC., New T...

1. A portable one-piece therapeutical apparatus with dual heating and low-frequency treatment functions, comprising:a main unit, being in a one-piece injection molded form and including a main body portion and a patch portion extended separately and outwardly from both sides of the main body portion, and the main body portion having an accommodating unit, and the accommodating unit having an accommodating space;
a control means, installed in the accommodating space, and including a printed circuit board assembly, having an operating component installed on the printed circuit board assembly for controlling heating low-frequency pulses;
two heating means, each heating means is in the position of a middle layer of each patch portion, and each heating means has a heating plate, and each heating plate has a printed silver paste heating circuit pattern, and the heating circuit pattern includes an electrical contact terminal electrically coupled to the printed circuit board assembly for producing a heating effect, and a diffuser is attached to the top of the heating circuit pattern, wherein the diffuser is provided for diffusing the heat generated by the heating circuit pattern and preventing the heat from being concentrated at a position to facilitate the heating operation;
two low-frequency electrode layers, each low-frequency electrode layer disposed under each heating means and includes a base layer made of a PET material; two low-frequency circuit patterns, each low-frequency circuit pattern installed under the base layer, and including a low-frequency circuit contact terminal coupled to the printed circuit board assembly and a middle portion disposed at the middle portion of the low-frequency circuit pattern, and the low-frequency circuit contact terminal being electrically coupled to the printed circuit board assembly, wherein the low-frequency circuit pattern under the base layer is printed to form a conducting circuit; two distribution layers, disposed under each low-frequency circuit pattern, wherein the distribution layer under the low-frequency circuit pattern and the base layer is formed by an insulated oil printing process, and the purpose of the distribution layer is to prevent any unnecessary electrode output in order to distribute current uniformly, the bottom of the distribution layer further has a carbon ink layer attached and configured to contact skin for performing a low frequency output of the low-frequency electrode layer;
a battery, installed in the accommodating space, and directly and electrically coupled to the printed circuit board assembly for supplying power to the therapeutical apparatus.

US Pat. No. 10,188,857

LEAD IDENTIFICATION SYSTEM

Nuvectra Corporation, Pl...

1. A method, comprising:inserting an epidural needle into a patient, the epidural needle having a stylet;
removing the stylet from the epidural needle;
inserting an implantable lead through the epidural needle, the implantable lead having a plurality of contacts;
positioning the implantable lead; and
attaching a removable lead indicator to the epidural needle.

US Pat. No. 10,188,854

MICROELECTRODE AND MULTIPLE MICROELECTRODES

NEURONANO AB, (SE)

1. An array of medical microelectrodes comprising at least two medical microelectrodes, each medical microelectrode of the at least two medical microelectrodes is configured for insertion into soft tissue, each medical microelectrode comprising:an electrically conducting elongate electrode body including a first proximal end, and a second distal end, the electrode body comprising:
a tip section extending from the distal end;
a main body section extending in a proximal direction from the tip section,
wherein the tip section and the main body section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid;
a dissolution retarding layer on the first electrode matrix element; and
a second electrode matrix section element, different from the first electrode matrix section element, the second electrode matrix section element positioned such that the first electrode matrix section element is positioned between the second electrode matrix section element and the electrode main body,
wherein at least one the first electrode matrix element and the second electrode matrix element comprises a drug configured to be released upon dissolution or biodegradation of the first electrode matrix element, and
wherein the at least two microelectrodes are positioned interspaced on a face of a solid support.

US Pat. No. 10,188,853

FLEXIBLE CIRCUIT ELECTRODE ARRAY WITH A DRUM STRESS RELIEF

Second Sight Medical Prod...

1. A flexible circuit electrode array comprising:a polymer base layer, comprised of a first hard polymer, configured to support traces;
metal traces deposited on said polymer base layer, including electrodes configured to stimulate neural tissue;
a polymer top layer deposited on said polymer base layer and said metal traces, said polymer top layer defining electrode voids to expose the electrodes, wherein the polymer base layer, metal traces, and polymer top layer form a flexible circuit and include an attachment point void through both the polymer base layer and polymer top layer that is separate from said electrode voids; and
a soft polymer membrane configured to be penetrated by a retinal tack, wherein the soft polymer membrane is adhered to the flexible circuit below a surface area configured to be closest to a retina and across the attachment point void, the soft polymer membrane being softer than the hard polymer.

US Pat. No. 10,188,851

TTFIELD TREATMENT WITH OPTIMIZATION OF ELECTRODE POSITIONS ON THE HEAD BASED ON MRI-BASED CONDUCTIVITY MEASUREMENTS

NOVOCURE LIMITED, St. He...

1. A method of optimizing positions of a plurality of electrodes placed on a subject's body, wherein the electrodes are used to impose an electric field in target tissue within an anatomic volume, the method comprising the steps of:obtaining electrical conductivity or resistivity measurements in the anatomic volume;
generating a 3D map of electrical conductivity or resistivity of the anatomic volume directly from the obtained electrical conductivity or resistivity measurements, without segmenting the anatomic volume into tissue types;
identifying a location of the target tissue within the anatomic volume; and
determining positions for the electrodes based on the 3D map of electrical conductivity or resistivity generated in the generating step and the location of the target tissue identified in the identifying step.

US Pat. No. 10,188,850

FLUID LEVEL MONITORING DEVICE

FIVAMED INC., Halifax (C...

1. A method for monitoring and/or controlling delivery of a fluid to a patient through a flexible fluid delivery tube, the method comprising:providing a fluid-flow monitoring and/or control device removeably mountable to a fluid delivery system configured to deliver the fluid to the patient, the fluid delivery system including the flexible fluid delivery tube, the fluid-flow control device including a fluid level sensing mechanism;
using the fluid level sensing mechanism to detect that a fluid level of the fluid supplied through the flexible delivery tube has dropped below a predetermined level; and
in response to the detection of the fluid level dropping below the predetermined level:
generating an alarm indicating that the fluid level has dropped below the predetermined level; and
reconfiguring a flow control mechanism from a first configuration in which flow of the fluid through the fluid delivery system is not blocked to a second configuration in which the flow of the fluid through the fluid delivery system is blocked by a portion of the flow control mechanism that is moved to interface with the fluid delivery system by:
configuring a trigger that is operatively coupled with the flow control mechanism in an actuated configuration in which the flow control mechanism is in the first configuration;
engaging a latching mechanism with a trigger to retain the trigger in the actuated configuration prior to the detection of the fluid level dropping below the predetermined level; and
inducing a length change in a shape memory wire that is operatively coupled with the latching mechanism so as to disengage the latching mechanism from the trigger and move the trigger from the actuated configuration to a non-actuated configuration which reconfigures the flow control mechanism from the first configuration to the second configuration in response to the detection of the fluid level dropping below the predetermined level.

US Pat. No. 10,188,849

SYSTEMS, METHODS, AND COMPONENTS FOR TRANSFERRING MEDICAL FLUIDS

ICU Medical, Inc., San C...

1. An electronic medical fluid transfer device comprising:one or more supports configured to receive a fluid transfer module comprising a first inlet fluid connector, a second outlet fluid connector, a multidirectional flow control valve, and an intermediate container or pumping region;
a gas sensor configured to detect whether gas is present in the fluid transfer module;
a first electromechanical driver configured to interface with and control the multidirectional flow control valve on the fluid transfer module;
a second electromechanical driver configured to be mechanically linked to the intermediate container or pumping region;
a computer processor or processors configured to communicate electronically with the sensor and the first and second electromechanical drivers to prime or purge the fluid transfer module with liquid before use and to purge gas from the fluid transfer module during use.

US Pat. No. 10,188,846

TWO-WAY RETRACTABLE MEDICAL TUBING REEL

1. A two-way retractable medical tubing reel system comprising:a housing comprising an interior, an exterior, a top, a bottom, a proximal aperture and a distal aperture;
a generally cylindrical reel rotatably mounted in the housing interior and having a reel wall comprising an outer surface having an outer surface circumference, an inner surface having an inner surface circumference, a first wall aperture and a second wall aperture, the reel wall separating a reel exterior from a reel interior;
a spindle located in the housing interior;
a generally cylindrical spring container located in the reel interior, the spring container comprising a spring attached to the spindle;
a track attached to the reel wall and comprising a first end, a U-shaped segment, an internal segment, a second end, and a track length extending from the first end to the second end, wherein the internal segment extends from the first wall aperture to the second wall aperture and is located between the spring container and the inner surface of the reel wall;
a sterile generally hollow tube located in the track and extending along the track length, the sterile generally hollow tube also wrapped around the outer surface circumference, the track comprising a proximal end configured to connect to a patient, a distal end configured to connect to an intravenous (IV) fluid bag, and a tube length extending from the proximal end to the distal end, the generally hollow tube passing through the proximal and distal apertures;
the generally hollow tube having an extended position wherein a segment of the generally hollow tube is fully enclosed in the housing;
the generally hollow tube having a retracted position wherein a longer segment of the tube is fully enclosed in the housing as compared to the extended position and wherein the generally hollow tube wraps around the outer surface circumference a greater number of times as compared to the extended position;
wherein the spring is configured to bias the generally hollow tube in the retracted position;
wherein pulling on the proximal end and the distal end of the generally hollow tube in the retracted position is configured to cause the generally cylindrical reel to rotate relative to the housing and move the generally hollow tube to the extended position.

US Pat. No. 10,188,845

HEMOSTASIS VALVE ASSEMBLY

St. Jude Medical, Cardiol...

1. A hemostasis valve assembly, comprising:a housing; and
a valve member positioned within the housing, the valve member comprising:
opposed first and second primary surfaces and a valve thickness defined between the first and second primary surfaces;
an opening formed in the first primary surface;
first and second slits arranged intersecting each other in an axial direction along a central axis, wherein the central axis extends from the first primary surface to the second primary surface, the first and second slits extending through a portion of the valve thickness, the first slit accessible within the opening and extending from the opening through the valve thickness to a depth within the valve located a distance from the second primary surface, and the second slit accessible from the second primary surface and extending from the second primary surface through the valve thickness to a depth within the valve located a distance from a bottom surface of the opening; and
a recess positioned between the opening and the first and second slits, wherein the opening has a first diameter and the recess has a second diameter, the first diameter being smaller than the second diameter.

US Pat. No. 10,188,844

ACCESS PORT LOCATOR

Primo Medical Group, Inc....

1. A medical device comprising:an access port locater configured to locate a subcutaneous access port located beneath a skin surface of a host, the access port locator including
at least one annular ring forming an aperture, the at least one annular ring having a longitudinal ring length disposed between first and second opposing ends and a longitudinal axis extending along the longitudinal ring length, the at least one annular ring positionable on the skin surface of the host with the first end of the at least one annular ring in contact with the skin surface and the longitudinal axis of the at least one annular ring substantially perpendicular to the skin surface;
at least one stabilizing flange configured to stabilize the access port locater on the skin surface, the at least one stabilizing flange extending laterally from the longitudinal ring length of the at least one annular ring;
at least one needle guard configured to shield a hand of a user of the access port locator when the hand is positioned on the stabilizing flange;
a first end region at the first end of the at least one annular ring forms an annular protrusion relative to the at least one stabilizing flange which is arranged to provide a pressure concentration ridge to press into the skin surface; and
the annular protrusion disposed adjacent the aperture.

US Pat. No. 10,188,843

ULTRASOUND AND MICROBUBBLES IN OCULAR DIAGNOSTICS AND THERAPIES

UNIVERSITY OF SOUTHERN CA...

1. A method of treating a retinal blood vessel blockage of a patient, the method comprising:applying first ultrasound energy generated by an ultrasound probe to locate an area of blockage within a retinal blood vessel;
directing gas-filled microbubbles to the area of blockage within the retinal blood vessel, wherein the microbubbles are not loaded with a therapeutic agent; and
breaking up clots that are causing blockage at said area of blockage by delivering second ultrasound energy generated by the ultrasound probe to the area of blockage, wherein the delivering causes the microbubbles to activate or rupture.

US Pat. No. 10,188,842

APPARATUS AND METHOD FOR DEPLOYING A SURGICAL PREPARATION

1. A containment device for deploying an antiseptic preparation to an extremity of a patient comprising:a flexible container, comprised of a first portion and a second portion, configured to surround the extremity;
a fastening means, for the separable and resealable attachment of the first portion to the second portion, attached to the flexible container;
a sealing means, fused to the flexible container, capable of securing a seal between the extremity and an exterior of the flexible container;
a sealable opening in the flexible container for introduction of the antiseptic preparation; and,
whereby the antiseptic preparation is deployed into and contained within the flexible container.

US Pat. No. 10,188,840

COMPUTERIZED ORAL PRESCRIPTION ADMINISTRATION DEVICES AND ASSOCIATED SYSTEMS AND METHODS

Berkshire Biomedical, LLC...

