US Pat. No. 10,478,029

EXHAUST-SUPPLIED VACUUM SYSTEM AND APPARATUS

Lockheed Martin Corporati...

1. A system, comprising:a tool comprising an exhaust port; and
a vacuum comprising:
an exhaust intake port configured to couple to the exhaust port of the tool, wherein the exhaust intake port is configured to receive exhaust from the exhaust port;
a vacuum intake port comprising a nozzle, the nozzle comprising a first end and a second end opposite the first end, the nozzle comprising a cross-sectional area that decreases in a direction from the first end towards the second end;
a plurality of threads at least partially surrounding the nozzle;
a vacuum exhaust port opposite the vacuum intake port; and
a mixing chamber between the vacuum intake port and the vacuum exhaust port; and
a suction piece configured to couple to the vacuum intake port via a flexible hose, the suction piece comprising a nose piece configured to encircle a portion of the tool;
wherein:
the vacuum intake port, the vacuum exhaust port, and the mixing chamber are all on a same centerline;
the second end of the nozzle is coupled to an end of the mixing chamber that is opposite the vacuum exhaust port; and
the plurality of threads that at least partially surround the nozzle are configured to couple the flexible hose to the vacuum intake port.

US Pat. No. 10,478,028

RECHARGEABLE VACUUM CLEANER ASSEMBLY

JIANGSU MIDEA CLEANING AP...

1. A rechargeable vacuum cleaner assembly, comprising:a rechargeable vacuum cleaner provided with a first magnetic member;
a charging stand provided with a second magnetic member, wherein the first magnetic member is configured to connect with the second magnetic member through magnetic attraction so as to position the rechargeable vacuum cleaner to the charging stand;
a pedal disposed on body of the charging stand and pivotable between a first position and a second position; and
a safety protection device disposed on body of the charging stand and normally engaged with the pedal, wherein when the safety protection device is toggled, the safety protection device is disengaged from the pedal to make the pedal move from the first position to the second position, wherein at least two safety protection devices are provided; the at least two safety protection devices are disposed on the body and spaced apart from each other; when the at least two safety protection devices are toggled, the at least two safety protection devices are disengaged from the pedal to make the pedal move from the first position to the second position;
wherein each safety protection device comprises:
a safety protection member disposed at a side face of the pedal and defining an fitting groove in which an edge of the pedal is fitted; and
a resetting member disposed between the safety protection member and the body, and configured to normally push the safety protection member towards a center of the pedal, wherein the safety protection member is pivotably connected to the body;
wherein the safety protection member has a first end and a second end, in which the fitting groove is defined in the second end of the safety protection member; when the first end of the safety protection member is toggled, the second end of the safety protection member moves away from the center of the pedal to disengage the edge of the pedal from the fitting groove;
wherein the first end of the safety protection member has a guide surface configured to toggle the first end of the safety protection member,
wherein the guide surface is constructed to extend obliquely towards the center of the pedal from up to down; and
wherein the guide surface is formed as an oblique plane or an oblique curved surface, extending obliquely towards the center of the pedal from up to down.

US Pat. No. 10,478,025

TOILET TRAINING DEVICES FOR SMALL CHILDREN

Munchkin, Inc., Van Nuys...

1. A toilet training device, comprising:a seat assembly comprising:
a lid; and
a seat having a central opening;
a portable main body portion having a shell with an interior space housing a removable waste bin, and adapted to support the seat assembly thereon;
a substantially round blind recess defined in the lid and positioned directly over and in direct communication with the central opening of the seat; and
a self-contained odor remediating insert that is completely enclosed and permanently contained by a housing having an upper portion with a plurality of ventilation holes defined therein, and a lower portion permanently attached to the upper portion wherein the lower surface of the housing of the self-contained odor remediating insert is releasably received by an interference fit with raised ribs defined in at least one side wall of the blind recess upon finger-pressing the housing of the self-contained odor remediating insert perpendicularly into the blind recess.

US Pat. No. 10,478,016

GAS-FIRED SMOKER WITH DIGITAL TEMPERATURE CONTROL

Masterbuilt Manufacturing...

1. A gas-fired smoker for cooking a food product using a smoking process comprising:a. a cabinet with a top, a bottom, sides, a back, an access door, and at least one rack vertically located within the cabinet for holding the food product to be cooked;
b. a gas burner located adjacent the bottom and connected to a source of flammable gas by means of a gas valve;
c. a pilot light for igniting the flammable gas at the gas burner; and
d. a control circuit including:
i. a controller;
ii. a DC power source for powering the control circuit including the controller;
iii. a temperature set module connected to the controller for setting a cabinet temperature value for the cabinet temperature inside the cabinet;
iv. a temperature sensor connected to the controller for sensing the cabinet temperature inside the cabinet, wherein the temperature sensor is located in the cabinet at a position representative of the average temperature within the cabinet based on averaging a plurality of different temperatures measured in the cabinet;
v. a display connected to the controller;
vi. wherein the controller:
(a) in response to sensing the cabinet temperature and based on the cabinet temperature value set by the temperature set module, controls the gas valve to start the gas burner and to extinguish the gas burner in order to maintain a range of cabinet temperatures related to the cabinet temperature value set by the temperature set module; and
(b) controls the display to display parameters selected from the cabinet temperature inside the cabinet, status of the gas burner, status of the pilot light, status of the source of flammable gas, or status of the DC power source.

US Pat. No. 10,478,014

SEMI AUTOMATIC COLLAPSIBLE CHAFER WITH HEATER SUPPORTS

1. A collapsible chafing dish system comprising:at least one rectangular frame having a first horizontally extending arm, a second horizontally extending arm, a third horizontally extending arm and a fourth horizontally extending arm, whereby the first and third arms are longer than the second and fourth arms,
the first arm comprises a first arm segment and a second arm segment, the second arm comprises a third and fourth arm segment, the third arm comprises a fifth and sixth arm segment, and the fourth arm comprises a seventh and eight arm segment, whereby each of the arm segments comprises a first end and a second end,
the second end of the first arm segment being joined to the first end of the second arm segment by a first truss connector, the second end of the third arm segment being joined to the first end of the fourth arm segment by a second truss connector, the second end of the fifth arm segment being joined to the first end of the sixth arm segment by a third truss connector, the second end of the seventh arm segment being joined to the first end of the eighth arm segment by a fourth truss connector,
the first end of the first arm segment being joined to the first end of the eight arm segment by a first hinge, the second end of the second arm segment being joined to the first end of the third arm segment by a second hinge, the second end of the fifth arm segment being joined to the second end of the fourth arm segment by a third hinge, and the first end of the sixth arm segment being joined to the second end of the seventh arm segment by a fourth hinge,
a hole is located within the second hinge which is adapted to support a thermometer,
a first, second third, and fourth leg member, each of the leg members being comprised of an inner and outer leg element, whereby each outer leg element comprises a first end and a second end, and each of the inner leg elements comprises a first end and a second end, whereby the first end of each inner leg element is inserted within the second end of the respective outer leg segment, such that the leg segments can be used to adjust a height of the system relative to a supporting surface,
the first end of the outer leg segment of the first leg member being joined to the first hinge, the first end of the outer leg segment of the second leg member being joined to the second hinge, the first end of the outer leg segment of the third leg member being joined to the third hinge, and the first end of the outer leg segment of the fourth leg member being joined to the fourth hinge,
the second end of each inner member comprising a foot press with a bottom end adapted to rest on the supporting surface,
a chafing dish holding area defined within the rectangular frame and the leg members, whereby a chafing dish can be placed between the horizontally extending arms,
a first diagonal brace member is connected between the first arm segment and the outer leg segment of the first leg member, a second diagonal brace member is connected between the second arm segment and the outer leg segment of the second leg member, a third diagonal brace member is connected between the fifth arm segment and the outer leg segment of the third leg member, and a fourth diagonal brace member is connected between the sixth arm segment and the outer leg segment of the fourth leg member,
at least one burner support adapted to hold a heating source which supplies heat to the chafing dish, whereby the at least one burner support is connected to the first and fourth leg members or the second and third leg members,
wherein the chafing dish system can be moved between a collapsed position and an expanded position,
such that when in the expanded position a chafing dish can be placed with the chafing dish holding area, and a horizontal plane is defined along and between the arms, and
when in the collapsed position, the arm segments are pivoted about the truss connectors and hinges, to move the second leg member adjacent the first leg member and the third leg member adjacent the fourth leg member, and whereby the truss connectors are located below the horizontal plane.

US Pat. No. 10,478,009

BEVERAGE INFUSION SYSTEM

1. A beverage infusion system comprising:an infusion chamber configured to hold an infusing material and to allow a beverage to flow through the infusion chamber past the infusing material such that the beverage is infused by the infusing material, wherein the infusion chamber is formed by:
an outer housing having a first end and a second end and openings formed at each end,
a first enclosure member configured to removably mount to the first end of the outer housing and to cover the opening located at the first end of the outer housing, and
a second enclosure member configured to removably mount to the second end of the outer housing and to cover the opening located at the second end of the outer housing;
a beverage inlet in fluid communication with the infusion chamber for carrying the beverage to the infusion chamber;
a beverage outlet in fluid communication with the infusion chamber for carrying the beverage to away from the infusion chamber;
a heat transfer probe inside the infusion chamber and positioned such that the beverage entering the infusion chamber via the beverage inlet and exiting via the beverage outlet flows past the heat transfer probe;
a coolant path operable for carrying a coolant through the heat transfer probe,
wherein, when the coolant is at a lower temperature than the beverage flowing through the infusion chamber, heat is carried away from the beverage and is transferred through the coolant probe to the coolant as the beverage flows past the coolant probe,
wherein the infusion chamber maintains pressure of the beverage passing through it, such that the pressure of the beverage at the beverage outlet is substantially equal to the pressure of the beverage at the beverage inlet, and
wherein the beverage infusion system further comprising a first filter configured to removably mount between the first enclosure member and the outer housing, such that the first filter covers the opening located at the first end of the outer housing and is positioned between the beverage inlet and the infusion chamber.

US Pat. No. 10,478,008

MACHINE FOR PREPARING BEVERAGES COMPRISING AN OPENING DISPOSITION AND PROCESS FOR PREPARING A BEVERAGE WITH ANTICIPATED OPENING

1. A beverage preparation machine (1) adapted for preparing beverages from single doses of at least one edible substance provided in a strip of linked single dose packages (2), said packages (2) comprising a support (21) carrying a plurality of single dose portions (22), each single dose portion comprising at least one first and one second package walls (23, 24) sealed so as to be substantially air tight, whereby said machine (1) comprises:at least one extraction device (3) adapted so that said at least one extraction device can collect one of said single dose packages (2) from said strip inside thereof,
an opening device (5) disposed upstream of said extraction device (3) along the supply direction of said strip, and adapted so as to provide a plurality of passageways (25) in at least one of said first and second package walls (23, 24) of said single dose portions (22),
wherein said opening device (5) comprises at least one opening part (51, 52) that presents a plurality of opening protrusions (53) disposed along a respective perimeter surface and adapted so as to provide said plurality of passageways (25), and
wherein said opening part (51, 52) is provided so that said opening part can be actuated in rotation around a substantially horizontal or vertical axis and disposed so that said opening part can produce said passageways (25).

US Pat. No. 10,478,005

STEAM GENERATING APPARATUS AND HEATING COOKER

SHARP KABUSHIKI KAISHA, ...

1. A steam generating apparatus comprising:a steam generator, the steam generator including a housing capable of storing water therein, and a heating unit for heating the housing so as to generate steam;
a water level measurement unit for measuring a water level in the housing;
a water supply unit for supplying water into the housing; and
a controller for controlling the heating unit and the water supply unit,
the controller being configured to
when a time during which that the measured water level does not exceed a threshold value continues for a first time, control the water supply unit to start water supply into the housing, and
when the time during which the measured water level does not exceed the threshold value continues for a second time longer than the first time, control the heating unit to stop heating of the housing;
wherein the controller is further configured to
when the measured water level exceeds the threshold value, and thereafter, when a time during which the measured water level exceeds the threshold value continues for a third time, control the heating unit to start heating of the housing, and
when the time during which the measured water level exceeds the threshold value continues for a fourth time longer than the third time, control the water supply unit to stop the water supply into the housing.

US Pat. No. 10,478,003

TREE STAND

Polygroup Macau Limited (...

1. A Christmas tree system comprising:a Christmas tree; and
a tree stand including:
a body having:
a first concentric cylinder rotatably coupled with a second concentric cylinder, each of the first concentric cylinder and the second concentric cylinder comprising one or more holes; and
an adapter positioned proximate an end of the body;
one or more legs coupled to the first concentric cylinder;
one or more legs coupled to the second concentric cylinder; and
a spring-loaded locking mechanism configured to engage the one or more holes of the first and second concentric cylinders to secure a rotational alignment of the first concentric cylinder relative the second concentric cylinder, the spring-loaded locking mechanism including a spring and a detent having a base portion and a protruding portion,
wherein, when the spring-loaded locking mechanism is in a locked configuration corresponding to the rotational alignment of the first concentric cylinder relative the second concentric cylinder, the spring pushes the detent outward from a central axis of the first and second concentric cylinders such that the protruding portion extends at least partially through the holes of the first and second concentric cylinders and the base portion abuts an inner wall of the first concentric cylinder or the second concentric cylinder,
wherein, when the spring-loaded locking mechanism is in an unlocked configuration, the spring is compressed such that the base portion does not abut an inner wall of the first concentric cylinder or the second concentric cylinder and the protruding portion is located substantially within the inner wall of the first concentric cylinder and the second concentric cylinder, and
wherein at least one of the concentric cylinders is configured to receive a trunk of the Christmas tree.

US Pat. No. 10,477,998

DRINK CUP

Berry Plastics Corporatio...

1. A drink cup comprisesa body including a floor and a side wall coupled to the floor to extend along a central axis away from the floor to define an interior region configured to provide a fluid-holding reservoir,
a brim coupled to the body to locate the side wall between the brim and the floor and configured to define an opening into the interior region, and
a body-strengthening system coupled to the body between the floor and the brim and configured to increase rigidity of a selected portion of the drink cup when compared to a rigidity of the side wall of the drink cup without increasing a weight of the drink cup,
wherein the body-strengthening system includes a first strengthening unit located between a lower portion of the side wall and a middle portion of the side wall and a second strengthening unit located between the first strengthening unit and the brim,
wherein the first strengthening unit includes an upper-strengthening segment and a C-shaped lower-strengthening segment, the upper-strengthening segment is located between the C-shaped lower-strengthening segment and the middle portion of the side wall and the C-shaped lower-strengthening segment is located between the upper-strengthening segment and the lower portion of the side wall,
wherein the upper-strengthening segment is spaced apart from the central axis a first distance and the C-shaped lower-strengthening segment is spaced apart from the central axis a second distance and the second distance is greater than the first distance, and
wherein the second strengthening unit includes a C-shaped annular ring coupled to an upper portion of the side wall and an annular strip extending between and interconnecting the C-shaped annular ring and the middle portion of the side wall.

US Pat. No. 10,477,992

DISPLAY APPARATUS

Homemakers Plaza, Inc., ...

1. A display apparatus, comprising:a support frame having end members and cross bars that extend between the end members;
wherein the cross bars include upper and lower cross bars;
a plurality of arm support tubes connected to the support frame;
wherein the plurality of arm support tubes are connected to one of the lower cross bars at a first end and extend vertically and between the upper cross bars at a second end;
a plurality of support arms each having a vertical section and a horizontal section;
wherein the vertical section of each of the plurality of support arms receives one of the plurality of arm support tubes at one end, and the horizontal section extends from an opposite end of the vertical section and terminates in an end.

US Pat. No. 10,477,988

TAPE FOR MODULAR SHELF SYSTEM

WALMART APOLLO, LLC, Ben...

1. A modular shelf organization system for a gondola rack, the modular shelf organization system comprising:a first marking member adapted to adhere to a vertical plane of a gondola rack, wherein the vertical plane comprises a first plurality of notches arranged in a vertical line along the vertical plane and includes a first sensor trigger element;
the first marking member comprising one or more identifiers located on a longitudinal surface of the first marking member such that when the first marking member is adhered to the vertical plane, each identifier is located adjacent to one of the first plurality of notches;
a second plurality of notches arranged in a vertical line along the vertical plane; and a second marking member adapted to adhere to the vertical plane, the second marking member comprising a second sensor trigger element and one or more identifiers located on a longitudinal surface of the marking member such that when the marking member is adhered to the vertical plane, each identifier is located adjacent to one of the second plurality of notches; and
a shelf connected to the one of the first plurality of notches and one of the second plurality of notches to complete a connection between the first sensor trigger element and the second sensor trigger element to indicate that the shelf is correctly placed.

US Pat. No. 10,477,985

REFRIGERATION DISPLAY CASES WITH IMPROVED COIL COVERS

Kysor Warren EPTA US Corp...

1. A refrigeration display case for refrigerating and displaying perishable goods, the refrigeration display case comprising:a base member;
a back wall coupled to the base member; a top member coupled to the back wall;
the base member, back wall, and top member forming an interior display area in which the perishable goods are displayed;
the base member comprising:
at least one fan plenum associated with at least one fan,
a plurality of evaporator coils have a top portion and a bottom portion, a coil cover, and
wherein the at least one fan plenum and at least one fan are configured to direct air over the plurality of evaporator coils; and
wherein the coil cover comprises:
a planar member having a first end, a second end, a first side end, and a second side end, the planar member covering a portion of the top portion of the plurality of evaporator coils,
an attachment member coupled to the second end of the planar member for coupling the planar member to the base member or back wall,
a living hinge formed in the planar member and extending from the first side end to the second side end, wherein a first portion of the planar member may rotate or move to an angle greater than 45 degrees relative to a second portion of the planar member.

US Pat. No. 10,477,977

ELECTRIC MOTOR DRIVEN ADJUSTABLE MATTRESS

1. An electric motor driven adjustable mattress, comprising:a) having a shared casing in which at least one flat cushion element of a cushion structure and an electric motor driven adjustable support apparatus for supporting the cushion element are accommodated;
b) the support apparatus has at least two support parts that are adjustable relative to one another, and that on their sides facing the cushion element are provided with spring elements for elastically resiliently supporting the cushion element;
c) wherein for adjusting the support parts relative to one another, at least one electric motor driven drive apparatus is accommodated in the shared casing,
d) wherein in each case two support parts of the support apparatus that are adjustable relative to one another are connected to one another via a pivot axis; and
e) wherein the support apparatus has at least two bending and folding axes that are spaced apart from one another along the longitudinal direction of the support apparatus and that are situated in such a way that for folding the mattress, the support parts together with the cushion element or cushion elements situated thereon may be folded together, and in the folded state the extension of the mattress in its longitudinal direction is smaller than in the unfolded state.

US Pat. No. 10,477,975

MATTRESS WITH COMBINATION OF PRESSURE REDISTRIBUTION AND INTERNAL AIR FLOW GUIDES

FXI, Inc., Media, PA (US...

1. A body support system, comprising:a base defining a length and a width and a longitudinal axis;
a first breathing layer disposed over the base, said first breathing layer defining multiple rows of cellular polymer material, wherein cellular polymer material forming at least two rows has air permeability of at least 5 ft3/ft2/min, with said at least two rows spaced apart from one another by a row of a different cellular polymer material having an air permeability below 5 ft3/ft2/min;
a second breathing layer disposed over the first breathing layer, said second breathing layer defining multiple rows of cellular polymer material, wherein cellular polymer material forming at least two rows has air permeability of at least 5 ft3/ft2/min, with said at least two rows spaced apart from one another by a row of a different cellular polymer material having an air permeability below 5 ft3/ft2/min, and wherein a first one of the at least two rows of said second breathing layer is positioned over and in staggered relation to a first row of the at least two rows of the first breathing layer to define a first air flow path through the first row of the second breathing layer and the first row of the first breathing layer that is disposed at an angle offset from vertical, and wherein a second row of the at least two rows of said second breathing layer is positioned over and in staggered relation to a second row of the at least two rows of the first breathing layer to define a second air flow path through the second row of the second breathing layer and the second row of the first breathing layer that is disposed at an angle offset from vertical;
a porous bridge having air permeability of at least 5 ft3/ft2/min positioned in the base and in contact with the first breathing layer; and
at least one air flow unit coupled to the first breathing layer by the porous bridge for drawing air and/or moisture vapor through the first breathing layer and the second breathing layer.

US Pat. No. 10,477,970

GAS CYLINDER

SAMHONGSA CO., LTD., Seo...

1. A gas cylinder comprising:a base tube comprising a cavity;
a spindle inserted into the cavity and performing a reciprocating motion in a longitudinal direction of the base tube;
a cylinder mounted in the spindle and charged with gas;
a piston dividing the cylinder into an upper chamber and a lower chamber;
a valve portion sealing an upper portion of the cylinder and comprising a pipe holder having a cavity through which the gas is introduced;
a flow prevention portion inserted into the spindle and having an inner surface contacting a surface of the spindle; and
a spindle guide disposed between the base tube and the spindle and mounted to comprise at least a portion of the flow prevention portion;
wherein:
the spindle guide comprises a first mounting portion formed along an inner surface of the spindle guide in a circumferential direction, and a first stopper bump protruding from an inner side wall toward the spindle;
an inner circumferential surface of the flow prevention portion contacts the surface of the spindle, while an outer circumferential surface of the flow prevention portion is spaced apart from the inner side wall of the spindle guide; and
the flow prevention portion moves between a bottom surface of the first mounting portion and the first stopper bump when the spindle reciprocates in a longitudinal direction of the base tube.

