US Pat. No. 10,428,437

WEAR-RESISTANT COATING PRODUCED BY ELECTRODEPOSITION AND PROCESS THEREFOR

MTU AERO ENGINES AG, Mun...

1. A coating, wherein the coating is wear-resistant and comprises an electrodeposited matrix which comprises from 15% by weight to 50% by weight Co, from 15% by weight to 50% by weight Ni, from 10% by weight to 30% by weight Cr, and from 1% by weight to 10% by weight Al, and in which first particles comprising hard material particles and/or slip material particles are incorporated in a proportion of from 5% by volume to 40% by volume.

US Pat. No. 10,428,436

INDIUM ELECTROPLATING COMPOSITIONS CONTAINING AMINE COMPOUNDS AND METHODS OF ELECTROPLATING INDIUM

Rohm and Haas Electronic ...

1. A method comprising:a) providing a substrate comprising a nickel layer;
b) contacting the substrate with an indium electroplating composition comprising one or more sources of indium ions, citric acid, salts thereof or mixtures thereof, and one or more amine compounds in amounts of 0.1 ppm to 100 ppm having a formula:

where R1 is chosen from hydrogen; (CH2)aNR4R5 where R4 and R5 are independently chosen from hydrogen and linear or branched (C1-C4)alkyl and a is an integer of 1 to 4 (CH2CHR6—O)xH or salts thereof where R6 is chosen from hydrogen or linear of branched (C1-C4)alkyl and x is an integer from 1 to 20; carboxy(C1-C4)alkyl or salts thereof; or (CH2CHR6—O)p(CH2CHR9—O)xH or salts thereof where R9 is hydrogen or linear or branched (C1-C4)alkyl; R2 is chosen from hydrogen; linear or branched (C1-C4)alkyl; (CH2CHR6—O)yH of salts thereof where R6 is defined as above and y is an integer of 1 to 20; carboxy(C1-C4)alkyl or salts thereof; or (CH2CHR6—O)q(CH2CHR10—O)yH or salts thereof where R10 is hydrogen or linear or branched (C1-C4)alkyl; R3 is chosen from cocoalkyl; R?—O—(CH2)m where R? is chosen from linear or branched, saturated or unsaturated (C1-C20)alkyl, m is an integer of 1 to 4; (CH2)mNR7R8 where R7 is (CH2CHR6—O)p(CH2CHR9—O)xH or salts thereof and R8 is (CH2CHR6—O)q(CH2CHR10—O)yH or salts thereof; p and q are integers from 1-20; and G is (CH2CHR6—O)zH or salts thereof where z is an integer from 1 to 20 and n is 0 or 1; and wherein the indium electroplating composition is free of alloying metals; and
c) electroplating an indium metal layer on the nickel layer of the substrate with the indium electroplating composition.

US Pat. No. 10,428,435

METHOD FOR MODIFYING AN ELECTRICALLY CONDUCTIVE OXIDE SURFACE, USE FOR ELECTRODEPOSITION OF COPPER ON SAID SURFACE

1. Method for modifying the surface of an Indium Tin Oxide (ITO) substrate, said method comprising the following steps consisting in:i) bringing into contact the surface of said ITO substrate with a solution containing at least one copper ion (Cu2+) and at least ammonia then washing and optionally drying the surface of said ITO substrate thus obtained;
ii) bringing into contact the surface of said ITO substrate obtained following step (i) with a solution containing sodium tetraborohydride then washing and optionally drying the surface of said ITO substrate, whereby the ITO substrate surface that is obtained after step (ii) is a modified surface that does not present nanoparticles or clusters of copper.

US Pat. No. 10,428,433

METHOD TO REGENERATE OXYGEN TRAPS

CENTRE NATIONAL DE LA REC...

1. A method to regenerate an oxygen trap using an electric current, comprising at least the following steps:a) circulating, by a circuit and a voltage source, an electric current in a material of the trap to reduce the material;
b) measuring, by an ammeter, a value Im of said electric current and estimating a derivative dIm/dt of the measured current Im in relation to time;
c) estimating, by a calculator, a length (?) of material reduced by said electric current, as a function of the value of said current (Im) and of said derivative (dIm/dt);
d) stopping, by a switch, circulation of the current when the length of reduced material is at least equal to a threshold value (?s).

US Pat. No. 10,428,432

CATALYST LAYERS AND ELECTROLYZERS

Dioxide Materials, Inc., ...

1. A catalyst layer for an electrochemical device comprising a catalytically active element and an ion conducting polymer wherein said ion conducting polymer comprises:(a) positively charged cyclic amine groups; and
(b) polymers or copolymers of styrene, and wherein the weight of the ion conducting polymer in the catalyst layer is less than 64% of the weight of the catalytically active element.

US Pat. No. 10,428,431

MULTI-LAYER WATER-SPLITTING DEVICES

AQUAHYDREX PTY LTD, Nort...

1. A water splitting device comprising at least one cathode and at least one anode, wherein at least one liquid-permeable and gas-permeable spacer layer is positioned between the at least one cathode and the at least one anode, and wherein the water splitting device is arranged so that liquid electrolytes can permeate through the at least one liquid-permeable and gas-permeable spacer layer and thus be in fluid communication with both the at least one cathode and the at least one anode, wherein the spacer layer comprises embossed structures defining microfluidic plumbing structures configured for transmission of gas.

US Pat. No. 10,428,430

MARINE UTILITY CAST IRON ANODE

1. A marine utility anode sled, comprising:at least two generally parallel lateral members having lateral member centerlines and made of an anodic material;
at least two generally parallel longitudinal members attached to reside generally perpendicular to the lateral members and having longitudinal member centerlines above the lateral member centerlines of the lateral members and made of an anodic material; and
at least one electrical cable in electrical communication with the anodic material of both the lateral members and longitudinal members.

US Pat. No. 10,428,427

FABRICATION METHOD FOR TWO-DIMENSIONAL MATERIALS

NATIONAL CHIAO TUNG UNIVE...

1. A fabrication method for two-dimensional materials, comprising the following steps:forming an amorphous thin film having at least one element on a substrate;
forming at least one capping layer on the amorphous thin film; and
annealing the amorphous thin film to form a two-dimensional material film after the capping layer is formed, wherein the two-dimensional material film is a crystalline material formed from the at least one element;
wherein the step for forming the capping layer comprises:
forming a first capping layer on the amorphous thin film by using evaporation; and
forming a second capping layer on the first capping layer by using plasma-enhanced chemical vapor deposition,
wherein a density of the second capping layer is larger than a density of the first capping layer.

US Pat. No. 10,428,425

FILM DEPOSITION APPARATUS, METHOD OF DEPOSITING FILM, AND NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM

Tokyo Electron Limited, ...

1. A film deposition apparatus for sequentially supplying at least two reaction gases, which mutually react, into a chamber to deposit a film on a substrate, the film deposition apparatus comprising:a turntable configured to be rotatable and include a concave portion on an upper surface, a bottom portion of the concave portion having a through hole;
a substrate supporting member configured to be attachable to and detachable from the concave portion, an upper surface of the substrate supporting member being configured to mount the substrate, a lower surface of the substrate supporting member being configured to have a first protruding portion;
a drive mechanism configured to move up and down the turntable, and revolve the turntable;
a lid member located inside the chamber and lower than the turntable, an upper surface of the lid member having a second protruding portion; and
a control unit configured to, after the drive mechanism moves down the turntable, revolve the turntable to cause the first protruding portion to contact the second protruding portion and cause the substrate supporting member to move to be spun a predetermined angle relative to the turntable.

US Pat. No. 10,428,424

TRAY DEVICE, REACTION CHAMBER AND MOCVD APPARATUS

BEIJING NAURA MICROELECTR...

1. A tray device, comprising:a large tray; a rotating shaft; a small tray; and a supporting disk,
wherein
the rotating shaft is connected with a center of the large tray and is configured to drive the large tray to rotate about the rotating shaft,
a tray groove configured to place the small tray therein is provided on the large tray, and
the supporting disk is located under the large tray, a sliding mechanism is provided between the supporting disk and the small tray, and, when the small tray revolves along with the large tray, the small tray is driven to spin in response to a sliding operation of the sliding mechanism, and the small tray is supported by the supporting disk by means of the sliding mechanism,
the sliding mechanism comprises a first sliding groove and a sliding pin, the first sliding groove being formed at an upper surface of the supporting disk, the first sliding groove being a closed track, an upper end of the sliding pin being fixedly connected to a first position other than a center of the small tray, a lower end of the sliding pin contacting the first sliding groove, and the sliding pin being configured to move along the first sliding groove, and when the large tray rotates about the rotating shaft, the first sliding groove on the supporting disk being fixed.

US Pat. No. 10,428,423

METHOD AND APPARATUS FOR DEPOSITING ATOMIC LAYERS ON A SUBSTRATE

1. A method of depositing an atomic layer on a substrate, the method comprising:supplying a precursor gas from a precursor-gas supply comprised in a drum; the drum being rotatable with respect to a sealing piece that receives gas from a gas source, wherein one of the drum and sealing piece comprises one or more gas feed channels in fluid connection with the precursor-gas supply, wherein the other of the drum and sealing piece comprises one or more circumferential grooves in its surface sealed by the one of the drum and sealing piece thereby preventing a fluid flowpath in a radial direction and leaving a fluid flow path in a circumferential direction, wherein during the supplying the precursor gas from the precursor-gas supply towards the substrate, the gas feed channels abut the sealed grooves, wherein a part of the gas flow path is formed by the sealed grooves, and wherein at least one sealed groove is provided with one or more separations separating adjacent zones of process gas feeds in the sealed groove, thus allowing zones to provide for mutually differing process gas compositions; and
providing a relative motion between the precursor-gas supply and the substrate to have the precursor gas react on the substrate so as to form an atomic layer by rotating the drum along a rotation trajectory while supplying the precursor gas; thus depositing a stack of atomic layers of a gradient composition,
wherein the at least one groove is formed by an upstanding wall that is sealed by an abutting face of one of the sealing piece or the drum, and
wherein the separations are recessed relative to the upstanding wall thereby forming a flow restriction relative the abutting face in order to provide a controlled cross flow between adjacent zones.

US Pat. No. 10,428,422

FILM-FORMING METHOD

PHILTECH Inc., Tokyo (JP...

1. A film-forming method for forming a film in a film-forming apparatus including (i) a first accumulation mechanism in which a first source gas is accumulated and a second accumulation mechanism in which a second source gas is accumulated, (ii) a first instantaneously-heating unit connected to the first accumulation mechanism that heats the first source gas, and a second instantaneously-heating unit connected to the second accumulation mechanism that heats the second source gas, wherein each of the first and second instantaneously-heating units heats each of the first and second source gases respectively by causing each of the first and second source gases to vertically collide with a flow path wall of a flow path formed on a surface of a heat exchange substrate electrically heated to cause heat exchange between each of the first and second source gases and the flow path wall, and (iii) a reaction chamber in which a substrate whose temperature is lower than a heating temperature of each of the first and second instantaneously-heating units is placed, comprising:generating first gas molecular species by causing the first source gas in an amount accumulated in the first accumulation mechanism to pass through the first instantaneously-heating unit, and generating second gas molecular species by causing the second source gas in an amount accumulated in the second accumulation mechanism to pass through the second instantaneously-heating unit;
sharply raising a partial pressure of the first gas molecular species and a partial pressure of the second gas molecular species by projectingly supplying the first gas molecular species and the second gas molecular species so that the partial pressures of the first and second gas molecular species make projecting peaks to the reaction chamber in which the substrate has been placed, which has been depressurized, and which has a constant capacity;
bringing the first gas molecular species or the second gas molecular species into reaction by alternately repeatedly guiding the first gas molecular species or the second gas molecular species to a surface of the substrate; and
forming a compound film on the surface of the substrate by supplying the first and second gas molecular species with repeated depressurization and projecting supply.

US Pat. No. 10,428,421

SELECTIVE DEPOSITION ON METAL OR METALLIC SURFACES RELATIVE TO DIELECTRIC SURFACES

ASM IP Holding B.V., Alm...

1. A method for selectively depositing a material on a first metal or metallic surface of a substrate relative to a second surface dielectric surface of the substrate, the method comprising one or more deposition cycles comprising:contacting the substrate with a first vapor-phase precursor comprising a metal halide at a temperature equal to or above about 225° C., wherein the metal halide is selected from fluorides or chlorides of Nb, Ta, Mo, W, V, Cr;
contacting the substrate with a second vapor-phase precursor comprising water or H2O2; and
optionally repeating the contacting steps until a desired thickness of material is deposited on the first metal or metallic surface;
wherein the material is deposited on the first metal or metallic surface relative to the second dielectric surface with a selectivity of above about 50%.

US Pat. No. 10,428,420

METHOD FOR CONTROLLING A PROCESSING SYSTEM

APPLIED MATERIALS, INC., ...

1. A method, comprising:flowing a precursor gas into a processing chamber;
injecting an inert gas directly into an exhaust line at a location between the processing chamber and an abatement system downstream of the processing chamber, wherein the inert gas bypasses the processing chamber; and
controlling the flow of the inert gas based on the flow of the precursor gas, wherein the flowing of the inert gas is controlled in response to a change to the flowing of the precursor gas.

US Pat. No. 10,428,419

COMBINATION CVD/ALD METHOD, SOURCE AND PULSE PROFILE MODIFICATION

ASM IP Holding B.V., Alm...

1. A method of operating a system having a reactor configured to deposit a thin film, said method comprising:providing a first amount of a reactant from a reactant source vessel to a reaction space of the reactor at a first volumetric flow rate,
subsequently providing a pulse flow of a second amount of the reactant to the reaction space at a second volumetric flow rate which is greater than said first volumetric flow rate, the pulsed flow comprising a pulse time duration,
removing at least a portion of the second amount of the reactant from the reaction space via delivery of a purge gas to the reaction space,
wherein the providing a first amount of a reactant, providing a pulsed flow of the second amount of the reactant, and removing a portion of the second amount of the reactant are repeated multiple times to deposit the thin film, and
wherein each pulsed flow of the second amount of the reactant entering the reaction space includes less than half of a total amount of the second reactant within a first half of the pulse time duration, thereby initially providing a low partial pressure pulsed flow of the second reactant to the reaction space during each pulsed flow.

US Pat. No. 10,428,418

METAL MATERIAL AND A METHOD FOR USE IN FABRICATING THEREOF

CITY UNIVERSITY OF HONG K...

1. A metal material comprising a plurality of metal particles arranged in a structure having at least two phases including a crystalline phase and an amorphous phase; wherein the crystalline phase is arranged to form a plurality of spherical crystalline structures and the amorphous phase is arranged to surround the spherical crystalline structures such that the spherical crystalline structures are substantially free of dislocation.

US Pat. No. 10,428,412

ARTIFICIAL AGING OF STRAINED SHEET METAL FOR STRENGTH UNIFORMITY

FORD MOTOR COMPANY, Dear...

1. A method, comprising:forming a sheet of solution heat-treated, quenched, and aged 6xxx series aluminum having a sheet average yield strength of at least 100 MPa into a component;
attaching the component to an assembly;
painting at least a portion of the assembly; and
heat treating the assembly to cure the paint and to increase a component average yield to at least 240 MPa,
the heat treating step consists of a first heat treatment at a temperature of 170° C. to 190° C. for 5 to 15 minutes, followed by a second heat treatment at a temperature of 140° C. to 160° C. for 5 to 15 minutes, followed by a third heat treatment at a temperature of 130° C. to 150° C. for 5 to 15 minutes.

US Pat. No. 10,428,411

AIR QUENCHED HEAT TREATMENT FOR ALUMINUM ALLOYS

Ford Global Technologies,...

1. A method of processing an air-quenchable aluminum alloy component, comprising:sequentially performing operations of
progressive die stamping a sheet of an air-quenchable aluminum alloy to form a component,
solution heat treating the component,
air-quenching the component at a rate of 6° C./s to 25° C./s, and
artificially aging the component, including heat treating the component at 235° C. to 255° C., to a yield strength of at least 200 MPa.

US Pat. No. 10,428,407

CYLINDRICAL MEMBER MADE OF FLAKE GRAPHITE CAST IRON

TPR CO., LTD., Tokyo (JP...

1. A cylindrical member made of flake graphite cast iron,the flake graphite cast iron comprising a composition containing, in terms of mass %, 2.85% or more and 3.35% or less of C, 1.95% or more and 2.55% or less of Si, 0.45% or more and 0.8% or less of Mn, 0.03% or more and 0.25% or less of P, 0.15% or less of S, 0.15% or more and 0.55% or less of Cr, 0.15% or more and 0.65% or less of Mo, 0.15% or more and 0.65% or less of Ni, and the balance of Fe and inevitable impurities,
wherein the cylindrical member has a thickness of 3.5 mm or less.

US Pat. No. 10,428,406

WEAR RESISTANT AND CORROSION RESISTANT COBALT-BASED ALLOY POWDERS AND APPLICATIONS THEREOF

KENNAMETAL INC., Latrobe...

1. An article comprising:a metallic substrate; and
an alloy coating adhered to the metallic substrate via high velocity oxygen fuel (HVOF) spraying or high velocity air fuel (HVAF) spraying followed by sintering, the alloy coating comprising 15-25 wt. % chromium, 15-20 wt. % molybdenum, 0-15 wt. % tungsten, 10-20 wt. % nickel, 2.5-3.5 wt. % boron, 2.5-4.5 wt. % silicon, 1-2 wt. % carbon and the balance cobalt, wherein microstructure of the alloy comprises Co—Mo—Si Laves phases and intermetallic phases including metal borides and metal carbides.

US Pat. No. 10,428,405

EXTRACTANT AND METHOD FOR EXTRACTING AND SEPARATING YTTRIUM

XIAMEN INSTITUTE OF RARE ...

1. A method for the extraction and separation of yttrium, comprising:(1) mixing an extractant with a diluent to obtain an organic solution,
wherein the extractant is a compound or a mixture of compounds of formula (1):

wherein,
X is P or N; and
all of R1, R2, R3, and R4 are n-butyl, or one of R1, R2, R3, and R4 is n-tetradecyl and the other three of R1, R2, R3, and R4 are n-butyl;
(2) in a first extraction step, mixing the organic solution obtained in step (1) with an aqueous solution containing yttrium and other rare earth compounds to undergo selective extraction, so that yttrium remains in an aqueous phase while the other rare compounds are extracted into an organic phase; and
(3) in a back-extraction step, mixing the organic phase obtained from step (2) with an aqueous inorganic acid solution to extract the other rare earth compounds from the organic phase into the aqueous inorganic acid solution, wherein a molar concentration of the inorganic acid in the aqueous inorganic acid solution is 0.005 mol/l to 0.5 mol/l.

US Pat. No. 10,428,404

METHOD OF CONVERTING COPPER CONTAINING MATERIAL

OUTOTEC (FINLAND) OY, Es...

1. A method of converting copper containing material to blister copper comprising the following steps:(a) providing copper containing material comprising copper sulfides and iron sulfides, whereby the copper containing material comprises at least 35 wt % copper of the total weight of the copper containing material;
(b) reacting the copper containing material in a furnace with an oxygen containing gas, in the absence of flux, to effect oxidation of iron sulfide and copper sulfide, and controlling injection of the oxygen containing gas and the temperature so that a resulting converter slag is in a molten phase to obtain blister copper and converter slag, wherein in step (b) the oxygen partial pressure (pO2) is from 1 to 100 Pa.

US Pat. No. 10,428,403

METHOD FOR MANUFACTURING GRAIN-ORIENTED ELECTRICAL STEEL SHEET

JFE STEEL CORPORATION, C...

1. A method for manufacturing a grain-oriented electrical steel sheet, the method comprising:heating a steel slab having a composition that contains, in mass %, C: 0.08% or less, Si: 4.5% or less, and Mn: 0.5% or less, and that contains, in mass ppm, S: less than 50 ppm, Se: less than 50 ppm, O: less than 50 ppm, N: less than 60 ppm, and sol.A1: less than 100 ppm, and the balance consisting of Fe and incidental impurities;
subjecting the steel slab to hot rolling to obtain a hot rolled sheet;
optionally subjecting the hot rolled sheet to hot band annealing;
subjecting the hot rolled sheet to cold rolling either once, or twice or more with intermediate annealing performed therebetween, to thereby obtain a cold rolled sheet having a final thickness;
subjecting the cold rolled sheet to decarburization annealing to obtain a decarburization annealed sheet;
applying an annealing separator mainly composed of MgO on a surface of the decarburization annealed sheet; and
then subjecting the decarburization annealed sheet to secondary recrystallization annealing,
wherein the cold rolling comprises final cold rolling with a total cold rolling reduction being set to 85% or more and a rolling reduction per pass being set to 32% or more,
wherein the final cold rolling includes one or more passes followed by a final pass and uses work rolls having a mean surface roughness Ra of 0.25 ?m or less in at least one of the one or more passes other than the final pass, and
wherein the method further comprises, before initiating the final cold rolling, and after the hot rolling or the hot band annealing, heating both widthwise edges of the steel sheet to be subjected to the final cold rolling to a temperature from 100° C. to 400° C.

US Pat. No. 10,428,402

METHOD FOR HOT FORMING THIN SEMI-FINISHED PRODUCTS

1. A method for hot forming a semi-finished product of steel, the method comprising:heating the semi-finished product to a forming temperature;
conveying the semi-finished product to a forming tool;
forming at least one structure in the semi-finished product that increases rigidity of the semi-finished product, the at least one structure being formed at least partially in a trimming region of the semi-finished product, the trimming region defined as a portion of the semi-finished product that is removed resulting from cutting along a cutting line on the semi-finished product;
hot forming, hardening, or press hardening the semi-finished product in the forming tool after the at least one structure has been formed in the semi-finished product;
removing the trimming region from the semi-finished product thereby removing the structure wherein no remnants of the at least one structure remain on the semi-finished, formed and trimmed semi-finished product of steel; and
forming the semi-finished product into an A-pillar, a B-pillar, or a C-pillar of a motor vehicle.

US Pat. No. 10,428,401

THERMAL TREATMENT PROCESS OF A STEEL SHEET AND DEVICE FOR ITS IMPLEMENTATION

ArcelorMittal, Luxembour...

1. A thermal treatment process for a ferrous alloy sheet comprising the steps of:performing a thermal treatment on a running ferrous alloy sheet by immersing the ferrous alloy sheet into at least one molten oxides bath, the molten oxides bath having a viscosity lower than 3·10?1 Pa·s, a surface of the bath being in contact with a non-oxidizing atmosphere, the molten oxides being inert towards iron and a difference (?T) between a temperature of the ferrous alloy sheet at an entry of the bath and a temperature of the bath being between 25° C. and 900° C.; and
eliminating residues of molten oxides remaining on surfaces of the ferrous alloy sheet at an exit of the bath.

US Pat. No. 10,428,399

IMMERSION PROBE AND ASSEMBLY OF IMMERSION SUBLANCE AND IMMERSION PROBE FOR A CONVERTER FURNACE

ECIL MET TEC LTDA., Pied...

1. An immersion assembly for a converter furnace comprising: an immersion sublance comprising: a guide comprising a guide connecting end; and a sublance holder comprising a first coupling end and a second coupling end; wherein the guide connecting end of the guide is coupled to the first coupling end of the sublance holder; and wherein the sublance holder extends longitudinally from the first coupling end to the second coupling end; and an immersion probe comprising: a casing comprising an upper portion and having an internal cavity; and an adjustable portion located in the internal cavity, the adjustable portion comprising a connecting portion, an elastic portion, and a fixed portion, wherein the connecting portion is attached to the elastic portion and the elastic portion is attached to the fixed portion; and wherein the adjustable portion extends longitudinally along the internal cavity of the casing from the connecting portion to the fixed portion; wherein the second coupling end of the sublance holder of the immersion sublance is connected to the connecting portion of the adjustable portion of the immersion probe; wherein the connecting portion comprises a connector attached to a connection base, wherein the connector is located within the internal cavity of the casing, and wherein the connection base is attached to the elastic portion; wherein the elastic portion is disposed between the fixed portion and the connecting portion so that compression of the elastic portion decreases a length of the adjustable portion after a first contact point is established between a surface of the connection base of the connecting portion and a surface of the second coupling end of the sublance holder; and wherein the elastic portion is configured to compress until a second contact point is established between the upper portion of the casing of the immersion probe and the guide connecting end of the guide of the immersion sublance.

US Pat. No. 10,428,381

METHODS FOR DETECTION OF NUCLEOTIDE MODIFICATION

Cambridge Epigenetix Limi...

1. A method comprising:contacting a sample comprising a 5-hydroxymethylcytosine with a perruthenate oxidizing agent, wherein said perruthenate oxidizing agent selectively converts said 5-hydroxymethylcytosine to 5-formylcytosine.

US Pat. No. 10,428,380

MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA

THE TRUSTEES OF COLUMBIA ...

