US Pat. No. 10,427,116

STIRRING WAND

Whirlpool Corporation, B...

1. A cooking appliance comprising:a housing including a heating element, an interior cavity and an underside that defines a receptacle;
a stirring tower having a tower supporting foot that selectively extends into the receptacle of the housing to define an engaged position where the receptacle of the underside covers and surrounds the tower supporting foot;
a tower mixing arm that extends over the tower supporting foot and is rotationally coupled to the stirring tower, the tower mixing arm operable between a mixing position defined by a tower drive system being in operable communication with the tower mixing arm, and an idle position defined by the tower drive system being out of operable communication with the tower mixing arm, wherein the tower mixing arm in the mixing position is positioned within the interior cavity of the housing when the stirring tower is in the engaged position; and
a lid that engages the housing and selectively encloses the interior cavity, wherein the lid selectively covers a portion of the tower mixing arm in the mixing position when the stirring tower is in the engaged position.

US Pat. No. 10,427,112

AERATION DEVICE FOR BIOREACTORS

SARTORIUS STEDIM BIOTECH ...

1. An aeration device for a bioreactor (25), comprising:a lower part (5) having an annular bottom wall (9), an outer circumferential wall (10) projecting up from the bottom wall (9), an inner circumferential wall (12) concentric with the outer circumferential wall (10) and projecting up from the bottom wall (9) and a circumferentially extending partition wall (11) concentric with the outer and inner circumferential walls (10, 12) and projecting up from the bottom wall (9) at a position between the outer and inner circumferential walls (10, 12) so that an outer aeration channel (7) is defined between the outer circumferential wall (10) and the partition wall (11) and an inner aeration channel (8) is defined between the partition wall (11) and the inner circumferential wall (12); and
an upper part (6) mounted to ends of the outer and inner circumferential walls (10, 12) and the partition wall (11) and opposed to the bottom wall (9) to define a housing (2) with the upper part (6) covering both the outer aeration channel (7) and the inner aeration channel (8), the upper part (6) having a lower surface facing into the outer aeration channel (7) and the inner aeration channel (8) and an upper surface opposite the lower surface, areas of the upper part (6) that cover the outer aeration channel (7) being formed with outer gas outlet openings (36) that are arranged circumferentially at equal intervals, each of the outer gas outlet openings (36) extending from the lower surface to the upper surface, all of the outer gas outlet openings (36) being spaced apart from one another at all locations on each outer gas outlet opening (36) from the lower surface to the upper surface and having a cross-sectional dimension at the upper surface that is the same for all of the outer gas outlet openings (36) and areas of the upper part (6) that cover the inner aeration channel (8) being formed with inner gas outlet openings (46) extending from the lower surface to the upper surface, minimum spacings between the inner gas outlet openings (46) being less than the intervals between the outer gas outlet openings (36), all of the inner gas outlet openings (46) being spaced apart from one another at all locations on each inner gas outlet opening (46) from the lower surface to the upper surface and having a cross-sectional dimension at the upper surface that is the same for all of the inner gas outlet openings (46) and that is different than the cross-sectional dimension of outer gas outlet openings (36), wherein the same cross-sectional dimension for all of the outer gas outlet openings (36) achieves a specified distribution of bubble sizes from the outer gas outlet openings (36) and the same cross-sectional dimension for all of the inner gas outlet openings (46) achieves a specified distribution of bubble sizes from the inner gas outlet openings (46) that is different from the specified distribution of bubble sizes from the outer gas outlet openings (36), the cross-sectional dimensions of the outer gas outlet openings (36) being at least three times the cross-sectional dimensions of the inner gas outlet openings (46).

US Pat. No. 10,427,111

GAS SEPARATION MEMBRANE, METHOD OF PRODUCING GAS SEPARATION MEMBRANE, GAS SEPARATION MEMBRANE MODULE, AND GAS SEPARATOR

FUJIFILM Corporation, To...

1. A gas separation membrane which satisfies any one of the following Conditions 1, 3, and 4,Condition 1: a gas separation membrane which has a resin layer containing a compound having a siloxane bond, in which the resin layer containing a compound having a siloxane bond satisfies the following Expressions 1 and 2,
0.9?A/B?0.55, and  Expression 1
B?1.7  Expression 2
in Expressions 1 and 2, A represents an O/Si ratio that is a ratio of the number of oxygen atoms relative to the number of silicon atoms contained in the resin layer containing a compound having a siloxane bond at a depth of 10 nm from the surface of the resin layer containing a compound having a siloxane bond, and B represents an O/Si ratio that is a ratio of the number of oxygen atoms relative to the number of silicon atoms in the surface of the resin layer containing a compound having a siloxane bond,
Condition 3: a gas separation membrane which has a resin layer containing a compound having a siloxane bond, in which a minimum value Si0 of the proportion of peaks of Si2+ and Si3+ to peaks of all Si in ESCA depth analysis of the resin layer containing a compound having a siloxane bond is in a range of 1% to 40%, and
Condition 4: a gas separation membrane which has a resin layer containing a compound having a siloxane bond, in which positron lifetime ?3 of a third component in a case where the positron is implanted at a strength of 1 keV from the surface of the resin layer containing a compound having a siloxane bond is in a range of 3.40 to 4.20 ns,
and which further comprises a porous support A and satisfies the following Condition 2,
Condition 2: a gas separation membrane which includes a porous support A; and a resin layer containing a compound having a siloxane bond positioned on the porous support A,
wherein the compound having a siloxane bond includes at least a repeating unit represented by the following Formula (2) or a repeating unit represented by the following Formula (3),
the resin layer containing a compound having a siloxane bond includes a region GLi present in the porous support B and a region GLe present on the porous support B,
the thickness of GLe is in a range of 50 to 1,000 nm,
the thickness of GLi is 20 nm or greater and the thickness of GLe is in a range of 10% to 350%, and
a difference between the content of the repeating unit represented by Formula (3) described above in 20 nm of the GLe surface layer and the content of the repeating unit represented by Formula (3) described above in 20 nm of the GLi surface layer is in a range of 30% to 90%,

in Formulae (2) and (3) described above, R11 represents a substituent, the symbol “*” represents a binding site with respect to # in Formula (2) or (3) described above, and the symbol “#” represents a binding site with respect to * in Formula (2) or (3) described above.

US Pat. No. 10,427,104

DOUBLE CROSSLINKED SODIUM ALGINATE/POLYVINYL ALCOHOL COMPOSITE NANOFILTRATION MEMBRANE AND PREPARATION METHOD THEREOF

KOREA RESEARCH INSTITUTE ...

1. A double crosslinked sodium alginate/polyvinyl alcohol composite nanofiltration membrane, comprising:a porous polymer support; and
a sodium alginate/polyvinyl alcohol blend coating layer formed on the porous polymer support and having a first crosslinking structure formed by complexation with divalent metal ions and a second crosslinking structure formed by acetalization with aldehyde groups;
wherein the porous polymer support may be any one selected from the group consisting of polysulfone, polyethersulfone, polyacrylonitrile, polyamide, polyimide, polyetherimide, polyetherether ketone, polyvinylidene fluoride, cellulose acetate and cellulose triacetate.

US Pat. No. 10,427,095

DEVICE, PROCESS, AND CATALYST INTENDED FOR DESULFURIZATION AND DEMERCAPTANIZATION OF GASEOUS HYDROCARBONS

START-CATALYST LLC, Mosc...

1. A process of desulfurization and demercaptanization of gaseous hydrocarbons, comprising:passing a mixture of gaseous hydrocarbons comprising a starting amount of hydrogen sulfide and mercaptans and an oxygen-containing gas through a reactor loaded with an organic solution of a catalyst,
wherein the catalyst comprises mixed-ligand complexes of transition metals,
wherein the catalyst comprises at least 60 percent by weight of a mixture of an amine and an amide, and at most 40 percent by weight of a mixture of cupric and/or ferric halogenides, and
producing an end product having a residual mercaptan concentration of 10 ppm or less and a residual hydrogen sulfide concentration of 10 ppm or less.

US Pat. No. 10,427,079

VARIABLE AIR FILTER ASSEMBLIES

FilterEasy, Inc., Raleig...

1. An air filter assembly for a heating and ventilation air conditioner (HVAC) system, the filter assembly comprising:a filter element having at least one variable dimension; and
a frame for engaging and supporting the filter element, the frame configured for being adjusted to accommodate the at least one variable dimension and secure the filter element therein,
wherein, the frame is positioned within an HVAC return to secure the filter element within an airflow of the HVAC system; and
wherein the filter element has a preformed fold pattern that facilitates reduction in two-dimensions.

US Pat. No. 10,427,072

DEVICE FOR SEPARATING A MEDIUM COMPRISING A MIXTURE OF A SOLID PORTION AND A FLUID PORTION

Cubility AS, Sandnes (NO...

1. A device for separating a medium comprising a mixture of a solid portion and a fluid portion comprising a liquid, wherein the device comprises:a filter arrangement comprising a displaceable filter element having a surface with a plurality of openings adapted to allow the fluid portion to be disposed through the openings while maintaining the solid portion on the surface of the filter element;
an inlet for feeding the medium to the filter element; and
an outlet for discharging the solid portion from the surface of the filter element;
wherein the device further comprises an obstruction having an elastic element extending towards the surface of the filter element and being adapted to contact the surface of the filter element and simultaneously interact with the medium while the solid portion is being separated from the fluid portion when the medium is being displaced from the inlet to the outlet;
wherein the device further comprises means for providing a stream of drive fluid through the filter element, thereby acting on the fluid with a pressure that pushes the fluid through the openings of the filter element while maintaining the solid portion on the surface of the filter element; and
wherein the obstruction is provided with the means for providing a stream of drive fluid through the filter element.

US Pat. No. 10,427,062

WHEEL ASSEMBLY FOR COUNTERING AN ACTING GRAVITATIONAL FORCE

MP Development Limited, ...

15. A wheel assembly for a toy car, the wheel assembly comprising:a roller having an axis of rotation;
a first wheel portion having a peripheral surface that extends entirely around the axis of rotation, wherein
the first wheel portion projects radially outward with respect to the axis of rotation,
the peripheral surface of the first wheel portion includes
a first circumferential portion having a peripheral outer surface extending partially around the peripheral surface of the first wheel portion and that is sticky, and
a second circumferential portion having a peripheral outer surface extending partially around the peripheral surface of the first wheel portion and that is devoid of the sticky surface, wherein the first and second circumferential portions of the first wheel portion adjoin each other and extend entirely around the axis of rotation; and
a second wheel portion having a peripheral surface that extends entirely around the axis of rotation, wherein
the second wheel portion projects radially outward with respect to the axis of rotation,
the peripheral surface of the second wheel portion includes
a first circumferential portion having a peripheral outer surface extending partially around the peripheral surface of the second wheel portion and that is sticky, and
a second circumferential portion having a peripheral outer surface extending partially around the peripheral surface of the second wheel portion and that is devoid of the sticky surface, wherein
the first and second circumferential portions of the second wheel portion adjoin each other and extend entirely around the axis of rotation,
the first and second wheel portions are spaced apart on the roller, and
the first and second wheel portions rotate upon rotation of the roller.

US Pat. No. 10,427,057

MULTI-USER SWING SET

Landscape Structures Inc....

1. A swing set comprising:a swing set frame;
a first swing comprising:
a first swing frame;
a first swing seat formed from a first belt that spans between two portions of the first swing frame;
a second swing comprising:
a second swing frame;
a second swing seat formed from a second belt that spans between two portions of the second swing frame;
a coupling bridge that couples the first swing to the second swing;
four swing coupling mechanisms, the first and second swing coupling mechanisms coupling the first swing to the swing set frame and the third and fourth swing coupling mechanisms coupling the second swing to the swing set frame; and wherein the first belt comprises a length such that a portion of the first belt hangs vertically lower than the coupling bridge, when the swing set is still.

US Pat. No. 10,427,052

VIDEO GAME PROCESSING PROGRAM, AND VIDEO GAME PROCESSING SYSTEM

KABUSHIKI KAISHA SQUARE E...

1. A non-transitory computer-readable medium including a video game processing program product configured to cause a server to control functions of a video game in response to an operation of a user,wherein the functions include:
an event participation managing function configured to receive participation in an event from at least one of users in the video game to constitute and manage a party, the at least one of the users participating in the event;
an initial level setting function configured to set a level of a player character in the event to a predetermined initial level regardless of a level of the player character indicating a degree of strength outside the event of the player character of the user who participates in the event, the initial level setting function being configured to cause the event to start after the level of the player character in the event is set to the predetermined initial level;
a level-up determining function configured to manage a predetermined condition to raise the level of the player character in the event, the level-up determining function being configured to determine whether the player character satisfies the predetermined condition or not;
a privilege giving function configured to give a privilege in the event to the player character or the user in a case where the level of the player character in the event reaches a predetermined level, the predetermined level being a level that the player character has already reached out of the event; and
a point giving function configured to give a point that raises a level of a player character out of the event to a player character, which participates in the event, of a user of whom a level of the player character out of the event does not reach an upper limit in a case where a predetermined condition to clear the event is satisfied, the predetermined condition being set to the event.

US Pat. No. 10,427,044

GAME MACHINE AND GAME PROGRAM

KONAMI DIGITAL ENTERTAINM...

1. A game machine comprising:an operation acceptor configured to accept an operation by a game player;
a display device having a display screen for displaying a game;
an output controller configured to display a reference indicator and a movement object, which moves toward the reference indicator, over the display screen, the output controller configured to change a display position of the reference indicator and a movement direction of the movement object, based on a change condition, wherein the change condition is that a predefined timing comes; and
an evaluator configured to evaluate the operation based at least in part on a first timing that the movement object reaches the reference indicator and a second timing that the operation acceptor accepts the operation.

US Pat. No. 10,427,035

GAME CONTROLLER WITH REMOVABLE TRIGGER ACCESSORY

MICROSOFT TECHNOLOGY LICE...

1. A game controller, comprising:a trigger-activation sensor;
a sensor-activation feature moveable relative to the trigger-activation sensor, wherein the trigger-activation sensor outputs a control signal based on a relative position of the sensor-activation feature and the trigger-activation sensor; and
a mounting platform including a trigger-retention feature configured to removably affix a selected removable trigger accessory to the mounting platform, the selected removable trigger accessory being one of a plurality of differently configured removable trigger accessories removably affixable to the mounting platform, the selected removable trigger accessory configured to change the relative position of the sensor-activation feature and the trigger-activation sensor based on finger manipulation of the selected removable trigger accessory when the selected removable trigger accessory is removably affixed to the mounting platform, and the mounting platform being configured to move with the selected removable trigger accessory responsive to finger manipulation of the selected removable trigger accessory when the selected removable trigger accessory is affixed to the mounting platform.

US Pat. No. 10,427,031

GAME SCORING AND TRACKING SYSTEM

Medal Sports (Taiwan) Cor...

1. A game scoring and tracking system, comprising:a playing surface;
a projectile configured for use on top of the playing surface;
a central unit located below the playing surface;
an at least one speaker communicatively coupled to the central unit;
a first end wall extending generally perpendicular from the playing surface;
a second end wall spaced apart from the first end wall;
a first side wall extending between the first end wall and the second end wall;
a second side wall spaced apart from the first side wall, extending between the first end wall and the second end wall;
a first corner illuminable indicia configured to connect the first end wall to the first side wall, the first corner illuminable indicia communicatively coupled to the central unit;
a second corner illuminable indicia configured to connect the second end wall to the first side wall, the second corner illuminable indicia communicatively coupled to the central unit;
a third corner illuminable indicia configured to connect the second end wall to the second side wall, the third corner illuminable indicia communicatively coupled to the central unit;
a fourth corner illuminable indicia configured to connect the first end wall to the second side wall, the fourth corner illuminable indicia communicatively coupled to the central unit;
a first goal located along the first end wall between the first corner illuminable indicia and the fourth corner illuminable indicia, the first goal configured to receive the projectile from the playing surface, and the first goal including a first at least one sensor communicatively coupled to the central unit; and
a second goal located along the second end wall between the second corner illuminable indicia and the third corner illuminable indicia, the second goal configured to receive the projectile from the playing surface, and the second goal including a second at least one sensor communicatively coupled to the central unit,
wherein the first at least one sensor detects the projectile entering the first goal and the second at least one sensor detects the projectile entering the second goal.

US Pat. No. 10,427,022

STRIKING ASSEMBLY

BIG HIT HOLDINGS INC., T...

1. A striking assembly for martial arts training comprising:a base plate having a first side and a second side opposite the first side, the base plate configured to be secured to a substrate external to the striking assembly;
a support unit comprising:
a support plate having a third side and a fourth side opposite the third side, the support plate coupled to the base plate and disposed such that the third side of the support plate is proximal to and faces the second side of the base plate; and
a post secured to the support plate, the post extending from the fourth side of the support plate in a direction away from the fourth side;
a striking unit comprising a main body having a recess for receiving a portion of the post of the support unit, the main body reversibly securable to the post, and a striking pad covering at least a portion of the main body, the striking pad configured to receive striking impacts;
three or more isolators coupling the support plate to the base plate, each isolator having a body being resiliently deformable, a first end of each isolator connected to the second side of the base plate, and a second end of each isolator connected to the third side of the support plate, the three or more isolators spaced such that one isolator is out of line with the other two isolators, the isolators resiliently deformable in response to a force originating from the striking impacts;
wherein in response to at least one of the striking impacts:
when the force is being applied during the at least one striking impact, the isolators are configured to resiliently deform in response to the force such that the striking unit and the support unit reversibly deflect relative to the base plate to create a deflection angle between a normal to the support plate and a normal to the base plate; and
when the force is discontinued at a conclusion of the at least one striking impact, the isolators are configured to resiliently return substantially to their undeformed dimensions to cause the striking unit and the support unit to rebound such that the normal to the support plate returns to being substantially parallel to the normal to the base plate.

US Pat. No. 10,426,972

METHODS OF TREATING MELANOMA

MALIGNANT MELANOMA, LLC, ...

1. A method for treating cutaneous malignant melanoma in a subject comprising irradiating cutaneous malignant melanoma on the skin of the subject with at least two fractions of radiation per day, said fractions of radiation being selected from about 100 centiGray (cGy) or about 135 centiGray (cGy) and said fractions being separated by a time interval of at least about 0.5 hour.

US Pat. No. 10,426,969

MAGNETIC FIELD STIMULATION

The McLean Hospital Corpo...

1. A system comprising:a pulse generator; and
a magnetic coil comprising a first element, an inner surface of the first element forming at least a part of a spherical surface, the first element being in electrical communication with the pulse generator,
wherein a parameter of the magnetic coil is selected such that the coil produces a gradient magnetic field proximate to a region at least partially enclosed by the spherical surface, the gradient magnetic field inducing an electric field in air up to about 50 V/m.

US Pat. No. 10,426,960

ANTENNA ASSEMBLY FOR SUPPLYING POWER TO AN IMPLANTABLE NEURAL STIMULATOR DEVICE

Stimwave Technologies Inc...

1. An antenna assembly, comprising:a metal layer configured to emit linearly polarized electromagnetic energy to a receiving antenna implanted underneath a subject's skin such that the receiving antenna implanted underneath the subject's skin is wirelessly powered by the linearly polarized electromagnetic energy emitted from the antenna assembly; and
a feed port configured to connect the antenna assembly to a signal generator such that the antenna assembly receives an input signal from the signal generator and then drives the metal layer using the input signal to emit the linearly polarized electromagnetic energy to the receiving antenna,
wherein the antenna assembly is less than 200 ?m in thickness, and
wherein the metal layer is operable as a dipole antenna with a reflection ratio of at least 6 dB, the reflection ratio corresponding to a ratio of a transmission power of the antenna assembly when driven by the input signal and a reflection power seen by the antenna assembly resulting from emission of the linearly polarized electromagnetic energy to the receiving antenna implanted underneath a subject's skin.

US Pat. No. 10,426,958

INTRANASAL STIMULATION FOR ENHANCED RELEASE OF OCULAR MUCINS AND OTHER TEAR PROTEINS

Oculeve, Inc., San Franc...

1. A method for increasing ocular mucin on an ocular surface of a subject, comprising:applying one or more active agents to the ocular surface prior to intranasally delivering an electrical stimulation to the subject, thereby increasing a density of goblet cells on the ocular surface, the one or more active agents comprising cyclosporine;
intranasally delivering the electrical stimulation to the subject after applying the one or more active agents to the ocular surface; and
stimulating release of the ocular mucin from the goblet cells,
wherein the increased density of goblet cells and the released ocular mucin from the goblet cells improves a condition of an eye of the subject.

US Pat. No. 10,426,903

AUTOMATIC TRIGGER MODULE AND ELECTRONIC CIGARETTE THEREOF

JOYETECH EUROPE HOLDING G...

4. An electronic cigarette, comprising:an automatic trigger module, comprising:
a sensor, having a first end and a second end which are opposite to each other;
a circuit board, having a first vent hole communicating with the first end of the sensor and a first connection;
a sealing seat, having a second vent hole communicating with the second end; and
a control board, having a second connection,
wherein the first end is located on the circuit board, and the second end is located in the second vent hole, and
wherein the automatic trigger module is detachably connected to the control board, and when the automatic trigger module is connected to the control board, the first connection and the second connection contact with each other to realize a transmission of signal.

US Pat. No. 10,426,892

MOTORIZED DRUG DELIVERY DEVICE

SHL Medical AG, Zug (CH)...

1. A motorized drug delivery device configured to administer at least one pre-set dose of a medicament contained within a medicament container, the delivery device comprising:a user activation system;
a motor;
a gear train operatively coupled to the user activation system and the motor;
a piston plunger system operatively coupled to the gear train, the piston plunger system comprising a piston plunger and at least one plunger extension for extending a length of the piston plunger;
wherein the piston plunger system is configured to act on a stopper contained within the medicament container to deliver at least one pre-set dose of medicament,
wherein the user activation system comprises a mechanical automatic reset activation system that automatically resets the drug delivery device after administration of the pre-set dose, and wherein the mechanical automatic reset activation system includes a dispense button operatively coupled to a hook release.

US Pat. No. 10,426,884

CARTRIDGES AND SYSTEMS FOR OUTSIDE-IN FLOW IN MEMBRANE-BASED THERAPIES

Novaflux Inc., Princeton...

1. An outside-in flow filtration cartridge, comprising:a housing;
a plurality of fibers contained inside said housing, at least some of said plurality of fibers being hollow and being made of semi-permeable membranes having respective fiber lumens and fiber exteriors;
a first fluid flow compartment comprising said fiber lumens of said hollow fibers; and
a second fluid flow compartment comprising an inter fiber space bordering said fiber exteriors,
wherein said housing comprises a first housing port near a first end of said housing, and a second housing port near a second end of said housing,
wherein said second fluid flow compartment comprises an orbital distributor in communication with said inter fiber space,
wherein said outside-in flow filtration cartridge comprises a lateral-circumferential flow redirector comprising an edge, said edge being located between one of said housing ports and said plurality of fibers, said edge facing in a direction toward said one of said housing ports, wherein said lateral-circumferential flow redirector comprises a first smoothly curved concave surface that extends from said edge and blends smoothly with a first circumferential direction of said orbital distributor, and a second smoothly curved concave surface that extends from said edge and blends smoothly with a second circumferential direction of said orbital distributor, and
wherein said outside-in flow filtration cartridge is constructed to flow blood in the inter fiber space bordering said fiber exteriors.

