US Pat. No. 10,113,522

END SEAL STRUCTURE OF A FUEL RAIL FOR A GASOLINE DIRECT INJECTION ENGINE

USUI KOKUSAI SANGYO KAISH...

1. An end seal structure of a fuel rail for a gasoline direct injection engine, comprising:a rail body composed of a pipe having a pressing surface formed at least at one end of the rail body and defining a spherical seat surface, and external threads formed on the rail body; and
an end cap that has a cap-nut shape with a closed end, an open end and an inner wall surface extending from the open end to the closed end, internal threads formed in the inner wall surface, and a pressure receiving surface formed on the inner wall surface of the end cap, the pressure receiving surface defining a concave tapered seat surface and being disposed so that the internal threads are between pressure receiving surface and the open end of the end cap; wherein
the end cap is screwed and fixed to the rail body
so that the concave tapered pressure receiving surface of the end cap is brought into pressure contact with the spherical pressing surface of the rail body by an axial force created by tightening the internal threads of the end cap to the external threads of the rail body to seal the end of an opening of the rail body.

US Pat. No. 10,113,513

INTERNAL COMBUSTION ENGINES

HYDRO-JECT, LLC, Wilming...

1. A method of operating an internal combustion engine that comprises a variable volume combustion chamber containing a catalyst, said method comprising:at a first pressure in said combustion chamber, admitting an intake gas comprising an aspirant into said combustion chamber;
reducing the volume of said combustion chamber to compress said intake gas to raise pressure in said combustion chamber from said first pressure to a second pressure that is greater than said first pressure;
admitting an aqueous fluid and a steam reforming fuel into said combustion chamber when the pressure in said combustion chamber reaches a predetermined pressure intermediate said first and second pressures so that said aqueous fluid and steam reforming fuel absorb heat generated by said compression of said intake gas and said catalyst promotes a steam reformation process by which hydrogen is separated from said steam reforming fuel or said aqueous fluid;
when the pressure in said combustion chamber is at least at said second pressure, admitting a combustible fuel into said chamber and combusting said combustible fuel and hydrogen; and
wherein the volume of said combustion chamber is varied by moving a body in said combustion chamber and combustion of said fuel and hydrogen causes movement of said body to increase the volume of said combustion chamber and said movement of said body provides an energy output of said combustion chamber.

US Pat. No. 10,113,492

HYBRID COMBUSTION SYSTEM AND METHOD

Caterpillar Inc., Deerfi...

1. An internal combustion engine, comprising:at least one cylinder case forming a plurality of cylinders, the plurality of cylinders including a first grouping of cylinders and a second grouping of cylinders, each of the plurality of cylinders including a primary fuel injector, a secondary fuel injector and a spark device;
a primary fuel supply connected to each of the primary fuel injectors and including a primary fuel supply sensor, the primary fuel supply sensor configured to provide a primary fuel supply signal indicative of a rate of supply of a primary fuel to the engine through the primary fuel supply;
a secondary fuel supply connected to each of the secondary fuel injectors and including a secondary fuel supply sensor, the secondary fuel supply sensor configured to provide a secondary fuel supply signal indicative of a rate of supply of a secondary fuel to the engine through the secondary fuel supply;
an output shaft including a speed sensor, the speed sensor configured to measure an engine speed and to provide a speed signal;
an electronic controller operably associated with each of the primary fuel injectors, each of the secondary fuel injectors and each of the spark devices, the electronic controller disposed to receive the primary and secondary fuel supply signals and the speed signal,
wherein the electronic controller is programmed and operates to:
determine a first fueling mode for the first grouping of cylinders and a second fueling mode for the second grouping of cylinders independently based on the primary and secondary fuel supply signals and the speed signal:
wherein the electronic controller is programmed and operates to:
determine a first fueling mode for the first grouping of cylinders and a second fueling mode for the second grouping of cylinders independently based on the primary and secondary fuel supply signals and the speed signal:
wherein the first fueling mode is a dual-fuel operating mode in which the primary and secondary fuel injectors both provide amounts of their respective fuels into each of the plurality of cylinders belonging to the first grouping of cylinders with ignition provided by compression; and
wherein the secondary fuel is a gaseous fuel and wherein, in the second fueling mode each of the plurality of cylinders is operated on gaseous fuel with ignition provided by the spark device.

US Pat. No. 10,113,489

AIR SHUTOFF SWING GATE VALVE

AMOT Controls Corp., Hou...

1. An air shutoff swing gate valve, comprising:a valve body having an air passage therein for conveying an air flow therethrough;
a valve swing gate, pivotable on a swing arm that is pivotally disposed adjacent to the valve body, the swing gate pivotable from an open position wherein the swing gate is positioned adjacent to the air passage to provide for free flow of air through the air passage, to a closed position wherein the swing gate is positioned within the air passage to substantially close off the air passage;
a pivotable shaft having a longitudinal axis, the shaft extending generally perpendicular to the swing arm, the swing arm disposed on the shaft such that rotation of the shaft about the longitudinal axis causes rotation of the swing arm, to move the swing gate between the open and closed positions; and
an actuation housing for controlling said shaft rotation, said actuation housing being separate from said valve body and sealed against the environment and thermally-isolated from said valve body, said actuation housing comprising:
a trigger assembly for securing the swing gate in the open position and for triggering said pivotable shaft to rotate due to biasing from a spring, which biases said shaft towards said closed position, to cause the swing gate to move from the open position to the closed position,
wherein said trigger assembly comprises:
an actuator having a displaceable actuator shaft,
a pivotable cam that is coupled to one end of the pivotable shaft such that rotation of the pivotable shaft causes rotation of the pivotable cam, and
a rocker arm having a first end pivotably coupled to the displaceable actuator shaft, a second end pivotably coupled within the actuation housing, and a curved surface located between the first and second ends and adjacent the second end,
wherein the pivotable cam is configured to contact the curved surface of the rocker arm when the pivotable cam rotates.

US Pat. No. 10,113,482

GEARBOX FOR GAS TURBINE ENGINE

1. A gearbox for a gas turbine engine, the gearbox comprising:a gear assembly including first and second gears in driving engagement through planet gears, the planet gears rotatable about a respective central axis and supported by a carrier, the assembly connected to input and output shafts and including at least one rotatable intermediate component;
a brake configured to selectively impede rotation of the intermediate component; and
a blocking member configured to selectively impede rotation of the planet gears about the central axes;
wherein the gearbox is selectively configurable between:
a speed change configuration wherein the brake is configured to impede the rotation of the intermediate component and the blocking member is configured to allow the rotation of the planet gears about the central axes to define a speed ratio different than 1 between rotational speeds of the input and output shafts; and
a direct drive configuration wherein the brake is configured to allow the rotation of the intermediate component and the blocking member is configured to impede the rotation of the planet gears about the central axes so that the input and output shafts are rotatable together at a same rotational speed.

US Pat. No. 10,113,477

WASTEGATE BALL-VALVE

BorgWarner Inc., Auburn ...

1. A turbocharger having a wastegate valve (32) and a wastegate port (28), said wastegate valve (32) comprising:a valve seat (36, 95) which surrounds said wastegate port (28) and defines a sealing surface (38);
a valve body (34) which is movable toward and away from said wastegate port (28), said valve body (34) including a free-floating valve member (35, 61) the valve member (35) in the form of a partial sphere have the sealing surface (39) on one side and a flat interior face (41) on the opposite side which is sealingly engagable with said valve seat (36, 95) when said valve body (34) is in a closed position, said valve member (35, 61) being movably retained on said valve body (34) so as to be movable in a radial direction extending radially across said valve port (28) to allow self-centering of said valve member (35, 61) within said seat (36, 95),
wherein said valve member (35, 61) is movable on said valve body (34) so as to be displaceable radially across said wastegate port (28) in response to radial contact forces between said valve member (35, 61) and said seat (36, 95)
wherein said valve member (35, 61) is formed separate from said valve body (34) and has a sealing surface (39, 62) on one side, said valve body (34) including a pocket (42, 63) which receives said valve member (35) therein, said valve body (34) including retaining structure which interferes with said sealing surface (39, 62) to movably retain said valve member (35, 61) within said pocket (42, 63).

US Pat. No. 10,113,475

SHUNT TANK ASSEMBLY

Caterpillar Inc., Deerfi...

1. A drop tube for a shunt tank, the drop tube defining a channel along a central axis therethrough, the drop tube comprising:a plug portion having a first length;
a flange provided at a first end of the plug portion;
a transition portion provided at a second end of the plug portion, the transition portion is tapered with respect to the plug portion; and
a tube portion extending from the transition portion and terminating with a chamfered end, the tube portion has a second length greater than the first length of the plug portion, the tube portion is made of elastomeric material and configured to bend without kinking,
wherein a maximum outer diameter of the tube portion at the chamfered end, which is where coolant exits and/or enters the tube portion, is less than a maximum outer diameter of the flange and a maximum outer diameter of the plug portion, and
wherein, in a side view, a sidewall of the chamfered end of the tube portion forms a point as an end-most portion of the chamfered end.

US Pat. No. 10,113,471

MULTILAYER COMPOSITE PANEL

Hyundai Motor Company, S...

1. A multi-layered composite panel, comprisingat least two sheets of thin plates, wherein the two sheet of thin plates include continuous waveform patterns having the same pitch and different heights in one direction and are overlapped, and an adiabatic layer is formed between the overlapping thin plates;
diagonal pressing portions, which divide the waveform patterns on the top and the bottom of the thin plates into the unit of triangle-patterned cell by being pressed diagonally to cross each other on the top and the bottom of the thin plates overlapping in the diagonal direction crossing the direction of the waveform patterns, are formed; and
an undercut portion is formed by pressing the centers of both sides connecting a groove and a ridge of each cell on the top and the bottom of the thin plates with opposite diagonal pressing portions.

US Pat. No. 10,113,467

CATALYST STORAGE CASE, EXHAUST DUCT, AND ENGINE

Yanmar Co., Ltd., Osaka-...

1. An engine comprising:a cylinder block having a cylinder;
a cylinder head attached to the cylinder block, the cylinder head having an exhaust port communicating with an interior of the cylinder; and
a catalyst storage case attached to the cylinder head, wherein the catalyst storage case comprises:
a case body having an inlet, an outlet, and an exhaust passage extending from the inlet to the outlet for allowing exhaust gas to pass therethrough; and
a plurality of oxidation catalysts disposed in the exhaust passage of the case body, wherein
the plurality of oxidation catalysts are arrayed in a direction intersecting a direction along which the exhaust passage extends,
the inlet of the catalyst storage case is in communication with the exhaust port of the cylinder head,
the cylinder block has a piston disposed in the cylinder and a crankshaft coupled to the piston,
the cylinder block has a load-side end face from which a load-side end of the crankshaft protrudes,
the catalyst storage case is disposed toward the load-side end face of the cylinder block, and
the plurality of oxidation catalysts in the catalyst storage case are arrayed in a direction intersecting a shaft center of the crankshaft.

US Pat. No. 10,113,455

REGULATOR ASSEMBLY

Caterpillar Inc., Deerfi...

1. A regulator assembly comprising:a main body including:
a first end;
a second end distal with respect to the first end;
a first passage extending from the first end at least partially towards the second end;
a second passage axially aligned with, connected to, and extending from the first passage towards the second end, the second passage having a diameter greater than a diameter of the first passage; and
a seat defined at an intersection of the first passage and the second passage,
wherein the main body is configured to be coupled to a fluid line at the first end and the second end;
a valve element configured to be disposed within the second passage of the main body, the valve element configured to move within the second passage, the valve element including:
a head portion configured to engage with the seat of the main body, the head portion further including a projection having a first surface and a second surface, the projection including a plurality of apertures provided through the first surface;
a tail portion distal with respect to the head portion; and
an internal channel extending between the head portion and the tail portion, the internal channel configured to provide fluid communication between the head portion and the tail portion, the internal channel provided in fluid communication with the plurality of apertures; and
a spring element provided within the second passage and in contact with the second surface of the projection of the head portion, the spring element configured to move the valve element within the second passage,
wherein direct fluid communication between the plurality of apertures of the valve element and the first passage of the main body is discontinued when the head portion is in contact with the seat, and
wherein the plurality of apertures of the valve element are in direct fluid communication with the first passage of the main body when the valve element is not in contact with the seat.

US Pat. No. 10,113,442

METHOD OF RELEASING A FAN BLADE AND ASSEMBLY FOR RELEASING A FAN BLADE FROM A TURBOFAN ENGINE

Rolls-Royce Corporation, ...

1. A method of releasing a fan blade for testing a turbofan engine, comprising:providing a blisk airfoil;
providing a hole in the blisk airfoil at least partially aligned with a contour of the blisk airfoil;
packing the hole with an explosive charge such that at least an outside portion of the explosive charge is surrounded by the blisk airfoil and disposed within the hole;
modifying the blisk airfoil such that at least a portion of the blisk airfoil is releasable along a chordwise length of the blisk airfoil; and
detonating the explosive charge such that at least substantially all of the portion of the blisk airfoil is released at a selected time.

US Pat. No. 10,113,432

ROTOR SHAFT WITH COOLING BORE INLETS

ANSALDO ENERGIA SWITZERLA...

1. A rotor shaft adapted to rotate about a rotor axis of the rotor shaft, the rotor shaft comprising: a rotor cavity configured concentrically or quasi-concentrically to the rotor axis inside the rotor shaft, a plurality of cooling bores extending outward from the inside to an outside of the rotor shaft and towards a direction of rotation of the rotor shaft, each of the plurality of cooling bores having a bore inlet and a bore outlet, wherein the each of the plurality of cooling bores comprises a constant cooling bore diameter extending from the bore inlet to the bore outlet, the respective bore inlet being adapted to abut on the rotor cavity, and wherein at least one side or part-side of the circumferential area of the bore inlet is provided with an edge fillet in order to maximize a wall thickness downstream of the edge fillet between two adjacent cooling bores, and wherein the edge fillet of each of the plurality of cooling bores has a radius of 0.3 to 0.7 of the cooling bore diameter and an opposite side of the bore inlet is without an edge fillet, and wherein the edge fillet of each of the plurality of plurality of cooling bores is arranged on a front of the bore in the direction of rotation of the rotor shaft.

US Pat. No. 10,113,394

MULTI-STAGE FLOW DEVICE

SMITH INTERNATIONAL, INC....

1. A multi-stage flow sub, comprisinga housing having a first axial bore;
a sleeve within the first axial bore of the housing, the sleeve defining a second axial bore, the sleeve further including:
a ball seat;
a first flow passage extending radially through a body of the sleeve, the first flow passage proximate to and uphole of the ball seat; and
a second flow passage extending radially through the body of the sleeve, the second flow passage being axially offset from the first flow passage;
a first burst disc in fluid communication with the first flow passage, the first burst disc obstructing radial fluid flow through the first flow passage; and
a second burst disc in fluid communication with the second flow passage, the second burst disc obstructing radial fluid flow through the second flow passage, the second burst disc further having a burst pressure higher than a burst pressure of the first burst disc.

US Pat. No. 10,113,387

TESTABLE ISOLATION PACKER

Halliburton Energy Servic...

1. A method for testing an isolation packer in a wellbore casing, comprising:(a) running at least one testable isolation packer system into the wellbore casing on a completion string, the testable isolation packer system comprising:
upper and lower packer elements;
a bypass system, comprising (i) a lower element port in fluid communication with an annulus space between the upper and lower packer elements, (ii) a release port for releasing fluid to a space downhole of the lower packer element, and (iii) a channel for directing fluid from the lower element port to the release port, wherein when the bypass system is in by-pass mode, fluid trapped between the upper and lower packer elements enters the lower element port, travels through the channel, and exits at the release port downhole of the lower packer element;
a testing subassembly comprising a flow path extending from inside of the completion string to the annulus space between the upper and lower packers elements, the flow path controlled by an external moveable element positioned circumferentially around an inner mandrel, the external movable element comprising (i) an outer port in fluid communication with the annulus space between the upper and lower packer elements and (ii) a sealing element, wherein the moveable element is movable with respect to the inner mandrel, wherein the inner mandrel comprises an inner port that is in fluid communication with the inside of the completion string, wherein movement of the external movable element moves the outer port and the sealing element uphole or downhole relative to the inner port;
wherein when the testing subassembly is in a non-test mode, the outer port is positioned on a first side of the inner port and the flow path is closed via the sealing element, and
wherein when the testing subassembly is in a test mode, movement of the external movable element causes the outer port and the sealing element to move past the inner port, opening the flow path;
(b) starting to set the upper packer element between the wellbore casing and the completion string;
(c) starting to set the lower packer element between the wellbore casing and the completion string;
(d) allowing bypass of fluid from the annulus space between the upper packer element and the lower packer element to a location downhole of the lower packer element through the bypass system; and
(e) causing the movable element to travel and (i) close the bypass system and (ii) open the testing subassembly.

US Pat. No. 10,113,383

POSITIVE RETENTION LOCK RING FOR TUBING HANGER

VETCO GRAY, LLC, Houston...

1. A wellhead assembly comprising:a wellhead housing, the wellhead housing having a bore with an axis and an annular lock groove on an inner diameter surface of the bore;
a wellbore member concentrically located within the bore of the wellhead housing defining an annulus between the wellbore member and the wellhead housing, the wellbore member having an upward facing shoulder;
an annular lock ring positioned in the annulus, the annular lock ring having an outer diameter profile for engaging the lock groove and being radially expandable from an unset position to a set position, the set position preventing upward axial movement of the wellbore member relative to the wellhead housing, the lock ring having an inward and upward facing tapered surface;
an energizing ring positioned in the annulus above the lock ring, the energizing ring being axially movable from an upper position to a lower position, the energizing ring having an outward and downward facing lower tapered surface that engages the upward facing tapered surface of the lock ring to push the lock ring outward to the set position as the energizing ring moves downward; and
a retainer in selective engagement with the energizing ring, the retainer engaging a top surface of the energizing ring when the energizing ring is in the lower position, retaining the annular lock ring in the set position and limiting axial upward movement of the energizing ring relative to the wellbore member, the retainer engaging a lower upward facing annular shoulder of the energizing ring when the energizing ring is in the upper position, limiting axial movement of the energizing ring via the lower upward facing annular shoulder, and retaining the annular lock ring and the energizing ring with the wellbore member when the annular lock ring is in the unset position.

US Pat. No. 10,113,381

DOWNHOLE AMPLIFICATION TOOL

Coil Tubing Technology, I...

1. An amplification device, comprising:a knocker bit having a hammer surface proximate its lower end;
a bottom sub having an anvil surface proximate its upper end;
an outer amplification spring;
an inner amplification spring, wherein the inner amplification spring is smaller in diameter than the outer amplification spring and wherein the inner amplification spring is disposed, at least partially, within the outer amplification spring; and
wherein the outer amplification spring and the inner amplification spring extend at least partially between the hammer surface and the anvil surface.

US Pat. No. 10,113,378

SYSTEM AND METHOD FOR MANAGING PRESSURE WHEN DRILLING

Halliburton Energy Servic...

1. A pressure management device of a drilling system comprising:a housing;
a primary bearing package coupled to the housing such that the primary bearing package is not removable from the housing and configured to rotate with respect to the housing;
a secondary bearing package uphole from the primary bearing package, the secondary bearing package configured to rotate with respect to the housing and be installed without removing the primary bearing package, the secondary bearing package including an engagement assembly extending into the primary bearing package; and
a sealing package configured to automatically seal between a drill pipe and the secondary bearing package in response to an insertion of the drill pipe through the housing.

US Pat. No. 10,113,364

METHOD AND APPARATUS FOR ISOLATING AND SWITCHING LOWER VOLTAGE PULSES FROM HIGH VOLTAGE PULSES IN ELECTROCRUSHING AND ELECTROHYDRAULIC DRILLS

SDG LLC, Minden, NV (US)...

1. A method of providing a high voltage pulse to an electrocrushing or electrohydraulic drill bit, the method comprising:providing a transformer comprising a core comprising a saturating high relative permeability magnetic material;
the transformer delivering a high voltage pulse to an electrocrushing or electrohydraulic drill bit to initiate arc formation in a substrate being drilled;
isolating lower voltage electrical components from the high voltage pulse;
saturating the transformer core, thereby lowering its relative permeability; and
the lower voltage components delivering a lower voltage high current pulse through the transformer and to the electrocrushing or electrohydraulic drill bit for powering the arc in the substrate and saturating the transformer core.

US Pat. No. 10,113,359

STEADY-STATE GEAR STRUCTURE FOR ROLLER SHADE

My Home Global Company, ...

1. A gear structure comprising:at least one return wheel unit (1); and
a power transmission unit (2) connected with the at least one return wheel unit;
wherein:
the at least one return wheel unit includes a housing (11), a first wheel (12) mounted in the housing, a second wheel (13) mounted in the housing, and a spring (14) wound around the first wheel and having a distal end (141) secured to the second wheel;
the housing has an interior defining a receiving space (110) which has a bottom provided with two fitting portions (111);
the housing has a first side provided with a first passage (113) and a second side provided with a second passage (112);
the first wheel has a center provided with a first shaft (121) rotatably mounted on one of the two fitting portions and has a periphery provided with a first annular groove (122);
the first wheel is provided with a first gear (123) protruding outward from the first passage of the housing;
the second wheel has a center provided with a second shaft (131) rotatably mounted on the other one of the two fitting portions and has a periphery provided with a second annular groove (132);
the second wheel is provided with a second gear (133) protruding outward from the second passage of the housing;
the spring is wound around the first annular groove of the first wheel;
the distal end of the spring is secured to the second annular groove of the second wheel;
the power transmission unit includes a side bracket (21) juxtaposed to the housing of the at least one return wheel unit, a first driven gear set (22) mounted in the side bracket, a second driven gear set (23) mounted in the side bracket, a driving member (25) mounted on the side bracket, and a transmission member (24) connected between the driving member and the second driven gear set;
the side bracket has an interior defining a receiving chamber (210) which has a bottom provided with a first mounting portion (213) and has a side provided with a second mounting portion (214);
the side bracket has a surface provided with an opening (211);
the side bracket is provided with an extension (212);
the first driven gear set has a center provided with a first spindle (221) rotatably mounted on the first mounting portion of the side bracket;
the first driven gear set includes a third gear (222) and a first bevel gear (223) connected with the third gear;
the third gear of the first driven gear set meshes with the second gear of the second wheel;
the second driven gear set has a center provided with a second spindle (231) rotatably mounted on the second mounting portion of the side bracket;
the second driven gear set includes an engaging portion (233) and a second bevel gear (232) connected with the engaging portion;
the second bevel gear of the second driven gear set meshes with the first bevel gear of the first driven gear set;
the driving member is rotatably mounted on the extension of the side bracket;
the driving member has a first end provided with a driving portion (251) engaging the transmission member and a second end provided with a connecting portion (252);
the transmission member is mounted on the extension of the side bracket and extends through the opening of the side bracket; and
the transmission member engages the engaging portion of the second driven gear set.

US Pat. No. 10,113,330

EXPANDABLE MAT-BASED SUN SHELTER

Imam Abdulrahman Bin Fais...

1. A collapsible sun shelter, comprising:a single transverse arch support, and
rollable flat mat,
wherein the rollable flat mat is configured to expand to include a canopy section having a spiral-like pattern,
wherein the rollable flat mat comprises a floor area portion, an upwardly deployable area portion, at least two mat anchor points and at least two arch support openings,
wherein the upwardly deployable area portion is defined by an outer perimeter passing through at least one layer of the rollable flat mat such that the upwardly deployable area portion remains connected with the floor area portion when the upwardly deployable area portion is extended upwardly in a deployed configuration,
wherein the upwardly deployable area portion of the canopy section comprises at least one point of contact and/or point of attachment with the single transverse arch support.

US Pat. No. 10,113,318

FLOOR PANEL FOR FORMING AND ENHANCED JOINT

FLOORING INDUSTRIES LIMIT...

1. A floor panel having a thickness and a centerline, the thickness defined between an uppermost and a lowermost surface of the floor panel, the centerline located at a middle of the thickness of the floor panel, the floor panel which, at least at two opposite edges is provided with profiled edge regions, which, comprise coupling parts substantially comprising a tongue and a groove, the groove being bordered in an upward direction by an upper lip and in a downward direction by a first portion of a lower lip, the lower lip having a second portion projecting distally from said first portion of the lower lip, wherein said coupling parts in coupled condition of two of such floor panels effect a locking in vertical direction, and wherein the profiled edge regions further comprise locking parts, which, in a coupled condition of two of such floor panels, effect a locking in a horizontal direction, wherein at least one of the aforementioned locking parts is provided at the tongue,wherein said groove is bordered by said lower lip, as well as by the upper lip, and that the lower lip distally extends beyond the upper lip, and
a length of the second portion of the lower lip that distally extends beyond the upper lip, measured in horizontal direction, is smaller than the thickness of the floor panel, and
wherein said coupling parts and locking parts are arranged such that they allow that two floor panels are laterally interconnected or coupled by coupling by turning the floor panels into each other along their edges, and
wherein a space is defined in front of the tongue, and extends from an innermost area of the groove at least to a tip of the tongue, the space being completely situated above the center line of the floor panel;
wherein the space continues to a contact surface between the tongue and the groove, and the space over its entire extension is located completely above the center line.

US Pat. No. 10,113,297

BACK GUARD ATTACHABLE TO A BUCKET, METHOD OF FORMING THE BACK GUARD, AND BUCKET ASSEMBLY INCLUDING THE BACK GUARD

R2 MANUFACTURING LLC, Po...

1. A back guard attachable to a bucket, the back guard comprising:a left support attachable to a left side of the bucket;
a right support attachable to a right side of the bucket;
a back support connectable to the left support and the right support, the back support extending upwardly from a rear side of the bucket, in a state where the back guard is attached to the bucket; and
an adjustment mechanism that permits the back support to accommodate different buckets having different widths,
wherein the left support includes a left side post and a first left bar that extends from the left side post laterally toward the right side of the bucket, in the state where the back guard is attached to the bucket,
wherein the right support includes a right side post and a first right bar that extends from the right side post laterally toward the left side of the bucket, in the state where the back guard is attached to the bucket,
wherein the back support includes a first bar and a support plate fixed to the first bar, the support plate and the first bar extending between the left side post and the right side post, in the state where the back guard is attached to the bucket, and
wherein the adjustment mechanism includes the first left bar and the first bar that are slideably arranged from a left side of the back support, and the first right bar and the first bar that are slideably arranged from a right side of the back support, in the state where the back guard is attached to the bucket, to allow the back support to accommodate buckets having different widths,
wherein the back support is:
laterally displaceable relative to the left and right side posts, and
anchored to at least one of the first left or right bar, in the state where the back guard is attached to the bucket to prevent the back support from laterally displacing relative to the left and right supports during use.

US Pat. No. 10,113,288

CONCRETING FACILITY AND CORRESPONDING CONCRETING METHOD

SOLETANCHE FREYSSINET, R...

1. A method of concreting an excavation, the method comprising:placing a concreting column in the excavation for concreting, wherein the concreting column extends between an open top end and a bottom end thereof;
at least partially filing the concrete column with a fluid other than concrete; and
performing a first concreting cycle, wherein the first concreting cycle comprises a priming step comprising:
inserting concrete into the concreting column via the open top end to expel the fluid other than concrete from the concreting column;
filing the concreting column with concrete; and
retaining a volume of concrete a distance from the open top end such that a height of an empty space, defined between the volume of concrete and one of the open top end and the bottom end of the concreting column, remains less than a predetermined limit value, wherein retaining the volume of concrete comprises at least partially constricting a flow section inside the concreting column and/or to the outside of the concreting column.

