US Pat. No. 10,478,637

SYSTEM AND METHOD FOR LIMITING CHEMOTHERAPY-INDUCED ALOPECIA

Hair Science Systems LLC,...

1. A cold cap for use in limiting chemotherapy-induced hair loss in a patient, said cap adapted for connecting to a chiller unit for circulating chilled fluid through the cap and receiving pressurized air for supplying compression to the scalp of a patient, wherein said cap comprises:at least three layers of fluid impermeable material which are sealingly attached around their periphery so as to form a cooling fluid chamber configured to cool the scalp when chilled fluid is circulated through the cooling fluid chamber, and an air chamber configured to apply compression to the scalp when pressurized air is supplied to the air chamber;
fluid inlet and outlet conduits in fluid communication with said cooling fluid chamber and configured for detachable attachment to a fluid outlet and a fluid inlet of the chiller unit;
air inlet tubing in communication with said air chamber;
a first internal seal that seals said at least three layers to one another, said first internal seal spaced inwardly of the sealed periphery of said at least three layers so as to provide additional support and define a serpentine flow pattern within said cooling fluid chamber, thereby defining a flow pattern by which chilled fluid can be circulated over and about the patient's head so as to provide generally uniform cooling of the patient's scalp; and
second and third internal seals located along opposite sides of said cap, said second and third internal seals extending inwardly from the sealed periphery of said at least three layers, such that each of said second and third internal seals together with an adjacent portion of said sealed periphery define regions within said cap that are not in fluid communication with said cooling fluid chamber;wherein said cap is adapted to be worn by the patient such that the cap extends in surrounding relationship to and conforming to the patient's scalp, with said regions not in fluid communication with said cooling fluid chamber extending over the patient's ears such that cooling is not applied to the patient's ears during use.

US Pat. No. 10,478,636

LIGHT THERAPY DEVICE FOR RHINITIS OR TYMPANITIS TREATMENT

EVORAY CO. LTD., Cheongj...

1. A light therapy device, comprising:a housing including a hanging part configured to lie over a user's nose, a pair of accommodating parts connected to both sides of the hanging part, respectively and accommodating a light source, and a pair of bridge parts connected to the pair of accommodating parts, respectively and provided to lie over a user's ear, each of the accommodating parts including an end thereof, the ends of the accommodating parts being positioned under the hanging parts and being opposite to each other;
wherein the light source comprises a pair of light sources positioned inside the pair of accommodating parts respectively and emitting light for treatment;
a pair of rhinitis treatment optical guides detachably coupled with the ends of the accommodating parts, having a shape protruding from the ends of the accommodating parts so that the rhinitis treatment optical guides continue to be inserted in user's nostrils when the hanging part lies over the user's nose after inserting the rhinitis treatment optical guides into the user's nostrils and guiding the light emitted from the pair of light sources to an outside of the housing;
a battery positioned inside the housing and configured to supply power to the light sources; and
a control substrate positioned inside the housing and configured to include a switch for controlling the power to be supplied to the light sources.

US Pat. No. 10,478,635

PHOTOBIOMODULATION THERAPY SYSTEMS AND METHODS

Joovv, Inc., San Clement...

1. A light therapy system, comprising:a first light therapy device comprising a first housing, a first plurality of lights arranged and configured to emit at least one of red light and near infrared light, and a first communication module communicatively coupled to the first plurality of lights and located within the first housing;
a second light therapy device comprising a second housing, a second plurality of lights arranged and configured to emit at least one of red light and near infrared light, and a second communication module communicatively coupled to the second plurality of lights and located within the second housing, wherein the first communication module is configured to communicate directly with the second communication module;
a first control panel coupled to the first housing and communicatively coupled to the first communication module, the first control panel comprising a first plurality of input buttons and a first pair of indication lights communicatively coupled to the first plurality of input buttons, the first pair of indication lights arranged and configured to indicate whether a portion of red lights of the first plurality of lights is emitting red light and whether a portion of near infrared lights of the first plurality of lights is emitting near infrared light; and
a second control panel coupled to the second housing and communicatively coupled to the second communication module, the second control panel comprising a second plurality of input buttons and a second pair of indication lights communicatively coupled to the second plurality of input buttons, the second pair of indication lights arranged and configured to indicate whether a portion of red lights of the second plurality of lights is emitting red light and whether a portion of near infrared lights of the second plurality of lights is emitting near infrared light.

US Pat. No. 10,478,630

ANALYZE OPTION BUTTON FOR AN AUTOMATED EXTERNAL DEFIBRILLATOR (AED) WITH DUAL ECG ANALYSIS ALGORITHMS

KONINKLIJKE PHILIPS N.V.,...

1. A method for truncating CPR output instructions from a defibrillator in favor of controlling an electrotherapy output from the defibrillator during the application of CPR, comprising the steps of:providing a defibrillator having an ECG signal input, a user interface including an input button and a visual display, a shock delivery circuit, and a first ECG analysis algorithm that is operable to determine a shockable cardiac rhythm from the ECG signal in the presence of a CPR-related signal noise artifact from the input;
analyzing the ECG signal with the first ECG analysis algorithm during a first period;
sensing an activation of the input button during the analyzing step; and
if activation of the input button is sensed, setting an operating state of the defibrillator to one that is responsive to both of the sensed activation of the input button and the analyzed ECG signal.

US Pat. No. 10,478,627

IMPLANTABLE LEADLESS PACEMAKER WITH ATRIAL-VENTRICULAR SYNCHRONIZED PACING

1. An implantable leadless pacemaker (iLP) for a human or animal heart, the iLP comprising:a housing;
at least two electrode poles for picking up electrical potentials and/or delivering electrical stimulation;
a stimulation control unit in connection with the electrode poles;
a sensing unit in connection with at least one electrode pole; and
a signal processing and signal evaluation unit in connection with the sensing unit;
wherein the iLP is configured to be anchored within a ventricle,
wherein the sensing unit is configured to sense electrical potentials via the at least two electrode poles,
wherein the sensing unit is configured to sense a first signal associated with an activity of the ventricle, the first signal comprising a QRS-complex,
wherein the stimulation control unit is configured to deliver electrical stimulation in the ventricle via the at least two electrode poles,
wherein the sensing unit is configured to sense a second signal,
wherein the sensing unit comprises an impedance sensor which is configured to acquire impedance signals representing cardiac activity,
wherein the second signal is an impedance signal representing contraction of an atrium,
wherein the sensing unit is configured to sense the QRS-complex, wherein upon sensing the QRS-complex, the signal processing and signal evaluation unit is configured to begin a timer in which no atrial activity should be detected, and wherein at the end of the timer, the signal processing and signal evaluation unit is configured to enter a detection phase in which the contraction of the atrium is expected.

US Pat. No. 10,478,623

SYSTEM AND METHOD FOR NON-INVASIVELY CONTROLLING AUTONOMIC NERVE ACTIVITY

Indiana University Resear...

13. A system for controlling nerve activity in a subject, the system comprising:a plurality of electrodes configured for placement at locations proximate to nerves innervating a subject's skin;
a signal generator configured to generate electrical stimulations; and
a processor configured to direct the signal generator to deliver, using the plurality of electrodes, an electrical stimulation configured to control a sympathetic nerve activity by remodeling at least one neural structure in the subject, the electrical stimulation delivered to the neural structure via the nerves innervating the subject's skin.

US Pat. No. 10,478,622

SYNERGISTIC MUSCLE ACTIVATION DEVICE

Sage Products, LLC, Cary...

1. A method of delivering more than one type of energy waveform to a patient, comprisingpositioning an electrode on a patient's skin, the electrode adapted to be in communication with an energy delivery control unit;
combining more than one type of electrical energy waveform into a multiplexed signal, each type of electrical energy waveform having a repeating frequency; and
delivering the multiplexed signal to a muscle through the skin of the patient from the electrode.

US Pat. No. 10,478,621

RETRACTABLE LEAD SYSTEMS

General Electric Company,...

1. A retractable lead system comprising:a cup disposed proximate a vacuum end of the retractable lead system, the cup defining a cavity and a contact reception seat, the contact reception seat defining a spherical portion having a contact reception spherical radius;
a spherical contact disposed within the contact reception seat, the spherical contact defining a contact spherical radius that corresponds to the contact reception spherical radius, the spherical contact configured to be electrically coupled to an interior lead disposed within a vacuum environment; and
a plunger comprising an ambient contact and a retractable contact disposed on opposite ends of the plunger, the ambient contact disposed proximate an ambient end of the retractable lead system, the plunger configured to be actuated between an open position at which the retractable contact is retracted from the spherical contact and a closed position at which the retractable contact is coupled with the spherical contact.

US Pat. No. 10,478,620

INTERVENTIONAL MEDICAL SYSTEMS, DEVICES, AND METHODS OF USE

Medtronic, Inc., Minneap...

1. A method for deploying an implantable medical device to a target implant site located in a chamber of a patient's heart, the device comprising a hermetically sealed housing containing an electronic controller, a pacing electrode electrically coupled to the controller and mounted in proximity to a distal end of the housing, and a plurality of elastically deformable fixation fingers spaced apart from one another around a perimeter of the distal end of the housing an elastically deformable between an extended condition, a relaxed condition, and a compressed condition, wherein each fixation finger includes a first segment and a second segment, each first segment extending from a fixed end of the corresponding finger to the corresponding second segment, and each second segment extending from the corresponding first segment to a free end of the corresponding finger, and wherein, when the plurality of fingers are in the relaxed condition, each free end is closer to the housing than when the plurality of fingers are in the extended condition and, when the plurality of fingers are in the compressed condition, each free end is closer to the housing than when the plurality of fingers are in the relaxed condition, the method comprising:loading an entirety of the medical device into a distal-most portion of a deployment tube of a delivery tool such that a proximal end of the device abuts a distal end of an inner member of the tool, and such that each fixation finger is deformed into the extended position with each finger extending distally from the distal end of the housing, the distal-most portion of the tool holding the fixation fingers in the extended position, and the inner member of the tool extending within a lumen of the deployment tube;
navigating the delivery tool with the device loaded therein through a venous system of the patient to locate the distal-most portion of the tool in the chamber of the heart;
retracting the deployment tube of the delivery tool with respect to the inner member and the loaded device to expose the fixation fingers out through a distal opening of the lumen of the deployment tube, the distal opening terminating the distal-most portion of the tube, and the exposed fixation fingers being released to the relaxed condition with each finger extending in a proximal direction and outward from the housing; and
advancing the delivery tool toward the target implant site, after retracting the deployment tube, and thereby wedging the exposed fixation fingers into the compressed condition and between opposing tissue surfaces of the implant site, the wedged fingers being compressed to hold the pacing electrode of the device in intimate tissue contact by a spring force that passively fixates the implantable medical device to tissue at the implant site without penetrating the tissue at the implant site.

US Pat. No. 10,478,615

IMPLANTABLE MEDICAL SYSTEM

Medtronic Bakken Research...

1. An implantable medical system, comprising:an implantable device comprising a power source and electrical components, the power source and electrical components configured to generate electrical pulses; and
a probe having a distal end and a proximal end, the distal end comprising one or more electrodes configured to be in electrical contact with a target tissue, the probe comprising:
first wires connecting the one or more electrodes to the implantable device, the first wires configured to conduct, from the implantable device to the one or more electrodes and into the target tissue, the electrical pulses generated by the electrical components of the implantable device, wherein the first wires extend from the distal end of the probe to the proximal end of the probe;
at least one capacitor configured to perform one or more functions of the implantable device; and
second wires connecting the at least one capacitor to the electrical components in the implantable device such that the at least one capacitor forms a part of the electrical components of the implantable device, wherein the second wires are different than the first wires.

US Pat. No. 10,478,609

BLOOD CONTROL CATHETER VALVE EMPLOYING ACTUATOR WITH FLEXIBLE RETENTION ARMS

Becton, Dickinson and Com...

1. A catheter assembly comprising:a catheter adapter;
a septum configured to be retained within the catheter adapter; and
an actuator configured to pass partially through the septum to open the septum, wherein the actuator comprises a plurality of proximally-facing flexible retention arms that are biased in an outward position, the actuator further comprising a plurality of channels disposed in an outer surface of the actuator, wherein the flexible retention arms fold inwardly into the plurality of channels and are flush with the outer surface as the actuator moves distally through the septum and return to the outward position after the flexible retention arms have moved distally through the septum thereby retaining the actuator within the septum.

US Pat. No. 10,478,608

VALVE DEVICE WITH ELASTICALLY PRETENSIONED CLOSURE ELEMENT FOR A MEDICAL SYSTEM

Fresenius Kabi Deutschlan...

15. A method for operating a valve device for a medical system, the method comprising the steps of:providing the valve device comprising a valve housing, an inlet port arranged on the valve housing, an outlet port arranged on the valve housing, a flow duct extending through the valve housing connecting the inlet port and the outlet port to allow for a fluid flow through the valve housing between the inlet port and the outlet port, and a closure element arranged on the valve housing for selectively opening and closing the flow duct,
operating the valve device by a user directly or indirectly engaging a head portion of the closure element from an exterior of the housing and manually displacing the closure element by pulling the closure element along a displacement direction relative to the valve housing from a closed position in which the flow duct is closed for preventing the fluid flow from the inlet port to the outlet port to an opened position in which the flow duct is opened for allowing the fluid flow from the inlet port to the outlet port, wherein the closure element is elastically pretensioned to move axially into the closed position by an elastic planar section of the closure element that is clamped within the valve housing.

US Pat. No. 10,478,601

APPLICATOR

KAKEN PHARMACEUTICAL CO.,...

1. An applicator, comprising a solution container having a neck portion, which is provided with a circular opening, and a columnar brush member obtained by impregnating a bundle of synthetic fibers with an adhesive and then grinding the bundle of synthetic fibers, whereinthe columnar brush member is disposed at the opening of the solution container, and
a tip portion of the columnar brush member is a brush and is disposed outside the solution container, and an end face of the columnar brush member is put in the solution container,
a tip portion of the columnar brush member has a fan shape extending in a perpendicular lateral direction against a vertical longitudinal direction, and
a thickness of the fan-shaped tip portion of the columnar brush member decreases in a perpendicular lengthwise direction against the vertical longitudinal direction toward the tip portion of the columnar brush member, wherein
the perpendicular lateral direction and the perpendicular lengthwise direction are directions orthogonal to each other on a plane perpendicular to the vertical longitudinal direction, and
a capillary is formed as a gap for supplying a solution between the synthetic fibers inside the columnar brush member from an end face of the columnar brush member to the tip portion opposite to the end face of the columnar brush member by capillarity thereof,
wherein the columnar brush member is formed by bundling synthetic fibers 7 to 50 ?m in diameter so that the density ranges from 0.15 to 0.65, wherein the density is the rate of synthetic fibers per sectional area to an adhesive gluing the same, with a cross section cut perpendicular to the vertical longitudinal direction of the columnar brush member,
a bottomed tubular holder having a tubular body and a bottom portion is provided between the solution container and the columnar brush member,
the bottomed tubular holder comprises a supporting member inside said holder, the bottomed tubular holder is inserted into the opening of the solution container,
the bottom portion of the bottomed tubular holder has at least one pore and the solution enters the bottomed tubular holder via said at least one pore, and
the columnar brush member is inserted inside of the tubular body of the bottomed tubular holder, wherein
the applicator is retained with the columnar brush member facing downward, and a solution placed inside the solution container enters the bottomed tubular holder via the at least one pore provided at the bottom portion of the bottomed tubular holder to reach an end face of the columnar brush member, and
the solution in the solution container is an athlete's foot medicine or a liquid tinea unguium medicine.

US Pat. No. 10,478,599

COMPRESSION TORQUE DEVICE

Vascugenix LLC, Little R...

1. A compression torque device, consisting of:a housing, comprising
a body,
a handle,
a leading portion, and
an actuator opening, in the body,
a first opening on the leading portion,
a second opening on the handle,
an actuator, operably coupled to the housing at the actuator opening,
a flexible clamping member,
optionally, an introducer, coupled to the housing, and
a linear lumen, passing through the housing and contiguous with the actuator opening,
wherein the actuator and the flexible clamping member are monolithic and formed of the same material,
the housing is monolithic, and
the actuator pivots between a first position and a second position about a hinge point between ends of the actuator, such that the flexible clamping member extends further into the lumen when the actuator is in the first position and extends less into the lumen when the actuator is in the second position.

US Pat. No. 10,478,598

CATHETER SYSTEM

Covidien LP, Mansfield, ...

1. A catheter system comprising:an elongate catheter defining a longitudinal axis, a first lumen, a second lumen, and a third lumen;
a guidewire configured to be positioned within the second lumen, wherein the guidewire and the elongate catheter are movable relative to each other; and
a fastening structure configured to be positioned within the second lumen or the third lumen, wherein the fastening structure is configured to selectively engage the guidewire to secure the guidewire with respect to the elongate catheter such that movement of the guidewire causes deflection of the elongate catheter with respect to the longitudinal axis.

US Pat. No. 10,478,595

INFINITELY ROTATABLE TOOL WITH FINITE ROTATING DRIVE SHAFTS

Auris Health, Inc., Redw...

1. A catheter rotation drive apparatus, comprising:a first pair of input drives coupled to one another via a first belt, the first pair of input drives comprising a first drive and a first engagement shaft, the first drive coupled to a first drive pulley;
a second pair of input drives coupled to one another via a second belt, the second pair of input drives comprising a second drive and a second engagement shaft, the second drive coupled to a second drive pulley;
wherein each of the first and second drives are engageable to an output shaft;
wherein when the first drive is engaged to the output shaft and rotated, the output shaft rotates in an output rotation direction,
wherein when the second drive is engaged to the output shaft and rotated, the output shaft rotates in the output rotation direction,
wherein when the first engagement shaft of the first pair of input drives is engaged, the second engagement shaft of the second pair of input drives is disengaged, such that when the first drive pulley is rotated in its drive direction, the output shaft is caused to rotate via the first belt in the output rotational direction.

US Pat. No. 10,478,589

WEARABLE DEVICE FOR SLEEP ASSISTANCE

KONINKLIJKE PHILIPS N.V.,...

1. A wearable device for sleep assistance, comprising:at least one sensor to detect one or several vital signs of a user of the wearable device;
a memory to store a set of sleep aid techniques,each sleep aid technique includes instructions facilitating the user to fall asleep and is associated with a doze-off time estimated for the sleep aid technique to affect the user following the instructions;an interface to receive a selection of a sleep aid technique from the set of sleep aid techniques and to render the instructions of the selected sleep aid technique to the user; and
a processor to update the doze-off time based on the vital signs of the user, to determine, based on the updated doze-off time, a schedule for executing at least one predetermined action, and to execute the predetermined action according to the schedule.

US Pat. No. 10,478,586

ARTIFICIAL RESPIRATION SYSTEM AND METHOD HAVING AUTOMATIC MASK DETECTION

Daniel A. McCarthy, Tyle...

1. A ventilator system, comprising:a set of two or more ventilator masks, wherein each of at least two of the ventilator masks is configured in a size that will fit upon a different range of sizes of human faces than at least one other ventilator mask in the set of two or more ventilator masks, wherein each of the at least two ventilator masks comprises a gas flow restrictor that is different from a gas flow restrictor of the other ventilator masks of the at least two ventilator masks; and
a ventilator supply system, comprising:
an air/oxygen source;
a connector configured to couple with each of the at least two ventilator masks;
an air/oxygen supply system comprising a detection system capable of determining a pressure created by the application of air/oxygen to a mask coupled to the ventilator supply system;
a proportional valve coupled to the detection system and the air/oxygen source, wherein the proportional valve controls the flow rate of air/oxygen from the air/oxygen source to the detection system; and
a controller coupled to the detection system, wherein the controller determines, during use, which mask, among the two or more ventilator masks, is coupled to the air/oxygen supply system based on the pressure detected by the detection system.

US Pat. No. 10,478,582

ADAPTOR FOR BREATHING TUBE AND METHOD

Barthel LLC, Wauwatosa, ...

1. A device for delivering a medicament into a breathing tube from a counter metered-dose canister (CoMDC) comprising a valve stem and a counter window, the device excluding a boot-type inhaler comprising:a body defining a chamber adapted to receive an inverted CoMDC, the body comprising:
a floor;
an arcuate sidewall defining a chamber for receiving the CoMDC, a portion of the sidewall comprising opposing exposed edges defining a U-shaped profile free of sidewall;
a vertical conduit extending from the chamber through the floor and into a breathing tube connector located below the floor, the vertical conduit having:
an upper portion located in the body chamber,
a well located above the floor and within the chamber for engagement with the valve stem of the inverted CoMDC; and
a lower portion having a discharge port located in the breathing tube connector for dispensing medicament.

US Pat. No. 10,478,576

LARYNGEAL MASK

Meenakshi Baska, New Sou...

1. A device for maintaining an airway in a patient, the device comprising a mask having a portion that forms a seal with the larynx when the mask is positioned in the laryngo pharynx to thereby prevent ingress of extraneous fluids into the larynx, and an airway tube connected to or formed with the mask for passing gas to the larynx when the mask is properly inserted into the laryngo pharynx, the mask includes a chamber having an opening in fluid communication with the airway tube, the chamber including an outlet through which pressurised gases are supplied to the patient, the chamber including a wall having a wall portion extending from a ventral side of the mask towards a dorsal side of the mask, the wall of the chamber includes a proximal wall portion, opposed side wall portions and a distal portion, the mask includes a soft, flexible portion that contacts tissues surrounding the laryngeal opening when the device is inserted into a patient, the soft, flexible portion being arranged whereby application of pressurised gas to the airway tube urges the soft, flexible portion into contact with the tissues surrounding the laryngeal opening or the pharyngeal wall, the chamber including a region of relatively higher strength or stiffness extending at least partly around a soft, flexible portion surrounding the outlet, wherein the mask includes a proximal portion adapted to collapse or compress so that a proximal ventral part of the mask can move relatively towards a dorsal part of the device during insertion of the mask, the region of relatively higher strength or stiffness being at least partly located in a region between the soft, flexible portion surrounding the outlet of the mask and the proximal portion that is adapted to collapse or compress.

US Pat. No. 10,478,571

DELIVERY APPARATUS AND ACCOMPANYING SYSTEM FOR THE APPLICATION OF A MEDICAL AGENT TO A TREATMENT SITE AND METHOD FOR USE OF SAME

Dualams, Inc., Dallas, T...

1. A delivery apparatus for the application of a medical agent to a treatment site, the medication delivery apparatus comprising:a housing, the housing being sized so as to be securable to a hand-held medical device;
a reservoir configured to contain the medical agent, the reservoir disposed in fluid communication with a supply channel and a circulation channel;
a nebulization housing including a lower chamber and an upper chamber;
the lower chamber being disposed in fluid communication with the supply channel and the circulation channel;
an upper channel being disposed in fluid communication with an airflow channel and a delivery channel;
an ultrasonic transducer positioned in the lower chamber, the ultrasonic transducer configured to generate, upon energization, ultrasonic energy;
a control valve interposed between a source of positive pressure air and the airflow channel, the control valve configured to selectively apply air to the airflow channel;
the reservoir, the supply channel, the circulation channel, the nebulization housing, the airflow channel, the delivery channel, and the control valve being located in the housing;
the control valve being controllable by a controller, the controller being externally positioned on the housing;
a first operational state of the control valve, wherein the control valve is open, wherein the medical agent is configured to circulate from the reservoir to the lower chamber, wherein the ultrasonic transducer is configured to apply ultrasonic energy to the medical agent, thereby producing a nebulized medical agent adapted to be carried by the application of air to the delivery channel; and
a second operational state of the control valve, wherein the control valve is closed, wherein the medical agent is configured to circulate from the reservoir to the lower chamber, wherein the ultrasonic transducer is configured to apply ultrasonic energy to the medical agent, thereby producing a nebulized medical agent adapted to remain in the upper chamber.

US Pat. No. 10,478,570

MEDICATION DELIVERY APPARATUS AND ACCOMPANYING SYSTEM FOR THE APPLICATION OF LOCAL ANESTHETICS TO A TREATMENT SITE AND METHOD FOR USE OF SAME

Dualams, Inc., Dallas, T...

