US Pat. No. 10,391,537

METHOD AND SYSTEM FOR FLANGING A METAL PIECE

Ford Motor Company, Dear...

1. A method of forming a metal part, comprising:drawing a sheet metal blank to form a drawn region and a flange region;
performing a first flanging operation to the flange region with a first die to form an intermediate shaped part having a region of increased material on the flange region; and
performing a second flanging operation to the intermediate shaped part with a second die to remove the region of increased material;
wherein the step of performing the first flanging operation includes bending the flange region at a first angle.

US Pat. No. 10,391,530

LIQUID-REPELLENT SURFACES MADE OF ANY MATERIALS

THE REGENTS OF THE UNIVER...

1. A liquid-repellent artificial surface comprising:a surface containing thereon a plurality of microstructures extending away from the surface and separated by a pitch of less than 500 ?m and having a doubly re-entrant topology situated atop respective base structures with a liquid disposed on the surface and in contact with the plurality of microstructures and a liquid-solid contact fraction (fs) of less than 50%, wherein the doubly re-entrant topology comprises a cap portion and downwardly extending lip extending from a periphery of the cap portion, the downwardly extending lip comprising a substantially uniform thickness.

US Pat. No. 10,391,529

EXHAUST SYSTEM, SEMICONDUCTOR MANUFACTURING EQUIPMENT, AND METHOD FOR OPERATING THE EXHAUST SYSTEM

TOSHIBA MEMORY CORPORATIO...

13. A semiconductor manufacturing equipment comprising:a chamber configured to perform processing of a processing body;
a gas supply mechanism configured to supply a gas to the chamber, the gas being used in the processing; and
an exhaust system configured to exhaust the chamber,
the exhaust system comprising:
a first pump unit, the first pump unit including a first exhaust chamber, a first intake port, a first exhaust port, and a first rotor, the first intake port, the first exhaust port, and the first rotor being provided in the first exhaust chamber;
a second pump unit, the second pump unit including a second exhaust chamber, a second intake port, a second exhaust port, and a second rotor, the second intake port, the second exhaust port, and the second rotor being provided in the second exhaust chamber;
a shaft, the shaft linking the first rotor and the second rotor; and
a motor, the motor being configured to cause the first rotor, the second rotor, and the shaft to rotate;wherein the chamber includes a chamber exhaust port,and the semiconductor manufacturing equipment further comprising:a first exhaust pipe connected to the chamber exhaust port;
a second exhaust pipe connected to the first exhaust pipe and the first intake port of the exhaust system;
a third exhaust pipe connected to the first exhaust pipe and the second intake port of the exhaust system;
a first valve provided in the second exhaust pipe; and
a second valve provided in the third exhaust pipe,and further comprising:a vent line connected to the gas supply mechanism,whereinthe gas supply mechanism is configured to further supply a cleaning gas, and
a supply path of the cleaning gas includes
a first path via the chamber; and
a second path via the vent line.

US Pat. No. 10,391,526

ELECTROSTATIC CHUCK CLEANING FIXTURE

Lam Research Corporation,...

1. A cleaning fixture assembly for protecting an electrostatic chuck during a wet cleaning process, the electrostatic chuck being suitable for supporting semiconductor substrates, the cleaning fixture assembly comprising:a sealing plate capable of aligning with and engaging a backside of the electrostatic chuck, the sealing plate including:
a pocket formed on a surface of the sealing plate, the pocket having a pocket depth and being capable of receiving the backside of the electrostatic chuck; and
an annular seal portion surrounding the pocket, the annular seal portion having a diameter greater than that of the backside of the electrostatic chuck such that the annular seal portion extends outwardly beyond the backside of the electrostatic chuck and is capable of surrounding the backside of the electrostatic chuck with which the sealing plate is aligning;
a first O-ring engaging the annular seal portion of the sealing plate;
a plurality of through-holes in the pocket of the sealing plate, the plurality of the through-holes being all of the through-holes formed in the pocket; and
a plurality of second O-rings each surrounding corresponding one of the plurality of through-holes in the pocket of the sealing plate such that all of the through-holes formed in the pocket of the sealing plate are surrounded by the second O-rings,
wherein:
the plurality of through-holes are arranged to align with passages formed in the backside of the electrostatic chuck, the passages including lift pin holes and helium holes in the backside of the electrostatic chuck, the through-holes being capable of providing fluid communication with the passages thereby allowing cleaning media to circulate therethrough, and
the plurality of second O-rings are positioned to allow the cleaning media to engage the passages in the electrostatic chuck while sealing the cleaning media from reaching the backside of the electrostatic chuck during the wet cleaning process.

US Pat. No. 10,391,522

CLEANING DEVICE FOR A PROCESSING PLATEN PRESS

BOBST MEX SA, (CH)

1. A device for cleaning a platen of a processing platen press, whereinthe processing platen press comprises a lower platen and an upper platen, at least one of the platens is movable toward or away from the other of the platens and at least one of the platens is arranged to allow tools to process a plate element fed between the lower and the upper platen;
the device comprising:
a frame having a base defining a base plane substantially parallel to a surface on which the frame is positioned; the frame comprises moving elements configured for moving the frame relative to the surface on which the frame is positioned;
a lift member arranged at the frame and the lift member is configured such that a relative movement can be executed between the frame and the lift member in a direction substantially perpendicular to the base plane;
a pneumatic lifting device configured for moving the frame relative to the lift member; and
a rotating element arranged on the lift member and configured to rotate around an axis substantially parallel to the direction of relative movement between the frame and the lift member.

US Pat. No. 10,391,520

PRESSURE WAVE GENERATOR WITH A SABOT LAUNCHED PISTON

General Fusion Inc., Bur...

1. A pressure wave generator for generating a pressure wave, the pressure wave generator comprising:a piston having a body with a first surface and a second surface;
a housing having an inner bore, a first end, and a second end;
a sabot configured to carry the piston within the inner bore from the first end towards the second end along a longitudinal axis of the inner bore;
an impact surface at the second end of the housing in communication with the inner bore, the impact surface capable of being coupled to a medium;
a driver configured to apply a force to the sabot to accelerate the sabot towards the second end of the inner bore; and
a brake configured to apply a restraining force to the sabot to slow down the sabot so that the piston becomes at least partially separated from the sabot.

US Pat. No. 10,391,518

METHOD FOR MANUFACTURING TRANSPARENT PATTERN PRINT STEEL PLATE

POSCO, Pohang-si, Gyeong...

1. A method of manufacturing a transparent pattern printed steel plate, comprising:forming a printed paint film layer by jetting transparent ink onto at least one surface of a steel plate at a rate of 1 kHz to 20 kHz;
curing the printed paint film layer with ultraviolet light to form a cured printed paint film layer; and
after the forming of the printed paint film layer, drying the printed paint film layer at room temperature for a period of time exceeding 0 seconds to 2 seconds or less.

US Pat. No. 10,391,517

DISPENSER ASSEMBLY

SULZER MIXPAC AG, Haag (...

1. A dispenser assembly, comprising:a rod having a plunger receiving end with a clip receiving portion;
a plunger having a rod receiving structure with a rod engaging clip biased to fit to the clip receiving portion of the rod for movement therewith; and
a stopper having a plunger receiving space that defines an aperture extending through the plunger receiving space with the rod extending through the aperture, the plunger receiving space being dimensioned such that with the rod receiving structure of the plunger located within the plunger receiving space, movement of the rod engaging clip is restricted by contact with surfaces of the plunger receiving space preventing release of the rod from the plunger, and, the stopper being further configured such that with the rod receiving structure being spaced apart from the plunger receiving space, movement of the rod engaging clip is unrestricted.

US Pat. No. 10,391,514

COATING APPLICATION WITH AUTOMATED BRUSHING

1. A device to apply a coating to a workpiece, the device comprising:a robot arm having one or more joints, the joints configured to allow rotational and/or translational movement, the robot arm comprising:
an application end having a base;
a nozzle operatively connected to the base, the nozzle configured to dispense the coating onto the workpiece;
an actuator operatively connected to the base; and
a brush connected to the actuator, the brush configured to brush a portion of the coating dispensed onto the workpiece, wherein the actuator is configured to rotate the brush relative to the base, and wherein the actuator is configured to move the brush between a retracted position and a deployed position in a direction that is substantially linear and substantially parallel to a longitudinal axis of the nozzle, the brush being positioned farther away from the nozzle in the deployed position than in the retracted position.