US Pat. No. 10,426,879

BLOOD PUMP WITH RESTART LOCKOUT

HeartWare, Inc., Miami L...

1. A control circuit for controlling operation of an implantable blood pump, the control circuit comprising:an interface;
a pump shutdown module in communication with the interface, the interface being configured to provide one or more inputs indicating at least from the group consisting of an operational error at the implantable blood pump and an adverse physiological state of a user of the implantable blood pump, the pump shutdown module being configured to cease operation of the implantable blood pump in response to the one or more inputs;
a pump restart module configured to resume operation of the implantable blood pump in response to a first pump restart input and a second pump restart input different from the first pump restart input, the first pump restart input and a second pump restart input being provided by the interface; and
a pump restart lockout module configured to initiate a pump lockout mode in response to a lockout input provided by the interface, the pump lockout mode:
preventing resumption of operation of the implantable blood pump in response to the first pump restart input; and
allowing resumption of operation of the implantable blood pump in response to the second pump restart input.

US Pat. No. 10,426,878

CENTRIFUGAL BLOOD PUMP SYSTEMS

Flow Forward Medical, Inc...

1. A centrifugal blood pump system to persistently increase the overall diameter of veins wherein the blood pump is configured to pump blood into a peripheral vein, the centrifugal blood pump system comprising:a) a centrifugal blood pump comprising:
i) a pump housing comprising:
a) an inlet comprising an inflow diffuser to receive blood and direct blood onto an impeller, the inflow diffuser further comprising a top pivot bearing and a bottom pivot bearing, wherein a protrusion extends from the pump housing into the inlet and wherein the protrusion comprises a recess that accepts and supports at least a portion of a stationary portion of the top pivot bearing;
b) an impeller casing comprising a recess that accepts and supports at least a portion of the stationary portion of the bottom pivot bearing; and
c) an outlet;
ii) an impeller suspended within the pump housing and disposed between the stationary portions of the top and bottom pivot bearings, the impeller having:
a) A top impeller pivot shaft comprising a rotating portion of the top pivot bearing that is configured to engage the stationary portion of the top pivot bearing;
b) A bottom impeller pivot shaft comprising a rotating portion of the bottom pivot bearing that is configured to engage the stationary portion of the bottom pivot bearing;
c) a plurality of blades on the top surface of the impeller and extending radially away from a center of the impeller, the blades to direct blood received from the inlet to the outlet when the pump is in operation;
d) a plurality of bore holes extending parallel to a central axis of the impeller from a bottom surface through the impeller to a top surface; and
e) at least one magnet mechanically engaged to the impeller;
iii) an electric motor to magnetically engage the at least one magnet, wherein the electric motor rotates the at least one magnet and the impeller when the pump is in operation;
b) an inflow conduit having an inner diameter of 2-6 mm, having a first end and a second end, where the first end is configured to make a fluid connection to the inlet and the second end is configured for insertion into the lumen of a donating vein;
c) an outflow conduit with an inner diameter of 2-6 mm, having a first end and a second end, where the first end is configured to make a fluid connection to the outlet and the second end is configured for insertion into the lumen of an accepting vein; and
d) a control device for controlling the speed of the impeller, the control device including a processor, a memory, a battery, and a cable for electrically connecting the control device to the centrifugal pump, wherein the processor is configured for controlling the impeller speed to maintain a blood pumping rate between 50 mL/min and 1500 mL/min for at least 7 days.

US Pat. No. 10,426,875

WOUND CLEANSING APPARATUS IN-SITU

1. A negative pressure wound therapy system, comprising:a wound dressing comprising:
a backing layer comprising an opening and a proximal, wound-facing face and a distal face;
a lower permeable layer configured to contact a wound; and
a chamber between the backing layer and the lower permeable layer; and
a resiliently flexible filler positioned within the chamber, the resiliently flexible filler comprising an absorbent material configured to retain wound exudate within the chamber;
a fluid outlet conduit configured to provide fluid communication between a negative pressure source and the wound dressing, the fluid outlet conduit being in fluid communication with the chamber of the wound dressing; and
a connector attached to the backing layer and forming a seal around the opening in the backing layer, wherein the connector is configured to connect the fluid outlet conduit to the wound dressing; and
a porous material positioned in the flow path between the chamber and the negative pressure source and configured to prevent passage of the wound exudate from the chamber into the fluid outlet conduit.

US Pat. No. 10,426,874

WOUND MANAGEMENT ASSEMBLY AND NEGATIVE PRESSURE WOUND THERAPY SYSTEM

APEX MEDICAL CORP., New ...

1. A wound management assembly for promoting removal of fluid from a wound, comprising:a housing comprising an inlet portion, an outlet and a side wall;
an exudate collector received in the housing; and
a gap defined between the housing and the exudate collector to form a channel for fluid passage;
wherein the fluid passes into and through the exudate collector and radially enters the channel;
wherein the housing defines a chamber therein for receiving the exudate collector, and the inlet portion and the outlet are in communication with the chamber; and
wherein the side wall encompasses the exudate collector, and the exudate collector is surrounded by the channel.

US Pat. No. 10,426,860

AROMA DIFFUSER AND OIL SUPPLY METHOD

Shenzhen NearbyExpress Te...

1. An aroma diffuser, comprising:a main body, provided therein with a liquid storage chamber, the liquid storage chamber being configured to store a liquid; and
an oil storage tube configured to store an essential oil,
wherein when the aroma diffuser works, a bottom portion of the oil storage tube is in fluidic communication with the liquid storage chamber, allowing the essential oil in the oil storage tube to flow from the bottom portion of the oil storage tube into the liquid storage chamber as the liquid in the liquid storage chamber is being consumed.

US Pat. No. 10,426,856

DECONTAMINATION SYSTEM

AIREX CO., LTD., Nagoya-...

1. A decontamination system for decontaminating, with respect to one or more rooms targeted to be decontaminated, an inside of each room targeted to be decontaminated, by using decontamination gas, the decontamination system comprising compressed air-generating means for generating compression air; decontamination solution-supplying means for supplying decontamination solution;mixed gas-liquid adjusters to adjust, with respect to each room targeted to be decontaminated, decontamination mixed gas-liquid obtained by respectively mixing the compression air and the decontamination solution;
gas generators to gasify the mixed gas-liquid to generate decontamination gas;
air supplying pipes which communicate from the compressed air-generating means up to each of the mixed gas-liquid adjuster;
decontamination solution supplying pipes which communicate from the decontamination solution-supplying means up to each of the mixed gas-liquid adjuster; and
mixed gas-liquid supplying pipes which communicate from each mixed gas-liquid adjuster up to a corresponding gas generator of the gas generators,
characterized in that the compressed air-generating means, the decontamination solution-supplying means, and each respective mixed gas-liquid adjusters are arranged at positions which are spaced from each room targeted to be decontaminated, and each of the gas generators is arranged near or in each of the one or more rooms targeted to be decontaminated that corresponds thereto, and
a conveyance distance of each mixed gas-liquid supplying pipe with respect to each room targeted to be decontaminated is thereby longer than a conveyance distance of each of the decontamination solution supplying pipes that corresponds thereto.

US Pat. No. 10,426,853

APPARATUS TO CONTROL REACTION OF PEROXIDE AND ALKALINE

1. An apparatus for supplying a peroxide composition and an alkaline composition simultaneously for removal and destruction of microbiological and organic contamination on a surface comprising:a power module;
a means to activate the power module;
a pump connected to the power module;
a pump intake line, wherein one end of the pump intake line is connected to the pump and the other end is connected to at least one pump check valve system, wherein each pump check valve system further comprises:
a pump check valve, wherein the pump check valve is attached to the pump intake line and a check valve line,
a solenoid valve, wherein the solenoid valve is connected to the check valve line and composition input line,
a composition pick up tube, wherein the composition pick up tube is connected to the composition intake line and an input check valve, and the input check valve is connected to a filter screen, wherein the input check valve and filter screen are within a reservoir, and wherein the reservoir of at least one pump check valve system contains hydrogen peroxide;
a pump discharge line connected to the pump;
an injector connected to the pump discharge line;
an injector intake line, wherein the injector intake line is independent of the pump intake line and the at least one pump check valve system, and one end of the injector intake line is connected to the injector and the other end is connected to an injector valve system, wherein the injector valve system is independent of the pump intake line and the at least one pump check valve system, and the injector valve system further comprises:
a solenoid valve, wherein the solenoid valve is attached to the injector intake line and a composition intake line,
a composition pick up tube, wherein the composition pick up tube is connected to the composition intake line and an input check valve, and the input check valve is connected to a filter screen, wherein the input check valve and filter screen are within an injector reservoir that contains an alkaline composition;
a metering device, wherein the metering device is located at the intersection of the injector and the injector intake line;
an injector output line, wherein one end of the injector output line is connected to the injector and the other end is connected to a spray line;
a one way check valve, wherein the one way check valve is connected to the spray line and a handheld spray wand,
wherein the power module further comprises a means to activate the solenoid valves individually and a means to activate the pump.

US Pat. No. 10,426,850

COLLAGEN MIMETIC PEPTIDES FOR TARGETING COLLAGEN STRANDS FOR IN VITRO AND IN VIVO IMAGING AND THERAPEUTIC USE

THE JOHNS HOPKINS UNIVERS...

1. A collagen mimetic peptide (CMP) having the formula:L-S-[Gly-X-Y]n-Gly-X-Y-[Gly-X-Y]n; wherein
L is IRDye-800CW or IRDye 680RD;
S is aminohexanoic acid;
X is proline;
Y is hydroxyproline;
Gly is glycine; and
n is 4.

US Pat. No. 10,426,842

TARGETED NANOPARTICLE CONJUGATE AND METHOD FOR CO-DELIVERY OF SIRNA AND DRUG

The Curators of the Unive...

1. A nanoparticle conjugate comprising a small interfering RNA (siRNA) covalently linked to an antibody that is bonded to the surface of a gelatin nanoparticle that physically encapsulates a drug, wherein one end of siRNA is coupled to an epidermal growth factor receptor (EGFR) targeting monoclonal antibody via a thio-ether bond, and a lysine functional group present on the antibody is bridged with carboxyl groups present on the gelatin nanoparticle.

US Pat. No. 10,426,837

COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS

Sage Therapeutics, Inc., ...

1. A compound of Formula (I-c):
wherein:
n is 0, 1, 2, 3, 4, or 5;
Ring A is aryl or heteroaryl;
R3A is C1-6 alkyl;
R1 is hydrogen, C1-3alkyl, C2-6 alkenyl, or C3-6 carbocyclyl;
R2 is absent or hydrogen;
Ra is halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(O)RA, —C(O)ORA, —C(O)NRBRc, —S(O)2RD, or —ORY, wherein RY is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(O)RA, —C(O)ORA, —C(O)NRBRc, or —S(O)2RD;
RA is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
each of RB and Rc is independently hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, or taken together with the atom to which they are attached form a ring; and
RD is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl.

US Pat. No. 10,426,762

INHIBITORS OF HEPATITIS C VIRUS POLYMERASE

COCRYSTAL PHARMA, INC., ...

1. A compound according to Formula I:
or a pharmaceutically acceptable salt thereof,
wherein:
X is —CH2— and Y is —NR1—;
R1 is —C5-6hydroxyalkyl, —S(O)2—C0-4alkyl-RO, —C0-4alkyl-RO, —C0-3alkyl-C(O)—C0-4alkyl-RO, —C0-3alkyl-C(O)O—C0-4alkyl-RO;
wherein:
RM and RN are independently hydrogen, —C1-4alkyl, or RM and RN together with the atoms to which they are attached can form a 4- to 6-membered ring; and
RO is (a) a 5- to 7-membered cycloalkyl, substituted with a —C1-3alkyl, aryl, —O-aryl, or —NRMRN moiety, (b) a 7-membered cycloalkyl optionally substituted with a hydroxyl, or (c) a 6- to 10-membered aryl, monocyclic or bicyclic, and substituted with one to three moieties independently selected from —C1-4alkyl, halogen, —NRMRN, —C1-4haloalkyl, —C1-4alkoxy, —C1-4hydroxyalkyl, cyano, —O-aryl, and aryl, provided that at least one such substitution is —C1-4alkoxy, —C1-4hydroxyalkyl, cyano, or —O-aryl;
R2 is —C1-5alkyl optionally substituted with 1-5 halogens, —C1-5alkoxy, —C5-7cycloalkyl-C0-3alkyl in which the alkyl is optionally substituted with 1-3 halogens, —C1-4alkyl-C3-5cycloalkyl, or phenyl optionally substituted with 1 or 2 halogens or —C1-3alkyl groups optionally substituted with 1-3 halogens;
R3 is —RA—RB;
wherein RA is a phenyl moiety optionally substituted with one or two Z, in which each Z is independently halogen, —C1-3alkyl, —C1-3haloalkyl, —C1-3alkoxy, or cyano; and
wherein RB is —N(RU)C(O)—RQ;
wherein RQ is a thiazolyl, optionally substituted with one or two RZ, in which each RZ is independently —C1-3alkyl, —C1-3alkoxy, or —NRMRN;
RS and RT are each independently hydrogen or —C1-4alkyl, or one of RS and RT is hydrogen and the other is —C(O)-5- to 9-membered aryl; and
RU is hydrogen or —C1-4alkyl;
provided that, when RA is phenyl, then RB appears at the para or meta position relative to the thiophene moiety; and
R4 is hydrogen, —C1-4alkyl, —C1-4alkyl-OC(O)O—C1-4alkyl, —C1-4alkyl-OC(O)—C1-4alkyl, —C1-4alkyl-OC(O)O—C3-6cycloalkyl, 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl-, —C0-3alkyl-C5-6aryl, or —C1-4alkyl-NRVRW; and
RV and RW are independently hydrogen or —C1-4alkyl.

US Pat. No. 10,426,732

RAPIDLY DISINTEGRATING TABLET, AND METHOD FOR PRODUCING SAME

DAICEL CORPORATION, Osak...

1. An orally disintegrating tablet having a specific surface area of from 1.60 to 2.50 mm2/mg, a weight of from 10 to 30 mg, and a diameter of 4 mm or less, which comprises a disintegrative particulate composition containing crystalline cellulose in an amount of 1% to 40% by weight of a total weight of the composition, and has a disintegration time in water of 7 seconds or less and an oral disintegration time of 5 seconds or less.

US Pat. No. 10,426,710

SYSTEM, METHOD AND APPARATUS FOR TEETHING DEVICE

Teetherpop, LLC, Austin,...

1. A teething device, comprising:a base having a handle on an end and a coupling on an opposite end, a y-axis extending through both the handle and the coupling, an x-axis and a z-axis extending perpendicular to the y-axis and to each other, and the base and coupling being formed from a first material having a first hardness;
a reservoir configured to contain a liquid therein, the reservoir having a coupling sealed to the base coupling and configured to provide a watertight seal, the reservoir has apertures that are the only apertures formed therein, the apertures consist of slits that are repeatably self-sealing, all of the slits are located only along a terminal distal end of the reservoir, each slit has a default position wherein each slit is configured to be resiliently biased to automatically return to be substantially closed to essentially prevent the liquid from flowing therethrough, and a flexed position wherein each slit is configured to be opened by squeezing to allow the liquid to flow therethrough;
the base further comprises a protrusion that extends into the reservoir, and the protrusion is spaced apart and free of contact with the reservoir;
the reservoir is formed from a second material having a second hardness that is softer than the first hardness, such that the reservoir is configured to be used as a teething device and capable of being frozen; and
the reservoir comprises a shape that is parabolic in a first plane of reference defined by the x-axis and the y-axis, and the reservoir has a second shape that is elongated and generally elliptical in a second plane of reference defined by the x-axis and the z-axis, such that an entirety of the reservoir is generally human tongue-shaped.

US Pat. No. 10,426,704

PRE-DOSED APPLICATORS AND PACKAGING THEREFOR

Centrix, Inc., Shelton, ...

1. A package for containing and dosing pre-dosed applicators comprising:a container having a bottom and a top with a container depth from the bottom to the top of said container;
an absorbent pad placed adjacent the bottom, said absorbent pad having an initial dry compressed thickness and a subsequent expanded wet thickness;
a solution containing a material placed on the absorbent pad;
a plurality of applicators, each of said plurality of applicators having an applicator length and an absorbent end placed in the container, wherein the absorbent end is placed adjacent said absorbent pad;
wherein the applicator length combined with the initial dry compressed thickness of said absorbent pad is less than the container depth and the applicator length combined with the subsequent expanded wet thickness of said absorbent pad is greater than the container depth; and
a lid placed over the top of the container.

US Pat. No. 10,426,699

DEVICE AND METHOD FOR DOCKING A VIAL WITH A CONTAINER

Gary L. Sharp, Naples, F...

1. A device for docking a vial with an adapter comprising:a base comprising a first and second base member;
a vertical support extending upwardly from the base;
a platform positioned above the base;
a first aperture in the platform sized to accept the adapter;
a second aperture in the platform arranged opposite the first aperture;
a head support extending from the vertical support;
a lever arm hingedly fastened to the vertical support; and
a plunger adapted to slide within the head support and attached to the lever arm such that rotation of the lever arm causes the plunger to travel vertically;
wherein the first and second aperture each have an opening, wherein the openings are positioned along opposing edges of the platform;
wherein each of said first and second base members comprise an interior channel located along an interior edge of the respective base member to removably support said platform such that the opening associated with the first aperture or the opening associated with the second aperture may selectively be exposed.

US Pat. No. 10,426,688

SYSTEMS AND METHODS FOR TRANSFERRING EXOSKELETON TRAJECTORY SEQUENCES

Ekso Bionics, Inc., Rich...

1. A method for transferring an exoskeleton trajectory sequence using at least one server remote from a first device including a controller, the method comprising:transferring, with the at least one server, the exoskeleton trajectory sequence to the first device where the exoskeleton trajectory sequence is validated, wherein validating the exoskeleton trajectory sequence includes performing a safety check in which a determination is made with the controller as to whether the exoskeleton trajectory sequence is safe for use with exoskeletons, the first device includes a first exoskeleton, the safety check includes performing a physical test of the exoskeleton trajectory sequence using the first exoskeleton, performing the physical test includes causing the first exoskeleton to move and receiving data from a sensor of the first exoskeleton, and causing the first exoskeleton to move includes causing the first exoskeleton to perform the exoskeleton trajectory sequence; and
receiving, from the first device, the exoskeleton trajectory sequence or confirmation that the exoskeleton trajectory sequence is valid with the at least one server, wherein the exoskeleton trajectory sequence includes prescribed positions of joints of an exoskeleton over time or a force profile of actuators of the exoskeleton.

US Pat. No. 10,426,687

MECHANICAL LINKAGE

Moog BV, Nieuw-Vennep (N...

1. A rehabilitation apparatus comprising:a force provider;
a recipient object, wherein the recipient object is a body part support; and
a linkage configured to transfer a force from the force provider to the recipient object, the linkage comprising a first link and a second link;
the first link having a first rotational joint defining a first link axis, and a second rotational joint defining a second link axis, the first and second link axes being at a first link angle to each other, which first link is pivotably attached to the recipient object for rotation about the first axis; and,
the second link having a third rotational joint defining a third link axis, and a fourth rotational joint defining a fourth link axis, the third and fourth link axes being at a second link angle to each other, the second link being pivotably attached to the first link such that the second and third link axes coincide, the second link being pivotably mounted at the fourth link axis to transfer a force from the force provider,
in which the first, second, third and fourth axes intersect at a predetermined point such that the recipient object can rotate about the predetermined point by articulation of the linkage;
in which the first and second link angles are each less than 45 degrees; and
in which the body part support is a foot support, and the force provider is configured to exert the force in a fore-aft direction of a subject's foot in use.

US Pat. No. 10,426,685

MOBILE PATIENT BED

OPTIMEDICA CORPORATION, ...

1. A mobile patient bed for moving a patient between at least two locations during a medical procedure, the mobile patient bed comprising:at least one user control configured receive user commands;
a communication device configured to selectively couple the mobile patient bed to at least one medical system;
at least one processor configured to:
in response to the mobile patient bed being coupled to the at least one medical system, receive a medical system command via the communication device and process the medical system command, and refrain from processing user commands received from the at least one user control; and
in response to the mobile patient bed not being coupled to the at least one medical system, receive and process a user command received from the at least one user control;
a seat; and
a plurality of motors configured to move the seat in a plurality of degrees of freedom, wherein the moving of the seat is performed in response to the processed medical system command or the processed user command.

US Pat. No. 10,426,683

PATIENT REPOSITIONING SYSTEM FOR BARIATRIC BED

Hillenbrand Management Co...

1. A patient repositioning system comprising:a mattress having a head end and a foot end and an upper surface;
a sheet residing on the upper surface;
a drive mechanism operatively coupled to the sheet and adapted to pull the sheet toward the head end, thereby to reposition a patient supported on the mattress;
a housing holding the drive mechanism; and
the mattress further comprising a body portion and at least one side bolster operatively coupled along one longitudinal side of the body portion, thereby to widen the upper surface of the mattress so as to accommodate bariatric dimensions,
wherein the mattress body portion comprises at least one row of one or more retainers substantially covered by the operatively coupled side bolster, and
wherein the operatively coupled side bolster comprises voids located on a vertically oriented inner surface thereof which abuts against the adjacently located mattress body portion, the voids corresponding to a like number of retainers on the abutting surface of the mattress body portion, whereby the voids facilitate proper positioning and alignment of the side bolster.

US Pat. No. 10,426,681

TOPPER FOR A PATIENT SURFACE WITH FLEXIBLE FABRIC SLEEVES

Hill-Rom Services, Inc., ...

1. A patient support apparatus comprisinga cushion including a plurality of inflatable bladders adapted to support a patient,
a topper arranged to extend over a top side of the cushion and configured to conduct air along an actively-cooled region of the top side of the cushion from a flexible fabric sleeve arranged to extend in a vertical direction between adjacent individual ones of the plurality of inflatable air bladders included in the cushion at a location between a left and a right side of the cushion, the flexible fabric sleeve being in pneumatic communication with the actively-cooled region to provide at least a portion of a fluid distributor for carrying air or other gasses to the actively cooled region, and
a lower ticking and an upper ticking that cooperate to encase the cushion and the topper.

US Pat. No. 10,426,677

RECLINING TRANSPORT CHAIRS

The UAB Research Foundati...

1. A wheelchair configured to recline and incline forward, said wheelchair comprising:(a) a base frame having a first pivot axis;
(b) at least two wheels rotationally mounted to said base frame;
(c) a seat assembly and a footrest assembly configured to pivot about said first pivot axis from a first seated position to an inclined seated position; and
(d) a leg rest assembly pivotally coupled to said base frame and configured to pivot about a second pivot axis to elevate in unison with the seat assembly when said seat assembly reclines but independent of said footrest assembly.