1. A method for sequencing a nucleic acid which comprises detecting the identity of a nucleotide analogue incorporated into the end of a growing strand of DNA in a polymerase reaction, wherein the nucleotide analogue is any of the following:
wherein R (a) represents a small, chemically cleavable, chemical group capping the oxygen at the 3? position of the deoxyribose of, the deoxyribonucleotide analogue, (b) does not interfere with recognition of the analogue as a substrate by a DNA polymerase, (c) is stable during a DNA polymerase reaction, (d) does not contain a ketone group, and (e) is not a —CH2CH?CH2 group;
wherein OR is not a methoxy group or an ester group;
wherein the covalent bond between the 3?-oxygen and R is stable during a DNA polymerase reaction;
wherein tag represents a detectable fluorescent moiety;
wherein Y represents a chemically cleavable, chemical linker which (a) does not interfere with recognition of the analogue as a substrate by a DNA polymerase and (b) is stable during a DNA polymerase reaction;
wherein the nucleotide analogue:
i) is recognized as a substrate by a DNA polymerase,
ii) is incorporated at the end of a growing strand of DNA during a DNA polymerase reaction,
iii) produces a 3?-OH group on the deoxyribose upon cleavage of R, and
iv) no longer includes a tag on the base upon cleavage of Y;
and wherein if the nucleotide analogue is: (A), it is capable of forming hydrogen bonds with cytosine or a cytosine nucleotide analogue; (B), it is capable of forming hydrogen bonds with thymine or a thymine nucleotide analogue; (C), it is capable of forming hydrogen bonds with guanine or a guanine nucleotide analogue; or (D), it is capable of forming hydrogen bonds with adenine or an adenine nucleotide analogue.

US Pat. No. 10,428,379

NUCLEOTIDE ANALOGS FOR SEQUENCING

IBIS BIOSCIENCES, INC., ...

1. A nucleotide analog comprising:a) a nucleotide comprising a phosphate moiety, a base, and a sugar;
b) a photocleavable terminating moiety attached to the nucleotide by a first photocleavable linker, wherein said photocleavable terminating moiety is electrochemically detectable by accepting or donating at least one electron during an electrochemical reaction; and
c) a second photocleavable terminating moiety attached to the nucleotide by a second photocleavable linker.

US Pat. No. 10,428,377

METHODS OF DETECTING LOW COPY NUCLEIC ACIDS

CALIPER LIFE SCIENCES, IN...

8. A method of detecting a low copy nucleic acid of interest in a sample that comprises a higher copy additional nucleic acid that is different from the low copy nucleic acid, the method comprising:aliquotting the sample into a plurality of reaction mixtures, which reaction mixtures comprise a plurality of zero copy reaction mixtures comprising zero copies of the nucleic acid of interest and at least one single copy reaction mixture comprising a single copy of the nucleic acid of interest;
simultaneously subjecting the zero and single copy reaction mixtures in parallel to an amplification reaction while flowing each of the plurality of reaction mixtures through one of a plurality of channels of a microfluidic device;
detecting the nucleic acid of interest in the single copy reaction mixture;
wherein at least one of the plurality of reaction mixtures is formulated in an aqueous phase of an emulsion comprising aqueous droplets suspended in and surrounded by an immiscible liquid.

US Pat. No. 10,428,375

NUCLEIC ACID AMPLIFICATION AND DETECTION APPARATUS AND METHOD

AXXIN PTY LTD, Melbourne...

1. A nucleic acid amplification and detection apparatus, including:a support configured to receive a plurality of reaction vessels containing respective samples of one or more nucleic acids to be amplified, the support being rotatable about an axis of rotation and the reaction vessels being received in the support at respective receiving locations distributed about the axis of rotation;
a temperature control component thermally coupled to the support and configured to control the temperature of the support in order to amplify the nucleic acids contained in the reaction vessels while received in the support;
a plurality of measurement components configured to measure respective characteristics of the nucleic acids within the reaction vessels at respective measurement locations distributed about the axis of rotation, wherein the measurement components are arranged radially outward with respect to the reaction vessels;
a stepper motor coupled to the support and configured to rotate the support about the axis of rotation; and
a sample position controller coupled to the stepper motor and being configured to:
(i) cause the stepper motor to rotate the support about the axis of rotation in an oscillatory manner to cause mixing of the contents of the reaction vessels; and
(ii) cause the stepper motor to selectively position and hold a selected one of the plurality of reaction vessels at a selected one of the plurality of measurement locations to allow a corresponding one of the plurality of measurement components to perform a corresponding measurement on a corresponding sample.

US Pat. No. 10,428,374

LIQUID DISPENSING DEVICE

Kimantech, LLC, Salt Lak...

1. A liquid dispensing system, comprising:a support member;
a plurality of penetrating tips fixedly coupled to the support member, each penetrating tip operable to penetrate a container having a liquid disposed therein and create an opening in a portion of the container to dispense the liquid; and
a plurality of receptacles, each receptacle comprising a well of an electrophoresis gel configured to receive the liquid dispensed from the container.

US Pat. No. 10,428,372

PROBE SYSTEM FOR REAL-TIME QUANTITATIVE AND QUALITATIVE ANALYSIS OF BIOMATERIAL, REACTION CHAMBER WITH SAID PROBE SYSTEM, AND ANALYSIS METHOD THEREOF

SUGENTECH, INC., Daejeon...

1. A method for real-time quantitative and qualitative analysis of a biomaterial, comprising:(a) introducing a test sample into a reaction chamber,
wherein the reaction chamber has a top opening and the test sample accommodated therein and is hermetically closed with a cap installed at the opening after introduction of the test sample, wherein a bottom surface of the reaction chamber comprises an optically transmissive window having an optically transmissive flat surface; a biochip is formed on the optically transmissive window; a target probe-reporter probe linker, which comprises a target probe, which has a sequence complementary to a target nucleic acid sequence to be detected, and comprises a first fluorophore and a first quencher, and a reporter probe linked to an end of the target probe and having a sequence non-complementary to the target nucleic acid sequence, is accommodated in the reaction chamber; and the biochip comprises a capture probe having a complementary sequence capable of hybridizing with the non-complementary sequence of the reporter probe and comprising a second fluorophore and a second quencher;
(b) hybridizing and amplifying,
wherein, when the target probe is hybridized with target nucleic acids of the test sample, a first fluorescence signal is generated from the first fluorophore of the target probe while the target probe is digested with a polymerase having nuclease activities, the reporter probe is digested from the target probe with the polymerase having the nuclease activities to be released into the reaction chamber, and the capture probe having the complementary sequence is hybridized with the non-complimentary sequence of the reporter probe released into the reaction chamber to emit a second fluorescence signal due to a structural change of the capture probe caused by an extension reaction; and
(c) detecting the first and second fluorescence signals,
wherein quantitative analysis of the target nucleic acids from the first fluorescence signal is performed, and qualitative analysis of the target nucleic acids from the second fluorescence signal is performed.

US Pat. No. 10,428,371

FLUORESCENT LABELED SINGLE-STRANDED NUCLEIC ACID AND USE THEREOF

KABUSHIKI KAISHA DNAFORM,...

1. A labeled single-stranded nucleic acid comprising at least two fluorescent atomic group pairs that exhibit an exciton effect within each fluorescent atomic group pair, whereinan emission peak wavelength of a fluorescent atomic group pair J is shorter than an excitation peak wavelength of a fluorescent atomic group pair K,
the fluorescent atomic group pair J and the fluorescent atomic group pair K are both cations,
the fluorescent atomic group pairs J and K have a Förster resonance energy transfer (FRET) effect between each other,
each of a base having the fluorescent atomic group pair J or K that exhibits an exciton effect has a structure represented by the following formula (16), (16b), (17), or (17b):
where in the formulae (16), (16b), (17), and (17b),Z11 and Z12 are each a fluorescent atomic group that exhibits an exciton effect, and may be identical to or different from each other,
Z11 and Z12 constitute a fluorescent atomic group pair,
B is an atomic group having a natural nucleobase skeleton or an artificial nucleobase skeleton, wherein the natural nucleobase is adenine, guanine, cytosine, thymine or uracil,
E is:
(i) an atomic group having a deoxyribose skeleton, a ribose skeleton, or a structure derived from either one of them, or
(ii) an atomic group having a peptide structure or a peptoid structure,
L1, L2, and L3 are each a linking atom or a linking atomic group, having any number of main chain atoms, each may or may not contain each of C, N, O, S, P, and Si in the main chain, each may or may not contain each of a single bond, a double bond, a triple bond, an amide bond, an ester bond, a disulfide bond, an imino group, an ether bond, a thioether bond, and a thioester bond in the main chain, and may be identical to or different from each other,
D is CR, N, P, P?O, B, or SiR where R is a hydrogen atom, an alkyl group, or any substituent, and
b is a single bond, a double bond, or a triple bond, or alternatively,
in the formulae (16) and (16b), L1- and L2 are each a linker, L3, D, and b may not be present, and L1 and L2 may be bound directly to B, provided that:
in the formulae (16) and (17), E is an atomic group described in the item (i), and at least one O atom in a phosphoric acid linkage may be substituted with an S atom;
in the formulae (16b) and (17b), E is an atomic group described in the item (ii);
in the formulae (17) and (17b), the respective Bs may be identical to or different from each other, and the respective Es may be identical to or different from each other; and
the base having the fluorescent atomic group pair J and the base having the fluorescent atomic group pair K are contained in the labeled single-stranded nucleic acid at a distance at which there are from 1 to 5 bases between the base having the fluorescent atomic group pair J and the base having the fluorescent atomic group pair K.

US Pat. No. 10,428,370

UNIVERSAL METHOD FOR EXTRACTING NUCLEIC ACID MOLECULES FROM A DIVERSE POPULATION OF ONE OR MORE TYPES OF MICROBES IN A SAMPLE

Sun Genomics, Inc., San ...

1. A method comprising:extracting genetic material from any microbes present in a first sample obtained from the subject by: i) mixing the sample with a first lysis solution comprising a detergent, and a chelator; ii) adding a second lysis solution having a lysozyme to the mixture of step i); and iii) adding a third lysis solution comprising a chaotropic agent, to the mixture of step ii);
subjecting the genetic material extracted from the first sample to metagenomics analysis;
diagnosing the subject as having dysbiosis based on the metagenomics analysis of the first sample;
administering a probiotic to the subject to treat the dysbiosis;
extracting genetic material from any microbes present in a second sample obtained from the subject in the same manner as the extraction of genetic material from the first sample;
performing metagenomics analysis on the extracted genetic material from the second sample; and
assessing effectiveness of the dysbiosis treatment; and
administering a modified probiotic which is formulated specifically to the dysbiosis in the subject and based on the assessment of effectiveness, to the subject to treat the dysbiosis.

US Pat. No. 10,428,369

ANALYZING MICRODROPLET OUTLINE SIZE AND ADJUSTING CHANNEL PRESSURE TO ALTER MICRODROPLET SIZE

Bio-Rad Laboratories, Inc...

1. A method of analyzing a microdroplet, comprising:forming a microdroplet in a microfluidic channel;
obtaining a projected image of the microdroplet in the microfluidic channel, wherein the image includes a microdroplet outline;
measuring an outside diameter of the microdroplet outline;
measuring an inside diameter of the microdroplet outline;
analyzing the size of the microdroplet by using a midpoint diameter of the microdroplet outline, wherein the midpoint diameter is the average of the outside diameter and the inside diameter; and
adjusting pressure inside the microfluidic channel to alter the size of the microdroplet.

US Pat. No. 10,428,368

METHODS FOR ENRICHING FOR A POPULATION OF RNA MOLECULES

New England Biolabs, Inc....

1. A method of enriching for a population of RNA molecules in a mixture of RNAs, comprising:(a) adding a labeled GMP to the 5? end of 5?-diphosphorylated or 5?-triphosphorylated RNA molecules in a sample by incubating the sample with a labeled GTP and a capping enzyme, wherein the labeled GTP is of Formula (I):

 wherein the base is guanine, R is a linker and L is desthiobiotin; and
(b) enriching for RNA comprising the desthiobiotin.

US Pat. No. 10,428,367

PORTABLE GENETIC DETECTION AND ANALYSIS SYSTEM AND METHOD

ILLUMINA, INC., San Dieg...

1. A portable genetic detector system comprising:a plurality of portable detectors, wherein each portable detector comprises:
a housing;
an interface disposed on or in the housing and configured to receive input from an operator to control operation of the portable detector;
a sample receiving component disposed on or in the housing and configured to receive a biological sample wherein the biological samples are different from one another;
a reader disposed on or in the housing and configured to detect nucleic acids of interest in the biological sample to generate sample data;
a control system disposed on or in the housing and programmed to control the operation of the portable detector;
a locator configured to generate location information of the portable detector;
a transceiver disposed on or in the housing and configured to output the sample data generated by the reading component, wherein the sample data comprises data identifying nucleotides present in the biological sample; and
a display disposed on or in the housing and configured to display information related to the operation of the portable detector; anda remote processing system in communication with each of the plurality of portable detectors and separate from the plurality of portable detectors, wherein the remote processing system comprises:communications circuitry configured to receive the sample data and the location information from each of the plurality of portable detectors; and
a processor programmed to assemble a nucleic acid sequence of at least one biological sample based on the sample data; determine a sequence coverage for one or more regions of a genome based on sequence; and provide instructions to stop operation of the control system of each of the plurality of portable detectors when the sequence coverage has achieved a threshold and to provide new instructions to a subset of the plurality of portable detectors to analyze respective new biological samples, wherein the subset is selected based on the location information.

US Pat. No. 10,428,365

QUANTITATIVE STERILE FIELD ANALYSIS SYSTEM

1. A settle plate holder for a settle plate to collect airborne particulates in an operating room, said settle plate holder comprising:a planar circular base for securing a settle plate, said planar circular base having a top face and two opposing plate securing flanges extending perpendicularly from said top face and each having an upper abutting lip;
said planar circular base devoid of a side wall; and
a protective cover allowing airflow over a placed settle plate, said protective cover hingeably coupled to said planar circular base, said protective cover comprising two parallel arms extending across a substantial length of said planar circular base and an arcuate wire centered upon said two parallel arms.

US Pat. No. 10,428,345

CORN PLANT EVENT MON87460 AND COMPOSITIONS AND METHODS FOR DETECTION THEREOF

Monsanto Technology LLC, ...

3. A corn seed comprising the polynucleotide of SEQ ID NO: 2 or a complement thereof.

US Pat. No. 10,428,328

RESTORATION OF THE CFTR FUNCTION BY SPLICING MODULATION

YISSUM RESEARCH DEVELOPME...

1. A method for improving at least one clinical parameter of Cystic Fibrosis in a patient in need thereof, the method comprising administering a therapeutically effective amount of a synthetic polynucleotide molecule to said patient,wherein the synthetic polynucleotide molecule comprises a nucleotide sequence having a sequence of at least 18 consecutive nucleotide bases,
wherein said synthetic polynucleotide molecule binds to a pre-messenger RNA (pre-mRNA) transcript of the Cystic Fibrosis Trans-membrane conductance Regulator (CFTR) gene and suppresses exon 10 exclusion from the mature CFTR mRNA, and
wherein said nucleotide sequence is complementary to the nucleotide sequence set forth in SEQ ID NO: 2, or to a fragment thereof.

US Pat. No. 10,428,325

IDENTIFICATION OF ANTIGEN-SPECIFIC B CELL RECEPTORS

Adaptive Biotechnologies ...

1. A method for identifying antigen-specific B-cell receptor (BCR) sequences comprising:(A) incubating a plurality of B-cells with an antigen library displayed by an organism capable of displaying antigens;
(B) distributing the B-cells bound to antigens of the antigen library into a plurality of aliquots;
(C) isolating nucleic acids from B-cells bound to antigens of the antigen library and from the organism displaying said antigens;
(D) sequencing the following elements from each of the aliquots;
(i) B-cell heavy chain sequence,
(ii) B-cell light chain sequence, and
(iii) a nucleotide sequence encoding the antigen bound to the BCR; and
(E) identifying the sequenced elements of (D) that occur together in more than one aliquot thereby identifying antigen-specific BCR sequences.

US Pat. No. 10,428,323

REAGENTS AND METHODS FOR ESTERIFICATION

Wisconsin Alumni Research...

1. A method for esterifying one or more carboxylic acid groups in an organic or biological molecule which comprises contacting the organic or biological molecule with a compound of formula I:
or salts thereof, where:
R is an alkyl, alkenyl, alkynyl group or hydrogen,
RA is an alkyl or alkoxy at the para position on the indicated phenyl ring, and
RM is an alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or arylalkyl group which is optionally substituted with one or more alkyl, alkoxy, aryl, alkylaryl, halogen, haloalkyl, or haloalkoxy group.

US Pat. No. 10,428,309

SYSTEMS AND METHODS FOR PRODUCING STEM CELLS AND DIFFERENTIATED CELLS

New York Stem Cell Founda...

1. A method for the automated generation and/or manipulation of stem cells, the method comprising:a) providing an automated system having controller software,
b) culturing multiple different samples of cells, wherein the cells comprise adult somatic cells,
c) determining the proliferation rate or cell doubling time of individual cell samples from among the multiple different samples of cells utilizing an automated device having controller software for determining the proliferation rate or cell doubling time,
d) freezing individual cell samples from among the multiple different samples of cells,
e) selecting from the individual cell samples a subset of samples having similar proliferation rates or cell doubling times,
f) thawing the subset of samples selected in step (e),
g) plating the subset of samples in a multi-well plate,
h) culturing the subset of samples until they reach a desired confluency,
i) contacting the cultured subset of samples with one or more reprogramming factors in order to produce iPSCs, and
j) sorting the iPSCs and consolidating the sorted iPSCs to produce a pooled iPSC sample, wherein (a) to (j) are performed on the automated system via the controller software.

US Pat. No. 10,428,305

MODIFIED NATURAL KILLER CELLS THAT EXPRESS IL15 AND USES THEREOF

National University of Si...

1. A natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), wherein the all or a functional portion of the IL-15 is fused to all or a portion of a transmembrane protein that anchors the expressed IL-15 as a cell membrane-bound polypeptide (mbIL15) of the NK cell, and wherein the all or a functional portion of IL-15 promotes one or more of:(i) NK cell survival,
(ii) regulation of NK cell and T cell activation and proliferation, and
(iii) support of NK cell development from hematopoietic stem cells.

US Pat. No. 10,428,301

SYSTEM, APPARATUS AND METHOD FOR MATERIAL PREPARATION AND/OR HANDLING

Keck Graduate Institute, ...

1. A system to perform lysis, the system comprising:a container having at least one chamber to hold a material to be lysed and a lysing particulate material, the chamber having:
a first opening to provide fluid communication with the chamber from an exterior thereof and to receive the material to be lysed;
a second opening to provide fluid communication with the chamber from an exterior thereof and to provide an exit to the chamber for the material to be lysed;
a first filter positioned adjacent the second opening, the first filter having a plurality of apertures sized to pass the material that has been lysed and to block the lysing Particulate material;
a second filter positioned adjacent the first opening, the second filter having a plurality of apertures sized to pass the material to be lysed and to block the lysing particulate material;
a medium that includes the lysing particulate material and a fluid;
an impeller having a number of blades received in the chamber of the container; and
a micromotor coupled to the impeller, in operation, the micromotor turns the impeller which causes the impeller to agitate the material to be lysed in the chamber along with the medium that includes the lysing particulate material and the fluid to mechanically lyse the material.

US Pat. No. 10,428,300

CELL CULTURING DEVICE

HITACHI, LTD., Tokyo (JP...

1. An automatic cell culture system comprising:a culture vessel comprising a first vessel and a second vessel, the first vessel being positioned within the second vessel and having a culture surface formed of a permeable membrane;
wherein the first vessel comprises a first port configured to supply a liquid into the first vessel and discharge a gas from the first vessel, and a second port configured to discharge a liquid from the first vessel;
wherein the second vessel comprises a third port configured to supply a liquid into the second vessel and discharge a gas from the second vessel, and a fourth port configured to discharge a liquid from the second vessel;
the culture vessel further comprising:
at least one flow channel for discharging the gas discharged from the first port and the third port to outside air at atmospheric pressure;
at least one filter provided in the at least one flow channel; and
at least one collecting unit disposed between the first port and the third port, and the at least one filter in the at least one flow channel, the at least one collecting unit collecting moisture from the discharged gas.

US Pat. No. 10,428,299

MIXING DEVICE FOR MIXING THE CONTENTS OF A CONTAINER

Sartorius Stedim Biotech ...

1. A mixing device (1) for mixing contents of a container (12), the container having a removal side (17) that defines a side of the container (12) designated for collection and removal of the contents of the container (12), comprising:a container support (3) configured for supporting the container (12); and
a moving device (5) connected to the container support (3) and operative for generating movement of the container support (3) so that the contents of the container (12) can be mixed when the container support (3) is in a mixing position; wherein:
the container support (3) has a positioning device (11) designed to position the container (12) in a predetermined or predeterminable position on the container support (3), so that the removal side (17) of the container (12) is arranged substantially along a predetermined line (19) of the container support (3),
the container support (3) is mounted to be pivotable about a removal pivot axis (21) relative to the moving device (5) to move the container (12), which can be positioned on the container support (3), into a removal position,
the removal pivot axis (21) is arranged at a pivot axis angle of over 0° to 45° to the predetermined line (19) of the container support (3) so that the container (12) positioned on the container support (3) can be moved from the mixing position by means of a pivoting movement of the container support (3) about the removal pivot axis (21) into the removal position in which the removal side (17) is located on a lower side of the container (12) and also inclined toward a removal region (23) on the removal side (17) of the container (12).

US Pat. No. 10,428,298

METHANOL SLICING OF WINE

James Fred Salzman, Anna...

1. A method for reducing methanol content in a fermented solution, comprising:a. heating a fermented solution in a vacuum vessel to a fixed temperature, the fermented solution occupying a portion of the volume of the vessel;
b. lowering a boiling point of the solution by pulling a vacuum within the vessel to create a vapor; and
c. extracting the vapor, thereby producing a reduced methanol fermented solution without substantially reducing ethanol content.

US Pat. No. 10,428,297

WATER-SOLUBLE UNIT DOSE ARTICLES MADE FROM A COMBINATION OF DIFFERENT FILMS

MONOSOL, LLC, Merrillvil...

1. A water-soluble unit dose article comprising at least one sealed compartment, the water-soluble unit dose article comprisinga first water soluble film comprising a first water soluble resin;
and a second water soluble film comprising a second water soluble resin;
wherein the first film is sealed to the second film to form the at least one sealed compartment;
wherein the first water soluble resin comprises at least one polyvinyl alcohol homopolymer or at least one polyvinyl alcohol copolymer or a blend thereof, the at least one polyvinyl alcohol homopolymer or at least one polyvinyl alcohol copolymer or blend thereof having a 4% solution viscosity in demineralized water at 25° C. in a range of about 8 cP to about 40 cP, or about 12 cP to about 30 cP, or about 14 cP to about 25 cP;
wherein the second water soluble resin comprises at least one polyvinyl alcohol homopolymer or at least one polyvinyl alcohol copolymer or a blend thereof, the at least one polyvinyl alcohol homopolymer or at least one polyvinyl alcohol copolymer or blend thereof having a 4% solution viscosity in demineralized water at 25° C. in a range of about 4 cP to about 35 cP, or about 10 cP to about 20 cP, or about 10 cP to about 15 cP, or about 12 cP to about 14 cP; and
wherein the 4% solution viscosity in demineralized water at 25° C. of the at least one polyvinyl alcohol homopolymer or the at least one polyvinyl alcohol copolymer or the blend thereof of the first water soluble resin is greater than the 4% solution viscosity in demineralized water at 25° C. of the at least one polyvinyl alcohol homopolymer or the at least one polyvinyl alcohol copolymer or the blend thereof of the second water soluble resin and the difference between the 4% solution viscosity in demineralized water at 25° C. of the at least one polyvinyl alcohol homopolymer or the at least one polyvinyl alcohol copolymer or the blend thereof of the first water soluble resin and the 4% solution viscosity in demineralized water at 25° C. of the at least one polyvinyl alcohol homopolymer or the at least one polyvinyl alcohol copolymer or the blend thereof of the second water soluble resin is about 2 cP to about 20 cP, or about 3 cP to about 15 cP, or about 4 cP to about 12 cP;
provided that when the sealed compartment contains a fabric care or household care composition and a film comprises a blend of a polyvinyl alcohol homopolymer resin and an anionic polyvinyl alcohol copolymer resin, then both then first water soluble film and the second water soluble film comprise blends that include 65 wt. % or greater of an anionic polyvinyl alcohol copolymer resin, based on the total weight of polyvinyl alcohol resins in the blend; and
provided that when the sealed compartment contains a fabric care or household care composition and a film comprises a blend of at least two anionic polyvinyl alcohol copolymer resins, then both then first water soluble film and the second water soluble film comprise blends of at least two anionic polyvinyl alcohol copolymer resins.

US Pat. No. 10,428,287

SUBSEA FLUID PROCESSING SYSTEM

AKER SOLUTIONS AS, Lysak...

1. A subsea fluid processing system configured to receive a wellstream flow, the subsea fluid processing system comprising:a pressure control device configured to regulate a pressure of the wellstream flow;
a gas-liquid separator unit configured to receive the wellstream flow downstream of the pressure control device and to provide a liquid stream and a gas stream;
a first membrane separator configured to receive the gas stream and to provide a retentate stream and a permeate stream;
a compressor configured to receive the permeate stream and to provide a compressed permeate stream;
a discharge cooler configured to receive the compressed permeate stream and to provide a cooled compressed permeate stream for injection into a subsurface reservoir; and
a heat exchanger configured to transfer heat from the compressed permeate stream to the wellstream flow,
wherein, a density of the cooled compressed permeate stream is higher than a density of the compressed permeate stream.