1. A method of assembling a substance dispensing device, the method comprising:coupling a sensing element to a mouthpiece including a recess sized and shaped to receive an intended user's unique dentition, the sensing element configured to determine if the intended user's unique dentition is positioned within the recess of the mouthpiece based on a comparison to data associated with the intended user's unique dentition being positioned within the recess; and
coupling a substance dispensing unit to the mouthpiece, wherein the substance dispensing unit is in communication with the sensing element and is configured to dispense a substance to the intended user in response to the sensing element determining that the intended user's unique dentition is positioned within the recess.

US Pat. No. 10,188,839

SYSTEMS AND METHOD FOR BYPASSING AN ANASTOMOSIS SITE

Colospan Ltd., Kfar-Saba...

1. An apparatus for delivery of a device into a hollow organ comprising:(a) an elongated tube having proximal and distal openings and being configured for carrying the device on a distal portion thereof; and
(b) a tubular net structure for covering said distal portion of said elongated tube, said tubular net structure being at least partially covered by, and separate from, an elastic constraining tube, said tubular net structure and said elastic constraining tube being retrievable into said elongated tube through said distal opening such that when the device is mounted on said distal portion and covered by said tubular net structure and said tubular net structure is partially covered and constrained by said elastic constraining tube, retrieval of said tubular net structure and said elastic constraining tube into said elongated tube uncovers the device for delivery into the hollow organ, wherein said tubular net structure is configured for reducing friction between said elastic constraining tube and the device thereby facilitating uncovering of the device.

US Pat. No. 10,188,836

FOLDING INSERTER FOR DRUG DELIVERY INFUSION SET

Becton, Dickinson and Com...

1. An infusion set, comprising:a base; and
an inserter pivotally connected to said base, said inserter including:
a catheter movable from a first catheter position to a second catheter position;
an introducer needle located within said catheter and movable between a first introducer needle position and a second introducer needle position; and
an activation button movable between first and second button positions, wherein when said activation button is moved from said first button position to said second button position, said catheter is moved from said first toward said second catheter position, said introducer needle is moved from said first toward said second introducer needle position to facilitate insertion of said catheter, and said introducer needle is thereafter moved back toward said first introducer needle position to store said introducer needle within said inserter with a free end of said catheter remaining disposed externally of said inserter and said base;
wherein in the first button position, the inserter is not configured to fold substantially entirely within said base in the first inserter position, and in the second button position, the inserter is configured to fold substantially entirely within said base in the second inserter position.

US Pat. No. 10,188,833

GUIDE CATHETER WITH STEERING MECHANISMS

Medtronic Vascular, Inc.,...

1. An endovascular guide catheter comprising:a flexible guide tube having a distal end portion configured to deflect via actuation of a pull wire; and
a handle coupled to the guide tube and comprising a steering assembly configured to actuate the pull wire to deflect the distal end portion of the guide tube, the steering assembly comprising:
a stationary rack;
a gear engaging the rack;
a reel coupled to and configured to rotate with the gear, the pull wire being coupled to the reel such that rotation of the reel causes the pull wire to wind or unwind around the reel;
a slider adapted for translation relative to the rack, wherein translation of the slider translates the reel relative to the rack and rotation of the gear along the rack rotates the reel; and
an actuator disposed at a distal end of the handle, the actuator is configured to rotate about a longitudinal axis of the guide catheter to drive the translation of the slider relative to the rack, wherein the actuator is externally disposed about and coupled to a threaded rod, and wherein the threaded rod is configured for translational movement and is coupled to the slider at a proximal end portion.

US Pat. No. 10,188,832

STEERABLE DELIVERY SHEATHS

Shifamed Holdings, LLC, ...

1. A steerable medical delivery device, comprising:a steerable portion comprising
a first tubular member comprising a flexible polymeric tubular member that comprises a wall of solid material along the steerable portion, the first tubular member configured to preferentially bend, and
a second tubular member, wherein one of the first and second tubular members is disposed within the other, wherein the first and second tubular members are permanently axially fixed relative to one another at a fixation location distal to the steerable portion; and
an external controller with an actuator that is adapted to be actuated, the actuator and the first and second tubular members operably coupled such that actuation of the actuator puts one of the first tubular member and the second tubular member in tension and the other of the first tubular member and the second tubular member in compression, and wherein the first and second tubular members are adapted such that the steerable portion is steered in a first direction when the actuator is actuated.

US Pat. No. 10,188,830

VACUUM TREATMENT ARRAY AND FILM FOR PRODUCING A VACUUM TREATMENT ARRAY

1. A negative pressure treatment arrangement comprising:a flexible, negative pressure-stable, drainage tube forming at least one channel-shaped lumen;
at least one open-cell fluid-collecting element through which a negative pressure is capable of being generated in a body cavity and fluids and gases are capable of being collected, the fluid-collecting element having, at least in part, an outer boundary area and an inner boundary area that encircle a tubular axis and;
wherein the fluid-collecting element is connected to the drainage tube such that the fluid-collecting element is in fluid communication with the channel-shaped lumen of the drainage tube; and
wherein the fluid-collecting element and the drainage tube are structurally interconnected such that the outer boundary of the fluid-collecting element and the drainage tube have the same diameter and continuously merge into each other such that no part of the drainage tube extends into the fluid-collecting element.

US Pat. No. 10,188,829

CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

Medtronic Ardian Luxembou...

1. A method for treating a human patient, the method comprising:advancing a neuromodulation element of a neuromodulation catheter along a transradial approach to a target site within a renal artery of the patient, wherein the neuromodulation element is at a distal end portion of a shaft of the neuromodulation catheter, and wherein the shaft includes two or more first cut shapes and two or more second cut shapes interspersed along a helical path extending about a longitudinal axis of the shaft;
applying torsion to the shaft about the longitudinal axis while advancing the neuromodulation element, wherein the first cut shapes, to a greater extent than the second cut shapes, resist deformation of the shaft in response to the torsion;
operating the neuromodulation element to modulate one or more nerves proximate a wall of the renal artery;
withdrawing the neuromodulation element along the transradial approach after operating the neuromodulation element; and
applying tension to the shaft along the longitudinal axis while withdrawing the neuromodulation element, wherein the second cut shapes, to a greater extent than the first cut shapes, resist deformation of the shaft in response to the tension.

US Pat. No. 10,188,828

MEDICAL DEVICES, METHODS, AND KITS FOR DELIVERING MEDICATION TO A BODILY PASSAGE

Cook Medical Technologies...

1. A medical device for treating a sinus cavity, the medical device comprising:a cannula defining a cannula lumen extending between a first cannula opening and a second cannula opening;
a catheter having at least a portion disposed in the cannula lumen, the catheter having a catheter proximal end, a catheter distal end, a catheter length extending between the catheter proximal end and the catheter distal end, and defining a first catheter opening, a second catheter opening, a first bend, a coil, and a catheter lumen extending between the first catheter opening and the second catheter opening;
a coating disposed on the catheter; and
a pusher having a pusher proximal end and a pusher distal end slidably disposed in the cannula lumen and adapted to engage with the catheter proximal end to transfer axial movement to the catheter;
wherein the catheter is adapted to move between a first configuration in which the portion of the catheter disposed within the cannula lumen is substantially straight when disposed in the cannula lumen and a second configuration in which the catheter defines the first bend and the coil along the catheter length when the catheter is free of the cannula lumen.

US Pat. No. 10,188,827

DISTAL CLOSING CATHETERS AND METHODS FOR SAME

Uropharma Limited, Mount...

1. A urinary catheter for insertion into a urinary bladder of a subject, comprising:a drainage tube extending from a drainage opening adjacent a distal end of the catheter to a drainage outlet adjacent a proximal end of the catheter, wherein the proximal end of the catheter is configured for positioning outside the subject with the distal end of the catheter within the subject;
a closure member located adjacent the distal end of the catheter and movable within said drainage tube between an open position and a closed position:
in the open position said drainage opening is aligned with an aperture of the closure member, and
in the closed position the drainage opening is misaligned with the aperture of the closure member and the drainage tube is closed adjacent to the distal end of the catheter;
an actuator coupled with the closure member and operable from the proximal end of the catheter, the actuator configured to remotely move said closure member adjacent the distal end between said open and closed positions; and
an instillation lumen extending from an instillation port adjacent the proximal end of the catheter to an instillation outlet adjacent the distal end of the catheter, the instillation outlet is configured to discharge into the urinary bladder, wherein the instillation lumen is isolated from the drainage tube and the closure member.

US Pat. No. 10,188,826

CATHETERS INCLUDING ANTIMICROBIAL SLEEVE AND METHODS OF MAKING CATHETERS

Covidien LP, Mansfield, ...

1. A catheter, comprising:a tubular body having an outer surface;
a hub disposed on the outer surface of the tubular body;
a tissue in-growth cuff disposed on the outer surface of the tubular body distal to the hub; and
a sleeve disposed on only a portion of the outer surface of the tubular body between the hub and the cuff, the sleeve comprising an outer layer co-extruded on an inner layer, the catheter comprising a water-soluble, anti-microbial agent contained only in the outer layer of the sleeve,
wherein the inner layer has a thickness at least about three times the thickness of the outer layer to reduce swelling of the sleeve and anchor the outer layer.

US Pat. No. 10,188,825

HUMIDIFIER FOR A RESPIRATORY ASSISTANCE DEVICE, A RESPIRATORY ASSISTANCE DEVICE AND RELATED METHODS AND APPARATUS

1. A humidifier for a respiratory assistance device, the humidifier comprising:a chamber configured to contain liquid to be evaporated,
a metallic or carbon-based material configured to be in contact with the liquid,
a mixer or agitator,
an electric or magnetic field generator configured to generate an electric or magnetic field inside the chamber so as to control movement or positioning or speed of the metallic or carbon-based material,
wherein the humidifier is configured such that, in use, at least a portion of an inside of the chamber is exposed to light such that light impinges on the metallic or carbon-based material to generate localised heating of liquid molecules around the metallic or carbon-based material and generate vapour for use by the respiratory assistance device.

US Pat. No. 10,188,824

AEROSTASIS IN PULMONARY SURGERY

THE ARIZONA BOARD OF REGE...

1. A method for preventing air leaks from a serosal tissue wound, comprising:providing a device comprising a dispensing apparatus and a delivery apparatus in fluid communication with said dispensing apparatus;
rapidly warming frozen aliquots of fibrinogen and thrombin from about 0° C. to about 37° C. in about 3 minutes or less;
after fibrinogen aliquots and thrombin aliquots are rapidly warmed to about 37° C., the fibrinogen and thrombin aliquots are provided within about 5 minutes from said dispensing apparatus to said delivery apparatus;
mixing a fibrinogen stream and a thrombin stream in a pressurized gas stream, said pressurized gas stream having a pressure of 50 psi or greater;
generating a fibrin-forming foam; and
directing said fibrin-forming foam onto said serosal tissue wound.

US Pat. No. 10,188,823

CONTINUOUS HIGH PRESSURE DELIVERY SYSTEM

Philip Morris USA Inc., ...

1. A drug delivery system, comprising:an aerosol generator unit comprising (i) a capillary passage adapted to at least partially volatilize a liquid formulation, the capillary passage having a capillary passage inlet and a capillary passage outlet, (ii) a first heater body operable to heat the capillary passage to a temperature range effective to at least partially volatilize the liquid formulation in the capillary passage, the capillary passage being fitted within the first heater body, (iii) a second heater body arranged to be remote to the capillary passage and the first heater body, and (iv) at least one gas passage arranged such that gas is heated by the second heater body to produce a heated gas, the at least one gas passage having a gas passage inlet and a gas passage outlet, and wherein the at least one gas passage is separated from the capillary passage and the first heater body;
a pumping unit adapted to supply the liquid formulation to the aerosol generator unit;
an aerosol confinement member arranged at a distal end of the first heater body and configured to capture aerosols produced by the capillary passage;
a flow passage having an inlet end in fluid communication with an outlet of the aerosol confinement member and an outlet end adapted for connection to a patient interface which supplies ventilation to a patient's lungs; and
the aerosol confinement member connecting the capillary passage outlet and the gas passage outlet, wherein the capillary passage outlet is configured to inject the aerosols produced by the capillary passage into the aerosol confinement member and the gas passage outlet is configured to inject the gas heated by the second heater body into the aerosol confinement member, and wherein the aerosol confinement member is arranged to mix the aerosols produced by the capillary passage with the heated gas in a manner that reduces condensation of aerosol to produce a mixed aerosol and operable to direct the mixed aerosol into the inlet end of the flow passage.

US Pat. No. 10,188,820

RESPIRATORY APPARATUS

ResMed Limited, (AU)

1. A foam cushion assembly for a patient interface, the foam cushion assembly being adapted to couple with a patient interface frame, the foam cushion assembly comprising at least a nose seal portion, wherein the foam cushion assembly comprises:a foam cushion arranged for sealing about at least the nose of a patient, and
a cushion support component arranged to couple to the foam cushion, wherein the cushion support component is characterised by a height to thickness ratio of at least 3, around at least a portion of a periphery of the foam cushion,
wherein the cushion support component forms an inwardly overhanging peripheral lip for mounting the foam cushion.

