US Pat. No. 10,190,214

DEPOSITION APPARATUS AND DEPOSITION SYSTEM HAVING THE SAME

ASM IP Holding B.V., Alm...

1. A deposition apparatus comprising:a substrate support having a main surface on which a substrate is placed;
a body disposed on the main surface of the substrate support and comprising a hollow portion having an exposed upper portion;
a plasma electrode unit provided at an inner circumferential surface of the body and defining an upper space and a lower space of the hollow portion, the upper space being filled with an external gas; and
a gas supply unit supplying process gas to the plasma electrode unit,
wherein the body defines a gas exhaust channel therein, the gas exhaust channel extending from the lower space to an exhaust outlet provided at a top of the body, and
wherein the body defines at least one groove therein that is formed on the bottom surface of the body, and the at least one groove is configured to connect an outer region of the body and the gas exhaust channel.

US Pat. No. 10,190,213

DEPOSITION OF METAL BORIDES

ASM IP Holding B.V., Alm...

1. A method of forming a film having a metal boride comprising:providing a substrate for processing in a reaction chamber;
performing a metal precursor deposition onto the substrate, the performing the metal precursor deposition step comprises:
pulsing a metal precursor onto the substrate; and
purging an excess of the metal precursor from the reaction chamber; and
performing a decaborane precursor deposition onto the substrate, the performing the decaborane precursor deposition step comprises:
pulsing a decaborane precursor onto the substrate, wherein prior to entering into the reaction chamber, the decaborane precursor is kept at a temperature not exceeding 65° C.; and
purging an excess of the decaborane precursor from the reaction chamber;
wherein the metal precursor comprises one of: titanium tetrachloride (TiCl4), niobium pentachloride (NbCl5), tantalum pentafluoride (TaF5), and niobium pentafluoride (NbF5) and wherein prior to entering the reaction chamber, the metal halide is kept at temperature ranging between 50° C. and 120° C.;
wherein a reaction between the metal halide precursor and the decaborane precursor forms a film comprising at least one of: titanium boride (TiB), tantalum boride (TaB), or niobium boride (NbB);
wherein the metal precursor deposition step is repeated a predetermined number of times; and
wherein the decaborane precursor deposition step is repeated a predetermined number of times.

US Pat. No. 10,190,212

BROMINE-SENSITIZED SOLAR PHOTOLYSIS OF CARBON DIOXIDE

1. A composition of matter comprising a chemical compound of the formula C2O4Br4.

US Pat. No. 10,190,210

NEAR-FIELD TRANSDUCER HAVING AT LEAST ONE SECONDARY ATOM

Seagate Technology LLC, ...

1. A device having an air bearing surface (ABS), the device comprising:a near field transducer, the near field transducer comprising a peg and a disc, the peg having a region adjacent the ABS, the peg comprising:
a plasmonic material selected from gold (Au), silver (Ag), copper (Cu), ruthenium (Ru), rhodium (Rh), aluminum (Al), or combinations thereof; and
at least one other secondary atom selected from germanium (Ge), tellurium (Te), aluminum (Al), antimony (Sb), tin (Sn), mercury (Hg), indium (In), zinc (Zn), iron (Fe), copper (Cu), manganese (Mn), silver (Ag), chromium (Cr), cobalt (Co), and combinations thereof, the concentration of the at least one secondary atom being not less than 0.001 at % and not greater than 30 at % in the peg.

US Pat. No. 10,190,209

PVD APPARATUS AND METHOD WITH DEPOSITION CHAMBER HAVING MULTIPLE TARGETS AND MAGNETS

Taiwan Semiconductor Manu...

1. A system comprising:a deposition chamber with a target arrangement including a plurality of target assemblies therein, each said target assembly including a target member and at least one magnet having a north pole and a south pole oriented in a plane parallel to a surface of said target member, wherein each of the at least one magnets is an annular magnet having said north pole concentrically positioned within said south pole, each said target assembly having a separately controllable power source.

US Pat. No. 10,190,206

DUAL PHASE MAGNETIC MATERIAL COMPONENT AND METHOD OF FORMING

GENERAL ELECTRIC COMPANY,...

1. A method of preparing a magnetic component, comprising:mechanically masking pre-selected sections of a surface portion of the component, using a nitrogen stop-off material to form a masked region in the component; and
heat-treating the component in a nitrogen-rich atmosphere at a temperature greater than about 900° C. to form intermixed first and second regions in the magnetic alloy, wherein
(a) the first region comprises a magnetic phase;
(b) the second region comprises a non-magnetic phase;
(c) a concentration of carbon in both the first and second regions is zero or less than about 0.05 weight %; and
(d) the second region comprises greater than about 0.1% of nitrogen.

US Pat. No. 10,190,205

METHOD AND APPARATUS FOR FLAME SPRAYING THERMOPLASTIC POWDERS

IBIX S.R.L., Santa Maria...

1. An apparatus for flame spraying thermoplastic powders, the apparatus comprising:a spray gun configured to perform spraying of thermoplastic powders and to be fed with a liquefied petroleum gas for producing a flame to be directed on an article to be coated in order to heat a surface of said article to a predetermined working temperature, said spray gun comprising a mixing device internally defining separated discharge chambers, said separated discharge chambers being configured to be fed with said thermoplastic powders to be sprayed with a transport inert gas, with a flow of compressed air and/or nitrogen and with said liquefied petroleum gas, and said spray gun comprising a mixing chamber communicating with said separated discharge chambers;
a flame ignition device for igniting said flame, connected to said spray gun and said flame ignition device comprising a spark ignition device, and a conductor element associated with said mixing device and said conductor element being connected to said spark ignition device so as to produce a spark at said mixing chamber;
a flame detection and monitor device configured to detect and monitor a presence of said flame;
an actuator means for interrupting or enabling a feed of the liquefied petroleum gas, said flame detection and monitor device being connected, directly or indirectly, with said actuator means, said spark ignition device comprising a piezoelectric spark ignition device fixed to said mixing device, said piezoelectric spark ignition device being provided with an activation means, said flame detection and monitor device comprises a temperature detection means associated with said mixing device;
a duct for feeding said liquefied petroleum gas in communication with one of said separated discharge chambers configured to be fed with said liquefied petroleum gas, said actuator means comprising a valve associated with said duct and said valve being housed in an external tubular element mounted on an end of said spray gun so as to intersect said duct, said valve being connected with said temperature detection means and said spark ignition device being mounted in a fixed manner on said external tubular element.

US Pat. No. 10,190,203

DEVICE FOR TREATING A METAL STRIP WITH A LIQUID COATING MATERIAL

Fontaine Engineering und ...

1. A device for treating a metal strip after the metal strip has exited a costing container filled with a liquid coating material, comprisinga blower, which is arranged above the coating container, with an air outlet gap for blowing excess parts of the liquid coating material off a vertically moving surface of the metal strip after passage of the metal strip through the coating container;
an electromagnetic stabilizer, which is arranged above the blower, for stabilizing the metal strip after leaving the coating container and the blower, wherein the electromagnetic stabilizer is so arranged above the blower that a spacing between a line of action of a maximum force of the electromagnetic stabilizer on the metal strip and the air outlet gap lies in a range of 100 to 1200 millimeters; and
a horizontal cross member mounted between and attached to two vertical posts,
wherein the blower is secured to and hangs below the horizontal cross member, and
wherein the electromagnetic stabilizer is arranged between the horizontal cross member and the blower, and
wherein the electromagnetic stabilizer and the blower are independently secured to the horizontal cross member, and
wherein the electromagnetic stabilizer hangs below the horizontal cross member.

US Pat. No. 10,190,202

METHOD AND DEVICE FOR COATING A METAL STRIP

FONTAINE ENGINEERING UND ...

1. A device for coating a metal strip with a coating material, comprising:a coating container with a correction roller, wherein the coating container is fillable with a liquid coating material, for conducting through the metal strip, and wherein the coating material adheres to the surface of the metal strip to be coated;
a blowing device, which is arranged downstream of the coating container in the transport direction of the metal strip, with a slot for conducting through the metal strip and for blowing excess parts of the still liquid coating material off the surface of the metal strip;
a curvature sensor for detecting the actual curvature of the metal strip after leaving the coating container;
a control device for adjusting the correction roller against the metal strip if the amount of the actual curvature exceeds a predetermined permissible curvature threshold value;
a regulating device for regulating the actual position of the metal strip to the predetermined target centre position in the slot of the blowing device by displacing the blowing device in a plane transverse to the transport direction of the metal strip with the help of a displacing device; and
a correction roller detection device for detecting the adjusted position of the correction roller or the change thereof;
wherein the displacement of the blowing device is carried out with consideration of the adjusted position of the correction roller.

US Pat. No. 10,190,199

METHOD OF ALLOYING REACTIVE COMPONENTS

Ormco Corporation, Orang...

1. A method of making a hyperelastic single-crystal CuAlNi shape memory alloy, the method comprising:forming a melt of CuAlNi by layering a layer of aluminum adjacent to a layer of copper and a layer of nickel, and-melting the layers together;
placing a seed of a desired composition for the shape memory alloy into the melt;
drawing the seed from the melt at a controlled rate so that a solid crystal is formed at a crystallization front; and
rapidly quenching the drawn crystal to produce a single crystal beta phase.

US Pat. No. 10,190,195

ALLOY POWDER FOR OVERLAY WELDING, AND WELD OVERLAY ALLOY MEMBER AND ENGINE VALVE OBTAINED USING THE SAME

TOYOTA JIDOSHA KABUSHIKI ...

1. An alloy powder for overlay welding, which is used for performing overlay welding on a surface of steel containing nitrogen, whereinthe alloy powder consists of 30% to 45% by mass of Mo, 10% to 20% by mass of Ni, 0.2% to 0.6% by mass of C, and greater than 1.0% to 2.0% by mass of Al, with the balance made up of incidental impurities and Co.

US Pat. No. 10,190,191

PRODUCING A TITANIUM PRODUCT

University of Utah Resear...

1. A method for producing a titanium product, comprising:obtaining TiO2-slag;
producing the titanium product from the TiO2-slag using a metallic reducing agent at a moderate temperature under a hydrogen atmosphere at a pressure to directly produce the titanium product chemically separated from metal impurities in the TiO2-slag, wherein the titanium product comprises TiH2 and optionally elemental titanium;
removing the metal impurities from the titanium product to form a purified titanium product; and
deoxygenating the titanium product at a higher temperature above the moderate temperature and under hydrogen atmosphere using a second reducing agent which is stronger than the metallic reducing agent to produce a particulate titanium product, coarsening the particulate titanium product to a target particle size range, and cooling the particulate titanium product under a hydrogen atmosphere.

US Pat. No. 10,190,188

MIXING METHOD AND DEVICE FOR SOLVENT EXTRACTION, ESPECIALLY IN HYDROMETALLURGICAL PROCESSES

TURBULENT TECHNOLOGIES LT...

1. A method of solute extraction, the method comprising:rotating an impeller so as to mix a first liquid and a second liquid in a reactor vessel said mixing at an average energy dissipation rate of at least 0.3 W/Kg and less than 20 W/Kg so that after the mixing an emulsion of the first and second liquids is present in the reactor vessel; said mixing of said first and second liquids continuing long enough to transfer at least some of said solute from said first liquid to said second liquid in said emulsion, wherein the mixing is performed so that:
i. a volume of said reactor having a local energy dissipation rate of between 2 to 20 W/Kg is at least 1%;
ii. a volume of said reactor having a local energy dissipation rate of greater than 20 W/kg is less than 0.01%; and
iii. said impeller has a blade width W a blade length L and a blade number k such that the product of said length squared and said width and said blade number is greater than 2.0% of the volume of said reactor.

US Pat. No. 10,190,187

MANUFACTURING METHOD FOR VERY HIGH-STRENGTH, COLD-ROLLED, DUAL-PHASE STEEL SHEETS

ARCELORMITTAL, Luxembour...

1. A manufacturing method for a cold-rolled and annealed Dual-Phase steel sheet, comprising the steps of:supplying a steel sheet having a composition comprising:
0.055%?C?0.095%;
2%?Mn?2.6%;
0.005%?Si?0.35%;
S?0.005%;
P?0.050
0.1?Al?0.3%;
0.05%?Mo?0.25%;
0.2%?Cr?0.5%;
Cr+2Mo?0.6%;
Ni?0.1%;
0.010?Nb?0.040%;
0.010?Ti?0.050%;
0.0005?B?0.0025% and
0.002%?N?0.007%,
a remainder of the composition comprising iron and the inevitable impurities resulting from smelting;
casting the steel sheet as a semi-finished product;
bringing the semi-finished product to a temperature TR in which 1150° C. ?TR?1250° C.;
hot-rolling the semi-finished product with an end-of-rolling temperature TFL ?Ar3 to obtain a hot-rolled product;
coiling the hot-rolled product at a temperature Tbob in which 500° C. ?Tbob ?570° C.;
descaling the hot-rolled product;
cold-rolling with a reduction from 30 to 80% to obtain a cold-rolled product;
heating the cold-rolled product at a rate 1° C./s?Vc ?5° C/s to an annealing temperature TM in which Ac1+40° C. ?TM ?Ac3-30° C. at which the product is held for a time 30s?tM?300s so as to obtain a heated and annealed product with a structure comprising austenite and a non-recrystallized ferrite fraction less than or equal to 15%;
cooling the product to a temperature less than a temperature Ms at a rate V high enough for all of the austenite to transform to martensite;
the steel sheet having a tensile strength between 980 and 1100 MPA and a microstructure consisting of 40 to 65% ferrite, 35 to 50% martensite and 0 to 10% bainite.

US Pat. No. 10,190,185

HARDENING METHOD OF ANNULAR WORKPIECE

JTEKT CORPORATION, Osaka...

1. A hardening method for an annular workpiece made of metal, comprising:a heating process that heats the annular workpiece to a hardening temperature;
an analyzing process that obtains a diameter of the annular workpiece heated to the hardening temperature, and divides the heated annular workpiece into at least a small diameter portion and a large diameter portion based on the obtained diameter; and
a cooling process that injects cooling liquid under an injection condition toward the annular workpiece that has been divided into at least the large diameter portion and the small diameter portion in the analyzing process such that a dimensional difference between the large diameter portion and the small diameter portion decreases, the injection condition for the large diameter portion being different from the injection condition for the small diameter portion, wherein
in the cooling process, the injection condition of the cooling liquid is adjusted by changing at least one of an injection quantity of the cooling liquid per unit time, an injection start timing of the cooling liquid, and an injection angle of the cooling liquid; and
the division of the large diameter portion and the small diameter portion is made through either process A or process B:
Process A:
determining a virtual center of the heated workpiece;
measuring each position in a circumferential direction of an outer periphery or an inner periphery of the heated workpiece;
obtaining a distance between the virtual center and each position in the circumferential direction of the outer periphery or the inner periphery of the workpiece;
converting the obtained distance into a coordinate data in a XY coordinates with the virtual center as an origin;
approximating the coordinate data by a method of least squares and calculating a circle which approximates an outer peripheral shape or an inner peripheral shape of the workpiece;
calculating a distance from a central coordinate of the approximate circle to each of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece as a radius of each of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece;
calculating a reference radius which divides the large diameter portion from the small diameter portion based on a first radius of a first virtual circle and a second radius of a second virtual circle, the first virtual circle being a circle which is centered around the central coordinate and in which a maximum value among the radii at the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece obtained is taken as a radius of the first virtual circle, the second virtual circle being a circle which is centered around the central coordinate and in which a minimum value among the radii at the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece obtained is taken as a radius of the second virtual circle;
calculating an average of the radius of the first virtual circle and the radius of the second virtual circle as a reference radius;
virtually dividing the work piece into a plurality of workpiece fragments such that central angles of the workpiece fragments in the circumferential direction of the first virtual circle or the second virtual circle are equal;
calculating an average value of the radii of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece for each of the workpiece fragments;
dividing a workpiece fragment of which the average value of the radii is greater than the reference radius as a large diameter portion and dividing a workpiece fragment of which the average value of the radii is smaller than or equal to the reference radius as a small diameter portion;
Process B:
determining a virtual center of the heated workpiece;
measuring each portion in a circumferential direction of an outer periphery or an inner periphery of the heated workpiece;
obtaining a distance between the virtual center and each position in the circumferential direction of the outer periphery or the inner periphery of the workpiece; converting the obtained distance into a coordinate data in a XY coordinates with the virtual center as an origin;
approximating the coordinate data by a method of least squares and calculating a circle which approximates an outer peripheral shape or an inner peripheral shape of the workpiece;
calculating a distance from a central coordinate of the approximate circle to each of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece as a radius of each of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece; virtually dividing the work piece into a plurality of workpiece fragments such that central angles of the workpiece fragments in the circumferential direction of the workpiece are equal;
calculating an average value of the radii of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece for each of the workpiece fragments;
dividing a workpiece fragment of which the average value of the radii is greater than a radius of the approximate circle as a large diameter portion and dividing a workpiece fragment of which the average value of the radii is smaller than or equal to the radius of the approximate circle as a small diameter portion.

US Pat. No. 10,190,165

HONEYCOMB TUBE

Cepheid, Sunnyvale, CA (...

1. A method comprising:providing a reaction tube, wherein the reaction tube comprises a planar frame defining a fluidic path including a well chamber comprising a plurality of wells between a first planar substrate and a second planar substrate, wherein the planar frame extends between a first end and a second end opposite the first end, a fluidic interface disposed along the first end of the reaction tube, the fluidic interface comprising a fluidic inlet and a fluidic outlet of the fluidic path;
introducing a liquid sample through the fluidic inlet of the fluidic interface of the reaction tube and advancing the liquid sample along the fluidic path via application of pressure to the fluidic inlet or the fluidic outlet of the fluidic interface;
filling a pre-amplification chamber of the fluidic path with the liquid sample by advancing the liquid sample along the fluidic path, the pre-amplification chamber being an enlarged portion of the fluidic path disposed along the fluidic path between the fluidic inlet and the well chamber so as to allow amplification of the liquid sample in the pre-amplification chamber before entering the well chamber and filling the plurality of wells;
filling the well chamber along the fluidic path with the liquid sample by further advancing the liquid sample along the fluidic path thereby depositing the fluid liquid sample within a plurality of wells of the well chamber; and
evacuating at least a portion of the liquid sample from the well chamber outside of the plurality of wells via application of pressure to the fluidic inlet or the fluidic outlet of the fluidic interface such that at least some of the liquid sample remains deposited within the plurality of wells.

US Pat. No. 10,190,161

APPARATUS AND METHOD FOR NUCLEIC ACID SEQUENCING BASED ON NANOWIRE DETECTORS

STMICROELECTRONICS S.R.L....

1. An apparatus for nucleic acid sequencing, comprising:a base-detection device in a detection site, the base-detection device being configured to detect bases of a portion of a nucleic acid strand at the detection site;
a conveying device configured to extend the nucleic acid strand and to cause the nucleic acid strand to slide through the detection site along a path; and
a structural layer having a first portion enclosing a first portion of the path, a second portion enclosing a second portion of the path, and an opening between the first portion and the second portion of the structural layer, the opening being aligned with the detection site;
wherein the base-detection device comprises a plurality of nanowire detectors arranged along the path, each nanowire detector of the plurality of nanowire detectors including a respective nanowire and one or more nucleic acid probes, which are fixed to the respective nanowire, each nucleic acid probe of the one or more nucleic acid probes fixed to the respective nanowire having the same sequence of nucleic acid bases.

US Pat. No. 10,190,159

METHODS AND SYSTEMS FOR NUCLEIC ACID SEQUENCING BY TUNNELING RECOGNITION

Roche Sequencing Solution...

1. A method of analyzing a nucleic acid molecule, the method comprising:attaching the nucleic acid molecule to a protein and a particle having a first diameter;
moving a portion of the nucleic acid molecule into an aperture defined by a first insulator, the aperture having a second diameter less than the first diameter, and the portion comprising a nucleotide;
applying a voltage across a first electrode and a second electrode;
contacting the portion of the nucleic acid molecule to both the first electrode and the second electrode within the aperture;
measuring a current through the first electrode, the portion of the nucleic acid molecule, and the second electrode; and
identifying the nucleotide of the portion of the nucleic acid molecule based on the current.

US Pat. No. 10,190,158

SYSTEMS AND METHODS FOR SELECTIVELY ADDRESSING SPARSELY ARRANGED ELECTRONIC MEASUREMENT DEVICES

Pacific Biosciences of Ca...

1. An integrated circuit comprising:a substrate;
a plurality of sectors arranged on the substrate, wherein each sector in the plurality of sectors comprises:
a programmable switch controller;
a counter bias line;
an amplifier input line;
a plurality of nano-electronic measurement devices spatially arranged on the substrate, wherein
each respective nano-electronic measurement device in the plurality of nano-electronic measurement devices includes a source that is coupled to the counter bias line and a drain that is coupled to the amplifier input line thereby obtaining an electrical signal on the drain of the respective nano-electronic measurement device,
the electrical signal is any one of a discrete set of electrical signals,
an identity of the electrical signal in the discrete set of electrical signals is determined by an electrical interaction between the corresponding nano-electronic measurement device and a particular charge label in a plurality of charge labels; and
a plurality of switches, wherein each switch in the plurality of switches gates the electrical signal between the drain of a corresponding nano-electronic measurement device in the plurality of nano-electronic measurement devices and the amplifier input line between
(i) an on state, in which the electrical signal at the drain of the corresponding nano-electronic measurement device is delivered to the amplifier input line, and
(ii) an off state, in which the electrical signal at the drain of the corresponding nano-electronic measurement device is not delivered to the amplifier input line, wherein
each respective switch in the plurality of switches is independently wired to the programmable switch controller thereby causing the respective switch to be in one of the on state and the off state responsive to the programmable switch controller.

US Pat. No. 10,190,157

MODIFIED NUCLEOTIDE LINKERS

Illumina Cambridge Limite...

1. A nucleoside or nucleotide covalently attached to a fluorophore through a linker, wherein said linker comprises a structure of formula (I) or (II), or combination of both:
wherein
R1 is optionally substituted C1-6 alkyl;
R2 is hydrogen or optionally substituted C1-6 alkyl;
R3 is optionally substituted C1-6 alkyl, —NR5—C(?O)R6, or —NR7—C(?O)—OR8;
R4 is hydrogen or optionally substituted C1-6 alkyl;
each R5 and R7 is independently hydrogen or optionally substituted C1-6 alkyl;
each R6 and R8 is independently optionally substituted C1-6 alkyl;
each of the methylene repeating unit in

 is optionally substituted;
X is methylene (CH2), oxygen (O), or sulfur (S);
m is an integer of 0 through 20;
n is an integer of 1 through 20; and
p is an integer of 1 through 20.

US Pat. No. 10,190,155

MOLECULAR TAG ATTACHMENT AND TRANSFER

NuGEN Technologies, Inc.,...

1. A method of determining a modification of a DNA sample, the method comprising:preparing a double-stranded DNA fragment linked with a plurality of oligonucleotide adaptors, the double-stranded DNA fragment comprising a nucleic acid sequence of interest;
denaturing the double-stranded DNA fragment, thereby generating a first strand DNA fragment and a second strand DNA fragment;
annealing a first probe to the first strand DNA fragment, the first probe comprising a probe oligonucleotide sequence complementary to and hybridizing to a first probe target region associated with the nucleic acid sequence of interest;
extending the first probe with a DNA polymerase using the first strand DNA fragment as a template, thereby generating a probe extension sequence;
annealing a primer or a second probe to the second strand DNA fragment, the primer and the second probe comprising a tag sequence;
generating an extension sequence using the primer or the second probe, the extension sequence including the tag sequence or a complement of the tag sequence; and
sequencing the extension sequence and the probe extension sequence, thereby determining the modification of the DNA sample based on existence or absence of the tag sequence or a complement of the tag sequence, wherein the annealing the primer or the second probe to the second strand DNA fragment and generating the extension sequence using the primer or the second probe comprises:
annealing the second probe to the second strand DNA fragment, the second probe comprising a non-extendable probe sequence and a tag sequence, the non-extendable probe sequence complementary to and hybridizing to a second probe target region associated with the nucleic acid sequence of interest;
annealing a primer sequence to a 3? end of the second strand DNA fragment;
extending the primer sequence with the DNA polymerase using the second strand DNA fragment as a template, thereby generating a primer extension sequence; and
ligating the primer extension sequence and the second probe, thereby generating the extension sequence comprising the tag sequence.

US Pat. No. 10,190,149

KIT AND METHOD FOR MEASURING THE ACTIVITY OF DEOXYNUCLEOSIDE KINASE

Biovica International AB,...

1. A kit comprising: (i) a DNA dependent DNA polymerase, (ii) at least one natural deoxynucleoside, and (iii) a detection system comprising a DNA template molecule, a DNA primer molecule, and a fluorescent moiety capable of being displaced from, or bound to, dsDNA synthesized by said DNA dependent DNA polymerase.

US Pat. No. 10,190,147

FAST DETECTION OF THE PRESENCE OF A TARGET MICROBE IN A LIQUID SAMPLE

ELEMENTAL SCIENTIFIC, INC...

1. A method comprising:holding a plurality of liquid samples prepared by adding an indicator configured to produce a characteristic change in light from the plurality of liquid samples when a target microbe metabolizes the indicator while the plurality of liquid samples is incubated, the plurality of liquid samples being held in a tray including a plurality of compartments partitioned one from another;
automatically sensing light from each of the plurality of liquid samples while the plurality of liquid samples is incubated; and
detecting the characteristic change in light from each of the plurality of liquid samples based on the sensed light from each of the plurality of liquid samples;
detecting a number of occurrences of the characteristic change in light from the plurality of liquid samples as the plurality of liquid samples is incubated;
determining whether the detected number of occurrences of the characteristic change in light exceeds a threshold number of occurrences of the characteristic change in light, the threshold number of occurrences of the characteristic change in light corresponding to a concentration of the target microbe within the liquid samples indicative of the presence of the target microbe; and
providing an indication that a presence of the target microbe has been detected based upon the determination,
wherein at an intermediate time interval prior to the end of the incubation period, the threshold number of occurrences of the characteristic change in light is a first threshold number associated with the intermediate time interval and the concentration of the target microbe is indicated by a number of occurrences of the characteristic change in light from a predetermined number of the plurality of liquid samples that exceeds the first threshold number,
wherein at the end of the incubation period, the threshold number of occurrences of the characteristic change in light is a second threshold associated with the entire incubation period and the concentration of the target microbe is indicated by a number of occurrences of the characteristic change in light from the plurality of liquid samples that exceeds the second threshold number.

US Pat. No. 10,190,146

METHOD OF CORRECTING FOR OXYGEN EFFECT

Ascensia Diabetes Care Ho...

1. A method for correcting the oxygen effect in determining the concentration of glucose in a fluid using an electrochemical test sensor, the method comprising the acts of:providing a test sensor, the test sensor comprising first and second working electrodes, and a counter electrode, the first working electrode including glucose oxidase, an oxidized form of a mediator and peroxidase, the second working electrode including glucose oxidase and the oxidized form of the mediator;
contacting the fluid with the test sensor;
measuring a first current from the first working electrode from a reduced form of the mediator;
measuring a second current from the second working electrode from the reduced form of the mediator; and
determining the concentration of glucose and correcting for the oxygen effect by using the first current measurement and the second current measurement.