1. A medication delivery apparatus for the application of a local anesthetic to a treatment site, the medication delivery apparatus comprising:a housing;
a reservoir configured to contain the local anesthetic, the reservoir disposed in fluid communication with a supply channel and a circulation channel;
a nebulization housing including a lower chamber and an upper chamber; the lower chamber being disposed in fluid communication with the supply channel and the circulation channel;
a fluid circuit being defined by flow from the reservoir to the supply channel to the lower chamber to the circulation channel;
an upper channel being disposed in fluid communication with an airflow channel and a delivery channel;
an ultrasonic transducer positioned in the lower chamber, the ultrasonic transducer configured to generate, upon energization, ultrasonic energy;
a control valve interposed between a source of positive pressure air and the airflow channel, the control valve configured to selectively apply air to the airflow channel;
a medical device coupling located at a distal end of the delivery channel, the medical device coupling being accessible externally of the housing; the housing being sized so as to be securable to a hand-held medical device via the medical device coupling;
the reservoir, the supply channel, the circulation channel, the nebulization housing, the fluid circuit, the upper channel, the airflow channel, the delivery channel, and the control valve being located in the housing; the control valve being controllable by a controller, the controller being externally positioned on the housing;
a first operational state of the control valve, wherein the control valve is open, wherein the local anesthetic is configured to circulate from the reservoir to the lower chamber, wherein the ultrasonic transducer is configured to apply ultrasonic energy to the local anesthetic, thereby producing a nebulized local anesthetic adapted to be carried by the application of air to the delivery channel; and
a second operational state of the control valve, wherein the control valve is closed, wherein the local anesthetic is configured to circulate from the reservoir to the lower chamber, wherein the ultrasonic transducer is configured to apply ultrasonic energy to the local anesthetic, thereby producing a nebulized local anesthetic adapted to remain in the upper chamber.

US Pat. No. 10,478,566

HUBER SAFETY NEEDLE

Medical Components, Inc.,...

1. A Huber safety needle assembly comprising:a body having an upper portion, a lower portion, and a hinge mechanism;
a needle configured to be received in the body, wherein the needle extends in a first direction from a rear of the assembly to a front of the assembly, makes a 90-degree bend, and extends in a second direction toward a bottom of the assembly which then leads to a needle tip; and
an upper gripping portion coupled to the upper portion and a lower gripping portion coupled to the lower portion;
wherein the hinge mechanism is configured to operably transition the body between a closed configuration and an open configuration by displacing the upper portion and the lower portion from each other relative to a longitudinal axis extending through the needle along the second direction, the closed configuration allowing at least a portion of the needle including the needle tip to extend below a bottom surface of the lower portion of the body, and the open configuration allowing the needle tip to be securely received within the lower portion such that it does not extend below the bottom surface of the lower portion;
wherein the hinge mechanism includes an upper portion, a middle portion, and a lower portion and has a plurality of pivot points, wherein the upper portion of the hinge mechanism couples the hinge mechanism to the upper portion of the body and the lower portion of the hinge mechanism couples the hinge mechanism to the lower portion of the body,
wherein the upper portion of the hinge mechanism is substantially U-shaped and the lower portion of the hinge mechanism is substantially U-shaped such that each of the upper portion of the hinge mechanism and the lower portion of the hinge mechanism can accommodate the needle, and
wherein the hinge mechanism comprises:
an upper pivot point comprising an upper rotatable pin arrangement having a plurality of rotatable pins and configured for coupling the upper portion of the hinge mechanism to each side of the upper portion of the body,
a middle pivot point being a thinned area of material configured to allow the material to bend at the middle portion, and
a lower pivot point comprising a lower rotatable pin arrangement having a plurality of rotatable pins and configured for coupling the lower portion of the hinge mechanism to each side of the lower portion of the body.

US Pat. No. 10,478,565

ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. An assembly for a drug delivery device, the assembly comprising:a housing;
a rotatable clutch member of an elongate shape, the clutch member comprising a clutch feature at a proximal end of the clutch member and teeth at a distal end of the clutch member, wherein the clutch member is axially movable with respect to the housing between a first position and a second position different from the first position;
a further clutch member, wherein the assembly is configured such that,
when the clutch member is in the first position, a clutch engagement established between the clutch feature and the further clutch member is engaged, and
when the clutch member is in the second position, the clutch engagement is released;
a clicker member comprising teeth matching the teeth of the clutch member, the teeth of the clicker member and the teeth of the clutch member forming a coupling between the clutch member and the clicker member;
a counter clicker configured to interact with the clicker member to form a clicker mechanism; and
a spring element arranged between the clicker member and the clutch member, the spring element arranged to move the clutch member towards the first position and away from the clicker member so that the clutch member is rotatable with respect to the clicker member,
wherein the assembly is configured such that,
when the clutch member is in the first position, the clutch member is rotated with respect to the clicker member and the counter clicker rotates with respect to the clicker member, and
when the clutch member is in the second position, a rotation of the clutch member with respect to the clicker member is prevented by the coupling.

US Pat. No. 10,478,561

WIRELESS TRANSMISSION SYSTEM WITH INTEGRATED SENSING CAPABILITY

1. A sensor for detecting a change in state of an asset comprising:a wireless transmission system configured to transmit a control signal to an external device, the wireless transmission system including:
a transmission antenna operable to transmit the control signal to the external device,
control electronics including at least one of a radio frequency identification (RFID) chip and a Bluetooth™ chip in circuit with the transmission antenna configured to provide the control signal to the transmission antenna for transmission to the external device, and
a sensing element including a bypass antenna operable to move from an undisturbed position to a displaced position, the bypass antenna being in parallel with the transmission antenna and the at least one of the RFID chip and the Bluetooth™ chip when in the undisturbed position to suppress the control signal for preventing the wireless transmission system from transmitting the control signal to the external device, and the bypass antenna operable to permit the control signal to be received by the transmission antenna for transmitting the control signal to the external device when the bypass antenna is displaced from the undisturbed position.

US Pat. No. 10,478,557

PERSONALIZED PARAMETER MODELING METHODS AND RELATED DEVICES AND SYSTEMS

Medtronic MiniMed, Inc., ...

1. A method of operating a sensing device associated with a patient, the sensing device including a control module coupled to a sensing element configured to measure a physiological condition in a body of the patient, the method comprising:obtaining, by the control module of the sensing device, current operational context information associated with the sensing device;
obtaining, by the control module, an expected calibration factor parameter model associated with the patient;
calculating, by the control module, an expected calibration factor value based on the expected calibration factor parameter model and the current operational context information;
obtaining, by the control module, one or more electrical signals from the sensing element of the sensing device, the one or more electrical signals having a signal characteristic indicative of the physiological condition in the body of the patient;
converting, by the control module, the one or more electrical signals into a calibrated measurement value for the physiological condition in the body of the patient using the expected calibration factor value; and
outputting, by the control module, the calibrated measurement value for the physiological condition in the body of the patient.

US Pat. No. 10,478,556

PROBABILITY BASED CONTROLLER GAIN

Roche Diabetes Care, Inc....

1. A method for estimating glucose level of a person having diabetes and selecting automatically open-loop and closed-loop control for a connected therapy delivery device, the method comprising:receiving into a blood glucose management device having a microcontroller a plurality of measured glucose results and corresponding impedance values from a glucose sensor coupled to the person;
using the microcontroller to analyze the plurality of measured glucose results and corresponding impedance values with a probability analysis tool configured to determine a total quality score Qtotal that is based on the minimum constraint of a set of quality metrics which comprises a probability of glucose sensor accuracy PA based on the plurality of measured glucose results and a probability of sensing quality Qac based on the impedance values;
using the microcontroller to estimate the glucose level of the person with a recursive filter configured to estimate the glucose level based on the plurality of measured glucose results weighted with the total quality score Qtotal; and
switching, via the microcontroller, the connected therapy delivery device automatically between open-loop control and closed-loop control based on the value of the total quality score Qtotal .

US Pat. No. 10,478,555

SYSTEMS AND METHODS FOR LUMBAR CEREBROSPINAL FLUID ACCESS AND TREATMENT

1. An implantable system for chronic access to cerebrospinal fluid, said system comprising:A multilumen bidirectional fluid flow catheter configured for chronic implantation and placement along a cerebrospinal fluid pathway, wherein said multilumen bidirectional fluid flow catheter comprises a plurality of fluid outlets, and a plurality of fluid inlets
said multilumen bidirectional fluid flow catheter configured to connect, via tunneling, to an assembly comprising at least one finger pumpable dome configured for chronic subcutaneous implantation, each said at least one finger pumpable dome having dual functions of fluid reservoir and pump;
wherein said multilumen bidirectional fluid flow catheter and said at least one finger pumpable dome are further configured to allow simultaneous, bidirectional, cerebrospinal fluid access and cerebrospinal fluid exchange.

US Pat. No. 10,478,543

SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE

The Charles Stark Draper ...

1. A system, comprising:one or more First Channels each defined by a first layer of material and extending in a first direction from a respective first inlet to a respective first outlet;
at least one Second Channel complementary to one or more of the First Channels defined by a second layer of material, the at least one Second Channel extending parallel to the first direction from a second inlet to a second outlet;
a first interchannel flow barrier separating the one or more First Channels from the at least one Second Channel;
at least one Third Channel, defined by a third layer of material, complementary to one or more of the First Channels, the at least one Third Channel extending parallel to the first direction from a third inlet to a third outlet;
a first structural support within the at least one Third Channel configured to limit deformation of a second interchannel flow barrier, wherein the first structural support has a length that is less than a length of the at least one Third Channel and the second interchannel flow barrier separates the one or more First Channels from the at least one Third Channel;
a blood introduction device;
a filtrate introduction device; and
a control system coupled with the blood introduction device and the filtrate introduction device, the control system comprising:
at least one fluid pressure sensor configured to measure fluid pressure characteristics in the one or more First Channels;
at least one fluid flow sensor configured to measure fluid flow characteristics in the one or more First Channels; and
a processor in communication with the blood introduction device, the filtrate introduction device, the at least one fluid pressure sensor, and the at least one fluid flow sensor;
wherein the control system is configured to control an amount of convective clearance of blood flowed through the one or more First Channels by:
controlling the blood introduction device to flow blood through the one or more First Channels,
increasing a rate at which infusate is introduced into the at least one Second Channel responsive to a measurement received from the at least one fluid pressure sensor or the at least one fluid flow sensor, to cause a net infusion of fluid from the at least one Second Channel into the one or more First Channels and to cause a net outflow of fluid from the one or more First Channels into the at least one Third Channel in a direction perpendicular to a plane of the first layer of material defining the one or more First Channels.

US Pat. No. 10,478,539

CATHETER DEVICE

AIS GMBH AACHEN INNOVATIV...

1. A catheter device comprising:a drive shaft having a proximal end and a distal end;
a rotor, connected to the drive shaft;
a pump head comprising an inlet, an outlet, and an expandable and collapsible pump housing having a proximal end and a distal end, wherein the rotor is located in the expandable and compressible pump housing;
a body cap, wherein the body cap has a proximal end and a distal end, the proximal end being coupled to a distal end of the pump head by a body element, and wherein the body cap comprises an atraumatic ball; and
the body element is an elongate tubular flexible projection, having proximal and distal ends, that projects distally away from the distal end of the pump housing and forms a flexible connection between the body cap and the distal end of the pump housing, wherein the proximal end of the atraumatic ball is positioned distally relative to the distal end of the body element.

US Pat. No. 10,478,538

FLEXIBLE CATHETER WITH A DRIVE SHAFT

ECP ENTWICKLUNGSGESELLSCH...

1. A flexible catheter comprising:a drive shaft;
a sleeve surrounding the drive shaft; and
a sheath surrounding the drive shaft and the sleeve, wherein the drive shaft, the sleeve and the sheath are configured to be pliable, wherein the drive shaft at a proximal end of the drive shaft comprises a coupling element for connecting the drive shaft to a drive motor; and
wherein the drive shaft has an outer diameter of less than 1 mm, and at least in regions consists of a material configured to have a tensile strength between 1800 N/mm2 and 2400 N/mm2.

US Pat. No. 10,478,537

CELL SEPARATION FILTER MATERIAL AND FILTER OBTAINED BY LAYERING SAME

KANEKA CORPORATION, Kita...

1. A filter comprising:an inlet and an outlet for a liquid; and
at least two nonwoven fabrics stacked in a liquid flow direction,
wherein
a nonwoven fabric, of the at least two nonwoven fabrics, on an inlet side of the filter, and a nonwoven fabric, of the at least two nonwoven fabrics, on an outlet side of the filter have an average fiber diameter of from 0.3 to 5.0 ?m,
a thickness of from 0.10 to 0.60 mm,
a basis weight of from 10 to 100 g/m2, and
an average floc size index of from 1.0 to 4.0.

US Pat. No. 10,478,536

THERAPY APPARATUS WITH INTEGRATED FLUID CONDUCTORS AND NOISE ATTENUATION

KCI Licensing, Inc., San...

1. An apparatus for providing negative-pressure therapy, the apparatus comprising:a first housing;
a second housing configured to be coupled to the first housing;
a panel having an inner surface and an outer surface, the inner surface facing the first housing, the panel coupled to the second housing;
a first fluid channel integrated into the outer surface of the panel;
a second fluid channel integrated into the outer surface of the panel;
a first channel port integrated into the panel and fluidly coupled to the first fluid channel;
a second channel port integrated into the panel and fluidly coupled to the second fluid channel;
a pump disposed between the first housing and the second housing, the pump comprising a negative-pressure port fluidly coupled to the first channel port and a positive-pressure port fluidly coupled to the second channel port;
a canister port coupled to the panel and fluidly coupled to the first fluid channel upstream of the negative-pressure port;
an expansion chamber coupled to the panel and fluidly coupled to the second fluid channel downstream of the positive-pressure port; and
an adhesive label coupled to the panel over the first fluid channel and the second fluid channel.

US Pat. No. 10,478,533

VACUUM ASSISTED IRRIGATION PUMP

Megadyne Medical Products...

1. A device for the pressurization of fluid for medical procedures, the device comprising:a flexible chamber, the flexible chamber being configured to be associated with a fluid reservoir;
first and second compressive members associated with the flexible chamber, at least portions of the flexible chamber and the second compressive member being disposed on opposing sides of the first compressive member such that the first compressive member is disposed at least partially between the flexible chamber and the second compressive member, the second compressive member being configured to move closer to the first compressive member as a result of a decrease in a volume of the flexible chamber, wherein decreasing the volume of the flexible chamber draws the second compressive member closer to the first compressive member;
a conduit configured to provide fluid communication between an exterior and an interior of the flexible chamber.

US Pat. No. 10,478,532

VACUUM CONTROL METHOD FOR SURGICAL HAND PIECE

Alcon Research, Ltd., Fo...

1. A surgical hand piece comprising:a hand piece body;
a probe operatively coupled to the hand piece body;
an aspiration passage defined through the probe and hand piece body;
an aspiration pump integrated within the hand piece body, the aspiration pump operable to generate an aspirated flow along the aspiration passage; and
a check valve disposed within the hand piece body between the aspiration passage and a vacuum line that couples the check valve to a vacuum source, the check valve comprising:
a moveable element; and
a sealing surface formed by a rim of the vacuum line, the check valve in an open condition when the moveable element is separated from the sealing surface and in a closed condition when the moveable element contacts the sealing surface to form a seal,
wherein the check valve is adapted to open when a pressure within the aspiration passage falls below a selected level of pressure.

US Pat. No. 10,478,522

BIOCOMPATIBLE MATERIAL IN GRANULES MADE OF METAL MATERIAL OR METAL ALLOYS AND USE OF SAID GRANULES FOR VERTEBROPLASTY

1. A granule made of biocompatible metal material or alloys of said metal material, wherein said granule comprises a solid spherical structure with an outer diameter of between 3 and 4 millimeters, and an outer surface having a trabeculated porous structure, wherein the trabeculated pores of the outer surface have a diameter of between 400 and 800 microns.

US Pat. No. 10,478,519

TISSUE SUBSTITUTE MULTILAYER MATRIX AND USES THEREOF

NURAMI MEDICAL LTD., Naz...

1. A composition-of-matter comprising a multi-layer matrix, said matrix comprising at least one layer of an elastic polymeric material and at least one layer of a viscoelastic polymeric material, wherein at least one layer of said elastic polymeric material is in a form of a porous layer of polymeric fibers, and wherein said viscoelastic polymeric material comprises a polymer characterized by a glass transition temperature and/or melting point at a temperature below 40° C., said elastic polymeric material comprises a polymer characterized by a glass transition temperature and/or melting point at a temperature above 40° C., and wherein said layer of said viscoelastic polymeric material is characterized by a loss tangent (G?/G?) at a temperature of 10° C. and frequency of 0.1 Hz which is in a range of from 0.01 to 4.

US Pat. No. 10,478,518

METHOD FOR DISINFECTING CONTACT LENSES

Better Vision Solutions L...

1. A method for disinfecting contact lenses, the method comprising:immersing the contact lenses in a volume of cleaning agent comprising about 3% hydrogen peroxide for up to 4 hrs; and
increasing the disinfection efficacy of and creating stable hydroxyl groups in the hydrogen peroxide by immersing up to 0.7 g of a fibrous catalyst enhancer material in the volume of cleaning agent for up to 4 hrs, the fibrous catalyst enhancer material being immersed simultaneously with the contact lenses, wherein the fibrous catalyst enhancer material comprises covalently attached iron cation.

US Pat. No. 10,478,515

MULTI WAVE STERILIZATION SYSTEM

Sensor Electronic Technol...

1. A system comprising:a set of ultraviolet radiation sources configured to generate ultraviolet radiation directed within a storage area; and
a monitoring and control system for managing the storage area by performing a method comprising:
enabling selection of each of a plurality of selectable operating configurations, the plurality of selectable operating configurations including: a virus destruction operating configuration, a bacteria disinfection operating configuration, and a condition monitoring operating configuration, wherein each operating configuration includes a unique combination of a target wavelength, a target intensity range, and a target pattern for the ultraviolet radiation;
monitoring a set of current conditions of at least one of: the storage area or a set of items located in the storage area, wherein the set of current conditions includes a visual appearance of the at least one of: the storage area or the set of items located in the storage area; and
controlling ultraviolet radiation generated by the set of ultraviolet radiation sources using a selected one of the plurality of selectable operating configurations and the set of current conditions.

US Pat. No. 10,478,514

METHODS FOR INACTIVATING, ON MEDICAL INSTRUMENTS AND DEVICES, VIRUSES CONTAINING RNA AND DNA, AND APPARATUSES FOR IMPLEMENTATING SAME

1. A method for inactivating RNA and DNA contained in viruses on medical instruments, comprising:preparing a methylene blue aqueous solution having a concentration from about 0.01% to about 0.02%,
immersing at least one medical instrument into a container containing said methylene blue aqueous solution, said container being within a housing;
sealing said container within said housing; and
irradiating, by a monochromatic light source within said housing and above said container, said methylene blue aqueous solution in said container with monochromatic radiation for at least about 90 minutes,
wherein said monochromatic light source emits a total light output of said monochromatic radiation on said methylene blue aqueous solution greater than about 280 lumens,
whereby RNA and DNA of viruses on said at least one medical instrument are inactivated.

US Pat. No. 10,478,513

NITROXIDE CONTAINING AMYLOID BINDING AGENTS FOR IMAGING AND THERAPEUTIC USES

THE REGENTS OF THE UNIVER...

1. A method of imaging amyloid, comprising:administering to a subject an effective amount of a compound having the structure of Formula I:
X—(Y)n  (I)
wherein
X is an amyloid beta binding compound selected from the group consisting of:

wherein
Ra and Rb are each independently H or C1-4 alkyl;
Z is selected from the group consisting of I, 123I, 125I, 131I, Br, 76Br, 77Br, F, 18F, and —O-tosyl; and
q is an integer from 2 to 5;
Y is a nitroxide selected from the group consisting of:

n is an integer from 1 to 3;
such that the compound binds to the amyloid; and
detecting the compound bound to the amyloid, thereby imaging the amyloid.

US Pat. No. 10,478,512

CHARGE-BALANCED IMAGING AGENTS

Beth Israel Deaconess Med...

1. A method of imaging tissue or cells, the method comprising:(a) contacting the tissue or cells with an imaging agent comprising a dye;
(b) irradiating the tissue or cells at a wavelength absorbed by the dye;
(c) detecting an optical signal from the irradiated tissue or cells, wherein the signal-to-background ratio of the detected optical signal is at least about 1.1, thereby imaging the tissue or cells;
wherein the dye has the formula V:

wherein:
G is -L-TL, where TL is a targeting ligand comprising at least one binding moiety that binds to a biological target;
L has the formula:

E is absent or S;
Q is (CH2)q or a non-ionic oligomeric or polymeric solubilizing moiety;
J is C(O), C(O)O, or C(O)NH;
R17, R18, R19, and R12 are independently selected from H, an ionic group, a non-ionic oligomeric or polymeric solubilizing group, halo, cyano, nitro, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkyl;
q is 0, 1, 2, 3, 4, 5, 6, 7, or 8;
R1, R2, R3, R4, R5, R6, R7, and R8 are independently selected from H, an ionic group, a non-ionic oligomeric or polymeric solubilizing group, halo, C1-6 alkyl, aryl, and heteroaryl, wherein said alkyl, aryl, and heteroaryl groups are optionally substituted with 1, 2, 3, 4, or 5 groups independently selected from halo, cyano, nitro, and C1-4 haloalkyl;
or two adjacent R1, R2, R3, R4, R5, R6, R7, and R8 groups, together with the atoms to which they are attached, form a fused 5-7 membered aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group, each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from halo, cyano, nitro, and C1-4 haloalkyl;
R9, and R10, are independently selected from an ionic group, a non-ionic oligomeric or polymeric solubilizing group, C1-6 alkyl, aryl, and heteroaryl, wherein said alkyl, aryl, and heteroaryl groups are optionally substituted with 1, 2, 3, 4, or 5 groups independently selected from halo, cyano, nitro, and C1-4 haloalkyl;
R11 and R12 are independently selected from C1-4 alkyl optionally substituted with 1, 2, or 3 halo;
R13 and R14 are independently selected from C1-4 alkyl optionally substituted with 1, 2, or 3 halo;
R15 and R16 are independently selected from H and C1-6 alkyl;
R22, R23, R24, R25, R26, and R27 are independently selected from independently an ionic group, a non-ionic oligomeric or polymeric solubilizing group, halo, C1-6 alkyl, aryl, and heteroaryl; and
v is 0, 1, 2, 3, 4, or 5,
wherein at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is an ionic group,
or an ester thereof, which permits covalent conjugation of the fluorophore to targeting ligands.

US Pat. No. 10,478,492

MODIFICATIONS OF THERAPEUTIC AGENTS FOR ENHANCED DELIVERY TO TARGET SITES

CLARIA PARTIKULA LLC, Da...

1. A compound selected from the group consisting of:

US Pat. No. 10,478,460

METHOD FOR IDENTIFYING A MAMMAL RECEPTIVE TO EMBRYO TRANSFER

J.R. Simplot Company, Bo...

1. A method for improving the pregnancy rate of a cow population via an embryo transfer procedure, comprising:a) synchronizing estrous cycles of a population of cows;
b) performing an estrus detection procedure upon said population of cows from step a) and identifying a subpopulation of cows, which are not in heat or do not show outward signs of heat, from said population of cows from step a) by performing the estrus detection procedure;
c) testing one or more cows from said subpopulation of cows from step b), which are not in heat or do not show outward signs of heat, for the presence or absence of a corpus luteum;
d) identifying a cow from step c) that has a corpus luteum based upon said testing; and
e) transferring an embryo to the cow identified as having the corpus luteum in step d) and testing said cow for pregnancy,
wherein an improved pregnancy rate of the cow population is achieved.

US Pat. No. 10,478,455

THERAPEUTIC USE OF TETRATHIOMOLYBDATE

UCL BUSINESS LTD, London...

1. A method for acute treatment of ischemia-reperfusion injury (IRI) in a subject that has undergone ischemic injury and is now at risk for acute injury caused by reperfusion following said ischemic injury, wherein said method comprises administering, to said subject, tetrathiomolybdate (TTM), via continuous infusion, wherein a total dose of up to 20 mg/kg TTM is administered to the subject over a period of one hour or less, such that within two hours of initiating treatment with TTM, there occurs in the subject a decrease in at least one of oxygen consumption and carbon dioxide production, thereby providing acute treatment of said IRI.