US Pat. No. 10,113,247

SEMICONDUCTOR SINGLE CRYSTAL PULLING APPARATUS AND METHOD FOR REMELTING SEMICONDUCTOR SINGLE CRYSTAL USING THIS

SHIN-ETSU HANDOTAI CO., L...

1. A method for remelting a semiconductor single crystal which is a method for immersing a lower end portion of the semiconductor single crystal in a melt and remelting the same by using a single crystal pulling apparatus, the single crystal pulling apparatus comprising a heater for performing heating and thermal insulation to a crucible containing a melt and a wire for growing a semiconductor single crystal while pulling the same from the melt,wherein the semiconductor single crystal pulling apparatus comprises:
a remelting detection apparatus which detects that remelting of a lower end portion of the semiconductor single crystal is completed from a change in weight of the semiconductor single crystal when the lower end portion of the semiconductor single crystal is immersed in the melt so as to be remolten by using the wire; and
a lowermost end detection apparatus which detects a lowermost end of the semiconductor single crystal from a position where no current flows between the semiconductor single crystal and the melt when the semiconductor single crystal is taken up with the use of the wire while applying a voltage between the semiconductor single crystal and the melt by applying a voltage between the crucible and the wire,
the method comprising:
a crystal immersion step of immersing the lower end portion of the semiconductor single crystal in the melt and remelting the lower end portion by lowering the wire of the single crystal pulling apparatus;
a remelting detection step of detecting that melting of the lower end portion of the semiconductor single crystal immersed in the melt is completed from a change in weight of the semiconductor single crystal by using the remelting detection apparatus;
a lowermost end detection step of taking up the semiconductor single crystal with the use of the wire while applying a voltage between the semiconductor single crystal and the melt, and detecting a lowermost end of the semiconductor single crystal from a position where no current flows between the semiconductor single crystal and the melt by using the lowermost end detection apparatus; and
a determination step of determining whether the crystal immersion step is to be restarted or whether the remelting is to be terminated after end of the lowermost end detection step.

US Pat. No. 10,113,215

MAKING MINERAL SALTS FROM VARIOUS SOURCES

LIXIVIA, INC., Santa Bar...

1. A mixture utilized in lixiviant extraction of a metal hydroxide forming species from a raw material comprising:a raw material comprising an insoluble metal salt, wherein the insoluble metal salt comprises the metal hydroxide forming species; and
a lixiviant solution comprising an organic amine cation and a counterion,
wherein the lixiviant solution is formulated to transfer the counterion to the insoluble metal salt to form an uncharged organic amine, and wherein the uncharged organic amine is formulated to react with an acid to regenerate the organic amine cation, and
wherein the organic amine cation is present in a substoichiometric amount relative to the insoluble metal salt.

US Pat. No. 10,113,211

METHOD OF MAKING A DUAL HARDNESS STEEL ARTICLE

ATI PROPERTIES LLC, Alba...

1. A method of manufacturing a dual hardness steel article, comprising:providing a first air hardenable steel alloy part comprising a first mating surface and having a first part hardness;
providing a second air hardenable steel alloy part comprising a second mating surface and having a second part hardness, wherein the first part hardness is greater than the second part hardness;
disposing the first air hardenable steel alloy part and the second air hardenable steel alloy part so that at least a portion of the first mating surface contacts at least a portion of the second mating surface;
metallurgically securing the first air hardenable steel alloy part to the second air hardenable steel alloy to form a metallurgically secured assembly;
hot rolling the metallurgically secured assembly to form a metallurgical bond between the first mating surface and the second mating surface; and
cooling the hot rolled assembly.

US Pat. No. 10,113,185

UTILIZATION OF PHOSPHOKETOLASE IN THE PRODUCTION OF MEVALONATE, ISOPRENOID PRECURSORS, AND ISOPRENE

Danisco US Inc., Palo Al...

1. Recombinant microbial cells capable of producing isoprene, wherein the cells comprise (a) one or more heterologous nucleic acids encoding a polypeptide having phosphoketolase activity; (b) attenuated activity of an acetate kinase enzyme by (i) deletion of an endogenous acetate kinase gene; or (ii) replacement of an endogenous promoter of the endogenous acetate kinase gene with a synthetic constitutively low-expressing promoter; (c) one or more nucleic acids encoding one or more polypeptides of the complete MVA pathway; and (d) a heterologous nucleic acid encoding an isoprene synthase polypeptide, wherein culturing of said recombinant cells in a suitable media provides for the production of isoprene, and wherein the production of isoprene is increased relative to cells that do not comprise the one or more heterologous nucleic acids encoding a polypeptide having phosphoketolase activity.

US Pat. No. 10,113,151

COMPOSITION OF VIRAL VECTORS IN LECITHIN LIPOSOMES, PREPARATION METHOD AND TREATMENT METHODS

The Regents of the Univer...

1. A method of preparing a formulation comprising a viral particle encapsulated in an anionic liposome, wherein the viral particle is a recombinant adenovirus, the method comprising:a) preparing a mixture by dissolving lecithin, cholesterol and PEG in an organic solvent;
b) drying the mixture under vacuum to form a dry lipid film;
c) mixing the dried lipid film with recombinant adenovirus particles and hydrating the dried lipid film by exposing it to a physiological solution, and thereby forming multilamellar vesicles;
d) sonicating said vesicles and thereby forming a formulation with recombinant adenovirus particles encapsulated in the anionic liposomes;
e) binding non-encapsulated recombinant adenovirus particles with an antibody; and
f) separating the encapsulated recombinant adenovirus particles from the non-encapsulated recombinant adenovirus particles bound to the antibody by magnetic immunoprecipitation with magnetic beads linked to protein G; and thereby extracting the non-encapsulated recombinant adenovirus particles from the formulation.

US Pat. No. 10,113,133

RANDOM COPOLYMERS OF ACRYLATES AS POLYMERIC FRICTION MODIFIERS, AND LUBRICANTS CONTAINING SAME

AFTON CHEMICAL CORPORATIO...

1. A random copolymer obtained from polymerizing an acrylate monomer composition, wherein the monomer composition comprises:a) from about 5 to about 55 mole % of at least one short chain acrylate of Formula (I),
in which Ra is hydrogen or methyl, and R1 is a linear or branched C1 to C10 alkyl radical;b) from about 0 to less than about 75 mole % of at least one long chain acrylate of Formula (II),
in which Rb is hydrogen or methyl, and R2 is a linear or branched C11 to C15 alkyl radical;c) from about 0 to less than about 75 mole % of at least one long chain acrylate of Formula (III),
in which Rc is hydrogen or methyl, and R3 is a linear or branched C16 to C30 alkyl radical; andd) from about 5 to about 50 mole % of at least one polar acrylate of Formula (IV),
in which Rd is hydrogen or methyl, A is a linear or branched C2 to C6 alkyl radical, aromatic radical, or a polyether of the formula (—CHR4CH2—O—)n where R4 is hydrogen or methyl and n is from 1 to 10; and X is COOH or OH;wherein,at least one of Ra , Rb , Rc , and Rd is methyl;
the long chain acrylate of component b) and component c) together total from about 35 mole % to about 75 mole % of the acrylate monomers;
the ratio of short chain acrylate to long chain acrylate is from about 0.05 to about 2; and
the copolymer has an Mn of 1000 to 8000 g/mol.

US Pat. No. 10,113,124

CONTROL UNIT FOR GASIFICATION POWER GENERATION PLANT, GASIFICATION POWER GENERATION PLANT, AND CONTROL METHOD FOR GASIFICATION POWER GENERATION PLANT

MITSUBISHI HITACHI POWER ...

1. A control unit for a gasification power generation plant including a gasifier that gasifies carbon-containing fuel by using an oxidizer, a gas turbine that is driven by combustion gas generated by combustion of fuel gas obtained by purifying synthesis gas from the gasifier in gas clean-up equipment, and an oxidizer supply path for supplying air extracted from an air compressor of the gas turbine or oxygen separated from the air as an oxidizer for the gasifier,the control unit for the gasification power generation plant comprising a switching unit for choosing a fixed-air-ratio mode, in which an air ratio representing the ratio of the amount of the oxidizer that is supplied to the gasifier relative to a theoretical amount of the oxidizer for combustion of the carbon-containing fuel is fixed, in a case where the gasification power generation plant is in a stable state, whereas choosing a variable-air-ratio mode, in which the air ratio is variable by varying an oxidizer amount in accordance with a load of the gasification power generation plant so that the air ratio is decreased, in a case where an operating-state quantity of the gasifier has varied or in a case where the load of the gasification power generation plant has varied.

US Pat. No. 10,113,116

LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION EMPLOYING THE SAME

DAXIN MATERIALS CORPORATI...

1. A liquid crystal composition, comprising: a first component and a third component; whereinthe first component comprises at least two liquid crystal compounds represented by Formula (I)

wherein
R1 represents hydrogen, a C1-C10 alkyl group, or a C2-C10 alkenyl group, where the C1-C10 alkyl group or the C2-C10 alkenyl group is unsubstituted or at least one —CH2— of the C1-C10 alkyl group or the C2-C10 alkenyl group is replaced by —O—, —S—, —O—CO—, —OC—O—, or —O—CO—O—, provided that the —O—, —S—, —O—CO—, —OC—O—, and —O—CO—O— do not directly bond to one another, and/or at least one hydrogen of the C1-C10 alkyl group or the C2-C10 alkenyl group is substituted by halogen, CN, or CF3;
each of A1, A2, A3, and A4 independently represents a 1,4-phenylene group, a 1,4-cyclohexylene group, a divalent dioxabicyclo[2.2.2]octylene group, a divalent trioxabicyclo[2.2.2]octylene group, or a divalent 2,5-indanylene group, where the 1,4-phenylene group, the 1,4-cyclohexylene group, or the divalent 2,5-indanylene group is unsubstituted or at least one hydrogen of the 1,4-phenylene group, the 1,4-cyclohexylene group, or the divalent 2,5-indanylene group is substituted by halogen, CN, or CF3, and/or at least one —CH2— of the 1,4-cyclohexylene group is replaced by —O—, —S—, —O—CO—, —OC—O—, or —O—CO—O—, provided that the —O—, —S—, —O—CO—, —OC—O—, and —O—CO—O— do not directly bond to one another, and/or at least one —CH2— of the divalent 2,5-indanylene group is replaced by —O— or —S—, provided that the —O— and —S— do not directly bond to one another;
each of Z1, Z2, Z3 and Z4 independently represents a single bond, a C1-C4 alkylene group, a C2-C4 alkenylene group, a C2-C4 alkynylene group, —O—CO—, or —CO—O—, where the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is unsubstituted or at least one hydrogen of the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is substituted by halogen, and/or at least one —CH2— of the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is replaced by —O— or —S—, provided that the —O— and —S— do not directly bond to each other, wherein at least one of Z1, Z2, Z3, and Z4 of one of the at least two liquid crystal compounds does not represent —OCF2— or —CF2O—;
X represents hydrogen, halogen, CN, CF3, or CCl3; and
each of m, n, o, and p independently represents 0 or 1, and m+n+o+p>0;
the third component comprises at least one liquid crystal compound represented by Formula (III)

wherein
R6 represents halogen, —CF3, —OCH?CF2, or —OCF3;
R5 represents hydrogen, a C1-C10 alkyl group, or a C2-C10 alkenyl group, where the C1-C10 alkyl group or the C2-C10 alkenyl group is unsubstituted or at least one —CH2— of the C1-C10 alkyl group or the C2-C10 alkenyl group is replaced by —O—, —S—, —CO—, —O—CO—, —CO—O—, or —O—CO—O—, and wherein the —O—, —S—, —CO—, —O—CO—, —CO—O—, and —O—CO—O— do not directly bond to one another, and/or at least one hydrogen of the C1-C10 alkyl group or the C2-C10 alkenyl group is substituted by halogen, CN, or CF3;
each of A7, A8, A9, and A10 independently represents a 1,4-phenylene group, a 1,4-cyclohexylene group, a divalent dioxabicyclo[2.2.2]octylene group, a divalent trioxabicyclo[2.2.2]octylene group, or a divalent 2,5-indanylene group, where the 1,4-phenylene group, the 1,4-cyclohexylene group, or the divalent 2,5-indanylene group is unsubstituted or at least one hydrogen of the 1,4-phenylene group, the 1,4-cyclohexylene group, or the divalent 2,5-indanylene group is substituted by halogen or CN, and/or at least one —CH2— of the 1,4-cyclohexylene group is replaced by —O—, —NH—, or —S—, provided that the —O—, —NH—, and —S— do not directly bond to one another, or at least one —CH2— of the divalent 2,5-indanylene group is replaced by —O—, —NH—, or —S—, provided that the —O—, —NH—, and —S— do not directly bond to one another;
each of Z7, Z8 and Z9 independently represents a single bond, a C1-C4 alkylene group, a C2-C4 alkenylene group, a C2-C4 alkynylene group, —CO—O—, or —O—CO—, where the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is unsubstituted or at least one hydrogen of the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is substituted by halogen, and/or at least one —CH2— of the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is replaced by —O— or —S—, and —O— does not directly bond to —O— or —S—, and —S— does not directly bond to —S—, and wherein at least one of Z7, Z8 and Z9 represents —OCF2— or —CF2O—; and
each of s, t, u, and v independently represents 0, 1, 2, or 3, and s+t+u+v?3.

US Pat. No. 10,113,114

APPARATUS AND METHOD FOR COATING PARTICULATE MATERIAL

BASF Corporation, Florha...

1. A method of applying a functional additive to a particulate landscaping material, the method comprising:feeding a particulate landscaping material into a mixing chamber from a hopper, the hopper comprising two opposing sides, a baffle, a conveyor, and a sensor, the two opposing sides, the baffle, and the conveyor defining a gate;
delivering a flow of additive mixture to a plurality of spray nozzles within the mixing chamber, the additive mixture comprising a functional additive and a carrier;
operating at least one of the plurality of spray nozzles to direct an atomized spray of additive mixture into the mixing chamber for contact with particulate landscaping material in the mixing chamber;
agitating the particulate landscaping material within the mixing chamber at least one of during and after directing the atomized spray of additive mixture into the mixing chamber;
conveying the particulate landscaping material with the additive mixture applied thereto to a mixing chamber outlet;
during the feeding, delivering, operating, agitating and conveying steps, intermittently determining a volumetric flow rate of the particulate landscape material through the mixing chamber by measuring the volumetric flow rate of the particulate landscape material through the gate with the sensor;
intermittently comparing the determined volumetric flow rate of the particulate landscape material to a predetermined target flow rate of the particulate landscape material;
adjusting, based on said comparing, the volumetric flow rate of the particulate landscape material through the mixing chamber by adjusting the volumetric flow rate of the particulate landscape material through the gate.

US Pat. No. 10,113,100

COMPOSITIONS WITH POLYAZIRIDINE CROSSLINKERS FOR TREATING SUBTERRANEAN FORMATIONS

Saudi Arabia Oil Company,...

1. A method of treating a subterranean formation comprising:i) providing to a subterranean formation a composition comprising:a maleic anhydride copolymer, or a salt thereof; andat least one hydrolyzed repeat unit selected from repeat units III and IV:

or a salt thereof, wherein each R5 is independently selected from —OH and NH2, provided that at least one of R5 is NH2, anda polyaziridine crosslinker having the formula:or a salt thereof, wherein:L1 and L2 at each occurrence are each independently selected from the group consisting of —C1-6 alkylene-, —C1-6 alkenylene-, —C1-6 alkynylene-, —(O—C1-4 alkylene)p-, —(C1-4 alkylene-O—)p—, —O—, —S—, NH—, and —C(?O)—, wherein said —C1-6 alkylene-, —C1-6 alkenylene-, —C1-6 alkynylene-, and —C1-4 alkylene- are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of -halo, —CN, —OH, —C1-3 alkyl, —C1-3 alkoxy, —C1-3 haloalkyl, —C1-3 haloalkoxy, -amino, —C1-3 alkylamino, and -di(C1-3 alkyl)amino;
each R3 is selected from the group consisting of —H, —C1-6 alkyl, —C1-6 alkenyl, —C1-6 alkynyl, -halo, —CN, —OH, —C1-3 alkoxy, —C1-3 haloalkyl, —C1-3 haloalkoxy, -amino, —C1-3 alkylamino, -di(C1-3 alkyl)amino, —(O—C1-4 alkylene)p-H, and (C1-4 alkylene-O—)p—C1-6 alkyl;
each R4 is selected from the group consisting of:

 wherein each of (a) and (b) is optionally substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of halo, CN, OH, amino, C1-3 alkylamino, di(C1-3 alkyl)amino, —C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy;
p at each occurrence is independently an integer from 0 to 40;
x and y at each occurrence are each independently an integer from 0 to 10;
m is an integer from 2 to 4; and
n is an integer from 0 to 4;
provided that the sum of m and n is 4; and
ii) crosslinking the maleic anhydride copolymer, or a salt thereof, and the polyaziridine crosslinker, or a salt thereof, to form a sealant.

US Pat. No. 10,113,088

LABEL MANUFACTURING METHOD AND LABEL

SATO HOLDINGS KABUSHIKI K...

1. A label manufacturing method comprising:applying a first adhesive to a base sheet to form an adhesive layer;
partially applying a second adhesive which is an acrylate-based bonding adhesive to the applied first adhesive layer, on the same side of the base sheet as the first adhesive layer;
irradiating the first adhesive and the partially applied acrylate-based bonding adhesive applied to the first adhesive layer with an ultraviolet ray such that only the acrylate-based bonding adhesive is cured; and
cutting the base sheet where the acrylate-based bonding adhesive has been applied to define a separated label.

US Pat. No. 10,113,084

MOLD RELEASE AGENT

Illinois Tool Works, Inc....

1. A mold release coating on a mold surface, the mold release coating being derived from a polysiloxane having the formula of formula 1:
where y?3 and x is ?0, where a reactive moiety for the purposes of the present invention include those moieties that react on the mold surface to form bonds to other polymers of Formula (I), the mold surface, or both, where reactive moieties comprise one or more of R4, R5, R6, or R7, where R4, R5, R6, or R7 are the same or different and each is independently one or more of reactive moieties of glycydoxy, C1-C8 alkoxy, C1-C8 alkoxy having a substituent, or independently one or more of unreactive moieties C1-C8 or longer alkyl, either branched or unbranched; and where R1 R2, R3, R8, R9, and R10 can be the same or different and each independently is a saturated C1-C8 or greater alkyl, either linear or branched with the proviso any hydrogen present in the R groups is non-labile; and
the mold surface being an inflatable elastomeric bladder surface, the polysiloxane bonded to the rubber bladder surface by reaction of the one or more reactive moieties.

US Pat. No. 10,113,057

METHOD FOR FORMING A POLYETHYLENE NANOCOMPOSITE

King Fahd University of P...

1. A method for forming a high-density polyethylene nanocomposite by polymerizing a mixture of ethylene and a calcium zirconate nanofiller, comprising:adding a zirconocene catalyst, the calcium zirconate nanofiller and a solvent to a reactor;
mixing the zirconocene catalyst and the calcium zirconate nanofiller in the solvent;
injecting ethylene into the reactor until absorption of ethylene is no longer observed; followed by
adding a methylaluminoxane cocatalyst into the reactor to from a catalyst mixture; then
polymerizing the ethylene by pressurizing the reactor with ethylene and maintaining a pressure of 1-1.5 bar to form a polymerization mixture; and then
quenching the polymerization mixture with methanol to form the high-density polyethylene nanocomposite;
wherein the calcium zirconate nanofiller is dispersed in a polyethylene matrix of the high-density polyethylene nanocomposite, and
the calcium zirconate nanofiller is not a support material for the zirconocene catalyst.

US Pat. No. 10,113,051

EPOXY ESTOLIDE FATTY ACID ALKYL ESTERS USEFUL AS BIORENEWABLE PLASTICIZERS

Regents of the University...

1. A composition comprising epoxy estolide fatty acid alkyl esters derived from triacylglycerol oil having an unsaturation of greater than 80 IV, wherein the estolide is derived from an epoxy group.

US Pat. No. 10,113,049

THERMOPLASTIC RESIN COMPOSITION

NIPPON NYUKAZAI CO., LTD....

1. A method for improving a gloss retention property of a thermoplastic resin composition comprising the step of combining(a) a thermoplastic resin, where said thermoplastic resin is not an aromatic polycarbonate resin or a polyvinyl chloride resin, and
(b) as ionically bonded salt represented by the following Chemical Formula (1) or (2):

in the Chemical Formula (I) above, R1 represents a substituted or unsubstituted linear, branched, or cyclic alkyl group having from 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms where the aryl group is not substituted with an alkyl group, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms,
A is a linear or branched alkylene group having from 2 to 4 carbon atoms,
n represents an integer of 1 to 50,
Q1 represents at least one kind selected from the group consisting of a dimethylammonium ion, a trimethylammonium ion, a diethylammonium ion, a triethylammonium ion, a monopropylammonium ion, a dipropylammonium ion, a tripropylammonium ion, a monobutylammonium ion, a dibutylammonium ion, a tributylammonium ion, a monopentylammonium ion, a dipentylaminoammonium ion, a tripentylammonium ion, a monohexylammonium ion, a dihexylammonium ion, a monoheptylammonium ion, a diheptylammonium ion, a monooctylammonium ion, a dioctylammonium ion, a monononylammonium ion, a monodecylammonium ion, a monoundecylammonium ion, a monododecylammonium ion, a monotridecylammonium ion, a monotetradecylammonium ion, a monopentadecylammonium ion, a monohexadecylammonium ion, a monoheptadecylammonium ion, a monooctadecylammonium ion, a monononadecylammonium ion, a monoicosylammonium ion, a monohenicosylammonium ion, a monodocosylammonium ion, a monotricocylammonium ion, a methyl(ethyl)ammonium ion, a methyl(propyl)ammonium ion, a methyl(butyl)ammonium ion, a methyl(pentyl)ammonium ion, a methyl(hexyl)ammonium ion, a methyl(heptyl)ammonium ion, a methyl(octyl)ammonium ion, a methyl(nonyl)ammonium ion, a methyl(decyl)ammonium ion, a methyl(undecyl)ammonium ion, a methyl(dodecyl)ammonium ion, a methyl(tridecyl)ammonium ion, a methyl(tetradecyl)ammonium ion, a methyl(pentadecyl)ammonium ion, a methyl(hexadecyl)ammonium ion, a methyl(heptadecyl)ammonium ion, a methyl(octadecyl)ammonium ion, a methyl(nonadecyl)ammonium ion, a methyl(icosyl)ammonium ion, a methyl(henicosyl)ammonium ion, a methyl(tricosyl)ammonium ion, an ethyl(propyl)ammonium ion, an ethyl(butyl)ammonium ion, an ethyl(pentyl)ammonium ion, an ethyl(hexyl)ammonium ion, an ethyl(heptyl)ammonium ion, an ethyl(octyl)ammonium ion, an ethyl(nonyl)ammonium ion, an ethyl(decyl)ammonium ion, an ethyl(undecyl)ammonium ion, an ethyl(dodecyl)ammonium ion, an ethyl(tridecyl)ammonium ion, an ethyl(tetradecyl)ammonium ion, an ethyl(pentadecyl)ammonium ion, an ethyl(hexadecyl)ammonium ion, an ethyl(heptadecyl)ammonium ion, an ethyl(octadecyl)ammonium ion, an ethyl(nonadecyl)ammonium ion, an ethyl(icosyl)ammonium ion, an ethyl(henicosyl)ammonium ion, an ethyl(tricosyl)ammonium ion, a dimethyl(ethyl)ammonium ion, a dimethyl(propyl)ammonium ion, a dimethyl(butyl)ammonium ion, a dimethyl(pentyl)ammonium ion, a dimethyl(hexyl)ammonium ion, a dimethyl(heptyl)ammonium ion, a dimethyl(octyl)ammonium ion, a dimethyl(nonyl)ammonium ion, a dimethyl(decyl)ammonium ion, a dimethyl(undecyl)ammonium ion, a dimethyl(dodecyl)ammonium ion, a dimethyl(tridecyl)ammonium ion, a dimethyl(tetradecyl)ammonium ion, a dimethyl(pentadecyl)ammonium ion, a dimethyl(hexadecyl)ammonium ion, a dimethyl(heptadecyl)ammonium ion, a dimethyl(octadecyl)ammonium ion, a dimethyl(nonadecyl)ammonium ion, a dimethyl(icosyl)ammonium ion, a dimethyl(henicosyl)ammonium ion, a dimethyl(tricosyl)ammonium ion, a monobenzylammonium ion, a (1-phenethyl)ammonium ion, a (2-phenethyl)ammonium ion, a dibenzylammonium ion, a bis(1-phenethyl)ammonium ion, a bis(2-phenethyl)ammonium ion, a monocyclopentylammonium ion, a dicyclopentylammonium ion, a tricyclopentylammonium ion, a monocyclohexylammonium ion, a dicyclohexyl ammonium ion, a monocycloheptylammonium ion, a dicycloheptylammonium ion, a dimethyl(cyclopentyl)ammonium ion, a dimethyl(cyclohexyl)ammonium ion, a dimethyl(cycloheptyl)ammonium ion, a (methylcyclopentyl)ammonium ion, a bis(methylcyclopentyl)ammonium ion, a (dimethylcyclopentyl)ammonium ion, a bis(dimethylcyclopentyl)ammonium ion, a (ethylcyclopenty)ammonium ion, a bis(ethylcyclopentyl)ammonium ion, a (methylethylcyclopentyl)ammonium ion, a bis(methylethylcyclopentyl)ammonium ion, a (diethylcyclopentyl)ammonium ion, a (methylcyclohexyl)ammonium ion, a bis(methylcyclohexyl)ammonium ion, a (dimethylcyclohexyl)ammonium ion, a bis(dimethylcyclohexyl)ammonium ion, an (ethylcyclohexyl)ammonium ion, a bis(ethylcyclohexyl)ammonium ion, a (methylethylcyclohexyl)ammonium ion, a (diethylcyclohexyl)ammonium ion, a (methylcycloheptyl)ammonium ion, a bis(methylcycloheptyl)ammonium ion, a (dimethylcycloheptyl)ammonium ion, an (ethylcycloheptyl)ammonium ion, a (methylethylcycloheptyl)ammonium ion, a (diethylcycloheptyl)ammonium ion, a monomethanolammonium ion, a dimethanolammonium ion, a monoethanolammonium ion, a diethanolammonium ion, a mono(n-propanol)ammonium ion, a di(n-propanol)ammonium ion, a monoisopropanolammonium ion, a diisopropanolammonium ion, a monobutanolammonium ion, a dibutanolammonium ion, a tributanolammonium ion, a monopentanolammonium ion, a dipentanolammonium ion, a tripentanolammonium ion, a monohexanolammonium ion, a dihexanolammonium ion, a monoheptanolammonium ion, a diheptanolammonium ion, a monooctanolammonium ion, a monononanolanamonium ion, a monodecanolammonium ion, a monoundecanolammonium ion, a monododecanolammonium ion, a monotridecanolammonium ion, a monotetradecanolammonium ion, a monopentadecanolammonium ion, a monohexadecanolammonium ion, a monomethylmonoethanolammonium ion, a monoethylmonoethanolammonium ion, a monoethylmonopropanolammonium ion, a monoethylmonobutanolammonium ion, a monoetylpentanolammonium ion, a monopropylmonoethanolammonium ion, a monopropylmonopropanolammonium ion, a monopropylmonobutanolammonium ion, a monopropylmonopentanolammonium ion, a monobutylmonoethanolammonium ion, a monobutylmonopropanolammonium ion, a monobutylmonobutanolammonium ion, a monobutylmonopentanolammonium ion, a dimethylmonoethanolammonium ion, a diethylmonoethanolammonium ion, a diethylmonopropanolammonium ion, a diethylmonobutanolammonium ion, a diethylmonopentanolammonium ion, a dipropylmonoethanolammonium ion, a dipropylmonopropanolammonium ion, a dipropylmonobutanolammonium ion, a dipropylmonopentanolammonium ion, a dibutylmonoethanolammonium ion, a dibutylmonopropanolammonium ion, a dibutylmonobutanolammonium ion, a dibutylmonopentanolammonium ion, a monomethyldiethanolammonium ion, a monomethyldipropanolammonium ion, a monomethyldibutanolammonium ion, a monomethyldipentanolammonium ion, a monoethyldiethanolammonium ion, a monoethyldipropanolammonium ion, a monoethyldibutanolammonium ion, a monoethyldipentanolammonium ion, a monopropyldiethanolammonium ion, a monopropyldipropanolammonium ion, a monopropyldibutanolammonium ion, a monopropyldipentanolammonium ion, a monobutyldiethanolammonium ion, a monobutyidipropanolammonium ion, a monobutyldibutanolammonium ion, a monobutyldipentanolammonium ion, a monocyclohexylmonoethanolammonium ion, a monocyclohexyldiethanolammonium ion, a monocyclohexylmonopropanolammonium ion, a monocyclohexyldipropanolammonium ion, a mono(?-aminoethyl)monoethanolammonium ion, a monotert-butylmonoethanolammonium ion, and a mono(?-aminoethyl)isopropanolammonium ion,