US Pat. No. 10,428,277

DEVICE FOR PROCESSING SCRAP RUBBER

1. A rubber waste recycling device comprising:a reactor provided with a screw and disposed in a heating chamber, the reactor comprising two similar sections arranged in a horizontal plane and connected in parallel on a side surface;
a thermal decomposition assembly comprising screws with heating pipes installed along each screw's axis, the screws being arranged in each of the two similar sections of the reactor;
plates installed along a full length of each screw in parallel at the angles of an equilateral triangle, the plates being in contact and perpendicular to the side surface of each of the heating pipes;
a pipe coil installed inside each heating pipe, a cylindrical furnace directly connected to one end of each heating pipe and the other end of each heating pipe being connected to an inlet of the heating chamber, the cylindrical furnace being provided with an evaporator and a burner installed at an end of the furnace tangentially to a side surface of the furnace and perpendicularly to an axis of the furnace, each pipe coil's outlet being connected to the reactor;
a condenser having an outlet connected to a separator to separate liquids into hydrocarbons and water, a gas outlet of the condenser being connected to the heating pipes;
the evaporator having an inlet and an outlet, the outlet of the evaporator being connected to an inlet of the coil pipe and the inlet of the evaporator being connected to a water outlet of the separator;
a calorifer comprising a calorifer inlet, a calorifer outlet and a calorifer heating chamber, the calorifer outlet being connected to a flue gas stack, and inlet of the calorifer heating chamber being connected to atmosphere, an outlet of the calorifer heating chamber being connected to each of the heating pipe;
a cyclone filter having a filtering element of a heat-resistant carbon cloth bag with a shaker, and having a heating jacket having an inlet connected to the outlet of the heating chamber and an outlet of the heating jacket connected to the calorifer inlet, an outlet of the cyclone filter being connected to an inlet of the condenser;
a vapor-gas mixture extractor comprising two perforated pipes with a plugged inlet of each of the two perforated pipes, the two perforated pipes being arranged in an upper portion of the reactor, one perforated pipe in each of the two similar sections, outlets of the two perforated piped being connected to an inlet of the cyclone filter;
a solid residue discharge connected to an inlet of a magnetic separator, the magnetic separator having an outlet connected to an electrostatic separator.

US Pat. No. 10,428,273

LIQUID CRYSTAL COMPOUND HAVING BENZOPYRAN SKELETON, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition, containing at least one compound represented by formula (1) as component (a):
wherein, in formula (1),
R1 and R2 are independently hydrogen, alkyl having 1 to 16 carbons, alkenyl having 2 to 16 carbons, cyclopropyl, cyclobutyl or cyclopentyl, and in the alkyl and the alkenyl, at least one —CH2—is optionally replaced by —O—, —S—, —CO—, —COO—, —OCO—, —OCOO—, —C?C—, cyclopropane-1,2-diyl or —Si(CH3)2—, and in the groups, at least one hydrogen is optionally replaced by fluorine or chlorine, and in the groups, at least one —CH3 is optionally replaced by any one of monovalent groups (G1) to (G4) below;

wherein, in groups (G1) to (G4),
R3 is alkyl having 1 to 12 carbons or alkenyl having 2 to 12 carbons, and in the alkyl and the alkenyl, at least one —CH2 — is optionally replaced by —O—, and in the groups, at least one hydrogen is optionally replaced by fluorine or chlorine; and
in formula (1),
ring A1 and ring A2 are independently 1 ,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, decahydronaphthalene-2,6-diyl, tetrahydronaphthalene-2,6-diyl or naphthalene-2,6-diyl, and in the groups, one or two pieces of —CH2 — is optionally replaced by —O—, —S—, —CO—, —CF2—, —SiH2— or —Si(CH3)2—, and one or two pieces of —CH2CH2 — is optionally replaced by —CH?CH— or —CH?N—, and in the groups, at least one hydrogen on an aromatic ring is optionally replaced by halogen, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2, —OCH2F, or —C?N;
Z1 and Z2 are independently a single bond or alkylene having 1 to 4 carbons, and one —CH2— is optionally replaced by —O— or —CO—, and at least one —CH2CH2— is optionally replaced by —CH?CH— or —C?C—, and in the groups, at least one hydrogen is optionally replaced by fluorine or chlorine;
X, L1 and L2 are independently hydrogen or halogen;
Y is —CO— or —CF2—; and
a and b are independently 0, 1 or 2.

US Pat. No. 10,428,272

BARK AND WOOD FIBER GROWING MEDIUM

Profile Products, L.L.C.,...

21. A growing medium comprising:about 100 weight % fibrous pine wood components,
wherein the growing medium has a dry bulk density of 12.01 to 20.02 kg/m3 and wet bulk density of about 120 kg/m3 or lower.

US Pat. No. 10,428,270

HYBRID FLUORESCENT MATERIAL AND METHOD OF PRODUCING SAME

NICHIA CORPORATION, Anan...

1. A method of producing a hybrid fluorescent material comprising:dispersing Lu3Al5O12:Ce fluorescent material particles in a first solution;
mixing the first solution in a second solution, the second solution including a mixture of a first metallic salt containing at least one element selected from the group consisting of yttrium, gadolinium, and terbium, a second metallic salt containing aluminum and/or gallium, and a third metallic salt containing cerium,
wherein the mixing attaches (Y,Gd,Tb)3(Al,Ga)5O12:Ce fluorescent material precursor particles on surfaces of the Lu3Al5O12:Ce fluorescent material particles to obtain a hybrid fluorescent material precursor;
separating the hybrid fluorescent material precursor particles from the first and second solutions; and
calcining the hybrid fluorescent material precursor particles to obtain a hybrid fluorescent material of Lu3Al5O12:Ce fluorescent material particles covered by (Y,Gd,Tb)3(Al,Ga)5O12:Ce fluorescent material,
wherein the first solution contains ammonium hydrogen carbonate or ammonium carbonate.

US Pat. No. 10,428,261

RESIN COMPOSITE WITH OVERLOADED SOLIDS FOR WELL SEALING APPLICATIONS

CSI TECHNOLOGIES LLC, Ho...

1. A method of formulating a sealant to span an opening and form a seal with surfaces around the opening at a sealing location; comprising:selecting a fluid material capable of contacting and adhering to the surfaces around the opening and which reacts to form a solid material as a result of reaction thereof; and
selecting and intermixing at least one solid particulate material with the fluid material to form a composite;
locating the composite at the sealing location prior to the formation of the solid material, and wherein the at least one solid particulate material to move migrates within the composite to form a solids enhanced portion and a solids depleted portion of the composite at the sealing location;
wherein the solids enhanced portion has at least one of the following properties:
a thermal expansion factor of 45 or less;
an exothermic factor of 1.1 or less;
a heat flow factor of 5.5 or less;
a heat duration factor of 55 or less; and
a set time/cool down factor of 1.0 or less.

US Pat. No. 10,428,245

MOISTURE- AND HEAT-CROSSLINKABLE POLYURETHANE-BASED ADHESIVE COMPOSITION COMPRISING A LOW CONTENT OF ISOCYANATE MONOMER

BOSTIK SA, La Plaine St ...

1. A crosslinkable adhesive composition comprising:a) from 40 to 60 wt % of at least one polyurethane obtainable by a polyaddition reaction:
of at least one aromatic or aliphatic diisocyanate that is:
a1) isophorone diisocyanate,
a2) 2,4-toluene diisocyanate,
a3) diphenylmethane-2,4?-diisocyanate,
a4) an allophanate derivative of hexamethylene diisocyanate of formula (I):

in which:
p is an integer in the range from 1 to 2;
q is an integer in the range from 0 to 9;
R represents a hydrocarbon chain, saturated or unsaturated, cyclic or acyclic, linear or branched, comprising from 1 to 20 carbon atoms;
R3 represents a divalent alkylene group, linear or branched, having from 2 to 4 carbon atoms;
or a mixture of said aromatic or aliphatic diisocyanates,
with at least one polyether diol, with or without the presence of at least one reaction catalyst, at a reaction temperature T1 below 95° C., in anhydrous conditions, and in amounts of diisocyanate(s) and of polyether diol(s) leading to an NCO/OH molar ratio, designated r1, in the range from 1.6 to 1.9; said polyurethane having formula (II)
in which:R1 represents an aliphatic or aromatic divalent group:
a1?) a divalent group derived from isophorone diisocyanate:

a2?) a divalent group derived from 2,4-toluene diisocyanate:

a3?) a divalent group derived from diphenylmethane-2,4?-diisocyanate:
ora4?) a divalent group derived from an allophanate of hexamethylene diisocyanate (HDI) of formula (III):

in which:
p is an integer in the range from 1 to 2;
q is an integer in the range from 0 to 9;
R represents a hydrocarbon chain, saturated or unsaturated, cyclic or acyclic, linear or branched, comprising from 1 to 20 carbon atoms;
R3 represents a divalent alkylene group, linear or branched, having from 2 to 4 carbon atoms;
R2, which may be identical to or different from R3, represents a divalent alkylene group, linear or branched, having from 2 to 4 carbon atoms;
n is a non-zero integer such that the number-average molecular weight of the polyether block of formula [OR2]n— is in the range from 2000 to 12000 g/mol;
m is an integer such that the number-average molecular weight of the polyurethane is in the range from 3000 to 21000 g/mol;
b) from 39 to 59 wt % of at least one compatible tackifying resin, with a number-average molecular weight in the range from 200 Da to 5000 Da, and selected from the resins obtained by one of the following methods:
b1) polymerization of terpene hydrocarbons in the presence of Friedel-Crafts catalysts, followed by reaction with phenols,
b2) polymerization of alpha-methylstyrene, followed by reaction with phenols; and
c) from 0.01 to 1 wt % of at least one crosslinking catalyst, said percentages being expressed by weight relative to the total weight of the adhesive composition.

US Pat. No. 10,428,241

POLISHING COMPOSITIONS CONTAINING CHARGED ABRASIVE

Fujifilm Electronic Mater...

1. A polishing composition, comprisinga) a cationic abrasive comprising alumina, silica, titania, zirconia, a co-formed product thereof, or a mixture thereof, wherein the cationic abrasive comprises terminal groups of formula (I):
—Om—X—(CH2)n—Y  (I),in which m is an integer from 1 to 3; n is an integer from 1 to 10; X is Al, Si, Ti, or Zr; and Y is a cationic amino group or a cationic thiol group;b) an acid or base; and
c) water;
wherein the polishing composition has a pH of about 2 to about 7, is free of a cationic polymer, and is substantially free of a halide salt; and
wherein the polishing composition has a first rate of removal of silicon oxide, a second rate of removal of silicon nitride, and a ratio of the first rate to the second rate is at least about 2:1.

US Pat. No. 10,428,240

METHOD FOR PREPARING SLURRY COMPOSITION AND SLURRY COMPOSITION PREPARED THEREBY

KCTECH CO., LTD., Anseon...

1. A method of preparing a slurry composition, the method comprising:preparing a raw material slurry composition by mixing cerium oxide abrasive particles, a dispersant and water;
pulverizing the cerium oxide abrasive particles in the raw material slurry composition;
removing massive particles and agglomerated particles from the raw material slurry composition by putting the raw material slurry composition containing the pulverized cerium oxide abrasive particles into a separation device comprising a horizontal cylindrical rotating body and centrifuging the raw material slurry composition; and
obtaining a massive particles and agglomerated particles-removed slurry composition,
wherein a particle size ratio of the abrasive particles in the massive particles and agglomerated particles-removed slurry composition is 0.3 to 1.0 by Equation 1:
(B2?A2)/(B1?A1),  [Equation 1]
wherein A1 denotes D1 particle size before classification,
B1 denotes D99 particle size before classification,
A2 denotes D1 particle size after classification, and
B2 denotes D99 particle size after classification.

US Pat. No. 10,428,238

RESIN COMPOSITION, POLYIMIDE FILM AND METHOD FOR MANUFACTURING POLYIMIDE FILM

Zhen Ding Technology Co.,...

1. A method for manufacturing a polyimide film comprising:providing a resin composition, the resin composition comprising a modified polyimide compound, an epoxy resin, and a solvent, wherein the modified polyimide compound has a chemical structural formula of

 the Ar? represents diphenyl sulfone having a chemical structural formula of

 the modified polyimide compound has a degree of polymerization n of about 1 to about 50, the epoxy resin and the modified polyimide compound are in a molar ratio of about 0.1:1 to about 1:1;
coating the resin composition on a surface of a base, and heating the resin composition to cause the modified polyimide compound and the epoxy resin to undergo a polymerization reaction; and
drying the resin composition after the polymerization reaction and separating the dried resin composition from the base, thereby forming the polyimide film.

US Pat. No. 10,428,227

ANTISTATIC COMPOSITION FOR VEHICLE, VEHICLE, AND METHOD FOR MANUFACTURING VEHICLE

Nihon Tokushu Toryo Co., ...

1. An antistatic composition for a vehicle, consisting of a nickel powder and a polyolefin resin, which contains 2.5 to 15 vol. % of the nickel powder as a pigment volume concentration (vol. %),wherein the polyolefin is an acid-modified polyolefin or a chlorinated polyolefin.

US Pat. No. 10,428,222

SYSTEMS AND METHODS FOR CREATING DURABLE LUBRICIOUS SURFACES VIA INTERFACIAL MODIFICATION

LiquiGlide Inc., Cambrid...

1. An article, comprising:a substrate,
a liquid disposed on the substrate, the liquid having an average thickness and being immiscible with a contacting phase;
a first plurality of particles disposed in the liquid and having an average dimension between about 5 ?m and about 40 ?m and configured to remain in the liquid during use; and
a second plurality of particles disposed in the liquid and having an average dimension greater than about 20 ?m and greater than the average thickness of the liquid and configured to migrate to the contacting phase during use, wherein the first plurality of particles are hydrophobic and the second plurality of particles are hydrophilic.

US Pat. No. 10,428,219

DYE AND DYE COMPOSITION

SAMSUNG DISPLAY CO., LTD....

1. A dye comprising a compound represented by the following Chemical Formula 1:
wherein, in Chemical Formula 1,
R1, R4, R5, R8, R9, R12, R13, and R16 are each independently Br or Cl,
R2, R3, R6, R7, R10, R11, R14, and R15 are each independently any one of a group including Br, Cl, and a hydroxyl group, and a group including an —SH group, and
at least one of the R2, R3, R6, R7, R10, R11, R14, and R15 is any one of ethylene glycol, polyvinyl alcohol, and a group including an —SH group.

US Pat. No. 10,428,215

RESIN COMPOSITIONS FOR INTAKE HOSES OF TURBO ENGINES WITH ENHANCED THERMAL RESISTANCE

Hyundai Motor Company, S...

1. A resin composition for intake hoses comprising:20 to 40% by weight of a polyamide resin;
10 to 30% by weight of a polypropylene resin;
30 to 50% by weight of a polyester elastomer;
0.1 to 0.5% by weight of an antioxidant;
1 to 3% by weight of a heat stabilizer;
0.2 to 0.5% by weight of a lubricant; and
1 to 2% by weight of a master batch.

US Pat. No. 10,428,206

PROCESS FOR THE CONTINUOUS SYNTHESIS OF A MODIFIED DIENE ELASTOMER

COMPAGNIE GENERALE DES ET...

1. A process for the continuous synthesis of a modified diene elastomer comprising at least one silicon atom directly connected to the elastomer chain, comprising:a) a stage of polymerization by means of n reactors r1 to rn which are equipped with an internal stirring system, which are assumed perfectly stirred and which are arranged in series, n varying from 2 to 15, the reactor r1 being fed by an input solution comprising a solvent, one or more monomers, an anionic polymerization initiator and a polar agent, one or more of the reactors r2 to rn additionally being fed by reinjection of a purified solution comprising solvent and/or monomer(s), the purity of the or of each reinjected solution being such that the proportion of the number of dead chains in the output stream from the reactor rn is less than 30%, of the number of living chains initiated in the reactor r1, the temperature of each reactor varying from 20° C. to 150° C., and being greater than or equal to the temperature of the reactor which immediately precedes it, the temperature of the reactor rn being greater than the temperature of the reactor r1,
the amount by weight W1 of monomer(s) introduced into the reactor r1 being such that:

the amount by weight Wi? of monomer(s) reinjected into the reactor ri?, when Wi??0, i? varying from 2 to n, being such that:

and such that Wi? represents from 5% to 100% by weight of the weight of the solution reinjected into the reactor ri?, when Wi? 0,
where Wi is the amount by weight of monomer(s) introduced into the reactor ri, i varying from 1 to n,
the amount by weight of all of the monomers entering the reactors r1 to rn representing from 5% to 25% by weight of the sum of the total inputs by weight of the reactors r1 to rn,
the overall conversion by weight Ci? in each reactor ri? being such that:

where Pi? is the weight of polymer formed at the outlet of the reactor ri?, i? varying from 1 to n?1, and
Cn is the overall conversion by weight in the reactor rn, with

where Pn is the weight of polymer formed at the outlet of the reactor rn,
b) a stage of modification of the living diene elastomer obtained in the preceding stage and exhibiting a polydispersity index varying from 1.1 to 2 by means of at least one functionalization, coupling or star-branching agent, which makes it possible to introduce, into the elastomer, a functional group comprising at least one silicon atom directly connected to the elastomer chain.

US Pat. No. 10,428,195

POLYMERIC MATERIAL FOR AN INSULATED CONTAINER

Berry Plastics Corporatio...

1. An insulative material comprising a first polymer material, a second polymer material, a chemical blowing agent, and a nucleating agent, whereinthe second polymer material is at least about 15 wt % of the insulative material
the chemical blowing agent is up to about 2 wt % of the insulative material,
the nucleating agent is up to about 2 wt % of the insulative material, and
wherein the insulative material is non-aromatic and has a density of about 0.01 g/cm3 to about 0.19 g/cm3, and
wherein the first polymer material comprises a polypropylene homopolymer,
wherein the second polymer material comprises a polypropylene homopolymer.

US Pat. No. 10,428,185

THERMOPLASTIC ELASTOMER HYDROGELS

Colorado State University...

1. A block copolymer hydrogel, comprising:a glass formed from a dry blend comprising polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS; and
a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO—SOS by weight, the liquid medium comprising at least one room-temperature ionic liquid (RTIL);
the block copolymer hydrogel having a fatigue resistance to at least 500,000 compression cycles, wherein the compression cycles operate with at least 12% compression at a frequency of about 1 Hz, and the compression cycles operate with at least 50% compression at least every eleventh cycle and wherein the fatigue resistance is characterized by a modulus recoverable to at least 80% of its value before the compression cycles were run.

US Pat. No. 10,428,184

METHOD FOR PRODUCING A SUPERHYDROPHOBIC MEMBRANE OR SURFACE COATING OF A SUBSTRATE

Universitaet Bayreuth, B...

1. Method for producing a superhydrophobic membrane or surface coating of a substrate from an aqueous phase comprising the following steps:a) Preparing an aqueous dispersion by dispersing particles of hydrophobic polymer(s) in an aqueous solution of protic polymer(s), wherein the protic polymer(s) and the hydrophobic polymer(s) are present in a weight ratio of protic polymer(s):hydrophobic polymer(s) in a range of 5:95 to 22:78,
b) electrospinning the dispersion of step a) onto a carrier for producing the membrane or onto the surface for producing the surface coating thereby producing at least one fiber and a nonwoven fabric from the fiber,
c) subjecting the nonwoven fabric to a sol-gel process, wherein a precursor/precursors of the sol-gel comprise(s) an alkoxysilane, and
d) curing the nonwoven fabric obtained by step c) at a temperature in a range of 50° C. to 150° C.

US Pat. No. 10,428,181

POROUS CROSS-LINKED PARTIALLY ALIPHATIC POLYIMIDE NETWORKS

OHIO AEROSPACE INSTITUTE,...

1. A porous cross-linked partially aliphatic polyimide network comprising a polyamic acid oligomer that (i) comprises a repeating unit of a dianhydride and a diamine and terminal functional groups, (ii) has an average degree of polymerization of 10 to 70, (iii) has been cross-linked via a cross-linking agent, comprising three or more cross-linking groups, at a balanced stoichiometry of the cross-linking groups to the terminal functional groups, and (iv) has been chemically imidized to yield the porous cross-linked polyimide network, wherein the polyimide network is partially aliphatic based on one or both of the following:(a) the diamine comprises: (i) a first diamine at 5 to 95% (mol %) and (ii) a second diamine at 5 to 95% (mol %), wherein (1) the first diamine comprises a first diamine linear aliphatic backbone chain comprising carbon atoms and optionally one or more oxygen atoms therein, extending a length of 3 to 30 atoms, and having a ratio of carbon:oxygen of 2:1 to 3:0, and (2) the second diamine does not comprise any linear aliphatic backbone chain extending a length of 3 or more atoms; or
(b) the dianhydride comprises: (i) a first dianhydride at 5 to 95% (mol %) and (ii) a second dianhydride at 5 to 95% (mol %), wherein (1) the first dianhydride comprises a first dianhydride linear aliphatic backbone chain comprising carbon atoms and optionally one or more oxygen atoms therein, extending a length of 3 to 30 atoms, and having a ratio of carbon:oxygen of 2:1 to 3:0, and (2) the second dianhydride does not comprise any linear aliphatic backbone chain extending a length of 3 or more atoms.

US Pat. No. 10,428,177

WATER ABSORBING OR WATER SOLUBLE POLYMERS, INTERMEDIATE COMPOUNDS, AND METHODS THEREOF

Sirrus, Inc., Loveland, ...

1. A grafted polymer comprising:i. a first component including a polymer formed by polymerizing the alkene groups of one or more monomers including a 1,1-diester-1-alkene compound, attached to;
ii. a second component that is a hydrophilic component, wherein the hydrophilic component includes a cation or a water-soluble polymer;
wherein the grafted polymer has a network structure.

US Pat. No. 10,428,164

PRINTING MATERIAL FOR THREE-DIMENSIONAL PRINTING APPARATUS

XYZprinting, Inc., New T...

1. A printing material for a three-dimensional printing apparatus, comprising:a wire comprising a core and a shell;
wherein a Shore hardness of the core is A45-A90;
the shell covers the core, wherein a Shore hardness of the shell is D40-D85, and the Shore hardness of the shell is higher than the Shore hardness of the core;
a volume percentage of the shell is 10% to 30%, and a volume percentage of the core is 70% to 90%,
wherein the wire has a diameter of 1.7 mm to 3.1 mm.

US Pat. No. 10,428,160

COLORIMETRIC HYDROGEL BASED NANOSENSOR FOR DETECTION OF THERAPEUTIC LEVELS OF IONIZING RADIATION

ARIZONA BOARD OF REGENTS ...

6. An apparatus comprising:a substantially colorless hydrogel to receive a low dose of radiation and form a radiated hydrogel having a color; and
a detector optically coupled to the radiated hydrogel, wherein the radiated hydrogel comprises a plasmonic nanoparticle.

US Pat. No. 10,428,138

ANTIBODY AND ANTIBODY-CONTAINING COMPOSITION

Ostrich Pharma KK, Kyoto...

1. A lotion, comprising:ostrich antibodies which specifically bind to a surface protein of a virus, wherein the virus comprises any one of HPV type 6, 11, 16 or 18; and
water, glycerol, ethanol, sodium polyacrylate, hydroxyethyl cellulose, phenoxyethanol, EDTA-2Na, paraben, polysorbate 80, and fatty acid sorbitan.

US Pat. No. 10,428,132

TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND VARIANT, AS WELL AS A PREPARATION METHOD AND USE THEREOF

WEST CHINA HOSPITAL, SICH...

1. A tumor necrosis factor-related apoptosis-inducing ligand variant, characterized in that the variant is a fusion protein of a tumor necrosis factor-related apoptosis-inducing ligand and an F3 peptide, and the F3 peptide is fused to the N-terminus or C-terminus of the tumor necrosis factor-related apoptosis-inducing ligand by a linker.

US Pat. No. 10,428,122

TUBERCULOSIS COMPOSITIONS AND METHODS OF TREATING OR PREVENTING TUBERCULOSIS

International AIDS Vaccin...

1. A fusion protein comprising at least four or five Mycobacterium tuberculosis (Mtb) antigens, wherein the Mtb antigens are chosen from Rv1009, Rv3136, Rv3615c, Rv2628, Rv2034, and Rv3136 N-terminus, and wherein the fusion protein is chosen from:Rv1009-Rv2628-Rv3615c-Rv3136;
Rv1009-Rv2034-Rv2628-Rv3615c-Rv3136;
Rv1009-Rv3615c-Rv2034-Rv2628;
Rv3615c-Rv2034-Rv2628-Rv1009;
Rv2034-Rv3615c-Rv2628-Rv3136;
Rv3136-Rv2628-Rv3615c-Rv2034;
Rv1009-Rv3136Nt-Rv2628-Rv2034-Rv3615c;
Rv2034-Rv3615c-Rv3136Nt-Rv2628-Rv1009;
Rv3615c-Rv2628-Rv1009-Rv3136Nt-Rv2034;
Rv1009-Rv2628-Rv3136Nt-Rv2034-Rv3615c;
Rv2628-Rv3136Nt-Rv1009-Rv2034-Rv3615c; and
Rv2628-Rv3136Nt-Rv2034-Rv3615c-Rv1009.

US Pat. No. 10,428,112

MULTIPLEXED SAME TYPE-ANTIGENIC PEPTIDE

RIKEN, Wako-shi, Saitama...