US Pat. No. 10,188,818

RESPIRATORY MASK

Intersurgical AG, Vaduz ...

1. A respiratory mask for delivering inspiratory gas to a wearer, the mask comprising a mask body shaped to define a cavity adapted to fit about the mouth and nose of the patient, wherein the mask body comprises a nose cavity portion and a mouth cavity portion, the mask body being shaped such that the maximum depth of the cavity defined by the nose portion is greater than the depth of the cavity defined by the mouth portion, the nose cavity portion comprising an inspiratory gas inlet port and the mouth cavity portion comprising an expiratory gas monitoring port, at a location spaced from the inlet port, wherein the gas monitoring port is an inlet of a port connector formation depending from the mask body, and wherein said port connector formation is integral with the mask body.

US Pat. No. 10,188,817

SPEAKING VALVE

1. A speaking valve for laryngectomized and tracheotomized persons with a housing with a proximal first opening and a distal second opening, a filter which is at least partially surrounded by the housing, which filter is made of an elastic material, with a proximal first end and a distal second end, wherein the filter partially protrudes beyond an end face of the housing at the distal second opening, the housing having at least one flange extending outwardly from an outer wall of the housing to act as an enlarging aid and wherein a cover is connected by means of at least one partial region of its bottom surface to an upper side of the filter at its distal second end, whereby a diameter d1 of the cover is greater than a diameter d2 of the filter, so that an edge is formed that is protruding beyond a lateral filter wall of the filter, wherein by application of pressure onto the cover from an initial position, a lower surface of the edge of the cover at least partially interacts with the end face and the flange of the housing in order to produce a closed position of the speaking valve, and wherein the cover together with the filter returns to the initial position when unloaded.

US Pat. No. 10,188,816

SYSTEM FOR REMOVING INFECTIOUS SECRETIONS

Flosure Technologies LLC,...

1. A method of decreasing a probability of Ventilator Associated Pneumonia, said method comprising the steps of:a. inserting a tracheal/endotracheal device into the trachea of a patient;
b. inflating a balloon that surrounds a segment of said tracheal/endotracheal device,
whereby a segment of said tracheal/endotracheal device is disposed inferior to said balloon and a segment of said tracheal/endotracheal device is disposed superior to said balloon
c. delivering a mist through a port in said tracheal/endotracheal device, said mist being released in and delivered to the trachea, in an area that is inferior to said balloon;
d. simultaneously with the delivery step c, providing suction to capture mist or fluid from said inferior area in said trachea; and
e. delivering captured mist or fluid to a collection vessel that is disposed outside of said trachea,
wherein the provision of suction commences prior to the delivery of the mist and wherein the delivery of the mist is synchronized with the expulsion of air from the patient's lungs.

US Pat. No. 10,188,815

LARYNGEAL MASK WITH RETRACTABLE RIGID TAB AND MEANS FOR VENTILATION AND INTUBATION

Medcom Flow S.A., Barcel...

1. A laryngeal mask comprising the following elements:a rigid tube essentially in the form of a “J”, which has a lengthwise opening along its entire length; and
a flexible tube, also essentially in the form of a “J”, configured to be housed in the lengthwise opening of the rigid tube and separable from the rigid tube, and terminating at its distal end with an inflatable or gel laryngeal ring;
wherein the rigid tube terminates at its distal end with a rigid tongue-shaped tab, and wherein the flexible tube terminates at its distal end with a flexible sleeve configured to house the rigid tongue-shaped tab of the rigid tube in the interior of the flexible sleeve when the rigid tube and the flexible tube are coupled.

US Pat. No. 10,188,814

COMBINATION ANESTHESIA AND SCAVENGER SURGICAL MASK

13. A surgical mask assembly for administering and scavenging medical gases, comprising:an outer shell having a first gas port configured to be coupled to a negative pressure source, the outer shell defining a chamber with a rear-facing opening defined by a rim, and
an inner shell secured to the outer shell, the inner shell defining a chamber with a rear-facing opening defined by a rim and having a second gas port that includes (i) a distal end configured to be coupled to a positive pressure source, and (ii) a proximal end that opens into the chamber of the inner shell for supplying gas from the positive pressure source to the chamber of the inner shell, wherein (i) the rim of the inner shell is enveloped by the outer shell, (ii) the inner shell is configured to deliver gas to the patient's nose, but not envelop the patient's mouth, when the surgical mask assembly is positioned on the face of the patient, and (iii) the outer shell is configured to envelope both the patient's nose and mouth when the surgical mask assembly is positioned on the face of the patient.

US Pat. No. 10,188,812

NOSE CLIP

Dean M. Toriumi, Riversi...

1. A nose clip for clipping to a nose, the nose clip comprising:an outer support member configured to overlay a contour of an outside surface of the nose;
a pin connected to the outer support member and configured to pierce a side of the nose;
an inner support member configured to engage the pin and press against an outer lateral sidewall of the nasal cavity and distribute a force against the outer lateral sidewall to shape a contour of the outer lateral sidewall of the nasal cavity of the nose, wherein in a longitudinal direction, the inner support member follows a portion of an inner circumference of the nasal cavity defined between the outer lateral sidewall and the nasal septum; and
the outer support member, inner support member and pin member cooperating to increase a width of the nasal cavity to allow more air to flow through the nasal cavity.

US Pat. No. 10,188,811

NASAL SPRAY DEVICE

IVAX PHARMACEUTICALS IREL...

1. A nasal spray device for the delivery of a pharmaceutical formulation to a nasal cavity in metered doses, the nasal spray device comprising:a pressurised aerosol canister including a vial containing a pharmaceutical formulation comprising an active ingredient, and a propellant, the aerosol canister further including a metering valve having a valve stem; and
an actuator for the aerosol canister, the actuator including a stem block having a receptacle into which the valve stem of the metering valve of the aerosol canister is received and axially located, the valve stem being displaceable relative to the vial of the aerosol canister to actuate the metering valve of the aerosol canister, a sump extending below the receptacle, the stem block further defining a cylindrical discharge orifice for the pharmaceutical formulation and a transfer channel through which a dispensed dose of the pharmaceutical formulation is able to pass from the sump to the cylindrical discharge orifice,
wherein the actuator further comprises a delivery outlet for an aerosol plume, the cylindrical discharge orifice being arranged to direct the aerosol plume through the delivery outlet,
wherein the nasal spray device is adapted to produce an aerosol plume for a dispensed dose having a spray force value no greater than 40 millinewtons (mN) measured at a distance of 30 millimeters (mm) from the cylindrical discharge orifice, wherein the cylindrical discharge orifice has a diameter of 0.15 to 0.65 mm and a length of 0.6 mm to 1.0 mm, and wherein the transfer channel has a length of 3 to 20 mm and has a transverse dimension in a range of 1.2 mm to 2 mm, the transverse dimension being measured at its maximum extent.

US Pat. No. 10,188,809

THERAPY-SPECIFIC MEDICAL PUMP

Zyno Medical, LLC, Natic...

1. A programmable medical pump comprising:a housing holding:
a first and second metering pump wherein
the first metering pump is a syringe pump for receiving and activating a plunger providing delivery of a predetermined first volume of a first medicament from a syringe holding a first medicament;
the second metering pump is a peristaltic pump for receiving and activating actuators controlling delivery of a predetermined second volume of a second medicament through an IV tube attached to a medicament container, the syringe volume being smaller than the medicament container volume;
a controller independently controlling the syringe pump to deliver a first predetermined volume of the first medicament at a first predetermined flow rate and the peristaltic pump to deliver a second predetermined volume of the second medicament at a second predetermined flow rate;
an electronic memory holding a multi-session treatment schedule spanning multiple days describing different treatment sessions and treatment protocols for a delivery of liquid medicament through the syringe pump and peristaltic pump for each session;
an interface display;
a start control; and
an electronic computer communicating with the interface display, start control, syringe pump and peristaltic pump, and an electronic memory executing a stored program fixed in a non-transitory medium to:
(1) identify a current session of the treatment schedule;
(2) provide an alert to a patient indicating the current session is due;
(3) determine a treatment protocol for the current session; and
(4) activate, via the start control, the treatment protocol controlling a sequential delivery of the first medicament at the first predetermined flow rate followed by the second medicament at the second predetermined flow rate for the current session for both the first and second metering pumps;
wherein the interface display communicates with the electronic computer and wherein the electronic computer executes the stored program to display, via the interface display, (i) a calendar to identify a particular session based on a calendar day of the session, (ii) step by step instructions relative to the treatment protocol requiring user intervention, and (iii) a current session of the treatment protocol.

US Pat. No. 10,188,808

FIBER OPTIC DISTAL SENSOR CONTROLLED DRUG INJECTOR

THE JOHNS HOPKINS UNIVERS...

1. A motion-compensated injector system comprising:a handheld tool comprising a hollow shaft with a distal end configured for insertion into tissue of a subject to deliver a material to a target location of the tissue of the subject through the hollow shaft;
an optical coherence tomography-based optical detection system comprising:
an optical fiber having a distal end at a fixed distance from the distal end of the hollow shaft, and
an optical sensor configured to receive a signal from the optical fiber;
an actuator integrated into the handheld tool, the actuator configured to move the hollow shaft in an axial direction, the actuator comprising a linear motor directly connected to a rod to which the hollow shaft is fixed, the linear motor driving the rod to move the hollow shaft; and
a control unit to control the actuator,
wherein the optical detection system is configured to monitor a distance between the distal end of the optical fiber and a reference portion of the tissue of the subject,
wherein the control unit controls the actuator to move the hollow shaft to compensate for relative motion between the handheld tool and the portion of the tissue,
wherein the control unit is configured to control the actuator based on a closed-loop proportional-integral-derivative control algorithm to compensate for deformation of the tissue during insertion of the hollow shaft, and
wherein the optical fiber is adjacent but not concentric to the hollow shaft.

US Pat. No. 10,188,807

LOW RESIDUAL VOLUME SYRINGE/CONDUIT COMBINATION AND SYRINGE FOR SUCH A SYRINGE/CONDUIT COMBINATION

Linesbridge Pharma Group ...

1. A syringe/conduit combination comprising a syringe part and a conduit part connectable or connected to the syringe part;wherein one of said parts has a frustoconical male slip fitting and the other one of said parts has a female slip fitting having a frustoconical internal surface extending up to an internal end;
wherein said male slip fitting is inserted or insertable into said female slip fitting establishing a press fitted connection with the male slip fitting axially extending up to an axial distance of less than 0.1 mm from the internal end of the female slip fitting;
wherein a first liquid discharge channel extending through said male slip fitting and a second liquid discharge channel extending through said female slip fitting are in mutual serial communication for liquid transfer when said connection between said male and female fittings is established;
wherein the syringe part comprises a hollow barrel and a plunger inserted into the hollow barrel from a proximal end, axially displaceable in the hollow barrel and sealingly fitting against an internal wall of the hollow barrel;
wherein the plunger and the hollow barrel have abutments limiting axial displacement of the plunger in a distal direction to a maximally inserted position; and
wherein, when the male slip fitting is axially inserted into the female slip fitting, a distal end of the plunger when in its maximally inserted position is at an axial distance from an opposite one of the slip fittings that is equal to or less than the axial distance between the male slip fitting and the internal end of the female slip fitting.

US Pat. No. 10,188,806

DRIVE MECHANISM FOR A NEEDLE INSERTION ARRANGEMENT

Sanofi-Aventis Deutschlan...

1. A drive mechanism for a needle insertion arrangement, the drive mechanism comprising:a bistable mechanism with at least one pivoted link having two stable end positions (LEP, UEP) and an instable transitional central position (CP);
a spring biasing the at least one pivoted link out of the instable transitional central position (CP), wherein at least one trigger unit is arranged for moving the at least one pivoted link out of at least one of the stable end positions (LEP, UEP) towards and beyond the instable transitional central position (CP) against the bias of the spring; and
a forked needle retainer adapted to retain an injection needle, the forked needle retainer arranged to be linearly moved between a retracted position (RP) and an extended position (EP), wherein one end of the at least one pivoted link is adapted to abut an upper prong and a lower prong on the forked needle retainer,
wherein the upper prong is spaced from the lower prong for allowing a pre-determined free travel of the at least one pivoted link between disengaging one of the prongs and engaging the other one of the prongs.

US Pat. No. 10,188,805

TARGETING THERAPEUTIC AGENTS

Emory University, Atlant...

1. A method for targeting administration of a therapeutic agent to a subject, comprising:inserting a device including a sleeve defining a lumen and a frame disposed about an end of the sleeve into an organ lumen of an organ;
wherein the frame includes more than one arm extending from the end of the sleeve;
wherein the frame shapes a concavity into an outer wall of the organ between a first arm and a second arm of the frame;
guiding an administration device through a guide apparatus disposed on the sleeve so that the administration device is guided external to the organ lumen and the sleeve, between the first arm and the second arm, and proximate to the shaped concavity; and
administering a therapeutic agent into the shaped concavity.