in the Chemical Formula (2) above, R2represents 1,2-Bis(2-ethylhexyloxycarbonyl)ethyl group, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms where the aryl group is not substituted with an alkyl group, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms with the proviso that the aryl group is not a naphthyl group or not substituted with a substituted or unsubstituted phenyl group,
A is a linear or branched alkylene group having from 2 to 4 carbon atoms,
n represents an integer of 1 to 50,
Q2 represents at least one kind selected from the group consisting of a monomethanolammonium ion, a dimethanolammonium ion, a monoethanolammonium ion, a diethanolammonium ion, a mono(n-propanol)ammonium ion, a di(n-propanol)ammonium ion, a monoisopropanolammonium ion, a diisopropanolammonium ion, a monobutanolammnonium ion, a dibutanolammonium ion, a tributanolammonium ion, a monopentanolammonium ion, a dipentanolammonium ion, a tripentanolammonium ion, a monohexanolammonium ion, a dihexanolammonium ion, a monononanolammonium ion, a diheptanolammonium ion, a monooctanolammonium ion, a monononanolammonium ion, a monodecanolammonium ion, a monoundecanolammonium ion, a monoclodecanolammonium ion, a monotridecanolammonium ion, a monotetradecanolammonium ion, a monopentadecanolammonium ion, a monohexadecanolammonium ion, a monomethylmonothanolammonium ion, a monoethylmonoethanolammonium ion, a monoethylmonopropanolamnonium ion, a monoethylmonobutanolammonium ion, a monoethylpentanolammonium ion, a monopropylmonoethanolammonium ion, a monopropylmonopropanolammonium ion, a monopropylmonobutanolammonium ion, a monopropylmonopentanolammonium ion, a monobutymonoethanolammonium ion, a monobutylmonopentanolammonium ion, a monobutylmonobutanolammonium ion, a monobutylmonopentanolammonium ion, a dimethylmonoethanolammonium ion, a diethylmonoethanolammonium ion, a diethylmonopropanolammonium ion, a diethylmonobutanolammonium ion, a diethylmonopentanolammonium ion, a dipropylmonoethanolammonium ion, a dipropylmonopropanolammonium ion, a dipropylmonobutanolammonium ion, a dipropylmonopentanolammonium ion, a dibutylmonoethanolammonium ion, a dibutylmonopentanolammonium ion, a dibutylmonobutanolammonium ion, a dibutylmonopentanolammonium ion, a monomethyldiethanolammonium ion, a monomethyldipropanolammonium ion, a monomethyldibutanolammonium ion, a monomethyldipetanolammonium ion, a monoethyldiethanolammonium ion, a monoethyldipropanolammonium ion, a monoethyldibutanolammonium ion, a monoethyldipentanolammonium ion, a monopropyldiethanolammonium ion, a monopropyldipropanolammonium ion, a monopropyldibutanolammonium ion, a monopropyldipentanolammonium ion, a monobutyldiethanolammonium ion, a monobutyldipropanolammonium ion, a monobutyldibutanolaumonium ion, a monobutyldipentanolammonium ion, a monocyclohexylmonoethanolammonium ion, a monocyclohexyldiethanolammonium ion, a monocyclohexylmonopropanolammonium ion, a monocyclohexyldipropanolammonium ion, a mono(?-aminoethyl)monoethanolammenium ion, a monotert-butylmonoethanolammonium ion, a monotert-butyldiethanolammonium ion, a mono(?-aminoethyl)isopronanolammonium ion, and a diethylmonoisopropanolammonium ion, wherein the thermoplastic resin composition is in the form of an emulsion when the (b) ionically bonded salt is represented by the Chemical Formula (1) above.

US Pat. No. 10,113,047

EXFOLIATED GRAPHITE-RESIN COMPOSITE MATERIAL AND METHOD FOR PRODUCING THE SAME

SEKISUI CHEMICAL CO., LTD...

1. An exfoliated graphite-resin composite material comprisingan exfoliated graphite and
a resin
said exfoliated graphite and said resin forming the exfoliated graphite-resin composite, and
when an amount of methylene blue adsorbed per g of the exfoliated graphite-resin composite material (?mol/g) is y, the amount of methylene blue adsorbed as measured based on a difference between an absorbance of a methanol solution of methylene blue at a concentration of 10 mg/L and an absorbance of a supernatant liquid obtained by introducing the exfoliated graphite-resin composite material into the methanol solution of methylene blue and performing centrifugation, and a BET specific surface area (m2/g) of the exfoliated graphite-resin composite material is x,
a ratio y/x being 0.15 or more, and the BET specific surface area being 25 m2/g or more, and
said exfoliated graphite-resin composite has a graphite structure in the central portion and has an exfoliated structure in the edge portion.

US Pat. No. 10,113,045

MOLDED FOAM ARTICLE, FOAMED SOLE, AND SHOE

ASICS CORPORATION, (JP)

1. A molded foam article comprising:a foam obtained by foaming a formation material, wherein the formation material of the foam comprises (i) at least one resin component selected from a thermoplastic elastomer, a thermoplastic resin, and a rubber, and (ii) at least one softener selected from a vegetable oil and a mineral oil,
wherein an Asker C hardness of the foam is 10 degrees or more,
wherein the at least one resin component and the at least one softener are selected such that a ratio E40/E0 of the foam is (i) equal to or more than 0.5 and (ii) equal to or less than 3.5, the ratio E40/E0 being a ratio of an elastic coefficient E40 at a compressive strain of 40% in relation to an elastic coefficient E0 at a compressive strain of 0% of the foam, and
wherein a difference between (i) H1 as an Asker C hardness when a load of 0.1 MPa is applied and (ii) H0 as an Asker C hardness in a no load state, is within a range of ±20 degrees.

US Pat. No. 10,113,044

METHODS OF PROCESSING LATEX, METHODS OF MAKING CARPET, AND CARPETS

SST Foam, LLC, Alpharett...

1. A method of processing a latex stream, the method comprising:forwarding the latex stream to a reservoir of a foam head;
disposing an isocyanate into the reservoir of the foam head to form a foamed latex stream comprising the isocyanate; and
forwarding the foamed latex stream comprising the isocyanate from the reservoir of the foam head to a coating line;
wherein the concentration of the isocyanate in the foamed latex stream is about 0.5 to about 2.25%, by weight of the latex stream.

US Pat. No. 10,113,033

POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT

POLYACTIVA PTY LTD, Melb...

1. A polymer-bioactive agent conjugate comprising:a polymer backbone comprising a plurality of triazole moieties; and
a plurality of releasable prostaglandin analogues covalently bonded to and pendant from the polymer backbone from the 1-position of the prostaglandin analogue via an ester linking group.

US Pat. No. 10,113,023

ANTISTATIC POLYMERS AND METHODS OF MAKING THE SAME

3M Innovative Properties ...

1. An antistatic polymer consisting of:divalent segments p) represented by the formula

wherein
R1 independently represents an alkyl group having from 1 to 18 carbon atoms,
R2 and R3 independently represent alkyl groups having from 1 to 4 carbon atoms,
R4 independently represents an alkylene group having from 2 to 8 carbon atoms, and
R5 independently represents H or methyl; and
divalent segments q) represented by the formula)

US Pat. No. 10,112,970

PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS

Taro Pharmaceutical Indus...

1. A process for preparing a compound of Formula I
in which R1 is OH and R2 is H, or R1 and R2 form together a double bond with O, R3 is H and R4 is CH3, or R3 is CH3 and R4 is H, and wherein at least one of X1-5 is independently Cl, Br or F, and all other of X1-5 are H, comprising the steps of:
(a) reacting a compound of formula II

in which R1-R4 and X1-5 are as defined in Formula I with Trimethylsilyl Iodide in a solution of an aprotic solvent, wherein the molar ratio between Trimethylsilyl Iodide and the compound of Formula II is about 2:1 to about 10:1;
(b) quenching the reaction of step (a);
(c) extracting the compound of Formula I from the solution of step (b) using an organic solvent to yield an organic layer comprising the compound of Formula I; and
(d) isolating the compound of Formula I from the organic layer of step (c).

US Pat. No. 10,112,966

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Alios BioPharma, Inc., S...

1. A compound selected from the group consisting of:or a pharmaceutically acceptable salt of the foregoing.

US Pat. No. 10,112,965

BICYCLIC BRIDGED METALLOCENE COMPOUNDS AND POLYMERS PRODUCED THEREFROM

Chevron Phillips Chemical...

1. A metallocene compound having the formula:wherein:M is Ti, Zr, or Hf;
each X independently is a monoanionic ligand;
E is a norbornane group, a norbornene group, a norbornadiene group, an indane group, an indene group, or a dicyclopentadiene group; and
Cp1 and Cp2 independently are a substituted or unsubstituted cyclopentadienyl, indenyl, or fluorenyl group.

US Pat. No. 10,112,961

HYDROBORATION AND BORYLATION WITH COBALT CATALYSTS

The Trustees of Princeton...

1. A method of providing a borylated product comprising:providing a reaction mixture comprising an aliphatic compound or an aromatic compound, a borylation reagent and a cobalt complex having Formula (IV):
wherein X1 and X2 are independently selected from Group VIIA of the Periodic Table and R1-R11 are independently selected from the group consisting of hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyl-aryl and alkyl-heteroaryl, wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyl-aryl and alkyl-heteroaryl are optionally substituted with one or more substituents selected from the group consisting of (C1-C10)-alkyl, (C1-C10)-alkenyl, alkoxy, halo, hydroxy, C(O)OR12, NR13R14, wherein R12-R14 are independently selected from the group consisting of hydrogen, (C1-C10)-alkyl and (C1-C10)-alkenyl;adding an activator to the reaction mixture to activate the cobalt complex; and
reacting the aliphatic compound or aromatic compound with the borylation reagent in the presence of the activated cobalt complex or a derivative of the activated cobalt complex.

US Pat. No. 10,112,956

HETEROCYCLIC COMPOUNDS HAVING CHOLESTEROL 24-HYDROXYLASE ACTIVITY

TAKEDA PHARMACEUTICAL COM...

8. A pharmaceutical composition comprising the compound or salt of claim 1 and a pharmacologically acceptable carrier.

US Pat. No. 10,112,955

ISOINDOLINE, AZAISOINDOLINE, DIHYDROINDENONE AND DIHYDROAZAINDENONE INHIBITORS OF MNK1 AND MNK2

eFFECTOR Therapeutics, In...

16. A pharmaceutical composition comprising (i) a therapeutically effective amount of at least one compound according to claim 1 or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof; (ii) in combination with a pharmaceutically acceptable carrier, diluent or excipient.

US Pat. No. 10,112,953

11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN

SITEONE THERAPEUTICS, INC...

1. A Compound of Formula (I):
where
R1 is H, OH, —OS(O)3?, —OS(O)2R5, —OC(O)R6, —NR7C(O)R7a, —OC(O)NR10R10a, —NR11R11a, —NH3+, —NR13S(O)2R13a, or —NR14C(O)NR14aR14b;
X1 is R3 and X2 is R9; or
X1 and X2 together with the —NC(O)— to which they are attached form a 5 or 6-membered ring where X1, X2, and the one or two additional ring atoms are independently selected from —C(O)—, —O—, —S—, —NR8—, and —C(R4)(R4a)— provided that only one is selected from —O—, —S—, and —NR8—; and where the 5 or 6-membered ring is optionally fused at two adjacent carbon atoms, or is optionally fused at one carbon atom and one nitrogen atom which are adjacent to each other, to a form a saturated or unsaturated 6-12 membered bicyclic ring; where the 1, 2, 3, 4, 5, or 6 additional bicyclic ring atoms are independently —CR12? or —C(R12)2—; or
X1 and X2 together with the —NC(O)— to which they are attached form 1,3-dioxo-hexahydro-1H-4,7-methanoisoindolyl;
each R4 and R4a is independently H; C1-6alkyl; or when the 6-12 membered ring is fused at a —C(R4)(R4a—, one or both of the R4 and R4a on the —C(R4)(R4a)— form a single or double bond with an adjacent ring atom;
R8 is hydrogen; C1-6alkyl; phenyl optionally substituted with 1, 2, or 3 groups independently selected from halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, and cyano; or when the 6-12 membered ring is fused at an —NR8—, the R8 forms a single bond with an adjacent ring atom;
each R12 is independently hydrogen, halo, C1-6alkyl, halo-C1-6alkyl, or aryl;
R3 is —C(O)C1-6alkyl, —C(O)OC1-6alkyl, or —C(O)phenyl where the phenyl is optionally substituted with one or two groups independently selected from halo, C1-6alkyl, halo-C1-6alkyl, C1-6alkoxy, and aryl;
R5 is H, C1-6alkyl, or aryl optionally substituted with 1, 2, 3, or 4 R5a;
each R5a, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, nitro, amino, C1-6alkylamino, di- C1-6alkylamino, phenyl, or cyano;
R9 is C1-6alkyl, C1-6alkoxy, or phenyl where the phenyl is optionally substituted with one or two groups independently selected from halo, C1-6alkyl, halo-C1-6alkyl, C1-6alkoxy, and aryl;
R6 is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R6a; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R6a; heteroaryl optionally substituted with 1, 2, 3, or 4 R6a; heterocyclic optionally substituted with 1, 2, 3, or 4 R6a; biphenyl optionally substituted on either ring with 1, 2, or 3 R6a; or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl;
each R6a, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R7 is hydrogen or C1-6alkyl;
R7a is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R7b; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R7b; heteroaryl optionally substituted with 1, 2, 3, or 4 R7b; heterocyclic optionally substituted with 1, 2, 3, or 4 R7b; biphenyl optionally substituted on either ring with 1, 2, or 3 R7b; or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl;
each R7b, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R10 is hydrogen or C1-6alkyl;
R10a is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R10b; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R10b; phenylcarbonyl where the phenyl is optionally substituted with 1, 2, or 3 R10b; heteroaryl optionally substituted with 1, 2, 3, or 4 R10b; heterocyclic optionally substituted with 1, 2, 3, or 4 R10b; biphenyl optionally substituted on either ring with 1, 2, 3, or 4 R10b, or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl;
each R10b, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R11 is hydrogen or C1-6alkyl;
R11a is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R11b; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R11b; heteroaryl optionally substituted with 1, 2, 3, or 4 R11b; heterocyclic optionally substituted with 1, 2, 3, or 4 R11b; biphenyl optionally substituted on either ring with 1, 2, 3, or 4 R11b; or cycloalkyl optionally substituted with 1, 2, or 3 groups independently selected from C1-6alkyl and halo-C1-6alkyl; and
each R11b, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R13 is hydrogen or C1-6alkyl;
R13a is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R13b; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R13b, heteroaryl optionally substituted with 1, 2, 3, or 4 R13b; heterocyclic optionally substituted with 1, 2, 3, or 4 R13b, biphenyl optionally substituted on either ring with 1, 2, 3, or 4 R13b; or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl;
each R13b, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, nitro, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R14 is hydrogen or C1-6alkyl;
R14a is hydrogen or C1-6alkyl;
R14b) is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R14c; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R14c; heteroaryl optionally substituted with 1, 2, 3, or 4 R14c; heterocyclic optionally substituted with 1, 2, 3, or 4 R14c; biphenyl optionally substituted on either ring with 1, 2, 3, or 4 R14c; or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl; and
each R14c, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, nitro, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano; or
a pharmaceutically acceptable salt, stereoisomer, tautomer, or mixture thereof.

US Pat. No. 10,112,952

FUSED TETRA OR PENTA-CYCLIC DIHYDRODIAZEPINOCARBAZOLONES AS PARP INHIBITORS

BEIGENE, LTD., Grand Cay...

1. A method of treating a disease responsive to inhibition of PARP comprising administering to a subject in need thereof a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit said PARP:wherein:RN is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
X is selected from the group consisting of C, N, O, and S;
m and n, which may be the same or different, are each an integer of 0, 1, 2, or 3;
t is an integer of 0, 1, 2, or 3;
R1, at each occurrence, is independently selected from halogen, CN, NO2, OR9, NR9R10, NR9COR10, NR9SO2R10, CONR9R10, COOR9, SO2R9, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
R2 is selected from hydrogen, COR9, CONR9R10, CO2R9, SO2R9, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
R3, R4, R5, R6, R7 and R8, which may be the same or different, are each independently selected from hydrogen, halogen, —NR9R10, —OR9, oxo, —COR9, —CO2R9, —CONR9R10, —NR9CONR10R11, —NR9CO2R10, —NR9SO2R10, —SO2R9, alkyl, alkenyl, cycloalkyl, aryl, heterocyclyl, alkynyl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, and heteroaryl is independently optionally substituted with at least one substituent R12,
or (R3 and R4), and/or (R4 and R5), and/or (R5 and R6), and/or (R6 and R7), and/or (R7 and R8), together with the atom(s) they are attached, form a 3- to 8-membered saturated, partially or fully unsaturated ring having 0, 1 or 2 heteroatoms independently selected from —NR13—, —O—, —S—, —SO— or —SO2—, and said ring is optionally substituted with at least one substituent R12,
provided that
when X is O, R5 and R6 are absent,
when X is N, R6 is absent,
when X is S, R5 and R6 are absent, or at least one of R5 and R6 is oxo,
when one of R3 and R4 is oxo, the other is absent,
when one of R7 and R8 is oxo, the other is absent, and
when X is C and one of R5 and R6 is oxo, the other is absent;
R9, R10, and R11, which may be the same or different, are each selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
R12 is selected from CN, halogen, haloalkyl, NO2, —NR?R?, —OR?, oxo, —COR?, —CO2R?, —CONR?R?, —NR?CONR?R??, —NR?CO2R?, —NR?SO2R?, —SO2R?, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein R?, R?, and R?? are independently selected from hydrogen, haloalkyl, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or (R? and R?), and/or (R? and R??) together with the atoms to which they are attached, form a 3- to 8-membered saturated, partially or fully unsaturated ring having 0, 1 or 2 additional heteroatoms independently selected from —NR13—, —O—, —S—, —SO— and —SO2—; and
R13 is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl,
wherein the cycloalkyl is a hydrocarbon group selected from saturated and partially unsaturated cyclic hydrocarbon groups, comprising monocyclic, bicyclic and tricyclic groups, and comprising from 3 to 12 carbon atoms;
wherein the heteroaryl is a group selected from:
5- to 7-membered aromatic, monocyclic rings comprising at least one heteroatom selected from N, O, and S, with the remaining ring atoms being carbon;
8- to 12-membered bicyclic rings comprising at least one heteroatom selected from N, O, and S, with the remaining ring atoms being carbon and wherein at least one ring is aromatic and at least one heteroatom is present in the aromatic ring; and
11- to 14-membered tricyclic rings comprising at least one heteroatom selected from N, O, and S, with the remaining ring atoms being carbon and wherein at least one ring is aromatic and at least one heteroatom is present in an aromatic ring; and
wherein the heterocyclyl is a ring selected from 4- to 12-membered monocyclic, bicyclic and tricyclic, saturated and partially unsaturated rings, comprising at least one carbon atoms in addition to at least one heteroatom selected from oxygen, sulfur, and nitrogen,
wherein the disease is selected from ovarian cancer or breast cancer.

US Pat. No. 10,112,950

SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS LSD1 INHIBITORS

Incyte Corporation, Wilm...

1. A method for inhibiting lysine specific demethylase-1 activity in a patient, comprising administering to the patient a therapeutically effective amount of a compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:Ring A is C6-10 aryl or 5-10 membered heteroaryl comprising carbon and 1, 2, 3, or 4 heteroatoms selected from N, O, and S, wherein said C6-10 aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3, or 4 substituents independently selected from RA;
Ring B is C6-10 aryl; 5-10 membered heteroaryl comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O, and S; C3-10 cycloalkyl; or 4-10 membered heterocycloalkyl comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O, and S; wherein said C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, and 4-10 membered heterocycloalkyl are each optionally substituted by 1, 2, 3, or 4 substituents independently selected from RB;
R1 is halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, Cy1, CN, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, C(?NRe1)Rb1, C(?NRe1)NRc1Rd1, NRc1C(?NRe1)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, or S(O)2NRc1Rd1; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy1, halo, CN, OH, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, C(?NRe1)Rb1, C(?NRe1)NRc1Rd1, NRc1C(?NRe1)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, and S(O)2NRc1Rd1;
R2 and R3 are each independently selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, Cy2, CN, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(?NRe2)Rb2, C(?NRe2)NRc2Rd2, NRc2C(?NRe2)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc2Rd2; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy2, halo, CN, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(?NRe2)Rb2, C(?NRe2)NRc2Rd2, NRc2C(?NRe2)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc2Rd2;
each RA is independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, C(?NRe4)Rb4, C(?NRe4)NRc4Rd4, NRc4C(?NRe4)NRc4Rd4, NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted by 1, 2, or 3, substituents independently selected from halo, C1-6 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, C(?NRe4)Rb4, C(?NRe4)NRc4Rd4, NRc4C(?NRe4)NRc4Rd4, NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4;
each RB is independently selected from Cy3, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)ORa5, NRc5C(O)NRc5Rd5, C(?NRe5)Rb5, C(?NRe5)NRc5Rd5, NRc5C(?NRe5)NRc5Rd5, NRc5S(O)Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, and S(O)2NRc5Rd5, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted by 1, 2, or 3 substituents independently selected from Cy3, halo, C1-6 haloalkyl, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)ORa5, NRc5C(O)NRc5Rd5, C(?NRe5)Rb5, C(?NRe5)NRc5Rd5, NRc5C(?NRe5)NRc5Rd5, NRc5S(O)Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, and S(O)2NRc5Rd5;
each Cy1, Cy2, Cy3, and Cy4 is independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from RCy;
each RCy is independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl-, C3-7 cycloalkyl-C1-4 alkyl-, (5-6 membered heteroaryl)-C1-4 alkyl-, and (4-7 membered heterocycloalkyl)-C1-4 alkyl-, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, C(?NRe6)NRc6Rd6, NRc6C(?NRe6)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)Rb6, NRc6S(O)2Rb6, NRc6S(O)2NRc6Rd6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl-, C3-7 cycloalkyl-C1-4 alkyl-, (5-6 membered heteroaryl)-C1-4 alkyl-, and (4-7 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted by 1, 2, or 3 substituents independently selected from C1-6 alkyl, C1-4 haloalkyl, C1-6 cyanoalkyl, halo, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, C(?NRe6)NRc6Rd6, NRc6C(?NRe6)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)Rb6, NRc6S(O)2Rb6, NRc6S(O)2NRc6Rd6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6;
each Ra1 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and Cy4; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy4, halo, CN, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3C(O)NRc3Rd3, C(?NRe3)Rb3, C(?NRe3)NRc3Rd3, NRc3C(?NRe3)NRc3Rd3, NRc3S(O)Rb3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3;
each Rb1, Rc1, and Rd1 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc1 and Rd1 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra2, Rb2, Rc2, and Rd2 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc2 and Rd2 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NR7S(O)2NRc7Rd7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra3, Rb3, Rc3, and Rd3 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc3 and Rd3 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra4, Rb4, Rc4, and Rd4 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc4 and Rd4 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra5, Rb5, Rc5, and Rd5 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc5 and Rd5 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra6, Rb6, Rc6, and Rd6 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc6 and Rd6 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra7, Rb7, Rc7, and Rd7 is independently selected from H, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, and C2-4 alkynyl, wherein said C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylamino, di(C1-4 alkyl)amino, C1-4 haloalkyl, and C1-4 haloalkoxy; and
each Re1, Re2, Re3, Re4, Re5, Re6, and Re7 is independently selected from H, C1-4 alkyl, and CN.

US Pat. No. 10,112,949

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Janssen Pharmaceutica NV,...

1. A compound of Formula (I)
or a stereoisomeric form thereof, wherein
R1 is phenyl or 2-pyridinyl, each of which is optionally substituted with one or more substituents each independently selected from the group consisting of halo, C1-4alkyl, monohalo-C1-4alkyl, polyhalo-C1-4alkyl, —C1-4alkyl-OH, —CN, —C1-4alkyl-O—C1-4alkyl, C3-7cycloalkyl, —O—C1-4alkyl, monohalo-C1-4alkyloxy, polyhalo-C1-4alkyloxy, SF5, C1-4alkylthio, monohalo-C1-4alkylthio and polyhalo-C1-4alkylthio;
R2 is phenyl or pyridinyl, each of which is optionally substituted with one or more substituents each independently selected from the group consisting of halo, C1-4alkyl, monohalo-C1-4alkyl, polyhalo-C1-4alkyl, —OH, —O—C1-4alkyl, —C1-4alkyl-O—C1-4alkyl, monohalo-C1-4alkyloxy, polyhalo-C1-4alkyloxy, —C1-4alkyl-OH and NR5aR5b;
wherein R5a and R5b are each independently selected from the group consisting of hydrogen or C1-4alkyl;
R3 is selected from the group consisting of hydrogen or C1-4alkyl;
R4 is selected from the group consisting of hydrogen, C1-4alkyl, monohalo-C1-4alkyl, polyhalo-C1-4alkyl, —C1-4alkyl-O—C1-4alkyl and —C1-4alkyl-OH;
or a N-oxide, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,948

BENZAMIDE OR BENZAMINE COMPOUNDS USEFUL AS ANTICANCER AGENTS FOR THE TREATMENT OF HUMAN CANCERS

The Board of Regents of t...