US Pat. No. 10,426,675

ANTI-COLLISION SYSTEM FOR PERSONAL MOBILITY SCOOTERS

1. A system for reducing encounters between a mobility scooter and objects or ledges, wherein the mobility scooter includes a controller that is configured to receive movement signals from electronic components of the mobility scooter via a first multi-pin connector, the controller configured to control movement based on the movement signals, the system comprising:a second multi-pin connector configured to couple with the first multi-pin connector and intercept a first movement signal transmitted from a first electronic component of the mobility scooter to the controller of the mobility scooter, the first movement signal indicating (i) a movement variable and (ii) a direction; and
an anti-collision circuitry configured to communicatively couple with (1) the second multi-pin connector, and (2) the controller via the first multi-pin connector or the second multi-pin connector:
receive the first movement signal from the second multi-pin connector,
receive, via the second multi-pin connector, proximity data from one or more proximity sensors,
perform a determination as to whether the proximity data indicates that the mobility scooter is within a proximity threshold, wherein the proximity threshold corresponds to the movement variable,
in response to determining the received proximity data indicates the mobility scooter is within the proximity threshold, overriding the first movement signal and providing one or more control signals to the controller via the second multi-pin connector and the first multi-pin connector, wherein the one or more control signals are relayed to at least a throttle, a motor or a brake of the mobility scooter; and
in response to determining the received proximity data indicates the mobility scooter is not within the proximity threshold, allowing the first movement signal to pass to the controller.

US Pat. No. 10,426,673

PLATFORM ENTRANCE GATE SAFETY BARRIER FOR A MOBILITY VEHICLE LIFT

The Braun Corporation, W...

16. A lift platform assembly configured to be coupled to a floor and transition a lift platform between a stowed position and a ground level position, comprising:one or more arms coupling the lift platform to the floor;
a gate mount pivotally coupled to the lift platform along a first platform side, the gate mount defining both a mount pivot axis and a gate axis therethrough;
a retention gate pivotally coupled to the gate mount;
a roll stop plate pivotally coupled to the lift platform at an outboard end and extending between the first platform side and a second platform side; and
a latch assembly coupled to the lift platform at the second platform side and configured to selectively couple the retention gate to the second platform side;
wherein when the latch assembly is not coupled to the retention gate and the lift platform is in the ground level position, the retention gate is pivotable about the gate axis away from the second platform side.

US Pat. No. 10,426,671

METHOD FOR MANUFACTURING A NONWOVEN HAVING IMPROVED SOFTNESS SIGNALS

PFNonwovens LLC, Hazleto...

1. A method of manufacturing a nonwoven web comprising the steps of:forming a nonwoven web substantially comprised of continuous fibers;
applying a bonding pattern to said nonwoven web using a smooth roll and a calender roll wherein said bonding pattern comprises a pattern having unbonded areas; and
subjecting the side of said nonwoven web contacted by said smooth roll to a hydroengorgement treatment at a pressure of between 25 and 75 bars and a total energy of about 0.01-0.04 kwhr/kg.,
wherein said continuous fibers are comprised of between 97% and 98.5% by weight of an olefin resin comprising substantially of polypropylene and between 1.5% and 3% by weight of a whitener.

US Pat. No. 10,426,651

NASAL INSERTS

Sanostec Corporation, Be...

1. A device for nasal insertion comprising:an open-ended tubular element (a) extending along a central tube axis between a first end and a second end, the first end being larger than the second end, and (b) defining a receptacle formed through a sidewall of the tubular element between the first end and the second end; and
a nodule comprising an internal face, a rounded external face, and a stalk extending from the internal face and terminating in an anchor sufficiently larger than the receptacle and sufficiently deformable as to be pressed through the receptacle to affix the nodule to the tubular element.

US Pat. No. 10,426,647

ORTHOPEDIC DEVICE

OSSUR ICELAND EHF, Reykj...

1. An orthopedic device comprising:a footplate arranged to be positioned beneath a foot of a wearer, the footplate defining an anterior end, a first side, and a second side opposite the first side, the second side including a first guide;
an upright support having a semi-rigid configuration and arranged to extend along a side of an ankle of the wearer, the upright support including a distal portion connected to the first side of the footplate and a proximal portion arranged to move toward and away from the anterior end of the footplate;
a cuff having a flexible configuration including a first portion affixed to the proximal portion of the upright support, and a second portion extending over the second side of the footplate and arranged to move toward and away from the second side of the footplate; and
a motion control system including a dial-tensioning control mechanism attached to the second portion of the cuff above the second side of the footplate, and at least one tensioning element including first and second ends affixed to the dial-tensioning control mechanism and passing through the first guide of the footplate toward a second guide defined on the dial-tensioning control mechanism that directs the at least one tensioning element back towards the footplate,
wherein the at least one tensioning element is arranged to allow movement of the second side footplate in a direction away from the cuff until the at least one tensioning element becomes taut and to slide through the first guide on the footplate and to slide through the second guide on the dial-tensioning control mechanism when the proximal portion of the upright support moves toward and away from the anterior end of the footplate.

US Pat. No. 10,426,639

MULTI-CHAMBER VACUUM PUMP

Otto Bock HealthCare LP, ...

1. A vacuum pump for a prosthetic device, comprising:a housing having an inner wall;
a piston having an outer diameter and being positioned within the housing;
a shaft having an inner surface and being positioned between the inner wall of the housing and the outer diameter of the piston;
a first evacuation chamber positioned between a top surface of the piston and the inner surface of the shaft, the first evacuation chamber having a variable volume as the shaft moves axially relative to the piston and the housing, the first evacuation chamber being fluidly connectable to a socket of the prosthetic device through a first valve and fluidly connected to atmosphere through a second valve;
a second evacuation chamber positioned between a bottom surface of the piston and the inner surface of the shaft, the second evacuation chamber having a variable volume as the shaft moves axially relative to the piston and the housing, the second evacuation chamber being fluidly connectable to the socket through a third valve and fluidly connected to atmosphere through a fourth valve.

US Pat. No. 10,426,637

EXOSKELETON ANKLE ROBOT

THE HONG KONG POLYTECHNIC...

1. An exoskeleton ankle robotic device comprising:a leg brace;
a foot piece pivotally coupling to said leg brace at or proximal to an ankle position;
an actuator coupling to said leg brace and said foot piece through an articulated joint, said actuator receiving power from a power source and generating a torque to drive said articulated joint to produce relative rotatory movement between said leg brace and said foot piece;
a gear transmission system coupling to said actuator and said articulated joint to transmit rotation axis of the actuator;
at least one force sensor for measuring force applied to the foot piece;
motion sensors comprising an accelerometer for measuring linear acceleration along a shank of a user and a gyroscope for measuring angular velocity of the shank of the user; and
a controller configured to:
receive the force applied to the foot piece for determining a gait phase of the user;
receive the linear acceleration and the angular velocity, both of which are measured at the gait phase; wherein the gait phase is either a swing phase or a pre-swing phase;
compare the linear acceleration and the angular velocity with a set of predetermined thresholds to classify a walking condition of the user using a control algorithm, the set of predetermined thresholds being determined under different walking conditions; and
send a command to control said actuator for actively assisting a gait of the user under the walking condition.

US Pat. No. 10,426,636

ARTIFICIAL FINGER

OTTO BOCK HEALTHCARE PROD...

1. An artificial finger for prosthetics and gripping technology, comprising:a base;
a first finger member mounted on the base in an articulated manner;
a secondary member mounted on the first finger member in an articulated manner;
a drive for adjusting the secondary member relative to the first finger member and the first finger member relative to the base;
a deflection member displaceably mounted to at least one of the first finger member and the secondary member and biased against displacement when the drive is operated;
a traction member coupled to the drive and guided on the deflection member;
a first reset element provided for resetting the first finger member relative to the base and a second reset element for resetting the secondary member relative to the first finger member, and the first finger member is acted upon with a resetting force from the first reset element which differs from a resetting forcing acting upon the secondary member from the second reset element;
wherein moving a position of the deflection member along the length of the artificial finger adjusts a position of a point arranged on at least one of the first finger member and the secondary member, wherein application of an external force resulting from grasping an object using the artificial finger leads to either a flexion movement or a hyperextension movement of the secondary member relative to the first finger member depending on a location of the object along a length of the artificial finger distal or proximal of the point, and depending on at least one of a size of the object and a shape of the object.

US Pat. No. 10,426,635

MEDICAL FORCE MEASURING SYSTEM

Aesculap AG, Tuttlingen ...

1. Medical force measuring system for measuring a force that is effective between two prosthesis parts of a joint prosthesis, the two prosthesis parts being connected to one another in an articulated manner, the joint prosthesis comprising a ball joint or a partial component thereof, which force measuring system comprises:a measuring instrument, the measuring instrument comprising:
a sample joint element having a sample joint surface, the sample joint element being formed in correspondence with a first joint element that forms a part of the ball joint and comprises a joint surface that is formed in correspondence with the sample joint surface and is moveable into engagement therewith for forming a sample ball joint, and
an indicating device arranged or formed on the measuring instrument which cooperates with the sample joint element for indicating a force that is effective on the sample joint surface or a partial component of the force that is effective on the sample joint surface,
wherein:
the measuring instrument further comprises a coupling element;
the medical force measuring system further comprises a medical instrument which is couplable to the measuring instrument,
the medical instrument further comprises an instrument coupling device,
the instrument coupling device comprises a clamping element which is moveable into engagement in at least one of a force-locking and a positive-locking manner with a prosthesis part or the medical instrument on the one hand and with the coupling element on the other hand, and
the clamping element is in the form of a clamping ring which, in a clamping position, engages in at least one of (a) an annular groove in the prosthesis part or in the medical instrument on the one hand, and (b) an annular groove in the coupling element on the other hand.

US Pat. No. 10,426,633

ZERO-PROFILE EXPANDABLE INTERVERTEBRAL SPACER DEVICES FOR DISTRACTION AND SPINAL FUSION AND A UNIVERSAL TOOL FOR THEIR PLACEMENT AND EXPANSION

Moskowitz Family LLC, Ro...

1. An expandable intervertebral fusion device comprising:a first movable portion extending from a first end to a second end, wherein the first movable portion has first and second end portions positioned at the first and second ends, respectively, and has first and second side portions extending between the first and second end portions, wherein the first movable portion has a first vertebral body engagement surface and has a first interior surface positioned on an opposite side of the first movable portion than the first vertebral body engagement surface;
a second movable portion extending from a third end to a fourth end, wherein the second movable portion has third and fourth end portions positioned at the third and fourth ends, respectively, and has third and fourth side portions extending between the third and fourth end portions, wherein the second movable portion has a second vertebral body engagement surface and has a second interior surface positioned on an opposite side of the second movable portion than the second vertebral body engagement surface, wherein the first movable portion is aligned with the second movable portion such that the first end of the first movable portion is axially aligned with the third end of the second movable portion and the second end of the first movable portion is axially aligned with the fourth end of the second movable portion, wherein the first end portion of the first movable portion is hingedly connected to the third end portion of the second movable portion such that the first movable portion can pivot with respect to the second movable portion so as to move the second end portion of the first movable portion away from the fourth end portion of the second movable portion, wherein the second movable portion defines a slot in the fourth end portion between the third and fourth side portions that is sized to receive the second end portion of the first movable portion such that the second end of the first movable portion and the fourth end of the second movable portion are axially aligned; and
a mechanism that pivotably moves the first movable portion and the second movable portion with respect to each other to expand a dimension of the expandable intervertebral fusion device, wherein the mechanism comprises:
a wedge extending from a fifth end to a sixth end and having an angled wedge surface extending along at least a portion of a distance between the fifth end and the sixth end, wherein the wedge is positioned between the first movable portion and the second movable portion with the angled wedge surface facing the first interior surface of the first movable portion, wherein the first interior surface of the first movable portion has an angled movable portion surface shaped to engage the angled wedge surface of the wedge, wherein a distance from the fifth end to the sixth end of the wedge is less than a distance from the first end to the second end of the first movable portion and is less than a distance from the third end to the fourth end of the second movable portion, wherein the wedge is configured to slide within a space defined between the first and second movable portions in a direction toward the second and fourth ends of the first and second movable portions from a first wedge position that allows the first and second movable portions to pivot to a device position that is substantially closed to a second wedge position whereby the angled wedge surface presses against the first interior surface of the first movable portion to hingedly open the first movable portion with respect to the second movable portion whereby the wedge remains axially confined within the space defined by the first and second movable portions in the first and second wedge positions; and
a rotation screw operably connected to the wedge and to the second movable portion, wherein rotation of the rotation screw moves the wedge in an axially translating direction with respect to the first movable portion and the second movable portion within the space defined between the first and second movable portions from the first wedge position to the second wedge position.

US Pat. No. 10,426,618

IMPLANTABLE DEVICE AND DELIVERY SYSTEM FOR RESHAPING A HEART VALVE ANNULUS

Millipede, Inc., Santa R...

1. An implant for reducing heart valve regurgitation comprising:a frame having upper crowns, lower crowns and struts between the upper and lower crowns, the frame having a tissue engaging configuration having a tissue engaging diameter and an annulus remodeling configuration where the frame has an annulus remodeling diameter that is less than the tissue engaging diameter;
a plurality of anchoring members coupled with the lower crowns of the frame for engaging cardiac tissue proximate the heart valve annulus; and
a plurality of collars coupled with the upper crowns of the frame, wherein when force is applied to the collars, the collars slide along the upper crowns and the struts to move the frame from the tissue engaging configuration towards the annulus remodeling configuration and wherein each collar includes at least one flex section configured to reduce friction between the collar and the upper crowns and the struts.

US Pat. No. 10,426,616

CARDIAC IMPLANT DELIVERY SYSTEM

Evalve, Inc., Santa Clar...

1. A delivery system configured for delivering an interventional device to a targeted treatment area within a body, the delivery system comprising:a steerable catheter having a proximal end and a distal end; and
an interventional device delivery system positioned within the steerable catheter and configured to be translatable within the steerable catheter so as to selectively deploy the interventional device beyond the distal end of the steerable catheter, the interventional device delivery system comprising:
a shaft; and
a sheath operatively coupled to the shaft, the sheath having a first portion, a second portion, and a space defined by the first portion and the second portion, the first portion of the sheath enclosing a first portion of the interventional device, the second portion of the sheath enclosing a second portion of the interventional device, and the first and second portions of the sheath being selectively moveable relative to one another and relative to the interventional device so as to:
selectively deploy the first portion of the interventional device from the sheath while maintaining the second portion of the interventional device within the sheath, or
alternatively, selectively deploy the second portion of the interventional device from the sheath while maintaining the first portion of the interventional device within the sheath, and
once one portion of the interventional device is deployed and positioned at the targeted treatment area, move the other portion of the sheath to selectively deploy the other portion of the interventional device,
wherein a portion of the sheath is translatable upon subjection to a hydraulic force, from a fluid ejected into the space enclosing the interventional device prior to the sheath separating to deploy the interventional device, to deploy one of the first portion or the second portion of the interventional device.

US Pat. No. 10,426,615

DELIVERY SYSTEM WITH PACING ELEMENT

Medtronic Vascular Galway...

1. A prosthetic heart valve delivery assembly comprising:a delivery system comprising a shaft and an implantable pacemaker removably attached at a distal end of the shaft, wherein the implantable pacemaker is configured to pace a heart; and
a prosthetic heart valve removably disposed over the shaft proximal of the implantable pacemaker such that implantable pacemaker is not attached to the prosthetic heart valve.

US Pat. No. 10,426,582

PERFORMED PROSTHESIS-BASE BLANK

Kulzer GmbH, Hanau (DE)

1. A denture base blank for producing a denture base for a denture with a subtractive CAM method, wherein the denture base blank comprises a wax or a plastic material selected from the group consisting of polymethyl methacrylates, polyether ketones, polyether ether ketones, polyamides, polycarbonates, and polyurethanes, the denture base blank is pre-formed, and a dental arch or a dental arch section is pre-formed as a material thickening of the denture base blank, wherein the material for the dental arch or dental arch section to be produced is contained in the material thickening and wherein the dental arch comprises the form of the denture base but not of prosthetic teeth to be inserted in the denture base.

US Pat. No. 10,426,571

INTELLIGENT HOLDING ARM FOR HEAD SURGERY, WITH TOUCH-SENSITIVE OPERATION

Medineering GmbH, Munich...

1. A method for controlling a mechatronic assistance system coupled to a holding arm to navigate said mechatronic assistance system during surgical treatment, the method comprising:coupling the mechatronic assistance system to a second interface at a distal end of the holding arm;
transmitting electrical energy and signals from a first interface at a proximal end of the holding arm to the second interface using a transmission unit arranged inside the holding arm;
detecting attitudes of one or more joints of the holding arm;
determining a pose of the holding arm based on the detected attitudes of the one or more joints; and
providing data representing the determined pose at the first interface.

US Pat. No. 10,426,569

STABILIZATION DEVICE AND METHOD FOR SURGICAL LOCALIZATION WIRE

1. A wire stabilization device for stabilizing a localization wire extending out of a patient's skin, the wire stabilization device comprising:a device body having a cover portion coupled to a base portion, a gripping mechanism, a device distal end, and a reception end;
an adhesive portion for securing the device body to the patient's skin;
wherein the base portion includes a base wall;
wherein the base wall includes a base slot extending into the base wall from the reception end towards the device distal end;
wherein the gripping mechanism comprises a set of ribs including a first cover rib, a second cover rib, and a first base rib;
wherein the gripping mechanism is configured to grip a portion of the localization wire extending between the base portion and the cover portion when the cover portion is in a closed position;
wherein the base slot is configured to receive the localization wire extending out of the patient's skin through the base slot, and the localization wire is bent between the location that the localization wire exits the patient's skin and a second location where the localization wire extends between the base portion and the cover portion, when the cover portion is in the closed position; and
wherein the first cover rib extends into a space between the first and second base ribs when the cover portion is in the closed position.

US Pat. No. 10,426,568

PROJECTION SYSTEM

PANASONIC INTELLECTUAL PR...

1. A projection system comprising:a light source that emits first light having a predetermined wavelength to a subject;
a camera that captures an image of a specific area in the subject, the specific area being specified by second light that is excited by the first light;
a projector that projects the image of the specific area and associated information associated with the image of the specific area by visible light;
a distance sensor that acquires a distance from the distance sensor to the subject by using third light having the predetermined wavelength;
a controller that adjusts a projection magnification in the projector based on the distance, acquired by the distance sensor, from the distance sensor to the subject; and
a mirror that causes an optical path of the camera with respect to the subject and an optical path of the projector with respect to the subject to coincide with each other, wherein:
the distance sensor emits the third light in a first period,
the light source does not emit the first light in the first period,
the controller determines, in the first period, whether the distance acquired by the distance sensor is in a predetermined allowable range,
in response to the determining that the distance is in the predetermined allowable range, the controller causes the distance sensor to stop emitting the third light in the first period and causes the light source to emit the first light in a second period, the second period being after the first period, and
in response to the determining that the distance is not in the predetermined allowable range, the controller causes the distance sensor to stop emitting the third light in the first period and causes the light source not to emit the first light in the second period.

US Pat. No. 10,426,560

ROBOTIC SYSTEM AND METHOD FOR REORIENTING A SURGICAL INSTRUMENT MOVING ALONG A TOOL PATH

Stryker Corporation, Kal...

1. A surgical manipulator comprising:a surgical instrument and an energy applicator extending from said surgical instrument, and wherein said surgical instrument and said energy applicator define a common axis; and
at least one controller configured to:
model said surgical instrument and said energy applicator as a virtual rigid body;
define a reference surface aperture in a reference surface;
determine forces and torques to be applied to the virtual rigid body to maintain the common axis within the reference surface aperture;
reposition said surgical instrument, based on the forces and torques, to maintain the common axis within the reference surface aperture; and
dynamically change a shape of the reference surface aperture.

US Pat. No. 10,426,545

METHOD AND APPARATUS FOR PERCUTANEOUS EPICARDIAL ABLATION OF CARDIAC GANGLIONATED PLEXI WITHOUT MYOCARDIAL INJURY

Mayo Foundation for Medic...

1. A method of ablating or modulating ganglia on an epicardial surface of a heart to treat cardiac disorders, the method comprising:sensing activity of the ganglia to identify a desired location on the epicardial surface;
placing an energy delivery assembly adjacent to the desired location, the energy delivery assembly comprising a plurality of electrodes;
coupling the energy delivery assembly to a source of non-thermal DC electrical energy;
selecting one or more characteristics of the non-thermal DC electrical energy; and
applying to the desired location, via the plurality of electrodes, the non-thermal DC electrical energy according to the selected one or more characteristics, wherein the selected one or more characteristics comprises applying the non-thermal DC electrical energy at a pulsation frequency of between 5 kHz and 10 kHz to ablate or modulate the ganglia without affecting pericardial and myocardial tissues of the heart.

US Pat. No. 10,426,538

INSTRUMENTS AND METHODS FOR ADJUSTING SEPARATION DISTANCE OF VERTEBRAL BODIES WITH A MINIMALLY INVASIVE SPINAL STABILIZATION PROCEDURE

Zimmer Spine, Inc., Edin...

1. An adjuster for adjusting a distance between vertebral bodies of a human spine, the adjuster comprising:a first handle member comprising:
a first proximal portion for grasping; and
a first distal portion including an extender engager defining a first longitudinal axis, the first extender engager configured to detachably couple to a first extender that can detachably couple to a bone fastener assembly;
a second handle member comprising:
a tube portion for receiving a shaft of a driver, the tube portion defining a second longitudinal axis; and
an engagement mechanism coupling the first handle member and the second handle member, the engagement mechanism permitting the first distal portion and the tube portion to translate laterally relative to each other;
wherein the engagement mechanism permits the first handle member to rotate relative to the second handle member.

US Pat. No. 10,426,535

SELF-HOLDING SCREW HEAD

Stryker European Holdings...

18. A bone fastener comprising:a threaded shaft at a leading end and a head connected to the shaft at a trailing end, the head having a threaded outer surface extending from a free end to an end connected to the shaft;
the head having a first diameter at the free end and a second diameter at the end connected to the shaft, each of the first diameter and the second diameter being measured at a root of a thread of the threaded outer surface, a crest adjacent to the second diameter being a maximum diameter of the bone fastener; and
the first diameter being less than the second diameter.

US Pat. No. 10,426,534

SEMI-CONSTRAINED BONE SCREW AND INSERTION INSTRUMENT

K2M, Inc., Leesburg, VA ...

1. A bone screw comprising:a tubular body defining a first longitudinal axis and having open proximal and distal ends defining a passageway therethrough;
a helical thread circumscribing an outer surface of the tubular body;
a head having a lumen extending therethrough, wherein a proximal opening of the lumen has a diameter greater than a diameter of a distal opening of the lumen, and a portion of an interior surface of the lumen tapers inwardly toward the distal opening of the lumen; and
a shaft slidably insertable through the lumen of the head and the passageway of the tubular body and into engagement therewith to rotatably fix the shaft relative to the tubular body, wherein a distal portion of the shaft is disposed distal of the distal end of the tubular body, wherein a proximal portion of the shaft is flared outwardly and has a maximum diameter greater than a maximum diameter of the distal portion of the shaft and greater than the diameter of the distal opening of the lumen of the head, and a portion of an exterior surface of the shaft tapers inwardly toward the distal portion of the shaft and is configured to at least partially contact the tapered interior surface of the lumen of the head when the shaft is assembled to the head, the shaft defining a second longitudinal axis, wherein the shaft couples the head to the tubular body such that a gap is defined between a distal surface of the head and the open proximal end of the tubular body, the head repositionable with respect to the first longitudinal axis of the tubular body and the second longitudinal axis of the shaft, wherein the shaft is configured to rotatably couple the tubular body to the head such that rotation of the head effectuates a corresponding rotation of the tubular body.

US Pat. No. 10,426,527

MINIMALLY INVASIVE SPINAL FIXATION SYSTEM AND RELATED METHODS

NuVasive, Inc., San Dieg...