US Pat. No. 10,478,454

TREATMENT OF ALZHEIMER'S DISEASE (AD) WITH ALUMINUM OXYHYDROXIDE

AFFIRIS AG, Vienna (AT)

1. A method for treating Alzheimer's Disease (AD), the method comprising administering a pharmaceutical preparation to an AD patient, said pharmaceutical preparation comprising a European Pharmacopoeia grade aluminum oxyhydroxide in an amount of at least 1.2 mg as a single effective ingredient to treat AD.

US Pat. No. 10,478,445

BORONIC ACID DERIVATIVES OF RESVERATROL FOR ACTIVATING DEACETYLASE ENZYMES

Georgetown University, W...

1. A method comprising administering a composition to a subject, wherein the composition comprises a compound, or a pharmaceutically acceptable salt, prodrug, clathrate, tautomer or solvate thereof, wherein the compound has the structure:
wherein
R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently hydrogen, hydroxyl, —B(OH)2, alkyl, alkenyl, alkynyl, halo, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, alkoxydialkylamino, aminocarbonyl, alkylaminocarbonyl, dialkylamino carbonyl, haloalkyl, haloalkloxy, haloalkylamino, or di(haloalkyl)amino;
R8 and R9 are optionally cyclized to form cycloalkyl, aryl, heteroaryl or heterocyclyl, optionally substituted with —B(OH)2, mild Lewis acid, strong acid, weak acid, alkyl, alkenyl, alkynyl, halo, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, alkoxydialkylamino, aminocarbonyl, alkylaminocarbonyl, dialkylamino carbonyl, haloalkyl, haloalkloxy, haloalkylamino, di(haloalkyl)amino or sugars;
L is
or L is absent when R8 and R9 are cyclized;wherein at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is or includes —B(OH)2, and at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 is or includes alkoxy, alkoxydialkylamino or hydroxyl,
wherein the compound is a deacetylase activator, wherein the subject is in need of treatment of a disease or condition, wherein the disease or condition is associated with expression of a deacetylase enzyme, and wherein cells of the subject express mutant p53, under-express SIRT1, have low SIRT1 activity, or combinations thereof.

US Pat. No. 10,478,444

METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING VIRAL INFECTIONS

Enterin, Inc., Philadelp...

1. An in vivo method of treating or preventing a viral infection in a mammal comprising administering a composition comprising:(a) a pharmaceutically acceptable grade of squalamine or a pharmaceutically acceptable salt or derivative thereof in an amount sufficient to produce an antiviral effect, and
(b) at least one pharmaceutically acceptable carrier,
wherein the viral infection is caused by a virus selected from the group consisting of Yellow Fever, Eastern Equine Encephalitis virus, Human Immunodeficiency virus (HIV), “African Swine Fever Viruses,” Arbovirus, Adenoviridae, Arenaviridae, Arterivirus, Astroviridae, Baculoviridae, Bimaviridae, Bimaviridae, Bunyaviridae, Caliciviridae, Caulimoviridae, Circoviridae, Coronaviridae, Cystoviridae, EBV, Deltaviridae, Filviridae, Filoviridae, Flaviviridae, Iridoviridae, Mononegavirus, Myoviridae, Papiloma virus, Papovaviridae, Paramyxoviridae, Prions, Parvoviridae, Phycodnaviridae, Poxviridae, Potyviridae, Reoviridae, Retroviridae, Rhabdoviridae, Tectiviridae, Togaviridae, pox, papilloma, corona, influenza, sendai virus (SeV), sindbis virus (SINV), vaccinia viruses, West Nile, Hanta, viruses which cause the common cold, and any combination thereof, and
wherein the composition is systemically administered intravenously, subcutaneously, intramuscularly, orally, or by inhalation.

US Pat. No. 10,478,443

SEX STEROID PRECURSORS ALONE OR IN COMBINATION WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE PREVENTION AND TREATMENT OF SEXUAL DYSFUNCTION IN POSTMENOPAUSAL WOMEN

ENDORECHERCHE, INC., (CA...

1. A method of treating or reducing the likelihood of acquiring a vaginal disease or condition caused by the atrophy of either or both of the layer lamina propria and/or the layer muscularis of the vagina in postmenopausal women, wherein said disease or condition is sexual dysfunction other than dyspareunia, said method comprising administering a sex steroid precursor that is dehydroepiandrosterone, to a patient in need of said treatment and also administering to said patient, as part of a combination therapy, a selective estrogen receptor modulator that is:

US Pat. No. 10,478,440

PHARMACEUTICAL COMPOSITIONS FOR INHIBITING ANGIOGENESIS COMPRISING PLANT-DERIVED NATURAL COMPOUND

INDUSTRY-ACADEMIC COOPERA...

1. A method for treating cancer selected from the group consisting of lung cancer, breast cancer, pancreatic cancer, thyroid cancer, and glioblastoma the method comprising administering to a subject in need thereof, a composition comprising as an active ingredient a compound represented by Chemical Formula 1 below:wherein, R1, R2, and R3 each are independently hydrogen, C1-12 alkyl, C1-12 alkoxy, hydroxy, CN, CONH2, halo, oxazolyl, C1-12 alkylthio, or trifluoro(C1-2) alkyl.

US Pat. No. 10,478,437

COMBINATION THERAPY TO ENHANCE THE ANTICANCER EFFICACY OF PLATINUM DRUGS

1. A method for reducing cancer cell proliferation and/or promoting cancer cell death by administering, to a cancer cell, an effective amount of a compound having a formula selected from the group consisting of Formula I:wherein G is C; Q is C; and R is selected from H, a substituted or unsubstituted alkyl, a fluorinated or partially fluorinated alkyl, a halogen, cyano, azido, hydroxyl, a substituted or unsubstituted sulfonyl;

US Pat. No. 10,478,433

UNIT DOSE OF AN ARYL SULFONAMIDE THAT IS EFFECTIVE FOR TREATING EYE DISEASE AND AVERTING POTENTIAL VISION LOSS

Unity Biotechnology, Inc....

17. A unit dose containing an effective amount of a compound having the following formula, or a pharmaceutically effective salt thereof;
wherein the unit dose is formulated as a pharmaceutical composition in an excipient in a volume suitable for intraocular administration into an eye of a subject in need thereof;
wherein the amount of the compound in the unit dose renders the unit dose effective for treating an ophthalmic disease or disorder in the eye that is not a cancer.

US Pat. No. 10,478,429

ABUSE DETERRENT DOSAGE FORMS

Patheon Softgels, Inc., ...

1. A controlled release oral pharmaceutical composition comprising:(a) about 35% to about 70% by mass glyceryl monolinoleate;
(b) about 20% to about 50% by mass polyethylene oxide having an average molecular weight (Mv) of about 1,00,000 to about 7,000,000; and
(c) one or more active pharmaceutical ingredients.

US Pat. No. 10,478,428

COMBINATION THERAPY FOR CANCER TREATMENT

Ipsen Biopharm Ltd., (GB...

1. A method of treating a patient having a solid tumor, the method comprisingi) administering to the patient liposomal irinotecan once every two weeks; and
ii) administering a Poly(ADP-ribose) Polymerase (PARP) inhibitor daily for 3 to 10 days between consecutive administrations of the liposomal irinotecan wherein the PARP inhibitor starting at least 2 days after the liposomal irinotecan and ending at least 1 day prior to the administration of additional liposomal irinotecan, wherein the patient has been diagnosed with ovarian cancer.

US Pat. No. 10,478,426

ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS

GLAXOSMITHKLINE LLC, Wil...

1. A method of treating a hematologic cancer comprising administering to a patient with cancer a therapeutically effective amount of a compound of formula (I):
wherein:
R1 is methyl;
R2 is methyl;
R3 is hydrogen;
R4 is methyl;
R5 is —NRaRb;
R6 is phenyl, wherein said phenyl is optionally substituted by —(C1-C6)alkyl(Rc);
Rc is —NRaRb; and
Ra and Rb are each independently hydrogen, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C10)cycloalkyl, (C5-C8)cycloalkenyl, heterocycloalkyl, or aryl, wherein said (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or aryl group is optionally substituted by 1, 2 or 3 groups independently selected from the group consisting of halo, hydroxyl, (C1-C4)alkoxy, amino, (C1-C4)alkylamino, —N((C1-C4)alkyl)2, —CO2H, —CO2(C1-C4)alkyl, —CONH2, —CONH(C1-C4)alkyl, —CON((C1-C4)alkyl)2, —SO2(C1-C4)alkyl, —SO2NH2, —SO2NH(C1-C4)alkyl, and —SO2N((C1-C4)alkyl)2; and wherein said heterocycloalkyl is selected from the group consisting of pyrrolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, and tetrahydropyranyl;
or Ra and Rb taken together with the nitrogen to which they are attached represent a 5 or 6 membered saturated ring, optionally containing an additional heteroatom selected from oxygen, nitrogen, and sulfur, wherein said ring is optionally substituted by 1, 2 or 3 groups independently selected from the group consisting of (C1-C4)alkyl, (C1-C4)haloalkyl, amino, (C1-C4)alkylamino, ((C1-C4)alkyl)((C1-C4)alkyl)amino, hydroxyl, oxo, (C1-C4)alkoxy, and (C1-C4)alkoxy(C1-C4)alkyl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,478,409

PHARMACEUTICAL COMPOSITIONS

Kalvista Pharmaceuticals ...

1. A process for preparing an aqueous pharmaceutical suspension composition suitable for parenteral administration in a mammalian patient, the aqueous pharmaceutical suspension comprising a compound of formula I having an aqueous solubility of less than 1 mg/mL:wherein:R1 is H, alkyl, —COalkyl, —COaryl, —COheteroaryl, —CO2alkyl, —(CH2)aOH, —(CH2)bCOOR10, —(CH2)cCONH2, —SO2alkyl, or —SO2aryl;
R2 is H or alkyl;
R3 is H, alkyl, —(CH2)daryl, —(CH2)eheteroaryl, —(CH2)fcycloalkyl, —(CH2)gheterocycloalkyl, —CH(cycloalkyl)2, or —CH(heterocycloalkyl)2;
R4 and R6 are independently H or alkyl;
R5 is H, alkyl, alkoxy, or OH;
or R4 and R5, together with the atoms to which they are attached, form a 5- or 6-membered azacycloalkyl structure;
R7 and R8 are independently H, alkyl, alkoxy, CN, or halo;
R9 is aryl or heteroaryl;
R10 is H or alkyl;
a, b, c, d, e, f and g are, independently, 1, 2 or 3;
*1 and *2 denote chiral centres;
alkyl is a linear saturated hydrocarbon having up to 10 carbon atoms (C1-C10) or a branched saturated hydrocarbon of between 3 and 10 carbon atoms (C3-C10); wherein the alkyl is optionally substituted with 1 or 2 substituents that are, independently, (C3-C10)cycloalkyl, (C1-C6)alkoxy, OH, CN, CF3, COOR11, fluoro, or NR11R12;
cycloalkyl is a mono- or bi-cyclic saturated hydrocarbon of between 3 and 10 carbon atoms; wherein the cycloalkyl is optionally fused to an aryl group;
heterocycloalkyl is a C-linked or N-linked 3 to 10 membered saturated, mono- or bi-cyclic ring, wherein said heterocycloalkyl ring comprises 1, 2 or 3 heteroatoms that are, independently, N, NR11, or O;
alkoxy is a linear O-linked hydrocarbon of between 1 and 6 carbon atoms (C1-C6) or a branched O-linked hydrocarbon of between 3 and 6 carbon atoms (C3-C6); wherein the alkoxy is optionally substituted with 1 or 2 substituents that are, independently, (C3-C10)cycloalkyl, OH, CN, CF3, COOR11, fluoro, or NR11R12;
aryl is phenyl, biphenyl or naphthyl; wherein the aryl is optionally substituted with up to 5 substituents that are, independently, alkyl, alkoxy, OH, halo, CN, COOR11, CF3, or NR11R12;
heteroaryl is a 5, 6, 9 or 10 membered mono- or bi-cyclic aromatic ring containing 1, 2 or 3 ring members that are, independently, N, NR11, S and O; wherein the heteroaryl is optionally substituted with 1, 2 or 3 substituents that are, independently, alkyl, alkoxy, OH, halo, CN, COOR11, CF3, or NR11R12;
R11 and R12 are H or alkyl;
or a tautomer, stereoisomer, pharmaceutically acceptable salt, or solvate thereof;
the process comprising suspending particles of the active ingredient that is a compound of formula I, or a pharmaceutically acceptable salt thereof, in an aqueous vehicle.

US Pat. No. 10,478,407

PHARMACEUTICAL COMPOSITION FOR VIRAL INFECTIONS

THE ADMINISTRATORS OF THE...

1. A method of reducing the severity or the duration of the symptoms of a viral infection selected from herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella zoster virus (VZV), in a subject in need thereof, the method comprising administering to the subject in need thereof a pharmaceutical composition comprising C12-C14-alkyl(ethylbenzyl)dimethylammonium chloride.

US Pat. No. 10,478,390

USE OF GLYCOSIDES TO INCREASE HAIR MASS

1. A cosmetic method for increasing the diameter of hair fiber of an individual desiring such, which comprises applying to the scalp of said individual in order to increase the diameter of hair fiber at least one glycoside have the following formula (II):
X being —O—, —C(Ra)=N—O— or —C(Rb)(Rc)-
i is 0 or 1;Ra representing H or a linear or branched (C1-C6)alkyl group,Rb and Rc, are identical or different, representing H or a group chosen from the group consisting of hydroxy, alkoxy(C1-C6), alkoxy(C1-C6)amino, alkoxy(C1-C6)ammonium, alkoxy(C1-C6)-diamino, amino, (C1-C6)alkylamino, di((C1-C6)alkyl)amino, hydroxy(C1-C6)alkylamino, di(hydroxy(C1-C6)alkyl)amino, and (hetero)arylamino groups;R represents a (C1-C10)alkyl, linear or branched, said alkyl group being possibly substituted by at least one substituent chosen from the group consisting of ORa, —C(O)OH and —C(O)OR?2, R?2 being a linear or branched (C1-C4)alkyl group;or R represents a (C1-C4)alkyl(C6-C10)aryl group, said aryl group being optionally substituted by at least one substituent ORe, Re representing H or a linear or branched (C1-C6)alkyl group;the bond representing a bond of a C-anomeric nature, which is ? or ?,as well as the salts thereof, the solvates thereof and the optical and geometric isomers thereof.

US Pat. No. 10,478,383

STERILIZABLE DENTAL ROOL CANAL FILLING COMPOSITION, POINTS/CONES MADE OF SAME, AND PROCESS OF STERILIZING SAME

DENTSPLY SIRONA Inc., Yo...

1. A root canal filling composition, comprising:a plurality of Gutta Percha polymers having different Mooney index values;
an antioxidant of particles having a particle size of 1000 nm or less; and
a filler of particles having a particle size of 1000 nm or less,
wherein the composition can substantially maintain its physical and chemical characteristics and shelf life after sterilization by irradiation.

US Pat. No. 10,478,382

MEDICAL CONNECTING DEVICE

Carmel Pharma AB, Gothen...

1. A bottle connector for use in a medical fluid transfer arrangement, said bottle connector having an axial direction and a radial direction and comprising:a first generally cylindrical part having a first end a second end, said first generally cylindrical part comprising a hollow piercing member comprising an inner channel, said hollow piercing member defining a length and extending in said axial direction from an interior portion of said first generally cylindrical part beyond said second end of said first generally cylindrical part; and
a second generally cylindrical part having a first end and a second end, said second generally cylindrical part comprising a bottle coupling member, for coupling said bottle connector to a medical bottle,
wherein said first and second generally cylindrical parts are connected and concentrically arranged with respect to each other, such that when said second part is coupled to said medical bottle said piercing member is aligned in an axial direction of said medical bottle with a sealing member of said medical bottle, and the generally cylindrical second part is releasably locked to the first generally cylindrical part and transitionable between a transport configuration and a fluid transfer configuration,
wherein when said bottle connector is in the transport configuration, said bottle connector defines a length between said first end of said first generally cylindrical part and said second end of said second generally cylindrical part, wherein said length is greater than said length of said hollow piercing member so that the hollow piercing member protrudes past the second end of the first generally cylindrical part and so that the second generally cylindrical part completely shields said hollow piercing member, and when said bottle connector is in the fluid transfer configuration, at least a portion of said hollow piercing member extends beyond said second end of said first generally cylindrical part, and wherein the first and second generally cylindrical parts are configured to telescope with respect to each other when transitioning from the transport configuration to the transfer configuration other without rotation between them, wherein the second generally cylindrical part is configured to move from an unlocked configuration corresponding to the first and second generally cylindrical parts not being locked together, to the transport configuration, and wherein, when the second generally cylindrical part moves from the unlocked configuration to the transport configuration, the second generally cylindrical part moves along a longitudinal axis without rotation.

US Pat. No. 10,478,375

PULMONARY EXPANSION THERAPY DEVICES

Peter Antros, Bourbonnai...

1. A medical device comprising:an inflow tube;
an outflow tube;
a shell that houses a negative pressure lumen operatively coupled to the outflow tube and a positive pressure chamber operatively coupled to the inflow tube, wherein the shell is generally contoured to the triangular shape of a single human lung within a chest wall;
a membrane operatively coupled to the negative pressure lumen; and
a handle connected to the shell.

US Pat. No. 10,478,371

MEDICAL REHAB BODY WEIGHT SUPPORT SYSTEM AND METHOD WITH HORIZONTAL AND VERTICAL FORCE SENSING AND MOTION CONTROL

Gorbel, Inc., Fishers, N...

1. A system for supporting weight-bearing therapies of a person, comprising:a movable support unit operatively associated with and moveable along or relative to a support system, the movable support unit being movable along a path;
at least a first drive associated with the movable support unit, said first drive moving the movable support unit along the path;
an actuator attached to the movable support unit, said actuator including a second drive for driving a rotatable drum, said drum having a first end of a strap attached thereto, said strap wound in an overlapping coil fashion about an outer surface of the drum, and a second end of the strap being coupled to a support harness attached to support the person;
a first sensor configured to measure a magnitude and a direction of a horizontal force applied to the movable support unit via the strap;
a second sensor configured to measure, as a tensile force, at least a magnitude of a vertical force applied to the strap;
a control system configured to receive signals from the first and second sensors and a user interface, the control system configured to control, in response to the received signals, the movement of at least the first and second drives to facilitate the support during movement of the person, where the control system dynamically adjusts the amount of support provided to the person by moving the movable support unit horizontally along the track to follow the person and by dynamically altering the vertical force applied to the person via the strap, the drum and the second drive; and
a database for storing data representative of the operation of the system, said database being associated with the control system and where the user interface directs queries to said database, said system providing, in response to a query, at least one report selected from the group consisting of: a patient record, task outcomes, session outcomes, and historical comparisons.

US Pat. No. 10,478,368

FORCE TRANSMITTING FRAMES AND MOTION ASSISTANCE APPARATUSES INCLUDING THE SAME

Samsung Electronics Co., ...

1. A force transmitting frame having a length greater than a width, wherein stiffnesses of first and second end portions of the force transmitting frame are greater than a stiffness of a central area of the force transmitting frame in a longitudinal direction of the force transmitting frame, the force transmitting frame comprising:an inner frame configured to support one side of a user; and
an outer frame of which first and second end portions are fixed to first and second end portions of the inner frame, respectively, and of which a central portion is not fixed to a central portion of the inner frame, wherein
the central portion of the outer frame is configured to slide with respect to the central portion of the inner frame.

US Pat. No. 10,478,365

PHYSICAL ASSISTIVE ROBOTIC SYSTEMS

Illinois Institute of Tec...

1. A physical assistive robotic device comprising:a frame comprising an upright support member;
a lateral member slidably engaged with the upright support member;
a handle slidably engaged with the lateral member;
an elevation actuator coupled to the upright support member and the lateral member;
a lateral actuator coupled to the lateral member and the handle, wherein the elevation actuator translates the lateral member and the lateral actuator translates the handle to transition a user between a standing position and a non-standing position;
an additional lateral member slidably engaged with the upright support member and coupled to the elevation actuator;
an additional handle slidably engaged with the additional lateral member;
an additional lateral actuator coupled to the additional lateral member and the additional handle wherein, the elevation actuator translates the additional lateral member and the additional lateral actuator translates the additional handle to transition the user between the standing position and the non-standing position;
an electronic control unit comprising a processor for executing machine readable instructions and an electronic memory for storing the machine readable instructions; and
a posture detector coupled to the upright support member and communicatively coupled with the electronic control unit, wherein the posture detector is a camera,
wherein the posture detector captures image data of at least a portion of the user and outputs the image data to the electronic control unit; and
the electronic control unit executes the machine readable instructions to:
receive the image data;
determine whether a user posture is an improper posture based on the image data; and
provide an alert when the user posture is determined to be an improper posture.

US Pat. No. 10,478,363

CLAMPING CLAW FOR MOUNTING ON A SLIDING RAIL OF AN OPERATING TABLE

MAQUET GMBH, Rastatt (DE...

1. An operating table clamp for mounting on an operating table member, comprising:a base body;
a clamp assembly disposed on the base body, the clamp assembly having a bearing member configured to bear against the operating table member; and
an activating member that is connected to the clamp assembly, the clamp assembly being brought by the activating member into a locked state in which the bearing member of the clamp assembly bears against the operating table member;
wherein in the locked state of the clamp assembly, the bearing member engages with an edge region of the operating table member, the edge region including an edge that is disposed between a first operating table member surface and a second operating table member surface, the first and second operating table member surfaces being angled relative to each other;
wherein the bearing member includes a first contact surface, a second contact surface, and an edge recess, the edge recess being disposed between the first and second contact surfaces;
wherein the first contact surface bears against the first operating table member surface, and the second contact surface bears against the second operating table member surface;
wherein the edge recess receives the edge region of the operating table member without the edge of the operating table member contacting a surface of the edge recess; and
wherein the bearing member comprises a swivel bar having a first end and a second end, the swivel bar being pivotally mounted at its first end at the base body, and the swivel bar having two convex arched surfaces forming said first contact surface and said second contact surface at the second end of the swivel bar.

US Pat. No. 10,478,357

BANDAGE AND MEDICAL FABRICS DISPENSERS

Rowan University, Glassb...

1. A dispenser comprising:a case defining a first opening extending therethrough;
a supply reel rotatably mounted within the case and having a hub;
a take-up reel rotatably mounted within the case and having a hub, the supply and the take-up reels being rotatably coupled such that a rotation of one of the reels drives a rotation of the other reel;
a drive device comprising one or more gears and configured to rotate at least one of the supply and the take-up reels to unwind or rewind a belt thereon, wherein the belt is capable of carrying a plurality of adhesive fabrics or tapes on a first face thereof; and
an activation device configured to slide along an outside surface of the case to advance a portion of one of the plurality of adhesive fabrics or tapes out of the opening;
wherein the dispenser is configured to extend the belt from the hub of the supply reel to a separation point at or beyond the opening and thence to the hub of the take-up reel, whereby each adhesive fabric can be separated from the belt as the belt advances to frictionally pass the separation point and beyond the opening from the supply reel toward the take-up reel;
wherein the case defines a second opening and a third opening, and the belt comprises first strip and a second strip, with the adhesive fabrics interposed there in between, wherein the dispenser is further configured to unwind the belt from the supply reel and extend through the first opening so that the first and second strips are split outside the first opening, and configured to channel back the first strip to the case through the second opening and wind the first strip onto the take-up reel and channel back second strip to the case through the third opening and wind the second strip onto the take-up reel.

US Pat. No. 10,478,356

SOFT, LIGHT-WEIGHT MALE URINE RECEPTACLE AND METHOD OF USE

15. The method of claim 14, further comprising the step of using a positioning member on the receptacle to position the receptacle on the penis, wherein the handle is at least one of a handle and ears.

US Pat. No. 10,478,354

ABSORBENT ARTICLE WITH A FLUID-ENTANGLED BODY FACING MATERIAL INCLUDING A PLURALITY OF HOLLOW PROJECTIONS

KIMBERLY-CLARK WORLDWIDE,...

