US Pat. No. 10,792,428

MEDICAMENT DELIVERY DEVICE HAVING GAS PROPELLANT

Consort Medical PLC, Hem...

1. A medicament delivery device comprising: a syringe having a barrel with an open end, and a stopper axially moveable and received in the barrel separating a first chamber axially forward the stopper from a second chamber axially rearward the stopper; and an expandable drive housing arranged to receive a propellant from a propellant source for providing a vapour pressure, the expandable drive housing having a narrow channel in direct fluid communication with the second chamber; wherein the expandable drive housing is expandable upon receiving the propellant from the propellant source and, upon expansion, causes forward axial movement of the syringe; and wherein the medicament delivery device is configured such that as the propellant is introduced into the expandable drive housing the propellant begins to pass directly through the narrow channel into the second chamber and causes forward axial movement of the stopper in the barrel to expel medicament contained in the first chamber through the open end, wherein the forward axial movement of the stopper in the barrel commences after the forward axial movement of the syringe.

US Pat. No. 10,792,427

HIGH FORCE INJECTION DEVICES

Allergan, Inc., Irvine, ...

1. A compressed gas assisted syringe comprising:a syringe body comprising a material cavity, a compression chamber, and a pressure bleed orifice;
a plunger head disposed proximal to the syringe body and configured to receive an applied force;
a plunger stem extending distally from the plunger head into the syringe body, the plunger stem comprising a cartridge chamber configured to house a compressed gas cartridge; and
a piercing element disposed in the syringe body and configured to engage the compressed gas cartridge in response to the applied force,
wherein the piercing element is configured to release a compressed gas into the compression chamber to push on the plunger head to provide extrusion assistance, the pressure bleed orifice is configured to allow the released compressed gas to bleed from the compression chamber, and an opening percentage of the pressure bleed orifice is adjustable to provide an inversely proportional amount of the extrusion assistance.

US Pat. No. 10,792,426

AUTOINJECTOR SYSTEM

AVANT MEDICAL CORP., Tho...

1. A system for injecting a medicament into a patient, the system comprising:an injector; and
a medicament cassette;
the medicament cassette comprising:
a housing comprising one or more walls having a lateral opening extending therethrough in a direction perpendicular to a longitudinal axis of the housing;
a sleeve movable in the housing between first and second positions; and
a syringe comprising a chamber for containing a medicament and an injection needle extending from the chamber, the syringe fixed with the sleeve to move along therewith, with the chamber at least partially disposed in the sleeve, the injection needle having a skin penetrating end opposite the syringe chamber, the skin penetrating end of the injection needle being disposed within the housing when the sleeve is in the first position and the skin penetrating end of the injection needle extending out from the housing when the sleeve is in the second position;
the injector comprising:
a surface for removably mounting the cassette thereon;
a motor driven link having a first end engageable with a portion of the sleeve when the cassette is mounted on the surface, wherein the portion of the sleeve extends laterally outwardly therefrom and at last partially through the opening of the housing, the link configured to engage the portion of the sleeve to move the sleeve from the first position to the second position.

US Pat. No. 10,792,425

TREATMENT SYSTEM WITH AUTOMATED CANNULA AND SENSOR INSERTER, FLUID DELIVERY DEVICE, AND DRIVE MECHANISM FOR USE THEREWITH

1. A treatment system configured to treat a condition using a first fluid, the treatment system comprising:a first reservoir configured to store a first fluid;
a first plunger disposed within the first reservoir;
a cannula insertion mechanism configured to insert a cannula into a user, the cannula in fluid communication with the first reservoir;
a first flexible member;
a first rotatable shaft member configured to pull the first plunger disposed within the first reservoir and coupled to the first rotatable shaft member by the first flexible member; and
a drive mechanism having a first expandable member configured to move from a first position to a second position to rotate the first rotatable shaft member to deliver the first fluid to the user through the cannula,
wherein the first rotatable shaft is configured to shorten a length of the first flexible member to deliver the first fluid to the user.

US Pat. No. 10,792,424

LIQUID MEDICINE ADMINISTRATION DEVICE

TERUMO KABUSHIKI KAISHA, ...

1. A liquid medicine administration device for administration of a liquid medicine in a state in which the device is attached to a body of a user, the device comprising:a liquid delivery unit configured to deliver the liquid medicine into a living body of the user and to perform a liquid delivery operation in (i) a bolus mode in which the delivery amount of insulin per unit time is temporarily increased, and (ii) a basal mode in which insulin as the liquid medicine is continuously delivered in a fixed amount;
a control unit configured to control the liquid delivery operation of the liquid delivery unit;
an activity detection unit configured to detect an activity of the user based on a motion of the body of the user;
a storage unit configured to store data indicating an amount of the liquid medicine that has already been delivered by the liquid delivery unit into the living body and configured to store at least one residual amount estimation equation; and
a calculation unit configured to, in the bolus mode:
calculate a residual amount of the liquid medicine in the living body on the basis of (i) the data indicating the amount of the liquid medicine that has already been delivered by the liquid delivery unit into the living body in a previous bolus, (ii) the activity of the user detected by the activity detection unit after the previous bolus, and (iii) an elapsed time from the previous bolus, using the at least one residual amount estimation equation, and
calculate a scheduled delivery amount of the liquid medicine to be administered into the living body on the basis of the residual amount of the liquid medicine,
wherein the control unit is configured to control the liquid delivery operation of the liquid delivery unit such that the scheduled delivery amount of the liquid medicine is delivered to the living body.

US Pat. No. 10,792,423

METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR PHYSIOLOGY PARAMETER-INVARIANT MEAL DETECTION

The Trustees of the Unive...

1. A method for physiology parameter-invariant meal detection, the method comprising:receiving insulin intake information and glucose level information for a user, wherein the glucose level information is obtained from a number of historical glucose level readings taken before or after one or more meal events involving the user and the insulin intake information is obtained from a number of historical insulin intake events including one or more insulin bolus events occurring at or during the one or more meal events;
detecting a meal event using a physiology parameter-invariant meal detection algorithm, wherein the physiology parameter-invariant meal detection algorithm uses a null space projection to detect the meal event regardless of the user's insulin sensitivity and insulin diffusion rate, wherein the physiology parameter-invariant meal detection algorithm uses a sliding window of time corresponding to the historical glucose level readings and historical insulin intake events, wherein the physiological parameter-invariant meal detection algorithm includes generating an F-statistic for indicating a ratio of measurement energy aligned with meal effects in a sub-window of the sliding window of time to other measurement energy in the sub-window, wherein the F-statistic indicates a test decision for the sub-window, wherein the physiology parameter-invariant meal detection algorithm analyzes consecutive sub-windows of the sliding window to identify sequential test decisions, wherein the physiology parameter-invariant meal detection algorithm filters the sequential test decisions by generating a cumulative decision score indicative of the likelihood that the meal event occurred, wherein the physiology parameter-invariant meal detection algorithm determines that the meal event occurred when the cumulative decision score exceeds a threshold value for a predetermined amount of time; and
after detecting the meal event, performing at least one control action associated with insulin management, wherein the at least one control action includes triggering a release of insulin or preventing the release of insulin by an insulin pump.

US Pat. No. 10,792,422

DYNAMICALLY CONTROLLED TREATMENT PROTOCOLS FOR AUTONOMOUS TREATMENT SYSTEMS

White Bear Medical LLC, ...

1. A therapeutic delivery apparatus comprising:a therapy module operably coupled to a processor, the therapy module comprising a compression garment, wherein the therapy module is adapted to deliver a predetermined compression therapy to a patient according to a treatment parameter operating point defined by a set of parameters associated with the delivery of the therapy in response to receiving a command signal transmitted by the processor;
a communication interface configured for communicating information about the patient to a remote or local server, the communicated information including information about a result of the therapy applied to the patient by the therapy module;
the processor operably coupled to control the therapy module according to the treatment parameter operating point, and operably coupled to the communication interface to generate a message that includes the result of the therapy applied to the patient by the therapy module; and,
a memory device operably coupled to the processor and containing instructions, that when executed by the processor, cause the processor to perform operations to dynamically adjust the treatment parameter operating point, the operations comprising:
receive a current treatment parameter operating point that lies within a first predetermined operating region defined by a first set of operating points for which automatic incremental adjustment of a parameter in the current operation is permitted;
receive a request to alter the current treatment parameter operating point to a second treatment parameter operating point that lies outside of the first predetermined operating region and in a second predetermined operating region defined by a second set of operating points for which authorization is required, wherein the second predetermined operating region lies outside of the first predetermined operating region in a space of operating points;
request authorization to alter the treatment parameter operating point from the first predetermined operating region to the second predetermined operating region;
if the requested authorization is received, then generate a second command signal to the therapy module for delivering therapy to the patient according to the second treatment operating point; and,
if the requested authorization is denied, then generate a first command signal to the therapy module for delivering therapy to the patient according to the first treatment operating point,
wherein in response to the first command signal being received at the therapy module, the therapy module delivers a first predetermined compression therapy to the patient, the first predetermined compression therapy being associated with the first treatment operating point,
wherein in response to the second command signal being received at the therapy module, the therapy module delivers a second predetermined compression therapy to the patient, the second predetermined compression therapy being associated with the second treatment operating point.

US Pat. No. 10,792,421

AUTOMATIC INSULIN DELIVERY SYSTEM WITH MINIMIZED INPUT VARIABLE LAG

Iowa State University Res...

1. A method comprising steps of:providing an insulin delivery system;
providing a model to predict and determine an amount of insulin to administer, the model stored on a machine readable non-transitory media associated with a computing device;
providing predictive inputs and measured inputs to the model;
parameterizing the model using the inputs to provide an output;
computing the output from the model by executing instructions using a processor of the computing device; and
administering insulin using the insulin delivery system based on the output, wherein the administration of insulin proactively nullifies the effect of any disturbances on blood glucose concentration,
wherein the model includes the feedforward predictive control law ofx2,t=G2?1(V2,t).

US Pat. No. 10,792,420

OCCLUSION DETECTION FOR INFUSION PUMPS

CAREFUSION 383, INC., Sa...

1. A system for detection of a fluid condition in a flexible tubing, the system comprising:a flexible tube;
a sensor coupled to a wall of the tube via a restraining element and configured to obtain a value of a tubing force when the tube is deformed by the restraining element;
a memory storing instructions; and
a processor configured to execute the instructions to determine parameters for fitting a force-time curve, the curve comprising varying values of the tubing force over time, to determine a fluid pressure value for a fluid in the tube based on the parameters for fitting the curve, and to activate an alarm responsive to the fluid pressure value and to the parameters for fitting the curve when an abnormal condition is identified in the fluid, wherein the parameters for fitting the force-time curve comprise at least one time-decaying parameter associated with the tubing force,
wherein, to determine the fluid pressure value, the processor is configured to determine a force on the wall of the tube using the at least one time-decaying parameter, and to adjust the at least one time-decaying parameter based on a material, a dimension, and a use history of the tube.

US Pat. No. 10,792,419

INFUSION SET AND INSERTER ASSEMBLY

DEKA Products Limited Par...

1. An infusion device comprising:a base portion comprising at least one tube routing organizer cutout configured to retain a portion of a length of tubing;
a cannula;
a septum retainer comprising a retainer cutout formed as a depression in central portion of a skin-facing face of the septum retainer; and
a connector comprising a connector needle, the connector configured to be removably attached to the base portion, the length of tubing having a downstream terminal end which is attached to the connector and in fluid communication with the connector needle,
wherein the cannula is located within the retainer cutout.

US Pat. No. 10,792,418

SELF-ORIENTING PRESSURE JACKET AND PRESSURE JACKET-TO-INJECTOR INTERFACE

BAYER HEALTHCARE LLC, Wh...

1. A pressure jacket comprising:a barrel having a proximal end, a distal end, and a sidewall extending substantially circumferentially between the proximal end and the distal end along a longitudinal axis, the barrel having an inner surface that defines an interior volume configured for receiving a syringe therein, the inner surface configured to engage an outer surface of a syringe barrel to limit a radial expansion of the syringe barrel during an injection procedure; and
at least one pressure jacket retaining member having at least one lug protruding radially outwardly relative to an outer surface of the sidewall, the at least one lug tapering axially along the outer surface of the sidewall in a direction from the distal end toward the proximal end_to a proximal pointed end,
wherein the at least one lug is configured to engage with a locking mechanism on a fluid injector to releasably lock the pressure jacket with the fluid injector, and
wherein a taper of the at least one lug is configured to rotationally guide the pressure jacket into self-orienting alignment with a pressure jacket port of the locking mechanism via contact with a guiding surface of the locking mechanism and axially eject the pressure jacket from the pressure jacket port of the locking mechanism upon rotation of the pressure jacket via contact between the taper of the at least one lug and with at least one ejection surface of the locking mechanism.

US Pat. No. 10,792,417

REMOVABLE TRANSMISSION FOR USE WITH A POWERED SURGICAL TOOL, THE TRANSMISSION SHAPED TO EXTEND ABOVE THE TOOL, AND SYSTEM

Stryker Corporation, Kal...

1. A transmission for use with a powered surgical tool, the powered surgical tool having a body and a rotating drive spindle that extends from the body and is configured to releasably receive and drive an implement, said transmission comprising:a housing;
an input shaft adapted to releasably engage the drive spindle of the powered surgical tool,
wherein said housing has a feature for releasably attaching said housing to the body of the powered surgical tool so that when said housing is attached to the powered surgical tool, said input shaft is releasably engaged with the drive spindle so as to be able convert an output moment of the drive spindle; and
said housing being configured to at least partially extend over a portion of the powered surgical tool when said housing is attached to the body of the powered surgical tool.

US Pat. No. 10,792,416

SYSTEM AND METHOD FOR COLLECTING PLASMA

HAEMONETICS CORPORATION, ...

1. A method for collecting plasma comprising:(a) determining a weight and height of a donor;
(b) determining a hematocrit of the donor;
(c) calculating a donor plasma volume based, at least in part, on the weight and height of the donor and the hematocrit of the donor;
(d) calculating a target plasma collection volume based, at least in part, on the calculated donor plasma volume and a target percentage of plasma;
(e) withdrawing whole blood from the donor through the venous-access device and a first line, the first line connected to a blood component separation device;
(f) introducing anticoagulant into the withdrawn whole blood through an anticoagulant line;
(g) separating the withdrawn whole blood into a plasma component and at least a second blood component using the blood component separation device;
(h) collecting the plasma component from the blood component separation device and into a plasma collection container;
(i) calculating a volume of anticoagulant in the collected plasma component as the plasma component is being collected in the plasma collection container;
(j) calculating a volume of pure plasma collected within the plasma collection container based, at least in part, on the calculated volume of anticoagulant in the collected plasma component; and
(k) continuing steps (e) through (j) until the calculated volume of pure plasma collected within the plasma collection container equals the target plasma collection volume.

US Pat. No. 10,792,415

FAILSAFE SYSTEM AND METHOD FOR A MEDICAL FLUID PROCEDURE

Fenwal, Inc., Lake Zuric...

1. A medical fluid processing apparatus, comprising:a sealer configured to receive at least a portion of a tubing segment of a fluid flow circuit, the sealer including an authentication system comprising one or more transponders included within the sealer and configured to authenticate the fluid flow circuit; and
a controller configured to receive input from the authentication system and, upon receiving input from the authentication system indicative of a failure to authenticate the fluid flow circuit, activate the sealer to seal said at least a portion of the tubing segment received by the sealer, so as to render the fluid flow circuit unusable.

US Pat. No. 10,792,414

UNIVERSAL PORTABLE MACHINE FOR ONLINE HEMODIAFILTRATION USING REGENERATED DIALYSATE

Fresenius Medical Care Ho...

1. A manifold comprising:a manifold body comprising
a first transom comprising a first edge, and second and third edges substantially parallel to the first edge,
a trunk substantially perpendicular to and adjacent the first transom,
a second transom comprising a fourth edge, and fifth and sixth edges substantially parallel to the first, second, and third edges, the second transom being substantially perpendicular to and adjacent the trunk and substantially parallel to the first transom;
a first external port and a second external port located on the fourth edge,
a first intra-manifold port located on the second edge,
a second intra-manifold port located on the second edge,
a third intra-manifold port located on the fifth edge, and
a fourth intra-manifold port located on the fifth edge;
a first conduit in the second transom and in fluid communication with the second external port and the third intra-manifold port;
a second conduit in the manifold body and in fluid communication with both the second intra-manifold port and the first external port;
a first pump tube connected to and in fluid communication with the first and third intra-manifold ports;
a second pump tube connected to and in fluid communication with the second and fourth intra-manifold ports;
a first external tube connected to and in fluid communication with the first external port and comprising an external main segment, a first external branch segment, and a second external branch segment; and
an external blood tube in fluid communication with and extending from the second external port,
wherein the external main segment is connected to the first external port, the first external branch segment is connected to the external main segment and is configured to be connected to a dialyzer, the second external branch is connected to the external main segment and is in fluid communication with the external blood tube upstream of the first pump tube, and the entire manifold comprises disposable components.

US Pat. No. 10,792,413

IMPLANTABLE AND REMOVABLE CUSTOMIZABLE BODY CONDUIT

Merit Medical Systems, In...

1. A system for treating a stenosis, the system comprising:an elongate body comprising a proximal portion, a distal portion, and a lumen extending therebetween along a longitudinal axis, wherein the distal portion configured to be inserted through a stenosis such that the proximal portion is positioned proximal of the stenosis and the distal portion is positioned distal of the stenosis;
an inner surface of the elongate body defining the lumen and an outer surface of the elongate body surrounding the inner surface;
a cuff coupled to an end portion of the elongate body and configured to be separated from the elongate body,
wherein an outer surface of the cuff is configured to adhere to in vivo matter to stabilize the elongate body; and
a separation zone disposed between the cuff and the end portion of the elongate body, the separation zone comprising a separable bond between the elongate body and the cuff, wherein the cuff separates from the elongate body when a predetermined amount of force is applied to the separation zone without ripping the elongate body,
where the predetermined force is oriented in a longitudinal direction of the elongate body.

US Pat. No. 10,792,412

METHOD FOR VENTING A DIALYZER

FRESENIUS MEDICAL CARE DE...

1. A method for venting a dialyzer which has a dialyzate chamber at a dialyzate chamber side, a blood chamber and a semipermeable dialyzer membrane separating these two chambers, the method comprising generating an overpressure in the dialyzate chamber with respect to the blood chamber for removing air inclusions lying at a surface of the membrane at the dialyzate chamber side after a filling of the dialyzate chamber and before a filling of the blood chamber, said blood chamber being vented toward the environment during the generating of the overpressure.

US Pat. No. 10,792,410

BIOARTIFICIAL LIVER

Mayo Foundation for Medic...

1. A bioartificial liver device comprising a blood separation cartridge in fluid communication with a reservoir chamber, wherein said reservoir chamber comprises hepatocyte spheroids, a means for mixing, a mixing chamber, and a settling volume chamber, wherein said mixing chamber is located below said settling volume chamber and separated from said settling volume chamber by a funnel, wherein said mixing chamber is in fluid communication with said settling volume chamber via an open spout defined in said funnel, wherein said means for mixing is arranged in the mixing chamber and below said open spout, wherein said open spout is located from a bottom, inner surface of said mixing chamber at a distance configured to minimize net loss of said hepatocytes spheroids out of said mixing chamber to said settling volume chamber.

US Pat. No. 10,792,409

PERITONEAL DIALYSIS TREATMENT SYSTEM AND METHOD OF OPERATION

Debiotech S.A., Lausanne...

1. A method for performing peritoneal dialysis treatment on a patient by a dialysis system, the dialysis system including a dialysate circuit configured to be in fluidic connection with a peritoneal cavity of the patient, a pumping device configured to cause dialysate to flow through the dialysate circuit to or from the peritoneal cavity of the patient, a sensor configured to measure a pressure of the dialysate, and a processor operatively coupled to the pumping device and the sensor, the method comprising the steps of:measuring a pressure representing an intraperitoneal pressure of the peritoneal cavity during a stasis phase with the sensor, the peritoneal cavity of the patient being in fluidic connection with the dialysate circuit during the entire stasis phase; and
initiating a withdrawal of a dialysate volume fraction from the peritoneal cavity during a time window of the stasis phase with the processor, according to a result of the measuring, the time window for initiating the withdrawal being shorter in duration than a duration of the stasis phase.

US Pat. No. 10,792,408

MEDICAL FLUID THERAPY MACHINE INCLUDING READILY ACCESSIBLE PNEUMATIC MANIFOLD AND VALVES THEREFORE

Baxter International Inc....

1. A connection apparatus for sealing to a pathway of a mounting structure, the connection apparatus comprising:a body; and
a port including a threaded portion extending from the body and a non-threaded portion extending from the threaded portion, the non-threaded portion carrying a gasket, the gasket positioned along the non-threaded portion such that the mounting structure to which the connection apparatus is mounted contacts the gasket prior to the threaded portion engaging a mating threaded portion of the mounting structure, the port providing fluid communication between the body and the pathway of the mounting structure, and wherein the gasket is configured to create a seal between the pathway and both the threaded portion and mating threaded portion after engagement.

US Pat. No. 10,792,407

PERCUTANEOUS DRIVELINE ANCHOR DEVICES AND METHODS OF USE

1. A skin anchor for securing a percutaneous driveline to a portion of skin, the driveline connecting an external controller or power source to an implantable blood pump, the skin anchor comprising:a driveline capture portion configured to receive the driveline and fix a position of the driveline with respect to the driveline capture portion, wherein the driveline capture portion comprises:
a driveline receiver configured to receive the driveline; and
a driveline anchor configured to engage the driveline to fix the position of the driveline with respect to the driveline receiver; and
a force distribution portion extending from the driveline and configured to engage a portion of the skin and fix a position of the force distribution portion with respect to the portion of the skin so as to secure the force distribution portion directly to the skin.

US Pat. No. 10,792,406

CATHETER PUMP ARRANGEMENT AND FLEXIBLE SHAFT ARRANGEMENT HAVING A CORE

ECP ENTWICKLUNGSGESELLSCH...

1. A flexible drive shaft, comprising:a shaft having a proximal end at a drive device and a distal end at an output side, the shaft formed as a hollow lumen; and
at least one core positioned within the hollow lumen, wherein the core is configured to rotate with the shaft, wherein the at least one core is coupled to an inside of the hollow lumen.

US Pat. No. 10,792,405

VENTRICULAR ASSIST SYSTEM AND BLOOD PUMP CONTROLLER

SUN MEDICAL TECHNOLOGY RE...