US Pat. No. 10,188,804

CONTACT TRIGGER RELEASE NEEDLE GUARD

Safety Syringes, Inc., F...

1. A needle guard couplable to a syringe, the needle guard comprisinga lock collar slideably couplable to a syringe; and
a device shield transitionable from a first position in which a syringe sharp extends beyond the device shield to a second position in which the syringe sharp is covered by the device shield, the device shield comprising at least one radially deflectable retention arm,
wherein, in the first position, the lock collar and the device shield are engaged to hold the device shield in the first position against the bias of a biasing member urging the device shield toward the second position, and movement of the syringe sharp relative to the device shield disengages the device shield from the lock collar enabling the device shield to transition to the second position, and
wherein the lock collar includes at least one tab and the at least one retention arm engages the at least one tab to retain the device shield in the first position.

US Pat. No. 10,188,803

DISPOSABLE SAFE VEIN TRANSFUSION PUNCTURE NEEDLE

GEMTIER MEDICAL (SHANGHAI...

1. A disposable safe vein transfusion puncture needle, comprisinga needle head,
a needle base,
a needle sheath, sleeved on the needle head; and
a hose, communicated with the needle base,characterized in further comprisinga plurality of slidable components; and
a plurality of limiting mechanisms,
wherein,
the needle base is in a tubular shape, with one end stationary and communicated with the needle head and the other end connected to the hose;
each of the slidable components is in a tubular shape and has two open ends, the plurality of slidable components are sleeved on one another, the innermost slidable component is movably sleeved onto the needle base, and a sum of lengths of the plurality of slidable components in a moving direction is longer than the length of the needle head;
the limiting mechanisms are disposed on the plurality of slidable components as well as on the needle base and adapted for securing the innermost slidable component to the needle base as well as securing the plurality of slidable components to one another when the plurality of slidable components slide to completely shield the needle head,
the plurality of slidable components comprise a first slidable component movably sleeved on the needle base and a second slidable component movably sleeved on the first slidable component,
the limiting mechanisms comprise two elastic fasteners and four grooves, one of the elastic fasteners is disposed on the first slidable component, and the other elastic fastener is disposed on the second slidable component; two of the grooves are disposed on the needle base, and the other two grooves are circumferentially disposed on an exterior wall of the first slidable component; the elastic fasteners and the grooves are adapted for engaging with each other when the first slidable component and the second slidable component slide to completely shield the needle head or when the needle head is completely exposed, so as to limit the movement of the first slidable component and the second slidable component,
one end of the second slidable component close to the hose has a smooth projection portion circumferentially disposed thereon,
a smooth planar surface is disposed on a lateral side of the second slidable component, and the plane of the smooth planar surface forms an angle of 5°-20° with an axial line of the needle head; the second slidable component has a notch disposed on the lateral side with the smooth planar surface, and the notch is in a plane parallel to an axial line of the needle head; one end of the notch extends to an open end of the second slidable component away from the hose, and the other end of the notch extends to intersect with the smooth planar surface.

US Pat. No. 10,188,802

SHEATH REMOVAL MECHANISM

Sanofi-Aventis Deutschlan...

1. A sheath removal mechanism for removing a protective needle sheath from a medicament container, the medicament container arrangeable in a medicament delivery device, wherein the sheath removal mechanism comprises:a cap attachable to a distal end of the medicament delivery device,
wherein the cap comprises a plurality of ledges adapted to engage the protective needle sheath,
wherein the plurality of ledges is respectively arranged on a plurality of compliant sheath removal beams arranged on the cap,
wherein the plurality of ledges have a clearance therebetween that is sufficiently wide to allow a protective needle sheath to pass through the plurality of ledges when the plurality of compliant sheath removal beams is in a relaxed state, and
wherein one or more snap fits are respectively arranged on the plurality of compliant sheath removal beams in a manner such that the one or more snap fits engage one another to secure neighboring beams of the plurality of compliant sheath removal beams to each other when the plurality of compliant sheath removal beams is deflected radially inward.

US Pat. No. 10,188,801

MECHANISM FOR PREVENTING SELECTION OF A DOSE

Sanofi-Aventis Deutschlan...

1. A dose setting mechanism for use with a drug delivery device, the dose setting mechanism comprising:a dose setter for selecting a dose; and
a locking mechanism configured to prevent movement of the dose setter and selection of the dose,
wherein the locking mechanism is configured such that inserting a correct cartridge into the drug delivery device unlocks the locking mechanism so as to allow movement of the dose setter and selection of the dose, and
wherein the locking mechanism is configured such that inserting an incorrect cartridge into the drug delivery device locks the locking mechanism so as to prevent the dose setter from setting a dose, wherein the locking mechanism prevents the dose setter from rotating, and wherein, when the correct cartridge is inserted into the drug delivery device, the locking mechanism unlocks so as to allow the dose setter to rotate.

US Pat. No. 10,188,800

DRIVE ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. A drive assembly for a drug delivery device, comprising:a guide nut, the guide nut being rotatable around an axis of the assembly,
a locking means, the locking means being radially movable with respect to the axis in order to engage with the guide nut and to inhibit a rotation of the guide nut,
a body in which the guide nut and the locking means are arranged,
a piston rod,
a cartridge holder that can be attached to and removed from the body, and
a fastener, the fastener being part of or fastened to the cartridge holder and being provided to move the locking means radially with respect to the axis thereby engaging the locking means with the guide nut when the cartridge holder is attached to the body, and to hold the locking means in a position in which the locking means is engaged with the guide nut for drug delivery,
wherein
a screw thread coupling the guide nut and the piston rod enables a helical movement of the piston rod with respect to the guide nut, the helical movement comprising a rotation around the axis and a simultaneous shift along the axis,
the locking means is a resilient element having a first end fastened to the body, the locking means extending in an azimuthal direction from the first end to a second, free end for engaging with the guide nut,
the fastener is a longitudinally protruding part of the cartridge holder, and
the fastener is moved on a circle that is concentric with the guide nut, and is thus made to slide over the locking means and engages the locking means with a structured outer surface of the guide nut by a rotation of the cartridge holder with respect to the body.

US Pat. No. 10,188,798

MEDICAMENT DELIVERY DEVICE

SHL GROUP AB, Nacka Stra...

1. A medicament delivery device comprising:a housing comprising a surface configured for contacting a patient's skin;
a medicament container disposed within the housing, the medicament container comprising a medicament contained behind a movable wall;
an injection needle positioned within the housing and in fluid communication with the medicament container;
a power source configured to store accumulated energy;
a plunger that moves relative to and within the medicament container immediately upon release of the accumulated energy, where the power source acts directly on the plunger such that the plunger directly contacts and moves the movable wall of the medicament container to expel medicament from the medicament container; and
an indication mechanism that is acted upon and directly moved by the plunger when the plunger moves relative to the housing and where the indication mechanism is movable only during delivery of the medicament, where the indication mechanism is not an integral part of the plunger, but is a separate component independent of the plunger and that is positioned within the housing and directly operatively associated with the plunger such that movement of the plunger directly causes separate movement of the indication mechanism only during delivery of the medicament, where a portion of the indication mechanism is visible from outside the device housing indicating that delivery of the medicament is substantially complete.

US Pat. No. 10,188,797

PHARMACEUTICAL INJECTION DEVICE

PHC HOLDINGS CORPORATION,...

1. A pharmaceutical injection device, comprising:a main body case having a first end side, the first end side having an injection needle mounting portion and an injection needle mounted to the injection needle mounting portion;
a pharmaceutical syringe mounting portion that is provided inside the main body case and to which a pharmaceutical syringe is mounted;
a piston that is provided movably with respect to the pharmaceutical syringe;
a drive mechanism configured to drive the piston;
a cover that covers the injection needle mounting portion in an opened or closed state wherein, in the opened state of the cover, the injection needle mounting portion is exposed to an outside while the cover is still attached to the first end side of the main body case;
a stepped part that is formed on a rear side of the injection needle in a piercing direction; and
an opening and closing mechanism for the cover, provided on the first end side of the main body case,
wherein, in the opened state of the cover, a distal end face of the stepped part on an injection needle side is positioned at substantially a same height as a front of the cover, and a surface of the cover is a face that is configured to come into contact with a skin of a patient at an outer peripheral position of the injection needle mounting portion,
wherein, in the closed state of the cover, the injection needle mounting portion is not exposed to the outside while the cover is still attached to the first end side of the main body case, and
wherein the opening and closing mechanism includes:
a first slide pin provided near the cover on an injection needle mounting portion side of the cover;
a first slide groove configured to guide a sliding of the first slide pin in an outer peripheral direction of the injection needle mounting portion;
a first slide spring configured to bias the first slide pin in a closing direction of the cover;
a second slide pin provided on an outer peripheral side of the injection needle mounting portion;
a second slide groove configured to guide a sliding of the second slide pin in the outer peripheral direction of the injection needle mounting portion; and
a second slide spring that is in communication with the second slide pin and is configured to bias in the closing direction of the cover.

US Pat. No. 10,188,796

METHOD AND SYSTEM FOR MANAGEMENT OF DIABETES WITH A GLUCOSE MONITOR AND INFUSION PUMP TO PROVIDE FEEDBACK ON BOLUS DOSING

LifeScan IP Holdings, LLC...

1. A method for operating a diabetes management system having an infusion pump, at least one glucose monitor and a microcontroller, the method comprising the following steps performed with the microcontroller:determining a glucose measurement in which a fluid sample with glucose is transformed into enzymatic byproducts by application of electrical signals to the sample;
calculating a bolus recommendation based on the glucose measurement made by the determining step;
evaluating whether the bolus recommendation was followed by a user of the system;
in the event the bolus recommendation was not followed by the user then:
storing the actual bolus delivered by the infusion pump;
measuring the glucose value in subsequent fluid samples and if the glucose values over time is greater than a predetermined high trend threshold then annunciating a high glucose trend, along with the recommended bolus and the actual bolus delivered by the pump otherwise if the glucose values over time is less than a predetermined low trend threshold then annunciating a low glucose trend along with both the recommended bolus and the actual bolus delivered by the pump.

US Pat. No. 10,188,795

BLOOD GLUCOSE CONTROL SYSTEM

Trustees of Boston Univer...

1. A sensor-driven glucose control system, comprising:an insulin delivery device operative in response to an insulin dose control signal to infuse insulin into the subject; and
a controller operative to generate the insulin dose control signal by:
(1) continually administering priming doses of insulin at respective times, each priming dose being of a respective amount and having a prescribed interval of action;
(2) receiving information regarding total amounts of insulin administered during the prescribed intervals of action, each total amount including an aggregation of total doses administered in response to a glucose level signal; and
(3) automatically adapting the amounts of the priming doses in response to a mathematical relationship, over respective periods each spanning multiple prescribed intervals of action, between the amounts of the priming doses and the total amounts of insulin administered during the prescribed intervals of action.

US Pat. No. 10,188,791

SYSTEM AND METHOD FOR ASSURING PATIENT MEDICATION AND FLUID DELIVERY AT THE CLINICAL POINT OF USE

Becton, Dickinson and Com...

1. A system comprising:a wearable electronic device configured to be worn by a user comprising:
a housing,
at least one imaging sensor associated with the housing,
a data transmission interface for sending data to or receiving data from an external electronic device,
a data reporting accessory for providing data to the user,
a microprocessor for managing the at least one imaging sensor, the data transmission interface, and the data reporting accessory, and
a program for acquiring and processing images from the at least one imaging sensor;
a fluid delivery apparatus for passively or actively delivering a therapeutic agent to a patient; and
one or more identification tags attached to or integrally formed with the fluid delivery apparatus,
wherein the program processes an image captured by the at least one imaging sensor to identify the one or more identification tags and acquires fluid delivery apparatus information from the one or more identification tags, and
wherein the program processes a series of images captured by the at least one imaging sensor to determine insertion of a portion of the fluid delivery apparatus in the patient and an indwell time of the portion of the fluid delivery apparatus within the patient, and
wherein the system alerts the user in response to the indwell time of the portion of the fluid delivery apparatus within the patient satisfying a time limit.

US Pat. No. 10,188,790

INDWELLING ASSEMBLY

TERUMO KABUSHIKI KAISHA, ...