US Pat. No. 10,190,114

LOW RESOURCE SAMPLE PROCESSOR CONTAINING HEAT-ACTIVATED SURFACE TENSION VALVES

VANDERBILT UNIVERSITY, N...

1. A method of processing a fluid sample comprising an analyte, the method comprising the steps of:(a) providing a device comprising a plurality of sequential chambers connected by tubing, each of said sequential chambers comprising a fluid and separated by plug material that is solid at temperatures below about 45° C., wherein a first reaction chamber of the plurality of sequential chambers comprises a magnetic or paramagnetic particle having a reactant on its surface;
(b) introducing into said first reaction chamber the fluid sample comprising the analyte;
(c) incubating said first reaction chamber under conditions sufficient to permit binding of said reactant with said analyte in said sample;
(d) heating said plug material in said device to a temperature above 45° C., thereby rendering at least a portion of said plug material into a liquid state, thereby forming a surface tension valve, wherein heating is performed by placing a heated magnet in proximity of said plug material;
(e) transporting said magnetic or paramagnetic particle from said first reaction chamber, into at least a second chamber of said plurality of sequential chambers through tubing disposed therebetween, wherein transporting comprises passing said magnet along said tubing to effect movement of said magnetic or paramagnetic particle; and
(f) detecting interaction of said analyte with said reactant by determining the presence or absence of said analyte in said second or a subsequent chamber of said plurality of said sequential chambers.

US Pat. No. 10,190,107

MODIFIED ?-GALACTOSIDASE

Amano Enzyme Inc., Nagoy...

1. A ?-galactosidase comprising an amino acid sequence which is different from a reference ?-galactosidase amino acid sequence in that one or more amino acids selected from the group consisting of the following (1) to (3) is/are proline, wherein the reference ?-galactosidase amino acid sequence shows a 90% or more identity to the amino acid sequence of SEQ ID NO: 4:(1) an amino acid corresponding to lysine at position 166 of the amino acid sequence of SEQ ID NO: 4;
(2) an amino acid corresponding to glycine at position 307 of the amino acid sequence of SEQ ID NO: 4; and
(3) an amino acid corresponding to alanine at position 833 of the amino acid sequence of SEQ ID NO: 4.

US Pat. No. 10,190,101

PRODUCTION OF LACTIC ACID FROM ORGANIC WASTE OR BIOGAS OR METHANE USING RECOMBINANT METHANOTROPHIC BACTERIA

STRING BIO PRIVATE LIMITE...

1. A recombinant methanotrophic bacterium capable of producing lactic acid from organic waste or biogas or methane, comprisinga heterologous nucleic acid or gene encoding for lactate dehydrogenase (ldh) enzyme, having the sequence of SEQ ID NO: 1, 3, or 5, or a combination thereof.

US Pat. No. 10,190,089

MODULAR SYSTEM AND METHOD FOR DETECTING MICROORGANISMS

3M Innovative Properties ...

1. A method for detecting a microorganism, the method comprising(i) inserting a culture device into a modular system, the modular system comprising a plurality of freestanding modules, the plurality of freestanding modules including:
a freestanding first module configured to hold a stomacher bag comprising a liquid sample;
a freestanding second module configured to transfer the liquid sample to the culture device; and
a freestanding third module comprising a housing and a detector, wherein a first slot, a second slot, and a third slot are formed in the housing of the freestanding third module, the freestanding third module configured to receive the culture device through the first slot;
interlocking features to align two or more freestanding modules of the plurality of freestanding modules; and
a data processor, wherein the data processor is programmed to:
receive at least one user-established preset criterion that defines a quantity of microorganism colonies;
receive colony count information from the detector;
compare the colony count information to the at least one preset criterion to determine whether one or more conditions exist in the culture device;
configure the freestanding third module to eject the culture device through the second slot when the one or more conditions exist in the culture device; and
configure the freestanding third module to eject the culture device through the third slot when the one or more conditions do not exist in the culture device;
(ii) analyzing the culture device for colony count information with the detector; and
(iii) provide the colony count information from the detector to the data processor.

US Pat. No. 10,190,088

ORGANISM CULTURING SYSTEM AND ORGANISM CULTURING METHOD

Hitachi, Ltd., Tokyo (JP...

12. A method for culturing an organism, comprising:storing a light-absorbing solution that absorbs more light in a second wavelength range than light in a first wavelength range in a liquid storage vessel, wherein the second wavelength range is at a shorter wavelength side than the first wavelength range,
storing a culture solution containing a photosynthetic organism to be cultured in a culture vessel,
disposing the culture vessel in the liquid storage vessel,
measuring the quantity of light that the culture vessel receives separately for different wavelength ranges using a first measuring unit,
measuring the quantity of external light surrounding the liquid storage vessel using a second light quantity measuring unit, and
controlling the liquid depth from the surface of the light-absorbing solution to the culture vessel in the liquid storage vessel based on the quantity of external light surrounding the liquid storage vessel and on the quantity of light measured for different wavelength ranges on the surface of the culture vessel,
wherein light intensity is decreased while the proportion of light in the first wavelength range and the second wavelength range is maintained, by controlling the liquid depth.

US Pat. No. 10,190,087

SINGLE USE CONTROLLED ENVIRONMENT MODULE

GE HEALTHCARE BIO-SCIENCE...

1. A single use, controlled environment manufacturing module comprising:a sealed bag formed of a substantially flexible material, the sealed bag having sterile interior and an exterior and capable of being inflated with air or gas, such that an environment within the sealed bag is sterile and is segregated from an ambient environment outside of the sealed bag;
at least one external connector, the at least one external connector comprising at least one of an aseptic connector and a tubing connector that extend from the exterior of the sealed bag to the interior of the sealed bag;
at least one set of access ports configured to provide hand-access to the interior of the sealed bag; and
a central controller operative to control and monitor the environment within the sealed bag and a manufacturing process conducted within the sealed bag;
wherein a sterile environment is achieved and maintained within the bag without clean-in-place or sterilization-in-place operations.

US Pat. No. 10,190,085

MICRO-INCUBATION SYSTEMS FOR MICROFLUIDIC CELL CULTURE AND METHODS

EMD Millipore Corporation...

1. A method of culturing cells, comprising:disposing cells into a culture chamber, the culture chamber connected to a plurality of microfluidic channels, the culture chamber and microfluidic channels configured into a culture unit on a well plate;
interfacing the well plate with a microincubator manifold, the microincubator manifold having a gasket for providing a removable air-tight seal to the well plate, and a heat exchange module, wherein the manifold seals to the well plate, thereby enclosing an incubation volume of gas, wherein the heat exchange module provides a controlled temperature above and in communication with the culture chamber; and
observing and/or assaying the cells in the culture chamber, wherein the microincubator manifold comprises a transparent window in a region disposed above the culture chamber.

US Pat. No. 10,190,082

MULTIWELL PLATE

Seng Enterprises Ltd., L...

1. A multiwell plate comprising:a unitary structure including a plurality of wells and a plurality of picowells at the bottoms of the wells, wherein the picowells are formed of a transparent hydrogel and are transparent;
a transparent gel covering the plurality of hydrogel-formed picowells.

US Pat. No. 10,190,081

VOLATILE ORGANIC COMPOUND RECOVERY SYSTEM AND METHOD

EcoPAS LLC, Irvine, CA (...

1. A method of making a fermented beverage, comprising, during fermentation of a must in a fermentation vessel:feeding vapors from a head space of the fermentation vessel to a condenser having a first condenser module and a second condenser module;
controlling an inlet of the second condenser module to open or close based on a flow rate of the vapors from the head space of the fermentation vessel;
condensing a portion of the vapors in the condenser to thereby produce a mixed-phase stream comprising CO2 and an alcohol-containing condensate;
feeding the mixed-phase stream to a collection tank;
sequestering the condensate from the mixed-phase stream through a first port of the collection tank; and
removing CO2 from the mixed-phase stream through a second port of the collection tank.

US Pat. No. 10,190,080

METHOD FOR CLEANING SYSTEMS

Thonhauser GmbH, Giesshe...

1. A method for cleaning a system and detecting a state of cleanliness of the system by monitoring a color change and comparing the color change to a setpoint value, the method comprising the following steps:a) providing a cleaning composition comprising at least one oxidizing agent for oxidizing impurities and containing a color indicator;
b) continuously conducting the cleaning composition through the system;
c) determining color values F of the cleaning composition at fixed time intervals and at one or more locations including at least after exit of the cleaning composition from the system;
d) calculating differences ?F between color values obtained from two consecutive determinations;
e) before putting a clean system into operation, determining color values until a difference ?F=0 is determined, whereafter the color value measured last is defined as an inherent system value FA and a maximum tolerable deviation from this value is specified as a setpoint value ?FA for cleaning; and
f) cleaning the system after its operation is carried out until the difference ?FA between two consecutive color values FR is equal to or smaller than ?FA, which shows that the system is clean.

US Pat. No. 10,190,079

COMPOSITIONS CONTAINING ONE OR MORE POLY ALPHA-1,3-GLUCAN ETHER COMPOUNDS

E I DU PONT DE NEMOURS AN...

1. A composition comprising a cellulase and a poly alpha-1,3-glucan compound comprising the structure:
wherein
(i) n is at least 6,
(ii) each R is independently H or a positively charged organic group, wherein at least one R group is a positively charged organic group,
(iii) the poly alpha-1,3-glucan compound has a degree of substitution of about 0.05 to about 3.0 with the positively charged organic group, and
(iv) at least 90% of the glycosidic linkages of the poly alpha-1,3-glucan compound are alpha-1,3 glycosidic linkages.

US Pat. No. 10,190,078

DETERGENT

1. An automatic dishwashing detergent composition comprising:a) from about 0.1% to about 20% by weight of a cleaning surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, an amphoteric surfactant, and mixtures thereof;
b) from about 0.1% to about 20% by weight of a cleaning amine,wherein the amine is a polyetheramine selected from the group consisting of polyetheramines of Formula (I), Formula (II), Formula (III) and a mixture thereof:
wherein each of R1-R12 is independently selected from H, alkyl, cycloalkyl, aryl, alkylaryl, or arylalkyl, wherein at least one of R1-R6 and at least one of R7-R12 is different from H, each of A1-A9 is independently selected from linear or branched alkylenes having about 2 to about 18 carbon atoms, each of Z1-Z4 is independently selected from OH or NH2, wherein at least one of Z1-Z2 and at least one of Z3—Z4 is NH2, wherein the sum of x+y is in the range of about 2 to about 200, wherein x?1 and y?1, and the sum of x1+y1 is in the range of about 2 to about 200, wherein x1?1 and y1?1

wherein R is selected from H or a C1-C6 alkyl group, each of k1, k2, and k3 is independently selected from 0, 1, 2, 3, 4, 5, or 6, each of A1, A2, A3, A4, A5, and A6 is independently selected from a linear or branched alkylene group having from about 2 to about 18 carbon atoms or mixtures thereof, x?1, y?1, and z?1, and the sum of x+y+z is in the range of from about 3 to about 100, each of Z1, Z2, and Z3 is independently selected from NH2 or OH, where at least two of Z1, Z2, and Z3 are NH2; and the polyetheramine has a weight average molecular weight of from about 150 to about 1000 grams/mole.

US Pat. No. 10,190,076

METHODS FOR PRODUCING A HIGH PROTEIN CORN MEAL FROM A WHOLE STILLAGE BYPRODUCT AND SYSTEM THEREFORE

Fluid Quip, Inc., Spring...

1. A method for recovering oil from a whole stillage byproduct produced via a corn dry-milling process, the method comprising:in a corn dry-milling process for making alcohol, separating the whole stillage byproduct into an insoluble solids portion and a thin stillage portion, which includes free oil and protein;
prior to any evaporation step, separating out a lighter water soluble solids portion, which includes the oil, from heavier constituents, including the protein, in the thin stillage portion, via weights, wherein the heavier constituents, including the protein, are not subsequently subjected to any evaporator; and
separating the oil from the water soluble solids portion to provide an oil portion after subjecting the separated water soluble solids portion to evaporation via an evaporator.

US Pat. No. 10,190,075

ENRICHMENT OF PALMITOLEIC ACID AND PALMITOLEIC ACID DERIVATIVES BY DRY AND SOLVENT-AIDED WINTERIZATION

OMEGA PROTEIN CORPORATION...

1. A method for producing an oil composition of a liquid olein fraction that is not derived from algae, wherein the oil composition comprises a mixture of not more than 0.2% (wt %) palmitic acid and at least 59% (wt %) palmitoleic acid from said liquid olein fraction, said method comprising fractional crystallization of a starting oil mixture containing more than 0.2% (wt %) palmitic acid and less than 59% (wt %) palmitoleic acid to produce the liquid olein fraction and a solid stearin fraction, and wherein said fractional crystallization comprises:(a) incubating a solution of said starting oil mixture in an organic solvent at a ratio of organic solvent to starting oil mixture at a temperature between about ?20° C. to about ?70° C. to produce said solid stearin fraction and said liquid olein fraction, wherein said organic solvent is selected from methanol, ethanol, isopropyl alcohol, acetone, and hexane, and wherein the ratio of methanol to the starting oil mixture is 2:1 to 1:1, the ratio of ethanol to the starting oil mixture is 2:1 to 1:1, the ratio of isopropyl alcohol to the starting oil mixture is 1:4 to 1:6, and the ratio of acetone to the starting oil mixture is 1:6 to 1:8, or the ratio of hexane to the starting oil mixture is 1:8 to 1:10;
(b) separating said solid stearin fraction and said liquid olein fraction; and
(c) collecting said liquid olein fraction to produce the oil composition of said liquid olein fraction.

US Pat. No. 10,190,073

LIPID COMPRISING LONG CHAIN POLYUNSATURATED FATTY ACIDS

COMMONWEALTH SCIENTIFIC A...

1. A process for producing extracted plant lipid, comprising the steps of:i) obtaining a Brassica sp. seed comprising extractable lipid having a total fatty acid content comprising fatty acids in an esterified form, the fatty acids comprising oleic acid, palmitic acid, ?6 fatty acids which comprise linoleic acid (LA), ?3 fatty acids which comprise ?-linolenic acid (ALA), stearidonic acid (SDA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), and optionally one or more of eicosapentaenoic acid (EPA) and eicosatetraenoic acid (ETA), wherein (a) the level of palmitic acid in the total fatty acid content of the extractable lipid is between about 2% and 16%, (b) the level of myristic acid (C14:0) in the total fatty acid content of the extractable lipid is less than 1%, and (c) the level of DHA in the total fatty acid content of extractable lipid in the plant part is between 20.1% and 30%, and
ii) extracting lipid from the Brassica sp. seed to thereby produce extracted plant lipid.

US Pat. No. 10,190,069

LUBRICATING COMPOSITION CONTAINING A THIOCARBAMATE COMPOUND

The Lubrizol Corporation,...

1. A lubricating composition comprising an oil of lubricating viscosity and 0.01 wt % to 5 wt % of an ashless sulfur containing compound comprising a thiocarbamate compound having an optionally-substituted hydrocarbyl group on an S-atom and an optionally-substituted hydrocarbyl group on an N-atom,wherein the ashless thiocarbamate compound having an optionally-substituted hydrocarbyl group on an S-atom and an optionally-substituted hydrocarbyl group on an N-atom is represented by the formula (4):
whereinY is S;R2 is a hydrocarbyl group consisting of 6 to 20 carbon atoms;R3 is a hydrocarbylene group; andR4 is a hydrocarbyl group consisting of 6 to 20 carbon atoms.

US Pat. No. 10,190,068

GIANT ELECTRORHEOLOGICAL FLUID SURFACTANT ADDITIVES

THE HONG KONG UNIVERSITY ...

1. A method for preparing giant electrorheological (GER) fluids, comprising the steps of:grinding a nanoparticle composite comprising urea and 0.2-5.0 wt % sodium dodecylbenzenesulfate (SDBS);
agitating the ground composite via ultrasonification for at least 30 minutes at 20-40° C.;
drying the composite for at least 12 hours in a freeze drying machine; and
suspending the composite in a non-conducting oil.

US Pat. No. 10,190,067

HIGH PERFORMANCE ENVIRONMENTALLY ACCEPTABLE HYDRAULIC FLUID

Washington State Universi...

1. A hydraulic fluid, comprising:one or more of a hydraulic environmental ester synthetic (HEES) and a hydraulic environmental triglyceride (HETG) at 10% to 85% by weight of the hydraulic fluid, wherein the one or more of HEES and HETG are or include natural and/or synthetic esters of at least one of vegetable-based and animal-based oils which are oleates;
a polyalphaolefin (PAO) at 1% to 40% by weight of the hydraulic fluid;
a polyalkylene glycol (PAG) at 1% to 40% by weight of the hydraulic fluid, wherein a ratio of PAO/PAG ranges from 0.2 to 5.

US Pat. No. 10,190,066

METHOD AND SYSTEM FOR BIOMASS HYDROGASIFICATION

G4 Insights Inc., Burnab...

1. A method, comprising:pyrolyzing biomass to produce a pyrolysis gas and char;
hydrogasifying the pyrolysis gas in the presence of a catalyst and hydrogen produced by a hydrogen generator powered by a renewable energy source, to produce a gas mixture;
separating the gas mixture into a substitute natural gas stream and a residual gas stream.

US Pat. No. 10,190,065

FEED DELIVERY SYSTEM AND METHOD FOR GASIFIER

1. A system for processing material for a gasifier, said system comprising:a first auger feeder adapted to receive and process material to be gasified;
an inclined conveyor adapted to receive said material processed by said first auger feeder, said conveyor adapted to transfer said material;
a second auger feeder positioned above said first auger feeder and adapted to receive said material transferred by said conveyor, said second auger feeder adapted to feed said material;
a tube connected to said second auger feeder such that said tube is adapted to receive said material from said second auger feeder, said tube comprising:
i) a body connected to said second auger feeder, said body having an inner wall that defines an opening adapted to receive said material from said second auger feeder such that said body is adapted to allow a flow of said material through said opening and out of said tube to said gasifier; and
ii) at least one restrictor that extends inwardly from said inner wall of said body into said opening, said at least one restrictor adapted to extend into said flow of said material to impede said flow, said at least one restrictor configured to enable said flow to flow around said at least one restrictor to exit out of said tube, wherein each said restrictor is adjustable such that a respective position of each said restrictor is adapted to be adjusted relative to said inner wall; and
a gasifier connected to said tube such that said gasifier is adapted to receive said material from said tube.

US Pat. No. 10,190,063

PRODUCTION OF OILFIELD HYDROCARBONS

Sasol Technology Propriet...

1. A process to produce olefinic products in the carbon range C16-C30 suitable for use as or conversion to oilfield hydrocarbons, the process comprising:separating an olefins-containing Fischer-Tropsch condensate into a light fraction which is a C5-C7 fraction, an intermediate fraction which is a C8-C15 fraction which includes paraffins and alpha-olefins and a heavy fraction which is a C16-C22 fraction which includes paraffins and alpha-olefins;
oligomerising at least a portion of the light fraction using a zeolitic catalyst to produce a first olefinic product which includes branched internal olefins;
carrying out either one or both of the steps of:
(i) dehydrogenating at least a portion of the intermediate fraction to convert the paraffins to internal olefins thereby to produce an intermediate product which includes internal olefins and alpha-olefins, and synthesising higher olefins, by means of dimerisation or olefin metathesis, from the intermediate product which includes internal olefins and alpha-olefins to produce a second olefinic product; and
(ii) dimerising at least a portion of the intermediate fraction to produce a second olefinic product; and
dehydrogenating at least a portion of the heavy fraction to convert the paraffins to internal olefins thereby to produce a third olefinic product which includes internal olefins,
the first olefinic product and the second olefinic product being such that a combination of the first olefinic product and the second olefinic product provides an olefinic product with at least 50% by mass of hydrocarbons having carbon chain lengths of between 15 and 30 carbon atoms per molecule.

US Pat. No. 10,190,060

PROCESS FOR INCREASING PROCESS FURNACES ENERGY EFFICIENCY

SAUDI BASIC INDUSTRIES CO...

1. A process for increasing process furnaces energy efficiency through gas turbine integration by using turbine exhaust gas, wherein a hydrocarbon feed is heated in a furnace, said process comprising the following steps:i) feeding furnace combustion air to burners of said furnace together with furnace fuel to provide high temperature heat to said furnace;
ii) cooling the hydrocarbon feed thus processed by using water from a steam drum under the formation of water vapour from some of the water;
iii) returning the mixture of water and water vapour thus formed to said steam drum;
iv) withdrawing saturated high-pressure steam from said steam drum and feeding said saturated high-pressure steam to a heat recovery unit; and
v) feeding said turbine exhaust gas to said heat recovery unit for converting said high-pressure steam into super heated high pressure steam, thereby decoupling the gas turbine from the process furnace.

US Pat. No. 10,190,059

PROCESS FOR THE HYDROTREATMENT OF RENEWABLE MATERIALS, WITH AN OPTIMIZED GAS RECYCLE

IFP Energies Nouvelles, ...

1. A process for the hydrotreatment of a feed obtained from renewable sources to produce paraffinic hydrocarbons which is carried out in the presence of hydrogen in a fixed bed reactor having a plurality of catalytic zones disposed in series and each catalytic zone comprising at least one hydrotreatment catalyst, said process comprising:a) dividing a liquid feed stream F into a plurality of different part-streams of liquid feed, F1 to Fn, respectively, wherein the number of part-streams of liquid feed is equal to the number of catalytic zones n in said fixed bed reactor, Z1 to Zn, respectively, and n is a whole number in the range of 2 to 10;
b) injecting a first part-stream of liquid feed F1 into a first catalytic zone Z1, and injecting a second part-stream of liquid feed F2 into a second catalytic zone Z2 and so on if n is greater than 2;
c) hydrotreating each part-stream, F1 to Fn, in each catalytic zone, Z1 to Zn, respectively, in the presence of hydrogen at a temperature in the range of 180° C. to 400° C., at a pressure in the range of 0.1 MPa to 15 MPa, at an hourly space velocity in the range of 0.1 h?1 to 10 h?1, and with a ratio of flow rate of hydrogen to flow rate of liquid feed in the range of 150 to 1500 Nm3/m3 to produce at least one effluent containing paraffinic hydrocarbons discharged from said reactor, wherein the mass flow rate of hydrogen sent to the first catalytic zone Z1 represents more than 80% by weight of the total mass flow rate of hydrogen used in the hydrotreatment process, hydrotreated product and hydrogen-containing gas are discharged from each catalytic zone, and, except for the nth catalytic zone, the hydrotreated product and hydrogen-containing gas from each catalytic zone are introduced into the next catalytic zone in the series, and the hydrotreated product and hydrogen-containing gas from the nth catalytic zone form said at least one effluent discharged from said reactor;
d) separating said effluent from c) in at least one separation step in order to separate at least one gaseous fraction containing hydrogen and at least one liquid fraction containing paraffinic hydrocarbons;
e) dividing at least a portion of said at least one liquid fraction containing paraffinic hydrocarbons from d) into a plurality of liquid recycle streams, RL1 to RLn, and recycling a first liquid recycle stream RL1 to the first catalytic zone Z1, and recycling a second liquid recycle stream RL2 to the second catalytic zone Z2 and so on if n is greater than 2; and
f) optionally dividing at least a portion of said gaseous fraction containing hydrogen from d) into a plurality of gaseous recycle streams, RG1 to RGn, and optionally recycling a first gaseous recycle stream RG1 to the first catalytic zone Z1, and optionally recycling a second gaseous recycle stream RG2 to the second catalytic zone Z2 and so on if n is greater than 2;
wherein each of the catalytic zones has a local recycle ratio which is defined as the weight ratio between (i) the total weight of the liquid recycle stream introduced to the catalytic zone plus any the liquid recycle streams introduced into any previous catalytic zone in the series, if present, and (ii) the part-stream of liquid feed introduced into the catalytic zone, and wherein said local recycle ratio of each catalytic zone is >0 to 2;
wherein the first catalytic zone of the series receives a liquid diluting stream and optionally a gaseous diluting stream, wherein the optional gaseous diluting stream is the first gaseous recycle stream from f);
wherein each of the other catalytic zones, Z2 to Zn, in the series receives liquid and gaseous diluting streams, wherein said liquid diluting streams are: (1) the part-stream(s) of liquid feed streams introduced into each of the previous catalytic zones in the series, if present, (2) the liquid recycle streams from e) introduced into each of the previous catalytic zones in the series, if present, and (3) the liquid recycle stream from e) introduced into the catalytic zone, and said gaseous diluting streams are: (4) the hydrogen-containing gas discharged from the previous catalytic zone in the series, if present, (5) the optional gaseous recycle streams from f) introduced into each of the previous catalytic zones in the series, if present, and (6) the optional gaseous recycle stream from f) introduced into the catalytic zone; and
wherein each of the catalytic zones has a local dilution ratio defined as the weight ratio between (I) the total quantity of liquid and gaseous diluting streams introduced into the catalytic zone and (II) the part-stream of liquid feed introduced into the catalytic zone, and wherein said local dilution ratio of each catalytic zone is >0 to less than 4.

US Pat. No. 10,190,057

FISCHER-TROPSCH SYNTHESIS

SASOL TECHNOLOGY PROPRIET...

1. A method of synthesising Fischer-Tropsch products, the method includingfeeding a synthesis gas to a moving-bed Fischer-Tropsch synthesis reactor containing a Fischer-Tropsch catalyst in a moving catalyst bed, catalytically converting at least a portion of the synthesis gas in the moving catalyst bed to Fischer-Tropsch products and withdrawing the Fischer-Tropsch products from the moving-bed Fischer-Tropsch synthesis reactor,
the method further including, while the moving-bed Fisher-Tropsch synthesis reactor is on-line:
withdrawing a portion of the Fischer-Tropsch catalyst from the moving-bed Fischer-Tropsch synthesis reactor;
discarding from about 15 wt % to about 60 wt % of the withdrawn Fischer-Tropsch catalyst;
adding a reactivated Fischer-Tropsch catalyst to the moving-bed Fischer-Tropsch synthesis reactor; and
adding a fresh Fischer-Tropsch catalyst, in addition to the reactivated catalyst, to the moving-bed Fischer-Tropsch synthesis reactor.

US Pat. No. 10,190,056

CONVERSION OF SOLID BIOMASS INTO A LIQUID HYDROCARBON MATERIAL

SHELL OIL COMPANY, Houst...