1. A ventricular assist system comprising:a blood pump having: a fixed side slide member having an annular first slide surface; a rotary side slide member having an annular second slide surface; a blood pump chamber positioned on an outer peripheral side of the fixed side slide member and the rotary side slide member, an impeller housed in the blood pump chamber and being integrally rotatable with the rotary side slide member; a motor capable of imparting rotary energy to the impeller; and a cool sealing liquid flow chamber which is positioned on an inner peripheral side of the fixed side slide member and the rotary side slide member and through which a cool sealing liquid supplied from an outside flows, the blood pump being used in a state where the first slide surface and the second slide surface are brought into contact with each other, and the cool sealing liquid is supplied to a gap formed between the first slide surface and the second slide surface from the cool sealing liquid flow chamber;
a blood pump controller for driving the blood pump and for supplying the cool sealing liquid to the blood pump;
an electric cable for transmitting a drive signal from the blood pump controller to the blood pump;
an up tube through which the cool sealing liquid is made to flow from the blood pump controller to the blood pump; and
a down tube through which the cool sealing liquid is made to flow from the blood pump to the blood pump controller, wherein
the blood pump controller includes:
a blood pump drive circuit electrically connected to the electric cable and provided for driving the motor of the blood pump;
a battery electrically connected to the blood pump drive circuit for supplying a power source to the blood pump drive circuit;
a first cool sealing liquid reservoir for storing the cool sealing liquid;
a cool sealing liquid pump for sucking the cool sealing liquid supplied from the first cool sealing liquid reservoir and discharging the sucked cool sealing liquid;
a first pipe joint formed of a first pipe joint upstream side and a first pipe joint downstream side which are detachably connected to each other and being capable of relaying the cool sealing liquid supplied from the cool sealing liquid pump;
a second pipe joint formed of a second pipe joint upstream side and a second pipe joint downstream side which are detachably connected to each other where the second pipe joint downstream side is connected to the up tube so as to enable the second pipe joint to relay the cool sealing liquid supplied from the first pipe joint to the up tube;
a third pipe joint formed of a third pipe joint upstream side and a third pipe joint downstream side which are detachably connected to each other where the third pipe joint upstream side is connected to the down tube so as to enable the third pipe joint to relay the cool sealing liquid supplied from the down tube to an inside of the blood pump controller; and
a fourth pipe joint formed of a fourth pipe joint upstream side and a fourth pipe joint downstream side which are detachably connected to each other and being capable of relaying the cool sealing liquid supplied from the third pipe joint downstream side to the first cool sealing liquid reservoir, and
the blood pump controller includes:
a first sub controller (home station) having the first cool sealing liquid reservoir, the cool sealing liquid pump, the first pipe joint upstream side, and the fourth pipe joint downstream side; and
a second sub controller (a portable side controller) having the blood pump drive circuit, the battery, the first pipe joint downstream side, the second pipe joint upstream side, the third pipe joint downstream side, and the fourth pipe joint upstream side, and
the first sub controller and the second sub controller are separable from each other and are joinable to each other by detachably connecting the first pipe joint and the fourth pipe joint.

US Pat. No. 10,792,404

METHODS AND DEVICES FOR APPLYING CLOSED INCISION NEGATIVE PRESSURE WOUND THERAPY

KCI Licensing, Inc., San...

1. A system to treat an area of tissue trauma, the system comprising:a sealant structure comprising an adhesive configured to form a sealed space around the area of tissue trauma;
a limiting element configured to limit an amount of contraction of the sealant structure;
an elastic element configured to exert a force on tissue adjacent to the area of tissue trauma to relieve tension on the area of tissue trauma; and
a carrier structure comprising a set of ribs configured to provide rigidity to the sealant structure and to maintain the sealant structure in a stretched state when the carrier structure is removably coupled to the sealant structure.

US Pat. No. 10,792,403

SUCTION SWAB FOR SURGICAL USE

ARTHREX, INC., Naples, F...

1. A surgical method, comprising:debriding an osteochondral defect of a bone to a stable border having perpendicular margins,
wherein the debriding includes using a curette and an elevator to form the stable border;
creating a bleeding bone bed near the osteochondral defect of the bone;
drying the osteochondral defect with a suction swab, wherein drying the osteochondral defect includes:
suctioning moisture through a swab tip of the suction swab, then through a plurality of fenestrations formed through a distal end of a tube of the suction swab, and then through a passage in the tube; and
communicating a gas through the passage in the tube of the suction swab, then through the plurality of fenestrations, and then through the swab tip,
wherein the gas is nitrogen;
wherein the suctioning and the communicating occur at different times during the drying,
wherein the passage of the tube is a singular common passage of the tube;
inserting a cannula through an arthroscopic portal that resides over the osteochondral defect;
distracting the arthroscopic portal with the cannula to improve visualization of the osteochondral defect; and
delivering a micronized cartilage matrix scaffold over the osteochondral defect with a delivery needle.

US Pat. No. 10,792,402

SYSTEM AND METHOD FOR APPLYING REDUCED PRESSURE AT A TISSUE SITE

KCI Licensing, Inc., San...

1. An apparatus for applying reduced pressure to a tissue site, the apparatus comprising:a first casing portion;
a second casing portion;
a hydrophobic filter disposed in a housing having at least one gap;
a first chamber disposed in the first casing portion;
a second chamber disposed in the second casing portion and fluidly coupled to the first chamber through the hydrophobic filter; and
a one-way valve having a flap configured to cover the at least one gap;
wherein the first casing portion is configured to slide relative to the second casing portion to compress the first chamber.

US Pat. No. 10,792,394

METHODS FOR LOCALIZED MODIFICATION OF TISSUE PRODUCTS

LIFECELL CORPORATION, Ma...

1. A method for modifying a tissue product, comprising:selecting a collagen-containing tissue product;
providing a hydrophilic material having at least one strut having a shape corresponding to a desired pattern;
applying to the hydrophilic material a fluid containing at least one agent capable of passing through the hydrophilic material to a top side of the hydrophilic material and modifying the collagen-containing tissue product; and
contacting the collagen-containing tissue product with the at least one strut at the top side of the hydrophilic material to bring select regions of the collagen-containing tissue product into contact with the top side of the hydrophilic material and the fluid.

US Pat. No. 10,792,393

REINFORCED TISSUE GRAFT

THE CLEVELAND CLINIC FOUN...

1. A biocompatible tissue graft comprising:an extracellular matrix (ECM) derived from collagen; and
a plurality of fibers stitched into the ECM in a concentric reinforcement pattern, each of the fibers comprising the plurality of fibers having opposing terminal ends;
wherein the plurality of fibers comprises a plurality of interconnected stitches;
wherein the opposing terminal ends of each of the fibers are stitched together to form a continuous stitching construction;
wherein the plurality of fibers mitigates tearing and/or improves fixation retention of the graft.

US Pat. No. 10,792,392

IONIC POLYMER COMPOSITIONS

Hyalex Orthopedics, Inc.,...

1. A packaged article comprising an orthopedic implant and a divalent-cation-containing solution contained within a sterile package, wherein the orthopedic implant comprises a crosslinked ionic polymer that comprises sulfonic-acid-derivatized groups, wherein the sulfonic-acid-derivatized groups are present at a surface of the crosslinked ionic polymer and extend from the surface into a bulk of the crosslinked ionic polymer by a distance of at least 500 microns, said crosslinked ionic polymer has a thickness of up to 10 mm, and the divalent-cation-containing solution comprises 0.5 to 5.0 mM calcium ions and 0.2 to 1.5 mM magnesium ions.

US Pat. No. 10,792,391

BIODEGRADABLE MAGNESIUM ALLOY NERVE CONDUIT FOR NERVE DEFECT REPAIR AND ITS PREPARATION METHOD

SHANGHAI JIAO TONG UNIVER...

1. A biodegradable magnesium alloy nerve conduit for nerve defect repair, wherein:the biodegradable magnesium alloy nerve conduit has a circular cross-sectional area, a length in a range of 5-50 mm, and a thickness in a range of 0.1-0.2 mm;
the biodegradable magnesium alloy nerve conduit has multiple lines of through holes in a tube wall thereof, an aperture of each of the multiple lines of through holes is in a range of 0.03-0.3 mm, and a porosity of the nerve conduit is in a range of 2-20%;
each line of through holes are arranged along an axial direction of the nerve conduit at equal distances, and adjacent lines of through holes are arranged in a staggered way.

US Pat. No. 10,792,389

ENZYME DEGRADABLE SYSTEM FOR UNDERGARMENTS AND FEMININE HYGIENE ARTICLES

1. An enzyme-degradable system for an undergarment and a feminine hygiene article, the system comprising:an absorbent core, the core including at least one of the following: a cellulose, a wood pulp, a thermoplastic aliphatic polyester, and a superabsorbent polymer;
an inner sheet comprising a plant based cellulosic nonwoven material;
an outer sheet comprising the plant based cellulosic nonwoven material; and
a cellulase enzyme being integrated into the absorbent core, or the sheets, or both, the cellulase enzyme helping to at least partially decompose at least one of: the absorbent core, the inner sheet, and the outer sheet upon contact with a bodily fluid,
wherein the cellulase enzyme comprises Aspergillus niger cellulase having an activity of 10,000-500,000 units per gram in a solid form or 10,000-500,000 units per gram in a liquid form.

US Pat. No. 10,792,388

DEVELOPED SAFETY PORTABLE INCENSE HEATER

1. A developed safety portable incense heater comprising:a hollow housing body having a horizontal housing attached to a vertical housing;
wherein the vertical housing comprising a rear and front vertical housing having a bottom curved end to be mounted with the rear vertical housing and a right and left vertical grill housing attached to both the front and the rear vertical housing;
wherein the horizontal housing comprises a hinge arm connected from the front end to an outlet cap housing forming a one part and from the rear end to the top surface of the rear vertical housing through a hinge spring mounted inside the hinge arm end to hold the hinge arm while the users opens the hinge arm;
a fan mounted on the top inner side of the rear vertical housing in the same horizontal axis with an inlet grill attached to the rear vertical housing allowing fresh air to be sucked and derived through an airduct guide mounted on the other side of the fan towards and around a heater housing generating a suction force inside an incense heating chamber mounted inside the heating housing while the air will carry the fragrance smoke from inside the incense heating chamber to the front outlet grill spreading the incense fragrance smoke with high speed air outside to users; and
silicon rubber rings placed between the fan and the airduct preventing vibration inside the horizontal housing.

US Pat. No. 10,792,387

DISINFECTANT DISPENSER FOR STORING AND DELIVERING AN AGENT FOR DISINFECTING SURFACES AND/OR SKIN, DISINFECTANT AND METHOD FOR PUBLICALLY SIGNALLING A DISINFECTED STATE OF PERSONS

Heyfair GmbH, Jena (DE)

5. A method for public signaling of a disinfection state of persons, the method comprising the steps:applying a disinfecting mix including a disinfecting component and a marking component to a skin area to be disinfected at a disinfection station (18) and/or from a portable disinfectant dispenser;
coloring the skin area to be disinfected by the marking component during the disinfection process;
persisting visually the coloration on the disinfected skin area, wherein the disinfection state of the skin area is signaled in a perceivable and detectable manner; and
subsiding of the persistence of the coloration on or before subsiding sterility of the skin area, wherein a discoloration or change in color caused thereby is also signaled in a perceivable and detectable manner;
characterized in that
the visual persistence of the coloration on the disinfected skin area commences on or after a sterility of the skin area is caused by the disinfecting component;
characterized in that
the disinfecting component has a germicide effect, and
the visible persistence of the coloration on the skin area is caused by the germicide effect of the disinfecting component, wherein biological decomposition products thus generated cause a visible color reaction in the marking component.

US Pat. No. 10,792,386

APPARATUS AND METHOD TO REPEATEDLY FILL AND PURGE CHANNELS OF ENDOSCOPE

ASP GLOBAL MANUFACTURING ...

1. A method for reprocessing an internal channel of a medical device, the method comprising:(a) activating one or more pumps to deliver a detergent to the internal channel for a first predetermined duration;
(b) activating the one or more pumps to deliver water to the internal channel to rinse out the detergent for a second predetermined duration;
(c) activating the one or more pumps to deliver pressurized air to the internal channel to purge out any remaining water or detergent contained within the internal channel for a third predetermined duration;
(d) activating the one or more pumps to deliver a predetermined volume of disinfectant to the internal channel;
(e) reactivating the one or more pumps to deliver pressurized air to the internal channel to purge out the disinfectant from the internal channel into a chamber;
(f) reactivating the one or more pumps to deliver additional disinfectant to the internal channel; and
(g) reactivating the one or more pumps to deliver pressurized air to the internal channel to purge out the additional disinfectant from the internal channel into the chamber.

US Pat. No. 10,792,385

STERILIZING FLOOR ARRAY

1. A device comprising a plurality of tiles, wherein each tile of the plurality of tiles comprises:an ultraviolet light source comprising ultraviolet emitters in a plurality of ultraviolet wavelength bands;
a touch sensor;
a processor; and
a computer-readable medium storing instructions which, when executed by the processor, cause the processor to perform operations, the operations comprising:
detecting, via the touch sensor of a respective tile, a tactile state of the respective tile;
detecting a tactile state of at least one additional tile of the plurality of tiles;
determining, based upon the tactile state of the respective tile and the tactile state of the at least one additional tile, that the respective tile is on an interior of a pattern of contact between an object and a surface comprising the respective tile and the at least one additional tile; and
activating the ultraviolet light source in response to the determining that the respective tile is on the interior of the pattern of contact, wherein the activating comprises applying at least one ultraviolet wavelength band of the plurality of ultraviolet wavelength bands based on a type of the object.

US Pat. No. 10,792,383

METHOD OF DISINFECTING A MEDICAL DEVICE

3M Innovative Properties ...

1. A method of disinfecting a medical device, the method comprising:a) contacting a disinfectant with a process indicator and the medical device,
wherein the medical device is a lumened device comprising at least one internal conduit;
wherein a process indicator module comprises the process indicator;
wherein the disinfectant is circulated through the process indicator module and the at least one internal conduit; and
wherein the disinfectant comprises at least one aldehyde, wherein the process indicator comprises a layer comprising a crosslinked branched polyethylenimine is e-bean grafted on a substrate, wherein the crosslinked branched polyethylenimine is reactive with the disinfectant to form at least one adduct, wherein the crosslinked branched polyethylenimine and the medical device are in fluid communication through the disinfectant, wherein a predetermined disinfectant exposure criterion exists for contacting the disinfectant with the medical device, and wherein the crosslinked branched polyethylenimine comprises at least one of primary amino groups or secondary amino groups; and
b) spectrally observing the process indicator and obtaining at least one parameter therefrom that is predictive of the predetermined disinfectant exposure criterion; and
c) determining that the predetermined disinfectant exposure criterion has been achieved.

US Pat. No. 10,792,382

DISTRIBUTION MANIFOLD WITH INTEGRATED CHECK VALVE

KleanTouch LLC, Scottsda...

1. A distribution manifold comprising:a manifold wall formed of a tubing, wherein the manifold wall forms an interior chamber, wherein the manifold wall also forms a plurality of self-healing distribution holes that communicate the interior chamber of the manifold wall with an exterior surface of the manifold wall, wherein the manifold wall also forms an opening configured to receive a fluid, wherein the received fluid enters the interior chamber and gets dispensed onto the exterior surface of the manifold wall through the plurality of self-healing distribution holes; and
a check valve coupled to the opening of the manifold wall, wherein the check valve is operatively configured to receive the fluid from a fluid source, to communicate the received fluid to the interior chamber of the manifold wall, and to prevent fluid from returning from the interior chamber back to the source.

US Pat. No. 10,792,381

SYSTEM FOR DISINFECTING SURFACES USING ULTRAVIOLET LIGHT

1. A system for disinfecting surfaces in a room comprising:a base;
a shaft coupled to said base and having an axis of rotation;
a mounting element coupled to said shaft, said mounting element having an upper surface and a lower surface;
at least one ballast positioned on said mounting element, said at least one ballast adapted to be connected to a source of electrical power;
at least one Ultraviolet (UV) lamp positioned on the lower surface of said mounting element and coupled to said at least on ballast, said at least one UV lamp adapted to emit radiation in a frequency that is harmful to bacteria;
an electric motor positioned on said mounting element and adapted to rotate said UV lamp about the axis.

US Pat. No. 10,792,380

SYSTEM AND APPARATUS FOR SANITIZING A POINT OF CONTACT

1. An apparatus for sanitizing an object, the apparatus comprising:a housing comprising one or more sidewalls, the housing defining an interior configured to receive the object;
a posterior wall disposed at a posterior end of the housing, the posterior wall extending inwardly from the one or more sidewalls;
a dome disposed at an anterior end of the housing, the dome at least partially defining an anterior opening for access to the interior; and
one or more sources of germicidal light disposed under the dome.

US Pat. No. 10,792,379

MAGNETITE IN NANOPARTICULATE FORM

COLOROBBIA ITALIA S.P.A.,...

1. A stable suspension of nanoparticulate magnetite in an aqueous environment having a value of specific absorption rate (SAR), when measured at a magnetic field H0 of 21 KA/m and a frequency of 170 kHz, of 119 to 643 J/g*K and a specific hyperthermia at a concentration of 1% by weight of magnetite nanoparticles of 2.4-54.20° C.

US Pat. No. 10,792,377

COMPOUNDS AND METHOD FOR IMAGING CANCER

Vanderbilt University, N...

1. A compound comprising a structure according to formula I:
wherein R is selected from O?,

US Pat. No. 10,792,372

MAYTANSINOID DERIVATIVES WITH SELF-IMMOLATIVE PEPTIDE LINKERS AND CONJUGATES THEREOF

IMMUNOGEN, INC., Waltham...

22. A pharmaceutical composition comprising the conjugate of claim 1 and a pharmaceutically acceptable carrier.

US Pat. No. 10,792,369

SULFAMIDE LINKER, CONJUGATES THEREOF, AND METHODS OF PREPARATION

SYNAFFIX B.V., Oss (NL)

1. A bioconjugate, comprising a biomolecule B and a target molecule D, wherein the bioconjugate further comprises a group according to formula (1):
covalently linked to an alpha-end at one side of the formula (1) and an omega-end at the other side of the formula (1), the alpha-end comprising the biomolecule B and the omega-end comprising the target molecule D,
wherein:
the wavy lines indicate covalent linkages to the alpha-end and the omega-end,
the biomolecule B is a glycoprotein;
a is 0 or 1; and
R1 is selected from the group consisting of hydrogen, C1-C24 alkyl groups, C3-C24 cycloalkyl groups, C2-C24 (hetero)aryl groups, C3-C24 alkyl(hetero)aryl groups and C3-C24 (hetero)arylalkyl groups, the C1-C24 alkyl groups, C3-C24 cycloalkyl groups, C2-C24 (hetero)aryl groups, C3-C24 alkyl(hetero)aryl groups and C3-C24 (hetero)arylalkyl groups optionally substituted and optionally interrupted by one or more heteroatoms selected from O, S and NR3 wherein R3 is independently selected from the group consisting of hydrogen and C1-C4 alkyl groups, or R1 is a target molecule D, wherein the target molecule is optionally connected to N via a spacer moiety,
or a salt thereof.

US Pat. No. 10,792,368

BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP

BicycleRD Limited, Cambr...

1. A compound of formula (IV):
wherein:
Toxin is the cytotoxic agent DM1;
Bicycle represents a peptide ligand comprising:
a polypeptide of the amino acid sequence:
(B-Ala)-Sar10-AC(D-Ala)NE(1Nal)(D-Ala)CEDFYD(tBuGly)C (SEQ ID NO: 5); and
a molecular scaffold which is TBMB (1,3,5-tris(bromomethyl)benzene), which forms covalent bonds with the cysteine residues of the polypeptide yielding a tri-substituted 1,3,5-trismethylbenzene structure;
R3 represents methyl, and R1, R2 and R4 each represent hydrogen;
m represents 1; and
n represents 1,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,792,367

CONJUGATES COMPRISING AN GLP-1/GLUCAGON DUAL AGONIST, A LINKER AND HYALURONIC ACID

SANOFI, Paris (FR)


wherein X14 is Lys, wherein the —NH2 side chain group is functionalized by (S)-4-carboxy-4-octadecanoylamino-butyryl; and
R20 is OH or NH2;or a salt or solvate thereof.

US Pat. No. 10,792,366

METHODS TO REDUCE TOXICITIES AND TO IMPROVE BIOAVAILABILITIES OF NANODRUGS

Carnegie Mellon Universit...

1. A method of treating cancer in a subject in need thereof, comprising (i) administering to the subject a fat emulsion comprising 20% soybean oil, 1.2% egg yolk, and 2.25% glycerol; and (ii) administering a therapeutically effective amount of a nanotherapeutic agent to the subject, wherein the nanotherapeutic agent comprises a therapeutic agent and a nanocarrier, wherein the nanocarrier is selected from the group consisting of a protein-coated nanoparticle and a polymer-coated nanoparticle; wherein said fat emulsion is administered to the subject about 0.5 hours to about 2 hours before the nanotherapeutic agent is administered to the subject;wherein the cancer is selected from the group consisting of breast cancer, prostate cancer, esophageal cancer, liver cancer, colon cancer, testicular cancer, endometrial cancer, brain cancer, bladder cancer, cancer of the uterus, cancer of the ovary, cervical cancer, lung cancer, sarcoma, bone cancer, pancreatic cancer, renal cancer, stomach cancer, and cancer of the head and neck;
wherein the therapeutic agent is dichloro(1,2-diaminocyclohexane)platinum(II);
wherein toxic side effects to the liver, kidney, or spleen are reduced as compared with a method of administration of the nanotherapeutic agent without pre-administration of the fat emulsion, and
wherein either serum alanine aminotransferase (ALT) or serum creatinine levels are significantly reduced as compared with a method of administration of the nanotherapeutic agent without pre-administration of the fat emulsion.

US Pat. No. 10,792,365

PEPTIDE DERIVATIVE AND USE THEREOF

Toray Industries, Inc., ...

1. A peptide derivative represented by Formula (I) or a pharmaceutically acceptable salt thereof:
wherein X represents an oxygen atom or NR, Y represents NH2, N(Me)H, SH, OH, or phenyl in which any one of hydrogen atoms is replaced by NH2 or OH, and R represents a hydrogen atom or C1-C3 alkyl, provided that the derivative where X is NH, and Y is NH2, and the derivative where X is NH, and Y is N(Me)H are excluded.

US Pat. No. 10,792,362

COMPOSITIONS AND METHODS FOR EFFICIENT DELIVERY OF MOLECULES TO CELLS

LIFE TECHNOLOGIES CORPORA...

1. A lipid aggregate comprising a first cationic lipid (i) dihydroxyl-dimyristylspermine (DHDMS) or salt thereof or (ii) hydroxyl-dimyristylspermine (HDMS) or salt thereof, at least a second cationic lipid, a first neutral lipid and optionally a second neutral lipid, wherein said lipid aggregate is suitable for forming a cationic complex with a nucleic acid under aqueous conditions, wherein said first and second cationic lipids are different from each other, and wherein said DHDMS has the structure:and salts thereof,and said HDMS has the structure:
and salts thereof.

US Pat. No. 10,792,360

COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE USING CCR9 INHIBITOR AND ANTI-TNF-ALPHA BLOCKING ANTIBODIES

ChemoCentryx, Inc., Moun...

1. A method of treating or reducing the development of inflammatory bowel disease in a mammal, said method comprising administering a suitable amount of a CCR9 inhibitor with an anti-TNF? blocking antibody, wherein the CCR9 inhibitor is Compound 1

US Pat. No. 10,792,359

METHODS OF USING A VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT

Infectious Disease Resear...

1. A method of eliciting or enhancing a desired antigen-specific immune response in a subject, the method comprising administering to the subject a pharmaceutical composition that comprises (a) one or more antigens, or at least one nucleic acid sequence encoding a polypeptide antigen; (b) a glucopyranosyl lipid adjuvant (GLA) having the formula:
where: R1, R3, R5 and R6 are C11-C20 alkyl; and R2 and R4 are C12-C20 alkyl; or a pharmaceutically acceptable salt thereof; and (c) at least one of a surfactant, biodegradable oil, pharmaceutically acceptable carrier, excipient and diluent; thereby eliciting or enhancing a desired antigen-specific immune response.