1. A guide assembly for use with a spinal fixation system, the guide assembly comprising:an outer sleeve comprising an outer sleeve proximal end and an outer sleeve distal portion, the outer sleeve distal portion including a ridge configured to mate with a slot in an anchor element to secure the outer sleeve to the anchor element;
an inner arm assembly positioned within the outer sleeve, the inner arm assembly comprising first and second inner arm members positioned within the outer sleeve, wherein the first inner arm member comprises a first inner arm distal portion and the second inner arm member comprises a second inner arm distal portion, the first and second inner arm distal portions configured to engage the anchor element; and
an actuator moveable to cause translation of the first and second inner arm members from a first position to a second position with respect to the outer sleeve, whereby in the second position the first and second inner arm distal portions are in a locked engagement with the anchor element, wherein the actuator is a visual indicator configured to alert a user that the first and second inner arm distal portions are in a locked engagement, wherein the actuator comprises an actuator proximal end and an actuator distal end, wherein when the first and second inner arm members are in the second position the actuator proximal end is flush with the outer sleeve proximal end and the actuator distal end is distal of the outer sleeve proximal end, and when the first and second inner arm members are in the first position the actuator protrudes proximally from the outer sleeve proximal end.

US Pat. No. 10,426,526

SYSTEMS AND METHODS FOR INTRODUCING A BONE ANCHOR

NuVasive, Inc., San Dieg...

1. A guide assembly for introducing a bone anchor to an operative target site, the bone anchor including a housing having a pair of opposed arms defined by first and second opposed slots formed in the housing, comprising:an outer sleeve having a distal end, a proximal end, a central passage extending from the distal end to the proximal end, the outer sleeve being divided into a first outer arm and a second outer arm, the first outer arm and second outer arm being separated by a third slot open at the distal end and a fourth slot opposite the third slot and open at the distal end, wherein the first outer arm includes a first projection at the distal end extending into the central passage and the second outer arm includes a second projection at the distal end extending into the central passage, the first and second projections configured to engage first and second recesses formed in the housing arms, a first inner arm slidably coupled to the first outer arm such that the first inner arm translates longitudinally relative to the first outer arm, and a second inner arm slidably coupled to the second outer arm such that the second inner arm translates longitudinally relative to the second outer arm, the first inner arm and second inner arm being separated by a fifth slot and a sixth slot, the fifth slot being aligned with the third slot of the outer sleeve and the sixth slot being aligned with the fourth slot of the outer sleeve, the third and fifth slot together being aligned with the first slot of the housing and the fourth and sixth slot together being aligned with the second slot of the housing when the first and second projections are engaged in the first and second recesses of the housing, the first inner arm and second inner arm moveable between an open position and a closed position for temporarily fixing the housing to the guide assembly, the first inner arm having a first longitudinally extending engagement feature configured to slideably engage a complementary first longitudinally extending engagement feature on the housing when the first inner arm moves from the open position, the second inner arm having a second longitudinally extending engagement feature configured to slideably engage a complementary second longitudinally extending engagement feature on the housing when the second inner arm moves from the open position.

US Pat. No. 10,426,525

DEVICES AND METHODS FOR MONOAXIAL SCREW CONVERSION

1. A method for correcting spinal deformities, comprising:coupling a screw extension instrument to a receiving member of a polyaxial screw, the receiving member being coupled to a threaded shank that is polyaxially movable relative to the receiving member;
distally advancing relative to the receiving member of the polyaxial screw opposed arms of an inner component of the screw extension instrument that are disposed radially inward from opposed arms of the receiving member to exert a compressive force on a compression member disposed within the receiving member to convert the polyaxial screw into a monoaxial screw; and
retracting the inner component of the screw extension instrument relative to the receiving member to convert the monoaxial screw into a polyaxial screw after distally advancing the opposed arms of the inner component.

US Pat. No. 10,426,524

APPARATUS FOR SPINAL FIXATION AND METHODS OF USE

Spinal Elements, Inc., C...

1. A method, comprising:disposing a flexible band into contact with a first bone portion and into contact with a second bone portion, the flexible band having an aperture configured to receive a fastener that is configured to secure the flexible band to the first bone portion;
advancing a portion of the flexible band through an attachment connection of the flexible band until the first bone portion and the second bone portion are stabilized; and
advancing a portion of the fastener through the aperture and into the first bone portion until the flexible band is secured to the first bone portion, wherein the first bone portion is a spinous process of a first vertebra and the second bone portion is a spinous process of a second vertebra.

US Pat. No. 10,426,518

REVISABLE ORTHOPEDIC ANCHOR AND METHODS OF USE

DePuy Synthes Products, I...

1. A bone anchor member configured to be implanted in bone, comprising:a first probe component in the form of an elongate member having a proximal end and a distal end, a bone engaging edge having a plurality of barbs, an opposed edge, an external surface, and an opposed internal surface having a guide shoulder formed thereon, the guide shoulder extending in a diagonal curve across the internal surface of the first probe component, wherein the proximal end of the first probe component is connected to a first rod having an external surface and an opposed internal surface; and
a second probe component in the form of an elongate member having a proximal end and a distal end, a bone engaging edge having a plurality of barbs, a mating edge having a profile complementary to the guide shoulder and being configured to be seated along the guide shoulder, an external surface, and an opposed internal surface, wherein the proximal end of the second probe component is connected to a second rod, having an external surface and an opposed internal surface;
wherein the first and second probe components are configured to be assembled to form a bone anchor such that the barbed bone engaging edges of the first probe component and the second probe component face away from one another, the external surfaces of the first probe component and the second probe component face away from one another, the mating edge of the second probe component is seated along the guide shoulder of the first probe component, and distal ends of each probe component diverge away from one another; and
wherein the first and second rods are configured to be assembled to form a spinal fixation element such that the external surfaces of the first and second rods face away from one another.

US Pat. No. 10,426,511

DEVICE FOR DETACHING PARIETAL THROMBI FROM A BLOOD VESSEL

1. A device for detaching a parietal thrombus from a body vessel comprising:a catheter including at least one catheter section disposed longitudinally relative to the catheter;
a catheter wall including at least one wall opening passing completely through the catheter wall;
the catheter wall being disposed longitudinally relative to the least one catheter section and comprising a resiliently deformable material, the at least one wall opening including a separating gap wound helically with a constant pitch around the catheter wall at least in parts of the at least one catheter section including a cut passing completely through the catheter wall having two faces which include cutting edges that contact each other when the separating gap is closed, the catheter in a distal direction from the separating gap including a fixing device configured for releasably fixing the catheter to the body vessel;
means configured for severing at least part of the parietal thrombus from the body vessel including the cutting edges which are responsive to removal of torque acting on the catheter when the parietal thrombus is at least partially within the opening to sever the at least part of the parietal thrombus;
the catheter being configured so that torque acting on the catheter causes diameter of the catheter to expand from a smaller catheter outer diameter when the faces including the cutting edges contact each other to a larger catheter outer diameter which is constant along the catheter and causes the separating gap to change from being closed to being opened with the faces including the cutting edges being separated; and
the catheter, in an absence of an external constraint being applied thereto while the parietal thrombus is at least partially within the opening, is configured to spontaneously adopt the smaller catheter outer diameter due to resilient restoring forces of the resiliently deformable material causing the separating gap to close to activate the means configured for severing to cause the cutting edges to sever at least part of the parietal thrombus from the body when the parietal thrombus is at least partially within the opening; and wherein
the fixing device comprises a dilatable balloon mounted on the catheter and is either spaced distally from the separating gap or is positioned distally from the catheter, and the balloon is inflatable by a lumen which is disposed along the lumen.

US Pat. No. 10,426,505

HOLLOW STRANDED WIRE LINE FOR MANIPULATION

TOKUSEN KOGYO CO., LTD., ...

1. A hollow stranded wire line for manipulation, the hollow stranded wire line comprising a side wire or a side strand which is an outermost layer, the side wire or the side strand having a forming rate that is greater than 100% and not greater than 110%, whereinin a state where the hollow stranded wire line is disentangled, the side wire or the side strand having been formed has a flattened spiral shape, and wherein the side wire or the side strand has a spiral shape with a flatness having an aspect ratio obtained by a major axis being divided by a minor axis of not less than 1.01 and not greater than 1.10.

US Pat. No. 10,426,501

RETRIEVAL SNARE DEVICE AND METHOD

CRUX BIOMEDICAL, INC., M...

1. A method for capturing an object in a lumen defined by a lumen wall, the method comprising:advancing a sheath within the lumen, the sheath having a proximal end and a distal end, until the distal end of the sheath is proximal to the object;
deploying a plurality of loop elements of a snare out of the distal end of the sheath in a propeller-like configuration, wherein each of the plurality of the loop elements emanates from and returns to the distal end of the sheath, and wherein at least some of the plurality of loop elements comprise a first portion disposed out of the distal end of the sheath and extending distally of the distal end of the sheath and a second portion disposed out of the distal end of the sheath and extending proximally of the distal end of the sheath when the snare is fully deployed; and
capturing a portion of the object with at least one of the plurality of loop elements.

US Pat. No. 10,426,494

ANKLE ARTHROPLASTY SYSTEMS AND METHODS

LIMACORPORATE S.P.A., Ud...

1. A system for preparing a bone for joint arthroplasty, the system comprising:a burr comprising a rotatable cutting element having a shape, extending along a length of the rotatable cutting element, selected from the group consisting of a concave shape and a convex shape; and
a guide mechanism comprising:
a bone attachment interface securable to the bone;
a burr attachment interface securable to the burr; and
wherein the burr attachment interface is mechanically coupled to the bone attachment interface such that relative motion between the bone attachment interface and the burr attachment interface occurs along a non-linear pathway and is constrained to facilitate formation of a prepared surface on the bone with the burr, so that the prepared surface has at least one convex curvature.

US Pat. No. 10,426,482

DEVICES AND METHODS FOR EFFECTUATING PERCUTANEOUS GLENN AND FONTAN PROCEDURES

The United States of Amer...

1. A reinforced endograft shunt prosthesis, comprising:a distal flange configured to help seat the prosthesis when it is pulled proximally;
a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture in an open condition that is formed through a first vessel wall through which the distal segment passes;
a compliant middle segment extending proximally from the distal segment, the compliant middle segment being more compliant than the distal segment, and including a plurality of undulating strut rings attached to at least one of an inner tubular fabric and an outer tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being further configured to accommodate up to a 90 degree bend;
a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other, the proximal segment being sufficiently stiff to seat within and urge against a second vessel wall; and
an undulating proximal end including a tether that is threaded through the openings to cause the proximal end of the prosthesis to collapse radially inwardly when tension is applied to the tether.

US Pat. No. 10,426,478

SURGICAL STAPLING SYSTEMS

Ethicon LLC, Guaynabo, P...

1. A surgical stapling system comprising:an actuation system configured to selectively generate at least one control motion; and
a surgical end effector operably interfacing with said actuation system so as to receive said at least one control motion therefrom, said surgical end effector comprising:
a surgical staple cartridge comprising:
a cartridge body defining an elongate slot;
a plurality of staple pushers movably supported in said cartridge body for vertical travel therein, each said staple pusher operably supporting at least one staple thereon; and
a plurality of movable drivers operably supported in said cartridge body, wherein each said movable driver corresponds to at least one of said staple pushers and includes a camming surface thereon, and wherein said surgical stapling system further comprises an actuator sled supported for axial movement within said cartridge body in response to an application of said at least one control motion thereto, said actuator sled configured to move at least a portion of each of said movable drivers laterally away from said elongate slot into camming contact with said staple pusher corresponding thereto to thereby move said corresponding staple pusher vertically within said cartridge body.

US Pat. No. 10,426,464

METHODS AND APPARATUS FOR FIXING SHEET-LIKE MATERIALS TO A TARGET TISSUE

ROTATION MEDICAL, INC., ...

1. A system for attaching a sheet-like implant to tissue or bone comprising:a stapler including:
a fixation tool shaft comprising an elongated tubular member having a proximal end, a distal end, and a lumen therebetween,
wherein the distal end of the fixation tool shaft includes a first prong and a second prong which extend distally beyond the distal end of the lumen, the first prong and the second prong each being configured and adapted to form a first pilot hole and a second pilot hole respectively in a soft tissue and/or bone when pressed against the soft tissue and/or bone;
a staple push rod disposed within at least a portion of the lumen of the fixation tool shaft and slidable relative thereto, the staple push rod including a distal fork,
wherein the distal fork includes a first stake and a second stake extending distally therefrom,
wherein the first stake has a first proximal portion and a first distal portion, the first distal portion of the first stake being joined to the first proximal portion of the first stake by a first shoulder,
wherein the second stake has a second proximal portion and a second distal portion, the second distal portion of the second stake being joined to the second proximal portion of the second stake by a second shoulder;
a handle attached to the proximal end of the fixation tool shaft;
a trigger attached to the proximal end of the staple push rod and operably coupled to the handle such that the staple push rod will be advanced and/or retracted in an axial direction in response to movement of the trigger relative to the handle;
a staple carried by the staple push rod, the staple comprising:
a first arm having a proximal end and a distal end;
a second arm having a proximal end and a distal end;
a bridge element extending between the proximal end of the first arm and the proximal end of the second arm;
a first fluke attached to the distal end of the first arm, the first fluke having a first proximal end, a first proximally facing surface, and a first distal end; and
a second fluke attached to the distal end of the second arm, the second fluke having a second proximal end, a second proximally facing surface, and a second distal end,
wherein the first fluke defines a first passage way extending distally into the first fluke from the first proximally facing surface of the first fluke and the second fluke defines a second passage way extending distally into the second fluke from the second proximally facing surface of the second fluke,
wherein the first proximately facing surface of the first fluke is adapted to cooperatively mate with the first shoulder of the first stake to urge the first fluke into a first pilot hole adjacent to the first prong and the second proximately facing surface of the second fluke is adapted to cooperatively mate with the second shoulder of the second stake to urge the second fluke into a second pilot hole adjacent to the second prong when the trigger is moved relative to the handle.

US Pat. No. 10,426,451

EXPANDABLE MEDICAL ACCESS SHEATH

Gyrus ACMI, Inc., Southb...

1. A medical access sheath comprising:a first member, where the first member comprises a gap through a wall of the first member, where the first member comprises a first material; and
a second member connected to the first member, where the second member comprises a different second material,
where the first and second members form a tube, where the gap extends along a length of the tube measured along a longitudinal axis of the tube, where the wall of the first member forms a first wall portion of the tube along the length of the tube, and where the second member extends across the gap such that the second member forms a second wall portion of the tube at the gap along the length of the tube.

US Pat. No. 10,426,447

BIOPSY DEVICE

TERUMO KABUSHIKI KAISHA, ...

1. A biopsy device comprising:an elongated shaft extending from a proximal end to a distal end along a longitudinal axis;
a piercing spike configured to pierce a biological tissue, the piercing spike being disposed on the distal end of the elongated shaft;
a screw disposed on the elongated shaft, the screw configured to guide a specimen sampled from the biological tissue from the distal end of the elongated shaft toward the proximal end thereof;
a first screw cutter disposed on the screw configured to peel the specimen off the biological tissue, and disposed on a distal end of the screw;
a second screw cutter configured to separate the specimen peeled off the biological tissue, and disposed on a proximal end of the screw, wherein the first screw cutter is spaced apart from the second screw cutter along the longitudinal axis of the elongated shaft; and
a peripheral wall having a cutting edge extending from the first screw cutter to the second screw cutter, wherein the cutting edge is spaced radially outward from the elongated shaft and a portion of the screw;
wherein the first screw cutter is configured to peel the specimen off the biological tissue while the piercing spike is piercing the biological tissue.

US Pat. No. 10,426,440

SUBJECT INFORMATION OBTAINING APPARATUS, METHOD FOR OBTAINING SUBJECT INFORMATION, AND PROGRAM

CANON KABUSHIKI KAISHA, ...

1. A subject information obtaining apparatus that obtains information regarding a subject, the subject information obtaining apparatus comprising:a probe having a plurality of conversion elements;
the plurality of conversion elements being configured to transmit an elastic wave to the subject and receive a reflected elastic wave and convert the received elastic wave into a plurality of received signals;
a computing unit having a storage unit and a frequency-domain interferometry adaptive processing unit,
the storage unit being configured to store a plurality of predetermined reference signals each representing a received signal of a wave from a known interface of an object with mutually different incident angles, radii of curvature, or sizes; and
the frequency-domain interferometry adaptive processing unit being configured to execute a frequency-domain interferometry method and adaptive signal processing which adaptively applies weight on the plurality of received signals and two or more reference signals among the plurality of reference signals, to obtain a power intensity distribution for each of the two or more reference signals,
wherein the obtained two or more power intensity distributions are indicative of a spatial resolution of the information regarding the subject.

US Pat. No. 10,426,433

METHOD AND DEVICE FOR DETECTING ELASTICITY OF VISCOUS ELASTIC MEDIUM

WUXI HISKY MEDICAL TECHNO...

1. A method for detecting an elasticity of a viscoelastic medium, comprising:detecting a pressure applied to the viscoelastic medium by an ultrasonic transducer probe;
in response to the pressure satisfying a predetermined condition, triggering detection of the elasticity of the viscoelastic medium according to the following steps:
driving the ultrasonic transducer probe with a low-frequency vibration by a vibrator so as to produce an elastic wave in the viscoelastic medium;
producing an ultrasonic wave by the ultrasonic transducer probe, and transmitting the ultrasonic wave to the viscoelastic medium;
collecting an ultrasonic echo; and
calculating an elastic parameter of the viscoelastic medium according to the collected ultrasonic echo,
wherein the ultrasonic echo is collected when the elastic wave is propagated in the viscoelastic medium and the ultrasonic transducer probe stops or almost stops vibrating, wherein, a serial number Nselect of a collected ultrasonic echo satisfying:
Nselect?ceiling((T+?T)×Fhigh),
where ceiling(.) is a ceiling rounding function, Fhigh is a pulse repetition frequency of transmitting an ultrasonic signal and is within a range from 100 Hz to 100000 Hz, T is the duration of the vibration, the ultrasonic transducer probe stops or almost stops vibrating after the vibration starts for a period of T+?T,
when the elastic wave is propagated in the viscoelastic medium, the serial number Nselect of the collected ultrasonic echo satisfying:
Nselect?ceiling((D1/Vs1+T)×Fhigh);
where, D1 is a thickness of the viscoelastic medium, Vs1 is a lower limit of a propagation velocity of the elastic wave in the viscoelastic medium determined according to an estimated hardness range and an estimated density of the viscoelastic medium;
when ?T is less than D1/Vs1, by combining above two formulae, Nselect satisfying:
ceiling((T+?T)×Fhigh)?Nselect?ceiling((D1/V+T)×Fhigh); and
when ?T is not less than D1/Vs1, an elastic intermediate medium with a thickness of D2 and a first hardness is added between the ultrasonic transducer probe and the viscoelastic medium so that ?T ceiling((T+?T)×Fhigh)?Nselect?ceiling((D2/Vs2/D1/Vs1+T)×Fhigh).

US Pat. No. 10,426,425

CONTROL DEVICE, CONTROL SYSTEM, RADIATION IMAGING SYSTEM, CONTROL METHOD, AND STORAGE MEDIUM

CANON KABUSHIKI KAISHA, ...

1. An X-ray radiation imaging control device comprising:a display control unit configured to output, to a display unit, information indicating display content to be displayed on the display unit in order to cause the display unit to display imaging conditions for X-ray radiation imaging and an X-ray radiation image obtained by X-ray radiation imaging under at least one of the imaging conditions;
a determination unit configured to determine the presence or absence of abnormality concerning X-ray radiation imaging based on a dose index value derived from image data for the X-ray radiation image; and
a storage control unit configured to cause a storage unit to store the information indicating display content that is output to the display unit by the display control unit at a timing based on the abnormality in the case where the presence of abnormality is determined by the determination unit.

US Pat. No. 10,426,424

SYSTEM AND METHOD FOR GENERATING AND PERFORMING IMAGING PROTOCOL SIMULATIONS

GENERAL ELECTRIC COMPANY,...

1. A computer-implemented method for generating and simulating a computed tomography (CT) protocol, comprising:receiving, via a graphical user interface, at a processor user input comprising patient population size settings and scan technique settings for modeling the effects of the scan technique settings across a patient population as a function of patient size;
generating, via the processor, a patient population profile based on at least the patient population size settings and the scan technique settings, wherein the patient population profile comprises specific CT scan technique settings to be applied across different size ranges of the patient population as a function of patient size; and
displaying, on the graphical user interface, one or more visualization elements illustrating the effect of these specific CT scan technique settings on specific imaging metrics across the patient population.

US Pat. No. 10,426,422

RADIOGRAPHIC APPARATUS, RADIOGRAPHIC SYSTEM, RADIOGRAPHIC METHOD, AND STORAGE MEDIUM

Canon Kabushiki Kaisha, ...

1. A radiographic apparatus that obtains a radiographic image of a subject, the radiographic apparatus comprising:a detection unit including a first pixel configured to detect radiation and a second pixel configured to detect the radiation at a frame rate higher than a frame rate of the first pixel; and
a body movement detection unit configured to, while the subject is irradiated with the radiation, detect body movement of the subject by comparing a plurality of pieces of radiographic data detected by the second pixel with each other.

US Pat. No. 10,426,421

METHODS AND SYSTEMS FOR PROCESSING MOLECULAR IMAGING DATA BASED ON ANALYSIS OF A RESPIRATORY MOTION WAVEFORM

General Electric Company,...

1. A method, comprising:acquiring imaging data with a molecular imaging apparatus;
analyzing a respiratory motion waveform acquired during the acquiring imaging data; and
determining whether to apply gating to the acquired imaging data, where applying gating includes temporally dividing the acquired imaging data into groups or selecting only a portion of the acquired imaging data corresponding to a selected time period, based on the analyzed respiratory motion waveform, the determining including:
applying gating to the acquired imaging data in response to the analyzed respiratory motion waveform meeting a pre-determined threshold or metric and generating an image from the gated acquired imaging data and displaying the generated image to a user via a display screen; and
not applying gating to the acquired imaging data in response to the analyzed respiratory motion waveform not meeting the pre-determined threshold or metric and generating the image from the non-gated acquired imaging data and displaying the generated image to the user via the display screen;
wherein analyzing the respiratory motion waveform includes:
for each cycle of the respiratory motion waveform:
finding a peak amplitude of a cycle and dividing the cycle into a first segment before the peak amplitude and a second segment after the peak amplitude, where each cycle is defined between adjacent valleys of the respiratory motion waveform;
determining a first slope of the first segment and a second slope of the second segment; and
determining whether a difference between the first slope and the second slope is greater than a threshold.

US Pat. No. 10,426,418

PHANTOMS AND METHODS AND KITS USING THE SAME

Baylor College of Medicin...

1. A phantom comprising:a confined fluidic path defining a plurality of regions of monotonically decreasing, discrete cross-sectional dimensions with respect to an imaging plane;
one or more marker regions between adjacent regions of monotonically decreasing, discrete cross-sectional dimensions, the one or more marker regions having a cross-sectional dimension greater than the plurality of regions.

US Pat. No. 10,426,397

INFORMATIVE SYSTEM USING AND INSTRUMENTED AND CONNECTED HAIRBRUSH

WITHINGS, Issy les Mouli...