1. A method comprising:positioning an assembled indwelling assembly adjacent a patient, the assembled indwelling assembly comprising: an inner needle possessing a sharp needlepoint at a distal end; an inner needle hub fixed to a proximal portion of the inner needle; a hollow outer member in which the inner needle is positioned; an outer member hub fixed to a proximal portion of the hollow outer member; and an elongated member connected to the outer member hub by a hinge structure allowing the elongated member to rotate relative to the outer member hub about a hinge axis, the elongated member extending in a distal direction from the hinge structure;
puncturing a blood vessel of the patient with the sharp needlepoint of the inner needle while the elongated member extends in the distal direction from the hinge structure;
advancing the hollow outer member in the distal direction along the inner needle such that a distal portion of the hollow outer member is inserted to a target position in the blood vessel, the advancing of the hollow outer member in the distal direction along the inner needle being performed while the elongated member extends in the distal direction from the hinge structure, the advancing of the hollow outer member in the distal direction including advancing the hollow outer member in the distal direction together with the outer member hub and the elongated member,
moving the inner needle hub in a proximal direction while simultaneously maintaining the distal portion of the hollow outer member indwelled in the blood vessel such that the inner needle is pulled out from and entirely removed from the hollow outer member; and
rotating the elongated member about the hinge axis after the inner needle is entirely removed from the hollow outer member so that the elongated member rotates relative to the outer member hub, the rotating of the elongated member about the hinge axis including rotating the elongated member away from the distal end of the hollow member.

US Pat. No. 10,188,789

FLUID INFUSION DEVICE WITH SAFETY COUPLING

Medtronic MiniMed, Inc., ...

1. A fluid infusion device, comprising:a drive system that includes a movable slide, the slide including a proximal end opposite a distal end, the proximal end including a projection having a first coupling device; and
a fluid reservoir removably received within a housing of the fluid infusion device that includes a barrel and a stopper disposed within the barrel, the stopper movable relative to the barrel by the slide to advance a fluid out of the fluid reservoir, the stopper including a distal stopper end opposite a proximal stopper end, with a counterbore defined through the distal stopper end, the stopper having a second coupling device coupled to the proximal stopper end, the slide receivable within the barrel such that the proximal end of the slide is adjacent to the distal stopper end and the projection is received within the counterbore, and the second coupling device cooperates with the first coupling device to resist the movement of the stopper relative to the slide.

US Pat. No. 10,188,788

SYSTEM AND METHODS FOR MEDICAMENT INFUSION

Medirio S.A., Visp (CH)

1. A system for trans-dermal delivery of a dose of a medicament, comprising a delivery device and a separate hand-held drive device, whereinthe delivery device is configured to be placed in dermal contact with a patient, the delivery device comprising
a reservoir for holding the medicament to be delivered,
a trans-dermal injection element for delivering the dose of the medicament to the patient,
a control unit for controlling the transformation of external energy transferred from the hand-held drive device to the delivery device into a pumping force and for allowing a specific dose of the medicament to be pumped when the dose is requested, the control unit comprising
one or more rotors and/or one or more axial pump elements for transforming rotational and/or axial force into the pumping force, and
at least one safe-lock mechanism for preventing mechanical action to cause rotation of the at least one or more rotors and/or movement of the one or more axial pump elements thereby preventing passage of the medicament from the reservoir to the trans-dermal injection element unless a dose is requested;
the separate hand-held drive device being configured to be placed temporarily in proximity to the delivery device when a dose of medicament is required, the hand-held drive device comprising an activation unit for activating the control unit of the delivery device, the activation unit comprising
at least one unlocking element to provide energy to the control unit of the delivery device for unlocking the at least one safe-lock mechanism and a drive unit to provide energy for any of the one or more rotors and/or one or more axial pump elements of the control unit, only when the separate hand-held drive device is in proximity to the delivery device, and
wherein the hand-held drive device comprises a sensor capable of detecting the amount of energy being transferred and/or transformed into pumping force.

US Pat. No. 10,188,786

METHOD AND SYSTEM FOR TREATING BLADDER CONDITIONS

Elmedical Ltd., Hod-HaSh...

1. A method of treating an overactive bladder or interstitial cystitis comprising:(a) delivering a first volume of a fluid maintained at a temperature of 40-48° C. directly into a urinary bladder of a subject having the overactive bladder or interstitial cystitis and circulating said volume of fluid within the urinary bladder;
(b) gradually delivering a second volume of said fluid maintained at a temperature of 40-48° C. into said urinary bladder up to a predetermined fluid volume and/or pressure based on a tolerance of said subject to thereby relax detrusor muscles and stretch the urinary bladder; and
(c) evacuating said fluid and urine from said urinary bladder.

US Pat. No. 10,188,778

ARTIFICIAL HEART

Stephen K. Shu, Irvine, ...

1. An artificial heart, comprising:an outer housing comprising a right heart valve plate and a left heart valve plate spaced axially apart by a first bellows spring and a second bellows spring;
a solenoid connected to a first drive coil and a second drive coil, the first drive coil operably connected to the right heart valve plate and the second drive coil operably connected to the left heart valve plate;
a magnet operably connected to a plate structure spaced axially between the first drive coil and the second drive coil, the magnet operably connected to a first end of the first bellows spring and a first end of the second bellows spring, the magnet configured to move axially upon activation of the first drive coil and the second drive coil resulting in conversion of electrical energy to mechanical energy, thereby axially elongating one of the first bellows spring and the second bellows spring and simultaneously contracting the other of the first bellows spring and the second bellows spring resulting in the release of energy, moving blood in or out of the artificial heart by movement of the plate structure;
at least one sensor configured to determine at least one of the position, velocity, and direction of travel of the magnet; and
a servomechanism controller configured to receive data from the sensor and control power to the first drive coil and the second drive coil, thereby actuating the magnet and the plate structure.

US Pat. No. 10,188,777

LIPOSUCTION DEVICE AND SYSTEM AND USE THEREOF

Aurastem LLC, Solana Bea...

1. A device that allows for the removal of adipose tissue with a needle(s), comprising a needle hub that comprises at least one needle having a needle barrel that contains between 1-1000 holes around the circumference of the needle barrel which allows passage of adipose tissue and other lipoaspirate and a guide that prevents the over insertion and under insertion of the needle and thus allows collection of subcutaneous adipose tissue at desired depth,wherein the guide is curved to allow the needle to puncture skin and the needle is adapted to remain in the subcutaneous layer of adipose tissue.

US Pat. No. 10,188,776

NEGATIVE PRESSURE DEVICE

1. Apparatus for providing negative pressure at a wound site, the apparatus comprising:a negative pressure reservoir configured to contain a first zone of negative pressure;
a chamber configured to contain a second zone of negative pressure, the chamber configured to communicate negative pressure to a wound dressing; and
a valve element arranged to selectively provide a fluid communication path between the reservoir and the chamber, the valve element comprising an exterior surface exposed to an ambient atmospheric pressure, an inner surface fixed relative to the exterior surface such that movement of the exterior surface causes movement of the inner surface, a first portion of the inner surface configured to be exposed to the first zone of negative pressure, and a second portion of the inner surface configured to be exposed to the second zone of negative pressure, the valve element further arranged to selectively block the fluid communication path when the exterior surface moves to a first position, the valve element further arranged to selectively open the fluid communication path when the exterior surface moves to a second position, wherein the exterior surface moves from the first position to the second position as a result of the ambient atmospheric pressure acting on the exterior surface and a negative pressure acting on the inner surface.

US Pat. No. 10,188,775

LID FOR A MEDICAL WASTE FLUID COLLECTION AND DISPOSAL SYSTEM

Dornoch Medical Systems, ...

1. A lid for a medical waste collection canister, the lid comprising:a head portion comprising:
three cylindrical suction ports extending along a first, second, and third longitudinal axis, respectively, each suction port having a first diameter and each suction port adapted to be connected to suction tubing and further adapted to receive medical waste through a top of the suction port and pass the medical waste through a bottom of the suction port;
a cylindrical auxiliary vacuum port extending along a fourth longitudinal axis and having a second diameter; and
a plurality of tabs spaced apart along a circumferential edge of the head portion; and
a cylindrical portion coupled to the head portion and extending away from a bottom of the head portion along a fifth longitudinal axis,
wherein each of the suction ports and the vacuum port have a cap that is tethered to the lid, each cap sized to correspond to a size of the suction ports or vacuum port.

US Pat. No. 10,188,771

METHOD OF TREATING PERIPHERAL ARTERY DISEASES IN LOWER LIMBS

TERUMO KABUSHIKI KAISHA, ...

1. A method of treating peripheral artery diseases in lower limbs, comprisinginserting a medical device into a peripheral blood vessel, the medical device comprising a polyamide expandable member possessing a polyamide surface on which a drug coating layer is disposed, the drug coating layer being applied to the polyamide surface of the polyamide expandable member by reverse rotation in which the expandable member is rotated in an opposite direction of dispensing the drug coating layer and in which the drug coating layer is dispensed by a dispenser in contact with the polyamide surface of the expandable member, the drug coating layer having a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the polyamide surface of the polyamide expandable member, each of the crystal particles being independently formed on the polyamide surface of the polyamide expandable member,
expanding the polyamide expandable member,
pressing the drug coating layer to a blood vessel wall of the peripheral blood vessel such that at least part of the plurality of crystals is transferred to the blood vessel wall, and
deflating the polyamide expandable member such that a pharmacokinetics profile is presented in which a drug concentration in the blood vessels is kept for the inhibition of smooth muscle cell proliferation in a first drug-concentration period of time, and for the non-inhibition of endothelial cell growth in a later second drug-concentration period of time, the drug-concentration in the first drug-concentration period of time being higher than the drug-concentration in the second drug-concentration period of time.

US Pat. No. 10,188,768

MINIATURE SCENT GENERATING DEVICE

NATIONAL TSING HUA UNIVER...

9. A miniature non-atomizer type scent generating device, comprising:a scented component including a housing, a chamber located in the housing, a ventilation opening penetrating the housing to communicate with the chamber, and a vibration unit disposed in the chamber;
a plurality of solid-state scented particles or microcapsules encapsulating essences disposed in the chamber and having a scent; and
a driving unit comprising a control circuit and connected to the vibration unit;
wherein the vibration unit is controlled by the driving unit to produce a back and forth vibration which directly pushes gas inside the chamber and accordingly induces a unidirectional airflow of perturbation in the chamber;
wherein the unidirectional airflow of perturbation accompanies the solid-state scented particles or microcapsules encapsulating essences flowing through the ventilation opening and out of the chamber to enhance the dispersing of the scent;
wherein the vibration unit comprises:
a piezoelectric film layer;
a first electrode layer, connected to the piezoelectric film; and
a second electrode layer, connected to the piezoelectric film;
wherein the piezoelectric film layer is sandwiched between the first electrode layer and the second electrode layer, and the first electrode layer and the second electrode layer are respectively electrically connected to the driving unit to generate a varying electric field at the piezoelectric film to cause the piezoelectric film layer to produce the vibration.

US Pat. No. 10,188,767

SCENT PRESENTATION METHOD, SCENT PRESENTATION APPARATUS, AND OLFACTION IMPROVING APPARATUS

KEIO UNIVERSITY, Tokyo (...

1. An olfaction improvement method comprising:determining a detection threshold at which a test subject is able to detect a scent selected from among a plurality of scents by
presenting the scent by pulse ejecting the scent for a specified time interval between from about 100 ms to about 300 ms to vary the intensity of the scent,
detecting an operation of a terminal device by the test subject upon detection of the scent by the test subject, and
setting the intensity of the scent detected by the test subject over at least two consecutive trials as the detection threshold of the test subject for each scent from among the plurality of scents, wherein the plurality of scents are selected and presented in a predetermined sequence;
generating a random number to randomly determine a presentation sequence of the plurality of scents;
determining presentation conditions that include the intensity of the scent and the pulse ejection duration of the scent based on the detection threshold of the test subject;
presenting the scent through pulse ejection based on the determined presentation condition; and
altering the presentation conditions by reducing the intensity of the scent, the pulse ejection duration of the scent, or both the intensity of the scent and the pulse ejection duration of the scent relative to the detection threshold of the test subject when presenting the scent at a subsequent time, wherein
the scent is pulse ejected by a fluid ejection device.

US Pat. No. 10,188,766

PURIFIED HYDROGEN PEROXIDE GAS MICROBIAL CONTROL METHODS AND DEVICES

Synexis LLC, Kansas City...

1. A diffuser apparatus for producing non-hydrated purified hydrogen peroxide gas (PHPG) from humid ambient air-comprising:(a) an air distribution mechanism providing an airflow of said humid ambient air;
(b) a source of ultraviolet light; and
(c) a metal, or metal oxide catalyst on a thin, air-permeable substrate structure having a surface,
wherein said air flow is through; said surface and has a residence time on said air-permeable substrate structure of less than a second, wherein said non-hydrated purified hydrogen peroxide gas comprises 0.015 ppm of ozone or less and is directed out of said diffuser apparatus and into an environment when said apparatus is in operation.

US Pat. No. 10,188,765

SUPER DRY FOG GENERATOR

HUBEI HOPE PHARMACEUTICAL...

1. A super dry fog generator comprising a liquid-storage device, an atomization device, an air-blower and a dry separation device; wherein the dry separation device comprises a top and a bottom, and an opening on the top; wherein the dry separation device is above the liquid-storage device and connected with the liquid-storage device; wherein the atomization device is located at an exterior of the liquid-storage device and comprises two ends; wherein the two ends of the atomization device are connected with the air-blower and an interior of the dry separation device, respectively; wherein the atomization device is connected with the liquid-storage device, and a liquid entering into an interior of the atomization device is blown into the interior of the dry separation device by the air-blower, wherein the dry separation device comprises at least two connected cavity structures; and wherein the bottom of the dry separation device is joined to a top of the liquid-storage device and connected with an interior of the liquid-storage device.