US Pat. No. 10,477,966

SYSTEM FOR OPTIMIZING USE OF STORAGE SPACE

1. A removable shelf extender for creating usable space within a storage cabinet having a pull-out sliding drawer with sidewalls, the removable shelf extender comprising:a continuous upright wall member having an upright wall portion and a connection portion that can be quickly and easily attached to the sidewall of the pull-out sliding drawer, thus providing lateral support to assist in for containing items within a space above an upper edge of the sidewalls of the pull-out sliding drawer;
wherein the upright wall portion provides a rigid upright containment surface extending upwardly and beyond the existing edge of the sidewall of the pull-out sliding drawer, the continuous upright wall member also extending along a length of the sidewall of the pull-out drawer thus providing the ability to contain product positioned within the space above the surface of the pull-out sliding drawer; and
an integral connection structure comprising a lateral extension protruding from an intermediate location on the upright wall member so that the upright wall portion of the continuous upright wall member extends above an upper surface of the lateral extension and the connection portion extends below the lateral extension, the lateral extension having a bridge portion extending substantially perpendicular to the continuous upright wall member and configured to rest upon an upper edge of the pull out drawer, and a holding portion extending in a downward direction from an end of the bridge portion, with the continuous upright wall member the integral connection structure being a single piece;
wherein the connection structure is flexible, thus allowing a bottom edge of the holding portion to be movable with respect to a lower edge of the upright wall portion, that the connection structure further configured to produce a compression force when the bottom edge is moved away from the lower edge of the upright wall portion, wherein the compression force is able to hold the upright wall member in position when attached to the pull-out sliding drawer, and wherein the connection structure is sized such that, when connected to the pull-out sliding drawer, the connection structure will not interfere with or contact the cabinet when the pull-out sliding drawer is slid out of the cabinet; and
wherein the holding portion has a length sized so that the bottom edge of the holding portion of the connection structure is not aligned with a bottom edge of the upright wall, thus making movement of the connecting structure more convenient, and such that the lateral extension will be located adjacent an upper edge of the sidewall.

US Pat. No. 10,477,964

LOCKER SEAT ASSEMBLY

1. A locker, comprising:a pair of upstanding side walls;
a seat assembly disposed between the side walls, the seat assembly comprising:
a generally horizontal seat bench; and
a multi-piece seatback comprising:
a lower seatback having an upper edge and being connected to and movable about a hinge between an open position and a closed position; and
an upper seatback having a lower edge and being connected to and movable about a hinge between an open position and a closed position;
wherein the lower edge of the upper seatback and the upper edge of the lower seatback are adjacent to each other when the upper seatback and the lower seatback are in the closed positions; and
wherein the lower seatback is configured to pivot downward toward the seat bench and the upper seatback is configured to move upward away from the seat bench as the multi-piece seatback transitions from the closed position to the open position.

US Pat. No. 10,477,956

COSMETIC SYSTEMS

HCT Group Holdings Limite...

1. A cosmetic system comprising:a handle having an applicator fixed to and extending away from a first end of the handle, and a cavity defined by a surface arranged in a second end of the handle opposite the first end of the handle, an opening of the cavity being disposed in the surface arranged in the second end of the handle and the cavity extending towards the first end of the handle, the first end of the handle having a smaller diameter than the second end of the handle;
a tweezer comprising a pinching tip having cooperating edges for grooming a portion of the body, the tweezer removably disposed in the cavity; and
a cap fixed to a fulcrum of the tweezer,
wherein when the tweezer is removably disposed in the cavity, the pinching tip is held in a closed position by the surface of the cavity to keep the cooperating edges of the pinching tip undamaged, the pinching tip and the applicator form a substantially straight line such that the applicator extends substantially opposite the fulcrum of the tweezer, and
wherein the second end of the handle has a substantially cylindrical exterior profile that provides a first gripping surface and a protruding portion extending away from the first gripping surface such that a radial width of the protruding portion is smaller than a diameter of the cylindrical exterior profile of the first gripping surface, and the cap has a recess and a substantially cylindrical exterior profile that provides a second gripping surface, such that when the cap is removably coupled with the second end of the handle by inserting the protruding portion into the recess, the first and second gripping surfaces form a single gripping surface having a continuously smooth exterior profile.

US Pat. No. 10,477,953

TOOTH CLEANING DEVICES AND PROCESSES FOR USING SAME

1. A process for using a tooth cleaning device, comprising:(a) providing the tooth cleaning device, wherein the device comprises a substantially planar base having opposing first and second sides;
a grip member extending proximally from the first side;
a plurality of first bristles attached to and distally extending from the second side;
optionally a plurality of second bristles attached to and distally extending from the second side; and
an oral care composition disposed within a housing or on the first bristles;
(b) gripping the grip member;
(c) dispensing the oral care composition such that the oral care composition is released onto the first bristles; and
(d) activating the oral care composition with the user's saliva and brushing the user's teeth with the first bristles.

US Pat. No. 10,477,946

MIRROR FOR APPLYING EYE COSMETICS

MYJF Enterprises, LLC, D...

1. A cosmetic mirror comprising:a base mirror at a surface of a base panel having two long sides and two short sides; and
a three-point reflection path between a first side mirror and a second side mirror at surfaces of a first side panel and a second side panel respectively, the first side panel and the second side panel affixed to opposing parallel edges of the two long sides of the base panel and the first side mirror and the second side mirror each positioned at an obtuse angle relative to the base mirror,
wherein the first side mirror and the second side mirror have a greater than 1× magnification selected according to a width of the base panel and a radius of curvature oriented to provide a distance from the first side mirror and the second side mirror shorter than the focal length.

US Pat. No. 10,477,938

MAKEUP DEVICE COMPRISING A PLURALITY OF COSMETIC DYES

1. A cosmetic assembly comprising, in the same packaging, a makeup device comprising a substrate defining a printing surface having at least three regions printed with at least one layer of coloring ink, each region differing from one another at least by the color they produce after application to the keratin materials, for application to human keratin materials, said at least one coloring inkhaving been deposited by printing on the printing surface by at least one digital printer,
not being covered with an adhesive, and
producing, after application to the keratin materials, at least one visible optical effect among color and/or brightness, andan applicator for the application of all or some of the coloring inks of the device to human keratin materials.

US Pat. No. 10,477,935

NAIL LAMP WITH COLOR-CHANGING EXTERIOR LIGHTING AND RECHARGEABLE BATTERY

LeChat, Hercules, CA (US...

1. A nail lamp comprising:an upper housing, wherein the upper housing comprises at least a portion having a translucent material;
a lower housing, coupled to the upper housing, wherein an enclosed space is between the upper and lower housings;
a display panel, wherein the display is capable of displaying at least two digits;
a first printed circuit board, positioned in the enclosed space between the upper and lower housings, wherein the first printed circuit board comprises electronic circuitry comprising a control circuit that is coupled to one or more buttons, accessible from an exterior of the nail lamp, and the display, and
by way of the one or more buttons, a user can select a curing time, which will be displayed on the display panel;
a second printed circuit board, coupled to the first printed circuit board and positioned in the enclosed space between the upper and lower housings, wherein the second printed circuit board comprises a plurality of interior-illuminating light emitting diodes that are coupled to the control circuit of the first printed circuit board,
light emitted by the interior-illuminating light emitting diodes is directed through apertures into a treatment chamber of the nail lamp, and
when on, the interior-illuminating light emitting diodes emit ultraviolet light;
a plurality of exterior-illuminating light emitting diodes, coupled to the control circuit of the first printed circuit board, wherein light emitted by the exterior-illuminating light emitting diodes strikes a surface of the translucent material, visible from the exterior of the nail lamp,
when on, the exterior-illuminating light emitting diodes emit non-ultraviolet light, the interior-illuminating light emitting diodes emit light in a first direction, the exterior-illuminating light emitting diodes emit light in a second direction, and the first direction is toward the treatment chamber and the second direction is away from the treatment chamber, and
while the exterior-illuminating light emitting diodes are on, a color of the light emitted by the exterior-illuminating light emitting diodes changes to be different colors comprising at least red, green, and blue shades.

US Pat. No. 10,477,931

SUNSHADE AND METHOD OF PREPARING A CANOPY

1. A sunshade comprising:a support frame; and
a canopy connected to said support frame and including a light-transmissible fabric sheet of undyed yarns that has opposite inner and outer surfaces, an ink layer directly formed on one of said inner and outer surfaces of said light-transmissible fabric sheet using dye-sublimation printing techniques, and an opaque enamel coating coated on the other of said inner and outer surfaces of said light-transmissible fabric sheet;
wherein said undyed yarns are woven and cross one another to form fabric pores thereamong, said opaque enamel coating filling said fabric pores; and
wherein said ink layer includes a pigment and is free of an adhesive resin.

US Pat. No. 10,477,925

METHOD OF PREPARING SHOE COMPONENTS

Chaei Hsin Enterprise Co....

1. A method of preparing shoe components comprising:providing a first shoe component and a second shoe component;
forming an adhesive member on one of the first and second shoe components;
stacking the first and second shoe components such that the adhesive member is disposed therebetween;
heating to melt the adhesive member so as to adhere the first and second shoe components to each other; and
suctioning air to adhere the first and second shoe components closely to each other.

US Pat. No. 10,477,922

GUIDES AND COMPONENTS FOR CLOSURE SYSTEMS AND METHODS THEREFOR

Boa Technology Inc., Den...

1. An elongate tension member guide that is coupleable with footwear and that is configured to direct or route a tension member about a path of the footwear, the tension member guide comprising:a main body having a longitudinal length and a lateral width, the main body being folded along the longitudinal length, the main body including:
a first edge that is coupleable with the footwear under an upper of the footwear so that the main body is positioned along an eyestay of the footwear;
a second edge that is positioned on an opposite side of the main body from the first edge; and
a plurality of slits or incisions in the main body through the second edge, the plurality of slits or incisions defining a plurality of loops or channels within which the tension member is insertable;
wherein each loop or channel is defined between a pair of slits or incisions;
wherein each loop or channel has a base portion that connects the loop or channel with the main body and a middle portion that is aligned with the second edge; and
wherein the middle portion of each loop or channel is wider than the base portion such that the middle portion protrudes or extends longitudinally outward from the base portion.

US Pat. No. 10,477,916

SOLE STRUCTURE FOR AN ARTICLE OF FOOTWEAR WITH FIRST AND SECOND MIDSOLE BODIES

NIKE, Inc., Beaverton, O...

1. A sole structure for an article of footwear, comprising:a first midsole body defining a ground-facing surface and a foot-facing surface opposite the ground-facing surface, wherein the first midsole body includes a first midsole material, and the first midsole material has a first hardness; and
a second midsole body extending through the first midsole body such that the second midsole body extends beyond the ground-facing surface of the first midsole body, wherein the second midsole body includes a second midsole material, the second midsole material has a second hardness, and the first hardness is greater than the second hardness;
wherein the second midsole body includes a midsole heel portion, a midsole forefoot portion, and a midsole midfoot portion between the midsole heel portion and the midsole forefoot portion;
wherein the midsole heel portion has a camber; and
wherein the second midsole body is tapered along the midsole midfoot portion and the midsole forefoot portion such that a width of the second midsole body decreases from the midsole midfoot portion toward the midsole forefoot portion.

US Pat. No. 10,477,915

DEVICE FOR HIGH-HEELED SHOES AND METHOD OF CONSTRUCTING A HIGH-HEELED SHOE

HBN SHOE, LLC, Salem, NH...

1. A device for insertion into a heeled shoe, the device comprising:a rear region having a foot supporting surface configured to underlie a wearer's calcaneal tuberosities;
a forward region having a foot supporting surface configured to underlie at least a portion of the shafts of the wearer's metatarsals;
a lateral side; and
a distal side;
wherein the rear region foot supporting surface includes first and second elongated ellipsoid-shaped depressed region, the first elongated ellipsoid-shaped depressed region being 2-5 times larger in area and deeper than the second elongated ellipsoid-shaped region to underlie respectively the lateral and medial tuberositites of the wearer's calcaneus;
wherein the first elongated ellipsoid-shaped depressed region has an elongate axis running in a rear-to-forward direction of the device and skewed in a direction towards the medial side of the device;
wherein the second elongated ellipsoid-shaped depressed region has an elongate axis running in a rear-to-forward direction of the device and skewed in a direction towards the lateral side of the device;
wherein the second elongated ellipsoid-shaped region is shorter in length than the first elongated ellipsoid-shaped region; and
wherein an upper surface of said rear region has a raised portion configured to underlie an area of the wearer's calcaneus forward of the wearer's lateral and medial tuberosities; and an upper surface of the forward region is configured to underlie at least a portion of the shafts of the wearer's metatarsals, the upper surface of said forward region having a generally rounded or ellipsoid shape raised portion which rises to an apex configured to underlie the shafts of the wearer's second and third metatarsals.

US Pat. No. 10,477,912

DYNAMIC LACING SYSTEM

NIKE, Inc., Beaverton, O...

1. A cable lock mechanism comprising:a housing defining a cavity;
a first cable having a first portion and a second portion;
a second cable having a first portion and a second portion;
a unitary spool disposed within the cavity and including a first annular groove receiving the first cable and a second annular groove receiving the second cable, the spool rotatable in a first direction relative to the housing to unwind the first cable from the housing and wind the second cable within the second annular groove and rotatable in a second direction relative to the housing to unwind the second cable from the housing and wind the first cable within the first annular groove; and
a first lock pawl supported by the housing and operable between a locked state restricting rotation of the spool relative to the housing in the second direction and an unlocked state permitting rotation of the spool relative to the housing in the second direction.

US Pat. No. 10,477,909

HELMET FOR IMPACT PROTECTION

Bauer Hockey, LLC, Exete...

1. A helmet for protecting a head of a wearer, the helmet comprising:an outer shell; and
inner padding connected to the outer shell, the inner padding configured to be disposed between the outer shell and the wearer's head, the inner padding comprising a plurality of pads separate from one another, each pad comprising a plurality of padding layers that overlap one another and are arranged such that adjacent ones of the padding layers of the pad are movable relative to one another in response to a rotational impact on the outer shell, wherein:
the pad comprises a low-friction interface between the adjacent ones of the padding layers of the pad to facilitate movement of the adjacent ones of the padding layers of the pad relative to one another;
the low-friction interface of the pad is between a first one of the padding layers of the pad and a second one of the padding layers of the pad; and
the low-friction interface of the pad is configured such that a coefficient of friction between the first one of the padding layers of the pad and the second one of the padding layers of the pad is lower than a coefficient of friction between a shock-absorbing material of the first one of the padding layers of the pad and a shock-absorbing material of the second one of the padding layers of the pad.

US Pat. No. 10,477,907

SKIN CARE MASK GLOVE AND MASK SOCK

VOESH CORPORATION, Plain...

1. A skin care mask sock, comprising:a sock portion having:
a first opening section having a first opening configured for receiving a foot and a first tightening strap for tightening said first opening section after the foot is inserted;
a foot section; and
a toe section having a first perforated line and a first removable toe tip portion, said first perforated line configured to extend across a user's toes such that when the first removable toe tip portion is removed along the first perforated line, all of the user's toes are exposed,
wherein said sock portion includes a first outer layer, a first inner layer and a layer of a first skin care product; and
a leg extension portion having:
a second opening section having a second opening configured for receiving the foot and a second tightening strap for tightening said second opening section after the foot is inserted;
a leg section; and
an ankle section coupled to said first opening section and having a third opening and a third tightening strap for tightening said ankle section after the foot is inserted,
wherein said first opening section is coupled to said ankle section via a middle section having a second perforated line; and
wherein said leg extension portion includes a second outer layer, a second inner layer and a layer of a second skin care product.

US Pat. No. 10,477,898

ELECTRONIC CIGARETTE

FONTEM HOLDINGS 1 B.V., ...

1. A vaporizing device, comprising:a housing;
liquid stored in the housing;
at least one air inlet for allowing air to flow into the housing;
a hollow electric heater coil around a first axis parallel to a longitudinal axis of the device, and the hollow electric heater coil surrounded by the liquid;
a channel extending through the hollow electric heater coil;
with the channel and an inhalation port forming an airflow path within the housing, and with the channel providing a continuous open passageway through the hollow electric heater coil to the inhalation port, with inhalation on the device causing air to flow through the hollow electric heater coil; and
an annular liquid permeating component around the first axis and sleeved on the hollow electric heater coil, with the hollow electric heater coil contacting an inner cylindrical surface of the liquid permeating component along substantially an entire length of the hollow electric heater coil, and with the liquid stored in the housing permeating through the liquid permeating component to the hollow electric heater coil for vaporization.

US Pat. No. 10,477,896

PHOTODETECTOR FOR MEASURING AEROSOL PRECURSOR COMPOSITION IN AN AEROSOL DELIVERY DEVICE

RAI Strategic Holdings, I...

1. An aerosol delivery device comprising:at least one housing enclosing a reservoir configured to retain an aerosol precursor composition;
a heating element controllable to activate and vaporize components of the aerosol precursor composition;
a light source configured to emit light into the reservoir;
a photodetector configured to detect a reflection of the light, wherein the reflection of the light indicates an amount of aerosol precursor composition retained in the reservoir;
a flow sensor configured to detect a flow of air through at least a portion of the at least one housing; and
a control component coupled to the photodetector and configured to control operation of at least one functional element of the aerosol delivery device based on the reflection so detected, and thereby the amount of aerosol precursor composition,
wherein the control component is configured to operate in an active mode to control the heating element to activate and vaporize components of the aerosol precursor composition only when both the flow of air is detected by the flow sensor, and the reflection of the light indicates at least a threshold amount of the aerosol precursor composition.

US Pat. No. 10,477,884

APPARATUS FOR EGG SEPARATION

1. An egg separating apparatus comprising:a) a substantially square support frame member defining an inner opening;
b) a plurality of rod members that are attachably connected to said support frame member within said opening, wherein said rod members comprise a substantially semi-circular configuration with a substantially curved and rounded top surface in order to provide a substantially smooth exterior and thus prevent an egg yolk from breaking upon contact with said top surface; and
c) a plurality of vents that are formed between said rod members, wherein said vents comprise a width distance that is relatively wide enough to allow at least one egg white to pass through said vents, but that is relatively narrow enough to prevent at least one egg yolk from passing through said vents.

US Pat. No. 10,477,883

GAS INJECTION ASSEMBLIES FOR BATCH BEVERAGES HAVING SPARGERS

Cornelius, Inc., Saint P...

1. A gas injection assembly for injecting a gas into a liquid to form a solution, the gas injection assembly comprising:a vessel configured to receive the liquid, wherein the vessel has an open end;
a top cap on the open end of the vessel and having an intake passageway;
an intake member defining a central bore, the intake member coupled to the top cap and configured to receive the liquid from the vessel and dispense the liquid to the intake passageway;
a flow channel having an upstream inlet configured to receive the liquid from the intake passageway and a downstream outlet configured to dispense the solution; and
a sparger having a porous surface positioned in the flow channel, wherein the sparger is configured to inject the gas through the porous surface into the liquid to thereby form the solution.

US Pat. No. 10,477,879

MACHINE FOR MAKING LIQUID OR SEMI-LIQUID FOOD PRODUCTS AND METHOD OF OPERATING THE MACHINE

1. A machine for making liquid or semi-liquid food products, comprising:a processing chamber for processing a basic mixture and including a stirrer and a thermal treatment system for the basic mixture, operating in conjunction with one another to convert the basic mixture into a liquid or semi-liquid product;
a dispensing device including a dispensing nozzle connected to the processing chamber to deliver the liquid or semi-liquid product,
a support having a housing seat for housing a receiving container;
a movement mechanism suitable for vertically moving the support between a vertical position away from the dispensing nozzle and a vertical position close to the dispensing nozzle;
a rotation mechanism suitable for rotating the housing seat about a vertical axis;
wherein the movement mechanism comprises a slide, which the support is mechanically connected to, and at least one guide for vertically guiding the slide;
wherein the movement mechanism comprises: a cantilevered element which is cantilevered from the slide, and a first shaft supported by the cantilevered element and connected to the support;
a first motor connected to the first shaft and supported by the cantilevered element;
wherein the rotation mechanism comprises a second shaft and a second motor;
wherein the second shaft is rotatable independently of the first shaft.

US Pat. No. 10,477,875

FLAVORING DEVICE

Electrolux Professional S...

1. A flavoring device adapted to be associated with a cooking chamber of a cooking oven adapted to cook food stored therein, the flavoring device comprising:a flavoring casing having a first air inlet opening arranged for allowing air to enter said flavoring casing, a flavoring air outlet opening arranged for allowing air contained within said flavoring casing to pass to said cooking chamber, and a flavoring air path traversing said flavoring casing and fluidly connecting said first air inlet opening to said flavoring air outlet opening; andan actuating arrangement comprising a heating element and a temperature sensor, said actuating arrangement being coupled to said flavoring casing at least while in operation so that said heating element is arranged in said flavoring air path for heating the air flowing through said flavoring air path, said flavoring casing, further comprising a removable flavoring substance rack arranged at least partially in said flavoring air path downstream of said heating element and adapted to contain at least one flavoring substance,wherein the heating element is spaced apart from the flavoring substance rack in operation such that heat is transferred from said heating element to said flavoring substance rack mainly by air flowing inside the flavoring casing from the first air inlet opening to the flavoring air outlet opening through said flavoring air path.

US Pat. No. 10,477,867

OVEN APPLIANCE WITH AIR CURTAIN

Haier US Appliance Soluti...