US Pat. No. 10,391,512

MULTIFUNCTIONAL IRRIGATION PLIERS AND METHOD OF PIERCING, CUTTING AND FITTING AN IRRIGATION TUBE

1. An irrigation pliers, the pliers comprising:a first jaw and a second jaw being pivotally attached together at a pivoting joint to allow the jaws to be pivotally displaced toward and away from each other by moving a first handle and a second handle to and away from each other, the first jaw defined by a first gripping surface, the second jaw defined by a second gripping surface, whereby the gripping surfaces are generally opposed and complementary to each other;
a proximal concavity configured to fixedly retain a blade, the proximal concavity disposed on the first jaw;
a saddle disposed on the second jaw, and generally across from the blade, whereby closure of the jaws causes the blade to move towards the saddle;
a first middle concavity configured to fixedly retain a spike, the first middle concavity disposed on the first jaw;
a second middle concavity disposed on the second jaw, and generally across from the spike, whereby closure of the jaws causes the spike to move towards the second middle concavity;
a first terminal region disposed at the terminus of the first jaw, the first terminal region comprising a first distal concavity, the first distal concavity defined by a first slot having a first textured surface; and
a second terminal region disposed at the terminus of the second jaw, the second terminal region comprising a second distal concavity, the second distal concavity defined by a second slot having a second textured surface.

US Pat. No. 10,391,510

METHOD FOR NOZZLE FLOW DETECTION

CNH Industrial America LL...

1. A method for nozzle flow detection comprising:receiving a first fluid at a first inlet of a nozzle body and a second fluid at a second inlet of the nozzle body, the nozzle body including an outlet; and
interconnecting a mixing body to the nozzle body, the mixing body defining a mixing chamber in communication with the first and second inlets of the nozzle body with the mixing body connected to the nozzle body;
receiving the first and second fluids in the mixing chamber and mixing the first and second fluids in the mixing chamber to provide a mixed fluid;
operatively connecting a control valve to the mixing body;
adjusting the control valve to control a volume of the mixed fluid to be discharged from the outlet of the nozzle body
discharging the mixed fluid at the outlet of nozzle body;
using a microphone positioned proximal to the outlet to communicate acoustic data corresponding to the discharge of the mixed fluid at the outlet;
holding a calibration measurement in a data structure, the calibration measurement corresponding to a discharge of fluid at the outlet, the calibration measurement being derived from acoustic data provided by the microphone; and
receiving a flow measurement corresponding to a discharge of mixed fluid at the outlet, the flow measurement being derived from acoustic data provided by the microphone;
comparing the flow measurement to the calibration measurement to determine an error; and
implement closed loop Proportional-Integral-Derivative controller (PID) control to minimize the error.

US Pat. No. 10,391,509

PUMP DISPENSER AND SYSTEM COMPRISING A REFILL CARTRIDGE AND THE PUMP DISPENSER

Colgate-Palmolive Company...

1. A system, comprising:a pump dispenser comprising:
a body defining a hollow interior and an opening through which at least a portion of a refill cartridge containing a flowable substance is receivable into the hollow interior;
a lid for closing the opening of the body; and
a pump for pumping the flowable substance from the refill cartridge when the portion of the refill cartridge is in the hollow interior and the lid closes the opening of the body;
wherein the lid comprises a dip tube with a lumen fluidly connected to the pump, the dip tube having a tapered end that is located in the hollow interior of the body when the lid closes the opening of the body; and
the refill cartridge, wherein the refill cartridge comprises a container defining a chamber containing the flowable substance and having a rim defining an opening through which the flowable substance is dispensable from the chamber, and a seal attached to the container and closing the opening, wherein the seal is attached to the rim;
wherein the seal consists of one of a film, a membrane, and a foil, and wherein
the seal is puncturable by the tapered end of the dip tube when the portion of the refill cartridge is in the hollow interior and the lid is moved relative to the body to close the opening of the body.

US Pat. No. 10,391,506

SPRAY APPLICATION SYSTEM COMPONENTS COMPRISING A REPELLENT SURFACE AND METHODS

3M Innovative Properties ...

1. A component of a spray application system, wherein the component is a liquid reservoir or a liquid reservoir liner comprising a liquid repellent surface such that the receding contact angle with water ranges from 90 degrees to 135 degrees and the liquid repellent surface repels water-based paint having a water soluble volatile organic solvent of at least 10 g/liter.

US Pat. No. 10,391,505

SPRAY NOZZLE APPARATUS FOR SPRAY-DRYING APPLICATIONS

Societe des Produits Nest...

1. A single phase spray nozzle apparatus for a spraying apparatus, the nozzle apparatus comprising:a nozzle provided with at least one nozzle orifice for outputting spray droplets of a product to be dried and at least one inlet orifice for transferring the product into a nozzle chamber, the nozzle chamber comprising walls defining a volume of the nozzle chamber, the nozzle chamber further comprising an apparatus for adjusting a size of the outputted spray droplets inline during a spray drying process, the apparatus comprises a plunger for adjusting the volume of the nozzle chamber based on spray drying process parameters and product parameters obtained inline during the spray drying process, the walls of the nozzle chamber do not have a turbulence generating surface, and the product to be dried has a viscosity between 1 and 1000 mPa·s;
an electric drive for adjusting geometry of the nozzle chamber, the electric drive controlled by a control device based on the spray drying process parameters and the product parameters obtained inline; and
a connecting sleeve releasably fixed to the electrical drive and providing a longitudinal bore for rotatably accommodating a hollow shaft which transfers a rotating motion of an output shaft of the electrical drive to an adjusting pin driving the plunger into and out of the nozzle chamber, wherein the nozzle chamber is provided by a swirl chamber body inserted into an inner chamber of a nozzle body, the nozzle body releasably fixed to the connecting sleeve, the swirl chamber body is provided with an opening channel arranged in correspondence to the at least one inlet orifice for introducing the product into a swirl chamber of the swirl chamber body, the swirl chamber is provided with a helicoidal spiral-type tightening guiding face for accelerating the product into the direction of the at least one nozzle orifice.

US Pat. No. 10,391,504

WATER STOP SWITCH DEVICE AND SHOWER HEAD

XIAMEN SOLEX HIGH-TECH IN...

1. A water stop switch device, comprising: a main body, a retractable slide shaft driving mechanism and a sealing element; wherein: the main body includes a water passage; the sealing element is disposed in the water passage; one end of the sealing element is coupled to the retractable slide shaft driving mechanism; the sealing element moves in the water passage to open the water passage; another end of the sealing element and the main body form a chamber; a side wall of the sealing element includes a through hole connecting the water passage and the chamber; an external periphery of the sealing element includes a first sealing ring and a second sealing ring; the through hole is downstream of the first sealing ring and the second sealing ring in a water flow direction; and when the water passage is open, the chamber is full of water to reduce the pressure difference at the one end and the other end of the sealing element; the second sealing ring is coaxial with the first sealing ring and equal in size to the first sealing ring; and the second sealing ring always contacts an internal wall of a protruding ring of a spindle in a sealing way, to close a clearance between the sealing element and the protruding ring, so that the chamber is connected to the water passage only by the through hole, the main body further includes the spindle and a valve body; the spindle is connected to one end of the valve body in an axial direction of the valve body; and a connection of an inlet to the water passage is formed between the spindle and the valve body; and when the sealing element moves in a direction closing the water passage, the first sealing ring abuts against an internal wall of the valve body to break the connection of the water passage and the inlet.