1. An absorbent article comprising:an outer cover;
a body facing material; and
an absorbent body disposed between the outer cover and the body facing material,
wherein the body facing material comprises a fluid-entangled laminate web comprising:
a first layer comprising a first plurality of fibers and having a first surface and an opposed second surface, wherein the first layer has a basis weight of between about 10 grams per square meter and about 40 grams per square meter;
a second layer comprising a second plurality of fibers and having an inner surface and an opposed outer surface, wherein portions of the second surface of the first layer are in contact with the inner surface of the second layer, wherein at least a portion of the first plurality of fibers or the second plurality of fibers are fluid-entangled with at least a portion of the other of the first plurality of fibers or the second plurality of fibers;
a plurality of hollow projections formed from at least a portion of the second plurality of fibers, the plurality of hollow projections extending from the outer surface of the second layer in a direction away from the first layer; and
a and area, wherein the plurality of hollow projections are surrounded by the land area.

US Pat. No. 10,478,352

LENGTH-TO-SIDE SILHOUETTES OF ADULT DISPOSABLE ABSORBENT ARTICLES AND ARRAYS

1. An array of packages comprising two or more different sizes of disposable absorbent articles, the array comprising:a first package comprising a first disposable absorbent article, the first absorbent article comprising a first topsheet, a first backsheet, a first absorbent core and a first pair of side seams, the first absorbent article being a first size and in a closed form;
a second package comprising a second disposable absorbent article, the second absorbent article comprising a second topsheet, a second backsheet, a second absorbent core and a second pair of side seams, the second absorbent article being a second size and in a closed form;
wherein the second size is larger than the first size;
wherein the second absorbent article has one or more of:
(a) a larger Relaxed Product Side Length (303) than the first absorbent article; and
(b) a larger Relaxed Product Length (300) than the first absorbent article;
wherein a Product Length-to-Side Silhouette of the second absorbent article is equal to or greater than a Product Length-to-Side Silhouette of the first absorbent article; and
wherein the first package and the second package are in the same array.

US Pat. No. 10,478,351

ABSORBENT INCONTINENCE ARTICLE AND METHOD WITH ADJUSTABLE ENGAGING PLACEMENT

1. A disposable absorbent article for use with underwear and incontinence, the absorbent article comprising a single-piece pocketless construction including an upper portion integral with the absorbent article, a lower portion, a top sheet, a back sheet, and a middle sheet comprising absorbent material between the top sheet and the back sheet within the upper portion and the lower portion of the article between the top and bottom sheets, the upper portion integral with the absorbent article structured to adjustably fold over a waistband of the underwear and therein restrict movement of the absorbent article with respect to the underwear, wherein the upper portion of the single-piece pocketless construction also includes the absorbent material that increases absorbency capacity of the article inside the underwear when reducing the absorbent article fold over the waistband, the upper portion folded over the waistband outside the underwear also includes the absorbent material, and wherein the absorbent article is structured to only cover a frontal action of a body.

US Pat. No. 10,478,349

BODY FLUID SENSOR PAD

1. A bed pad with a body fluid sensor comprising:a first absorbent layer;
a second absorbent layer;
wherein the first absorbent layer further comprises a first conductive thread having a first length and a first metal attachment means on a first end of said first conductive thread;
wherein the second absorbent layer further comprises a second conductive thread having a second length and a second metal attachment means on a first end of said second conductive thread;
wherein the first conductive thread and the second conductive thread are disposed on the first and second layers respectively such that said first and second conductive threads do not contact each other thereby forming an open circuit;
wherein the first and second metal attachment means provide a conductive platform configured to allow power to be supplied to the open circuit through the attachment means;
wherein the first and second conductive threads form an open circuit under dry conditions, and wherein said open circuit is completed in the presence of a moisture insult causing an alarm signal indicating the presence of said insult.

US Pat. No. 10,478,348

UNIT FOR FEEDING A COMPONENT OF A HYGIENE ABSORBENT ARTICLE PROVIDED WITH A LINEAR ELECTRIC MOTOR

GDM S.p.A., Bologna (IT)...

1. A feeding unit (1) for feeding components (2) of a hygiene absorbent articles; the feeding unit (1) comprises:a plurality of sucking-holding heads (4), each of which is designed to receive and hold a corresponding component (2);
a conveyor (5) to cyclically move each holding head (4) along an annular application path (P);
an input station (S1), which is arranged along the application path (P) and in which each holding head (4) receives a corresponding component (2), which is connected—without gaps—to a continuous web (3);
a cutting station (S3), which is arranged along the application path (P) downstream of the input station (S1) and is provided with a cutting device (23), which cuts the continuous web (3) crosswise, so as to separate the component (2) held by each holding head (4) from the remaining part of the continuous web (3); and
an output station (S2), which is arranged along the application path (P) downstream of the rotation station (S4) and in which each holding head (4) releases the component (2);
wherein the conveyor (5) comprises:
an annular guide (8), which is arranged in a fixed position along the application path (P);
a plurality of slides (9), each of which supports a corresponding holding head (4) and is coupled to the guide (8) so as to freely slide along the guide (8), and
a linear electric motor (10), which comprises a single stator (11), which is arranged in a fixed position along the guide (8), and a plurality of mobile sliders (12), each of which is electro-magnetically coupled to the same stator (11) so as to receive, from the same stator (11), a driving force and is rigidly connected to a corresponding slide (9).

US Pat. No. 10,478,340

OPTICAL SYSTEM FOR A LASER THERAPY INSTRUMENT

Carl Zeiss Meditec AG, J...

15. An optical system for a laser therapy instrument, suitable for laser surgery of a cornea and/or a crystalline lens of an eye, comprising:a femtosecond laser radiation source that emits therapeutic laser radiation;
an objective from which the therapeutic laser radiation exits and is directed and focussed on to or into the eye at a focus position;
at least two optical assemblies that vary the focus of the therapeutic laser radiation, with a focus variation range ?z of the at least two optical assemblies differing in size;
a changing device that inserts one of the at least two optical assemblies at a time into a therapeutic laser beam path;
a first optical assembly that covers a first focus variation range ?z1 extending over the axial extension of the cornea; and
a second optical assembly that covers a focus variation range ?z2 extending over the axial extension of the crystalline lens.

US Pat. No. 10,478,338

OPHTHALMOSURGICAL SYSTEM

Carl Zeiss Meditec AG, J...

1. An ophthalmosurgical system comprising:a console for accommodating an irrigation fluid vessel containing irrigation fluid;
a cassette insertable into said console and being configured for directing the irrigation fluid to a surgical instrument for an eye to be treated;
an irrigation fluid flow path from said irrigation fluid vessel to said cassette and to said surgical instrument;
a first fluid pump including: a first pump chamber having a first volume; a first drive chamber having a second volume; and,
a first elastic partition element separating said first drive chamber from said first pump chamber;
said first pump chamber communicating with said irrigation flow path so as to receive irrigation fluid therefrom;
a first drive fluid supply for supplying a first drive fluid to said first drive chamber on the basis of a predetermined pressure with which an elastic deformation of said first elastic partition element is achieved causing a reduction of said first volume and simultaneously an increase in said second volume;
a second fluid pump arranged parallel to said first fluid pump;
said second fluid pump including: a second pump chamber having a third volume; a second drive chamber having a fourth volume; and, a second elastic partition element separating said second drive chamber from said second pump chamber;
said second pump chamber communicating with said irrigation flow path so as to receive irrigation fluid therefrom;
a second drive fluid supply for supplying a second drive fluid to said second drive chamber on the basis of a predetermined pressure with which an elastic deformation of said second elastic partition element is achieved causing a reduction of said third volume and simultaneously an increase of said fourth volume;
said first volume or said third volume having a magnitude lying in a range of 1 to 25 cm3;
said first elastic partition element having an edge and being fixedly mounted with said edge thereof in said first fluid pump;
said second elastic partition element having an edge and being fixedly mounted with said edge thereof in said second fluid pump; and,
wherein said irrigation fluid is supplied from said first and second pump chambers simultaneously and at a first pressure (pIRR1) to said irrigation fluid flow path in a direction toward said surgical instrument.

US Pat. No. 10,478,336

SYSTEMS AND METHODS FOR TRANSVERSE PHACOEMULSIFICATION

1. A handpiece for phacoemulsification, comprising:a needle, wherein the needle has a distal end and a proximal end, wherein the distal end of the needle vibrates in at least a transverse direction and a longitudinal direction when power is applied to the handpiece; and
a horn, wherein the horn has a distal end and a proximal end, wherein the distal end of the horn engages the proximal end of the needle and one or more piezoelectric rings are coupled with the proximal end of the horn, wherein the proximal end of the horn has one or more notches distributed around an outer surface of the horn that move a center of mass of the horn offset from a central longitudinal axis of the horn;
wherein the power applied has a single effective operating frequency to vibrate the needle in the transverse and longitudinal directions;
wherein the one or more notches are configured to create a transverse node on a frequency spectrum and enable the distal end of the needle to vibrate in the transverse and longitudinal directions when the power is applied.

US Pat. No. 10,478,331

SYSTEM, METHODS AND APPARATUS FOR DELIVERING NERVE STIMULATION TO A PATIENT WITH PHYSICIAN OVERSIGHT

Scion NeuroStim, LLC, Ra...

1. A vestibular stimulation device comprising:an earpiece;
a thermoelectric device (TED) thermally coupled to said earpiece; and
a controller operatively connected to said TED, said controller comprising:
a prescription comprising a set of instructions for delivering one or more thermal waveforms to the vestibular system and/or the nervous system of a patient; and
a control module configured to activate said TED to deliver the prescribed thermal waveform(s), wherein the prescribed thermal waveform(s) are configured to treat Parkinson's disease in a subject in need of treatment thereof.

US Pat. No. 10,478,328

OSTOMY POUCH REPLACEMENT DEVICE

1. An ostomy adhesive skin barrier replacement system comprising:a wafer including adhesive on a first side thereof, and a wafer ring on a second side thereof, wherein said wafer ring includes an inner perimeter having a first diameter;
a collar stand member, said collar stand member having a first end and a second end and defining a longitudinal tubular opening between said first end and said second end for telescopically receiving a tubular object therethrough, wherein said first end of said collar stand member is circular in shape, and said outer perimeter of said first end has a second diameter that is smaller than said first diameter, so that said first end of said collar stand member fits within an inner portion of said wafer ring for applying pressure to said wafer within said wafer ring in order to adhere said wafer to skin surrounding a stoma; and
wherein said collar stand may be placed in an upright manner on a flat horizontal surface so that said tubular opening, between said first end and said second end, is in a generally vertical orientation.

US Pat. No. 10,478,327

POSTURAL RECOVERY GARMENT DEVICE SYSTEM

IFGCURE HOLDINGS, LLC, L...

1. A wearable garment device for correcting a wearer's posture, the garment device comprising:a mesh anterior portion;
a mesh posterior portion;
a bottom edge defined along a bottom of said mesh anterior and mesh posterior portions;
said mesh anterior portion connected to said mesh posterior portion along first and second vertical seams;
a right sleeve;
a left sleeve;
said right sleeve connected to said mesh anterior portion and said mesh posterior portion along a right sleeve seam;
said left sleeve connected to said mesh anterior portion and said mesh posterior portion along a left sleeve seam; and
a single elastic strap extending horizontally from a lower portion of said right sleeve seam to a lower portion of said left sleeve seam along said mesh posterior portion and parallel to said bottom edge of the wearable garment device,
wherein, in use, said elastic strap is configured to extend along two scapulae of a wearer and across an upper posterior portion of the wearer's torso, and wherein said strap is configured to correct the wearer's posture by pulling the scapulae into postural alignment.

US Pat. No. 10,478,326

DEVICES AND METHODS FACILITATING SLEEVE GASTRECTOMY PROCEDURES

Covidien LP, Mansfield, ...

1. A method of performing a sleeve gastrectomy in the stomach, comprising:inserting a tubular guide through the esophagus and into the stomach;
extending an engaging member outwardly from the tubular guide against the greater curvature of the stomach;
illuminating at least a portion of the engaging member;
retracting the engaging member; and
resecting the stomach using a surgical stapler, forming a sleeve shaped portion of the stomach, and removing a remainder of the stomach.

US Pat. No. 10,478,323

BIODEGRADABLE STENT AND SHAPE MEMORY EXPANDING METHOD THEREFOR

SUNTECH CO., LTD., Seoul...

1. A shape memory extending method of a biodegradable stent, comprising:providing a stent made of a biodegradable polymer on an external surface of a balloon of a first balloon catheter;
extending an outer diameter of the stent by applying a first pressure to the balloon of the first balloon catheter to produce a stent with an extended outer diameter;
providing the stent with the extended outer diameter on an external surface of a balloon of a second balloon catheter; and
reducing the extended outer diameter of the stent, by crimping the stent while applying a second pressure to the balloon of the second balloon catheter;
wherein the step of extending the outer diameter of the stent is conducted at a temperature range of 55 to 180° C.; and
wherein the second balloon catheter is provided in crimping equipment.

US Pat. No. 10,478,321

VASCULAR IMPLANT WITH SIDE BRANCH

JOTEC GmbH, Hechingen (D...

1. A vascular implant for implanting into a blood vessel of a patient, the vascular implant being transformable from a compressed state into a self-expanded state, the vascular implant comprising:a hollow-cylindrical main body with a proximal end and a distal end, the hollow-cylindrical main body defining a main body lumen and a longitudinal axis;
at least one hollow-cylindrical side body that branches off from the main body and comprises a side body lumen and a side body implant material, the side body lumen being in fluidic connection with the main body lumen;
a plurality of stent springs successively arranged over the longitudinal axis of the main body, the plurality of stent springs including a first stent spring, a second stent spring, and a protruding stent spring;
an implant material fixed to the plurality of stent springs and connecting them, the stent springs being connected to one another via the implant material only and not connected by any other means between adjacent springs,
wherein the first stent spring, the second stent spring, and the protruding stent spring each have a plurality of legs and pointed arches, the pointed arches being defined by respective adjacent legs and a vertex or depression between the respective adjacent legs such that the pointed arches of the first and the second stent springs alternately face toward the proximal end and the distal end of the main body and parallel to the longitudinal axis thereof,
wherein at least three consecutive legs of each of the first stent spring, the second stent spring, and the protruding stent spring have different lengths, the at least three consecutive legs connecting a first vertex, a first depression following the first vertex in a circumferential direction, a second vertex following the first depression in the circumferential direction, and a second depression following the second vertex in the circumferential direction,
wherein respective vertices of the first stent spring are aligned circumferentially with respective depressions of the second stent spring and respective depressions of the first stent spring are aligned circumferentially with respective vertices of the second stent spring,
wherein the first stent spring, the second stent spring, and the protruding stent spring have an asymmetrical shape in which successive vertices have different heights in the proximal direction along the longitudinal axis and successive depressions have different depths in the distal direction along the longitudinal axis,
wherein the vertices of the first stent spring, the second stent spring, and the protruding stent spring include at least one maximum-height vertex that has a maximum height of respective vertices and the depressions of the first stent spring, the second stent spring, and the protruding stent spring include at least one maximum-depth depression that has a maximum depth of respective depressions,
wherein, in the self-expanded state, the at least one side body branching off from the main body is set up at an angle in relation to the longitudinal axis of the main body, the angle being defined by at least one pointed arch of the protruding stent spring of the main body, the at least one pointed arch angularly protruding in a preformed way in relation to the longitudinal axis of the main body in the self-expanded state, and
wherein the at least one pointed arch is formed by one of the at least one maximum-depth depressions of the protruding stent spring.

US Pat. No. 10,478,319

SYSTEM WITH TOOL ASSEMBLY AND EXPANDABLE SPINAL IMPLANT

Moskowitz Family LLC, Ro...

1. A system comprising:a tool assembly which comprises:
a first tool having a first proximal end and a first distal end with a first handle and a gripper, the gripper being positioned at the first distal end, cooperating with the first handle, and having first and second engagement prongs positioned at the first distal end, wherein the first tool defines an adjusting tool passage through the first tool; and
a second adjusting tool having a second proximal end and a second distal end with a second handle positioned at the second proximal end, a screw engagement portion positioned at the second distal end, and a shaft extending from the second handle to the screw engagement portion, wherein the shaft of the second adjusting tool is sized with a smaller diameter than that of the adjusting tool passage such that the second adjusting tool can extend through the adjusting tool passage of the first tool; and
an expandable spinal implant sized and configured to be implanted in a human spine, the expandable spinal implant comprising a first expandable spinal implant structure, a second expandable spinal implant structure, and an adjusting screw having a screw head and a threaded portion, wherein the expandable spinal implant is configured to expand the first expandable spinal implant structure with respect to the second expandable spinal implant structure in response to turning of the adjusting screw, wherein the expandable spinal implant defines first and second tool engagement indentations sized and configured for receiving the first and second engagement prongs of the first tool, wherein the adjusting screw is positioned within the expandable spinal implant in a screw location such that the second adjusting tool can extend through the adjusting tool passage of the first tool to engage the screw head of the adjusting screw while the first and second engagement prongs of the first tool are engaged with the first and second tool engagement indentations of the expandable spinal implant.

US Pat. No. 10,478,318

PROSTHESIS INSTALLATION SYSTEMS AND METHODS

Kambiz Behzadi, Pleasant...

1. An apparatus, comprising:a prosthetic tool;
a set of sensors mechanically coupled to said prosthetic tool, said set of sensors including one or more structures selected from the group consisting essentially of one or more accelerometers, one or more gyro meters, one or more magnetic sensors, and combinations thereof; and
a damper coupling said tool to said set of sensors wherein said prosthetic tool includes a housing, further comprising:
an alignment system mechanically coupled to said housing, wherein said alignment system incudes said set of sensors and a feedback system configured to provide an alignment variation indication during operation wherein said prosthetic tool includes a mounting system securing a prosthesis and wherein said housing contains an oscillation motor configured to vibrate said mounting system with a predetermined vibration profile.

US Pat. No. 10,478,316

DISCHARGE DEVICE FOR BONE REPLACEMENT MATERIALS

Sulzer Mixpac AG, Haag (...

1. A discharge device for discharging a mass, comprising:a housing having a peripheral housing wall, an open proximal housing end, and an open distal housing end, wherein a lateral cutout is formed in the housing wall;a piston; anda container insert, which is situated in the housing and comprises a peripheral container wall, an open proximal container end, and a distal container end, wherein a lateral container opening is formed in the container wall, and wherein the container insert can be rotated about a longitudinal axis relative to the housing between a closed position, in which the housing wall closes the lateral container opening, and a release position, in which the lateral cutout releases the lateral container opening,
wherein the lateral container opening extends continuously in an axial direction up to the distal container end without a region of the container wall adjoining the lateral container opening in a distal direction along the longitudinal axis, and
wherein the piston is displaceable in the container insert along the longitudinal axis.

US Pat. No. 10,478,312

IMPLANT WITH PROTECTED FUSION ZONES

Institute for Musculoskel...

1. An implant, comprising:a body including a base portion and a keel portion;
the keel portion oriented at a nonzero angle to the base portion;
a bone contacting outer member having an elongate geometry, the outer member including a first outer member end and a second outer member end;
a support member having an elongate geometry, the support member including a first support member end and a second support member end;
wherein the first outer member end is attached to the base portion and the second outer member end is attached to the keel portion;
wherein the first support member end is attached to the base portion and wherein the second support member end is attached to the base portion;
wherein the support member is attached to the outer member;
wherein the outer member has a central member curve; and
wherein the central member curve includes a winding segment, and wherein the winding segment of the central member curve winds around a fixed path.

US Pat. No. 10,478,310

VERTEBRAL IMPLANT, DEVICE FOR VERTEBRAL ATTACHMENT OF THE IMPLANT AND INSTRUMENTATION FOR IMPLANTATION THEREOF

LDR Medical, S.A.S., Sai...

1. A spinal segment replacement implant having a vertical axis and comprising:a first body having a spinal segment face configured compatibly with a first surface of a spinal segment;
a second body;
a third body having a spinal segment face configured compatibly with a second surface of a spinal segment;
a second body contact face disposed on the first body;
a second body contact face disposed on the third body;
a first body contact face disposed on the second body and configured to fit compatibly with the second body contact face disposed on the first body;
a third body contact face disposed on the second body and configured to fit compatibly with the second body contact face disposed on the third body;
a first abutment oriented obliquely to the sliding axis and disposed on one of the first body or the second body, and a first lock disposed with the other of the first body or the second body, the first lock comprising a first abutment engagement portion and an elastic portion articulating the first abutment engagement portion between an open position configured to permit sliding assembly of the first body with the second body along the sliding axis and a closed position configured to retain the first body in assembly with the second body;
a second abutment oriented obliquely to the sliding axis and disposed on one of the second body or the third body, and a second lock disposed with the other of the second body or the third body, the second lock comprising a second abutment engagement portion and an elastic portion articulating the second abutment engagement portion between an open position configured to permit sliding assembly of the second body with the third body along the sliding axis and a closed position configured to retain the second body in assembly with the third body;
interfitting retainers disposed along the first body contact face and the second body contact face disposed on the first body and configured for sliding assembly of the first body with the second body along a sliding axis oblique to the vertical axis and extending from a trailing end of the sliding axis to an insertion end of the sliding axis, and interfitting retainers disposed along the third body contact face and the second body contact face disposed on the third body and configured for sliding assembly of the second body with the third body along the sliding axis, the interfitting retainers comprising mating abutment faces configured to limit sliding of the second body along the sliding axis in the direction of the insertion end of the sliding axis;
an anchor comprising a penetration end configured for penetration of the first surface of a spinal segment, a driving end configured for impacting the anchor into the first surface of a spinal segment, a longitudinal axis extending between the penetration end and the driving end, and an anchor abutment disposed between the penetration end and the driving end and oriented angularly to the longitudinal axis;
an access surface on the first body at the trailing end of the sliding axis;
a passage extending from the access surface to the spinal segment face disposed on the first body, the passage defining an insertion access for the anchor; and
an anchor lock comprising
an anchor abutment engagement portion disposable along the passage and orientable angularly to the insertion axis, the anchor abutment engagement portion configured to operatively mate with the anchor abutment, and
a flexible portion having a resting position defining a first anchor abutment engagement portion position in which the anchor abutment engagement portion is extendable into the passage and engagable with the anchor abutment, and a second anchor abutment engagement portion position in which the anchor abutment engagement portion is retracted from the passage to permit passage of the anchor through the passage past the lock.

US Pat. No. 10,478,308

ELLIPSOIDALLY-SHAPED HUMERUS HEAD PROSTHESIS

1. A humerus head implant comprising:a head cap and a fixing component,
the head cap having a body enclosed between (i) an outer curved articulating surface that defines a half-ellipsoidal shape of the head cap and (ii) an inner surface that defines a conical recess in the body and that includes an extension surface surrounding said conical recess,
wherein, when a local coordinate system is chosen such that a z-axis is transverse to and directed from the extension surface to the outer curved articulating surface and an x-axis and a y-axis are in a plane of the extension surface:
a) an intersection of the z-axis with the outer curved surface represents a center of the outer curved articulating surface that, in operation of the implant, is aligned along the z-axis with a first point chose to represent a center of humerus, and
b) a center axis of the conical recess is transverse to the extension surface and is displaced along the y-axis from the z-axis such that the body is asymmetric with respect to the z-axis
and
wherein a ratio of an x-extent of the head cap along the x-axis to a y-extent of the cap along the y-axis is in a range from 0.8 to 0.95,
the fixing component comprising:
a conical section dimensioned to fit into the conical recess and to allow for rotation of the head cap relative to the fixing component, and
a bone-screw component.

US Pat. No. 10,478,305

STEERABLE LESION EXCLUDING HEART IMPLANTS FOR CONGESTIVE HEART FAILURE

BioVentrix, Inc., San Ra...

1. A method for treating a heart, the heart having a first chamber bordered by a septum and a wall, wherein the chamber comprises a left ventricle of the heart, the heart having a second chamber separated from the first chamber by the septum, the method comprising:providing a perforation device having a distal tip that is configured to deliver electrosurgical energy to heart tissue to enable the perforation device to penetrate through the heart tissue;
penetrating, via the perforation device, the septum at a first location selected for deployment of an implant;
penetrating, via the perforation device, the wall at a second location selected for the deployment of the implant;
controllably steering the perforation device between the first location and the second location; and
deploying the implant by affixing a first anchor of the implant adjacent the penetration of the septum, affixing a second anchor of the implant adjacent the penetration of the wall, and applying tension between the first anchor and the second anchor;
wherein the tensioned members are tensioned sufficiently to bring the wall and septum into engagement, and thereby effectively exclude a region of the wall and septum from the left ventricle with scar tissue extending along the excluded region.