1. An oven appliance defining a vertical direction, a lateral direction, and a transverse direction, the vertical, lateral, and transverse directions being mutually perpendicular, the oven appliance comprising:a housing defining a cooking chamber, the cooking chamber extending between a top portion and a bottom portion along the vertical direction, the housing also defining an opening for accessing the cooking chamber of the housing, the cooking chamber extending from the opening to a wall along the transverse direction;
an upper heating element array positioned within the housing at the top portion of the cooking chamber;
a baking stone positioned within the housing at the bottom portion of the cooking chamber;
a lower heating element array positioned within the housing below the baking stone adjacent the bottom portion of the cooking chamber;
a duct at least partially defined by the wall and extending between an inlet defined in the wall below the baking stone and an outlet defined in the wall above the upper heating element array;
a hollow casing mounted to the housing at the opening of the housing, the hollow casing defining a lower portion and an upper portion spaced apart from the lower portion along the vertical direction, the hollow casing comprising an ambient air intake in the lower portion proximate to and contiguous with interior room ambient atmosphere about the housing, a smoke inlet proximate to and contiguous with the cooking chamber, a venting exit in the upper portion proximate to and contiguous with the interior room ambient atmosphere about the housing, and an air curtain outlet proximate to the opening of the housing, wherein the oven appliance defines a first air flow path from the lower portion of the hollow casing to the upper portion of the hollow casing via the duct and a second air flow path from the lower portion of the hollow casing to the upper portion of the hollow casing via a side portion of the hollow casing; and
an air handler located within the hollow casing and operable to cause gases to flow into the ambient air intake and the smoke inlet, such that the gases from each of the ambient air intake and the smoke inlet intermix within the hollow casing and the mixed gases flow to the venting exit and to the air curtain outlet;
wherein the opening of the housing defines a width along the lateral direction, the air curtain outlet also defining a width along the lateral direction, the width of the air curtain outlet being substantially equal to the width of the opening.

US Pat. No. 10,477,864

MICROBIOCIDAL QUINOLINE (THIO)CARBOXAMIDE DERIVATIVES

Syngenta Participations A...

1. A compound of formula (I):
wherein
X is O or S;
R1 is hydrogen, halogen, methyl, methoxy or cyano;
R2 and R3 are each independently hydrogen, halogen or methyl;
R4 is hydrogen, cyano, C1-C4 alkyl, or C3-C4 cycloalkyl, wherein the alkyl and cycloalkyl, may be optionally substituted with 1 to 3 substituents independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy and C1-C3 alkylthio;
R5 and R6 are each independently selected from hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy and C1-C4 alkylthio; or
R5 and R6 together with the carbon atom to which they are attached represent C?O, C?NORc, C3-C5 cycloalkyl or C2-C5 alkenyl, wherein the cycloalkyl and alkenyl may be optionally substituted with 1 to 3 substituents independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy and C1-C3 alkylthio;
R7 is hydrogen, C1-C5 alkyl, C3-C5 cycloalkyl, C2-C5 alkenyl, C3-C5 cycloalkenyl, or C2-C5 alkynyl, wherein the alkyl, cycloalkyl, alkenyl, alkynyl, cycloalkenyl may be optionally substituted with 1 to 4 substituents independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, hydroxyl and C1-C3 alkylthio;
R8 and R9 are each independently selected from hydrogen, halogen, C1-C4 alkyl and C1-C4 alkoxy; or
R8 and R9 together with the carbon atom to which they are attached represent C3-C5 cycloalkyl, wherein the cycloalkyl may be optionally substituted with 1 to 3 substituents independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy and C1-C3 alkylthio;
each R10 independently represents halogen, nitro, cyano, formyl, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C6 cycloalkyl, C1-C5 alkoxy, C3-C5 alkenyloxy, C3-C5 alkynyloxy, C1-C5 alkylthio, —C(?NORc)C1-C5 alkyl, or C1-C5 alkylcarbonyl, wherein the alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy and alkylthio may be optionally substituted with 1 to 5 substituents independently selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, cyano and C1-C3 alkylthio; n is 0, 1, 2, 3, 4 or 5;
each Rc is independently selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C3-C4 alkynyl, C3-C4 cycloalkyl(C1-C2)alkyl and C3-C4 cycloalkyl, wherein the alkyl, cycloalkyl, alkenyl and alkynyl groups may be optionally substituted with 1 to 3 substituents independently selected from halogen and cyano;
R11 is hydrogen, halogen, methyl, methoxy or cyano;
R12 and R13 are each independently selected from hydrogen, halogen, methyl, methoxy or hydroxyl;
and salts and/or N-oxides thereof;
provided that the compound is not one of the following compounds:
, ora compound wherein R1 is hydrogen, R2 is hydrogen, R3 is methyl, R4 is hydrogen, R5 is hydrogen, R6 is hydrogen, R7 is hydrogen, R8 is hydrogen, R9 is hydrogen, n is 1, R10 is 2-methyl, R11 is fluoro, R12 is hydrogen, R13 is hydrogen, and X is O.

US Pat. No. 10,477,863

USE OF HERBICIDAL COMPOSITIONS FOR CONTROLLING UNWANTED VEGETATION

BASF SE, Ludwigshafen am...

1. A method for controlling unwanted vegetation in crop plants, which comprises treating plants, their seeds and/or their habitat with a herbicidal composition comprising as componentA) 4-(2,4-dichlorophenoxy)butanoic acid of formula (I) or salts or esters thereof

and as component
B) 3,6-dichloro-2-methoxybenzoic acid of formula (II) or salts or esters thereof,

wherein the weight ratio of components A) to B) based on acid equivalents is from 1:12 to 1:50.

US Pat. No. 10,477,860

HIGH OSMOLARITY ANTIMICROBIAL COMPOSITION CONTAINING ONE OR MORE ORGANIC SOLVENTS

Next Science IP Holdings ...

1. An antimicrobial composition adapted for dermal application, said composition comprising (a) a carrier base and (b) a liquid composition exhibiting an effective solute concentration of at least about 0.75 Osm/L and a pH of at least 3, wherein said liquid composition consists of(1) a solvent component that exhibits a ?p value of no more than 14.4 MPa1/2 and consists of water, one or more C1-C16 acyclic alcohols and, optionally, glycerol; and
(2) a solute component that comprises cationic surfactant and dissociation products of at least two organic acids.

US Pat. No. 10,477,856

MECHANISM CHASSIS FOR MECHANICAL WILD BIRD AND ANIMAL REPELLENT DEVICE

1. A mechanism chassis for mechanical wild bird and animal repellent devices, comprising:a body, wherein the body comprises a bush formed to a top side of the body, a bush bearing connected to the bush, a trigger pin formed to a front side of the body, an automatic bearing penetrating the front side and a rear side of the body, a gas cutting pin formed on the front side of the body, a plurality of hammer lever bearings formed on an inner surface of the top side of the body, a blower bowl bearing formed on a bottom side of the body, a door drawer bearing formed on the blower bowl bearing, a body connection part formed on the rear side of the body, a plurality of magneto and plug fastening holes formed on the top side and a left side of the body, a plurality of cap tightening bolt holes formed on the front side of the body, a plurality of hose holes formed on a right side of the body for gas entrance/exit, a plug tightening strip bearing formed on the left side of the body and a raincoat bearing formed on the rear side of the body,
a cap connected to the body,
a chassis connection part wherein the chassis connection part is mounted on the body connection part, and
a raincoat, wherein the raincoat is attached to the raincoat bearing,
wherein the body, the cap, the chassis connection part and the raincoat are made from a composite plastic material; and wherein the body is produced in one-piece.

US Pat. No. 10,477,855

RODENT BAIT STATION HAVING A COUNTING MECHANISM

1. A rodent bait station having a counting mechanism, comprising:a housing, wherein said housing is configured to be fastened to an anchoring surface with a fastener, said housing having at least one opening, said housing having a bait chamber, said bait chamber having at least one bait chamber opening;
a sensor, wherein said sensor is in communication with said at least one bait chamber opening, whereby, said sensor is configured to detect the presence of a rodent passing through said at least one bait chamber opening of said housing;
a counting mechanism, said counting mechanism is in communication with said sensor, said counting mechanism is configured to be activated when said sensor detects the presence of a rodent passing through said at least one bait chamber opening of said housing, said counting mechanism is in communication with a database, said database is configured to retain data associated with the number of times said counting mechanism is activated, said database is in electrical communication with an application program, said application program is in electrical communication with an electronic device, whereby, said application program is configured to be monitored by a user through said electronic device;
a lid, said lid is hingedly connected to said housing;
at least one bait rod, said at least one bait rod having a first end located opposite a second end, said first end of said at least one bait rod is connected to an inner surface of said housing, said second end of said at least one bait rod is configured to receive a bait; and,
a resilient member, said resilient member is in communication with said first end of said at least one bait rod, whereby, said at least one bait rod is positioned in a substantially horizontal orientation when said lid of said housing is closed and said at least one bait rod is positioned in a substantially vertical orientation when said lid of said housing is opened.

US Pat. No. 10,477,853

HEATING CHAMBER SYSTEM AND METHOD FOR INSECT EXTERMINATION

ZAPPBUG, INC., Seattle, ...

1. A heating chamber system comprising:an enclosed heating chamber;
a bottom portion defining a lower portion of the enclosed heating chamber and includes a floor skirt and a floor;
a top portion defining an upper portion of the enclosed heating chamber and including a plurality of sidewalls and a roof;
a collapsible architecture configured to support the top portion; and
a heating system comprising:
a heater configured to generate and expel heated air, the heater including a set of electrically isolated heating elements;
a control system operably coupled to the heater and configured to control the generation of the heated air by the heater, the control system including:
a touch-screen interface; and
more than two electrically isolated power cord assemblies configured to simultaneously provide power of a same voltage to a respective electrically isolated heating element of the set of electrically isolated heating elements, the power of the same voltage originating from separate outlet receptacles associated with one or more circuits having the same voltage that the power cord assemblies are respectively plugged into simultaneously, each power cord assembly of the power cord assemblies having a cord and a plug;
wherein the control system is operably connected to a remote user device via a wireless network such that the control system can send data regarding a state of the heating chamber to the user device and such that the user device can send control instructions to the control system such that the control system controls the state of the heating chamber based on the control instructions received from the user device;
wherein the control system is configured to generate a treatment cycle based on the instructions received from the remote user device and the touch-screen interface, where the treatment cycle includes:
a first portion that substantially utilizes a maximum power available from the one or more power circuits that the heating chamber system draws the power from, the first portion having a duration of about 3 hours; and
a second portion after the first portion having a lower power-consumption mode that utilizes 80% or less of the maximum power available from the one or more power circuits;
wherein the control system is further configured to generate the treatment cycle based at least in part on a received first indication of whether the power cord assemblies are coupled with two or three separate electrical power circuits of the one or more power circuits, the first indication receivable via at least one of the user device and the touch screen interface;
wherein the control system is further configured to generate the treatment cycle based at least in part on a received second indication of an amperage of the two or three separate electrical power circuits of the one or more power circuits, the second indication receivable via at least one of the user device and the touch-screen interface.

US Pat. No. 10,477,851

DUAL-BEARING REEL

Shimano Inc., Osaka (JP)...

1. A dual-bearing reel, comprisinga reel body having a boss portion;
a shaft member extending through the boss portion and rotatably supported in the reel body;
a roller clutch including an outer race non-rotatably mounted in the boss portion, an inner race connected to the shaft member so as to be integrally rotatable, and a rolling element disposed between the outer race and the inner race, the roller clutch preventing rotation of the shaft member in one direction, the outer race including a plurality of protruding portions; and
a prevention member mounted on an outer perimeter of the boss portion within lateral confines of the roller clutch to prevent radially outward expansion of the boss portion and the roller clutch.

US Pat. No. 10,477,850

BEARING HOUSING STRUCTURE AND DUAL-BEARING REEL

Shimano Inc., Osaka (JP)...

1. A bearing housing structure, comprising:a bearing rotatably supporting a spool shaft;
a lid part disposed at an end surface of the spool shaft and extending in a direction that intersects the spool shaft; and
a supporting part housing and supporting the bearing and holding the lid part at the end surface of the spool shaft,
the supporting part including a bearing hole and a lid hole, the bearing hole configured to have the bearing inserted thereinto and removed therefrom in a direction along the spool shaft, and the lid hole configured to have at least a portion of the lid part inserted thereinto and removed therefrom in the direction that intersects the spool shaft and a direction along which the lid part extends, and
the lid part is configured to close an opening of the bearing hole such that the lid part is held by the lid hole of the shaft supporting portion.

US Pat. No. 10,477,849

DUAL-BEARING REEL

Shimano Inc., Osaka (JP)...

1. A fishing reel, comprising:a reel body;
a handle rotatable relative to the reel body;
a spool rotatable relative to the reel body;
a spool shaft connected to the spool so as to be integrally rotatable, and having a first abutting portion;
a clutch mechanism configured to transmit and prevent a rotational force from the handle to the spool;
a pinion gear configured such that the spool shaft extends through an inner circumferential portion thereof, configured to move in an axial direction of the spool shaft, between a coupled position in which the pinion gear is connected to the spool shaft so as to be integrally rotatable, and a decoupled position in which the connection with the spool shaft is disconnected, and having a second abutting portion configured to abut the first abutting portion in the axial direction in the inner circumferential portion; and
an elastic member configured to contact a distal endmost surface of the pinion gear and bias the first abutting portion of the spool shaft and the second abutting portion of the pinion gear in directions away from each other, when the pinion gear is in the coupled position.

US Pat. No. 10,477,847

ROLLER CLUTCH FOR FISHING REEL

Shimano Inc., Osaka (JP)...

1. A roller clutch for a fishing reel, comprising:an outer ring including a radially inner side;
an inner ring disposed on the radially inner side of the outer ring;
a roller disposed between the inner ring and the outer ring, and configured to move between a transmitting position to transmit power between the outer ring and the inner ring and a non-transmitting position to prevent transmission of the power;
a torsion spring configured to bias the roller toward the transmitting position; and
a housing member having a housing hole housing the torsion spring, the housing hole being defined by an inner wall surface, the inner wall surface supporting the torsion spring on an outer surface thereof.

US Pat. No. 10,477,846

SPOOL FOR FISHING REEL

Shimano Inc., Osaka (JP)...

1. A spool for a fishing reel attached to a reel body of the fishing reel, which is capable of casting a fishing line forward, and moving back and forth along a spool axis together with a rotation of a handle that is attached to the reel body, comprising:a spool body having a bobbin trunk around which the fishing line is capable of being wound, an annular flange extending from a front end portion of the bobbin trunk in a radially outward direction that intersects the spool axis, and a tubular connecting portion extending forward from the annular flange;
a spool ring surrounding an outer peripheral edge of the flange from the radially outward direction, and attached to the flange so as to be separable from a front direction;
a fixing ring attached to the spool body via the tubular connecting portion so as to be separable from the front direction and configured to fix the spool ring against the flange from the front direction; and
a first regulating part configured to regulate relative movement of the fixing ring with respect to the spool body detachably attached to the tubular connecting portion by being inserted into the tubular connecting portion in a direction transverse to the spool axis.

US Pat. No. 10,477,845

SNAG-RESISTANT FISHING LURE

BLADEMAN, LLC, Rock Hill...

1. A fishing lure comprising:a jig having a weighted body with a jig longitudinal axis and a hook extending from the body along the jig longitudinal axis, the jig longitudinal axis being located in a first horizontal plane;
a wire loop having a fixed stem extending from a forward end of the body in a second horizontal plane above the first horizontal plane, an intermediate circular portion connected to the fixed stem, and a distal end; and
a blade comprising a first edge proximate to the body, a blade tip distal to the first edge, a transverse axis bisecting the blade between the first edge and the blade tip, a first attachment hole through the blade proximate to the first edge, a second attachment hole axially aligned with and spaced proximate to the first attachment hole, and a line attachment;
wherein the first attachment hole and the second attachment hole are disposed between the first edge and the transverse axis, and wherein the second attachment hole is disposed between the first attachment hole and the transverse axis;
wherein the first attachment hole has a first diameter, and the second attachment hole has a second diameter, the first diameter being smaller than the second diameter;
wherein the intermediate circular portion extends directly through both the first attachment hole and the second attachment hole; and
wherein the fixed stem is sufficiently long that, during lure retrieval as the blade moves in a side-to-side motion, the side-to-side motion is limited by the intermediate circular portion contacting a first hole edge defining the first attachment hole or a second hole edge defining the second attachment hole rather than by contacting the weighted body.

US Pat. No. 10,477,843

FISHING HOOK WITH TIE RAIL

Clam Corporation, Rogers...

1. A fishing hook assembly comprising:a jig head having a length and having a distal end;
a hook element being of unitary construction and defined by a shaft, the shaft including a head portion and a tail portion, the tail portion including a generally straight shank portion and a curved portion extending proximally from the generally straight shank portion of the tail portion of the shaft and having a free end that includes a barb, the head portion having a generally straight portion extending distally in an opposite direction away from the tail portion, the head portion further comprising a tie rail portion extending beyond the distal end of the jig head and externally to and spaced from a side of the jig head;
wherein a line-pass-through area is defined by an interior area extending between the tie rail portion and an outer surface of the side of the jig head opposite to and facing the tie rail portion;
wherein the tie rail portion includes a first end where the tie rail portion extends distally from both the distal end of the jig head and the generally straight portion of the head portion in the opposite direction away from the tail portion and a second end where the tie rail portion extends outwardly from the outer surface of the side of the jig head at a location that is spaced from the first end of the tie rail portion and from the distal end of the jig head more than a distance between the tie rail portion and the outer surface of the side of the jig head;
wherein the head portion of the shaft is connected to at least a portion of the jig head; and wherein the line-pass-through area defines a first cross-sectional area which is substantially larger than a cross-sectional area of the shaft.

US Pat. No. 10,477,837

CAT ACTIVITY TOY

1. An interactive cat toy, comprising:a housing fabricated from a durable material, the housing have at least one opening for a passageway to a respective side of the housing;
an object of prey associated with each opening of the at least one opening, the object of prey dimensioned to be received within a corresponding passageway for moving relative to a respective opening;
a motor operatively coupled to the object of prey and communicating with a supply of an electrical current for moving the object of prey between a recessed position within the housing and an extended position outwardly of the housing through the respective opening;
a controller for receiving an operational schedule for operation of the motor, wherein the controller is communicatively coupled to a processor;
the processor configured to receive the operational schedule from the controller and to control delivery and cessation of electrical current to the motor according to the operational schedule, wherein the motor in operation is configured to move the object of prey relative to the opening.

US Pat. No. 10,477,835

FEEDING APPARATUS FOR ANIMALS

Crystal Spring Colony Far...

1. An apparatus for feeding animals comprising:a feed dispensing system;
a plurality of feed dispensing containers at each of which at least one animal can take feed material;
each of said plurality of feed dispensing containers comprising: a respective upstanding feed supply duct portion connected to the feed dispensing system so as to receive feed therefrom;
the respective feed supply duct portion being configured so that feed therein from the feed dispensing system falls by gravity to the respective feed dispensing container;
a rotary drive member mounted at the duct portion and including a plurality of paddle blades of a paddle wheel mounted for rotation about an axis of the wheel such that falling feed in the duct acts to drive the paddle blades to rotate the wheel about the axis;
a dispensing container containing a particulate additive material mounted on one side of the duct portion;
a feed wheel at the dispensing container driven by the paddle wheel which meters particulate additive material from the dispensing container to an outlet thereof which is arranged to discharge into the feed duct portion to mix with the feed therein.

US Pat. No. 10,477,830

FLEXIBLE NECKRAIL COUPLING

Michael Earls, Athenry (...

1. A coupling component for an animal cubicle, comprising:an engagement member;
a first closed pipe collar transverse to the engagement member for holding a neckrail in contact thereto;
a flexible member extending in opposite directions from the engagement member and connecting the engagement member to the pipe collar such that the flexible member encircles a space adjacent the pipe collar;
wherein deformation of the flexible member allows relative movement between the engagement member and the first closed pipe collar such that the first closed pipe collar holds the neckrail in contact thereto during the relative movement.

US Pat. No. 10,477,829

METHOD AND SYSTEM FOR PRESSING OUT WHEY FROM CURD

1. A method for pressing out whey from curd, said method comprising;receiving a closed casing holding a mould filled with curd,
pumping out air from said closed casing such that a pressure force onto said curd can be formed,
establishing a connection between a system controller and a casing controller provided in said casing,
uploading instructions from said system controller to said casing controller on how to change said pressure force during a pressing cycle by opening a valve on said casing,
de-establishing said connection between said system controller and said casing controller,
storing said closed casing and executing said instructions uploaded to said closed casing such that whey is pressed out from said curd and a cheese is formed from said curd,
wherein said pressure force onto said curd is formed by having a first space between a lid placed on top of said curd and a movable element and a second space between said movable element and said casing, the movable element comprising two resiliently spaced apart plates, and
wherein a pressure difference between said first space and said second space provides for said movable element to be pressed onto said lid such that in turn said pressure force is formed onto said curd.

US Pat. No. 10,477,827

VISION SYSTEM FOR TEAT DETECTION

Technologies Holdings Cor...

1. A vision system comprising:a robotic arm configured to attach a teat cup to a dairy livestock in a stall;
a laser configured to generate a plurality of profile signals, each profile signal comprising information associated with a relative distance between the laser and at least a portion of the dairy livestock;
one or more memory devices operable to store historical teat location information for a plurality of teats of the dairy livestock; and
a processor communicatively coupled to the laser and the one or more memory devices, the processor configured to:
determine that the teat cup is to be attached to a front teat of the dairy livestock;
determine, from the historical teat location information, an amount of separation between the front teat and a rear teat of the dairy livestock, the front teat having a front teat position;
determine that the amount of separation between the front teat and the rear teat is greater than or equal to a predetermined distance;
in response to determining that the amount of separation between the front teat and the rear teat is greater than or equal to the predetermined distance, calculate an updated front teat position based on the amount of separation between the front teat and the rear teat;
command the robotic arm to move to a first location that corresponds to the updated front teat position;
command the robotic arm to move up a predetermined amount after the robotic arm moves to the first location;
command the laser to perform a scan of the dairy livestock after the robotic arm moves up the predetermined amount;
access a first profile signal generated by the laser from the first scan;
determine that the front teat is found in the first profile signal; and
in response to determining that the front teat is found in the first profile signal, command the robotic arm to attach the teat cup to the front teat.

US Pat. No. 10,477,826

MILKING BOX WITH ROBOTIC ATTACHER

Technologies Holdings Cor...