US Pat. No. 10,391,501

MOVABLE ATTACHMENT FOR ROLLER PRESSES AND A METHOD FOR REMOVING CERTAIN PARTS THEREOF

1. A roller press (1) comprising:a movable bearing housing (10);
a grinding roller (13);
a frame assembly comprising one or more of a plurality of top members (2) selectively separable from one or more of a plurality of side members (3) selectively separable from one or more of a plurality of bottom members (4); the one or more of a plurality of side members (3) extending in a z-axis (z) direction; the one or more of a plurality of top members (2) and the one or more of a plurality of bottom members (4) extending in a y-axis (y) direction which is perpendicular to the z-axis (z) direction; and
a force generation device (5) configured to apply force to the movable bearing housing (10) and being movably attached at one end of its two ends to the one or more of a plurality of said side members (3) by a mounting plate (6) and a connection device (7), and the other end of the two ends is a free end for sliding in relative to the movable bearing housing in an x-axis (x) direction;
wherein said force generation device (5) is configured to rotate or slide with respect to the frame assembly in the x-axis (x) direction which is perpendicular to both the z-axis (z) and the y-axis (y) directions so that said force generation device (5) is removable from the frame assembly when said plurality of top members (3) are connected to said side members (3) and fixed in a closed horizontal position;
wherein said connection device (7) comprises a hinge (8) that is rotatable about the y-axis (y) or rotatable about the z-axis (z), or wherein said connection device (7) comprises a sliding device that is slidable in an x-z plane (12) defined by the x-axis (x) and z-axis (z) directions.

US Pat. No. 10,391,498

SYSTEMS AND METHODS FOR NUCLEIC ACID AMPLIFICATION

Spartan Bioscience Inc., ...

1. A system for substantially irreversibly sealing a nucleic acid amplification reaction vessel, comprising:a base, comprising:
a top surface of the base and a bottom surface of the base, and
an opening in the top surface of the base defining a passage that extends from the opening in the top surface of the base to an opening in the bottom surface of the base;
a nucleic acid amplification reaction vessel which is seated within the passage and protrudes through the opening in the bottom surface of the base, comprising:
a receptacle portion distal to the bottom surface of the base for holding a nucleic acid amplification reaction mixture,
walls of the nucleic acid amplification reaction vessel, comprising an inner surface,
wherein the walls of the nucleic acid amplification reaction vessel extend from the receptacle portion of the nucleic acid amplification reaction vessel towards the bottom surface of the base,
a collection cap, comprising:
a sample collecting tip,
a top portion of the collection cap proximal to the sample collecting tip of the collection cap, and
an outer surface of the collection cap between the sample collecting tip of the collection cap and the top portion of the collection cap,
wherein when the collection cap is inserted through the passage and into the nucleic acid amplification reaction vessel, the outer surface of the collection cap contacts the inner surface of the walls of the nucleic acid amplification reaction vessel thereby creating a seal, wherein a hook, handle, or protrusion for grasping cannot be used to remove the collection cap from the nucleic acid amplification reaction vessel, thereby rendering the seal irreversible, and
wherein when sealed, the top portion of the collection cap is recessed beneath the opening in the top surface of the base so that the collection cap is inaccessible; and
a lid comprising at least one dimple or protrusion,
wherein the lid is moveable from a first position to a second position, so that when the lid is in the second position, (a) the lid covers the top surface of the base, (b) the at least one dimple or protrusion aligns with and extends into the opening in the top surface of the base, and (c) the lid is irreversibly locked to the base.

US Pat. No. 10,391,497

DEVICES, METHODS AND SYSTEMS FOR REDUCING SAMPLE VOLUME

Theranos IP Company, LLC,...

1. A system for analyzing a small-volume fluid sample, comprising:an automated sample analysis device, said device being configured for use with a sample container, said sample container having a cavity, said cavity having a first volume, the sample container being configured to hold a fluid sample within said cavity;
a plurality of inserts coupled together in a predetermined configuration, each of said inserts for placement within the cavity of the sample container, each of said inserts having a first outer portion have a first diameter greater than a diameter of the cavity and a second outer portion have a second outer diameter, and an insert cavity configured to hold a fluid sample of no more than about 150 ?L, wherein the second outer diameter is sized so that the second outer portion is in slidable contact with the cavity of the sample container said insert cavity having a second volume, said second volume being smaller than said first volume;
wherein the insert cavity is selected from the group consisting of:
i) an insert cavity having a wall, said wall comprising an angle effective to provide a taper of said wall of said insert cavity, wherein the taper becomes narrower towards the lower portion
wherein the insert cavity further comprises a bevel, a floor, and a floor angle formed by said floor and said bevel, wherein the floor angle comprises an angle of between about 100° to about 140°.

US Pat. No. 10,391,496

DEVICES, SYSTEMS, METHODS, AND KITS FOR RECEIVING A SWAB

Theranos IP Company, LLC,...

19. A swab container, said swab container being configured for receiving a swab, comprising:at least one entry port, said entry port configured to receive at least one swab having a handle;
an assay chamber having a first port and a second port, said assay chamber being configured to receive at least a portion of a swab, wherein the first port is located in a plane above the second port;
a conduit comprising an interior channel connecting said entry port with said assay chamber, said conduit being configured to accept at least a majority of said swab handle therein, wherein said conduit is coupled to the assay chamber in non-vertical orientation, wherein the conduit is coupled at an acute angle relative to a longitudinal axis of the assay chamber and the entry port is located in a plane above the second port;
wherein said conduit provides fluidic communication between said entry port and said assay chamber effective that passing a swab through said entry port into said conduit allows at least a portion of the swab to be placed within said assay chamber through the second port, and wherein said interior channel of said conduit is configured to squeeze a portion of a swab placed in or through said conduit interior channel portion adjacent to said assay chamber; wherein longitudinal length of the conduit is greater than longitudinal length of the assay chamber.

US Pat. No. 10,391,484

SAMPLE DELIVERY SYSTEM

Siemens Healthcare Diagno...

1. A device, the device comprising:a breakable capillary tube, the breakable capillary tube absorbing and retaining a sample of a first liquid by capillary action when placed in contact with the first liquid, the breakable capillary tube have a generally hollow tubular body that is open on one or both ends;
a force assisted sample ejection mechanism, the force assisted sample ejection mechanism releasing at least part of the sample of the first liquid from the breakable capillary tube when the sample of the first liquid is retained in the breakable capillary tube, the force assisted sample ejection mechanism breaking the breakable capillary tube into at least two pieces in order to release the first liquid.

US Pat. No. 10,391,481

REGENERATION OF ACIDIC IONIC LIQUID CATALYSTS

Chevron U.S.A. Inc., San...

1. A process for regenerating an acidic ionic liquid catalyst which has been used to catalyze a reaction in a reaction zone and which has been deactivated during the reaction by a formation of complexes of conjunct polymers with an anion of the acidic ionic liquid catalyst, comprising removing the acidic ionic liquid catalyst from the reaction zone and breaking up the complexes of the conjunct polymers in the acidic ionic liquid catalyst in a separate regeneration zone to increase a catalytic activity of the acidic ionic liquid catalyst for the reaction; wherein the acidic ionic liquid catalyst is a fused salt ionic liquid composed of organic-based cations and inorganic anions.

US Pat. No. 10,391,464

CENTRIFUGAL BLOWER SYSTEM WITH INTERNAL GAS MIXING AND GAS PHASE CHEMICAL REACTOR INCORPORATING SAME

WATT FUEL CELL CORP., Mo...

1. A centrifugal blower system comprising:a) a series of blower units including at least a first blower unit and a second blower unit, the first blower unit in the series comprising a first casing having a first axial inlet, a first radial outlet, a first impeller disposed within the first casing for drawing a first gaseous medium at a first pressure into the first axial inlet and expelling the first gaseous medium at a second higher pressure through the first radial outlet into a duct having a gas flow passageway defined by a gas flow-confining wall and a motor for driving the first impeller;
b) the second blower unit comprising a second casing having a second axial inlet in communication with an outlet of the duct, a second radial outlet, and a second impeller disposed within the second casing for drawing the first gaseous medium into the second axial inlet and expelling a second gaseous medium through the second radial outlet:
c) a gas flow inlet in communication with the duct, for admitting the second gaseous medium to the gas flow passageway of the duct, the gas flow inlet being defined in or connected to the gas flow-confining wall of the duct, whereby the second gaseous medium, mixes with the first gaseous medium in second blower unit to form a gas mixture.