US Pat. No. 10,478,303

DEVICE, SYSTEM, AND METHOD FOR TRANSCATHETER TREATMENT OF VALVULAR REGURGITATION

Polares Medical Inc., Pa...

1. A coaptation assistance element for treating mal-coaptation of a heart valve of a heart, the coaptation assistance element comprising:a first surface and an opposed second surface;
a first lateral edge, a second lateral edge, an inferior edge, and a superior edge; and
a superior zone and an inferior zone, the superior zone configured to reside in the plane of an annulus of the heart valve, the inferior zone extending downward from the superior zone,
wherein the inferior zone comprises a leaflet configured to move relative to the inferior edge such that a distance between the leaflet and the inferior edge is configured to increase during systole and configured to decrease during diastole.

US Pat. No. 10,478,301

CONVERTIBLE ANNULOPLASTY RING CONFIGURED TO RECEIVE AN EXPANDABLE PROSTHETIC HEART VALVE

Edwards Lifesciences Corp...

1. An annuloplasty ring, comprising:an annuloplasty support frame consisting of a single contiguous segment defining a circumferential shape surrounding a ring opening as seen when view from above, wherein the annuloplasty support frame is configured to transition from a first configuration to a second configuration only upon being subjected to a radially expansive force in vivo of at least 2 atm, and wherein in the first configuration the ring opening is “D”-shaped and in the second configuration the ring opening is more circular than the “D-shaped” first configuration, and wherein the annuloplasty support frame remains in the first configuration prior to being subjected to the radially expansive force and a transition from the first configuration to the second configuration occurs suddenly.

US Pat. No. 10,478,299

LOW CROSSING PROFILE DELIVERY CATHETER FOR CARDIOVASCULAR PROSTHETIC IMPLANT

DFM, LLC, Incline Villag...

1. A method of deploying a cardiovascular prosthetic implant, the method comprising the steps of:translumenally advancing a catheter having a distal portion with a diameter of 18 French and carrying a cardiovascular prosthetic implant with a tissue valve having a thickness of at least about 0.011 inches to a position proximate a native valve of a patient, wherein the cardiovascular prosthetic implant comprises an inflatable cuff, a tissue valve coupled to the inflatable cuff;
inflating the inflatable cuff fully with a hardenable inflation media; and
removing the catheter from the patient, leaving the hardenable inflation media in the cardiovascular prosthetic implant within the patient.

US Pat. No. 10,478,297

DELIVERY SYSTEM HAVING AN INTEGRAL CENTERING MECHANISM FOR POSITIONING A VALVE PROSTHESIS IN SITU

Medtronic Vascular, Inc.,...

1. A delivery system for a valve prosthesis configured for delivery within a vasculature, the delivery system comprising:an outer shaft defining a lumen and at least two windows formed through a sidewall thereof;
an inner shaft concentrically disposed within the lumen of the outer shaft, the inner shaft having a distal portion being configured to receive the valve prosthesis thereon; and
at least one centering mechanism including at least two wings disposed at circumferentially spaced-apart locations along the delivery system, a first end of each wing being attached to the inner shaft and a second end being free to slide over the inner shaft, wherein when the centering mechanism is in a delivery configuration each wing is circumferentially offset from one of the windows of the outer shaft and has a straightened profile that is enclosed between the outer and inner shafts and when the centering mechanism is in an expanded configuration each wing has a curved, bowed profile and is aligned with and radially extends through one of the windows of the outer shaft,
wherein the outer shaft is rotated in order to alternate the centering mechanism between the delivery configuration and the expanded configuration.

US Pat. No. 10,478,292

PROSTHETIC HEART VALVE

Edwards Lifesciences Corp...

1. An assembly comprising:a delivery catheter comprising an inflatable balloon; and
an implantable prosthetic heart valve that is radially collapsible to a collapsed configuration for delivery into a patient on the delivery catheter and radially expandable to an expanded configuration using the inflatable balloon;
the prosthetic heart valve comprising:
a radially expandable annular frame having an inflow end portion defining an inflow end of the frame that is configured to receive antegrade blood flow into the prosthetic heart valve when implanted within a patient's body in the expanded configuration, and the annular frame also having an outflow end portion defining an outflow end of the frame opposite the inflow end of the frame;
a leaflet structure positioned within the frame; and
an outer skirt extending from the inflow end of the frame along an outer surface of the frame to an outflow edge of the outer skirt, wherein the outflow edge of the outer skirt defines a plurality of alternating projections and notches of the outer skirt, the projections projecting further toward the outflow end of the frame relative to the notches, and wherein the outflow edge is attached to the frame at the projections and the outflow edge is free from the frame at the notches.

US Pat. No. 10,478,291

HEART VALVE PROSTHESIS AND METHODS OF MANUFACTURE AND USE

Medtronic CV Luxembourg S...

1. A valve prosthesis comprising:a valve body comprising a plurality of leaflets affixed to a skirt, adjoining leaflets affixed together to form commissures; and
a self-expanding frame comprising an inflow section having a first row of cells in a circumferentially repeating pattern defining an inflow edge of the frame, and an outflow section having a second row of cells in a circumferentially repeating pattern and including a plurality of eyelets;
wherein the area of individual cells in the first row of cells is less than the area of individual cells in the second row of cells;
wherein the frame has a contracted delivery configuration and an expanded deployed configuration, wherein, when the frame is in the expanded deployed configuration, the outflow section diameter is larger than the inflow section diameter;
wherein the frame supports the valve body, wherein a portion of the skirt is folded over the inflow edge of the frame and affixed to the first row of cells and the commissures are sewn to the frame between the first and second rows of cells.

US Pat. No. 10,478,290

EXPANDABLE STENT VALVE

1. A device for implantation at a position of a heart, the device comprising:a valve frame defining a lumen, the valve frame having an upstream end and a downstream end;
a plurality of valve leaflets attached to and disposed within the valve frame;
a sewing member surrounding the valve frame at a region between the upstream end and the downstream end, for forming an attachment to tissue at the position of the heart; and
a membrane disposed about the valve frame for obstructing fluid flow between the lumen and an external region surrounding the valve frame,
wherein the valve frame is expandable, and a portion of the membrane at a side region of the downstream end of the valve frame comprises an opening that permits fluid flow through the side region.

US Pat. No. 10,478,289

REPLACEMENT VALVE AND ANCHOR

BOSTON SCIENTIFIC SCIMED,...

1. An implantable prosthetic heart valve, comprising:a stent having a distal inflow region defining a distal end of the stent and a distalmost inflow outer diameter, a central region having a central outer diameter, and a proximal outflow region defining a proximal end of the stent and a proximalmost outflow outer diameter; and
a plurality of leaflets coupled to the stent;
wherein the proximalmost outflow outer diameter is greater than the central outer diameter;
wherein the proximalmost outflow outer diameter is greater than the distalmost inflow outer diameter; and
wherein the distalmost inflow outer diameter is greater than the central outer diameter.

US Pat. No. 10,478,288

TRILEAFLET MECHANICAL PROSTHETIC HEART VALVE

Clover Life Sciences Inc....

1. A trileaflet mechanical prosthetic heart valve comprising:a ring including three or more protrusions located along an inner circumference of the ring;
three or more hinges attached to the ring, the three or more hinges evenly spaced from one another along the inner circumference of the ring; and
three or more leaflets, each leaflet attached to one of the three or more hinges, each leaflet attached to a hinge by an opening located in a center of a lower portion of the leaflet, each leaflet including:
a front surface having a concave shape in a transverse axis and a flat shape in a longitudinal axis,
a rear surface having a convex shape in the transverse axis and a flat shape in the longitudinal axis, the rear surface of the leaflets configured to be in contact with the protrusions of the ring when the leaflets are in an open position such that there is an arc shaped gap formed between the rear surface of the leaflets and the inner circumference of the ring when the leaflets are in the open position, wherein the the rear surface of the leaflets substantially tracks the inner circumference of the ring when the leaflets are in the open position; and
flat regions on left and right sides of the front surface of the leaflets, the flat regions for improved fluid dynamics.

US Pat. No. 10,478,287

SPEAKING VALVE WITH COVER PART, COMPRISING A CLOSURE PART WITH A RISING CENTRAL PART

1. A speaking valve for laryngectomized or tracheostomized patients, the speaking valve comprising: a cover part, a housing part, and a filter disposed in the housing part, wherein the cover part includes a closure part disposed on an inner surface thereof, facing toward the filter, wherein the cover part also includes an elastic material, wherein the closure part closes the speaking valve at an end distal to the filter by deformation of at least one region of the cover part, wherein the closure part has a circular design with a lowermost outer edge, an ascending middle part continuously rising from the lower most outer edge portion to a highest most inner attachment projection extending from the cover part and arranged at a central axis of the housing part.

US Pat. No. 10,478,285

DUAL OPTIC, CURVATURE CHANGING ACCOMMODATIVE IOL

Novartis AG, Basel (CH)

1. An intraocular lens configured to be implanted within a capsular bag of a patient's eye, the lens comprising:a fluid optic body comprising a cavity for containing an optical fluid, the cavity defined by:
a deformable optical membrane configured to extend across an optical axis of the patient's eye, the deformable optical membrane defining an anterior surface of the cavity;
a second optical membrane configured to extend across the optical axis of the patient's eye, the second optical membrane defining a posterior surface of the cavity; and
a sidewall having an anterior end connected to the deformable optical membrane and a posterior end connected to the second optical membrane such that the sidewall extends between the deformable optical membrane and the second optical membrane;
a second optic body spaced a distance apart from the fluid optic body and configured to extend across the optical axis of the patient's eye; and
a plurality of struts extending from the sidewall and coupling the fluid optic body to the second optic body, the struts being configured such that axial compression of the capsular bag causes the plurality of struts to rotate the sidewall about a pivot in a manner that increases a diameter of the cavity at the anterior end of the sidewall more than a diameter of the cavity at the posterior end of the sidewall such that a radius of curvature of the deformable optical membrane is increased.

US Pat. No. 10,478,284

METHODS FOR TISSUE PASSIVATION

The General Hospital Corp...

1. A method of preventing or decreasing intimal hyperplasia within a human blood vessel, the method comprising exposing an intact, non-proliferative, exterior surface of the human blood vessel to a cross-linking tissue structure stabilizing agent (“TSSA”) that does not penetrate beyond an external layer of collagen in the exterior surface under conditions sufficient to promote cross-linking of proteins within the exterior vascular surface while preserving normal tissue architecture of regions of the human blood vessel beyond the external layer of collagen, thereby preventing or decreasing intimal hyperplasia within the human blood vessel.

US Pat. No. 10,478,281

IMPLANTABLE PROSTHESIS FOR SOFT TISSUE REPAIR

C.R. Bard, Inc., Murray ...

1. An implantable prosthesis for mending a groin hernia, the implantable prosthesis comprising:a patch of repair fabric including a medial portion, a lateral portion, a lateral end and a transition region, the medial portion configured to be positioned at a first tissue plane, the lateral portion configured to be positioned at a second tissue plane offset from the first tissue plane, the transition region configured to be positioned through an opening in tissue and/or muscle separating the first and second tissue planes; and
a support member located along the medial portion, the lateral portion and the transition region to help deploy and/or hold the patch in a spread out configuration, the support member including a transition segment associated with the transition region of the patch, the transition segment being located from at least 2.5 cm to at least 5.1 cm from the lateral end of the patch and having an outer width that does not exceed 4.2 cm.

US Pat. No. 10,478,276

PELLET DELIVERY MECHANISM

World Wildlife Fund, Inc....

1. A pellet delivery apparatus, comprising:a loading assembly configured for arranging a plurality of pellets into one or more loading queues; and
a projector assembly coupled to the loading assembly, the projector assembly configured for receiving one or more pellets from the one or more loading queues;
wherein the projector assembly is further configured for periodically ejecting at least one pellet at a time in accordance with a predetermined pellet distribution plan.

US Pat. No. 10,478,275

MEDICAL DIAGNOSTIC APPARATUS HAVING HEIGHT-ADJUSTABLE TABLE FOR ANIMALS

1. A medical diagnostic apparatus having a height-adjustable table for animals, the apparatus comprising:a table where an animal is placed;
a support stand supporting the table such that the table vertically moves and adjusting height of the table to move the table close to a floor;
an X-ray detector disposed under the table and coupled to the support stand to move with the table;
an imaging stand spaced from the table, connected to the support stand, and having an X-ray tube for radiating X-rays to the X-ray detector; and
an imaging stand support coupled to the support stand and supporting the imaging stand such that the imaging stand moves left and right,
wherein the imaging stand support comprises:
a support frame coupled to the support stand and having a first lateral guide rail disposed in a width direction of the table;
a lateral moving block supporting the imaging stand, having a plurality of rollers disposed on the first lateral guide rail, and disposed on the support frame to move left and right in a width direction of the support frame;
a second lateral guide rail spaced from the first lateral guide rail and disposed on an inner side of the support frame; and
a guide block coupled to the lateral moving block and having second rollers moving on the second lateral guide block, and
wherein a distance between a side X-ray detector and the X-ray tube is adjusted by moving the imaging stand left and right in order to take X-ray images of a side of an animal.

US Pat. No. 10,478,274

POWERED TOOTHBRUSH HEAD HAVING COMBINATION OSCILLATING MOTION TUFT BLOCK

Colgate-Palmolive Company...

1. A method for oscillating a first movable tuft block of a powered toothbrush in a brushing action, the method comprising:(a) providing a powered toothbrush having a head portion comprising a vertical axis and including a rotatable drive shaft driven by a motor, the head portion including a first movable tuft block operably coupled to the drive shaft and movable in an oscillation cycle through a bottom vertical position and a top vertical position;
(b) placing the first movable tuft block in the bottom vertical position with the first movable tuft block in an upright orientation wherein a top surface of the tuft block faces upwards;
(c) rotating the drive shaft;
(d) pivoting the first movable tuft block outwards away from the vertical axis in a first lateral direction and into a first tilted orientation wherein the top surface of the first movable tuft block faces outwards away from the vertical axis;
(e) vertically raising the first movable tuft block towards the top vertical position while at least partially maintaining the first tilted orientation;
(f) pivoting the first movable tuft block inwards back toward the vertical axis and into the top vertical position wherein the first movable tuft block resumes an upright orientation;
(g) pivoting the first movable tuft block outwards away from the vertical axis in a second lateral direction and into a second tilted orientation wherein the top surface of the first movable tuft block faces outwards away from the vertical axis;
(h) vertically lowering the first movable tuft block towards the bottom vertical position while at least partially maintaining the second tilted orientation; and
(i) pivoting the first movable tuft block inwards in the first lateral direction back towards the vertical axis and into the bottom vertical position wherein the first movable tuft block resumes an upright orientation, thereby completing one oscillation cycle of the first movable tuft block.

US Pat. No. 10,478,273

DENTAL DEVICE FOR AUTOMATICALLY CLEANING A PERSON'S ORAL CAVITY

1. A dental device for cleaning user's teeth, gums, tongue and roof of the mouth of the user, comprising a mouthpiece shaped to fit or approximate the user's mouth, and to fit in the user's mouth, said device including one or a pore vibratory elements for vibrating portions of the device relative to the user's teeth, and/or gums, and including one or more brushes driven by the one or more vibratory elements, wherein at least some of the brushes are located on an exterior wall of the mouthpiece and extend to clean the gums, tongue and roof of the mouth of the user when the device is in use.

US Pat. No. 10,478,269

METHOD FOR AUTOMATICALLY MOVING OBJECT IN SIMULATION SYSTEM AND SIMULATION SYSTEM USING THE SAME

DIRCO CO., LTD., Suwon-s...

1. A method for automatically moving an object in a simulation system, comprising:moving a first object of a plurality of objects using a user input unit from a first position to a second position in a first direction in accordance with a predetermined dental arch path, the plurality of objects being obtained from a dental arch image of a subject by a control unit and being three-dimensional (3D) objects;
measuring a vector distance between the first object and a second object which is adjacent to the first object based on an expected movement of the first object by a control unit;
based on the vector distance, automatically vector-moving the second object that is adjacent to the first object, in the simulation system, by a predetermined distance in the first direction along the predetermined dental arch path until the vector distance between the first object and the second object is in a preset vector distance range by the control unit, thereby resulting in automatic alignment of the plurality of objects with one another on the predetermined dental arch path,
automatically moving a third object which is an object adjacent to the second object so that the third object is in the preset vector distance range from the second object by the control unit according to the automatic movement of the second object,
extracting intersection points at which the plurality of 3D objects and a reference surface having a plane equation intersect with each other by the control unit,
converting the 3D objects into two-dimensional (2D) objects using the intersection points by the control unit, and
setting a 2D path which is determined using center points of the 2D objects to the present path by the control unit,
wherein the predetermined distance is smaller than the vector distance and
wherein the automatic vector-moving of the second object includes, based on the vector distance, determining whether the first object and the second object either overlap with or spaced apart from each other.

US Pat. No. 10,478,263

DISPLACEMENT CONTROL WIRE DEVICE AND METHOD

Northeast Scientific, Inc...

1. A surgical control wire comprising:a control wire configured to provide curvature to displace a section of the esophagus of a human away from the heart during surgery, said control wire being formed of a shape memory material, said control wire having a spring temper and a suitable diameter to provide deflection of said esophagus, said control wire including a first end portion that is constructed and arranged to contact a first inner side wall of said esophagus, said first end portion including a distal end, said distal end including a stabilizer member, said stabilizer member being rounded having a surface area greater than said control wire, said stabilizer member constructed and arranged to prevent said control wire from puncturing said first inner side wall, said control wire having a first straight section adjacent said stabilizer member, an operative portion including a first bend and a second straight section in said control wire, said first bend and said second straight section configured to be large enough to force displacement of an opposite side wall of said esophagus in an opposite direction with respect to said stabilizer member, an offset bend for directing said control wire back toward a longitudinal axis of said first straight section, a second bend sized so that a shaft portion of said control wire is substantially axially aligned with said first end portion of said control wire, and a second end portion having a handle member for manipulation of said control wire, whereby rotation of said control wire mechanically displaces said section of said esophagus in the area of said esophagus containing said bends in said control wire.

US Pat. No. 10,478,262

ORTHOPAEDIC INSTRUMENT SYSTEM INCLUDING AN INSTRUMENT CADDY AND METHOD FOR ASSEMBLING A SURGICAL INSTRUMENT

DePuy Ireland Unlimited C...

11. An orthopaedic instrument system, comprising:an instrument caddy configured to receive a cutting broach, the caddy comprising a bottom wall, a first side wall extending upwardly from the bottom wall, and a second side wall spaced apart from the first side wall and extending upwardly from the bottom wall to define a storage chamber,
wherein the first side wall includes an opening and a pair of surfaces extending inwardly from the opening to define a groove sized to receive a base of the cutting broach,
wherein a slot aligned with the groove extends through the second side wall, the slot being sized to receive a tip of the cutting broach.

US Pat. No. 10,478,260

ENCLOSURE FOR AN ACOUSTIC ENERGY DEVICE INCLUDING A PROBE

NEURAL ANALYTICS, INC., ...

1. An enclosure for an acoustic energy device to be used on a subject, the device including a probe supported by a housing, the housing defining a cavity through which the probe protrudes, and the probe configured to move within the cavity and directly contact the subject, the enclosure comprising:a removable enclosure body, wherein the enclosure body is configured to enclose at least a portion of the housing while covering the cavity; and
a probe interaction portion in the enclosure body, wherein the probe interaction portion defines a first hole configured to receive at least a portion of the probe such that the probe is configured to extend through the enclosure body via the first hole and directly contact the subject when the enclosure body covers the cavity.

US Pat. No. 10,478,249

CONTROLLED TISSUE ABLATION TECHNIQUES

PYTHAGORAS MEDICAL LTD., ...

1. Apparatus for use with tissue of a renal nerve passing longitudinally within a wall of a renal artery of a subject, the apparatus comprising:a catheter, configured to be placed within the renal artery;
one or more stimulating electrodes coupled to the catheter and configured to stimulate the tissue of the renal nerve by passing a stimulating current through the wall of the renal artery;
a sensor configured to sense blood pressure information of the subject; and
a control unit, configured to:
drive the one or more stimulating electrodes to stimulate the tissue of the renal nerve,
receive the blood pressure information from the sensor,
based on the received blood pressure information, compute a maximum intra-heartbeat blood pressure increase rate for at least one heartbeat that follows a start of the driving of the one or more stimulating electrodes to stimulate the tissue of the renal nerve,
compare the maximum intra-heartbeat blood pressure increase rate to a threshold, and
generate, in response to the comparison, an output indicating whether an ablation of the tissue of the renal nerve should be performed.

US Pat. No. 10,478,247

EXPANDABLE CATHETER AND RELATED METHODS OF MANUFACTURE AND USE

Boston Scientific Scimed,...

1. A medical device, comprising:an expandable energy delivery array reciprocally movable between a first configuration and a second configuration, the expandable energy delivery array comprising:
a first assembly having a unitary first proximal end piece, a unitary first distal end piece, and a plurality of first energy transfer elements each directly coupled to and extending between the unitary first proximal and unitary first distal end pieces; and
a second assembly having a unitary second proximal end piece, a unitary second distal end piece, and a plurality of second energy transfer elements each directly coupled to and extending between the unitary second proximal and unitary second distal end pieces, wherein the unitary second proximal end piece is proximal to the unitary first proximal end piece, and a proximalmost portion of the unitary second distal end piece is distal to a distalmost portion of the unitary first distal end piece, wherein the first and second energy transfer elements circumferentially alternate with one another relative to a longitudinal axis of the medical device such that each first energy transfer element is circumferentially between two second energy transfer elements, and each second energy transfer element is circumferentially between two first energy transfer elements;
wherein:
the first and second assemblies are electrically insulated from one another;
the first and second proximal end pieces are separated by a first insulating element contained longitudinally between the first and second proximal end pieces; and
the first and second distal end pieces are longitudinally separated by a second insulating element contained longitudinally between the first and second distal end pieces.

US Pat. No. 10,478,243

SURGICAL INSTRUMENTS AND METHODS FOR PERFORMING TONSILLECTOMY AND ADENOIDECTOMY PROCEDURES

COVIDIEN LP, Mansfield, ...

7. A method of surgery, comprising:grasping tissue between tissue-contacting surfaces of first and second jaw members of an end effector assembly, the tissue contacting surface of the second jaw member having a width that extends directly from a first outer edge of the second jaw member to a second outer edge of the second jaw member;
supplying energy to at least one of the tissue-contacting surfaces to treat the tissue that is grasped between the tissue-contacting surfaces of the first and second jaw members of the end effector assembly; and
cutting adjacent tissue disposed outside of an area defined between the tissue-contacting surfaces with a member extending from the first jaw member, wherein the member is fixed from movement relative to the tissue-contacting surface of the first jaw member, wherein grasping the tissue also affects cutting the adjacent tissue, and wherein supplying the energy is performed after grasping the tissue and after cutting the adjacent tissue.

US Pat. No. 10,478,233

ADJUSTABLE HOOK

Alphatec Spine, Inc., Ca...

1. A bone hook assembly adaptable to engage any one of a plurality of pedicle, lamina, or transverse process bones, each of the plurality of pedicle, lamina, or transverse process bones being dimensioned different than the other, the bone hook assembly comprising:a main body having a rod receiving portion;
a jaw spaced apart from the main body so as to define a slot for receiving one of the plurality of pedicle, lamina, or transverse process bones, wherein the slot has a height;
an actuator configured to adjust the height of the slot;
a pair of tabs on the jaw; and
a receiving portion having elongated slots;
wherein the actuator is configured to translate a rotation into an adjustment of the height of the slot; and
wherein the receiving portion is configured to slidingly receive the jaw wherein the pair of tabs are configured to slide into a respective elongated slot.

US Pat. No. 10,478,230

POLYAXIAL BONE SCREW WITH INCREASED ANGULATION

K2M, Inc., Leesburg, VA ...