1. A method, comprising:positioning a robotic attacher under a dairy livestock located in a milking stall, wherein the robotic attacher extends along a longitudinal axis and comprises a nozzle;
rotating the robotic attacher about the longitudinal axis such that the nozzle moves to a position generally on the top of the robotic attacher;
performing a spraying operation using the nozzle; and
retracting the robotic attacher from under the dairy livestock.

US Pat. No. 10,477,785

ULTRASONIC-BASED SYSTEM FOR DETECTION OF METALLIC SECURITY THREATS CONTAINERS ON CARGO

Northeastern University, ...

1. A method for imaging an object on a surface, the method comprising:exciting a surface with ultrasonic excitation from an ultrasonic transmitter having an ultrasonic transducer in contact with the surface;
moving (i) the surface relative to the ultrasonic transmitter and an ultrasonic receiver or (ii) the ultrasonic transmitter and the ultrasonic receiver relative to the surface; and
imaging, at a processor, a two-dimensional representation of the object acoustically coupled to the surface based on ultrasonic reflections received at the ultrasonic receiver in contact with the surface.

US Pat. No. 10,477,781

PLANT TRAY

Blackmore Company, Inc., ...

1. A horticulture tray having a plurality of growing cells each configured to accommodate a stabilized growth plug therein, each stabilized growth plug including a plant, soil, and a soil wrapper, each growing cell comprising:a first end defining an aperture configured to receive the stabilized growth plug;
a second end opposite to the first end, at the second end are a plurality of drain holes for allowing excess liquid to drain therethrough;
a sidewall extending from the first end to the second end, the sidewall tapers inward from the first end to the second end, the sidewall defines a plurality of arcuate chambers disposed radially about a central axis of the growing cell, the plurality of arcuate chambers are joined together to define the growing cell and each have an interior shape that is concave relative to the central axis; and
a support peak arranged along a longitudinal axis of the growing cell such that the support peak is at a center of the plurality of arcuate chambers, the support peak is proximate to, but spaced apart from, the second end, the support peak supports the stabilized growth plug spaced apart from the second end;
wherein:
at the second end, outer portions of the plurality of drain holes are defined by the plurality of arcuate chambers, and inner portions of the plurality of drain holes are defined by inner arcuate surfaces that extend upward and away from the second end to form the support peak;
the support peak is configured to protrude into a center of the stabilized growth plug and force soil of the stabilized growth plug outward and away from the support peak;
the sidewall is angled to force soil of the stabilized growth plug inward and away from the sidewall; and
the support peak and the sidewall force soil of the stabilized growth plug together between the support peak and the sidewall to compact the soil to form a soil bridge that extends between the support peak and the sidewall, and prevents soil from passing to the second end.

US Pat. No. 10,477,779

BOTANICAL AIR FILTRATION SYSTEM AND METHOD

Purdue Research Foundatio...

1. A botanical air filtration system comprising:an enclosure;
a wall within the enclosure;
two or more horizontal plant beds on which living plants are supported and grow within the enclosure, the plant beds being arranged in vertical tiers along the wall, each of the plant beds comprising a growth media and a tray that contains the growth media, each of the trays having a bottom surface that supports the growth media and holes in the bottom surface through which air moving through the plant bed is able to flow downwardly through the growth media and then exit the plant bed through the bottom surface of the tray;
an airflow pattern within the enclosure wherein air moving through the enclosure flows horizontally across each of the plant beds from a front of the tray thereof to a back of the tray thereof, over and through leaves of the plants of the plant beds, then downwardly through the growth media, then downwardly through the holes in the bottom surface of the tray, and then out of the enclosure, the holes in the bottom surface of each of the trays defining a hole pattern that promotes a uniform air flow across the tray;
an irrigation system for watering the plants; and
a lighting system for simulating sunlight.

US Pat. No. 10,477,775

BALER MASS FLOW SENSING ASSEMBLY AND METHOD

IOWA STATE UNIVERSITY RES...

1. A crop sensing system for a baler comprising:a compression system for forming a bale;
a feed system for picking up crop from a surface and conveying the crop to the compression system;
a sensor arrangement including at least one sensor being coupled to at least one of the compression system or the feed system, the at least one sensor configured to generate signals over a duration of time which correspond to a series of instantaneous crop loads on the at least one of the compression system or the feed system; and
a control unit configured to receive the signals from the sensor arrangement over the duration of time and calculate crop mass flow rate based on at least the signals and the duration of time recorded in conjunction with the signals,
wherein the baler includes a loading fork having a range of motion for passing crop from a pre-compression chamber into the compression system, wherein the at least one sensor is a first sensor coupled to the loading fork, wherein the signals are first signals from the first sensor, wherein the sensor arrangement includes a second sensor coupled to the pre-compression chamber and configured to generate a second signal, and wherein the control unit is configured to calculate the crop mass flow rate based on at least 1) the first signals from the first sensor corresponding to crop loads on the loading fork and the duration of time recorded in conjunction with the first signals and 2) the second signal from the second sensor corresponding to the crop load on the pre-compression chamber.

US Pat. No. 10,477,774

WINDROW FLUFFING ROLL ASSEMBLY FOR AN AGRICULTURAL MACHINE

1. A mower-conditioner assembly of a self-propelled windrower, comprising:a frame;
a cutting mechanism coupled to the frame and configured to cut crop;
a conditioner rotatably coupled to the frame at a location rearward of the cutting mechanism, the conditioner configured to crimp the crop;
a fluffer assembly rotatably coupled to the frame at a location rearward of the conditioner, the fluffer assembly including at least an elongated roll and a crop moving element;
a hood positioned partially around the fluffer assembly; and
a deflector pivotally coupled to the hood and positioned partially around the fluffer assembly;
wherein, an angle of the deflector relative to the hood is adjustable;
wherein, crop is projected from the conditioner to the fluffer assembly and directed to the ground through the hood and deflector;
further wherein, the fluffer assembly configured to fluff the crop.

US Pat. No. 10,477,772

GARDENING TOOL

Chervon (HK) Limited, Wa...

1. A gardening tool, comprising:a main body;
a plurality of wheels supporting the main body;
a cutting blade disposed in the main body;
a motor supported by the main body for driving the cutting blade;
an operation assembly for being operated by a user to activate the motor;
a handle rotatably connected to the main body and including two telescopic members slidably connected to each other; and
a control device for sending a control signal to allow the motor to be activated by the operation assembly when one of the telescopic members is caused to be moved to a predetermined position relative to another one of the telescopic members and to prevent the motor from being activated by the operation assembly when the one of the telescopic members is caused to be moved away from the predetermined position relative to the another one of the telescopic members.

US Pat. No. 10,477,769

DRIVE SYSTEM FOR PADDLE BELT CONVEYOR

AG GROWTH INTERNATIONAL I...

1. A drive system for a paddle belt conveyor, the drive system comprising:a drive shaft;
a drive roller rotationally driven by the drive shaft about a first axis, the drive roller exerting traction on a belt of the belt conveyor, wherein the belt comprises a plurality of paddles; and
a pinch roller mounted rotationally about a second axis parallel to the first axis, the pinch roller pinching the belt between the pinch roller and the drive roller to augment the traction of the drive roller on the belt, wherein one of the driver roller and the pinch roller is a bobbin roller to accommodate the paddles of the belt;
wherein the paddles have a height substantially equal to a difference between an outer radius of the bobbin roller and an inner radius of the bobbin roller.

US Pat. No. 10,477,766

VARIABLE BASECUTTER ASSEMBLY

1. A basecutter assembly for a sugarcane harvester, the basecutter assembly comprising:a first cutter and a second cutter, the first and second cutters adapted to sever sugarcane stalk;
a first feeder and a second feeder, the first and second feeders adapted to feed the severed sugarcane stalk, the first cutter and the first feeder arranged to rotate relative to one another about a first rotation axis, the second cutter and the second feeder arranged to rotate relative to one another about a second rotation axis;
a cutter drive coupled to the first cutter and the second cutter to rotate the first cutter and the second cutter respectively about the first rotation axis and the second rotation axis;
a feed drive coupled to the first feeder and the second feeder to rotate the first feeder and the second feeder respectively about the first rotation axis and the second rotation axis, the feed drive arranged to receive a first drive input; and
a variator coupled to the feed drive to provide a variable second drive input to the feed drive.

US Pat. No. 10,477,760

AGRICULTURAL ORGANIC DEVICE FOR WEED CONTROL

Underground Agriculture, ...

1. An agricultural system comprising:a frame linkage for attachment to an agricultural vehicle; and
at least one cutting device for cutting planted matter in a planted field, the cutting device being mounted to the frame linkage and positioned between respective adjacent rows of the planted matter in the field and including
a vertically-adjustable shaft having an upper end and a lower end, the upper end being the only portion of the at least one cutting device mounted directly to the frame linkage, and
a cutting unit attached to the lower end of the shaft, the cutting a rotatable blade for cutting the planted matter, including weeds, growing between the adjacent rows of the planted matter, the cutting unit being attached concentrically with a vertical axis of the shaft; and
at least one dedicated electric motor mounted to the upper end of the shaft for driving the rotatable blade of the cutting unit, the electric motor being external to the cutting unit.

US Pat. No. 10,477,755

IMPLEMENT WITH FOLDABLE TOOLBAR SYSTEM

UNVERFERTH MANUFACTURING ...

1. A method of operating an agricultural implement comprising a frame having a longitudinal axis and laterally opposed sides, a first wing carried by the frame, and at least one second wing, each second wing is pivotably connected to the first wing, the method comprising:(a) raising, by an elevator mechanism, the first wing and the second wing in a vertical direction from a lowered operating position to a raised operating position; and
(b) pivoting, by a wing pivot assembly comprising a skewed hinge, the second wing with respect to the first wing about a first pivot axis defined by the skewed hinge from the raised operating position to a transport position in one continuous motion;
wherein at the raised operating position, the second wing extends from the frame in a lateral direction with respect to the longitudinal axis, and at the transport position, the second wing extends alongside one of the opposed sides of the frame;
wherein the first pivot axis is oriented at an acute angle with respect to the longitudinal axis.

US Pat. No. 10,477,754

IMPROVEMENTS FOR FOLDING AN AGRICULTURAL MACHINE

ROTACON ENGINEERING LIMIT...

1. An agricultural machine configured to be drawn over a soil surface in a field or from place to place by a prime mover, the machine comprising:a frame or chassis carrying machinery support frames that are used to support selected agricultural equipment; and
a raised primary beam extending from a hitching point to which the prime mover is reversibly connected by a pivoted connection, to a rear trailer, the primary beam defining a median line of symmetry for the frame or chassis,
wherein the frame or chassis includes four beams connect together by four joints, each of the joints being pivotable about a separate vertical axis of rotation,
wherein the beams of the frame or chassis include a first secondary beam and a second secondary beam pivotally connected to each other and to the primary beam at a first one of the joints at a first end of each of the first secondary beam and second secondary beam,
the first secondary beam is pivotally connected at a second end by a second one of the joints along a first tertiary beam,
the second secondary beam is pivotally connected at a second end by the third one of the joints along a second tertiary beam,
a first end of the first tertiary beam is connected at a fourth one of the joints to a first end of the second tertiary beam,
the first tertiary beam is extended beyond the second joint along the entire length of a first machinery support frame and the second tertiary beam being extended beyond the third joint along the entire length of a second machinery support frame, and
the agricultural equipment is pivotally connected to the first machinery support frame and to the second machinery support frame.
US Pat. No. 10,477,803

PLANTS AND SEEDS OF CORN VARIETY CV691303

Monsanto Technology LLC, ...

1. A plant of corn variety CV691303, wherein representative seeds of corn variety CV691303 have been deposited under ATCC Accession No. PTA-125239.
US Pat. No. 10,477,806

INBRED CORN LINE 2EEXI2053

Agrigenetics, Inc., Indi...

1. Seed of corn inbred line designated 2EEXI2053, or a part thereof, representative seed of the line having been deposited under ATCC Accession No. PTA-124402.
US Pat. No. 10,477,807

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH814115

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH814115, produced by crossing a first plant of variety CV690087 with a second plant of variety CV644326, wherein representative seeds of said varieties CV690087 and CV644326 are deposited under ATCC Accession Nos. PTA-125238 and PTA-125218, respectively.
US Pat. No. 10,479,862

AMINE BASED POLYMER POLYOL STABILIZERS

Covestro LLC, Pittsburgh...

1. An ethylenically unsaturated macromer comprising the reaction product of:(a) an amine initiated polyether polyol having a hydroxyl functionality of 3 to 8, having a number average molecular weight of from 4000 to 15,000, and which comprises the reaction product of
(i) an amine compound having an amine functionality of from 1 to 6 and a number average molecular weight of from 60 to 1000, wherein said amine groups are selected from primary and/or secondary amine groups, and optionally from tertiary amine groups, with the proviso that one or more primary and/or secondary amine groups is also present;
with
(ii) an alkylene oxide;
with
(b) an ethylenically unsaturated compound which is present in an amount such there is at least 0.08 mole unsaturation/mole polyol present in the resultant macromer;
optionally, in the presence of
(c) a catalyst.
US Pat. No. 10,477,810

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH906071

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH906071, produced by crossing a first plant of variety CV749310 with a second plant of variety CV581707, wherein representative seeds of said varieties CV749310 and CV581707 are deposited under ATCC Accession Nos. PTA-124502 and PTA-125247, respectively.
US Pat. No. 10,479,863

METHOD FOR CYCLICALLY PREPARING POLYETHER POLYOL BY USING DMC CATALYST

1. A method of cyclically preparing a polyether polyol as a target polymer, the method comprising:polymerizing a low molecular-weight alcohol with an alkylene oxide to obtain a low molecular-weight polymer;
obtaining an intermediate-target polymer by a first process in a reactor, the first process facilitating a first reaction of the low molecular-weight polymer with the alkylene oxide while a first amount of the low molecular-weight alcohol is introduced into the reactor; and
obtaining the target polymer by a second process in the reactor using a first portion of the intermediate-target polymer,
wherein:
a second portion of the intermediate-target polymer is recycled for reproduction of the intermediate-target polymer,
a double metal cyanide (DMC) catalyst is used as a catalyst of the first reaction,
an acid is used as a promoter of the first reaction,
the intermediate-target polymer and the low molecular-weight polymer have a same average molecular weight,
the DMC catalyst is a double metal cyanide complex catalyst for ring opening in polymerization of epoxy,
the acid is one of a nitric acid, a phosphoric acid, and a sulfuric acid, or a mixture of any two or three thereof,
the alkylene oxide is one of a propylene oxide, a butylene oxide, a mixture of ethylene oxide and the propylene oxide, a mixture of an ethylene oxide and a butylene oxide, a mixture of the propylene oxide and the butylene oxide, and a mixture of the ethylene oxide, the propylene oxide and the butylene oxide,
the low molecular-weight alcohol is a monohydric alcohol or a polyhydric alcohol, the monohydric alcohol being one of an allyl alcohol or a butanol, the polyhydric alcohol being one of an ethylene glycol, a propylene glycol, a butylene glycol, and a glycerol, and
the first process comprises the following steps:
1a) introducing the low molecular-weight polymer into the reactor, the low molecular-weight polymer having been pre-added with the DMC catalyst and the acid;
1b) dewatering by a bubbling nitrogen for at least 10 minutes at a first temperature range of 100-175° C. under vacuum at a first pressure not higher than ?0.085 MPa;
1c) turning off the bubbling nitrogen and further vacuuming for at least 10 minutes;
2) introducing into the reactor the alkylene oxide in an amount that is no more than 20% by weight (wt %) of the low molecular-weight polymer;
3a) simultaneously and continuously introducing the alkylene oxide and the first amount of the low molecular-weight alcohol into the reactor, the reactor maintained at a second temperature range of 120-180° C. and at a second pressure not higher than 0.2 MPa;
3b) introducing at least 10 wt % of the alkylene oxide into the reactor after the introducing of the first amount of the low molecular-weight alcohol is completed;
3c) waiting until no substantial pressure drop is observed in the reactor; and
3d) discharging the reactor to obtain the intermediate-target polymer.
US Pat. No. 10,480,121

SHEET-LIKE ARTICLE

Toray Industries, Inc, T...

1. A sheet shaped article comprising a fibrous base material formed mainly of ultrafine fibers and impregnated with, as a binder, a polyurethane resin that meets requirements (I) and (II) below:(I) the polyurethane resin contains an oxycarbonyl group and a carbonate group as ester groups in an interior portion of a polymer chain forming the polyurethane resin, and
(II) the polyurethane resin contains a urethane group and, optionally, a urea group with a total content of 7.0 to 11.0 mass %.
US Pat. No. 10,479,865

PROCESS FOR THE PREPARATION OF SEVELAMER CARBONATE

Strides Shasun Limited, ...

1. A process for the preparation of Sevelamer carbonate, comprising:(a) contacting an aqueous alkaline solution of polyallylamine hydrochloride with epichlorohydrin at a pH of more than 12;
(b) maintaining the reaction mixture obtained in step (a) under stirring until the formation of gel;
(c) optionally washing the gel with at least one of water miscible solvent(s) and water;
(d) suspending the obtained gel in step (b) or step (c) in water;
(e) treating the suspension obtained in step (d) with carbon dioxide in water to obtain Sevelamer carbonate; and
(f) optionally washing the Sevelamer carbonate with at least one of water miscible solvent(s) and water.
US Pat. No. 10,481,153

INTEGRATED COMPOUND DISCOVERY SYSTEMS AND METHODS

Wake Forest University, ...

1. A sequencing device comprising:(a) a spatially addressable sequencing array, said array comprising a plurality of separate and discrete sequencing locations thereon, said separate and discrete sequencing locations contacted with at least one sequencing reagent;
(b) a plurality of different oligomers operably connected to said spatially addressable sequencing array at different ones of said separate and discrete sequencing locations;
(c) a tag sequence which is complementary to, and is hybridized to, each of said oligomers; and
(d) a candidate chemical operably connected to each of said tag sequences,
wherein each of said separate and discrete sequencing locations is a unique identifier for its corresponding oligomer
and wherein said tag sequence is a unique identifier for its connected candidate chemical.
US Pat. No. 10,479,873

METHOD OF PRODUCING POLYMER-IMPREGNATED BASE RESIN

SUMITOMO RUBBER INDUSTRIE...

1. A method of producing a polymer-impregnated base resin, the method comprising impregnating a base resin with a polymer solution that comprises a solvent able to swell the base resin,wherein the polymer is at least one selected from the group consisting of a homopolymer or copolymer of one or two or more hydrophilic monomers, and a copolymer of one or two or more hydrophilic monomers with an additional monomer(s), and
wherein at least one of the hydrophilic monomer is an alkoxyalkyl (meth)acrylate.
US Pat. No. 10,477,823

SOYBEAN VARIETY 01069720

Monsanto Technology LLC, ...

1. A plant of soybean variety 01069720, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-125861.
US Pat. No. 10,479,877

FILLER COMPOSITION AND POLYOLEFIN RESIN COMPOSITION

UBE MATERIAL INDUSTRIES, ...

1. A polyolefin resin composition comprising a polyolefin resin, fibrous basic magnesium sulfate particles and spherical silicon dioxide particles having an average particle diameter in the range of 0.001 to 0.5 ?m in which the polyolefin resin and fibrous basic magnesium sulfate particles are contained in a ratio by weight in the range of 99:1 to 50:50, and the spherical silicon dioxide particles are contained in an amount of 0.001 to 50 weight parts per 100 weight parts of the fibrous basic magnesium sulfate particles and/or in an amount of 0.0002 to 10 weight parts per 100 weight parts of the resin.
US Pat. No. 10,477,825

COTTON VARIETY PX339054W3FE

Phytogen Seed Company, LL...

1. A seed of cotton variety designated PX339054W3FE, or a regenerable part thereof, representative seed of the variety having been deposited under ATCC Accession No. PTA-123652 on Nov. 15, 2016.
US Pat. No. 10,479,881

RUBBER COMPOSITIONS CONTAINING VISCOSITY MODIFIER AND RELATED METHODS

Bridgestone Americas Tire...

1. A rubber composition comprising:a. 100 parts of at least one rubber;
b. at least one olefin copolymer viscosity modifier in an amount of 0.5 to 10 phr;
c. at least one reinforcing filler in an amount of 5 to 200 phr; and
d. a cure package,
wherein the at least one olefin copolymer viscosity modifier has a Mn of 2,000 to 1,000,000 grams/mole.
US Pat. No. 10,479,884

AQUEOUS COMPOSITION FOR HARD SURFACE APPLICATIONS WITH ENHANCED STABILITY

CHEMETALL U.S., INC., Ne...

1. An aqueous composition for hard surface applications comprising at least one lipophilic compound that is an oil and at least one copolymer, characterized in that the at least one copolymer is a comb-type branched copolymer exhibiting an alternating sequence of monomeric units (a) each having at least one hydrophilic group and monomeric units (b) each having at least one lipophilic side chain,wherein the at least one copolymer exhibits a molecular weight distribution the range of 1.2 to 3.0.
US Pat. No. 10,478,092

HYBRID REGISTRATION METHOD

Covidien LP, Mansfield, ...

1. A system for registering sensor location data to images of at least one body part, comprising:an endoscope including:
a sensor configured to generate data corresponding to a location of the sensor relative to at least one body part in a patient, and
an image sensor configured to generate image data; and
a computing device having a memory configured to store a plurality of previously acquired images of the at least one body part, and including thereon a software application that, when executed by the computing device,
displays a three-dimensional (3D) model derived from the plurality of previously acquired images,
detects a location of the sensor,
receives image data from the image sensor, and
registers the location of the sensor to a subgroup of images selected from the plurality of previously acquired images, wherein registration is achieved by parsing the plurality of previously acquired images based on the location data to generate the subgroup of the plurality of previously acquired images, and comparing images in the subgroup to images received from the image sensor to identify an image that substantially matches an image generated by the image sensor.
US Pat. No. 10,479,886

OPTICAL RESIN COMPOSITION AND FILM

KANEKA CORPORATION, Osak...