1. A system comprising a hairstyling tool and a remote entity configured to be connected together by a wireless connection, the hairstyling tool being a comb or a hairbrush,the hairstyling tool comprising:
a handle and a body, provided with teeth and/or bristles,
at least one movement sensor,
at least one three sensor configured to measure a torsional or bending stress exerted between the handle held by a user and the body engaged with the hair of said user,
at least one electric field sensor suitable for measuring an electric field generated by the electrostatic charges resulting from hairstyling movements,
an electronic control unit, configured to capture and format signals provided by the at least one force sensor, and by the at least one movement sensor, and the at least one electric field sensor,
at least one wireless communication coupler suitable for data transmission to the remote entity,
wherein the wireless communication coupler is configured to transmit to the remote entity data corresponding to information on the movements executed by the hairstyling tool through the hair and stresses entailed therefrom, as well as electric field sensed along said executed movements,
wherein the remote entity comprises at least one application configured to analyze the received data to formulate recommendations for hair care or products to be applied to the hair of the user, wherein the remote entity is configured to provide the recommendations to the user of the hairstyling tool via a display screen.

US Pat. No. 10,426,389

METHODS, SYSTEMS, AND DEVICES FOR ELECTRODE CAPACITANCE CALCULATION AND APPLICATION

MEDTRONIC MINIMED, INC., ...

1. A method for determining whether a used glucose sensor is being used by a user for measuring the level of glucose in the user's body, said sensor being a subcutaneous or implantable glucose sensor and including physical sensor electronics, a microcontroller, and a working electrode (WE) in an electrical circuit that provides an input current to the working electrode, the method comprising:(a) measuring, by said sensor electronics, a first current level for the working electrode current;
(b) after measuring said first current level, open circuiting, by said microcontroller, the working electrode by discontinuing said input current to the working electrode for a time period having a predefined duration, wherein said predefined duration is shorter than 30 seconds;
(c) during said time period, measuring, by said sensor electronics, a first WE voltage value and a second WE voltage value, said first value being measured at a first point in time after open circuiting the working electrode, said second value being measured at a second point in time after open circuiting the working electrode, and said first and second values being measured when the current level for the working electrode current is substantially zero;
(d) resuming said input current to the working electrode after said second point in time and calculating the working electrode's capacitance by the relation C=(I)/(dV/dT), wherein I is the first current level, dV is the difference between said first and second WE voltage values, and dT is the difference between said first and second points in time;
(e) periodically repeating steps (a)-(d) and monitoring the working electrode's capacitance over a predetermined time interval;
(f) determining, by said microcontroller, that the sensor is a used sensor when the change in the working electrode's capacitance over said predetermined time interval is less than a threshold value; and
(g) based on said determination that the sensor is a used sensor, prompting the user, by the microcontroller, to replace the used sensor with a new sensor.

US Pat. No. 10,426,386

NON-INVASIVE BLOOD GLUCOSE LEVEL MEASUREMENT METHOD AND NON-INVASIVE BLOOD GLUCOSE LEVEL MEASUREMENT DEVICE

SHINSHU UNIVERSITY, Mats...

1. A non-invasive blood glucose level measurement method comprising the steps of:measuring a first acceleration pulse wave from a test subject with an acceleration pulse wave measurement unit to obtain a measured first acceleration pulse wave and a first blood glucose level with an invasive measurement device to obtain a measured first blood glucose level;
constructing a calibration curve based on a correlation between the measured first acceleration pulse wave and the measured first blood glucose level;
storing the calibration curve in a data-analyzing unit;
measuring a second acceleration pulse wave with the acceleration pulse wave measurement unit to obtain a measured second acceleration pulse wave;
introducing the measured second acceleration pulse wave into the data-analyzing unit; and
calculating a second blood glucose level utilizing the stored calibration curve.

US Pat. No. 10,426,383

MUTING GLUCOSE SENSOR OXYGEN RESPONSE AND REDUCING ELECTRODE EDGE GROWTH WITH PULSED CURRENT PLATING

MEDTRONIC MINIMED, INC., ...

1. An analyte sensor apparatus comprising:a base substrate comprising a well;
a platinum composition disposed in the well, wherein:
the platinum composition is disposed in the well as a layer of electrodeposited platinum black comprising a central planar region having a first thickness and an edge region having a second thickness that surrounds the central planar region;
the first thickness is different from the second thickness;
the average thickness of the platinum black layer in the edge region is less than 2× the average thickness of the platinum black layer in the central planar region;
the central planar region and the edge region comprise platinum dendrites; and
the layer of electrodeposited platinum black forms an electroactive surface of a working electrode;
an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte; and
an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates the diffusion of analyte therethrough.

US Pat. No. 10,426,380

METHOD AND APPARATUS FOR MONITORING CARDIO-PULMONARY HEALTH

ResMed Sensor Technologie...

1. A cardio-pulmonary health monitoring apparatus comprising:a contactless motion sensor configured to generate one or more movement signals representing bodily movement of a patient during a monitoring session;
a processor; and
a memory storing program instructions configured to cause the processor to carry out a method of processing the one or more movement signals, the method comprising:
selecting one or more sections of the one or more movement signals, being sections during which the patient was asleep and not performing gross bodily movements,
extracting one or more sleep disordered breathing (SDB) features from said sections of the one or more movement signals, and
predicting whether a clinical event is likely to occur during a predetermined prediction horizon based on the one or more SDB features,
wherein the selecting comprises selecting one or more sections of good quality, and
wherein sections of good quality comprise sections in which a figure of merit for the movement signal over the section exceeds a noise threshold for the section, and
wherein the noise threshold for the section is the smaller of a maximum noise value for the motion sensor and a percentile of a distribution of root mean square (RMS) values of the movement signal over the section.

US Pat. No. 10,426,378

SYSTEMS AND METHODS FOR AUTOMATED BODY MASS INDEX CALCULATION TO DETERMINE VALUE

Massachusetts Mutual Life...

1. A computer-implemented method comprising:upon receiving, by a processor, height and weight data of a user,
requesting, by the processor, an electronic image of the user to be captured from an image capture device associated with a computing device operated by the user, the requested electronic image being inclusive of a standard sized object positioned in the electronic image according to at least one reference point for the electronic image;
receiving, by the processor, the electronic image of the user via a communications network from the computing device;
computing, by the processor, a baseline body mass index (BMI) of the user as a function of the height and weight data and the electronic image inclusive of the standard sized object positioned in the electronic image according to the at least one reference point for the electronic image; and
determining, by the processor, a baseline value as a function of the computed BMI for the user.

US Pat. No. 10,426,367

HAND-HELD VITAL SIGNS MONITOR

SOTERA WIRELESS, INC., S...

1. A method of determining a pre-ejection period (PEP) for a patient using a wearable vital signs sensor system, the method comprising:adhesively retaining a sensor component on the body of the patient at a position overlying the patient's sternum below the sternal notch, the sensor component comprising (i) an electrical sensor comprising an analog-to-digital converter and processing circuitry that is operably connected to primary, reference, and ground electrodes that measure electrical impulses from the patient indicative of cardiac activity, the electrical sensor generating a first time dependent waveform comprising electrocardiogram signals, and (ii) a piezoelectric sensor that measures low-frequency pressure waves from the patient's heart, the piezoelectric sensor generating a second time-dependent waveform comprising pressure wave frequency components from 40-500 Hz;
receiving the first time-dependent waveform and the second time-dependent waveform at a microprocessor configured to
process the first time-dependent waveform to identify a first signal indicative of onset of a cardiac cycle,
process frequency components between 40-500 Hz in the second time-dependent waveform to identify a second signal indicative of end of the PEP in the cardiac cycle,
determine a PEP for the cardiac cycle as the time separating the first signal and the second signal, and
cause the PEP for the cardiac cycle to be displayed on a display element operably connected to the microprocessor; and
causing the sensor component and the microprocessor to determine and display PEP for the patient in a continuous fashion for a plurality of cardiac cycles.

US Pat. No. 10,426,356

METHOD FOR ESTIMATING A QUANTITY OF A BLOOD COMPONENT IN A FLUID RECEIVER AND CORRESPONDING ERROR

Gauss Surgical, Inc., Me...

1. A method for communicating medical parameter information of a patient to a user, comprising:at a computing system, receiving data representative of a medical parameter;
determining a statistical component associated with the medical parameter;
updating an analysis of an aggregate amount of the medical parameter and an aggregate statistical component associated with the medical parameter, based upon the medical parameter and the statistical component; and
at a user interface device in communication with the computing system, providing information indicative of error derived from the analysis of the aggregate amount of the medical parameter and the aggregate statistical component to the user.

US Pat. No. 10,426,350

METHODS AND SYSTEMS FOR TRACKING AND GUIDING SENSORS AND INSTRUMENTS

ZITEO, INC., Pleasant Hi...

1. A spatial registration apparatus comprising:a gamma ray detector;
a camera rigidly connected with the gamma ray detector;
a fiducial marker affixed to an object of interest, the object of interest being different from the gamma ray detector and different from the camera; and
at least one processor operatively coupled with a memory, the memory having instructions for execution by the at least one processor, wherein the memory stores a relative location and orientation between the gamma ray detector and the rigidly connected camera, wherein the instructions, when executed by the at least one processor, cause the at least one processor to determine a pose of the camera with respect to the fiducial marker using an image of the fiducial marker captured by the camera and then transform the pose, using the stored relative location and orientation between the gamma ray detector and rigidly attached camera, to determine a first spatial position and orientation of the gamma ray detector with respect to the fiducial marker, the at least one processor associating scanning data from the gamma ray detector with the first spatial position and orientation of the gamma ray detector to create a first spatially registered scan, the scanning data from the gamma ray detector being time synchronized with the first spatial position and orientation of the gamma ray detector.

US Pat. No. 10,426,344

MEDICAL SERVICE SUPPORT DEVICE, MEDICAL SERVICE SUPPORT SYSTEM AND MEDICAL SERVICE SUPPORT METHOD

Nihon Kohden Corporation,...

1. A medical service support device comprising:a measurement unit attached to a patient and including at least one sensor that is configured to measure biological information of the patient;
an analysis unit configured to analyze the biological information;
a detection unit configured to detect a motion of the patient; and
an attention calling unit configured to transmit attention calling information and patient identification information for specifying the patient toward the external portion of the device when it is determined that the patient is in a REM sleep state based on an analysis result by the analysis unit as well as determined that the patient has moved to a given state based on a detection result by the detection unit, wherein the given state indicates the motion exceeds a change amount, the change amount based on a dimension of the patient's bed and a dimension of the patient.

US Pat. No. 10,426,337

FLOW IMAGING IN AN OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEM

SANTEC CORPORATION, Koma...

1. An optical coherence tomography (OCT) system comprising:a light source configured to generate a probe beam having an adjustable swept rate and swept range;
an interferometer and beam scanning optics configured to scan the probe beam onto a sample;
a detector configured to measure an OCT interference signal returning from the sample;
a processor configured to generate an OCT image of a flow of the sample, wherein the processor is configured to:
scan a B scan of a sample N times at a first slice of the sample, wherein:
N is greater than or equal to 2,
the B scan comprises a plurality of A scans,
a pixel of the first slice has an M number of A scans within the pixel,
each of the A scans has a spectrum range less than a full spectrum range of the light source, and
a number of pixels per B scan is an approximate B scan length divided by a lateral resolution size of the pixel; and
determine a flow image of the sample using an optical coherence tomography (OCT) signal reflected back from the sample.

US Pat. No. 10,426,335

OPHTHALMIC IMAGE DISPLAY DEVICE AND OPHTHALMIC IMAGING DEVICE

KABUSHIKI KAISHA TOPCON, ...

1. An ophthalmic image display device comprising a display controller configured to display information on a display means, and an operation unit,wherein the display controller
displays a B mode image, a blood vessel enhanced image representing a same cross section as the B mode image, the blood vessel enhanced image formed based on a plurality of optical coherence tomography data acquired through iteratively scanning substantially a same area of a subject's eye, and one or more front images individually formed based on a three dimensional data set acquired by performing optical coherence tomography on the subject's eye in a predetermined layout,
displays a cross section position indicator that indicates a position of a cross section of the B mode image over at least one of the one or more front images, and
synchronously performs changing of a display position of the cross section position indicator and updating of a display of each of the B mode image and the blood vessel enhanced image in accordance with an operation for moving the cross section position indicator performed using the operation unit.

US Pat. No. 10,426,332

SYSTEM AND DEVICE FOR PRELIMINARY DIAGNOSIS OF OCULAR DISEASES

Eyecare S.A., Santiago (...

1. A method for the preliminary diagnosis of ocular diseases, the method comprising:capturing a plurality of images of the eyes of an individual with a camera using a flash, wherein the plurality of images of the eyes have a same orientation;
estimating an amount of light contained in each image of the plurality of images of the eyes;
discarding one or more respective images of the eyes that contain no flash light, based on the estimated amount of light contained in each image of the plurality of images of the eyes, thereby obtaining a plurality of remaining images of the eyes;
at least one of cropping, aligning, and filtering respective images of the eyes of the plurality of remaining images of the eyes to provide a final corrected image of the eyes;
displaying said final corrected image of the eyes on a display screen;
calculating, from the final corrected image of the eyes, percentages of respective colors in a pupillary reflex of each eye, wherein the respective colors include red, white, orange and yellow colors; and
determining a first diagnosis of a first ocular disease for the individual based at least in part on the percentages of respective colors in the pupillary reflex of each eye as calculated from the final corrected image of the eyes.

US Pat. No. 10,426,331

AUTOMATED QUANTIFICATION OF NONPERFUSION IN THE RETINA USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

1. A computer-based method of measuring nonperfusion in the retina, the method comprising:obtaining an optical coherence tomography (OCT) angiogram;
thresholding the OCT angiogram, thereby generating a binary vessel mask, wherein thresholding the OCT angiogram comprises:
obtaining a structural OCT;
generating an en face reflectance image from the structural OCT;
filtering the en face reflectance image, thereby generating a reflectance-adjusted threshold image including respective reflectance-adjusted thresholds; and
thresholding the OCT angiogram using the respective reflectance-adjusted thresholds, thereby generating the binary vessel mask;
generating a vessel distance map from the binary vessel mask; and
generating a nonperfusion map from the vessel distance map.

US Pat. No. 10,426,330

SELF-ILLUMINATED HANDHELD LENS FOR RETINAL EXAMINATION AND PHOTOGRAPHY AND RELATED METHOD THEREOF

University of Virginia Pa...

1. A self-illuminated handheld lens for wide angle retinal viewing of a subject eye, comprising:an aspherical viewing lens having a symmetric viewing axis and defining a central aperture;
plurality of LEDs positioned around said viewing axis and configured to emit light to illuminate said subject eye;
an electronic controller powering said plurality of LEDs and controlling each individual LED or a series of LEDs independently; and
a light baffle configured to block stray light of said plurality of LEDs from getting into said central aperture.

US Pat. No. 10,426,329

MULTIPURPOSE SELF-ILLUMINATING DENTAL MIRROR

1. A multipurpose self-illuminating dental mirror, comprising:a first assembly that includes a head having a mirrored forward surface and a rear transparent surface that includes one or more rear-facing light sources, a shank connected at first end to a side of the head and extending longitudinally at an angle from the plane of the head having one or more forward-facing light sources extending from the shank at the connection of the shank with the head, and wiring from the one or more rear-facing light sources and one or more forward-facing light sources that extends through the shank to a first electrical connector at a second end of the shank;
a second assembly that includes a handle having a housing for one or more batteries, wiring that electrically connects the one or more batteries to a second electrical connector at a first end of the handle and a third electrical connector at a second end of the handle, and a switch that connects or disconnects the one or more batteries and the second electrical connector, wherein in the first assembly is physically connected to the second assembly through a first detachable connection so that the second end of the shank is physically connected to the first end of the handle and the first electrical connector is electrically connected to the second electrical connector; and
a third assembly that includes a laser pointer that directs laser light from a first end of the laser pointer and a switch that connects or disconnects the laser pointer to a fourth electrical connector located at a second end of the laser pointer, wherein the third assembly is physically connected to the second assembly through a second detachable connection so that the second end of the laser pointer is physically connected to the second end of the handle and the fourth electrical connector is electrically connected to the third electrical connector.

US Pat. No. 10,426,327

FLUID FILTRATION, CLEANING, AND DEFOGGING DEVICE

Buffalo Filter LLC, Lanc...

1. An apparatus for aiding medical procedures, the apparatus comprising:(a) a housing defining a first opening, a second opening, and an interior;
(b) a first cleaning element maintained within the interior proximate to the first opening, the first cleaning element comprising at least one cleaning agent operable to remove extraneous debris from an object;
(c) a second cleaning element maintained within the interior proximate to the second opening, the second cleaning element comprising at least one cleaning material and at least one white reference material, the at least one cleaning material operable to remove debris from an object; and
(d) a conduit defining a passage from a first end of the housing to a second end of the housing, the conduit comprising at least one filter and at least one liquid trap, the conduit operable to allow a flow from the first end of the housing to the second end of the housing and to remove debris from the flow by at least one of the filter and the liquid trap.

US Pat. No. 10,426,326

FIBER OPTIC CORRECTION OF ASTIGMATISM

Canon U.S.A, Inc., Melvi...

1. An optical probe comprising:a sheath having a hollow interior for housing a light source; and
a waveguide for guiding a light created by the light source through the sheath,
wherein the waveguide has asymmetric optical power for reducing astigmatism of the light traveling through the sheath.

US Pat. No. 10,426,320

SINGLE USE MEDICAL DEVICES

Xiaolong Ouyang, Bellevu...

22. A method of using an endoscope made of a single-use portion configured for insertion into a patient and a reusable portion to which the single-use portion is detachably attached to form said endoscope, said method comprising:introducing said single-use portion into a patient and imaging a field of view in the patient during a medical procedure using electronic components in said single-use portion; and
causing a self-sacrificing module (SSM) in said single-use portion to automatically respond to an attempt to sterilize the single use portion after use thereof in said medical procedure by automatically preventing operation of said electronic components to thereby render the single-use portion unusable for a patient procedure;
wherein said SSM comprises a clock line configured to supply clock pulses to said electronic components and a switch responsive to said attempt to sterilize to disable said clock line and thereby deprive said electronic components of said clock pulses and make the electronic components non-functional.

US Pat. No. 10,426,313

DISHWASHER

LG Electronics Inc., Seo...

1. A dishwasher comprising:a tub configured to accommodate an object;
a pair of main arms that extend in a first extension direction and that are configured to (i) rotate about a first axis inside the tub, (ii) receive incoming water from a water source, (iii) guide first water of the incoming water through a first flow path and second water of the incoming water through a second flow path, and (iv) spray the first water to the object;
a pair of auxiliary arms that extend in a second extension direction to define a predetermined angle with respect to the main arms, that are coupled to the main arms, and that are configured to (i) rotate about a second axis inside the tub and (ii) spray the second water to the object; and
a pair of auxiliary arm connectors that are disposed at the main arms, that are configured to couple to the auxiliary arms, and that are rotatable with the auxiliary arms, the auxiliary arm connectors including:
an auxiliary flow path guide that is configured to (i) change a water flow direction of the second water from the main arms to the auxiliary arms and (ii) control water pressure of the second water, and
a flow path formation rib that is disposed at an inner surface of the auxiliary flow path guide and that is configured to (i) divide the incoming water into the first water and the second water and (ii) control the water pressure of the second water based on a volume of the second water.

US Pat. No. 10,426,312

INTEGRATED SCRAPER-SPONGE

Sani Products, Inc., Eug...

1. An integrated scraper-sponge comprising:a first sponge layer of absorbent material and a second sponge or scrub layer of absorbent material or abrasive material, the first and second layers mated to one another at an interface and being configured and dimensioned to define a sponge body having a first surface being a surface of the first sponge layer and a second surface being a surface of the second sponge or scrub layer, and a continuous side surface around the perimeter;
and
a scraper layer fixed between the first and second layers at the interface thereof, wherein the scraper layer includes
a scraper edge portion protruding outwardly from a section of the continuous side surface of the sponge body,
a support structure body having an area configured and dimensioned to fit between at least a major portion the interface,
a plurality of apertures within the area of the support structure body perimeter defining the interface of the first and second layers, and
an interface portion between the scraper edge portion and the support structure body that is within the sponge body.

US Pat. No. 10,426,307

CLEANER

LG Electronics Inc., Seo...

1. A cleaner comprising:a suction unit configured to guide air into the cleaner;
a dust separation unit comprising:
a first cyclone unit configured to separate dust from air that is suctioned into the cleaner through the suction unit; and
a second cyclone unit configured to separate dust from air that is discharged from the first cyclone unit;
a suction motor configured to drive a rotation of a rotary impeller via an impeller shaft to generate a suction force that suctions air into the cleaner through the suction unit;
a motor housing that is configured to house the suction motor;
a cleaner body that is configured to accommodate the motor housing, and that has a first opening that provides access to an interior of the cleaner;
a pre-filter that is configured to be inserted into the cleaner body through the first opening, and that is configured to filter air that is discharged from the second cyclone unit and before the air enters the motor housing; and
an exhaust filter unit that is configured to be coupled to the cleaner body to close the first opening of the cleaner body, and that is configured to filter air that is discharged from the suction motor, wherein in a state of being coupled to the cleaner body, the exhaust filter unit is configured to apply pressure to the pre-filter and maintain the pre-filter inserted in the cleaner body.

US Pat. No. 10,426,298

CAPPED RIM SYSTEM FOR A BATHTUB

KOHLER CO., Kohler, WI (...

1. A bathtub comprising:a bathing well comprising an inner surface, a supporting structure, and a rim, the rim having a rim inner flange extending from the inner surface to an inner well wall and a rim outer flange extending from the inner well wall to the supporting structure, the rim defining an inner well between the rim inner flange, the inner well wall, and the rim outer flange;
a rim cap having a rim cap inner flange disposed over the rim inner flange and a rim cap outer flange disposed over the rim outer flange; and
an electronic component disposed in at least one of the inner well or the rim cap.

US Pat. No. 10,426,296

COFFEE GRINDER

VAN DEUCE PTY LTD, New S...

1. An apparatus for discharging ground coffee beans comprising:a first container for the retention of coffee beans therein, the first container having a first aperture arranged to receive coffee beans therethrough, and an opposing second aperture arranged to dispense coffee beans therethrough;
a conical burr grinder arranged to grind the coffee beans dispensed through the second aperture of the first container;
a motor arranged to drive the conical burr grinder, the motor being disposed within the first container and above the conical burr grinder, wherein the positioning of the motor within the first container is such that there is an evenly distributed weight of the coffee beans retained within the first container on the conical burr grinder;
a motor support portion disposed within and concentric with the first container, the motor support portion being arranged to support the motor directly above the conical burr grinder and to separate the motor from the coffee beans retained within the first container, wherein the motor is centrally positioned within the motor support, and wherein the motor, the motor support and the first container are coaxially aligned; and
the conical burr grinder configured to vertically discharge the ground coffee beans, wherein the motor, the motor support and the first container are axially spaced from the conical burr grinder; and
the apparatus further comprising a second container supported vertically below the conical burr grinder to receive the vertically discharged ground coffee beans from the conical burr grinder; and
the apparatus further comprising a motor shaft partially contained within the motor support and extending through a lower opening of the motor support into the first container.

US Pat. No. 10,426,294

GRILL WITH STOVE ATTACHMENT DEVICE

1. A cooking device, comprising:A. a grill, comprising a grill underside,
B. a stove comprising cookware support extensions,
C. a plurality of legs attached to said grill, and
D. a connection mechanism rigidly attached to said grill underside, wherein said connection mechanism positions said cookware support extensions tightly against said underside of said grill for optimum heat transfer.