1. A multiplexed same type-antigenic peptide comprising a dendritic core and B-cell recognition peptides, wherein the multiplexed same type-antigenic peptide comprises 4 to 8 B-cell recognition peptides of the same type, which are bound to the terminal ends of the dendritic core directly or via a spacer, and production of a class-switched antibody is induced by directly stimulating B cells in vivo in the absence of a T cell epitope; wherein the dendritic core has the following structure:

US Pat. No. 10,428,109

PROCESS FOR THE PREPARATION OF 1,5-BENZOTHIAZEPINE COMPOUNDS

1. A process for the preparation of a compound of formula (I):
comprising reacting a compound of formula (II):

with a compound of formula (III):

wherein
R6 is a suitable protecting group;
to obtain a compound of formula (IV):

and deprotecting said compound of formula (IV) to obtain the compound of formula (I).

US Pat. No. 10,428,108

DIFLUOROKETAMIDE DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A compound of formula (I)
wherein:
R1 is alkyl, optionally substituted cycloalkyl, haloalkyl, optionally substituted heterocycloalkylalkyl optionally substituted arylalkyl or optionally substituted heteroarylalkyl, wherein each moiety is optionally substituted by one to three substituents independently selected from halogen, alkyl, haloalkyl, cycloalkyl, cyano, hydroxyl, alkoxy, haloalkoxy or phenyl;
R2, R3 R4, R6, R7 and R9 are independently selected from hydrogen, alkyl or cycloalkyl;
R5 is optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl, wherein each moiety is optionally substituted by one to three substituents independently selected from halogen, alkyl, haloalkyl, cycloalkyl, cyano, hydroxyl, alkoxy, haloalkoxy or phenyl;
R8 is optionally substituted adamantylalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted dicycloalkylalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted arylalkenyl, optionally substituted diarylalkyl, optionally substituted aryloxyalkyl, optionally substituted diaryloxyalkyl, optionally substituted arylaryloxyalkyl, optionally substituted heteroarylaryloxyalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted arylheteroarylalkyl, optionally substituted arylheteroaryloxyalkyl or optionally substituted aryloxyheteroarylalkyl, wherein each moiety is optionally substituted by one to three substituents independently from selected halogen, alkyl, haloalkyl, cycloalkyl, cyano, hydroxyl, alkoxy, haloalkoxy or phenyl;
wherein a heterocycloalkyl moiety is a ring system of 4 to 9 ring atoms, comprising 1, 2, or 3 ring heteroatoms selected from N, O and S, the remaining ring atoms being carbon, heteroaryl moiety is a ring system of 5 or ring atoms, comprising 1, 2, 3 or 4 heteroatoms selected from N, O and S; the remaining ring atoms being carbon and an aryl moiety is a monovalent aromatic carbocyclic mono- or bicyclic ring system comprising 6 to 10 carbon ring atoms;
or, a pharmaceutically acceptable salt thereof.

US Pat. No. 10,428,106

PHOSPHATE REPLACEMENT MRNA CAP ANALOGS

ModernaTX, Inc., Cambrid...

1. An RNA molecule having a 5? end comprising a compound of formula (III):
wherein
indicates the attachment point of the 5? end to the RNA molecule;B1 is
whereinindicates the attachment point of B1 to the compound;Ra, Rb, and Rc are H;
R1 is CH3;
B2 is
whereinindicates the attachment point of B2 to the compound;Rd, Re, and Rf are H;
X1 is N or N+(CH3);
X2 is O;
R20, R21, R22, and R23 are H;
R27 and R28 are OH;
R2 is OR3;
R3 is H or CH3; and
Y2 is
whereinindicates the attachment points of Y2 to the compound.

US Pat. No. 10,428,105

ALKYNYL NUCLEOSIDE ANALOGS AS INHIBITORS OF HUMAN RHINOVIRUS

Novartis AG, Basel (CH)

1. The compound:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,428,103

LABELLED NUCLEOTIDES

Illumina Cambridge Limite...

1. A nucleoside or nucleotide comprising a base attached to a detectable label via a phosphine-cleavable linker comprising a disulfide, wherein the nucleoside or nucleotide comprises a ribose or deoxyribose moiety with a hydroxyl protecting group attached to the 2? or 3? oxygen atom, and wherein the protecting group is azidomethyl.

US Pat. No. 10,428,102

GLYCOLIPIDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR USE IN THERAPY

THE UNIVERSITY OF NOTTING...

1. A compound of Formula Ie:or a pharmaceutically acceptable salt thereof, for use in medicine,wherein:
R1 a carbohydrate group;
R2 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group;
R3 is selected from hydrogen, a C1-C24 alkyl or a C1-C24 derivative of an alkyl group, a C2-C24 alkenyl or a C2-C24 derivative of an alkenyl group, and a C2-C24 alkynyl group or a C2-C24 derivative of an alkynyl group;
X is either absent or is -O-, -NRa-, -S- or -CRaRb-, wherein Ra and Rb are independently selected from the group consisting of hydrogen and C1-C4 alkyl; and
n is an integer from 1 to 6;
wherein said derivative of alkyl, alkenyl or alkynyl group is composed of said alkyl, alkenyl or alkynyl group wherein one or more of the hydrogen atoms in the hydrocarbon chain of said derivative are replaced with substituent groups selected from hydroxyl, amino, carboxyl, aryl, or heteroaryl groups

US Pat. No. 10,428,099

PHARMACEUTICAL CO-CRYSTAL COMPOSITION AND USE THEREOF

SYN-NAT PRODUCTS ENTERPRI...

1. A co-crystal comprising a platinum analogue and a diacid,wherein the platinum analogue is selected from the group consisting of:
andthe diacid is selected from the group consisting of:

provided that when the platinum analogue is carboplatin (Pt-01), the diacid is not CF-01, CF-04, CF-10A, CF-10B, CF-10C, or CF-10D.

US Pat. No. 10,428,095

COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS

Achillion Pharmaceuticals...

1. A compound of structureor a pharmaceutically acceptable salt thereof.

US Pat. No. 10,428,087

PYRIMIDINONES AS PI3K INHIBITORS

Incyte Corporation, Wilm...

1. A compound of Formula If:or pharmaceutically acceptable salt thereof, wherein:A is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)ORa, NRcC(O)NRcRd, C(?NRe)Rb, C(?NRe)NRcRd, NRcC(?NRe)NRcRd, NRcS(O)Rb, NRcS(O)2Rb, NRcS(O)2NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb, and S(O)2NRcRd; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, or heterocycloalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, C(?NRe)NRcRd, NRcC(?NRe)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)ORa, NRcC(O)NRcRd, NRcS(O)Rb, NRcS(O)2Rb, NRcS(O)2NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb, and S(O)2NRcRd;
R1 is ORA, SRA, S(O)RA, S(O)2RA, NRARB, NRcC(O)NRARB, NRCC(O)ORA, NRCC(?NRE)NRARB, NRCS(O)2RA, NRCS(O)2NRCRA, heterocycloalkyl, or heteroaryl, wherein said heterocycloalkyl or heteroaryl is optionally substituted with 1, 2, or 3 substituents independently selected from —(C1-4 alkyl)r-Cy1, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, C(?NRe)NRc1Rd1, NRc1C(?NRe)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, and S(O)2NRc1Rd1;
R2a is H, halo, OH, CN, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl, wherein said C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, C(?NRe)NRc2Rd2, NRc2C(?NRe)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc2Rd2;
R3, R4, R5, and R6 are independently selected from H, halo, CN, NO2, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, NRc3Rd3, NRc3C(O)Rb3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3, S(O)2NRc3Rd3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)NRc3Rd3, NRc3C(O)ORa3, C(?NRe)NRc3Rd3, NRc3C(?NRe)NRc3Rd3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3, and S(O)2NRc3Rd3;
RA is heteroaryl, heterocycloalkyl, heteroarylalkyl, or heterocycloalkylalkyl, each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from —(C1-4 alkyl)r-Cy1, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, C(?NRe)NRc1Rd1, NRc1C(?NRe)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, and S(O)2NRc1Rd1;
RB and RC are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(?NRf)NRc5Rd5, NRc5C(?NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, and S(O)2NRc5Rd5;
RE is H, CN, NO2, ORa5, SRb5, S(O)2Rb5, C(O)Rb5, S(O)2NRc5Rd5, or C(O)NRc5Rd5;
Cy1 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, each optionally substituted by 1, 2, 3, 4, or 5 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, C(?NRe)NRc1Rd1, NRc1C(?NRe)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, and S(O)2NRc1Rd1;
Ra, Rb, Rc, and Rd are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(?NRf)NRc5Rd5, NRc5C(?NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, and S(O)2NRc5Rd5;
or Rc and Rd together with the N atom to which they are attached form a 3-, 4-, 5-, 6-, or 7-membered heterocycloalkyl group or a heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(?NRf)NRc5Rd5, NRc5C(?NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, and S(O)2NRc5Rd5;
Ra1, Rb1, Rc1, and Rd1 are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(?NRf)NRc5Rd5, NRc5C(?NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, and S(O)2NRc5Rd5;
or Rc1 and Rd1 together with the N atom to which they are attached form a 3-, 4-, 5-, 6-, or 7-membered heterocycloalkyl group or a heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(?NRf)NRc5Rd5, NRc5C(?NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, and S(O)2NRc5Rd5;
Ra2, Rb2, Rc2, and Rd2 are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(?NRf)NRc5Rd5, NRc5C(?NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, and S(O)2NRc5Rd5;
or Rc2 and Rd2 together with the N atom to which they are attached form a 3-, 4-, 5-, 6-, or 7-membered heterocycloalkyl group or a heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(?NRf)NRc5Rd5, NRc5C(?NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, and S(O)2NRc5Rd5;
Ra3, Rb3, Rc3, and Rd3 are independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(?NRf)NRc5Rd5, NRc5C(?NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, and S(O)2NRc5Rd5;
or Rc3 and Rd3 together with the N atom to which they are attached form a 3-, 4-, 5-, 6-, or 7-membered heterocycloalkyl group or a heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, halo, C1-6 haloalkyl, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRa5C(O)Rb5, NRc5C(O)NRc5Rd5, NRc5C(O)ORa5, C(?NRf)NRc5Rd5, NRc5C(?NRf)NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, and S(O)2NRc5Rd5;
Re and Rf are independently selected from H, CN, NO2, ORa5, SRb5, S(O)2Rb5, C(O)Rb5, S(O)2NRc5Rd5, and C(O)NRc5Rd5;
Ra5, Rb5, Rc5, and Rd5 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, wherein said C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, or heterocycloalkylalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, di(C1-6 alkyl)amino, C1-6 haloalkyl, and C1-6 haloalkoxy;
or Rc5 and Rd5 together with the N atom to which they are attached form a 3-, 4-, 5-, 6-, or 7-membered heterocycloalkyl group or heteroaryl group, each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylamino, di(C1-6 alkyl)amino, C1-6 haloalkyl, and C1-6 haloalkoxy; and
r is 0 or 1;
provided that:
a) when A is 3-fluorophenyl; R2a is H; R3 is methyl; and R4, R5, and R6 are H; then, R1 is other than 4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl; and
b) when A is 1,3-dioxolan-2-yl; R2a, R3, R4, and R6 are H; then, R1 is other than 1-(tert-butoxycarbonyl)piperidin-4-yl.

US Pat. No. 10,428,083

HETEROCYCLYLMETHYL-THIENOURACILE AS ANTAGONISTS OF THE ADENOSINE-A2B-RECEPTOR

BAYER PHARMA AKTIENGESELL...

1. Compound of the formula (I)
in which
the ring A is an azaheterocycle of the formula

in which * marks the bond to the adjoining CH(R1) group,
R5 is hydrogen, (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy, amino, (C1-C5)-alkanoylamino or (C1-C4)-alkoxycarbonylamino,
R6 is hydrogen, methyl or ethyl,
R7A and R7B are the same or different and are independently hydrogen or (C1-C4)-alkyl,
R8 is hydrogen, (C1-C4)-alkyl, (C2-C4)-alkenyl, (C1-C5)-alkanoyl or (C1-C4)-alkoxycarbonyl,
where (C1-C4)-alkyl may be up to disubstituted by hydroxyl,
R9A and R9B are the same or different and are independently hydrogen or (C1-C4)-alkyl
and
X is O, N(R10) or S, in which
R10 is hydrogen, cyano or (C1-C4)-alkoxycarbonyl,
R1 is hydrogen or methyl,
R2 is hydrogen, methyl or ethyl, where methyl and ethyl may be up to trisubstituted by fluorine,
R3 is (C2-C6)-alkyl, (C2-C6)-alkenyl or (C2-C6)-alkynyl,
where (C2-C6)-alkyl may be substituted by a radical selected from the group of hydroxyl, methoxy, ethoxy, trifluoromethoxy, cyclopropyl, cyclobutyl, oxetanyl and phenyl, and up to trisubstituted by fluorine,
and
(C2-C6)-alkenyl may be up to trisubstituted by fluorine,
where the cyclopropyl and cyclobutyl groups mentioned may in turn be up to disubstituted, identically or differently, by a radical selected from fluorine and methyl,
or
R3 is a group of the formula —CH2—R14 in which
R14 is cyclopropyl, cyclobutyl, oxetanyl or tetrahydrofuranyl, where cyclopropyl, cyclobutyl and oxetanyl may be up to disubstituted, identically or differently, by a radical selected from fluorine and methyl,
and
R4 is (C1-C6)-alkyl or (C2-C6)-alkenyl,
where (C1-C6)-alkyl may be up to pentasubstituted and (C2-C6)-alkenyl up to trisubstituted by fluorine
and
where one CH2 group in (C1-C6)-alkyl may be exchanged for —O—, —S— or —S(O)2—, with the proviso that there are at least two carbon atoms between such a heteroatom and the uracil N1 atom,
or
R4 is a group of the formula —(CH2)m—CN, —(CH2)n—R11 or —(CH2)p—R12, in which
m is the number 1, 2, 3 or 4,
n is the number 2 or 3,
p is the number 1 or 2,
R11 is dimethylamino, diethylamino or azetidino
and
R12 is (C3-C6)-cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl or 5-membered azaheteroaryl,
where (C3-C6)-cycloalkyl may be up to disubstituted, identically or differently, by a radical selected from fluorine and methyl
and
azaheteroaryl may be up to disubstituted, identically or differently, by a radical selected from methyl and trifluoromethyl,
or
R4 is a group of the formula —(CH2)2—O—R13 in which
R13 is (C3-C6)-cycloalkyl,
and a salt, a solvate, and a solvate of the salt thereof.

US Pat. No. 10,428,082

TRIAZOLE DERIVATIVES OF MELAMPOMAGNOLIDE B AND METHODS OF USE THEREOF

BioVentures, LLC, Little...

1. A compound of Formula (II):
wherein:
R1, R2, R3, R4, and R5 are each independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heteroaryl, substituted heteroaryl, methyl, trifluoromethyl, halogen, cyano, nitro, amidine, amino, carboxyl, ester, alkylalkylamino, dialkylamino, hydroxyl, alkoxy or arylalkoxy (e.g. methoxy, ethoxy, benzyloxy, substituted benzyloxy) and combinations thereof; and R1 and R2 or R2 and R3 or R3 and R4 or R4 and R5 together can optionally form an optionally substituted cycloalkyl, aryl or heteroaryl 5 or 6 membered ring.

US Pat. No. 10,428,081

EGFR INHIBITOR, PREPARATION METHOD AND USE THEREOF

SHANGHAI HANSOH BIOMEDICA...

1. A compound selected from the group consisting of a compound of formula (IIIA1-7), a compound of formula (IIIA1-8), a compound of formula (IIIA1-9), a compound of formula (IVA1-4), a compound of formula (IVA-5), a compound of formula (IVA1-6), and a compound of formula (IVA1-7), or a stereoisomer or a pharmaceutically acceptable salt thereof:
wherein
R is selected from the group consisting of hydrogen and bis-C1-8 alkylaminomethyl;
R1 is selected from the group consisting of:

wherein the three R6 in
are optionally the same or different substituents;R2 is selected from the group consisting of C1-8 alkyl and C3-8 cycloalkyl, wherein the C1-8 alkyl and C3-8 cycloalkyl are each optionally substituted by one or more groups selected from the group consisting of halogen, hydroxy, C1-8 alkyl, C1-8 alkoxy, haloC1-8 alkoxy, C3-8 cycloalkyl and C3-8 cycloalkoxy;
R3 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, C1-8 alkyl, C1-8 alkoxy, C3-8 cycloalkyl, trifluoromethyl, trifluoromethoxy, SO2R9, C(O)R10, C(O)OR10 and P(O)R11R12;
each R4 is independently selected from the group consisting of hydrogen, deuterium, halogen, hydroxy, sulfhydryl, cyano, nitro, azido, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, 3- to 8-membered heterocyclyloxy, 3- to 8-membered heterocyclylthio, C5-10 aryl, C5-10 aryloxy, C5-10 arylthio, 5- to 10-membered heteroaryl, 5- to 10-membered heteroaryloxy, 5- to 10-membered heteroarylthio, —C0-8—P(O)R11R12, —C0-8—S(O)rR9, —C0-8—O—R10, —C0-8—C(O)R10, —C0-8—C(O)OR10, —C0-8—O—C(O)R10, —C0-8—NR7R8, —C0-8—C(O)NR7R8, —N(R7)—C(O)R10 and —N(R7)—C(O)OR10;
wherein the C1-8 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C5-10 aryl, 5- to 10-membered heteroaryl, 5- to 7-membered carbocycle, 5- to 7-membered heterocycle, C5-7 aryl and 5- to 7-membered heteroaryl are each optionally substituted by one or more groups selected from the group consisting of halogen, hydroxy, sulfhydryl, cyano, nitro, azido, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, 3- to 8-membered heterocyclyloxy, 3- to 8-membered heterocyclylthio, C5-10 aryl, C5-10 aryloxy, C5-10 arylthio, 5- to 10-membered heteroaryl, 5- to 10-membered heteroaryloxy, 5- to 10-membered heteroarylthio, —C0-8—S(O)rR9, —C0-8—O—R10, —C0-8—C(O)R10, —C0-8—C(O)OR10, —C0-8—O—C(O)R10, —C0-8—NR7R8, —C0-8—C(O)NR7R8, —N(R7)—C(O)R10 and —N(R7)—C(O)OR10;
R6 is selected from the group consisting of hydrogen, deuterium, C1-8 alkyl, haloC1-8 alkyl and C(O)R10;
R7 is selected from the group consisting of hydrogen, deuterium, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C5-10 aryl, 5- to 10-membered heteroaryl, —C0-8—S(O)rR9, —C0-8—O—R10, —C0-8—C(O)R10, —C0-8—C(O)OR10, —C0-8—O—C(O)R10, —C0-8—NR7R8 and —C0-8—C(O)NR7R8,
wherein the C1-8 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C5-10 aryl and 5- to 10-membered heteroaryl are each optionally substituted by one or more groups selected from the group consisting of halogen, hydroxy, sulfhydryl, cyano, nitro, azido, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, 3- to 8-membered heterocyclyloxy, 3- to 8-membered heterocyclylthio, C5-10 aryl, C5-10 aryloxy, C5-10 arylthio, 5- to 10-membered heteroaryl, 5- to 10-membered heteroaryloxy, 5- to 10-membered heteroarylthio, —C0-8—S(O)rR9, —C0-8—O—R10, —C0-8—C(O)R10, —C0-8—C(O)OR10, —C0-8—O—C(O)R10, —C0-8—NR7R8, —C0-8—C(O)NR7R8, —N(R7)—C(O)R10 and —N(R7)—C(O)OR10;
R8 is selected from the group consisting of hydrogen, deuterium, halogen, hydroxy, sulfhydryl, cyano, nitro, azido, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, 3- to 8-membered heterocyclyloxy, 3- to 8-membered heterocyclylthio, C5-10 aryl, C5-10 aryloxy, C5-10 arylthio, 5- to 10-membered heteroaryl, 5- to 10-membered heteroaryloxy, 5- to 10-membered heteroarylthio, —C0-8—S(O)rR9, —C0-8—O—R10, —C0-8—C(O)R10, —C0-8—C(O)OR10, —C0-8—O—C(O)R10, —C0-8—NR7R8, —C0-8—C(O)NR7R8, —N(R7)—C(O)R10 and —N(R7)—C(O)OR10,
wherein the C1-8 alkyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, C5-10 aryl and 5- to 10-membered heteroaryl are each optionally substituted by one or more groups selected from the group consisting of halogen, hydroxy, sulfhydryl, cyano, nitro, azido, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, 3- to 8-membered heterocyclyl, 3- to 8-membered heterocyclyloxy, 3- to 8-membered heterocyclylthio, C5-10 aryl, C5-10 aryloxy, C5-10 arylthio, 5- to 10-membered heteroaryl, 5- to 10-membered heteroaryloxy, 5- to 10-membered heteroarylthio, —C0-8—S(O)rR9, —C0-8—O—R10, —C0-8—C(O)R10, —C0-8—C(O)OR10, —C0-8—O—C(O)R10, —C0-8—NR7R8, —C0-8—C(O)NR7R8, —N(R7)—C(O)R10 and —N(R7)—C(O)OR10;
R9 is selected from the group consisting of hydrogen, deuterium, C1-8 alkyl, C3-8 cycloalkyl, haloC1-8 alkyl, bis-C1-8 alkylamino, phenyl and p-methylphenyl;
R10, R11 and R12 are each independently selected from the group consisting of hydrogen, deuterium, C1-8 alkyl, C3-8 cycloalkyl, haloC1-8 alkyl and hydroxyC1-8 alkyl,
provided that when the compound is a compound of formula (IIIA1-9), each R10 is independently selected from the group consisting of hydrogen, deuterium, C3-8 cycloalkyl, haloC1-8 alkyl and hydroxy C1-8 alkyl;
m is 0, 1, 2, 3 or 4;
r is 0, 1 or 2;
q is 0, 1, 2, 3 or 4; and
“” means that substituent R can have a Z or E configuration.

US Pat. No. 10,428,073

SALT TYPE AND CRYSTAL TYPE OF 4H-PYRAZOLO [1, 5-ALPHA] BENZIMIDAZOLE COMPOUND AND PREPARATION METHOD AND INTERMEDIATE THEREOF

Hubei Bio-Pharmaceutical ...

5. Crystal type A of compound 3, characterized by an XRPD pattern as shown in FIG. 1,

US Pat. No. 10,428,071

CARBOLINE DERIVATIVE SERVING AS BROMODOMAIN INHIBITOR

NINGBO WENDA PHARMA TECHN...

1. A carboline derivative selected from the group consisting ofor a salt thereof.

US Pat. No. 10,428,067

COMPOUNDS AND METHODS FOR KINASE MODULATION

Plexxikon Inc., Berkeley...

1. A compound having Formula I:or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer, or a deuterated analog thereof, wherein:A is N or —C(Z3)?;
W is —C(R2)? or N;
Z3 is hydrogen or halo;
Z2 is:

L is —SO2—NR6R7, —NHC(O)R4, or —C(O)NR3R4;
R1 is C1-6alkyl, halo, or halo-C1-6alkyl;
R2 is hydrogen, —CH3, —CH2F, —CHF2, —CF3, or halo;
R3 is hydrogen or C1-6alkyl;
R4 is C3-6cycloalkyl, C3-6cycloalkyl-C1-3alkylene, cyano-C3-6 cycloalkyl, cyano-C3-6 cycloalkyl-C1-3alkylene, cyano-C1-6alkylene, heterocycloalkyl, heteroaryl, or —(CH2)—[(CR10)]2-OH, wherein the C3-6cycloalkyl, C3-6cycloalkyl-C1-3alkylene, cyano-C3-6 cycloalkyl, cyano-C3-6 cycloalkyl-C1-3alkyl, cyano-C1-6alkylene, heterocycloalkyl, and heteroaryl are optionally substituted with 1-2 G groups;
or R3 and R4, together with the N atom to which they are attached, join to form a 4-6 membered heterocycloalkyl moiety substituted with 1-2 G groups;
R6 is hydrogen, C1-6alkyl, cyano-C1-6alkylene optionally substituted with 1-2 G groups, or C3-6cycloalkyl optionally substituted with 1-2 G2 groups;
R7 is hydrogen or C1-6alkyl;
or R6 and R7, together with the N atom to which they are attached, join to form a heterocycloalkyl moiety substituted with 1-2 G groups;
R8 is C1-3alkyl, hydroxy-C1-6alkyl, halo-C1-6alkyl, cyano-C1-6alkylene, —[C(R9)2]1-2—C3-6cycloalkyl, —[C(R9)2]1-2-heterocycloalkyl, —[C(R9)2]1-2-heteroaryl, —[C(R9)2]1-2—SO2—C1-3alkyl, —[C(R9)2]1-2—C(O)—C1-3alkyl, —[C(R9)2]1-2—C(O)—N(C1-3alkyl)2, —[C(R9)2]1-2—C(O)—NH2, —[C(R9)2]1-2—C(O)—C3-6cycloalkyl, or —[C(R9)2]1-2—C(O)-heterocycloalkyl, or —CH2—C(O)-pyridyl;
each R9 is independently selected from hydrogen, C1-6alkyl, C3-6cycloalkyl, halo, and halo-C1-6alkyl;
each R10 is C1-3alkyl or two R10, together with the C atom to which they are attached, join to form a C3-6 cycloalkyl;
each G is independently hydroxyl, C1-6alkyl, C3-6 cycloalkyl, or heterocycloalkyl;
each G2 is independently C1-6alkyl, halogen, or cyano;
m is 0, 1, or 2; and
n is 0 or 2;
provided that the compound is not
N-(2-cyano-2-methyl-propyl)-6-[2-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(2-cyano-2-methyl-propyl)-6-[2-[1-(difluoromethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-[1-(difluoromethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-(2-isopropyl-4-methyl-thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
6-[2-[1-(2-cyanoethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(1-cyano-1-methyl-ethyl)pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-[1-(2-morpholinoethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-(1-isopropyl-3-methyl-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
6-[3-chloro-2-[1-(difluoromethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(1-cyano-1-methyl-ethyl)pyridine-2-carboxamide,
6-[3-chloro-2-(1-isopropyl-3-methyl-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(1-cyano-1-methyl-ethyl)pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(2-cyanopropan-2-yl)-6-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)picolinamide,
N-(2-cyanopropan-2-yl)-6-(2-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)picolinamide,
N-(2-cyanopropan-2-yl)-6-(2-(1-(oxetan-3-ylmethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)picolinamide, and
N-(2-cyanopropan-2-yl)-6-(2-(1-((methylsulfonyl)methyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)picolinamide.