1. An optical resin composition comprising:99 to 50% by weight of an acrylic resin having a glass transition temperature of not lower than 110° C.; and
1 to 50% by weight of a particulate (meth)acrylic multilayer structure graft copolymer, wherein
the (meth)acrylic multilayer structure graft copolymer comprises:
an innermost layer made of a polymer containing not less than 90% by weight of a methacrylic acid ester as a first monomer;
a middle layer made of a polymer containing, as a second monomer, not less than 80% by weight of an acrylic acid alkyl ester having an alkyl group with 4 to 12 carbon atoms; and
an outermost layer made of a polymer containing a methacrylic acid ester as a third monomer, and
a graft ratio of the (meth)acrylic multilayer structure graft copolymer is not less than 110%,
wherein the optical resin composition has an adhesion to polyvinyl alcohol of not less than 2 N/25 mm.
US Pat. No. 10,479,887

BIODEGRADABLE POLYESTER COMPOSITION

Zhuhai Wango Chemical Co....

1. A biodegradable polyester composition, characterized in that, it comprises following components in parts by weight:i) 60 to 100 parts of biodegradable aliphatic-aromatic polyester;
ii) 0 to 40 parts of polylactic acid;
iii) 0 to 35 parts of an organic filler and/or an inorganic filler; and
iv) based on a total weight of the biodegradable polyester composition, a weight content of glycidyl methacrylate is 0.05 ppm-10 ppm, for enhancing compatibility between the aliphatic-aromatic polyester and the polylactic acid to increase surface property and decrease fisheyes in the biodegradable polyester composition when processed into a film.
US Pat. No. 10,479,888

POLYBUTYLENE TEREPHTHALATE COMPOSITION WITH IMPROVED HYDROLYTIC STABILITY

SABIC GLOBAL TECHNOLOGIES...

1. A thermoplastic composition with improved hydrolytic stability, comprising:10 to 30 percent by weight of polybutylene terephthalate (PBT) having a carboxylic end group concentration (CEG) of 40 to 50 mmol/kg, and an intrinsic viscosity of 1.15 to 1.25 dl/g as measured in a 60:40 phenol/tetrachloroethane;
30 to 50 percent by weight of a polybutylene terephthalate (PBT) having a carboxylic end group concentration (CEG) of 50 to 120 mmol/kg and an intrinsic viscosity of 0.63 to 0.68 dl/g as measured in a 60:40 phenol/tetrachloroethane;
25 to 35 weight percent of a reinforcing filler;
0.01 to 0.1 percent by weight of a catalyst;
0.01 to 5 percent by weight of an epoxy chain extender;
0.01 to 0.1 percent by weight of a hindered phenol stabilizer; and
0.1 to 10 percent by weight of a mold release agent;wherein all weight percents are based on the total weight of the composition; andwherein the melt volume flow rate as measured by ISO 1133 at 250° C. with 5 kg load and 300 s dwell time of the thermoplastic composition when subjected to 80° C. and 70 percent room humidity after 500 hours is between 52 and 62 cm3/10 min, and the melt volume flow rate percent change compared to an initial melt volume flow rate of the thermoplastic composition is between 20 and 40 percent.
US Pat. No. 10,479,123

SECURITY FEATURE AND DOCUMENT OF VALUE

1. A security feature for securing value documents, comprising a chemically unstable inorganic feature substance and a stabilizing component comprising a substance that stabilizes the feature substance, said substance having at least the same solubility in water as the feature substance to be protected and releasing ions when said substance is decomposed, which ions conform to the ions of the feature substance at least in part.
US Pat. No. 10,479,892

FUNCTIONAL GROUP ASPHALT MODIFIERS, METHODS OF MODIFYING ASPHALT, ASPHALT COMPOSITIONS AND METHODS OF MAKING

Lehigh Technologies, Inc....

1. An asphalt comprising:ground tire rubber;
a first component comprising a petroleum asphalt; and,
a second component comprising particles formed from a melted mixture of a resin and a binder;
wherein, the second component is dispersed within the first component;
wherein the resin comprises polypropylene and polymers having glycidyl functionality; and,
wherein the binder comprises polyethylene by-product waxes.
US Pat. No. 10,477,842

HUMANIZED IL-4 AND IL-4R? ANIMALS

REGENERON PHARMACEUTICALS...

1. A triply humanized mouse, comprising(i) a replacement of a genomic DNA of a mouse IL-4R? gene at an endogenous mouse IL-4R? locus with a human genomic DNA of a human IL-4R? gene to form a humanized IL-4R? gene, wherein the genomic DNA of the mouse IL-4R? gene comprises the ATG initiation codon of exon 1 through exon 5 of the mouse IL-4R? gene, and the human genomic DNA of the human IL-4R? gene comprises the ATG initiation codon of exon 1 through exon 5 of the human IL-4R? gene, wherein the humanized IL-4R? gene comprises the ATG initiation codon of exon 1 through exon 5 of the human IL-4R? gene and exons 6-9 of the mouse IL-4R? gene, wherein expression of the humanized IL-4R? gene is under control of the mouse IL-4R? promoter at the endogenous mouse IL-4R? locus,
(ii) a replacement of a genomic DNA of a mouse IL-4 gene at an endogenous mouse IL-4 locus with a genomic DNA of a human IL-4 gene to form a humanized IL-4 gene, wherein the genomic DNA of the mouse IL-4 gene comprises the ATG initiation codon of exon 1 through exon 4 of the mouse IL-4 gene, and the genomic DNA of the human IL-4 gene comprises the ATG initiation codon of exon 1 through exon 4 of the human IL-4 gene, and wherein expression of the humanized IL-4 gene is under control of the mouse IL-4 promoter at the endogenous mouse IL-4 locus, and
(iii) a replacement of a genomic DNA of a mouse IL-33 gene at an endogenous mouse IL-33 locus with a genomic DNA of a human IL-33 gene such that the locus encodes a human IL-33 but not mouse IL-33.
US Pat. No. 10,479,895

LIQUID REPELLENT SURFACES

United States of America ...

1. A method of making a liquid repellent coating on a non-porous surface, the method comprising:combining a fluoropolymer with a polymer, the polymer being poly(ethyl methacrylate), poly(butyl methacrylate), or both, to form a mixture; and
applying the mixture to the non-porous surface to form a coating thereon, the coating being hydrophobic and oleophobic.
US Pat. No. 10,479,902

DURABLE AND FLEXIBLE INK COMPOSITION FOR HIGH-QUALITY/HIGH-DEFINITION SCREEN PRINTING, PRINTED PRODUCT OBTAINED BY SCREEN PRINTING SAID INK COMPOSITION, AND MANUFACTURING METHOD FOR SAID PRINTED PRODUCT

TEIKOKU PRINTING INKS MFG...

1. An ink composition for screen printing to be used on a thermoplastic resin substrate, the ink composition comprising:at least one solvent having a boiling point of not less than 170° C. and that is selected from the group consisting of butylcellosolve acetate, dialkyl adipate ester, isophorone, 3-methoxy-3-methylbutanol, 3-methoxy-3-methylbutyl acetate, coal tar naphtha, diethyleneglycol monoethyl ether, diethyleneglycol monoethyl ether acetate, diethyleneglycol monobutyl ether, triethyleneglycol monobutyl ether, triethyleneglycol monobutyl ether acetate, (meth)acrylate monomer, a vinyl ether monomer, and an amide monomer, wherein the amount of the at least one solvent having a boiling point of not less than 170° C. is not less than 70 mass % of a total weight of all solvent in the ink composition; and
at least one thermoplastic polymer that can produce printed matter and has a weight-average molecular weight in the range of 4000 to 100,000, and a Tg (softening point) of 20 to 95° C., wherein the amount of the at least one thermoplastic polymer in the ink composition is in the range of 10 mass % to 70 mass % with respect to a total weight of the ink composition, and wherein the at least one thermoplastic polymer is selected from the group consisting of polyester resins, vinyl chloride-vinyl acetate copolymer resins, butyral resins, polyether-urethane resins, polyester-urethane resins, polycarbonate-urethane resins, epoxy resins, phenol resins, acrylic resins, polyamide resins, polyamideimide resins, polyolefin resins, chlorinated polyolefin resins, chlorinated rubber, melamine resins, urea resins, modified cellulose resins, rosin resins, maleic acid resins, natural resins, alkyd resins, and combinations thereof,
wherein:
the ink composition has:
a viscosity of 5 to 180 Pas as measured with a BH-type rotating viscosimeter at 25° C.,
a thixotropic index (TI value) of 2.0 to 8.0, and
a measured flow radius value between 13.0 to 24.0 mm after 1 minute from a start of measurement by a flow property measuring method using a spread meter at 25° C. according to JIS K5701-1:2000,
the ink composition satisfies an inequality “F60”?“F45”?1.0 mm, wherein “F60” is defined as the measured flow radius value after 1 minute and “F45” is defined as the measured flow radius value after 45 seconds from the start of measurement by a flow property measuring method using a spread meter,
the ink composition is adapted to produce printed matter in a single step comprising both a solid image pattern and a fine image pattern with the spreading width of no more than 10 ?m from image design dimensions of a printing plate at one of edges and outlines of any section in a printed image, for avoiding a visible state of enlarged sections of the printed image and a halated printed image, when producing printed matter by screen printing onto a thermoplastic resin substrate using a 360-mesh screen printing plate formed by a high-strength, non-deforming stainless steel mesh with a filament diameter of 25 ?m, the thermoplastic resin substrate being a flat base material selected from the group consisting of polycarbonate resin, treated or untreated polyester resin, acrylic resin, vinyl chloride resin, polypropylene resin, polyethylene resin, and combinations thereof, and
the ink composition, when applied, produces a printed image coating film having an elongation percentage according to comparison between a length before shaping and a length after shaping by heating in a range between about 150° C. to 190° C. of the printed image, of not less than 250% under vacuum forming or pressure forming.
US Pat. No. 10,479,908

METHOD OF MANUFACTURING HARD COAT FILM

FUJIFILM Corporation, To...

1. A composition, which is a photopolymerizable hard coating composition comprising:a radical polymerizable compound having two or more radical polymerizable groups selected from the group consisting of acryloyloxy groups, acryloyl groups, methacryloyloxy groups, and methacryloyl groups per molecule;
a cationic polymerizable compound;
a radical photopolymerization initiator; and
a cationic photopolymerization initiator,
wherein the cationic polymerizable compound comprises a cyclic structure-containing compound,
wherein the cyclic structure-containing compound contains a nitrogen-containing hetero ring-containing compound, and
wherein the nitrogen-containing hetero ring-containing compound contains one or more nitrogen-containing hetero ring selected from the group consisting of isocyanurate rings and glycoluril rings per molecule.
US Pat. No. 10,479,909

BIRD-REPELLENT COATING MATERIAL

WINTON OSAKA CO., LTD., ...

1. A bird-repellent coating material comprising:a microencapsulated aqueous dispersion of a visual repellent against birds; and
an aqueous resin vehicle,
wherein the microencapsulated aqueous dispersion of the visual repellent against birds is incorporated into the aqueous resin vehicle.
US Pat. No. 10,479,910

PRIMER COMPOSITION, ADHERING METHOD, AND ELECTRIC/ELECTRONIC PART

Dow Toray Co., Ltd., Tok...

1. An article comprising a base material, a silicone cured product, and a primer layer adhering the silicone cured product to the base material,wherein the primer layer comprises the reaction product of a primer composition comprising:
(A) an organosiloxane block copolymer represented by the average unit formula:
(R12SiO2/2)a(R2SiO3/2)b
wherein each R1 and R2 is independently an alkyl group having 1 to 12 carbon atoms, an aryl group having 6 to 20 carbon atoms, or an aralkyl group having 7 to 20 carbon atoms, “a” is a number in the range of 0.40 to 0.90, “b” is a number in the range of 0.10 to 0.60, and “a+b”=1.00, having 0.5 to 35.0 mol % of silicon atom-bonded hydroxyl groups or silicon atom-bonded alkoxy groups, in addition to being a solid at 25° C. and having a softening point of 200° C. or lower, in which resinous siloxane blocks represented by the formula:
[R2SiO3/2]
wherein R2 is the same as above, are connected by linear siloxane blocks represented by the formula:
—(R12SiO2/2)n—
wherein R1 is the same as above, and “n” is a number in the range of 10 to 400;
(B) a curing catalyst, in an amount to promote curing of this composition; and
(C) an organic solvent; and
wherein the silicone cured product comprises the reaction product of a curable silicone composition different from the primer composition.
US Pat. No. 10,479,914

CONDUCTIVE PARTICLE AND PREPARATION METHOD THEREOF, CONDUCTIVE ADHESIVE AND DISPLAY DEVICE

BOE TECHNOLOGY GROUP CO.,...

1. A method of preparing conductive particles, comprising the steps of:forming spherical cores comprising silica;
dispersing the spherical cores in deionized water and adding organic polymeric monomers so as to form a reaction solution, wherein the organic polymeric monomer is one or more selected from the group consisting of acrylonitrile, 2,3-dimethyl acrylonitrile, 3-phenyl-2-acrylonitrile, and 2-methoxymethyl-3-methoxy acrylonitrile, and a mass ratio of the organic polymeric monomers to the spherical cores ranges from 0.5:1 to 2:1;
radiating the reaction solution with ? rays so that the organic polymeric monomers are polymerized on surfaces of the spherical cores so as to form organic polymers;
separating the spherical cores from the reaction solution so as to obtain the spherical cores formed with the organic polymers on their surface; and
carrying out preoxidation and carbonization treatment successively on the spherical cores formed with the organic polymers on their surfaces so that the organic polymers form a conductive layer consisting of carbon particles, thereby obtaining the conductive particles each consisting of the conductive layer and the spherical core.
US Pat. No. 10,477,862

IN SITU GENERATION OF PEROXYCARBOXYLIC ACIDS AT ALKALINE PH, AND METHODS OF USE THEREOF

Ecolab USA Inc., Saint P...

1. A peroxycarboxylic acid forming composition formed by a method comprising:combining an oxidizing agent with a source of alkalinity;
adding a first reagent comprising an ester of a polyhydric alcohol and a C8 carboxylic acid;
allowing the peroxycarboxylic acid composition to react for a sufficient amount of time such as a C8 peroxycarboxylic acid is formed; and thereafter
adding a second reagent comprising an ester of a polyhydric alcohol and a C2 carboxylic acid; and
optionally further adding one or more agents, wherein the one or more agents are a dispersing agent, and/or a solvent;
wherein the first and second reagents have an HLB value of 3 or greater; and
wherein the composition is not at equilibrium and has a pH greater than 12.
US Pat. No. 10,481,456

ELECTROCHEMICAL ENERGY STORAGE DEVICES

GENTEX CORPORATION, Zeel...

5. A energy storage device comprising:a first cell comprising an anodic material in an activated state;
a second cell comprising a cathodic material in an activated state;
a porous separator isolating the first cell from the second cell; and
wherein:
the anodic material is a phenazine, a phenothiazine, a triphenodithiazine, a carbazole, a indolocarbazole, a biscarbazole, or a ferrocene;
the cathodic material is a viologen; and
the energy storage device exhibits an open circuit voltage of about 0.2 V to about 1.2 V.
US Pat. No. 10,482,994

METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS

Sequenom, Inc., San Dieg...

1. A computer-implemented method for determining fetal fraction based on a copy number variation in a maternal genome, comprising:(a) sequencing a test sample from a pregnant female bearing a fetus by a non-targeted massively parallel sequencing process that generates nucleotide sequence reads, the test sample comprising circulating cell-free nucleic acid from (i) a maternal genome and (ii) a fetal genome; mapping the sequence reads to genomic sections of a reference genome; and counting the sequence reads mapped to the genomic sections of the reference genome, thereby obtaining counts of sequence reads mapped to the genomic sections of the reference genome;
(b) normalizing, using a microprocessor, the counts mapped to the genomic sections of the reference genome, thereby providing normalized counts for the genomic sections;
(c) identifying a first elevation of the normalized counts for a first set of genomic sections significantly different than a second elevation of the normalized counts for a second set of genomic sections, wherein the first set of genomic sections and the second set of genomic sections are within the same chromosome;
(d) determining a copy number variation in the maternal genome for the first set of genomic sections based on the identified first and second elevations;
(e) determining a categorization for the copy number variation in the maternal genome by comparing the first elevation to expected elevations for predetermined copy number variation categorizations; and
(f) determining, using a microprocessor, a fetal fraction of the circulating cell-free nucleic acid according to the first elevation and a deviation from an expected elevation of normalized counts for the categorization.
US Pat. No. 10,477,865

FUNGICIDAL COMPOUNDS AND METHODS OF THEIR USE

Auckland UniServices Limi...

1. A method of treating or reducing risk of a fungal infection in a subject in need thereof comprising administering to said subject a composition comprising an effective amount of Epicoccum purpurascens strain SVB-F1 on deposit at the National Measurement Institute, Australia (NMI) under accession number V10/000331 or an extract, an exudate or isolate thereof, and an agriculturally or a pharmaceutically acceptable carrier wherein the carrier is a solid carrier.
US Pat. No. 10,477,866

GOOSE AND COOT REPELLENT AND METHOD FOR REPELLING GEESE, COOTS AND OTHER BIRDS

1. A composition for repelling geese comprising:a mixture of peanut hulls in granular form, cedar oil, thyme oil, cinnamon oil, castor oil, fish oil, garlic oil and white pepper wherein said mixture emits odor that is offensive to repels geese; wherein ingredients of the mixture are included in the following amounts:
89.29 percent by weight peanut hulls;
1.25 percent by weight cedar oil;
0.60 percent by weight thyme oil;
0.55 percent by weight cinnamon oil;
4.0 percent by weight castor oil;
1.0 by weight fish oil;
0.06 by weight garlic oil; and
2.25 by weight white pepper.
US Pat. No. 10,477,876

DRINK COMPOSITION PREPARED FROM COFFEE BEAN OF TREE CULTIVATED WITH RED GINSENG POWDERED EXTRACT

TROY CO., LTD., (KR)

1. A drink composition containing as an active ingredient, a coffee bean powdered extract containing ginsenoside removed of more than one hydroxyl group which is manufactured by cultivating a coffee tree by using a red ginseng powdered extract, comprising: resting a coffee seed by dipping the coffee seed in an aqueous solution of the red ginseng powdered extract for a predetermined period of time to produce a rested coffee seed; wherein the aqueous solution of the red ginseng powdered extract includes ginsenoside as the active ingredient, and wherein the ginsenoside has more than one hydroxyl group removed by passing the aqueous solution of red ginseng powdered extract through a semipermeable membrane wherein a hydrogen ion has been introduced to the semipermeable membrane from outside through a hydrogen ion supply route.
US Pat. No. 10,483,008

PROCESS FOR THE PURIFICATION OF GA-68 FROM ELUATE DERIVING FROM 68GE/68GA GENERATORS AND CHROMATOGRAPHIC COLUMNS FOR USE IN SAID PROCESS

Advanced Accelarator Appl...

1. Process for the preparation of a radiopharmaceutical containing 68Ga wherein a solution of eluates from 68Ge/68Ga generators is passed through a column for chromatography purification comprising a stationary phase of silica having a granulometry less than 100 microns and thereafter the solution collected from the column is directly poured in a container containing a labeling kit, the labeling kit comprising a substrate to be labeled with 68Ga, wherein the substrate subsequently labeled with 68Ga is the radiopharmaceutical.
US Pat. No. 10,477,880

FROZEN CONFECTIONERY PRODUCTS

Societe des Produits Nest...

1. A frozen confectionery product obtained by a method comprising:subjecting a composition having a pH between 5.8 and 6.5 and comprising at least 7 wt. % of dairy protein comprising a protein source selected from the group consisting of liquid fresh milk, milk powder, standardised milk powder, skimmed milk powder, acid casein, sodium caseinate, and combinations thereof to a heat treatment at a temperature between 120° C. and 140° C. for a time period of 5 seconds to 30 seconds to at least partially form protein aggregates comprising casein and whey protein, wherein at least 30 wt. % of the dairy protein in the composition is converted to the protein aggregates by the heat treatment of the composition;
mixing the heat treated composition with further ingredients to form an ice confectionery mix;
pasteurizing the ice confectionery mix; and
freezing the pasteurized ice confectionery mix to form the frozen confectionery product, wherein the frozen confectionery product has an average equivalent diameter of fat globules below 10 microns, the protein aggregates comprising casein and whey protein are 0.5 wt. % to 4 wt. % of the frozen confectionery product, the casein protein is covalently bonded to the whey protein in the protein aggregates, and the frozen confectionery product has a smooth and creamy texture.
US Pat. No. 10,478,652

METHOD FOR BIODEGRADING HIGH MOLECULAR WEIGHT POLYCYCLIC AROMATIC HYDROCARBON PYRENES WITH HALOPHILIC BACTERIA

King Fadh University of P...