US Pat. No. 10,391,461

BABY BOTTLE WITH MIXER

1. A baby bottle with a mixer, comprising:a bottle having an open upper end and a closed lower end;
a cap having a central aperture formed therein, the cap being adapted for releasably covering and sealing the open upper end of the bottle;
a feeding nipple disposed over the central aperture formed through the cap for selectively dispensing liquid contained in the bottle to a baby;
a filter housing secured to an inner surface of the cap and extending toward the closed lower end;
a filter removably received within the filter housing;
an internal wall mounted within the bottle such that a fluid-tight chamber is defined between the internal wall and the closed lower end of the bottle and a liquid reservoir for containing milk and other liquids for administration to the baby is defined between the internal wall and the open upper end;
an agitator rotatably mounted on an upper surface of the internal wall and extending into the liquid reservoir a distance to be adjacent the filter housing for mixing formula in the liquid reservoir;
a motor mounted within the fluid-tight chamber, the motor being mechanically coupled with the agitator for selectively driving rotation thereof; and
a controller in communication with the motor, the controller selectively generating motor actuation signals to selectively actuate the motor.

US Pat. No. 10,391,451

OSMOSIS APPARATUS

I.D.E. TECHNOLOGIES LTD.,...

1. An osmosis element comprising a central permeate tube and a membrane element,the membrane element having a first part and a second part, the first part having a top edge for location adjacent the central permeate tube, the second part being disposed at the opposite edge, the first part comprising a material to allow water to flow therethrough, the second part comprising at least two nearby permeate spacers extending from the first part to allow water to flow therethrough, the at least two nearby permeate spacers having a semi-permeable membrane attached to opposed faces of the at least two nearby permeate spacers,
the central permeate tube comprising an external wall comprising a first end section and a second end section, the central permeate tube further comprising a longitudinally extending internal separator defining at least one first channel and at least one second channel each extending longitudinally from the first end section to the second end section within the central permeate tube, wherein the at least one first channel and the at least one second channel are open to flow at both the first end section and the second end section, at least one first aperture extending from the at least one first channel though the external wall and at least one second aperture extending from the at least one second channel through the external wall, the at least one first and second apertures being longitudinally offset.

US Pat. No. 10,391,444

SYSTEMS AND METHODS TO DEBOTTLENECK AN INTEGRATED OIL AND GAS PROCESSING PLANT WITH SOUR GAS INJECTION

CHEVRON U.S.A. INC., San...

1. A system for increasing oil and/or gas production in an integrated oil and gas production plant including hydrogen sulfide removal and sour-gas injection, comprising:a. a separator for separating produced fluid from a subterranean reservoir into an associated gas stream containing 1-50% hydrogen sulfide by volume, a water stream and an oil stream;
b. an associated gas compressor for compressing a first portion of the associated gas stream to form a first compressed associated gas stream;
c. a hydrogen sulfide-selective membrane to remove hydrogen sulfide from the first portion of the associated gas stream and form a permeate stream enriched in hydrogen sulfide and a retentate stream depleted in hydrogen sulfide and enriched in hydrocarbon gases; wherein the hydrogen sulfide-selective membrane is upstream or downstream of the associated gas compressor;
d. a first gas processing plant for receiving a feed gas stream comprising the retentate stream and a portion of the oil stream from the separator, wherein the first gas processing plant includes an amine unit for removing hydrogen sulfide from the feed gas stream and producing a hydrogen sulfide-enriched stream and a hydrocarbon-enriched stream; and a Claus unit for producing elemental sulfur from the hydrogen sulfide-enriched stream;
e. a second gas processing plant for receiving and compressing a second portion of the associated gas stream and a portion of the oil stream from the separator to form a second compressed associated gas stream, wherein the second gas processing plant includes one or more gas compressors;
f. a permeate compressor or an eductor for increasing a permeate stream pressure of the permeate stream to form a compressed permeate stream; and
g. a sour gas compressor for receiving and compressing the second compressed associated gas stream and the compressed permeate stream to form a sour gas injection stream for injecting into a subterranean formation;
wherein the hydrogen sulfide-selective membrane is upstream of the associated gas compressor.

US Pat. No. 10,391,435

STERILIZING METHOD AND APPARATUS

Turbett Surgical LLC, Ro...

12. A method of drying contents in a sterilization container, the method comprising:(a) placing contents in a sterilization container having a top wall, a bottom wall, a rear wall, a right sidewall, a left sidewall, and a door defining an interior volume sized to receive a plurality of instrument trays, each instrument tray sized to retain a plurality of medical instruments, wherein each of the top wall, bottom wall, rear wall, right sidewall and left sidewall is an enclosing wall, and wherein an opening extends between the left sidewall and the right sidewall and between the top wall and the bottom wall and lying in a plane spaced from the rear wall, and wherein the opening is sized to receive the plurality of instrument trays;
(b) having an enclosing wall and at least one door defining an interior volume sized to receive at least one instrument tray retaining the contents;
(c) moving the door from an open position to a closed position to seal the sterilization container;
(d) venting the sterilization container through a venting pass through area having a filter occluding the venting passage area, wherein a ratio of the venting pass through area to the interior volume is at least 4 square inches to 250 cubic inches; and
(e) obtaining a drying of the contents in the sterilization container in less than 30 minutes.

US Pat. No. 10,391,430

FILTER ASSEMBLY

Haier US Appliance Soluti...

1. A filter assembly, comprising:a manifold;
a filter cartridge removably mounted to the manifold, the filter cartridge comprising
a first cartridge component; and
a second cartridge component joined to the first cartridge component at a failure interface such that the second cartridge component moves relative to the first cartridge component when the filter cartridge fails, the failure interface comprising a predicted stress concentration area that plastically deforms when the filter cartridge fails while the filter cartridge is mounted to the manifold;
an RFID tag mounted to the second cartridge component; and
an MD reader capable of signal communication with the RFID tag, the RFID reader positioned and oriented such that signal communication between the MD tag and the UM reader is interrupted when the filter cartridge fails and the second cartridge component moves relative to the first cartridge component,
wherein the second cartridge component and the first cartridge component are joined together at the failure interface such that the second cartridge component is fixed relative to the first cartridge component, the second cartridge component fracturing from the first cartridge component at the failure interface when the filter cartridge fails while the filter cartridge is mounted to the manifold.

US Pat. No. 10,391,428

PRESSURE FILTER WITH A FLOW DISTRIBUTOR AND A METHOD FOR WASHING THE PRESSURE FILTER

Andritz Oy, Helsinki (FI...

1. A pressure filter comprising:a container connected to an inlet conduit including an inlet configured to be coupled to a source of pressurized feeding liquor in a chemical pulp mill, and connected to an outlet configured to discharge a thickened suspension of the container;
an impervious plate separating an upper chamber of the container and a lower chamber of the container, wherein the inlet and the outlet are aligned with the lower chamber;
an opening in the impervious plate;
a filter tube extending through and filling the opening, the filter tube including a sidewall, bottom and an upper region, wherein the opening is aligned with the upper chamber and at least a portion of the sidewall and bottom extending into the lower chamber is porous so as to be impervious to at least some solids in the feeding liquor and allow liquids in the lower chamber to flow into the upper chamber, and
a flow distributor within an interior filter chamber defined by the sidewall of the filter tube, wherein the flow distributor has a cross-sectional area configured to create a backpressure in the interior filter chamber,
wherein the flow distributor includes a circular plate having a diameter smaller than an inner diameter of the interior filter chamber such that an opening is formed between a perimeter of the circular plate and the interior filter chamber, and the circular plate abuts an inner wall of the interior filter chamber, and
the flow distributor includes an elongated leg located in the interior filter chamber, the elongated leg includes an upper end section supporting the circular plate and a lower end section seated at the bottom of the filter tube such that the elongated leg stands on the bottom to support the circular plate,
wherein the circular plate and the upper end section of the elongated leg are below an upper region of the filter tube and at an elevation above a middle elevation of the filter tube, and the upper end section of the elongated leg is below and not directly connected to the impervious plate.

US Pat. No. 10,391,425

FLUIDIC DEVICE AND DEGASSING METHOD

Siemens Healthcare Diagno...