1. A polyaxial bone screw device comprising:a screw including a screw head and a shaft extending from the screw head;
a screw housing defining a longitudinal axis and a bore that extends along the longitudinal axis, the screw housing including a basewall and opposed sidewalls that extend from the basewall, the basewall defining a notch configured to receive a portion of the shaft therein, the notch configured to increase pivotal movement between the screw and the screw housing relative to the longitudinal axis of the screw housing, the opposed sidewalls defining a rod-receiving channel, the screw housing further defining a transverse hole that is in communication with the bore;
a spring supported in the transverse hole of the screw housing and extending therethrough, the spring extending into the bore of the screw housing to frictionally engage the screw head of the screw while the screw head is seated in the bore of the screw housing; and
a pin disposed within the transverse hole and in engagement with the spring.

US Pat. No. 10,478,229

PIVOTAL BONE ANCHOR ASSEMBLY WITH BOTTOM LOADED INSERT AND PIVOTLESS RETAINER

Roger P. Jackson, Prairi...

1. A pivotal bone anchor assembly for securing an elongate rod to a bone, the pivotal bone anchor assembly comprising:a shank having an upper capture portion and an anchor portion extending distally from the upper capture portion for fixation to the bone;
a receiver having a top, a bottom, and a longitudinal axis extending from the top to the bottom, a base defining a chamber communicating with the bottom of the receiver through a bottom opening, and a first pair of upstanding arms extending upwardly from the base to define a first channel opening onto the top of the receiver and configured to receive the elongate rod, the first channel communicating with the chamber, the chamber having an upper cylindrically shaped expansion portion with a first diameter and a lower cylindrically shaped locking portion with a second diameter smaller than the first diameter, the locking portion further defined in part by an upwardly-facing seating surface extending perpendicular to the longitudinal axis;
an insert having a second pair of upstanding arms defining a second channel opening onto a top of the insert and configured to receive the elongate rod, the insert being uploaded into the receiver chamber through the bottom opening, the insert having an outer surface that is slidably engageable with a longitudinal alignment structure formed in the receiver to prevent rotation between the insert and the receiver and to maintain the second channel in alignment with the first channel; and
an open retainer ring having a top surface, a bottom surface, an internal surface, and an external surface, and having a gap extending entirely through the ring from the top surface to the bottom surface and from the internal surface to the external surface, the retainer ring being uploaded into the receiver chamber through the bottom opening after the insert and positionable within the receiver chamber,
wherein the shank upper capture portion is uploadable into the receiver chamber through the bottom opening after the insert and the retainer ring, in which the upward loading motion of the shank upper capture portion along the longitudinal axis urges the retainer ring into expansion within the upper cylindrically shaped expansion portion, after which the retainer ring resiliently returns to a non-expanded state within the lower cylindrically shaped locking portion so as to capture the shank upper capture portion within the receiver chamber, and
wherein the insert is configured to engage the shank upper capture portion, with the retainer ring being seated against the upwardly-facing seating surface, so as to lock the shank with respect to the receiver.

US Pat. No. 10,478,228

SCREW ASSEMBLY FOR SPINAL IMPLANT

1. A screw assembly for a spinal implant, comprising:a first unit including insertion holes positioned opposite each other, cut from an edge of an upper end of the first unit, the first unit forming an inner space, and the first unit penetrated from top to bottom, wherein the first unit further comprises:
a linear groove depressed in parallel with an upper portion of the first unit along an outer circumference surface of the first unit;
a first hole depressed into a preset depth and a preset size in the outer circumference surface of the first unit to be positioned in a lower portion of the first unit; and
second holes, having a rectangular shape, positioned between the linear groove and the first hole, and depressed from both edges of each of the insertion holes positioned opposite each other to be disposed along an outer surface of the first unit;
a rod having a side whose outer circumference surface is positioned on the insertion holes of the first unit and another side whose outer circumference surface is positioned on insertion holes of another first unit positioned adjacent to the first unit;
a second unit having an upper portion rotatably received in a lower portion of the inner space and a lower portion configured to be screwed into a vertebral body of a spine so s not to be released from the spine;
a third unit screwed to an upper portion of the inner space to hold the rod;
a fourth unit positioned between the inner space and the upper portion of the second unit to restrict a rotation of the second unit and including a pressure cap seated in the inner space while pressing an outer surface of an upper portion of a ball joint head disposed on the upper portion of the second unit and having an upper portion contacting the outer circumference surface of the rod to be pressurized by a coupling force of the third unit coupled with the first unit; and
a fifth unit enabling the pressure cap of the fourth unit to be inserted into the first unit and including a C-ring preventing the inserted pressure cap from escaping off.

US Pat. No. 10,478,227

ORTHOPEDIC FIXATION DEVICES AND METHODS OF INSTALLATION THEREOF

GLOBUS MEDICAL, INC., Au...

1. A modular tulip system for spine stabilization, said system comprising:a first tulip assembly comprising a first tulip element and a second tulip element separated from the first tulip element, wherein the first tulip element is configured to be received modularly over a first bone fastener, wherein the first tulip element comprises a first pair of arms defining a first channel and the second tulip element comprises a second pair of arms defining a second channel, wherein a bridge extends between the first pair of arms and the second pair of arms, wherein the first pair of arms and the second pair of arms are formed monolithically with the bridge;
a first locking cap assembly configured to be received in the first channel between the first pair of arms and a second locking cap assembly configured to be received in the second channel between the second pair of arms; and
a first rod member configured to be received in the first tulip assembly via the first tulip element,
wherein the first pair of arms and the second pair of arms are positioned in a vertical direction such that the first rod member can be downwardly deposited into the first pair of arms, and
wherein the first tulip element has an exposed opening for receiving a first bone fastener while the second tulip element of the first tulip assembly does not have an exposed opening for receiving a bone fastener.

US Pat. No. 10,478,226

POLYAXIAL BONE ANCHORING DEVICE

1. A polyaxial bone anchoring device comprising:a bone anchoring element having a shank to be anchored to a bone and a head;
a receiving part configured to pivotably receive the head, the receiving part having a first end, a second end, a central axis, and a channel at the first end for receiving a rod;
a pressure member positionable in the receiving part to exert pressure onto the head to clamp the head in the receiving part, the pressure member comprising a deformable portion; and
a locking member insertable into the channel to contact the pressure member;
wherein when the head, the pressure member, and the locking member are in the receiving part, the locking member is movable in the channel of the receiving part along the central axis from a first position wherein at least part of the bone anchoring element is configured to directly contact the receiving part while the locking member contacts and is restricted by the deformable portion of the pressure member from moving further axially towards the second end of the receiving part, to a second position that is closer to the second end of the receiving part than the first position wherein the head is clamped in the receiving part while the locking member contacts and deforms the deformable portion of the pressure member radially outwardly compared to the first position to permit further axial movement of the locking member towards the second end of the receiving part for the locking member to come into contact with the rod and clamp the rod.

US Pat. No. 10,478,224

DISTRACTION CLAMP FOR TREATING INJURIES

1. A distraction clamp for treating injuries, comprising:a rod clamp assembly having two clamps each configured to retain a rod,
a pin clamp assembly comprising a bracket having a first mating surface, and two retainers each having a second mating surface, said bracket structured to retain a plurality of pins,
a clamp connector interconnecting said rod clamp assembly to said pin clamp assembly,
said first and second mating surfaces of correspondingly disposed ones of said bracket and said two retainers disposed in movable, retaining engagement with one another,
said first and second mating surfaces each including a plurality of spaced apart parallel ribs cooperatively structured to collectively define an adjustable threaded engagement with one another,
a plurality of grooves and a plurality of pins respectively formed on said bracket and said retainers independently of said plurality of spaced apart parallel ribs, said plurality of grooves and said plurality of pins movably interconnected and cooperatively oriented to maintain a transverse movement of said bracket relative to said clamp connector and said rod clamp assembly, and
said bracket reciprocally movable along its length on and in transverse relation to said clamp connector and said rod clamp assembly.

US Pat. No. 10,478,220

MEDICAL INSTRUMENT FOR IMPLANTING PINS

1. A medical instrument for putting at least one rectilinear pin (2) of a determined length and a determined diameter (2) into place in a long bone (3), the medical instrument comprising:an insertion trocar (5) comprising a guide sheath (6) presenting a pointed distal end (6a) and a proximal grip end, a removable obturator (7) being slidably mounted inside the guide sheath from a proximal end thereof;
a guide (10) for the at least one rectilinear pin (2), the guide comprising a flexible tube (11) presenting an outside diameter less than an inside diameter of the guide sheath of the insertion trocar to enable the flexible tube to be inserted in the guide sheath from the proximal end thereof, after the removable obturator has been removed, the flexible tube (11) presenting between a distal end and a proximal end thereof a length that is greater than the determined length of the at least one rectilinear pin and an inside diameter that is greater than the determined diameter of the pin so as to leave operating clearance enabling the at least one rectilinear pin to move in translation inside the flexible tube; and
a positioner (13) for positioning the at least one rectilinear pin (2), the positioner comprising a positioner obturator (14) possessing an outside diameter less than the inside diameter of the flexible tube (11) in order to enable the positioner obturator to be inserted in and to slide inside the flexible tube, the positioner obturator (14) presenting a distal end (14a) forming a thrust surface for the at least one rectilinear pin (2) in order to position the distal end of the at least one rectilinear pin at the distal end of the flexible tube, the positioner obturator (14) externally defining a surface (14g) for the flexible tube (11) over a length not less than the length of the flexible tube.

US Pat. No. 10,478,219

SURGICAL ACCESS PORT

Applied Medical Resources...

1. A surgical access port to access a body cavity and sealingly engage a surgical instrument inserted therethrough, the surgical access port comprising:a trocar seal housing comprising:
an instrument seal configured to form a seal around the surgical instrument inserted through the surgical access port;
a zero seal configured to form a seal when no surgical instrument is present in the surgical access port;
a first slot and a second slot on opposing sides of the trocar seal housing;
a trocar cannula comprising a first cantilever arm and a second cantilever arm extending proximally therefrom;
a trocar lock releasably attaching the trocar seal housing to the trocar cannula, the trocar lock defined by the first cantilever arm and the second cantilever arm operationally engageable with the first slot and the second slot.

US Pat. No. 10,478,218

SCALPEL HOLDER

HELMUT ZEPF MEDIZINTECHNI...

1. A scalpel holder, having a grip piece with a longitudinal direction and a blade holder which is connected to the grip piece and which blade holder functions to receive a scalpel blade and hold the same fixed, wherein the grip piece has a slider guide running substantially in the longitudinal direction of the grip piece, wherein a slider received in said slider guide is movably guided in the slider guide, wherein the slider has a slider rod and a push rod connected to each other in a fixed manner, and the push rod furthermore has an end piece with a wedge-shaped design for the purpose of allowing a person using only one hand to engage the push rod, thereby lifting out a scalpel blade fastened on the blade holder, wherein the slider guide is arranged on the grip piece in such a manner that the end piece of the slider guided in the slider guide in the direction of the blade holder slides past the scalpel blade while lifting the scalpel blade out of the blade holder, and wherein the push rod is divided in cross-section into two components, a first component comprising a shoulder edge region, and a second component comprising the wedge-shaped end piece extending longitudinally beyond the first component, for the purpose of laterally lifting the scalpel blade away from the blade holder while simultaneously pushing the scalpel blade longitudinally away from the blade holder.

US Pat. No. 10,478,217

ATHERECTOMY DEVICES AND METHODS

Cardio Flow, Inc., St. P...

1. A rotational atherectomy device for removing stenotic lesion material from a blood vessel of a patient the device comprising:an elongate flexible drive shaft comprising helically wound metallic filars that form a coil having an outer diameter, the drive shaft defining a longitudinal axis;
an array of at least two spherical eccentric abrasive elements being fixed to the drive shaft such that a center of mass of each abrasive element is offset from the longitudinal axis; and
a metallic stability element having a cylindrical shape and a center of mass aligned with the longitudinal axis; and
wherein the drive shaft, the abrasive elements, and the metallic stability element rotate together about the longitudinal axis,
wherein the metallic stability element being distally spaced apart from a distal-most abrasive element of the spherical eccentric abrasive elements by a distal separation distance,
wherein each abrasive element is spaced apart from an adjacent abrasive element by an element spacing distance, and wherein the center of mass for each eccentric spherical abrasive element in said array is offset from the longitudinal axis while contemporaneously the center of mass of the metallic stability element is aligned with the longitudinal axis, and
wherein the distal separation distance being greater than the element spacing distance.

US Pat. No. 10,478,213

TISSUE-REMOVING CATHETER WITH ADJUSTABLE CROSS-SECTIONAL DIMENSION

Covidien LP, Mansfield, ...

1. A medical device comprising:a tissue-removing catheter comprising:
a drive shaft having opposite proximal and distal ends and configured for rotation about a longitudinal axis;
a tissue-removing head at the distal end of the drive shaft, wherein the tissue-removing head is configured to rotate about the longitudinal axis, and wherein the tissue-removing head is selectively adjustable from an initial cross-sectional dimension to an expanded cross-sectional dimension larger than the initial cross-sectional dimension; and
an expansion mechanism configured to selectively adjust the tissue-removing head from the initial cross-sectional dimension to the expanded cross-sectional dimension, wherein the expansion mechanism includes an elastically deformable member disposed inside the tissue-removing head, wherein the elastically deformable member is selectively elastically compressible in a longitudinal direction to increase a cross-sectional dimension of the elastically deformable member from an initial cross-sectional dimension to an expanded cross-sectional dimension greater than the initial cross-sectional dimension when the elastically deformable member is longitudinally compressed to selectively adjust the tissue-removing head from the initial cross-sectional dimension to the expanded cross-sectional dimension;
wherein the expansion mechanism includes an actuator and the tissue-removing catheter houses the actuator, the actuator being selectively movable axially within the tissue-removing head to elastically compress the elastically deformable member.

US Pat. No. 10,478,210

ENDOSCOPIC SURGICAL BLADE AND METHOD OF USE THEREOF

A.M. SURGICAL, INC., Smi...

1. A low-profile surgical blade, comprising;a proximal end;
a distal end;
a top edge;
a lower edge;
an upper cutting surface and a lower cutting surface at the distal end;
a non-cutting radiused surface at a top end of the upper cutting surface; and
a horizontal mounting surface at the lower edge;
wherein the upper cutting surface and the lower cutting surface meet at a crotch therebetween, wherein the blade is sized to fit at a tip of an endoscope,
wherein the blade comprises a notch on the lower edge that is in contact with a surgical tube, and
wherein the notch is concave, substantially crescent-shaped, and is recessed from the horizontal mounting surface and into a body of the blade.

US Pat. No. 10,478,209

DEFLECTABLE SHAVER TOOL

BIOSENSE WEBSTER (ISRAEL)...

1. A surgical tool comprising:a blade comprising:
a rotatable cutting shaft comprising a distal cutting end and a proximal non-cutting end, and
an outer sheath coaxially surrounding the rotatable cutting shaft, including a cutting window at the distal cutting end, at least a portion of the outer sheath being deflectable;
an actuator coupled to a proximal end of the outer sheath and comprising:
a first slider surrounding a portion of the circumference of the outer sheath, and
a second slider surrounding an opposite portion of the circumference of the outer sheath:
a handpiece comprising a suction portion;
a first wire operatively coupled at its proximal end to the first slider and at its distal end to the outer sheath at a distal end of the outer sheath and a second wire operatively coupled at its proximal end to the second slider and at its distal end to the outer sheath at the distal end of the outer sheath;
wherein the first wire and the second wire deflect the deflectable portion when the actuator is manipulated; and
wherein the outer sheath is operatively coupled to an anchoring ring at the distal cutting end and wherein the anchoring ring is located between the outer sheath and the rotatable cutting shaft.

US Pat. No. 10,478,208

ENDOSCOPIC SUBMUCOSAL DISSECTION HOOD

BOSTON SCIENTIFIC SCIMED,...

7. An endoscopic system comprising:an endoscope comprising an elongate body having a proximal end, a distal end and a working channel disposed within the elongate body;
an endoscopic hood coupled to the distal end of the endoscope, the endoscopic hood comprising:
a first portion comprising a proximal end, a distal end and first and second lumens extending therebetween, wherein the first lumen is in communication with the working channel of the endoscope,
a second portion extending from the distal end of the first portion, said second portion comprising a curved wall with an open distal end and defining a working area adjacent a concave surface of the curved wall and the first lumen, and
a support member extending into the first lumen adjacent to the curved wall;
a first shaft having a proximal end and a distal end, wherein a portion of the first shaft is disposed within the working channel and the first lumen; and
a second shaft having a proximal end and a distal end, wherein a portion of the second shaft is slidably and rotationally disposed along an outer surface of the elongate body and extends through the second lumen.

US Pat. No. 10,478,205

LITHOTRIPSY APPARATUS USING A FLEXIBLE ENDOSCOPE

Gyrus ACMI, Inc., Southb...

1. A method, comprising:manipulating a deflection section at a distal tip of an endoscope toward a stone within the body;
inserting a lithotripsy shaft and a stone retrieval device into a proximal end of a working channel of the endoscope, the lithotripsy shaft and the stone retrieval device configured to extend through the working channel and the deflection section;
extending the stone retrieval device from a distal tip of the deflection section through the lithotripsy shaft;
capturing a stone with the stone retrieval device and bringing the stone substantially in line with a longitudinal axis of a substantially straight or slightly curved portion of the deflection section;
withdrawing the stone retrieval device within the substantially straight or slightly curved shaft of the lithotripsy shaft through a plurality of guide protrusions at a distal tip of the lithotripsy shaft, wherein the plurality of guide protrusions facilitate passage of wires or filaments of the stone retrieval device there through;
extending the lithotripsy shaft toward the stone; and
driving the lithotripsy shaft under power with a lithotripsy shaft driver toward the stone to break it up with force.

US Pat. No. 10,478,202

SHOCK WAVE VALVULOPLASTY DEVICE WITH MOVEABLE SHOCK WAVE GENERATOR

SHOCKWAVE MEDICAL, INC., ...

1. A device for softening and/or breaking tissue calcifications comprising:an elongate tube;
a chamber located at the distal end of the elongate tube, said chamber having a longitudinal axis and being fillable with a liquid; and
a shock wave generator within the chamber, wherein the shock wave generator is arranged to produce a shock wave within the chamber to propagate through the liquid for impinging upon the calcified tissue, and wherein the shock wave generator is carried by an elongate element that is slidably received within the chamber such that the shock wave generator is configured to move from a first location within the chamber to a second location within the chamber that is displaced along the longitudinal axis from the first location.

US Pat. No. 10,478,201

INSERTABLE MEDICAL DEVICE SYSTEM WITH PLAQUE TREATMENT PORTION AND METHODS OF USING

Surmodics, Inc., Eden Pr...

1. A plaque treatment catheter assembly comprising:a first catheter tube having inner and outer diameters and capable of being inserted within vasculature;
a second catheter tube having inner and outer diameters, the outer diameter of the second catheter tube being smaller than the inner diameter of the first catheter tube and capable of moving within and out of the first catheter tube, the second catheter tube having a distal portion comprising one or more plaque treatment portion(s) on an outer surface of the second catheter tube, wherein all or a portion of the second catheter tube including the one or more plaque treatment portion(s) is capable of outward expansion in response to force of an outer surface of an expansion member; and
wherein the expansion member is movable within and out of the inner diameter of the second catheter tube when in a contracted state.

US Pat. No. 10,478,199

METHODS, SYSTEMS, AND DEVICES FOR DIAGNOSING AND TREATING INTERVERTEBRAL DISC DEGENERATION

Trinity Orthopedics, LLC,...

1. A method of accessing an intervertebral disc located within an intervertebral disc space adjacent a vertebra having a pedicle, a vertebral body and a vertebral endplate, the method comprising:positioning a first cannula within the vertebra substantially along an axis of the pedicle, the cannula coursing, at least in part, along a first curvilinear path at a first trajectory through at least a portion of the vertebral body to the vertebral endplate;
advancing a translatable flexible curvilinear bone penetrating instrument through a lumen of the first cannula; and
penetrating the vertebral endplate with the translatable flexible curvilinear bone penetrating instrument to enter into the intervertebral disc space thereby creating a first defect in the vertebral endplate at a first location;
repeating the positioning, the advancing, and the penetrating steps thereby creating a plurality of additional defects in the vertebral endplate at additional unique locations;
wherein trajectories of additional curvilinear paths are the same as or different from the first trajectory of the first curvilinear path.

US Pat. No. 10,478,197

MINIMALLY INVASIVE BONE SPARING ACETABULAR REAMER

1. An orthopedic bone cutter, comprising:a) a cutting shell having a base and a shell sidewall with a curvature that comprises at least a portion of a hemisphere, the cutting shell extending from said base towards an imaginary apex, an opening having an opening perimeter extends through the shell sidewall at the imaginary apex to a cutting shell interior, a rotational axis extends through the imaginary apex, the cutting shell being rotatable about the rotational axis;
b) a flange having an annular flange sidewall defining a flange opening, the flange extending from the shell opening perimeter at a flange distal end to a flange proximal end positioned within the shell interior;
c) a plurality of outwardly extending and spaced apart shell cutting teeth;
d) an insert extending from an insert proximal end to an insert distal end, the insert comprising an annular insert sidewall that meets an insert end wall at the insert distal end, the insert positioned within the flange opening along the rotational axis, wherein the insert distal end faces the imaginary apex;
e) a plurality of outwardly extending and spaced apart insert cutting teeth; and
f) wherein the insert is capable of rotational and axial movement about the rotational axis.

US Pat. No. 10,478,194

OCCLUSIVE DEVICES

Covidien LP, Mansfield, ...

1. An implant for occluding a target area of a patient's vasculature, comprising:a frame comprising a lattice formed of a first plurality of braided filaments that define a first plurality of openings, the first openings having a pore size of from about 1 ?m to about 400 ?m, the frame comprising a distal region and a proximal region, the frame being expandable from a compressed configuration to an expanded configuration in which the frame has a generally spherical shape, and wherein the first plurality of filaments are coupled together at a hub disposed at a proximal end of the frame;
a first mesh component coupled to the frame along at least a first portion of the proximal region, the first mesh component comprising a second plurality of braided filaments that define a second plurality of openings, the second pluralities of filaments and openings collectively defining a mesh porosity permitting blood flow therethrough, the mesh porosity being less than a porosity of the frame, such that blood flow into the implant is more restricted along the proximal region than along the distal region of the frame; and
a second mesh component coupled to the frame along at least a second portion of the proximal region, the second portion differing from the first portion, the second mesh component comprising a third plurality of braided filaments that define a third plurality of openings,
wherein a proximal end of the implant is configured to be detachably coupled to a delivery device.

US Pat. No. 10,478,188

IMPLANTABLE LAYER COMPRISING A CONSTRICTED CONFIGURATION

Ethicon LLC, Guaynabo, P...

1. A staple cartridge assembly, comprising:a cartridge body comprising a deck;
a plurality of staples; and
an implantable layer positioned over said deck, wherein said implantable layer comprises:
a first plurality of fibers comprised of a first material having a first thermal transition temperature, wherein said first fibers are interconnected at a plurality of nodes, wherein said plurality of nodes define a plane, and wherein said plurality of nodes is configured to reinforce a three-dimensional structure of said implantable layer; and
a second plurality of fibers comprised of a second material having a second thermal transition temperature, wherein said second thermal transition temperature is lower than said first thermal transition temperature, wherein said second material is intermixed with said first material, wherein said second fibers are contracted within said implantable layer during a process which exposes said implantable layer to a process temperature which exceeds said second thermal transition temperature, and wherein a first portion of said second fibers are constricted at said plurality at nodes and a second portion of said second fibers are laterally expanded away from said plane.

US Pat. No. 10,478,186

ELECTROSURGICAL DEVICE WITH DISPOSABLE SHAFT HAVING RACK AND PINION DRIVE

Ethicon LLC, Guaynabo, P...

1. An apparatus for operating on tissue, the apparatus comprising:(a) a surgical end effector;
(b) a shaft assembly, wherein the surgical end effector is coupled with the shaft assembly, wherein the shaft assembly defines a longitudinal axis, wherein the shaft assembly comprises a translating member extending through the shaft assembly, wherein the translating member is movable parallel to the longitudinal axis; and
(c) an interface assembly structured and positioned to engage the shaft assembly, wherein the interface assembly comprises:
(i) an elongate beam in communication with the translating member,
(ii) a drive shaft, wherein the drive shaft is rotatable about a drive shaft axis, and
(iii) a spur gear in communication with the drive shaft, wherein the spur gear is further in communication with the elongate beam, wherein gear teeth of the spur gear are structured and positioned to drive the elongate beam along a path that is parallel to the longitudinal axis of the shaft assembly.