US Pat. No. 10,792,354

FEED ADDITIVE COMPOSITION FOR IMMUNOPROTECTION OF FISH AGAINST INFECTIOUS VIRAL SPECIES

UNIVERSITY OF MARYLAND BA...

1. A fish feed additive comprising a dried powder form biomass of an organism or cell culture in which the nervous necrosis virus (NNV) virus-like particles (VLPs) have been expressed, wherein the NNV VLPs mediate an immunoprotective response in a target fish species susceptible to NNV.

US Pat. No. 10,792,347

METHODS FOR DIAGNOSING AND TREATING ALZHEIMER'S DISEASE

Alternative Extracts Inc....

1. A method of maintaining and/or restoring tight junction integrity in cerebral vessels and thereby ameliorating symptoms of Alzheimer's Disease in a subject having Alzheimer's Disease consisting of administering to the subject bevacizumab.

US Pat. No. 10,792,337

WOUND HEALING COMPOSITIONS

KCI Licensing, Inc., San...

19. A system for treating a tissue site, the system comprising:a negative-pressure source;
a container adapted to contain a composition, wherein the composition comprises:
one or more matrix metalloprotease (MMP) substrates, wherein the MMP substrates comprise gelatin or a hydrolysate thereof,
one or more preservatives comprising a chelating agent, wherein the chelating agent is ethylenediaminetetraacetic acid (EDTA), and
a pharmaceutically-acceptable carrier;
a dressing in fluid communication with the negative-pressure source and adapted to distribute negative pressure to the tissue site, wherein the dressing has a first portion adapted for contact with the tissue site, and a second portion in fluid communication with the container;
a pump adapted to deliver the composition to the dressing; and
a drape adapted to cover the dressing.

US Pat. No. 10,792,335

RAPID-ACTING INSULIN COMPOSITION COMPRISING A SUBSTITUTED CITRATE

ADOCIA, Lyons (FR)

1. A composition, in the form of an aqueous solution, comprising an insulin in hexameric form and at least one substituted citrate of formula I:
in which:
R1, R2, R3, identical or different, represent OH or AA,
at least one of the R1, R2, R3 is an AA radical,
AA is a radical resulting from a natural or synthetic aromatic amino acid comprising at least one phenyl group or indole group, substituted or not substituted, said AA radical having at least one free carboxylic acid group,
the carboxylic acid groups are in the form of a salt of an alkali metal selected from Na+ and K+, and
wherein the composition is free of EDTA.

US Pat. No. 10,792,328

NANOCOMPLEXES FOR DELIVERY OF SAPORIN

Trustees of Tufts College...

1. A nanocomplex comprising saporin and a lipid-like compound, wherein the nanocomplex has a particle size of 50 nm to 1000 nm; the saporin binds to the lipid-like compound via non-covalent interaction; and the lipid-like compound has a hydrophilic moiety, a hydrophobic moiety, and a linker joining the hydrophilic moiety and the hydrophobic moiety,wherein
the hydrophobic moiety is a heteroaliphatic radical comprising one or more —S—S— groups and 8 to 24 carbon atoms;
the hydrophilic moiety is optionally charged, and is an aliphatic or heteroaliphatic radical comprising one or more hydrophilic groups and 1-20 carbon atoms, each of the hydrophilic groups being amino, alkylamino, dialkylamino, trialkylamino, tetraalkylammonium, hydroxyamino, hydroxyl, carboxyl, carboxylate, carbamate, carbamide, carbonate, phosphate, phosphite, sulfate, sulfite, or thiosulfate; and
the linker is O, S, Si, C alkylene,

in which each of m, n, p, q, and t, independently, is 1-6; W is O, S, or NRc; each of L1, L3, L5, L7, and L9 independently, is a bond, O, S, or NRd; each of L2, L4, L6, L8, and L10, independently, is a bond, O, S, or NRe; and V is ORf, SRg, or NRhRi, each of Rb, Rc, Rd, Re, Rf, Rg, Rh, and Ri, independently, being H, OH, a C1-C10 oxyaliphatic radical, a C1-C10 monovalent aliphatic radical, a C1-C10 monovalent heteroaliphatic radical, a monovalent aryl radical, or a monovalent heteroaryl radical.

US Pat. No. 10,792,305

THERAPEUTIC IMMUNE MODULATION USING NOBLE GAS COMPOSITIONS

Nobilis Therapeutics, Inc...

1. A method of treating an autism spectrum disorder comprising the steps of: a) identifying a patient with an autism spectrum disorder; and b) administering a noble gas containing composition comprising oxygen and/or air and a proportion by volume of 20 to 70% of a noble gas at a sufficient concentration and frequency to a patient in need thereof to effectively treat said autism spectrum disorder.

US Pat. No. 10,792,301

THERAPEUTIC POLYSACCHARIDE MIDI-GAGR AND RELATED MATERIALS AND METHODS

The University of Toledo,...

1. A pharmaceutical composition formulated for one or more of:enhancement of bone cell formation from human adult mesenchymal stem cells, and treating alterations in neuronal cells;
the composition comprising a low acyl gellan gum (LA-GAGR) cleavage product, wherein the LA-GAGR cleavage product is midi-GAGR having an average molecular weight of about 4,775 g/mol;
wherein the LA-GAGR cleavage product is present in a therapeutic amount sufficient to enhance bone cell formation from human adult mesenchymal stem cells or treat alterations in neuronal cells.

US Pat. No. 10,792,300

DENDRITIC CELL IMMUNE RECEPTOR ACTIVATOR, METHOD FOR ACTIVATING DENDRITIC CELL IMMUNE RECEPTOR, OSTEOCLAST FORMATION INHIBITOR, METHOD FOR INHIBITING OSTEOCLAST FORMATION, DENDRITIC CELL DIFFERENTIATION/PROLIFERATION INHIBITOR, METHOD FOR INHIBITING DENDR

TOKYO UNIVERSITY OF SCIEN...

1. A method for activating dendritic cell immune receptor (DCIR), comprising causing a dendritic cell immune receptor activator to contact DCIR on an osteoclast cell,the dendritic cell immune receptor activator comprising a compound having a sugar chain as an active ingredient, the sugar chain having a basic structure represented by the following formula:

wherein, in the formula, a sialic acid does not exist at two non-reducing terminals, and each of x and y independently represents 3 or 4.

US Pat. No. 10,792,293

TOPICAL NANODRUG FORMULATION

1. A topical formulation for treating one or more dermal diseases, comprising:a nano-structured lipid carrier (NLC) matrix, the NLC matrix including:
a solid lipid,
a liquid lipid, comprising oleic acid and
at least two emulsifier agents, including a lipophilic emulsifier and a hydrophilic emulsifier;
spironolactone as an active ingredient incorporated within the NLC matrix, forming spironolactone-loaded NLC (SP-NLC) particles with a particle size in a range of less than 300 nanometers; and
a medium, including:
an essence, including rosemary or lavender,
a preservative agent,
a gelling agent, and
deionized water,wherein:the dermal disease comprises Acne, comprising mild to moderate Acne vulgaris,
the SP-NLC particles are dispersed within the medium, forming a SP-NLC gel or lotion,
the solid lipid is present with an amount of less than 4 percent based on the weight of the SP-NLC gel or lotion,
the liquid lipid is present with an amount of 2 percent or less based on the weight of the SP-NLC gel or lotion,
the spironolactone is present with a therapeutically effective amount of 1.0 percent by weight of the SP-NLC gel or lotion,
the preservative agent is present in a range of about 0.1 to 0.2 percent by weight of the SP-NLC gel or lotion,
the gelling agent is present in a range of about 0.1 to 1.0 percent by weight of the SP-NLC gel or lotion, and
the deionized water is present with an amount of 80 percent or more based on the weight of the SP-NLC gel or lotion.

US Pat. No. 10,792,292

ABIRATERONE PRODRUGS

Propella Therapeutics, In...

1. A compound of Formula I, or a pharmaceutically acceptable salt thereof,
wherein R1 is R10, O—R10, or NHR10,
wherein R10 is selected from:
a C8-30 alkyl; a C7-30 alkenyl; a C7-30 alkynyl; an alkyl substituted with a cycloalkyl, which has a total number of carbons between 5 and 16; an alkyl substituted with a phenyl, which has a total number of carbons between 7 and 16; a cycloalkyl optionally substituted with one or more alkyl, which has a total number of carbons between 5 and 16; and

US Pat. No. 10,792,283

QUINOLINE ANALOGS AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

HANGZHOU ZHENGXIANG PHARM...

1. A selective phosphoinositide 3-kinase delta (PI3?) inhibitor compound having a structure of formula (A), or a pharmaceutically acceptable salt, or solvate thereof:
wherein X is N or CH;
R1 and R2 are each independently H, F, or SO2Me, and
R3 is F or Cl.

US Pat. No. 10,792,280

PHARMACEUTICAL COMPOSITION COMPRISING AMODIAQUINE AND ANTI-DIABETES DRUG AS EFFECTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF DIABETES

NOVMETAPHARMA CO., LTD., ...

1. A method for treating type 2 diabetes responding to peroxisome proliferator-activated receptor-gamma (PPAR-?) activation and also treating a disease selected from the group consisting of obesity, dyslipidemia, a cardiovascular disease, fatty liver, a combination thereof which respond to peroxisome proliferator-activated receptor-alpha (PPAR-?) activation,the method comprising administering, to a subject in need thereof,
(a) amodiaquine of the following Formula 1 or a pharmaceutically acceptable salt thereof:
and(b) one or more antidiabetic drugs selected from the group consisting of:
a biguanide drug selected from the group consisting of metformin, buformin, and phenformin;
an insulin sensitizer selected from the group consisting of troglitazone, ciglitazone, rosiglitazone, pioglitazone, and englitazone;
a dipeptidyl peptidase 4 (DPP-4) inhibitor selected from the group consisting of sitagliptin, linagliptin, vildagliptin, gemigliptin, saxagliptin, alogliptin, teneligliptin, anagliptin, and evogliptin;
a sodium-glucose co-transporter 2 (SGLT2) inhibitor selected from the group consisting of dapagliflozin, canagliflozin, empagliflozin, ipragliflozin, tofogliflozin, luseogliflozin, remogliflozin, remogliflozin etabonate, and ertugliflozin;
a glucagon-like peptide 1 (GLP1) agonist selected from the group consisting of exenatide, lixisenatide, liraglutide, albiglutide, and dulaglutide;
an insulin secretagogue selected from the group consisting of glybenclamide (glyburide), glipizide, gliclazide, glimepiride, tolazamide, tolbutamide, acetohexamide, carbutamide, chlorpropamide, glibornuride, gliquidone, glipentide, glisolamide, glisoxepide, glyclopyamide, glycylamide, glipentide, repaglinide, and nateglinide;
an ?-glucosidase inhibitor selected from the group consisting of acarbose, voglibose, emiglitate, and miglitol;
a cannabinoid receptor 1 antagonist selected from the group consisting of rimonabant, otenabant, ibinabant, and surinabant; and
a composition comprising cyclo-his-pro, or a zinc salt and cyclo-his-pro.

US Pat. No. 10,792,276

UROLITHINS AS IMMUNE RESPONSE ENHANCERS

Amazentis SA, Ecublens (...

1. A method of raising an immune response to an antigen or enhancing, or augmenting an immune response to an antigen, comprising administering to a subject in need thereof an effective amount of a compound of formula (I)wherein:the subject is a human or an animal;
the immune response of the subject to an antigen is raised, enhanced, or augmented; and
A, B, C, D, W, X, Y and Z are each independently selected from H and OH;
or a salt thereof.

US Pat. No. 10,792,275

INHIBITING BINDING OF INFLUENZA-VIRUS PB2 SUBUNIT TO RNA CAP

Sinoclone Ltd, Hong Kong...

1. A method of inhibiting the binding of an influenza-virus PB2 subunit to an RNA cap, the method comprising the step of:exposing the PB2 subunit to a quantity of an antiviral compound;
where the antiviral compound is selected from the group consisting of the following compounds:

US Pat. No. 10,792,274

DEHYDROACETIC ACID (DHAA) AND DERIVATIVE FOR USES IN TREATING CANCER

Emory University, Atlant...

1. A method of treating cancer or a neoplasm comprising administering an effective amount of dehydroacetic acid, or its derivative, or their salts thereof to a subject in need thereof,wherein the dehydroacetic acid derivative is of the following formula:

wherein,
W is O;
X is O, S, or NH;
Y is O, S, or NH;
Z is OH, SH, or NH2 optionally substituted with one or more, the same or different R10;
R1 is hydrogen, halogen, alkyl, halogenated alkyl, formyl, carboxy, hydroxyalkyl, thioalkyl, aminoalkyl, alkanoyl, alkoxycarbonyl, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, benzoyl, benzyl, aryl, or heterocyclyl, wherein R1 is optionally substituted with one or more, the same or different R10;
R2 is hydrogen, halogen, alkyl, halogenated alkyl, formyl, carboxy, hydroxyalkyl, thioalkyl, aminoalkyl, alkanoyl, alkoxycarbonyl, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, benzoyl, benzyl, aryl, or heterocyclyl, wherein R2 is optionally substituted with one or more, the same or different R10;
R3 is hydrogen, alkyl, halogenated alkyl, formyl, carboxy, hydroxyalkyl, thioalkyl, aminoalkyl, alkanoyl, alkoxycarbonyl, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, benzoyl, benzyl, aryl, or heterocyclyl, wherein R3 is optionally substituted with one or more, the same or different R10; and
R10 is alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, hydroxyalkyl, alkylthio, thioalkyl, alkylamino, aminoalkyl, (alkyl)2amino, alkanoyl, alkoxycarbonyl, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, benzoyl, benzyl, aryl, or heterocyclyl, wherein R10 is optionally substituted with one or more, the same or different R11; and
R11 is halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, isopropoxy, tert-butoxy, hydroxymethyl, hydroxyethyl, thiomethyl, thioethyl, aminomethyl, aminoethyl, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, benzoyl, benzyl, carbocyclyl, aryl, or heterocyclyl.

US Pat. No. 10,792,272

METHODS FOR TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTIONS

THE SCRIPPS RESEARCH INST...

1. A method of treatment of a Clostridium difficile infection in a mammal, comprising administering to the mammal an effective dose of a compound of formula (I)
wherein X is halo or H, provided at least one X is halo, wherein the ring bearing X is optionally further substituted with halo;
wherein Ar is phenethyl, unsubstituted or independently substituted with one or more halo, (C1-C4)alkyl, cyano, or nitro groups.

US Pat. No. 10,792,268

METHODS OF SUSTAINING DIETARY KETOSIS AND ITS EFFECTS ON LIPID PROFILE

University of South Flori...

1. A method of suppressing hunger in a human patient in need thereof comprising: administering a therapeutically effective amount of a composition comprising a ketogenic agent to elevate one or more ketone bodies for at least four (4) hours and suppress hunger in the human patient;wherein the ketogenic agent is R,S-1,3-butanediol acetoacetate monoester; R,S-1,3-butanediol diacetoacetate ester; or a combination thereof;
wherein administration of the composition induces ketosis in the human patient, and
wherein the human patient consumes an average of greater than 50 g of carbohydrate per day.

US Pat. No. 10,792,254

EXTRUDED EXTENDED RELEASE ABUSE DETERRENT PILL

Pharmaceutical Manufactur...

1. An oral, extended release, abuse deterrent pill comprising a drug and(i) 30 wt % to 50 wt % of polyethylene oxide having an average molecular weight between 50K Daltons and 150K Daltons;
(ii) 8 wt % to 60 wt % of a controlled release agent;
(iii) 0.2 wt % to 20 wt % polyethylene glycol, wherein the polyethylene glycol has an average molecular weight of 3K to 9K Daltons;
wherein the drug is not oxymorphone, and has an extended release profile,
wherein the pill has at least 50 wt % of particles with a particle size greater than 0.5 mm following physical or mechanical manipulation of the pill, and
wherein the pill is a formed, uniform extrudate having a uniform blend of the drug, the polyethylene oxide, the controlled release agent, and the polyethylene glycol, and is directly formed from an extrusion process.

US Pat. No. 10,792,253

PHARMACEUTICAL COMPOSITIONS

Shin Nippon Biomedical La...

1. An intranasal pharmaceutical powder composition, wherein the intranasal pharmaceutical powder composition comprises particles that comprise an active agent, a carrier, and at least one member selected from the group consisting of a thickening agent, a pH adjusting agent, a sugar alcohol, and any combination thereof, and wherein:the active agent comprises dihydroergotamine (DHE) or a pharmaceutically acceptable salt thereof, indomethacin or a pharmaceutically acceptable salt thereof, or testosterone or a pharmaceutically acceptable salt thereof;
the carrier comprises a microcrystalline cellulose, wherein the microcrystalline cellulose is at least partially coated with the active agent;
at least about 20 percent by weight of the active agent in the particles is amorphous as determined by X-ray diffraction;
when the active agent has a crystalline form, a solubility of the active agent in a crystalline form in an aqueous liquid ranges from about 0.1 ?g/mL to about 1 mg/mL in water at a temperature of 37±0.5° C.;
the particles have an average particle size of about 10 microns to about 300 microns, as measured by laser diffraction; and
when the intranasal pharmaceutical powder composition is administered to a human subject, a pharmacokinetic parameter of the active agent increases by at least about 15%, compared to a corresponding composition that comprises the active agent that is in a crystalline form when administered intranasally to a comparable human subject, as measured by a same method, and wherein the pharmacokinetic parameter comprises AUC0-10min, AUC0-15min, AUC0-30min, Cmax, or any combination thereof.

US Pat. No. 10,792,249

HIGH DRUG LOADING PHARMACEUTICAL COMPOSITIONS

AcrysPharm LLC, Scotch P...

1. A pharmaceutical composition comprising:an active pharmaceutical ingredient; and
pharmaceutically acceptable glass-solution forming additives, and/or
pharmaceutically acceptable eutectic-mixture forming additives,wherein the active pharmaceutical ingredient and the pharmaceutically acceptable additives are present in the form of a hybrid solid dispersion consisting of a uniformly distributed solid dispersion of:a crystalline-suspension; and
a glass-solution and/or a eutectic-mixture,wherein the active pharmaceutical ingredient is present in an amount of from more than 50% w/w to about 90% w/w with respect to the total amount of the active pharmaceutical ingredient and the pharmaceutically acceptable glass-solution forming and/or eutectic-mixture forming additives in the pharmaceutical composition,wherein about 50% w/w to about 95% w/w of the active pharmaceutical ingredient is dispersed in the crystalline-suspension and the remaining active pharmaceutical ingredient is dispersed in the glass-solution and/or the eutectic-mixture,wherein crystalline active pharmaceutical ingredient exists in a nano/micro particle size range and is uniformly distributed in the hybrid solid dispersion, andwherein amorphous active pharmaceutical ingredient, when present, is uniformly distributed in the hybrid solid dispersion,wherein the composition is prepared by a process comprising:i) generating a uniform suspension of nano/micro size particles of the active pharmaceutical ingredient's crystals in one or more solvents containing partially dissolved active pharmaceutical ingredient and fully dissolved pharmaceutically acceptable glass-solution forming and/or eutectic-mixture forming additives; and
ii) evaporating the solvents from the suspension to obtain dry solid particles.

US Pat. No. 10,792,241

COSMETIC PROCESS FOR TREATING KERATIN MATERIALS WITH A MALEIC ANHYDRIDE ETHYLENIC POLYMER

1. A cosmetic process for treating keratin materials, comprising:either sequentially applying to the keratin materials 1) a composition comprising a maleic anhydride ethylenic polymer and 2) at least one amine component chosen from an amine compound chosen from polyamine compounds bearing several primary amine and/or secondary amine groups and amino alkoxysilanes, and a composition containing the amine compound and comprising a physiologically acceptable medium;
or topically applying to the keratin materials a composition derived from mixing 1) a composition comprising a maleic anhydride ethylenic polymer and 2) at least one amine component chosen from an amine compound chosen from amino alkoxysilanes, and a composition containing the amine compound and comprising a physiologically acceptable medium;
the ethylenic polymer being a random or gradient polymer derived from the polymerization of:
(a) 45% to 95% by weight, relative to the total weight of monomers, of at least one ethylenic monomer bearing a C8 to C22 linear or branched alkyl group;
(b) 5% to 25% by weight of maleic anhydride; and
(c) 0 to 50% by weight of at least one additional monomer chosen from:
(i) polydimethylsiloxane silicone monomers bearing a mono(meth)acryloyloxy end group of formula (I) below:

in which:
R8 denotes a hydrogen atom or a methyl group;
R9 denotes a linear or branched divalent hydrocarbon-based group containing from 1 to 10 carbon atoms and optionally containing one or two ether bonds —O—;
R10 denotes a linear or branched alkyl group containing from 1 to 10 carbon atoms; and
n denotes an integer ranging from 1 to 300; and
(ii) linear or branched C1-C6 alkyl (meth)acrylate or C6-C12 cycloalkyl (meth)acrylate non-silicone monomers;
the compositions used being anhydrous when the amine compound is an amino alkoxysilane.

US Pat. No. 10,792,240

SKINCARE PRODUCT AND METHOD OF PREPARATION THEREOF

1. A skincare product configured to remove iron from the skin surface of a user, the skincare product comprising:a matrix and core components, the core components consisting of a reducing agent and a precipitating agent, wherein:
the molar ratio of the reducing agent to the precipitating agent is 1:5;
the core components in the skincare product represents 5%-10% w/w;
the pH values of the skincare product is between 6.6 and 7.4; and
wherein the reducing agent is selected from the group consisting of vitamin C, vitamin E, glutathione, vitamin A, vitamin D, and their derivatives; and
wherein the precipitating agent is selected from the group consisting of calcium carbonate, pearl powder, magnesium carbonate, barium carbonate, calcium phosphate, magnesium phosphate, barium phosphate, calcium silicate, magnesium silicate, and barium silicate.

US Pat. No. 10,792,238

COSMETIC COMPOSITION HAVING HIGH DOSAGE FORM STABILITY

AMOREPACIFIC CORPORATION,...

1. Method for inhibiting crystallization and crystal precipitation of kojyl methylenedioxycinnamate represented by the following Formula 1 as an active ingredient in a cosmetic composition for up to 10 weeks, comprising the step of adding a mannosylerythritol lipid (MEL) represented by the following Formula 2 to the cosmetic composition,wherein the mannosylerythritol lipid acts as a stabilizer for the kojyl methylenedioxycinnamate of Formula 1 in the cosmetic composition,
wherein the kojyl methylenedioxycinnamate is included at a content of 0.05 to 0.25% by weight, based on the total weight of the cosmetic composition,
wherein the mannosylerythritol lipid is included at a content of 0.25 to 5.0% by weight, based on the total weight of the cosmetic composition,
wherein the kojyl methylenedioxycinnamate and the mannosylerythritol lipid are included at a weight ratio of 1:3.3 to 1:10:

wherein R1 and R2 are the same or different from each other, and each independently a C2 to C24 aliphatic acyl group, and
R3 and R4 are the same or different from each other, and each independently an acetyl group or hydrogen.