1. A fluid system comprising:a fluidic device;
a fluid control device connected to the fluidic device for controlling a flow of liquid in the fluidic device, the fluid control device comprising
a pressure sensor for measuring a pressure in the fluidic device for monitoring a pressure profile indicating the pressure in the fluidic device over time,
at least one pump connected to the fluidic device, and
a feedback control for controlling the pressure based on the monitored pressure profile by selectively activating the pump; and
a plurality of membranes disposed at a plurality of degassing areas of the fluidic device for removing gas contained in the liquid,
wherein each of the plurality of membranes comprises a plurality of pores having different pore sizes,
wherein each of the plurality of membranes comprises two sides with one side facing the liquid,
wherein the fluid control device is configured to generate a positive pressure differential between the two sides of each of the plurality of membranes when activated, and
wherein each of the plurality of membranes are permeable to the gas contained in the fluidic device and is impermeable to the liquid in the fluidic device under the pressure differential.

US Pat. No. 10,391,424

FRACTION COLLECTOR

SHIMADZU CORPORATION, Ky...

1. A fraction collector comprising:a collection container section configured to set a collection container whose top is open so as to collect a sample flowing out of a detector of a liquid chromatograph; and
a moving section configured to move in a horizontal plane direction at above the collection container section,
wherein the moving section comprises:
a nozzle that is connected to a channel through which a liquid flowing out of the detector flows;
a nozzle holding section configured to hold the nozzle in such a way that a tip of the nozzle faces downward;
a waste port, whose top is open, configured to lead a waste liquid to a drain;
a waste port holding section configured to hold the waste port; and
a drive mechanism configured to move the nozzle holding section; and
a waste port drive motor,
wherein the waste port holding section is formed from an arm, extending in a horizontal direction, configured to hold the waste port at a position lower than the tip of the nozzle,
wherein the waste port drive motor is configured to move, by rotating the arm, the waste port to the position immediately below the tip of the nozzle and to a position different from the position immediately below the tip of the nozzle, and
wherein the nozzle tip and the waste port are configured to be moved together by the moving section.

US Pat. No. 10,391,421

TEMPERATURE-ASSISTED ON-COLUMN FOCUSING

1. A device comprising:a liquid chromatography column having a longitudinal length and including a sample introduction inlet, an outlet, a longitudinally-extending inlet segment having a first end and a second end, a longitudinally-extending focusing segment having a first end and a second end, and a longitudinally-extending separation segment having a first end a second end, wherein the first end of the inlet segment is longitudinally adjacent to the sample introduction inlet of the liquid chromatography column, the second end of the inlet segment is longitudinally adjacent to the first end of the focusing segment, the second end of the focusing segment is longitudinally adjacent to the first end of the separation segment, and the second end of the separation segment is longitudinally adjacent to the outlet of the liquid chromatography column, and wherein the inlet segment contains noninteracting, nonporous silica spheres and the focusing segment and the separation segment both contain particles that have a surface chemistry that is different than the noninteracting, nonporous silica spheres contained in the inlet segment;
at least one Peltier thermoelectric cooling element aligned along the focusing segment; and
a resistive heater aligned along the separation segment.

US Pat. No. 10,391,417

LIQUID MATERIAL VAPORIZATON APPARATUS

HORIBA STEC, Co., Ltd., ...

1. A liquid material vaporization apparatus comprising:a gas-liquid mixing part adapted to mix a liquid material and gas to produce a gas-liquid mixture; and
a vaporization part adapted to heat the gas-liquid mixture to vaporize the liquid material, wherein:
the gas-liquid mixing part has a gas-liquid mixture lead-out pipe for leading out the gas-liquid mixture;
the vaporization part has a heating pipe forming a heating flow path for heating the gas-liquid mixture;
a lead-out port of the gas-liquid mixture lead-out pipe is arranged in the heating flow path, and a fore end part of the gas-liquid mixture lead-out pipe forms a double pipe with the heating pipe such that an outer lateral surface of the gas-liquid mixture lead out pipe is separate from an inner lateral surface of the heating pipe; and
the gas-liquid mixture lead-out pipe has:
a uniform diameter along its length, or a nozzle at the fore end part of the gas-liquid mixture lead out pipe.

US Pat. No. 10,391,414

INTERACTIVE DEVICE WITH ADVANCING LEVELS OF COMMUNICATION CAPABILITY

INTERNATIONAL BUSINESS MA...

1. A cognitive system comprising:an interactive device with communication capability for communicating with a user, the interactive device comprising:
a memory;
a processing circuit communicatively coupled with the memory; and
wherein:
the interactive device includes different levels of communication capability for communicating with the user; and
the interactive device is configured to automatically change from one level of communication to another level of communication of the different levels of communication, based on occurrence of one or more specified conditions of user communication with the interactive device during user interaction with the interactive device, wherein:
the user is a specified user, and the interactive device is configured with biometric technology to authenticate the specified user, and the automatically changing is based on the occurrence of the one or more specified conditions of only the specified user communicating with the interactive device; and
another user can communicate with the interactive device, without effecting the adjusting from the one level of communication to the other level of communication.

US Pat. No. 10,391,412

AMUSEMENT RIDE WITH ROBOT SYSTEM

KUKA Deutschland GmbH, A...

1. An amusement ride, comprising:a robot system including at least one multi-link robot arm, the robot arm having a base and a passenger holder for transporting at least one person; and
a controller for controlling the robot system, the controller comprising:
a storage means for storing a boundary of a work space arrangement with at least one work space,
a distance means for determining a distance of the passenger holder from the work space arrangement, and
a safety means for determining maximum allowable motion components in at least two spatial directions depending on the determined distance.

US Pat. No. 10,391,405

APPLICATION INTERFACE FOR TRACKING PLAYER IDENTITY

MICROSOFT TECHNOLOGY LICE...

1. A method of communication between an electronic device and a remote service executed by a remote server system, said method comprising, at the electronic device:providing a sign in mechanism for a user to access an electronic device and a profile associated with the user, the profile including a username and a plurality of achievements earned by the user while running an application associated with the remote service;
caching offline user activity, on the electronic device, including earning of an achievement of the plurality of achievements, the offline user activity occurring during the running of the application on the electronic device by the user while the electronic device is not connected to the remote service; and
uploading to the remote service, when the electronic device is connected to the remote service subsequent to conclusion of the running of the application, data indicating the earned achievement for the user during the offline user activity.

US Pat. No. 10,391,403

GAME EXTENSIONS IN A GAMING ENVIRONMENT

SONY INTERACTIVE ENTERTAI...

1. A system, comprising:a server communicatively coupled to a computing device; and
one or more processors in said server, wherein said one or more processors are configured to:
dynamically determine, from a library of game extensions in a gaming environment, at least one game extension corresponding to a game,
wherein said game is selected based on a first user input received at said computing device; and
transmit said at least one game extension to said computing device,
wherein each of said at least one game extension is associated with at least one configurable action,
wherein said at least one configurable action is triggered based on user interaction with said at least one game extension at said computing device,
wherein said computing device adds a newly developed HyperText Markup Language (HTML) based game extension in said library for said dynamic determination of said at least one game extension, based on a usage of said HTML based game extension in said gaming environment,
wherein the newly developed HyperText Markup Language (HTML) based game extension is configured based on a specific configurable action, and wherein said specific configurable action is based on at least one of a user profile, user gaming preferences, user friends, or user communities of a user.

US Pat. No. 10,391,401

GAME SYSTEM, ITS CONTROL METHOD AND A NON-TRANSITORY STORING MEDIA READABLE ON A COMPUTER DEVICE

CAPCOM CO., LTD., Chuo-K...

1. A game system comprising:a game space generating unit generating a virtual game space where first and second characters act and displaying the game space with the first and second characters acting in the game space on a display unit connected to the game system;
a character control unit controlling the first and second characters;
a storage storing a plurality of action pattern routines including first to third action pattern routines, the first action pattern routine including first and second actions, the second action pattern routines including the first action; and
an action pattern set generating unit selecting the first action pattern routine, and determining an action modification condition to replace the first action pattern routine with the third action pattern routine,
wherein the character control unit controls the first character to perform routinely the first and second actions with the second action subsequent to the first action when the first action pattern routine is selected for the first character, and
wherein the character control unit controls the second character to perform the first action when the second action pattern routine is selected for the second character.