US Pat. No. 10,426,292

TEMPERATURE REGULATION DEVICE

THE VOLLRATH COMPANY, L.L...

1. A temperature regulation device comprising: a housing for positioning at least partially in a well and including a top surface, a bottom surface, a first side, and a second side, wherein the first side includes a first support surface that supports the housing when the housing is positioned in a first position relative to the well, and wherein the second side includes a second support surface that supports the housing when the housing is positioned in a second position relative to the well, the first side positioned opposite from the second side; wherein the first support surface is spaced apart from the top surface by a first dimension, and the second support surface is spaced apart from the top surface by a second dimension, wherein the first dimension is larger than the second dimension; wherein the first side comprises a first recess extending from the bottom surface toward the top surface and terminating at the first support surface, and the second side comprises a second recess extending from the bottom surface toward the top surface and terminating at the second support surface.

US Pat. No. 10,426,285

BELT HANGER, AND BELT HANGING STRUCTURE USING THE SAME

Yonosuke Miki, Hyogo (JP...

1. A belt hanger for supporting at least a locking pin of a pin-type belt that includes a single-pin buckle, the belt hanger comprising a support member capable of suspending and holding the pin-type belt by supporting the locking pin with the support member,wherein the support member comprises a first support portion capable of simultaneously supporting a plurality of portions of the locking pin that are separated in a length direction of the locking pin,
wherein the first support portion of the support member includes a flexible plate-shaped member having a length, a width, a first side, and an opposite second side, the plate-shaped member having at least two through holes arranged side-by-side in the direction of the length of the plate-shaped member, and
the first support portion being configured to support the plurality of portions of the locking pin in the length direction of the locking pin, when the locking pin is in a state of being inserted into a lower through hole out of the at least two through holes from the first side to the second side of the plate-shaped member, and then inserted into an upper through hole out of the at least two through holes from the second side to the first side of the plate-shaped member such that the locking pin is inserted through each of the at least two through holes.

US Pat. No. 10,426,272

BUOYANT POOL LOUNGE CHAIR FRAME AND BUOYANT POOL LOUNGE CHAIR USING THE SAME

TRC Recreation, LP, Wich...

1. A buoyant pool lounge chair for supporting a person while the buoyant pool chair is floating in water, comprising:frame members collectively forming an open chair frame, the frame members including a seat frame having a front end and a rear end, the seat frame having a top side and a bottom side;
the frame members including a back frame pivotally coupled to the rear end of the seat frame, the frame members including a leg frame pivotally coupled to the front end of the seat frame;
buoyant cushions attached to the frame members, the buoyant cushions forming a chair seat, a backrest, and a leg rest;
a pair of rear pivotal coupling and clutch assemblies coupled to the seat frame and to the back frame, each of the pair of rear pivotal coupling and clutch assemblies including a manually operable actuator that is releasable to permit pivotal movement of the back frame relative to the seat frame, and engageable to fix the angle of recline of the back frame relative to the seat frame; and
a pair of front pivotal coupling and clutch assemblies coupled to the leg frame and to the back frame, each of the pair of front pivotal coupling and clutch assemblies including a manually operable actuator that is releasable to permit pivotal movement of the leg frame relative to the seat frame, and engageable to fix the angle of extension of the leg frame relative to the seat frame.

US Pat. No. 10,426,269

CHAIR WITH APPENDAGE ACCOMMODATIONS

Buzz Seating, Inc., Cinc...

1. A chair, comprising:a portion of a back member that tapers from top to bottom at an angle of approximately 22 degrees, wherein the back member is attached under a bottom surface of a seat at a back of the seat, wherein a gap exists between a back surface of the seat and a front surface of the back member;
the seat that tapers from a front to the back at an angle of approximately 35 degrees;
two retractable arm brackets attached on opposing sides of the seat, each retractable arm bracket including a push button to retract the arms down in the rearward direction to provide a larger seat clearance from an original seat clearance when both of the two retractable arms are in an original upright position;
a seat height adjustment lever situated under the seat on a first side including a tilt tension adjustment on a first lever;
a front-to-back integrated seat slider adjustment lever situated under the seat on a second side;
a four position anti-kick lock lever situated under the seat on the second side and attached to the front-to-back integrated seat slider adjustment lever;
a center portion attached under the seat that includes the first lever, the seat slider adjustment lever, and the four position anti-kick lock lever; and
a base including six legs, each leg including a caster.

US Pat. No. 10,426,263

KITCHEN UTENSIL SUSPENSION ASSEMBLY

1. A kitchen utensil suspension assembly being configured to suspend pots and pans in a kitchen, said assembly comprising:a pair of brackets, each of said brackets being coupled to a vertical support surface, said brackets being spaced apart from each other;
a plurality of supports, each of said supports being pivotally coupled to a respective one of said brackets, each of said supports being positionable in a deployed position having each of said supports being oriented at an angle with respect to the vertical support surface, each of said supports being positionable in a stored position having each of said supports extending upwardly along the vertical support surface; and
a plurality of poles, each of said poles extending through each of said first and second supports wherein each of said poles is configured to have a kitchen utensil suspended thereon for storage;
a panel being coupled between each of said brackets, said panel having a forwardly facing surface;
a motion sensor being coupled to said forwardly facing surface of said panel wherein said motion sensor is configured to detect motion within a trigger distance of said panel; and
a light emitter, said light emitter being coupled to said forwardly facing surface of said panel wherein said light emitter is configured to emit light outwardly therefrom, said light emitter being electrically coupled to said motion sensor, said light emitter being turned on when said motion sensor senses motion.

US Pat. No. 10,426,260

ADJUSTABLE HEIGHT DESK HAVING A DEPLOYABLE FLOOR MAT

1. A desk, comprising:a tabletop;
at least one base member supporting the tabletop, the at least one base member being slidably movable between a sitting position and a standing position;
a connection bar rotatably coupled to the at least one base member;
a footrest coupled to and displaced from the connection bar, the footrest rotatable with the connection bar between a stowed position toward a back of the desk and a deployed position toward a front of the desk;
at least one mechanism disposed on the at least one base member and operatively coupled to the footrest, the at least one mechanism rotating the footrest between the stowed and deployed positions while moving the base member between the sitting position and the standing position; and
a floor mat coupled to the connection bar, wherein rotation of the footrest and the connection bar causes movement of the floor mat between a stowed mat position and a deployed mat position.

US Pat. No. 10,426,258

SLIDING MECHANISM

Safran Seats USA LLC, Ga...

1. A tray table assembly comprising:a lateral member;
at least one pivot arm attached to the lateral member;
a sliding mechanism attached to the lateral member; and
a tray base attached to the sliding mechanism, wherein:
the sliding mechanism comprises at least one outboard link, at least one pivot link, and at least one rear link;
the tray table assembly comprises a retracted configuration and an extended configuration; and
a first end of the at least one outboard link is attached to the lateral member and a second end of the at least one outboard link is connected to the at least one pivot link by a first pin joint and the at least one rear link is connected to the at least one pivot link by a second pin joint.

US Pat. No. 10,426,257

AUTOMATIC HANDLE ASSEMBLY SYSTEM FOR PAINT BRUSH

Jiangsu Normal University...

1. An automatic handle assembly system for a paint brush, comprising a feeding device, a conveying device, and a handle pushing device, the feeding device being disposed on a right side of the conveying device, and the handle pushing device being disposed on a rear side of the conveying device;wherein the feeding device is used for transporting a glue-filled paint brush head to an entrance of the conveying device;
the conveying device is used for realizing transportation, pressing and precise positioning of the paint brush head; and
the handle pushing device is used for pushing a paint brush handle to precisely insert into the paint brush head, and completing the assembly of the paint brush handle;
the feeding device includes a base, a mounting plate, a guiding mechanism, a transversely-moving cylinder, an elevation cylinder, an electromagnetic chuck, and a threaded connecting piece,
wherein the mounting plate is horizontally fixed on the base, the transversely-moving cylinder is disposed at the mounting plate; the guiding mechanism includes a first gantry, a second gantry, a guiding rod, a linear bearing, and a connecting piece, wherein the first gantry and the second gantry are fixed on the mounting plate, and the guiding rod is horizontally fixed on the first gantry and the second gantry; one end of the guiding rod passes through the first gantry to extend onto the second gantry, and the other end of the guiding rod extends above the entrance of the conveying device, the linear bearing is sleeved on the guiding rod, and the connecting piece and the linear bearing are integrally connected as one piece; the elevation cylinder is fixed at a bottom of the connecting piece, and a piston rod of the transversely-moving cylinder is connected to the connecting piece; and the electromagnetic chuck is disposed on a piston rod of the elevation cylinder through the threaded connecting piece.

US Pat. No. 10,426,256

BRISTLE INSERT, BRUSH WITH SUCH BRISTLE INSERT, AND METHOD FOR MANUFACTURING SUCH BRISTLE INSERT

Bart Gerard Boucherie, (...

1. A brush comprising:a brush body comprising a handle;
a bristle insert attached to the handle and including at least one bristle pack with a plurality of plastic bristles having ends that are fused to each other to form a self-supporting holding element, wherein the at least one bristle pack includes different bristles that differ from each other in at least one of bristle thickness, bristle material, or bristle color; and
wherein the self-supporting holding element is a plate, and wherein the bristle pack includes a cavity adjacent to the self-supporting holding element, and wherein the cavity is comparatively sharply delimited in direct vicinity of the self-supporting holding element, and wherein more bristles extend into the cavity at an increasing distance away from the self-supporting holding element than at a location near the self-supporting holding element, and wherein the self-supporting holding element is adhered or welded to the brush body.

US Pat. No. 10,426,255

ORAL CARE INSTRUMENT

Colgate-Palmolive Company...

1. A toothbrush comprising:a base component comprising
a gripping region, and
an oral engaging region defining a longitudinal axis along a length of the oral engaging region and a transverse axis along a width of the oral engaging region;
wherein the oral engaging region has a front side, the oral engaging region having bilateral symmetry with respect to a plane extending along the longitudinal axis perpendicular to the front side of the oral engaging region and comprises a distal region having an outer surface with a convex contour, the distal region gradually tapering to a middle region having an outer surface with a concave contour, the middle region gradually widening to a proximal region having an outer surface with a convex contour;
wherein a plurality of cleaning elements extend from the front side of the oral engaging region, wherein a portion of the plurality of cleaning elements are longest in length as measured from the front side to the oral engaging region at least near a distal end of the oral engaging region; and
wherein the plurality of cleaning elements are formed in a trim profile that approximately matches a shape of a lateral side of the oral engaging region such that a length of the plurality of cleaning elements in the distal and proximal regions is greater than a length of the plurality of cleaning elements in the middle region, the plurality of cleaning elements gradually decreasing in length from the distal end and a proximal end of the oral engaging region towards the middle region.

US Pat. No. 10,426,252

ORAL CARE SYSTEM AND METHOD

Colgate-Palmolive Company...

1. A dispenser comprising:a housing defining a longitudinal axis;
a pressurized product tube disposed in the housing and including a reservoir containing a material;
an outlet in fluid communication with the reservoir;
a valve fluidly coupled to the outlet, the valve being movable between an open dispensing position and a closed non-dispensing position; and
a compression device disposed inside the housing of the dispenser, the compression device configured to apply pressure to the product tube for dispensing the material, wherein the compression device includes a pair of opposing pressure plates resiliently biased into engagement with opposing sides of the product tube, the plates operable to squeeze the material from the reservoir when the valve is in the open dispensing position;
wherein the valve is configured to dispense the material from the reservoir under pressure when in the dispensing position;
wherein the valve includes an orifice movable into and out of a flow path defined through the outlet; and
wherein the pressure plates are resiliently coupled together by a pair of elastomeric members each anchored to mating opposing longitudinal edges of the pressure plates along opposing lateral sides of the compression device.

US Pat. No. 10,426,251

ORAL CARE SYSTEM AND ORAL CARE MATERIAL DISPENSER

Colgate-Palmolive Company...

1. An oral care system comprising:a toothbrush;
a dispenser detachably mounted to the toothbrush, the dispenser comprising:
a housing forming an internal cavity extending along a longitudinal axis between a proximal end and a distal end;
an elevator slideably disposed within the internal cavity that separates the internal cavity into a reservoir for containing an oral care material and a chamber, the elevator including an annular sealing portion having a proximal edge, distal edge, and sidewall therebetween that forms a fluid seal with the housing, a plug portion protruding axially from the sealing portion towards the distal end of the housing, and a mounting stem portion protruding axially beyond the proximal edge of the sealing portion towards the proximal end of the housing;
a dispensing orifice at the distal end of the housing for dispensing the material from the reservoir;
an actuator rotatably coupled to the housing;
a drive screw positioned in the chamber, the drive screw non-rotatably coupled to the actuator such that rotating the actuator rotates the drive screw, wherein the drive screw does not penetrate through the elevator into the reservoir; and
a tubular extension member having a distal end detachably coupled to the elevator via a component interface and a proximal end threadably coupled to the drive screw, the extension member being non-rotatable with respect to the housing;
wherein rotation of the actuator in a first direction causes the extension member and elevator to axially advance along the drive screw towards the dispensing orifice for dispensing the material due to relative rotation between the drive screw and the extension member.

US Pat. No. 10,426,249

ORAL CARE IMPLEMENT

Colgate-Palmolive Company...

1. An oral care implement comprising:a handle;
a head coupled to the handle and having a front surface;
a first tuft of cleaning elements extending from the front surface of the head along an axis and comprising a first plurality of cleaning elements formed of an elastomeric material;
a second tuft of cleaning elements extending from the front surface of the head and comprising a second plurality of cleaning elements formed of the elastomeric material;
a first sleeve coupled to the head and extending from the front surface of the head, the first sleeve circumferentially surrounding a first portion of the tuft of cleaning elements, a second portion of the tuft of cleaning elements protruding beyond a distal end of the sleeve, and the first sleeve having a first height measured from the front surface of the head to a distal end of the first sleeve; and
a second sleeve coupled to the head and extending from the front surface of the head, the second sleeve circumferentially surrounding a portion of the second tuft of cleaning elements, the second sleeve having a second height measured from the front surface of the head to a distal end of the second sleeve;
wherein the first and second heights are different when the first and second tufts of cleaning elements are in a resting state with no external forces applied.

US Pat. No. 10,426,247

SURFBOARD CARRIER ASSEMBLY

1. A surfboard carrier assembly comprising:a first ring assembly including a first circular loop made of an elastic cord, a first hollow doughnut shaped cover made of a flexible fabric which encapsulates said first loop, and a first pair of straps affixed to said first cover at about diametrically opposed locations upon said first cover; and
a second ring assembly including a second circular loop made of an elastic cord, a second hollow doughnut shaped cover made of a flexible fabric which encapsulates said second loop, and a second pair of straps affixed to said second cover at about diametrically opposed locations upon said cover; and
wherein each of said circular loops has an elongation greater than the elongation of each of said covers.

US Pat. No. 10,426,246

COSMETIC CONTAINER

1. A cosmetic vessel comprising:an airless pump for discharging cosmetics to outside;
a discharge plate provided at one side of the airless pump from which the cosmetics is discharged, and including a plurality of discharge holes; and
a diffusion space configured to diffuse the cosmetics between the airless pump and the discharge holes to guide the cosmetics to the discharge holes,
wherein the discharge plate is made of metal, and is exposed to outside such that it may be contacted by a user's puff, and
the cosmetics is discharged from the airless pump as the discharge plate is pressed,
wherein the discharge holes do not coincide with an outlet of the airless pump, and
wherein a sealing is achieved by a close surface contact between a diffusion unit having the diffusion space and the discharge plate, and wherein the diffusion unit is provided between the airless pump and the discharge plate.

US Pat. No. 10,426,244

SYSTEM AND METHOD FOR A NAIL MANIPULATION

Finails OY, Espoo (FI)

1. A nail manipulation system for producing an object onto a nail,wherein the system comprises:
a shape information providing device for providing nail information of at least a shape of the nail to be manipulated, whereupon the system is configured to provide first controlling data based on said nail information, wherein the shape information providing device is a 3D-surface capturing device,
an object providing device for providing object data, comprising object data related to the object to be produced onto the nail, whereupon the system is configured to provide second controlling data based on said object data,
a manipulation device, wherein said manipulation device is configured to produce said object onto the nail to be manipulated, and
a controlling device for controlling operation of the manipulation device based on said first and second controlling data to produce said object onto the nail to be manipulated,
wherein the manipulation device comprises a dispenser configured to provide a nail manipulating medium following three dimensional shape of the nail to be manipulated according to a controlling instruction from the controlling device based at least on said first and second controlling data, wherein the nail manipulating medium is a gel, paint, lacquer or an adhesive.

US Pat. No. 10,426,243

HAIR FASTENER

TUNG HING PLASTIC MANUFAC...

1. An elongate hair fastener comprising a first member, a second member which together with the first member forms a locking means, and a third elongate member connecting the first member and the second member in that the first member and the second member are arranged at opposite ends of the third member, wherein the first member and the second member are made of a material stiffer than a material of the third member, and the material of the third member is elastic and stretchable under tension for maximizing holding capability of hair in use, wherein:said fastener is adapted to assume a first configuration in which the said first member and said second member are engaged before tying the hair wherein said first member and said second member are circumferentially aligned with each other, or a second configuration in which said first and second members are disengaged whereby removal of said fastener from the hair minimizes movement of said fastener along the length of the hair and thus eliminating or at least reducing frictional contact with the hair;
said first member and said second member are connected to the respective opposite ends of said third elongate member by overmoulding said elastic material over said first member and said second member thus integrally forming the opposite ends;
a surrounding structure of said first member defining an opening and a recess in communication with said opening, the recess smaller than the opening and adapted to receive a post extending from said second member when said first member engages and secures with said second member in the first configuration;
the opening and the recess comprising circle portions of two adjoining circles directly connected to each other such that arcs of the circle portions intersect with each other at opposite intersecting points such that intersecting portions of said circle portions curve from said intersecting points radially outwardly and form a ridge between said opening and said recess, said intersecting points are located further radially inwardly than a remainder of the surrounding structure defining the opening and the recess;
in the first configuration the post is fitted in the recess with said first member and said second member circumferentially aligned;
said first member and said second member are releasably engageable with each other by way of a mechanical interference fit in that, due to profiles of the two adjoining circles, the intersecting arcs and material characteristics of the surrounding structure, the engagement and securement of said first and second members is achieved independent of degree of tension of said elastic body, and disengagement of said first and second members is achieved by way of one hand operation of a user;
the opening comprising close to a full circle; and
the opening arranged closer to the third member of said fastener than the other circle(s).

US Pat. No. 10,426,240

OPERATING HANDLE DEVICE

DAIICHI KOSHO LTD., Toky...

1. An operating handle device comprising:at least one arm having an outer arm member and an inner arm member movable along a longitudinal direction of the outer arm member so as to be capable of being accommodated in the outer arm member, in which a pivoting mechanism is provided on the arm, and one end side in the longitudinal direction of the arm is attached to a mounted body, capable of pivoting movement through the pivoting mechanism;
an operated rod provided along the longitudinal direction of the arm and movable along the longitudinal direction of the arm together with the inner arm member;
a holding member attached to the inner arm member so as to be movable between a protruding position protruding to an outer side of the arm from an inner side of the arm and a retreated position retreated to the inner side of the arm, being configured to hold at least two modes that include a longest expanded mode of the arm in which the inner arm member protrudes to the maximum in the longitudinal direction of the arm with respect to the outer arm member at the protruding position so as to be engaged with the outer arm member and a shortest contracted mode of the arm in which the inner arm member is accommodated to the maximum in the longitudinal direction of the arm with respect to the outer arm member, and to release the holding of the longest expanded mode and the shortest contracted mode of the arm at the retreated position to release the locking to the outer arm member;
a holding spring body for urging the holding member toward the protruding position;
an engaging and disengaging member capable or being engaged with and disengaged from the pivoting mechanism, and capable of moving between a contact position where the engaging and disengaging member is brought into contact with the pivoting mechanism to hold the at least one arm non-rotational around the pivoting mechanism and a separated position where the engaging and disengaging member is separated from the pivoting mechanism to allow the at least one arm to be rotatable around the pivoting mechanism;
a locking spring body for urging the engaging and disengaging member toward the contact position; and
an operating member configured to be switchable among a holding release position where it is configured to move in one direction along the longitudinal direction of the at least one arm, an unlocking position where it is configured to move in the other direction along the longitudinal direction of the at least one arm, and a reference position between the holding release position and the unlocking position;
a linkage device for moving both the operated rod and the engaging and disengaging member in the other direction by linking the operated rod and the engaging and disengaging member to each other so as to change the engaging and disengaging member at the contact position to the separated position when the moving operation for moving the operating member in the other direction for a certain distance is performed;
wherein the operating member is configured to move the holding member to the retreated position and the engaging and disengaging member to the contact position with a movement to the holding release position, to move the holding member to the protruding position and the engaging and disengaging member to the separated position with a movement to the unlocking position, and to move the holding member to the protruding position and the engaging and disengaging member to the contact position with a movement to the reference position.

US Pat. No. 10,426,234

MULTI-ANGLE MULTI-FUNCTION UMBRELLA

19. A space-saver umbrella, comprising:a first post-stabilizing foot;
a second post-stabilizing foot;
a mounting plate,
for mounting on said first post-stabilizing foot, said second post-stabilizing foot, a fence, a balcony, a bumper, a hitch, a tailgate, or a table by being bolted thereon;
a lower post,
said fence-balcony-bumper-and-hitch-mountable plate attached to said lower post;
an upper post;
at least one inner core
for being attached to said
mounting plate and inserted into and bolted to said lower post and said upper post;
a multi-canopy-lifting-arm intersector
attached to said upper post;
a multi-canopy-supporting-arm intersector
slidably attached to said upper post;
a slidable multi-position handle
molded to said multi-canopy-supporting-arm intersector;
a height-adjusting spring-loaded rocker
sandwiched within said slidable multi-position handle;
a handle-locking rocker pin
attached to said height-adjusting spring-loaded rocker;
a plurality of handle-locking post holes respectively
drilled into said upper post;
a foldable multi-canopy-supporting arm
pivotably bolted to said multi-canopy-supporting-arm intersector;
a foldable multi-canopy-lifting arm
pivotably bolted to said multi-canopy-lifting-arm intersector and
said foldable multi-canopy-supporting arm;
a multi-canopy-hanging central tube;
a multi-canopy-deploying rope
threaded through said multi-canopy-supporting-arm intersector, and
threaded through said multi-canopy-hanging central tube;
a central-canopy intersector
attached to said multi-canopy-hanging central tube;
a plurality of central-canopy-supporting ribs respectively
attached to said central-canopy intersector;
a plurality of central-canopy-rib-raising arms respectively
pivotably attached to said central-canopy-supporting ribs;
a central canopy
attached to said central-canopy-supporting ribs;
a ring-canopy-rib intersector
connected to said multi-canopy-hanging central tube;
a plurality of first ring-canopy-supporting ribs respectively
pivotably connected to said ring-canopy-rib intersector and
pivotably attached to said central-canopy-rib-raising arms;
a plurality of second ring-canopy-supporting ribs;
a plurality of third ring-canopy-supporting ribs;
a plurality of first conjoined-double-coil caps respectively
slid on and pivotably connected to said first ring-canopy-supporting ribs and said second ring-canopy-supporting ribs;
a plurality of first conjoined-double-coil axles respectively
riveted on said first conjoined-double-coil caps, said first ring-canopy-supporting ribs, and said second ring-canopy-supporting ribs;
a plurality of first conjoined-double-coil springs respectively
springingly slid onto said first conjoined-double-coil axles;
a plurality of second conjoined-double-coil caps respectively
slid on and pivotably connected to said second ring-canopy-supporting ribs and said third ring-canopy-supporting ribs;
a plurality of second conjoined-double-coil axles respectively
riveted on said second conjoined-double-coil caps, said second ring-canopy-supporting ribs, and said third ring-canopy-supporting ribs;
a plurality of second conjoined-double-coil springs respectively
springingly slid onto said second conjoined-double-coil axles;
a ring-canopy-arm intersector
slidably attached to said multi-canopy-hanging central tube,
said multi-canopy-deploying rope
attached to said ring-canopy-arm intersector;
a plurality of ring-canopy-rib-raising arms respectively
foldably attached to said ring-canopy-arm intersector;
a ring canopy
attached to said first ring-canopy-supporting ribs and said second ring-canopy-supporting ribs;
four pockets,
said ring canopy having a plurality of corners and a plurality of inner edges,
said four pockets respectively sewn to said corners of said ring canopy;
a plurality of canopy-size-adjusting flaps respectively
sewn to said inner edges of said ring canopy; and
a plurality of canopy-size-adjusting holes respectively
drilled into said first ring-canopy-supporting ribs.