1. A process for producing liquid hydrocarbon products from a solid biomass feedstock comprising:a) providing in a hydropyrolysis reactor vessel a hydropyrolysis catalyst composition that comprises one or more active metals selected from cobalt, molybdenum, nickel, tungsten, ruthenium, platinum, palladium, iridium and iron on an oxide support, wherein the active metals are present in a partially sulfided form to the extent that the hydropyrolysis catalyst composition contains sulfur in an amount of from 10 to 90% of a full stoichiometric amount;
b) contacting the solid biomass feedstock with the hydropyrolysis catalyst composition and molecular hydrogen in the hydropyrolysis reactor vessel at a temperature in the range of from 350 to 600° C. and a pressure in the range of from 0.50 to 7.50 MPa, to produce a product stream comprising partially deoxygenated hydropyrolysis product, H2O, H2, CO2, CO, C1-C3 gases, char and catalyst fines;
c) removing the char and catalyst fines from the product stream;
d) hydroconverting the partially deoxygenated hydropyrolysis product in a hydroconversion reactor vessel in the presence of one or more hydroconversion catalyst and of the H2O, CO2, CO, H2, and C1-C3 gas generated in step a), to produce a vapour phase product comprising substantially fully deoxygenated hydrocarbon product, H2O, CO, CO2, hydrogen and C1-C3 gases.

US Pat. No. 10,190,054

SYSTEM AND PROCESS FOR CONVERTING WHOLE TIRES AND OTHER SOLID CARBON MATERIALS INTO RECLAIMABLE AND REUSEABLE COMPONENTS

1. A method of converting carbon based material comprising the steps of:providing a rotatable chamber in which the material can be heated;
introducing the material into the chamber;
indirectly heating the chamber;
rotating the heated chamber with the material in the heated chamber to reduce the material;
collecting gases or oil or both from the reduced material from the chamber; and
collecting residual solids from the reduced material from the chamber;
wherein the chamber is heated to a temperature between about 350° F. and about 1100° F.;
wherein the carbon based material is rubber belting, a rubber construction track, a tire in the range of 4 inches in diameter to 120 inches in diameter, or a combination thereof, and wherein the material is introduced into the chamber without shredding, cutting or comminuting the material.

US Pat. No. 10,190,049

MESOGENIC MEDIA AND LIQUID CRYSTAL DISPLAY

MERCK PATENT GMBH, Darms...

1. Medium comprising one or more bimesogenic compounds, one or more nematogenic compound, one or more chiral compound and one or more compounds of formula I,R11-A11-(Z12-A12)m-AG  I
in which,
A11 and A12 each, independently of one another, denote an aryl-, heteroaryl-, heterocyclic- or alicyclic group optionally being substituted by one or more identical or different groups L,
L in each case, independently of one another, denotes, halogen, —CN, —NO2, —NCO, —NCS, —OCN, —SCN, straight-chain or branched alkyl or alkoxy having 1 to 5 C atoms, where, in addition, one or more non-terminal CH2 groups in these radicals may each be replaced, independently of one another, by —C?C—, —CF2O—, —CH?CH—,
—O—, —CO—O—, —O—CO— in such a way that O atoms are not linked directly to one another, and in which, in addition, one or more H atoms may be replaced by halogen,Z12 in each case, independently of one another, denotes
—O—, —S—, —CO—, —COO—, —OCO—, —S—CO—, —CO—S—, —O—COO—, —CO—NR0—, —NR0-CO—, —NR0-CO—NR00, —NR0-CO—O—,
—O—CO—NR0—, —OCH2—, —CH2O—, —SCH2—, —CH2S—, —CF2O—, —OCF2—, —CF2S—, —SCF2—, —CH2CH2—, —(CH2)4—, —CF2CH2—, —CH2CF2—, —CF2CF2—, —CH?N—, —N?CH—, —N?N—,
—CH?CR0—, —CY01?CY02—, —C?C—, —CH?CH—COO—,
—OCO—CH?CH—, or a single bond,
Y01 and Y02 each, independently of one another, denote H, F, Cl or CN,
R0 and R00 each, independently of one another, denote H or alkyl having 1 to 12 C atoms,
R11 denotes an alkyl or alkoxy radical having 1 to 15 C atoms, where, in addition, one or more non-terminal CH2 groups in these radicals may each be replaced, independently of one another, by —C?C—, —CF2O—, —CH?CH—,

 —O—, —CO—O—, —O—CO— in such a way that O atoms are not linked directly to one another, and in which, in addition, one or more H atoms may be replaced by halogen,
AG denotes -Sp-X11,
Sp denotes —(CH2)—,
p denotes 0, 1 or 2,
X11 denotes a group —NH2, —SH, —OH, —(CO)OH or a group of the formulae
andm denotes 0, 1 or 2;wherein:the one or more bimesogenic compound is selected from the group of compounds of formulae A-I to A-III,

wherein
R1 and R12,
R21 and R22,
and R31 and R32 are each independently H, F, Cl, CN, NCS or a straight-chain or branched alkyl group with 1 to 25 C atoms which may be unsubstituted, mono- or polysubstituted by halogen or CN, it being also possible for one or more non-adjacent CH2 groups to be replaced, in each occurrence independently from one another, by —O—, —S—, —NH—, —N(CH3)—, —CO—, —COO—, —OCO—, —O—CO—O—, —S—CO—, —CO—S—, —CH?CH—, —CH?CF—, —CF?CF— or —C?C— in such a manner that oxygen atoms are not linked directly to one another,
MG11 and MG12,
MG21 and MG22, and
MG31 and MG32 are each independently a mesogenic group,
Sp1, Sp2 and Sp3 are each independently a spacer group comprising 5 to 40 C atoms, wherein one or more non-adjacent CH2 groups, with the exception of the CH2 groups of Sp1 linked to O-MG11 and/or O-MG12, of Sp2 linked to MG21 and/or MG22 and of Sp3 linked to X31 and X32, may also be replaced by —O—, —S—, —NH—, —N(CH3)—, —CO—, —O—CO—,
—S—CO—, —O—COO—, —CO—S—, —CO—O—,
—CH(halogen)-, —CH(CN)—, —CH?CH— or —C?C—, in such a way that no two O-atoms are adjacent to one another, no two —CH?CH— groups are adjacent to each other, and no two groups selected from —O—CO—, —S—CO—, —O—COO—, —CO—S—, —CO—O— and —CH?CH— are adjacent to each other, and
X31 and X32 are independently from one another a linking group selected from —CO—O—, —O—CO—, —CH?CH—,
—C?C— or —S—, and, alternatively, one of them may also be either —O— or a single bond, and, again alternatively, one of them may be —O— and the other one a single bond;
the one or more nematogenic compound is selected from the group of compounds of formulae B-I to B-III,

wherein
RB1, RB21,
RB22, RB31 and
RB32 are each independently H, F, Cl, CN, NCS or a straight-chain or branched alkyl group with 1 to 25 C atoms which may be unsubstituted, mono- or polysubstituted by halogen or CN, it being also possible for one or more non-adjacent CH2 groups to be replaced, in each occurrence independently from one another, by —O—, —S—, —NH—, —N(CH3)—, —CO—,
—COO—, —OCO—, —O—CO—O—, —S—CO—, —CO—S—, —CH?CH—, —CH?CF—, —CF?CF— or —C?C— in such a manner that oxygen atoms are not linked directly to one another,
XB1 is F, Cl, CN, NCS,
ZB1, ZB2 and
ZB3 are in each occurrence independently —CH2—CH2—,
—CO—O—, —O—CO—, —CF2-O—, —O— CF2—, —CH?CH— or a single bond,
are in each occurrence independently
alternatively one or more of
areandn is 1, 2 or 3; and
the one or more chiral compound is selected from the group of compounds of formulae C-I to C-III,

the latter ones including the respective (S,S) enantiomers,
and wherein
E and F are each independently 1,4-phenylene or trans-1,4-cyclohexylene,
v is 0 or 1,
Z0 is —COO—, —OCO—, —CH2CH2— or a single bond, and
R is alkyl, alkoxy or alkanoyl with 1 to 12 C atoms.

US Pat. No. 10,190,048

LIQUID-CRYSTALLINE MEDIUM AND LIQUID-CRYSTAL DISPLAY COMPRISING THE SAME

Merck Patent GmbH, Darms...

1. A liquid-crystalline medium comprisinga) one or more compounds selected from the group of compounds of formulae I-1 and I-2

in which
R11 and R12 independently of each other denote H or alkyl with 1 to 5 C atoms, and
b) one or more compounds selected from the group of compounds of formulae II and III

in which
R21 denotes an unsubstituted alkyl radical having 1 to 7 C atoms, an unsubstituted alkenyl radical having 2 to 7 C atoms or an unsubstituted alkoxy radical having 1 to 6 C atoms,
R22 denotes an unsubstituted alkyl radical having 1 to 7 C atoms, an unsubstituted alkoxy radical having 1 to 6 C atoms or an unsubstituted alkenyloxy radical having 2 to 6 C atoms, and
l denotes 0 or 1,
R31 denotes an unsubstituted alkyl radical having 1 to 7 C atoms or an unsubstituted alkenyl radical having 2 to 7 C atoms,
R32 denotes an unsubstituted alkyl radical having 1 to 7 C atoms, an unsubstituted alkoxy radical having 1 to 6 C atoms or an unsubstituted alkenyloxy radical having 2 to 6 C atoms, and
denotes

US Pat. No. 10,190,043

COMPOSITIONS COMPRISING QUANTUM DOTS

Merck Patent GmbH, Darms...

1. An electroluminescent device comprising a light emitting layer consisting of one type of quantum dot and one type of organic emitter, wherein said organic emitter is a phosphorescent, non-conjugated polymeric compound that includes at least one unit comprising a host compound, and a metal complex, the metal selected from a transition, a rare earth, a lanthanide, or an actinide metal, and the concentration of the quantum dots in the composition is in a range from 0.1 to 20 wt %;wherein the quantum dot is selected from the group consisting of CdSe, CdS, CdTe, ZnSe, ZnS, ZnTe, alloys thereof, combinations thereof, core/shell structures thereof, and core multi-shell layered structures thereof, with a trioctylphosphine oxide coating the surface of the quantum dot;
wherein the one organic emitter is a phosphorescent, non-conjugated polymer that includes a repeat unit selected from formula (77) or (78)

 wherein X and Y are independently selected from H, F, an alkyl group with 1 to 40 carbon atoms, an alkenyl group with 2 to 40 carbon atoms, an alkynyl group with 2 to 40 carbon atoms, a substituted or unsubstituted aryl group with 6 to 40 carbon atoms, and a substituted or unsubstituted heteroaryl group, wherein the heteroaryl group has 5 to 25 ring members.

US Pat. No. 10,190,040

SELF-SUSPENDING PROPPANT FOR HYDRAULIC FRACTURING

STEP ENERGY SERVICES LTD....

1. A proppant composition comprising:a volume of water;
300-500 kg/m3 of a self-suspending proppant, including a plurality of proppant granules each with a hydrophilic polymer coating, the hydrophilic polymer coatings of the self-suspending proppant together defining a total polymer volume; and
100-800 kg/m3 of an untreated proppant,wherein there is a total proppant load including both the self-suspending proppant and the untreated proppant of 500-1000 kg/m3 in the composition and wherein a concentration of the self-suspending proppant in the water is sufficient (i) to reduce the water to an unabsorbed volume of less than 25% of the volume of water and (ii) to hydrate at least 75% of the total polymer volume.

US Pat. No. 10,190,038

METHOD OF USING SOPHOROLIPIDS IN WELL TREATMENT OPERATIONS

Baker Hughes, a GE Compan...

1. A method of enhancing recovery of a well treatment fluid from a well after subjecting the well to a well treatment operation with the well treatment fluid, the method comprising pumping into the well the well treatment fluid and then, after completion of the well treatment operation, recovering the well treatment fluid from the well, the well treatment fluid comprising at least one sophorolipidic compound selected from the group consisting of:

US Pat. No. 10,190,034

NON-REDUCING STABILIZATION COMPLEXANT FOR ACIDIZING COMPOSITIONS AND ASSOCIATED METHODS

Halliburton Energy Servic...

1. A method of reducing viscosifying tendencies of crude oil in a subterranean formation comprising:combining an effective amount of a solid acid chelating agent and an aqueous acid solution to form a treatment fluid, wherein the solid acid chelating agent comprises N-phosphonomethyl iminodiacetic acid (PMIDA);
introducing the treatment fluid into the subterranean formation, wherein the subterranean formation has a bottomhole temperature in excess of 350° F.;
contacting the crude oil with the treatment fluid; and
preventing an increase in viscosity of the crude oil.

US Pat. No. 10,190,033

SALT-FREE FLUOROUS-INVERT EMULSION FLUID

Halliburton Energy Servic...

1. A method of treating a well comprising: providing a treatment fluid comprising:a fluorous oil external phase,
an internal phase comprising water and glycerol, wherein the glycerol is present in an amount of about 40% to about 80% by weight of the internal phase, and wherein the internal phase is salt and chloride free, and
a fluorous-based surfactant; and
introducing the treatment fluid into a wellbore.

US Pat. No. 10,190,032

VISCOELASTIC SURFACTANTS IN MIXED BRINES

M-I L.L.C., Houston, TX ...

17. A method of finding of finding an optimal ratio of divalent brine to monovalent brine in a wellbore fluid including a viscoelastic surfactant, the method comprising:providing a mixture of viscoelastic surfactant and a monovalent brine;
adding a divalent brine in incremental values, wherein the initial amount of divalent brine to be added is based upon a packing parameter of the viscoelastic surfactant; and
measuring the rheological properties.

US Pat. No. 10,190,030

TREATED GEOTHERMAL BRINE COMPOSITIONS WITH REDUCED CONCENTRATIONS OF SILICA, IRON AND LITHIUM

Alger Alternative Energy,...

1. A treated geothermal brine composition, the composition comprising a treated geothermal brine comprising lithium, silica, iron, and lead, and having a concentration of lithium of no more than 200 mg/kg, a concentration of silica of no more than 80 mg/kg, a concentration of iron of no more than 300 mg/kg, and a concentration of lead greater than 25 mg/kg, wherein the treated geothermal brine comprises recoverable amounts of one or more of metals selected from the group consisting of boron, cesium, and rubidium.

US Pat. No. 10,190,028

EPOXY TWO-PART FORMULATIONS

Dow Global Technologies L...

1. A resin composition for a two-part adhesive comprisinga) an epoxy compound having the formula
wherein each R? is independently hydrogen, methyl, ethyl, n-propyl or isopropyl;b) a polyurethane comprising an elastomeric portion including one or more soft segments selected from a polyether, a polybutadiene or polyester soft segment, the soft segment or segments each having a molecular weight of 1000 to 10,000 daltons, the polyurethane having an average of 2 to 4 isocyanate groups capped with a polyphenol;
c) a core shell rubber epoxy dispersion comprising core shell rubber particles having a rubbery core with a Tg of less than ?25° C. and a shell polymer polymerized from at least one lower alkyl methacrylate provided that up to 40% of the weight of the shell polymer can be formed from styrene, vinyl acetate, vinyl chloride, methyl acrylate, ethyl acrylate and butyl acrylate; wherein the core shell rubber particles are dispersed in an epoxy resin and
d) an alkyl diglycidyl ether comprising a linear C3-10 linear alkyl group that is glycidyl terminated.

US Pat. No. 10,190,021

FLOOR COATING COMPOSITIONS AND FLOORING MATERIAL

DEXERIALS AMERICA CORPORA...

1. A floor coating composition used for coating of a floor and comprising components (A) to (E) below as essential components:component (A): a bifunctional (meth)acrylate compound not having an alicyclic structure;
component (B1): a trifunctional or more urethane (meth)acrylate oligomer;
component (B2): a hexafunctional or more urethane (meth)acrylate oligomer other than the component (B1);
component (C): a melamine (meth)acrylate;
component (D): metal oxide nanoparticles; and
component (E): an active energy ray polymerization initiator,
wherein the amount of component (A) contained is more than 24 weight % and less than 50 weight %, the amount of component (B1) contained is more than 10 weight % and less than 35 weight %, the amount of component (B2) contained is not less than 10 weight % and not more than 15 weight %, and the amount of component (C) contained is not less than 10 weight % and less than 20 weight %, and
wherein component (E) contains a hydrogen abstraction photopolymerization initiator.

US Pat. No. 10,190,015

PASSIVATION LAYER COMPRISING A PHOTOCROSSLINKED FLUOROPOLYMER

THE CHEMOURS COMPANY FC, ...

1. A passivation layer comprising a layer of a photocrosslinked coating composition disposed on at least a portion of a substrate, wherein the coating composition consists essentially of:i) a photocrosslinkable fluoropolymer having repeat units comprising:
(a) a fluoroolefin;
(b) an alkyl vinyl ether wherein the alkyl group is a C1 to C6 straight or a C3 to C6 branched or cyclic saturated hydrocarbon radical; and
(c) a vinyl epoxide;
ii) a photoacid generator;
iii) an optional photosensitizer; and
iv) a carrier medium;
wherein the photocrosslinkable fluoropolymer has a number average molecular weight in the range of from 20,000 to 300,000, and, wherein the layer of photocrosslinked coating composition has a dielectric constant in the range of from 1 to 5 when measured at 100 kHz, and wherein the layer of the photocrosslinked coating composition having a thickness in the range of from 0.01 micrometers to 300 micrometers has photocrosslinked features having a minimum width that is the larger of a) about 10 percent the thickness of the coating composition or b) 0.5 micrometers.

US Pat. No. 10,190,007

INK, INK CONTAINER, IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND IMAGE FORMED MATTER

Ricoh Company, Ltd., Tok...

1. An ink, comprising:a colorant;
an organic solvent;
water; and
a surfactant comprising at least one polyether-modified siloxane compound selected from the group consisting of compounds of formulae (III), (IV), (V), and (VI),

where in the formula (III), m represents an integer in a range of from 0 through 23, n represents an integer in a range of from 1 through 10, a represents an integer in a range of from 1 through 23, b represents an integer in a range of from 0 through 23, and R represents a hydrogen atom or an alkyl group that comprises 1 through 4 carbon atoms,

where in the formula (IV), m represents an integer in a range of from 1 through 8, c and d represent an integer in a range of from 1 through 10, and R2 and R3 represent a hydrogen atom or an alkyl group that comprises 1 through 4 carbon atoms,

where in the formula (V), e represents an integer in a range of from 1 through 8 and R4 represents a hydrogen atom or an alkyl group that comprises 1 through 4 carbon atoms,

where in the formula (VI), f represents an integer in a range of from 1 through 8 and R5 represents a polyether group represented by the formula (A),

where in the general formula (A), g represents an integer in a range of from 0 through 23, h represents an integer in a range of from 0 through 23, where g and h do not take 0 at a same time, and R6 represents a hydrogen atom or an alkyl group that comprises 1 through 4 carbon atoms,
wherein the organic solvent comprises at least one organic solvent having a solubility parameter of greater than or equal to 9 but less than 11.8,
wherein a content of the organic solvent having a solubility parameter of greater than or equal to 9 but less than 11.8 is greater than or equal to 20% by mass of a total amount of the ink,
wherein a dynamic surface tension A of the ink at 25° C. at a surface lifetime, measured by a maximum foaming pressure method, of 15 msec is less than or equal to 34.0 mN/m, and
wherein the dynamic surface tension A and a static surface tension B of the ink at 25° C. satisfy a formula of 10.0%?[(A?B)/(A+B)]×100?19.0%.

US Pat. No. 10,190,004

PEELABLE COATING

Skudo Group Pty Ltd, Rob...

1. A method of applying a peelable and temporary protective coating to a floor during a construction phase of a commercial or residential premises, the method including the steps of:applying a liquid to the floor for forming a base layer, the base layer being peelable from the floor when dry; and
applying a pre-manufactured reinforcing layer atop the base layer while wet, and removing the base layer and reinforcing layer together after the phase.

US Pat. No. 10,189,998

DOPED NICKEL OXIDE INTERFACIAL LAYER

Hunt Energy Enterprises, ...

1. A photovoltaic device comprising:a first electrode;
a second electrode; and
an active layer disposed at least partially between the first and second electrodes, the active layer comprising: an NiO interfacial layer doped with copper that is adjacent to and in contact with a perovskite material photoactive layer.

US Pat. No. 10,189,982

CONTACTING COMPONENT AND STRUCTURE CONTAINING SAID CONTACTING COMPONENT

TECHNO POLYMER CO., LTD.,...

1. A contacting component comprising a molded article made from a thermoplastic resin composition (X) containing a vinyl graft polymer (A), a vinyl non-graft polymer (B) and a matting agent (C),wherein:
the vinyl graft polymer (A) contains an ethylene-?-olefin rubber polymer (a1).

US Pat. No. 10,189,978

RUBBER COMPOSITION COMPRISING A HIGHLY SATURATED DIENE ELASTOMER

COMPAGNIE GENERALE DES ET...

1. A rubber composition comprising a reinforcing filler and an elastomer matrix comprising a highly saturated diene elastomer,wherein the highly saturated diene elastomer comprises at least units of A, B, C, D and E, distributed randomly within the highly saturated diene elastomer:

wherein R1 and R2, which are identical or different, represent a hydrogen atom, a methyl radical or a phenyl radical, which is substituted or unsubstituted in the ortho, meta or para position by a methyl radical,
wherein (D) is a divalent hydrocarbon-based ring with 6 carbon atoms of 1,2-cyclohexane type,
wherein (E) is a divalent hydrocarbon-based ring with 6 carbon atoms of 1,4-cyclohexane type,
wherein m, n, o, p and q are numbers ranging from 0 to 100, and
wherein the highly saturated diene elastomer satisfies the following:
m+n+o+p+q=100,
m?50,
n+o+p+q?10, and
15?p+q?2.

US Pat. No. 10,189,975

CABLE FILL COMPOSITION

SHELL OIL COMPANY, Houst...

1. A cable fill composition for an optical fiber cable, said cable fill composition comprising (i) a Fischer-Tropsch derived base oil; and (ii) a thickening system, wherein the thickening system comprises at least one block copolymer.

US Pat. No. 10,189,967

MACROPOROUS PHOTONIC CRYSTAL MEMBRANE, METHODS OF MAKING, AND METHODS OF USE

UNIVERSITY OF FLORIDA RES...

1. A structure comprising:a macroporous photonic crystal membrane including a three dimensional array of macropores, wherein a three dimensional polymer framework separates the macropores, wherein the polymer framework is made of a copolymer of two oligomers, wherein the two oligomers are ethoxylated (20) trimethylolpropane triacrylate (ETPTA 20) and polyethylene glycol (600) diacrylate (PEGDA 600), wherein when the macropores are in a collapsed state, the macroporous photonic crystal membrane is substantially transparent and wherein when the macropores are in an uncollapsed state, the macroporous photonic crystal membrane has an iridescent color.

US Pat. No. 10,189,962

HEAT-SHRINKABLE POLYESTER FILM

TOYOBO CO., LTD., Osaka ...

1. A heat-shrinkable polyester film comprising ethylene terephthalate as a main component, containing not less than 0 mol % and not more than 5 mol % of a monomer component capable of serving as an amorphous component relative to the total of a polyester resin component, and having a main shrinkage direction in a lengthwise direction, wherein the heat-shrinkable polyester film satisfies the following requirements (1) to (3):(1) the heat-shrinkable polyester film has a hot-water heat shrinkage rate in the lengthwise direction of not less than 15% and not more than 60% when being treated in hot water at 90° C. for 10 seconds;
(2) the heat-shrinkable polyester film has a hot-water heat shrinkage rate in a width direction orthogonal to the lengthwise direction of not less than ?10% and not more than 10% when being treated in hot water at 90° C. for 10 seconds; and
(3) the heat-shrinkable polyester film has an orientation distortion index that is a molecular orientation angle difference, the difference being a difference between a molecular orientation angle of an edge of one end in the width direction and a molecular orientation angle of an edge of the other end, per 1 m of the film of not more than 15°/m.

US Pat. No. 10,189,961

CREEP RESISTANT, HIGHLY LUBRICIOUS, TOUGH, AND IONIC HYDROGELS INCLUDING PVA-PAAMPS HYDROGELS

The General Hospital Corp...

1. A method of making a creep resistant, highly lubricious, tough and ionic hydrogel comprising:a) mixing an aqueous solution of a polymer with an aqueous solution of an ionic monomeric compound in presence of an initiator, thereby forming an ionic hydrogel solution, wherein the aqueous solution of the polymer comprises 1% w/w to 25% w/w of the polymer, and wherein the aqueous solution of the ionic monomeric compound comprises 5% w/w to 25% w/w of the ionic monomeric compound;
b) heating and/or irradiating the ionic hydrogel solution, thereby forming an inter-penetrating network (IPN) structure of polymerized ionic hydrogel in the aqueous polymer solution; and
c) subjecting the inter-penetrating network (IPN) structure of polymerized ionic hydrogel in the aqueous polymer solution to one or more freeze-thaw cycles to physically-crosslink the polymer, thereby forming a creep resistant, highly lubricious, tough and ionic hydrogel, and
d) annealing the ionic hydrogel,
wherein the polymer is poly(vinyl alcohol) (PVA), and the ionic monomeric compound is a acrylamido-methylpropane sulfonic acid (AAMPS) solution, and the inter-penetrating network (IPN) structure of polymerized ionic hydrogel is an inter-penetrating network (IPN) structure of polymerized PAAMPS, and the creep resistant, highly lubricious, tough and ionic hydrogel is a creep resistant, highly lubricious, tough and ionic PVA-PAAMPS-hydrogel.

US Pat. No. 10,189,958

ORGANIC POLYMERIC PARTICLES, PAPER COATING COMPOSITIONS AND METHODS

OMNOVA Solutions, Inc., ...

1. A coated paper comprising:a base paper having a first and a second surface; and
a paper coating composition applied to the first, the second, or both the first and second surfaces, where the paper coating composition comprises a binder and a hollow porous particle; and
where the hollow porous particle was prepared by a process that includes
(i) providing an organic polymeric particle including a core including a polymer including units deriving from the polymerization of acrylate monomer; and a shell surrounding the core, where the shell includes a polymer having units deriving from the polymerization of styrene monomer and acrylate monomer selected from methyl acrylate, butyl acrylate, and combinations thereof; where the shell includes polymer having from 70 to 98 weight units deriving from the polymerization of styrene monomer, and from 2 to 30 weight units deriving from the polymerization of acrylate monomer; and
(ii) subjecting the organic polymeric particle to conditions that will hydrolyze the units deriving from the polymerization of acrylate monomer within the shell and the core, to thereby provide a hollow porous particle.

US Pat. No. 10,189,954

SYNTHESIS OF ANTIMICROBIAL SILSESQUIOXANE-SILICA HYBRIDS

Kimmerling Holdings Group...