US Pat. No. 10,391,393

GAME CONTROLLER WITH STRUCTURAL BRIDGE

Wikipad, Inc., Simi Vall...

1. A combination comprising:a computing device;
a pair of confinement structures, the pair of confinement structures interacting with the computing device and adjacent at least two opposing sides of the computing device, but not more than three sides of the sides of the computing device, each of the pair of confinement structures comprising a communication link, each of the communication links configured for electronic communication with the computing device;
a rigid structural bridge disposed between and secured to the pair of confinement structures, the rigid structural bridge comprising a passageway between the pair of confinement structures, the passageway promotes electrical communication between the communication link of a first confinement structure of the pair of confinement structures and the computing device, the passageway further promotes electrical communication between the communication link of a second confinement structure of the pair of confinement structures and the computing device; and
a pair of electronic game control modules, each electronic game control module of the pair of electronic game control modules is secured to and interacts with a corresponding confinement structure of the pair of confinement structures, each electronic game control module in electronic communication with the communication link of its corresponding confinement structure, wherein each electronic game control module is a separate and distinct structure from each of their corresponding confinement structures, forming no structural portion of their corresponding confinement structures, and in which each of the pair of confinement structures are separate and distinct structures from the structural bridge, forming no structural portion of the structural bridge.

US Pat. No. 10,391,392

DIRECTIONAL WIRELESS COMMUNICATION

IGT, Las Vegas, NV (US)

1. A method of operating an electronic gaming machine, the method comprising:after an establishment of a wireless communication link between the electronic gaming machine and a portable electronic device, determining, by a controller supported by a cabinet of the electronic gaming machine, a wireless signal strength relative to the electronic gaming machine, said determination being based on wireless signal data received from the portable electronic device;
determining whether the wireless signal strength relative to the electronic gaming machine has decreased below a predetermined threshold level; and
responsive to the determination being that the wireless signal strength relative to the electronic gaming machine has decreased below the predetermined threshold level and independent of any other electronic gaming machines, terminating, by the controller, the wireless communication link between the electronic gaming machine and the portable electronic device.

US Pat. No. 10,391,387

PRESENTING DIGITAL CONTENT ITEM WITH TIERED FUNCTIONALITY

MICROSOFT TECHNOLOGY LICE...

1. A method of acquiring a video game including a plurality of content portions, the method comprising:receiving and loading into computer memory a first set of the content portions, the first set including less than an entirety of the content portions;
beginning a gameplay session by computer-executing a partial functionality version of the video game using the first set of the content portions before all of the plurality of content portions are received and while other of the plurality of content portions continue to be received;
receiving and loading into computer memory a second set of the content portions while the gameplay session continues and the partial functionality version of the video game continues computer-executing; and
adding functionality to the partial functionality version of the video game using the second set of content portions while the gameplay session continues and the partial functionality version of the video game continues computer-executing.

US Pat. No. 10,391,385

BOARD GAME APPARATUS

1. A board game apparatus comprising:a plurality of playing pieces and
a board having a plurality of playing piece receptacles, each receptacle having:
a playing piece support parallel to the board for supporting a respective one of the playing pieces parallel to the board,
a depression, and
a fulcrum between the support and the depression, the arrangement being such that pressing part of the playing piece into the depression lifts another part for lifting of the piece from the receptacle, wherein:
each receptacle is bordered on all sides by recesses perpendicular to the board, the recesses extending below the support of the receptacle which they border, and
each recess is complementary in shape to the playing pieces, and perpendicular to the board, such that playing pieces fit perpendicularly into the recesses bordering each playing piece receptacle and a respective one of the playing pieces in the playing piece receptacle, whereby these playing pieces edge the receptacle and the playing piece therein.

US Pat. No. 10,391,378

SMART-COURT SYSTEM AND METHOD FOR PROVIDING REAL-TIME DEBRIEFING AND TRAINING SERVICES OF SPORT GAMES

PLAYSIGHT INTERACTIVE LTD...

1. A Smart-court system, comprising:a computer programmed to implement:
a capture module for receiving a video stream of a sport session;
an object detector module, for extracting at least one object from frames of the video stream, for tracking at least one of the at least one extracted object as appearing in the video stream;
an event module for automatically analyzing motion of the tracked at least one object, for automatically identifying a plurality of events and classifying the identified events into types based on said tracking and analyzing, and for creating a synchronized event log of the classified events based on said identifying and classifying; and
a presentation module for allowing a user to selectively play at least one of the identified events classified into the types, by type, based on the synchronized event log.

US Pat. No. 10,391,377

BAR SECURING APPARATUS AND METHODS OF USE

1. A bar securing apparatus for securing a weight bar to a weight rack or rack component, consisting essentially of: an upper end; a lower end; and, a cut-out located between the upper end and the lower end, sized and shaped for placement of a weight bar with a circular cross-section therein, wherein each upper end and the lower end is configured with at least one attachment point for removably receiving pins for securing said apparatus to a weight rack or rack component.

US Pat. No. 10,391,375

BATTING STANCE TRAINING MAT

1. A batting stance training mat comprising:a center panel with a home plate indicia for designating home plate;
a first lateral panel and a second lateral panel each having a first terminal end and a second terminal end, wherein each lateral panel includes a plurality of indicia, wherein each of the plurality of indicia designates foot placement of a user relative to the home plate indicia;
an end panel having an indicia designating foot placement of a second user relative to the home plate indicia;
wherein the end panel extends past the second terminal end of each of the first and second lateral panel;
wherein the indicia of the end panel is a pair of shoe prints, wherein each shoe print has a toe end and heel end, wherein the toe end of each shoe print faces toward the center panel.

US Pat. No. 10,391,374

ELONGATED HAND THROWN PROJECTILE

1. An elongated hand thrown projectile, comprising:a projectile body having a rounded head at its forward end, a midsection comprising a support frame having opposing coplanar side walls defining a through pening therebetween, and a shaft at a rearward end, the midsection having a width substantially the diameter of the rounded head, wherein a projectile axis extends between the rounded head and the shaft;
a finger grip attached to the projectile body, the finger grip having a longitudinal grip axis extending perpendicular to the projectile axis, the finger grip having a length parallel to the grip axis that is substantially less than a length of the projectile; and
a thumb grip;
wherein: the thumb grip is attached to the projectile body at a position longitudinally forward of the finger grip.

US Pat. No. 10,391,369

GOLF CLUB

Taylor Made Golf Company,...

14. A golf club head comprising:a body having a face, a sole and a crown, the crown having a first portion having a first color or shade and a second portion having a second color or shade, the face, crown and sole together defining an interior cavity, the golf club body including a heel and a toe portion and having an x, y and z axis which are orthogonal to each other having their origin at USGA center face;
and
wherein the golf club head has a primary alignment feature comprising a paint or masking line which delineates a transition between at least a first portion of the crown having an area of contrasting shade or color with a shade or color of the face;
and
wherein the club head further comprises a secondary alignment feature comprising a paint or masking line which delineates the transition between the first portion of the crown and the second portion of the crown having an area of contrasting shade or color with the shade or color of the first portion of the crown;
wherein the secondary alignment feature has a Sight Adjusted Perceived Face Angle Secondary Alignment Feature, (“SAPFASAF”) of from about ?2 to about 6 degrees;
wherein the golf club head has a CGx of 0 to about ?4 mm;
wherein at least one of the sole and crown is at least in part a composite material;
wherein the golf club head has a z-axis moment of inertia (Izz) of 480 to 600 Kg·mm2 and an x-axis moment of inertia (Ixx) of about 280 to 420 Kg·mm2.

US Pat. No. 10,391,367

ADJUSTABLE SOLE WEIGHT OF A GOLF CLUB HEAD

Karsten Manufacturing Cor...