US Pat. No. 10,792,234

COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND AN OILY PHASE COMPRISING AT LEAST ONE POLYALKYLENE GLYCOL

1. A cosmetic or dermatological composition comprising, in a physiologically acceptable medium:a) at least one merocyanine corresponding to one of the following formulae (1) and (2) or one of the E/E- or E/Z-geometrical isomer forms thereof:

in which:
R1 and R2 are, independently of each other, hydrogen; a C1-C22 alkyl group, a C2-C22 alkenyl group or a C2-C22 alkynyl group, it being possible for these groups to be substituted with at least one hydroxyl group or to be interrupted with at least one —O—; or alternatively R1 and R2 form, together with the nitrogen atom which connects them, a —(CH2)n— ring which may optionally be interrupted with —O— or —NH—;
R3 is a group —(C?O)OR6 or a group —(CO)NHR6;
R6 is a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alkynyl group, a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, it being possible for the said groups to be substituted with one or more OH groups;
R4 and R5 are hydrogens; or R4 and R5 form a —(CH2)n— ring which may be substituted with a C1-C4 alkyl group and/or interrupted with one or more —O— or with —NH—;
n is a number between 2 and 7;
R7 and R8 are, independently of each other, hydrogen; a C1-C22 alkyl group, a C2-C22 alkenyl group or a C2-C22 alkynyl group, it being possible for the said groups to be interrupted with one or more O and/or substituted with one or more OH groups; a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, it being possible for the said groups to be interrupted with one or more —O—;
or alternatively R7 and R8 form, together with the nitrogen which connects them, a —(CH2)n— ring which may be interrupted with one or more —O—;
R9 and R10 are hydrogen; or R9 and R10 form a —(CH2)n— ring which may be substituted with a C1-C4 alkyl and/or interrupted with an —O— or —NH—;
A is —O— or —NH;
R11 is a C1-C22 alkyl group; a C2-C22 alkenyl group; a C2-C22 alkynyl group; a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, it being possible for the said groups to be interrupted with one or more O; or a C1-C22 alkyl group or a C2-C22 alkenyl group which is substituted with a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, it being possible for the said C3-C22 cycloalkyl group or C3-C22 cycloalkenyl group to be interrupted with one or more —O—;
and
b)
at least one oily phase comprising at least one polyalkylene glycol of formula (4) below:
R1—(O—CH2—CH2)x—(O—CH(CH3)—CH2)y—O—R2  (4)
in which
1) either R1 and R2 denote hydrogen,
x and y, which may be identical or different, may range from 0 to 12, with x+y ranging from 3 to 15
or 2) R1 denotes a C1-C4 alkyl group, R2 denotes hydrogen and x is equal to zero and y ranges from 2 to 5
or 3) R1 denotes a linear or branched C8-C22 alkyl or alkenyl radical or mixture of radicals, a (C8-C9)alkylphenyl radical, a radical R3CONH—CH2-CH2- with R3 denoting a linear or branched C9-C21 alkyl or alkenyl radical, x is an integer or decimal number (mean value) which ranges from 2 to 15, y is equal to zero and
R2 represents the group —CH2COOM
with M denoting H, ammonium, Na, K, Li, Mg or a monoethanolamine or triethanolamine residue.

US Pat. No. 10,792,233

METHODS AND FORMULATIONS FOR CURLING HAIR

OLAPLEX, INC., Boston, M...

1. A method comprising:(a) applying to hair a formulation comprising one or more hydroxide-containing agents and an active agent of Formula II:

wherein Z is a linker or is absent and the linker is not a polymer; m and n are each an integer independently selected from 1-6, and the sum of m+n is equal to or greater than 2;
B is a functional group capable of forming a covalent bond with a nucleophile and B is independently selected from the group consisting of:

wherein each R is independently selected from the group consisting of hydrogen, C1-6 alkyl groups, aryl groups, and ionizable functional groups and Z? is oxygen (O), NH or is absent, and G is carbon (C) and g is 1, or G is sulfur (S) and g is 2;
A is an ionizable functional group independently selected from the group consisting of carboxylic acids, sulfonic acids, phosphonic acids, and amines;
wherein the formulation has a pH of 10 or greater, and
(b) reshaping the hair;
wherein the method is substantially free of a sulfur-containing reducing agent; and
wherein steps (a) and (b) are not followed by an oxidizing step.

US Pat. No. 10,792,227

CONTAINER GRIPPING AID

1. A device comprising a container and a container gripping aid for the container, the container having an exterior side wall and a bottom, the bottom of the container being bulbous and including an upper shoulder, the container gripping aid comprising:a jacket for reception of the container, the jacket having a mesh configuration, the jacket being resiliently deformable and being formed by a stiff but flexible material, and the jacket having a bottom with an inner face shaped to receive and fit a bottom of the container;
retaining means for securing the jacket in engagement with the container such that a side wall of the jacket is supported spaced-apart from the exterior side wall of the container, the retaining means comprising a base support for engagement with the bottom of the container;
means for gripping the jacket to support the container, the jacket gripping means comprising a plurality of perforations or through holes in the jacket to facilitate gripping the jacket to support the container; and
one or more inwardly directed spacer ribs on an inner wall of the jacket to maintain the side wall of the jacket spaced-apart from the exterior side wall of the container in use, the one or more inwardly directed spacer ribs including first and second spacer ribs that face one another and define an opening that is smaller than a diameter of the bottom of the container, and the first and second spacer ribs being configured to deflect to allow passage of the bottom of the container during insertion of the container into the jacket and are configured to engage an upper shoulder of the bottom of the container.

US Pat. No. 10,792,226

REFILL AND DOSAGE MANAGEMENT DEVICES AND ASSOCIATED SYSTEMS AND METHODS FOR USE WITH COMPUTERIZED ORAL PRESCRIPTION ADMINISTRATION DEVICES

BERKSHIRE BIOMEDICAL, LLC...

1. An apparatus, comprising:a housing having a structure sized and shaped to receive at least a portion of a mouthpiece of an intended user;
a dispensing unit coupled to the housing, the dispensing unit configured to dispense a substance into a reservoir of the mouthpiece; and
an identification unit configured to, based on a communication from the mouthpiece, determine an identity of the intended user when the mouthpiece of the intended user is coupled to the housing.

US Pat. No. 10,792,225

SECURE MEDICATION DISPENSER

1. A secure medication dispenser, comprising:a housing including a top edge and a bottom edge, wherein said top edge is shorter than said bottom edge, said housing further including a first side edge and a second side edge being parallel to each other and extends upwardly from said bottom edge, said housing further including a first slanting edge and a second slanting edge each slanting inwardly and extending to meet said top edge, a rear plate pivotally mounted to said first slanting edge of said housing adapted to serve as a lid, a face plate abutting with said second slanting edge, said housing further including a handle extending from a sidewall of said housing, said rear plate further including a first loading point, a second loading point, and a third loading point each having a circular shape, wherein said housing comprises:
a time to release a specified dosage of each of a plurality of medications;
an environment control system configured to control one or more physical environmental characteristics for said plurality of medications inside said housing to preserve corresponding potencies;
a plurality of authorization mechanisms located on said face plate of said housing, said face plate further including a first dispensing point and a second dispensing point having a circular shape; and
a plurality of trays located within said housing adapted to hold the plurality of medications.

US Pat. No. 10,792,224

SYSTEMS AND METHODS FOR PORTABLE PILL DISPENSERS

Intent Solutions, Inc., ...

1. A portable pill dispenser, comprising:a container configured to house at least one pill therein;
a housing attachable to the container, wherein the housing comprises a dispensing opening;
a dispensing mechanism disposed within the housing, wherein the dispensing mechanism is configured to dispense the at least one pill from the container to the dispensing opening;
a ramp disposed within the housing, wherein the ramp is configured to direct the at least one pill to the dispensing mechanism;
a verification mechanism disposed about the housing, wherein the verification mechanism is configured to activate the dispensing mechanism; and
a control panel disposed within the housing, wherein the control panel is in electrical communication with the dispensing mechanism and the verification mechanism,
wherein the dispensing mechanism comprises (i) a barrel positioned at an outlet of the ramp, wherein the barrel comprises a cavity configured to receive the at least one pill therein, (ii) a removable insert disposable within the cavity for adjusting the size and/or shape of the cavity, and wherein the barrel is rotatable and angled such that rotation of the barrel dispenses the at least one pill from the cavity to the dispensing opening.

US Pat. No. 10,792,223

PILL DISPENSING APPARATUS FOR USE WITH BLISTER PILL PACKAGES

Nathaniel Paul Lamaster, ...

1. A pill dispensing apparatus for use to dispense a pill from a blister package with enhanced efficiency, the pill dispensing apparatus comprising:a base assembly comprising an interior cavity formed by an upper plate coupled to a lower housing, the upper plate partially extending over the lower housing to form a spout in the lower housing connected to the interior cavity of the base assembly, the upper plate comprising an opening continuously connected to the interior cavity of the base assembly;
an arm pivotably mounted to the base assembly and comprising a lower member with a post protruding downward toward the base assembly and aligned with the opening in the upper plate of the base assembly;
a spring comprising a first end coupled to the arm and a second end coupled to the upper plate of the base assembly; and
a tubular cover disposed around the spring and in contact with the lower member of the arm and upper plate of the base assembly, the tubular cover comprising a plurality of protrusions configured to permit the tubular cover to compress and extend in response to movement of the arm relative to the base assembly;
wherein the apparatus is configured to receive the blister package between the base assembly and arm with the pill in the blister package aligned with the post of the arm and opening in the upper plate of the base assembly, wherein pivotal movement of the arm toward the base assembly to a closed position allows the post of the arm to push the pill in the blister package through the opening in the upper plate of the base assembly, thereby allowing the pill to travel in the internal cavity of the base assembly for a disposal out of the spout.

US Pat. No. 10,792,222

PILL CRUSHER AND CORRESPONDING METHODS

Medline Industries, Inc.,...

1. A crushing device, comprising:a base;
a first sidewall and a second sidewall extending distally from the base; and
a crushing assembly coupled between the first sidewall and the second sidewall, the crushing assembly comprising:
a first crushing plate pivotally coupled about a first pivot defining a first axis;
a lever coupled to the first crushing plate, the lever selectively movable between a first position and a second position angularly displaced about the first axis from the first position to rotate the first crushing plate in a first radial direction about the first axis;
a second crushing plate pivotally coupled about a second pivot defining a second axis; and
a cog insert, coupled between the first crushing plate and the second crushing plate;
the cog insert causing the second crushing plate to rotate in a second radial direction, opposite the first radial direction, when the lever moves from the first position to the second position.

US Pat. No. 10,792,221

DISPENSING CONTAINERS

MEDI-Clear Ltd, Hull (GB...

9. A container for storing and dispensing consumer products, comprising:a tray having a generally planar top surface into which has been formed a plurality of discrete cavities for receiving consumer products; and
the tamper-evident seal of claim 1, wherein the cover film is secured to the generally planar top surface of the tray and seals the plurality of discrete cavities to retain consumer products in the plurality of discrete cavities,
wherein the main portion of each barrier patch overlies an associated cavity of the plurality of discrete cavities.

US Pat. No. 10,792,220

MEDICATION DISPENSING SYSTEM

Accredo Health Group, Inc...

1. A medication packaging assembly for individual dosing comprising:a plurality of packets each configured to store at least one medication;
a first dosing bag configured to hold a first packet of the plurality of packets, and the first dosing bag being further configured to store a first specific medication dose defined by the first packet of the plurality of packets;
a second dosing bag configured to hold a second packet of the plurality of packets, and the second dosing bag being further configured to store a second specific medication dose defined by the second packet of the plurality of packets; and
a plurality of dosing bag assemblies each configured to store at least one of the first dosing bag and the second dosing bag joined at a dosing bag separation border, the plurality of dosing bag assemblies being connected together at a binding area to form a package, wherein the binding area includes a stub for each of the first dosing bag and the second dosing bag with the stub being connected to the respective one of the first dosing bag and the second dosing bag at the dosing bag separation border to provide a selectable separation location for the first and second dosing bags from the stubs at the binding area, the stubs including indicia related to the first and second dosing bags and remaining at the binding area with the first and second dosing bags being removed.

US Pat. No. 10,792,219

IMPLANTABLE ELECTROACUPUNCTURE SYSTEM AND METHOD

Valencia Technologies Cor...

1. A method, comprising:generating, by an implantable stimulator, stimulation sessions at a duty cycle that is less than 0.05, wherein
the duty cycle is a ratio of T3 to T4,
each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and
the implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms; and
applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a patient.

US Pat. No. 10,792,218

FLEXIBLE LINER WITH INNER AND OUTER LAYERS FOR USE WITH A LIQUID-RECEIVING BASIN

Contego Spa Designs, Inc....

1. A liner for use with a basin to contain a liquid, the basin having a bottom base, an upstanding basin wall extending upwardly from the bottom base, an inside face of the basin defined by the bottom base and the upstanding basin wall delimiting an interior volume of the basin where the liquid is received, and an air discharge apparatus arranged for supplying pressurized air to be discharged into the liquid, the liner comprising:a first body of flexible plastic having:
an outer face for resting against the inside face of the basin; and
an inner face opposite to the outer face;
a second body of flexible plastic having an interior face and an opposite exterior face;
the interior face of the second body of flexible plastic being joined to the inner face of the first body of flexible plastic which collectively define an interface of the first and second bodies of flexible plastic;
the joined first and second bodies of flexible plastic forming a bag, which has a peripheral edge defining an open top of the bag, for placing in the basin in a working configuration of the liner in which the bag is covering the inside face of the basin with the outer face of the first body of flexible plastic in engagement with the inside face of the basin;
the exterior face of the second body of flexible plastic delimiting an interior of the bag in which the liquid is to be contained;
the bag having a thickness measured between the outer face of the first body of flexible plastic and the exterior face of the second body of flexible plastic;
the bag including an air conduit adapted for guiding the pressurized air from the air discharge apparatus to the interior of the bag;
the air conduit having a starting end which is operatively connectable to the air discharge apparatus to receive the pressurized air therefrom;
the air conduit having a discharge portion defined within the thickness of the bag that is fluidically communicated with the interior of the bag for discharging the pressurized air thereto;
at least a portion of the air conduit between the starting end and the discharge portion extending within the thickness of the bag;
wherein a length of said portion of the air conduit is formed at the interface of the first and second bodies of flexible plastic such that a circumferential wall of said length of the air conduit is defined in part by the inner face of the first body of flexible plastic and in part by the interior face of the second body of flexible plastic; and
the first body of flexible plastic being substantially imperforate so as to isolate the interior of the bag from the inside face of the basin in the working configuration of the liner.

US Pat. No. 10,792,217

COLD-HOT MIXED TYPE HUMIDIFYING FACIAL STEAMER

1. A cold-hot mixed type humidifying facial steamer, comprising:a shell, wherein a water tank assembly is arranged on one side of an inner chamber of the shell, wherein a fan is arranged on the other side of the inner chamber of the shell, wherein a cold humidifying mist chamber is arranged below the water tank assembly, wherein the cold humidifying mist chamber is connected with a hot humidifying steam chamber through a water pipe, wherein an atomizer is arranged underneath the cold humidifying mist chamber, wherein the top of the cold humidifying mist chamber is connected with one side of the bottom of an herb feeding chamber through a cold mist conveying pipe, wherein a heating element is arranged in the hot humidifying steam chamber, wherein the hot humidifying steam chamber is connected with the other side of the bottom of the herb feeding chamber through a hot steam conveying pipe, wherein a porous herb bag mounting base is arranged in the herb feeding chamber, wherein a delivering pipe is arranged at the top of the herb feeding chamber, wherein a flange plate is formed at the top end surface of the delivering pipe, wherein the top of the flange plate is connected with a first venting plate and a second venting plate that interact with each other, wherein a sliding rail is arranged on the periphery of the first venting plate, wherein a plurality of sliding blocks is arranged on the second venting plate, wherein the first venting plate and the second venting plate can rotate relative to each other through the interaction of the sliding blocks and the sliding rail, wherein a plurality of venting holes is formed in both the first venting plate and the second venting plate; wherein the facial steamer is provided with a face cleaning device, wherein one side of the shell is arranged in a receiving groove used for receiving the face cleaning device, wherein the bottom of the face cleaning device is rotatably installed in the receiving groove through a rotating shaft, wherein the face cleaning device comprises a rod body, a rotating table and a face cleaning sponge, wherein a rotating motor is arranged in the rod body, and a center-controlled shaft body is arranged on the lower surface of the rotating table, wherein a gear ring is fixedly arranged on the shaft body, wherein a gear meshed with the gear ring is arranged in the rod body, wherein the gear is driven by the rotating motor fixed on the inner wall of the rod body, and a fixing groove is formed in the rotating table, wherein the face cleaning sponge is fixed in the fixing groove.

US Pat. No. 10,792,216

CHEST COMPRESSION DEVICE

OSLO UNIVERSITETSSYKEHUS ...

1. A mechanical chest compression device, comprising:a support structure structured to position a chest compressor above a chest of a patient;
the chest compressor mounted on the support structure, the chest compressor including a piston;
an actuator configured to drive the piston to extend to apply chest compression to the chest of the patient;
a first lateral chest support attached to a chest facing side of the support structure at a lateral position on a first side of the chest when the device is in use; and
a second lateral chest support attached to the chest facing side of the support structure at a lateral position on a second side of the chest of the patient when the device is in use, the second lateral chest support moveable from a first, retracted position to a second, extended position, the movement of the second lateral chest support to the second position being synchronized with extension of the piston applying at least one chest compression, the second lateral chest support structured to apply lateral compression to the lateral position on the second side of the chest of the patient in the second, extended position.

US Pat. No. 10,792,215

MECHANICAL CPR DEVICE

PHYSIO-CONTROL, INC., Re...

11. A method for performing mechanical cardiopulmonary resuscitation (CPR), the method comprising:attaching a mechanism to a torso of a patient;
determining a reference position by:
extending the mechanism to a first position in contact with the torso,
extending the mechanism beyond the first position then retracting the mechanism to the first position,
retracting the mechanism away from the first position until a threshold is exceeded, and
then extending the mechanism to a point when the threshold is no longer exceeded and set the point as the reference position;
extending the mechanism from the reference position to a first distance below the reference position;
retracting the mechanism from the first distance to a second distance above the reference position; and
extending the mechanism from the second distance to the reference position.

US Pat. No. 10,792,214

STIMULATION DEVICES AND METHODS OF USE

LELO Inc., San Jose, CA ...

1. A stimulation device configured to stimulate a portion of a body of a user, comprising:a housing having a first end, a second end opposite the first end, a nozzle, and a silicone covering, the silicone covering disposed such that it covers a portion of the first end and a portion of the second end, the housing defining a chamber having a first opening configured to receive said portion of said body, the chamber having a chamber surface that is defined by the silicone covering;
a motor disposed within the housing and configured to generate a stimulation pattern, the motor including a drive shaft disposed adjacent the chamber, the motor configured to transmit the stimulation pattern into the chamber;
a sensor disposed within the housing and adjacent the motor, the sensor configured to detect output produced by the motor;
a controller disposed within the housing and configured to control the motor; and
a battery disposed within the housing configured to provide power to the motor, the sensor, and the controller, the battery being capable of holding a portion of its maximum charge as reserve power, the battery distributing the reserve power to the motor upon the sensor detecting decreased output from the motor.

US Pat. No. 10,792,213

ASSISTANCE APPARATUS

PANASONIC INTELLECTUAL PR...

22. An assistance apparatus comprising:an upper body belt configured to be worn on an upper body of a user;
a first knee belt configured to be worn above a left knee of the user;
a second knee belt configured to be worn above a right knee of the user;
a first wire coupled to a first portion configured of the upper body belt and to the first knee belt, the upper body belt having the first portion to be worn on a front side of the user, the first wire having a longitudinal direction extending from the first knee belt to upper right of the user;
a second wire coupled to the upper body belt and to the first knee belt, the second wire having a longitudinal direction extending from the first knee belt to upper left of the user, the longitudinal direction of the second wire crossing the longitudinal direction of the first wire above the front side;
a third wire coupled to the upper body belt and to the first knee belt, the third wire having a longitudinal direction extending from the first knee belt to upper left of the user;
a fourth wire coupled to a second portion of the upper body belt and to the first knee belt, the upper body belt having the second portion configured to be worn on a back side of the user, the fourth wire having a longitudinal direction extending from the first knee belt to upper right of the user, the longitudinal direction of the third wire crossing the longitudinal direction of the fourth wire above the back side;
a fifth wire coupled to a third portion of the upper body belt and to the second knee belt, the upper body belt having the third portion configured to be worn on the back side, the fifth wire having a longitudinal direction extending from the second knee belt to upper left of the user;
a sixth wire coupled to the upper body belt and to the second knee belt, the sixth wire having a longitudinal direction extending from the second knee belt to upper right of the user, the longitudinal direction of the sixth wire crossing the longitudinal direction of the fifth wire above the back side;
a seventh wire coupled to the upper body belt and to the second knee belt, the seventh wire having a longitudinal direction extending from the second knee belt to upper right of the user;
an eighth wire coupled to an fourth portion of the upper body belt and to the second knee belt, the upper body belt having the fourth portion configured to be worn on the front side, the eighth wire having a longitudinal direction extending from the second knee belt to upper left of the user, the longitudinal direction of the seventh wire crossing the longitudinal direction of the eighth wire above the front side;
motors including a first motor, a second motor, a third motor, a fourth motor, fifth motor, and sixth motor;
a control circuit; and
a sensor that detects whether the second wire is broken and whether the fourth wire is broken,
wherein when the user turns left and the sensor detects that the second wire and the fourth wire are not broken, the control circuit causes the second motor to generate a tension equal to or more than a first value in the second wire using information obtained from a force sensor corresponding to the second motor or a drive amount of the second motor, the fourth motor to generate a tension equal to or more than the first value in the fourth wire using information obtained from a force sensor corresponding to the fourth motor or a drive amount of the fourth motor, the fifth motor to generate a tension equal to or more than the first value in the sixth wire using information obtained from a force sensor corresponding to the sixth wire or a drive amount of the fifth motor, and the sixth motor to generate a tension equal to or more than the first value in the eighth wire using information obtained from a force sensor corresponding to the eighth wire or a drive amount of the sixth motor,
wherein when the user turns left and the sensor detects that the second wire is not broken and the fourth wire is broken, the control circuit causes the second motor to generate a tension equal to or more than the first value in the second wire using information obtained from the force sensor corresponding to the second motor or a drive amount of the second motor, the third motor to generate a tension equal to or more than the first value in the third wire using information obtained from a force sensor corresponding to the third motor or a drive amount of the third motor, the fifth motor to generate a tension equal to or more than the first value in the sixth wire using information obtained from the force sensor corresponding to the sixth wire or a drive amount of the fifth motor, and the sixth motor to generate a tension equal to or more than the first value in the eighth wire using information obtained from a force sensor corresponding to the eighth wire or a drive amount of the sixth motor, and wherein when the user turns left and the sensor detects that the second wire is broken and the fourth wire is not broken, the control circuit causes the first motor to generate a tension equal to or more than the first value in the first wire using information obtained from a force sensor corresponding to the first motor or a drive amount of the first motor, the fourth motor to generate a tension equal to or more than the first value in the fourth wire using information obtained from a force sensor corresponding to the fourth motor or a drive amount of the fourth motor, the fifth motor to generate a tension equal to or more than the first value in the sixth wire using information obtained from a force sensor corresponding to the sixth wire or a drive amount of the fifth motor, and the sixth motor to generate a tension equal to or more than the first value in the eighth wire using information obtained from a force sensor corresponding to the eighth wire or a drive amount of the sixth motor.

US Pat. No. 10,792,212

TORQUE SETTING METHOD AND APPARATUS

Samsung Electronics Co., ...