1. A method of preparing a silsesquioxane-silica hybrid, comprising:hydrolytically co-condensing, in the presence of at least one (C1-C3)alcohol and a catalytic amount of an ammonium cation (NH4+), of a tetraalkoxysilane of formula I:
with a trialkoxysilane of formula II:and with a trialkoxysilane of formula III:wherein said compound of formula II, said compound of formula I, and said compound of formula III are reacted in a molar ratio of about 1:1-32:1, respectively; wherein:A1, A2, A3, and A4 are each independently selected from the group consisting of H, C1-C8alkyl, and trifluoro-substituted (C1-C8)alkyl;
Ra is independently a functional group comprising at least one curing group selected from the group consisting of acrylate, methacrylate, (C2-C8)alkenyl, glycidyloxy, epoxy, sulfonate, carboxylate, ester, amino, acrylamide, methacrylamide, isocyanato, amino acid, nucleic acid, and mercapto(C1-C6)alkyl;
Rb is independently

wherein:
Rc is (C1-C2)alkyl;
Rd is (C1-C2)alkyl or phenyl;
Re is (C6-C22)alkyl;
X?is an anion selected from the group consisting of chloride, bromide, fluoride, iodide, sulfonate, and acetate;
each RY is, independently, H, (C1-C8)alkyl, or trifluoro-substituted (C1-C8)alkyl.

US Pat. No. 10,189,948

ISATIN COPOLYMERS HAVING INTRINSIC MICROPOROSITY

Dow Global Technologies L...

1. A copolymer comprising a repeating unit represented by:wherein:Y is selected from: a carboxylic acid, sulfonic, phosphorous acid and phosphoric acid and their corresponding salt or ester, imino, amide; nitrile, hydrogen, hydroxyl and alkyl comprising from 1 to 6 carbon atoms; and
R1, R2, R3, and R4 are independently selected from: hydrogen, alkyl groups comprising from 1 to 6 carbon atoms, and R1 and R2 may collectively form a ketone group or a 9,9?-fluorene group, and R3 and R4 may collectively form a ketone group or a 9,9?-fluorene group;
R5 and R6 are independently selected from: a bond and an alkylene group comprising from 1 to 6 carbon atoms;
R7 is selected from: hydrogen, alkyl, aryl, aralkyl and heteroaryl groups comprising from 1 to 8 carbon atoms which may be unsubstituted or substituted with carboxylic acid, sulfonic acid and phosphoric acid and their corresponding salt or ester, imino and amide; and
X and X? are independently selected from: a carboxylic acid, sulfonic acid and phosphoric acid and their corresponding salt or ester, imino and amide; nitrile, hydrogen, alkyl having from 1 to 6 carbon atoms and alkoxy having from 1 to 6 carbon atoms.

US Pat. No. 10,189,947

COMPOSITION OF ANTI-REFLECTIVE HARDMASK

1. An anti-reflective hardmask composition comprising:(a) a carbazole derivative polymer represented by the following Formula 1 or a polymer blend comprising the carbazole derivative polymer; and
(b) an organic solvent:

where R1 is hydrogen or an aromatic ring selected from the group consisting of the following substituents, R2 is an aromatic ring selected from the group consisting of the following substituents, and R1 and R2 may be the same or different:

where X is at least one selected from the following substituents:

where Z is an integer of 0 or 1,
m/(m+n) equals to a value in the range of between 0.1 and 0.8, and
a weight average molecular weight (Mw) of the polymer is between 1,000 and 30,000.

US Pat. No. 10,189,929

ACTIVE-ENERGY-RAY-CURABLE COMPOSITION FOR OPTICAL MEMBERS, CURED ARTICLE, AND OPTICAL LENS AND SHEET OR FILM FOR OPTICAL LENSES EACH PRODUCED USING SAID CURED ARTICLE

SANYO CHEMICAL INDUSTRIES...

1. An active energy ray-curable composition for optical components, wherein the composition is composition (I) or composition (II),the composition (I) comprising:
a monomer (A) having 2 or more radical-polymerizable reactive groups (x1), wherein the homopolymer of the monomer (A) has a glass transition temperature of higher than 200° C.;
a monomer (B) having 2 or more radical-polymerizable reactive groups (x3), wherein the homopolymer of the monomer (B) has a glass transition temperature of ?15° C. or higher and 100° C. or lower, wherein the monomer (B) comprises a (meth)acrylate having 2 to 6 radical-polymerizable reactive groups (x3) and in a molecule, 1 to 15 organic groups (b) represented by the following formula (5):

wherein p represents 4 or 5;
a monomer (C) having 2 or more radical-polymerizable reactive groups (x2), wherein the homopolymer of the monomer (C) has a glass transition temperature of lower than ?15° C., wherein the monomer (C) comprises a polyfunctional (meth)acrylate represented by the following formula (1):
wherein X represents a hydroxyl group, a methyl group, a (meth)acryloyloxy group, a group represented by the formula (2), or a group represented by the formula (3):R1 to R3 and R each represent a hydrogen atom or a methyl group and may be the same as or different from one another, Y1 to Y5 each represent a C2-C4 oxyalkylene group and may be the same as or different from one another, and a, b, c, d, and e independently represent an integer of 0 to 10, provided that a+b+c+d+e is 6 to 40, and/ora bifunctional (meth)acrylate represented by the following formula (4):wherein R4 and R5 independently represent a hydrogen atom or a methyl group, and m and n independently represent an integer of 3 to 10;a slip agent (D); and
a photopolymerization initiator (E), wherein the photopolymerization initiator (E) comprises a phosphine oxide compound (E1) and/or a hydroxy benzoyl compound (E5),
wherein the radical-polymerizable reactive groups (x1), (x2) and (x3) are each at least one group selected from the group consisting of an acrylate group and a methacrylate group,
wherein the composition contains 41% to 59% by weight of the monomer (A) and 41% to 59% by weight of the monomer (C) based on the total weight of the monomers (A) and (C),
15% to 20% by weight of the monomer (B) based on the total weight of the monomers (A), (B), and (C),
0.8 to 5% by weight of the slip agent (D) based on the total weight of the monomers (A) and (C), and
1 to 8% by weight of the photopolymerization initiator (E) based on the total weight of the monomers (A) and (C); and
the composition (II) comprising:
a monomer (A) having 2 or more radical-polymerizable reactive groups (x1), wherein the homopolymer of the monomer (A) has a glass transition temperature of higher than 200° C.;
a monomer (C) having 2 or more radical-polymerizable reactive groups (x2), wherein the homopolymer of the monomer (C) has a glass transition temperature of lower than ?15° C., wherein the monomer (C) comprises a polyfunctional (meth)acrylate represented by the above formula (1) and a bifunctional (meth)acrylate represented by the above formula (4); and
a slip agent (D); and
a photopolymerization initiator (E), wherein the photopolymerization initiator (E) comprises a phosphine oxide compound (E1) and/or a hydroxy benzoyl compound (E5),
wherein the radical-polymerizable reactive groups (x1) and (x2) are each at least one group selected from the group consisting of an acrylate group and a methacrylate group,
wherein the composition contains 9% to 40% by weight of the monomer (A) and 60 to 91% by weight of the monomer (C) based on the total weight of the monomers (A) and (C),
20% to 60% by weight of the polyfunctional (meth)acrylate represented by the above formula (1) and 30% to 55% by weight of the bifunctional (meth)acrylate represented by the above formula (4) based on the total weight of the monomers (A) and (C),
0.8 to 5% by weight of the slip agent (D) based on the total weight of the monomers (A) and (C), and
1 to 8% by weight of the photopolymerization initiator (E) based on the total weight of the monomers (A) and (C).

US Pat. No. 10,189,928

CURABLE COMPOSITION, PATTERN FORMING METHOD, PATTERN, AND METHOD FOR MANUFACTURING DEVICE

FUJIFILM Corporation, To...

1. A curable composition comprising:a polymerizable compound; and
a photopolymerization initiator,
wherein neopentyl glycol diacrylate accounts for 10% by mass or more of the polymerizable compound, and
the total content of a compound represented by the following Formula (I) and a compound represented by the following Formula (II) is 5% by mass or less with respect to the content of neopentyl glycol diacrylate:

US Pat. No. 10,189,877

TETRAVALENT DENGUE VACCINE

International Centre for ...

1. A virus like particle (VLP) comprising:a) a recombinant polypeptide comprising an EDIII domain of each of Dengue virus serotypes DENV-1, DENV-2, DENV-3 and DENV-4, linked to N-terminal of an HBsAg polypeptide, as depicted below:
EDIII-1-EDIII-3-EDIII-4-EDIII-2-HBsAg;
wherein the dotted line is a linker; and
wherein the amino acid sequence of the EDIII domain of each of Dengue virus serotypes DENV-1, DENV-2, DENV-3 and DENV-4 is SEQ ID NO's 1, 2, 3 and respectively; and
b) 4 units of an HBsAg polypeptide.

US Pat. No. 10,189,870

CRYSTALLINE FORM OF OXAZOLIDINONE ANTIBIOTICS AND PREPARATION METHOD, COMPOSITION AND USE THEREOF

HANGZHOU PUSHAI PHARMAEUT...

1. Form II of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate represented by the following structural formula:
measured with Cu—K? radiation, the X-ray powder diffraction pattern of the Form II, expressed as 2? angles, has the following characteristic peaks: 10.5±0.2°, 15.7±0.2°, 16.5±0.2°, 17.3±0.2°, 21.0±0.2° and 26.3±0.2°.

US Pat. No. 10,189,866

LITHIUM SECONDARY BATTERY, ELECTROLYTE SOLUTION FOR LITHIUM SECONDARY BATTERY, AND ADDITIVE FOR ELECTROLYTE SOLUTION THEREFOR

HITACHI, LTD., Tokyo (JP...

1. A lithium secondary battery comprising:a positive electrode having a lithium-ion intercalation/de-intercalation ability;
a negative electrode having a lithium-ion intercalation/de-intercalation ability; and
a non-aqueous electrolyte solution contacted with the positive electrode and the negative electrode, wherein
the non-aqueous electrolyte solution contains lithium hexafluorophosphate and a boroxine compound liquefying at 25° C. selected from the group consisting of (O+CH2CH2CH2CH3)3(BO)3 and (O—CH(CH3)CH2CH3)3(BO)3.

US Pat. No. 10,189,850

CDK INHIBITORS

G1 Therapeutics, Inc., R...

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of the compound of the structure:
wherein the pharmaceutical composition is in the form of a liquid dosage form.

US Pat. No. 10,189,844

PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS

CHIESI FARMACEUTICI S.p.A...

1. A compound of formula (I):
wherein:
R1 and R4 and R5 may be the same or different and are each independently (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, (C1-C6) aminoalkyl, or aryl, each of which is optionally and independently substituted by one or more groups selected from the group consisting of halogen, —OH, —(CH2)pNR6R7, —CN, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, and (C2-C6) hydroxyalkynyl;
R2 is H or (C1-C6) alkyl;
R3 is H;
Cy is a heteroaryl selected from the group consisting of I-1, I-2, and I-3 wherein I-1 is purinyl, I-2 is pyrazolo[3,4-d]pyrimidinyl, and I-3 is pyrimidinyl; each of which may be optionally and independently substituted by one or more groups selected from the group consisting of halogen, —OH, —(CH2)pNR6R7, —CN, —CH?NOH, —C(O)NR6R7, —C(O)OR6, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, (C1-C6) alkanoyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C2-C6) hydroxyalkynyl, aryl, heteroaryl, and heterocycloalkyl, wherein said aryl, heteroaryl, and heterocycloalkyl may be optionally and independently substituted with one or more groups selected from the group consisting of —OH, halogen, —CN, —S(O)2NR6R7, —NR6S(O)2R7, —NR6R7, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, and (C1-C6)alkoxy;
R6 and R7 may be the same or different and are each independently —H and (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, (C1-C6) aminoalkyl, (C1-C6) alkanoyl, or aryl (C1-C6) alkanoyl or, when R6 and R2 are both linked to a nitrogen atom, they may form, taken together with the nitrogen atom to which they are linked, a 4 to 6 membered heterocycle optionally containing one or more additional heteroatom or heteroatomic group selected from the group consisting of O, S, N, and NH; and
p is at each occurrence independently zero or an integer ranging from 1 to 3;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,841

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

FORMA Therapeutics, Inc.,...

9. A pharmaceutical composition comprising, a compound of claim 1, and a pharmaceutically acceptable carrier.

US Pat. No. 10,189,840

SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS

Bristol-Myers Squibb Comp...

1. A compound of Formula (I)or a salt thereof, wherein:X is N;
W is:
(i) —(CR3R3)1-4—;
(ii) —(CR3R3)x—Y—(CR3R3)y—; or
(iii) —Y—(CR3R3)2—Y—;
each Y is independently O, NR4, or S(O)p;
x is zero, 1, 2, or 3;
y is zero, 1, 2, or 3, provided that (x+y) is zero, 1, 2, or 3;
R1 is H, R1a, C1-6 haloalkyl, C2-6 alkenyl substituted with zero to 6 R1a, C2-6 alkynyl substituted with zero to 4 R1a, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R2 is H, halo, —CN, —CF3, —OCF3, —NO2, C1-6 alkyl substituted with zero to 6 R1a, —(CRgRg)rORe, —(CRgRg)rNRcRc, —(CRgRg)rS(O)pRb, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic heteroaryl substituted with zero to 3 R1a);
each R3 is independently H, halo, —CN, —OH, —OCF3, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —(CRgRg)rC(O)Rb, —(CRgRg)rC(O)ORb, —(CRgRg)rC(O)NRcRc, —(CRgRg)rORe, —(CRgRg)rOC(O)Rb, —(CRgRg)rOC(O)NRcRc, —(CRgRg)rOC(O)ORd, —(CRgRg)rNRcRc, —(CRgRg)rNRbC(O)Rd, —(CRgRg)rNRbC(O)ORd, —(CRgRg)rNRbC(O)NRcRc, —(CRgRg)rNRbS(O)pRd, —(CRgRg)rS(O)pRb, —(CRgRg)rS(O)pNRcRc, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
each R4 is independently H, C1-6 alkyl substituted with zero to 6 R1a, C3-7 cycloalkyl substituted with zero to 6 R1a, —C(O)Rb, —C(O)NRcRc, —C(O)ORb, —S(O)2Rb, —S(O)2NRcRc, —S(O)2ORb, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic heteroaryl substituted with zero to 3 R1a);
R5 is —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-10 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R6 is H, C1-6 alkyl, or C1-6 haloalkyl;
or R5 and R6 together with the carbon atom to which they are attached form a 5- to 6-membered spirocarbocyclyl ring or a spiroheterocyclyl ring, each substituted with zero to 6 R5a;
each R5a is independently selected from H, halo, —CN, —OH, C1-3 alkyl, C1-3 fluoroalkyl, or C1-3 alkoxy; or two R5a attached to neighboring carbon atoms of the spirocarbocyclic ring or the spiroheterocyclic ring, form a benzo ring along with the carbon atoms to which they are attached, said benzo substituted with zero to 4 Rf; or two R5a attached to the same carbon atom of the spirocarbocyclic ring or the spiroheterocyclic ring, form ?O;
R8 is H, halo, —CN, C1-6 haloalkyl, or C1-3 alkoxy;
each R1a is independently F, Cl, —CN, C1-6 alkyl substituted with zero to 6 Ra, C3-6 cycloalkyl substituted with zero to 6 Ra, C1-3 alkoxy substituted with zero to 6 Ra, C1-3 haloalkoxy, heterocycloalkyl substituted with zero to 6 Ra, aryl substituted with zero to 6 Ra, mono- or bicyclic heteroaryl substituted with zero to 6 Ra, —C(O)Rb, —C(O)ORb, —C(O)NRcRc, —OC(O)Rb, —OC(O)NRcRc, —OC(O)ORd, —NRcRc, —NRbC(O)Rd, —NRbC(O)ORd, —NRbS(O)pRd, —NRbC(O)NRcRc, —NRbS(O)pNRcRc, —S(O)pRb, —S(O)pNRcRc, or —C(O)NRb(CH2)1-3NRcRc;
each Ra is independently halo, —CN, —OH, —NO2, —NH2, C1-3 alkyl, C1-3 fluoroalkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 fluoroalkoxy, —C(O)OH, —C(O)(C1-3 alkyl), —C(O)O(C1-4 alkyl), —OC(O)(C1-3 alkyl), —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —C(O)NH(C1-3 alkyl), —OC(O)NH(C1-3 alkyl), —NHC(O)NH(C1-3 alkyl), —C(?NH)(NH2), C3-7 carbocyclyl, aryl, 5-7 membered heterocyclyl, mono- or bicyclic heteroaryl, —O(aryl), —O(benzyl), —O(heterocyclyl), —S(C1-3 alkyl), —S(aryl), —S(heterocyclyl), —S(O)(aryl), —S(O)(heterocyclyl), S(O)2(aryl), —S(O)2(heterocyclyl), —NHS(O)2(aryl), —NHS(O)2(heterocyclyl), —NHS(O)2NH(aryl), —NHS(O)2NH(heterocyclyl), —NH(aryl) —NH(heterocyclyl), —NHC(O)(aryl), —NHC(O)(C1-3 alkyl), —NHC(O)(heterocyclyl), —OC(O)(aryl), —OC(O)(heterocyclyl), —NHC(O)NH(aryl), —NHC(O)NH(heterocyclyl), —OC(O)O(C1-3 alkyl), —OC(O)O(aryl), —OC(O)O(heterocyclyl), —OC(O)NH(aryl), —OC(O)NH(heterocyclyl), —NHC(O)O(aryl), —NHC(O)O(heterocyclyl), —NHC(O)O(C1-3 alkyl), —C(O)NH(aryl), —C(O)NH(heterocyclyl), —C(O)O(aryl), —C(O)O(heterocyclyl), —N(C1-3 alkyl)S(O)2(aryl), —N(C1-3 alkyl)S(O)2(heterocyclyl), —N(C1-3 alkyl)S(O)2NH(aryl), —N(C1-3 alkyl)S(O)2NH(heterocyclyl), —N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)(aryl), —N(C1-3 alkyl)C(O)(heterocyclyl), —N(C1-3 alkyl)C(O)NH(aryl), —(CH2)0-3C(O)NH(heterocyclyl), —OC(O)N(C1-3 alkyl)(aryl), —OC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)O(aryl), —N(C1-3 alkyl)C(O)O(heterocyclyl), —C(O)N(C1-3 alkyl)(aryl), —C(O)N(C1-3 alkyl)(heterocyclyl), —NHS(O)2N(C1-3 alkyl)(aryl), —NHS(O)2N(C1-3 alkyl)(heterocyclyl), —NHP(O)2N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(heterocyclyl), or —Si(C1-3 alkyl)3;
each Rb is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rc is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf; or when attached to the same nitrogen, two Rc along with the nitrogen atom to which they are attached form 4-8 membered heterocyclic ring optionally substituted with Rg;
each Rd is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Re is independently H, C1-6 alkyl substituted with zero to 6 Rf, C1-3 haloalkyl, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rf is independently H, halo, —OH, —CN, C1-6 alkyl substituted with zero to 6 Ra, C1-3 alkoxy, C3-7 cycloalkyl substituted with zero to 6 Ra, heterocycloalkyl substituted with zero to 6 Ra, aryl substituted with zero to 3 Ra, or mono- or bicyclic heteroaryl substituted with zero to 3 Ra;
each Rg is independently H, F, —OH, —CN, C1-3 alkyl, —CF3, or phenyl;
each p is independently zero, 1, or 2; and
each r is independently zero, 1, 2, 3, or 4.

US Pat. No. 10,189,839

TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE

ACTELION PHARMACEUTICALS ...

1. A compound of Formula (I)
wherein
X represents —CH2—, —CH2—CH2—, —CH2—CH2—CH2—, —S—, *—CH2—O—, or *—CH2—NRx— wherein Rx represents hydrogen, —CO—(C1-4)alkyl, —(C1-3)alkyl-(C3-6)cycloalkyl, (C3-6)cycloalkyl, or —CO—(C1-4)alkoxy; wherein the asterisks indicate the bond attached to the imidazole ring;
R1a and R1b independently represent hydrogen, methyl, ethyl; or R1a and R1b together with the carbon atom to which they are attached to form a cyclopropyl ring;
R2 represents aryl, or heteroaryl, wherein said aryl or heteroaryl independently is unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from:
(C1-4)alkyl;
(C1-4)alkoxy;
(C3-6)cycloalkyl;
(C1-3)fluoroalkyl;
(C1-3)fluoroalkoxy;
halogen;
cyano;
—(CH2)n—NR21R22; wherein n represents the integer 0 or 1; and
R21 and R22 independently represent hydrogen or (C1-4)alkyl; or
R21 and R22 together with the nitrogen atom to which they are attached to form a 4- to 7-membered saturated ring, wherein said ring optionally includes one ring oxygen atom;
—CO—NR23R24, wherein R 23 and R24 independently represent hydrogen or (C1-4)alkyl;
—CO—NH—CN;
—NR25—CO—NR26R27, wherein R25, R26 and R27 independently represent hydrogen or (C1-4)alkyl;
—CO—(C1-4)alkoxy;
phenyl;
hydroxy-(C1-4 )alkyl;
(C1-3)alkoxy-(C1-4)alkyl;
hydroxy-(C2-4)alkoxy; or
(C1-3)alkoxy-(C2-4)alkoxy;
R3 represents aryl, or heteroaryl, wherein said aryl or heteroaryl independently is unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from:
—NR4—Y—R5, wherein
R4 represents hydrogen or (C1-3)alkyl; Y represents a direct bond; and R5 represents (C1-4)alkyl, or (C3-6)cycloalky; or
R4 represents hydrogen or (C1-3)alkyl; Y represents —NRY— wherein RY represents (C1-3)alkyl; and R5 represents (C1-4)alkyl; or
R4 and R5 together with the nitrogen and the —SO2—Y-group to which they are attached to form a 5-, 6-, or 7-membered ring, wherein Y represents a direct bond or —NRY— wherein RY represents (C1-3)alkyl;
—CO—NR6R7, wherein R6 and R7 independently represent hydrogen, (C1-4)alkyl, or (C3-6)cycloalkyl;
—SO2—R8 wherein R8 represents (C1-5)alkyl, or —NR81R82, wherein R81 and R82 independently represent hydrogen or (C1-4)alkyl;
—(CH2)m—NR9R10; wherein m represents the integer 0 or 1; and
R9 and R10 independently represent hydrogen, (C1-4)alkyl, (C2-3)fluoroalkyl, hydroxy-(C2-4)alkyl, (C1-4)alkoxy-(C2-4)alkyl; or
R9 and R10 together with the nitrogen to which they are attached to form a 4-to 7-membered ring optionally including an oxygen ring atom or a group —NR11— wherein
R11 represents (C1-4)alkyl, and wherein said ring is optionally substituted with one or two fluorine substituents;
(C1-4)alkyl;
(C3-6)cycloalkyl;
(C1-4)alkoxy;
(C1-3)fluoroalkyl;
(C1-3)fluoroalkoxy;
halogen;
cyano; or
5-membered heteroaryl;or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,834

IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER

AstraZeneca AB, Sodertal...

1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, where:Q is a cyclobutyl or cyclopentyl ring, each of which is optionally substituted by one hydroxy or methoxy group, or Q is an oxetanyl, tetrahydrofuranyl or oxanyl ring, each of which is optionally substituted by one methyl group;
R1 is methyl;
R2 is hydrogen or methyl; or R1and R2 together form an azetidinyl, pyrrolidinyl or piperidinyl ring;
R3 is hydrogen or fluoro;
R4 is hydrogen or methyl; and
R5 is hydrogen or fluoro.

US Pat. No. 10,189,829

INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE

BIOGEN MA INC., Cambridg...

1. A compound represented by the following formula:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,825

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

SUNOVION PHARMACEUTICALS ...

1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein
X is selected from S and O;
one of R1a and R1b is

wherein
R5 is selected from hydrogen, alkyl, and C3-20 cycloalkyl;
R6 is selected from hydrogen, cyano, amino, alkylamino, alkyl, alkoxyl, alkenyl, alkynyl, C3-20 cycloalkyl, C3-20 cycloalkyl-C1-20 alkyl, C6-20 aryl, C6-20 aryl-C1-20 alkyl, C3-20 heterocyclyl with 1-2 heteroatoms selected from O, N, S, and combinations thereof, and C5-20 heteroaryl with 1-2 heteroatoms selected from O, N, S, and combinations thereof,
R7, and R8 are each independently selected from hydrogen, halo, cyano, amino, alkylamino, alkyl, alkoxyl, alkenyl, alkynyl, C3-20 cycloalkyl, C3-20 cycloalkyl-C1-20 alkyl, C6-20 aryl, C6-20 aryl-C1-20 alkyl, C3-20 heterocyclyl with 1-2 heteroatoms selected from O, N, S, and combinations thereof, and C5-20 heteroaryl with 1-2 heteroatoms selected from O, N, S, and combinations thereof;
and the other of R1a and R1b is selected from hydrogen, halo, cyano, alkyl, alkoxyl, alkenyl, alkynyl, C3-20 cycloalkyl, C3-20 cycloalkyl-C1-20 alkyl, C6-20 aryl, C6-20 aryl-C1-20 alkyl, C3-20 heterocyclyl with 1-2 heteroatoms selected from O, N, S, and combinations thereof, and C5-20 heteroaryl with 1-2 heteroatoms selected from O, N, S, and combinations thereof; and
R2 and R3 and the atoms to which they are attached form a benzene ring,
wherein each amino, alkylamino, alkyl, alkoxyl, alkenyl, alkynyl, C3-20 cycloalkyl, C3-20 cycloalkyl-C1-20 alkyl, C6-20 aryl, benzene ring, C6-20 aryl-C1-20 alkyl, C3-20 heterocyclyl, and C5-20 heteroaryl thereof is optionally substituted.

US Pat. No. 10,189,821

FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR I

Cancer Research Technolog...