1. A compound according to Formula I-g
wherein
R1 is selected from the group consisting of

n=0, 1, or 2;
m=0 or 1;
R2 and R3 can be attached at any available position on the aromatic ring and are independently selected from the group consisting of H, D, F, Cl, CF3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 hydroxyalkyl, cycloalkyl, OR, N(R)2, NO2, N3, NH—C(O)—R, CN, C(O)R, C(O)OR, C(O)N(R)2, SR, alkylacyl, and arylacyl;
Each R is independently selected from the group consisting of H, C1-3 alkyl, propargyl, and phenyl;
R4 and R5 are independently selected from the group consisting of H, C1-6 alkyl optionally substituted with N(R)2, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 hydroxyalkyl, phenyl optionally substituted with R3, and CH2OC(O)-phenyl optionally substituted with R3;
R6 and R7 are independently selected from the group consisting of H, C1-3 alkyl, and C(O)OMe3;
such that all possible stereoisomers, including optically active isomers, are included whenever stereogenic centers are present;
or a pharmaceutically acceptable salt, prodrug, active metabolite, or solvate thereof.

US Pat. No. 10,112,946

COMPOSITION

GlaxoSmithKline LLC, Wil...

1. A pharmaceutical dosage form comprising Compound (I):or a pharmaceutically acceptable salt thereof, and means for providing a metered-dose of Compound (I), or a pharmaceutically acceptable salt thereof, which provides about 10 nanogrammes of Compound (I) per actuation of the metering means.

US Pat. No. 10,112,943

SUBSTITUTED IMIDAZOLES AS GAMMA SECRETASE MODULATORS

Janssen Pharmaceutica NV,...

8. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of a compound according to claim 1.

US Pat. No. 10,112,935

INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE

Lycera Corporation, Ann ...

1. A compound represented by Formula I:
or a pharmaceutically acceptable salt thereof, or a solvate of the foregoing; wherein:
R1 and R4 each represent independently for each occurrence hydrogen, halogen, C1-C3 alkyl, C1-C3 haloalkyl, cyclopropyl, C2-C4 alkenyl, or cyano;
R2 and R3 each represent independently for each occurrence hydrogen, C1-C3 alkyl, cyclopropyl, or cyano;
R5 is hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, or —CO2R12;
R6 and R7 each represent independently for each occurrence hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, or C3-C6 cycloalkyl; or R6 and R7 when attached to the same nitrogen atom may be taken together with the nitrogen atom to form a 3-7 membered ring optionally substituted with 1 or 2 R12;
R8 and R9 each represent independently for each occurrence hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C3 haloalkyl, C3-C6 cycloalkyl, —(C1-C6 alkylene)-O—(C1-C6 alkyl), or —(C1-C6 alkylene)-N(R6)(R7); or R8 and R9 when attached to the same nitrogen atom may be taken together with the nitrogen atom to form a 3-7 membered ring optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C3-C6 cycloalkyl, C1-C6 alkoxyl, cyano, hydroxyl, —CO2R6, —C(O)N(R6)(R7), —N(R6)C(O)R6, —N(R6)2, and —(C1-C6 alkylene)-CO2R6;
R10 represents independently for each occurrence C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C1-C6 hydroxyalkyl, —(C1-C6 alkylene)-O—(C1-C6 alkyl), —(C1-C6 alkylene)-N(R8)(R9), —(C1-C6 alkylene)-CO2R6, —(C1-C6 alkylene)-(3-7 membered heterocycloalkyl), or 3-7 membered heterocycloalkyl; wherein said cycloalkyl is optionally substituted by 1 or 2 C1-C6 alkyl;
R11 represents independently for each occurrence a 5-6 membered heteroaryl or 3-7 membered heterocycloalkyl, each of which is optionally substituted with 1 or 2 occurrences of Y1;
R12 represents independently for each occurrence C1-C6 alkyl or C3-C6 cycloalkyl;
A1 is a cyclic group selected from:
or dihydropyridinyl, each being optionally substituted by X1 and 0, 1, 2, or 3 occurrences of Y1;(iii) a heteroaryl selected from the group consisting a 8-10 membered bicyclic heteroaryl, a 5-membered heteroaryl, and a 6-membered heteroaryl containing at least two ring nitrogen atoms; wherein said heteroaryl is optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of X1, Y1, —(C1-C6 alkylene)-CO2R8, —N(R6)(R7), —O-(3-7 membered heterocyclyl), a 3-7 membered heterocycloalkyl, and C6 aryl;
(iv) a 3-7 membered heterocycloalkyl, C3-C7 cycloalkyl, or 8-10 membered bicyclic partially unsaturated heterocyclyl, each optionally substituted by oxo, C6 aryl, X1, and 0, 1, 2, or 3 occurrences of Y1; or
(v) aralkyl or heteroaralkyl, each being optionally substituted by a C6 aryl, X1, and 0, 1, 2, or 3 occurrences of Y1;
X1 represents independently for each occurrence:
—N(R6)C(O)-(3-7 membered heterocyclyl), —N(R6)C(O)-phenyl, —N(R6)C(O)-aralkyl, or —N(R6)C(O)-heteroaralkyl; each of which is optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of Y1 and —N(R8)(R9);
—CO2R8, —C(O)N(R8)(R9), —C(O)R11, —C(O)R12, —C(O)-(3-7 membered heterocyclyl), —C(O)N(R8)(R10), —N(R6)C(O)R10, —N(R10)C(O)R10, —N(R6)CO2R10, —N(R8)SO2R10, —N(R6)—(C1-C6 alkylene)-C(O)N(R8)(R9), —N(R6)—C(O)—(C1-C6 hydroxyalkylene)-N(R8)(R9), —N(R6)—C(O)-(2-6 membered heteroalkyl), —N(R6)C(O)N(R6)(R7), or —NO2;
—O—(C1-C6 alkylene)-CO2R8, —OC(O)R12, —O—(C1-C6 alkylene)-C(O)N(R8)(R9), —O—(C1-C6 alkylene)-N(R8)(R9), —O—(C1-C6 alkyl), —O-(3-7 membered heterocyclyl), —O—(C1-C6 alkylene)-aryl, or —O—(C1-C6 alkylene)-heteroaryl;
—SO2R10, —SO2N(R8)-heteroaryl, cyano, or —P(O)(OR8)2;
5-6 membered heteroaryl, 3-7 membered heterocycloalkyl, 3-7 membered oxo-heterocycloalkyl, or 8-10 membered bicyclic heterocyclyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of phenyl, and —N(R6)(R7); or
—(C2-C6 alkylene)-aryl, —(C2-C6 alkylene)-heterocyclyl, or —(C1-C6 alkylene)-COR12;
Y1 represents independently for each occurrence halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C3-C6 cycloalkyl, C1-C6 alkoxyl, C2-C6 alkenyl, cyano, hydroxyl, —CO2R8, —C(O)N(R8)(R9), —N(R6)C(O)R10, —N(R6)C(O)N(R6)(R7), —(C1-C6 alkylene)-CO2R8, —(C1-C6 alkylene)-O—(C1-C6 alkyl), —(C1-C6 alkylene)-N(R6)(R7), —(C1-C6 alkylene)-N(R6)S(O)2R12, —(C1-C6 alkylene)-S—C(O)R12, —S—R12, or 3-7 membered heterocycloalkyl; and
m is 0, 1, 2, or 3.

US Pat. No. 10,112,932

BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE

Genentech, Inc., South S...

1. A process for the preparation of compound 8, having the structure:
or a stereoisomer, geometric isomer, tautomer, or pharmaceutically acceptable salt thereof, wherein:
R1 is selected from the group consisting of —CH3, —CH2CH3, cyclopropyl, and cyclobutyl;
R2 is selected from the group consisting of —CH3, —CHF2, —CH2F, and —CF3;
comprising reacting compound 7, having the structure:

with an amino acid of formula H2NCH(R1)CO2H and a copper catalyst, followed by ammonium chloride, and HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate) to form 8.

US Pat. No. 10,112,927

INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)

Dana-Farber Cancer Instit...

1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof;wherein:Ring A is

each instance of RA1 is independently selected from the group consisting of hydrogen and alkyl;
each instance of RA2 is independently selected from the group consisting of hydrogen, halogen, alkyl, aryl, and heteroaryl;
Ring B is of the formula:

RB1 is selected from the group consisting of hydrogen and alkyl,
WB is CRB2, wherein RB2 is selected from the group consisting of hydrogen, cyano, halogen, optionally substituted alkyl, carbocyclyl, and ORB2a,
wherein RB2a is selected from the group consisting of hydrogen and alkyl;
or RB1 and RB2 are joined to form a carbocyclyl or aryl ring;
X is NRX—, wherein RX is hydrogen or C1-6 alkyl;
L2 is —NRL2aC(?O)— or —NRL2aS(?O)2—, wherein RL2a is hydrogen or C1-6 alkyl;
each instance of RC is independently selected from the group consisting of hydrogen, halogen, and alkyl;
n is 0, 1, 2, 3, or 4;
each instance of RD is independently selected from the group consisting of hydrogen, halogen, alkyl, and —N(RD1)2,
wherein each occurrence of RD1 is independently selected from the group consisting of hydrogen and alkyl;
p is 0, 1, 2, 3, or 4;
RE is

RE and L2 are para or meta to each other;
L3 is —NRL3a— or an optionally substituted C1-4 hydrocarbon chain, wherein RL3a is hydrogen;
RE1 is selected from the group consisting of hydrogen and alkyl;
RE2 is hydrogen or alkyl;
RE3 is selected from the group consisting of hydrogen, alkyl, —CH2ORE3a, and —CH2N(RE3a)2,
wherein each occurrence of RE3a is independently selected from the group consisting of hydrogen, alkyl,

 and alkynyl; and
Y is O;
wherein “substituted” within each of RB2 and L3, refers independently to halogen, cyano, —NO2, —OH, —ORaa, —N(Rbb)2, —SH, —SRaa,—C(?O)Raa, —CO2H, —CHO, —CO2Raa, —OC(?O)Raa, —OCO2Raa, —C(?O)N(Rbb)2, —OC(?O)N(Rbb)2, —NRbbC(?O)Raa, —NRbbCO2Raa, —NRbbC(?O)N(Rbb)2, —C(?NRbb)Raa,—C(?NRbb)N(Rbb)2,—NRbbC(?NRbb)N(Rbb)2;
each of Raa is independently alkyl; and
each of Rbb is independently hydrogen or alkyl.

US Pat. No. 10,112,924

PIPERDINYL NOCICEPTIN RECEPTOR COMPOUNDS

Astraea Therapeutics, Inc...

1. A compound of structural formula (I):
or salts, hydrates or solvates thereof wherein:

B is hydrogen;
R1 and R2 together with the carbon atoms to which they are attached form aryl, substituted aryl, heteroaryl or substituted heteroaryl;
X is hydrogen, —CH?NOR4, —C(O)NR5R6, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
Y is hydrogen, —CH?NOR7, —C(O)NR8R9, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;
R4 is hydrogen, alkyl or substituted alkyl;
R5 is hydrogen, alkyl or substituted alkyl;
R6 is hydrogen, alkyl, substituted alkyl or —OR15;
R7 is hydrogen, alkyl or substituted alkyl;
R8 and R9 are independently hydrogen, alkyl or substituted alkyl;
L is C4 cycloalkyl, C6 cycloalkyl, C7 cycloalkyl, C8 cycloalkyl, (C3-C8) substituted cycloalkyl, cyclohexyl substituted with

 (C3-C8 cycloheteroalkyl, C3 substituted cycloheteroalkyl, C5 substituted cycloheteroalkyl, C6 substituted cycloheteroalkyl, C7 substituted cycloheteroalkyl, C8 substituted cycloheteroalkyl,

US Pat. No. 10,112,921

METHOD FOR PREPARATION OF THIOPHENE-2-CARBONYL CHLORIDES WITH OXALYL CHLORIDE

LONZA LTD, Visp (CH)

1. A method for the preparation of compound of formula (III);
wherein the method comprises a step ST1;
ST1 comprises a reaction REAC1 of compound of formula (II) with oxalyl chloride;
REAC1 is done at a temperature TEMP1 of 160 to 250° C. for a time TIME1 of from 10 seconds to 24 hours; and
wherein the molar amount of oxalyl chloride is from 1.5 to 25 times based on the molar amount of compound of formula (II);

wherein R1 is H or Cl.

US Pat. No. 10,112,918

15-OXOSPIRAMILACTONE DERIVATIVES, PREPARATION METHOD AND USES THEREOF

Kunming Institute of Bota...

1. A compound of Formula II, or a solvate or a pharmaceutically acceptable salt thereof,wherein,X1 is —CH2 or —CO;
R1 and R5 independently are —OH, or carbonyl oxygen;
R2 is selected from —H, carbonyl oxygen, ?CH2, —CH2OH, —CH2OCOCH3, —CH2OSO2CH3, halogen, —CH2NR7R8 and —CH2R1;
R7 and R8 may be the same or different, or may form a N-containing 5-membered or 6-membered ring together with the N which they are linked to;
R6 is ?CH2 linked to the C atom on the ring via the double bond represented by ;
R3 and R4 are independently selected from —OH, —COCH3, —COCH2CH3, —COCH2Cl, -Ms, —CH2CN, 2-thenoyl, and benzoyl; or
R3 and R4 are independently selected from hydroxyl, carbonyloxy, C1-6alkylacyl, benzoyl, C1-6 alkylsulfonyl, phenylsulfonyl, phenylmethylsulfonyl, and cinnamoyl; wherein
R3 and R4 may be optionally substituted with one or more substituents selected from halogen, C1-6 alkyl, C1-6 alkenyl, nitro, C1-6alkoxy, triazo, trifluoromethyl, furyl, and thienyl; or
R3 and R4 are independently selected from —CO(CH2)nCH3 and —CO(CH2)nCH2X; wherein n=1-8, and X is a halogen.

US Pat. No. 10,112,898

PROCESS FOR THE PREPARATION OF SAROGLITAZAR PHARMACEUTICAL SALTS

Cadila Healthcare Limited...

1. A process for the preparation of a saroglitazar pharmaceutically acceptable salt of Formula (IB),
wherein M is a pharmaceutically acceptable cation,
the process comprising:
(a) reacting a hydroxy compound (A) with a mesylate compound (A1), in a mixture of cyclohexane and tetrahydrofuran in the presence of a base, to obtain alkoxy ester compound of Formula (II);

(b) hydrolyzing the alkoxy ester compound of Formula (II) using a base to obtain a compound of Formula (IB-1);

wherein M is a pharmaceutically acceptable cation selected from sodium, potassium, lithium, calcium, barium, strontium, and zinc;
(c) neutralizing the compound of Formula (IB-1) with an acid to obtain a compound of Formula (IB-2):

wherein M? is hydrogen; and
(d) converting the compound of Formula (IB-2) to a compound of Formula (IB).

US Pat. No. 10,112,886

METHOD FOR PURIFICATION OF BENZOIC ACID

Sulzer Chemtech AG, Wint...

1. A method for purifying a crude benzoic acid stream containing 5 to 20% by weight of byproducts and 80 to 95% by weight of benzoic acid, by means of distillation, the method comprising delivering the crude benzoic acid stream to a plant comprising a first distillation system, wherein the first distillation system comprises a divided wall column, thereby providing a purified benzoic acid stream.

US Pat. No. 10,112,881

SKIN LIGHTENING COMPOUNDS

WISYS TECHNOLOGY FOUNDATI...

1. A method of inhibiting melanin synthesis and/or removing existing pigmentation from skin, said method comprising the step of administering an effective amount of a compound having the following formula:

US Pat. No. 10,112,880

PROCESSES FOR PRODUCING CHLORINATED HYDROCARBONS AND METHODS FOR RECOVERING POLYVALENT ANTIMONY CATALYSTS THEREFROM

EAGLE US 2 LLC, Houston,...

1. A method of preparing a chlorinated alkene product by chloroalkane dehydrochlorination process, the method comprising:(a) reacting at least one chlorinated alkane in the presence of at least one polyvalent antimony catalyst in a reaction vessel, thereby forming a crude product comprising at least one chlorinated alkene product, a portion of the at least one chlorinated alkane and the at least one polyvalent antimony catalyst, the at least one chlorinated alkene product having one less chloro group (or chlorine atom) covalently bonded thereto and one less hydrogen atom covalently bonded thereto than the at least one chlorinated alkane, the at least one chlorinated alkane and the at least one chlorinated alkene product having a carbon backbone structure that is in each case the same, the at least one chlorinated alkene product having a boiling point at least about 5° C. less than the at least one chlorinated alkane; and
(b) optionally converting the polyvalent antimony catalyst to trivalent antimony catalyst to form a product comprising at least one chlorinated alkene product, at least one chlorinated alkane, and at least one trivalent antimony catalyst;
(c) separating at least a portion of the at least one chlorinated alkene product from:
(i) the product of step (a) comprising at least one chlorinated alkene product, at least one chlorinated alkane, and at least one polyvalent antimony catalyst; or
(ii) the product of step (b) comprising the at least one chlorinated alkene product, at least one chlorinated alkane, and at least one trivalent antimony catalyst by distillation; and
(d) optionally, the trivalent antimony contained in the chlorinated alkane can be converted to pentavalent antimony by the addition of chlorinating agent such chlorine gas prior to its use as a catalyst in the chlorination of hydrocarbons and/or the cracking of halohydrocarbons.

US Pat. No. 10,112,876

PROCESS FOR OLIGOMERIZATION OF ETHYLENE

SAUDI BASIC INDUSTRIES CO...

1. A process for oligomerizing ethylene, comprising:a) oligomerizing ethylene in a reactor in the presence of a solvent and a catalyst;
b) transferring a reactor overhead effluent from the reactor to an externally located cooling device to condense a portion of the reactor overhead effluent and recycling the condensed portion of the reactor overhead effluent into the reactor;
c) recovering a reactor bottom effluent from the reactor, wherein the reactor bottom effluent comprises C4 hydrocarbons, C6 hydrocarbons, C8 hydrocarbons, C10 hydrocarbons, residual C12+ hydrocarbons, residual spent catalyst, and residual polymer material;
d) transferring the reactor bottom effluent to a quenching unit, wherein quench media is added to the reactor bottom effluent, to produce a quenched reactor bottom effluent;
e) transferring the quenched reactor bottom effluent to a series of fractionation columns and, in the following order,
i) optionally separating a fraction comprising the C4 hydrocarbons from the quenched reactor bottom effluent;
ii) separating a fraction comprising the C6 hydrocarbons from the quenched reactor bottom effluent;
iii) separating a fraction comprising both the C8 hydrocarbons and C10 hydrocarbons from the quenched reactor bottom effluent and recycling said fraction comprising both the C8 hydrocarbons and C10 hydrocarbons into the reactor, and
iv) separating the residual C12+ hydrocarbons, the residual spent catalyst, the residual polymer material, and residual quench media from the quenched reactor bottom effluent,
wherein the solvent is separated from the quenched reactor bottom effluent in any of steps i)-iv) and/or in an additional step.

US Pat. No. 10,112,866

COATED ARTICLE WITH LOW-E COATING HAVING ABSORBING LAYERS FOR LOW FILM SIDE REFLECTANCE AND LOW VISIBLE TRANSMISSION

Guardian Glass, LLC, Aub...

9. A coated article including a coating supported by a glass substrate, the coating comprising:first and second infrared (IR) reflecting layers comprising silver, wherein said IR reflecting layers are spaced apart from one another by at least one dielectric layer that is located therebetween, and wherein the first IR reflecting layer is located closer to the glass substrate than is the second IR reflecting layer;
a first absorption layer comprising NiCr located such that the first absorption layer is located between the glass substrate and the first IR reflecting layer,
a second absorption layer comprising NiCr located such that both the first and second IR reflecting layers are located between the glass substrate and the second absorption layer,
wherein the first absorption layer and the second absorption layer are each sandwiched between and contacting dielectric layers;
wherein each of the first and second absorption layers comprises from 0-10% oxygen (atomic %) and from 1-15% nitrogen (atomic %);
wherein no metallic absorption layer is located between the first and second IR reflecting layers comprising silver;
wherein said coated article has a visible transmission of from about 20-43%, measured monolithically; and
wherein, measured monolithically, the coated article has a visible film side reflectance (RfY) that is lower than its visible glass side reflectance (RgY).

US Pat. No. 10,112,860

THERMOCHEMICAL REGENERATION WITH FUEL ADDITIONS

PRAXAIR TECHNOLOGY, INC.,...

1. A method of carrying out combustion in a furnace, comprising(A) combusting fuel in a furnace to produce gaseous combustion products which contain oxygen; and
(B) alternately
(1) (i) passing a portion of the gaseous combustion products out of the furnace into a first chamber, feeding hydrocarbon fuel into the first chamber, and reacting the hydrocarbon fuel in the first chamber with oxygen present in the gaseous combustion products to reduce the concentration of oxygen in the first chamber and to produce a gaseous reaction mixture containing oxygen and from zero up to 20,000 ppm of carbon monoxide;
(ii) passing the gaseous reaction mixture out of the first chamber into and through a cooled first regenerator to heat the first regenerator and cool said gaseous reaction mixture;
(iii) passing at least part of said cooled gaseous reaction mixture from said first regenerator, and fuel, into a heated second regenerator and, in the second regenerator, reacting the gaseous reaction mixture and the fuel in an endothermic reaction in the second regenerator to form syngas comprising hydrogen and CO; and
(iv) passing said syngas formed in the second regenerator into said furnace and combusting the syngas with one or more oxidant streams injected into said furnace; and
(2) (i) passing a portion of the gaseous combustion products out of the furnace into a second chamber, feeding hydrocarbon fuel into the second chamber, and reacting the hydrocarbon fuel in the second chamber with oxygen present in the gaseous combustion products to reduce the concentration of oxygen in the second chamber and to produce a gaseous reaction mixture containing oxygen and from zero up to 20,000 ppm of carbon monoxide;
(ii) passing the gaseous reaction mixture out of the second chamber into and through a cooled second regenerator to heat the second regenerator and cool said gaseous reaction mixture;
(iii) passing at least part of said cooled gaseous reaction mixture from said second regenerator, and fuel, into a heated first regenerator and, in the first regenerator, reacting the gaseous reaction mixture and the fuel in an endothermic reaction in the first regenerator to form syngas comprising hydrogen and CO; and
(iv) passing said syngas formed in the first regenerator into said furnace and combusting the syngas with one or more oxidant streams injected into said furnace.

US Pat. No. 10,112,857

METHOD AND EQUIPMENT FOR THE BIOLOGICAL DENITRIFICATION OF WASTE WATER

DEGREMONT, Paris la Defe...

1. A method for the biological denitrification of wastewater that comprises a nitrification step followed by a denitrification step, for a first fraction of the water, by a post-denitrification step during which an electron donor is injected into this first fraction, whereas a second fraction of the water passes through a bypass, and then is mixed with the first fraction downstream of the post-denitrification step, wherein:the first fraction of the wastewater is submitted, during post-denitrification, to almost complete denitrification in order to exit the step with a concentration of nitrates [N—NO3] below 4 mg/L, to minimize the production of nitrous oxide N2O,
and the bypass rate is determined from:
measurement of the concentration of nitrates [N—NO3] in the water upstream of post-denitrification,
the desired concentration of nitrates [N—NO3] for the mixture of the two fractions downstream of the post-denitrification treatment,
and the concentration of nitrates [N—NO3] in the first fraction at outlet from post-denitrification, before mixing the two fractions.

US Pat. No. 10,112,854

OLEOPHILIC BIO-BARRIER FOR CONTROLLING NAPL MIGRATION

Colorado State University...

1. A method for controlling hydrocarbons discharged from ground water to surface water at a ground water/surface water interface, comprising:placing an oleophilic biobarrier (OBB) in contact with the ground in the region of said ground water/surface water interface;
leaving the OBB in contact with the ground at the ground water/surface water interface such that naturally occurring microbes colonize within the OBB;
absorbing hydrocarbons discharged from the ground water to the surface water at the ground water/surface water interface at the OBB;
wherein said OBB comprises a first mat having a first mat upper surface and a first mat lower surface, with the first mat lower surface in contact with the ground; an oleophilic open structural layer having a structural layer upper surface and a structural layer lower surface, with the structural layer lower surface in contact with the first mat upper surface; a second mat having a second mat upper surface and a second mat lower surface, with the second mat lower surface in contact with the structural layer upper surface, thereby forming a sandwich structure having open ends; and a sand layer located above the second mat upper surface for, at least in part, enhancing the adsorption of said hydrocarbons; whereby the first and second mat are each comprised of an oleophilic material that is nutrient, water and air transmissive and effective for supporting growth of said naturally occurring microbes; and whereby the OBB is configured such that nutrients, water and air are able to transfer through the OBB; and
attenuating said hydrocarbons via biodegradation by the colonized naturally occurring microbes, thereby preventing release thereof from said ground water to said surface water;
wherein said biodegradation by the colonized naturally occurring microbes is facilitated by cycling from surface water and/or atmospheric oxygen through the OBB due to the placement of the OBB in contact with the ground in the region of said ground water/surface water interface.

US Pat. No. 10,112,847

METHOD AND APPARATUS FOR TREATING LIQUID CONTAINING IMPURITIES

PARKSON CORPORATION, For...

1. An apparatus for treating a liquid containing impurities, comprising:a filtering chamber for receiving liquid containing impurities, the filtering chamber including a lower portion containing granular media and configured to permit the granular media to interact with the liquid containing impurities, thereby removing impurities from the liquid to produce filtrate;
a filtrate section in fluid communication with the filtering chamber for receiving the filtrate, the filtrate section being in fluid communication with a first outlet for outflow of the filtrate;
a gas supplying system for delivering gas to the granular media in the filtering chamber for transport of a portion of the granular media to a granular media washer;
a reject section in fluid communication with the granular media washer for receiving a reject mixture comprising liquid and impurities from the granular media washer, the reject section being in fluid communication with a second outlet for outflow of a portion of the reject mixture; and
a control unit that is configured to determine a condition of transport of the portion of the granular media by determining whether a level of reject mixture in the reject section exceeds a predetermined threshold,
wherein, upon determining that the level of reject mixture in the reject section exceeds the predetermined threshold, the control unit is configured to send a command signal to the gas supplying system to control delivery of gas to the portion of the granular media.

US Pat. No. 10,112,844

CALCIUM CARBONATE MICROPARTICLES AND PROCESSES FOR PREPARING THEM

NIPPON PAPER INDUSTRIES C...

1. A process for preparing calcium carbonate particles having an average primary particle size of less than 1 ?m, comprising synthesizing calcium carbonate while injecting under pressure a liquid into a reaction solution in a reaction vessel, wherein the pressure in the vessel is from 0.05 MPa to 0.9 MPa.

US Pat. No. 10,112,832

OZONE GENERATOR

MITSUBISHI ELECTRIC CORPO...

7. An ozone generator comprising;a first dielectric discharge tube, consisting of a glass tube, having a closed end and an open end, and including an electrode formed on an inner surface thereof,
a first sealing lid, consisting of stainless steel or ceramics, including a main body part and a cylinder part which are connected each other, covering the open end of the first dielectric discharge tube and fixed to the first dielectric discharge tube with an adhesive,
a second dielectric discharge tube, consisting of a glass tube, having a closed end and an open end, and including an electrode formed on an inner surface thereof,
a second sealing lid, consisting of stainless steel or ceramics, including a main body part and a cylinder part which are connected each other, covering the open end of the second dielectric discharge tube and fixed to the second dielectric discharge tube with an adhesive, and
a grounding electrode, arranged concentrically with the first dielectric discharge tube and the second dielectric discharge tube;
wherein
the first dielectric discharge tube and the second dielectric discharge tube are arranged to include the closed ends facing each other,
an inside diameter of the cylinder part of the first sealing lid is larger than an outside diameter of the first dielectric discharge tube, and
an inside diameter of the cylinder part of the second sealing lid is larger than an outside diameter of the second dielectric discharge tube.

US Pat. No. 10,112,831

CHLORINE DIOXIDE GENERATOR

TAIKO PHARMACEUTICAL CO.,...