1. A torque setting method comprising:calculating a torque value based on a rotation angle and a rotation angular velocity of a joint associated with a first limb of a user of a walking assistance apparatus, the calculating including calculating the torque value associated with a current iteration based on a torque value associated with a prior iteration, the rotation angle associated with the current iteration, and the rotation angular velocity associated with the current iteration such that the calculating utilizes the torque value associated with the prior iteration as positive feedback to calculate the torque valve associated with the current iteration; and
setting the torque value associated with the current iteration for the walking assistance apparatus to output a torque corresponding to the torque valve associated with the current iteration.

US Pat. No. 10,792,211

ASSIST DEVICE, ASSIST METHOD, AND RECORDING MEDIUM

PANASONIC INTELLECTUAL PR...

1. An assist device comprising:an upper-body belt to be attached to an upper body of a user;
a first belt to be attached to a right knee of the user;
a second belt to be attached to a left knee of the user;
a first wire that couples the upper-body belt to the first belt;
a second wire that couples the upper-body belt to the first belt, the second wire crossing the first wire;
a third wire that couples the upper-body belt to the second belt;
a fourth wire that couples the upper-body belt to the second belt, the fourth wire crossing the third wire;
a motor coupled to a first end of the first wire, a terminal end of the second wire, a terminal end of the third wire, and a terminal end of the fourth wire;
a sensor; and
a drive controller that (i) causes the motor to apply a first tension greater than or equal to a first threshold value to one of the first wire and the second wire at a first time and a second tension greater than or equal to the first threshold value to one of the third wire and the fourth wire at a second time different from the first time when the assist device assists the user with walking and (ii) causes the motor to apply a third tension greater than or equal to the first threshold value to one of the first wire and the second wire at a third time and a fourth tension greater than or equal to the first threshold value to one of the third wire and the fourth wire at the third time when the assist device detects slacking of the upper-body belt using the sensor.

US Pat. No. 10,792,210

MOVEMENT ASSISTANCE DEVICE

VANDERBILT UNIVERSITY, N...

1. A method of controlling an apparatus comprising an exoskeleton having a hip segment, at least one lower limb, and a plurality of sensors for generating signals indicating a current motion and a current arrangement of at least the exoskeleton, the at least one lower limb comprising a thigh segment and a shank segment for coupling to a lateral surface of a leg of a user, a first powered joint configured for providing motion of the thigh segment relative to the hip segment, and a second powered joint configured for providing motion of the shank segment relative to the thigh segment, at least a portion of the plurality of sensors being disposed on the at least one lower limb, the method comprising:receiving the signals from the plurality of sensors;
based on the signals, determining a current state of the exoskeleton;
estimating a location of a center of pressure of a combination of the user and the exoskeleton based on the signals and inertial properties of the user;
inferring a current intent of the user based on at least the current state of the exoskeleton and a location of the center of pressure relative to at least one reference point for the exoskeleton;
determining a next state for the exoskeleton based at least on the current state and the current intent; and
generating control signals to cause the exoskeleton to transition to the next state.

US Pat. No. 10,792,209

WEARABLE ASSISTIVE DEVICE THAT EFFICIENTLY DELIVERS ASSISTIVE FORCE

LG ELECTRONICS INC., Seo...

1. A wearable assistive device, comprising:a waist support configured to support a waist of a user, the waist support having a first side and a second side;
a first frame coupled to the first side of the waist support, the first frame having a predetermined curvature so as to cover a side of a first hip joint of the user at a first hip joint supporting position;
a second frame coupled to the second side of the waist support, the second frame having a predetermined curvature so as to cover a side of a second hip joint of the user at a second hip joint supporting portion; and
a hip matching assembly that connects the waist support to the first or second frame and interlocks with a movement of the first or second hip joint of the user to move the first or second frame, the hip matching assembly having:
a first rail portion that is provided at the waist support and moves the first frame at the first hip joint supporting position with a movement of the first hip joint, wherein the first rail portion comprises a first guide member including a first guide groove having a predetermined curvature and a first rail member provided at a lower end of the waist support and coupled with the first guide groove, wherein the first rail member is configured to move along the first guide groove in a curved path around a first rotation axis, and
a second rail portion that connects the first rail portion to the first frame and moves the first frame at the first hip joint supporting position with a movement of the first hip joint, wherein the second rail portion comprises a second guide member provided at an inner side of a cover and including a second guide groove having a predetermined curvature.

US Pat. No. 10,792,208

CUSHIONING DEVICES WITH INTERNAL SHEAR ABSORBING LAYER

5 Minds Mobility Inc., O...

1. A mattress for reducing shear, comprising:a first elongate cushioning layer;
a second elongate cushioning layer located below said first elongate cushioning layer;
a shear reduction layer provided between said first elongate cushioning layer and said second elongate cushioning layer, said shear reduction layer defining a shear reduction region configured to support a torso of a user, said shear reduction region extending over a portion of an area between said first elongate cushioning layer and said second elongate cushioning layer, wherein said shear reduction layer is adhered to one of said first elongate cushioning layer and said second elongate cushioning layer, and wherein said shear reduction layer is formed from a low-friction material, such that the other of said first elongate cushioning layer and said second elongate cushioning layer is translatable relative to said shear reduction layer when a shear force is generated under application of pressure to said first elongate cushioning layer within said shear reduction region, thereby internally absorbing the shear force; and
wherein a lower surface of said first elongate cushioning layer is adhered to an upper surface of said second elongate cushioning layer over (i) a first spatially extended region extending from a first longitudinal end of said shear reduction layer to a first longitudinal end of the mattress and (ii) a second spatially extended region extending from a second longitudinal end of said shear reduction layer to a second longitudinal end of the mattress, said first spatially extended region and said second spatially extended region extending beyond said shear reduction layer such that relative translation of said first elongate cushioning layer and said second elongate cushioning layer is permissible within said shear reduction region but prohibited within the first spatially extended region and the second spatially extended region.

US Pat. No. 10,792,207

LATERAL-TO-PRONE SPINE SURGERY TABLE

Allen Medical Systems, In...

1. A surgical patient support system, comprising:a tower base including a pair of spaced apart support towers,
a lateral support top having a head end and a foot end, the lateral support top being configured to support a patient lying in at least lateral and supine positions,
a pair of support brackets, each support bracket of the pair of support brackets being configured for connection to a respective one of the support towers and each including a pair of bracket rails extending in a first direction to a connection end and a prone bracket coupled to one of the bracket rails and extending generally perpendicularly to the first direction, and
a prone support top coupled to the pair of support brackets and arranged generally perpendicularly to the lateral support top and being configured to support a patient in at least a prone position,
wherein each of the pair of support brackets are configured to couple to a respective one of the head and foot ends of the lateral support top and the prone support top to support the lateral support top and the prone support top between the support towers.

US Pat. No. 10,792,206

MEDICAL OR ORGANIZATION CART

FIRMA, Weilheim (DE)

1. A medical or organization cart with a cart body which is formed in particular essentially in the shape of a straight prism, wherein the cart body is provided with at least one corner post which is fixable to the cart body via at least one of a screw, clamping, and/or plug connection, whereinthe corner post is provided with at least one guide element which extends peripherally at the corner post,
at least one of a strap element and/or one adapter may be mounted at the corner post or detached therefrom, for the purpose of attaching accessories at the medical or organization cart,
wherein the strap element and/or the adapter is provided, for the connection with the corner post, with a connection element at an end which is adjacent to the corner post, which may be clamped to the corner post,
wherein the connection element is engaged with the guide element and may be swiveled around the corner post, and
wherein the connection element at least partially encloses the corner post at an angle larger than 180°, in particular larger than 200°.

US Pat. No. 10,792,205

MOTORIZED WHEELCHAIR FOR IMPROVED MOBILITY

1. A mobile wheelchair assembly that enables an occupant to rotate their self from the seated position to the kneeling prone position so that the occupant may use their arms to better reach and grasp without the aid of another person, the wheelchair comprising:a) a mobile base having a frame with front and rear ends;
b) a pair of front wheels connected to the front of the frame and a pair of back wheels connected to the back of the frame, wherein the front wheels, back wheels, or both are connected to and powered by a first electric motor, wherein control of said powered wheels is integrated into a control switch operated by the occupant;
c) a seat assembly connected to the back end of the frame, said seat assembly being capable of adjustment at least upward or downward with the assistance of a second electric motor, wherein control of said seat assembly is integrated into said control switch operated by the occupant;
d) a complete occupant support assembly including at least one leg support and at least one chest support and configurable between at least:
a first configuration in which the leg support is upright; and
a second configuration in which the leg support is rotated forward toward the prone position;
wherein said complete occupant support assembly switches from one configuration to another with the assistance of a third electric motor, wherein control of said complete occupant support assembly is integrated into said control switch operated by the occupant;
e) at least one armrest alongside the seat and capable of adjustment at least upward or downward with the assistance of a fourth electric motor, wherein control of said armrest is integrated into said control switch operated by the occupant;
f) a rotating assembly having said third electric motor connected thereto for applying rotating force to the rotating assembly that can rotate the leg support between at least the first configuration and the second configuration wherein the occupant is rotated from the seated position into the kneeling prone position, wherein control of said rotating assembly is integrated into said control switch operated by the occupant;wherein the occupant may navigate said wheelchair assembly to a desired location via said control switch and subsequently adjust said wheelchair assembly to facilitate the rotation of their self from the seated position to the kneeling prone position without the aid of another person.

US Pat. No. 10,792,204

ASSISTING DEVICE

FUJI CORPORATION, Chiryu...

1. An assisting device comprising:a movable base on which a care receiver is configured to ride;
a raising and lowering member supported on the base to be movable in an up-down direction;
a raising and lowering drive configured to drive the raising and lowering member up and down;
an oscillating member supported on the raising and lowering member, the oscillating member configured to oscillate within an oscillating range;
an oscillating drive section configured to drive the oscillating of the oscillating member;
a holding member configured to hold an upper body of the care receiver, the holding member supported on the oscillating member to be freely tiltable with respect to the oscillating member;
a first handle provided on the oscillating member; and
a second handle provided on the holding member, the second handle configured to tilt together with the holding member.

US Pat. No. 10,792,203

MECHANICAL MANIPULATOR ARM

Aqua Creek Products LLC, ...

1. A mechanical manipulator for moving a load from a first position, at a first elevation, to a second position, at a second elevation, comprising:a base having
a top, a bottom and defining a base channel between a first side plate and a second side plate,
the first side plate and the second side plate are spaced apart from, and parallel to, one another and each side plate defines plural spacedly arrayed axle holes,
a mount for securing the base to a supporting surface, and
a drive assembly communicating with a power source, to rotate the base relative to the supporting surface;
a lift frame pivotally interconnected to the base, the lift frame comprising a first load member, two support members, a fulcrum lever link and an actuator,
the first load member has a first lower end portion, a second upper end portion, and a length dimension, and the first lower end portion is pivotally carried within the base channel on an axle journaled by the two base side plates, and the second upper end is pivotally interconnected to the fulcrum lever link with an axle journaled by the fulcrum lever link, and an actuator arm yoke is carried by the first load member proximate to the first lower end portion, and
the two support members are parallel, spaced apart, and each has a first end portion, a second end portion and a length dimension therebetween,
the first lower end portion of each support member is pivotally interconnected to the base with an axle extending through one of the plural axle holes defined in the base side plate, and the second upper end portion of each support member is pivotally interconnected to the fulcrum lever link with an axle extending through an axle hole defined in the fulcrum lever link, and
the fulcrum lever link has a first lower end portion, a second upper end portion, a length dimension therebetween, and defines a U-shaped channel between two spaced apart and parallel side flanges and a transverse wall which has an interior surface within the U-shaped channel, and an exterior surface outside the U-shaped channel, and each side flange defines plural spacedly arrayed axle holes to journal axles which pivotally interconnect the second upper end portions of the two support members, and pivotally interconnect the second upper end portion of the first load member,
a bracket for engagement with a second load member is carried on the exterior facing surface of the transverse wall proximate the first lower end portion, and
the actuator has a second end portion interconnected to the fulcrum lever link at a position proximate the second upper end portion and spaced apart from the first load member interconnection and the two support members interconnection, and a first lower end portion pivotally interconnected to the actuator arm yoke, so that when actuated, the actuator moves between a first retracted position, and a second extended position; and
a second load member having a first lower end portion, a second upper end portion and a length dimension therebetween and the second load member is interconnected with the bracket carried by the fulcrum lever link, and the first lower end portion of the first load member carries a load support configured for carriage of the load between the first position, at the first elevation, and the second position at the second elevation.

US Pat. No. 10,792,202

HOSPITAL BED ASSEMBLY

1. A hospital bed assembly being configured to facilitate defecation and urination for a bed-ridden user, said assembly comprising:a bed frame being configured to be positioned on a support surface;
a mattress lying on said bed frame wherein said mattress is configured to have a user lie thereon, said mattress having an opening extending therethrough, wherein said opening is configured to be aligned with the user's buttocks when the user lies on said mattress, said mattress having a top surface, a bottom surface and a perimeter surface extending therebetween, said perimeter surface having a first lateral side, a second lateral side and a front side, said opening extending through said top surface and said bottom surface, said opening having a bounding surface, said bounding surface having a forward side, a rearward side, a first lateral side and a second lateral side, said mattress having a cut extending through said top and bottom surfaces, said cut extending between said first lateral side and said second lateral side of said mattress to define a first half being hingedly coupled to a second half of said mattress, said opening being positioned on said second half, said first half being selectively urged between an inclined position and a flat position;
a toilet unit being movably coupled to said mattress wherein said toilet unit is configured to receive feces and urine from the user, said toilet unit being configured to be fluidly coupled to a sewer thereby facilitating the feces and urine to be flushed into the sewer, said toilet unit being aligned with said opening in said mattress;
a control unit being coupled to said bed frame wherein said control unit is configured to be manipulated, said control unit being electrically coupled to said toilet unit thereby controlling operational parameters of said toilet unit;
a first roller being rotatably coupled to said mattress, said first roller being aligned with said forward side of said opening in said mattress;
a second roller being rotatably coupled to said mattress, said second roller being aligned with said rearward side of said opening in said mattress;
a sheet being rolled around said first roller and said second roller such that said sheet extends across said opening, said sheet having a plurality of removable sections; and
a motor being coupled to said first roller such that said motor selectively rolls said sheet across said opening, said motor sequentially positioning each of said removable sections over said opening, each of said panels frictionally engaging said removable section when said panels are urged into said open position such that said removable section falls into said bowl wherein removable sections are configured to facilitate the feces and urine to fall into said toilet.

US Pat. No. 10,792,201

DOCKING SYSTEMS FOR MEDICAL DEVICES AND RELATED DEVICES

Skytron, LLC, Grand Rapi...

1. A docking system for a mobile patient support apparatus comprising:a bracket adapted to be coupled to a side or end of the mobile patient support apparatus at a location above a floor;
a first arm pivotably coupled to the bracket and extending outward from the mobile patient support apparatus, wherein the first arm is configured to pivot at least thirty degrees relative to the mobile patient support apparatus about a substantially vertical pivot axis;
a second arm pivotably coupled to the bracket and extending outward from the mobile patient support apparatus, the second arm having a longer length than the first arm; and
an upright member attached to the second arm, the upright member comprising a pole bracket for releasably engaging a pole of a medical accessory device.

US Pat. No. 10,792,200

ASSISTIVE MOBILITY DEVICE

RapAdapt LLC, Webster, N...

10. A method for a person to enter a wheelchair residing on a surface, said wheel chair having a front, a rear, a first side and a second side, said wheel chair comprising:a) a vertically movable seat frame;
b) a seat, said seat having a front and a rear, said front and said rear of said seat coaligned with said front and said rear of said wheelchair, said seat pivotally coupled to said seat frame such that said front of said seat can be raised and lowered in an arcuate path;
c) a lifting platform, said lifting platform having a front and a rear, said front and said rear of said lifting platform coaligned with said front and said rear of said wheelchair, said lifting platform coupled to said seat frame;the method comprising the steps of:i) lowering said lifting platform to said surface;
ii) lowering said front of said seat;
iii) said person approaching said lifting platform
iv) said person positioning themselves on said lifting platform while facing said front side of said lifting platform; and,
v) raising said lifting platform to place said person on said seat, such that said person is facing said front of said wheelchair.

US Pat. No. 10,792,199

SUBSTRATES AND LAMINATES FOR ABSORBENT ARTICLES

1. A substrate for an absorbent article, the substrate comprising:a nonwoven material comprising:
fibers;
three-dimensional elements;
land areas comprising the fibers and positioned in areas free of the three-dimensional elements;
wherein, in the land areas, the nonwoven material has a first basis weight, according to the Micro-CT Test;
increased permeability regions comprising the fibers and positioned adjacent to at least some of the three-dimensional elements and intermediate at least some of the three-dimensional elements and at least some of land areas; and
wherein, in the increased permeability regions, the nonwoven material has a second basis weight in the range of 75% to 25% less than the first basis weight of the land areas, according to the Micro-CT Test.

US Pat. No. 10,792,198

ABSORBENT ARTICLE WITH LEG CUFFS

1. A disposable absorbent article for wearing about the lower torso of a wearer, the disposable absorbent article comprising: a first waist region, a second waist region, a crotch region disposed between the first and second waist regions; a first waist edge and a second waist edge; and a first longitudinal edge and a second longitudinal edge; wherein the disposable absorbent article comprises a chassis comprising:1.) a topsheet;
2.) a backsheet; and
3.) an absorbent core disposed between the topsheet and the backsheet;
wherein the disposable absorbent article further comprises a leg gasketing system;
wherein the leg gasketing system comprises a web of material forming an inner cuff and an outer cuff;
wherein the inner cuff comprises an inner cuff folded edge and an inner cuff material edge and the outer cuff comprises an outer cuff folded edge and an outer cuff material edge, such that the web of material is folded laterally inward to form the outer cuff folded edge and folded laterally outward to form the inner cuff folded edge;
wherein at least a portion of the web of material between the outer cuff folded edge and the outer cuff material edge is attached to the chassis in the first waist region, the second waist region and the crotch region; and at least a portion of the web of material between the inner cuff folded edge and the inner cuff material edge is attached to the web of material between the outer cuff folded edge and the outer cuff material edge in the crotch region and the first waist region; and the web of material between the inner cuff folded edge and the inner cuff material edge is unattached to the web of material between the outer cuff folded edge and the outer cuff material edge in at least a portion of the second waist region, forming a leg gasketing system pocket with an opening on an inboard longitudinal edge of the leg gasketing system pocket.

US Pat. No. 10,792,197

SURGICAL SPONGE

Multigate Medical Product...

1. A surgical sponge comprising:multiple plies of gauze having one or more open sides; and
stitches made with one or more contrasting threads and adapted to fasten or close the open sides;
wherein the contrasting threads are made of one or more non-absorbing materials, the non-absorbing materials of the contrasting threads having a soft or subdued fluoro colour that is a combination of at least fluoro-green and fluoro-yellow.

US Pat. No. 10,792,196

APPARATUS AND METHOD FOR HIGH SPEED CROSS FOLDING

Curt G. Joa, Inc., Shebo...

1. A method for folding discrete items comprising:conveying an item in a machine direction with a first conveyor, carrying said item on a first side;
carrying a second side of a leading portion of said item and rotating said leading portion in a first rotational direction with a first drum continuously rotating in said first rotational direction;
contacting a midsection of said item in a folding plane with a folding finger traveling in said machine direction, said folding finger traveling about a travel path in said folding plane;
releasing said second side of said leading portion of said item from said first drum while rotating said first drum in said first rotational direction;
carrying said first side of said leading portion of said item and rotating said leading portion in said first rotational direction with a second drum that continuously rotates in said first rotational direction;
releasing said first side of said leading portion of said item to lay said leading portion of said item atop a trailing portion of said item;
wherein said folding finger is maintained in a constant cross-machine direction orientation and in said folding plane as said folding finger travels about an entirety of said travel path.

US Pat. No. 10,792,195

POWDER SUPPLY METHOD, METHOD FOR MANUFACTURING POWDER-CONTAINING ARTICLE USING SAME, POWDER SUPPLY DEVICE, AND DEVICE FOR MANUFACTURING POWDER-CONTAINING ARTICLE USING SAME

ZUIKO CORPORATION, Osaka...

1. A powder supply method for supplying a powder to a sheet being conveyed along a conveyance path, the powder supply method comprising:dropping the powder from a storage section storing therein the powder, to distribute the powder onto a surface of the sheet through a distribution port;
moving a first opening-closing portion such that the first opening-closing portion periodically overlaps the distribution port when viewed from vertically above the distribution port, to periodically close the distribution port by the first opening-closing portion;
moving a second opening-closing portion such that the second opening-closing portion overlaps the distribution port when viewed from vertically above the distribution port, in a same cycle period as that of the first opening-closing portion and at a timing later than that of the first opening-closing portion, to periodically close the distribution port by the second opening-closing portion, and moving the second opening-closing portion such that the second opening-closing portion extends from an upstream-side edge of the first opening-closing portion lying on an upstream side of a movement direction of the first opening-closing portion toward the upstream side of the movement direction of the first opening-closing portion, during a time period during which the upstream-side edge of the first opening-closing portion overlaps the distribution port, when viewed from vertically above the distribution port; and
setting a difference between a timing at which the second opening-closing portion overlaps the distribution port when viewed from vertically above the distribution port, and a timing at which the first opening-closing portion overlaps the distribution port when viewed from vertically above the distribution port.

US Pat. No. 10,792,194

APPARATUS AND METHODS FOR SECURING ELASTIC TO A CARRIER WEB

Curt G. Joa, Inc., Shebo...

1. A laminated material comprising:a first layer of material;
a second layer of material;
a first elastic strand disposed between said first and second layers of material;
said first and second layers of material bonded together at spaced apart bond points;
said first elastic strand disposed between said first and second layers of material in a non-linear manner, said first elastic strand meandering in a first direction around said spaced apart bond points and traversing a direction line extending in a second direction orthogonal to the first direction, said first elastic strand restrained from movement in at least one of said first direction and said second direction by friction with said first and second layers;
said first elastic strand positioned between a pair of upstream bond points spaced apart in said first direction at a first upstream passage location, and positioned between a pair of downstream bond points spaced apart in said first direction at a first downstream passage location, said first upstream passage location offset from said first downstream passage location in said first direction;
a second elastic strand disposed between said first and second layers of material;
said second elastic strand positioned between a second pair of upstream bond points spaced apart in said first direction at a second upstream passage location, and positioned between a pair of downstream bond points spaced apart in said first direction at a second downstream passage location, said second upstream passage location offset from said second downstream passage location in said first direction;
said elastic strands not intersecting said spaced apart bond points;
wherein a width of said first and second elastic strands is less than a distance between said pair of upstream bond points and between said pair of downstream bond points and is less than a distance between said second pair of upstream bond points and between said second pair of downstream bond points, respectively, such that friction between said elastic strands and the first and second layers of material retain said elastic strands in place without a separate anchoring or affixing thereof to said first and second layers of material.

US Pat. No. 10,792,193

NASAL DRIP PAD

KAH MEDICAL SUPPLIES, LLC...

1. A nasal drip pad apparatus, comprising:a drip pad assembly configured to be positioned underneath a patient's nose; and
a string configured to form a pair of loops,
whereby one of the loops is configured to be placed around one of the patient's ears without extending around an entirety of the patient's head and the other one of the loops is configured to be placed around the other one of the patient's ears without extending around the entirety of the patient's head.

US Pat. No. 10,792,192

MEDICAL DRESSINGS, SYSTEMS, AND METHODS EMPLOYING SEALANTS

KCI Licensing, Inc., San...