1. A compound of formula I shown below:
wherein:
A1 is selected from N or CR1, A2 is selected from N or CR2, with the proviso that only one of A1 or A2 can be N;
R1 and R2 are each independently selected from hydrogen, fluoro, chloro, cyano, (1-2C)alkyl, (1-2C)alkoxy, (1-2C)haloalkyl or (1-2C)haloalkoxy;
R4 is selected from fluoro, chloro, bromo, iodo, CF3, OCF3, cyano, NO2, (1-4C)alkyl, (1-4C)alkoxy, or a group of the formula:
W—X-Y—Z
wherein
W is absent or (1-3C)alkylene;
X is —O— or —N(Ra)—, wherein Ra is selected from hydrogen or (1-2C)alkyl;
Y is absent or a (1-3C)alkylene;
Z is hydrogen, (1-6C)alkyl or (3-6C)cycloalkyl;
and wherein any alkylene, alkyl or cycloalkyl group present in a R4 substituent group is optionally further substituted by one or more substituent groups independently selected from halo, hydroxy, NRbRc, (1-2C)alkoxy, (1-2C)haloalkyl or (1-2C)haloalkoxy, and wherein Rb and Rc are each independently selected from hydrogen or (1-3C)alkyl;
Q is a group of formula III:

wherein
A5 is selected from N or CR5, where R5 is selected from hydrogen, halo, cyano, nitro, hydroxy, NRqRu, (1-3C)alkyl, (1-3C)alkoxy, 5 or 6-membered heteroaryl, or 5 or 6 membered heterocyclyl; wherein Rq and Ru are each independently selected from hydrogen or (1-3C)alkyl, and wherein any (1-3C)alkyl, (1-3C)alkoxy, 5 or 6-membered heteraryl, or 5 or 6 membered heterocyclyl group present in a R5 substituent group is optionally substituted by one or more substituents selected from halo, cyano, nitro, hydroxy, NRvRw, or (1-3C)alkoxy, wherein Rv and Rw are each independently selected from hydrogen or (1-3C)alkyl;
Ring A is:
a fused phenyl ring;
a fused 5 or 6 membered carbocyclic ring;
a fused 5 or 6 membered heteroaryl ring comprising one or two heteroatoms independently from N, S or O; or
a fused 5, 6 or 7-membered heterocyclic ring comprising one or two heteroatoms independently from N, S or O;
A6 is selected from N, O, S, S(O), S(O)2, CR6, C(R6)2, NR60, where R6 is selected from hydrogen, oxo, fluoro, chloro, (1-2C)alkyl, (1-2C)alkoxy, (1-2C)haloalkoxy or (1-2C)haloalkyl and R60 is hydrogen, ?O, (1-6C)alkyl, —C(O)—R61, —C(O)O—R61, or
—C(O)N(R62)R61, wherein R61 is selected from hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, aryl, heteroaryl or heterocyclyl and R62 is selected from hydrogen or (1-3C)alkyl;
A7 is selected from N, O, CR7, S, S(O), S(O)2, C(R7)2, NR70, where R70 is hydrogen, ?O, (1-6C)alkyl, —C(O)—R71, —C(O)O—R71, or —C(O)N(R72)R71, wherein R71 is selected from hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, aryl, heteroaryl or heterocyclyl and R72 is selected from hydrogen or (1-3C)alkyl;
m is 0, 1 or 2;
R7 and R11 are each independently halo, cyano, oxo, or a group
W2—X2—Y2—X3—Z2
wherein
W2 is absent or a linker group of the formula —[CRxRy]r— in which r is an integer selected from 1, 2, 3 or 4, and Rx and Ry are each independently selected from hydrogen or (1-2C)alkyl;
X2 is absent, —O—, —C(O)—, —C(O)O—, —OC(O)—, —CH(ORz)—, —N(Rz)—, —N(Rz)—C(O)—, —N(Rz)—C(O)O—, —C(O)—N(Rz)—, —N(Rz)C(O)N(Rz)—, —S—, —SO—, —SO2—, —S(O)2N(Rz)—, or
—N(Rz)SO2, wherein
Rz is selected from hydrogen or methyl;
Y2 is absent or a linker group of the formula —[CRaaRbb]s— in which s is an integer selected from 1, 2, 3 or 4, and Raa and Rbb are each independently selected from hydrogen or (1-2C)alkyl;
X3 is absent, —O—, —C(O)—, —C(O)O—, —OC(O)—, —CH(ORcc)—, —N(Rcc)—, —N(Rcc)—C(O)—, —N(Rcc)—C(O)O—, —C(O)—N(Rcc)—, —N(Rcc)C(O)N(Rcc)—, —S—, —SO—, —SO2—, —S(O)2N(Rcc)—, or —N(Rcc)SO2, wherein Rcc is selected from hydrogen or methyl; and
Z2 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, aryl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, heteroaryl, or heterocyclyl,
and wherein Z2 is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, nitro, hydroxy, carboxy, NRddRee, (1-4C)alkoxy, (1-4C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-3C)alkyl, (1-4C)alkanoyl, (1-4C)alkylsulphonyl, aryl, aryloxy, heterocyclyl, heterocyclyloxy, heterocyclyl-(1-2C)alkyl, heteroaryl, heteroaryloxy, heteroaryl-(1-2C)alkyl, C(O)NRddRee, NRddC(O)Ree, NRddSO2Ree and SO2NRddRee; wherein Rdd and Ree are each independently selected from hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl or (3-6C)cycloalkyl(1-2C)alkyl; or Rdd and Ree can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-6 membered heterocyclic ring; and
wherein any alkyl, aryl, heterocyclyl or heteroaryl group present in a substituent group on Z2 is optionally further substituted by halo, cyano, nitro, hydroxy, carboxy, NRffRgg, (1-2C)alkoxy, or (1-2C)alkyl; wherein Rff and Rgg are selected from hydrogen or (1-2C)alkyl;
with the proviso that when R7 is hydrogen (i.e. when W2, X2, Y2, and X3 are absent and Z2 is hydrogen) then ring A is not a fused dioxane ring;
or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,189,816

SUBSTITUTED PYRIDINES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

ViiV HEALTHCARE UK (NO. 5...

2. A compound of claim 1, wherein the compound is:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,814

ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME

Celgene Corporation, Sum...

1. A method for treating or managing a disease or disorder for therapeutic benefit comprising administering to a patient a therapeutically effective amount of a compound of formula (IV):
or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, wherein:
X is NR11 or NR12 when only one of R11 and R12 is attached to X, or X is CR11R12 when both R11 and R12 are attached to X;
Y is CH2 or C?O;
R11 and R12 are each independently hydrogen, —(C1-C6)alkyl, —(C1-C6)alkyl-(C3-C6)cycloalkyl, —(C1-C6)alkoxy, —(C6-C10)aryl, —CO(C1-C6)alkyl, —CO(C3-C6)cycloalkyl, —CO(C6-C10)aryl, —COO(C1-C6)alkyl, halogen, hydroxyl, oxo, 3 to 10 membered heterocycle, 6 to 10 membered heteroaryl, —NHCO(C1-C6)alkyl, —(CH2)n-phenyl, —SO2(C1-C6)alkyl, —SO2(C3-C6)cycloalkyl, —SO2(C6-C10)aryl or —NR14R15, wherein the alkyl, aryl or heteroaryl portion of each of the groups may be optionally substituted with one or more halogen, hydroxyl or —(C1-C6)alkoxy;
R13 is hydrogen or —(C1-C6)alkyl;
R14 and R15 are each independently hydrogen or —(C1-C6)alkyl; and
n is 0, 1, 2 or 3; and
wherein the disease or disorder is cancer, a disorder associated with angiogenesis, pain, macular degeneration, a skin disease, a parasitic disease, CNS injury, atherosclerosis, dysfunctional sleep, an infectious disease, or hemoglobinopathy.

US Pat. No. 10,189,803

SYNTHESIS OF THERAPEUTIC AND DIAGNOSTIC DRUGS CENTERED ON REGIOSELECTIVE AND STEREOSELECTIVE RING OPENING OF AZIRIDINIUM IONS

ILLINOIS INSTITUTE OF TEC...

5. The method of claim 1, further comprising stereoselectively or regioselectively reacting the aziridinium ion with an organometallic compound or a reducing agent comprising hydride.

US Pat. No. 10,189,799

PROCESS FOR PREPARING SUBSTITUTED PHENYLISOXAZOLINE DERIVATIVES

BAYER CROPSCIENCE AKTIENG...

1. Process for preparing one or more phenylisoxazoline derivatives of formula (I)
wherein
R1 is methyl, bromomethyl or chloromethyl;
R2 is halogen, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl and
R3 is C1-C4-alkylsulphonyloxy, C1-C4-haloalkylsulphonyloxy,
wherein, in (i), a chloroxime of formula (II)

wherein R4 is C1-C12-alkyl,
is reacted with a styrene of formula (III)

wherein R2 and R3 are as defined above,
in the presence of an inorganic base in an organic aprotic solvent to give the corresponding phenylisoxazoline of formula (IV)

wherein R2, R3 and R4 are as defined above,
and the latter then reacts, in (ii), with an organometallic reagent and an organic base in an organic aprotic solvent to give the ketone of formula (Ia)

wherein R2 and R3 are as defined above,
and then, in (iii), in the presence of a halogenating agent in a solvent, the haloketone of formula (Ib) is formed

wherein R2 and R3 are as defined above and
X is chlorine or bromine.

US Pat. No. 10,189,796

[4-(1,3,3-TRIMETHYL-2-OXO-3,4-DIHYDRO-1H-QUINOXALIN-7-YL)PHENOXY]ETHYLOXY COMPOUND OR SALT THEREOF

SANTEN PHARMACEUTICAL CO....

1. A compound of general formula (1):
wherein R1 represents a hydrogen atom, a lower alkyl group which may have a substituent(s), a carboxyl group, an ester of a carboxyl group, an amide of a carboxyl group or a cyano group; and
R2 represents a hydrogen atom, a lower alkylcarbonyl group which may have a substituent(s), a lower cycloalkylcarbonyl group which may have a substituent(s), an arylcarbonyl group which may have a substituent(s), a heterocyclic carbonyl group which may have a substituent(s), an ester of a carboxyl group, an amide of a carboxyl group, a phosphate group or an ester of a phosphate group,
or a salt thereof.

US Pat. No. 10,189,794

HETEROARYL COMPOUNDS AND USES THEREOF

Celgene CAR LLC, Pembrok...

1. A method for inhibiting activity of FGFR4, or a mutant thereof, in a patient or biological sample, comprising the step of administering to said patient or biological sample a compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
X1 is —NR4, N, —CR4R4?, or —CR4;
X2 is —NR5, N, —CR5R5?, or —CR5;
X3 is N or CR6
X4 is N or CR7;
X5 is N, C, or CH; wherein at least one of X1, X2, X3, X4, or X5 is N;
G is H, O, OR, or N(R)(R);
Ring A is an optionally substituted group selected from a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 7-10 membered bicyclic saturated, partially unsaturated or aryl ring;
each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 4-7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or
two R groups on the same nitrogen are taken together with the nitrogen atom to which they are attached to form a 4-7 membered heterocyclic ring having 0-2 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 4-7 membered heteroaryl ring having 0-4 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur;
R1 is a warhead group -L-Y; wherein R1 is attached to an atom adjacent to the atom where T is attached, wherein:
orL is a bivalent C2-8 straight or branched, hydrocarbon chain wherein L has at least one double bond and one or two methylene units of L are optionally and independently replaced by —NRC(O)—, —C(O)NR—, —N(R)SO2—, —SO2N(R)—, —S—, —S(O)—, —SO2—, —OC(O)—, —C(O)O—, cyclopropylene, —O—, —N(R)—, or —C(O)—; or
L is a bivalent C2-8 straight or branched, hydrocarbon chain wherein L has at least one alkylidenyl double bond and at least one methylene unit of L is replaced by —C(O)—, —NRC(O)—, —C(O)NR—, —N(R)SO2—, —SO2N(R)—, —S—, —S(O)—, —SO2—, —OC(O)—, or —C(O)O—, and one additional methylene unit of L is optionally replaced by cyclopropylene, —O—, —N(R)—, or —C(O)—; or
L is a bivalent C2-8 straight or branched, hydrocarbon chain wherein one methylene unit of L is replaced by cyclopropylene and one additional methylene unit of L is replaced by —NRC(O)—, —C(O)NR—, —N(R)SO2—, —SO2N(R)—, —S—, —S(O)—, —SO2—, —OC(O)—, or —C(O)O—; or
L is a bivalent C2-8 straight or branched, hydrocarbon chain wherein L has at least one triple bond and one or two methylene units of L are optionally and independently replaced by —NRC(O)—, —C(O)NR—, —N(R)SO2—, —SO2N(R)—, —S—, —S(O)—, —SO2—, —OC(O)—, or —C(O)O—; and
the Y group of R1 is hydrogen, C1-6 aliphatic optionally substituted with oxo, halogen, NO2, or CN, or a 3-10 membered monocyclic or bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein said ring is substituted with 1-4 Re groups; or
L is a covalent bond, —CH2—, —NH—, —C(O)—, —CH2NH—, —NHCH2—, —NHC(O)—, —NHC(O)CH2OC(O)—, —CH2NHC(O)—, —NHSO2—, —NHSO2CH2—, or —SO2NH—, and the Y group of R1 is selected from:
(i) C1-6 alkyl substituted with oxo, halogen, NO2, or CN; or
(ii) C2-6 alkenyl substituted with oxo, halogen, NO2, or CN; or
(iii) C2-6 alkynyl optionally substituted with oxo, halogen, NO2, or CN; or
(iv) a saturated 3-4 membered heterocyclic ring having 1 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-2 Re groups; or
(v) a saturated 5-6 membered heterocyclic ring having 1-2 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-4 Re groups; or
(vi)

 or
(vii) a saturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 Re groups; or
(viii) a partially unsaturated 3-6 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
(ix) a partially unsaturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 Re groups; or
(x)

 or
(xi) a partially unsaturated 4-6 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
(xii)

 or
(xiii) a 6-membered aromatic ring having 0-2 nitrogens wherein said ring is substituted with 1-4 Re groups; or
(xiv)

 or
(xv) a 5-membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-3 Re groups; or
(xvi)

 or
(xvii) an 8-10 membered bicyclic, saturated 3-4 membered heterocyclic, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
L is a covalent bond, —C(O)—, —N(R)C(O)—, or a bivalent C1-8 saturated or unsaturated, straight or branched, hydrocarbon chain; and the Y group of R1 is selected from:
(i) C1-6 alkyl substituted with oxo, halogen, NO2, or CN; or
(ii) C2-6 alkenyl optionally substituted with oxo, halogen, NO2, or CN; or
(iii) C2-6 alkynyl optionally substituted with oxo, halogen, NO2, or CN; or
(iv) a saturated 3-4 membered heterocyclic ring having 1 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-2 Re groups; or
(v) a saturated 5-6 membered heterocyclic ring having 1-2 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-4 Re groups; or
(vi)

 or
(vii) a saturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 Re groups; or
(viii) a partially unsaturated 3-6 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
(ix) a partially unsaturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 Re groups; or
(x)

 or
(xi) a partially unsaturated 4-6 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
(xii)

 or
(xiii) a 6-membered aromatic ring having 0-2 nitrogens wherein said ring is substituted with 1-4 Re groups; or
(xiv)

 or
(xv) a 5-membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-3 Re groups; or
(xvi)

 or
(xvii) an 8-10 membered bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups;
each Re is independently selected from -Q-Z, oxo, NO2, halogen, CN, C1-6 aliphatic optionally substituted with oxo, halogen, NO2, or CN, or a suitable leaving group selected from alkoxy, sulphonyloxy, optionally substituted alkylsulphonyloxy, optionally substituted alkenylsulfonyloxy, optionally substituted arylsulfonyloxy, acyl, or diazonium, wherein:
Q is a bivalent C1-6 saturated or unsaturated, straight or branched, hydrocarbon chain, wherein one or two methylene units of Q are optionally and independently replaced by —N(R)—, —S—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —SO—, —SO2—, —N(R)C(O)—, —C(O)N(R)—, —N(R)SO2—, or —SO2N(R)—; and
each Z is independently hydrogen or C1-6 aliphatic substituted with oxo, halogen, NO2, or CN;
each R2 is independently —R, halogen, -haloalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
R3 is hydrogen, C2-6 alkenyl, —W-Cy, or C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1-3 groups independently selected from halogen, —CN, oxo, —OR?, or —C(O)O(C1-6 alkyl);
W is absent or is a bivalent C1-3 alkylene chain optionally substituted with one or more R? and
wherein one methylene unit of W is optionally replaced with —O—, —S—, or —NR?—;
each R? is independently hydrogen or C1-6 alkyl;
each R? is independently halogen or C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1-3 groups independently selected from halogen, —CN, oxo, or —OR?;
Cy is phenyl, C3-7 cycloalkyl, or a 3-7 membered monocyclic or 5-10 membered bicyclic saturated, partially unsaturated, or heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein Cy is optionally substituted with 1-3 Rx;
each Rx is independently H, —CN, oxo, —NH2, C1-6 alkyl, halogen, —OR?, —N(R?)2, —NHC(O)(C1-6 alkyl), —C(O)N(R?)2, —C(O)O(C1-6 alkyl), —NHSO2(C1-6 alkyl), or —SO2N(R?)2;
or R3 is absent if not allowed by valence;
each of R4 and R4? is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-8 membered saturated or partially unsaturated carbocyclic ring which is optionally bridged, a 4-7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 7-10 membered bicyclic saturated, partially unsaturated or aryl ring, which is optionally bridged;
each of R5 and R5? is independently —R, halogen, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
Y is O or NRa?;
Ra is hydrogen or an optionally substituted C1-6 aliphatic group;
T is a covalent bond or a bivalent straight or branched, saturated or unsaturated C1-6 hydrocarbon chain wherein one or more methylene units are optionally replaced by —O—, —S—, —N(R)—, —C(O)—, —OC(O)—, —C(O)O—, —C(O)N(R)—, —N(R)C(O)—, —N(R)C(O)N(R)—, —S(O)—, —SO2—, —SO2N(R)—, —N(R)SO2—, or —N(R)SO2N(R)—;
q is 0-6; and
each of R6 and R7 is independently —R, halogen, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2.

US Pat. No. 10,189,791

PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE

Trustees of Dartmouth Col...

1. A triterpenoid compound having the structure of Formula I, or a hydrate, stereoisomer, prodrug or pharmaceutically acceptable salt thereof:
wherein one or more of R1, R2 or R3 is independently a substituted or unsubstituted carboxamide group and the remaining R groups are hydrogen.

US Pat. No. 10,189,790

IMIDAZOLINE COMPOUND, MOBILITY CONTROL SYSTEM, PLUGGING AGENT FOR GAS CHANNELING, AND METHOD FOR CARBON DIOXIDE FLOODING

China University of Geosc...

1. A mobility control system comprising the imidazoline compound represented by formula (1), a mobility control additive, and water;wherein R is pentadecyl, and the mobility control additive is sodium p-toluene sulfonate.

US Pat. No. 10,189,789

PROCESS FOR THE PREPARATION OF ANDROGEN RECEPTOR ANTAGONISTS AND INTERMEDIATES THEREOF

Orion Corporation, Espoo...

1. A method for preparing 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile of formula (V)comprising the steps ofa) reacting 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole of formula (I)
with 4-bromo-2-chlorobenzonitrile of formula (II)at an elevated temperature in the presence of Pd(OAc)2, triphenylphosphine and a base in an acetonitrile-water solvent to form 2-chloro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile of formula (III)
b) treating the compound of formula (III) with a catalytic amount of HCl in a methanol solvent;
c) adding a base to neutralize the mixture; and
d) isolating the compound of formula (V).

US Pat. No. 10,189,788

SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS

BAYER PHARMA AKTIENGESELL...

1. A compound of the formula (I)
in which
RA is hydrogen, halogen, pentafluorosulfanyl, cyano, nitro, (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy, amino or a group of the formula —NH—C(?O)—R6, —NH—C(?O)—NH—R6 or —S(?O)n—R7, where (C1-C4)-alkyl and (C1-C4)-alkoxy may be up to trisubstituted by fluorine,
and in which
R6 is hydrogen or (C1-C4)-alkoxy which may be up to trisubstituted by fluorine,
R7 is (C1-C4)-alkyl which may be substituted by hydroxyl, methoxy or ethoxy or up to trisubstituted by fluorine,
and
n is the number 0, 1 or 2,
D is C-RD or N,
E is C-RE or N,
G is C-RG or N,
where not more than two of the ring members D, E and G at the same time are N,
and in which
RD and RE are each independently hydrogen, fluorine, chlorine, methyl, trifluoromethyl, methoxy or trifluoromethoxy,
and
RG is hydrogen, fluorine, chlorine, bromine, methyl or trifluoromethyl,
Z is OH or a group of the formula —NH—R8, —NH—SO2—R9 or —NH—SO2—NR10AR10B, in which
R8 is hydrogen or (C1-C4)-alkoxy which may be up to trisubstituted by fluorine,
R9 is (C1-C4)-alkoxy which may be up to trisubstituted by fluorine, or phenyl,
and
R10A and R10B are each independently hydrogen or (C1-C4)-alkyl which may be up to trisubstituted by fluorine,
R1 is halogen, trifluoromethoxy, (trifluoromethyl)sulfanyl, pentafluorosulfanyl, (C1-C4)-alkyl, trimethylsilyl, cyclopropyl or cyclobutyl,
where (C1-C4)-alkyl may be up to trisubstituted by fluorine
and
cyclopropyl and cyclobutyl may be up to disubstituted by fluorine,
R2, R3 and R4 are each independently hydrogen, fluorine, chlorine, methyl or trifluoromethyl,
R5 is (C1-C4)-alkyl which may be up to trisubstituted by fluorine, or is fluorine, chlorine, methoxy or cyclopropyl,
and
Ar is phenyl which may be mono- or disubstituted identically or differently by fluorine and chlorine, or is pyridyl or thienyl,
and the N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts thereof.

US Pat. No. 10,189,787

INHIBITORS OF HISTONE DEMETHYLASES

Gilead Sciences, Inc., F...

1. A compound of Formula (I)whereinA is —CH2C(O)—;
Y is —NR6R7; p1 R1 is —H;
Z is selected from a single bond, C1-4 alkylene, heterocyclylene and C3-6 cycloalkylene;
each R4 is independently selected from C1-6 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C3-10 cycloalkyl, —N(R10)2, carbamoyl, and —OH;
each R5 is independently selected from C1-6 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C3-6 cycloalkyl, —CN, —F, —Cl, —Br, carbamoyl and —OH;
each of R6 and R7 is independently selected from —H, C1-8 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C2-8 alkenyl, C2-8 alkynyl, C3-10 cycloalkyl, —Z-heterocyclyl, —Z-heteroaryl and —Z-aryl, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, heteroaryl and aryl may optionally be substituted with one or more independently selected R8;
each R8 is independently selected from C1-6 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, —Z-heterocyclyl, —Z-heteroaryl, —Z-aryl, —Z—NR10R11, —Z—C(?O)—NR10R11, —Z—OR9, halogen, —CN, —Z—SR9, —Z—SOR9, —Z—SO2R9 and —Z—COOR9, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, heteroaryl and aryl may optionally be substituted with one or more selected from C1-4 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C3-6 cycloalkyl, —Z-heterocyclyl, —Z-heteroaryl, —Z-aryl, —Z—NR10R11,—Z—C(?O)—NR10R11,—Z—OR9, halogen, —CN, —Z—SR9, —Z—SOR9, —Z—SO2R9 and —Z—COOR9; wherein any heterocyclyl may be further substituted with one or more R4 as defined above, and wherein any heteroaryl and any aryl may be further substituted with one or more R5 as defined above;
each R9 is independently selected from —H, C1-8 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C2-8 alkenyl, C2-8 alkynyl, C3-10 cycloalkyl, —Z-heterocyclyl, —Z-aryl, and —Z— heteroaryl, wherein any heterocyclyl may be substituted with one or more R4 as defined above, and wherein any heteroaryl and any aryl may be substituted with one or more R5 as defined above; and
each of R10 and R11 is independently selected from —H, C1-6 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C2-8 alkenyl, C2-8 alkynyl, C3-10 cycloalkyl, heterocyclyl, heteroaryl, and aryl, wherein any heterocyclyl may be substituted with one or more R4 as defined above, and wherein any heteroaryl and any aryl may be substituted with one or more R5 as defined above;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,786

ANTIBACTERIAL COMPOUNDS

DUKE UNIVERSITY, Durham,...

1. A compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein
X1 represents —CH2—, —(CH2)2—, —(CH2)3—, —CH?CH—, —CH?CHCH2—, —CH2CH?CH—, —C(O)NH—, or —C(O)NH—CH2—;
X2 represents CH2 or NR13;
Y1 represents phenyl optionally substituted with R14, or thiophenyl optionally substituted with R14;
Z1 represents phenyl optionally substituted with R15, or thiophenyl optionally substituted with R15;
R12 is hydrogen, C1-C6 alkyl optionally substituted with R16, or thiophenyl optionally substituted with R16;
and

 moiety is of formula:

wherein
R13 is hydrogen or C1-C6 alkyl;
each R14 is independently selected from the group consisting of halogen, —NO2, —CN, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, and C1-C6 haloalkoxy;
each R15 is independently selected from the group consisting of halogen, —NO2, —CN, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, and C1-C6 haloalkoxy;
each R16 is independently selected from the group consisting of halogen, —NO2, —CN, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, C1-C6 haloalkoxy, aryl, aryl(C1-C6 alkyl), heteroaryl, heteroaryl(C1-C6 alkyl), heterocyclyl, and heterocyclyl(C1-C6 alkyl), wherein each alkyl, aryl, heteroaryl, or heterocyclyl moiety is optionally substituted with one or more R11;
R18 is independently selected from the group consisting of —CONH2, —CON(C1-C6 alkyl), —CON(C1-C6 alkyl)2, —CONH—OH, —CONH—NH2, —CO2H, and —CO2(C1-C6 alkyl);
R19 is hydrogen or C1-C6 alkyl;
R27 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, C1-C6 haloalkoxy, —SH, —S(C1-C6 alkyl), hydroxy(C1-C6 alkyl), alkoxy(C1-C6 alkyl), amino(C1-C6 alkyl), —NHCO(C1-C6 alkyl), —NHCONH2, —NHCONH(C1-C6 alkyl), —OCO(C1-C6 alkyl), and —NHCO(C1-C6 alkoxy);
R28 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, C1-C6 haloalkoxy, —SH, —S(C1-C6 alkyl), hydroxy(C1-C6 alkyl), alkoxy(C1-C6 alkyl), and amino(C1-C6 alkyl);
R29 is C1-C6 alkyl or C1-C6 haloalkyl; and
each R11 is independently selected from the group consisting of halogen, —NO2,—CN, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, and C1-C6 haloalkoxy.

US Pat. No. 10,189,785

HETEROCYCLIC COMPOUND

Takeda Pharmaceuticals Co...

1. A compound represented by a formula:
wherein
ring Ar represents an optionally further substituted aromatic heterocycle or an optionally further substituted C6-14 aromatic hydrocarbon ring;
ring A represents an optionally further substituted C6-14 aromatic hydrocarbon ring or an optionally further substituted heterocycle;
R1 represents an optionally substituted C6-14 aryl group, an optionally substituted C3-10 cycloalkyl group or an optionally substituted heterocyclic group
except that when R1 is an optionally substituted heterocyclic group, R1 is represented by a formula:

wherein ring B represents an optionally further substituted heterocycle, and
[Formula 3]

represents a single bond or a double bond, or a formula:

wherein ring D represents an optionally further substituted nitrogen-containing heterocycle,
R2 represents a hydrogen atom, or
R1 and R2 are bonded to each other to form an optionally substituted 5- or 6-membered aromatic heterocycle or an optionally substituted benzene ring
or a salt thereof.

US Pat. No. 10,189,784

N-(5-((ARYL OR HETEROARYL)METHYLOXY)PENTYL)-SUBSTITUTED IMINOSUGARS AS INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE

ACADEMISCH MEDISCH CENTRU...