1. A golf club head comprising:a body having a heel portion, a toe portion, a sole portion, and an outer surface;
a strikeface having a geometric center;
a head center of gravity; and
a weight member having opposing first and second ends; wherein
the weight member is configured to be positioned adjacent to the sole portion of the club head, substantially flush with the outer surface of the body;
the weight member is repositionable by the user to a first position or a second position;
a weight member axis extends through a geometric center of the weight member, longitudinally and symmetrically dividing a width of the weight member along the entire length,
the weight member comprises a weight member axis that forms a weight member angle relative to a z-axis extending through the head center of gravity from the strikeface to the rear portion parallel to a ground plane when the club head is at an address position and the z-axis is perpendicular to the strikeface, the weight member angle ranges from 3 to 20 degrees, the weight member comprises a weight pad, and the weight pad is asymmetric with respect to the weight member axis; wherein
the club head having the weight member in the first position shifts the head center of gravity toward the strikeface, and
the club head having the weight member in the second position shifts the head center of gravity away from the strikeface, such that on impact with a golf ball at the geometric center of the strikeface, the club head having the weight member in the first position applies a first vertical spin on the golf ball and the club head having the weight member in the second position applies a second vertical spin on the golf ball such that the second vertical spin is different than the first vertical spin.

US Pat. No. 10,391,364

CLAY REINFORCED DUAL CORE A GOLF BALL

Callaway Golf Company, C...

1. A method for forming a core for a golf ball, the method comprising:mixing at least 60 weight percent of a polybutadiene, 10-50 weight percent of zinc diacrylate, 1-30 weight percent of zinc oxide, 1-20 weight percent of zinc stearate, 0.1-10 weight percent of a peroxide initiator, 0-10 weight percent of zinc pentachlorothiophenol, and 0.4 to 2.5 weight percent of an octadecyl amine (ODA) modified clay material; and
compression molding a core from the core mixture.

US Pat. No. 10,391,363

GOLF BALLS HAVING A FOAM LAYER OF A CROSS-LINKED THERMOPLASTIC COMPOSITION

Acushnet Company, Fairha...

1. A golf ball, comprising a core assembly and a cover, the core assembly comprising:i) an inner core layer comprising a foam composition, the inner core having a geometric center, outer region, and outer surface, the geometric center and outer regions being foamed and the foam composition comprising a cross-linked acid copolymer of ethylene and an ?,?-unsaturated carboxylic acid and the outer surface being a non-foamed skin layer having a thickness in the range of about 0.001 inches to about 0.500 inches, wherein the foam composition is formed by reacting: a) an acid copolymer of ethylene and an ?,?-unsaturated carboxylic acid, b) a metallic acrylate salt, and c) a peroxide free-radical initiator;
wherein the inner core layer has an overall diameter in the range of about 0.100 to about 1.100 inches and an outer surface hardness (Hinner core surface) and a center hardness (Hinner core center), the Hinner core surface being greater than the Hinner core center to provide a positive hardness gradient in the inner core; and
ii) an outer core comprising a non-foamed thermoset or thermoplastic composition, the outer core layer being disposed about the inner core layer and having a thickness in the range of about 0.100 to about 0.750 inches, and an outer surface hardness (Houter surface of OC), wherein the (Houter surface of OC) is greater than the (Hinner core center) to provide a positive hardness gradient across the core assembly.

US Pat. No. 10,391,362

SOFT POLYURETHANE COATING FOR A GOLF BALL

Callaway Golf Company, C...

1. A coating comprising:a part A component comprising an acrylic polyol, a BEPD polyol, a 3-Oxazolidineethanol, a fluorosurfactant, a hindered amine light stabilizer, a UV-absorber, an optical brightener, a dibutyltin dilaurate catalyst, a first organic solvent, and a second organic solvent; and
a part B component comprising an aliphatic polyisocyanate, and a third organic solvent selected from the group consisting of n-butyl acetate, t-butyl acetate, ethyl acetate, methyl amyl ketone and methyl isobutyl ketone.

US Pat. No. 10,391,358

IMPACT AND SOUND ANALYSIS FOR GOLF EQUIPMENT

Karsten Manufacturing Cor...

10. A system for determining an impact location of a golf ball on a face of a golf club, comprising:a motion sensor including at least one of a gyroscope or an accelerometer for generating motion sensor data relating to motion of the golf club;
wherein the motion sensor is mounted on the golf club below a center of gravity of the golf club;
a computing apparatus including a processor;
memory storing computer readable instructions that, when executed, cause the computing apparatus to:
receive data generated from an impact of a golf ball against a face of the golf club, wherein the data includes the motion sensor data generated by the motion sensor;
analyze the motion sensor data from the impact to determine one or more characteristics of the impact between the golf ball and the face of the golf club, including filtering the motion sensor data, generating a response spectrum from the filtered motion sensor data; and
generate an output specifying an impact location of the golf ball on the face of the golf club; and
an output device providing at least one of visual, audio, textual, or haptic information relating to the impact location of the golf ball on the face of the golf club;
wherein analyzing the motion sensor data from the impact further comprises (a) comparing the response spectrum to a first reference response spectrum for a first location on the face of the golf club and (b) comparing the response spectrum to a second reference response spectrum for a second location on the face of the golf club upon determining that the response spectrum does not match the first reference response spectrum.

US Pat. No. 10,391,352

TUBE RACK-OUTS FOR USE WITH EXERCISE MACHINE

HOIST FITNESS SYSTEMS, IN...

1. A support apparatus, comprising:a hollow support structure having an aperture therein;
an angled tubular member, the angled tubular member having a first end received into the aperture in the hollow support and a second end that is angled upwardly; and
a cover passing over an upper surface of the angled tubular member, the cover being connected onto the hollow support structure,
wherein the support structure has a pair of slots on a side opposite to the aperture and the angled tubular member has notches thereon that are received into the slots.

US Pat. No. 10,391,351

FUNCTIONAL TRAINING EQUIPMENT WITH MULTIPLE MOVEMENT PLANES FOR BICEPS CURL EXERCISE

1. A biceps curl machine comprising:a resistance element;
a user support coupled to the resistance element;
a first movement element coupled to the user support, the first movement element comprising:
a first column disposed below the user support; and
a first connecting element comprising a first pivot point such that the user support is able to pivot about a first axis associated with the first connecting element, wherein the first connecting element is movably coupled to the first column such that the first connecting element is able to move along the first column; and
a second movement element coupled to a back of the user support, the second movement element comprising:
a second column disposed parallel to and proximal to the back of the user support; and
a second connecting element comprising a second pivot point such that the user support is able to pivot about a second axis associated with the second connecting element, wherein the second connecting element is movably coupled to the second column such that the second connecting element is able to move along the second column.

US Pat. No. 10,391,348

ADJUSTABLE RESISTANCE AND BRAKING SYSTEM FOR EXERCISE EQUIPMENT

Mad Dogg Athletics, Inc.,...

1. An adjustable magnetic resistance system for an indoor cycle comprising:a flywheel that includes two circumferential disks that are located a distance apart and that extend radially outwardly from the flywheel; and
a movable arm that includes at least one magnet and that may be raised and lowered in relation to the flywheel and in between the circumferential disks.

US Pat. No. 10,391,346

ABUSE POTENTIAL REDUCTION IN ABUSABLE SUBSTANCE DOSAGE FORM

Verde Environmental Techn...

1. A method for reducing potential for substance abuse from a skin-worn transdermal patch device comprising an abusable substance layer containing residual amounts of an abusable substance of interest after removal from a user, the method comprising:inserting the transdermal patch device into a container and thereby contacting the abusable substance layer of the transdermal patch device as removed from a user to an anti-abuse substance present in an anti-abuse layer that is attached to an interior wall of the container, wherein the anti-abuse substance is selected from the group consisting of co-soluble antagonists, irritants and combinations thereof so that the potential for abuse is reduced.

US Pat. No. 10,391,339

FALL PROTECTION DEVICE

YOKE INDUSTRIAL CORP., T...