1. A method of producing chlorine dioxide comprising:generating chlorine dioxide gas by deforming a container body of a chlorine dioxide generator which is deformable in response to application of a force to the container body from outside of the container body;
the container body including a gas discharge port formed of a gas-permeable, water-impermeable or gas-permeable, water-permeation retardant member, the container body except for the gas discharge port being sealed, thus having a water-impermeable construction;
the container body containing a solid acidic composition and an aqueous chlorite solution under a non-contact condition from each other;
the solid acidic composition comprising a porous material containing an acidic substance that exhibits acidity when dissolved in water; and
the aqueous chlorite solution being sealed within a breakable enclosure;
the deforming of the container body causing the enclosure contained in the container body to be broken to bring the aqueous chlorite solution into contact with the solid acidic composition to generate chlorine dioxide gas that is discharged via the gas discharge port to outside of the container body; and
submerging in water at least the gas discharge port of the container body during the generation of the chlorine dioxide gas to dissolve the chlorine dioxide gas discharged via the gas discharge port in the water,
wherein the chlorine dioxide generator further comprises an insulating member that insulates the porous material and the enclosure from each other, the insulating member including at least one hole and being disposed to prevent displacement of the porous material toward the enclosure.

US Pat. No. 10,112,823

SEMICONDUCTOR STRUCTURES AND FABRICATION METHOD THEREOF

SEMICONDUCTOR MANUFACTURI...

1. A method for fabricating a MEMS device, comprising:providing a first wafer having a trench on a top surface of the first wafer and a fixed electrode on the bottom of the trench;
providing a second wafer with a polishing stop layer, a sacrificial layer, and a movable electrode on a top surface of the second wafer;
bonding the first wafer and the second wafer with the top surface of the first wafer facing the top surface of the second wafer and the movable electrode on the second wafer located above the trench on the first wafer;
removing the second wafer by polishing the second wafer from a backside of the second wafer until reaching the polishing stop layer; and
releasing the movable electrode by removing a portion of the polishing stop layer and the sacrificial layer to form the MEMS device.

US Pat. No. 10,112,811

SYSTEM ARRANGEMENT OF LIFTING MECHANISMS AND METHOD OF OPERATING THE SYSTEM ARRANGEMENT

M.A.T. Malmedie Antriebst...

1. A system arrangement for lifting mechanisms comprising:at least one drive motor (1, 1?);
at least one cable drum (2, 2?) connected thereto;
a reduction transmission (3) arranged between the drive motor (1, 1?) and the cable drum (2, 2?);
an automatic overrun shutdown freewheel (6);
at least one safety brake (4, 4?), and
at least one active motor locking assembly (5, 5?) to hold the load when the drive motor (1, 1?) is slowed down; a stator ring gear (20) fixedly connected to a housing of the drive motor (1, 1?), the stator ring gear (20) having a face tooth arrangement (21) operative in an axial direction; and a rotor ring gear (22) non-rotatably arranged on a motor shaft (15) of the drive motor (1, 1?), the rotor ring gear (22) being axially displaceable thereon and having an equivalent face tooth arrangement (23); wherein the rotor ring gear (22) is coupleable to the stator ring gear (20) to lock the drive motor (1, 1?).

US Pat. No. 10,112,808

WINCH

WARN INDUSTRIES, INC., C...

1. A winch, comprising:a motor having a motor housing including a motor case and a first drum support coupled to the motor case for closing an end of the motor case;
a rotatable drum;
a gear reduction unit drivingly attached to the motor, the gear reduction unit including multiple planetary gear sets and having a gear housing including a gear case and a second drum support attached to the gear case for closing an end of the gear case; and
three motor terminals linearly aligned with one another along a top side of the motor housing, vertically above the motor and protruding through a top side of the first drum support, and, where the three motor terminals electrically couple the motor to a control unit of the winch.

US Pat. No. 10,112,780

FLEXIBLE AND ADJUSTABLE ROLLER SCRAPERS

Laitram, L.L.C., Harahan...

1. A processor for processing solid objects, comprising:a frame;
a plurality of rollers extending in a longitudinal direction mounted to the frame;
a plurality of receptacles hanging at a first end of the plurality of rollers above the rollers, each receptacle including a slot with an open top;
a plurality of scrapers mounted to the frame, each scraper comprising a longitudinally extending base receiving a flexible blade that hangs down and contacts an associated roller, the base having a first mounting tab at a first end of the base, the first mounting tab including a connector extending in the longitudinal direction that is received in a slot of a corresponding receptacle, so that the position of each scraper is adjustable relative to the frame.

US Pat. No. 10,112,768

HOLLOW DISPENSING HEAD

1. A container containing a cosmetic product and provided with a dispensing head for dispensing the cosmetic product, the dispensing head comprising:a body having a crown of annular shape extending along a dispensing axis, the body being open at its two opposite axial ends in the dispensing head; and
an engaging part extending along the dispensing axis and being open at its two opposite axial ends in the dispensing head, the engaging part at least partially defining a dispensing orifice for dispensing the cosmetic product, the engaging part being inserted into the crown.

US Pat. No. 10,112,754

BOTTLE INCLUDING A SAFETY CORKING

Pernod Ricard, Paris (FR...

1. A bottle containing a beverage, such as an alcoholic beverage, said bottle comprising:a body having a neck on an upper end, the neck of the bottle ending with a mouth for receiving a plug; and
a safety corking comprising:
a security label having a first part adhered to the plug and a second part adhered on the neck of the bottle; and
a cover covering at least partially the plug and at least one part of the neck of the bottle, said cover further covering at least one part of the security label;
wherein the security label further includes:
a lower portion projecting from a lower edge of the cover and bearing a first readable code representing a unique identifier of the bottle; and
an upper portion covered by the cover, the upper portion being adhered to the plug and bearing a second readable code representing a unique identifier of the plug.

US Pat. No. 10,112,752

TUMBLER LID WITH RESERVOIR AND REPETITIVE MEASURING AND DISBURSEMENT MECHANISM

Toddy Tech, LLC, Bozeman...

1. A lid for a beverage container comprising:a refillable reservoir section,
a measuring channel having a proximal aperture and a distal aperture,
a reciprocating sealing mechanism for selectively blocking the proximal aperture and distal aperture,
an actuating mechanism mechanically joined with the reciprocating sealing mechanism controls movement of the reciprocating sealing mechanism,
a drinking access,
wherein the refillable reservoir section and the reciprocating sealing mechanism cooperate to receive and enclose an additive within the lid,
the drinking access having a wall partitioning the drinking access from the additive within the lid,
the lid permitting disbursement into the beverage container of the additive from the distal aperture in measured and repeatable quantities.

US Pat. No. 10,112,745

SELECTIVELY ACCESSIBLE CONTAINER APPARATUS, HINGE ASSEMBLY WITH A SHAPE MEMORY ALLOY FILAMENT, AND METHODS

Autosplice, Inc., San Di...

1. A selectively accessible container apparatus, comprising:a container comprising a container lid; and
a hinge assembly coupled to the container and the container lid, the hinge assembly comprising:
first and second outer housing elements configured to house a plurality of internal components therein, the plurality of internal components comprising:
a shape memory alloy (SMA) filament;
a pull rod, the pull rod configured to be communicatively coupled with the SMA filament;
an inner ratchet element and a complementary outer ratchet head, where upon activation of the SMA filament, the pull rod is configured to pull the inner ratchet element away from the complementary outer ratchet head, thereby enabling the container lid to be actuated with respect to the container; and
a return spring configured to return the inner ratchet element so as to communicatively engage the complementary outer ratchet head upon deactivation of the SMA filament.

US Pat. No. 10,112,725

ELECTRICALLY HEATED FILTER SCREENS

UNITED TECHNOLOGIES CORPO...

1. An electrically heated filter screen for a fuel system, comprising:a first heating body including:
a first heater element with a surface;
a first metallic layer with an inner surface; and
a first insulating layer sandwiched between said first heater element surface and the inner surface of said first metallic layer;
a second heating body including:
a second heater element with a surface;
a second metallic layer with an inner surface; and
a second insulating layer sandwiched between said second heater element surface and the inner surface of said second metallic layer;
a filter screen formed by the coupling of said first and second heating bodies, said filter screen having at least one aperture;
wherein said filter screen is transversely disposed within a fuel line section having an upstream and a downstream relative to said filter screen, each of said insulating layers having an exterior surface that is exposed to flowing fuel and each of said metallic layers extending from said insulating layers in an upstream direction to protect said filter screen from damage caused by objects in the flowing fuel.

US Pat. No. 10,112,723

METHOD AND A DEVICE FOR STOPPING A TURBOSHAFT ENGINE IN NOMINAL OPERATION

Airbus Helicopters, Mari...

1. A method of stopping a turboshaft engine in flight on a multi-engined aircraft, the turboshaft engine developing a current power at each instant, the turboshaft engine including a gas generator having at least one member presenting, at each instant, rotation at a current speed of rotation, the method comprising a step of generating an order to generate a stop order ordering stopping of the turboshaft engine, the method performing automatically and in succession for the turboshaft engine the following steps when the stop order is generated:a power reduction step comprising the stages of:
reducing the current power at a predetermined power variation rate to reach zero power;
reducing the current speed of rotation so that the current speed of rotation reaches a non-zero, predetermined intermediate speed when the current power becomes zero;
a temperature stabilization step during which the current speed of rotation remains equal to the intermediate speed; and
a shutdown step during which the current speed of rotation is reduced from the intermediate speed to reach zero speed.

US Pat. No. 10,112,711

AIRCRAFT DEPLOYMENT AND RETRIEVAL OF UNMANNED AERIAL VEHICLES

The Boeing Company, Chic...

1. An Unmanned Aerial Vehicle (UAV) deployment and retrieval system comprising:an aircraft having
a grappling device, and
a carousel adapted to receive and store a plurality of UAVs and positionable for deployment of a selected UAV,
each UAV in said plurality of UAVs having
a hooking device adapted for engagement by the grappling device;
a mission controller receiving a mission requirement and selecting a respective one of said plurality of UAVs;
a carousel controller responsive to the mission controller for aligning the respective one UAV for deployment; and,
a grappling device controller responsive to the mission controller for retrieving a UAV with the grappling device.

US Pat. No. 10,112,708

WEIGHT EFFICIENT SERVO ATTACHMENT SCHEME FOR RIGID COAXIAL ROTOR CONTROL SYSTEM

SIKORSKY AIRCRAFT CORPORA...

1. A rotary wing aircraft comprising:an airframe;
a main rotor system configured to rotate about a first axis of rotation;
a first stationary swashplate operably coupled to at least one first blade of the main rotor system; and
a mounting assembly for connecting the main rotor system to the airframe and holding a first servo which moves the first stationary swashplate, the mounting assembly comprising:
a leg having a first end attachable to the main rotor system and a second end attachable to the airframe, the leg being generally bent such that the first end of the leg is arranged at an angle to the second end of the leg so as to transmit forces between the main rotor system and the airframe; and
a bracket connected to a central portion of the leg, a portion of the bracket extending within an opening formed between the leg and the airframe, the bracket including a notch configured to receive the first servo, wherein when the first servo is positioned within the notch, a free end of the first servo is operably coupled to the first stationary swashplate and the leg reacts forces generated by the first servo into the main rotor system and the airframe; and
wherein operation of the first servo adjusts a pitch of the at least one first blade via the first stationary swashplate.

US Pat. No. 10,112,700

MULTI-MODE MOBILITY MICRO AIR VEHICLE

Orbital Research Inc., C...

1. A multi-mode mobility micro air vehicle (MAV) self-containedly comprising:an aerodynamic body capable of flight, the surface of the aerodynamic body having aerodynamic controls;
an aerodynamic propulsion system; and
at least one retractable leg adapted to deploy from an initial position enclosed within the aerodynamic body, and thereafter cyclically extend and contract under power to effect a directed hopping motion in conjunction with the aerodynamic propulsion system and the aerodynamic controls
wherein the multi-mode mobility MAV is capable of flying, safely landing, and hopping to a new orientation or position on the retractable leg.

US Pat. No. 10,112,699

METHOD OF PRELOADING AN AIRCRAFT ASSEMBLY, A PRELOADING TOOL AND AN AIRCRAFT ASSEMBLY

Safran Landing Systems UK...

1. A method of preloading an aircraft assembly for fitting a preloading linkage, the aircraft assembly comprising:a strut mounting joint;
a landing gear strut movably coupled to the strut mounting joint so as to be movable between a deployed condition, for take-off and landing, and a stowed condition for flight, the landing gear strut including a first link attachment joint arranged to be coupled to a first fitting of the preloading linkage;
a second link attachment joint arranged to be coupled to a second fitting of the preloading linkage; and
a first tool attachment joint mechanically coupled to the landing gear strut to define a load path between the first tool attachment joint and the strut;
the method comprising:
actuating a variable length preloading tool coupled between the first tool attachment joint and an anchor point having a known spatial relationship with respect to the aircraft assembly to cause the tool to change from:
a first extension state in which the landing gear strut is in a default, deployed position and where the distance between the first link attachment joint and the second link attachment joint is a default distance, to
a second extension state in which the landing gear strut is moved from the default, deployed position and where the distance between the first and second link attachment joints substantially corresponds to the preloaded distance between the first and second fittings of the preloading linkage.

US Pat. No. 10,112,684

SELF SUPPORTING CANOPY

GOODRICH CORPORATION, Ch...

1. An inflatable canopy assembly, comprising: an inflatable canopy cover; and a tunnel structural system integrated into said inflatable canopy cover, wherein said tunnel structural system provides a frame structure to said inflatable canopy assembly and comprises base tunnels extending along a perimeter of a raft, structural tunnels extending from said base tunnels, and an upper base tunnel providing a height support for said inflatable canopy cover, said structural tunnels intermediate said base tunnels and said upper base tunnel.

US Pat. No. 10,112,662

TRACK ROLLER FRAME ASSEMBLY FOR TRACK TYPE MACHINES

Caterpillar SARL, Geneva...

1. A track roller frame assembly for a track type machine, comprising:a first track roller frame,
a second track roller frame, the first track roller frame slidably received in the second track roller frame, the second track roller frame having an outer surface and an opening; and
an assembly for adjusting a gap between the first track roller frame and the second track roller frame, the assembly for adjusting the gap including:
a first plate coupled to the outer surface of the second track roller frame;
a resilient pad extending through the opening of the second track roller frame and abutting the first plate and the first track roller frame; and
one or more shims arranged between the first plate and the second track roller frame.

US Pat. No. 10,112,659

UTILITY VEHICLE WITH CARGO BED

KAWASAKI JUKOGYO KABUSHIK...

1. A utility vehicle comprising:a chassis; and
a cargo bed disposed behind a riding space,
the cargo bed being located above the chassis and having a bottom wall portion on which a cargo is placed, and
an entirety of the bottom wall portion extending so as to be inclined downward toward a rear side in a normal position of the cargo bed where the cargo bed is located on the chassis and the utility vehicle is supported on a horizontal surface.

US Pat. No. 10,112,650

VEHICLE FRAME ASSEMBLY

Honda Motor Co., Ltd., T...

1. A vehicle frame assembly comprising:a main frame part including a side sill extending in a longitudinal direction of the vehicle frame assembly, the side sill having a generally C-shaped cross-section with a top wall, a bottom wall, an inboard sidewall interconnecting the top and bottom walls, and an open outboard sidewall; and
a rear frame part secured to the main frame part and including a rear frame member extending in the longitudinal direction, the rear frame member having a generally U-shaped cross-section with an inboard sidewall, an outboard sidewall, a bottom wall interconnecting the inboard and outboard sidewalls, and an open top wall,
wherein the inboard sidewall at a rearward end portion of the side sill includes a section bulging away from the open outboard sidewall in a lateral direction of the vehicle frame assembly, and the inboard sidewall of the rear frame member is secured to the bulging section of the side sill,
wherein the rearward end portion of the side sill and the rear frame member are arranged to have an overlapping configuration along each of the inboard sidewall, outboard sidewall and bottom wall of the rear frame member.

US Pat. No. 10,112,641

GUIDE TUBE FOR A STEERING SHAFT AND METHOD FOR PRODUCING SAME

Adval Tech Holding AG, N...

1. A guide tube for the rotatable mounting of a steering spindle of a motor vehicle,wherein the guide tube is rolled cylindrically from a single metal sheet portion and is connected at an axial contact point, and
wherein the guide tube has elements for the definably axially displaceable fastening in a bearing unit,
wherein the elements are configured in the form of at least two beads, which are distributed over the circumference, are axially running, and are formed circumferentially on both sides by ribs that broaden the cylinder circumference, which beads are shaped in the metal sheet portion.

US Pat. No. 10,112,638

SELF-ADJUSTING BALANCED MULTI-PURPOSE TRANSPORT CARRIER

1. A self-adjusting balanced transport carrier for carrying a load comprising:(a) a harness belt for attaching to a user;
(b) a mono-wheel;
(c) a frame comprising a first and second side rail, wherein said first and second side rails comprises a front end, a rear end, and a midpoint;
(d) a platform;
(e) a stop plate; and
(f) a pair of crisscross shoulder straps comprising a first strap and a second strap, wherein the first strap is attached to the first side rail at a first point of attachment and a second point of attachment and the second strap is attached to the second side rail at a first point of attachment and a second point of attachment, wherein said crisscross shoulder straps are not attached to the harness belt.

US Pat. No. 10,112,603

FRONT END MOTOR-GENERATOR SYSTEM AND HYBRID ELECTRIC VEHICLE OPERATING METHOD

Bendix Commercial Vehicle...

1. A front end motor-generator controller for control of a hybrid electric arrangement for an internal combustion engine of a vehicle having an integrated switchable coupling at a front of the engine arranged to selectively engage a front end of an engine crankshaft on an engine-side of the coupling to an engine accessory drive on a drive-side of the integrated switchable coupling, comprising:a front end motor-generator control module programmed to
determine an operating state of the vehicle based on operating state information received from at least one of a vehicle sensor and another controller of the vehicle;
determine from the determined operating state a current operating priority, wherein the current operating priority is one of:
meeting a safety requirement, the safety requirement including at least a requirement to maintain a first amount of stored compressed air for safe operation of a pneumatic brake system of the vehicle,
meeting an energy store requirement, the energy store requirement including at least a requirement to maintain a state of charge of an energy store above first state of charge level,
meeting an engine operating requirement, the engine operating requirement including at least a requirement to maintain an engine operating parameter within an operating limit, the engine operating parameter including at least an engine coolant temperature, and
meeting a driver comfort requirement, the driver comfort requirement including at least a requirement to maintain a climate condition of a passenger compartment of the vehicle in a desired temperature range;
select an operating mode of the hybrid electric arrangement based on the determined current operating priority, wherein the determined operating mode is one of a plurality of motor-generator operating modes, the plurality of motor-generator operating modes including at least one of an electrical energy generating mode, an engine accessory drive torque generating mode, a supplemental engine torque generating mode, and an idle mode; and
control operation of the motor-generator and the integrated switchable coupling to implement the selected operating mode, including commanding the integrated switchable coupling into one of an engaged state in which torque is transferable between the motor-generator and the crankshaft, and a disengaged state in which the motor-generator is disengaged from the crankshaft and torque from the motor-generator is transferable to the drive-side of the integrated switchable coupling to drive the engine accessory drive to drive at least one engine accessory.

US Pat. No. 10,112,576

SEATBELT RETRACTOR

Joyson Safety Systems Acq...

1. A refractor assembly for a seatbelt system having a webbing for restraining a secured occupant, the retractor comprising:a spool configured to wind and unwind the webbing about an axis of rotation, the spool includes a side with an opening therein;
a collar including an outer surface and an inner surface, the outer surface configured to engage the opening;
a locking base configured to operatively engage the inner surface; and
an energy absorbing member configured to provide a progressive level of load resistance via compression of the energy absorbing member in a direction parallel to the axis of rotation upon relative rotation between the spool and the locking base.

US Pat. No. 10,112,574

BELT FITTING

ENSHU CO., LTD., Shizuok...

1. A belt fitting comprising:a main body member that is formed with an insertion hole through which a belt of a vehicle seatbelt device is inserted, and that is attached to the vehicle at a portion that is not formed with the insertion hole; and
a projecting portion that is provided integrally at the main body member, that forms an outer peripheral face of the insertion hole, and that a leading side portion of the projecting portion extends out toward a radial direction outer side of the insertion hole and is apart from a base side portion of the projecting portion in an entire circumferential direction of the insertion hole; wherein
a straight portion is provided in the base side portion of the projecting portion at a side face opposite the insertion hole along the entire circumferential direction of the insertion hole, the straight portion being straight along a plane perpendicular to a circumferential direction of the insertion hole.

US Pat. No. 10,112,532

TELL-TALE LIGHTING DESIGN OPTIMIZATION FOR INSTRUMENT PANEL CLUSTERS

N.S. International, LTD.,...

1. An improved instrument cluster with reduced light leakage, comprising:an outer panel, said outer panel having at least one aperture to accommodate at least one gauge;
an appliqué configured to have an instrument display, said instrument display further including at least one telltale; said telltale providing an indication of a vehicle status condition;
said appliqué overlying an inner panel, said inner panel configured with at least one projection extending substantially perpendicular to said applique;
said projections forming a light chimney between a circuit board and said appliqué, said circuit board equipped with at least one illumination source in a light chimney, said circuit board spaced apart from said inner panel projections, a light blocker positioned in said light chimney and proximal said illumination source, said light blocker projecting normal from each said inner panel projections; said light blocker further reducing light leakage from an adjacent light chimney.

US Pat. No. 10,112,522

FROZEN CONFECTION KIOSK AND LIQUID-DISPENSING ASSEMBLY FOR USE THEREWITH

Tikiz Franchising, LLC, ...

1. An apparatus comprising:a kiosk comprising a sidewall defining an interior chamber having a size suitable for accommodating a person therein;
a frozen confection forming device in the interior chamber;
a serving window formed through the sidewall and configured to allow a frozen confection to pass through the window from the interior chamber to outside the kiosk;
an elongated slot with a closed first end and an open second end formed in the sidewall;
a track extending adjacent the sidewall;
a carriage which engages and is movable back and forth along the track; with a portion of the carriage disposed within the slot and wherein the portion of the carriage within the slot is movable into and out of the slot through the open second end; and
a liquid-topping dispenser assembly which comprises a support and a plurality of liquid-dispensing faucets carried by the support and operable by a person outside the kiosk; wherein the dispenser assembly is mounted on the carriage so that the dispenser assembly is movable back and forth with the carriage.

US Pat. No. 10,112,518

WORK VEHICLE WITH FOLD-OUT TIPPING EDGE

Wacker Neuson Linz GmbH, ...

9. A skip apparatus for a working vehicle, the skip apparatus comprising:a skip that is pivotable upward about a carrying axle and that has a pouring edge via which pourable material is able to be poured out of the skip; and
an emptying device which is pivotable relative to the skip about a pivot axle during a pivoting movement, the pivot axle being provided on the skip;
wherein
the emptying device has an inlet side and an outlet side;
the inlet side is arranged in a region of the pouring edge such that the pourable material, which is poured out of the skip via the pouring edge, passes into the emptying device via the inlet side; and wherein
the pivoting movement of the emptying device is guided in a defined manner by a guiding device, wherein a carrying device supports the carrying axle and the skip, and wherein the guiding device is coupled to the emptying device and to the carrying device via respective axles or joints.

US Pat. No. 10,112,499

SYSTEM AND METHOD FOR CONTROLLING CHARGING AND DISCHARGING OF ELECTRIC VEHICLE

State Grid Chongqing Elec...

1. A charging and discharging control system for an electric vehicle, characterized in that it includes a total control platform and a detecting module;said total control platform including a communication module, a data storage and management module, a dual-level optimization control module, and a power distribution control module;
said communication module for achieving two-way interaction between the total control platform and the electric vehicle, transmitting requirements for a charging and discharging service to a user of the electric vehicle, transmitting the total control platform willingness of the electric vehicle to participate in the charging and discharging service and real-time data about battery status, and performing data transmission and communication with a power control module in a charger;
said data storage and management module for storing and managing data related to charging and discharging of the electric vehicle, assigning power command values about charging and discharging of the electric vehicle to related interface variables by protocol to be invoked by the total control platform;
said dual-level optimization control module for determining in real time start-stop and power output conditions of a generator set in a wide-area power system, computing in real time decision variables of charging and discharging power of the electric vehicle which participates in a grid charging and discharging service, determining a number of electric vehicles which participate in the charging and discharging service and a real-time charging and discharging power by integrating and analyzing decision variables and data of the generator set;
said power distribution control module for controlling the charging and discharging power of the electric vehicle after receiving power control commands from the communication module;
said detecting module for detecting in real time power battery state of the electric vehicle connected to the grid and sending detection data to the total control platform through the communication module;
wherein the charging and discharging control system for the electric vehicle is used to perform the following steps:
Step 1: reading in real time load conditions of each load point in a wide-area power system, analyzing electrical energy demand of the wide-area power system in a next period of time; reading in real time related data of an electric vehicle which is willing to participate in a charging and discharging service of a power system, and storing and managing data through a data storage and management module;
Step 2: determining a total cost of transfer of electrical energy from a generator set i to a wide area network during a period of time t;
Step 3: determining a total cost of participation of an electric vehicle j in the charging and discharging service and screening out a dispatchable electric vehicle aggregator;
Step 4: obtaining a combination of the generator set and the electric vehicle which participates in the charging and discharging service according to Step 2 and Step 3;
Step 5: reading in real time data related to a power battery of the electric vehicle which participates in the charging and discharging service and calculating charging and discharging command values of the electric vehicle which participates in a grid charging and discharging service; and
Step 6: storing and then outputting charging and discharging power commands of the electric vehicle which participates in the charging and discharging service,
wherein said Step 2 specifically includes substeps of:
Step 21: monitoring in real time running status of the generator set and measuring whether the generator set i can participate in power dispatching in a future period of time t;
Step 22: determining a fuel cost Cfig(pi(t)) of the generator set i based on historical data on power generation efficiency and fuel cost of the generator set;
Step 23: determining an emission cost Ceig(pi(t)) of the generator set i based on historical data on carbon emission factor and carbon emission cost of the generator set;
Step 24: measuring and dispatching network loss of electric quantity Pi(t) during the process of transmission through simulation of transmission from the generator set i to load points of wide area network, further calculating a cost of network loss Clig(pi(t));
Step 25: determining a total cost Cjg(P j(t))of transmission of electrical energy from the generator set i to wide area network during the period of time t based on the fuel cost, emission cost, and network loss cost of the generator set, the total cost having functions of:

wherein pi(t) represents a dispatched electrical quantity when the generator set participates in dispatching of the electrical quantity, Pimin represents a minimum dispatched electrical quantity, Pimax represents a maximum dispatched electrical quantity, pidemand(t) represents an electrical energy demand of the power system, and pinetwork loss (t) represents loss of electrical energy from the generator set to load points of the grid during the process of transmission.

US Pat. No. 10,112,492

METHOD FOR CONTROLLING A DC/DC VOLTAGE STEP-DOWN CONVERTER

CONTINENTAL AUTOMOTIVE FR...