1. A compound of general structure I or Ia:
wherein:
each of R19-R26 is independently selected from H, F, Me or Et;
R27 and R28 is independently selected from the group consisting of H, F, CF3 and C1-C8 linear or branched alkyl;
X is:

wherein
Y1-Y5 are independently selected from the group of C and N-atoms provided that not more than two of Y1-Y5 are a N-atom, and provided that if one or two of Y1-Y5 is a N-atom, the R-group attached to that N-atom is void;
Y6-Y9 are independently selected from the group of C-, S-, N- and O-atoms and comprise at least one of an S-, N- or O-atom, provided that Y6-Y9 comprises at most one S-atom, at most one N-atom and/or at most one O-atom, and provided that if one of Y6-Y9 is a S- or
O-atom, the R-group attached to any S-, N- and/or O-atom is void, and provided that if none of Y6-Y9 is a S- or O-atom, the R-group attached to any N-atom is selected from the group consisting of H, C1-C8 linear or branched alkyl, IV and V, and provided that O and S-atoms are not concomitantly present;
one of R1-R9 is

and the remaining of R1-R9 are independently selected from the group consisting of H, F, Cl, Br, I, CN, CF3, C1-C8 linear or branched alkyl and C1-C8 linear or branched oxyalkyl;
wherein
Y10-Y14 are independently selected from the group of C- and N-atoms provided that not more than two of Y10-Y14 are a N-atom, and provided that if one or two of Y10-Y14 is a N-atom, the R-group attached to that N-atom is void;
Y15-Y18 are independently selected from the group of C-, S-, N- and O-atoms and Y19 is selected from the group consisting of a C-atom and a N-atom, provided that Y15-Y19 comprises at most one S-atom, at most one N-atom and/or at most one O-atom, provided that if one of Y15-Y19 is a S- or O-atom, the group attached to any S-, N and/or O-atom is void, and provided that if none of Y15-Y19 is a S- or O-atom, the group attached to any N-atom is selected from the group consisting of H or C1-C8 linear or branched alkyl, and provided that O and S-atoms are not concomitantly present;
R10-R18 are independently selected from the group consisting of H, F, Cl, Br, I, CN, CF3, C1-C8 linear or branched alkyl or C1-C8 linear or branched oxyalkyl, and/or wherein two of R10-R18 form a linear or branched fused alkylene or alkylenedioxy ring on two adjacent atoms of Y10-Y18;
or a pharmaceutically acceptable salt, ester, hydrate, and/or solvate thereof.

US Pat. No. 10,189,783

POLYFUNCTIONAL COMPOUNDS

DSM IP ASSETS B.V., Heer...

1. An imide compound according to any one of formulas Ia, Ib, Ic, Id or Ie:
wherein R1 is H, methyl, hydroxymethyl, 1-hydroxyethyl, isopropyl, sec-butyl, 2-methyl-propyl, 2(methylthio)ethyl, benzyl, tolyl, parahydroxytolyl, or an organic fragment of an amino acid selected from the group consisting of arginine, histidine, lysine, aspartic acid, glutamic acid, serine, threonine, asparagine, glutamine, cysteine, selenocysteine, glycine, proline, alanine, valine, isoleucine, methionine, phenylalanine, tyrosine and tryptophan;
both R2 and R5 are a COOH group or one of R2 and R5 is a COOH group while another of R2 and R5 is H, methyl or an ethyl group;
R3 and R4 are independently H or a C1-C20 hydrocarbon group;
R6 is H or a methyl group; and
R7 and R8 are independently H, methyl or ethyl.

US Pat. No. 10,189,782

DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES

BIOKINESIS, Paris (FR) C...

1. A compound of formula (I):
wherein:
X represents a nitrogen atom, or a N+-O— unit;
R1 and R1? are such that one is H and the other represents a halogen or one —NR11R12 unit wherein R11 and R12 represent H or a (C1-C6)alkyl group;
R2 represents:
a radical (C1-C6)alkoxy, (C3-C6)cycloalkoxy, aryloxy, (C1-C6)alkyl-aryloxy, said radical being optionally substituted with halogen, or a radical thio-(C1-C6)alkyl, thio-aryl, or thio-(C1-C6)alkyl-aryl, said radical being optionally substituted with halogen or a (C1-C6)alkoxy group;
a —NR4R5 unit, a O—(C1-C6)alkyl-NR4R5 unit or a S—(C1-C6)alkyl-NR4R5 unit wherein R4 and R5 represent II or a (C1-C6)alkyl group, with the proviso that at least one among R4 and R5 is not H;
a NHCOR6 unit wherein R6 represents (C1-C6)alkyl group;
an aryl group, optionally substituted with a halogen, a trifluoromethyl group, or a (C1-C3)alkoxy group; or
a halogen;
and
R3 represents a hydrogen, a (C1-C3)alkyl group, a (C1-C3)alkoxy group or a halogen;
and the compounds of formula (I), in which the nitrogen atom of the indole core is substituted by a group selected from the group consisting of a COR7 and a CO2R7 group, wherein R7 represents:
a (C1-C6)alkyl group, optionally substituted by at least a hydroxy group, a (C1-C6)alkyloxy group, a (C1-C6)npolyalkyloxy group wherein n is 1 a (C1-C6)alkyl group;
an aryl or a (C1-C6)alkylaryl;
a —NR9R10 unit wherein R9 and R10 represent a hydrogen or a (C1-C6)alkyl group;
a NH—NR9R10 unit wherein R9 and R10 are as defined above;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,781

ONIUM SALT AND COMPOSITION COMPRISING THE SAME

ASAHI KASEI E-MATERIALS C...

1. A composition comprising:an onium salt comprising a compound A represented by the general formula (1):

wherein R1 and R2 each represent a group selected from the group consisting of hydrogen, an alkyl group, a hydroxy group, a carboxyl group, an alkoxy group, an aryloxy group, an alkylcarbonyl group, an arylcarbonyl group, an aralkylcarbonyl group, an alkoxycarbonyl group , an aryloxycarbonyl group, an alkyl group, an aralkyl group, an aryloxycarbonyl-group, an aralkyloxycarbonyl group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, an alkoxycarbonyloxy group, an aryloxycarbonyloxy group, an aralkyloxycarbonyloxy group, an arylthiocarbonyl group, an arylthio group, an alkylthio group, an aryl group, a heterocyclic hydrocarbon group, an alkylsulfmyl group, an arylsulfmyl group, an alkylsulfonyl group, an arylsulfonyl group, a hydroxy(poly)alkyleneoxy group, an optionally substituted amino group, a cyano group, and a nitro group, and are the same or different from each other;
R3, R4, and R5 each represent a group selected from the group consisting of an aryloxy group, an arylcarbonyl group, an aralkylcarbonyl group, an aryloxycarbonyl group, an aralkyl group, an aralkyloxycarbonyl group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, an aryloxycarbonyloxy group, an aralkyloxycarbonyloxy group, an arylthiocarbonyl group, an arylthio group, an aryl group, an alkylsulfmyl group, an arylsulfinyl group, and an arylsulfonyl group;
X is sulfur;
n represents an integer of 0 to 3;
m represents an integer of 1 to 4;
n and m satisfy n+m<4; and
R6 represents an atomic group capable of forming a monovalent anion; and
wherein the R6 is one group selected from the group consisting of SbY6?, PY6?, AsY6?, BY4?, and CY3SO3? (wherein Y represents at least one selected from the group consisting of a hydrogen atom, an alkyl group, Cl, Br, and I), or is represented by the following general formula (3):

wherein each Y? represents a hydrogen atom, a halogen atom, or an alkyl group, and at least one of the Y? is a halogen atom;
an onium salt comprising a compound B represented by the general formula (2):
wherein R7 and R8 each represent a group selected from the group consisting of hydrogen, an alkyl group, a hydroxy group, a carboxyl group, an alkoxy group, an aryloxy group, an alkylcarbonyl group, an arylcarbonyl group, an aralkylcarbonyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, an aralkyl group, an aralkyloxycarbonyl group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, an alkoxycarbonyloxy group, an aryloxycarbonyloxy group, an aralkyloxycarbonyloxy group, an arylthiocarbonyl group, an arylthio group, an alkylthio group, an aryl group, a heterocyclic hydrocarbon group, an alkylsulfinyl group, an arylsulfinyl group, an alkylsulfonyl group, an arylsulfonyl group, a hydroxy(poly)alkyleneoxy group, an optionally substituted amino group, a cyano group, and a nitro group, and are the same or different from each other;R9 represents a group selected from the group consisting of an aryloxy group, an arylcarbonyl group, an aralkylcarbonyl group, an aryloxycarbonyl group, an aralkyl group, an aralkyloxycarbonyl group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, an aryloxycarbonyloxy group, an aralkyloxycarbonyloxy group, an arylthiocarbonyl group, an arylthio group, an aryl group, an alkylsulfinyl group, an arylsulfinyl group, and an arylsulfonyl group;
R10 represents an atomic group capable of forming a monovalent anion; andwherein the R10 is one group selected from the group consisting of SbY6?, PY6?, AsY6?, BY4?, and CY3SO3? (wherein the Y represents at least one selected from the group consisting of a hydrogen atom, an alkyl group, Cl, Br, and I), or is represented by the following general formula (3):
wherein each Y? represents a hydrogen atom, a halogen atom, or an alkyl group, and at least one of the Y? is a halogen atom.

US Pat. No. 10,189,780

BICYCLIC ALKYL COMPOUNDS AND SYNTHESIS

1. A compound having the structure of Formula (I):
wherein:
R1 is N3, SCN, NO, —C(?NOR2)(CN), or —CH(?NOR2), and
R2 is (C1 to C10) alkoxy, substituted or unsubstituted (C1 to C30) alkyl, substituted or unsubstituted aryl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkynyl, substituted or unsubstituted heterocycle, substituted or unsubstituted heteroaryl, substituted or unsubstituted aryl(alkyl), substituted or unsubstituted alkyl(aryl), or substituted or unsubstituted heteroaryl(alkyl).

US Pat. No. 10,189,777

BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF ROR? AND THE TREATMENT OF DISEASE

Lycera Corporation, Ann ...

1. A compound represented by Formula I:
or a pharmaceutically acceptable salt thereof; wherein:
A is phenylene, 5-6 membered heteroarylene, or C3-6 heterocycloalkylene;
R1 represents independently for each occurrence halogen, C1-6 alkyl, C1-6 haloalkyl, or C3-6 cycloalkyl;
R2 is C1-6 alkyl optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, hydroxyl, and C1-6 alkoxy;
R3 is C1-6 haloalkyl;
R4 represents independently for each occurrence hydrogen, C1-6 alkyl, or C3-6 cycloalkyl;
X is one of the following:
(i) —O-aralkyl, —O-heteroaralkyl, —O-phenyl, —O-heteroaryl, —O-(partially unsaturated bicyclic carbocyclyl), —O—(C1-6 alkylene)—(C3-6 cycloalkyl), —O—(C3-6 cycloalkyl), —N(R4)-aralkyl, —N(R4)-phenyl, —N(R4)-(partially unsaturated bicyclic carbocyclyl), or —N(R4)—(C 1-6 alkylene)—(C3-6 cycloalkyl), each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, and cyano;
(ii) —(C2-6 alkenylene)-phenyl, —(C2-6 alkenylene)-heteroaryl, —(C1-6 alkylene)-phenyl, —(C1-6 alkylene)-heteroaryl, —(C1-6 alkylene)-(partially unsaturated bicyclic heterocyclyl), —(C1-6 alkylene)-(partially unsaturated bicyclic oxo-heterocyclyl), -(5-6 membered heterocycloalkylene)-phenyl, or —(C3-6 cycloalkylene)-phenyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, and cyano; or
(iii) —(C1-6 alkylene)-Z1 or —(C2-6 alkenylene)-Z1, wherein Z1 is —O-aralkyl, —O-heteroaralkyl, —O-phenyl, —O-heteroaryl, —O-(partially unsaturated bicyclic carbocyclyl), —O—(C1-6 alkylene)—(C3-6 cycloalkyl), —O—(C3-6 cycloalkyl), —N(R4)-aralkyl, —N(R4)-phenyl, —N(R4)-(partially unsaturated bicyclic carbocyclyl), —N(R4)—(C1-6 alkylene)—(C3-6 cycloalkyl), or —N(R4)—(C3-6 cycloalkyl), each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, and cyano;
m is 0, 1, or 2; and
n is 1, 2, or 3.

US Pat. No. 10,189,776

STEREOSELECTIVE PROCESS

Boehringer Ingelheim Inte...

1. A method for the preparation of a compound of formula (IV),
wherein
R1a is NC—;
R1b is H, CH3S—, Br, CH3SO2—;
A is NC—;
B is CH3;
or A and B together with the carbon atoms to which they are attached form a ring selected from the group consisting of cyclopentenone, cyclohexenone and furanone;
R2 is F3C—;
R4 is

characterised in that the method comprises step (C), where step (C) is the stereoselective reaction of a compound of formula (I)

with a compound of formula (III)

wherein A, B, R1a, R1b, R2 and R4 have the meanings as defined above;
in the presence of an organo-catalyst of formula (X)

wherein
R3 is selected from the group consisting of

US Pat. No. 10,189,775

CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS

GLENMARK PHARMACEUTICALS ...

1. A compound of formula (I)or a tautomer thereof, stereoisomer thereof or pharmaceutically acceptable salt thereof,whereinR1 is selected from amino, hydroxyl, C1-8alkyl and C1-8alkoxy;
R2 is selected from C1-8alkyl, haloC1-8alkyl, hydroxyC1-8alkyl, C3-6cycloalkyl and C3-6cycloalkylC1-8alkyl;
R3 is selected from hydrogen, C1-8alkyl, haloC1-8alkyl and hydroxyC1-8alkyl;
R4 is selected from C1-8alkyl, C1-8alkoxy, haloC1-8alkyl, hydroxyC1-8alkyl, C3-6cycloalkyl and C3-6cycloalkylC1-8alkyl;
each occurrence of R5 is independently selected from halogen, hydroxyl, cyano, C1-8alkyl, C1-8alkoxy, haloC1-8alkyl, haloC1-8alkoxy, hydroxyC1-8alkyl, C3-6cycloalkyl and optionally substituted C6-14aryl, wherein the substitution on C6-14aryl is halogen;
each occurrence of R6 is independently selected from halogen, cyano, hydroxyl, C1-8alkyl and C3-6cycloalkyl;
Ra and Rb , which may be same or different, are each independently selected from hydrogen and C1-8alkyl; or Ra and Rb together may form an oxo group;
‘n’ is 1, 2, 3 or 4;
‘m’ is 0, 1 or 2; and
‘p’ is 0 or 1.

US Pat. No. 10,189,774

HIGH PENETRATION PRODRUG COMPOSITIONS OF MUSTARDS AND MUSTARD-RELATED COMPOUNDS

Techfields Pharma Co., Lt...

1. A compound chosen from:N,N-diethylaminoethyl 4-[bis(2-chloroethyl)amino]benzenebutyrate.HA; anddiethylaminoethyl 4-[bis(2-methylsulfonylethyl)amino]benzenebutyrate.HA,wherein HA is selected from hydrochloric acid, hydrobromic acid, hydroiodic acid, nitric acid, sulfic acid, bisulfic acid, phosphoric acid, phosphorous acid, phosphonic acid, isonicotinic acid, acetic acid, lactic acid, salicylic acid, citric acid, tartaric acid, pantothenic acid, bitartaric acid, ascorbic acid, succinic acid, maleic acid, gentisinic acid, fumaric acid, gluconic acid, glucaronic acid, saccharic acid, formic acid, benzoic acid, glutamic acid, methanesulfonic acid, ethanesulfonic acid, benzensulfonic acid, p-toluenesulfonic acid and pamoic acid.

US Pat. No. 10,189,771

ACRYLIC ADHESIVE COMPOSITION FROM PROTECTED PHOTOCROSSLINKING AGENTS

3M Innovative Properties ...

1. A protected photocrosslinker of the formula:
wherein
R1 is H or CH3;
each of X1 and X2 is —O— or —NR1—;
R2 is a divalent (hetero)hydrocarbyl group;
subscript a is 0 or 1;
Prot is a carbonyl protecting group;
R3 is selected from:

wherein each R4 is H or a C1 to C6 alkyl group, R5 is independently a hydroxyl group, a phenyl group, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group.

US Pat. No. 10,189,765

PROCESS FOR THE PREPARATION OF 17?-HYDROXY-DES-A-ANDROST-9,10-EN-5-ONE

INDUSTRIALE CHIMICA S.R.L...

1. A process for the synthesis of 17?-hydroxy-des-A-androst-9,10-en-5-one, compound (1), comprising the following steps:a) reaction of compound (4aR,6aS,9aS,9bS)-decahydro-6a-methyl-cyclopenta[f][1]benzopyran-3,7-dione, compound (II), with ethylmagnesium bromide or ethylmagnesium chloride to give the mixture of isomers (4S,5R,7aS)-5-hydroxy-7a-methyl-4-(3-oxopentyl)octahydro-1H-inden-1-one and (4S,5S,7aS)-5-hydroxy-7a-methyl-4-(3-oxopentyl)octahydro-1H-inden-1-one, intermediate mixture (III):

b) oxidation of the intermediate mixture (III) to give (4S,7aS)-7a-methyl-4-(3-oxopentyl)hexahydro-1H-inden-1,5(4H)-dione, intermediate (IV):

c) cyclization of the intermediate (IV) to give des-A-androst-9,10-en-5,17-dione, intermediate (V):

d) reduction of the intermediate (V) to 17?-hydroxy-des-A-androst-9,10-en-5-one, compound (1):

US Pat. No. 10,189,763

REDUCTION OF GREENHOUSE GAS EMISSION

RES USA, LLC, Westminste...

1. A method of reducing greenhouse gas (GHG) emission comprising: introducing one or more gaseous carbonaceous feed streams into a reformer to generate synthesis gas, wherein said reformer comprises hydrogen membrane tubes, manifolded and supported from the top of the reformer above the fluidized bed; uses no process steam and requires no oxygen; and converting synthesis gas to dimethyl ether (DME).

US Pat. No. 10,189,761

METHOD FOR POLYOL SYNTHESIS FROM TRIACYLGLYCERIDE OILS

1. A method for the preparation of polyols from an unsaturated triacylglycerol (TAG) oil comprising the steps of:(a) fully or partially epoxidizing the unsaturated TAG oil to obtain an epoxidized TAG oil;
(b) transesterifying the epoxidized TAG oil using a diol and/or triol in the presence of a catalyst and a solvent, to produce a hydroxyalkyl esters of fatty acid epoxides; and
(c) hydroxylating the transesterification product using a diol and/or triol and a catalyst to obtain a polyol.

US Pat. No. 10,189,759

PROCESS FOR PREPARING A CHLORINATED ALKENE

SPOLEK PRO CHEMICKOU A HU...

1. A process for preparing a chlorinated alkene comprising:contacting a chlorinated alkane with a catalyst comprising metallic iron, ferrous chloride, ferric chloride, or any combination thereof, in a dehydrochlorination zone to produce a reaction mixture comprising the catalyst, the chlorinated alkane and the chlorinated alkene,
contacting the reaction mixture with an aqueous medium and an acid in an aqueous treatment zone thereby forming a biphasic mixture comprising an aqueous phase and an organic phase, and
extracting chlorinated alkene from the organic phase of the biphasic mixture, wherein the concentration of the chlorinated alkene in the reaction mixture present in the dehydrochlorination zone is controlled such that the molar ratio of chlorinated alkene:chlorinated alkane is from 1:99 to 50:50, and wherein the process is performed under reaction conditions that enable the chlorinated alkene to be produced selectively with other isomer formation less than 5% based on sum of all alkene isomers produced.

US Pat. No. 10,189,755

OLIGOMERIZATION OF ETHENE IN SUPERCRITICAL MODE

Evonik Degussa GmbH, Ess...

1. A process for oligomerizing ethene, comprising:(I) an oligomerization operation, in which a mixture comprising ethene and an inert medium contacts a solid catalyst, wherein the proportion by weight of the inert medium in the mixture is greater than the proportion by weight of ethene in the mixture, wherein the inert medium is a C3-C7 alkane or a C3-C7 cycloalkane, wherein the pressure and temperature of the mixture are chosen with respect to the proportion by weight of ethene in the mixture such that the ethene and the inert medium are in the supercritical state, and wherein the ethene and the inert medium each contact the solid catalyst in the supercritical state; and
(II) a regeneration operation, in which the solid catalyst in the absence of ethene, hydrogen, and oxygen is purged with a liquid purge medium, wherein:
a) operation is interchanged over time between the oligomerization operation and the regeneration operation, in such a way that a time-limited oligomerization operation is followed by a time-limited regeneration operation, and the latter in turn is followed by a time-limited oligomerization operation;
b) the solid catalyst is always at the same location during both the oligomerization operation and the regeneration operation;
c) the location of the solid catalyst is supplied with positive or negative thermal energy in order to impose a set temperature thereon during both the oligomerization operation and the regeneration operation;
d) the set temperature in the regeneration operation is lower than the set temperature in the oligomerization operation; and
e) the pressure at the location of the solid catalyst is lower in the regeneration operation than in the oligomerization operation.

US Pat. No. 10,189,754

BUTADIENE PRODUCTION SYSTEM AND BUTADIENE PRODUCTION METHOD

SEKISUI CHEMICAL CO., LTD...

1. A butadiene production system, comprising:a gas preparation device that heats raw materials to prepare a mixed gas comprising hydrogen and carbon monoxide;
an ethanol production device that is provided downstream of the gas preparation device and brings the mixed gas into contact with a catalyst (X) to obtain ethanol;
a butadiene production device that is provided downstream of the ethanol production device and brings the ethanol into contact with a catalyst (Y) different from the catalyst (X) to obtain butadiene; and
a return means for returning hydrogen, which is produced as a by-product in the butadiene production device, to the ethanol production device.

US Pat. No. 10,189,753

FOG-GENERATING DEVICE COMPRISING A REAGENT AND IGNITION MEANS

Bandit NV, Opglabbeek (B...

1. A fog-generating device comprisinga reservoir comprising a movable wall and a fog-generating material,
a heat exchanger; and
means for driving said movable wall to expel the fog-generating material from the reservoir to the heat exchanger.

US Pat. No. 10,189,752

MOISTURE BARRIER COATINGS

SURFACE CHEMISTS OF FLORI...

13. A method of producing a controlled release fertilizer comprising the steps of:i. providing a quantity of fertilizer particles;
ii. heating the fertilizer particles to a temperature above the melting point of the organic wax;
iii. providing one or more moisture barrier coatings, at least one of said moisture barrier coatings comprising:
a. at least one organic wax
b. at least one wax soluble polymer wherein the wax soluble polymer is at least one selected from the group consisting of ethylene-vinyl acetate copolymers and terpolymers, modified polyolefins, acrylate ester polymers and copolymers, and tackifying resins;
c. a thermoset polymerwherein the weight ratio of organic wax to wax soluble polymer is from about 50:50 to about 98:2 and wherein the weight ratio of thermoset polymer to combined organic wax and wax soluble polymer is from about 50:50 to about 98:2;iv. mixing the organic wax and wax soluble polymer to provide a mixture
v. dispersing the mixture into at least one component of the thermoset polymer to provide a dispersion;
vi. applying the dispersion to the fertilizer particles while providing mixing sufficient to spread the dispersion as a coating on the fertilizer particles, and
vii. curing the thermoset polymer on the surface of the particles to form free flowing coated granules.

US Pat. No. 10,189,751

FLUID IONIZED COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF

BI-EN CORP., Portland, O...

1. A method of enhancing plant growth, comprising:applying quantum harmonic resonance to a sprayable fluid composition to modulate the electron spin of elements within the composition, wherein the sprayable fluid composition comprises:
mixture of about 40 to 20 parts of dissolved acid or acid-formed approximately neutral pH nitrogen plant nutrient compounds and about 1 to about 5 parts of a mixture of insoluble or weakly soluble calcium-formed plant nutrient compounds,
wherein the dissolved acid comprises nitric acid, phosphoric acid, a weak carbonic acid or a combination thereof and the acid-formed nitrogen plant nutrient compounds are in solution and comprise fluid urea ammonium nitrate (UAN), ammonium nitrate, calcium ammonium nitrate, ammonium phosphate, aqueous ammonia or combinations thereof; and
the insoluble or weakly soluble calcium-formed plant nutrient compounds are in solution and comprise H2O and lime nitrogen; and then
applying an effective amount of the sprayable fluid composition to soil prior to, during and/or after planting, thereby enhancing plant growth.

US Pat. No. 10,189,747

REFRACTORY METAL SILICIDE NANOPARTICLE CERAMICS

The United States of Amer...

1. A composition comprising:nanoparticles comprising a refractory-metal silicide; and
a carbonaceous matrix;
wherein the carbonaceous matrix comprises graphitic carbon or amorphous carbon;
wherein the composition is not in the form of a powder.

US Pat. No. 10,189,744

USE OF AN EPOXIDE-AMINE-BASED MULTICOMPONENT MORTAR COMPOSITION

Hilti Aktiengesellschaft,...

1. A multicomponent mortar composition comprising a hybrid hardener which contains a mixture of(i) at least one amine, selected from among aliphatic, alicyclic and aromatic amines, wherein the amine on average has at least two reactive hydrogen atoms, bonded to a nitrogen atom, per molecule, as a hardener;
(ii) a novolac resin of formula (I):

in which R1, R2, R3 and R4, each independent of each other, are hydrogen or an unbranched or branched C1-C15 alkyl radical and n is 1 to 12, wherein the novolac resin is contained in a quantity of 30 to 45 percent by weight, relative to the total weight of the hybrid hardener (i) and (ii), as a catalyst; and
(iii) a compound of formula (II):

in which R1 is hydrogen or an unbranched or branched C1-C15 alkyl radical, R2 is a (CH2)nNR5R6 radical or a NH(CH2)nNR5R6 radical, in which R5 and R6 independently of each other are an unbranched or branched C1-C15 alkyl radical and n is 0 or 1, R3 and R4 independently of each other are hydrogen or a (CH2)nNR7R8 radical or a NH(CH2)nNR7R8 radical, and R7 and R8 independently of each other are an unbranched or branched C1-C15 alkyl radical and n is 0 or 1,
wherein the multicomponent mortar composition is epoxide-based, and
wherein the multicomponent mortar composition chemically fastens structural elements and anchoring means.

US Pat. No. 10,189,743

ENHANCED STRENGTHENING OF GLASS

APPLE INC., Cupertino, C...

1. A method for strengthening a piece of glass, said method comprising:enhancing the piece of glass by placing the piece of glass in a first sodium solution for a first period of time to migrate sodium ions into the piece of glass; and
following the enhancing, chemically strengthening the piece of glass by placing the piece of glass in a potassium solution for a second period of time to exchange potassium ions for sodium ions in the piece of glass, the first period of time being less than the second period of time;
following the chemically strengthening, back exchanging the piece of glass by placing the piece of glass in a second sodium solution for a third period of time to back exchange sodium ions for potassium ions to move a compressive maximum inward approximately 70 microns from an outer edge of the piece of glass; and
following the back exchanging, post-processing the piece of glass by polishing the piece of glass, wherein:
the piece of glass is a cover glass for a portable electronic device; and
the piece of glass has a thickness of less than 1.0 mm.

US Pat. No. 10,189,741

HIGH STRENGTH GLASS-CERAMICS HAVING PETALITE AND LITHIUM SILICATE STRUCTURES

CORNING INCORPORATED, Co...