US Pat. No. 10,426,226

FOOTWEAR UPPER WITH DYNAMIC AND LOCK-OUT REGIONS

Under Armour, Inc., Balt...

1. An article of apparel comprising:a base layer; and
an auxetic layer coupled to the base layer, the auxetic layer comprising an auxetic structure defining a repeating pattern of perimeter walls and interior recesses, the auxetic layer including a first region and a second region, wherein each interior recess in the first region provides a void exposing the base layer, and wherein each interior recess in the second region is at least partially filled with a recess material.

US Pat. No. 10,426,224

THREE LAYER SHOE CONSTRUCTION WITH IMPROVED CUSHIONING, BREATHABILITY, FLEXIBILITY AND WATER DISPLACEMENT

Footwear Unlimited Inc., ...

1. A shoe construction comprising:an outsole having an exterior face, an interior face, a first sidewall, a medial side, a lateral side, an arch portion, a forefoot area, a midfoot area, and a hind foot area, the exterior face of the outsole including a first section, a second section, and a third section, the first section being located and positioned in the forefoot area and extends in from the medial side of the forefoot area to the lateral side of the midfoot area, the second section being located and positioned adjacent to the first section and includes a portion of the midfoot area and extends on opposite sides into the medial side of the forefoot area and into the lateral side of the hind foot area, the third section being located and positioned adjacent to the second section and extending from the hind foot area towards and into the midfoot area, the first section including a first plurality of non-linear grooves, a second plurality of curved grooves, a third plurality of straight grooves, and a plurality of circular shaped cavities, the second section including a first series of diagonal grooves and a second series of diagonal grooves, the third section including a first plurality of curved grooves, a second plurality of straight grooves, and a plurality of cavities, the first and second sections being separated by a first angled groove and the second and third sections being separated by a first non-linear groove, the first sidewall extending around a perimeter of the interior face of the outsole and including a lip, said first sidewall forming a first cavity located and positioned on the interior face, the interior face further including a raised angled projection and a raised non-linear projection, wherein the raised angled projection and the raised non-linear projection are located and positioned on the interior face in a corresponding relationship with the first angled groove and the first non-linear groove on the exterior face of the outsole;
a midsole having a proximal face, a distal face, a second sidewall, a forefoot area, a midfoot area and a hind foot area, the midsole having a first density in the forefoot area and a second density in the hind foot area, the second sidewall including a corresponding ridge for mating with the lip of the first sidewall of the outsole, the distal face of the midsole including a projected area, the projected area including a second angled groove and a second non-linear groove located and positioned in a corresponding relationship with the raised angled projection and the raised non-linear projection on the interior face of the outsole, the proximal face of the midsole having a second cavity; and
an insole having a top face and a bottom face, the top face of the insole including a plurality of raised projections;
the first cavity on the interior face of the outsole being shaped and dimensioned to receive the projected area on the distal face of the midsole and the second cavity on the proximal face of the midsole being shaped and dimensioned to receive the insole.

US Pat. No. 10,426,223

THREE LAYER SHOE CONSTRUCTION WITH IMPROVED CUSHIONING AND FLEXIBILITY

Footwear Unlimited Inc., ...

1. A shoe construction comprising:an outsole having an exterior face, an interior face, a medial side, a lateral side, an arch portion, a forefoot area, a midfoot area, and a hind foot area, the exterior face of the outsole including a first section and a second section, the first section being located and positioned at the arch portion of the outsole and extending into and towards the medial side of both the forefoot area and the hind foot area, the second section being located and positioned adjacent to the first section and extending into the forefoot and hind foot areas and into a portion of the midfoot area adjacent to the arch portion, the first section including a plurality of horizontal grooves and the second section includes a plurality of small apertures and a plurality of elongated apertures, the outsole having a first cavity located and positioned on the outsole's interior face;
a midsole having a proximal face, a distal face, a forefoot area, a midfoot area and a hind foot area, the midsole having a first density in the forefoot area and a second density in the hind foot area, the midsole having a projected area located and positioned on the midsole's distal face and a second cavity located and positioned on the midsole's proximal face; and
an insole having a top face, a bottom face, an outer perimeter, a heel portion, an arch portion, a hind foot area, a medial side, and a lateral side, the top face of the insole including a plurality of raised projections, the outer perimeter and a medial half of the arch portion being substantially smooth;
the first cavity on the interior face of the outsole being shaped and dimensioned to receive the projected area on the distal face of the midsole and the second cavity on the proximal face of the midsole being shaped and dimensioned to receive the insole.

US Pat. No. 10,426,218

RETRACTABLE HIGH HEEL SHOE

1. A retractable high heel shoe, comprising:a shoe having an upper portion extending perpendicularly upwards from a sole defining an interior volume configured to receive a foot therein;
a heel having a lower side affixed to the sole at a rear side of the shoe;
wherein the heel comprises a plurality of sections;
the plurality of sections in a telescopic configuration;
the plurality of sections configured to move between an extended position and a retracted position;
a button disposed on a front sidewall of the heel, wherein the button is affixed to a first end of an engagement member, the engagement member engaging the heel when in an engaged position and disengaging the heel when in a disengaged position.

US Pat. No. 10,426,202

SYSTEM FOR MINIMIZING MULTI-DIMENSIONAL DISPLACEMENT OF THE BODY

Recovery Force, LLC, Fis...

1. A garment for minimizing displacement of a part of a wearer's body, the garment comprising:a plurality of shape memory wires integrated into the garment, the plurality of wires arranged in relation to the part of the wearer's body experiencing displacement during physical activity of the wearer;
an accelerometer associated with the garment operable to generate data indicative of instantaneous accelerations of the wearer's body that can induce such displacement; and
a controller electrically connected to the plurality of shape memory wires and to the accelerometer, the controller including;
an electrical power supply for providing electrical power to the shape memory wires to cause a decrease in the length of the shape memory wires integrated into the garment to thereby tighten the garment about the part of the wearer's body, and
a processor operable to execute instructions for selectively providing electrical power to selected ones of the shape memory wires in response to data received from said accelerometer to thereby selectively tighten the garment about the part of the wearer's body.

US Pat. No. 10,426,193

CONTAINER

Nicoventures Holdings Lim...

1. A container including an elongate electronic nicotine delivery system or other flavored vapor delivery system, the container comprising:a rigid elongate body defining a chamber including an end having an opening;
an elongate electronic nicotine delivery system or other flavored vapor delivery system inserted into the chamber through said opening and supported in an upright position within the chamber, the elongate electronic nicotine delivery system having a controller;
a lid pivotally attached to said body to cover said opening in a closed position;
an over-center biasing mechanism configured to bias the lid toward the closed position until the lid has been pivoted into an intermediate position, beyond which the lid is biased towards an open position;
a switch for detecting whether the lid is in an open or closed position, wherein the switch is mechanically operated by movement of the lid for detecting whether the lid is in an open or closed position to generate a corresponding signal; and
a facility for recharging the elongate electronic nicotine delivery system or other flavored vapor delivery system;
wherein at the facility for recharging, the elongate electronic nicotine delivery system or other flavored vapor delivery system is configured to receive the signal at the controller.

US Pat. No. 10,426,187

CONTAINER SEALING DEVICE FOR HIGH-PRESSURE CHAMBER

UHDE HIGH PRESSURE TECHNO...

1. A device for high-pressure treatment of goods, the device comprising:a pressure vessel defining a high-pressure chamber therewithin;
a holding frame configured to hold the high-pressure chamber during an application of high pressure;
at least one end-side closure with a closure plug configured to seal the high-pressure chamber;
at least one hydraulic drive configured to move the closure plug into the chamber, the at least one hydraulic drive including a hydraulic cylinder with a hydraulic piston;
a support device that is removably positionable between the pressure vessel and the holding frame, wherein during the application of high pressure the support device transmits force between the at least one end-side closure and the holding frame;
a force transmission device in the form of a semicircular disk that absorbs axial forces applied to the at least one end-side closure by the application of high pressure; and
a pump that performs the application of high pressure to the high-pressure chamber when the hydraulic piston is inactive and when the support device is removably positioned between the closure plug and the force transmission device,
wherein the side of the force transmission device facing the high-pressure chamber includes a receptacle configured to accommodate the hydraulic cylinder with the hydraulic piston that is configured to act on the closure plug,
wherein the receptacle is aligned with an axis of the pressure vessel.

US Pat. No. 10,426,175

APPARATUS FOR ORIENTING SAUSAGES

VEMAG MASCHINENBAU GMBH, ...

1. An apparatus for orienting a plurality of sausages with respective curvatures, the apparatus comprising:a conveyor device configured to transport the sausages along a conveyor path, the conveyor device including a conveyor element on which the sausages can be placed at mutual spacings and with their longitudinal axis substantially perpendicular to a conveyor direction of the conveyor element; and
a turning device arranged over the conveyor element, the turning device configured to be brought into contact with each of the sausages and to orient the sausages oriented approximately transversely relative to the conveyor direction of the conveyor element in identical relationship in respect of the curvatures of the sausages.

US Pat. No. 10,426,162

INTERACTION BETWEEN ANTIMICROBIAL QUATERNARY COMPOUNDS AND ANIONIC SURFACTANTS

Ecolab USA Inc., Saint P...

1. An antimicrobial composition, comprising:a quaternary ammonium compound having the formula:

wherein groups R1, R2, R3, and R4 are alkyl groups that
are substituted, unsubstituted, saturated, unsaturated, branched, unbranched, cyclic, acyclic, and/or aromatic, each having less than a C20 chain length, and wherein X? is an anionic counterion; and
a C6-C18 akoxylated or un-alkoxylated linear or branched chain carboxylate, anionic polymer or anionic chelant, wherein the anionic chelant or polymer is an aminocarboxylate or derivative thereof, a phosphonic acid or phosphonate salt;
wherein the composition is a ready to use solution, or a solid or liquid concentrate that is soluble in water, has a pH of about 1 to about 12 and is substantially free of silanes, and oxidants.

US Pat. No. 10,426,152

SPOOL BRAKE DEVICE

SHIMANO INC., Sakai, Osa...

17. A dual bearing reel comprising:a reel body;
a spool coupled to the reel body;
a handle coupled to the reel body; and
a spool brake device comprising:
a brake unit configured to electrically brake the spool of the spool brake device;
a detector configured to detect a rotational speed of the spool; and
a controller configured to control a braking force of the brake unit,
wherein the braking force is controlled by the controller based on a detected rotational speed of the spool such that when the rotational speed of the spool is detected to be less than a predetermined rotational speed, the controller sets the braking force according to a regular braking mode having a regular braking force, and when the rotational speed of the spool is detected to be equal to or higher than the predetermined rotational speed, the controller sets the braking force according to an emergency braking mode having an emergency braking force, wherein the emergency braking force is greater than the regular braking force.

US Pat. No. 10,426,109

SYSTEMS AND METHODS FOR CULTIVATING AND DISTRIBUTING AQUATIC ORGANISMS

GreenOnyx LTD, Tel Aviv ...

1. A method for measuring the plant floating volume (PFV) for an aquatic plant culture, the method comprising:harvesting a portion of the aquatic plant culture;
delivering the portion of the aquatic plant culture to a holding chamber;
allowing the portion of the aquatic plant culture to float to the surface of a liquid within the holding chamber;
pumping liquid into the holding chamber to force the portion of the aquatic plant culture into a measurement tube;
allowing the portion of the aquatic plant culture to float within a defined location in the measurement tube; and
measuring the plant floating volume (PFV) of the portion of the aquatic plant culture in the measurement tube.

US Pat. No. 10,426,090

FORAGE HARVESTER MATERIAL APPLICATOR SYSTEM AND RELATED METHOD

Great Lakes Forage System...

1. A method of using an agricultural forage treatment applicator system to deliver a granular treatment material to forage during harvesting, the method comprising:harvesting forage from a field with a motorized forage harvester as the harvester moves in the field under power provided by a motor of the motorized forage harvester;
providing a vacuum and conveying harvested forage through a chute, the motorized forage harvester having an operator cab, within which an operator is located, disposed above the chute;
providing a bin mounted on the motorized forage harvester;
rotating a helical auger having a shaft rotatably mounted in a bottom of the bin to convey a granular treatment material in the bin toward an exit opening defined by the bin;
transferring the granular treatment material to a tube;
moving the granular treatment material through the tube with the vacuum toward a harvested forage moving in the chute so that the granular treatment material mixes with the harvested forage;
sensing with a sensor a rotation of the shaft as the shaft rotates to generate a first signal;
providing a controller in the operator cab, the controller including a manually adjustable actuator, the controller in communication with the sensor;
displaying a first indicia to the operator in the operator cab representative of a first RPM associated with the first signal;
displaying a second indicia to the operator in the operator cab representative of a measured harvested forage rate of forage material harvested by the motorized forage harvester;
adjusting the actuator of the controller to selectively change the first RPM to a second RPM so that the auger applies an amount of the granular treatment material to the harvested forage based on the second indicia representative of the measured harvested forage rate displayed inside the cab to the operator.

US Pat. No. 10,426,079

DECLUTCHING DEVICE FOR DISTRIBUTION ELEMENT AND SEED DRILL INCLUDING SUCH A DEVICE

KUHN S.A., Saverne (FR)

1. A declutching device for a seed drill distribution element, comprising:a locking element including first and second abutment surfaces; and
a support element including at least one lug on which the locking element is rotatably mounted,
wherein the lug is posited between the first abutment surface and the second abutment surface, and
wherein the locking element allows two stable positions relative to the support element and can be moved between the two stable positions, the two stable positions including:
an active position in which the first abutment surface of the locking element directly contacts the support element, the locking element being configured, when in the active position, to be able to declutch the distribution element, and
an inactive position in which the second abutment surface of the locking element directly contacts the support element.
US Pat. No. 10,426,822

CANCER VACCINE COMPOSITION

INTERNATIONAL INSTITUTE O...

1. A method of cancer treatment, comprising administering to an HLA-A*0206-positive person a composition comprising at least one of a modified peptide of the WT1187 peptide: Ser Leu Gly Glu Gln Gln Tyr Ser Val (SEQ ID NO: 2) or a modified peptide of the WT1126 peptide: Arg Met Phe Pro Asn Ala Pro Tyr Leu (SEQ ID NO: 3), wherein the modified peptide is a peptide comprising the amino acid residues at position 4 to 8 from the N terminus of the WT1187 or WT1126peptide and is immunogenic in HLA-A*0206-positive persons.
US Pat. No. 10,426,825

COMPOSITIONS, METHODS AND THERAPIES FOR ADMINISTERING ANTIGEN PEPTIDE

Kenichiro Hasumi, Tokyo ...

1. A composition to reduce inflammation in a patient with a Propionibacterium acnes infection, comprising:a peptide consisting of the amino acid sequence of SEQ ID NO:3; and
a TNF inhibitor.
US Pat. No. 10,428,362

ENZYMATIC HYDROLYSIS OF DISACCHARIDES AND OLIGOSACCHARIDES USING ALPHA-GLUCOSIDASE ENZYMES

E. I. DU PONT DE NEMOURS ...

1. A method of reducing the amount of a saccharide present in (i) a glucan synthesis reaction, or (ii) a fraction thereof, wherein said method comprises:contacting said glucan synthesis reaction or fraction thereof with an alpha-glucosidase enzyme, wherein the amount of said saccharide is reduced in said glucan synthesis reaction or said fraction thereof compared to the amount of said saccharide that was present prior to said contacting,
wherein said glucan synthesis reaction produces an insoluble alpha-glucan product, wherein at least 97% of the glycosidic linkages of said insoluble alpha-glucan product are alpha-1,3-glycosidic linkages, and
wherein said saccharide is a byproduct of said glucan synthesis reaction and is (a) leucrose or (b) a disaccharide or oligosaccharide that comprises at least one alpha-1,3 or alpha-1,6 glucosyl-glucose linkage.
US Pat. No. 10,429,389

METHOD FOR IDENTIFYING ALTERED LEUKOCYTE PROFILES

1. A method for identifying an altered leukocyte profile by pattern recognition comprising the steps of:a) receiving, at an input module executable on a processor, counts or relative percentages of more than two leukocyte cell types in a biological fluid from each of one or more individuals, said counts or percentages constituting input data points;
b) generating, using the processor, a plurality of combination data points, each combination data point being a value calculated from more than two input data points, each input data point corresponding to a distinct leukocyte cell type;
c) generating, using a processor, pairs of i) an input data point and a combination data point or ii) two combination data points;
d) generating, using a processor, a plurality of secondary data values from the pairs generated in c);
e) constructing, using a processor, a plurality of 3-D plots, each plot having a plurality of plot points, each plot point having three coordinates, wherein each coordinate is an input data point or a secondary data value , and at least one of the coordinates is a secondary data value; and
f) performing, using the processor, pattern recognition of: perpendicular subsets of the plot points, a bifurcated subset of the plot points, two or more non-overlapping subsets of the plot points, or combinations thereof, thereby selecting the 3-D plots useful for identifying an altered leukocyte profile.
US Pat. No. 10,431,439

TANTALUM SPUTTERING TARGET

1. A disk-shaped tantalum sputtering target having a recrystallized structure and a diameter of 450 mm? and containing niobium and tungsten as essential components each in an amount of 1 massppm or more and 5 massppm or less, and having a purity of 99.9999% or higher excluding niobium, tungsten and gas components, wherein an average crystal grain size of the tantalum sputtering target is 50 ?m or more and 150 ?m or less, variation of the crystal grain size is 20% or less, and variation of contents of the niobium and tungsten in the tantalum sputtering target is 30% or less, and wherein the variation of the crystal grain size is defined as a percentage determined by measuring the crystal grain size of the tantalum sputtering target at a total of 9 points, including a center point of the target, four points at half radius of the target, and four points adjacent an outer periphery of the target, and by calculating a variation thereof with a formula of ((maximum value?minimum value)/(maximum value+minimum value))×100.
US Pat. No. 10,429,399

PROCESS CONTROL FOR INCREASED ROBUSTNESS OF GENETIC ASSAYS

Good Start Genetics, Inc....

1. A method for processing a biological sample, the method comprising:obtaining a sample comprising at least one cell biopsied from an embryo in a solution of 2-3 ?l of liquid;
contacting the sample with an indicator dye comprising cresol red that provides a visual indication that the sample is frozen and within a specific, pre-defined pH range;
exposing the sample to a freezing temperature;
determining based on the visual indication that the sample is frozen; and
performing a preimplantation genetic screening procedure comprising:
using a camera controlled by computer software to evaluate a color of the sample;
confirming with the computer software that the color indicates that the sample remains frozen;
contacting the sample with an alkaline lysis solution followed by contacting the sample with an acid to achieve a neutral pH;
using the camera and the computer software to evaluate a color of the sample and confirm that the sample has a neutral pH; and
analyzing a karyotype of the at least one biopsied cell in the sample.
US Pat. No. 10,428,378

SEQUENCING METHOD FOR RAPID IDENTIFICATION AND PROCESSING OF COGNATE NUCLEOTIDE PAIRS

OMNIOME, INC., San Diego...

1. A method of determining the identity of first and second correct nucleotides respectively comprising bases complementary to the next two bases of a template strand immediately downstream of a primer of a primed template nucleic acid molecule, said method comprising the steps of:(a) conducting a plurality of cycles of contacting a first primed template nucleic acid molecule with a reaction mixture comprising a polymerase and, for each cycle, a different test nucleotide, and removing any polymerase and nucleotide that may have bound to the first primed template nucleic acid molecule,
wherein the polymerase does not incorporate any of the different test nucleotides into the primer of the first primed template nucleic acid molecule during any of the plurality of cycles;
(b) measuring, for the cycles in step (a), signals indicating the magnitudes of formation of stabilized ternary complexes comprising binding of the first primed template nucleic acid molecule to the polymerase and the different test nucleotides; and
(c) determining the identities of the first correct nucleotide downstream of the primer, and the second correct nucleotide downstream of the primer using the measured signals from step (b), wherein the test nucleotide associated with the highest magnitude of stabilized ternary complex formation is identified as the first correct nucleotide downstream of the primer, and the test nucleotide associated with the second-highest magnitude of stabilized ternary complex formation is identified as the second correct nucleotide downstream of the primer.
US Pat. No. 10,426,847

METHOD FOR THE TREATMENT OF MALIGNANCIES

OncoSec Medical Incorpora...

1. A method of treating a subject having a treatment-refractory, cutaneous or subcutaneous, cancerous tumor, the method comprising:a) injecting the treatment-refractory cutaneous or subcutaneous cancerous tumor with an effective dose of at least one plasmid coding for at least one immunostimulatory cytokine;
b) administering electroporation therapy to the tumor; and
c) administering an effective dose of an immune checkpoint inhibitor to the subject.
US Pat. No. 10,428,384

BIOMARKERS FOR POST-TRAUMATIC STRESS STATES

Northwestern University, ...

1. A panel of biomarkers consisting of an isolated set of 100 or fewer full-length cDNA biomarkers, wherein said isolated set includes ALOX15, EIF4G2, and PRDX6 full-length cDNA biomarkers.
US Pat. No. 10,428,129

RECOMBINANT PROTEIN

UBI PHARMA INC., Hukou T...

1. A recombinant protein, comprising an erythropoietin and a highly glycosylated peptide, wherein the highly glycosylated peptide comprises the sequence of SEQ ID NO: 1 and/or 2.
US Pat. No. 10,427,106

ASYMMETRIC MEMBRANES

Georgia Southern Universi...

1. An asymmetric membrane comprising: a) a first portion comprising nanopores; b) a second portion, adjacent to the first portion, comprising macrovoids; wherein the membrane has a total thickness of at least about 1 m; wherein each portion comprises amorphous carbon and paracrystalline carbon, wherein each portion comprises a lithium storage material; and wherein the amorphous carbon comprises a carbonized cellulose acetate, carbonized polyacrylonitrile, carbonized polysulfone, carbonized polyamide.
US Pat. No. 10,428,130

PURIFICATION OF BONE MORPHOGENETIC PROTEINS (BMPS)

ISTITUTO BIOCHIMICO ITALI...