US Pat. No. 10,188,764

APPARATUS FOR DISINFECTING AN ENCLOSED SPACE

Nevoa Life Sciences, Sco...

1. An apparatus for disinfecting an area or enclosed space, the apparatus comprising:a device for producing a fog comprising liquid droplets having diameters between about 0.5 micron and about 20 microns;
at least one port for discharging the fog into the area or enclosed space;
an in-line dehumidifying device; and
a low-moisture droplet mesh screen upstream of the dehumidifying device.

US Pat. No. 10,188,762

STERILIZING METHOD AND APPARATUS

Turbett Surgical LLC, Ro...

9. A method of sterilizing, the method comprising:(a) occluding a vent port located on one of a sidewall and a door of a sterilizing cabinet with a filter, the sterilizing cabinet having an internal, port-free, bottom surface;
(b) performing a sterilization cycle on the sterilizing cabinet; and
(c) inducing condensate formed during the sterilization cycle to flow along the port-free, bottom surface of the sterilizing cabinet towards the filter of the vent port located on one of a sidewall and a door of the sterilizing cabinet.

US Pat. No. 10,188,759

CONJUGATES FOR IMAGING

Endocyte, Inc., West Laf...

1. A conjugate, or a pharmaceutically acceptable salt thereof, of the formula

US Pat. No. 10,188,758

ORGANIC COMPOUNDS

INTRA-CELLULAR THERAPIES,...

1. A compound of Formula I:in free or salt form, wherein:R1 and R2 are independently H or C1-4 alkyl; and
R3 is —O—C2-4 alkyl optionally substituted with hydroxy.

US Pat. No. 10,188,756

IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY

The General Hospital Corp...

1. A compound of formula (I):
wherein R1 is a moiety including a substituted or unsubstituted adamantyl group and a contrast agent,
wherein R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocyclic, and
wherein n is an integer selected from 0 or 1, and
wherein the compound has a brain to plasma ratio greater than 1, and wherein at least one atom in R1 is replaced with a positron emitter selected from the group consisting of 11C, 13N, 15O, 18F, 34mCl, 38K, 45Ti, 51Mn, 52mMn, 52Fe, 55Co, 60Cu, 61Cu, 62Cu, 64Cu, 66Ga, 68Ga, 71As, 72As, 74As, 75Br, 76Br, 82Rb, 86Y, 89Zr, 90Nb, 94mTc, 110mIn, 118Sb, 120I, 121I, 122I, and 124I.

US Pat. No. 10,188,753

METHOD FOR INTEGRATING NANOPARTICLES AS PART OF A HYDROGEL MATRIX

Verily Life Sciences LLC,...

1. A method for forming a nanosensor-containing crosslinked polymer, the method comprising:forming a mixture comprising a nanosensor, a crosslinkable polymer precursor, and a surfactant, wherein
the nanosensor comprises a hydrophobic nanoparticle having a detectable label configured to interact with a specific analyte present in a transdermal environment, and
the surfactant comprises one or more chemically-reactive groups capable of forming a covalent bond with the crosslinkable polymer precursor; and
subjecting the mixture to conditions suitable to initiate crosslinking of the crosslinkable polymer precursor, such that the nanosensor is disposed in the crosslinked polymer, and the crosslinked polymer is covalently bound to the surfactant.

US Pat. No. 10,188,746

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

MEDIMMUNE LIMITED, Cambr...

1. A conjugate of formula (A):
and salts and solvates thereof, wherein:
D represents either group D1 or D2:

the dotted line indicates the optional presence of a double bond between C2 and C3;
when there is a double bond present between C2 and C3, R2 is selected from the group consisting of:
(ia) C5-10 aryl group, optionally substituted by one or more substituents selected from the group comprising: halo, nitro, cyano, ether, carboxy, ester, C1-7 alkyl, C3-7 heterocyclyl and bis-oxy-C1-3 alkylene;
(ib) C1-5 saturated aliphatic alkyl;
(ic) C3-6 saturated cycloalkyl;
(id)
wherein each of R31, R32 and R33 are independently selected from H, C1-3 saturated alkyl, C2-3 alkenyl, C2-3 alkynyl and cyclopropyl, where the total number of carbon atoms in the R2 group is no more than 5;(ie)
wherein one of R35a and R35b is H and the other is selected from: phenyl, which phenyl is optionally substituted by a group selected from halo, methyl, methoxy; pyridyl; and thiophenyl; and(if)
where R34 is selected from: H; C1-3 saturated alkyl; C2-3 alkenyl; C2-3 alkynyl; cyclopropyl; phenyl, which phenyl is optionally substituted by a group selected from halo, methyl, methoxy; pyridyl; and thiophenyl;(ig) halo;
when there is a single bond present between C2 and C3,
R2 is
where R36a and R36b are independently selected from H, F, C1-4 saturated alkyl, C2-3 alkenyl, which alkyl and alkenyl groups are optionally substituted by a group selected from C1-4 alkyl amido and C1-4 alkyl ester; or, when one of R16a and R16b is H, the other is selected from nitrile and a C1-4 alkyl ester;R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, SnMe3 and halo;
either
(a) R10 is H, and R11 is OH or ORA, where RA is C1-4 alkyl; or
(b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or
(c) R10 is H and R11 is OSOZM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation; or
(d) R11 is OH or ORA, where RA is C1-4 alkyl and R10 is selected from:
where Rz is selected from:(z-i)

(z-ii) OC(?O)CH3;
(z-iii) NO2;
(z-iv) OMe;
(z-v) glucoronide;
(z-vi) —C(?O)—X1—NHC(?O)X2—NH—RZC, where —C(?O)—X1—NH— and —C(?O)—X2—NH— represent natural amino acid residues and Rzc is selected from Me, OMe, OCH2CH2OMe;
Y is selected from formulae A1 and A2:

Z1 is a C1-3 alkylene group;
Z2 is a C1-3 alkylene group;
Q is:
where QX is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue;L is a linker connected to a cell binding agent;
CBA is the cell binding agent;
n is an integer between 0 and 48;
R and R? are each independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups, and optionally in relation to the group NRR?, R and R? together with the nitrogen atom to which they are attached form an optionally substituted 4-, 5-, 6- or 7-membered heterocyclic ring;
R8 is either:
(a) independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, SnMe3 and halo; or
(b) of formula A*:
wherein:D? represents either group D?1 or D2:

wherein the dotted line indicates the optional presence of a double bond between C2? and C3?;
R17 is independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, SnMe3 and halo;
R? is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms, e.g. O, S, N(H), NMe and/or aromatic rings, e.g. benzene or pyridine, which rings are optionally substituted; and
X and X? are independently selected from O, S and N(H); and
R22, R16, R19, R20 and R21 are as defined for R2, R6, R9, R10 and R11 respectively.

US Pat. No. 10,188,745

BINDING PROTEIN DRUG CONJUGATES COMPRISING ANTHRACYCLINE DERIVATIVES

NBE-THERAPEUTICS AG, Bas...

1. A binding protein-drug conjugate (BPDC) comprising an anthracycline (PNU) derivative, the BPDC having the following formula:
wherein
a) each of L1-L3 represents a linker, wherein L1 is optional and both L2 and L3 are mandatory,
b) L1, when present, represents an alkylene-amino linker or an alkylene-diamino linker,
c) L2 represents an oligo-glycine peptide,
d) L3 represents a peptide motif that results from specific cleavage of a sortase enzyme recognition motif,
e) X and Y each represent one or more optional linkers,
f) BP is a binding protein, and
g) n is an integer ?1 and ?10.

US Pat. No. 10,188,743

CYTISINE-LINKED ISOFLAVONOID ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER

University of Kentucky Re...

1. A method of treating prostate or colorectal cancer, the method comprising administering to a patient in need of prostate or colorectal cancer treatment an effective amount of a cytisine-linked isoflavonoid compound represented by formula (I):
or pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof,
wherein Ar is an aryl or heteroaryl; n is an integer from 1 to 5; each X is independently a halide, or alkoxy, or more than one X on Ar together form a cyclic ether structure; and wherein the compound is substituted on the C-2 position with H, alkyl, cycloalkyl or alkoxy, substituted on the C-5, C-6, C-7, and C-8 positions independently with H, hydroxy (OH), alkyl, cycloalkyl, alkoxy, L is a substituted or unsubstituted di-radical linker group that links the cytisinyl group to either the C-5, C-6, C-7 or C-8 position.

US Pat. No. 10,188,728

COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER

1. A composition for treating cancer comprising targeted liposomes comprising a chemotherapy agent and a sensitizer for the chemotherapy agent, and non-targeted liposomes comprising an anti-angiogenic agent, wherein:said targeted liposomes are immunoliposomes that bind to Her-2/neu;
said chemotherapy agent is doxorubicin, carboplatin, cisplatin, cyclophosphamide, docetaxel, erlotinib, etoposide, fluorouracil, gemcitabine, imatinib mesylate, irinotecan, methotrexate, paclitaxel, sorafinib, sunitinib, topotecan, vincristine or vinblastine;
said sensitizer is verapamil; and
said anti-angiogenic agent is bevacizumab.

US Pat. No. 10,188,727

BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS

YALE UNIVERSITY, New Hav...

1. A compound according to the chemical structure:

wherein n is 5 and n? is 4, or
a pharmaceutically acceptable salt thereof.

US Pat. No. 10,188,709

COMPOSITIONS AND METHODS FOR THE TREATMENT OF PHENYLKETONURIA (PKU)

University of the Science...

1. A pharmaceutical composition comprising a microcapsule, which is enveloped by a membrane comprising ethyl cellulose, and wherein the microcapsule comprises in its interior phenylalanine ammonia lyase and fatty acid-free albumin, wherein the microcapsule has a diameter ranging from about 1 ?m to about 10 ?m.

US Pat. No. 10,188,690

USE OF KAEMPFERIA PARVIFLORA WALL. EX. BAKER EXTRACTS OR FLAVONE COMPOUND FOR PREVENTING OR TREATING MUSCLE DISEASES, OR IMPROVING MUSCLE FUNCTION

AAT COSTECH CO., LTD., S...

1. A method of treating a human suffering from muscle atrophy comprising administering to said human suffering from muscle atrophy a therapeutically effective amount of a compound represented by Formula 4 or salt thereof to the human suffering from muscle atrophy,wherein Formula 4 is as follows:

wherein each of R1, R2, and R3 is independently selected from the group consisting of hydrogen and methoxy, and
wherein the human has a muscle disease selected from the group consisting of atony, muscular dystrophy, myasthenia, and sarcopenia.

US Pat. No. 10,188,682

MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE

MEDIZINISCHE HOCHSCHULE H...

1. A method of treatment of liver failure and/or for the protection of hepatocytes against apoptosis and/or for the regeneration of hepatocytes, the method comprising a step of administering to a patient in need of treatment a compound, which is an inhibitor of the activity of MKK4, MKK4 being encoded by the mRNA of SEQ ID NO: 1204, wherein the compound is selected from the group consisting of the following compounds:

US Pat. No. 10,188,677

IRON SUPPLEMENT COMPOSITION

THE D DROPS COMPANY INC.,...

1. A composition consisting of:a non-encapsulated iron salt; and
a carrier of a digestible edible oil that is a liquid at 20° C.

US Pat. No. 10,188,674

PARENTERAL FORMULATIONS FOR ADMINISTERING MACROLIDE ANTIBIOTICS

CEMPRA PHARMACEUTICALS, I...

1. A pharmaceutical composition adapted for intravenous administration, the composition comprising one or more antibiotic compounds and a formulating agent, wherein the formulating agent comprises an amino acid selected from the group consisting of arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, histidine, lysine, ornithine, serine, threonine, tryptophan, and tyrosine, and pharmaceutically acceptable salts thereof, and combinations thereof; and where at least one of the one or more antibiotic compounds is of the formula
or a pharmaceutically acceptable salt thereof, wherein:
R10 is hydrogen, acyl or a prodrug moiety;
W is H, F, Cl, Br, I, or OH;
A is CH2, C(O), C(O)O, C(O)NH, S(O)2, S(O)2NH, or C(O)NHS(O)2;
B is C2-C10 alkenylene or C1-C10 alkylene; and
C is hydrogen, hydroxy, acyl, acyloxy, sulfonyl, ureido, or carbamoyl, or alkyl, alkoxy, heteroalkyl, heteroalkoxy, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted.

US Pat. No. 10,188,671

BORON-DIPYRRIN COMPLEX AND MEDICAMENT CONTAINING THE SAME

JAPAN SCIENCE AND TECHNOL...