19. A glass-ceramic article comprising:Li2O;
SiO2;
Al2O3; and
grains having, as measured by a scanning electron microscope, a longest dimension of 100 nm or less as measured and an aspect ratio of 2 or greater,
wherein the article is transparent and has a transmittance of at least 85% for light in a wavelength range from 400 nm to 1,000 nm at a thickness of 1 mm.

US Pat. No. 10,189,740

OPTICAL GLASS, PREFORM, AND OPTICAL ELEMENT

OHARA INC., Kanagawa (JP...

1. An optical glass comprising, in mol %,40.00 to 65.0% of an SiO2 component,
1.0 to 9.03% of an Nb2O5 component,
1.0 to 35.0% of an Na2O component,
less than 9.0% of a ZrO2 component, and
less than 2.5% of a CaO component,
and having
a refractive index (nd) of 1.62 to 1.75,
an Abbe number (?d) of 30 to 42, and
a partial dispersion ratio (?g,F) of no greater than 0.594.

US Pat. No. 10,189,737

FIBER OPTIC MANUFACTURING IN SPACE

FOMS Inc., San Diego, CA...

1. A method comprising:forming an optical fiber in a low gravity environment, the optical fiber formed with a primary coating;
causing the optical fiber to be returned to a terrestrial environment; and
forming a secondary coating on the optical fiber in the terrestrial environment.

US Pat. No. 10,189,736

METHOD OF MANUFACTURING A GLASS ROLL

NIPPON ELECTRIC GLASS CO....

1. A method of manufacturing a glass roll, comprising:forming, while conveying a glass film to a downstream side, the glass film by a forming device for carrying out a downdraw method;
rolling the glass film while superposing a first protective film on the glass film at a downstream end of a path of the conveying in the forming, to thereby manufacture a source glass roll;
unrolling, while conveying the glass film to the downstream side, the glass film from the source glass roll; and
rerolling the glass film while superposing a second protective film on the glass film at a downstream end of a path of the conveying in the unrolling to thereby manufacture a glass roll,
wherein, in the forming, the glass film at the downstream side of the forming device is conveyed while only a first surface of the glass film is contact-supported,
wherein, in the unrolling, the glass film at the downstream side of the source glass roll is conveyed while only the first surface of the glass film is contact-supported,
wherein, in the unrolling, a plurality of rollers is arranged on a conveying path from the source glass roll to the glass roll and contact-supports only the first surface of the glass film, the rollers changing a direction of conveying the glass film so that the glass film is bent toward the first surface side thereof, and wherein a wrap angle of the glass film relative to each of the rollers to the glass film is an acute angle, and wherein tension in a rerolling direction to be applied to the glass film in the rerolling is set higher than tension in the rolling direction to be applied to the glass film in the rolling.

US Pat. No. 10,189,734

FLOATING METHANATION SYSTEM

1. An apparatus for treatment and transformation of municipal wastewater sludge or other organic putrescible matter into biogas and liquid fertilizer by anaerobic digestion, said apparatus comprising a plurality of floating bioreactors consecutively arranged in series; wherein a first bioreactor initially processes wastewater sludge or other organic putrescible matter also wherein to remove sand, gravel or crushed glass; a series of middle bioreactors which process and digest the wastewater sludge or putrescible matter and a final bioreactor wherein the sludge or matter is further digested; wherein the final bioreactor includes means for measuring and monitoring the end of biogas production; said apparatus further comprising a heat exchanger for heating the sludge or matter for the destruction of harmful bacteria and pathogens; wherein each bioreactor comprising a longitudinal body to digest and provide methanation reaction of said sludge or matter within the bioreactor; each of said bioreactors further comprising a longitudinal inlet end, an inlet spout, located at a middle point of said longitudinal inlet end, connected to an inlet conduit by an inlet elbow, for purpose of receiving the matter into the bioreactor; said bioreactors further comprising a longitudinal outlet end, an outlet spout located at a middle point of said longitudinal outlet end, connected to an outlet conduit by an exhaust elbow for the purpose of exiting the matter from one bioreactor to the next bioreactor and from the last bioreactor at the end of the process, wherein pressure is created by retaining the biogas produced and wherein said floating bioreactors are almost totally immersed in warm water in a thermally insulated basin to maintain predetermined temperature for digestion and methanation conditions; wherein said bioreactors revolve on themselves by air ejected from a conduit disposed underneath said bioreactors, wherein said air is pumped into said conduits by air diaphragm pumps activated by the pressurized biogas; said air lodging in rotation buckets aligned as circular saw teeth outside the longitudinal body of the bioreactor, said air provoking a rotating action, mixing the contents; each of said bioreactors include mixing buckets aligned inside the body of the bioreactor; each of said bioreactors further comprise flotation rings located at the inlet and outlet of the bioreactor for counterbalancing the weight of the bioreactors and to provide buoyancy to the bioreactors so that the bioreactors remain horizontally disposed while floating; said apparatus further comprising a primary inlet pump, which is a dual hydraulic command diaphragm pump having a dual purpose, first to initiate and supply initial matter to be processed, and secondly, to drive said matter through the heat exchanger and squeeze the pressure created by heat against a first swivelling valve exhaust pump, said first swivelling valve exhaust pump working in combination with a last swivelling valve exhaust pump, both being two-diaphragm pumps having two functions: first to retain, control, and release the flow and pressure by transferring power hydraulically to the primary inlet pump, while the second function in which they differ, is that the first swivelling valve exhaust pump creates a vise action from the high pressure created from heating matter in the heat exchanger situated between said primary inlet pump and said first swivelling valve exhaust pump while the last swivelling valve exhaust pump retains the working pressure of the entire apparatus and transfers said pressure to the primary inlet pump from a closed-center hydraulic circuit that increases said pressure by the action of gas hydraulic pumps from each bioreactor, said closed-center hydraulic circuit comprising a shut-off valve that commands the last swivelling valve exhaust pump to operate and let consumed matter to escape when production of biogas is over, and a shut-off valve that commands the primary inlet pump to operate when new material is needed; said apparatus further comprising biogas pipes for the capture of biogas from the inside top portion of each bioreactor; wherein each of said bioreactors include a pressure relief valve to control the pressure in each bioreactor; said apparatus further including a plurality of hoses and conduits for the purpose of transporting fluids out of the bioreactor for the removal of fertilizers, juices and salts.

US Pat. No. 10,189,731

UNDERGROUND SEPTIC TANK

Pallette Stone Corporatio...

1. An underground septic tank comprising:a substantially liquid impermeable, cylindrical plastic vessel having a top, a bottom, sides, and a substantially horizontal longitudinal axis;
a concrete container encasing and retaining the cylindrical plastic vessel, the concrete container contacting the bottom and at least partially contacting the sides of the cylindrical plastic vessel; and
at least one opening for receiving waste effluent into the cylindrical plastic vessel;
wherein the septic tank is adapted to withstand vehicle loading.

US Pat. No. 10,189,729

METHOD AND APPARATUS FOR PREVENTING MOLD GROWTH IN THE RESERVOIR OF A FOOD WASTE RECYCLING APPLIANCE

Whirlpool Corporation, B...

1. A food waste recycling appliance comprising:a housing defining an interior;
a recycling chamber located within the interior and configured to receive organic material for recycling;
a reducing mechanism provided within the recycling chamber and configured to mix the organic material with air;
a container configured to receive the recycled organic material from the recycling chamber;
a condensate reservoir located within the interior of the housing and fluidly coupled to the recycling chamber; and
a plurality of biocidal agents disposed in the condensate reservoir, each of the plurality of biocidal agents having a plurality of filaments intertwined with each other to form a matrix in three dimensions, wherein each of the plurality of filaments comprises a surface of exposed copper.

US Pat. No. 10,189,727

FLUID PURIFICATION METHODS, DEVICES, AND SYSTEMS

NxStage Medical, Inc., L...

1. A water purification system, comprising:a plurality of cells, each cell of the plurality of cells including a water purification element;
a valving network including valves and fluid conduits fluidly interconnecting said plurality of cells; and
a controller connected to the valving network to permit the controller to operate said valves,
wherein the valving network further includes
a source water inlet,
a drain outlet, and
a product water outlet,
wherein the valving network is configurable by the controller, by operation of the valves, to form selected interconnections between and among selected ones of the cells to define a flow channel from a selected one of
the source water inlet,
the drain outlet, and
the product water outlet,
through said selected ones of said cells, to a selected other of said selected one of
the source water inlet,
the drain outlet, and
the product water outlet,
wherein the controller is configured to, during a first time period, open and close valves of the valving network
to define a first continuous flow channel from the source water inlet, through a first filtering group of two or more of the cells in series to the product water outlet, and
to define a second continuous flow channel from the product water outlet through a first regenerating group of one or more of the cells to the drain outlet, whereby the first filtering group filters water to produce product water while the first regenerating group is regenerated by a portion of the product water flowing through the one or more of the cells of the first regenerating group in a reversed flow direction,
wherein the controller is further configured to, during a second time period, open and close the valves of the valving network
to define a third continuous flow channel from the source water inlet through a second filtering group of two or more of the cells in series to the product water outlet, and
to define a fourth continuous flow channel from the product water outlet through a second regenerating group of one or more of the cells to the drain outlet, whereby the second filtering group filters water to produce the product water while the second regenerating group of one or more of the cells is regenerated by a portion of the product water flowing through the one or more of the cells of the second regenerating group in the reversed flow direction,
wherein the first and second time periods are at different times, the second filtering group of two or more of the cells is different from the first filtering group of two or more of the cells, and the second regenerating group of one or more of the cells is different from the first regenerating group of one or more of the cells,
wherein a first cell of the first filtering group receives water directly from the source water inlet and a second cell of the first filtering group receives water directly from the first cell,
wherein the first cell of the first filtering group is included in the second regenerating group of one or more of the cells and the second cell of the first filtering group receives water directly from the source water inlet during the second time period, and
the cells are electronic deionization cells.

US Pat. No. 10,189,726

ELECTROCHEMICAL DESALINATION FOR OIL RECOVERY

Evoqua Water Technologies...

1. A method for improved oil recovery, comprising:introducing seawater to an electrically-driven separation system comprising a first electrodialysis apparatus including monovalent selective membranes and a second electrodialysis apparatus including divalent selective membranes;
measuring at least one parameter of the seawater selected from the group consisting of composition, total dissolved solids concentration, sulfate concentration, and hardness, at an inlet of the electrically-driven separation system;
selectively passing a first portion of the seawater through the first electrodialysis apparatus and a second portion of the seawater through the second electrodialysis apparatus for treatment based on the measured parameter to produce first and second product streams, respectively, such that the first product stream has a greater concentration of hardness than the second product stream;
blending the first and second product streams to produce treated water including less than about 200 mg/l of sulfate, having a total dissolved solids (TDS) content in the range of about 1000 mg/l to about 5000 mg/l, and having a hardness level in the range of about 100 ppm to about 1000 ppm without blending or remineralizing the treated water with a source of hardness; and
flooding at least a portion of an oil reservoir with the treated water.

US Pat. No. 10,189,725

METHODS OF SEPARATING IMPURITIES FROM INDUSTRIAL MINERALS USING ELECTROCOAGULATION

1. A method of purifying an industrial mineral composition, the method comprising:obtaining or providing an aqueous slurry comprising a mineral composition, the mineral composition comprising one or more industrial minerals and one or more impurities, the one or more industrial minerals comprising at least one of akaogiite alunite, anatase, asbestos, barite, bentonite, borate, brookite, calcium carbonate, carbonatite, chromite, corundum, diamond, diatomite, feldspar, nepheline, syenite, fluorspar, fuller's earth, garnet, gem minerals, granite, graphite, gypsum, kaolin, kyanite, sillimanite, andalusite, limestone, dolomite, marble, mica, olivine, perlite, phosphate, potash-potassium minerals, pumice, quartz, rutile, salt, slate, silica, tripoli, trona, sodium sulfate, nahcolite, mirabilite, staurolite, sulfur, talc, vermiculite, wollastonite, and zeolite:
subjecting the aqueous slurry to an electrical current to form at least one coagulation comprising the one or more impurities; and
separating at least one of the coagulations from the one or more minerals to provide a purified mineral composition.

US Pat. No. 10,189,723

MULTI-MEDIA STRATIFIED FILTRATION

SIEMENS ENERGY, INC., Or...

1. A system for treating a feed stream comprising hydrocarbons and an aqueous-based liquid, the system comprising:a vessel comprising a feed stream inlet fluidly connected with the feed stream and a treated stream outlet fluidly connected with a treated stream; and
a filter bed positioned within the vessel and comprising a first layer of filter media disposed on a second layer of filter media,
wherein at least the first layer comprises a plurality of composite media particles, each of the plurality of composite media particles comprising a mixture of a cellulose-based material and a polymer, and
wherein the filter media of the first layer comprises a lower density than that of the second layer.

US Pat. No. 10,189,722

PRESSURIZED GAS LIFTING AND GAS REJUVENATION

1. A method comprising:providing a vessel having
an inlet for receiving pressurizing gas,
an inlet for receiving wastewater to be accumulated in the vessel, and
an exit port having an intake opening within the vessel, where wastewater and the pressurizing gas may flow from the intake opening within the vessel and into a wastewater infiltration system;
flowing wastewater into the vessel, the wastewater accumulating in the vessel;
flowing pressurizing gas into the vessel above a top surface of the accumulating wastewater in the vessel, the pressurizing gas developing a pressure above wastewater in the vessel; and
flowing a dose of wastewater upwards from the intake opening and then flowing a dose of the gas upwards from the intake opening and out of the exit port of the vessel, the dose of the gas flowing out of the exit port after the dose of wastewater, and the wastewater and the gas each flowing towards the wastewater infiltration system,
wherein pressurized gas flowing from the inlet into the vessel does not flow out of the exit port when the level of wastewater flowing into the vessel is above the intake opening.

US Pat. No. 10,189,721

SYSTEM AND METHOD FOR USING AC AND DC SENSORS FOR WATER TREATMENT

Griswold Water Systems, ...

1. A method, implemented by a computer including a suitably programmed microprocessor, for automatically operating water treatment equipment including a high voltage resonance circuit, an analog-to-digital converter, and one or more coils for use in water treatment, the method comprising the steps of:determining, using the microprocessor, whether a coil is an alternating current (AC) coil or a direct current (DC) coil by detecting whether a capacitor is connected in series with the coil, wherein if the capacitor is connected in series the coil is determined to be an AC coil;
initiating by applying current and initiating a timer;
reading an AC threshold from a memory and issuing an alarm if a measured AC voltage is less than the AC threshold;
reading a minimum current from the memory and issuing an alarm if a measured DC current does not meet the minimum current;
issuing commands to one or more driver processors to control frequency of pulses of the one or more coils to approximately reach and maintain a resonant frequency of the pulses for water treatment; and
using one or more sensors to measure a quality of water for water being treated and provide feedback to the microprocessor.

US Pat. No. 10,189,720

WATER PURIFYING CARTRIDGE AND PITCHER-TYPE WATER PURIFIER

Mitsubishi Rayon Cleansui...

1. A water purifying cartridge, comprising:a water purification material for treating water to be treated;
a housing body in which the water purification material is directly received, a discharge hole discharging purified water is formed at a bottom, and a top end is opened;
a plate-shaped housing lid provided at the top end of the housing body, and
a film filtration water purification unit and an adsorption water purification unit,
wherein the adsorption water purification unit is disposed at an upstream side of the film filtration water purification unit, and the adsorption water purification unit is configured by an adsorbing material that is directly filled in the housing body, and
wherein the film filtration water purification unit is a hollow fiber film water purification unit.

US Pat. No. 10,189,719

PROCESS FOR THE MANUFACTURE OF LITHIUM METAL OXIDE CATHODE MATERIALS

Nano One Materials Corp.,...

1. A process for forming a precursor to a lithium metal oxide comprising:providing lithium bicarbonate in a first aqueous mixture;
reacting said lithium bicarbonate with metal acetate thereby forming a second aqueous mixture comprising metal carbonate, lithium acetate, acetic acid and water;
neutralizing said acetic acid in said second aqueous mixture with lithium hydroxide thereby forming a third mixture comprising metal carbonate and lithium acetate;
separating said third mixture into a fourth mixture and a fifth mixture wherein said fourth mixture comprises said metal carbonate and a first portion of said lithium acetate with said metal carbonate and said lithium acetate being in a predetermined molar ratio, and said fifth mixture comprises a second portion of said lithium acetate; and
drying said fourth mixture thereby forming said precursor comprising metal carbonate and lithium acetate in said predetermined molar ratio.

US Pat. No. 10,189,718

METHODS FOR CHARGE-TITRATING PARTICLE ASSEMBLY, AND STRUCTURES PRODUCED THEREFROM

HRL Laboratories, LLC, M...

1. A method of assembling a plurality of particles into a particle array, said method comprising:dispersing a plurality of first particles in a volume of liquid solution, wherein said first particles are characterized by an average zeta potential, and wherein said liquid solution is characterized by a starting pH;
introducing to said liquid solution before, during, or after said first particles are dispersed in said liquid solution, a triggerable pH-control substance capable of generating an acid or a base when triggered; and
triggering said pH-control substance to generate an acid or a base within said volume of liquid solution, thereby adjusting solution pH from said starting pH to a titrated pH, wherein said average zeta potential is closer to zero at said titrated pH compared to said starting pH, causing said first particles to assemble into a particle array.

US Pat. No. 10,189,717

SYNTHESIS OF ALUMINOSILICATE ZEOLITE SSZ-26 VIA INTERZEOLITE TRANSFORMATION


US Pat. No. 10,189,715

ULTRAHARD STISHOVITE NANOPARTICLES AND METHODS OF MANUFACTURE

Lehigh University, Bethl...

1. A method of preparing nanosized single crystals (nanocrystals) of stishovite silica, the method consisting of:heating a cubic mesoporous silica starting material under a pressure ranging from 10 GPa to 20 GPa to a temperature ranging from 300° C. to 400° C.; and
cooling the material to room temperature;thereby preparing nanocrystals of stishovite silica having an average particle size of between 200 nm and 800 nm.

US Pat. No. 10,189,714

OPERATION OF FLUIDIZED BED REACTORS BY OPTIMIZING TEMPERATURE GRADIENTS VIA PARTICLE SIZE DISTRIBUTION CONTROL

Corner Star Limited, Hon...

1. A method of controlling the axial temperature gradient of a polysilicon fluidized bed reactor having a distributor plate and a core bed, the method comprising:adding polysilicon seeds having a pre-determined particle size distribution into the core bed of the fluidized bed reactor;
measuring the width of the particle size distribution of granules in the bed, wherein the granules consist of a mixture of newly added seeds and previously added seeds, the previously added seeds having grown and/or shrunk in size;
adjusting the frequency of seed addition into the reactor to change the width of the particle size distribution of the granules in the bed such that the temperature in the fluidized bed reactor is from about 1000° F. to about 1300° F. when the granules are at a normalized height of from about 0.4 to about 1.0 in the core bed;
depositing silicon from a thermally decomposable compound onto the previously added and newly added seeds; and
withdrawing a polysilicon product from the bed.

US Pat. No. 10,189,712

OXIDATION OF POROUS, CARBON-CONTAINING MATERIALS USING FUEL AND OXIDIZING AGENT

International Business Ma...

18. A method comprising:passing a first pressurized air stream through a fuel source to saturate the first pressurized air stream with fuel vapor and form a saturated air stream;
combining the saturated air stream with a second pressurized air stream to form a third pressurized air stream;
exposing a microporous, carbon-containing material to the third pressurized air stream and an oxidizing agent to allow the microporous, carbon-containing material to adsorb at least some of the fuel vapor; and
while continuing to expose the microporous, carbon-containing material to the third pressurized air stream and the oxidizing agent, heating the microporous, carbon-containing material to a temperature at which combustion of the fuel vapor occurs to combust the adsorbed fuel vapor to seal pores of the microporous, carbon-containing material adjacent to its surface.

US Pat. No. 10,189,710

METHOD OF PURIFYING PHOSPHORIC ACID

TENOVA ADVANCED TECHNOLOG...

1. A method of purifying phosphoric acid comprising:(a) providing a pre-treated wet phosphoric acid feed containing:
(i) 2-62% phosphoric acid, expressed as a percent weight of P2O5 in said feed;
(ii) a sulfate concentration of at least 15 ppm, per each 1 percent weight of said P2O5 in said feed; and
(iii) metallic impurities including iron, aluminum, calcium, magnesium, and chromium, a total feed concentration of said iron, aluminum, calcium, magnesium, and chromium being at least 10 ppm, per each 1 percent weight of said P2O5 in said feed;
(b) subjecting said pre-treated wet phosphoric acid feed to a first nanofilter in at least a first nanofiltration stage, to obtain a first permeate and a first reject;
(c) treating said first permeate to produce sulfate solids in a partially treated phosphoric acid stream;
(d) removing at least a portion of said solids from said phosphoric acid stream to produce a sulfate-depleted phosphoric acid stream; and
(e) subjecting said sulfate-depleted phosphoric acid stream to at least a second nanofilter in at least one additional nanofiltration stage, to obtain a purified phosphoric acid in a second permeate, and a second reject, said second permeate containing:
(i) a concentration of 2-62% phosphoric acid, expressed as a percent weight of P2O5 in said second permeate;
(ii) a sulfate concentration of less than 10 ppm per each 1 percent weight of said P2O5 in said second permeate; and
(iii) metallic impurities including iron, aluminum, calcium, magnesium, and chromium, a total concentration of said iron, aluminum, calcium, magnesium, and chromium in said second permeate being at most 5 ppm, per each 1 percent weight of said P2O5 in said second permeate.

US Pat. No. 10,189,708

RUTHENIUM ON CHITOSAN (CHRU): CONCERTED CATALYSIS FOR WATER SPLITTING AND REDUCTION

The United States of Amer...

1. A process for generating hydrogen and oxygen from water, the process comprising preparing a ruthenium on chitosan catalyst, bringing the catalyst into contact with an aqueous mixture under basic conditions, and applying microwave energy to the aqueous mixture to produce hydrogen and oxygen.

US Pat. No. 10,189,707

EMBEDDED STRUCTURES FOR HIGH GLASS STRENGTH AND ROBUST PACKAGING

Continental Automotive Sy...

1. A method for making a pressure sensor, comprising the steps of:providing a first wafer; and
providing a second wafer;
forming at least one angled recess as part of the first wafer;
forming at least one upper recess as part of the second wafer;
forming at least one lower recess as part of the second wafer;
bonding the first wafer to the second wafer to form a wafer stack having at least one saw street area, such that the at least one angled recess, the at least one upper recess, and the at least one lower recess are partially located in the saw street area;
partitioning the wafer stack in the saw street area to form at least two pressure sensors.

US Pat. No. 10,189,706

METHOD FOR SELF-ALIGNING SOLDER-ATTACHED MEMS DIE TO A MOUNTING SURFACE

DunAn Microstaq, Inc., A...

1. A method of attaching a MEMS die to a surface, the method comprising:placing solder mask having a centrally formed flow area on a solder surface of a body;
centering and rotationally aligning a solder perform on the solder surface of the body within the flow area of the solder mask;
centering and rotationally aligning a MEMS die on the solder preform; and
heating the solder perform in a reflow process until the solder is molten and surface tension of the molten solder moves the MEMS die to a position where the surface tensions balance and the MEMS die is centered within the flow area of the solder mask;
wherein the solder surface of the body is substantially circular and the solder preform is substantially rectangular.

US Pat. No. 10,189,705

MONOLITHIC INTEGRATION OF MEMS AND IC DEVICES

GLOBALFOUNDRIES SINGAPORE...

1. A device comprising:a substrate having first and second surfaces;
integrated circuit (IC) components disposed on the first surface of the substrate;
a back-end-of-line (BEOL) dielectric with at least one interlevel dielectric (ILD) level with interconnects and contacts coupled to the IC components disposed on the first surface of the substrate;
a pad level on an uppermost ILD level, the pad level comprises IC interconnect pads coupled to the IC components via the at least one ILD level;
a micro electromechanical system (MEMS) stack disposed over the pad level, the MEMS stack includes
a MEMS region having a MEMS component with MEMS electrodes and MEMS contacts coupled to the MEMS electrodes, and
an IC region over the IC interconnect pads, the IC region includes IC MEMS contacts configured to be coupled to the IC interconnect pads; and
a MEMS encapsulation layer disposed over the MEMS stack, including the MEMS and IC regions, the MEMS encapsulation layer comprises a planar top surface, wherein the encapsulation layer comprises MEMS solder bumps in the MEMS region and IC MEMS solder bumps in the IC region.

US Pat. No. 10,189,703

MULTI-CHAMBER TRANSDUCER MODULE, APPARATUS INCLUDING THE MULTI-CHAMBER TRANSDUCER MODULE AND METHOD OF MANUFACTURING THE MULTI-CHAMBER TRANSDUCER MODULE

STMicroelectronics S.r.l....

1. A transducer module, comprising:a supporting substrate having a first side, a second side, and a recess;
a cap coupled to the first side of the supporting substrate to form a first chamber and a second chamber, the second chamber being internally isolated from the first chamber;
a first sensor chip coupled to the first side of the supporting substrate in the first chamber, the first sensor chip integrating a first MEMS transducer configured to detect a first environmental quantity and to generate a first transduced signal as a function of the first environmental quantity detected;
a second sensor chip coupled to the first side of the supporting substrate in the second chamber, the second sensor chip integrating a second MEMS transducer configured to detect a second environmental quantity and to generate a second transduced signal as a function of the second environmental quantity detected; and
a control chip arranged in the recess of the supporting substrate, the control chip including a first surface that is exposed in the first chamber and a second surface that is exposed in the second chamber, the control chip being functionally coupled to the first and second MEMS transducers and configured to receive, in use, the first and the second transduced signals.

US Pat. No. 10,189,702

SEMICONDUCTOR DEVICE AND METHOD OF FORMING MICROELECTROMECHANICAL SYSTEMS (MEMS) PACKAGE

STATS ChipPAC Pte. Ltd., ...

1. A method of making a semiconductor device, comprising:providing a first semiconductor die;
disposing a modular interconnect structure laterally with respect to the first semiconductor die;
depositing an encapsulant around the first semiconductor die and modular interconnect structure;
forming a build-up interconnect structure over the first semiconductor die and modular interconnect structure after depositing the encapsulant, wherein a non-routing area over the first semiconductor die remains devoid of the build-up interconnect structure; and
disposing a second semiconductor die over the first semiconductor die, wherein the first semiconductor die or second semiconductor die includes a microelectromechanical device, wherein an active surface of the first semiconductor die is oriented toward an active surface of the second semiconductor die.

US Pat. No. 10,189,701

SENSOR, FILTER ELEMENT COMPRISING A SENSOR AND USE OF SAID TYPE OF FILTER ELEMENT

CARL FREUDENBERG KG, Wei...