US Pat. No. 10,478,183

ADJUNCT RELEASE FOR SURGICAL STAPLERS

Ethicon LLC, Guaynabo, P...

1. A staple cartridge assembly for use with a surgical stapler, comprising:a cartridge body having a plurality of staple cavities on a tissue-facing surface thereof, each staple cavity having a staple disposed therein that is configured to be deployed into tissue, and the cartridge body having a plurality of connection cavities separate from the plurality of staple cavities on the tissue-facing surface;
an adjunct disposed on the tissue-facing surface of the cartridge body, the adjunct having a plurality of protrusions disposed on an adjunct surface configured to contact the tissue-facing surface, the plurality of protrusions being configured to extend into and engage with the plurality of connection cavities; and
a plurality of drivers disposed within the cartridge body, each driver having at least one adjunct releasing mechanism located thereon such that the plurality of drivers are configured to drive the plurality of protrusions of the adjunct out of the plurality of connection cavities and cause the adjunct to detach from the cartridge body when the plurality of drivers are advanced into the staple cavities to deploy the staples.

US Pat. No. 10,478,175

METHOD AND APPARATUS FOR MENISCAL REPAIR

Linvatec Corporation, La...

1. An anchor, comprising:an elongated cylindrical body having a distal end and a proximal end, a longitudinal axis extending between the distal end and the proximal end, and a cylindrical outer surface radially offset from the longitudinal axis, the distal end having a distal slot opening on the cylindrical outer surface of the body and extending from the distal end of the body proximally along the longitudinal axis of the body, and the proximal end having a proximal slot opening on the cylindrical outer surface of the body and extending from the proximal end of the body distally along the longitudinal axis of the body, and wherein the elongated body is non-tubular;
the distal slot comprising a wide section and a narrow section, wherein the wide section has a width configured to slidably accommodate a suture in the wide section and the narrow section has a width configured to bind the suture in the narrow section, and further wherein the wide section is disposed distally of the narrow section.

US Pat. No. 10,478,169

TISSUE RETRACTOR AND METHOD OF USE

Globus Medical, Inc., Au...

1. A multi-blade retractor system comprising:a retractor frame comprising a first arm and a second arm;
a first blade coupled to a distal end of the first arm, the first blade having a first channel; and
a second blade coupled to a distal end of the second arm;
wherein the first blade includes an anchor member receiving portion at a distal end of the first blade, the anchor member receiving portion slidably received in the first channel of the first blade,
wherein the anchor member receiving portion is configured to receive an anchor member capable of fixation into a bone member, and
an extension portion slidably received in the first channel of the first blade such that the extension portion directly rests atop the anchor member receiving portion
wherein the first blade has a second channel, the anchor member receiving portion is slidably received in the second channel of the first blade, but the extension portion is not received in the second channel of the first blade.

US Pat. No. 10,478,158

PEROPERATIVE SENSING HEAD ADAPTED TO BE COUPLED TO AN ABLATION TOOL

CENTRE NATIONAL DE LA REC...

1. A system for performing neurosurgery comprising:a handheld device comprising an excision tool and a probe, the handheld device configured to be manipulated by a neurosurgeon to detect and excise tumorous tissue of a patient's central nervous system, the probe configured to generate a first output corresponding to detection of beta particles and gamma radiation emitted by radioactive tracers absorbed by the tumorous tissue and a second output corresponding to detection of gamma radiation alone;
a processing system having a monitor, the processing system configured to be coupled to the handheld device to receive and process the output of the probe and compare the first output to the second output to determine a concentration of beta particles emitted by the radioactive tracers, the processing system generating and displaying on the monitor, in real time, an image corresponding to the concentration of beta particles emitted by the radioactive tracers in the tumorous tissue that identifies a margin of the tumorous tissue, the image enabling the neurosurgeon to manipulate the handheld device to excise, and observe treatment of, tumorous tissue in real time.

US Pat. No. 10,478,149

METHOD OF AUTOMATICALLY POSITIONING AN X-RAY SOURCE OF AN X-RAY SYSTEM AND AN X-RAY SYSTEM

Siemens Healthcare GmbH, ...

1. A method for determining the position of a mobile X-ray detector in an X-ray system, wherein the X-ray system is provided with a 3D camera, the method comprising:acquiring a digital 3D image of the mobile X-ray detector using the 3D camera, wherein the mobile X-ray detector has a X-ray receiving portion on a planar surface and a plurality of passive markers provided on the planar surface having the X-ray receiving portion;
detecting the plurality of passive markers and the markers' pattern in the digital 3D image, wherein the pattern of the markers' defines the plane of the mobile X-ray detector having the X-ray receiving portion;
estimating the plane of the mobile X-ray detector's X-ray receiving portion;
estimating 6 DOF pose of the mobile X-ray detector, wherein the 6 DOF pose defines the position and orientation of the mobile X-ray detector in the 3D camera's coordinate system; and
transforming the 6DOF pose of the mobile X-ray detector in the 3D camera's coordinate system into the corresponding position and orientation in the X-ray base coordinate system,
wherein the mobile X-ray detector has four corners and the plurality of passive markers,
are provided in a specific corner pattern at each of the four corners designating the particular corner,
wherein detecting the plurality of passive markers and the marker's pattern in the digital 3D image comprises determining the specific corner patterns, and determining the mobile X-ray detector's orientation.

US Pat. No. 10,478,146

RADIATION IRRADIATION DEVICE

FUJIFILM Corporation, To...

1. A radiation irradiation device comprising:a radiation generating part that generates radiation;
an arm part having the radiation generating part attached to one end thereof,
a main body part having the other end of the arm part connected thereto,
an electric power supply part provided at the main body part, and
a cable part for electrically connecting the power supply part and the radiation generating part, wherein the electric power supply part has a battery part having lithium ion batteries connected in parallel, and a first booster circuit part that boosts a voltage output from the battery part, and
wherein the radiation generating part has a second booster circuit part that further boosts a voltage that is boosted by the first booster circuit part and is input to the radiation generating part via the cable which is extended along the arm part.

US Pat. No. 10,478,142

METHOD AND APPARATUS OF SPECTRAL DIFFERENTIAL PHASE-CONTRAST CONE-BEAM CT AND HYBRID CONE-BEAM CT

University of Rochester, ...

1. A method of cone beam CT imaging of a human breast without penetrating the chest cavity of a patient, comprising:acquiring projection images of the breast taken at different view angles by using a polychromatic x-ray source irradiating the breast but not the chest cavity with primary radiation, an energy-resolving detector having a plurality of energy channels, and a grating system;
said acquiring comprising acquiring, for each of the plurality of energy channels of the detector, a respective plurality of the projection images of the breast taken at different view angles;
performing three-dimensional (3D) computed tomography reconstructions of the breast for each of the plurality of energy channels to produce a respective plurality of differential phase contrast 3D reconstruction images; and
combining the plurality of differential phase 3D reconstruction images to thereby produce one or more output images of the breast;
wherein said combining of the plurality of differential phase 3D reconstruction images comprises assigning different weights to the images being combined.

US Pat. No. 10,478,141

METHOD FOR ESTIMATING THE DISTRIBUTION OF BONE MINERAL DENSITY IN AT LEAST ONE PORTION OF A PERSON'S SKELETON

AMVALOR, Paris (FR)

1. An estimation method for estimating the bone mineral density distribution in at least one portion of a person's skeleton, the skeleton being made up of bone tissue, the bone tissue being surrounded by soft tissue, in turn surrounded by an outline (E) of the person, the method being characterized in that it comprises generating:a geometrical representation in three dimensions of said portion of the person's skeleton;
a geometrical representation in three dimensions of at least one portion of the outline (E) containing said portion of the person's skeleton;
at least one first X-ray image of said at least one portion of the skeleton, this first image being generated by observing a projection onto a first detection surface of X-rays, coming from a first source, the first image being generated by projecting X-rays and representing the person as observed from a first observation angle of incidence; and
at least one second X-ray image of said at least one portion of the skeleton, the second image being generated by projecting X-rays and representing the person as observed from a second observation angle of incidence distinct from the first observation angle of incidence; and then
using predetermined software and for a plurality of given X-rays selected from among said projected X-rays, estimating for each given X-ray:
a value for the thickness of soft tissue through which the given X-ray has passed;
a value for the thickness of bone tissue through which the given X-ray has passed; and
a value for the overall attenuation of the given X-ray between its source and its projection onto the detection surface onto which it is projected; and
using the thickness value for soft tissue through which the given X-ray passes, and using an estimate for an attenuation coefficient of the soft tissues through which the given X-ray passes, deducing firstly a value for the attenuation of the given X-ray due to the thickness of soft tissue through it has passed and secondly a value for the attenuation of the given X-ray due to the thickness of bone tissue through which it has passed; and then
using the value for the thickness of bone tissue through which the given X-ray has passed, the value for the attenuation of the given X-ray due to the thickness of bone tissue through which it has passed, and the overall value for attenuation of the given X-ray, the software estimates a value representative of the bone mineral density of the bone tissue through which the given X-ray has passed.

US Pat. No. 10,478,140

NEAREST AVAILABLE ROADMAP SELECTION

KONINKLIJKE PHILIPS N.V.,...

1. A system for vascular roadmapping comprising:an imaging device having an x-ray source and an x-ray detector, for generating a fluoroscopy image;
a data base including contrast-enhanced images, wherein the contrast-enhanced images are generated with different imaging parameters;
a user interface configured to select intended imaging parameters; and
a processor configured:
to determine current imaging parameters of the imaging device,
to determine a contrast-enhanced image out of the contrast-enhanced images generated with respective imaging parameters, wherein the contrast-enhanced image has imaging parameters closest to the intended imaging parameters,
to select the contrast-enhanced image to obtain a selected contrast-enhanced image,
to adjust the current imaging parameters of the imaging device to the imaging parameters of the selected contrast-enhanced image, and
to determine that a state of the imaging device is a ready-for-use-state based on a completion of an adjustment of the current imaging parameters of the imaging device from the current imaging parameters to the imaging parameters of the selected contrast-enhanced image,
wherein the imaging parameters of the selected contrast-enhanced image comprises a position of the x-ray source and the x-ray detector, an orientation of the x-ray source and the x-ray detector, settings of the x-ray source, and settings of the x-ray detector, and
wherein the user interface is further configured to indicate the ready-for-use-state or the not-ready-for-use-state of the imaging device.

US Pat. No. 10,478,138

RT-CT INTEGRATED DEVICE

SHENYANG NEUSOFT MEDICAL ...

1. A radiation therapy computed tomography (RT-CT) integrated device comprising a radiation therapy (RT) device and a computed tomography (CT) device, wherein,a radiation-therapy centerline of the radiation therapy (RT) device and a scanning centerline of the computed tomography (CT) device are on a same axis,
the radiation therapy (RT) device and the computed tomography (CT) device are at a same end of a treatment table;
the radiation therapy (RT) device and the computed tomography (CT) device are integrated onto a support system;
the support system comprises a support base provided with a mounting portion,
the computed tomography (CT) device comprises a computed tomography (CT) device rotatable gantry,
the radiation therapy (RT) device comprises a radiation therapy (RT) device rotatable gantry,
the computed tomography (CT) device rotatable gantry is provided with a computed tomography (CT) device ray emitter and a computed tomography (CT) device ray receiver,
the radiation therapy (RT) device rotatable gantry is provided with a radiation therapy (RT) device ray emitter,
the computed tomography (CT) device rotatable gantry and the radiation therapy (RT) device rotatable gantry are both socket-jointed on the mounting portion, and are disposed coaxially with the mounting portion,
the computed tomography (CT) device rotatable gantry and the radiation therapy (RT) device rotatable gantry are both fixed in an axial direction and a radial direction;
the computed tomography (CT) device rotatable gantry and the radiation therapy (RT) device rotatable gantry are both rotatable along a circumferential direction;
the radiation therapy (RT) device rotatable gantry, the computed tomography (CTS) device rotatable gantry and the mounting portion are socket-jointed sequentially in the axial direction,
each socket-joint for connecting the radiation therapy (RT) device rotatable gantry, the computed tomography (CT) device rotatable gantry and the mounting portion sequentially is fixed in the axial direction and the radial direction; and
each socket-joint for connecting the radiation therapy (RT) device rotatable gantry, the computed tomography (CT) device rotatable gantry and the mounting portion sequentially is rotatable along the circumferential direction.

US Pat. No. 10,478,137

MULTIPLE IMAGING MODALITY IMAGING APPARATUS

KONINKLIJKE PHILIPS N.V.,...

1. An imaging apparatus, comprising:a first imaging modality;
a second imaging modality, wherein the first and second imaging modalities are in alignment with scanning zones for scanning an object or subject;
a third imaging modality which is selectively moveable between a first location in which the third imaging modality is in alignment with the scanning zones for scanning the object or subject and a second location in which the third imaging modality is outside of alignment with the scanning zones; and
an alignment unit that supports the third imaging modality, wherein the alignment unit provides adjustment of at least of a position or orientation of third imaging modality with respect to the scanning zones and provides angular variation in rotation around X and Z axes.

US Pat. No. 10,478,133

SYSTEMS AND METHODS FOR CALIBRATING A NUCLEAR MEDICINE IMAGING SYSTEM

General Electric Company,...

1. A method, comprising:detecting, with a plurality of detectors, photons emitted by a calibration source comprising a radioactive line source and a fluorescence source, while pivoting one or more detectors of the plurality of detectors;
applying a geometrical correction to energy measurements of the detected photons, wherein applying the geometrical correction includes increasing photon counts of at least one pixel of the one or more detectors according to the pivoting of the one or more detectors; and
calibrating, with a processor communicatively coupled to the plurality of detectors, each detector of the plurality of detectors based on the geometrically-corrected energy measurements of the detected photons.

US Pat. No. 10,478,131

DETERMINING BASELINE CONTEXTS AND STRESS COPING CAPACITY

Samsung Electronics Compa...

1. A method for monitoring a health characteristic of a user based on one or more biological measurements, comprising:determining a current context of a user;
accessing a plurality of contexts for the user, wherein:
each of the plurality of contexts identifies a context-specific baseline health value; and
each of the plurality of contexts is defined at least in part by a plurality of recorded events each comprising one or more of repeated biological states, repeated user activity, or space-time coordinates of the user;
identifying from the plurality of contexts a predefined user context corresponding to the current context of the user;
monitoring the health characteristic of the user based on one or more bio-sensing measurements in comparison to the context-specific baseline health value corresponding to the identified predefined user context;
detecting, based on monitoring the health characteristic, a plurality of event pairs, each event pair comprising:
a first event corresponding to the health characteristic of the user being within a first pre-defined variability zone; and
a second event corresponding to the health characteristic of the user being within a second pre-defined variability zone;
determining, for each event pair, an amount of time between the first and second event; and
determining a context-specific health-resiliency measurement specific to the user, the identified predefined user context, and the health characteristic by averaging over the plurality of event pairs the determined amount of time between the first and second events.

US Pat. No. 10,478,130

PLAQUE VULNERABILITY ASSESSMENT IN MEDICAL IMAGING

Siemens Healthcare GmbH, ...

1. A method for assessing plaque vulnerability of a patient in medical imaging, the method comprising:extracting an anatomical feature of a vessel or plaque and a morphological feature of the plaque from a scan of the patient by a medical imaging scanner;
obtaining a hemodynamic feature of the patient from a hemodynamic sensor or personalized modeling of the vessel based on the scan;
receiving at an interface a biochemical feature from a blood test of the patient, the biochemical feature including a level of high sensitive troponin;
calculating by a machine-implemented classifier a risk score for plaque rupture for the patient and a risk stratification, both the risk score and risk stratification calculated by the machine-implemented classifier from the anatomical, morphological, hemodynamic, and biochemical features; and
transmitting the risk score for the patient to a display.

US Pat. No. 10,478,129

METHODS FOR IMPROVING RESPONSE TIME, ROBUSTNESS AND USER COMFORT IN CONTINUOUS ESTIMATION OF BIOPHYSIOLOGICAL RATES

SAMSUNG ELECTRONICS CO., ...

1. An apparatus for determining a biophysiological feature, the apparatus comprising:a memory having machine instructions stored therein;
a processor coupled to the memory;
a biophysiological sensor coupled to the processor, the biophysiological sensor configured for application to a patient and operable for detecting signals in the patient associated with measuring a quasiperiodic function; and
an input/output device;
wherein the processor executes the machine instructions to:
receive a quasiperiodic data stream for the measured quasiperiodic function from the biophysiological sensor,
remove at least a portion of an offset from the quasiperiodic data stream to provide a smoothed data stream by filtering the quasiperiodic data stream through a bandpass filter and phase compensating the filtered quasiperiodic data stream,
transform the smoothed data stream into an analytic data stream using a Hilbert transform approximation,
calculate a time derivative associated with a phase angle of the analytic data stream,
provide, to a user via the input/output device, an output data stream derived from a frequency, wherein the frequency is the time derivative of the quasiperiodic data stream and wherein the output data stream comprises the biophysiological feature, and
mask the output data stream while a sensor motion fault is detected.

US Pat. No. 10,478,115

HANDHELD HOME MONITORING SENSORS NETWORK DEVICE

1. A device for obtaining a parameter for nitric oxide (NO) in exhaled air, said device comprising:a housing defining a conduit having an inlet and an outlet, said conduit comprising a Gaussian surface for collecting condensate from the exhaled air, the Gaussian surface formed such that condensate is collected on the Gaussian surface, the conduit further comprising a thermo-electric device arranged for cooling the conduit to generate the condensate from the exhaled air, the conduit further comprising a sensor, said sensor being disposed on the Gaussian surface, said sensor for determining said parameter in the condensate on the Gaussian surface and for generating an electrical signal representing said parameter based on airflow generated by a person blowing in said conduit at said inlet such that the airflow contacts the Gaussian surface and forms the condensate, said sensor having an electrical output for outputting said electrical signal,
an analog-to-digital converter having a converter input and a converter output, said converter input being electrically connected to said electrical output of said sensor such that the electrical signal is converted to a digital signal by the analog-to-digital converter, and
a processor having a first digital input and a second digital input and a first digital output, said first digital input of said processor being electrically connected to said converter output for receiving said digital signal,
wherein said sensor is a NO sensor capable of measuring NO in condensate of exhaled air.

US Pat. No. 10,478,113

BLADDER EVENT DETECTION FOR DIAGNOSIS OF URINARY INCONTINENCE OR TREATMENT OF LOWER URINARY TRACT DYSFUNCTION

THE CLEVELAND CLINIC FOUN...

1. A system comprising:a sensing device adapted to be implanted within a patient's bladder, comprising:
a pressure sensor comprising a bridge-type circuit adapted to directly detect a pressure within the patient's bladder;
a wireless transceiver adapted to transmit a signal indicating the pressure within the patient's bladder; and
a battery adapted to provide power to the pressure sensor,
wherein at least one of the circuit, the wireless transceiver, and the battery is sealed within a biocompatible housing; and
a signal processing device comprising:
a wireless transceiver adapted to receive the signal indicating the detected pressure within the patient's bladder;
a processor to execute instructions stored in memory to process the signal and at least:
filter the signal indicating the detected pressure with a low-pass filter with a cutoff frequency tuned for the patient to provide a filtered signal;
apply a multi-level discrete wavelet transform to the filtered signal to provide a transformed signal in a wavelet domain;
apply an adaptive thresholding procedure to the transformed signal in the wavelet domain to detect a bladder event and characterize the bladder event as a voiding contraction event, a non-voiding contraction event, or a non-contraction event based on at least one property of the bladder event according to one or more tunable parameters customized for the patient.

US Pat. No. 10,478,112

ENHANCING DIAGNOSIS OF DISORDER THROUGH ARTIFICIAL INTELLIGENCE AND MOBILE HEALTH TECHNOLOGIES WITHOUT COMPROMISING ACCURACY

President and Fellows of ...

1. A computer-implemented method for evaluating an individual for a behavioral disorder, a developmental delay, or a neurological impairment; said method comprising:(a) displaying a plurality of questions relating to said behavioral disorder, said developmental delay, or said neurological impairment;
(b) receiving an input comprising a response to at least one of said plurality of questions;
(c) generating an output, based on said input, using a software module comprising a classifier trained with data from a plurality of individuals having said behavioral disorder, said developmental delay, or said neurological impairment;
wherein said output comprises an indication of whether said behavioral disorder, said developmental delay, or said neurological impairment is present in said individual; and
wherein said output has an accuracy of at least 90%.

US Pat. No. 10,478,110

METHOD FOR MEASURING SOCIAL RELATIONSHIP USING HEART RHYTHM PATTERN (HRP)

CENTER OF HUMAN-CENTERED ...

1. A social relationship determining method comprising:detecting, with an electrocardiogram (ECG) sensor, ECG signals from at least two subjects;
defining, with a data processor, a heart rhythm pattern (HRP) data spectrum including a beat per minute (BPM) from the ECG signals of the at least two subjects;
extracting, with the data processor, a difference X value between the beats per minute (BPM) of the heart rhythm pattern (HRP) data spectrum of the at least two subjects defined from the ECG signals;
extracting, with the data processor, an r square value via a correlation analysis of each of the HRP data spectrum;
determining, with an analyzer configured for estimating intimacy coupled to the data processor, a social relationship between the at least two subjects by using the following equation: Y=0.00943167*X, where Y is a result value, wherein the social relationship is determined as being strong when the r square value is larger than the result value Y, otherwise, the social relationship is determined as being weak; and
displaying, with a display coupled to the data processor, a strength of the social relationship based on a comparison of the result value Y with the r square value.

US Pat. No. 10,478,109

METHODS AND APPARATUS FOR SELECTIVELY OCCLUDING THE LUMEN OF A NEEDLE

Magnolia Medical Technolo...

1. A device for parenterally transferring fluid between a patient and a fluid container, the device comprising:a housing defining a fluid flow path configured to transfer a flow of fluid;
a needle having a distal end portion and a proximal end portion, and defining a lumen therebetween, the distal end portion having a closed distal end surface and being configured for insertion into the patient, the distal end portion defining an opening proximal to the closed distal end surface and in fluid communication with the lumen, the proximal end portion configured to be fluidically coupleable to the housing to place the lumen of the needle in fluid communication with the fluid flow path; and
an occlusion member configured to selectively obstruct the opening of the needle to control fluid flow to or from the fluid flow path, the occlusion member having a first state in which a distal end surface of the occlusion member is substantially coplanar with the closed distal end surface of the needle to obstruct the opening of the needle during insertion into the patient, and a second state in which the distal end surface of the occlusion member is nonparallel to the distal end surface of the needle such that the opening of the needle is unobstructed after the needle has been inserted into the patient allowing fluid transfer between the patient and the fluid flow path.

US Pat. No. 10,478,104

GLUCOSE SENSING CONTACT LENS

MENICON CO., LTD., Nagoy...

13. A contact lens system, comprising:a contact lens, comprising:
a body having an eye-contacting surface configured to contact the surface of a user's eye;
a glucose sensing area operably encapsulated within the body, the glucose sensing area having a first state and a second state, wherein the glucose sensing area transitions between the first state and the second state as a concentration of glucose varies;
an optical sensor disposed between the eye contacting surface and the glucose sensing area;
a transmitter communicatively coupled to the optical sensor; and
a power supply coupled to the wireless transmitter; and
a wireless receiver, comprising:
a transceiver module operably coupled to an antenna, the transceiver module being configured to receive the data transmitted by the wireless transmitter;
a user interface module configured to receive input from the user;
a control module configured to control operational aspects of the contact lens system;
a memory module configured to receive and maintain computer-readable information;
a processor module configured to execute the computer-readable information stored within the memory module to operate the wireless receiver; and
a receiver power supply;
wherein the glucose sensing area prevents light from reaching the optical sensor while in the first state and allows light to pass through the glucose sensing area to expose the optical sensor to the light while in the second state.

US Pat. No. 10,478,097

NEURAL EVENT DETECTION

Innovative Surgical Solut...