1. A method for controlling a DC/DC voltage step-down converter, called a “buck converter”, configured to supply an output voltage at a regulated value from an electrical source, comprising:providing said voltage step-down converter including an inductive component, one terminal of which is connected to the electrical source via a regulating switch, while another terminal is connected to a capacitive component at an output of said voltage step-down converter;
regulating the output voltage by alternating intervals, called “connection intervals”, during which the regulating switch is in an on state, with intervals, called “disconnection intervals”, during which said regulating switch is in an off state; and
switching the regulating switch from the on state to the off state when the value of the output voltage reaches a disconnection threshold, and from the off state to the on state when the value of the output voltage reaches a connection threshold,
wherein the disconnection threshold has a variable value which decreases progressively, during each connection interval, from a maximum value of said disconnection threshold which is greater than a maximum value of the connection threshold.

US Pat. No. 10,112,487

SYSTEM AND METHOD OF MAINTAINING HIGH VOLTAGE BATTERY CHARGING WITH DETECTED AUXILIARY BATTERY FAULT

Ford Global Technologies,...

1. An electric vehicle (EV) auxiliary battery current fault system, comprising:a battery maintenance electronic control unit (ECU);
an auxiliary battery sensor communicatively coupled to an auxiliary battery and the battery maintenance ECU;
a voltage sensor communicatively coupled to a main battery and the battery maintenance ECU;
a battery isolation switch;
a low voltage bus communicatively coupled to at least one of the main battery, the auxiliary battery, the battery isolation switch, and a DC to DC converter; and
an auxiliary battery sensor and controller communicatively coupled to the auxiliary battery and the battery maintenance ECU.

US Pat. No. 10,112,481

POWER TRANSFER UNIT (PTU) ASSEMBLY WITH CYLINDER

BorgWarner Inc., Auburn ...

1. A power takeoff unit for an automotive vehicle being a normally front-wheel drive vehicle and convertible to an all-wheel drive vehicle comprising:an input shaft supported in a housing, said input shaft being torsionally connected with a transmission of said vehicle;
an output shaft concentric with said input shaft, said output shaft being torsionally connected with rear wheels of said vehicle;
a shift collar to selectively connect said input shaft with said output shaft;
a shift fork to translate said shift collar, said shift fork being slidably mounted in said housing and said shift fork having a main body with a bore generally parallel with said input shaft;
a cylinder connected with said housing;
a piston slidably mounted within said cylinder; and
a headed fastener with a shank extending through said shift fork main body bore, said fastener head engaging an end of said shift fork and said fastener shank being threadably engaged with said piston to capture said shift fork with said piston.

US Pat. No. 10,112,478

METHOD AND SYSTEM TO DETERMINE A RANGE FOR A VEHICLE

1. A method for estimating a range of a distance that a vehicle may travel without refueling, wherein said vehicle comprises a combustion engine and a fuel supply system associated with said combustion engine, wherein the vehicle also comprises a first main tank for receiving fuel, and a first fuel pump for transfer of fuel from said first main tank to said fuel supply system, wherein the method comprises:based on data relating to the road ahead of the vehicle and a first measure of a residual fuel in said first main tank, estimating a range for said vehicle;
based on said data relating to the road ahead of the vehicle, controlling a required fuel reserve.

US Pat. No. 10,112,464

ROLL-UP TONNEAU COVER SYSTEM WITH GROOVED SIDE RAILS

Retrax Holdings, LLC, Gr...

1. A tonneau cover system for a truck cargo box including a forward end and a rear end, and first and second side walls therebetween, the tonneau cover system comprising:first and second side rails attachable along the first and second side walls, respectively, of the cargo box, each side rail having a forward end comprising a rail track having a support surface and a plurality of linear grooves extending longitudinally along the side rail, the support surface and grooves having corresponding triangular cross-sectional shapes, the support surface providing a plurality of contact surfaces, and a one-piece metal component forming the rail track, including the grooves, the support surfaces, and the contact surfaces;
a storage track attachable adjacent the forward end of the cargo box with the storage track in alignment with the rail track;
a roll-up tonneau cover comprising a plurality of slats pivotally connected together, each slat having first and second end caps including a bearing surface that engages directly against the contact surfaces of the support surface of the first and second side rails, respectively, and a one-piece polymer component forming each end cap, including the bearing surface, and the bearing surface of the end caps being slidable against and along the contact surfaces of the support surfaces between a storage arrangement in which the slats are supported by the storage tracks to provide access to the cargo box, and a deployed arrangement in which the slats are supported by the support surfaces to cover the cargo box.

US Pat. No. 10,112,453

SHOCK ABSORBER

SHOWA CORPORATION, Gyoda...

1. A shock absorber comprising:a cylinder that houses a liquid;
a partitioning portion that is provided in the cylinder so as to be movable in an axial direction and partitions a space in the cylinder into a first liquid chamber and a second liquid chamber;
a channel forming portion that forms a channel for a liquid flowing across the first liquid chamber and the second liquid chamber in conjunction with movement of the partitioning portion;
a valve that opens and closes a channel port of the channel in the channel forming portion to control a flow of the liquid through the channel;
a pressure chamber that houses the liquid and that enables a pressure of the liquid that has been housed to be changed; and
a pressing portion that uses a pressure in the pressure chamber to press the valve in a direction in which the valve closes the channel port, wherein the pressing portion comprises a contact member that contacts the valve and a pressure chamber forming member that forms the pressure chamber along with the contact member;
an advancing and retracting member that advances and retracts with respect to the pressure chamber to change the pressure of the liquid in the pressure chamber, wherein the advancing and retracting member comprises a shaft and the pressure of the liquid in the pressure chamber is configured to be changed by changing a volume of a portion of the shaft that is placed in the pressure chamber.

US Pat. No. 10,112,449

BALL HITCH WITH LOCKING SWIVEL AND RAMP

1. A socket apparatus for connecting a towed vehicle to an upward extending hitch ball attached to a towing vehicle by lowering the socket apparatus onto the hitch ball, the apparatus comprising:a socket member defining a socket with an open bottom, and a rear end of the socket member adapted for attachment to the towed vehicle;
a ramp member attached to the socket member with a forward end of a lower surface of the ramp member located below a rear edge of the socket, the lower surface of the ramp member sloping downward and rearward from the forward end of the ramp member to a rearward end of the ramp member;
a securing mechanism movable from an open position, where the bottom of the socket is open to allow the hitch ball to enter the socket, to a closed position where the hitch ball is secured in the socket;
wherein an upper front edge of the ramp member is configured to substantially conform to an outer surface of the hitch ball such that when the hitch ball is fully inserted in the socket and the securing mechanism is in the closed position the hitch ball bears against the upper front edge of the ramp member when the towing vehicle tows the towed vehicle in a forward direction.

US Pat. No. 10,112,437

ELASTIC WHEEL FOR RAILWAY VEHICLES

CONSTRUCCIONES Y AUXILIAR...

1. An elastic wheel for railway vehicles, comprising:a tread;
a wheel center;
an axis (R) at the center of the wheel;
a retaining ring attached to the wheel center by means of attachment screws;
a V-shaped housing delimited by the tread, the wheel center and the retaining ring, for the insertion of an elastomer, in which the elastomer is formed by a plurality of V-shaped elastic blocks and the elastomer is compressed by the retaining ring towards the axis (R) of the wheel, the V-shaped housing comprising:
a vertex,
first and second inclined sections on which the V-shaped-elastic blocks are supported, the first and second inclined sections being connected at the vertex and extending away from the vertex in respective first and second directions, the first inclined section formed by an inclined surface of the retaining ring, the second inclined section formed by an inclined surface the wheel center,
a first oblique wall joined to the first inclined section, the first oblique wall formed by an oblique surface of the retaining ring,
a second oblique wall joined to the second inclined section, the second oblique wall formed by an oblique surface of the retaining ring,
a first vertical wall joined to the first oblique wall, the first vertical wall being perpendicular to the axis, the first vertical wall being formed by a vertical surface of the retaining ring,
a second vertical wall joined to the second oblique wall, the second vertical wall being perpendicular to the axis, the second vertical wall being formed by a vertical surface of the wheel center,
a first horizontal wall joined to the first vertical wall, the first horizontal wall being parallel to the axis, the first horizontal wall being formed by a first horizontal surface of the tread,
a second horizontal wall joined to the second vertical wall, the second horizontal wall being parallel to the axis, the second horizontal wall being formed by a second horizontal surface of the tread, and
a radially inwardly projecting portion between the first and second horizontal walls, between the first and second vertical walls, and between the first and second oblique walls, the radially inwardly projecting portion formed by a projecting surface of the tread,
wherein:
the first oblique wall and the retaining ring are located on a first side of a line that intersects the axis (R), is perpendicular to the axis (R), and passes through the vertex, and the second oblique wall is located on a second side of the line opposite the first side,
each of the first and second oblique walls forms an angle (?) of between 48° and 52° with respect to the axis (R) of the wheel,
the first inclined section is located on the first side of the line and disposed between the vertex and the first oblique wall,
the second inclined section is located on the second side of the line and disposed between the vertex and the second oblique wall, and
each of the first and second inclined sections forms an angle (?) of between 2° and 10° with respect to the axis (R) of the wheel.

US Pat. No. 10,112,436

CENTRE-LOCK ATTACHMENT ARRANGEMENT FOR COMPOSITE WHEELS

Carbon Revolution Limited...

1. A centre-lock attachment arrangement configured to attach at least one composite wheel to a mount using a centre-lock fastener and a centre-lock fastening nut which can be fastened on the centre-lock fastener, the composite wheel including a central attachment area having a composite wheel central attachment aperture through which the centre-lock fastener is inserted, and a plurality of composite wheel fastener apertures annularly spaced around the composite wheel central attachment aperture, the centre-lock attachment arrangement including:a front element including a front element outer engagement surface configured to engage the centre-lock fastening nut, and a front element inner engagement surface configured to engage with an outer side of the central attachment area of the composite wheel, the front element including a front element attachment aperture through which the centre-lock fastener is inserted and a plurality of front element fastener apertures annularly spaced around the front element attachment aperture, said front element fastener apertures being complementary to the composite wheel fastener apertures of the central attachment area of the composite wheel;
a backing element including a backing element outer engagement surface configured to face the mount, and a backing element inner engagement surface configured to engage with an inner side of the central attachment area of the composite wheel, the backing element including a backing element attachment aperture through which the centre-lock fastener is inserted and a plurality of backing element fastener apertures spaced apart around the backing element attachment aperture, said backing element fastener apertures being complementary to the composite wheel fastener apertures of the central attachment area of the composite wheel; and
a plurality of elongate fasteners configured to be received through the plurality of front element fastener apertures and the plurality of backing element fastener apertures which are aligned, the plurality of elongate fasteners configured to clamp the front element and the backing element over and around the central attachment area of the composite wheel.

US Pat. No. 10,112,434

SHADOW IMAGE SECURITY FEATURE

Entrust Datacard Corporat...

1. A security document comprising:a core;
a portrait image of an intended holder of the security document applied to the core, the portrait image is visible on the security document;
a window area in the core, the window area includes a metalized foil layer disposed between two transparent layers;
a laser ablated image formed in the metalized foil layer in the window area, the laser ablated image is separate from the portrait image, the laser ablated image is of the intended holder of the security document, the laser ablated image being transparent, and the laser ablated image is visible from a front of the security document and visible from a rear of the security document.

US Pat. No. 10,112,432

SECURITY DEVICE

DE LA RUE INTERNATIONAL L...

1. A security device comprising:a first transparent coloured element disposed in a first region of the device, the first transparent coloured element defining a first surface;
a second transparent colored element disposed in the first region of the device and being adjacent to the first transparent coloured element, the second transparent coloured element defining a second surface;
a first optically variable effect generating relief microstructure extending across the first surface of the first transparent coloured element and the second surface of the second transparent coloured element;
a third transparent coloured element disposed in a second region of the device, the second region being laterally offset and spaced apart from the first region, the third transparent coloured element defining a third surface;
a second optically variable effect generating relief microstructure extending across the third surface of the third transparent coloured element; and
a reflection enhancing layer extending: (i) across the first optically variable effect generating relief microstructure and following a first contour of the first optically variable effect generating relief microstructure, and (ii) across the second optically variable effect generating relief microstructure and following a second contour of the second optically variable effect generating relief microstructure, wherein
the reflection enhancing layer extending across the first and second optically variable effect generating relief structures are formed of an identical material, and
the reflection enhancing layer is provided in discrete portions in the first region and second region respectively.

US Pat. No. 10,112,371

FLOOR UNDERLAYMENT

MP Global Products, L.L.C...

1. A method of installing a laminate wood floor over a subflooring, comprising:providing a layered melted portion-foam composition including a foam sheet having a melted portion integrally formed, the foam sheet being a polyethylenic resin having a thickness between about 0.03 to about 0.25 inches and a density of about 1 to about 5 pounds per cubic foot, the melted portion being a polyethylenic resin having a thickness of about 1 to about 10 mils;
placing the layered melted portion-foam composition over the subflooring; and
laying the laminate wood floor over the layered melted portion-foam composition.

US Pat. No. 10,112,362

ALVEOLAR MULTILAYER STRUCTURE HAVING A METAL COATING

AKX, SA, Alfortville (FR...

1. A thermally insulating structure, comprising:a multi-layer film including a first polymer layer and a metallized layer;
a second polymer layer joined to the multi-layer film; wherein a portion of the multi-layer film and a portion of the second polymer layer are joined at a plurality of disjoint zones positioned along rectilinear lines and disposed in an array, wherein the plurality of disjoint zones define a set of cells wherein each cell of the set of cells has four openings positioned between adjacent disjoint zones, wherein the four openings enable communication between each cell of the set of cells and four adjacent cells of the set of cells;
wherein the thermally insulating structure comprises:
a flattened state wherein the second polymer layer is compressed against the multi-layer film;
a deployed state wherein the second polymer layer is separated from the multi-layer film by a volume of gas while remaining joined at the plurality of the disjoint zones; and
at least one side edge that remains open to an ambient environment in both the flattened state and the deployed state.

US Pat. No. 10,112,355

SPORT BALL CASING WITH THERMOPLASTIC REINFORCING MATERIAL

NIKE, Inc., Beaverton, O...

1. A method of manufacturing a sport ball comprising:providing a plurality of casing panels including a first panel and a second panel;
the first panel having a first surface and an opposite second surface, the first surface formed, at least in part, of a first thermoplastic material, and the second surface including a first reinforcing layer formed of a second thermoplastic material, wherein the first panel includes a first flange area forming a first edge portion of the first panel;
the second panel having a third surface and an opposite fourth surface, the third surface formed, at least in part, of the first thermoplastic material, and the fourth surface including a second reinforcing layer formed of the second thermoplastic material, wherein the second panel includes a second flange area forming a second edge portion of the second panel;
turning the first flange area away from the first surface of the first panel;
turning the second flange area away from the third surface of the second panel;
abutting the first flange area and the second flange area; and
joining the first panel to the second panel by:
welding the first thermoplastic material in the first flange area to the first thermoplastic material in the second flange area, thereby forming a seam between the first panel and the second panel; and
welding the first reinforcing layer to the second reinforcing layer, thereby forming a continuous reinforcing strip that extends across the seam.

US Pat. No. 10,112,349

PLACEMENT OF PREPREG TOWS IN HIGH ANGLE TRANSITION REGIONS

The Boeing Company, Chic...

1. A method of placing a prepreg tow on a substrate having a bend with a curvature extending over a transition region in the substrate, wherein the bend subtends a first angle defined between a first imaginary line having a first endpoint at a first side of the transition region and a second imaginary line having a second endpoint at a second side of the transition region, wherein a vertex of the first imaginary line and the second imaginary line is located at a point on a reference axis that is perpendicular to an apex of the bend, and wherein the point corresponds to about mid-way along a distance extending along the transition region between the first endpoint and the second endpoint, the method comprising:laying the prepreg tow with at least a first section of the prepreg tow and a second section of the prepreg tow within the transition region, wherein the first section extends along a first portion of the transition region and has a first degree of curvature that is less than the first angle, and wherein the second section extends along a second portion of the transition region and has a second degree of curvature that is less than the first angle;
programming a numeric controller; and
using the numeric controller to control an advanced fiber placement machine, wherein laying the prepreg tow is performed by the advanced fiber placement machine.

US Pat. No. 10,112,348

FIBER PLACEMENT SYSTEM

Ingersoll Machine Tools, ...

1. An automatic fiber placement system, comprising:a gantry including a cross rail between a first column and a second column, the cross rail extending past the second column;
a fiber placement head carried by the gantry;
wherein the gantry provides movement of the fiber placement head between at least a first working zone between the first and second columns and a second working zone located outside the second column;
wherein the first working zone is configured to provide a first mold structure;
wherein the second working zone is configured to provide a second mold structure;
wherein the fiber placement head is configured to apply fiber tows to the first mold structure when the fiber placement head is in the first working zone; and
wherein the fiber placement head is configured to apply fiber tows to the second mold structure when the fiber placement head is in the second working zone.

US Pat. No. 10,112,341

THREE-DIMENSIONAL OBJECT MANUFACTURING METHOD

MIMAKI ENGINEERING CO., L...

1. A three-dimensional object manufacturing method including a 3D object forming step of forming a three-dimensional object by discharging a UV curing type ink, carrying out UV irradiation on the discharged ink to form a layer, and overlapping a plurality of the layers; whereinthe 3D object forming step includes
with a model material and a support material adjacent to each other, the model material serving as the ink to become at least a part of the three-dimensional object and the support material serving as the ink that is at least disposed on a lower side of the model material in a vertical direction to support the model material,
a step of simultaneously planarizing a surface of the model material and a surface of the support material with a planarizing member before curing;
the three-dimensional object manufacturing method further includes
a support material removing step of removing the support material from the three-dimensional object after the 3D object forming step; and
a whitening suppressing solution applying step of applying a whitening suppressing solution for suppressing whitening of a surface of the three-dimensional object on the surface after the support material removing step; and
the whitening suppressing solution is a liquid containing:
a transparent liquid that makes the support material transparent, and
a film forming substance that forms a film on the surface by drying of the transparent liquid.

US Pat. No. 10,112,332

HEATING DEVICE OF INJECTION MOLDING MACHINE

NISSEI PLASTIC INDUSTRIAL...

1. A heating device of an injection molding machine, the heating device comprising:a plurality of heaters being sequentially provided along an axial direction on an outer circumferential surface of at least one of a heating cylinder and an injection nozzle to heat at least one of the heating cylinder and the injection nozzle;
at least a first one of the plurality of heaters is positioned in a front portion and includes a first air cooling-capable heater;
at least a second one of the plurality of heaters is positioned in an intermediate zone and includes a second air cooling-capable heater; and
at least a third one of the plurality of heaters is positioned in a back portion and includes a third air cooling-capable heater;
wherein the first, second and third air cooling-capable heaters each includes one panel member, formed of a material having thermal conductivity, that is interposed between the part of at least the first, second and third heaters and the outer circumferential surface of at least one of the heating cylinder and the injection nozzle, in which each of the first, second and third air cooling-capable heaters includes an air path for air cooling that is formed as a respective slit punched in the panel member and in which each of the first, second and third cooling-capable heaters includes an air outlet and an air inlet that are in communication with the respective slit for allowing air to be passed from an air supply, wherein air is supplied from the air supply to each of the first, second and third air inlets and through the respective slit formed in the panel member and the air exits through the air outlet portion for cooling the heating device.

US Pat. No. 10,112,325

CONCRETE FORMING SYSTEMS AND METHODS

Goss Construction, Inc., ...

1. A method of forming a concrete spread footing in an excavation, the method comprising:providing a frame assembly comprising:
a frame configured to extend over the excavation from a first side of the excavation to an opposing second side of the excavation;
a form coupled to the frame, the form configured to define at least part of the shape of the concrete spread footing;
a reinforcement structure configured to reinforce the concrete spread footing, at least part of the reinforcement structure being disposed within the form; and
a template defining an inbed pattern over the form;
wherein the frame is configured to support the form and the reinforcement structure in suspension over the excavation;
wherein the frame comprises at least one attachment member configured to couple to the frame and the form, the at least one attachment member being disposed vertically below the template and spaced apart vertically from the template by a sufficient distance to allow workers' hands to access the space vertically between the at least one attachment member and the template.

US Pat. No. 10,112,316

STRAND ORIENTATION SYSTEM AND METHOD

Norbord Inc., Toronto (C...

1. A system for orienting elongate wood strands, comprising:a plurality of rotatable shafts that extend substantially perpendicular to a travel direction of a mat of the elongate wood strands, each rotatable shaft including axially spaced agitation members that extend radially away from the shaft; and
a vane set positioned vertically below a portion of at least one of the agitation members and the vane set including substantially parallel and stationary partitions with openings therebetween;
wherein each partition of the vane set has a length that is substantially parallel to the travel direction; and
wherein at least one stationary partition of the vane set has an upper edge thickness that is greater than a lower edge thickness of the same stationary partition such that an opening width between opposing faces of the at least one stationary partition and an adjacent partition is greater at a lower portion of the partitions than at an upper portion of the same partitions.

US Pat. No. 10,112,313

SHAVING DEVICE

Ruairidh Robertson, Sand...

1. A shaving device comprising:a handle;
a support member disposed about a first end of said handle, said support member comprising at least one arm extending outward from a yoke and a biasing magnet;
a blade cartridge retention frame coupled to said at least one arm and configured to pivot about a pivot axis, said blade cartridge retention frame comprising a blade cartridge retention frame magnet; and
a replaceable blade assembly comprising a blade assembly magnet and a blade assembly body having a face with a razor blade;
wherein said blade assembly magnet and said blade cartridge retention frame magnet are configured to create a repulsive magnetic force therebetween to releasably couple said replaceable blade assembly to said blade cartridge retention frame such that said razor blade extends along a razor blade longitudinal axis that is substantially parallel to said pivot axis; and
wherein said biasing magnet is configured to generate a repulsive magnetic force with both of said blade cartridge retention frame magnet and said blade assembly magnet to urge said replaceable blade assembly about said pivot axis towards an initial starting position relative to said at least one arm.

US Pat. No. 10,112,306

AUTO-REDIRECTING ROBOT AND THE METHOD THEREOF

1. An auto-redirecting robot, comprising:a main body;
a control module, wherein said control module is disposed in the main body;
a plurality of driving modules, wherein the plurality of driving modules are disposed in the sides of the main body, characterized in that the control module directs the plurality of driving modules, so that the plurality of driving modules guide the main body to move alongside an obstacle;
a plurality of signal transmitters, wherein the plurality of signal transmitters are disposed in the sides of the main body, characterized in that the plurality of signal transmitters keep sending out signals to the obstacle as the main body is moving alongside said obstacle;
a plurality of signal receivers, wherein the plurality of signal receivers are disposed in the sides of the main body, characterized in that the plurality of signal receivers receive bounced-back signals from the obstacle; and
two sensors, wherein the two sensors are disposed in two-sides of the main body respectively, characterized in that as the main body touches the obstacle and one of the sensors is activated, the control module redirects the plurality of driving modules for moving said main body away from the obstacle;
wherein the control module generates a signal characteristic change based on the bounced-back signals received by the plurality of signal receivers,
and characterized in that the control module generates a signal standard value based on said signal characteristic change and determines a keep-away distance based on the signal standard value,
and characterized in that the control module controls the plurality of driving modules for keeping said keep-away distance between the main body and said obstacle while the main body moves alongside the obstacle, so that the main body needs not to touch the obstacle repeatedly; and
wherein if properties of said obstacle change or the bounced-back signals are inconsistent with the signal standard value, the control module directs the plurality of driving modules for moving the main body towards the obstacle until one of the two sensors is activated by the obstacle, then the control module directs the plurality of driving modules for moving the main body away from the obstacle.

US Pat. No. 10,112,277

COMBINED TYPE ANGLE HEAD MILLING CUTTER FOR MACHINING MOUNTING FACES OF AXIAL BEARING

CITIC Dicastal CO., LTD.,...

1. A combined type angle head milling cutter for machining mounting faces of an axial bearing, comprising an angle head body, a lock nut, first slotted countersunk head screws, a first hexagon socket head cap screw, a first flat key, semicircle seal covers, first angular contact ball bearings, a cutter handle shaft lower adjusting pad, a cutter handle shaft, a cutter handle shaft upper adjusting pad, a bearing cover plate, a first bevel gear, a first spring washer, a second bevel gear, a bevel gear adjusting pad, an orientation shaft, cutter shaft inner-side seal covers, second hexagon socket head cap screws, a cutter shaft outer-side seal cover, a second slotted countersunk head screw, a small seal ring, a first shaft circlip, round nuts, flat washers, short cutter locating sleeves, long cutter locating sleeves, cutters, second flat keys, cutter adjusting pads, a cutter shaft end cover, a big rubber seal flat pad, a cylindrical gear, a second spring washer, a third flat key, an M10 hexagon thin nut, a transition cylindrical gear, a second shaft circlip, a left transition gear adjusting pad, a transition shaft end cover, a small rubber seal flat pad, a cylindrical drive gear, an M8 hexagon thin nut, a bearing retaining ring, a second angular contact ball bearing, a drive shaft, a drive gear adjusting pad, a right transition gear adjusting pad, a third angular contact ball bearing, a transition shaft, a transition shaft seal cover, an O-shaped rubber seal ring, a gear adjusting pad, a cutter shaft, a big seal ring, deep groove ball bearings and a rubber seal flat pad; characterized in that, eight cutters are installed on the cutter shaft, the cutters being set in a way that positions thereof are adjusted via the cutter adjusting pads, the short cutter locating sleeves and the long cutter locating sleeves, and the flat washers being placed on the outmost cutters and fixed by the round nuts; two ends of the cutter shaft being installed on the angle head body by the deep groove ball bearings, and the cutter shaft inner-side seal covers and the rubber seal flat pad being installed on two sides of the interior of the angle head body by the second hexagon socket head cap screws; the cutter shaft inner-side seal covers not only being set to position the deep groove ball bearings, but also stopping cutting fluid and dust from entering the interior of the angle head body via the big seal ring; the right side of the cutter shaft being sealed by the cutter shaft outer-side seal cover, the rubber seal flat pad and the small seal ring, the cylindrical gear being installed on the left side of the cutter shaft, the position of the cylindrical gear being adjusted via the gear adjusting pad, the second spring washer being installed and fixed by the M10 hexagon thin nut, the cutter shaft end cover and the big rubber seal flat pad being installed on the outer side of the angle head body, and thus the cutter shaft being sealed; the cutter handle shaft being butted with the spindle of a machine tool; the cutter handle shaft being installed on the angle head body via the pair of first angular contact ball bearings, and the position of the cutter handle shaft being adjusted via the cutter handle shaft upper adjusting pad; the first bevel gear being installed at the end part of the cutter handle shaft, the position of the first bevel gear being adjusted by the cutter handle shaft lower adjusting pad, and the first spring washer and the lock nut being used for fixing the first bevel gear for preventing loosening; the outer rings of the first angular contact ball bearings and the angle head body being fixed by the bearing cover plate, and the cutter handle shaft being sealed by two semicircle seal covers; the drive shaft being connected to the angle head body via the second angular contact ball bearing, and the position of the drive shaft being fixed by a shaft shoulder and the bearing retaining ring; the second bevel gear being installed on the right end of the drive shaft, and engaged with the first bevel gear for transferring power, and the position of the second bevel gear being adjusted by the bevel gear adjusting pad; the cylindrical drive gear being installed on the left end of the drive shaft, the position of the gear being adjusted by the drive gear adjusting pad, the gear being fixed by the M8 hexagon thin nut, and the spring washer being placed therebetween for preventing loosening; the transition shaft being connected to the angle head body via the third angular contact ball bearing, the transition cylindrical gear installed on the transition shaft being engaged with the cylindrical gear and the cylindrical drive gear, the position of the transition cylindrical gear being adjusted via the right transition gear adjusting pad, and the end part of the drive shaft being fixed by the second shaft circlip for preventing the drive shaft from axially moving; and the transition shaft end cover and the small rubber seal flat pad being installed on the outer side of the angle head body, the transition shaft seal cover and the O-shaped rubber seal ring being installed on the inner side of the angle head body, and the above four components being all used for sealing the transition shaft and preventing the entering of the cutting fluid.