1. A system configured to treat a wound at a tissue site, the system comprising:a pressure source configured to supply reduced pressure;
a manifold configured to be positioned in contact with the wound at the tissue site and configured to be in fluid communication with the pressure source and to provide reduced pressure to the wound at the tissue site;
a drape having a first side and a second, tissue-facing, side, and wherein the drape is configured to cover the wound at the tissue site and the manifold; and
a seal in contact with a substantial portion of the second, tissue-facing, side of the drape, wherein the seal is configured to react with a fluid to form a sealant that substantially fills one or more passages between the drape and the tissue site in response to fluid leaking through the one or more passages from outside the drape when the manifold provides reduced pressure to the wound at the tissue site.

US Pat. No. 10,792,191

FOAM WOUND INSERTS WITH REGIONS OF HIGHER AND LOWER DENSITIES, WOUND DRESSINGS, AND METHODS

KCI Licensing, Inc., San...

1. A wound insert for use with a wound dressing, the wound insert comprising:a foam having high-density regions and low-density regions, the high-density regions having a density of between 1.2 to 4 times the density of the low-density regions; and
a drape for coupling to skin of a patient adjacent a wound to which the wound dressing is applied such that the drape covers the wound insert and the wound, and forms a space between the drape and the wound.

US Pat. No. 10,792,190

HEARING PROTECTOR AND A METHOD OF MAKING A HEARING PROTECTOR

3M Innovative Properties ...

1. A hearing protector having an ear cup forming a space for a wearer's ear, the ear cup comprising:a shell having an ear facing inner side and a passageway extending through the shell between the ear facing inner side and an outer side of the shell;
a loudspeaker assembly, which fits wholly within a shell cavity, and which seals the passageway from the outer side, the loud speaker assembly comprising:
a loudspeaker module comprising first electrical contacts, wherein the loudspeaker module is positioned within the shell such that sound emitted is emitted toward an ear of a wearer of the hearing protector; and
a seal member positioned between the loudspeaker assembly and the shell; and
a fastener that retains the loudspeaker assembly in the shell, wherein the fastener comprises electronic circuitry and second electrical contacts for contacting with the loudspeaker module, and wherein the first and second electrical contacts are in releasable contact with each other.

US Pat. No. 10,792,189

LOADING TOOL FOR VENTILATION TUBE INSERTER DEVICE

Preceptis Medical, Inc., ...

1. A system configured to load a ventilation tube into an inserter device, the system comprising:a loading device including:
a main body;
at least one solid protruding member extending from the main body and terminating at a loading tip;
at least one elongated hollow body having a first end, an inner wall and an outer wall, wherein the elongated hollow body surrounds the protruding member such that at least a portion of an outer facing surface of the protruding member engages with an inner wall of the elongated hollow body; and
at least one ventilation tube that engages with the loading tip of the protruding member and is at least partially located within the elongated hollow body.

US Pat. No. 10,792,188

SYSTEMS AND METHODS FOR HIGH SPEED MODULATION OF A RESONANT SCANNER IN OPHTHALMIC LASER APPLICATIONS

AMO Development, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye, the pulsed laser beam having a pulse energy and pulse repetition rate;
a high frequency scanner configured to produce a scan line formed by the pulsed laser beam;
an XY-scan device to deflect the scan line;
a Z-scan device to modify a depth of a focus of the scan line; and
a controller configured to:
control the high frequency scanner to produce the scan line, the scan line having a scan width;
control the XY-scan device and the Z-scan device to carry out of first sweep of the scan line in a first sweep direction;
control the XY-scan device and the Z-scan device to carry out a second sweep of the scan line in a second sweep direction that is not parallel to the first sweep direction, thereby defining an overlap region, wherein at least one of the pulse energy, repetition rate, XY-scan speed, and the scan width are varied during at least one of the first sweep and second sweep so as to reduce an exposure of an ophthalmic tissue in the overlap region to multiple exposures of laser pulses configured to modify ophthalmic tissue.

US Pat. No. 10,792,187

STEERABLE LASER PROBE

KATALYST SURGICAL, LLC, ...

1. An ophthalmic laser probe comprising:a handle having a handle distal end and a handle proximal end;
an actuation structure of the handle;
an end plug having an end plug distal end and an end plug proximal end wherein the end plug distal end is disposed in the handle and wherein the end plug proximal end is not disposed in the handle;
a nosecone having a nosecone distal end and a nosecone proximal end;
a housing tube housing of the nosecone;
a first link fixed to the nosecone and the actuation structure;
a second link fixed to the nosecone and the actuation structure;
an inner hypodermic tube having an inner hypodermic tube distal end and an inner hypodermic tube proximal end wherein the inner hypodermic tube is disposed in the handle and the nosecone and wherein the inner hypodermic tube distal end is fixed in the nosecone;
a housing tube having a housing tube distal end and a housing tube proximal end wherein the housing tube proximal end is disposed in the nosecone and wherein the housing tube proximal end is fixed in the housing tube housing;
a cable having a cable distal end and a cable proximal end wherein the cable is disposed in the handle and the housing tube; and
an optic fiber having an optic fiber distal end and an optic fiber proximal end wherein the optic fiber is disposed in the handle, the inner hypodermic tube, the nosecone, and the housing tube wherein the optic fiber distal end is adjacent to the housing tube distal end and wherein a compression of the actuation structure is configured to extend the nosecone relative to the handle proximal end by actuating the first link and the second link.

US Pat. No. 10,792,186

ASSEMBLY, ESOPHAGUS CATHETER AND METHOD FOR CONTROLLING A TEMPERATURE OF AT LEAST A PART OF A PERSON, IN PARTICULAR THE BRAIN OF THE PERSON

GELANUS B.V., Hattem (NL...

1. An assembly for cooling at least a part of a person including a brain of the person, the assembly comprising:an esophagus catheter to be inserted into an esophagus of the person for temperature control, the esophagus catheter extending along a longitudinal axis, the esophagus catheter comprising a proximal heat exchanger, and a distal heat exchanger and having a length so that the proximal heat exchanger and the distal heat exchanger are both positionable in the esophagus below a level of a larynx of the person, the proximal heat exchanger being a proximal balloon having a proximal end and a distal end and the distal heat exchanger being a distal balloon having a proximal end and a distal end,
the esophagus catheter further comprising a plurality of coolant channels including at least an inlet coolant channel and an outlet coolant channel each of the inlet and outlet coolant channels are in fluid communication with the proximal heat exchanger and the distal heat exchanger, and
a coolant pump connected to at least one of the plurality of coolant channels, and
the assembly further being configured to simultaneously cause coolant flow through the proximal heat exchanger in a first direction and coolant flow through the distal heat exchanger in a second direction that is opposite the first direction, wherein coolant flow in the proximal heat exchanger is in the first direction from a proximal end to a distal end and wherein coolant flow in the distal heat exchanger is in the second direction from a distal end to a proximal end.

US Pat. No. 10,792,185

FLUID CASSETTE WITH POLYMERIC MEMBRANES AND INTEGRAL INLET AND OUTLET TUBES FOR PATIENT HEAT EXCHANGE SYSTEM

Zoll Circulation, Inc., ...

1. A device, comprising:a frame defining a periphery and an opening that is at least partially bounded by the periphery, the frame being configured for being closely received between two cold plates, the frame having at least a fluid inlet that is at least commencing in a segment of the frame and a fluid outlet at least commencing in the segment of the frame, both the fluid inlet and fluid outlet establishing respective fluid passageways through the frame into the opening, the fluid inlet and outlet being configured for fluid communication with respective fluid return and supply lines associated with a patient-engageable heat exchange member;
a membrane assembly connected to the frame and completely blocking the opening, a border portion of the membrane assembly being held between frame halves, the membrane assembly including a first membrane parallel to a second membrane with a working fluid chamber therebetween into all of which working fluid chamber working fluid can flow, the fluid inlet and fluid outlet communication with the working fluid chamber between the membranes, the working fluid chamber, into all of which working fluid can flow, being a chamber such that at least a portion of the fluid can flow inwardly from the fluid inlet to the fluid outlet with no linear or curvilinear walls impeding or redirecting fluid flow between the fluid inlet and fluid outlet, the first membrane including an inner surface inside the working fluid chamber and an outer surface outside the working fluid chamber; and
at least first and second reinforcement layers welded to the membrane assembly in the border portion through which post holes are formed, the reinforcement layers not covering a central portion of the outer surface of the first membrane,
wherein the membrane assembly defines a rectilinear border juxtaposed with the frame, the border including the membrane assembly, and wherein at least one reinforcement layer engaged with the membrane assembly does not extend radially inwardly past the border.

US Pat. No. 10,792,184

SYSTEM FOR ANAL OR STOMAL IRRIGATION AND A METHOD FOR CALIBRATING SUCH A SYSTEM

1. A system for anal or stomal irrigation, the system comprising:a reservoir adapted to contain an irrigating liquid;
a catheter comprising a catheter tip sized for insertion into one of a rectum and a stoma of a user and adapted to expel the irrigating liquid from the catheter tip;
a tubing system providing a conduit for the irrigating liquid between the reservoir and the catheter tip;
a pump operable to pump the irrigating liquid from the reservoir to the catheter tip; and
a control system including a sensor, with the sensor located in the tubing system adjacent to the catheter;
wherein the control system is configured to control operation of the pump in response to input from the sensor to have a measured pressure at the catheter tip gradually approach a predetermined threshold pressure value without exceeding the predetermined pressure value.

US Pat. No. 10,792,183

MOBILE ARM SUPPORT

Saebo, Inc., Charlotte, ...

1. A support assembly for supporting a portion of a user's body, comprising:a pivotable frame including a top elongated member, a bottom elongated member, a first side member and a second side member, the top elongated member and the bottom elongated member each having first and second ends that are pivotably connected to respective top and bottom ends of the first side member and the second side member;
a support element operatively connected to the pivotable frame, the support element being adapted to receive the portion of the user's body;
a tensioner mechanism including a tension member, the tensioner mechanism being adapted to selectively adjust an amount of force required to move the support element relative to the first side member;
an adjustment assembly configured to adjust an amount of force exerted on the tension member, the adjustment assembly including a first pulley affixed to the first end of the bottom elongated member, a second pulley affixed to the second end of the bottom elongated member, and a cable having a first end and a second end, wherein the second end of the cable is affixed to the tension member, the cable is received on both the first pulley and the second pulley, and a first portion of the cable that extends between the first pulley and the second pulley, and a second portion of the cable that extends between the second pulley and the tension member are parallel to each other and disposed entirely within the bottom elongated member; and
a support stand including a vertical support shaft, the first side member of the pivotable frame being rotatably mounted to the vertical support shaft so that a longitudinal center axis of the vertical support shaft is parallel to a longitudinal center axis of the first side member,
wherein the tension member is affixed to and disposed within bottom elongated member.

US Pat. No. 10,792,182

SURGICAL ARM POSITIONER WITH STERILE DISPOSABLE SUPPORT

Encore Medical, LP, Aust...

1. An arm retainer for supporting a patient's arm at a desired position on an articulatable support assembly for securement to an operating table, the arm retainer including:a rigid arm tray having a mounting protrusion protruding from a bottom side of said tray for connecting said rigid arm tray to an articulatable support assembly, said tray having a pair of spaced openings for securement of a disposable arm support liner to said tray;
said arm support liner comprised of a sheet of malleable material with a soft engagement surface and having a predetermined cut configuration for wrapping or forming said malleable arm support liner about a patient's arm for retention;
said arm support liner having two spaced foldout tabs aligned with said tray openings for securing said liner to said tray by folding said tabs through respective of said openings and thereafter against the bottom side of said tray.

US Pat. No. 10,792,181

ORTHOPAEDIC DEVICE AND METHOD OF USE FOR TREATING BONE FRACTURES

1. A pressure application device comprising:a sheet cover configured to extend over a portion of a patient's skin corresponding to a bone fracture under the skin, the sheet cover configured to form an enclosed volume between the portion of the patient's skin and the sheet cover, wherein the sheet cover comprises a vacuum port, the vacuum port configured to apply a vacuum to withdraw a gaseous volume from the enclosed volume;
a member, the member configured to be in the enclosed volume, the member configured to deform elastically, in response to the vacuum, in at least a direction towards the skin and apply a force to the fracture; and
a sheet, the sheet configured to extend over the portion of the patient's skin, a first surface of the sheet in contact with the patient's skin, an entire second surface of the sheet in contact with the member, the first surface of the sheet opposite to the second surface of the sheet, and wherein a first surface of the member is in contact with the sheet cover, a second surface of the member is in contact with a sheet.

US Pat. No. 10,792,180

CERVICAL COLLAR

OSSUR HF, Reykjavik (IS)...

1. A posterior portion for a cervical collar, the posterior portion comprising:a main support piece having a middle section, and first and second side sections extending from opposed sides of the middle section, the main support defining a peripheral edge about the middle section, and the first and second side sections;
a flexible edge extending from the peripheral edge of the main support, the flexible edge being formed from a material that is more flexible than a material forming the main support piece;
wherein an upper periphery of the middle section and the flexible edge form a proximal support portion anatomically shaped to correspond to and support an occipital region of a wearer;
wherein the flexible edge is integrally and contiguously formed over the peripheral edge of the main support piece and extends outwardly therefrom, the flexible edge being formed from a flexible material different from a semi-rigid material forming the main support.

US Pat. No. 10,792,179

CUSTOMIZED SPINAL BRACING TO AID IN NEUROMOTOR TRAINING

TheraTogs, Inc., Telluri...

1. A thermoformable spinal brace for customizable warm-and-form shaping to a wearer adapted for donning on the wearer along with an anterior apron assembly, comprising:(a) the thermoformable spinal brace comprising first and second integral over-the-shoulder extensions, first and second integral rib extensions, and first and second integral lower extensions, wherein each said first and second integral lower extension comprises an end-portion curved anteriorly away from a back spinal support section of the spinal brace adapted to overlap at least a portion of a pelvis area of the wearer upon donning;
(b) the anterior apron assembly comprising a central panel from which a secured end of each of a plurality of straps pivotally extends;
(c) a free-end of each of a first and second straps of said plurality of straps extending from said anterior apron is adapted for releasable attachment to said end-portion of a respective one of said first and second integral lower extensions; and
(d) a free-end of each of a third and fourth straps of said plurality of straps extending from said anterior apron is adapted for releasable attachment to said end-portion of a respective one of said first and second intergral lower extensions.

US Pat. No. 10,792,178

JOINT STABILIZING ORTHOPEDIC DEVICE

16. An orthopedic device, comprising:a torso portion, comprising:
a belt portion comprising a plurality of belt portion panels, wherein the plurality of belt portion panels are adapted to be removably coupled such that the size of the belt portion is adjustable; and
a shoulder portion comprising at least one front shoulder band portion and a back shoulder band portion, wherein the at least one front shoulder band portion is removably coupled to the belt portion, wherein the back shoulder band portion extends from the belt portion and is fixedly attached to the at least one front shoulder band portion;
an upper arm portion coupled to the shoulder portion, the upper arm portion comprising:
an inner upper arm portion;
an outer upper arm portion; and
at least one opening such that the upper arm portion can move with respect to the shoulder portion; and
a support system coupled to at least part of the shoulder portion, part of the upper arm portion, and removably coupled to part of the belt portion, wherein the support system is adapted to exert a force proximate the shoulder portion in order to promote biomechanical stability.

US Pat. No. 10,792,177

ORTHOSIS FOR CORRECTION OF A VARUS/VALGUS MALALIGNMENT

1. An orthosis for correcting a leg malalignment of a person, comprising:a support apparatus, formed in an L-shaped fashion in the frontal plane, the support apparatus including a support limb, which is configured to engage below a foot of the person, a contact limb extending vertically from the support limb, and a bracket, which is rigid under stress and is formed at a transition from the support limb to the contact limb;
a brace configured to be arranged in contact with a side of the lower leg and configured to exert a torque on the lower leg just below the knee to correct knee malalignment, wherein the brace is embodied as a resilient element, the brace is bent at an angle in a lateral direction relative to the contact limb, and the torque results from a preset pretension of the resilient element relative to the lower leg;
an attachment apparatus configured to connect an upper end of the brace to the lower leg of the person just below the knee;
a rotary joint connected between the brace and the support apparatus and configured to be arranged approximately level with an ankle joint of the person and in lateral contact on the foot to allow movement of the person's ankle joint;
wherein the preset pretension of the resilient element is configured to exert a corrective force acting only on the lower leg at a location just below the knee.

US Pat. No. 10,792,176

KNEE BRACE

Imprint Performance, LLC,...

1. A knee brace, comprising:a body configured to circumferentially extend around a knee of a subject to provide support to a patella and one or more ligaments surrounding the patella when the knee brace is worn by the subject in a standing, straight leg position, the body including
a leg member extending substantially parallel to a sagittal plane of the subject, and
a plurality of supports configured to circumferentially extend around the knee, the plurality of supports including a superior support, an inferior support, and a center support disposed between the superior support and the interior support, each of the plurality of supports connected to the leg member;
a strap including a body end and a handle end, the strap secured to the body at the body end; and
a handle secured with the handle end of the strap and configured to pull the body upwardly on the knee when the knee brace is worn by the subject.

US Pat. No. 10,792,175

ERGONOMIC PROTECTIVE SHELL DEVICE OF THE PERINEAL ORTHOSIS TYPE

Claripharm, Saint Alban ...

1. An ergonomic protective shell device of an orthosis type, the shell device comprising:a structure having an upper face and a lower surface and being comprised of a front end portion having a front first end and front second end and a rear end portion having a rear first end and a rear second end, said front second end being wider than said front first end, said rear second end being wider than said rear first end, said front second end being adjacent and made integral with said rear first end, said rear end portion being wider than said front end portion, said structure being symmetrical about a vertical longitudinal median plane,
wherein said front end portion comprises lower surface front cavity walls and upper face front cavity walls so as to form a front cavity extending between said front end portion and said rear end portion and being concave on said upper face,
wherein said rear end portion comprises lower surface rear cavity walls and upper face rear cavity walls being adjacent and made integral with said lower surface front cavity walls and said upper face front cavity walls, respectively, so as to form a rear cavity, the front cavity being made integral with the rear cavity,
wherein the front cavity is widened on said lower surface by said lower surface front cavity walls from said front first end to said front second end,
wherein the front cavity is widened on said upper face by said upper face front cavity walls from said front first end to said front second end,
wherein the rear cavity is widened on said lower surface by said lower surface rear cavity walls from said rear first end to said rear second end,
wherein the rear cavity has a first rear widening on said upper face by said upper face rear cavity walls from said rear first end toward said rear second end,
wherein the rear cavity has a first rear narrowing on said upper face by said upper face rear cavity walls from said first rear widening toward said rear second end,
wherein the rear cavity has a second rear widening on said upper face by said upper face rear cavity walls from said first rear narrowing to said rear second end, wherein said first rear narrowing on said upper face and said second rear widening on said upper face by said upper face rear cavity walls comprise support areas on both sides of the rear cavity on said upper face between said first rear end and said second rear end,
and
wherein the rear cavity has a second rear narrowing on said upper face by said upper face rear cavity walls from said first rear widening toward said rear second end, wherein the rear cavity has a second rear narrowing on said upper face by said upper face rear cavity walls from said support areas toward said rear second end on said upper face so as to be aligned to receive anatomical areas located on both sides of a perineum.

US Pat. No. 10,792,174

BARIATRIC DEVICE AND METHOD

BFKW, LLC, Ada, MI (US)

1. An intraluminal device adapted to be deployed in a recipient having a gastro-intestinal (GI) tract comprising an esophagus, a stomach with a cardiac portion and an esophageal gastric (EG) junction having a sphincter between the esophagus and the cardiac portion of the stomach, the intraluminal device comprising:a body having a wall defining a lumen, said wall having at least one selected from (i) an esophageal wall portion configured to generally conform to the shape and size of the abdominal portion of the esophagus (ii) an EG wall portion that is sized to generally conform to the size and shape of the EG junction and (iii) a cardiac wall portion that is sized to generally conform to the size and shape of the cardiac portion of the stomach;
said wall adapted to exert force in the absence of food to a portion of the GI tract of the recipient to thereby influence a neurohormonal feedback mechanism of the recipient to cause at least partial satiety by augmenting fullness caused by food and simulating fullness in the absence of food; and
a fixation system at an outer surface of said wall that is adapted to resist distal migration of said body, said fixation system comprising a plurality of anchors comprising at least one chosen from distally directed appendages, distally directed barbs and distally directed hooks.

US Pat. No. 10,792,173

STENT DELIVERY SYSTEM AND METHOD

DePuy Synthes Products, I...

1. A stent delivery system, comprising:a catheter including a lumen extending therethrough;
a stent disposed within the lumen of the catheter, the stent including a lumen extending therethrough;
a core wire disposed within the lumen of the stent; and
a capture member having a proximal end attached at a fixed position to the core wire, and the capture member being disposed entirely within the lumen of the catheter, being biased radially outward, and grasping a proximal portion of the stent within the lumen of the catheter and thereby pressing the proximal portion of the stent radially inward toward the core wire;
wherein the stent, the core wire, and the capture member are configured to be collectively moved proximally and distally within the lumen of the catheter with the capture member pressing the proximal portion of the stent radially inward toward the core wire; and
wherein, with the capture member pressing the proximal portion of the stent radially inward toward the core wire, a distal end of the stent is freely expandable radially outward relative to the core wire and the capture member and configured to automatically expand radially outward outside of the lumen of the catheter in response to the distal end of the stent advancing distally out of a distal opening of the lumen of the catheter.

US Pat. No. 10,792,172

HEART VALVE REPLACEMENT DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

Aortic Innovations, LLC, ...

1. A heart valve assembly comprising:an outer frame, wherein the outer frame is formed from a metallic material and defines a gridded configuration;
an inner frame that houses a prosthetic heart valve, wherein the inner frame is a graft covering extending around the prosthetic heart valve for providing sealing to the heart valve,
wherein the graft covering is one of polyester, PTFE, ePTFE, or a polymer;
wherein the outer frame is secured to the graft covering,
wherein the outer frame is secured to the graft covering by a plurality of stitches,
a sealing material positioned externally to the outer frame for providing sealing between the outer frame and a patient's anatomical wall to prevent paravalvular leaks, wherein the sealing material includes a plurality of radially extending fibers that extend outwardly of the outer frame.

US Pat. No. 10,792,171

PROSTHETIC ADAPTER MODULE

Fillauer Europe AB, Soll...

1. A prosthetic adapter module configured to be attached, by a predetermined number of screws, to a socket member of a prosthetic sleeve, into which sleeve an amputation stump of a prosthesis user is to be inserted, the adapter module comprising:a disc-shaped connection washer having a central axis, and
a module body provided with a washer space structured to provide room for the disc-shaped connection washer,
the washer space having an extension to provide for movement of the disc-shaped connection washer within a plane essentially perpendicular to a longitudinal axis of said prosthetic sleeve prior to the disc-shaped connection washer being fixated in a determined position,
the disc-shaped connection washer having an interior surface defining a through hole for receiving a washer attachment screw such that the screw essentially extends along said longitudinal axis,
the through hole having a central axis centered with respect to the interior surface of the connection washer that defines the through hole,
the central axis of the through hole being positioned off-center in relation to the central axis of the disc-shaped connection washer in order to maximize lateral movement of the disc-shaped connection washer in all directions within the plane,
the module body being provided with a first side structured to face the socket member, and a second side at the other side of the module body, and
the first side being provided with a first side opening to the washer space having a size such that the disc-shaped connection washer may enter the washer space via the first side opening.