1. A method for degrading a polycyclic aromatic compound (PAH) comprising:pumping groundwater or other liquid contaminated with one or more PAHs into a bioreactor to which one or more bacteria of the genus Halomonas have been added,
contacting said groundwater or other liquid in the bioreactor with the one or more bacteria in a medium containing NaCl at a temperature of at least 15° C. for a time sufficient to degrade the PAH;
wherein said Halomonas have 16s ribosomal RNA that is at least 95% identical to SEQ ID NO: 1.
US Pat. No. 10,478,397

AVIAN TINCTURE

1. A method for producing a tincture formula comprising:(i) creating a plurality of tinctures, each of the plurality of tinctures produced by:
a) mixing a ratio of at least one herb with a liquid including 190 proof neutral organic grain alcohol diluted with water into a first container, wherein the herb is a fresh herb or a dried herb;
b) sealing the first container to provide an air tight environment;
c) shaking the mixture 2-3 times a day for 2 weeks;
d) straining the herb material to separate it from the liquid mixture;
e) pouring the liquid mixture into a second container; and
f) sealing the second container containing the liquid mixture and storing it; and
(ii) combining the plurality of tinctures to produce the tincture formula,
wherein the plurality of tinctures includes: a tincture of Achillea millifolium(Yarrow) mixed with a liquid of 50% alcohol and 50% water, a tincture of Hypericum perforatum (St. John's Wort) mixed with a liquid of 50% alcohol and 50% water, a tincture of Anemopsis californicum (Yerba Mansa) mixed with a liquid including 60% alcohol and 40% water, a tincture of Rumex crispus (Yellow Dock) mixed with a liquid of 50% alcohol and 50% water, and a tincture of capsicum (Cayenne) mixed with a liquid including 95% alcohol and 5% water;
wherein the tincture formula composition contains 4 parts Yarrow, 4 parts St. John's Wort, 2 parts Yerba Mansa, 1 part Yellow Dock, and 1 part Cayenne;
wherein the tincture formula is configured to treat bumblefoot in avian species and dissolves abscesses free of invasive lancing or cutting open of infected areas; and
wherein the tincture formula further relieves inflamed and swollen leg joints in the avian species.
US Pat. No. 10,478,398

SOL-GEL PHASE-REVERSIBLE HYDROGEL TEMPLATES AND USES THEREOF

Akina, Inc., West Lafaye...

1. A method of making drug-containing microparticles comprising:(a) filling a plurality of wells provided in a preformed, dissolvable hydrogel mold with a non-aqueous composition comprising: at least one drug, a non-water soluble, biodegradable polymer comprising poly(lactic co-glycolic acid) polymer (PLGA) and non-aqueous solvent, which dissolvable hydrogel mold is formed of a sol-gel phase reversible hydrogel comprising gelatin;
(b) solidifying the composition in the plurality of wells by evaporating the non-aqueous solvent, thereby forming microparticles; and
(c) harvesting the microparticles from the preformed dissolvable hydrogel mold by dissolving the hydrogel mold in an aqueous solution.
US Pat. No. 10,479,936

PHOSPHOR AND METHOD FOR PRODUCING THE PHOSPHOR

OSRAM OPTO-SEMICONDUCTORS...

1. A phosphor having the general molecular formula (MB)Li3?2x**Al1+2x**O4?4x**N4x**:E, wherein0
US Pat. No. 10,478,399

MODIFIED RELEASE TABLET COMPOSITION COMPRISING MIRABEGRON

Synthon B.V., Nijmegen (...

1. A modified release tablet composition comprising:a) 5 to 25 wt % with respect to the total weight of the uncoated tablet of a therapeutically effective dose of mirabegron or a pharmaceutically acceptable salt thereof; and
b) polyethylene oxide (PEO) having an average molecular weight of approximately 7,000,000 or a viscosity of 7500 to 10000 cps at a 1% aqueous solution at 25° C. and polyethylene glycol (PEG) having an average molecular weight of approximately 6000 to 10000, wherein the weight ratio PEO to PEG ranges from 1:3 to 1:4.5;
wherein said tablet exhibits an in vitro dissolution profile that meets the following release criteria: 15%-35% of mirabegron is released within 1 hour, at least 50% of mirabegron is released within 2 hours, and at least 90% of mirabegron is released within 3 hours, wherein said dissolution profile is measured in 250 ml phosphate buffer (pH 6.8) using USP apparatus 3 at 20 dpm and 37° C.
US Pat. No. 10,479,937

NARROW BAND RED PHOSPHOR

Intematix Corporation, F...

1. A red-emitting phosphor, comprising:phosphor particles with a composition represented by the chemical formula MSxSeyAz:Eu, wherein
M is at least one of Mg, Ca, Sr and Ba;
A comprises one or more of carbon, nitrogen, boron, phosphorous and a monovalent combining group NCN (cyanamide);
x?0;
y?0.1;
0 0.8
US Pat. No. 10,478,402

SOLID NANOPARTICLE WITH INORGANIC COATING

Nanexa AB, Uppsala (SE)

1. A method of preparing a controlled or delayed release pharmaceutical composition comprising:i. a plurality of coated particles of a size that is from 0.1 ?m to 50 ?m, said coated particles having a solid core comprising a biologically active substance, said solid core being enclosed by one or more metal oxide materials; and
ii. a pharmaceutically acceptable carrier,
the method comprising the sequential steps of:
(1) applying an initial coating of at least one metal oxide to said solid cores in an atomic layer deposition reactor;
(2) discharging the coated particles from the reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1);
(3) reintroducing the disaggregated, coated particles from step (2) into an atomic layer deposition reactor and applying a further coating of at least one metal oxide to the reintroduced particles;
(4) optionally repeating steps (2) and (3) one or more times to increase total thickness of the one or more metal oxide materials that enclose said solid core; and
(5) admixing said coated particles obtained from step (3) or step (4) with said pharmaceutically acceptable carrier to form said pharmaceutical composition.
US Pat. No. 10,481,483

LITHOGRAPHY MASK AND METHOD

Taiwan Semiconductor Manu...

1. A photomask comprising:a substrate over a first conductive layer, the substrate formed of a low thermal expansion material (LTEM);
a second conductive layer over the first conductive layer;
a reflective film stack over the substrate;
a capping layer over the reflective film stack;
an absorption layer over the capping layer; and
an antireflection (ARC) layer over the absorption layer, wherein the ARC layer and the absorption layer have a plurality of openings in a first region exposing the capping layer, wherein the ARC layer, the absorption layer, the capping layer, and the reflective film stack have a trench in a second region exposing the second conductive layer.
US Pat. No. 10,478,410

PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN®

United Therapeutics Corpo...

1. A method of preparing a pharmaceutical batch of a salt of treprostinil that can be stored as a stable compound at ambient temperature, said pharmaceutical batch being at least 2.9 grams, the method comprising (a) alkylating a benzindene triol, (b) hydrolyzing the product of step (a) to form a solution comprising treprostinil, (c) contacting the solution comprising treprostinil from step (b) with a base to form a salt of treprostinil, wherein forming the salt of step (c) reduces the amount of one or more impurities resulting from steps (a) and/or (b) in the pharmaceutical batch.
US Pat. No. 10,478,413

DERMAL THERAPEUTIC SYSTEM WITH HIGH ADHESIVITY

FIDIA FARMACEUTICI S.P.A....

1. A dermal therapeutic system which comprises an adhesive polymeric matrix comprisingan acrylate-vinyl acetate copolymer having a Tg below 0° C., which contains free hydroxyl groups, said acrylate-vinyl acetate copolymer being present in a percentage ranging from 45 to 65% by weight with respect to the total dry weight of the adhesive polymeric matrix and a basic butylated methacrylate copolymer, said basic butylated methacrylate copolymer being present in a percentage ranging from 5 to 20% by weight with respect to the total dry weight of the adhesive polymeric matrix, as adhesive components,
an organic or inorganic acid in a percentage ranging from 0.5 to 3.5% by weight with respect to the total dry weight of the adhesive polymeric matrix, as stabilizer,
a salt of Diclofenac in a percentage ranging from 8 to 20% by weight with respect to the total dry weight of the adhesive polymeric matrix, as active principle,
an adhesion modulator in a percentage ranging from 10 to 30% by weight with respect to the total dry weight of the adhesive polymeric matrix, and
the complement to 100 consisting of excipients and/or pharmaceutically acceptable additives,
wherein said dermal therapeutic system does not allow said salt of Diclofenac to exert a systemic action,
wherein the acrylate-vinyl acetate copolymer having a Tg below 0° C., containing free hydroxyl groups, is a self-curing acrylate-vinyl acetate copolymer having a Tg lower than 0° C., containing free hydroxyl groups and without free carboxyl groups or a non-curing acrylate-vinyl acetate copolymer having a Tg lower than 0° C., containing free hydroxyl groups and without free carboxyl groups;
wherein the salt of Diclofenac is selected from the group consisting of alkaline metal salts of Diclofenac, hydroxyethylpyrrolidine salt of Diclofenac, and diethylammonium salt of Diclofenac;
wherein the inorganic acid is hydrochloric acid;
wherein the organic acid is selected from the group consisting of citric acid, succinic acid, lactic acid, maleic acid, fumaric acid, salicylic acid, acetic acid, and a mixture thereof;
wherein the adhesive polymeric matrix has a thickness ranging from 50 to 500 microns and
wherein the dermal therapeutic system has a surface ranging from 20 to 300 cm2.
US Pat. No. 10,483,546

USE OF XANTHAN GUM AS AN ANODE BINDER

National Research Council...

1. An electrode consisting essentially of: an electrode active material into which lithium is intercalated, a conductive carbon, and a binder; wherein the electrode active material is an oxide, or a homogeneous matrix of an oxide and a conductive carbon, and wherein the binder comprises xanthan gum.
US Pat. No. 10,478,416

COMPOSITIONS AND METHODS FOR PREVENTING AND RECOVERY FROM DETRIMENTAL EFFECTS OF ALCOHOL CONSUMPTION

Cheers Health, Inc., Kin...

1. A tablet or capsule for mitigating the adverse effects of alcohol consumption in a human consisting essentially of at least 98% pure dihydromyricetin, N-acetyl cysteine, prickly pear extract, and at least 80% pure silymarin.
US Pat. No. 10,481,494

COATING COMPOSITIONS FOR USE WITH AN OVERCOATED PHOTORESIST

Rohm and Haas Electronic ...

8. An antireflective composition for use with an overcoated photoresist composition, the antireflective composition comprising a polyester resin that comprises 1) one or more parabanic acid moieties and 2) one or more polymerized tris(hydroxyl ethyl)isocyanurate groups.
US Pat. No. 10,478,419

USE OF DAPHNORETIN IN PREVENTION OF TISSUE OR ORGAN TRANSPLANT REJECTION OR GRAFT-VERSUS-HOST-DISEASE

MACKAY MEMORIAL HOSPITAL,...

1. A method for treating a tissue or organ transplant rejection or graft-versus-host disease (GVHD) in a subject in need thereof comprising administering to the subject an effective amount of daphnoretin.
US Pat. No. 10,479,701

PRODUCTION OF ULTRA-HIGH-DENSITY BRINES USING TRANSIENTLY-OPERATED DESALINATION SYSTEMS

Gradiant Corporation, Wo...

1. A method for producing a concentrated brine stream, comprising:supplying a liquid stream comprising water and a dissolved salt at an initial concentration to a fluidic circuit comprising a humidifier, wherein the humidifier removes at least a portion of the water from the liquid stream to produce a concentrated brine stream comprising water and the dissolved salt at a second concentration higher than the initial concentration of the liquid stream; and
recirculating the concentrated brine stream through the fluidic circuit to remove at least a portion of the water from the concentrated brine stream, forming a recirculated concentrated brine stream comprising water and the dissolved salt at a third concentration higher than the second concentration of the concentrated brine stream;
wherein, during the recirculating, an amount of solid salt is produced within the fluidic circuit.
US Pat. No. 10,479,960

FIBROUS STRUCTURES COMPRISING A SURFACE SOFTENING COMPOSITION

1. A fibrous structure comprising a plurality of wood pulp fibers, wherein the fibrous structure comprises a surface comprising a non-transferable surface softening composition comprising a metathesized unsaturated polyol ester having one or more of the following properties:(i) a weight average molecular weight of from about 5,000 Daltons to about 50,000 Daltons;
(ii) an oligomer index from greater than 0 to 1; and
(iii) an iodine value of from about 30 to about 200;wherein the surface softening composition further comprises a quaternary ammonium compound;wherein the surface softening composition comprises from about 5% to about 40% by weight of the quaternary ammonium compound;wherein the fibrous structure comprises from about 0.1% to about 2% of a total basis weight of the surface softening composition; andwherein the fibrous structure exhibits an average TS7 Softness Value of less than 9.
US Pat. No. 10,483,555

FUEL CELLS USING VERTICALLY FREE STANDING GRAPHENE AND CARBON NANOSHEETS

1. A fuel cell, comprising:a cathode;
an anode; and
an electrolyte,
wherein a plurality of vertically free-standing graphene-containing carbon nanosheets, of which the thickness is 2 nanometers or less, having a base layer of planar one to seven atomic layers graphene materials, having folded and crumpled topological structure, grow up on surfaces of the cathode and/or the anode, by a plasma technology.
US Pat. No. 10,479,711

COMPOSITION WITH A TIME RELEASE MATERIAL FOR REMOVING HALOGENATED HYDROCARBONS FROM CONTAMINATED ENVIRONMENTS

REMEDIATION PRODUCTS, INC...

1. A remediation composition, comprising:a first set of one or more organisms able to degrade at least one halogenated compound; and
a time release compound, combined with the first set of one or more organisms, comprising:
at least one of a polyamide and a polysaccharide; and
a second set of one or more organisms mixed with the at least one of a polyamide and a polysaccharide, wherein the second set of one or more organisms degrades, over a period of time, the at least one of a polyamide and a polysaccharide into smaller molecules or compounds that donate electrons for use by the first set of one or more organisms during degradation of the halogenated compound and wherein the period of time has a length of at least 20 days,
wherein the remediation composition further comprises a composition comprising activated carbon impregnated with elemental iron, and
wherein the elemental iron is impregnated into the activated carbon by being at least partially dissolved into walls of pores of the activated carbon.
US Pat. No. 10,479,969

UTILIZATION OF WASTEWATER FOR MICROALGAL CULTIVATION

PHYCOIL BIOTECHNOLOGY INT...

1. A method for cultivating a microalgae capable of heterotrophic growth by providing a light signal to initiate a light-activated metabolism, comprising:incubating the microalgae under a heterotrophic growth condition for a period of time sufficient to allow the microalgae to grow, wherein the heterotrophic growth condition comprises a media comprising a fruit wastewater, and wherein the heterotrophic growth condition further comprises light having a wavelength between 360 and 700 nm, required to initiate the light-activated metabolism, and the intensity of the light is less than 0.8 ?mol photons/m2s,
wherein the light-activated metabolism includes a life cycle, a circadian rhythm, cell division, a biosynthetic pathway, or a transport system,
wherein the microalgae is a Botryococcus sudeticus (UTEX 2629) strain or a Neochloris oleabundans (UTEX 1185) strain,
wherein the irradiation of the light is applied in a cyclic pattern of light and dark at a ratio between 6 hours (light): 18 hours (dark) or 23 hours (light): 1 hours (dark).
US Pat. No. 10,479,974

METHOD, DEVICE AND KIT FOR MASS CULTIVATION OF CELLS USING POLYIMIDE POROUS MEMBRANE

UBE INDUSTRIES, LTD., Ya...

1. A mass cell culturing method including:(1) applying cells to a porous polyimide film, and
(2) applying the porous polyimide film to which the cells have been applied, to a cell culture medium and performing culturing the porous polyimide film to which the cells have been applied, until the number of cells reaches 1.0×106 or more per milliliter of medium, or until the number of cells per square centimeter of the porous polyimide film reaches 1.0×105,
wherein the porous polyimide film has a multilayer structure having at least two surface layers (an A-surface and a B-surface), and a macro-void layer sandwiched between the two surface layers,
a mean pore size of the holes in the A-surface is smaller than a mean pore size of the holes in the B-surface, and
the macro-void layer has a partition bonded to the surface layers (the A-surface and the B-surface), and a plurality of macro-voids surrounded by the partition and the surface layers (the A-surface and the B-surface).
US Pat. No. 10,478,439

USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK)

Pharmacyclics LLC, Sunny...

1. A method of inhibiting proliferation and survival of activated B-cells in a human subject suffering from a B-cell proliferative disorder, comprising: orally administering to the human subject suffering from a B-cell proliferative disorder a therapeutically effective amount of 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (Compound 13), on a continuous once-daily regimen until progression of the disorder or unacceptable toxicity,wherein said administration of the therapeutically effective amount results in an AUC(0-24) of >about 100 ng*h/ml; and
wherein said administration of the therapeutically effective amount results in >90% of the Btk active sites in the peripheral blood mononuclear cells of the human subject being occupied by Compound 13 twenty-four hours following said administration.
US Pat. No. 10,479,978

POSTNATAL ADHERENT CELLS AND PREPARATION METHOD THEREFOR

CHA BIOTECH CO., LTD., S...

1. A method of preparing enhanced postnatal adherent cells, the method comprising:obtaining an amniotic tissue from a detached placenta;
harvesting cell populations by adding an enzyme mixed solution to the amniotic tissue, wherein the enzyme mixed solution comprises collagenase at a concentration of 0.5 mg/ml to 5 mg/ml, trypsin at a concentration of 1 mg/ml to 5 mg/ml, DNA hydrolase (DNase) at a concentration of 0.01 mg/ml to 0.05 mg/ml, and dispase at a concentration of 0.1 U/ml to 5 U/ml;
isolating the enhanced postnatal adherent cells by culturing the harvested cell populations in a container by adhesion culture and then treating the cell populations with an animal component-free (ACF) recombinant enzyme; and
subculturing the isolated enhanced postnatal adherent cells under a hypoxia condition lower than a normoxia condition of 21% in a medium containing fibroblast growth factor-4 (FGF-4) and heparin at least 6 passages, wherein the subculturing further comprises treatment of the animal component-free recombinant enzyme before transferring the cells for subculturing at every stage of subculturing, and
wherein 80% or more of the adherent cells express CD44, CD73, CD90, and CD105-positive surface markers and 10% or less thereof express a CD45-negative surface marker, and more vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) are secreted compared to the isolated enhanced postnatal adherent cells of passages 1 to 4.
US Pat. No. 10,478,442

METHOD FOR THE TREATMENT OF DRAVET SYNDROME

THE KATHOLIEKE UNIVERSITE...

1. A method of adjunctive treatment of seizures in a patient diagnosed with Dravet syndrome, comprising:administering to the patient 0.2 mg/kg/day of fenfluramine or a pharmaceutically acceptable salt thereof; and
administering to the patient an effective dose of stiripentol or a pharmaceutically acceptable salt thereof to said patient;
whereby seizures are ameliorated in the patient.
US Pat. No. 10,479,980

ARTIFICIAL OVARY

NORTHWESTERN UNIVERSITY, ...

1. An artificial ovary comprising:a porous three-dimensional scaffold comprising a plurality of overlapping struts, the struts comprising a biocompatible polymer and defining a network of pores; and
a plurality of ovarian follicles disposed inside the pores;
wherein the artificial ovary is capable of supporting at least one of: an ovarian endocrine function; or ovulation of one or more mature oocytes from one or more of the ovarian follicles, when the artificial ovary is cultured in vitro or implanted in a mammalian subject in vivo,
provided that if the biocompatible polymer comprises ovarian extracellular matrix, then that ovarian extracellular matrix comprises processed decellularized ovarian extracellular matrix.
US Pat. No. 10,478,447

ANTIVIRAL SUPPLEMENT FORMULATIONS

Vymedic, LLC, Parker, CO...

1. A method of treating a viral infection in a subject in need thereof comprising administering to the subject a dosage form comprising a therapeutically effective amount of a composition comprising a lysine in a single dose range of from about 1,000 mg to about 5,000 mg, an ascorbic compound, a flavonoid glycoside, wherein the flavonoid glycoside comprises hesperidin and rutin, a threonine, a taurine and a pyridoxine, and wherein the viral infection is selected from the group consisting of an influenza virus infection and a non-polio enterovirus infection.
US Pat. No. 10,479,988

METHOD OF MAKING A VACCINE

LUMAGENICS, LLC, Nashvil...

1. A method of producing a live or dead attenuated infectious cells comprising:a) isolating a plurality of infectious cells;
b) selecting a high energy UV light source that delivers a low heat UV containing light to the end of a light guide;
c) selecting the UV light source and output so that UV energy from the light source can selectively attenuate cells; and
d) exposing the infectious cells to the light from the end of the light guide at sufficient distance and wherein the cells are exposed to the light from about 0.1 seconds to about 5 seconds to attenuate the cells without damaging cellular proteins and carbohydrates that produce the immune response to produce attenuated cells.
US Pat. No. 10,478,451

USE OF DEXTRAN SULFATE

TX MEDIC AB, Viken (SE)

1. A method of treating cardiac fibrosis in a subject, said method comprising systemically administering dextran sulfate, or a pharmaceutically acceptable salt thereof, to a subject suffering from or having a risk of suffering from cardiac fibrosis.
US Pat. No. 10,479,991

METHOD AND REAGENT FOR CONSTRUCTING NUCLEIC ACID DOUBLE-LINKER SINGLE-STRAND CYCLICAL LIBRARY

MGI TECH CO., LTD, Shenz...