US Pat. No. 10,112,272

MANUFACTURING METHOD OF VAPOR CHAMBER

Asia Vital Components Co....

1. A manufacturing method of vapor chamber, comprising steps of:providing a first board body and a second board body;
using mechanical processing to form a hooked section structure on one face of the first board body, the hooked section structure being defined as a capillary structure layer;
using mechanical processing to form a hook section structure as a support structure on one face of the second board body; and
correspondingly mating the first and second board bodies with each other to form a chamber, and make the hook section and the hooked section contact and hook and connect with each other and sealing the periphery of the first and second board bodies and vacuuming the first and second board bodies and filling therein a working fluid, so as to form a vapor chamber with a vacuum chamber and sealed periphery, such that the hook section contacts, hooks and connects with the hooked section to provide a drag effect for the first and second board bodies to avoid a thermal expansion problem taking place when the vapor chamber is heated.

US Pat. No. 10,112,265

DECORATING DEVICE AND DECORATING METHOD FOR VEHICLE INTERIOR COMPONENTS, AND VEHICLE INTERIOR COMPONENT

TRINITY INDUSTRIAL CORPOR...

1. A decorating device for decorating vehicle-interior components, of which a laser is irradiated onto the decorating surface of a resin compact or onto the decorating surface of a coat-layer formed on the resin compact to draw designs thereon that are made of the linear laser-processed part, and that the laser focal-point is shifted from the decorating surface so as to draw the designs, thus forming the gradation on a certain part of the whole design, with the decorating device being characterized in comprising a data-preparing device for preparing the drawing-data on a virtual decorating surface that is deformed so as to have a different curvature than the surface shape of the actual decorating surface, and that a laser-drawing device for forming the gradation by emitting a laser focused on the virtual decorating surface is based on the drawing-data prepared by the data-preparing device, thus conducting the laser-processing with the laser-focal point shifted from the actual decorating surface.

US Pat. No. 10,112,258

COAXIAL DISTANCE MEASUREMENT VIA FOLDING OF TRIANGULATION SENSOR OPTICS PATH

View, Inc., Milpitas, CA...

1. An apparatus configured for scribing an optical coating on a transparent substrate having a first side and a second side with the optical coating disposed on one of the first side and the second side, the apparatus comprising:a stage having one side and an opposing side, and an aperture through the stage;
a scribe laser having a focus lens, a scribe laser beam from the scribe laser, wherein the scribe laser is located on one side of the stage and the transparent substrate is located to the opposing side of the stage, wherein the scribe laser beam is configured to pass through the aperture in the stage to impinge upon the transparent substrate substantially orthogonally, and wherein the scribe laser beam is further configured to ablate the optical coating;
a first mirror attached to the opposing side of the stage;
a second mirror attached to the opposing side of the stage; and
a triangulation-based distance sensor attached to the opposing side of the stage and comprising a triangulation laser and a detector, the triangulation-based distance sensor configured such that a triangulation laser beam from the triangulation laser is emitted substantially parallel to the transparent substrate, impinges on and is reflected from the first mirror to impinge on the transparent substrate at a first acute angle of incidence measured with respect to a normal to the transparent substrate, is reflected from the transparent substrate at a second acute angle measured with respect to the normal to the transparent substrate to the second mirror, and is reflected from the second mirror to the detector,
wherein the apparatus determines a distance between the one of a first side and a second side of the transparent substrate with the optical coating and the focus lens of the scribe laser based on a measured position of the reflected triangulation laser beam on the detector, and
wherein a span of the first acute angle and the second acute angle is a third acute angle which is bisected by the scribe laser beam passing through the aperture in the stage.

US Pat. No. 10,112,257

COATING ABLATING APPARATUS WITH COATING REMOVAL DETECTION

General Lasertronics Corp...

1. A laser-based coating removal apparatus to remove a coating from a surface, wherein the surface comprises the coating and a substrate, the laser-based coating apparatus comprising:a. a laser source to provide a laser light for removing the coating from a target region, wherein the laser source fires the laser light at a first rate to the target region and a second rate to the target region different from the first rate, wherein the first rate and the second rate are selected to remove the coating from the surface;
b. a routing element coupled to the laser source and configured to direct the laser light onto the target region of the surface;
c. a detection element that detects whether the coating has separated from the substrate in the target region of the surface by inputting a signal received from the surface in the target region, wherein the signal comprises data indicating one or more properties of the surface selected from a group consisting of incandescence, acoustic signature, motion and chemical properties; and
d. a controller configured to adjust a current firing rate of the laser light based upon the signal received from the surface in the target region, and wherein the controller increases the current firing rate of the laser light from the first rate to the second rate at the target region when a current removal of the coating is detected at the target region, and wherein the target region is divided into a plurality of detection areas by the detection element and the current firing rate of the laser light is decreased to the first rate if the detection element fails to detect that the coating has separated from the substrate for a period of time and then the laser light is continuously fired as the firing rate is adjusted; wherein if the detection element detects that the coating has separated from the substrate in the target region for a period, the controller coupled to the detection element decreases an amount of energy per second directed onto the target region by the laser light from a non-zero preselected high value to a non-zero preselected low value; wherein the controller is able to adjust a length of the period based on the one or more properties of the surface in the target region.

US Pat. No. 10,112,252

WIRE FEEDER TENSIONER WITH DEFINITIVE SETTINGS

Illinois Tool Works Inc.,...

1. A welding wire feeder, comprising:a tensioner configured to pivot about a tensioner joint, wherein the tensioner comprises:
an adjustment knob comprising a discrete number of detents, wherein the adjustment knob comprises a helical surface adjacent an inner bore of the adjustment knob, wherein the detents are located along the helical surface;
a cup assembly about which a lower portion of the adjustment knob is disposed, the cup assembly comprising an inner bore that is coaxial with the inner bore of the adjustment knob;
a spring disposed axially between the adjustment knob and the cup assembly;
a tensioning post disposed within the inner bores of both the adjustment knob and the cup assembly, wherein the tensioner joint extends through a first end of the tensioning post; and
a pin extending from a second end of the tensioning post that is opposite the first end, wherein the pin is configured to align with the detents in the adjustment knob;
wherein rotation of the adjustment knob adjusts a compressive force transferred from a drive wheel to welding wire among a discrete number of compressive force settings that directly correspond to the discrete number of detents in the adjustment knob.

US Pat. No. 10,112,251

METHOD AND APPARATUS FOR PROVIDING WELDING TYPE POWER

Illinois Tool Works Inc.,...

1. A welding-type power supply comprising:a controller, having a preregulator control output and an output converter control output;
a preregulator disposed to receive a range of inputs voltages and to receive the preregulator control output, and to provide a preregulator output signal, wherein the preregulator includes a plurality of stacked boost circuits;
a preregulator bus, disposed to receive the preregulator output signal; and
an output converter, disposed to receive the preregulator bus and to receive the output converter control output, and to provide a welding type power output, wherein the output converter includes at least one stacked inverter circuit.

US Pat. No. 10,112,250

WELDING SOURCE AND AC-DC ARGON ARC WELDING MACHINE

SHENZHEN JASIC TECHNOLOGY...

1. A welding source connected between an input end of an AC and a welding workpiece, wherein the welding source comprises:a rectifying and wave-filtering unit configured for transforming an input AC into a high voltage DC;
a first inverter unit configured for inverting the high voltage DC outputted by the rectifying and wave-filtering unit into a high voltage high frequency AC;
a transformer configured for transforming the high voltage high frequency AC outputted by the first inverter unit into a low voltage high frequency AC; and
a hybrid inverter unit including a plurality of IGBTs integrated internally with FRDs and configured for rectifying and performing a second inverting process for the low voltage high frequency AC outputted by the transformer, when the welding workpiece needs a low voltage low frequency AC, the IGBTs controlled to be on-off by using PWM drive pulses; when the welding workpiece needs a low voltage DC, the drive signals of some of the IGBTs set to be high level and the drive signal of the other IGBTs set to be low level.

US Pat. No. 10,112,243

METHOD AND APPARATUS FOR FORMING A PROFILE GROOVE IN A KEY BLANK

WINLOC AG, Zug (CH)

1. A method of forming a profile groove in an elongated key blank having a key blade with opposite side surfaces, said method comprising:forming said profile groove in a surface of said key blank by means of a broaching tool with at least one tooth which is forced and guided longitudinally in parallel to said elongated key blank so as to cut out material from said key blank into a desired profile shape, corresponding to a cross-sectional shape of said at least one tooth, said profile groove extending in a predetermined area from a distal end of the key blade towards a grip portion of the key blade, while
at the same time holding said opposite side surfaces of the key blank between opposite holding surfaces of a fixture, causing a firm abutment and retaining action on the longitudinal side surface portions of the key blade located adjacent to and all along said profile groove being formed, whereby the key blank material adjacent to said profile groove is retained in a fixed state without being deformed during the broaching operation,
wherein said profile groove has at least one undercut portion defined by an inner bottom wall and an opposite wall on an inside of a ridge portion, an outside of which forms at least a part of said longitudinal side surface portions being held by said fixture during said broaching operation, and wherein said at least one undercut portion is extended into a configuration formed as a pocket having opposite side wall portions and a transverse end wall portion.

US Pat. No. 10,112,242

RAMPING INSERT HAVING NON-POSITIVE CUTTING GEOMETRY AND RAMPING TOOL

Iscar, Ltd., Tefen (IL)

1. A double-sided, indexable, non-positive ramping insert (14) having a 180-degree rotational symmetry about each of the first, second and third axes (X, Y, Z) of a three-dimensional Euclidean space, a first median plane (XP) defined by the second and third axes (Y, Z), a second median plane (YP) defined by the first and third axes (X, Z) and a third median plane (ZP) defined by the first and second axes (X, Y),the ramping insert (14) comprising two first surfaces (24) located on opposite sides of the first median plane (XP), and an insert peripheral surface (26) extending between the first surfaces (24) and intersecting each first surface (24) at a peripheral edge (28),
each first surface (24) comprising two raised corners (18a) and two lowered corners (38a), the raised corners (18a) being farther from the first median plane (XP) than the lowered corners (38a);
the insert peripheral surface (26) comprising two second surfaces (30) and two third surfaces (32) extending therebetween,
each first surface (24) comprising exactly two opposite cutting portions (36), each cutting portion (36) comprising:
a major cutting edge (16) formed at an intersection of the first and second surfaces (24, 30);
a corner cutting edge (18) at one of the raised corners (18a), and
a wiper edge (20) connected to the major cutting edge (16) via the corner cutting edge (18);wherein,each cutting portion (36) further comprises a ramping edge (22) extending transversely from the wiper edge (20) in a view parallel to the first axis (X); and
each third surface (32) comprises only two non-positive ramping relief surfaces (46), each ramping relief surface (46) extending from a respective ramping edge (22) towards, but not beyond, the first median plane (XP).

US Pat. No. 10,112,227

LARGE SCALE METAL FORMING CONTROL SYSTEM AND METHOD

ILLINOIS TOOL WORKS INC.,...

1. A heated line forming system comprising:a heating system configured to produce a heated line on a surface of a metal plate during a thermal forming process;
a cooling system configured to maintain a dry area for the heated line during the thermal forming process;
a liquid-filled bladder, wherein the metal plate is supported by the liquid-filled bladder during the thermal forming process; and
a control system configured to control at least one operational parameter of the heated line forming system to produce a resulting final shape of the metal plate consistent with a thermal forming plan executed by the control system.

US Pat. No. 10,112,214

ULTRA LOW REFLECTIVITY HYDROPHOBIC COATING AND METHOD THEREFOR

SURREY NANOSYSTEMS LIMITE...

1. A method of forming a low reflectivity hydrophobic coating on a substrate, including the steps of:providing in a reaction chamber a substrate having a layer of carbon nanostructures on the substrate,
supplying the reaction chamber with a coating precursor which includes a fluorocarbon, and
generating a plasma in the reaction chamber, in order to deposit a hydrophobic coating on at least a part of said layer of carbon nanostructures,
wherein either the plasma generation takes place in the absence of a source of hydrogen atoms, in which case the substrate is heated to at least 100° C., the power density of the plasma is not more than 0.1 Wcm?2 and the plasma is generated for a period from 3 to 12 minutes,
or the plasma generation takes place in the presence of a source of hydrogen atoms, in which case the power density of the plasma is not more than 0.2 Wcm?2 and the plasma is generated for a period from 5 to 14 seconds.

US Pat. No. 10,112,206

PUMP SYSTEMS, PUMP ENGINES, AND METHODS OF MAKING THE SAME

SILGAN DISPENSING SYSTEMS...

1. A pump system, comprising:a closure;
a pump engine attached to the closure, the pump engine comprising:
an accumulator having a product chamber;
an output cylinder defining a cavity therein, the accumulator removably attached to the output cylinder by interfitting snap-fit latch structures,
said output cylinder further comprising a base wall, a cylindrical wall extending off of the base wall, the cylindrical wall defining the cavity, a plug seal wall extending off of the base wall in a direction opposite the cylindrical wall, and a latch wall extending off of the base wall in the same direction as the plug seal wall;
an output stop within the cavity, said output stop being arranged to define an output volume;
a piston stem comprising a fluid lock at one end extending through the cavity and into the product chamber;
a piston stem flange extending off of a portion of the exterior surface of the piston stem within the cavity, said piston stem flange engaging with said output stop to generate said output volume; and
a piston seal in the product chamber and attached to the piston stem;
a head moveably attached to the closure and attached to an end of the piston stem;
a container attached to the closure, wherein at least a portion of the pump engine is positioned in an interior of the container; and
wherein application of an actuation force on the pump engine moves the fluid lock into the product chamber and exposes at least one input opening in the fluid stem to product in the product chamber allowing fluid to flow through the at least one input opening and release of the actuation force moves the fluid lock back to a rest position out of the product in the product chamber, creating a vacuum within the pump chamber and drawing product back into the product chamber through the at least one input opening.

US Pat. No. 10,112,205

SUBSTRATE PROCESSING APPARATUS AND SUBSTRATE PROCESSING METHOD

SCREEN Holdings Co., Ltd....

1. A substrate processing apparatus comprising:a transport robot that holds and transports a substrate having an at least partially circular outer periphery;
a substrate processor that performs processing on the substrate using a processing liquid;
a detector that detects a state of the substrate; and
a controller that controls operations of the transport robot, the substrate processor and the detector, based on pieces of schedule management information including a transport path of the substrate by the transport robot and contents of processing for the substrate, wherein
the transport robot transports the substrate along the transport path, carries in the substrate to the substrate processor, carries out the substrate after processing from the substrate processor, and carries in the substrate after processing by the substrate processor to the detector,
the substrate processor includes
a rotation holder that holds and rotates the substrate carried in by the transport robot, and
a processing liquid supplier that performs processing on an annular region of one surface by supplying the processing liquid to a peripheral portion of the one surface of the substrate rotated by the rotation holder,
the detector includes
a substrate holder that holds the substrate carried in by the transport robot, and
a position detector that detects a position of a peripheral edge of the substrate held by the substrate holder and a position of an inner edge of the annular region of the substrate held by the substrate holder,
the controller includes
a position deviation amount calculator that calculates a position deviation amount of a center of the substrate held by the rotation holder from a rotation center of the rotation holder, based on the position of the peripheral edge of the substrate detected by the position detector and the position of the inner edge of the annular region of the substrate detected by the position detector,
a position deviation direction determiner that specifies a relationship between an orientation of the substrate held by the rotation holder at a time of carrying of the substrate into the substrate processor by the transport robot and an orientation of the substrate held by the substrate holder at a time of carrying of the substrate into the detector by the transport robot, based on the pieces of schedule management information, and determines a position deviation direction of the center of the substrate held by the rotation holder from the rotation center of the rotation holder, based on the specified relationship, and
an adjustor that adjusts a carry-in operation of the substrate to the substrate processor by the transport robot such that a center of the substrate carried into the substrate processor after calculation of the position deviation amount and determination of the position deviation direction coincides with the rotation center of the rotation holder, based on the calculated position deviation amount and the determined position deviation direction.

US Pat. No. 10,112,199

CENTRIFUGE SAMPLE CONTAINER AND CLOSURE THEREFORE

Fiberlite Centrifuge, LLC...

1. A closure for attachment to a container body of a sample container configured for use in a centrifuge, the closure comprising:a top wall;
an annular skirt wall depending from the top wall and defining a maximum outer diameter, the annular skirt wall having a threaded inner surface configured to engage a container body;
a handle extending from the top wall and formed integrally with the top wall and the annular skirt wall, the handle including a central boss and at least two circumferentially spaced finger grips extending radially outward from the central boss,
wherein the at least two finger grips are axially offset from the top wall of the closure such that an axial space is defined between the top wall of the closure and a respective underside of each of the at least two finger grips at least at respective free terminal ends thereof, the finger grips and axial spaces being configured to enable grasping of the handle to facilitate lifting of the closure and sample container,
and further wherein the respective free terminal end of each of the finger grips is located so as not to extend beyond the maximum outer diameter; and
a plurality of circumferentially arranged gripping elements provided on the annular skirt wall and configured to be gripped for rotating the closure relative to the container body.

US Pat. No. 10,112,198

COLLECTOR ARCHITECTURE LAYOUT DESIGN

Academia Sinica, Taipei ...

1. A microfluidic channel comprising:a plurality of microstructures within the channel; wherein the plurality of microstructures is arranged in a plurality of columns substantially parallel to one another, wherein the plurality of columns comprise at least four columns comprising a first column adjacent to a second column, the second column adjacent to a third column, and the third column adjacent to a fourth column; wherein the number of microstructures in the first column is greater than the number of microstructures in the second column or the third column; and wherein the number of microstructures in the fourth column is greater than the number of microstructures in the second column or the third column; and
a plurality of vortex regions at which one or more vortexes are generated in response to fluid flow, wherein each vortex region of the plurality is substantially free of the plurality of microstructures and comprises at least a cylindrical volume having (1) a height of the channel and (2) a base having a diameter at least 20% a width of the channel, wherein the plurality of vortex regions of the plurality are separated from each other by at least one microstructure along a length of the channel; and
wherein said vortex regions are configured to increase the mixing of particles of interest and thereby to increase the likelihood of binding particles of interest to a microstructure.

US Pat. No. 10,112,197

DEVICES AND METHODS FOR MOLECULAR DIAGNOSTIC TESTING

Click Diagnostics, Inc., ...

1. A method of detecting a target nucleic acid using a stand-alone molecular diagnostic test device without any external instrument, the stand-alone molecular diagnostic test device including an amplification module, a detection module, and a control module, each of the amplification module, the detection module, and the control module integrated within a housing, the method comprising:heating a first heating portion of a heater of the amplification module to produce a first temperature zone within a first portion of a reaction volume of the amplification module and a second heating portion of the heater to produce a second temperature zone within a second portion of the reaction volume;
producing a flow of an input sample within the reaction volume such that the input sample is thermally cycled through at least 30 thermal cycles to amplify the target nucleic acid within the input sample to produce an output solution containing a target amplicon;
controlling, via the control module, the flow of the input sample through the reaction volume to produce a flow rate of the input sample of at least 0.2 ?l/sec;
conveying to the detection module the output solution, the detection module containing a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution, the detection module including a detection surface capturing the target amplicon to produce the signal; and
discarding the stand-alone molecular test device after the signal is read.

US Pat. No. 10,112,196

DEVICES AND METHODS FOR MOLECULAR DIAGNOSTIC TESTING

Click Diagnostics, Inc., ...

1. A method of detecting a target nucleic acid using a stand-alone molecular diagnostic test device without any external instrument, comprising:conveying an input sample from a sample preparation module to an amplification module, the sample preparation module and the amplification module each fixedly coupled within a housing of the stand-alone molecular diagnostic test device, the housing having an overall size of less than about 260 cubic centimeters, the amplification module defining a reaction volume and including a heater;
heating the input sample within at least a portion of the reaction volume via the heater to amplify the target nucleic acid molecule within the input sample thereby producing an output solution containing a target amplicon; and
reacting within a detection module within the housing each of A) the output solution and B) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution, the detection module including a detection surface configured to capture the target amplicon to produce the signal,
the stand-alone molecular diagnostic test device producing the signal in less than about 25 minutes after the input sample is conveyed from the sample preparation module.

US Pat. No. 10,112,167

METHODS, DEVICES AND SYSTEMS FOR PROCESSING OF CARBONACEOUS COMPOSITIONS

NANOTECH ENERGY, INC., L...

1. A reaction filter comprising:a) a rotatable drum assembly comprising a drum micron filter for retaining graphene or reduced graphene oxide while allowing filtrate to pass through; and
b) a spray bar assembly comprising one or more openings for dispensing at least one of a carbonaceous composition and a wash liquid inside the drum assembly, wherein the carbonaceous composition comprises graphene or reduced graphene oxide.

US Pat. No. 10,112,162

METHODS OF MIXING IMPELLER SENSING

Sartorius Stedim Biotech ...

1. A method of monitoring a flow behaviour of mixed components, comprising:rotating a mixing impeller at a first speed N1 in a mixing vessel accommodating the components to be mixed;
determining a first quantity
at the first speed N1, wherein N1 is the speed at which the mixing impeller rotates and P1 is the power required to rotate the mixing impeller at the first speed N1;decreasing the speed of the mixing impeller to a speed N2;
determining a second quantity
at the second speed N2, wherein N2 is the speed at which the mixing impeller rotates and P2 is the power required to rotate the mixing impeller at the second speed N2;comparing the first quantity
and the second quantityand detecting whether the difference between the first and second quantities is within a specified range to determine whether the flow of the components in the mixing vessel is a turbulent flow;determining the density ? of the mixed components based on at least one speed Ni for which the flow is determined to be turbulent by the following formula:

wherein ? is the density, P1 is the power required to turn the mixing impeller at the speed Ni, NP,constant is the Power number for a used mixing system configuration, Ni is the speed at which the mixing impeller rotates and D is the diameter of the mixing impeller;
further decreasing the speed of the mixing impeller;
determining the Power number NP,variable for at least one detected speed Nj at which the flow is determined to be non-turbulent by the following formula:

wherein Pj is the power required to rotate the mixing impeller at the speed Nj, ? is the density previously determined based on NP,constant, Nj is the speed at which the mixing impeller rotates, and D is the diameter of the mixing impeller; and
determining the dynamic viscosity ? of the mixed components by the following formula:

wherein ? is the calculated density, Nj is the speed at which the mixing impeller rotates, D is the diameter of the mixing impeller, Pj is the power required to rotate the mixing impeller at the speed Nj and xT corresponds to a specified relationship between the Reynolds number for the used mixing system configuration and the determined Power number NP,variable.

US Pat. No. 10,112,139

AIR FILTER MONITORING TAB

THE BOEING COMPANY, Chic...

1. An apparatus, comprising:a filter defining an enclosed open ended channel;
a housing positioned in the enclosed open ended channel;
a rod positioned at least partially within the housing; and
a membrane coupled to and extending between the housing and the rod, wherein the membrane is configured to move the rod from a first position to a second position when a force exerted on the membrane by a fluid exceeds a predetermined amount, and wherein the rod comprises a barb that extends radially-outward therefrom that prevents the rod from moving from the second position back to the first position.

US Pat. No. 10,112,135

FILTER ELEMENT AND ASSEMBLY WITH BYPASS REVERSE FLOW FILTER END CAP

PARKER-HANNIFIN CORPORATI...

1. A filter element that can be removably attached to a filter head comprising a filter media, and an end cap assembly at one end of the filter media and carried with the filter media whereby the end cap assembly will be removable with the filter media when the filter element is removed from the filter head; the end cap assembly including an end cap that includes an annular peripheral flange portion for engaging an end face of the filter media, and a central tubular portion forming with the filter media an interior fluid flow passage, the central tubular portion having an opening at an axial end thereof and an annular wall including at least one radial bypass flow passage for allowing fluid supplied to one side of the central tubular portion to bypass the filter element and flow to an opposite side of the central tubular portion; and a bypass flow valve axially movable within the central tubular portion between a closed position blocking flow from the radial bypass flow passage to the opening at the axial end of the central tubular portion during normal forward flow that flows from an inlet passage of the filter head to an outlet passage of the filter head and passes the filter media, and an open position permitting flow of fluid from the radial bypass flow passage to the opening at the axial end of the central tubular portion during bypass forward flow that flows from the inlet passage of the filter head to the outlet passage of the filter head and bypasses the filter media, and wherein the bypass flow valve is responsive to a prescribed pressure differential across the central tubular portion for moving the bypass flow valve from the closed position to the open position to permit flow through the bypass flow passage, the bypass flow valve has an opening bounded by an annular reverse flow valve seat that is integral with the bypass flow valve, and a reverse flow valve is carried by the end cap and movable between a closed position seated against the reverse flow valve seat for blocking the opening during reverse flow that flows from the outlet passage of the filter head to the inlet passage of the filter head and an open position spaced from the reverse flow valve seat for permitting flow of fluid through the opening during the normal forward flow and the bypass forward flow, wherein reverse flow that bypasses the filter media is enabled when the bypass flow valve is in the open position.

US Pat. No. 10,112,130

SELF-SUPPORTING FOLDED SHEET MATERIAL, FILTER ELEMENTS, AND METHODS

Donaldson Company, Inc., ...

1. A pleated media pack for use in a filter element; the media pack comprising:(a) a section of filtration media folded into pleats; at least some of the pleats having a major pleat depth;
(b) the section of filtration media being configured into a tube defining an interior volume, first and second opposite ends; and an opening at the first end; the opening having an outer diameter;
(c) a ratio of the pleat depth to the opening outer diameter being greater than 0.2; and
(d) wherein at least some of the pleats at the first end are inverted an opposite direction of the rest of the pleat, along only a portion of the pleat length from the first end toward the second end, and each of the pleats at the second end have outer pleat tips extending fully to the second end and are not inverted.

US Pat. No. 10,112,120

MODULAR TOY PLAY SETS

Mattel, Inc., El Segundo...

1. A toy play system, comprising:a first toy play set having a first base, the first base includes opposed upper and lower sides and a first side disposed between the upper and lower sides, the upper side includes at least one play feature, the lower side being a single unitary piece and a plurality of protrusions extends from the lower side; and
a base connector having at least two apertures, at least a first aperture of the at least two apertures receives a protrusion of the plurality of protrusions, and at least a second aperture of the at least two apertures receives a protrusion of a second toy play set having a second side, wherein the first side contacts the second side when the at least a first aperture receives the protrusion of the plurality of protrusions and the at least a second aperture receives the protrusion of the second toy play set.

US Pat. No. 10,112,117

STORAGE MEDIUM, INFORMATION-PROCESSING DEVICE, INFORMATION-PROCESSING SYSTEM, AND INFORMATION-PROCESSING METHOD FOR CONTROLLING MOVEMENT OF GAME CHARACTERS

NINTENDO CO., LTD., Kyot...