1. A method of purifying a secreted TGF-? superfamily protein, wherein the secreted TGF-? superfamily protein is a bone morphogenetic protein (BMP), said method comprising:i. contacting a solution containing the secreted TGF-? superfamily protein with a Hydrophobic Charge Interaction Chromatography (HCIC) resin for obtaining a first eluate containing the TGF-? superfamily protein, wherein the first eluate containing the secreted TGF-? superfamily protein is eluted from the HCIC resin using an elution Glycine buffered solution; and
ii. contacting the first eluate containing the secreted TGF-? superfamily protein with a cation-exchange chromatography resin for obtaining a second eluate containing the secreted TGF-? superfamily protein.
US Pat. No. 10,427,109

COMPOSITE SEMIPERMEABLE MEMBRANE AND PRODUCTION THEREOF

TORAY INDUSTRIES, INC., ...

1. A composite semipermeable membrane comprising:a substrate;
a porous supporting layer formed on the substrate; and
a separation functional layer formed on the porous supporting layer, the separation functional layer having a rear surface facing the porous supporting layer and a front surface on an opposite side,
wherein the separation functional layer contains crosslinked wholly aromatic polyamide as a main component and contains carboxy groups,
a ratio of (molar equivalent of the carboxy groups)/(molar equivalent of amide groups) in functional groups contained in the separation functional layer crosslinked wholly aromatic polyamide is 0.40 or more and 0.60 or less, wherein the ratio is obtained using 13C solid-state NMR measurement according to the CP/MAS method and the DD/MAS method, wherein from the obtained spectra, for each peak derived from a carbon atom to which each functional group is bonded, peak division is performed and the amount of the functional group is quantified from the area of the divided peak,
an average ratio of oxygen atoms/nitrogen atoms in front and rear surfaces of the separation functional layer is 0.80 or more and 0.95 or less, wherein the average ratio is obtained by using X-ray photoelectron spectroscopy analysis,
the separation functional layer is coated with a hydrophilic polymer, and
the separation functional layer contains phenolic hydroxyl groups such that a ratio of (molar equivalent of the phenolic hydroxyl groups)/(molar equivalent of the amide groups) is 0.10 or less, wherein the ratio is obtained using 13C solid-state NMR measurement according to the CP/MAS method and the DD/MAS method, wherein from the obtained spectra, for each peak derived from a carbon atom to which each functional group is bonded, peak division is performed and the amount of the functional group is quantified from the area of the divided peak.
US Pat. No. 10,428,391

METHOD TO USE VIRAL AND HOST METHYLATION MARKERS FOR CERVICAL CANCER SCREENING AND TRIAGE IN LIQUID PREP, SERUM/PLASMA, AND URINE: PCR AND SEQUENCING BASED PROCESS METHODS

The Johns Hopkins Univers...

1. A method for triaging a human papillomavirus (HPV)-positive woman into colposcopy, the method comprising:(a) selecting a HPV-positive woman testing positive for one or more high risk types of HPV;
(b) obtaining nucleic acid from a test sample from a liquid prep, plasma, serum or urine of the selected HPV-positive woman;
(c) performing bisulfite modification to the nucleic acid from the test sample to produce a bisulfite modified nucleic acid;
(d) determining in the bisulfite modified nucleic acid from (c) a promoter methylation level of the promoter regions of the group of genes comprising ZNF516, FKBP6, and INTS1 and HPV gene HPV16-L1 using quantitative real-time methylation specific PCR (QMSP) and primers and/or probes are selected from the group consisting of SEQ ID NOS: 1-12 that exhibit increased promoter methylation in women having CIN12+ lesions as compared to women having no intraepithelial lesions or malignancy (NILM);
(e) triaging the HPV-positive woman into colposcopy when the level of promoter methylation of the group of genes is increased relative to the level of promoter methylation of the group of genes in a reference sample obtained from women having NILM; and
(f) performing a colposcopy.
US Pat. No. 10,428,136

I DOMAIN CHIMERIC ANTIGEN RECEPTOR SPECIFIC TO ICAM-1

1. A Chimeric antigen receptor (CAR) comprising from N-terminus to C-terminus:(i) an I domain of the ?L subunit of human lymphocyte function-associated antigen-1,
(ii) a transmembrane domain,
(iii) at least one co-stimulatory domains, and
(iv) an activating domain, wherein the I domain binds ICAM-1 at an affinity between about 145 nM to about 20 ?M, and the I domain comprises the sequence of 130-310 amino acids of SEQ ID NO: 1, with one mutation of F292A, F292S, L289G, or F265S.
US Pat. No. 10,428,393

CORN EVENT 5307

Syngenta Crop Protection ...

1. A method of detecting the presence of a nucleic acid molecule that is unique to event 5307 in a sample comprising corn nucleic acids, the method comprising:a) isolating a nucleic acid molecule from corn;
b) combining the nucleic acid molecule with a pair of nucleic acid primer sequences, wherein the first primer sequence is selected from any one of SEQ ID NO. 8 through SEQ ID NO: 14 or SEQ ID NO: 69 through SEQ ID NO: 72, or their complements; and the second primer sequence is selected from any one of SEQ ID NO: 15 through SEQ ID NO: 68, or their complements;
c) performing a nucleic acid amplification reaction which results in an amplicon; and
d) detecting the amplicon.
US Pat. No. 10,428,140

ANTI-EPHA4 ANTIBODY

1. An anti-EphA4 antibody or an EphA4-binding fragment thereof, comprising a heavy chain variable region and a light chain variable region,wherein the heavy chain variable region comprises
(a) CDR-H1 comprising the amino acid sequence represented by or SEQ ID NO: 27;
(b) CDR-H2 comprising the amino acid sequence represented by or SEQ ID NO: 29; and
(c) CDR-H3 comprising the amino acid sequence represented by SEQ ID NO: 30; and
wherein the light chain variable region comprises
(d) CDR-L1 comprising the amino acid sequence represented by SEQ ID NO: 31;
(e) CDR-L2 comprising the amino acid sequence represented by SEQ ID NO: 32; and
(f) CDR-L3 comprising the amino acid sequence represented by SEQ ID NO: 33.
US Pat. No. 10,428,141

COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ANTI-ROR1 IMMUNOTHERAPY

LENTIGEN TECHNOLOGY, INC....

1. An isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR) comprising at least one extracellular antigen binding domain comprising a ROR1 antigen binding domain encoded by a nucleotide sequence comprising SEQ ID NO: 1, or SEQ ID NO: 7, a transmembrane domain comprising CD8 transmembrane domain, an intracellular signaling domain comprising a functional signaling domain of 4-1BB and a CD3 zeta intracellular domain.
US Pat. No. 10,428,142

MULTIPARTITE SIGNALING PROTEINS AND USES THEREOF

bluebird bio, Inc., Camb...

1. An isolated non-natural cell comprising:(a) a first nucleic acid molecule encoding a first fusion protein comprising a first multimerization domain comprising an FRB T2098L polypeptide, a CD8a transmembrane domain, a costimulatory domain of 4-1BB, and an actuator domain of CD3, wherein the first multimerization domain localizes extracellularly when the first fusion protein is expressed; and
(b) a second nucleic acid molecule encoding a second fusion protein comprising a binding domain comprising a single chain antibody variable region (scFv) specific for CD19 or B cell maturation antigen (BCMA), a second multimerization domain comprising an FKBP12 polypeptide, and a CD4, a CD154 or a CD71 transmembrane domain, wherein the second multimerization domain localizes extracellularly when the first fusion protein is expressed;
wherein the first fusion protein and the second fusion protein are each expressed as separate fusion proteins and form a polypeptide complex on the non-natural cell surface in the presence of a bridging factor, rapalog AP21967; and
wherein the bridging factor is associated with and disposed between the first and second multimerization domains.
US Pat. No. 10,426,865

ABSORBENT PAD THAT INCLUDES A FATTY ACID COMPOSITION FOR ODOR CONTROL

BioNutraTech, Inc., Hous...

1. An absorbent pad, comprising:a batt of cellulose fibers;
superabsorbent particles intermixed within the batt of cellulose fibers; and
an odor control material intermixed within the batt of cellulose fibers, wherein the odor control material is a particulate material that is a composite of one or more fatty acids mixed with a source of nitrogen, a source of phosphorus, and a source of iron.
US Pat. No. 10,428,145

PD-1 BINDING PROTEINS AND METHODS OF USE THEREOF

Celgene Corporation, Sum...

1. An antibody or antigen-binding fragment thereof that binds to PD-1, wherein the antibody or antigen-binding fragment comprises:a light chain variable region (VL) comprising:
a VL complementarity determining region 1 (CDR1) comprising SEQ ID NO:1,
a VL CDR2 comprising SEQ ID NO:2, and
a VL CDR3 comprising SEQ ID NO:3; and
a heavy chain variable region (VH) comprising:
a VH CDR1 comprising SEQ ID NO:4,
a VH CDR2 comprising SEQ ID NO:5, and
a VH CDR3 comprising SEQ ID NO:6.
US Pat. No. 10,426,868

METHOD FOR PREPARING AN ANIMAL DECELLULARIZED TISSUE MATRIX MATERIAL AND A DECELLULARIZED TISSUE MATRIX MATERIAL PREPARED THEREBY

Beijing Ruijian Gaoke Bio...

1. A method for manufacturing an animal acellular tissue matrix material, comprising the steps of:(1) collecting a raw material of an animal tissue, wherein the animal tissue is washed to remove blood and dirt, and cut into a tissue material having a length, a width and a height of the desired specification and dimension, and then the tissue material is preserved at a low temperature below freezing;
(2) thawing slowly, and rehydrating the tissue material from step (1) in normal saline containing gentamicin;
(3) disinfecting and sterilizing the tissue material from step (2) in a moderate alkaline solution, then rinsing the tissue material with sterile pure water, and adjusting the pH of the tissue material to be neutral, wherein the moderate alkaline solution is a sodium bicarbonate or sodium hydroxide solution with a pH of 10.5 to 11.5 or an ammonia hydroxide solution with a concentration of 0.1%, wherein in the step of disinfection and sterilization, the rehydrated tissue material is soaked in the moderate alkaline solution for 24 hours to 48 hours with slow shaking;
(4) decellularizing and washing the tissue material from step (3),
wherein the decellularizing comprises rinsing the disinfected, sterilized and rinsed tissue material in normal saline containing 2.0 mmol/L of calcium chloride, 2.0 mmol/L of magnesium chloride and 100 mg/L of gentamicin at room temperature for 1˜3 hours, and then adding a dispase solution to remove the cells, wherein the dispase solution is a neutral dispase solution containing 1 mmol/L to 20 mmol/L of calcium chloride, 1 mmol/L to 20 mmol/L of magnesium chloride and 50 units/L to 400 units/L of dispase, and the tissue material is soaked in the neutral dispase solution at 37° C. for 24 hours to 36 hours with slow shaking;
wherein the washing comprises washing with a first detergent solution at 37° C. for 12 hours to 18 hours with slow shaking and washing with a second detergent solution at room temperature for 24 hours to 36 hours with slow shaking, wherein the first detergent solution is prepared by dissolving polyethylene glycol tert-octylphenyl ether, at a concentration of 0.5%, in a buffer solution of hydroxyethylpiperazine ethane sulfonic acid with a pH between 7.0 and 8.0; and the second detergent solution is prepared by dissolving sodium deoxycholate, at a concentration of 1.0%, in phosphate buffer solution with a pH between 7.2 and 7.8;
(5) digesting DNA components of the animal tissue, wherein the animal tissue is then rinsed with normal saline;
(6) digesting ?-Gal antigen of the animal tissue, wherein the animal tissue is then rinsed with a 2% to 5% high concentration sodium chloride solution, and then rinsed with normal saline, and when the raw material of the animal tissue has been improved by genetic engineering to have no ?-Gal antigen is selected, step (6) is omitted and step (7) is directly performed;
(7) inactivating any viruses in the tissue material and then rinsing the tissue material;
(8) packaging and sealing the tissue material under an aseptic condition; and
(9) terminal sterilization treatment of the tissue material to obtain the animal acellular tissue matrix material;
wherein an enzymatic method is used to remove cell components and ?-Gal antigen and improve the flexibility of a scaffold.
US Pat. No. 10,428,148

ANTI-ALK2 ANTIBODY

Saitama Medical Universit...

1. A monoclonal antibody or an antigen-binding fragment thereof which inhibits activin like kinase 2 (ALK2)-mediated bone morphogenetic proteins (BMP) signal transduction and specifically binds to a polypeptide sequence consisting of at least 7 amino acids present in any one of the following amino acid sequences (a) to (d):(a) the amino acid sequence of SEQ ID NO: 84;
(b) the amino acid sequence consisting of amino acid position numbers 21 to 123 of the amino acid sequence of SEQ ID NO: 84;
(c) the amino acid sequence of SEQ ID NO: 86; and
(d) the amino acid sequence consisting of amino acid position numbers 21 to 123 of the amino acid sequence of SEQ ID NO: 86,wherein the monoclonal antibody or antigen binding fragment comprises a heavy chain variable region having complementarity determining region (CDR) H1, CDRH2, and CDRH3 and a light chain variable region having CDRL1, CDRL2, and CDRL3, wherein a set of the amino acid sequences of CDRH1, CDRH2, and CDRH3 and the amino acid sequences of CDRL1, CDRL2, and CDRL3 is selected from the group consisting of:(1) SEQ ID NO: 72 for CDRH1, SEQ ID NO: 73 for CDRH2, and SEQ ID NO: 74 for CDRH3, and SEQ ID NO: 75 for CDRL1, SEQ ID NO: 76 for CDRL2, and SEQ ID NO: 77 for CDRL3;
(2) SEQ ID NO: 59 for CDRH1, SEQ ID NO: 60 for CDRH2, and SEQ ID NO: 61 for CDRH3, and SEQ ID NO: 62 for CDRL1, SEQ ID NO: 63 or 71 for CDRL2, and SEQ ID NO: 64 for CDRL3;
(3) SEQ ID NO: 78 for CDRH1, SEQ ID NO: 79 for CDRH2, and SEQ ID NO: 80 for CDRH3, and SEQ ID NO: 81 for CDRL1, SEQ ID NO: 82 for CDRL2, and SEQ ID NO: 83 for CDRL3; and
(4) SEQ ID NO: 65 for CDRH1, SEQ ID NO: 66 for CDRH2, and SEQ ID NO: 67 for CDRH3, and SEQ ID NO: 68 for CDRL1, SEQ ID NO: 69 for CDRL2, and SEQ ID NO: 70 for CDRL3.
US Pat. No. 10,428,153

HUMAN ANTI TSHR ANTIBODIES

RSR Ltd., Lancaster (GB)...

1. An isolated human monoclonal or recombinant antibody or fragment thereof that binds to the TSH receptor and stimulates the TSH receptor, wherein the antibody or fragment thereof comprises:an antibody VL domain having the amino acid sequence shown in residues 1-129 of SEQ ID NO:33; and
an antibody VH domain having the amino acid sequence shown in residues 1-141 of SEQ ID NO:15.
US Pat. No. 10,428,155

TRISPECIFIC ANTIBODIES

Xencor, Inc., Monrovia, ...

1. A tetravalent, trispecific antibody comprising:a) a first monomer comprising from N to C-terminus, a first variable heavy domain, a first CH1 domain, an optional domain linker, a first scFv domain, an optional domain linker, a hinge domain and a first variant Fc domain comprising a first CH2-CH3 domain;
b) a second monomer comprising from N to C-terminus, a second variable heavy domain, a second CH1 domain, an optional domain linker, a second scFv domain, an optional domain linker, a hinge domain and a second variant Fc domain comprising a second CH2-CH3 domain; and
c) a first light chain comprising a constant light domain and a first variable light domain; and
d) a second light chain comprising a constant light domain and a second variable light domain;
wherein said first variable heavy domain and said first variable light domain forms a first antigen binding domain that binds a first antigen, said second variable heavy domain and said second variable light domain forms a second antigen binding domain that binds said first antigen, said first scFv domain forms a third antigen binding domain that binds a second antigen, and said second scFv domain forms a fourth antigen binding domain that binds a third antigen,
wherein said first scFv domain binds CD8 and comprises a first scFv variable heavy domain comprising SEQ ID NO: 127 and a first scFv variable light domain comprising SEQ ID NO; 131,
wherein said second scFv domain binds CD3 and comprises a second scFv variable heavy domain comprising SEQ ID NO: 46 and a second scFv variable light domain comprising SEQ ID NO: 50,
wherein said first variable heavy domain and said first variable light domain comprise SEQ ID NOs: 73 and 77, respectively or SEQ ID NOs: 91 and 95, respectively,
wherein said second variable heavy domain and said second variable light domain comprise SEQ ID NOs: 73 and 77, respectively or SEQ ID NOs: 91 and 95, respectively, and
wherein said first and said second variant Fc domains comprise a pair of sets of amino acid substitutions selected from the group consisting of S364K/E357Q: L368D/K370S; L368D/K370S: S364K; L368E/K370S: S364K; T411T/E360E/Q362E: D401K; L368D/K370S: S364K/E357L and K370S: S364K/E357Q.
US Pat. No. 10,428,414

CARBURIZED COMPONENT

DAIDO STEEL CO., LTD., A...

1. A carburized part having a total amount of TiC, AlN and ZrC, which are precipitate particles, of 4.5×10?1° mole or less per 1 mm2 of grain boundary area of prior austenite grains after carburization, which is formed by processing a steel material into a shape of a part and performing a carburizing treatment on the steel material, the steel material having a composition consisting of, in terms of % by mass:0.10% to 0.30% of C;
0.01% to 0.49% of Si;
0.65% to 1.50% of Mn;
0.01% to 0.10% of S;
0.03% or less of P;
0.05% to 1.00% of Cu;
0.05% to 1.00% of Ni;
0.01% to 2.00% of Cr;
0.01% to 0.50% of Mo;
0.001% or less of Nb;
0.005% to 0.050% of s-Al;
0.005% to 0.030% of N; and
one or two elements selected from
0.001% to 0.150% of Ti and
0.001% to 0.300% of Zr,
and optionally:
0.001% to 0.010% of B,
with the remainder being Fe and inevitable impurities,
wherein
[Ti], [Zr] and [N] which respectively represent contents of Ti, Zr, and N, in mole/g, satisfy the following equation (1):
|[Ti]/47.9+[Zr]/91.2?[N]/14|/100?3.5×10?6 mole/g  Equation (1);
wherein at least one element selected from Ti and Zr combines with N included in the steel at the time of forging of the steel, and crystallizes in a form of at least one of TiN and ZrN having no contribution to a pinning of crystal grain boundaries to prevent AlN having a pinning action from being precipitated, and
a structure thereof after the carburization is a well-ordered grain structure having a uniform crystal grain size in which an average crystal grain size of the prior austenite grain is greater than 3 and 7.5 or less, and a crystal grain size difference of the prior austenite grains is 6 or less.
US Pat. No. 10,428,161

METHOD FOR PRODUCING MODIFIED SOLUTION-POLYMERIZED DIENE RUBBER TO BE BLENDED WITH SILICA, AND RUBBER COMPOSITION CONTAINING SAME

ERIC Inc., Tokyo (JP)

1. A method for producing a modified solution polymerized diene rubber, comprising:i) initiating polymerization of a conjugated diene compound and an aromatic vinyl compound in a hydrocarbon by an organolithium compound or in the co-presence of a secondary amine compound;
ii) after completion of the polymerization, adding a tin compound of formula (1) to treat the diene rubber so that the content of three or more branched component is 5 to 30%;
iii) adding the silane compound of formula (2), whereby the content of two-branched component of the diene rubber is less than 30%; and
iv) steam coagulating and drying the obtained polymer composition, so that the content of two or more branched component increases by 10 to 50% with respect to the state before steam coagulation, and wherein the modified solution polymerized diene rubber is thermally stabilized to the extent that the Mooney viscosity (a) of the rubber measured after said coagulation and drying, varies by not more than 10 from the Mooney viscosity (b) of the rubber measured when it is further heat-treated for 20 minutes with a subsequent 130° C. roll mill,
[Formula 1]
(R1)n—Sn—(X)4-n  Formula (1)wherein R1 is an alkyl group, an allyl group or aromatic group, wherein a carbon number of R1 is 1 to 12 carbon atoms, X is a halogen compound of iodine, bromine or chlorine, n is an integer of 0 or 1,[Formula 2]
(R2O)n—Si—(R3)4-m  Formula (2)
wherein R2 is an alkyl group, an allyl group or an aromatic group, wherein a carbon number of R2 is 1 to 12, or an alkyl group, an aromatic group or an allyl group containing a nitrogen atom in these functional groups, R3 is a an alkyl group, an allyl group or aromatic group, wherein a carbon number of R3 is 1-12, or an alkyl group, an aromatic group or allyl group, containing an oxygen atom and/or a nitrogen atom in these functional groups, m is an integer of 2 to 4.
US Pat. No. 10,426,120

MAIZE HYBRID X80M877

PIONEER HI-BRED INTERNATI...

1. A seed of hybrid maize variety X80M877, representative seed produced by crossing a first plant of variety PH4358 with a second plant of variety PH42RF, wherein representative seed of the varieties PH4358 and PH42RF have been deposited under ATCC Accession Numbers PTA-124774 and PTA-124807, respectively.
US Pat. No. 10,426,124

SOYBEAN CULTIVAR 179565921658

SGI GENETICS, INC., St. ...

1. A seed of soybean cultivar 179565921658, wherein a sample of seed of soybean cultivar 179565921658 is deposited under NCIMB No. 43419.
US Pat. No. 10,428,172

REACTIVE POLYURETHANE ADHESIVE COMPOSITION, POLYURETHANE PREPOLYMER, AND FLEXIBLE LAMINATES INCLUDING THE SAME

H.B. Fuller Company, St....

1. A polyurethane adhesive composition comprising:a polyurethane prepolymer comprising the reaction product of
a first polyol component comprising
glycerol monostearate, and
a hydroxy functional triglyceride, and
polyisocyanate; and
a second polyol.
US Pat. No. 10,426,125

SOYBEAN CULTIVAR 179609121658

SGI GENETICS, INC., St. ...

1. A seed of soybean cultivar 179609121658, wherein a sample of seed of soybean cultivar 179609121658 is deposited under NCIMB No. 43418.
US Pat. No. 10,428,175

TOUGHENING OF EPOXY THERMOSETS

Drexel University, Phila...

18. A composite as claimed in claim 16 comprising one or more additives selected from colorants, pigments, carbon black, impact modifiers, antioxidants, stabilizers, flame retardants, reheating aids, crystallization aids, oxygen scavengers, plasticizers, flexibilizers, nucleating agents, foaming agents, and mold release agents.
US Pat. No. 10,428,186

MULTI-COMPONENT PARTICLES COMPRISING INORGANIC NANOPARTICLES DISTRIBUTED IN AN ORGANIC MATRIX AND PROCESSES FOR MAKING AND USING SAME

SICPA HOLDING SA, Prilly...

1. A process for making multi-component particles comprising inorganic nanoparticles distributed in an organic matrix, the process comprising the steps of:(a) generating an aerosol comprising droplets, wherein the droplets comprise a liquid vehicle, an inorganic nanoparticle precursor and an organic matrix precursor; and
(b) removing at least a portion of the liquid vehicle from the droplets under conditions effective to convert at least a portion of the organic matrix precursor to the organic matrix and to convert at least a portion of the inorganic nanoparticle precursor to the inorganic nanoparticles distributed in the organic matrix.