1. A boron-dipyrrin complex represented by formula (1)
wherein:
X1 represents a halogenoalkyl group;
X2 represents a halogen atom;
R1 represents a hydrogen atom, an alkyl group, or a group represented by formula (b):

R2 and R6 are the same or different and each represent a hydrogen atom or a halogen atom;
R3, R4, R5, and R7 are the same or different and each represent a hydrogen atom, a halogen atom, or an alkyl group;
R8 represents a hydrogen atom or —(CH2)l—(Y)m—(CH2)n—Z wherein Y represents —CO—, —CONH—, or a triazole ring, Z represents a carboxyl group, a sulfonic acid group, or a —CO— peptide residue, l and n each represent an integer of 1 to 6, and m represents 0 or 1;
R9 and R10 are the same or different and each represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; and
R8 and R10 together optionally form an alkylene group.

US Pat. No. 10,188,659

IGF-1R SIGNALING PATHWAY INHIBITORS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

YISSUM RESEARCH DEVELOPME...

1. A method of inhibiting toxic protein aggregation in a subject having a neurodegenerative disease selected from the group consisting of Amyloidosis, Prion disorders, Motor Neuron disease, Alzheimer's disease, Fronto temporal dementia 17 (FTD17), Huntington disease and Parkinson's disease, the method comprising the step of administering to the subject a therapeutically effective amount of a compound represented by the structure of formula I:
wherein
A is H or CN;
Z is S, SO or SO2;
X1, X2, X3, X4, X5, Y1 and Y2 are each independently selected from H, halogen, alkyl, haloalkyl and OR1; and
Y3 and Y4 are each OR1, wherein each R1 is independently H, C1-C4 alkyl, acyl, —(CH2CH2O)nH wherein n is an integer of 1 to 20, or a functional group that gives rise to hydroxyl upon hydrolysis,or salts, hydrates, and solvates thereof.

US Pat. No. 10,188,656

METHODS OF TREATMENT OF MALIGNANCIES

Agios Pharmaceuticals, In...

1. A method of treating acute myeloid leukemia in a subject comprising administering to the subject a mutant isocitrate dehydrogenase 2 (IDH2) inhibitor 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-[2-(trifluoromethyl)pyridin-4-yl]amino-1,3,5-triazin-2-yl)amino]propan-2-ol having the following formula:
or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein the acute myeloid leukemia is characterized by the presence of a mutant allele of IDH2 and the absence of a mutant allele of NRAS.

US Pat. No. 10,188,652

COMPOSITIONS AND METHODS FOR TREATING INSOMNIA

1. A method of treating insomnia, comprising administrating orally a dosage form comprising a therapeutically effective amount of compound A, wherein said therapeutically effective amount is a single daily dose ranging from about 2.5 mg to about 10 mg, wherein said single daily dose achieves a mean Cmax of from about 3.0 ng/ml to about 7.2 ng/ml for each 1 mg of compound A after administration to human subjects, and said compound A is (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide represented by the following formula:

US Pat. No. 10,188,651

METHODS OF TREATING SLEEP DISORDERS

Melior Pharmaceuticals II...

1. A method of treating a sleep disorder associated with altered sleep rhythm and/or architecture in a mammal comprising administering to the mammal in need thereof an effective amount of a compound of Formula Ia-1, Formula Ia-2, Formula Ib-1, Formula Ib-2, Formula Ic-1, Formula Ic-2, Formula Id-1, or Formula Id-2:or a pharmaceutically acceptable salt thereof, wherein the sleep disorder associated with altered sleep rhythm and/or architecture is insomnia, restless legs syndrome, narcolepsy, REM sleep behavior disorder, or disrupted circadian rhythm associated with sleep apnia, shift work, or jet lag; wherein:U is C;
each R1 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —N(?O)2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, or dialkylaminosulfinylalkyl, where r is 0, 1, 2, 3, 4, or 5;
each R2 and R3 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, dialkylaminosulfinylalkyl, aryl, or arylC1-C6alkyl, where n is 0, 1, 2, 3, or 4;
each R4 and R5 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, dialkylaminosulfinylalkyl, aryl, or arylC1-C6alkyl, where p is 0, 1, 2, 3, or 4;
W is H or C1-C6alkyl;
Y is H, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, or dialkylamino sulfinylalkyl;
X is O or S;
Z is O or S;
R7 is H or halo;
Q is H, C1-C6alkyl, aryl, C1-C6alkylaryl, C3-C6cycloalkyl, or heteroaryl, each of which is optionally substituted with —(R6)t, where t is 0, 1, 2, 3, 4, or 5;
R8 is H or C1-C6alkyl; and
each R6 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —N(?O)2, —C(?O)OH, —NH2, —CF3, —O—S(?O)2OH, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, —C(?O) C1-C6alkyl, —C(?O) C1-C6alkoxy, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, or dialkylaminosulfinylalkyl; or pharmaceutically acceptable salt thereof.

US Pat. No. 10,188,644

PROCESS OF MAKING STABLE ABUSE-DETERRENT ORAL FORMULATIONS

COLLEGIUM PHARMACEUTICAL,...

1. A pharmaceutical composition comprising solid microparticles or formulated microparticles prepared by:a. preparing a mixture comprising:
(i) oxycodone, myristic acid, beeswax and carnauba wax, or
(ii) oxycodone in the form of a fatty acid salt, beeswax and carnauba wax at a temperature sufficient to form a substantially homogeneous melt;
b. forming solid microparticles from the substantially homogeneous melt;
c. optionally further formulating the solid microparticles with additional pharmaceutically acceptable excipients to provide formulated microparticles, and
d. curing the solid microparticles or the formulated microparticles at a temperature within the range of 25° C. up to and including the inversion temperature, for a minimum of about 48 hours to provide cured solid microparticles or cured formulated microparticles;
wherein the solid microparticles or the formulated microparticles are cured at a first temperature above the inversion temperature and subsequently a second temperature below the inversion temperature.

US Pat. No. 10,188,642

PHARMACOLOGICALLY ACTIVE COMPOUNDS

Cancer Research Technolog...

1. A compound having the structural formula II shown below:
wherein:
X is CH or N;
Y is N or C—H;
R2 is (1-6C)alkyl, (1-8C)heteroalkyl, aryl, aryl(1-2C)alkyl, a 5 or 6 membered heteroaryl, a 5 or 6 membered heteroaryl(1-2C)alkyl, a 3 to 6 membered heterocyclyl, a 3 to 6 membered heterocyclyl(1-2C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl(1-2C)alkyl, C(O)R13, C(O)OR13, OC(O)R13, C(O)N(R14)R13, S(O)xR13 (where x is 0, 1 or 2), or SO2N(R14)R13;
and wherein R2 is optionally substituted by one or more substituent groups selected from fluoro, chloro, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, (1-4C)alkyl, (1-4C)alkoxy, S(O)xCH3 (where x is 0, 1 or 2), methylamino or dimethylamino, aryl, aryl(1-2C)alkyl, heteroaryl, heteroaryl(1-2C)alkyl, heterocyclyl, heterocyclyl(1-2C)alkyl, (3-8C)cycloalkyl, and (3-8C)cycloalkyl(1-2C)alkyl,
and wherein any (1-4C)alkyl, (1-4C)alkoxy, aryl, heteroaryl, heterocyclyl, or (3-8C)cycloalkyl moiety present within a substituent group on R2 is optionally further substituted by fluoro, chloro, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, (1-4C)alkyl, NRcRd, ORc, C(O)Rc, C(O)ORc, OC(O)Rc, N(Rd)ORc, C(O)N(Rd)Rc, N(Rd)C(O)Rc, S(O)yRc (where y is 0, 1 or 2), SO2N(Rd)Rc, or N(Rd)SO2Rc, wherein Rc and Rd are each independently H or (1-4C)alkyl;
R3 is hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl, halo, CF3, CN or (1-4C)alkoxy;
R4 is hydrogen, fluoro, chloro or CF3;
Ar has the formula:

wherein:
(i) all of A1, A2 and A3 are CH; or
(ii) A3 is CH and A1 or A2 are N or CH;
R5 is cyano, (1-3C)alkyl, (1-3C)fluoroalkyl, (1-3C)alkoxy, (1-3C)fluoroalkoxy, halo, (1-3C)alkanoyl, C(O)NR15R16 or S(O)2NR15R16, and wherein R15 and R16 are each independently H or (1-3C)alkyl, and wherein any alkyl or alkoxy moities present within a R5 substituent group are optionally further substituted by hydroxy or methoxy;
R6 is halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, ureido, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl,
or R6 is a group of the formula:
-L1-L2-R17
wherein
L1 is absent or a linker group of the formula —[CR18R19]n— in which n is an integer selected from 1, 2, 3 and 4, and R18 and R19 are each independently hydrogen or (1-2C)alkyl;
L2 is absent or is O, S, SO, SO2, N(R20), C(O), C(O)O, OC(O), CH(OR20), C(O)N(R20), N(R20)C(O), N(R20)C(O)N(R21), S(O)2N(R20), or N(R21)SO2, wherein R20 and R21 are each independently selected from hydrogen or (1-2C)alkyl; and
R17 is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl, or heterocyclyl-(1-4C)alkyl,
 and wherein R17 is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, nitro, hydroxy, NR22R23, (1-4C)alkoxy, (1-4C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-3C)alkyl, (1-5C)alkanoyl, (1-5C)alkylsulphonyl, heterocyclyl, heterocyclyl-(1-2C)alkyl, heteroaryl, heteroaryl-(1-2C)alkyl, CONR22R23, and SO2NR22R23; wherein R22 and R23 are each independently selected from hydrogen, (1-4C)alkyl or (3-6C)cycloalkyl or (3-6C)cycloalkyl(1-2C)alkyl; or R22 and R23 can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-6 membered heterocyclic ring ring;
 and wherein when said substituent group comprises an alkyl, cycloalkyl, heterocyclyl or heteroaryl moiety then said moiety is optionally further substituted by hydroxy, fluoro, chloro, cyano, CF3, OCF3, (1-2C)alkyl, (1-2C)alkoxy, SO2(1-2C)alkyl or NReRf (where Re and Rf are each independently hydrogen, (1-3C)alkyl, (3-6C)cycloalkyl, or (3-6C)cycloalkyl(1-2C)alkyl);
or R17 is a group having the formula:
-L3-L4-R24
wherein
L3 is absent or a linker group of the formula —[CR25R26]n— in which n is an integer selected from 1, 2, 3 or 4, and R25 and R26 are each independently hydrogen or (1-2C)alkyl;
L4 is absent or is O, S, SO, SO2, N(R27), C(O), C(O)O, OC(O), CH(OR27), C(O)N(R27), N(R27)C(O), N(R27)C(O)N(R28), S(O)2N(R27), or N(R28)SO2, wherein R27 and R28 are each independently hydrogen or (1-2C)alkyl; and
R24 is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl, or heterocyclyl-(1-4C)alkyl;
R13 is hydrogen, (1-6C)alkyl, (1-6C)alkoxy, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-2C)alkyl, aryl, aryl-(1-2C)alkyl, heteroaryl, or heteroaryl-(1-2C)alkyl, and wherein R13 is optionally further substituted by one or more substituents selected from hydroxy, fluoro, chloro, cyano, CF3, OCF3 (1-2C)alkyl and (1-2C)alkoxy;
R14 is hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, or (3-6C)cycloalkyl-(1-2C)alkyl, and wherein R14 is optionally further substituted by one or more substituents selected from hydroxy, fluoro, chloro, cyano, CF3, OCF3, (1-2C)alkyl and (1-2C)alkoxy;
subject to the proviso that:
X can only be N when Y is N;
when X and Y are both N, R3 is H or fluoro;
or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,188,639

METHODS OF TREATING NEUROLOGICAL, METABOLIC, AND OTHER DISORDERS USING ENANTIOPURE DEUTERIUM-ENRICHED PIOGLITAZONE

DeuteRx, LLC, Andover, M...

1. A method of treating a neurological disorder selected from the group consisting of Parkinson's disease, amyotrophic lateral sclerosis, Friedreich's ataxia, autism spectrum disorder, depression, mild cognitive impairment, Down syndrome, neurodegeneration, adrenoleukodystrophy, Huntington's disease, substance abuse, neuronal injury, and major depression or bipolar disorder cormorbid with metabolic syndrome, comprising administering to a patient in need thereof a therapeutically effective amount of a deuterium-enriched compound of Formula I having an optical purity of at least 75% enantiomeric excess to treat the neurological disorder, wherein Formula I is represented by:
or a pharmaceutically acceptable salt thereof, wherein:
A1, A2, A3, and A4 are independently —C(R9)(R10)—;
A5 is —C(R11)(R12)(R13);
R1, R2, R3, R4, R5, R6, R7, and R8 are independently H or D;
R9, R10, R11, R12, and R13 each represent independently for each occurrence H or D; and
Z is H or D, provided that the abundance of deuterium in Z is at least 30.