1. A non-transitory storage medium storing a program for enabling a player to play a game in which characters including at least a player character operated by the player are moved on a map including cells displayed on a display unit, and for causing a computer to execute a process, the process comprising:identifying, for each of the characters, a movement amount, based on which each of the characters is moved on the map, the movement amount being randomly determined;
moving each of the characters, on the map based on a movement amount determined for each of the characters; and
executing a mini-game on detecting that a first character included in the characters has reached a predetermined first cell on the map, wherein:
the step of moving each of the characters comprises moving the player character on the map based on an input operation performed by the player and a movement amount determined for the player character; and
the step of executing a mini-game comprises:
starting the mini-game, the first character joining the mini-game from the start of the mini-game; and
causing a second character included in the characters to join the mini-game subsequent to the first character with a delay, the second character having failed to reach the first cell as of the start of the mini-game.

US Pat. No. 10,112,113

PERSONALIZED DATA DRIVEN GAME TRAINING SYSTEM

SONY INTERACTIVE ENTERTAI...

1. A computer-implemented method comprising:detecting, by a computer system, an interest of a video game player in assistance with interacting with a context of a video game;
determining, by the computer system, an experience level of the video game player in playing the video game and an interaction of the video game player with the context;
selecting, by the computer system, an action for the assistance from potential actions, the action selected based on predicted outcomes of performing the potential actions given the experience level of the video game player, the potential actions and the predicted outcomes derived based on inputting data about the context, the experience level, and the interaction to an artificial intelligence (AI) model, the AI model trained based on historical interactions with the context of other video game players of different experience levels, and the action selected based on a predicted outcome for the action indicating that the AI model predicts a higher likelihood of success for the action relative to other actions from the potential actions; and
causing, by the computer system, a presentation about the action in response to detecting that the video game player needs the assistance.

US Pat. No. 10,112,108

CONTENT-RELATED INFORMATION DISPLAY SYSTEM

KABUSHIKI KAISHA SQUARE E...

1. A content-related information display system, comprising:a first apparatus including:
a first memory that stores content;
a first processor that outputs a drawing command for displaying the content on a first display, and generates progress status information which is related to a progress status of the content;
the first display that displays the content; and
a first interface that transmits the progress status information; and
a second apparatus including:
a second interface that receives the progress status information transmitted by the first interface of the first apparatus;
a second memory that stores content-related information which is related to the content;
a second processor that specifies the content-related information to be displayed on a second display, the content-related information being specified according to the progress status information received by the second interface and generated by the first processor; and
the second display that displays the content-related information,
wherein more detailed information is displayed on the second display than on the first display,
the content-related information is preset in the second memory,
the first display is not configured to display the content-related information, and
the first processor generates the progress status information and the second processor specifies the content-related information in response to at least one of a predetermined condition being satisfied in relation to the progress status of the content or a specific operation being received by the first processor in relation to the progress status of the content.

US Pat. No. 10,112,102

SYSTEM FOR ENERGY ON-SITE COLLECTION AND MEASUREMENT FEEDBACK

Xiao Hu, Shenzhen, Guang...

1. A system for energy collection and measurement, comprising:a plurality of fitness apparatuses, each apparatus producing mechanical energy,
a plurality of generators, each connected to a respective fitness apparatus such that operation of the respective fitness apparatus induces the respective generator to produce electrical energy corresponding to the produced mechanical energy,
a plurality of changeable energy storage accumulators connected with respective generators so as to selectively store electrical energy produced and include alarm systems providing a full-power alarm when a changeable energy storage accumulator is fully charged to indicate readiness for replacement,
a plurality of power meters with display screens, each power meter connected between a respective generator and accumulator, to respectively measure and display an equivalent currency amount of the electrical energy produced,
a plurality of two-step bank card readers, each connected with a respective power meter so as to first register an individual user and then, after an initial interval of at least five minutes, read and update data of a bank card associated with the individual user of a respective fitness apparatus and with the respective generator so as to sum a new equivalent currency amount to an existing currency balance of the individual user proportionate to an amount of electrical power produced by the respective generator during the individual's operation of the fitness apparatus at following intervals of one minute,
chargeable light-emitting devices connected with the energy storage accumulators and switches controlling the operating state of each light emitting device,
a data processing host in communication with all of the bank card readers, light-emitting devices, and power meters at an exercise site such that data of all of the power meters is transmitted to the data processing host and summarized and the data processing host can change passwords and inquire about power storage capacity of a given user and a corresponding currency amount thereof and wherein the electrical power produced is directed to charge the chargeable light-emitting devices until the light-emitting devices are fully charged and is then directed to charge the accumulators, and
a keyboard connected with the data processing host.

US Pat. No. 10,112,085

GOLF CLUB HEAD WITH REPOSITIONABLE WEIGHT

Taylor Made Golf Company,...

1. A golf club head, comprising:a body having a sole, a crown, a face at a forward end of the body, and a ribbon extending between the crown and the sole;
a channel being formed in or attached to the ribbon of the body, the channel having a length, the channel having two spaced apart channel walls and a bottom formed by an outer surface of the body;
at least one weight and weight retainer, the weight and weight retainer being continuously repositionable such that the weight can be positioned at any selected position along the channel, wherein the weight and weight retainer are retained and moveable within the channel, and wherein a fastening member threadably engages at least one of the weight and the weight retainer,
wherein at least one of the weight and the weight retainer is shaped such that at least one dimension of at least one of the weight and the weight retainer is larger than a width of the channel;
wherein the weight is a first weight, further comprising a second weight movable independently of the first weight;
wherein the weight is dimensioned to be received in and slidably movable within the channel.

US Pat. No. 10,112,082

BALL WITH INCREASED FLEXURE

1. An object for sports play comprising:a plurality of exterior panels, stitched together at their edges, configured to form a closed volume and forming, by said stitching, raised interior ridges at the edges of said exterior panels so that each exterior panel has associated therewith a recessed area essentially coextensive with said exterior panel and defined by said raised interior ridges;
an inflatable bladder occupying said closed volume;
a plurality of flat adjacently disposed interior cushioning panels, said interior panels individually having a layered structure including a first layer which occupies said recessed area and a second layer having a portion which is wider than said first layer, the wider portion of said second layer being disposed between said bladder and said raised interior ridges and separate from said raised interior ridges, said adjacently disposed interior cushioning panels having the same shape as said corresponding recessed area, said second layers of said interior panels abutting one another at their edges directly beneath said stitching.

US Pat. No. 10,112,077

ELECTRIC TRAINING APPARATUS AND EXERCISE CONTROL METHOD THEREFOR

MITSUBISHI ELECTRIC ENGIN...

1. An electric training apparatus, comprising:a rotating body configured to apply a load on an exercising person;
a load motor configured to apply a load on the rotating body via a transmission mechanism;
an exercise physiological response detection unit configured to detect an exercise physiological response value of the exercising person;
a number-of-revolutions detection unit configured to detect a number of revolutions of the rotating body;
a control unit comprising an exercise control unit, the exercise control unit being configured to perform control for gradually increasing, based on a detection result from the exercise physiological response detection unit and a detection result from the number-of-revolutions detection unit, the load of the load motor toward a set load upper limit value so that the detection result of the exercise physiological response value of the exercising person approaches a target exercise physiological response value set in advance;
a display unit configured to display the detection result from the exercise physiological response detection unit, the detection result from the number-of-revolutions detection unit, and a state of the control of the control unit; and
an input unit configured to input a control command to the control unit,
the exercise control unit being configured to change the set load upper limit value in response to the control command input from the input unit before an exercise and during the exercise by the exercising person.

US Pat. No. 10,112,072

DYNAMIC STRETCHING, STRENGTHENING AND STABILIZATION DEVICE FOR POSTURAL CORRECTION AND RETRAINING

POSTURE PERFECTOR LLC, A...

1. A dynamic stretching, strengthening and stabilization device comprising:a central member having a width and a height, with the height being greater than the width;
a resistance tube first loop on a first side of the central member and a resistance tube second loop on a second side of the central member;
a flexible handle disposed on each loop;wherein the user:can grip the handles and pull in opposing directions to actively engage the resistance tubes in a stretching/strengthening mode; and
can position each of the loops over one of the user's arms so that the central member is positioned in a region of the user's back with the height extending in a vertical direction along the user's back and with the width extending in a horizontal direction from side to side across the user's back, and the handles are positioned to cushion where the loop engages the user's pectoral or underarm region in a stabilization mode; the loops being sized to fit snugly on the user and provide passive resistance against forward shoulder curvature in the stabilization mode.

US Pat. No. 10,112,071

REAR HANDLEBAR ASSEMBLY FOR A STATIONARY BIKE

1. A rear handlebar assembly in combination with a seat and a supporting member of a stationary bike, comprising:a seat of a stationary bike for supporting a rider thereon;
a supporting member for supporting the seat of the stationary bike;
a joining member including a vertical bore and a horizontal bore, the vertical bore receiving therein the supporting member to connect the joining member to the seat;
a clasp for holding the joining member against the supporting member;
a crossbar forming a rear handlebar adapted to support the hands of a rider in an upright riding position; and
a rearwardly extending member connecting the joining member to the crossbar;
wherein the joining member includes a pair of serrated surfaces and the clasp includes a pair of clasping members with each clasping member having a mating surface to engage one of the serrated surfaces to hold the joining member in place.

US Pat. No. 10,112,065

METHOD FOR INSTALLING A FIRESTOP DEVICE OR INSULATION HAVING FIRESTOP PROPERTIES AS WELL AS A FIRESTOP MODULE

Hilti Aktiengesellschaft,...

1. A method for installing a firestop device or insulation on a line or pipe, comprising:placing the firestop device or the insulation completely around the line or pipe in the circumferential direction; and
wrapping a flexible adhesive tape containing heat-resistant fibers in a lengthwise direction of the tape in the circumferential direction of the line or pipe completely around the firestop device or the insulation.

US Pat. No. 10,112,064

HARNESS

ZEDEL, Crolles (FR)

1. A harness comprising a belt, a pair of thigh straps and a ventral suspension point, the ventral suspension point comprising:a connector positioned on the belt, the connector comprising
a connecting ring fitted to be rotatable with respect to the belt around an axis of rotation, the connecting ring being a closed ring defining a first area, and
a rod having a longitudinal axis that forms the axis of rotation of the connector, the rod fixing the connector to the belt, the rod comprising
a first end and a second end opposite the first end, the first end and the second end being disposed along the axis of rotation of the connector, and
a first attachment opening and a second attachment opening designed to cooperate for fixing an external device, the first attachment opening and the second attachment opening being defined in the rod outside the first area so that the axis of rotation of the connector passes through the first attachment opening and the second attachment opening.

US Pat. No. 10,112,059

SYSTEMS, DEVICES, AND METHODS FOR QUALITY ASSURANCE OF RADIATION THERAPY

VARIAN MEDICAL SYSTEMS IN...

8. A system for verifying radiation dose delivered to a subject, comprising:a portal dose imaging device configured to generate portal dose images of radiation dose delivered to a subject from predetermined radiation fields; and
a processing device operably connected to the portal dose imaging device and configured to store the portal dose images in a first data array having spatial and angular locations of the delivered beams (X, Y, ?) as dimensions, and to store corresponding predicted portal dose images in a second data array having spatial and angular locations of the predicted beams (X, Y, ?) as dimensions,
wherein the processing device compares points in the first data array with corresponding points in the second data array using a gamma portal dose distribution algorithm points in the first data array representing generated portal dose images, and points in the second data array representing predicted portal dose images, the gamma portal dose distribution algorithm including dose differences, spatial differences, and angular differences between corresponding points in the first and second data arrays as parameters, and
wherein the processing device determines errors in the delivered radiation dose based on the comparison.

US Pat. No. 10,112,058

SMART LASER HAIR GROWTH HELMET

Theradome, Inc., Pleasan...

1. A photo-bio-stimulation device in the form of a helmet that promotes therapeutic hair growth, comprising:a plurality of power-controlled near infrared (NIR) laser diode arrays mounted on a concave single flexible printed circuit inside a plastic helmet that generally direct a monochromatic and coherent therapeutic light across the scalp of a user wearing it;
wherein, a number of petal shapes are cut on two side edges of the flexible printed circuit and that are cupped and attached inside the plastic helmet;
a plurality of cooling air vents fenestrated through the plastic helmet that allow air heated during operation to pass outside for cooling;
a controller that operates the plurality of power-controlled near infrared (NIR) laser diode arrays according to predefined therapeutic profiles and sessions, and that maintains an operational status and log;
a proximity sensor that detects the presence of a user scalp and that triggers the controller to shut off battery power to the plurality of power-controlled near infrared (NIR) laser diode arrays if the user scalp is not then detected as being proximate;
at least one temperature sensor that triggers the controller to shut off battery power to the plurality of power-controlled near infrared (NIR) laser diode arrays if a predefined temperature is exceeded;
a speech synthesizer and a loudspeaker connected to the controller and that speak instructions and the operational status of the device to the user in a spoken language; and
a wireless transceiver capable of Internet communication with a centralized server, and that is connected to exchange status and operational data with the controller.

US Pat. No. 10,112,053

IMPLANTABLE MEDICAL DEVICES WITH HEADER STRUCTURES INCLUDING CONDUCTIVE PATHS THAT FACILITATE THE INTERCONNECTION OF FEEDTHROUGH CONDUCTORS TO ELECTRICAL CONNECTORS

MEDTRONIC, INC., Minneap...

1. An implantable medical device, comprising:a housing;
circuitry within the housing, the circuitry comprising a plurality of feedthrough conductors that exit the housing;
a header structure having a plurality of holes passing from a first side of the header structure to a second side of the header structure;
a plurality of conductive paths, with a conductive path of the plurality passing through a corresponding hole of the plurality of holes, the conductive path having a first end present on the first side of the header structure and a second end present on the second side of the header structure, the second end being electrically coupled to a corresponding feedthrough conductor of the plurality of feedthrough conductors;
a plurality of electrical connectors present within an interior of the header structure, wherein the header structure comprises a header body with a first cavity exposed to the first side of the header structure and a second cavity exposed to the second side of the header structure, with a first set of the electrical connectors of the plurality of electrical connectors being present within the first cavity and with a second set of the electrical connectors of the plurality of electrical connectors being present within the second cavity, and wherein the first end of each conductive path of the plurality of conductive paths is electrically coupled to a corresponding electrical connector of the plurality of electrical connectors within the header structure.

US Pat. No. 10,112,045

IMPLANTABLE MEDICAL DEVICE FIXATION

Medtronic, Inc., Minneap...

1. An assembly comprising:an implantable medical device including a conductive housing; and
a fixation element assembly fixedly attached to the implantable medical device near a distal end of the conductive housing, wherein the fixation element assembly includes a set of active fixation tines and an insulator to electrically isolate the set of active fixation tines from the conductive housing of the implantable medical device,
wherein the active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the implantable medical device to a hooked position in which the active fixation tines bend back towards the implantable medical device,
wherein the active fixation tines are configured to secure the implantable medical device to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue,
wherein the active fixation tines are in a circular arrangement about a base with proximal ends of the active fixation tines secured to the base, and
wherein the insulator includes a header body with notches to receive the active fixation tines and a header cap that combines with the header body to encompass the base such that the active fixation tines are fixedly attached to the implantable medical device at a location near the distal end of the conductive housing both when the active fixation tines are in the spring-loaded position and when the active fixation tines are in the hooked position.

US Pat. No. 10,112,039

CLOSED MALE LUER CONNECTOR

ELCAM MEDICAL AGRICULTURA...

1. A fluid flow connector comprising:a housing assembly having a first end and a second end arranged along a common longitudinal axis;
a forward resilient member disposed within said housing assembly, said forward resilient member having a forward end disposed alongside said first end, said forward end defining a selectably closable slit;
a rigid fluid flow conduit member at least partially disposed within said forward resilient member rearwardly of said forward end; and
a rearward resilient displacement biasing element associated with said rigid fluid flow conduit member and with said housing assembly;
said rigid fluid flow conduit member being positionable in a forward position, causing said slit to be closed,
said rigid fluid flow conduit member being positionable in a rearward position, causing said slit to be open, and
wherein displacement of said rigid fluid flow conduit member from said rearward position to said forward position causes a first volume, adjacent to and rearward of said forward end of said forward resilient member, to decrease by a first amount and a second volume, rearwardly of said rearward resilient displacement biasing element and in communication with said rigid fluid flow conduit member, to increase by a second amount, greater than said first amount.

US Pat. No. 10,112,038

UMBRELLA CHECK VALVE WITH REDUCED HEMOLYSIS

VERNAY LABORATORIES, INC....

1. A check valve assembly comprising:an elongated valve body having an inlet port, an outlet port, and an internal channel communicating between said inlet port and said outlet port, each disposed about and generally aligned with a central longitudinal axis of the valve body;
said inlet port including an umbrella check valve disposed at an entrance to said internal channel and configured to obstruct reverse flow from said internal channel into said inlet port;
a distance along said central longitudinal axis from the entrance to said internal channel toward the outlet port being denoted as x, and the a radial separation of an interior wall of the internal channel from the central longitudinal axis being denoted as r, with r varying with x according to:
r?=8+SQRT(20.25?(x?4.5)?2) for 08;  Equation (1)
r?=0.0068*x?3?0.2242*x?2+1.5392*x+9.6571 for 4.5 and
r(x)=r?(x)±2.0, where ± denotes a tolerance,  Equation (3)with the separation r defining an essentially continuously curved interior surface.

US Pat. No. 10,112,020

AIRFLOW ADAPTOR FOR A BREATH-ACTUATED DRY POWDER INHALER

Norton Healthcare Limited...

1. A method for de-agglomerating dry powder in a breath-actuated dry powder inhaler, comprising:directing a first breath-actuated airflow for entraining the dry powder from a dry powder inhaler into a first end of a swirl chamber extending along a longitudinal axis from the first end of the swirl chamber to a second end of the swirl chamber, the first airflow directed in a longitudinal direction;
directing a second breath-actuated airflow in a substantially transverse direction into the first end of the swirl chamber such that the first and the second breath-actuated airflows collide and substantially combine;
directing a portion of the combined airflows in a spiral path towards the second end of the swirl chamber;
directing all the combined airflows and any dry powder entrained therein through an outlet port in the second end of the swirl chamber and into a proximal end of a conduit of an airflow adaptor that is connected to the outlet port of the swirl chamber;
delivering all the combined airflows and any dry powder entrained therein through the conduit and to a user of the dry powder inhaler through a first outlet port defined at a distal end of the conduit that is located on a flange of the airflow adaptor;
directing a third breath-actuated airflow to the airflow adaptor having by-passed the swirl chamber; and
delivering the third breath-actuated airflow to the user through at least one secondary outlet port defined on the flange of the airflow adaptor having by-passed the conduit, wherein the third breath actuated airflow exits the dry powder inhaler as it passes through the at least one secondary outlet port, and combines with the first and second breath-actuated airflows only after the first and second breath-actuated airflows have left the airflow adaptor.

US Pat. No. 10,112,013

DEVICE FOR DELIVERING A MEDICAMENT

SHL GROUP AB, Nacka Stra...

1. A device for delivery of medicament, comprising:a) an elongated housing having a proximal end and a distal end;
b) a container mounted within the housing containing a liquid medicament and a stopper slidably arranged within the container;
c) a tubular member slidably arranged within the housing and having a distally projecting tongue;
d) an actuator comprising,
a resilient member;
a plunger rod having a proximal end in contact with the stopper and a distal end being operably connected to the resilient member, where the plunger rod has longitudinally stepped dose grooves corresponding to a plurality of fixed doses; and
a carrier fixedly arranged to an inner surface of the housing and configured not to move axially relative to the housing; and
e) a dose setting mechanism comprising a selector ring axially fixed relative to the housing, the ring rotatable relative to the housing to select one of the plurality of fixed doses through engagement of the selector ring with the stepped dose grooves,
wherein axial displacement in a distal direction of the tubular member causes the tongue to project through a hole in the selector ring to disengage the carrier from engagement with the plunger rod causing the plunger rod to move proximally as a result of a biasing force exerted by the resilient member.

US Pat. No. 10,112,006

NEEDLE SHIELDING ASSEMBLIES AND INFUSION DEVICES FOR USE THEREWITH

Becton, Dickinson and Com...

1. An infusion set, comprising:a base, comprising:
a base portion having a column extending proximally therefrom, the column having a plurality of inverted J-shaped engagement structures with cantilevered ends, the engagement structures forming engagement pockets therein and being circumferentially arrayed around the column and separated by a plurality of slots;
a septum disposed within the column; and
a cannula protruding distally from the base portion and being in fluid communication with a distal side of the septum; and
a locking fluid connector, comprising:
a tubing portion having a tubing port for connecting tubing thereto; and
a hub portion for connecting with the base, the hub portion comprising:
a domed portion;
a blunt cannula for penetrating the septum, the blunt cannula extending from the domed portion and being fluidly connected with the tubing port;
a plurality of engagement fingers protruding radially inward; and
a spring element held within the domed portion by the engagement fingers;
wherein:
the engagement fingers are alignable with the aligning the slots;
the locking fluid connector is displaceable toward the base when the blunt cannula is aligned with the septum and the engagement fingers are aligned with the slots, thereby compressing the spring element;
the locking fluid connector is rotatable about the column once the engagement fingers have distally cleared the cantilevered ends of the engagement structures; and
the locking fluid is displaceable away from the base under the force of the spring element with the engagement fingers disposed within the engagement pockets to lock the fluid connector to the base in one of a plurality of discrete circumferential orientations.

US Pat. No. 10,111,999

MEDICAL RESERVOIRS WITH VARIABLE-ELEVATION DROP TUBES

Terumo Cardiovascular Sys...

1. A medical fluid reservoir comprising:a reservoir shell defining an interior space configured for containing a medical fluid;
a drop tube disposed within the interior space and configured to introduce the medical fluid into the interior space, the drop tube defining a drop tube length, the drop tube having a first end that is coupled to the reservoir shell and a second end that has freedom to move within the interior space; and
a buoyant member coupled to a portion of the drop tube adjacent the second end, the drop tube length adjusting in response to movement of the buoyant member.

US Pat. No. 10,111,998

METHODS, SYSTEMS AND DEVICES FOR TREATING HYPERTENSION

Rox Medical, Inc., San C...

1. A method for treating a disease or disorder in a patient, the method comprising:advancing a vessel-to-to vessel guidewire through a starting vessel to a target vessel with a needle delivery device;
advancing a flow creation device over the advanced vessel-to-vessel guidewire to be positioned through vessel walls of the starting vessel and the target vessel; and
creating a flow path between the starting vessel and the target vessel with the flow creation device, wherein the flow creation device comprises a clip deployment catheter comprising an anastomotic clip and an outer sheath covering the anastomotic clip, and wherein creating the flow path comprises:
(i) moving a control of a handle of the clip deployment catheter from a first ready to deploy position to a first deployed position, thereby causing the outer sheath of the clip deployment catheter to retract a first distance relative to a distal tip of the clip deployment catheter while the anastomotic clip is held stationary relative to the distal tip, allowing at least one distal arm of the anastomotic clip to deploy,
(ii) moving the control from the first deployed position to a second ready to deploy position, and
(iii) moving the control from the second ready to deploy position to a second deployed position, thereby causing the outer sheath of the clip deployment catheter to retract a second distance relative to the distal tip of the clip deployment catheter while the anastomotic clip is held stationary relative to the distal tip, allowing at least one proximal arm of the anastomotic clip to deploy.

US Pat. No. 10,111,986

PRODUCTION OF IN SITU CROSSLINKABLE POLYISOBUTYLENE-POLYURETHANE NANOFIBERS AND COATINGS

Cardiac Pacemakers, Inc.,...

1. A method for making an implantable medical device including a polyisobutylene-polyurethane block copolymer, the method comprising:polymerizing a polyisobutylene diol, a diisocyanate, a chain extender, and optionally a polyether diol, in a solvent system to form a polyisobutylene-polyurethane block copolymer solution;
depositing the polyisobutylene-polyurethane block copolymer solution onto at least a portion of the implantable medical device; and
evaporating the solvent system from the deposited polyisobutylene-polyurethane block copolymer solution wherein the solvent system includes one or more solvents components present during the polymerization step and the depositing step.

US Pat. No. 10,111,985

BIOCOMPATIBLE HYDROGEL POLYMER FORMULATIONS FOR THE CONTROLLED DELIVERY OF BIOMOLECULES

MEDICUS BIOSCIENCES, LLC,...

1. An in vivo gelling pharmaceutical pre-formulation, comprising:(a) one or more multi-ARM nucleophilic PEG monomers, wherein the multi-ARM PEG nucleophilic monomers comprise a polyol core, wherein the polyol core is selected from the group consisting of

wherein the polyol core is substituted with 3-8 R-groups, wherein R is:

wherein n is 1-200;
(b) one or more multi-ARM nucleophilic PEG monomers, wherein the multi-ARM PEG nucleophilic monomers comprise a polyol core, wherein the polyol core is selected from the group consisting of

wherein the polyol core is substituted with 3-8 R-groups, wherein R is:

wherein n is 1-200;
(c) one or more multi-ARM-PEG electrophilic monomers having more than two electrophilic arms, wherein each electrophilic arm comprises a PEG chain and terminates in an electrophilic group;
(d) an aqueous buffer in the pH range of about 5.0 to about 9.5; and
(e) at least one pharmaceutically active biomolecule that is a monoclonal antibody;wherein the in vivo gelling pharmaceutical pre-formulation at least in part polymerizes and/or gels at a target site of a human body to form a biocompatible hydrogel polymer,wherein the molecular weight of the multi-ARM PEG nucleophilic monomers and/or the multi-ARM PEG electrophilic monomers is about 500 to about 40000.

US Pat. No. 10,111,975

STERILIZATION METHODS AND APPARATUS AND ADAPTIVE CONTROL THEREOF

TS03 Inc., Quebec (CA)

1. A method for sterilizing a load in a sterilization chamber under vacuum, comprising the steps of:admitting a sterilant gas into the sterilization chamber under vacuum;
during admission of the sterilant gas monitoring a sterilant condensation related parameter in the sterilization chamber;
determining a value of the sterilant condensation related parameter, either upon the occurrence of condensation, or at the onset of condensation;
selecting a sterilization cycle among a plurality of predetermined sterilization cycles according to the value of the condensation related parameter; and
performing the selected sterilization cycle for sterilizing the load, wherein the sterilant gas is admitted at a constant rate and the sterilant condensation related parameter is the chamber pressure.

US Pat. No. 10,111,973

METHOD AND SYSTEM FOR CLEANING AND SANITIZING CONVEY LINES

Schenck Process LLC, Kan...

1. A sanitization system for sanitizing a convey line including a first end and a second end, wherein the convey line is used to convey particulate material, the sanitizing system comprising:a cleaning system configured to remove residual build-up of particulate material within the convey line, wherein said cleaning system comprises a pigging system;
an air source configured to generate a stream of air and release the stream of air into the first end of the convey line; and
an ozone generation and delivery module configured to inject ozone into the air stream,
wherein the ozone generation and delivery module includes a humidifier configured to inject moisture into the air stream,
wherein a combination of ozone and moisture injected into the air stream is configured to kill and/or remove contaminants from the convey line.

US Pat. No. 10,111,971

MAGNETIC NANOPARTICLES

The General Hospital Corp...

1. A method of determining the presence of a target molecule in a subject, the method comprising:administering to the subject a nanoparticle, wherein the nanoparticle comprises:
a solid ferromagnetic core;
a super-paramagnetic shell on and contacting the surface of and surrounding the solid ferromagnetic core, wherein the super-paramagnetic shell has a thickness between about 0.5 nm and about 3 nm; and
a targeting moiety on the super-paramagnetic shell that specifically binds to the target molecule;
providing sufficient time for the nanoparticle to bind to the target molecule; and
generating a magnetic resonance image of the subject, wherein a signal in the image indicates the presence of the target molecule.