1. A method for constructing a library of single-stranded cyclic nucleic acid fragments having double adaptors, comprising the following steps carried out in the following order:(1) disrupting a nucleic acid into nucleic acid fragments for library construction and selecting disrupted fragments using magnetic bead purification or gel recovery;
(2) subjecting the fragments to dephosphorylation and end repairing reactions;
(3) ligating a 5? adaptor A sequence to the fragments, wherein the 5? adaptor A sequence comprise a strand with 5? end phosphorylation modification and the other strand with 3? end dideoxy modification and uracil (U) base sites;
(4) performing a one-step reaction of Uracil-Specific Excision Reagent enzyme digestion and phosphorylation using Uracil-Specific Excision Reagent (USER) enzyme and T4 polynucleotide kinase;
(5) ligating a first 3? L-type adaptor sequence to the 5? end of each strand of the phosphorylated nucleic acid fragments;
(6) performing a first polymerase chain reaction (PCR) amplification to obtain first products having the first adaptor sequence at both ends, wherein the primer sequences used in the first PCR have a U base site and have a nickase recognition sequence, and one of the primers has a biotin label; followed by purification using magnetic beads;
(7) digesting the first products with a Uracil-Specific Excision Reagent (USER) enzyme to remove the U base site in the primer sequences to generate sticky ends and generate or do not generate a gap;
(8) performing a double-stranded cyclization of the digested first products to generate cyclic nucleic acid molecules, which having a nickase recognition sequence on one strand and a gap on the other strand or having a nickase recognition sequence but not a gap on both strands, such that cyclization occurs due to the complementarity of the sticky ends to generate cyclized nucleic acid molecules;
(9) performing linear digestion by treating the cyclic nucleic acid molecules having a nickase recognition sequence on one strand and a gap on the other strand or having a nickase recognition sequence but not a gap on both strands with a nickase to generate a nick;
(10) performing magnetic purification by binding the treated cyclic nucleic acid molecules to streptavidin magnetic beads via the biotin label on the cyclic nucleic acid molecules; and allowing a solid phase carrier harboring a second affinity label to bind to the cyclic nucleic acid molecules;
(11) enzymatically digesting the nickase recognition sequence with nickase to get a nick on each single-strand to provide an initiation site for controlled nick translation (CNT), wherein the enzymatic reaction proceeds on the magnetic beads without eluting the nucleic acids from the magnetic beads;
(12) initiating a controlled nick translation reaction from the nick and/or gap by using the cyclic nucleic acid molecules bound to the streptavidin magnetic beads, wherein in the controlled gap translation reaction, the length of the gap translation fragments generated is controlled by controlling at least one factor selected from the group consisting of the molar ratio of deoxynucleotide triphosphates (dNTPs) to the nucleic acid molecules as template, the enzymatic reaction temperature, and the enzymatic reaction time, to generate nucleic acid fragments with a length in the range of 50-250 base pairs (bp);
(13) digesting and removing the portion of the respective cyclic nucleic acid molecules that does not undergo the controlled gap translation reaction to obtain linear nucleic acid molecules;
(14) ligating a second adaptor sequence bubble-type adaptor comprising a top strand and a bottom strand which are complementary to one another to both ends of the linear nucleic acid molecules, wherein the bottom strand having U base sites;
(15) performing Uracil-Specific Excision Reagent (USER) enzyme digestion of the U base site;
(16) performing a second polymerase chain reaction amplification to obtain second products having the second adaptor sequence at both ends;
(17) denaturing the second products to obtain single-stranded nucleic acid molecules, and cyclizing one of the single-stranded nucleic acid molecules with a mediating sequence complementary to both ends of the single-stranded nucleic acid molecule to obtain the library of single-stranded cyclic nucleic acid fragments having double adaptors to produce nucleic acid fragments in a size range of 50 bp to 250 bp, and wherein the steps of the method provide fragments suitable for next-generation sequencing on a Complete Genomics sequencing platform.
US Pat. No. 10,479,993

MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) EXPRESSION

Ionis Pharmaceuticals, In...

1. A compound comprising a sodium salt of a single-stranded modified oligonucleotide consisting of 16 linked nucleosides having a nucleobase sequence consisting of SEQ ID NO: 245, and comprises:a gap segment consisting of ten linked deoxynucleosides;
a 5? wing segment consisting of 3 linked nucleosides; and
a 3? wing segment consisting of 3 linked nucleosides;
wherein the gap segment is positioned between the 5? wing segment and the 3? wing segment; wherein each nucleoside of each wing segment comprises a constrained ethyl nucleoside; wherein each internucleoside linkage of the modified oligonucleotide is a phosphorothioate linkage; and wherein each cytosine of the modified oligonucleotide is a 5-methylcytosine.
US Pat. No. 10,478,462

ALCOHOL METABOLISM PROMOTER

NICHIREI BIOSCIENCES INC....

1. A method for suppressing an increase in a blood acetaldehyde level, comprising:causing a subject in need thereof to ingest an extract of a Veneroida bivalve in an effective amount, wherein an amount of glycogen in the extract is 50% to 90% by mass.
US Pat. No. 10,480,000

METHODS OF INCREASING CROP YIELD UNDER ABIOTIC STRESS

CERES, INC., Thousand Oa...

1. A method of increasing plant yield in a plant grown under drought stress, osmotic stress, or nitrogen deficiency, said method comprising:(a) growing plants transformed with an exogenous nucleic acid under drought stress, osmotic stress, or nitrogen deficiency, said exogenous nucleic acid comprising a heterologous promoter operably linked to a nucleotide sequence encoding a polypeptide having at least 95% amino acid sequence identity to the amino acid sequence as set forth in SEQ ID NO: 2; and
(b) selecting a transformed plant from said transformed plants that expresses said polypeptide and has increased yield when grown under drought stress, osmotic stress, or nitrogen deficiency as compared to the corresponding yield of a control plant of the same species that does not comprise said exogenous nucleic acid and grown under identical stress conditions.
US Pat. No. 10,478,465

HERBAL COMPOSITION FOR THE TREATMENT AND MANAGEMENT OF CANCER AND METHOD OF PREPARATION THEREOF

Muniyal Ayurvedic Researc...

1. An oral composition comprising Vinca rosea, Aristolochia indica, Eclipta alba, Moringa oleifera, Curcuma longa and a therapeutically effective amount of Kajjali; wherein said composition is in a form selected from a group consisting of tablets, pellets, lozenges, granules, suspensions and capsules.
US Pat. No. 10,480,003

CONSTRUCTS AND SYSTEMS AND METHODS FOR ENGINEERING A CO2 FIXING PHOTORESPIRATORY BY-PASS PATHWAY

THE REGENTS OF THE UNIVER...

1. A recombinant host cell comprising heterologously expressed genes mcr, mcl, mch, mct, meh, and pcs, and a second heterologously expressed mct gene, and wherein the recombinant host cell does not naturally express the heterologously expressed genes and wherein the host cell produces a synthetic photorespiratory bypass pathway.
US Pat. No. 10,478,466

TOPICAL VASODILATOR COMPOSITION

1. A topical composition comprising:(a) from about 0.05% to about 10.0% by weight of Arnica oil;
(b) from about 5.0% to about 20.0% by weight of a notoginseng herb comprising dammarane-type ginseno sides;
(c) from about 0.05% to about 10% by weight of a compound comprising cyclopentasiloxane, dimethicone crosspolymer, dimethicone/vinyl dimethicone crosspolymer, and dimethiconol;
(d) from about 0.05% to about 5.0% by weight cetearyl alcohol;
(e) from about 0.75% to about 0.85% by weight of a compound formed from diazolidinyl urea (“DU”) and iodopropynyl butylcarbamate (“IPBC”), wherein the ratio of DU to IPBC is substantially 99% to 1% by weight;
(f) about 0.05% to about 2.5% by weight of dimethyl sulfone;
(g) about 0.25% weight of phytonadione; and
a cosmetically acceptable aqueous carrier, wherein upon a topical application of the composition to a skin contusion region, such application promotes vasodilatation in the region and dissipation of the contusion, wherein the notoginseng herb comprising dammarane-type ginsenosides is selected from the group consisting of, Panax quinquefolius, Panax vietnamensis, and Panax notoginseng and mixtures thereof.
US Pat. No. 10,478,467

METHODS AND COMPOSITIONS ADDRESSING DEPRESSED MOOD

Centre for Addiction and ...

1. A method for treatment or prophylaxis of depressed mood in a subject experiencing excessive crying at up to 18-months postpartum, comprising administering to a subject in need thereof:an antioxidant source once daily on at least day-1 of a treatment regime of from 3 to 5 days; wherein the antioxidant source comprises an anthocyanin-containing fruit, vegetable, nut, legume, or a juice or extract thereof, and has an ORAC value of at least about 3000 ?mol TE/serving;
a tryptophan composition on the evening of the penultimate day of the treatment regime, simultaneously or following the antioxidant source, said tryptophan composition comprising from 1.0 g to 5.0 g of L-tryptophan per serving in free amino acid form, and acceptable diluents; and
a tyrosine composition on the final day of the treatment regime, said tyrosine composition comprising from 2.0 g to 50 g of L-tyrosine per serving in free amino acid form, and acceptable diluents.
US Pat. No. 10,480,005

SOYBEAN VARIETY 5PEKB42

MONSANTO TECHNOLOGY LLC, ...

1. A plant of soybean variety 5PEKB42, wherein a sample of seed of said variety has been deposited under ATCC Accession No. PTA-126130.
US Pat. No. 10,478,469

WEEKLY DOSING REGIMENS FOR ANTI-CD30 VC-PAB-MMAE ANTIBODY DRUG-CONJUGATES

SEATTLE GENETICS, INC., ...

1. A method for treating a CD30-expressing hematologic cancer in a human subject, the method comprising administering to a subject in need thereof a dose of a pharmaceutical composition comprising cAC10-MC-vc-PAB-MMAE antibody-drug conjugate, wherein the administered dose of cAC10-MC-vc-PAB-MMAE antibody-drug conjugate is 1.8 mg/kg of the subject's body weight and the pharmaceutical composition is administered every three weeks as a monotherapy, wherein the pharmaceutical composition is administered for two or more 21-day treatment cycles.
US Pat. No. 10,478,470

PHARMACEUTICAL COMPOSITION CONTAINING LEUPROLIDE AND HAVING BOTH IMMEDIATE AND SUSTAINED RELEASE PROPERTIES

SK CHEMICALS CO., LTD., ...

1. A method for preparing a pharmaceutical composition, the method comprising the steps of:(a) preparing an immediate release part comprising leuprolide as a first active ingredient;
(b) preparing a sustained release part comprising leuprolide contained in a microsphere as a second active ingredient, wherein the microsphere is prepared by the steps of:
(i) mixing an inner aqueous phase (W1) containing leuprolide, a thickener and an aqueous solvent with an oil phase (O) containing a polymer and a fat-soluble solvent to obtain a W1/O emulsion;
(ii) dispersing the W1/O emulsion of step (i) in a polyvinyl alcohol aqueous solution (W2) to obtain a W1/O/W2 emulsion; and
(iii) drying and recovering the W1/O/W2 emulsion prepared in step (ii); and
(c) mixing the immediate release part and the sustained release part in a pharmaceutically acceptable carrier to form a pharmaceutical composition, wherein the immediate release part comprises 0.1% to 20% of a total amount of leuprolide in the pharmaceutical composition and wherein the microsphere of the sustained release part comprises 80% to 99.9% of the total amount of leuprolide in the pharmaceutical composition; and wherein the ratio of leuprolide in the immediate release part to leuprolide in the microsphere of the sustained release part is determined to achieve both immediate and sustained release properties.
US Pat. No. 10,480,009

BIOLOGICAL STATE MACHINES

Massachusetts Institute o...

1. A system, comprising:(a) n serine recombinases, wherein n is greater than 2; and
(b) an engineered nucleic acid comprising n(n?1) pairs of cognate recombination recognition sites (RRS),wherein the n(n?1) pairs of RRSs of (b) are arranged in an overlapping configuration such that the two RRSs of each pair of the n(n?1) pairs of RRSs are separated from each other by at least one RRS of another pair of the n(n?1) pairs of RRSs, and wherein recombination between the two RRSs of each pair of the n(n?1) pairs of RRSs either inverts or excises at least one RRS of another pair of the n(n?1) pairs of RRSs.
US Pat. No. 10,478,472

COMBINATION OF TOLEROGENIC PEPTIDES AND TFG-B FOR USE IN THE INDUCTION AND MAINTENANCE OF ORAL TOLERANCE IN YOUNG MAMMALS

Societe des Produits Nest...

1. A method for induction and maintenance of oral tolerance to ?-lactoglobulin (BLG) and maintenance of oral tolerance to other food proteins that has been acquired via consumption of maternal mill in a young mammal during and after weaning period, the method comprising administering to the young mammal a composition comprising at least eight different peptides; each having a length from five to twelve amino adds that comprises a sequence selected from SEQ ID No. 1-8, and the composition further comprising transforming growth factor-beta (TGF-?), wherein each of SEQ ID NOs: 1-8 is present in the composition.
US Pat. No. 10,480,010

BACULOVIRUS EXPRESSION SYSTEMS

GENETHON, Evry (FR)

1. A method for producing a recombinant adeno-associated virus (rAAV) vector, comprising infecting a cell with one or several recombinant baculovirus(es), each baculovirus comprising a recombinant baculovirus genome harboring a heterologous sequence;wherein the heterologous sequence from each of the one or several recombinant baculovirus(es) encodes a different part of said rAAV vector; and
wherein each of the one or several recombinant baculovirus(es) comprises a recombinant baculovirus genome comprising the p26 and p74 baculoviral genes, and wherein the baculoviral genes cathepsin, chitinase and p10 are disrupted in each of the one or several recombinant baculovirus(es).
US Pat. No. 10,480,780

METHOD AND APPARATUS FOR COMMISSIONING POWER PLANTS

Boyle Energy Services and...

1. A process for commissioning steam flushing of steam generation equipment and piping, of a steam power plant, to make it operational for steady state operation, the steam power plant including a boiler generating steam, turbine and condenser components, and interconnecting piping to form a power cycle steam power plant as a closed steam circuit, the process comprising,Wherein during the commissioning, bypassing the turbine component by diverting steam through a bypass pipe, wherein said steam is thereby flushed through at least portions of the steam circuit to cleanse one or more of piping portions and equipment components, wherein the diverted flushing steam is drawn from the plant boiler through a temporary pipe and routed to the condenser component and a portion of condensate liquid is drawn from the condenser component and is injected as droplets into the steam flow at multiple piping locations upstream of the condenser component for removing particulate and non-particulate contamination from the flush steam prior to the entry of said flush steam to the condenser component; testing the flush steam for the presence of both particulate and non-particulate contamination prior to the entry of said diverted flushing steam to the condenser component; and terminating the entry of said diverted flush steam to the condenser component to prevent damage to the condenser component by the entry of said steam to the condenser component, and wherein the injected liquid comprises basic chemicals added thereto prior to injection to chemically treat the flushing steam and piping surface to enhance removal of contamination from the steam circuit.
US Pat. No. 10,479,756

DIESTERS FOR PERSONAL CARE APPLICATIONS DERIVED FROM 1-METHYLHEPTYL ALCOHOL

Inolex Investment Corpora...

1. A diester exhibiting improved hydrolytic stability that is an esterification product of a 1-methylheptyl alcohol and a dicarboxylic acid.
US Pat. No. 10,479,758

HAFNIUM-BASED METAL-ORGANIC FRAMEWORKS AS EPOXIDE RING-OPENING CATALYSTS

NORTHWESTERN UNIVERSITY, ...

1. A metal-organic framework comprising:inorganic nodes that comprise an octahedral Hf6 cluster capped by eight ?3-ligands and having twelve octahedral edges, wherein the ?3-ligands are hydroxo ligands, oxo ligands or aquo ligands; and
organic linkers connecting the organic nodes, the organic linkers comprising 1,3,6,8-tetrakis(p-benzoic acid)pyrene units; wherein eight of the twelve octahedral edges of the inorganic nodes are connected to the 1,3,6,8-tetrakis(p-benzoic acid)pyrene units.
US Pat. No. 10,480,015

METABOLIC ENGINEERING FOR MICROBIAL PRODUCTION OF TERPENOID PRODUCTS

MANUS BIO INC., Cambridg...

1. A method for production of a terpene or terpenoid product, comprising:providing an E. coli bacterial strain that produces isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) through an upstream methylerythritol phosphate pathway (MEP pathway) and converts the IPP and DMAPP to a terpene or terpenoid product through a recombinant downstream synthesis pathway;
wherein IspG and IspH enzymes are overexpressed in the bacterial strain by complementation with recombinant ispG and ispH genes, such that IspH activity is higher than IspG activity to provide increased carbon flux to 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) intermediate, while preventing accumulation of HMBPP at an amount that feeds back and reduces MEP pathway flux and terpene or terpenoid productivity; the strain comprising a recombinant pyruvate:flavodoxin oxidoreductase (PFOR) enhancing supply and/or transfer of electrons through the MEP pathway and/or to terpene and terpenoid products, and culturing the bacterial strain to produce the terpene or terpenoid product.
US Pat. No. 10,478,478

TREATMENT OF RAYNAUD'S PHENOMENON USING BOTULINUM TOXIN TYPE B

NATIONAL UNIVERSITY CORPO...

1. A method of treating Raynaud's phenomenon, comprising administering a therapeutically effective amount of botulinum toxin type B to a subject in need thereof, wherein said botulinum toxin type B is injected to sites between fingers and at the external sides of metacarpophalangeal joints of the first and fifth fingers of the subject.
US Pat. No. 10,478,479

METHOD FOR PREPARING DENDRITIC CELL, DENDRITIC CELL PREPARED THEREBY, AND USE THEREOF

JW CREAGENE INC., Gyeong...

1. A method for preparing a dendritic cell, comprising:culturing an immature dendritic cell to a mature dendritic cell with treating by 1-10 ng/mL of rapamycin and a maturation factor; and
after maturation of the immature dendritic cell to the mature dendritic cell has been completed, sensitizing the mature dendritic cell with an antigen bound to a peptide having cell permeability,
wherein said sensitizing of the mature dendritic cell with the antigen bound to the peptide having cell permeability is performed at least 6 hours and up to 48 hours after said treating by the maturation factor, and
wherein said sensitizing of the mature dendritic cell with the antigen bound to the peptide having cell permeability is performed for 1 to 8 hours.
US Pat. No. 10,480,017

PROCESS FOR USING BIOGENIC CARBON DIOXIDE DERIVED FROM NON-FOSSIL ORGANIC MATERIAL

Iogen Corporation, Ottaw...

1. A process for producing a fuel or fuel intermediate containing carbon derived from non-fossil organic material comprising:(i) providing biogenic carbon dioxide that is sourced from a production process comprising at least one of a step of fermentation and a thermal process, said production process producing a first product derived from the non-fossil organic material, said first product selected from: (a) an energy product; (b) a biogenic carbon-based product selected from a chemical product, a fuel and a fuel intermediate; and (c) a combination thereof, wherein the biogenic carbon dioxide is generated during the production process;
(ii) providing a stream enriched in hydrogen that is sourced from a hydrogen production process, the hydrogen production process including a step of removing fossil carbon dioxide from a stream including hydrogen to provide the steam enriched in hydrogen;
(iii) converting the biogenic carbon dioxide and hydrogen from the enriched hydrogen stream to a second product, said second product comprising at least one of a biogenic carbon-based fuel and a biogenic carbon-based fuel intermediate; and
(iv) carrying out or arranging for one or more parties to carry out at least one step that contributes to a reduction in the life cycle greenhouse gas (GHG) emissions of the second product.
US Pat. No. 10,481,301

NANOMETRIC TIN-CONTAINING METAL OXIDE PARTICLE AND DISPERSION, AND PREPARATION METHOD AND APPLICATION THEREOF

Xiamen Nanotech Co Ltd, ...

1. A method for preparing a dispersion of tin-containing metal oxide nano-particles, wherein the tin-containing metal oxide comprises tin element and an aid metallic element other than tin selected from antimony, indium, titanium, copper, zinc, zirconium, cerium, yttrium, lanthanum, niobium or a mixture thereof; and the tin-containing metal oxide nano-particles have an initial average particle diameter of 2-50 nm, a particle diameter distribution as defined with an Index of dispersion degree of less than 7 and a steepness ratio of less than 3, the method comprises steps of:(1) reacting a solution containing tin ions and a solution containing ions of the aid metallic element other tin with a solution of precipitating agent at a temperature of less than 100° C. under a non-acidic condition in an aqueous medium comprising at least one of alcohols, amides, ketones, epoxides and mixtures thereof to form tin-containing metal oxide precursor particles and a first by-product in ionic form; wherein the precipitating agent is selected from alkali metal hydroxides, alkaline earth metal hydroxides, alkali metal carbonates, alkaline earth metal carbonates, alkali metal bicarbonates, ammonia, organic bases and mixtures thereof;
(2) separating the tin-containing metal oxide precursor particles from the first by-product in ionic form to obtain tin-containing metal oxide precursor particles substantially free of ionic impurities;
(3) reacting the tin-containing metal oxide precursor particles substantially free of Ionic impurities with an oxidizing agent or a reducing agent at a temperature of 150-400° C. and a pressure of 5 to 10 atmospheres to obtain tin-containing metal oxide particles and a second by-product in ionic form;
(4) coating the tin-containing metal oxide particles with a surfactant in an amount of 0.01% to 30% relative to the weight of tin-containing metal oxide particle to obtain coated tin-containing metal oxide particles, wherein the surfactant is selected from a non-silane surface modifying agent, a silane coupling agent, a titanate coupling agent, or a mixture thereof, and the non-silane surface modifying agent is selected from cationic surfactants, non-ionic surfactants, polymeric surfactants and mixtures thereof;
(5) separating the coated tin-containing metal oxide particles from the second by-product in ionic form to obtain tin-containing metal oxide nano-particles substantially free of ionic impurities;
(6) adding a dispersion medium and a dispersing agent to the tin-containing metal oxide nano-particles substantially free of Ionic impurities to obtain the dispersion of tin-containing metal oxide nano-particles,
wherein, when the dispersion medium is water in step (6), the dispersing agent is one or more selected from ethanolamine, triethanolamine, triethylamine, diisopropanol amine, tetramethylammonium hydroxide, polyvinyl alcohol, methacryloxy silane, polyacrylic acid ammonium salt dispersing agent, polyacrylic acid sodium salt dispersing agent, polysiloxane dispersing agent, polyamide dispersing agent, polymer block copolymer dispersing agent; and when the disperse medium is an organic solvent the dispersing agent is one or more selected from octylamine, polycarboxylic salt dispersing agents, polycarboxylic-sulfonic copolymer dispersing agents, polymaleicanhydride copolymer dispersing agents, silane coupling agents, titanate coupling agents.
US Pat. No. 10,478,480

PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST PROSTATE CANCER AND OTHER CANCERS

IMMATICS BIOTECHNOLOGIES ...

1. A method of eliciting an immune response in a patient who has cancer, comprising administering to said patient a population of activated T cells that kill cancer cells that present a peptide consisting of the amino acid sequence of GYLQGLVSF (SEQ ID NO: 27),wherein said cancer is selected from liver cancer, benign prostate hyperplasia, and prostate cancer.
US Pat. No. 10,480,018

GENUS OF EPIMERASE ENZYMES FOR CONVERSION OF FRUCTOSE TO ALLULOSE AT HIGH TEMPERATURE AND LOW PH

ARCHER DANIELS MIDLAND CO...