US Pat. No. 10,792,170

SYSTEMS AND METHODS FOR PROSTHETIC DEVICE CONTROL

BOARD OF REGENTS, THE UNI...

1. A method for controlling a prosthetic device, the method comprising:measuring a plurality of variables with one or more sensors, wherein:
the one or more sensors are operatively coupled to a controller; and
the controller is configured to control the prosthetic device comprising a plurality of joint elements;
determining a value of a monotonic phasing variable based on measurements of the plurality of variables; and
adjusting a joint element of the plurality of joint elements in response to the value of the monotonic phasing variable by enforcing a unified virtual constraint that controls an entire gait cycle of the prosthetic device, wherein the monotonic phasing variable is monotonic throughout the entire gait cycle.

US Pat. No. 10,792,169

HYBRID TERRAIN-ADAPTIVE LOWER-EXTREMITY SYSTEMS

Otto Bock Healthcare LP, ...

1. An apparatus comprising:a foot member;
a lower leg member worn by a wearer;
an ankle joint for connecting the foot member to the lower leg member;
an inertial measurement unit comprising a gyroscope for measuring an angular rate and an accelerometer for measuring acceleration, the inertial measurement unit disposed on the lower leg member to collocate a measurement of angular rate and acceleration for each of at least two axes of the lower leg member in a coordinate system; and
a hardware controller configured to:
track a trajectory of a point on the lower leg member over underlying terrain by the inertial measurement unit, the trajectory being tracked within a cycle defined by the wearer taking a single step with the lower extremity apparatus;
determine that the tracked trajectory matches an activity type selected from among a group of predefined activity types, or that the tracked trajectory does not match any of the predefined activity types, and
when the tracked trajectory matches the activity type, determining a mode of control based on the predefined activity type, and controlling the lower extremity apparatus according to the determined mode, or when the tracked trajectory does not match any predefined activity type, performing a predefined unclassified control operation.

US Pat. No. 10,792,168

IMPLANT INSERTION INSTRUMENT

Alphatec Spine, Inc., Ca...

15. An implant insertion instrument configured to engage an implant during the performance of a surgical procedure, the implant insertion instrument comprising:a handle configured to rotate in a first direction;
a sleeve fixedly mounted to a distal end of the handle;
an implant rod disposed within the sleeve, the implant rod having a gripper disposed on a distal end of the implant rod, the gripper having a first prong spaced apart from a second prong, wherein the proximal ends of the first prong and the second prong are integrally formed to the rod;
a drive mechanism configured to translate a rotation of the handle in the first direction into an axial displacement of the implant rod so as to pull the first and second prongs within the sleeve towards the handle closing the first prong against the second prong so as to secure the implant between the first and second prongs; and
a locking mechanism configured to allow rotation of the handle in the first direction while resisting rotation of the handle in a direction opposite the first direction so as to fix the handle within the sleeve.

US Pat. No. 10,792,167

SURGICAL IMPACTOR/EXTRACTOR ASSEMBLY AND METHOD OF USE

ARTHREX, INC., Naples, F...

1. A method, comprising:linearly moving an actuator of a surgical impactor/extractor assembly in a first direction;
moving each of a first arm and a second arm of the surgical impactor/extractor assembly from a collapsed position to an expanded position in response to linearly moving the actuator in the first direction;
positioning the surgical impactor/extractor assembly relative to a prosthetic device;
moving the actuator in a second direction that is opposite to the first direction;
collapsing the first arm and the second arm against the prosthetic device in response to moving the actuator in the second direction;
tightening or loosening an adjustment block of the surgical impactor/extractor assembly relative to the prosthetic device; and
inserting the prosthetic device into a joint or removing the prosthetic device from the joint,
wherein movement of the first arm is guided via a linkage assembly within a first slot formed in a housing of the surgical impactor/extractor assembly, and movement of the second arm is guided via the linkage assembly within a second slot formed in the housing.

US Pat. No. 10,792,166

SELF-PIVOTING SPINAL IMPLANT AND ASSOCIATED INSTRUMENTATION

DePuy Synthes Products, I...

1. A method of spinal surgery, comprising:grasping a post of an intervertebral implant with a grasper at a distal end of an instrument, wherein the post is disposed within a slot at an engagement end of the intervertebral implant;
advancing the intervertebral implant toward an intervertebral disc space of a patient while maintaining the intervertebral implant in an initial articulation position, in which a surface of the grasper abuts a surface of the intervertebral implant in a manner preventing articulation of the intervertebral implant beyond a range of articulation relative to the instrument;
inserting the intervertebral implant into the intervertebral disc space; and
during the inserting step, rotating the post with respect to the grasper, thereby rotating the intervertebral implant with respect to the instrument from the initial articulation position to a final articulation position, in which another surface of the grasper abuts another surface of the intervertebral implant in a manner preventing articulation of the intervertebral implant beyond the range of articulation, wherein the surface and the another surface of the intervertebral implant are angularly offset from each other.

US Pat. No. 10,792,165

EXPANDABLE INTERVERTEBRAL IMPLANT FOR TREATMENT OF SCOLIOSIS

1. An expandable intervertebral implant, comprising:a support component, including:
a first cross-member;
a second cross-member; and,
one or more vertical members connecting the first and second cross-members,
wherein the second cross-member is displaceable relative to the first cross-member;
an inferior component, including:
a first proximate end connected to the first cross-member;
a first distal end;
a first top surface; and,
a first bottom surface;
a superior component, including:
a second proximate end connected to the second cross-member;
a second distal end;
a second top surface; and,
a second bottom surface; and,
a wedging component operatively arranged to be:
passed completely through the first and second cross-members; and,
slid along the first top surface and the second bottom surface and expand the expandable intervertebral implant.

US Pat. No. 10,792,164

INTERSOMATIC IMPLANTS

Stryker European Operatio...

1. A spinal implant for re-establishing a curvature of a spine comprising:a hollow body having a proximal end, a distal end, and first and second lateral walls extending from said proximal end to said distal end, said first and second lateral walls having a concave-shaped cross-section with concave interior surfaces, the interior surfaces having non-threaded portions for defining an at least partially cylindrical internal space between said lateral walls, said hollow body having upper and lower faces with bone-contacting surfaces that are inclined relative to one another in two directions, the bone-contacting surfaces being arranged to contact and space apart adjacent bones of respective vertebral bodies, wherein a distance between at least some of the bone-contacting surfaces of the upper and lower faces continuously decreases from the first lateral side wall to the second lateral side wall of said hollow body, and from the proximal end to the distal end of the body; and
an anchoring member having bone anchoring projections, said anchoring member being insertable into said hollow body,
wherein the bone anchoring projections are a self-tapping screw thread having a radial cross-section that transforms from a substantially triangular radial cross-section to a substantially square radial cross-section starting from a distal end of said thread.

US Pat. No. 10,792,163

SPINAL IMPLANT

1. A spinal implant comprising:an implant unit configured to be disposed between a first vertebra and a second vertebra adjacent to the first vertebra; and
a buffer unit configured to be disposed in the implant unit to disperse or absorb a pressure, an impact, or a load, which is applied from the first vertebra and the second vertebra,
wherein the implant unit includes:
a main body configured to be inserted between the first vertebra and the second vertebra from a back portion of a recipient;
a screw thread arranged along an outer circumferential surface of the main body in one direction; and
an operation space defined in the main body from a rear end of the main body to a front side of the main body, the buffer unit being configured to be disposed in the operation space,
wherein the screw thread includes a larger diameter part disposed between the front end and the rear end of the main body and having a greatest outer diameter,
wherein, in a virtual line passing through a center of the main body in a longitudinal direction of the main body, a first distance of the virtual line from the larger diameter part to the rear end of the main body is equal to or greater than a second distance of the virtual line from the front end of the main body to the larger diameter part,
wherein a deformation notch is formed on the implant unit to be penetrated to allow the operation space to communicate with an outside of the implant unit and extends from the rear end of the main body to a front end of the deformation notch in the longitudinal direction of the main body, the deformation notch being gradually narrowed from the rear end of the main body to the front end of the deformation notch,
wherein the front end of the deformation notch is located between the front end of the main body and the larger diameter part, and
wherein a third distance of the virtual line from the front end of the deformation notch to the large diameter part is ? to ½ of the second distance of the virtual line.

US Pat. No. 10,792,162

SHOULDER ARTHROPLASTY TRIAL SENSORS

Zimmer, Inc., Warsaw, IN...

1. A shoulder arthroplasty trial assembly for a human shoulder comprising:a first implant securable to a first bone; and
a second implant securable to a second bone, the second implant comprising:
a body;
a stem extending from the body, the stem insertable into the second bone;
a cup coupled to the body opposite the stem;
an articulation component disposed entirely within the cup to create a concave articulation surface opposite the stem, the articulation component articulable with the first implant;
a biasing element connected to the body and the articulation component, the biasing element configured to bias the articulation component to a position at least partially extended from the cup; and
a sensor connected to the articulation component and configured to monitor a condition of the second implant and produce a sensor signal as a function of the condition that is indicative of stability of the shoulder,
wherein the biasing element is disposed within the cup and biases the articulation component outwardly from the cup.

US Pat. No. 10,792,161

ADJUSTABLE MODULAR SPACER DEVICE FOR THE ARTICULATION OF THE KNEE

1. A method of implanting a knee spacer device at a joint area between a tibia and a femur of a patient, to replace an infected joint prosthesis and preserve size or spaces of the joint area before implanting a new prosthesis, the method comprising:providing a spacer device comprising:
a tibial unit configured to be fixed to the tibia of the patient and having an upper first joint surface that is essentially curved and delimits an essentially concave sliding seat, and
a femoral unit configured to be fixed to the femur of the patient and having a lower first joint face that is essentially convex and configured to be positioned in the concave sliding seat to slidingly engage the first upper joint surface, thereby enabling a mutual angular displacement between the tibial unit and the femoral unit,
wherein at least one of the tibial unit or the femoral unit comprises a first component fixable to the tibia or respectively to the femur and distal from the first joint surface or respectively from the first joint face, and a second component adjustably fixable to the first component in a plurality of operational positions and defining the first joint surface or respectively the first joint face;
implanting the tibial unit into the tibia and the femoral unit into the femur, wherein the first component, engaged to the second component, of the at least one of the tibial unit or the femoral unit are connected to one another by fixing means in a first position or rest condition, and wherein the fixing means initially connect without fixing the first component to the second component;
adjusting a distance between the tibia and the femur so as to reduce the joint, thereby bringing the tibial unit and the femoral unit in interference and causing a self-centering or an automatic adjustment of a relative position of the second component with respect to the first component in one of the plurality of operational positions, whereby the self-centering or the automatic adjustment of the relative position between the tibial unit and the femoral unit is provided; and
bringing the fixing means in a second position or condition, in which the fixing means fix the second component to the first component in the one of the plurality of operational positions.

US Pat. No. 10,792,160

ELBOW PROSTHESIS

Encore Medical, L.P., Au...

1. A joint prosthesis device, comprising:a first stem structure comprising a first end configured to be implanted into a first bone of a patient and an opposite second end terminating in a pair of furcations; and
a first bearing component removably coupled to the second end of the first stem structure, the first bearing component comprising:
a first condyle portion that is removably attached to a first of the pair of furcations, the first condyle portion being at least partially spherically shaped and including a first pin aperture,
a second condyle portion that is removably attached to a second of the pair of furcations and separate from the first condyle portion, the second condyle portion being at least partially spherically shaped and including a second pin aperture, and
a pin extending between the first condyle portion and the second condyle portion, a first end of the pin inserted into the first pin aperture and a second end of the pin inserted into the second pin aperture.

US Pat. No. 10,792,159

OSTEOARTHRITIS TREATMENT AND DEVICE

ZIMMER KNEE CREATIONS, IN...

1. A method of delivering an implant to a targeted treatment area in a subchondral region of a proximal tibia of a knee joint for treating a bone marrow lesion identified in the subchondral region, the method comprising:identifying a bone marrow lesion (BML) in a subchondral region of a proximal tibia of a knee joint through use of magnetic resonance imaging (MRI) of the knee joint, the subchondral region of the proximal tibia occurring under an articular surface of the proximal tibia;
creating, in the proximal tibia that contains the bone marrow lesion in the subchondral region, a subchondral delivery path to a targeted treatment area, wherein the targeted treatment area includes an area in the subchondral region where the bone marrow lesion was identified and/or an area in the subchondral region that is up to 1 cm from where the bone marrow lesion was identified, and wherein said creating is conducted without creating a void in the targeted treatment area that opens into the overlying articular cartilage of the proximal tibia so as to preserve an existing condition of the overlying articular cartilage of the proximal tibia;
delivering a solid structural subchondral implant to said targeted treatment area in the subchondral region of the proximal tibia, wherein the solid structural subchondral implant is resorbable, and wherein the solid structural subchondral implant is delivered to the targeted treatment area along said subchondral delivery path that is formed in the proximal tibia; and
delivering an injectable fluid material to the targeted treatment area via the subchondral delivery path, wherein the injectable fluid material includes an osteogenic, osteoconductive and/or osteoinductive material,
wherein said solid structural subchondral implant comprises a proximal face adapted to face the knee joint and a distal face adapted to face away from the knee joint, said solid structural subchondral implant defined by a three-dimensional planar shape having a thickness and a maximum dimension of 5 mm or less, the three-dimensional planar shape being longer in a first dimension and a second dimension than in a third dimension, the third dimension being the thickness of the three-dimensional planar shape, the third dimension being less than or equal to 50% of the first dimension and the second dimension of the three-dimensional planar shape.

US Pat. No. 10,792,158

SPACER DEVICE FOR TREATING A JOINY OF THE HUMAN BODY

1. A spacer device, implantable in a human body for treatment of an infected bone seat or joint seat or for a two-step treatment of infections of a joint prosthesis, comprising:a joint component;
a stem component; and
connection elements,
wherein said joint component is adapted to be inserted in an articular zone of a patient,
wherein said stem component is adapted to be implanted in a bone or in a residual bone bed of a preceding joint prosthesis,
wherein said joint component has an external surface,
wherein said stem component comprises a first portion having a substantially elongated shape,
wherein at least part of an external surface of the first portion of said stem component and at least part of an external surface of said joint component are adapted to define a contact surface with bone tissue or are adapted to be coupled with the bone tissue,
wherein said connection elements are placed between said joint component and said stem component and are configured to enable adjusting a distance therebetweeen,
wherein said contact surface present in said joint component and in said stem component comprises a plurality of recesses for housing at least one filling material comprising at least one pharmaceutical or medical substance,
wherein said plurality of recesses is placed substantially along the contact surface, and
wherein each recess of said plurality of recesses has a planar surface extension and a depth,
wherein said planar surface extension is greater than the depth, each recess having a perimeter wall, which is respectively extended towards an interior of said joint component or of said stem component, and a base wall, which forms a base of each recess and determines the planar surface extension or an opening of each recess.

US Pat. No. 10,792,157

FUSED FEMORAL STEM SYSTEM

BEIJING AK MEDICAL CO., L...

1. A fused femoral stem system, comprising:a curved handle;
a fixing mechanism; and
a femoral head prosthesis;
wherein the fixing mechanism comprises a lag screw and a fused screw sleeve;
wherein the fused screw sleeve is configured to penetrate a large trochanter, and the lag screw is configured to be connected and locked with a connecting mechanism so as to counteract a downward bending moment generated when the femoral head bears the weight load after surgery, and wherein the lag screw is configured to be connected and locked with the connecting mechanism after penetrating through the fused screw sleeve;
wherein one end of the curved handle is provided with a conical connector, the conical connector is cooperatively connected with a conical connecting hole of the femoral head prosthesis, and the other end of the curved handle is inserted from the osteotomy surface of the femoral neck and configured to stretch to the position of a medullary cavity below a small trochanter, and the curved short handle is connected and fixed to the large trochanter through the fixing mechanism;
wherein the fused screw sleeve comprises a hollow tubular body configured to penetrate from the outside of the large trochanter, wherein an outer surface of the hollow tubular body comprises a metal porous structure, and surrounds an inner surface thereof comprising a solid metal sleeve structure, wherein the fused screw sleeve further comprises an annular structure located at the outside of the bone cortex of the large trochanter.

US Pat. No. 10,792,156

METHODS AND DEVICES FOR DETERMINING A POSITION OF ACETABULAR AND FEMORAL COMPONENTS DURING A SURGICAL HIP REPLACEMENT PROCEDURE

1. A method of assessing a position of an acetabular component in an acetabulum during a surgical procedure, the method comprising:inserting a dummy implant into a femoral canal of a femur;
inserting a head of a measuring instrument into the acetabular component that is positioned in the acetabulum;
simultaneously engaging the head of the measuring instrument with the acetabular component and a second section of the measuring instrument with the dummy implant; and
while the measuring instrument is engaged with both the acetabular component and the dummy implant, visually determining a position of a line between two visually-different sections of the head relative to an open end of the acetabular component with the first and second sections having different colors.

US Pat. No. 10,792,155

THREADED INSERT FOR IMPLANT

Howmedica Osteonics Corp....

1. An implant comprising:a body having a hole extending therethrough along a first longitudinal axis, the hole having a distal portion with a distal diameter and a proximal portion with a proximal diameter, the distal diameter being greater than the proximal diameter; and
an insert configured to be housed within the hole of the body, the insert having a proximal face and a distal face with an external wall extending therebetween, an aperture extending from the proximal face to the distal face along a second longitudinal axis, the aperture having internal threads configured to threadingly engage a fastener,
wherein at least a first dimension of the external wall measured normal to the hole is greater than the proximal diameter and substantially the same as the distal diameter such that the insert when housed with the hole of the body is located in the distal portion.

US Pat. No. 10,792,154

LIMB SPARING IN MAMMALS USING PATIENT-SPECIFIC ENDOPROSTHESES AND CUTTING GUIDES

SOCOVAR, L.P., Montreal ...

1. A limb sparring system for replacing a portion of a radius, the radius being adjacent to an ulna, the system comprising:a cutting guide including a cut guiding portion for guiding a saw when making a predetermined cut in the radius to excise the portion of the radius, an opposed ulnar mounting portion mountable to the ulna, and a linking portion extending therebetween; and
an endoprosthesis configured for replacing the portion of the radius after the portion of the radius has been excised;
wherein, when the cutting guide is operatively mounted to the radius and ulna, the cut guiding portion and the ulnar mounting portion engage respectively the radius and the ulna in a predetermined spatial relationship relative thereto; and
wherein the cutting guide is delimited by a cutting guide peripheral surface defining a bone facing portion which faces the radius and ulna when the cutting guide is operatively mounted thereto, the bone facing portion being contoured to match a shape of the radius and the ulna.

US Pat. No. 10,792,153

IMPLANTABLE CARDIAC VALVE IMPROVEMENT DEVICE, SYSTEM AND PROCEDURE

Syntach AG, (CH)

1. An implantable medical device including: an anchor unit configured to be permanently anchored at a cardiac valve of a patient, at least one locking unit, and a plurality of coupling units of fixed or adjustable length for connecting said anchor unit to said at least one locking unit; each coupling unit having a first end portion and a second end portion, said first end portion connectable to said anchor unit, and said second end portion including said at least one locking unit, wherein the first end portion of each of the coupling units pivotably connects the coupling unit to different positions at the anchor unit, and the second end portion of the coupling units connected to each other by the at least one the locking unit.

US Pat. No. 10,792,152

CLOSED BAND FOR PERCUTANEOUS ANNULOPLASTY

Valtech Cardio, Ltd., Or...

1. A method comprising:during a percutaneous transcatheter procedure, placing an annuloplasty device entirely around an annulus of a mitral valve of a subject in a closed loop, the annuloplasty device comprising a flexible sleeve;
fastening the flexible sleeve to the annulus by coupling a plurality of tissue anchors to a posterior portion of the annulus, without coupling any tissue anchors to any anterior portion of the annulus between left and right fibrous trigones of the annulus; and
after (a) placing the annuloplasty device entirely around the annulus in the closed loop and (b) fastening the flexible sleeve to the annulus, longitudinally contracting a longitudinal portion of the flexible sleeve, wherein the longitudinal portion has a length less than a length of the entire flexible sleeve.

US Pat. No. 10,792,151

DELIVERY SYSTEMS FOR DELIVERING PROSTHETIC HEART VALVE DEVICES AND ASSOCIATED METHODS

TWELVE, INC., Redwood Ci...

1. A system for delivering a prosthetic heart valve device into a heart of a patient, the system comprising:an elongated catheter body including a distal portion and proximal portion;
a delivery capsule carried by the elongated catheter body on the distal portion, the delivery capsule including a platform and a housing having a sidewall and a proximal rim, the housing being configured to slide along the platform from a containment configuration to a deployment configuration, and the platform and the sidewall defining a chamber for retaining a prosthetic heart valve device in the containment configuration; and
an expandable atraumatic member associated with the delivery capsule, the atraumatic member having an opening, an atraumatic surface, and a peripheral portion, wherein the atraumatic member is configured to be in (a) a compacted configuration in which the atraumatic member is within the chamber in the containment configuration and (b) an expanded configuration in which the peripheral portion extends laterally outward over the proximal rim of the housing in the deployment configuration,
wherein, when the expandable atraumatic member is in the expanded configuration:
the atraumatic surface and the peripheral portion of the expandable atraumatic member are located proximal to the proximal rim of the delivery capsule with the atraumatic surface being proximal to the peripheral portion,
the peripheral portion of the expandable atraumatic member covers the proximal rim around an outer perimeter of the delivery capsule in the deployment configuration when the delivery capsule is withdrawn in a proximal direction from tissue of the patient, and
the expandable atraumatic member is tapered in a distal direction.

US Pat. No. 10,792,150

EXPANDABLE SHEATH FOR INTRODUCING AN ENDOVASCULAR DELIVERY DEVICE INTO A BODY

Edwards Lifesciences Corp...

1. An expandable introducer sheath comprising:a polymeric tubular layer comprising a circumferentially discontinuous distal end region and a circumferentially continuous central region positioned proximally to the distal end region, the distal end region of the tubular layer comprising a first longitudinally extending side, a second longitudinally extending side overlapping the first longitudinally extending side, and a body portion extending circumferentially therebetween, the central region comprising a first longitudinally extending fold, a second longitudinally extending fold, an overlapping portion extending between the first and second longitudinally extending folds, and a body portion extending circumferentially therebetween; and
an elastic outer cover extending at least partially over the distal end region and the central region of the polymeric tubular layer.

US Pat. No. 10,792,149

EXPANDABLE STENT AND METHODS OF CRIMPING AND EXPANDING SUCH STENT

Strait Access Technologie...