US Pat. No. 10,188,638

COMPOUNDS AND COMPOSITIONS FOR INDUCING CHONDROGENESIS

Novartis AG, Basel (CH)

1. A method of treating osteoarthritis or rheumatoid arthritis in a mammal in need thereof, comprising administering to a joint of the mammal a therapeutically effective amount of a compound of Formula IA:or a pharmaceutically acceptable salt, or stereoisomer thereof; wherein“ ”represents a single or double bond;
R0 is selected from hydrogen and C1-6alkyl;
R1 is selected from cyano, 6-membered heterocycloalkyl, 6-membered heterocyclyl, phenyl, and 5- to 9-membered heteroaryl, wherein
the heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R1 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C1-6alkyl, C1-6haloalkyl, —C(O)R13, —C(O)O R13, —NR14aR14b5- and 6-membered heterocycloalkyl, phenyl, and 5- and 6-membered heteroaryl; wherein
R13 is selected from C1-6alkyl, amino, and C1-6alkylamino;
R14a and R14b are each independently selected from hydrogen, C1-6alkyl, —C(O)R15, —C(O)OR15, and —S(O)2R15, wherein R15 is hydrogen or C1-6alkyl; and
the heterocycloalkyl, phenyl or heteroaryl substituent of R1 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, hydroxy, C1-6alkyl, and C1-6haloalkyl,
R3 is selected from C1-6alkyl, C1-6haloalkyl, 5- and 6-membered cycloalkyl, 5- and 6-membered heterocycloalkyl, 6- and 10-membered heterocyclyl, phenyl, and 5- and 6- membered heteroaryl, wherein
the cycloalkyl, heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R3 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C1-6alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6haloalkoxy, —C(O)R16, —C(O)OR16, - S (O)2R16, 5- and 6-membered heterocycloalkyl, and phenyl; wherein
R16 is hydrogen or C1-6alkyl;
the phenyl or heterocycloalkyl substituent of R3 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, and cyano; and
R2 and R4 are each hydrogen or C1-6alkyl; or R2 and R4 taken together form a cyclopropyl ring fused to the bicyclic ring; or R2 and R4 taken together form a bond producing a double bond between the two carbons to which R2 and R4 are attached;
each R5 and R10 is independently hydrogen or C1-6alkyl; or R5 and R10 taken with the atoms to which they are linked form a 5- or 6-membered ring fused to the bicyclic ring; and
R6 and R7 are each hydrogen or C1-6alkyl; or R6 and R7 taken together form a bond producing a double bond between the two carbons to which R6 and R7 are attached;
thereby treating osteoarthritis or rheumatoid arthritis in the mammal.

US Pat. No. 10,188,635

USE OF GABOXADOL IN THE TREATMENT OF TINNITUS

OVID THERAPEUTICS INC., ...

1. A method of treating tinnitus comprising administering to a patient in need thereof about 0.05 mg to about 30 mg gaboxadol or a pharmaceutically acceptable salt thereof, wherein the method provides improvement in one or more symptoms of tinnitus in the patient and the improvement is provided for more than 6 hours after administration.

US Pat. No. 10,188,634

3-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1 H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF

Samumed, LLC, San Diego,...

1. A compound, or a pharmaceutically acceptable salt thereof, of Formula I:
wherein:
R1 and R2 are independently selected from the group consisting of H and halide;
R3 is selected from the group consisting of heteroaryl optionally substituted with 1-4 R6 and -heterocyclyl optionally substituted with 1-10 R7;
R5 is selected from the group consisting of heteroaryl optionally substituted with 1-4 R8, -heterocyclyl optionally substituted with 1-10 R9, and -aryl optionally substituted with 1-5 R10;
each R6 is independently selected from the group consisting of halide, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R11, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R11, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R11, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C2-4 alkenylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C2-4 alkynylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C1-4 alkylene)paryl optionally substituted with 1-5 R13, —(C2-4 alkenylene)paryl optionally substituted with 1-5 R13, —(C2-4 alkynylene)paryl optionally substituted with 1-5 R13, —NHC(?O)R14, —NR15R16, —(C1-6 alkylene)NR17R18, —(C2-6 alkenylene)NR17R18, —(C2-6 alkynylene)NR17R18, and —(C1-4 alkylene)pOR24;
each R7 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R8 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —OCH3, —CN, and —C(?O)R19;
each R9 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —CN, and —OCH3;
each R10 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —CN, —(C1-6 alkylene)pNHSO2R19, —(C2-6 alkenylene)pNHSO2R19, —(C2-6 alkynylene)pNHSO2R19, —NR15(C1-6 alkylene)NR15R16, —NR15(C2-6 alkenylene)NR15R16, —NR15(C2-6 alkynylene)NR15R16, —(C1-6 alkylene)pNR15R16, —(C2-6 alkenylene)pNR15R16, —(C2-6 alkynylene)pNR15R16, and —OR27;
each R11 is independently selected from the group consisting of amino, —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R12 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R13 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R14 is independently selected from the group consisting of —(C1-9 alkyl), —(C1-4 haloalkyl), —(C2-9 alkenyl), —(C2-9 alkynyl), -heteroaryl optionally substituted with 1-4 R20, -aryl optionally substituted with 1-5 R21, —CH2aryl optionally substituted with 1-5 R21, -carbocyclyl optionally substituted with 1-12 R22, —CH2carbocyclyl optionally substituted with 1-12 R22, —(C1-4 alkylene)pNR25R26, (C2-4 alkenylene)pNR25R26, —(C2-4 alkynylene)pNR25R26, -heterocyclyl optionally substituted with 1-10 R23, and —CH2heterocyclyl optionally substituted with 1-10 R23;
each R15 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R16 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —CH2aryl optionally substituted with 1-5 R21, and —CH2carbocyclyl optionally substituted with 1-12 R22;
each R17 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R18 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —CH2aryl optionally substituted with 1-5 R21, and —CH2carbocyclyl optionally substituted with 1-12 R22;
each R19 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R20 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R21 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R22 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R23 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
R24 is selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R23, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C2-4 alkenylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C2-4 alkynylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C1-4 alkylene)paryl optionally substituted with 1-5 R21, —(C2-4 alkenylene)paryl optionally substituted with 1-5 R21, —(C2-4 alkynylene)paryl optionally substituted with 1-5 R21, —(C1-6 alkylene)pNR25R26, (C2-4 alkenylene)pNR25R26, and (C2-4 alkynylene)pNR25R26;
each R25 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R26 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
R27 is selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R23, —(C1-6 alkylene)pNR25R26, —(C2-6 alkenylene)pNR25R26, and —(C2-6 alkynylene)pNR25R26; and
each p is independently an integer of 0 or 1.

US Pat. No. 10,188,629

PRODRUG OF GREEN TEA EPIGALLOCATECHIN-3-GALLATE (PRO-EGCG) FOR USE IN THE TREATMENT OF ENDOMETRIOSIS

1. A method of treating endometriosis or a related indication comprising administering to a subject in need thereof, via enteral or intraperitoneal administration, or an injection into the vagina or uterine cavity, an effective amount of Pro-EGCG having the formula:

US Pat. No. 10,188,625

COMBINATION OF A RETINOID AND A DIOL AND POLYUNSATURATED FATTY ACID ESTER

PIERRE FABRE DERMO-COSMET...

1. A combination comprising a retinoid and a compound of the following general formula (I):wherein:n is an integer between 0 and 15,
m is 0, 1, 2 or 3, and
R is the hydrocarbon chain of a polyunsaturated fatty acid selected from omega-3s and omega-6s.

US Pat. No. 10,188,623

ENHANCED BIOAVAILABILITY OF POLYUNSATURATED FATTY ACIDS

Patheon Signals Inc., Hi...

1. An oral pharmaceutical composition comprising an enteric soft capsule shell comprising gelatin and an enteric polymerwherein a weight ratio of the enteric polymer and gelatin is 1:2.6; and
wherein the shell encapsulates a matrix fill comprising at least 94% by weight eicosapentaenoic free fatty acid (EPA) and less than 1% by weight docosahexaenoic acid (DHA).

US Pat. No. 10,188,622

USE OF A COMPOSITION COMPRISING FISH OIL AND JUICE FOR THE TREATMENT AND/OR POST TREATMENT OF CANCER

Smartfish AS, Oslo (NO)

1. A method for treatment and/or post treatment of cancer in a subject in need of treatment thereof, the method comprising administering to the subject a therapeutically effective amount of a composition comprising:a combination of fish oil, and
juice in an oil-in water emulsion,
wherein the fish oil has a totox value below 20 and an omega-3 content above 10% by weight based on the total weight of the fish oil and wherein a suitable emulsifier is used to stabilize the emulsion,
wherein the cancer is selected from the group consisting of prostate cancer, lung cancer, and skin cancer and the post treatment of cancer comprises treatment of cachexia, vitamin D deficiency, fatigue, or stimulation of the immune system, and
wherein said suitable emulsifier is selected from the following group consisting of milk solids, whey protein, oat protein, and pea protein.

US Pat. No. 10,188,618

TREATMENT OF CANCER WITH SPECIFIC RXR AGONISTS

IO Therapeutics, Inc., S...

1. A method of treating a hematologic malignancy, wherein the hematologic malignancy is a leukemia or a lymphoma, comprising administering to a patient in need of such treatment a retinoid X receptor (RXR) agonist at a dose below its Retinoic Acid Receptor (RAR) activating threshold and at or above its RXR effective dose, the RXR agonist has a chemical structure
where R is H, lower alkyl or 1 to 6 carbons, or a pharmaceutically acceptable salt of the compound, and the dose of the RXR agonist is from about 0.1 to about 20 mg/m2/day.

US Pat. No. 10,188,610

PROLONGED-RELEASE DIPHENIDOL COMPOSITION

INVEKRA, S.A.P.I. DE C.V....

1. A sustained release diphenidol single layer tablet, consisting of: a) from 15 to 50% diphenidol hydrochloride; b) from 0.1 to 20% of one or more binding agents; c) from 5 to 90% of one or more diluent agents; d) from 5 to 50% of one or more release modification agents; e) from 0.25 to 10% of one or more lubricating agents; and f) 0.1 to 10% of one or more gliding agents, wherein all of the ingredients of the tablet are mixed together prior to tabletting.

US Pat. No. 10,188,608

OXIDIZED CELLULOSE MICROSPHERES

Covidien LP, Mansfield, ...

1. A process for forming microspheres comprising:forming a first plurality of microspheres including at least one bioactive agent and oxidized cellulose;
contacting the first plurality of microspheres with a solution of an aliphatic polyester to form a discontinuous phase liquid;
contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and
extracting a second plurality of microspheres from the emulsion, the second plurality of microspheres including one or more microspheres of the first plurality of microspheres at least partially encapsulated in the aliphatic polyester.

US Pat. No. 10,188,606

EXPANSILE CROSSLINKED POLYMERSOME FOR PH-SENSITIVE DELIVERY OF ANTICANCER DRUGS

Mayo Foundation for Medic...

1. A polymer of Formula (I):
wherein:
each R is independently C1-6 alkyl; and
n is an integer between 1 and 50.

US Pat. No. 10,188,602

BIOERODIBLE IMPLANT FOR LONG-TERM DRUG DELIVERY AND ASSOCIATED METHODS OF MANUFACTURE AND USE

GESEA BIOSCIENCES INC., ...

1. A method for making a core-and-shell type of pellet for controlled release of a pharmacologically active agent, the method comprising:(a) providing (i) an elongated pin comprising two axially aligned, substantially cylindrical adjacent segments of different diameters, with a wider lower segment and a narrower upper segment that terminates in a pin tip, (ii) a pelleting tube having an upper tube opening, an opposing lower tube opening, an inner surface, and an inner diameter sized to provide a sealing fit between the inner surface and the lower segment of the pin, and (iii) a funnel having an outlet aligned with the upper tube opening;
(b) inserting the pin tip into the lower tube opening and moving the pin upward through the tube toward the funnel until the pin tip and upper pin segment protrude from the upper tube opening into the funnel, thereby bringing the lower segment within the tube;
(c) placing a molten shell composition in the funnel;
(d) gradually withdrawing the lower segment from the tube, thereby lowering the upper segment into the tube and simultaneously drawing the shell composition into a concentric space between the upper segment and the inner surface of the tube;
(e) allowing the shell composition to cool and thereby harden into a shell formed around the upper segment within the concentric space;
(f) placing a molten core composition into the funnel; and
(g) gradually lowering the upper segment within the tube, thereby drawing the core composition into the shell to form a core,
wherein the shell composition and/or core composition contain a pharmacologically active agent.

US Pat. No. 10,188,597

HAIR COLOR STAIN REMOVER AND METHOD OF USE

1. A hair color stain remover formula, comprising by volume:a) about 67.9999% Witch Hazel Extract;
b) about 20.0% Glycerin;
c) about 8.8% Distilled Water;
d) about 3.0% Sodium Cocoyl Glycinate;
e) about 0.1% Potassium Sorbate;
f) about 0.1% Sodium Benzoate; and
g) about 0.0001% Green Tea Extract.