1. A neural monitoring system for detecting an artificially-induced mechanical response of a muscle to a stimulus provided within an intracorporeal treatment area of a human subject, the intracorporeal treatment area including a nerve that innervates the muscle, the neural monitoring system comprising:a non-invasive mechanical sensor configured to be placed in mechanical communication with the muscle and to generate a mechanomyography output signal corresponding to a sensed mechanical movement of the muscle; and
a processor in communication with the mechanical sensor and configured to:
receive the mechanomyography output signal from the mechanical sensor;
determine a frequency component of the mechanomyography output signal, wherein the frequency component has a peak magnitude relative to adjacent frequencies; and
provide an indication of an artificially induced mechanical muscle response to a user if the determined frequency component has a frequency within the range of greater than 0 Hz to about 20 Hz.

US Pat. No. 10,478,096

NEURAL EVENT DETECTION

Innovative Surgical Solut...

1. A neural monitoring system for detecting an artificially-induced mechanical response of a muscle to an electrical stimulus provided within an intracorporeal treatment area of a human subject at a stimulation frequency, the intracorporeal treatment area including a nerve that innervates the muscle, the neural monitoring system comprising:a non-invasive mechanical sensor configured to be placed in mechanical communication with the muscle and to generate a mechanomyography output signal corresponding to a sensed mechanical movement of the muscle; and
a processor in communication with the mechanical sensor and configured to:
receive the mechanomyography output signal from the mechanical sensor;
determine a frequency component of the mechanomyography output signal, wherein the frequency component has a peak magnitude relative to adjacent frequencies; and
provide an indication of an artificially-induced mechanical muscle response to a user if the determined frequency component is either equal to, or an integer multiple of the stimulation frequency.

US Pat. No. 10,478,093

EXHALED-AIR PRESSURE MEASURING DEVICE

YUBA CORPORATION, Hirosh...

1. An exhaled-air pressure measuring device, comprising:a blowout connection portion;
a mouthpiece portion configured to be held by a user in the mouth such that air is exhaled by the user, wherein the mouthpiece portion is in fluid communication with the blowout connection portion;
an indication section; and
a measuring device body which measures the pressure of the exhaled air into the mouthpiece portion by the user, and on the basis of a result of the measurement, decides on an exhaled-air pressure level which corresponds to the pressure of the exhaled air, wherein the measuring device body comprises:
a storage section for storing threshold data representing predetermined thresholds of a plurality of the exhaled-air pressure levels, the predetermined thresholds corresponding to a plurality of types of blowouts suitable for different usage purposes;
a deciding section for deciding on the exhaled-air pressure level from the result of the measurement on the basis of the predetermined thresholds; and
a terminal connected to an external storage device so that the external storage device accesses the storage section,
wherein the external storage device is configured to replace the threshold data with other threshold data upon connection via the terminal, wherein the indication section is configured to provide a level indicator for indicating whether a blowout connected to the blowout connection portion is suitable for a usage purpose based on the exhaled air pressure level of the user exceeding one of the predetermined thresholds.

US Pat. No. 10,478,087

OPEN BORE FIELD FREE LINE MAGNETIC PARTICLE IMAGING SYSTEM

ASELSAN ELEKTRONIK SANAYI...

1. An open bore coil system for enabling electronic steering and rotation of a Field Free Line (FFL) inside a volume, comprising:a first coil group (1), the first coil group (1) comprising a first coil (1a), a second coil (1b), a third coil (1c), and a fourth coil (1d), the first coil (1a), the second coil (1b), the third coil (1c), and the fourth coil (1d) being fed with respective first current (I1a), second current (I1b), third current (I1c), and fourth current (I1d); and
a second coil group (2), the second coil group (2) comprising a first coil (2a), a second coil (2b), a third coil (2c), and a fourth coil (2d), the first coil (2a), the second coil (2b), the third coil (2c), and the fourth coil (2d) being fed with respective first current (I2a), second current (I2b), third current (I2c), and fourth current (I2d),
wherein the coils in the respective first coil group (1) and second coil group (2) are located as coil pairs placed side by side and fed with alternating current directions,
wherein the first coil (1a) and the second coil (1b) of the first coil group (1) form a first coil pair (1a-1b), the first coil pair (1a-1b) being fed with the same current direction, thereby generating a magnetic field in a first z-direction (6), the first z-direction (6) being selected from the group consisting of +z and ?z,
wherein the third coil (1c) and the fourth coil (1d) of the first coil group (1) form a second coil pair (1c-1d), the second coil pair (1c-1d) being fed with an opposite current direction with respect to the first coil (1a) and the second coil (1b) of the first coil group (1), thereby generating a magnetic field in a second z-direction (7) selected from the group consisting of +z and ?z, the second z-direction (7) being the opposite direction of the first z-direction (6), wherein if the first z-direction (6) is +z, then the second z-direction (7) is ?z, and if the first z-direction (6) is ?z, then the second z direction (7) is +z,
wherein the x component (3) and the y component (4) of the magnetic field vanish on a planar or non-planar surface between a top coil pair (1a-1c), the top coil pair (1a-1c) comprising first coil (1a) and third coil (1c) and a bottom coil pair, the bottom coil pair (1b-1d) comprising second coil (1b) and fourth coil (1d),
wherein the z-axis component of the magnetic field vanishes on a planar or non-planar surface between the first coil pairs (1a-1b) and the second coil pair (1c-1d), and
wherein the second coil group (2) is rotated around the z-axis with respect to the first coil group (1) at a rotation angle of theta degrees.

US Pat. No. 10,478,085

APPARATUS FOR ACQUIRING ELECTRIC ACTIVITY IN THE BRAIN AND UTILIZATION OF THE SAME

INTER-UNIVERSITY RESEARCH...

1. A method of using an electric activity information in brain, the method using an apparatus, which includes:one or more needle-like base enabled to be inserted to the brain;
a first electrode a first impedance and acquiring an input of an electric activity of a brain tissue with which the first electrode comes into contact and being provided at a portion of the at least one of the one or more bases;
a pair of second electrodes having a second impedance lower than the first impedance, applying an electric stimulation to the brain tissue and being provided at portions of the at least one of the one or more bases,
wherein the first electrode is positioned at a tip portion of the at least one of the one or more bases and the second electrodes are aligned along the long axis of at least one of the one or more bases at positions closer to a proximal end than the first electrode, and configured to be provided within a range in which the second electrodes are placed in the same nucleus as the first electrode is placed,
and the method comprising:
inserting the at least one or more base into the brain so that the first electrode and the second electrodes are positioned within the same nucleus of the brain;
outputting one or more electric stimulations of one or more single stimulations and/or one or more repetitive stimulations from the second electrodes at the nucleus in which the second electrode is placed;
receiving one or more electric activities in the brain tissue induced based on the one or more electric stimulations output by the first electrode; and
comparing one or more inhibition and/or excitation patterns based on the one or more electric activities with one or more nucleus-specific inhibition and/or excitation patters pre-acquired by stimulating and receiving within the specific nucleus and identifying whether the first electrode is positioned at the specific nucleus.

US Pat. No. 10,478,080

ARRAY PHYSIOLOGICAL DETECTION SYSTEM AND OPERATING METHOD THEREOF

PIXART IMAGING INC., Hsi...

1. An array physiological detection system, arranged in a wearable electronic device, and configured to detect a change of skin microcirculation, the array physiological detection system comprising:a light source configured to be arranged facing a skin area of a user to irradiate a light on the skin area, wherein the light penetrates a surface of the skin area and reaches a dermis of the skin area;
a photosensitive array including a plurality of photosensitive pixels arranged in an array and configured to be arranged facing the skin area of the user, wherein each of the plurality of photosensitive pixels is configured to output a plurality of brightness signals as a photoplethysmography signal by continuously detecting an outgoing light that emits outwardly from the dermis of the skin area; and
a processing unit connecting to the photosensitive array to receive the photoplethysmography signals and configured to
convert the photoplethysmography signals of the plurality of photosensitive pixels respectively into a plurality of frequency domain data, each of the photosensitive pixels in the array having an energy value associated with a selected frequency of the corresponding frequency domain data,
calculate a variation value, which is a sum of energy differences between the energy of every photosensitive pixel in the array and the average value, and an average value of the energy values of the plurality of frequency domain data,
identify different microcirculation states according to a change of the variation value and a change of the average value, and
notify the user of the identified microcirculation states through the wearable electronic device using images or sound.

US Pat. No. 10,478,079

PULSE ESTIMATION DEVICE, PULSE ESTIMATION SYSTEM, AND PULSE ESTIMATION METHOD

PANASONIC INTELLECTUAL PR...

1. A pulse estimation device that estimates a pulse of a subject from information obtained without contact with the subject, the pulse estimation device comprising:a processor;
a memory including instructions that, when executed by the processor, cause the processor to perform operations including:
inputting time-sequential captured images including at least a portion of the subject as an object from a camera;
extracting a skin-color region from each of the captured images;
transmitting a zoom command to the camera that has imaged the captured images or a user of the camera in order to adjust a size of the skin-color region; and
estimating the pulse of the subject based on the skin-color region of the captured images obtained by imaging with the camera, after the zoom command is transmitted,
wherein the operations further include estimating the pulse of the subject based on the captured images before the zoom command is transmitted, and determining whether or not the estimated pulse is stable, and
in a case where the estimated pulse is not stable, transmitting the zoom command.

US Pat. No. 10,478,075

SYSTEM AND METHOD FOR OBTAINING BODILY FUNCTION MEASUREMENTS USING A MOBILE DEVICE

QUALCOMM Incorporated, S...

1. A mobile device for obtaining at least one bodily function measurement, comprising:an outer body sized to be portable for a user;
a processor contained within the outer body;
a plurality of sensors physically coupled to the outer body for obtaining data accessible by the processor; and
a multifunctional surface;
wherein a first sensor of the plurality of sensors is configured to obtain a photoplethysmography (PPG) measurement;
wherein a second sensor of the plurality of sensors is configured to obtain an electrocardiography (ECG) measurement; and
wherein the multifunctional surface comprises at least one of the first or second sensors and wherein the multifunctional surface is configured to, responsive to a contact with the multifunctional surface, (i) cause the first sensor to obtain the PPG measurement, and (ii) transmit a user input signal to the processor;
wherein the second sensor is configured to obtain the ECG measurement in response to the contact; and
wherein the processor is configured to facilitate generation of a blood pressure measurement based on the PPG measurement and the ECG measurement.

US Pat. No. 10,478,066

SYSTEM AND METHOD FOR DETECTION OF CRAVINGS IN INDIVIDUALS WITH ADDICTION

19. A method for detecting drug craving of an individual subject, comprising:the individual subject undergoing a period of supervision wearing physiological sensors, the physiological sensors configured to measure training motion of the individual subject in three dimensions, training Electrodermal Response (EDR), and training temperature;
recording training windows of training motion data in the three dimension, training EDR data, and training temperature data by sensing the training motion, the training EDR, and the training temperature of the individual subject during a period of no drug use;
generating training mean and variance of the training windows of the training motion data, training EDR data, and training temperature data during the period of no drug use;
transforming the three dimensional training motion data in the training windows into training amplitude data;
creating training histogram data of the training amplitude data;
fitting a training curve to the training histogram data;
determining training shape and scale from the training curve;
applying a machine learning to the training mean and variance and training shape and scale determining classification rules during the period of no drug use;
recording monitoring windows of monitoring motion data in the three dimension, monitoring EDR data, and monitoring temperature data by sensing the monitoring motion, the monitoring EDR, and the monitoring temperature of the individual subject during a period of no drug use;
generating monitoring mean and variance of the monitoring windows of the monitoring motion data, monitoring EDR data, and monitoring temperature data during the period of no drug use;
transforming the three dimensional monitoring motion data in the monitoring windows into monitoring amplitude data;
creating monitoring histogram data of the monitoring amplitude data;
fitting a monitoring curve to the monitoring histogram data;
determining monitoring shape and scale from the monitoring curve;
comparing the monitoring mean and variance and monitored shape and scale during the period of monitoring to the classification rules; and
providing a warning of a condition selected from the group consisting of stress, drug cravings, and drug use when the comparison indicates the presence of the condition.

US Pat. No. 10,478,064

DEVICE FOR DETERMINING AN INTRAOCULAR PRESSURE OF AN EYE

INGENEUS PTY LTD., Mt. W...

1. A device for determining an intraocular pressure of an eye of a patient comprising:(a) a housing;
(b) a plunger axially movable within the housing, a first end of the plunger having a tip for contacting the eye;
(c) an indicator arm operatively connected to a second end of the plunger;
(d) a measurement gauge for indicating the intraocular pressure of the eye;
(e) a resilient biasing member having a first end coupled to the indicator arm for biasing the plunger towards an extended position in which the plunger tip protrudes beyond the housing and the indicator arm is biased towards a first position on the measurement gauge; and
(f) a counterbalance for balancing the indicator arm about a pivot such that the device can be used to determine the intraocular pressure of the eye when the plunger is contacting the eye from multiple angles;
wherein applying pressure to the eye via the plunger tip causes the intraocular pressure of the eye to exert an opposing force on the plunger tip causing the plunger to retract into the housing to cause a reciprocal movement of the indicator arm towards a second position thereby indicating the intraocular pressure of the eye on the measurement gauge; and
wherein the gauge and indicator arm are comprised within the housing;
wherein the indicator arm pivots in a plane parallel to the longitudinal axis of housing when pressure is applied to the eye via the plunger tip and the indicator is moving from the first position towards the second position; and
wherein the indicator arm, resilient biasing member, and counterbalance are integrated into a single piece.

US Pat. No. 10,478,053

ENDOSCOPE ILLUMINATION DEVICE

OLYMPUS CORPORATION, Tok...

1. An endoscope illumination device, comprising:a light source that outputs primary light;
a light guide that includes a first end face from which the primary light is radiated, and guides the primary light;
a light converter that is disposed to face the first end face, includes a second end face that the primary light enters, converts part of the primary light into secondary light; and
a holder that holds the light guide and the light converter so that an incident angle of the secondary light that is radiated from a point of intersection of the second end face and an optical axis of the light guide on the first end face and enters the first end face is equal to or larger than an acceptance angle (NA) of the light guide.

US Pat. No. 10,478,052

OBLONG ENDOSCOPE SHEATH

GYRUS ACMI, INC., Southb...

1. An endoscope sheath comprising:a sheath having:
a proximal end,
a distal end, and
a tube extending between the proximal end and the distal end with a single passage;
wherein the sheath is configured to receive all or a portion of an endoscope and provide inside the tube a conduit for communicating fluid between the proximal end of the sheath and the distal end of the sheath when the endoscope is inserted inside the sheath, and
wherein the tube has a non-cylindrical shape that has a cross-section with a circular portion having a diameter substantially matching a diameter of the endoscope and one or more tangent portions that have one or more segments that are tangent to the circular portion at one or more points,
wherein at least a part of a side of the endoscope contacts the circular portion when the endoscope is inserted into the tube, so that the conduit is formed between the side of the endoscope and inside of the tube opposite the circular portion in which the endoscope contacts, and
wherein a cross-sectional shape of the sheath that is orthogonal to a longitudinal axis is varied along a length of the sheath.

US Pat. No. 10,478,050

OPERATION DEVICE FOR INTO-BORE INTRODUCTION DEVICE, AND INTO-BORE INTRODUCTION DEVICE

OLYMPUS CORPORATION, Tok...

1. An endoscope comprising:a longitudinally elongated insertion section having a bending portion;
a grasping section connected to a proximal end of the insertion section, the grasping section adapted to be grasped by a hand of an operator for controlling the insertion section; and
a bending operation knob (1) having a rotational axis and being rotatably connected to a second surface of the grasping section, the rotational axis being transverse to the second surface, (2) comprising a plurality of protrusions protruding radially with respect to the rotational axis, (3) adapted to bend the bending portion of the insertion section, and (4) configured to be engaged by a thumb or one of fingers of the hand of the operator; wherein:
the grasping section includes a third surface adjacent and transverse to the second surface;
the third surface includes a projection (1) extending (a) outwardly from a portion of the third surface and (b) in a first direction transverse from the rotational axis of the bending operation knob and (2) forming a projection surface at its periphery in the first direction between an outer face of the projection and the portion of the third surface; and
the projection surface includes a curved section that (1) extends between a first section of the projection surface facing the insertion section and a second section of the projection surface facing the bending operation knob, (2) is configured to be contacted by the one of the fingers of the hand of the operator grasping the grasping section, and (3) has a curvature radius larger than a curvature radius of another curved section between the first section and a fourth surface of the grasping section.

US Pat. No. 10,478,049

ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. An endoscope comprising:a distal end rigid portion provided at a distal end of an insertion section, and including a through hole penetrating from inside to outside;
an elongated image pickup section provided inside the insertion section, a distal end of the image pickup section being fixed in a state of being inserted in the through hole;
a light guide fiber bundle provided inside the insertion section, and including distal end molded portions each having a distal end molded to have an outer shape that is specified in advance in relation to another component inside the insertion section, the distal end molded portions being inserted and fixed in the through hole, the light guide fiber bundle being formed as one bundle from a proximal end portion to a predetermined branched portion on a distal end side, and formed by being branched into a plurality of bundles on a distal end side with respect to the predetermined branched portion;
a plurality of first cover tubes made of expanded polytetrafluoroethylene, and respectively covering the plurality of bundles from the distal end molded portions to the predetermined branched portion; and
one second cover tube of a material other than the expanded polytetrafluoroethylene, covering the one bundle from the predetermined branched portion to the proximal end portion,
wherein the plurality of bundles of the light guide fiber bundle formed on the distal end side with respect to the predetermined branched portion are disposed while being compressed by the image pickup section through the first cover tubes in such a way that minor axes are 90% or less of a diameter of a case where each bundle of the plurality of bundles is formed to have a circular cross section.

US Pat. No. 10,478,047

SYSTEM AND METHOD FOR USING A CAPSULE DEVICE

Ankon Medical Technologie...

1. A method to navigate a magnetic capsule through a target area, comprisingintroducing a magnetic capsule into the target area, said magnetic capsule has a longitudinal axis and the magnetic dipole placed inside the magnetic capsule has a magnetization direction parallel to the longitudinal axis of the magnetic capsule;
providing an external magnetic control system comprising more than one magnetic generation means, wherein the more than one magnetic generation means are two external magnetic balls;
moving the external magnetic control system to a first position with a first orientation, configured to move the magnetic capsule in a first movement direction, wherein the first movement direction parallel to the longitudinal axis of the magnetic capsule;
generating a combined external magnetic field configured to deliver a force to move the magnetic capsule in the first movement direction,
moving the magnetic capsule horizontally, forwardly or backwardly along the longitudinal axis of the magnetic capsule, by moving the two external magnetic balls horizontally, wherein the magnetization direction of magnetic capsule, a combined magnetic field direction (B) and a direction of the force F received by the magnetic capsule are all parallel to one another;
wherein extending the longitudinal axis of the magnetic capsule, which at this point is parallel to the movement direction of the magnetic capsule, creates a center dividing line, a distance between a capsule magnetic center to a projection line connecting two centers of the external magnetic balls is x, and a distance between a center of one of the magnetic balls to the center dividing line is h.

US Pat. No. 10,478,046

ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. An endoscope, comprising:an insertion section;
a conduit provided inside the insertion section;
a tubular pipe sleeve of a treatment instrument insertion port that is provided in an operation section, the operation section being provided on a proximal end side of the insertion section;
a bent conduit having a bend with a radius such that the conduit communicates with the pipe sleeve; and
a forceps plug that is detachable from the pipe sleeve and includes an opening and a lid,
wherein in a state where the forceps plug is attached to the pipe sleeve, the opening having a center axis offset from a center axis of the pipe sleeve such that the center axis of the opening is eccentric with respect to the center axis of the pipe sleeve in a direction extending outward in a radial direction of the bend in the bent conduit; and
the lid being detachably disposed over the opening and comprising a slit piercing through the lid.

US Pat. No. 10,478,045

FLEXIBLE TUBE FOR AN ENDOSCOPE, ADHESIVE FOR AN ENDOSCOPE, ENDOSCOPE-TYPE MEDICAL DEVICE, AS WELL AS METHOD OF PRODUCING A FLEXIBLE TUBE FOR AN ENDOSCOPE AND METHOD OF PRODUCING AN ENDOSCOPE-TYPE MEDICAL DEVICE

FUJIFILM Corporation, To...

1. A flexible tube for an endoscope, comprising:a tubular flexible tube substrate material having a flexibility; and
a resin layer covering the flexible tube substrate material,
wherein the resin layer is adhered to the flexible tube substrate material with an adhesive hardened,
wherein the adhesive hardened contains an ester-based polyurethane resin, which is a hardened resin of an adhesive for an endoscope,
wherein the adhesive for an endoscope contains an ester-based urethane polymer having a structure represented by the following Formula (1):

wherein R1 and R2 each independently represent an alkyl group, an alkoxy group, an alkylthio group, an aryl group, or a halogen atom; n1 and n2 each independently represent an integer of 0 to 4; X represents —C(Ra)(Rb)—, —O—, —S—, —SO2—, —C(?O)—, or —N(Rc)—; Ra and Rb each independently represent a hydrogen atom, an alkyl group, or an aryl group; Rc represents a hydrogen atom or an alkyl group; and Ra and Rb may be bonded to each other to form a ring, and
wherein a surface material of the flexible tube substrate material is an aramid fiber, and
wherein an equivalent ratio of an urethane segment with respect to a total of an urethane segment equivalent and an ester segment equivalent in the ester-based urethane polymer having a structure represented by the Formula (1) is at least 2% and less than 50%.

US Pat. No. 10,478,040

HANDLE ASSEMBLY FOR AN APPLIANCE DOOR

Haier US Appliance Soluti...

1. A handle assembly for an appliance door, the appliance door comprising an outer door and an inner door spaced apart by a door gap, the outer door defining a handle aperture, the handle assembly comprising:a handle frame mounted to the outer door over the handle aperture, the handle frame defining a pocket recess positioned within the door gap;
a pocket handle mounted to the handle frame within the pocket recess, the pocket handle comprising:
a horizontal arm extending from a rear of the pocket recess toward a front of the appliance door substantially along a horizontal direction; and
a grip extending from the horizontal arm substantially along a vertical direction, wherein a front surface of the grip sits flush with a front of the outer door.

US Pat. No. 10,478,034

CLEANING APPARATUS

SAMSUNG ELECTRONICS CO., ...

1. A cleaning apparatus, comprising:a cleaning apparatus body comprising a drive unit configured to generate a suction force;
a head unit through which air is introduced by the suction force;
a cleaning stick configured to extend from the head unit in a lengthwise direction; and
a dust collector comprising an inlet port, an outlet port spaced apart from the inlet port in the lengthwise direction, and a dust collecting flow path formed in the lengthwise direction from the inlet port to the outlet port,
wherein the dust collector comprises:
a cyclone unit comprising a cyclone space including the dust collecting flow path and configured to generate a cyclone stream from the air introduced through the head unit so that foreign matter is separated from the air that flows along the dust collecting flow path;
a dust collecting unit configured to communicate with the cyclone unit and comprising a dust collecting space to collect foreign matter from the cyclone unit;
a partition rib which partially partitions the dust collecting unit from the cyclone unit in a lengthwise direction of the dust collector;
a communication gap provided between an end of the partition rib and a discharge side of the dust collector through which the foreign matter separated from the air by the cyclone unit flows from the cyclone unit into the dust collecting unit; and
a prevention rib disposed in the dust collecting unit to be spaced apart from the communication gap a predetermined distance and disposed to face the communication gap to block foreign matter reversely flowing from the dust collecting unit into the cyclone unit,
wherein the cyclone unit comprises:
an inlet hole formed in a side of a tube extending from the inlet port to the inside of the cyclone space and formed so that air introduced from the inlet port is radially outwardly discharged from the tube, and
at least one cyclone generating rib formed spirally about the outer circumference of the tube to direct air introduced radially outward from the tube through the inlet hole to form a cyclone air stream,
wherein the cyclone space of the cyclone unit and the dust collecting space of the dust collecting unit are disposed inside a dust collector body, the dust collector body comprising an opening directly communicating with the cyclone space and the dust collecting space,
wherein a dust collector cover is disposed to open and close the opening of the dust collector body such that the cyclone space and the dust collecting space are accessible through the opening when the dust collector cover is open, and
wherein the prevention rib protrudes inwardly from the dust collector cover.