US Pat. No. 10,428,062

GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF ?7-NICOTINIC ACETYLCHOLINE RECEPTORS

Axovant Sciences GmbH, B...

1. A compound represented by Formula (Ia) or Formula (Ib):wherein:R1 and R2 independently represent an unbranched C1-C4-alkyl radical or a branched C3-C4-alkyl radical; or the C(R1)(R2) moiety forms a (3-4 membered)-carbocycle, wherein R1 and R2 taken together represent a C2-C3-alkyl di-radical; wherein the unbranched C1-C4-alkyl radical, the branched C3-C4-alkyl radical, and the C2-C3-alkyl di-radical may be independently substituted with up to 4 radical substituents selected from the group consisting of: -D, —F, —Cl, —CN, —CH3, —CH2CH3, ?O, and —OR3;
R3 independently represents —H; an unbranched C1-C4-alkyl radical; a branched C3-C4-alkyl radical; or a C3-C4-cycloalkyl radical; wherein the unbranched C1-C4-alkyl radical, the branched C3-C4-alkyl radical, and the C3-C4-cycloalkyl radical may be independently substituted with up to 4 radical substituents selected from the group consisting of: -D, —F, —Cl, —CN, ?O, —OH, —OC1-C4-alkyl, and —OCF3,
R4 and R5 independently represent —H, -D, or halogen radical;
R6 independently represents —F, —Cl, —Br, —CN, —CH3, —CH2CH3, cyclopropyl radical, —CHF2, —CH2F, —CF3, —CH2CF3, —OCH3, —OCH2CH3, —OCH(CH3)2, —O-cyclopropyl, or —OCF3; and
R7 independently represents —H, -D, —F, —Cl, —CN, —CH3, —CH(CH3)2, cyclopropyl radical, cyclobutyl radical, —CH2F, —CHF2, —CF3, —CH2CF3, —OCH3, —OH3, —OCH2CH3, —OCH(CH3)2, —O-cyclopropyl, —OCF3, or —OCH2CF3;or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,428,058

PRODRUGS OF NH-ACIDIC COMPOUNDS

ALKERMES PHARMA IRELAND L...

1. A compound of Formula XIH:
or a pharmaceutically acceptable salt thereof;wherein:X is —O—;
each G3 and G4 is independently selected from the group consisting of —N— and —C(R10)—[C(R10)(R11)]a—, wherein a is 0;
A is selected from the group consisting of absent, alkyl, alkenyl, alkynyl, —S—, —O—, —S(O)—, —S(O)2—, —S[C(R30)(R31)]u—, —S(O)[C(R30)(R31)]u—, —S(O)2[C(R30)(R31)]u—, —O[C(R30)(R31)]u—, —N(R30)—, —N(R30)[C(R31)(R32)]u—, —[C(R30)(R31)]u, —C(O)[C(R30)(R31)]u—;
B is absent, or a linker, wherein the linker is selected from the group consisting of a bond, a straight chain C1-C10 alkyl, C1-C10 alkenyl, C1-C10 alkynyl, C1-C10 alkoxy, alkoxyC1-C10alkoxy, C1-C10 alkylamino, alkoxyC1-C10alkylamino, C1-C10 alkylcarbonylamino, C1-C10 alkylaminocarbonyl, aryloxyC1-C10alkoxy, aryloxyC1-C10alkylamino, aryloxvC1-C10alkylamino carbonyl, C1-C10-alkylaminoalkylaminocarbonyl, C1-C10 alkyl(N-alkyl)aminoalkyl-aminocarbonyl, alkylaminoalkylamino, alkylcarbonylaminoalkylamino, alkyl(N-alkyl)aminoalkylamino, (N-alkyl)alkylcarbonylaminoalkylamino, alkylaminoalkyl, alkylaminoalkylaminoalkyl, alkylpiperazinoalkyl, piperazinoalkyl, alkylpiperazino, alkenylaryloxyC1-C10alkoxy, alkenylarylaminoC1-C10alkoxy, alkenylaryllalkylaminoC1-C10alkoxy, alkenylaryloxyC1-C10alkylamino, alkenylaryloxyC1-C10alkylaminocarbonyl, piperazinoalkylaryl, heteroarylC1-C10alkyl, heteroarylC2-C10alkenyl, heteroarylC2-C10alkynyl, heteroarylC1-C10alkylamino, heteroarylC1-C10alkoxy, heteroaryloxyC1-C10alkyl, heteroaryloxyC2-C10alkenyl, heteroaryloxyC2-C10alkynyl, heteroaryloxyC1-C10alkylamino or heteroaryloxyC1-C10alkoxy;
D is selected from the group consisting of absent, —O—, —NR33, —C(R34)(R35)—, —S—, —S(O)—, —S(O)2—, —C(O)—;
R1 is selected from the group consisting of —C(RA)(RB)—OC(O)OR20, —C(RA)(RB)—OC(O)R20, and —C(RA)(RB)—OC(O)NR20R21;
each R2, R30, R31, R32 R33, R34, and R35 is independently selected from the group consisting of absent, hydrogen, halogen, —OR10, —SR10, —NR10R11—, —C(O)R10, aliphatic, aryl, or heterocyclyl;
each RA and RB is independently selected from the group consisting of hydrogen, halogen, aliphatic, and aryl;
each R10 and R11 is independently hydrogen, halogen, aliphatic, or aryl; alternatively two R10 and R11 together with the atoms to which they are attached and any intervening atoms may form an additional 3, 4, 5, 6 or 7 membered ring;
each R20 and R21 is independently selected from hydrogen, aliphatic, or aryl;
R5 is selected from absent, hydrogen, halogen, —OR10, —SR10, —NR10R11—, —C(O)R10, aliphatic, and heterocyclyl;
or is selected from:

R100 and R101 each represent 1 to 4 substituents independently selected from hydrogen, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C8 alkoxy, C1-C8 alkylamino and aryl;
R103 is selected from hydrogen, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C8 alkoxy, C1-C8 alkylamino and aryl;
p is 0, 1, 2, or 3; and
u is independently 1, 2, 3, 4, 5, 6 or 7.

US Pat. No. 10,428,057

BICYCLO[1.1.1]PENTANE INHIBITORS OF DUAL LEUCINE ZIPPER (DLK) KINASE FOR THE TREATMENT OF DISEASE

Board of Regents, The Uni...

1. A method of treating a disease selected from the group consisting ofchemotherapy-induced cognitive deficits (CICD),
chemotherapy-induced cognitive impairment (CICI),
chemotherapy-induced peripheral neuropathy (CIPN),
diabetic neuropathy,
Alzheimer's disease,
amyotrophic lateral sclerosis,
frontotemporal dementia,
Huntington's disease,
Kennedy's disease,
Lewy body disease,
Parkinson's disease,
progressive supranuclear palsy,
spinocerebellar ataxia,
traumatic brain injury (TBI), and
traumatic injury to the central nervous system or peripheral nervous system neurons,
the method comprising administering to a patient in need thereof a therapeutically effective amount of a compound of Formula I:

or a pharmaceutically acceptable salt thereof,
wherein:
X1 is selected from C or N;
X2 is selected from C or N;
exactly one of X1 and X2 is N;
X3 is N;
X4 and X5 are C;
X1, X2, X3, X4, and X5 form a five membered heteroaryl;
R1 is selected from alkyl, cycloalkyl, or heterocycloalkyl, any of which is optionally substituted with one to three R5 groups;
R2 is H or is selected from alkyl, amino, aryl, cycloalkyl, haloalkyl, heteroalkyl, heteroaryl, heterocycloalkyl, or sulfonylalkyl, any of which is optionally substituted with one to three R6 groups;
R3 is selected from H, alkyl, (alkoxy)alkyl, (arylalkoxy)alkyl, (heteroarylalkoxy)alkyl, cyano, cycloalkyl, halo, haloalkoxy, or haloalkyl;
R4 is (NR4a)2, wherein each R4a is independently selected from hydrogen, C1-4alkyl, or C1-4haloalkyl;
or R3 and R4 together with the atoms to which they are attached form a 5- or 6-membered heteroaryl or heteroalkyl ring, optionally substituted with one to three R7 groups;
each R5 and R6 is independently selected from C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy, C1-4-alkylthio, C1-4haloalkylthio, aryl, heteroaryl, C3-7cycloalkyl, C3-7heterocycloalkyl, (aryl)C1-4alkyl, (heteroaryl)C1-4alkyl, (C3-7cycloalkyl)C1-4alkyl, (C3-7heterocycloalkyl)C1-4alkyl, (ethenyl)C1-4alkyl, (ethynyl)C1-4alkyl, (aryl)C1-4alkoxy, (heteroaryl)C1-4alkoxy, (C3-7cycloalkyl)C1-4alkoxy, (C3-7heterocycloalkyl)C1-4alkoxy, (aryl)C1-4alkylthio, (heteroaryl)C1-4alkylthio, (C3-7cycloalkyl)C1-4alkylthio, (C3-7heterocycloalkyl)C1-4alkylthio, amino, halo, hydroxy, cyano, or oxo; and
each R7 is independently selected from C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy, aryl, heteroaryl, C3-7cycloalkyl, C3-7heterocycloalkyl, (aryl)C1-4alkyl, (heteroaryl)C1-4alkyl, (C3-7cycloalkyl)C1-4alkyl, (C3-7heterocycloalkyl)C1-4alkyl, halo, hydroxy, cyano, or oxo.

US Pat. No. 10,428,050

SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS

PTC THERAPEUTICS, INC., ...

1. A compound of Formula (I):
or a form thereof, wherein
R1 is bicyclic heteroaryl or bicyclic heterocyclyl substituted on a carbon atom ring member with one, two, three or four R5 substituents, or on a nitrogen atom ring member with an oxygen atom substituent to form an N-oxide;
X is N or N substituted with an oxygen atom substituent to form an N-oxide;
R2 is amino;
R3 is hydrogen, cyano, halo, C1-8alkyl, amino, C1-8alkyl-amino or (C1-8alkyl)2-amino;
R4 is phenyl, optionally substituted with one, two, three or four R6 substituents;
R5 is independently selected from the group consisting of cyano, halo, hydroxyl, nitro, oxo, C1-8alkyl, cyano-C1-8alkyl, halo-C1-8alkyl, hydroxyl-C1-8alkyl, C1-8alkoxy, C1-8alkoxy-C1-8alkyl, halo-C1-8alkoxy, C2-8alkenyl, C1-8alkoxy-C2-8alkenyl, C2-8alkynyl, C1-8alkoxy-C2-8alkynyl, carboxyl, amino, C1-8alkyl-amino, (C1-8alkyl)2-amino, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl, (C1-8alkyl)2-amino-C1-8alkyl, hydroxyl-C1-8alkyl-amino, hydroxyl-C1-8alkyl-amino-C1-8alkyl, hydroxyl-C1-8alkyl-amino-C1-8alkyl-amino, C1-8alkyl-thio, C1-8alkyl-carbonyl, C1-8alkyl-carbonyl-amino, C1-8alkyl-carbonyl-oxy, C1-8alkyl-carbonyl-oxy-C1-8alkyl, C1-8alkoxy-carbonyl, C1-8alkoxy-carbonyl-C1-8alkyl, C1-8alkoxy-carbonyl-amino, C1-8alkyl-sulfonyl, C3-14cycloalkyl, aryl, aryl-C1-8alkyl, aryl-amino, aryl-C1-8alkyl-amino, heteroaryl, heteroaryl-C1-8alkyl and heterocyclyl, wherein C3-14cycloalkyl, aryl, heteroaryl or heterocyclyl and the aryl and heteroaryl portions of aryl-C1-8alkyl, aryl-amino, aryl-C1-8alky-amino and heteroaryl-C1-8alkyl are each optionally substituted with one, two, three or four halo, C1-8alkyl, halo-C1-8alkyl, hydroxyl-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, hydroxyl-C1-8alkoxy or carboxyl substituents;
R6 is independently selected from the group consisting of cyano, halo, nitro, C1-8alkyl, halo-C1-8alkyl, hydroxyl-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, C2-8alkenyl, C1-8alkoxy-C2-8alkenyl, C2-8alkynyl, C1-8alkoxy-C2-8alkynyl, carboxyl, formyl, formyl-oxy, C1-8alkyl-carbonyl, halo-C1-8alkyl-carbonyl, C1-8alkyl-thio, halo-C1-8alkyl-thio, amino, C1-8alkyl-amino, (C1-8alkyl)2-amino, C1-8alkyl-carbonyl, C1-8alkyl-carbonyl-oxy, C1-8alkyl-carbonyl-oxy-C1-8alkyl, C1-8alkoxy-carbonyl, halo-C1-8alkoxy-carbonyl, C1-8alkoxy-carbonyl-C1-8alkyl, C1-8alkoxy-carbonyl-amino, C1-8alkoxy-carbonyl-amino-C1-8alkyl, amino-carbonyl, C1-8alkyl-amino-carbonyl, (C1-8alkyl)2-amino-carbonyl, C1-8alkyl-carbonyl-amino, C1-8alkyl-carbonyl-amino-C1-8alkyl, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl, (C1-8alkyl)2-amino-C1-8alkyl, amino-C1-8alkyl-amino, C1-8alkyl-amino-C1-8alkyl-amino, (C1-8alkyl)2-amino-C1-8alkyl-amino, hydroxyl-C1-8alkyl-amino, hydroxyl-C1-8alkyl-amino-C1-8alkyl, hydroxyl-C1-8alkyl-amino-C1-8alkyl-amino, imino-C1-8alkyl, hydroxyl-imino-C1-8alkyl, C1-8alkoxy-imino-C1-8alkyl, C1-8alkyl-sulfonyl, halo-C1-8alkyl-sulfonyl, amino-sulfonyl, C1-8alkyl-amino-sulfonyl, (C1-8alkyl)2-amino-sulfonyl, B(OR8)2, C3-14cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein C3-14cycloalkyl, heterocyclyl, aryl, and heteroaryl are each optionally substituted with one, two, three or four halo or C1-8alkyl substituents;
R8 is independently hydrogen or C1-8alkyl;
wherein the form of the compound is selected from the group consisting of a free acid, free base, salt, ester, hydrate, solvate, chelate, clathrate, isotopologue, stereoisomer, racemate, enantiomer, diastereomer and tautomer thereof.

US Pat. No. 10,428,046

N-SUBSTITUTED SULFONAMIDE COMPOUND AND METHOD FOR PRODUCING SAME

UBE INDUSTRIES, LTD., Ub...

15. A compound of the general formula (9):
wherein R5 is an alkyl group, and X2 is a halogen atom or a hydroxyl group.

US Pat. No. 10,428,045

BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF

Silverback Therapeutics, ...

1. A conjugate represented by the formula:wherein Antibody is an antibody construct, L3 is a linker moiety, and D is a compound represented by the structure of Formula (IIB):or a pharmaceutically acceptable salt thereof, wherein:L10 is selected from —C(O)—, and —C(O)N(R10)—*, wherein * represents where L10 is bound to R5—;
L2 is selected from —C(O)— and —C(O)N(R10)—;
R1 and R2 are independently selected from hydrogen; and C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ?O, ?S, ?N(R10), and —CN;
R4 is selected from:
OR10, —N(R10)2, —C(O)N(R10)2, —C(O)R10, —C(O)OR10, —S(O)R10, and —S(O)2R10; and
C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ?O, ?S, ?N(R10), —CN, C3-12 carbocycle, and 3- to 12-membered heterocycle; and
C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ?O, ?S, ?N(R10), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
R5 is selected from unsaturated C4-8 carbocycle; bicyclic carbocycle; and fused 5-5, fused 5-6, and fused 6-6 bicyclic heterocycle, wherein R5 is optionally substituted and wherein substituents are independently selected at each occurrence from:
halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ?O, ?S, ?N(R10), and —CN; and
C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ?O, ?S, ?N(R10), —CN, C3-12 carbocycle, and 3- to 12-membered heterocycle; and
C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ?O, ?S, ?N(R10), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
R10 is independently selected at each occurrence from:
hydrogen, —NH2, and—C(O)OCH2C6H5; and
C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, ?O, ?S, —C(O)OCH2C6H5, —NHC(O)OCH2C6H5, C1-10 alkyl, —C1-10 haloalkyl, —O—C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle;
R20, R21, R22, and R23 are independently selected from hydrogen, halogen, —OR10, —SR10, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ?O, ?S, ?N(R10), —CN, C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl; and
R24 and R25 are independently selected from hydrogen, halogen, —OR10, —SR10, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ?O, ?S, ?N(R10), —CN, C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl; or R24 and R25 taken together form an optionally substituted saturated C3-7 carbocycle.

US Pat. No. 10,428,036

PROCESS FOR THE EPOXIDATION OF PROPENE

Evonik Degussa GmbH, Ess...

1. A process for the epoxidation of propene, comprising the steps:a) continuously reacting propene with hydrogen peroxide in the presence of an epoxidation catalyst, using propene in molar excess to hydrogen peroxide, to provide a reaction mixture comprising propene oxide, non-reacted propene and propane;
b) separating propene oxide and a recovered propene stream with a total content of propene and propane of more than 90% by weight from the reaction mixture obtained in step a);
c) feeding all or a part of said recovered propene stream to a C3 splitter column for separating propene and propane and withdrawing an overhead product stream depleted in propane with regard to said recovered propene stream and a bottoms product stream enriched in propane with regard to said recovered propene stream from said column; and
d) passing the overhead product stream obtained in step c) to step a);
wherein a propene starting material containing propane with a mass ratio of propane to the combined amount of propene and propane of from 0.002 to 0.10 is fed to said process for the epoxidation of propene, the reaction mixture provided in step a) comprises propane with a mass ratio of propane to the combined amount of propene and propane of from 0.05 to 0.20 and the overhead product stream withdrawn from the C3 splitter column comprises propane with a mass ratio of propane to the combined amount of propene and propane of at least 0.04.

US Pat. No. 10,428,030

HETEROCYCLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS

Trillium Therapeutics, M...

1. A compound of Formula (I), or a pharmaceutically acceptable salt, solvate, tautomer or optical isomer, or combination thereof:
wherein:
R1 is alkylene-phenyl substituted in the para position with R5;
R2 and R3 are each independently selected from the group consisting of hydrogen and fluorine;
R4 is hydrogen;
X is O;
Q is selected from CH2, O, and NR7;
R5 is fluoroalkoxy; and
R7 is selected from the group consisting of H, C1-C4 alkyl, and C1-C4haloalkyl.

US Pat. No. 10,428,029

ISOXAZOLE CARBOXAMIDE COMPOUNDS

EPIZYME, INC., Cambridge...

1. A compound having Formula I:
or a pharmaceutically acceptable salt or hydrate thereof,
wherein:
R1 is selected from the group consisting of C1-6 alkyl, C1-4 alkenyl, C1-4 haloalkyl, C3-6 cycloalkyl, and hydroxyalkyl;
R2 is selected from the group consisting of hydrogen, halo, and carboxamido;
A is optionally substituted 4- to 14-membered heterocyclenyl;
with the provisos:
a) when R1 is ethyl, n-propyl, isopropyl, isobutyl, or cyclopropyl; and R2 is hydrogen, then A is not optionally substituted, optionally bridged piperidinenyl; and
b) when R1 is C1-6 alkyl or C3-6 cycloalkyl; and R2 is hydrogen, then A is not optionally substituted pyrrolidinenyl;
X is selected from the group consisting of —S(?O)2—, —S(?O)2N(R7)—, —N(R7)S(?O)2—, —S(?O)2C(R8)(H)—, —C(?O)—, —C(?O)N(R7)—, —N(R7)C(?O)—, —C(?O)O—, —OC(?O)—, —C(?O)C(R8)(H)N(R7)—, —N(R7)C(?O)C(R8)(H)—, —C(R8)(H)C(?O)N(R7)—, —C(R8)(H)N(R7)C(?O)—, and —C(?O)C(R8)(H)—; or X is absent;
Z is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, fluoroalkyl, hydroxyalkyl, amino, alkylamino, dialkylamino, heterocycloamino, (amino)alkyl, (alkylamino)alkyl, (dialkylamino)alkyl, (cycloalkylamino)alkyl, (heterocyclo)alkyl, (cycloalkyl)alkyl, (amino)(hydroxy)alkyl, (amino)(aryl)alkyl, (amino)(heteroaryl)alkyl (hydroxy)(aryl)alkyl, (aralkylamino)alkyl, (hydroxyalkylamino)alkyl, alkoxyalkyl, optionally substituted C6-14 aryl, optionally substituted 4- to 14-membered heterocyclo, optionally substituted 5- to 14-membered heteroaryl optionally substituted C3-12 cycloalkyl, aralkyl, and (heteroaryl)alkyl;
wherein —X—Z is attached to any available carbon or nitrogen atom of A;
R7 is selected from the group consisting of hydrogen and C1-4 alkyl; and
R8 is selected from the group consisting of hydrogen, C1-4 alkyl, hydroxy, amino, alkylamino, dialkylamino, cycloalkylamino, (amino)alkyl, (alkylamino)alkyl, (dialkylamino)alkyl, and hydroxyalkyl.

US Pat. No. 10,428,028

HDAC INHIBITORS

BIOMARIN PHARMACEUTICAL I...