1. A method of producing allulose comprising:contacting a solution containing fructose with an enzyme having epimerase activity, the enzyme having a sequence selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 18, SEQ ID NO: 16, and SEQ ID NO: 14 for a time and under conditions suitable to convert at least a portion of the fructose to allulose;
wherein when placed in contact with fructose at a temperature of 50° C. for 2 hours at a pH of 6, the enzyme converts the fructose to the allulose.
US Pat. No. 10,478,481

PEPTIDES AND COMBINATION OF PEPTIDES AND SCAFFOLDS FOR USE IN IMMUNOTHERAPY AGAINST RENAL CELL CARCINOMA (RCC) AND OTHER CANCERS

IMMATICS BIOTECHNOLOGIES ...

1. A method of eliciting an immune response in a patient who has cancer, comprising administering to said patient a population of activated T cells that selectively recognize cells that aberrantly express a peptide consisting of the amino acid sequence selected from SEQ ID NOs: 58-60, 93, and 96;wherein said cancer is selected from the group consisting of kidney cancer (RCC), lung cancer, brain cancer, stomach cancer, colon or rectal cancer, liver cancer, pancreatic cancer, prostate cancer, leukemias, breast cancer, melanoma, ovarian cancer, and esophageal cancer.
US Pat. No. 10,480,021

METHODS FOR CLOSED CHROMATIN MAPPING AND DNA METHYLATION ANALYSIS FOR SINGLE CELLS

YALE UNIVERSITY, New Hav...

1. A method of identifying regions of methylated genomic DNA in a double stranded genomic DNA sample, the method comprising sequentially:(a) digesting a double stranded genomic DNA sample with one or more methylation sensitive restriction endonucleases (MSREs), thereby forming digested, unligated DNA fragments;
(b) amplifying the digested, unligated DNA fragments by multiple displacement amplification (MDA), thereby producing a plurality of heterogeneous amplicons, the MDA comprising denaturing the digested, unligated DNA fragments and forming single stranded DNA fragments, annealing random primers to the single stranded DNA fragments, and extending the primers annealed to the single stranded DNA fragments with a polymerase;
(c) sequencing the amplicons; and
(d) identifying the regions of methylated genomic DNA in the double stranded genomic DNA sample based on the sequences of the amplicons.
US Pat. No. 10,480,278

CEMENT SPACER FLUID COMPRISING QUATERNARY SURFACTANT, VISCOSIFIER, AND PROPPANT

BAKER HUGHES, A GE COMPAN...

1. A method of cementing a wellbore penetrating a subterranean formation, the method comprising:injecting into the wellbore a cement spacer fluid comprising a carrier fluid, a quaternary surfactant, a viscosifier, and a proppant;
injecting a cement slurry into the wellbore; and
allowing the cement slurry to set,
wherein the carrier fluid comprises water;
the proppant comprises ceramic particles, sand, a nut shell, gravel, glass, or a combination comprising at least one of the foregoing;
the quaternary surfactant has a cation of R1 R2 R3 R4N+ and an anion, wherein R1, R2, R3 and R4 are each independently a straight or branched C1-30 alkyl group, a C7-30 alkylbenzyl group, a C7-30 arylalkyl group, a straight or branched C3-30 alkenyl group, a C1-30 hydroxyalkyl group, a C7-30 hydroxyalkylbenzyl group, or a polyoxyalkylene group; and the anion comprises a halide, a perchlorate, a thiocyanate, a cyanate, a carboxylate, an alkyl sulfate, an alkyl sulfonate, PF6?, AsF6?, SbF6?, NO2?, NO3?, SO4?, or BX4?, wherein X is a halide;
the viscosifier comprises guar gums, guar derivatives, hydratable polysaccharides, xanthan gum, galactomannan gums, glucomannan gums, cellulose, cellulose derivatives, poly((meth)acrylic acid)s, poly((meth)acrylamides), copolymers of (meth)acrylic acid and (meth)acrylamide, C1-8 alkyl poly(meth)acrylates, clays, or a combination comprising at least one of the foregoing viscosifiers; and
the cement spacer fluid comprises about 30 to about 100 wt % of the carrier fluid, about 0.05 to about 10 wt % of the quaternary surfactant, about 0.05 to about 10 wt % of the viscosifier, and about 1 to about 65 wt % of the proppant, each based on the weight of water in the cement spacer fluid.
US Pat. No. 10,478,484

GNA1870-BASED VESICLE VACCINES FOR BROAD SPECTRUM PROTECTION AGAINST DISEASES CAUSED BY NEISSERIA MENINGITIDIS

1. A composition comprising:isolated antigenic vesicles prepared from a Neisseria meningitidis (N. meningitidis) genetically modified to disrupt production of the endogenous GNA1870 polypeptide so that the endogenous GNA1870 is not present at detectable levels in the isolated antigenic vesicles and to overexpress at least one full length meningococcal GNA1870 polypeptide at a level sufficient to provide for production of the isolated antigenic vesicles that, when administered to a mammalian subject elicit anti-meningococcal GNA1870 polypeptide antibodies,
wherein the overexpressed GNA1870 polypeptide is a meningococcal variant 1, a variant 2 GNA1870 polypeptide, or a variant 3 GNA1870 polypeptide heterologous to the N. meningitidis,
wherein the isolated antigenic vesicles are outer membrane vesicles (OMVs), microvesicles (MVs), or a mixture of the OMVs and the MVs, and
wherein the N. meningitidis is genetically modified to provide for decreased toxic activity of its lipid A relative to its parental unmodified N. meningitidis; and
a pharmaceutically acceptable carrier.
US Pat. No. 10,480,022

SPATIALLY ENCODED BIOLOGICAL ASSAYS

Prognosys Biosciences, In...

1. A method for determining a spatial location of a biological molecule of a tissue sample comprising(a) providing a plurality of beads, wherein the plurality of beads comprise a plurality of binding agents, wherein a binding agent of the plurality of binding agents (i) comprises a coding identifier having a nucleic acid sequence and (ii) is configured to interact with a biological molecule of a tissue sample, wherein the coding identifier corresponds to a location at which the binding agent interacts with a biological molecule of a tissue sample;
(b) contacting the plurality of beads with the tissue sample such that the binding agent interacts with the biological molecule; and
(c) using the coding identifier to identify the location where the binding agent interacted with the biological molecule, thereby determining a spatial location of the biological molecule of the tissue sample.
US Pat. No. 10,480,023

METHOD FOR BLOCKING MIRNA

HudsonAlpha Institute for...

1. A method of preventing an unwanted micro-RNA (miRNA) that is one of a plurality of miRNAs from participating in reverse transcription polymerase chain reactions (RT-PCR), the unwanted miRNA having a 5? end and a 3? end, the method comprising:(a) annealing a complementary region of a blocking nucleic acid to a binding region at a first end of the unwanted miRNA, wherein the first end of the unwanted miRNA is one of the 5? end or the 3? end; and wherein the blocking nucleic acid comprises:
(i) a Crick strand having a 3? end and a 5? end;
(ii) a single stranded complementary region at one of the 5? end of the Crick strand or the 3? end of the Crick strand, that anneals with the binding region under stringent conditions;
(iii) a double-stranded region on the Crick strand adjacent to the complementary region, the double-stranded region comprising a Watson strand that is annealed to the Crick strand, the Watson strand having a 5? end and a 3? end;
(iv) a first blocking moiety linked to the 3? end of the Crick strand, wherein the first blocking moiety cannot serve as a substrate for ligases;
(v) a second blocking moiety linked to the 5? end of the Crick strand, wherein the second blocking moiety cannot serve as a substrate for ligases;
(vi) a third blocking moiety linked to the 3? end of the Watson strand if the complementary region is at the 3? end of the Crick strand, or linked to the 5? end of the Watson strand if the complementary region is at the 5? end of the Crick strand, wherein the third blocking moiety cannot serve as a substrate for ligases; and
(vii) a ligative terminal end on the Watson strand, the ligative terminal end located at the 3? end of the Watson strand if the complementary region is at the 5? end of the Crick strand, or at the 5? end of the Watson strand if the complementary region is at the 3? end of the Crick strand;
(b) ligating an adenylated nucleic acid adapter to the plurality of miRNAs before or after step (a); and
(c) performing RT-PCR on the plurality of miRNAs.
US Pat. No. 10,480,024

SINGLE NUCLEOTIDE DETECTION METHOD

BASE4 INNOVATION LTD, Ca...

1. A method for determining the sequence of nucleotide bases in a polynucleotide analyte, the method comprising steps of:(1) generating a stream of single nucleotide bases from the polynucleotide analyte, wherein the stream of single nucleotide bases is obtained by progressive pyrophosphorolysis of the polynucleotide analyte;
(2) producing captured molecules by reacting each single nucleotide base with a capture system, wherein the capture system comprises different sets of capture molecules, each set being selective for a different nucleotide base;
(3) for each captured molecule, amplifying at least part of the captured molecule to produce a plurality of amplicons;
(4) for each captured molecule, labelling the amplicons with a corresponding probe selective for the amplicons and comprising a different detectable element, wherein the probes are present in a mixture of probes each selective for a different nucleotide base;
(5) for each captured molecule, detecting a property characteristic of the detectable element; and
(6) from the totality of the results of step (5), determining the sequence of nucleotide bases in the polynucleotide analyte.
US Pat. No. 10,480,028

METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES

10X GENOMICS, INC., Plea...

1. A method for analyzing cells comprising:(a) contacting a plurality of cells with an antibody to provide a cell bound to said antibody, wherein said antibody is attached to a reporter oligonucleotide comprising a reporter sequence;
(b) co-partitioning at least a subset of said plurality of cells into a plurality of wells, wherein a well of said plurality of wells comprises (i) said cell bound to said antibody and (ii) a first nucleic acid molecule comprising a barcode sequence; and
(c) using said reporter oligonucleotide and said first nucleic acid molecule to generate a second nucleic acid molecule comprising (i) said reporter sequence, and (ii) said barcode sequence.
US Pat. No. 10,479,773

LIGNIN-BASED SOLVENTS AND METHODS FOR THEIR PREPARATION

SHELL OIL COMPANY, Houst...

1. A process for converting biomass into furfural, the process comprising the steps of:(a) providing a pentosan-containing biomass material;
(b) subjecting the pentosan-containing biomass material to an acid catalyzed digestion process in a digestion vessel at a temperature greater than about 100° C. for a period of time sufficient to produce a digested product stream comprising C5-carbohydrates and solids comprising cellulose;
(c) separating the digested product stream into a liquid product stream and a solid product stream wherein:
(i) the liquid product stream comprises carbohydrate compounds, of which at least 50 wt % of the carbohydrate compounds are C5-carbohydrate compounds, based on the weight of carbohydrate compounds in the liquid product stream,
(ii) the solid product stream comprises solids comprising lignin and cellulose;
(d) contacting the solid product stream with an organic solvent, thereby converting at least part of the lignin to a phenolic solvent, to produce solids and a solvent product stream comprising the phenolic solvent;
(e) subjecting the C5-carbohydrate in the liquid product stream to a dehydration reaction in a reaction vessel at a temperature in the range of from about 100° C. to about 250° C. in the presence of an acid catalyst and a biphasic mixture comprising an aqueous phase and a water-immiscible organic phase, which comprises at least a portion of the phenolic solvent produced in step (d), for a period of time sufficient to produce furfural or a furan derivative;
(f) retrieving from the reaction vessel a dehydration product stream comprising water, organic solvent and furfural, and separating the dehydration product stream into an aqueous recycle stream and an organic product stream comprising furfural;
(g) recovering the furfural from the organic product stream by at least one separation process; and
(h) recycling the organic product stream from step (g) back to the reaction vessel in step (e).
US Pat. No. 10,480,029

METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES

10X GENOMICS, INC., Plea...

1. A method for multi-analyte processing or analysis, comprising:(a) providing a mixture comprising a first analyte, a second analyte, a labelling agent comprising a reporter oligonucleotide molecule that comprises a reporter barcode sequence associated with said labelling agent, and a support having coupled thereto
(i) a first barcode molecule comprising a first oligonucleotide sequence configured to couple to said reporter oligonucleotide molecule, and
(ii) a second barcode molecule comprising a second oligonucleotide sequence configured to couple to said second analyte,
 wherein said second analyte is a different type of analyte than said first analyte,
 wherein said first oligonucleotide sequence is different from said second oligonucleotide sequence, and
 wherein said labelling agent is configured to couple to said first analyte;
(b) in said mixture, (i) using said reporter oligonucleotide molecule and said first oligonucleotide sequence of said first barcode molecule to synthesize a first barcoded product, and (ii) using said second analyte and said second oligonucleotide sequence of said second barcode molecule to synthesize a second barcoded product; and
(c) determining a sequence of (i) said first barcoded product or derivative thereof and (ii) said second barcoded product or derivative thereof, to identify said first analyte and/or said second analyte.
US Pat. No. 10,480,287

EPOXY-BASED SUBSEA INSULATION MATERIAL

Carboline Company, St. L...

3. The epoxy-based insulation material of claim 2, wherein the curing agent is a polyamine.
US Pat. No. 10,478,496

MONOCLONAL ANTIBODIES TO HUMAN FIBROBLAST GROWTH FACTOR RECEPTOR 2 (HFGFR2) AND METHODS OF USE THEREOF

DAIICHI SANKYO COMPANY, L...

1. A monoclonal antibody or an antigen binding fragment thereof,wherein the monoclonal antibody consists of
a heavy chain comprising a complimentary determining region H1 (CDRH1) consisting of the amino acid sequence represented by SEQ ID NO: 30, a CDRH2 consisting of the amino acid sequence represented by SEQ ID NO: 31, and a CDRH3 consisting of the amino acid sequence represented by SEQ ID NO: 32; and
a light chain comprising a CDRL1 consisting of the amino acid sequence represented by SEQ ID NO: 33, a CDRL2 consisting of the amino acid sequence represented by SEQ ID NO: 34, and a CDRL3 consisting of the amino acid sequence represented by SEQ ID NO: 35.
US Pat. No. 10,480,034

CANCER BIOMARKER AND DIAGNOSTIC

1. A method for the diagnosis and/or prognosis of colorectal cancer, in a subject, wherein the method comprises:(i) measuring the level of ATP11B gene expression and/or the quantity protein or peptides resulting from ATP11B gene translation in a biological sample from the subject, and
(ii) comparing the level or quantity measured in (i) with a reference value of the level of gene expression or quantity of proteins or peptides resulting from ATP11B gene translation, wherein the reference value represents a constitutive level of the gene expression and/or translation;wherein either:a) gene expression level or protein/peptide quantity at least about 40% (about 1.4-fold or more) above the reference value is indicative of a solid colorectal tumor, or
b) a gene transcription measurement or protein/peptide quantity substantially at or similar to the reference value indicates that no colorectal cancer tumor is present, and
(iii) treating the subject identified in (ii)(a) as having a solid colorectal tumor by administering radiotherapy or chemotherapy or carrying out surgery, or a combination thereof.
US Pat. No. 10,480,035

MULTIPLEX DIAGNOSTIC ASSAYS FOR LYME DISEASE AND OTHER TICK-BORNE DISEASES

Rutgers, the State Univer...

1. A kit for diagnosing a tick-borne disease, the kit comprising at least two of the following:a. a pair of Borrelia primers for a recA gene sequence of Lyme disease-causing Borrelia, having the respective sequences of SEQ ID Nos: 12 and 13; and a Borrelia-specific molecular beacon probe capable of distinguishing among B. burgdorferi, B. afzelii, and B. garinii having the sequence of SEQ ID No: 5;
b. a pair of Babesia primers for a conserved B. microti thiamine pyrophosphokinase (BmTPK) gene sequence having the respective sequences of SEQ ID Nos: 14 and 15 or of SEQ ID Nos: 24 and 25 and a Babesia-specific molecular beacon probe having the sequence of SEQ ID No: 16; and
c. a pair of Anaplasma primers for a conserved Anaplasma phagocytophilum (APH) 1387 gene sequence of A. phagocytophilum having the respective sequences of SEQ ID Nos: 18 and 19, or of SEQ ID Nos: 26, and 27 and an Anaplasma-specific molecular beacon probe having the sequence of SEQ ID No: 20,
wherein each of said primer pairs amplifies an amplicon that is 70-300 base pairs in length, wherein primer annealing is performed at a temperature below or equal to a primer-extension temperature during an amplification reaction, and wherein each molecular beacon probe is labeled with a spectrally distinguishable fluorescent or luminescent signaling moiety.
US Pat. No. 10,480,037

METHODS AND SYSTEMS FOR PREDICTING HIV-1 CORECEPTOR TROPISM

Laboratory Corporation of...

1. A method for treating a patient having a human immunodeficiency virus 1 (HIV-1) infection based on the tropism of the HIV-1 present in a sample from the patient, comprising:(a) analyzing a biological sample obtained from a clinical patient to obtain an amino acid sequence, nucleic acid sequence, or both, of at least one portion of an envelope or envelope coding region of the viruses from the biological sample, wherein the at least one portion of the envelope or envelope coding region comprises the variable region 3 (V3) loop or coding region;
(b) comparing the amino acid sequence, nucleic acid sequence, or both, of the at least one portion of the envelope or envelope coding region to sequence data stored in a database that comprises sequence and tropism data of a statistically significant number of viral isolates, wherein the comparing comprises a case based reasoning (CBR) analysis, and wherein the data comprises a plurality of sequences for the portion of the envelope or envelope coding region from viruses for which the tropism has been evaluated;
(c) determining the tropism of the viruses from the biological sample based on the CBR analysis, wherein the tropism is X4 tropic, R5 tropic, or dual or mixed tropic (DM); and
(d) treating the patient with an effective amount of an entry inhibitor based on the tropism determined in step (c).
US Pat. No. 10,479,782

FORMS OF LUMACAFTOR AND PROCESSES FOR THE PREPARATION THEREOF

Mylan Laboratories Limite...

1. A crystalline lumacaftor acetic acid solvate.
US Pat. No. 10,478,508

COMPOSITIONS, METHODS AND USES FOR ALPHA-1 ANTITRYPSIN FUSION MOLECULES

The Regents of the Univer...

1. A nucleic acid construct encoding a fusion polypeptide represented by SEQ ID NO: 49, SEQ ID NO: 56, SEQ ID NO: 57, or SEQ ID NO: 58.
US Pat. No. 10,481,073

BASOPHIL ANALYSIS SYSTEM AND METHOD

Abbott Laboratories, Abb...

1. A hematology analyzer for conducting a basophil analysis on a blood sample that contains a plurality of basophils and lymphocytes, the analyzer comprising:an excitation source positioned to excite particles within the blood sample;
a detector unit comprising a fluorescence detector positioned to measure fluorescence emitted from the excited blood sample; and
a processor;
a non-transitory computer-readable memory medium comprising instructions that cause the processor to:
excite the blood sample with an excitation source in a flow cell;
collect a plurality of fluorescence emission signals from the excited sample;
prior to performing a basophil analysis, exclude nuclei-free events and retain nuclei-containing events using only a fluorescence trigger that is limited to fluorescence emission signals and is set to a fluorescence magnitude that is greater than fluorescence emission signals from RBCs, including RBC fragments, and is less than fluorescence emission signals from white blood cells (WBCs); and
perform a basophil cluster analysis on the nuclei-containing events.
US Pat. No. 10,480,051

FCC MATERIALS OF ALUMINUM, COBALT, IRON AND NICKEL, AND PRODUCTS MADE THEREFROM

ARCONIC INC., Pittsburgh...

1. A method comprising:(a) using a feedstock in an additive manufacturing apparatus, wherein the feedstock comprises:
4.4-11.4 wt. % Al;
4.9-42.2 wt. % Co;
4.6-28.9 wt. % Fe; and
44.1-86.1 wt. % Ni;
(b) producing a metal product in the additive manufacturing apparatus using the feedstock.
US Pat. No. 10,479,797

MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO

Arena Pharmaceuticals, In...

1. A compound selected from the following compounds and pharmaceutically acceptable salts, solvates, and hydrates thereof:(S)-1-(3-(2-hydroxyethylsulfonyl)phenoxy)-3-((R)-8-(quinolin-3-ylsulfonyl)-1-oxa-8-azaspiro[4.5]decan-3-ylamino)propan-2-ol (Compound 88);
3-((R)-3-((S)-3-(3-(cyclopropylsulfonyl)phenoxy)-2-hydroxypropylamino)-1-oxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-1-ethylquinolin-4(1H)-one (Compound 297);
(S)-1-((R)-8-(1H-pyrrolo[3,2-b]pyridin-6-ylsulfonyl)-1-oxa-8-azaspiro[4.5]decan-3-ylamino)-3-(3-(cyclopropylsulfonyl)phenoxy)propan-2-ol (Compound 309);
1-ethyl-3-((R)-3-((S)-2-hydroxy-3-(3-(methylsulfonyl)phenoxy)propylamino)-1-oxa-8-azaspiro[4.5]decan-8-ylsulfonyl)quinolin-4(1H)-one (Compound 310);
3-((R)-3-((S)-3-(3-(cyclopropylsulfonyl)phenoxy)-2-hydroxypropylamino)-1-oxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-1-ethyl-8-methylquinolin-4(1H)-one (Compound 315);
3-((R)-3-((S)-3-(3-(cyclopropylsulfonyl)phenoxy)-2-hydroxypropylamino)-1-oxa-8-azaspiro[4.5]decan-8-ylsulfonyl)quinolin-4(1H)-one (Compound 326); and
3-((R)-3-((S)-3-(3-(cyclopropylsulfonyl)phenoxy)-2-hydroxypropylamino)-1-oxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-1-ethyl-8-fluoroquinolin-4(1H)-one (Compound 333).