1. An expandable stent comprising a cylindrical wall made up of:lattice members connected to each other;
at least one first arm that comprises:
a first non-linear member that is connected at each of its axial ends to a lattice member at respective first junctions; and
a second non-linear member connected at each axial end to:
(i) a lattice member; or
(ii) the first non-linear member of the first arm,
which connections restrain the axial ends of the first arm's second non-linear member from protruding from the surrounding stent wall during:
radial expansion of the stent, and consequent protrusion of the first arm radially outwards from the surrounding stent wall; and
at least one bridge member extending between the first non-linear member and the second non-linear member,
at least one second arm that comprises:
a first non-linear member that is connected at each of its axial ends to a lattice member; and
a second non-linear member connected at each axial end to a lattice member, which connections restrain the axial ends of the second arm's second non-linear member from protruding from the surrounding stent wall during: radial expansion of the stent, and consequent protrusion of the second arm radially outwards from the surrounding stent wall; and
at least one bridge member extending between the first non-linear member and the second non-linear member,
characterised in that:
the second non-linear member of the first arm is generally U-shaped, extending from its axial ends towards: (i) a first axial end of the stent; and (ii) towards the bridge of the first arm;
the second non-linear member of the second arm is generally U-shaped, extending from its axial ends towards: (i) a first axial end of the stent; and (ii) towards the bridge of the second arm;
the first arm is disposed at a second axial end of the stent, and the second arm is:
(i) axially spaced from the first arm towards the first axial end of the stent; and (ii) axially aligned with the first arm;
the first non-linear member of each of the first and second arms is connected to lattice members at the first non-linear member's axial ends only;
the second non-linear member of the first arm is connected to: (i) lattice members;
or (ii) the first non-linear member of the first arm, at the first arm's second non-linear member's axial ends only; and
the second non-linear member of the second arm is connected to lattice members at the second arm's second non-linear member's axial ends only,such that, upon radial expansion of the stent from a radially crimped condition under the influence of an external force, tension in: (i) the bridge of the first arm; and (ii) the bridge member of the second arm, causes the second non-linear members of both the first and second arms to protrude from the first and second arms' second non-linear members' connected axial ends radially outwards from the surrounding stent wall, respectively.

US Pat. No. 10,792,148

INTRAOCULAR LENS WITH SINGLE LENS TELESCOPE INTEGRATED IN THE OPTICAL PART THEREOF

Carl Zeiss Meditec AG, J...

1. An intraocular lens comprising:an optical part including an optically imaging element and a convex-concave telescope; and
a haptic part connected to the optical part;
the convex-concave telescope being formed in one piece, being integrated into the optically imaging element, having a convexly-curved front side and a concavely-curved rear side, being arranged as a single lens, and being a solid cavity-free arrangement;
the convexly-curved front side of the convex-concave telescope having a convex curvature for facing towards incident light entering the intraocular lens;
the concavely-curved rear side of the convex-concave telescope having a concave curvature for facing away from the incident light;
the convexly-curved front side of the convex-concave telescope having a first radius;
the concavely-curved rear side of the convex-concave telescope having a second radius; and
the first radius being larger than the second radius,
wherein the optical part of the intraocular lens defines an optical main axis,
wherein the optically imaging element radially adjoins the convex-concave telescope, and
wherein the convex-concave telescope extends on both sides of the intraocular lens beyond the optically imaging element when viewed in a direction of the optical main axis of the optical part.

US Pat. No. 10,792,147

OPHTHALMIC LENS AND METHOD OF MANUFACTURING OPHTHALMIC LENS

Nikon Corporation, Tokyo...

1. An ophthalmic lens to be attached in or near an eyeball, comprising:a first region that is near an optical axis;
a second region that is farther from the optical axis than the first region; and
a third region that is farther from the optical axis than the second region, wherein:
in a state where the ophthalmic lens is attached to the eyeball, light rays passing through the first region, the second region, and the third region form an image on a retina;
the first region applies a first phase difference of 3 rad or more of a third phase difference to the light ray passing through the first region with respect to the light ray passing through the third region;
the second region applies a second phase difference to the light ray passing through the second region, the second phase difference continuously connecting phase differences of the light ray passing through the first region and the light ray passing through the third region, and continuously changing in accordance with a distance from the optical axis; and
the third region applies the third phase difference to the light ray passing through the third region, the third phase difference varying in accordance with the distance from the optical axis around a reference value, wherein a variation amplitude of the third phase difference is not less than 0.1 rad and less than the first phase difference.

US Pat. No. 10,792,146

HOLDING AND ADJUSTMENT MECHANISM FOR SURGICAL TETHER

Kyon AG, Zurich (CH)

1. A holding mechanism for surgical tethers, the holding mechanism comprising:a tether;
an orifice sheath comprising a longitudinal passage defined in a conical-shaped body, the conical-shaped body having a wide end and a tapered narrow end, the orifice sheath accommodating a section of the tether, the passage terminating in first and second orifices through which first and second portions of the tether protrude, with the first orifice located at the wide end of the orifice sheath; and
a restraint element with a soft elongated structure independent from the tether, the soft elongated structure of the restraint element being conformable to a surface of the first orifice;
wherein another section of the tether forms a bight projecting from the first orifice of the orifice sheath, and wherein the soft elongated structure of the restraint element, independent from the tether, is positioned under the bight of the tether and over the first orifice located at the wide end of the conical-shaped body of the orifice sheath such that the soft elongated structure of the restraint element contacts the wide end of the conical-shaped body defining the first orifice and conforms to the surface of the first orifice without being received within the longitudinal passage defined in the conical shaped body of the orifice sheath.

US Pat. No. 10,792,145

TWO STAGE CELLULARIZATION STRATEGY FOR THE FABRICATION OF BIOARTIFICIAL HEARTS

UNIVERSITY OF HOUSTON SYS...

1. A method of fabricating a bioartificial heart comprising:fabricating at least one artificial heart muscle patch, wherein the fabricating comprises:
obtaining and/or isolating neonatal cardiomyocytes from a subject,
preparing a fibrin gel scaffold,
seeding the cells in the prepared scaffold, and
culturing the cells within the scaffold;
decellularizing a heart to obtain a scaffold;
wrapping the at least one artificial heart muscle patch to surround the scaffold;
suturing the at least one artificial heart muscle patch surrounding the scaffold to form a construct; and
culturing the construct.

US Pat. No. 10,792,144

LONGITUDINALLY AND RADIALLY FLEXIBLE ANASTOMOSIS STENT

1. A anastomosis stent, comprising:an elongated body of a tubular configuration and having a length dimension extending in an axial direction of said elongated body and a diameter dimension extending in a radial direction of said elongated body being in a transverse relationship to said axial direction of said elongated body;
said elongated body being formed by a multiplicity of rings stacked adjacent to one another in a direction parallel to said length dimension of said elongated body, each of said rings being formed by a single strand of wire bent in a repetitive pattern of sine waves, said alternating peaks and valleys of said sine waves of said single strand of wire of a given ring being reversed in adjacent ones of said rings extending along opposite upper and lower sides of said given ring;
said multiplicity of rings being fused to one another at locations on selected pairs of adjacent peaks and valleys of said sine waves in said single strand of wire of each of said rings, said fused locations being displaced circumferentially from each other so as to provide flexibility of said rings in said radial direction relative to said axial direction of said elongated body; and
said elongated body comprising
a main portion comprising a majority of said multiplicity of rings each being a continuous strand of said single wire moveable between collapsed and expanded conditions along said length dimensions of said sine waves of said continuous strands of said single wires,
an end portion comprising a minority of said multiplicity of rings at least some being continuous strands and others being discontinuous strands such that said minority of said multiplicity of rings are moveable between parallel and flared relationships to said length dimension of said elongated body, and
a safety mark in the form of a band of an adhesive composition encompassing said elongated body at a juncture of said main and end portions together, said safety mark being used to guide accurate implanting of said elongated body.

US Pat. No. 10,792,143

SNAP LOCK PACKAGING

Howmedica Osteonics Corp....

1. A package comprising:a tray including a recessed portion with a bottom surface, the bottom surface including a first engagement feature; and
an insert sized to fit within the recessed portion of the tray and having a second engagement feature, the insert adapted to support disposal of an implant therein such that the implant is substantially encapsulated by the insert,
wherein the insert is releasably secured to the tray when the first engagement feature is engaged with the second engagement feature,
wherein the insert is moveable while releasably secured to the tray such that the implant, when disposed in the insert, is inaccessible when the insert is in a first position and is accessible when the insert is in a second position,
wherein the implant remains sterile when the implant is inaccessible, and
wherein a quantity of engagement features engaged with one another in the first position is different than in the second position.

US Pat. No. 10,792,142

IMPLANTABLE AREAL DEVICE FOR SUPPORTING TISSUE

1. An implantable areal device for supporting defective musculofascial tissue mechanically and by regeneration of muscle and fascial tissue; wherein said implantable areal device is formed by a plurality of thread sections; wherein said thread sections define a plurality of void spaces; wherein at least one of said void spaces is more than one-hundred square millimeters in area; wherein said plurality of thread sections are singular monofilament, and wherein said implantable areal device comprises less than 121 thread intersections per one-hundred square centimeters, thread intersection being defined as crossing of two of said thread sections.

US Pat. No. 10,792,141

SOFT TISSUE IMPLANT AND METHOD OF USING SAME

BLOCKHEAD OF CHICAGO, LLC...

1. A flexible polymer soft tissue temporal implant having a shell with a symmetric C-shaped overall configuration, a grooved exterior surface with spaced support structures having varying heights and thicknesses, where each support structure projects at an angle transverse to the shell, the projecting support structures are formed as peaks and troughs and are arced in their overall configuration, the shell of the flexible polymer soft tissue temporal implant has a curved configuration in cross section, and the flexible polymer soft tissue temporal implant is sufficiently flexible that the shell of the flexible polymer soft tissue temporal implant may be bent so that an edge of the grooved exterior surface touches along an opposite edge of the grooved exterior surface.

US Pat. No. 10,792,140

PARTIAL CUFF

1. An apparatus comprising:a curved shape-memory material extending from a first end to a second end, the first end and the second end curving toward one another and defining a gap between the respective first and second ends when the curved shape-memory material is in a relaxed state; and
a surface material extending along an inner curved surface of the shape-memory material and configured and arranged to facilitate tissue in-growth, the shape-memory material being configured and arranged with the surface material to:
in response to the shape-memory material being expanded and subsequently released onto an outer surface of tubular tissue having a radius of curvature that corresponds to a radius of curvature of the shape-memory material in the relaxed state, engage the surface material onto the outer surface of the tubular tissue with the inner curved surface extending in a tubular shape along a length of the outer surface of the tubular tissue; and
via the engaging, restrict fluid flow through the tubular tissue along the length of the inner curved surface by applying pressure for restricting expansion of the tubular tissue, via engagement of the surface material along the length of the outer surface of the tubular tissue.

US Pat. No. 10,792,139

TREATMENT OF KNEE DISORDERS IN THE DOG

Kyon AG, Zurich (CH)

1. A method of treating a disordered dog stifle, the method comprising surgically transecting the tendon of the popliteal muscle just caudally to a lateral collateral ligament or at an origin of the tendon of the popliteal muscle on a distal lateral side of the femoral condyle, the origin of the tendon of the popliteal muscle located between the lateral collateral ligament and a tendon of a long digital extensor muscle, and securing a cut end of the popliteal muscle to another bone structure.

US Pat. No. 10,792,138

CLEANING DEVICE

Shanghai Shift Electrics ...

1. A personal cleaning care appliance comprising a handle with a handle housing and a cleaning device converting a reciprocating motion into a rotary motion,the cleaning device comprising:
a cleaning device housing detachably connected to the handle housing; a bracket for supporting the cleaning device, detachably fixed to the cleaning device housing; a cleaning element carrier and cleaning elements distributed on the cleaning element carrier, wherein one end of the cleaning element carrier opposite to an end of the cleaning element carrier having the cleaning elements distributed is coupled with the cleaning device housing with a seal;
a cleaning device transducer;
a passive assembly which is located above a drive coil in the handle housing and comprises a permanent magnet carrier and a plurality of permanent magnets, wherein the permanent magnet carrier is fixed to an end of the cleaning device transducer opposite to a cleaning element carrier coupling shaft, the plurality of permanent magnets are fixed to the permanent magnet carrier;
wherein the cleaning device transducer comprises a transducer bracket, at least two transducer elastic elements, transducer elastic element retainers and the cleaning element carrier coupling shaft, the cleaning element carrier coupling shaft is tightly inserted into the cleaning element carrier so that the cleaning device transducer is fixedly coupled with the cleaning element carrier; one end of each transducer elastic element is fixedly coupled with a corresponding transducer elastic element retainer, and the other end of each transducer elastic element is fixedly coupled with a transmission arm of the transducer bracket coupling elastic element;
wherein the cleaning device having a natural vibration frequency fnatural is constituted utilizing a bending strain of an elastic material, so that the natural frequency fnatural of the cleaning device is in a range of 100 Hz to 400 Hz, and a relationship between the natural frequency fnatural and a frequency f0 of an electromagnetic force generated by the drive coil in the handle meets 0.85f0 wherein the plurality of permanent magnets are configured in such a way that, when an alternating current flows through the drive coil fixed in the handle housing, the drive coil and the plurality of permanent magnets interact to generate an electromagnetic force, such that a resultant force of the electromagnetic forces generated between the drive coil and the plurality of permanent magnets and acting on the passive assembly is close to zero, i.e., the forces acting on the passive assembly is balanced, and at the same time, the passive assembly is subjected to a torque rotating in a clockwise or counterclockwise direction formed by the electromagnetic forces, wherein a maximum projection area formed by projecting a minimum plane of a same horizontal section containing all the permanent magnets of the passive assembly on a plane perpendicular to a rotation axis of the cleaning device transducer is less than 60 mm×60 mm.

US Pat. No. 10,792,137

DEVICE WITH CONTROLLABLE SWITCH TERMINAL VOLTAGE

Shanghai Shift Electrics ...

1. A device with controllable switch terminal voltage, comprising:a switch signal unit for outputting a corresponding switch signal according to a state of a switch, the switch signal unit comprises a first transistor, the switch is coupled between the first transistor and a power supply for controlling close-open of a current path between the first transistor and the power supply;
a biasing unit coupled to the switch signal unit for outputting a bias voltage to the switch signal unit, the biasing unit comprises a bottom bias part and an upper bias part on top of the bottom bias part;
wherein when the switch is open and a conductive liquid and/or a stream of a conductive liquid exists inside the switch, the biasing unit cooperates with the switch signal unit so as to control a terminal voltage of the switch and a current flowing through the switch;
wherein the first transistor is a bipolar transistor, one terminal of the switch is coupled to an emitter of the first transistor, wherein the switch is coupled in series with a PN junction between the emitter and a base of the first transistor so as to form a first series circuit, the first series circuit is coupled in parallel with the upper bias part of the biasing unit or the switch is coupled in series with a NP junction between the emitter and base of the first transistor so as to form a second series circuit, the second series circuit is coupled in parallel with the bottom bias part of the biasing unit.

US Pat. No. 10,792,136

TOOTHBRUSH

QUIP NYC INC., Brooklyn,...

1. A toothbrush, comprising:a replaceable head portion including a sensor activation portion disposed proximate to a bottom of the head portion, the sensor activation portion including an external surface and an internal surface;
a removable and replaceable handle portion;
a sealed, impermeable capsule including a motor assembly, the capsule being configured to be received within the handle portion, the motor assembly including at least one sensor in a plurality of sensors detachably coupled to the internal surface of the sensor activation portion, the at least one sensor is activated by transmitting energy from the external surface through the internal surface to the at least one sensor, wherein operation of the toothbrush is controlled using the at least one sensor and at least another sensor in the plurality of sensors; and
a locking mechanism for securely attaching the head portion to the handle portion for brushing, the locking mechanism including
a receiving opening disposed within a housing of the replaceable head portion, wherein at least one recess is disposed on an interior wall of the receiving opening; and
a protruding portion disposed at a top of the handle portion, wherein the protruding portion including at least one post;
the receiving portion receives the protruding portion to detachably snap-fit the replaceable head portion to the handle portion by using the at least one post to engage the at least one recess.

US Pat. No. 10,792,135

DENTAL TOOL SUPPORT

1. A tool holder apparatus comprising:a bendable portion including a first end and a second end opposite the first end, the bendable portion configured to maintain a position when bent;
a quick release tool holder member located at the first end;
a quick release tool grip located at the second end, the quick release grip including at least one anchoring member, the anchoring member includes a passageway through which a portion of the second end of the bendable portion extends and displaceable members surrounding the passageway are configured to move away from the passageway or move toward the passageway in response to positional change of the portion of the second end within the passageway.

US Pat. No. 10,792,134

METHOD AND DEVICE FOR MANUFACTURING AND CONTROLLING THE CONFORMITY OF A DENTAL PROSTHESIS FROM PARAMETERS OBTAINED WITH A SHADE SELECTING DEVICE

TCM, (FR)

1. A method for manufacturing and controlling the conformity of a dental prosthesis from parameters obtained intra-orally with a first shade selecting device characterized in that it comprises the following steps:a) selecting the shade of a client tooth to be replaced or restored by the practitioner using the first shade selecting device belonging to the practitioner with local storage of first data,
b) transmitting the first data to a computer station of the practitioner which is equipped with software for the visualization of the measurement data and with software for the entry of the client's contact information and specific data, both software programs being advantageously combined,
c) transmitting the first data to a computer station of a dental technician,
d) manufacturing the prosthesis according to the first data received from the practitioner,
e) capturing second data of the prosthesis manufactured by the dental technician using a second shade selecting device belonging to said dental technician that is identical to and calibrated in the same way as the first shade selecting device of the practitioner,
f) transmitting the second data of the manufactured prosthesis to the practitioner for approval, and
g) sending of the compliant prosthesis by the dental technician to the practitioner after said practitioner's approval
wherein each of the first and second shade selecting devices comprises a measuring head including at least a tip, one light source and image acquisition means, and a data processing unit,
wherein each of the data processing units allows determining the color of the tooth by areas to achieve a mapping of variations in different characteristics of the tooth, and
wherein each of the tips includes a chromatic reference surface which allows the first and second shade selecting devices to perform an automatic self-calibration, the chromatic reference surface being identical in both first and second shade selecting devices.

US Pat. No. 10,792,133

3D SCANNER AND ARTIFICIAL OBJECT PROCESSING DEVICE USING THE SAME

DDS COMPANY, Seoul (KR)

1. A 3D scanner comprising:a pattern generator irradiating a light pattern to a subject; and
an image receiver receiving an omni-directional image of the subject to which the light pattern is irradiated,
wherein the image receiver includes a first lens, the first lens having a specific angle of view according to a refractive index, the first lens having at least one refractive surface and at least one reflective coating surface.

US Pat. No. 10,792,132

IMPLANT PLACEMENT KEY

PALTOP ADVANCED DENTAL SO...

1. A method for inserting a dental implant into tissue of a subject via an oral surgical guide that is customized to oral anatomy of the subject, the method comprising:inserting a guide-sleeve into the customized oral surgical guide, the guide-sleeve having a non-circular lumen at a proximal end thereof;
placing the customized oral surgical guide over an implant site;
coupling the dental implant to an implant delivery device; and
subsequently, advancing the dental implant into the tissue by rotating the implant delivery device about a longitudinal axis of the implant delivery device until a guide-sleeve connection element, disposed on a proximal portion of the implant delivery device lockingly engages the guide-sleeve, such that the guide-sleeve connection element at least partially enters the non-circular lumen of the guide-sleeve, the guide-sleeve connection element having the same shape as the non-circular lumen such that any further advancement and rotation of the implant with respect to the tissue is prevented,
wherein rotating the implant delivery device comprises coupling a rotator element to an implant-delivery-device/rotator-element interface disposed on the proximal portion of the implant delivery device, and rotating the implant-delivery-device/rotator-element interface about the longitudinal axis of the implant delivery device, and
wherein the implant delivery device comprises an elastic element which is (a) in a deformed state and (b) configured to advance the guide-sleeve connection element towards the guide-sleeve by applying a force in a distal direction to the guide-sleeve connection element as the implant-delivery-device/rotator-element interface is rotated about the longitudinal axis of the implant delivery device.

US Pat. No. 10,792,131

DENTURE REFERENCE AND REGISTRATION SYSTEM

Global Dental Science, LL...

1. An improved denture system comprising:a support bar comprising:
at least one reference post;
at least one implant interface;
a one piece integrally-formed denture base comprising:
an oversize cutout comprising a unitary channel extending an entire length of said support bar and wherein said support bar may be placed;
simulated dental structures or a voids for placing them;
at least one corresponding cavity wherein said at least one reference post may be inserted, wherein said corresponding cavity extends farther into said denture base than said oversize cutout;
wherein the at least one reference post is not vertically aligned with the at least one implant interface; and
wherein said support bar is maintained in substantially fixed communication with said denture base to secure said denture base.

US Pat. No. 10,792,130

SECONDARY PART, SET, DENTAL IMPLANT, GINGIVA FORMER, IMPRESSION PART, DENTAL IMPLANT SYSTEM, AND METHOD FOR PRODUCING AN IMPLANT

Camlog Biotechnologies AG...

1. A dental implant for insertion into a jawbone, for use with a secondary part for attachment to a dental implant and suitable for receiving an auxiliary part or a tertiary part, wherein the secondary part comprises:a secondary-part body with a recess on an inside,
a secondary-part screw being able to be accommodated within the recess,
wherein the secondary part has a screwing-in mechanism in the form of a contour for receiving a screwing-in tool, for screwing in the dental implant into a jawbone, if said dental implant is connected to the secondary part,
wherein at least the secondary-part screw has a self-retaining structure for engaging with the screwing-in tool, and the self-retaining structure is formed by a resilient head, and
wherein an outside of the secondary-part body is formed in such way that during intended use of the secondary part, the outside of the secondary part conically tapers inwardly, at least in part, at a coronal end region on which the auxiliary part or the tertiary part can be received, such that the secondary-part body has a coronal cone extending partially in the circumferential direction, wherein the angle between the longitudinal axis of the secondary-part body and the conical portion is between 5° and 15°,
for use with a set comprising the dental implant and the secondary part,
the dental implant comprising an external thread with a thread root for anchoring the dental implant in the jawbone,
wherein the thread root has at least one elevation extending from the thread root and being located between two adjacent thread flanks, and wherein at least two cutting grooves are arranged in the area of the external thread, wherein the cutting grooves are formed as twisted cutting grooves, and in that at least one short cutting groove and at least one long cutting groove is provided, wherein the short cutting groove is shorter than the long cutting groove, and
wherein the short cutting groove extends from the apical end and runs across the apical area, starting from the apical end.

US Pat. No. 10,792,129

SOFT TISSUE IN-GROWTH OF POROUS, THREE-DIMENSIONALLY PRINTED, TRANSCUTANEOUS IMPLANTS OF VARYING MATERIAL AND PORE GEOMETRY

University of Maine Syste...

1. An implant comprisinga biocompatible substrate including a first layer and a second layer, wherein said first layer comprises a plurality of pores, and said second layer comprises a plurality of pores, wherein the pores of said first layer have geometries that are different than the pores of said second layer, and wherein said implant is configured as a transcutaneous implant to remain in the skin and to facilitate skin tissue and/or subcutaneous tissue ingrowth.

US Pat. No. 10,792,128

ORTHODONTIC SETTLING RETAINER

Richter Orthodontics, P.C...

1. A dental settling retainer, comprising:a retainer body having a plurality of dental impressions including a labial surface opposite a lingual surface to receive teeth in a dental arch, said retainer body impressions formed of one material; and
a pair of passthrough openings on opposite sides in said retainer body, wherein each of said pair of passthrough openings being adapted to correspondingly allow passage of a plurality of molars, premolars or canines of said teeth in said dental arch through said retainer body, each of said pair of passthrough openings defined by a lingual passthrough periphery configured to provide a gap between said lingual passthrough periphery and a gum line of a lingual surface of said plurality of molars, premolars or canines of said teeth in said dental arch and said gap configured to prohibit contact of said lingual passthrough periphery from contacting a lingual surface of said plurality of molars, premolars or canines.