1. A method of treating a disease or disorder wherein the disease or disorder is a neurological disorder selected from myotonic dystrophy, spinal muscular atrophy, fragile X syndrome, Huntington's disease, spinocerebellar ataxia, Kennedy's disease, amyotrophic lateral sclerosis, Niemann Pick, Pitt Hopkins, spinal and bulbar muscular atrophy, and Alzheimer's disease; an inflammatory disease; a memory impairment condition; or a drug addiction in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound having a structure of formula (I), or a pharmaceutically acceptable salt thereof:
wherein:
R1—X is attached to only one of the ring nitrogen atoms;
X is:
(i) —Y—[C(Ra)2]a-A-[C(Rb)2]b—B—;
(ii) direct bond; or
(iii) C?O, C(Rj)2—C(?O), C(?O)—C(Rj)2, SO2—NRk, NRk—SO2, C(?O)NRk or NRk—C(?O);wherein:Y is bond, CRc?CRd, O, NRe, or S(O)m;
each of A and B is, independently, a bond, O, NRe, or S(O)m;
a is 1, 2, or 3;
b is 0, 1, 2, or 3;
m is 0, 1, or 2;
each occurrence of Ra and Rb is independently selected from H, F, OH, C1-C6 alkyl, C3-C6 cycloalkyl, NH2, OCO—(C1-C6 alkyl), OCO—(C3-C6 cycloalkyl), C1-C6 alkoxy, C1-C6 fluoroalkoxy, and cyano; or
one or more of the following can apply with respect to Ra and Rb:
any two Ra, together with the carbons to which each is attached, together form C3-C6 cycloalkyl or heterocyclyl including 3-6 ring atoms, in which one of the heterocyclyl ring atoms is selected from O, S(O)m and NRg; or
one Re and one Rb, together with the carbons to which each is attached, form C3-C6 cycloalkyl or heterocyclyl including 3-6 ring atoms, in which one of the heterocyclyl ring atoms is selected from O; S(O)m and NRg; or
any two Rb, together with the carbons to which each is attached, form C3-C6 cycloalkyl or heterocyclyl including 3-6 ring atoms, in which one of the ring atoms is selected from O; S(O)m and NRg;
each of Rc and Rd is independently selected from H, F, OH, C1-C6 alkyl, C3-C5 cycloalkyl, NH2, OCO—(C1-C6 alkyl), OCO—(C3-C5 cycloalkyl), C1-C6 alkoxy, C1-C6 fluoroalkoxy, and cyano;
or Rc and Rd, together with the carbons to which each is attached form a C5-C7 cycloalkyl or heterocyclyl including 3-6 ring atoms, in which from 1-2 of the heterocyclyl ring atoms are independently selected from O, S(O)m and NRg?;
each occurrence of Re, Rf, Rg and Rg? is independently selected from H, C1-C6 alkyl, —C(?O)H, —C(?O)Rh, C(?O)O(C1-C6 alkyl), C(?O)N(Rj)2, and SO2—Rh; wherein Rh is selected from C1-C6 alkyl, CH2-(heteroaryl including 5-10 ring atoms), CH2—(C6-C10 aryl), and C6-C10 aryl; and each occurrence of Ri is independently selected from H, C1-C6 alkyl, CH2-(heteroaryl including 5-10 ring atoms), CH2—(C6-C10 aryl), and C6-C10 aryl;
each occurrence of Rj is independently selected from H, F, OH, C1-C6 alkyl, C3-C6 cycloalkyl, NH2, OCO—(C1-C6 alkyl), OCO—(C3-C6 cycloalkyl), C1-C6 alkoxy, C1-C6 fluoroalkoxy, and cyano;
or Rj—C—Rj together form C3-C6 cycloalkyl or heterocyclyl including 3-6 ring atoms, in which one of the heterocyclyl ring atoms is selected from O; S(O)m and NRj?;
each occurrence of Rj? and Rk is independently selected from H, C1-C6 alkyl, —C(?O)H, —C(?O)Rm, C(?O)O(C1-C6 alkyl), C(?O)N(Rn)2, and SO2—Rm, wherein Rm is selected from C1-C6 alkyl, CH2-(heteroaryl including 5-10 ring atoms), CH2—(C6-C10aryl), and C6-C10aryl; and each occurrence of Rn is independently selected from H, C1-C6 alkyl, CH2-(heteroaryl including 5-10 ring atoms), CH2—(C6-C10 aryl), and C6-C10 aryl, and wherein the aryl and heteroaryl portion in Rm and Rn can be optionally substituted with 1-3 independently selected substituents F, C1-C6 alkyl, fluoro C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 fluoroalkoxy, or cyano;further wherein:(a) when each of A and B is a bond, and b is 0, then X has the following formula: —Y—[C(Ra)2]a—;
(b) when b is 0 or 1, then A and B cannot both be heteroatoms; and
(c) when A or B serves as the point of connection of X to the nitrogen ring atoms, then A or B cannot be a heteroatom;
R1 is:
(i) monocyclic or bicyclic heteroaryl including from 5-10 ring atoms, which is optionally substituted with from 1-3 Ro; wherein from 1-4 of the ring atoms are a heteroatom independently selected from O, N, N—H, N—Ro, and S;
(ii) C6-C10 aryl, which is optionally substituted with from 1-3 Ro;
(iii) C3-C10 cycloalkyl or C3-C10 cycloalkenyl, each of which is optionally substituted with from 1-6 Ro; or
(iv) hydrogen;
R4 is H or Ro and each occurrence of Ro is independently selected from the group consisting of halogen; C1-C6 alkyl; fluoro(C1-C6)alkyl; hydroxyl; hydroxy(C1-C4)alkyl; C1-C6 alkoxy; fluoro(C1-C6)alkoxy; (C1-C6 alkyl)C(O)—; (C1-C6 alkyl)NH—; (C1-C6 alkyl)2N—; —N*(Ro?)2, wherein Ro?—N*—Ro? together form a saturated ring having 5 or 6 ring atoms, in which 1 or 2 ring atoms are optionally a heteroatom independently selected from NH, N(C1-C6alkyl), O, or S; formyl; formyl(C1-C4) alkyl; cyano; cyano(C1-C4) alkyl; benzyl; benzyloxy; (heterocyclyl)-(C0-C6) alkyl, wherein the heterocyclyl portion includes 5 or 6 ring atoms, in which 1 or 2 of the ring atoms are a heteroatom independently selected from NH, N(alkyl), O, or S; phenyl; heteroaryl including from 5-6 ring atoms, wherein from 1-4 of the ring atoms are a heteroatom independently selected from O, N, N—H, N—Ro?, and S, each of which is optionally substituted with from 1-3 Ro?; SO2—(C1-C6)alkyl; SO—(C1-C6)alkyl; and nitro;
each occurrence of Ro? is independently selected from the group consisting of halogen; C1-C6 alkyl; fluoro(C1-C6)alkyl; hydroxyl; hydroxy(C1-C4)alkyl; C1-C6 alkoxy; fluoro(C1-C6)alkoxy; (C1-C6 alkyl)C(O)—; (C1-C6 alkyl)NH—; (C1-C6 alkyl)2N—; formyl; formyl(C1-C4) alkyl; cyano; cyano(C1-C4) alkyl; benzyl; benzyloxy; (heterocyclyl)-(C0-C6) alkyl, wherein the heterocyclyl portion includes 5 or 6 ring atoms, in which 1 or 2 of the ring atoms are a heteroatom independently selected from NH, N(C1-C6alkyl), 0, or S; phenyl; heteroaryl including from 5-6 ring atoms, wherein from 1-4 of the ring atoms are a heteroatom independently selected from O, N, N—H, N—(C1-C6 alkyl), and S; SO2—(C1-C6)alkyl; SO—(C1-C6)alkyl; and nitro;
R5 is selected from the group consisting of: hydrogen, halogen; C1-C6 alkyl;
fluoro(C1-C6)alkyl; hydroxyl; hydroxy(C1-C4)alkyl; (C1-C6 alkyl)C(O)—; formyl; formyl(C1-C4) alkyl; cyano; cyano(C1-C4) alkyl; benzyl; (heterocyclyl)-(C0-C6)alkyl, wherein the heterocyclyl portion includes 5 or 6 ring atoms, in which 1 or 2 of the ring atoms are a heteroatom independently selected from NH, N(C1-C6alkyl), O, or S; phenyl; heteroaryl including from 5-6 ring atoms, wherein from 1-4 of the ring atoms are a heteroatom independently selected from O, N, N—H, and S; SO2—(C1-C6)alkyl; SO—(C1-C6)alkyl; and nitro;
R2 is selected from H, F, Cl, CF3, CF2CF3, CH2CF3, OCF3, OCHF2, phenyl; or phenyl substituted with 1-3 Ro; and
R3 is H, F, or Cl.

US Pat. No. 10,428,027

SULFINYLPHENYL OR SULFONIMIDOYLPHENYL BENZAZEPINES

Hoffmann La-Roche Inc., ...

1. A compound of the formulawhereinX is C—R7 or N;
R1 is C3-7-alkyl or C3-7-cycloalkyl,
R2 is selected from the group consisting of C3-7-alkyl, hydroxy-C1-7-alkyl, C3-7-alkynyl, amino-C1-7-alkoxy-C1-7-alkoxy-C1-7-alkyl, halogen-C1-7-alkyl and C3-7-cycloalkyl-C1-7-alkyl;one of R3 and R4 isand the other one of R3 and R4 is selected from the group consisting of hydrogen, C1-7-alkyl and halogen;R5, R6 and R7 are independently from each other selected from hydrogen, C1-7-alkyl and halogen;
R8 is C1-7-alkyl;
R9 is absent or is ?N—R10, wherein R10 is selected from the group consisting of hydrogen, C1-7-alkyl, halogen-C1-7-alkyl, hydroxy-C1-7-alkyl and hydroxy-C1-7-alkoxy-C1-7-alkyl,or pharmaceutically acceptable salts thereof.

US Pat. No. 10,428,022

IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES

Emergent Virology LLC, G...

1. A compound of formula IA:
or a pharmaceutically acceptable salt thereof, wherein R is
a)
wherein optionally, at least one CX group inis replaced with N; orb)
wherein X6 is O or S; andwherein each of W1-W4 is independently H or a C1-C3 alkyl group;
R1 is a C1-C12 alkyl group; and
wherein each of X1-X5 is independently selected from the group consisting of H, N3, NO2, NH2,
and a group comprising a heteroatom containing ring,wherein each of R2 and R3 is independently selected from the group consisting of H, C1-C3 alkyl, and C1-C3 hydroxyalkyl; and R4 and R5 are each H, or R4 and R5 are together ?N—OH, provided that at least one of X1-X5 is
or the group comprising a heteroatom containing ring; orwherein each of X1-X5 is independently selected from the group consisting of H, N3, NO2, and NH2, and wherein two of X1-X5, which are adjacent, form a heteroatom containing ring.

US Pat. No. 10,428,018

ROR GAMMA (RORY) MODULATORS

LEAD PHARMA HOLDING B.V.,...

1. A compound according to Formula Ior a pharmaceutically acceptable salt thereof wherein:A1-A8 are CR1-CR8;
R1-R8 are independently H, halogen, amino, C(1-3)alkoxy, (di)C(1-3)alkylamino or C(1-6)alkyl;
R9 is C(1-6)alkyl;
R10 and R11 are independently H, F, methyl, ethyl, hydroxy or methoxy or R10 and R11 together is carbonyl, all alkyl groups, if present, optionally being substituted with one or more F;
R12 is H or C(1-6)alkyl;
R13 is C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(2-5)heterocycloalkyl, C(2-5)heterocycloalkylC(1-3)alkyl, C(6- 10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)hetero-aryl or C(1-9)heteroarylC(1-3)alkyl, all groups optionally substituted with one or more halogen, amino, hydroxy, cyano, C(1-3)alkoxy, C(1-3)alkoxycarbonyl, (di)C(1-3)alkylamino or C(1-3)alkyl;
R14 is H, C(1-6)alkyl, C(2-6)alkenyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(2-5)heterocycloalkyl, C(2-5)heterocycloalkylC(1-3)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl or C(1-9)heteroarylC(1-3)alkyl, all groups optionally substituted with one or more halogen, amino, hydroxy, cyano, C(1-3)alkoxy, C(1-3)alkoxycarbonyl, (di)C(1-3)alkylamino or C(1-3)alkyl;
or R13 and R14 are fused and form a ring having 5 to 7 atoms by joining R13 being C(1-6)alkyl or C(2-6)alkenyl with an independent substituent within the definition of R14, all groups optionally substituted with one or more halogen, amino, hydroxy, cyano, C(1-3)alkoxy, C(1-3)alkoxycarbonyl, (di)C(1-3)alkylamino or C(1-3)alkyl;
the term C(1-9)heteroaryl denotes an aromatic group having 1-9 carbon atoms and 1-4 heteroatoms, which is attached via a nitrogen atom or a carbon atom, and all carbon atoms of the aromatic group may optionally be substituted with one or more halogen or methyl;
the term C(2-5)heterocycloalkyl denotes a saturated cyclic hydrocarbon group having 2-5 carbon atoms and 1-3 heteroatoms, which is attached via a nitrogen atom or a carbon atom, and all carbon atoms of the saturated cyclic hydrocarbon group may optionally be substituted with one or more halogen or methyl; and
the term heteroatom denotes a nitrogen, sulfur or oxygen atom.

US Pat. No. 10,428,015

ACID-RESISTANT BASE AND/OR RADICAL GENERATOR, AND CURABLE RESIN COMPOSITION CONTAINING SAID BASE AND/OR RADICAL GENERATOR

FUJIFILM Wako Pure Chemic...

1. A compound represented by the general formula (A):
wherein four pieces of R1 each independently represent a hydrogen atom or a fluorine atom; four pieces of R2 each independently represent a fluorine atom or a trifluoromethyl group; R3, R6, R7 and R10 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms; R4 and R5 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, or R4 and R5 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; and R8 and R9 each independently represent a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, or an aryl group having 6 to 14 carbon atoms and optionally having a substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, a dialkylamino group having 2 to 12 carbon atoms, a halogen atom, and a nitro group, or R8 and R9 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; provided that two or three of the eight groups R3 to R10 are each a hydrogen atom, and, in a case where two of the eight groups are each a hydrogen atom, then three to six of the remaining groups are each an alkyl group having 1 to 12 carbon atoms, and, in a case where three of the eight groups are each a hydrogen atom, then four or five of the remaining groups are each an alkyl group having 1 to 12 carbon atoms.

US Pat. No. 10,428,013

AMIDE COMPOUND, PREPARATION METHOD AND USES THEREOF

Shanghai Institute of Pha...

1. A compound and pharmaceutically acceptable salts thereof, wherein the compound is selected from:

US Pat. No. 10,428,010

PROCESS TO CONVERT CYCLIC ALKYLENE UREAS INTO THEIR CORRESPONDING ALKYLENE AMINES

Nouryon Chemicals Interna...

1. Process to convert cyclic alkylene ureas into their corresponding alkylene amines wherein the process is performed by reaction with an amine compound, and wherein the amine compound is chosen from the group of primary amines, cyclic secondary amines or bicyclic tertiary amines;wherein the cyclic alkylene urea reacts to the corresponding alkylene amine in accordance with below reaction

wherein R1 and R2 each independently are chosen from the group of hydrogen, an alkylene amine group of the formula X—R3—(NH—R3—)p—, or an alkoxy group of formula X—R3—(O—R3—)n—, or a group combining such alkylene amine and alkoxy units p and n, wherein optionally one or more units ˜N—R3—N˜ may be present as either one of the rings

and wherein each R3 independently is alkylene or substituted alkylene, X may be hydroxyl, amine, a linear or branched C1-C20 hydroxyalkyl or a linear or branched C1-C20 aminoalkyl group, n and p independently are 0 or at least 1, wherein when n and/or p is at least 1 the linear or branched C1-C20 hydroxyalkyl or C1-C20 aminoalkyl croup optionally contains one or more piperazine or alkylene urea groups.

US Pat. No. 10,428,008

NITROALKENE NON STEROIDAL ANTI-INFLAMMATORY DRUGS (NA-NSAIDS) AND METHODS OF TREATING INFLAMMATION RELATED CONDITIONS

Institut Pasteur de Monte...

1. A compound of Formula I:
wherein R is hydrogen or a C1-11 alkyl, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,427,993

PROCESS FOR RECOVERING BENZENE AND FUEL GAS IN AN AROMATICS COMPLEX

UOP LLC, Des Plaines, IL...

1. A process for the recovery of a benzene rich liquid stream and a light ends vapor stream in a xylene isomerization process from a feedstock, the process comprising:passing a feedstock into a deheptanizer in which the feedstock is separated into a deheptanizer vapor phase and a deheptanizer liquid phase, the deheptanizer vapor phase containing hydrocarbons with seven carbon atoms or less, and the deheptanizer liquid phase containing hydrocarbons with eight carbon atoms or more;
passing the deheptanizer vapor phase from the deheptanizer to a first separation zone;
separating the deheptanizer vapor phase in the first separation zone into a first liquid phase and a first vapor phase;
passing the first liquid phase from the first separation zone to a toluene recovery zone;
passing the first vapor phase from the first separation zone to a compression zone in which the first vapor phase is compressed and partially condensed to provide a compressed and partially condensed vapor phase;
passing the compressed and partially condensed vapor phase from the compression zone to a second separation zone;
separating the compressed and partially condensed vapor phase into the benzene rich liquid stream and a second vapor phase in the second separation zone, the second vapor phase being a light ends vapor stream;
recovering the light ends vapor stream;
recovering the benzene rich liquid stream; and
sending the benzene rich liquid stream to extraction.

US Pat. No. 10,427,991

CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION AND METHOD FOR OLEFIN OLIGOMERIZATION USING THE SAME

LG CHEM, LTD., Seoul (KR...

1. A catalyst system for olefin oligomerization comprising:at least one ligand compound represented by the following Chemical Formulas:

a chromium source; and
a support wherein the ligand compound is supported on the support.

US Pat. No. 10,427,988

METHOD AND INSTALLATION FOR TREATING A WASTE MIXTURE, INCLUDING SEPARATION AND COMPOSTING OF SAID MIXTURE

20. A plant for treating mixture of wastes (2), the latter being with heterogeneous sizes, shapes and consistencies, a non-negligible portion of the mass of the mixture of wastes (2) being formed by biodegradable wastes, and a non-negligible portion of the mass of the mixture being formed by non-biodegradable recyclable wastes (26), the treatment plant being characterized in that it comprises:a sorting machine (1), allowing separating the mixture of wastes (2) into a first fraction of wastes (13) the size of which is smaller than about 180 mm via a first series of separation orifices (7, 8), said first series of separation orifices (7, 8) comprising primary orifices (7) and secondary orifices (8) the size of which is larger than the size of the primary orifices (7) so that the mixture of wastes (2) is first brought into contact with the secondary orifices and then with the primary orifices (7), and into a residual second fraction of wastes (14),
a composting plant allowing subjecting the first fraction of wastes (13) to a composting process so as to compost, at least partially, the contained biodegradable wastes, characterized in that the composting plant comprises:
at least one first composting bay (3C) allowing subjecting the first fraction of wastes (13) to a first composting cycle so as to compost, at least partially, the biodegradable wastes of said first fraction of wastes (13), and to obtain a mixture of pre-composted wastes (2),
at least one bay (2C) for drying the mixture of pre-composted wastes (2), allowing obtaining a mixture of dried wastes (2),
means for separating the mixture of dried wastes (2) at least into a portion of heavy wastes (25) and a portion of light wastes, the portion of heavy wastes (25) being substantially formed by wastes with a volumetric mass heavier than the wastes of the portion of light wastes,
at least one second composting bay (3C) allowing subjecting the portion of light wastes to a second composting cycle so as to compost, at least partially, the contained biodegradable wastes, and obtain a mixture of refined wastes (28).

US Pat. No. 10,427,985

ENGINEERED MICRO-VOIDS FOR TOUGHENING CERAMIC COMPOSITES

Lockheed Martin Corporati...

1. A ceramic composite material comprising:a ceramic compound;
a plurality of shaping particles dispersed in the ceramic compound; and
a plurality of a first type of void spaces dispersed in the ceramic compound;
wherein:
the plurality of shaping particles are contained within the plurality of the first type of void spaces;
the shaping particles comprise nanostructures have a length to diameter ratio of less than or equal to 10 to 1 and a length of less than or equal to 500 nanometers; and
each of the plurality of the first type of void spaces is a closed cell.

US Pat. No. 10,427,984

SYSTEMS AND METHODS FOR CERAMIC MATRIX COMPOSITES

United Technologies Corpo...

1. A ceramic matrix composite formed by a process comprising:inserting a fiber tow in a mold;
introducing an aqueous solution comprising water, carbon nanotubes, and a binder into the mold;
freezing the aqueous solution, wherein the freezing the aqueous solution separates fibers within the fiber tow;
freeze drying the aqueous solution, wherein the freeze drying removes the water from the mold;
heat treating the fiber tow in the presence of a boron-bearing precursor and nitrogen gas to produce boron nitride nanotubes; and
processing the mold via at least one of slurry casting, chemical vapor infiltration, polymer infiltration and pyrolysis, or melt infiltration.

US Pat. No. 10,427,982

METHOD OF CARBON COATING ON NANOPARTICLE AND CARBON COATED NANOPARTICLE PRODUCED BY THE SAME

KOREA INSTITUTE OF ENERGY...

1. A method including:supplying only nanoparticles and sources of any one or two or more combinations selected from a group which consists of a carbon source, a doping source, a carbon source capable of providing a doped element, and a waste plastic source into a high-temperature and high-pressure closed autoclave;
completely closing the high-temperature and high-pressure closed autoclave; and
forming a core-shell structure of the nanoparticle-a carbon shell or a core-shell structure of the nanoparticle-a carbon shell having the doped element by a single process under self-generated pressure and a first reaction temperature in the range of 500 to 850° C. by heating the autoclave,
wherein the method further comprises an additional functioning:
making the autoclave to a high-temperature and atmospheric state by removing gas from the autoclave in a state of high-temperature and high-pressure and thereafter, purging the autoclave by using an inert gas;
changing temperature up to a second reaction temperature for functioning and performing reaction while supplying a reaction gas; and
cooling the autoclave to room-temperature while purging the autoclave with an inert gas.

US Pat. No. 10,427,981

PIEZOELECTRIC MATERIAL, METHOD OF MANUFACTURING THE SAME, PIEZOELECTRIC ELEMENT, AND PIEZOELECTRIC ELEMENT APPLICATION DEVICE

Seiko Epson Corporation, ...

1. A piezoelectric material, containing:a first component which is a rhombohedral crystal in a single composition, in which a Curie temperature is Tc1, and which is composed of a lead-free-system composite oxide having a perovskite-type structure;
a second component which is a crystal other than the rhombohedral crystal in a single composition, in which a Curie temperature Tc2 is lower than Tc1, and which is composed of Li, K, Na, and Nb; and
a third component which is a crystal other than the rhombohedral crystal in a single composition similar to the second component, in which a Curie temperature Tc3 is equal to or higher than Tc1, and which is composed of K, Na, and Nb,
wherein when a molar ratio of the third component to the sum of the second component and the third component is set as ? and ?×Tc3+(1??)×Tc2 is set as Tc4, |Tc4?Tc1| is 50° C. or lower.

US Pat. No. 10,427,976

GLASS TUBE WITH INFRARED LIGHT REFLECTIVE COATING, METHOD FOR MANUFACTURING THE GLASS TUBE, HEAT RECEIVER TUBE WITH THE GLASS TUBE, PARABOLIC TROUGH COLLECTOR WITH THE HEAT RECEIVER TUBE AND USE OF THE PARABOLIC TROUGH COLLECTOR

SIEMENS CONCENTRATED SOLA...

1. A heat receiver tube for absorbing solar energy and for transferring absorbed solar energy to a heat transfer fluid located inside a core tube of the heat receiver tube, wherein:the heat transfer fluid is a thermo-oil;
the core tube comprises a core tube surface with a solar energy absorptive coating for absorbing solar absorption radiation of the sunlight;
the core tube is enveloped by an encapsulation with a glass tube with a glass tube wall, wherein a space between the core tube and the encapsulation is evacuated;
an inner surface of the glass tube wall comprises at least partially at least one infrared light reflective coating;
the infrared light reflective coating includes a transparent conducting coating comprising indium tin oxide, wherein the transparent conducting coating is configured to permit solar absorption radiation to impinge the core tube, and wherein the transparent conducting coating is configured to capture infrared radiation radiating from the core tube and direct the infrared radiation back to the core tube;
an intermediate layer of aluminum oxide arranged between the inner surface of the glass tube wall and the infrared light reflective coating;
an additional layer of aluminum oxide or silicon oxide covering the infrared light reflective coating, wherein the additional layer is between the infrared light reflective coating and the solar energy absorptive coating such that the additional layer is adjacent to the infrared light reflective coating and the space;
the core tube surface and the encapsulation are arranged in a distance between the core tube surface and the inner surface of the glass tube wall with the infrared reflective surface such, that the solar absorption radiation can penetrate the encapsulation with the infrared light reflective coating and can impinge the solar energy absorptive coating.

US Pat. No. 10,427,975

HIGH STRENGTH GLASS-CERAMICS HAVING PETALITE AND LITHIUM SILICATE STRUCTURES

Corning Incorporated, Co...

11. A glass-ceramic article comprising:Li2O;
SiO2;
Al2O3; and
a petalite crystalline phase,
wherein the article is transparent and has a transmittance of at least 85% for light in a wavelength range from 400 nm to 1,000 nm at a thickness of 1 mm, and
wherein the article has a fracture toughness of greater than 1.2 MPa·m1/2.

US Pat. No. 10,427,974

GLASS COMPOSITE FOR USE IN EXTREME ULTRA VIOLET LITHOGRAPHY

CORNING INCORPORATED, Co...

1. A glass composite for use in Extreme Ultra-Violet Lithography (EUVL), the glass composite comprising:a first silica-titania glass section; and
a second doped silica-titania glass section mechanically bonded to a surface of the first silica-titania glass section,
wherein the second doped silica-titania glass section has a thickness of greater than about 1.0 inch.

US Pat. No. 10,427,970

GLASS COATINGS AND METHODS TO DEPOSIT SAME

Owens-Brockway Glass Cont...

1. A method of producing a glass substrate, the method comprising:providing a silicate solution that includes a dissolved sodium silicate, the dissolved sodium silicate comprising a molar ratio of Na2O:SiO2;
adding a soluble calcium salt to the silicate solution to displace some of the sodium oxide in the dissolved sodium silicate with calcium oxide and to derive a wet precipitate that comprises a molar ratio of Na2O:CaO:SiO2;
removing solvent from the wet precipitate;
obtaining a dried glass precursor gel comprising a bulk amorphous oxide-based matrix having an inorganic network of primary constituent oxides, the primary constituent oxides comprising 60 mol % to 85 mol % silica (SiO2), 8 mol % to 18 mol % Na2O, and 5 mol % to 15 mol % CaO;
forming a powder or wire from the dried glass precursor gel;
melting the powder or wire with a gas stream to form molten droplets; and
depositing the molten droplets onto a mold to form the glass substrate.

US Pat. No. 10,427,969

METHOD OF MANUFACTURING OPTICAL FIBER

FUJIKURA LTD., Tokyo (JP...

1. A method of manufacturing an optical fiber comprising:melting and drawing an optical fiber preform to form a glass fiber in a drawer;
cooling the glass fiber while inserting the glass fiber into a tubular cooling device separated apart from the drawer with a gap therebetween and providing a temperature gradient to the glass fiber from an inlet end toward an outlet end thereof; and
lowering an inner wall temperature of the tubular cooling device below a temperature of the glass fiber and providing a pressure gradient in which a pressure increases in a direction from the inlet end toward the outlet end inside the tubular cooling device when cooling the glass fiber,
wherein an average pressure change dP/dL [Pa/m] in a moving direction of the glass fiber inside the tubular cooling device satisfies the following Formula (1) when a tube inner diameter of the tubular cooling device is defined as D [m] and a length of an internal space of the tubular cooling device in the moving direction of the glass fiber is defined as L [m]
0.001?(?D2/4)×dP/dL?0.03  (1).

US Pat. No. 10,427,968

METHOD FOR CUTTING GLASS

1. A method for cutting glass, comprising:providing a glass substrate, the glass substrate comprising at least one cutting surface, a plurality of micro-fractures being formed on the cutting surface;
coating a conductivity material on the cutting surface to form a conductivity material layer, the conductivity material layer having a capability for absorbing laser energy; and
irradiating the conductivity material layer by laser, causing the conductivity material layer to absorb the laser energy and transmit the laser energy to the glass substrate, thereby causing the laser energy to melt the glass substrate at the cutting surface to remove the plurality of micro-fractures.