1. A filter element, comprising:a main part; and
a sensor, comprising:
an electronic chip; and
a sensor chip,
wherein the electronic chip and sensor chip are arranged within a functional space which is at most 5 mm long, at most 3 mm wide, and at most 0.8 mm high,
wherein the sensor is arranged on the main part,
wherein the main part includes a filter medium including an upstream side and a downstream side,
wherein the sensor chip is high-resolution such that a pressure differential between the upstream side and the downstream side in a range of from 10 to 500 Pa can be detected, and
wherein the sensor chip has a resolution of 5 Pa.

US Pat. No. 10,189,700

INTEGRATED CIRCUIT (IC) CHIP WITH A SELF-CONTAINED FLUID SENSOR AND METHOD OF MAKING THE CHIP

The United States of Amer...

1. An integrated circuit (IC) chip including a self-contained fluid sensor comprising:a semiconductor substrate;
a non-conductive cap disposed on said semiconductor substrate;
a conduit at the interface between said semiconductor substrate and said nonconductive cap, each end of said conduit passing through said non-conductive cap;
a temperature sensor in said conduit at said each end; and
a heating element in said conduit between the temperature sensors wherein the temperature sensors and said heating element are encased in dielectric; further wherein said non-conductive cap is a pyrex cap with a channel at said semiconductor substrate, wherein said conduit comprises said channel and
wherein said semiconductor substrate comprises a mirco-channel, said conduit further comprises said mirco-channel, the encased temperature sensors and said heating element being suspended in said conduit at said interface.

US Pat. No. 10,189,699

MEMS DEVICE AND MEMS VACUUM MICROPHONE

INFINEON TECHNOLOGIES AG,...

1. A method of reading out a MEMS device, the MEMS device comprising first membrane element, a second membrane element spaced apart from the first membrane element, a low pressure region between the first and second membrane elements, the low pressure region having a pressure less than an ambient pressure, and a counter electrode structure comprising a first conducting layer, which is at least partially arranged in the low pressure region or extends in the low pressure region, wherein the first conducting layer comprises a segmentation providing an electrical isolation between a first portion of the first conducting layer and a second portion of the first conducting layer, the method comprising:providing a signal generated by a deflection of the first membrane element and a deflection of the second membrane element.

US Pat. No. 10,189,697

BIG BOTTLE FORMAT DISPENSER

1. A device comprising: a housing in a form factor of a bottle, the housing defining an outer reservoir; an inner reservoir carried within the housing; wherein the inner reservoir is in a form factor of a molded figurine; wherein the molded figurine is a branding indicator; a window in a front of the housing exposing the inner reservoir; wherein the inner reservoir is filled with an alcoholic beverage; and wherein the outer reservoir is not filled with an alcoholic beverage; wherein the housing further comprises a cap and a base and a mid-section wherein tamper proof seals are located at joints between the mid-section and each of the cap and the base.

US Pat. No. 10,189,696

BOTTLED BAG FLUID DISPENSER

Utrem Innovation, LLC, H...

1. An apparatus for dispensing a beverage comprising:a bottle;
a bladder for containing the beverage; and
a spigot for dispensing the beverage, wherein the spigot comprises:
one or more air ports, wherein each air port comprises a cutout on a wall of the spigot, wherein the one or more air ports are configured to maintain atmospheric pressure inside the bottle; and
one or more vertical ridged elements, wherein the bladder is sealed to a base portion of the spigot, and wherein the one or more ridged elements are configured to create an air gap between the spigot and the bottle to allow air to flow into a body of the bottle.

US Pat. No. 10,189,695

KEG COVER

1. A keg cover for removable joinder to a keg, comprising:a structure adapted for removable joinder to a top rim of the keg, said structure having a top surface and a bottom surface opposite from the top surface, and defining a center;
a depending rim spaced radially apart from the center and extending axially downwardly from the top surface of the structure, said depending rim defining a curved channel adapted to removably engage the top rim of the keg;
at least one notch in the depending rim;
a sidewall section extending axially downwardly from the top surface of the structure at the at least one notch, said sidewall section terminating with a radially outwardly extending tongue; and
at least one tab extending radially outwardly from the depending rim;
wherein the at least one notch is positioned for alignment with a hand grip formed in the top rim of the keg when the structure is joined to the top rim of the keg.

US Pat. No. 10,189,694

YEAST-CREAM-DOSING DEVICE AND METHOD

LESAFFRE ET CIE, Paris (...

23. A device for dosing of stable bakers' yeast cream in a bakery, said device comprising:a piece of furniture provided with a refrigerated compartment having an internal temperature regulated at between ?2° C. and 12° C.;
an interchangeable transport reservoir located in the refrigerated compartment and containing stable yeast cream, said reservoir having a total internal volume of between 1 and 100 liters, and an outlet opening for the yeast cream;
an outlet conduit for dosing of the yeast cream, said conduit connecting the outlet opening of the interchangeable transport reservoir to a dispensing opening outside the refrigerated chamber; and
an opening/closing mechanism for the outlet conduit, enabling the opening of the outlet conduit for the dispensing of the yeast cream and enabling the closure of the outlet conduit in order to stop the dispensing of the yeast cream,
said device permitting the dispensing of a dosed quantity of yeast cream from the interchangeable transport reservoir via the dispensing opening,
wherein said interchangeable transport reservoir is a collapsible bag that permits the dispensing of a dosed quantity of yeast cream via the dispensing opening by activation of the opening/closing mechanism without entry of gas from outside the collapsible bag into the collapsible bag.

US Pat. No. 10,189,693

FILLING ELEMENT AND FILING MACHINE

KHS GmbH, Dortmund (DE)

1. An apparatus for filling containers with liquid filling material, said apparatus comprising a filling element, said filling element comprising a filling-element housing comprising a dispensing opening through which filling material flows into a container and a liquid channel formed in said housing through which filling material flows towards said dispensing opening, and a liquid valve arranged in said liquid channel and disposed to control flow through said liquid channel into said container through said dispensing opening, wherein said liquid valve comprises an elastic diaphragm made of elastic material and a rod having a tapered end, wherein said filling element further comprises an actuator that causes said diaphragm to transition between a first state, in which said diaphragm butts against said tapered end, and a second state, in which said diaphragm is spaced apart from said tapered end, wherein said diaphragm is a hollow structure that is rotationally symmetric in relation to a diaphragm axis thereof, wherein, when said liquid valve opens, said diaphragm forms a continuation of said liquid channel, wherein said diaphragm comprises a funnel-shaped first section that narrows in the direction of said dispensing opening, wherein said diaphragm abuts against said tapered end when said valve is closed, and wherein said abutment occurs as a result of pressure from said actuator.

US Pat. No. 10,189,690

VEHICLE LIFT

Marta Fiorese, Albignase...

1. A vehicle lift including a vehicle support plane (1), a base plate (50), and a lifting/lowering mechanism (101) disposed between said vehicle support plane and said base plate, said lifting/lowering mechanism comprising:two pair of levers (2,3) each arranged laterally supporting said vehicle support plane, the levers (2,3) of each pair being articulated to one another scissor like in an intermediate section (4) defining parallel inner levers (2,2) and parallel outer levers (3,3), the inner levers of each pair each having a first end hingedly connected said vehicle support plane and each having a second end adapted to slide longitudinally on said base plate, the outer levers of each pair each having a first end adapted to slide longitudinally on an underside of said vehicle support plane and each having a second end hingedly connected to said base plate;
an articulated system (10) interconnecting the inner levers of the two pair of levers and including a rocker arm (11) comprising two lateral side wall elements (12) each hingedly connected at an intermediate axis (14) to a respective inner lever of said tow pair of levers, a first roller (20) rotatably supported on an axle pin (22) interconnecting said lateral side wall elements at a first end of said rocker arm, a second roller (21) rotatably supported on an axle pin (23) interconnecting said lateral side wall elements at a second end of said rocker arm, in a collapsed condition of said vehicle lift said first roller (20) engaging for rotation thereon a first inclined plane (30) and said second roller (21) engaging for rotation thereon a second inclined plane (31), said first and second inclined planes being upwardly converging; and
a fluid-dynamic actuator (9) articulated at a first end to a member interconnecting the second ends of the outer levers of the two pair of levers and operatively connected at a second end to said axle pin at the first end of said rocker arm of said articulated system,
whereby upon commencement of lifting and opening the vehicle lift, the fluid-dynamic actuator (9) acts on the articulated system (10) imparting a thrust to the axle pin at the first end of the rocker arm (11) causing the first roller (20) to move upwardly on the respective inclined plane (30) and as a result of the rocker action of the rocker arm (11) an upward movement is imparted to the intermediate axis (14) connecting the rocker arm (11) to the inner levers of the two pair of levers (2,3) resulting in upward movement of the inner levers and commencement of lifting and opening of the vehicle lift and simultaneously the second roller (21) is moved upwardly on the second inclined plane (31).

US Pat. No. 10,189,688

WINCH DRUM WITH INTERNAL WIRE STORAGE

NATIONAL OILWELL VARCO NO...

1. A winch drum device comprising:a first winch drum having a central axis of rotation and a radially outer surface configured to accommodate a plurality of axially displaced turns of wire rope;
an annular recess extending radially inward from the radially outer surface of the first winch drum and extending about the circumference of the radially outer surface of the first winch drum;
wherein the annular recess is configured to accommodate one or more turns of the wire rope and the first winch drum is configured to rotate about the central axis of rotation to pay in and pay out the wire rope from the annular recess.

US Pat. No. 10,189,686

PNEUMATIC AND MANUAL CLUTCH OF POWER WINCH

Comeup Industries Inc., ...

1. A power winch comprising:a motor with a power for driving a deceleration device through an internal axial transmission; and
a plurality of planetary gear sets for driving a cable pulley to rotate after the internal axial transmission;
wherein a cable wound around the cable pulley can be released or retracted, with the deceleration device having a gearbox, an inner ring gear sheathed on an inner side of the gearbox and linked with the deceleration device, with an outer ring surface of the inner ring gear having a plurality of braking grooves, with a top of the gearbox having a through slot corresponsive to the plurality of braking grooves, and a clutch installed on the through slot, with the clutch having a clutch lever, with a bottom of the clutch lever passed through the through slot and configured to be corresponsive to one of the plurality of braking grooves, with the clutch lever being upwardly coupled to a handle, with the handle operated to ascend or descend to link the bottom of the clutch lever to be latched to or released from one of the plurality of braking grooves, to connect or disconnect the internal axial transmission between the deceleration device and the cable pulley, wherein air is pumped into the clutch, wherein the bottom of the clutch lever is lifted pneumatically to release from latching with the one of the plurality of braking grooves, to disconnect the internal axial transmission between the deceleration device and the cable pulley, wherein the clutch has a lower seat and an upper seat, wherein a bottom section of the lower seat is coupled to the through slot of the gearbox, wherein a penetrating slot is formed longitudinally inside the lower seat, wherein a positioning wall is formed and extended from an upper section of the lower seat; wherein the clutch lever is inserted into the penetrating slot of the lower seat, wherein a first ring groove is formed at a lower section of the clutch lever, wherein a first O-ring is provided for enclosing the first ring groove and closely attaching to an inner wall of the penetrating slot, wherein a large disc section is formed after the clutch lever is extended upwardly, wherein a second ring groove is formed around a periphery of the large disc section, wherein a second O-ring is provided for enclosing the second ring groove and is further extended upward, wherein a micro-channel is formed at a peripheral wall at a top section of the clutch lever, wherein a third O-ring is provided for enclosing the micro-channel, wherein a screw groove is inwardly and downwardly formed at the top end of the clutch lever, wherein an elastic member is sheathed on the clutch lever, wherein a bottom end of the elastic member abuts the large disc section; wherein the upper seat is hollowed inwardly, wherein the lower seat is coupled to the positioning wall, wherein when the upper seat is extended upwardly, the upper seat is aligned with the large disc section of the clutch lever, wherein a lower air chamber is formed between the large disc section, the lower seat, the clutch lever and the upper seat, wherein an air inlet passage is formed in a peripheral wall of the upper seat corresponsive to the lower air chamber and extended outside for locking and coupling a pneumatic connector, wherein a penetrating slot is inwardly formed on the upper seat extended upwardly for extending the clutch lever to outside, wherein a top end of the elastic member abuts the upper seat, wherein an upper air chamber is formed between the upper seat and the clutch lever and the large disc section, wherein an air passage is formed on the upper seat, wherein the upper air chamber is communicated to the outside, wherein a silencer is locked and coupled to an outer side of the air passage, wherein a net is coupled to the front end of the silencer; wherein the handle has a through groove inwardly formed at a top of the handle, wherein a bottom covers the upper seat, and wherein an engaging member is passed from top to bottom through the through groove and locked and coupled to the screw groove of the clutch lever.

US Pat. No. 10,189,684

COUNTERWEIGHT ATTACHMENT AND REMOVAL DEVICE AND COMBINATION OF SAME WITH COUNTERWEIGHT

Caterpillar SARL, Geneva...

1. A counterweight attachment and removal device to and from which a counterweight is attached and removed, the counterweight attachment and removal device comprising:a bracket fixed to a rear end of a construction machine;
a link with a base end thereof connected to the bracket;
a link cylinder configured to elevate and lower the link; and
a pair of coupling units disposed at a leading end of the link, wherein each of the pair of coupling units comprises:
a pair of coupling pieces extending from the link and configured to slew around a center axis of the link extending in a width direction and to tilt relative to the center axis, the coupling pieces being disposed at a distance from each other in the width direction; and
a coupling pin removably connected between extension ends of the pair of coupling pieces.

US Pat. No. 10,189,683

MOBILE CRANE WITH BALLAST RECEIVING APPARATUS

Liebherr-Werk Ehingen Gmb...

1. A mobile crane having an undercarriage and a superstructure rotatable with respect to the undercarriage about an axis of rotation and having a ballast receiving apparatus arranged at the superstructure and having at least one ballasting cylinder for receiving a ballast, whereina position of the ballasting cylinder receiving the ballast is variable in the ballast receiving apparatus such that the ballast can be received in positions of different distances from the axis of rotation of the superstructure,
the ballasting cylinder can be fixed in position via a locking mechanism, and
the locking mechanism comprises a spring-loaded pin which can be drawn against a spring force, with the pivoting of the respective ballasting cylinder arranged at a pivot console being able to be carried out from the ground.

US Pat. No. 10,189,682

RESCUE HOOK WITH INTEGRATED LIGHTING

Goodrich Corporation, Ch...

1. A bumper assembly for a rescue hoist, the bumper assembly comprising:a bumper having a barrel extending between a top end and a bottom end;
a top plate disposed on the top end, the top plate defining a compartment configured to house a power source; and
a first lighting element disposed on the bumper and configured to emit light in response to a current from the power source;
wherein the bumper includes at least one recess extending into an outer surface of the bumper, the at least one recess configured to house the first lighting element.

US Pat. No. 10,189,680

LANDING-DOOR DOOR LOCK DEVICE

OTIS ELEVATOR COMPANY, F...

1. A landing-door door lock device, comprising a primary lock and a secondary lock, wherein the primary lock comprises a bottom plate and a locking arm, a counter weight is mounted on the locking arm, a moving ball is fixed onto the counter weight, a fixed ball is mounted on the bottom plate, and the secondary lock comprises a buckle plate, characterized in that: the locking arm (7) is rotationally connected onto the bottom plate (13) through a rotary shaft (8), a rear end of the locking arm is provided with a first kidney-shaped hole (16), the counter weight is fixed with the locking arm through the kidney-shaped hole, an arc-shaped hole (14) is opened on the counter weight, a shaft sleeve (15) is sheathed on a shaft of the fixed ball, the shaft sleeve penetrates into the arc-shaped hole, a second kidney-shaped hole is opened on the bottom plate, the fixed ball is fixed with the bottom plate through the kidney-shaped hole, a front end of the buckle plate is provided with a first lock hook (18), the locking arm is correspondingly provided thereon with a lock column (20), and the first lock hook is buckled on a first lock column.

US Pat. No. 10,189,677

ELEVATOR CONTROL SYSTEM WITH FACIAL RECOGNITION AND AUTHORIZED FLOOR DESTINATION VERIFICATION

Edward A. Bryant, Maplew...

1. A method for controlling an elevator car using facial recognition, comprising the steps of:providing at least one elevator car, the at least one elevator car controlled by an elevator control system;
providing a facial image database comprising facial image data of authorized passengers and corresponding authorized floor destination data for each such passenger;
providing a facial recognition program capable of comparing a facial image stored in the facial image database to video data output from a first imaging device, the facial recognition program in communication with the elevator control system;
providing a first imaging device capable of outputting video data;
detecting an elevator passenger's upturned head and recognizing a facial image of the elevator passenger's face in a field of view of the first imaging device;
capturing the elevator passenger's facial image using video data output from the first imaging device;
comparing the captured facial image to the facial image data;
determining a match between the captured facial image and a facial image stored in the facial image database;
sending a signal to the elevator control system to call the at least one elevator car in a preferred up/down direction; and
sending a signal to the elevator control system to move the at least one elevator car to the elevator passenger's authorized floor destination.

US Pat. No. 10,189,676

APPARATUS FOR PERFORMING A RESCUE RUN IN AN ELEVATOR SYSTEM BY SELECTING RESCUE FUNCTIONS TO UTILIZE TO PERFORM THE RESCUE RUN AND A METHOD OF PERFORMING SAME

Kone Corporation, Helsin...

1. A method for performing a rescue run, the method comprising:receiving information from sensors measuring an operation of an elevator about points being measured with the sensors;
reading, from a non-volatile memory device, rescue run functions that are selectable to perform the rescue run;
automatically selecting one or more of the rescue run functions based on information received from the sensors; and
performing the rescue run including the selected one or more rescue run functions.

US Pat. No. 10,189,675

FULLY ADJUSTABLE BRAKE CONTROLLER WITHOUT NEED OF DC-LINK

Kone Corporation, Helsin...

1. An adjustable brake controller of an elevator brake, comprising:a DC bus;
first terminals for connecting the adjustable brake controller to a first magnetizing coil;
second terminals for connecting the adjustable brake controller to a second magnetizing coil;
a first controllable power switch coupled between the first terminals and the DC bus, the first controllable power switch being configured to supply electric power from the DC bus to the first magnetic coil responsive to a first control signal;
a second controllable power switch coupled between the second terminals and the DC bus, the second controllable power switch being configured to supply electric power from the DC bus to the second magnetizing coil responsive to a second control signal; and
a controller configured to generate the first and the second control signals for controlling the first and second controllable power switches, respectively, the controller having
a brake open mode for opening a brake, wherein the first and second control signals have a same specified pattern, and
a brake holding mode for holding the brake open, wherein the first and second control signals have a different specified pattern.

US Pat. No. 10,189,674

IMAGE FORMING APPARATUS

CANON KABUSHIKI KAISHA, ...

1. An image forming apparatus comprising:an image forming unit configured to form an image on a sheet;
a first discharging portion configured to discharge the sheet on which the image has been formed to an outside of the image forming apparatus;
a first supporting portion configured to support the sheet discharged by the first discharging portion;
an image reading portion configured to read the image formed on the sheet;
a first switching portion configured to switch between a first position to cause the sheet discharged by the first discharging portion to be conveyed to the first supporting portion and a second position to cause the sheet to be conveyed toward the image reading portion configured to read the image;
a second discharging portion configured to discharge the sheet whose image has been read by the image reading portion to the outside of the image forming apparatus;
a second supporting portion configured to support the sheet discharged by the second discharging portion; and
a second switching portion configured to switch between a third position to cause the sheet whose image has been read by the image reading portion to be conveyed toward the second discharging portion and a fourth position to cause the sheet to be conveyed toward the image forming unit,
wherein the image reading portion is disposed above the first discharging portion in a vertical direction.

US Pat. No. 10,189,673

METHOD AND APPARATUS FOR APPLYING LIQUID NUTRIENTS BETWEEN PARALLEL ROWS OF STANDING CROPS

Alig Enviromental Solutio...

1. A method of efficiently applying liquid nutrients to parallel rows of standing crops growing in a field with minimal damage to the crops, the method comprising the steps ofwinding an elongated flexible drag hose onto a power driven hose reel with the drag hose having an inlet and an outlet,
supporting the hose reel with a vehicle for axial movement of the hose reel adjacent a first end of the field and perpendicular to the rows of crops,
connecting the drag hose extending from the hose reel to an elongated substantially rigid boom having an end portion connected to a central portion of an elongated applicator connected to a tractor positioned to move between the rows of standing crops,
pulling the drag hose longitudinally directly from the hose reel with the tractor and between two of the parallel rows of crops and in alignment with the center of the tractor,
pivotally connecting the boom to the applicator with the applicator extending laterally substantially beyond opposite sides of the tractor,
connecting the drag hose to a liquid distribution line of the applicator with the distribution line having outlets located between the rows of crops,
pumping the liquid nutrients from a supply source into the inlet of the drag hose supported by the hose reel,
pulling the drag hose with the tractor directly from the hose reel between the two rows of crops with the hose reel rotating on its axis while the applicator and distribution line supply the liquid nutrients to a first group of at least six of the parallel rows of standing crops,
maintaining the drag hose between the two rows of crops while pulling the drag hose from the reel with the tractor,
turning the tractor and applicator at an opposite second end of the field while the boom and the applicator are elevated above the crops and with the boom pivoting to a continuous supply position projecting outwardly and longitudinally from an end portion of the applicator about one half the length of the applicator and to position the tractor with the applicator extending transversely to a second group of at least six of the parallel rows of crops,
returning the tractor and the applicator to the first end of the field with the boom in the continuous supply position for continuously supplying the liquid nutrients through the drag hose and distribution line to the second group of rows of crops,
maintaining the drag hose between the two rows of crops with the boom and applicator extending transversely from the tractor and with the boom in the continuous supply position projecting from the end portion of the applicator above the crops while rewinding the drag hose directly onto the hose reel,
synchronizing the rewinding of the drag hose onto the hose reel with the returning of the tractor and applicator,
moving the hose reel axially with the vehicle to a third group of at least six rows of crops, and
repeating the above steps to apply the liquid nutrients to the third group of the parallel rows of crops.

US Pat. No. 10,189,672

METHOD FOR PRODUCING AN OPTICAL FIBER COIL, OPTICAL FIBER COIL AND OPTICAL FIBER INTERFEROMETER

IXBLUE, Saint-Germain-en...

1. A method of making a symmetrical-winding coil of optical fiber comprising the following steps:a. symmetrically winding an optical fiber around an axis, the winding starting from a point of the optical fiber located at equal distance from the two ends of the optical fiber, the winding forming a pattern comprising a same number N of layers of each half of the optical fiber, where N is a natural integer, a layer comprising a set of turns of optical fibers and spaces located between adjacent turns, the turns of a layer coming from a same half of the optical fiber and being placed at a same distance from the coil axis, and said winding forming a coil having a sectored arrangement comprising both a regular stacking area in which the turns of optical fiber of a layer are juxtaposed to the turns of the adjacent layer(s), so as to form at least one continuous sealing surface between two layers of adjacent turns, as well as an overlap area in which portions of optical fiber linking different turns of a same layer and/or different layers of the winding cross each other;
b. making a glue infiltrate into the sectored-arrangement coil through an external surface of the overlap area so that the glue infiltrates through at least one continuous path of communication into the spaces located between adjacent turns in the regular stacking area, up to said at least one sealing surface.

US Pat. No. 10,189,671

DEVICE AND METHOD FOR THE SUBSEQUENT PROCESSING OF PRINTED PRODUCTS

Muller Martini Holding AG...

1. A device for processing printed products (4,5) comprising,a transport device (10,12) for transporting printed products (4) along a transport path (100), wherein said transport device includes a plurality of transport members (11,13) arranged behind one another in the transport direction (101) for respectively transporting a printed product (4) to be processed;
a plurality of processing devices (3,6,7,8) that are arranged along the transport path (100) for sequentially modifying the transported printed products (4);
a controller (9) operatively connected to the transport device (10,12) and at least one of the processing devices (3,6,7,8) for mutual communication of control signals;
a lighting system (20) extending along the transport path (100) and operatively connected to the controller (9); wherein
the lighting system (20) is divided into individual lighting segments (21.1,21.n) along the transport path;
each lighting segment (21.1, . . . , 21.n) comprises at least one activatable light source (22); and
each lighting segment (21.1, . . . , 21.n) is operatively connected to the controller (9) for receiving a segment control signal,
wherein the controller (9) monitors the control signals for information on the presence and status of the printed products (4) and in response to said information, generates a control signal to separately activate a light source in each individual lighting segment (21.1, . . . , 21.n) to provide a visual indication of the current status of a printed product (4) in proximity to the activated lighting segment (21.1, . . . , 21.n).

US Pat. No. 10,189,670

PAPER SHEET HANDLING MACHINE AND PAPER SHEET HANDLING METHOD

GLORY LTD., Himeji-shi, ...

1. A sheet handling machine comprising:an inlet unit through which a sheet is inserted from an outside of a housing into an inside thereof;
a transport unit configured to transport the sheet inserted in the inlet unit;
a recognition unit disposed on the transport unit and configured to recognize the sheet being transported by the transport unit;
a storage unit configured to store the sheet recognized by the recognition unit; and
a shifting unit provided in the transport unit, wherein
when the sheet is recognized by the recognition unit as a hybrid sheet having a first portion that includes paper and a second portion that includes predetermined material other than the paper, the shifting unit shifts the hybrid sheet being transported by the transport unit, in a width direction orthogonal to a direction in which the sheet is transported, according to a position, in the width direction, of a specific member in the storage unit.

US Pat. No. 10,189,668

SHEET CUTTING MACHINE

Horizon International Inc...

1. A sheet cutting machine for cutting a first sheet into second sheets and margins, the machine comprising:a first conveying part arranged to convey the first sheet along a conveying path;
a cutting part arranged downstream of and apart from the first conveying part to cut the first sheet in a direction perpendicular to a conveying direction;
a sorting unit arranged to remove the margins from the conveying path, the margins being cut off from the first sheet by the cutting part; and
a control unit configured to control the first conveying part, the cutting part and the sorting unit based on. cutting information about cutting of the first sheet,
the sorting unit including:
a second conveying part arranged downstream of and apart from the cutting part to receive the first sheet from the first conveying part and to convey the second sheets cut off from the first sheet by the cutting part;
a retracting mechanism arranged to upwardly retract the second conveying part from the conveying path; and
a deflecting plate for deflecting the first sheet away from the conveying path while the first sheet is conveyed by the first conveying part, the deflecting plate being moved together with the second conveying part by the retracting mechanism, wherein
when a first length in the conveying, direction of the margin to be cut off is shorter than a predetermined distance between the cutting part and the second conveying part, the first sheet is fed to the cutting part by the first conveying part while the second conveying part is kept positioned at the conveying path, and the margin is cut off from the first sheet by the cutting part, and
when a second length is equal to or longer than. the predetermined distance, the first sheet is fed to the cutting part by the first conveying, part after the second conveying part is retracted from the conveying path by the retracting mechanism, and the margin is cut off from the first sheet by the cutting part, and wherein
the deflecting plate is apart from the conveying path when the second conveying part stays at the conveying path, and
the deflecting plate stays at the conveying path when the second conveying part is apart from the conveying path.