US Pat. No. 10,427,967

PROCESS FOR THE MANUFACTURE OF A GLASS CONTAINER, GLASS CONTAINER AND RELATED USES

BORMIOLI LUIGI S.P.A., P...

1. A process for the manufacture of a glass container comprising the steps of:a) providing a first glass element;
b) providing a second element made of a material selected from: glass, ceramic, metal and metallic alloy; said first element and said second element, joined together, defining a containment cavity of said glass container;
c) depositing a sealing composition comprising at least one glass frit dispersed in at least one dispersing liquid on at least one surface of at least one of said first element and said second element, wherein said glass frit comprises, in percent by weight, based on the total weight of said glass frit:
(i) 20%-40% SiO2;
(ii) 30%-70% Bi2O3;
(iii) 1%-7% alkaline metal oxides;
(iv) 1%-25% of stabilizing oxides selected from the group consisting of transition metal oxides, Al2O3 and P2O5;
d) positioning said first element and said second element in contact with each other so that said sealing composition is arranged between said first element and said second element;
e) heating said sealing composition so as to melt said glass frit and form a sealing layer between said first element and said second element wherein said heating to melt said glass frit is carried out at a temperature in the range 500° C.-700° C.

US Pat. No. 10,427,964

ENHANCED PROCESS FOR SELECTIVE SALT RECOVERY FROM WASTEWATER, WASTE SALTS, AND BRINES

Veolia Water Technologies...

6. A method of treating a waste brine that includes an alkali metal, sulfate and chloride and producing sulfate and chloride salt crystals comprising:concentrating the waste brine;
directing the concentrated waste brine to a Mirabilite crystallizer and producing via cooling crystallization hydrated sulfate salt crystals and a chloride-rich brine stream;
separating the hydrated sulfate salt crystals from the chloride-rich brine stream;
melting the hydrated sulfate salt crystals to form an aqueous sulfate solution or a slurry;
directing the aqueous sulfate solution or slurry to a sulfate crystallizer and crystallizing anhydrous sulfate salts from the aqueous sulfate solution or slurry to form sulfate salt crystals comprising sulfate and at least one alkali metal;
removing sulfate and suspended solids from the chloride-rich brine stream produced by the Mirabilite crystallizer by directing the chloride-rich brine stream from the Mirabilite crystallizer through a nanofiltration device which produces a permeate stream and a reject stream containing the sulfate removed from the chloride-rich brine stream;
directing the permeate stream from the nanofiltration device to a chloride crystallizer and producing chloride salt crystals comprising chloride and at least one alkali metal;
recycling the reject stream produced by the nanofiltration device to the Mirabilite crystallizer and mixing the reject stream with the waste brine directed into the Mirabilite crystallizer.

US Pat. No. 10,427,961

TECHNOLOGIES FOR SANITIZING RESERVOIRS

SoClean, Inc., Peterboro...

1. A system for with a reservoir, comprising:a gas supply system comprising a pump and a gas generator, the gas supply system configured to supply a sanitizing gas;
a connector unit comprising an inlet passageway, the inlet passageway comprising a proximal end and a distal end;
a first supply line having a proximal and a distal end, wherein the proximal end of the first supply line is fluidly coupled to the gas supply system and the distal end of the first supply line is fluidly coupled to the proximal end of the inlet passageway;
a second supply line comprising a proximal end and a distal end, wherein the proximal end of the second supply line is coupled to the distal end of the inlet passageway; and
an exhaust system configured to remove the sanitizing gas, wherein the exhaust system comprises a filter that is integrated into the connector unit;
wherein the connector unit is configured to span a thickness of a portion of a reservoir when it is installed into said portion, such that the proximal end of the inlet passageway is external to the reservoir and the distal end of the inlet passageway is inside the reservoir.

US Pat. No. 10,427,960

METHOD FOR IMPROVING PERFORMANCE OF FLUID PROCESSING SYSTEM BASED ON CRYSTALLIZATION PROMOTING MEDIUM

1. A fluid processing apparatus, comprising:a fluid inlet tube, N column bed units in parallel connection, and a fluid outlet tube;
each column bed unit containing a crystallization promoting medium (CPM) as a fluid processing medium for processing the fluid flowing therein;
said N column bed units are all in fluid communication with the fluid inlet tube;
wherein N is an integer greater than 1, and except a first one of the column bed units, each column bed unit is provided with one check valve upstream thereof in an inflow direction, each check valve being designed to open and close under a specific fluid pressure;
wherein when a total number of the check valves is two or more, at least two check valves have different opening pressure thresholds and different closing pressure thresholds from each other;
wherein the CPM is a medium having nucleation sites of an atomic size on its surface which promote formation of crystals of a substance, when the substance dissolved in a fluid flows through the CPM, the substance is to form a crystal and grow at the nucleation sites, when the crystal grows to a certain size, the crystal is flushed off by the fluid to release reusable nucleation sites.

US Pat. No. 10,427,959

METHOD AND SYSTEM FOR THE AUTONOMOUS SELF-LIMITING GENERATION OF CHLORINE DIOXIDE

TRUOX, INC., McClellan, ...

1. A method for the autonomous generation of safe self-limiting concentrations of chlorine dioxide for the treatment of process water, the method comprising:in a system comprising:
a pressurized vessel containing a hydantoin based free halogen donor having a solubility between 0.075 to 0.30 wt % at 20° C., a source of water in fluid contact with the inlet to the pressurized vessel, a manifold in fluid contact with the outlet from the pressurized vessel, a manifold in fluid contact with the outlet from the pressurized vessel for introduction of at least a chlorite donor, a reaction chamber in fluid contact with the manifold and with the process water to be treated;
introducing said source water to dissolve hydantoin based free halogen donor until 50 to 100% of saturation is achieved to form an aqueous solution of free halogen, introducing chlorite donor to the manifold, producing chlorine dioxide in the reaction chamber, and said chlorine dioxide is introduced to the process water.

US Pat. No. 10,427,956

ULTRASOUND AND ACOUSTOPHORESIS FOR WATER PURIFICATION

FloDesign Sonics, Inc., ...

1. An apparatus comprising:a flow chamber for housing a mixture of a fluid and a particulate;
at least two ultrasonic transducers coupled to the flow chamber, each ultrasonic transducer including a piezoelectric material, wherein each ultrasonic transducer is configured to be excited to generate a multi-dimensional acoustic standing wave at a different ultrasonic frequency and wherein each ultrasonic frequency is generated for a specific range of particle sizes and each ultrasonic transducer is configured to generate a pressure field that is Bessel function; and
at least one reflector located on an opposite side of the flow chamber from the at least two ultrasonic transducers.

US Pat. No. 10,427,953

DITHIOCARBAMATE ALKALI METAL CROSS-LINKED RESIN FOR ADSORBING METAL IONS

King Fahd University of P...

1. An alkali metal cross-linked polymeric resin of formula (I)
n is a positive whole number in the range of 2 to 12;
X is a positive whole number in the range of 10 to 1,500; and
A1 forms a bond to A2.

US Pat. No. 10,427,950

RECOVERY OF MINING PROCESSING PRODUCT USING BORONIC ACID-CONTAINING POLYMERS

Ecolab USA Inc., St. Pau...

1. A method for solid-liquid separation in a mining process, the method comprising:combining a first composition with a fluid stream of a mining process, the first composition comprising an uncrosslinked polysaccharide, the fluid stream having a pH of 8 or more;
combining a second composition with the fluid stream, the second composition comprising a boronic acid-containing polymer; and
separating a solid from the fluid stream.

US Pat. No. 10,427,948

SYSTEMS AND METHODS FOR AMMONIA RECOVERY, ACID GAS SEPARATION, OR COMBINATION THEREOF

7. An integrated process for separating or recovering basic gases comprising:(1) a first cycle comprising:
absorbing ammonia from an ammonia containing gas stream into an ammonia-lean solution, forming an ammonia-rich solution;
enriching said ammonia rich solution with one or more acid gases;
precipitating one or more ammonia-acid gas salts wherein said precipitating occurs during enriching, after enriching, or a combination thereof; and
separating at least a portion of said precipitate from any remaining liquid; and
(2) a second cycle comprising:
(a) absorbing ammonia from an ammonia containing gas stream into an ammonia-lean, an ammonia-ultra-lean, or ammonia-free solution, to form an ammonia-rich solution;
(b) enriching said ammonia-rich solution with one or more acid gases to form an ammonia-rich, acid gas rich solution; and
(c) concentrating said ammonia-rich, acid gas rich solution using one or more membranes to form a retentate and a permeate wherein said permeate is suitable for use as at least a portion of the ammonia-ultra-lean or ammonia-free solution in step (a) of the second cycle.

US Pat. No. 10,427,947

METHODS FOR PRODUCING CRYSTALLINE MICROPOROUS SOLIDS WITH THE RTH TOPOLOGY AND COMPOSITIONS DERIVED FROM THE SAME

California Institute of T...

1. A process for preparing a crystalline microporous solid of RTH topology, the process comprising hydrothermally treating a composition comprising:(a) (i) at least one source of silicon oxide and
(ii) at least one source of aluminum oxide, boron oxide, gallium oxide, hafnium oxide, iron oxide, tin oxide, titanium oxide, indium oxide, vanadium oxide, zirconium oxide, or combination or mixture thereof
in the presence of an organic complex comprising
(b) an imidazolium cation comprising methyl and ethyl groups and having a C/N+ ratio in a range of from 6:1 to 10:1; and
(c) an associated hydroxide or fluoride anion;
under conditions effective to crystallize the crystalline microporous solid of RTH topology.

US Pat. No. 10,427,946

MECHANOCHEMICAL SYNTHESIS OF IRIDIUM DIBORIDE AND IRIDIUM MONOBORIDE

University of Central Flo...

1. A composition comprising iridium diboride and iridium monoboride.

US Pat. No. 10,427,944

COMPOSITION FOR FORMING A SILICA BASED LAYER, SILICA BASED LAYER, AND ELECTRONIC DEVICE

Samsung SDI Co., Ltd., Y...

1. A composition for forming a silica based layer, the composition comprising polysilazane having polydispersity ranging from about 7.0 to about 13.6 and a solvent, andhaving viscosity ranging from about 1.35 centipoise (cps) to about 1.60 cps when measured at a measurement temperature of 25° C.

US Pat. No. 10,427,943

LI-CONTAINING SILICON OXIDE POWDER AND PRODUCTION METHOD THEREOF

OSAKA Titanium technologi...

1. A Li-containing silicon oxide powder for use in a negative electrode material of a lithium ion secondary battery, with the Li-containing silicon oxide powder undergoing Li-doping, the Li-containing silicon oxide powder exhibiting peaks observed by X-ray diffractometry using CuK? ray that include a height of peak attributed to Li2Si2O5, P1, exhibited at a diffraction angle 2? ranging from 24.4 to 25.0°; a height of peak attributed to Li2SiO3, P2, exhibited at a diffraction angle 2? ranging from 18.6 to 19.2°; and a height of peak attributed to crystalline Si, P3, exhibited at a diffraction angle 2? ranging from 27.4 to 29.4°, which fulfill Requirement (1): P2/P1<1 and P3/P1<0.5.

US Pat. No. 10,427,942

GRAPHENE DISPERSION PASTES, METHODS OF PREPARING AND USING THE SAME

ENERAGE INC., Wujie Town...

1. A method of preparing a graphene dispersion paste, comprising:mixing and stirring graphene sheets, a solvent and a polymer to form a pseudo-plastic non-Newtonian fluid, wherein each of the graphene sheets is consisting of 2 to 30 stacked graphene layers, and has a bulk density in a range from 0.005 to 0.05 g/cm3, a thickness in a range from 0.68 to 10 nm, and a lateral size in a range from 1 to 100 ?m; and
applying a pressure not less than 10 bar to the pseudo-plastic non-Newtonian fluid, allowing the pseudo-plastic non-Newtonian fluid pass through a slit of a clearance not greater than 1,000 ?m at least two times, then forming a graphene dispersion paste, wherein a viscosity of the pseudo-plastic non-Newtonian fluid passing through the slit is in a range from 10 to 10,000 cps, and a viscosity of the graphene dispersion paste is in a range from 50,000 to 350,000 cps.

US Pat. No. 10,427,937

METHOD FOR PRODUCING A MULTILAYER MEMS COMPONENT, AND CORRESPONDING MULTILAYER MEMS COMPONENT

Robert Bosch GmbH, Stutt...

1. A method for manufacturing a multi-layer MEMS component, the method comprising:providing a multi-layer substrate that includes a monocrystalline carrier layer, a monocrystalline functional layer with a front side and a back side, and a bonding layer located between the back side and the carrier layer;
growing a first polycrystalline layer over the front side of the monocrystalline functional layer;
removing the monocrystalline carrier layer; and
growing a second polycrystalline layer over the back side of the monocrystalline functional layer.

US Pat. No. 10,427,934

THERMAL MANAGEMENT USING MICROELECTROMECHANICAL SYSTEMS BIMORPH CANTILEVER BEAMS

United States of America ...

1. A cooling structure for a heat source, the cooling structure comprising:a plurality of beams having a first end and terminating at a second end, the plurality of beams having a plurality of different lengths defined between the first and second ends, each beam formed at least in part of a first conducting material having a first thermal coefficient of expansion and a second conducting material having a second thermal coefficient of expansion, where the first thermal coefficient of expansion is different from the second thermal coefficient of expansion,
the first end of each beam thermally connected to the heat source, such that heat generated by the heat source is conducted along the length of the beam to the second end of each beam,
where the heat conducted through each beam causes each beam to deflect as the first and second materials expand differently due to the difference in the first and second thermal coefficients of expansion,
where characteristics of each beam are selected such that the second end of each beam makes thermal contact with a heat sink as a temperature of the heat source increases, the beam thereby conducting heat away from the heat source to the heat sink and assisting to lower the temperature of the heat source;
wherein the heat source and the heat sink are connected to a substrate and the beam extends across the substrate between the heat source and the heat sink; and
wherein the plurality of beams include a first plurality of beams positioned at an intermediate location of the cooling structure, a second plurality beams and a third plurality of beams positioned on either side of the first plurality of beams, and wherein the second and third plurality of beams are shorter in length relative to the first plurality of beams.

US Pat. No. 10,427,933

MICROELECTROMECHANICAL SENSOR DEVICE WITH REDUCED STRESS-SENSITIVITY AND CORRESPONDING MANUFACTURING PROCESS

STMicroelectronics S.r.l....

1. A process for manufacturing a MEMS device, the process comprising:coupling a sensor wafer to a supporting wafer, the sensor wafer including semiconductor material and including a sensor die integrating a micromechanical detection structure and a sensor frame;
separating the sensor die from the sensor frame, the sensor frame being arranged around the sensor die;
after separating the sensor die from the sensor frame, electrically and mechanically coupling at least one conductive element to the sensor die and the sensor frame, wherein the sensor frame supports the sensor die only by the at least one conductive element;
coupling a cap wafer to a surface of the sensor frame; and
mechanically decoupling the sensor die from the supporting wafer.

US Pat. No. 10,427,932

HERMETICALLY SEALED MEMS DEVICE AND ITS FABRICATION

TEXAS INSTRUMENTS INCORPO...

1. A hermetic package, comprising:a substrate having a surface;
a microelectromechanical system (MEMS) structure on the surface, the MEMS structure having a first height;
a cap hermetically sealed to the substrate, the cap forming a cavity over the MEMS structure; and
a vertical stack of metal layers adhering to the surface and to the cap, the cap attached to the surface by the stack, the stack having a continuous outline surrounding the MEMS structure while spaced from the MEMS structure by a distance, and the stack having: a first bottom metal seed film adhering to the substrate; a second bottom metal seed film adhering to the first bottom metal seed film, the first and second bottom metal seed films having a first width and a first common sidewall; a first top metal seed film adhering to the cap; a second top metal seed film adhering to the first top metal seed film, the first and second top metal seed films having a second common sidewall and a second width smaller than the first width; and a metal layer including gold-indium intermetallic compounds, the metal layer encasing the first and second bottom metal seed films and the first and second top metal seed films and the first and second common sidewalls and having a second height greater than the first height.

US Pat. No. 10,427,929

FORMING A EUTECTIC BOND BETWEEN A WAFER HAVING AN ANTI-STICTION COATING AND A CAP WAFER

NXP USA, Inc., Austin, T...

1. A method comprising:providing a first semiconductor substrate;
forming a metal layer over the first semiconductor substrate;
forming an anti-stiction coating layer on the metal layer;
providing a second semiconductor substrate;
forming a roughened germanium layer over the second semiconductor substrate, wherein said forming the roughened germanium layer comprises:
forming polycrystalline silicon clusters over the second semiconductor substrate;
depositing a first layer comprising silicon and germanium over the polycrystalline silicon clusters; and
depositing a second layer comprising germanium over the first layer;
contacting the roughened germanium layer to the anti-stiction coating layer; and
after contacting the roughened germanium layer to the anti-stiction coating layer,
applying sufficient pressure to the second semiconductor substrate for at least a portion of the roughened germanium layer to penetrate the anti-stiction coating layer and come into contact with the metal layer, and
forming a mechanical bonding material between the first substrate and the second substrate, wherein
the forming a mechanical bonding material includes applying heat to the roughened germanium layer and the metal layer, and
the bonding material comprises a metal of the metal layer and germanium of the germanium layer.

US Pat. No. 10,427,927

METHOD FOR FILLING A CONTAINER WITH A LIQUID

Leibinger GmbH, Teningen...

1. A method for filling a bottle with a liquid, the method comprising:providing a cap comprising an axial through bore and a radial opening that extends in a radial direction through the cap, the radial opening having a radial inward end opening into the axial through bore and further having a radial outward end;
providing a balloon body that is liquid-tight relative to the liquid and gas-tight, the balloon body extending through the axial through bore, the balloon body comprising an upper circumferential rim, wherein the balloon body is connected seal-tightly to the cap with the upper circumferential rim above the radial inward end of the radial opening, and the balloon body further having a balloon bottom end extending downwardly away from the cap;
providing an elongate support associated with the balloon body and connected to the cap;
inserting the balloon bottom end and the elongate support into the bottle through a container opening of the bottle;
positioning the cap in a first position at a spacing above a top face of a rim of the container opening so that a ring-shaped intermediate gap is defined between a bottom side of the cap and the top face;
inflating the balloon body with an expansion medium until the balloon body fills out an interior of the bottle to thereby force out air contained in the interior of the bottle through the ring-shaped intermediate gap;
subsequently fluid-tightly fitting the cap in a second position on the top face of the container opening;
creating an intermediate space between an outer surface of the balloon body and an inner wall of the bottle by allowing the expansion medium to escape from the balloon body;
supplying the liquid through the radial opening and through the axial through bore into the intermediate space.

US Pat. No. 10,427,925

VEHICLE WITH A ROTARY CONTROL BOX AND AERIAL WORK PLATFORM

ZHEJIANG DINGLI MACHINERY...

1. A vehicle with a hinged control box, comprising: a vehicle frame, a driving system disposed on the vehicle frame, and the control box; wherein the control box is hinged on a lateral side of a base of the vehicle frame; the control box is electrically connected with the driving system; a casing is disposed in the lateral side of the base; an opening is defined on a lateral side of the casing for turning the control box into and out of the casing; and an edge of the control box is hinged to an upper edge of the opening, such that the pivot axis of the door is above the opening.

US Pat. No. 10,427,922

Z-DRIVE SHIPPING LOCK FOR STORAGE LIBRARY ROBOTIC ASSEMBLY

ORACLE INTERNATIONAL CORP...

1. A locking subsystem of a drive assembly, comprising:a spring-loaded ratchet pawl comprising a portion thereof movable between at least first and second pawl positions, wherein the spring-loaded ratchet pawl ratchet pawl is configured to be disengaged from between adjacent gear teeth of the drive assembly when in the first pawl position to allow rotational movement of the drive assembly in both of first and second opposing rotational directions, wherein the spring-loaded ratchet pawl ratchet pawl is configured to engage between adjacent gear teeth of the drive gear of the drive assembly in the second pawl position to disallow rotational movement of the drive assembly in the first rotational direction and allow rotational movement of the drive assembly in the opposing second rotational direction, wherein the spring-loaded ratchet pawl is in a first state of deflection in the first pawl position, wherein the spring-loaded ratchet pawl is in a second state of deflection in the second pawl position, and wherein the second state of deflection is less than the first state of deflection;
a handle movable between at least first and second handle positions; and
a cam member rigidly secured to the handle and movable between the first and second handle positions, wherein the cam member urges the spring-loaded ratchet pawl into the first pawl position in the first handle position, and wherein the spring-loaded ratchet pawl moves into the second pawl position in the second handle position.

US Pat. No. 10,427,921

SLACK LINE DETECTION SYSTEMS FOR WINCHES

Ingersoll-Rand Company, ...

1. A winch comprising:a first end frame and a second end frame;
a drum located between and rotatably coupled to the first and second end frames and configured to rotate to wind or unwind a cable;
a brake configured to resist rotation of the drum when engaged;
a switch configured to cause the brake to engage the drum when the switch is activated;
a slack arm frame engaging the cable and including a first lever arm and a second lever arm, the first lever arm pivotally coupled to the first end frame and the second lever arm pivotally coupled to the second end frame, wherein the slack arm frame is configured to pivot between a first position when the cable is taut and a second position when the cable is slack;
a cam having an arcuate camming surface coupled to the slack arm frame and the first end frame, with the first end frame located between the slack arm frame and the cam;
a mounting bracket coupling the switch to the first end frame, wherein the mounting bracket is adjustable between a plurality of locations on the first end frame by loosening and tightening a single fastener, each of the plurality of locations positioning the switch at a different distance from the axis;
a first drop stop attached to the first lever arm and extending toward the first end frame, the first drop stop being configured to directly contact the first end frame when the slack arm frame pivots from the first position to the second position to prevent further pivoting of the slack arm frame.

US Pat. No. 10,427,920

METHOD OF DETECTING A WORN LINK IN A CHAIN, AND A HOIST ARRANGEMENT

1. A method of detecting a worn link in a chain of a hoist arrangement operated with an electric drive system, the method comprising the step of:measuring a first signal of the electric drive system of the hoist arrangement while driving the hoist and detecting a peak crossing of a certain threshold level in the measured first signal, said peak in the measured first signal representing the worn link in the chain,
said method further comprising at least one of the following:
that the measured first signal is a load signal of the electric drive system of the hoist and peaks above a certain threshold level are detected; and that
the measured first signal is a speed signal of the electric drive system of the hoist and peaks crossing a certain threshold level are detected.

US Pat. No. 10,427,919

APPLICATION AND METHOD FOR POSITIONING AND ORIENTATING A LOAD

1. An apparatus for positioning and orientating a load, the apparatus comprising:a support structure movable in a first direction, the support structure establishes an area within which the load can be positioned and orientated;
a tendon system comprising:
at least six winches directly mounted on the support structure; and
at least six tendons, a first end of each of the at least six tendons being connected to a respective one of the at least six winches;wherein the apparatus further comprises:a lifting mechanism mounted on the support structure and movable in a second direction which is perpendicular to the first direction, the lifting mechanism comprising a further tendon;
attachment means whereto the load is attachable to suspend from above, the attachment means being connected to a second end of each of the at least six tendons and to a free end of the further tendon; and,
a control module being capable of synchronously and independently operating:
over the at least six winches so as to adjust the free length of and/or tension supported by the tendon connected to the respective winch,
the support structure so as to control its movement in the first direction, and
the lifting mechanism so as to control its movement in the second direction and the lifting mechanism so as to adjust the free length of and/or tension supported by the further tendon connected to the lifting mechanism,
whereby the apparatus provides control of the load in the six degrees of freedom; wherein the control module is configured to translate an instruction regarding the orientation and/or the position of the load in an actuation of the at least six winches, of the lifting mechanism and of the support structure, such that at least 51% of the load is sustained by the lifting mechanism and the load is suspended from the further tendon which is substantially vertical.

US Pat. No. 10,427,917

MEANS CONCERNING HOOK

SUBSEA TOOLPOOL NORD AS, ...

1. A lifting hook for securing a load comprising:a connecting ring,
a shaft,
a hook having a hook tip and a shank, the hook tip and the shank being spaced apart to define a hook opening,
a closing system including a closing lip biased to a first position to block the hook opening, and a release mechanism having a handle operable to move the closing lip to a position where the hook opening is not blocked, the bias of closing system operable to return the closing lip to the first position, and
a support assembly including a sliding assembly having a position lock assembly,
wherein the position lock assembly includes a push lock rod, a tension spring, a threaded cap, and a handle, the push lock rod engageable with lock down holes formed in the shaft of the hook to positively lock the sliding assembly.

US Pat. No. 10,427,916

STRUCTURE INSTALLATION SYSTEM WITH VEHICLE HAVING HANGERS TO SUPPORT A WALL

TGR Construction, Inc., ...

1. A structure installation system, comprising:a vehicle adapted to traverse a ground surface, wherein the vehicle includes:
an arm extending from the vehicle;
an arm coupler connected to the arm;
a plurality of wheels or a plurality of tracks connected to a motor;
a wall adapted to be installed in the ground surface, wherein the wall comprises a bollard wall including a plurality of vertical beams defining a plurality of slots;
a support connected to the arm of the vehicle, wherein the support is connected to the arm coupler, wherein the support is rotatable about at least one axis with respect to the arm of the vehicle, wherein the support comprises an upper end and a lower end;
a plurality of hangers connected to the support, wherein the wall is removably connected to the hangers, wherein the support is adapted to retain the wall in a desired position and orientation with respect to the ground surface during installation of the wall in the ground surface.

US Pat. No. 10,427,915

METHOD FOR CONTROLLING A TRANSPORT DEVICE, NAMELY AN ESCALATOR OR A MOVING WALKWAY

THYSSENKRUPP ELEVATOR INN...

1. A method for controlling a transportation device with a control unit, the transportation device including a transport area for accommodating a person to be transported, transport means adapted for conveying the person in the transport area in a standing manner, drive means adapted for driving the transport means, and an image recording device for generating visual images of a sector of the transport area, the method comprising:generating with the image recording device the visual images, which include a sequence of at least two visual images of the person traveling in the transport area;
analyzing a movement of the person within the transport area based on the visual images by filtering pixels of a representation of the person and analyzing an optical flow of the pixels; and
transferring the control unit into a safety modus based on the analysis of the movement of the person.

US Pat. No. 10,427,912

ELEVATOR SYSTEM

THYSSENKRUPP ELEVATOR AG,...

1. An elevator system comprising:a support rope;
an elevator cage that is suspended from the support rope and displaceable in an elevator shaft;
a suspension disposed on the elevator cage;
a connection means that has a first end and a second end, wherein the first end is closer to the elevator cage than the second end and is immovably fixed to the suspension on the elevator cage; and
a support unit that is positioned at least partially outside a vertical projection of the elevator cage, wherein the support unit comprises an additional rope that is fastened to the suspension, such that the support unit exerts a first force on the suspension, which first force counteracts a second force acting on the suspension, wherein the second force acts downwards and is attributable to a weight of the connection means,
wherein the additional rope is fastened to the suspension in a position outside the vertical projection of the elevator cage.

US Pat. No. 10,427,911

DAMPER UNIT FOR AN ELEVATOR

INVENTIO AG, Hergiswil N...

1. A damper unit for an elevator, the damper unit being arranged on an elevator car of the elevator for reducing vibrations of the elevator car during a standstill, comprising:an acting element, in an idle position, being spaced apart from a guide rail of the elevator, the acting element, in an active position, being connected slip-free to the guide rail; and
force transmitting elements attached to the acting element for damping movements of the elevator car in the active position of the acting element to reduce vibrations of the elevator car, where the force transmitting elements include a ram that extends in a horizontal direction with a free end on which the acting element is arranged, and the force transmitting elements further include at least one shock damper hinged to a housing, wherein in the idle position the at least one shock damper is transversely oriented to the ram, and the at least one shock damper is configured to attenuate vertical vibrations of the elevator car through changes in length.

US Pat. No. 10,427,910

DISPLAY LANGUAGE ARRANGEMENT

Kone Corporation, Helsin...

1. A method for applying user preferences for at least one public display comprising:detecting at least one mobile device in a vicinity of said at least one public display;
establishing communication between said at least one public display and said at least one mobile device, said communication being established using one or more signals having a communication range covering at least an area in which content output by said at least one public display is visible;
receiving at least one indication of at least one user preference from each of said at least one mobile device by
receiving an identification from said at least one mobile device,
transmitting a request to a server storing one or more user preferences in association with said identification, and
receiving said at least one indication of said at least one user preference as a response to said request;
determining at least one user preference for said at least one public display based on said at least one indication; and
applying said determined at least one user preference to said at least one public display, said at least one user preference including a preferred language of operation, and said at least one indication received from each of said at least one mobile device indicating more than one language of operation in order of preference.

US Pat. No. 10,427,909

USER-CONTROLLED ELEVATOR ALLOCATION FOR INDEPENDENT SERVICE

OTIS ELEVATOR COMPANY, F...

1. A system for allocating elevator use based on an individual request, the system comprising:a request module that receives a reservation request of an elevator car from a user;
an allocation module that identifies a reserved elevator car based on the reservation request; and
a mechanical control module that moves the reserved elevator car in response to commands provided by the user and the reservation request;
wherein the reservation request specifies a time parameter for reservation request, the time parameter including at least one of a day and a time the reserved elevator car is requested;
wherein the reservation request includes a location where the reserved elevator car is desired;
the reservation request specifies an independent service that dedicates a reserved elevator car for operation by the user.

US Pat. No. 10,427,908

EMERGENCY MODE OPERATION OF ELEVATOR SYSTEM HAVING LINEAR PROPULSION SYSTEM

OTIS ELEVATOR COMPANY, F...

1. A method, comprising:detecting, by an elevator controller, a fault within an elevator system;
utilizing, by the elevator controller, the fault to disable a drive control portion of the elevator controller and activate a drive urgent stop control portion of the elevator controller;
generating, by the drive urgent stop control portion of the elevator controller, a signal based on at least one of a speed estimation, a velocity profile, and feedforward information; and
applying, by the elevator controller, the signal to an inverter connected to a linear propulsion system to execute the urgent stop of an elevator car of the elevator system;
the linear propulsion system comprising a primary portion including a plurality of coils configured to receive power from the inverter and a secondary portion including permanent magnets, one of the primary portion and the secondary portion mounted to the elevator car.

US Pat. No. 10,427,906

MODULAR SECTIONS FOR TEMPORARY TURNTABLE APPLICATIONS

BBM Railway Equipment, LL...

1. A turntable comprising:a hub defining a first rotation axis;
a base including a plurality of rolling supports that each rotate about one of a plurality of axes of rotation perpendicular to said first rotation axis, said base including a plurality of base sections;
a rotating member secured to said hub such that a center of said rotating member aligns with the first rotation axis, said rotating member including a plurality of sections;
a first one of said plurality of base sections disposed radially around said hub and including a first set of the plurality of rolling supports;
a first one of said plurality of sections is coupled to the hub that defines a center of said rotating member, said first one of said plurality of sections supported by the first set of the plurality of rolling supports and defining a first radius;
a second one of said plurality of base sections removably secured radially outwards of said first base section and including a second set of the plurality of rolling supports; and
a second section removably secured around said first section and supported at least in part by said second set of the plurality of rollers to define a second radius greater than the first radius.

US Pat. No. 10,427,905

ACCUMULATION DEVICE

Fuji Seal International, ...

1. An accumulation device, comprising:an infeed unit configured to feed in a substrate;
an outfeed unit configured to feed out the substrate;
a tensioning unit disposed toward upstream in a transporting direction of the substrate between the infeed unit and the outfeed unit, the tensioning unit being configured to apply predetermined tensile force to the substrate;
an accumulation unit disposed downstream of the tensioning unit in the transporting direction of the substrate between the infeed unit and the outfeed unit, the accumulation unit being configured to accumulate a surplus of the substrate generated by a difference between a substrate infeed rate of the infeed unit and a substrate outfeed rate of the outfeed unit; and
a controller configured to control an operation of each of the infeed unit, the outfeed unit, and the accumulation unit,
wherein
the tensioning unit includes a plurality of rotatable fixed rollers spaced from each other and arranged in parallel to each other, and at least one rotatable movable roller disposed in parallel to the fixed rollers, the at least one rotatable movable roller being movable toward and away from the fixed rollers, the substrate being transported while being wound alternately around the fixed rollers and the at least one movable roller,
the tensioning unit is configured to apply the predetermined tensile force to the substrate by a force acting onto the movable roller in a direction away from the fixed rollers, and
the controller is configured to maintain a constant position of the movable roller with respect to the fixed rollers of the tensioning unit.

US Pat. No. 10,427,904

METHOD FOR PRODUCING FILM AND METHOD FOR WINDING OFF FILM

SUMITOMO CHEMICAL COMPANY...

1. A method for producing a film, said method comprising the steps of:taking up a film by a first step of winding the film on an outer peripheral surface of a core while oscillating the core in a rotation axis direction, such that the film is in a state of being distorted in a wavelike manner in the rotation axis direction; and
a second step of winding off the film, which has been taken up in the taking up step and which is in the state of being distorted in the wavelike manner in the rotation axis direction, from the core,
wherein in the second winding off step, the core is oscillated in the rotation axis direction and in the second winding off step, oscillation of the core is controlled so that distortion of the film which has been wound off becomes smaller.

US Pat. No. 10,427,903

LEADING EDGE DEVICE FOR A SURFACE WINDER

1. An improvement to a surface winder for winding a web material around a core having a radius, R, to obtain a log, the surface winder comprising a glue applicator for dispensing glue onto said core, a core inserter for transporting and inserting said core provided with said glue disposed thereon into a winding cradle defined at a top by an upper winding roller, supplied from above with said web material directed towards said winding cradle at a velocity, v, and at a bottom by a concave cradle associated downstream to a lower winding roller, said surface winder comprising a third oscillating roller arranged above said lower winding roller, said upper winding roller, said lower winding roller, and said third oscillating roller each having a respective axes parallel to each other and perpendicular to the feeding direction of said web material and cooperating with each other downstream of said winding cradle in order to wind said web material around said core to obtain said log, said concave cradle comprising an introductory portion, the improvement comprising:wherein said introductory portion of said concave cradle comprises a leading edge device, said leading edge device having a surface for contacting said core, said surface having a texture with protuberances provided thereto.

US Pat. No. 10,427,899

HIGH SPEED AUTOMATED FEEDING SYSTEM AND METHODS OF USING THE SAME

1. A system for separating and feeding tray-packed items individually, comprising:a. a collection station for removing a row of pre-packaged items from a package;
b. a transfer shuttle operable to grasp each end of the row and transport the row to a feeder magazine; and
c. a feeder magazine having a track for receiving the row of pre-packaged items, a driving mechanism for advancing the row of pre-packaged items through the track, and picking station operable to perform a picking operation which removes said pre-packaged items individually from said feeder magazine, comprising:
i. an arresting mechanism for preventing the advancement of the row of pre-packaged items,
ii. a stop tab operable to hold a leading pre-packaged item in said feeder magazine, and
iii. a picking mechanism operable to remove said leading pre-packaged item from said feeder magazine and deliver said leading pre-packaged item to a backend conveying system or a container,wherein said system is operable to perform said picking operation in repetition to separate said pre-packaged items and deliver them individually to said backend conveying system or said container, and said arresting mechanism is operable to arrest the advancement of said pre-packaged items during a picking operation by applying pressure to a plurality of said pre-packaged items and disengage from said plurality of said pre-packaged items between picking operations.

US Pat. No. 10,427,898

SHEET TRANSFER APPARATUS AND METHOD FOR TRANSFERRING SHEET USING THE SAME

Samsung Display Co., Ltd....

1. A sheet transfer apparatus comprising:a table on which two or more sheets, which are continuously laminated, are configured to be seated;
a sheet adsorbing part over the table to adsorb a first sheet, which is at an uppermost portion, of the two or more laminated sheets at a pressure;
an air discharge part over the table and adjacent to the sheet adsorbing part; and
an elevation unit configured to vertically elevate the sheet adsorbing part and the air discharge part,
wherein the elevation unit comprises:
a support part having a long side extending in a first direction and a short side extending in a second direction crossing the first direction; and
an elevation part configured to vertically elevate the support part,
wherein the air discharge part is configured to discharge air in a downward direction onto a surface of the first sheet adsorbed to the sheet adsorbing part.

US Pat. No. 10,427,897

PICKUP ROLLER HAVING FRONT END ALIGNMENT MEMBER AND MEDIUM SEPARATING DEVICE USING SAME

NAUTILUS HYOSUNG INC., S...

1. A pick-up roller provided in a media separation apparatus and configured to pick up stacked media sheets one by one and transfer a picked-up media sheet into a space between a feed roller and a separation roller, the pick-up roller comprising:a pick-up roller body configured to rotate;
a front-edge alignment element provided on an outer circumferential surface of the pick-up roller body, and comprising a band-shaped elastic sheet protruding in a curved shape outward from the pick-up roller body and configured to come into contact with a media sheet and align a front edge of the media sheet to a position of an entrance between the feed roller and the separation roller; and
a pick-up element provided on a portion of the outer circumferential surface of the pick-up roller body at a position opposite to the front-edge alignment element, and including a contact part protruding outward from the pick-up roller body and configured to come into contact with the media sheet, pick up the media sheet using a frictional force, and transfer the media sheet into the space between the feed roller and the separation roller,
wherein the pick-up roller body includes a first section an outer circumferential surface of which has an overall arc shape, and a second section an outer circumferential surface of which is relatively planar compared to the outer circumferential surface of the first section,
wherein the pick-up element is provided on the circumferential surface of the first section, and the front-edge alignment element is provided on the circumferential surface of the second section, and
wherein the front-edge alignment element is bonded to the second section of the pick-up roller body through a bonding process using an adhesive or a thermosetting bonding process.

US Pat. No. 10,427,896

IMAGE FORMING APPARATUS

Brother Kogyo Kabushiki K...

1. An image forming apparatus, comprising:an image forming unit;
a first casing that houses the image forming unit therein;
a second casing;
a document cover; and
a lock mechanism;
wherein the second casing comprises:
a document support surface located at an upper surface of the second casing; and
a positioning column protruding upward relative to the document support surface,
wherein the second casing is connected to the first casing, disposed above the first casing, and configured to pivot between a first position in which the second casing covers an upper surface of the first casing, and a second position in which the second casing reveals the upper surface of the first casing,
wherein the document cover is connected to the second casing, disposed above the second casing, and configured to pivot between a third position in which the document cover covers the document support surface, and a fourth position in which the document cover reveals the document support surface,
wherein the document cover has a positioning recess, in which the positioning column of the second casing fits when the document cover is at the third position,
wherein the lock mechanism comprises:
a fixed hook disposed at the first casing;
a movable hook disposed in the second casing;
a pressed portion configured to move in association with the movable hook; and
an actuator disposed in the positioning recess;
wherein the positioning column has a cutout portion configured to receive the pressed portion,
wherein when the second casing is at the first position and the document cover is at the fourth position, the pressed portion is located in the cutout portion and the movable hook is engaged with the fixed hook, and
wherein when the second casing is at the first position and the document cover is at the third position, the positioning column fits in the positioning recess, and the actuator contacts the pressed portion, thereby disengaging the movable hook from the fixed hook.

US Pat. No. 10,427,894

MODULE CONNECTOR, MODULAR CONTAINER, AND SEALING ELEMENT THEREFOR

Volkmann GmbH, Soest (DE...

1. A module connector for connectinga first container module having a first flange with a first flange surface,
to a second container module having a second flange with a second flange surface,
wherein the container modules being joined together have an aligned, especially a flush, container inner surface,wherein a first seal is arranged between the first container module and the second container module,wherein a second seal is arranged between the first container module and the second container module,wherein the first seal is arranged in a recess and the second seal in a groove,wherein preferably the first seal forms an inner sealing with respect to the container and wherein preferably the second seal forms an outer sealing with respect to the container,wherein the second, preferably outer seal produces a sealing of the interconnected container modules especially if the first, preferably inner seal fails or at least has a leak,wherein the first seal has at least one crimp region, which when the first flange is arranged at or on the second flange is crimped by the first and/or the second flange surface, preferably by the first flange surface, such that one end face of the first seal is situated flush and/or aligned with the container inner surface and without forming a cavity in the area of the end face of the first seal.

US Pat. No. 10,427,893

HANDLING DEVICE AND BENDING INSTALLATION AND METHOD FOR BENDING A PART TO BE BENT

RAS Reinhardt Maschinenba...

1. Handling device for inserting parts to be bent into a bending device for the bending thereof about at least one bending edge, the handling device has a holding unit which is formed to be elongate in a longitudinal direction and has at least one holding element with which the part to be bent, which is to be received and is arranged on a loading surface, is grippable on one of its flat sides by forces of attraction on one side of the flat side at a plurality of successive locations in the longitudinal direction, the holding unit being pivotable relative to a pivoting carrier unit about a first pivot axis parallel to the longitudinal direction, the pivoting carrier unit is pivotable relative to a pivoting carrier base about a second pivot axis which extends parallel to the first pivot axis, the pivoting carrier unit has at least two pivot arms extending to the first pivot axis, the at least two pivot arms are in spaced relation to define a longitudinal span with the at least one holding element being arranged longitudinally within said longitudinal span of the at least two pivot arms, the pivoting carrier base is movable by means of a carrier base moving unit in a direction transverse to the second pivot axis, and, with the handling device, the part to be bent is movable between a receiving position for the part to be bent on the loading surface and a bending device insertion position for the part to be bent.

US Pat. No. 10,427,892

MECHANISM FOR SUPPLYING MOSAIC TILE TO AN AUTOMATED TILE SETTER

CAPITAL ONE SERVICES, LLC...

11. A system for supplying mosaic tiles to an automated mosaic tile setter, the system comprising:a first pick-and-place robot configured for loading mosaic tiles into hoppers, the mosaic tiles comprising a plurality of characteristics;
a first controller operatively connected to the first pick-and-place robot and programmed to control the first pick-and-place robot to:
automatically load the mosaic tiles into the hoppers on one of a last-in, first-out basis, or a last-in, last-out basis; and
synchronize the automatic loading with an optimized ordering of the mosaic tiles, based on a desired pattern of a mosaic tile arrangement;
a second pick-and-place robot configured to pick and place the loaded mosaic tiles from the hoppers; and
a second controller operatively connected to the second pick-and-place robot and programmed to control the second pick-and-place robot to:
pick the mosaic tiles from the hoppers; and
place the mosaic tiles onto sheets of underlayment material in arrangements that form sections of the mosaic tile arrangement.

US Pat. No. 10,427,891

TRANSFER GUARD SYSTEM AND MOUNT THEREOF

Flexible Steel Lacing Com...

1. A transfer guard system comprising:an elongated mounting member for extending laterally across a gap between conveying surface portions;
at least one transfer guard member configured to be connected to the mounting member to transfer objects across the gap in a downstream longitudinal direction;
a pair of adjustable mounts configured to connect the mounting member to conveyor structure, the adjustable mounts having an installation configuration that permits adjustment of an operating position of the mounting member to a plurality of different operating positions and an operating configuration that secures the mounting member in the selected position; and
support members of each of the adjustable mounts configured to be movable between a plurality of angular orientations relative to each other and a plurality of positions relative to each other with the adjustable mount in the installation configuration and configured to be fixed relative to each other with the adjustable mount in the operating configuration.

US Pat. No. 10,427,888

ON-LINE WHEEL TRANSFER MECHANISM

Citic Dicastal Co., Ltd.,...

1. An on-line wheel transfer mechanism, comprising: a first roller bed, a cylinder, a base, a linear guide rail, a rack, a guide rail seat, a first rotating shaft, first bearing seats, a gear, first rotating arms, second bearing seats, a second rotating shaft, a third rotating shaft, second rotating arms, brackets, a fourth rotating shaft and a second roller bed, wherein the cylinder, the first bearing seats and the linear guide rail are mounted on the base, the rack is connected to the linear guide rail through the guide rail seat, an output shaft of the cylinder is connected to the rack, and the first rotating shaft is mounted on two of the first bearing seats which are arranged symmetrically; the gear and two of the first rotating arms are respectively symmetrically fixed on the first rotating shaft, the rack is engaged with the gear, the second rotating shaft is mounted on two of the second bearing seats which are arranged symmetrically, two of the second rotating arms are respectively symmetrically fixed on the second rotating shaft, the first rotating arms are hinged to the brackets through the third rotating shaft, and the second rotating arms are hinged to the brackets through the fourth rotating shaft.

US Pat. No. 10,427,886

APPARATUS AND PROCESS FOR ROTATING PRODUCTS

1. An apparatus for rotating at least one rolled product, the apparatus comprising:a. at least one conveyor on which is conveyed at least one rolled product in a machine direction;
b. a rotator assembly moveably attached via a reciprocating linkage to a framework, the rotator assembly being driven by a first motor such that the rotator assembly cycles in a closed path in a vertical plane;
c. the rotator assembly having mounted to the linkage a second motor having a rotator cup, the framework being positioned with respect to the conveyor such that upon each cycle of the rotator assembly the rotator cup cycles close enough to the conveyor such that it can contact the rolled product throughout part of the cycle;
wherein the rotator cup comprising flanges and a distance between the flanges is adjustable.

US Pat. No. 10,427,885

ARTICLE SUPPLY METHOD AND DEVICE

Kurashiki Boseki Kabushik...

1. An article supply method using a movable block capable of a reciprocal movement between a first position and a second position, comprising:introducing one conveyed object into a housing portion formed on the movable block when the movable block is in the first position;
moving the movable block from the first position to the second position by pressurizing the movable block from a first position side of a movable area for a predetermined time to push the movable block while vacuum-sucking the movable block from a second position side of the movable area of the movable block, and then continuing the vacuum suction from the second position side;
discharging the conveyed object from the housing portion when the movable block is in the second position; and
returning the movable block from the second position to the first position by vacuum-sucking the movable block from the first position side to move the movable block to the first position.

US Pat. No. 10,427,883

MULTI-DRIVE CONVEYOR SYSTEMS AND METHODS OF USING SAME

FEDEX CORPORATION, Memph...

1. A conveyor system for advancing an item relative to a transport axis, the conveyor system comprising:a conveyor belt; and
a modular drive assembly comprising:
at least one drive module, each drive module having a housing and a pulley assembly positioned within the housing, wherein the pulley assembly of each drive module is configured to engage the conveyor belt and drive movement of the conveyor belt along a conveyor movement pathway; and
at least one take-up module, each take-up module having a housing and a pulley assembly positioned within the housing, wherein the pulley assembly of each take-up module is configured to engage the conveyor belt and provide tension to the conveyor belt as the conveyor belt moves along the conveyor movement pathway,
wherein respective positions of the housings of the at least one drive module and the at least one take-up module relative to the transport axis are selectively adjustable to modify the conveyor movement pathway.

US Pat. No. 10,427,882

CONVEYOR BELT SUPPORT SYSTEM

John Bean Technologies Co...

1. A conveyor belt support system for a conveyor having a belt movable along a frame, the conveyor belt support system comprising a plurality of support slats extending substantially along a longitudinal axis of the belt and each defining a support surface against which the belt moves, and wherein each of the plurality of support slats is moveable in at least a first direction to correspondingly move the belt in the first direction and in a second direction to correspondingly move the belt in the second direction to provide a substantially level sliding plane for the belt.

US Pat. No. 10,427,881

CONVEYOR CHAIN MODULE

1. A module for a modular conveyor chain, said module comprising:a metal link portion including a substantially elongate conveying body having opposing longitudinal sides and a bottom face;
a central hinge loop on one longitudinal side of the conveying body; and
a pair of offset hinge loops on the opposite longitudinal side of the conveying body, said pair of offset hinge loops being interspaced to receive the central hinge loop of a link portion of a consecutive module therebetween, wherein each of the hinge loops of the conveying body extend from the conveying body and loop with their free ends back towards the bottom face of the conveying body around a hinge receiving space, so that consecutive modules can be hingedly coupled by a hinge pin passing axially through aligned hinge receiving spaces of cooperating hinge loops, wherein the central hinge loop or each of the offset hinge loops of the pair of offset hinge loops define a distance between the hinge loop free end and the bottom face of the conveying body to form a through pass aperture through which a hinge pin having a diameter over at least a part of its length in the range between about 4 mm to about 8 mm held in a hinge receiving space of at least one hinge loop of another module may pass substantially transversely to its axis into or out of the hinge receiving space of the central hinge loop or each of the offset hinge loops of the pair of offset hinge loops.

US Pat. No. 10,427,880

SNAP-ON POSITION LIMITER FOR A CONVEYOR BELT

Laitram, L.L.C., Harahan...

1. A shaft for mounting components in a conveyor frame, comprising:an axial member extending from a first end to a second end;
a channel extending longitudinally along at least a portion of the axial member perimeter for receiving a tip of a conveyor component; and
a slot in an end face of the shaft for receiving a pin on a handle to selectively shift the shaft relative to the conveyor frame.

US Pat. No. 10,427,879

CONVEYOR STRUCTURE

Jia-Tian Lin, Changhua (...

1. A conveyor structure of an agricultural machine, the conveyor structure comprising:a first conveyor structure layer;
a core structure layer disposed on the first conveyor structure layer, and comprising:
a rope layer disposed on the first conveyor structure layer, and comprising a plurality of warp ropes;
a cloth layer disposed on the rope layer;
a plurality of first wefts; and
a plurality of second wefts, wherein the plurality of first wefts and the plurality of second wefts are obliquely intertwined with each other and wrapped on the rope layer, or on the cloth layer, or on the rope layer and the cloth layer; and
a second conveyor structure layer disposed on the core structure layer;
a plurality of fastening members disposed on the conveyor structure and penetrating the first conveyor structure layer and the second conveyor structure layer, wherein portions of the core structure layer not penetrated by the plurality of fastening members providing a support force to the first conveyor structure layer and the second conveyor structure layer.

US Pat. No. 10,427,878

PATCH MATERIAL FOR REPAIRING A DAMAGED PORTION OF A PRESSING BELT

1. A patch material for repairing a damaged portion of a pressing belt used on an agricultural round baler, the patch material comprising:an operative outer polymeric layer having a first thickness, and an operative outer surface;
a mounting layer disposed parallel to the operative outer polymeric layer and configured for placement against the pressing belt, the mounting layer having a second thickness being less than the first thickness;
at least one fabric layer disposed between the operative outer polymeric layer and the mounting layer;
a plurality of delineators disposed on the operative outer surface of the operative outer polymeric layer, wherein the plurality of delineators are arranged to define a pattern having a plurality of predefined shapes;
a plurality of connecting openings extending through the operative outer polymeric layer, the at least one fabric layer, and the mounting layer;
wherein, at least one of the plurality of the predefined shapes is arranged to bound a respective one of the plurality of connecting openings.