1. A fall protection device, comprising:a frame, including a first lateral plate and a second lateral plate which face each other, wherein the first lateral plate includes an exterior surface which faces toward a direction away from the second lateral plate, and a stopping block is formed on the exterior surface;
a rotation unit, rotatably disposed between the first lateral plate and the second lateral plate of the frame;
a safety belt, wound around the rotation unit and disposed between the first lateral plate and the second lateral plate; the safety belt is adapted to be pulled to drive the rotation unit to rotate;
a braking plate, engaged with the rotation unit and including an interior surface which faces the exterior surface of the first lateral plate;
a braking block, pivotally disposed on the interior surface of the braking plate and located between the interior surface of the braking plate and the exterior surface of the first lateral plate; the braking block includes a stopping part which would pivotally swing from a closed position to an expanding position by centrifugal force to abut against the stopping block as the braking plate rotates and thereby restrict the rotation of the rotation unit; and
a restoring spring, connected between the braking block and the braking plate to drive the braking block to move back to the closed position.

US Pat. No. 10,391,332

KIT FOR IMMOBILIZATION OF A HUMAN'S BODY PART

1. A kit for immobilization of a patient body part for radiotherapy applications comprising two moldable thermoplastic sheets, a lower sheet for covering the anatomical contours of a first area of said body part and an upper sheet for covering the anatomical contours of a second area of said body part which is not covered by the lower sheet thereby forming a double shell mask enclosing said body part, wherein the sheets are configured to be connected and retained by a fixation device; and wherein said sheets have different physical properties and wherein the yield strain ratio of the lower sheet to the upper sheet is from 0.005 to 0.03.

US Pat. No. 10,391,327

ELECTRODE ARRANGEMENT FOR PLASMA TREATMENT AND DEVICE FOR PRODUCING A TRANSCUTANEOUS CONNECTION

1. An electrode arrangement for an antiseptic dielectric barrier discharge plasma treatment of an area on a skin surface, comprising:a planar electrode;
a dielectric embodied as a planar material, wherein the planar electrode is fastened to the dielectric in such a way that a layer of the dielectric shields the planar electrode from the skin surface;
a skin penetration piece providing skin penetration and having a longitudinal axis, a proximal end, and a distal end, the skin penetration piece being configured as an adapter to fasten an exoprosthesis to a bone of a residual limb, the skin penetration piece being connectable to the bone at the proximal end and to the exoprosthesis at the distal end;
a ring-shaped contact surface that is formed by the dielectric and is provided for fastening to the skin penetration piece, the ring-shaped contact surface facing towards the skin surface when the skin penetration piece is arranged to penetrate the skin surface;
a barrier discharge plasma positioned between the ring-shaped contact surface and the skin surface;
wherein the dielectric, together with the planar electrode, surrounds and is permanently connected to the skin penetration piece, the ring-shaped contact surface is at an angle >20° in relation to the longitudinal axis, and the dielectric and the planar electrode have a radial slit formed therein and having a partial circular construction, the radial slit providing mounting of the planar electrode with the dielectric to the skin penetrating piece;
wherein the electrode arrangement is configured to provide regular treatment of the skin surface while the planar electrode and dielectric are attached to the skin penetration piece.

US Pat. No. 10,391,323

DOSED DELIVERY OF AUTONOMIC MODULATION THERAPY

Cardiac Pacemakers, Inc.,...

1. A method for providing a dosed delivery of a neural stimulation therapy, comprising:receiving a signal indicative of a user programmable neural stimulation dose for the neural stimulation therapy;
delivering the neural stimulation therapy to a target of a patient;
controlling delivery of the neural stimulation therapy to provide the user programmable neural stimulation dose; and
displaying a dose meter on a display to provide an indicator of a total charge delivered over a period of time for the neural stimulation therapy, and the indicator of the total charge is for a current user programmable neural stimulation dose for the neural stimulation therapy, or for a user proposed neural stimulation dose for the neural stimulation therapy, or for both the current user programmable neural stimulation dose and the user proposed neural stimulation dose.

US Pat. No. 10,391,321

SYSTEMS, METHODS, AND DEVICES FOR EVALUATING LEAD PLACEMENT BASED ON GENERATED VISUAL REPRESENTATIONS OF SACRUM AND LEAD

NUVECTRA CORPORATION, Pl...

1. A method of evaluating an implantation of a lead that is configured to deliver electrical stimulation to a patient, the method comprising:obtaining visual representations of a sacrum of the patient and the lead that is implanted in the sacrum; and
evaluating a placement of the lead by analyzing the visual representations of the sacrum and the lead to determine whether one or more of the following factors are met:
a first factor involving which foramen of the sacrum the lead is implanted in;
a second factor involving how far the lead is coming out of a pelvic floor of the patient; or
a third factor involving how bent the lead is.

US Pat. No. 10,391,318

CAPTURE MANAGEMENT DURING LEFT VENTRICULAR PACING THERAPY IN A CARDIAC MEDICAL DEVICE AND MEDICAL DEVICE SYSTEM

Medtronic, Inc., Minneap...

1. A method of determining capture during delivery of a ventricular pacing therapy in a medical device system, comprising:sensing a subcutaneous cardiac signal and emitting a trigger signal in response to the sensed cardiac signal;
delivering the ventricular pacing therapy to the left ventricle in response to the emitted trigger signal;
comparing a beat of the subcutaneous cardiac signal sensed subsequent to the ventricular pacing therapy being delivered to the left ventricle to a baseline intrinsic template associated with a non-paced beat; and
determining whether the delivered ventricular pacing therapy captures the left ventricle in response to the comparing:
determining whether the device is in a VDD pacing mode or a VVI pacing mode;
determining a timing window including the sensed beat in response to determining whether the device is in the VDD pacing mode or the VVI pacing mode;
wherein the comparing step comprises comparing the sensed beat within the timing window to the baseline intrinsic template and determining a correlation between the sensed beat within the timing window and the baseline intrinsic template; and
wherein the step of determining whether the delivered ventricular pacing therapy captures the left ventricle comprises determining whether the delivered ventricular pacing therapy captures the left ventricle in response to the correlation.

US Pat. No. 10,391,317

SYSTEMS AND METHODS FOR CARDIO-RESPIRATORY PACING

Cardiac Pacemakers, Inc.,...

1. A method for pacing a patient's heart using a leadless cardiac pacemaker (LCP), comprising:a circuit of the LCP recognizing each of a plurality of R-waves and determining a sampling window following at least some of the recognized R-waves;
sampling a signal generated by an accelerometer of the LCP during at least some of the sampling windows;
determining, by the LCP, based at least in part on the sampled signals, that a current posture of the patient corresponds to a predetermined sleep posture, and in response, the LCP:
determining a respiration phase of the patient based at least in part on the signal generated by the accelerometer of the LCP;
pacing the patient's heart at a pacing rate that is modulated based at least in part on the determined respiration phase of the patient; and
determining, by the LCP, based at least in part on the sampled signals, that the current posture of the patient does not correspond to the predetermined sleep posture, and in response the LCP:
pacing the patient's heart at a pacing rate that is not dependent on the respiration phase of the patient.

US Pat. No. 10,391,312

APPARATUS AND METHOD FOR OCULAR MICROCURRENT STIMULATION THERAPY

i-Lumen Scientific, Inc.,...

1. An apparatus comprising:a disposable therapy appliance that includes:
a strip of material containing a plurality of electrodes configured to apply microcurrent stimulation therapy to a patient, wherein each electrode is no larger than 36 mm2, wherein the strip is shaped to be positioned to place electrodes on an upper eyelid and a lower eyelid of the patient's skin for a treatment session, wherein the strip is bifurcated such that the strip includes a first elongated portion that is adapted to be placed on the upper eyelid and a second elongated portion that is adapted to be placed on the lower eyelid, and wherein each one of the plurality of electrodes is configured to be individually activated at a time for microcurrent stimulation without activation of any other ones of the plurality of electrodes during that time.

US Pat. No. 10,391,311

COCHLEAR IMPLANTS

Advanced Bionics AG, Sta...

1. A cochlear implant, comprising:a cochlear lead including a flexible body, a plurality of electrodes on the flexible body, and a plurality of wires within the flexibly body respectively connected to the plurality of electrodes;
an antenna;
a processor case including
a multi-piece structure that includes
a base with a bottom wall and first and second side walls that together define a one-piece, unitary structure,
a first end wall, attached to the bottom wall and to the first and second side walls, including a first plurality of feedthrough pins having first ends respectively connected to the plurality of lead wires and second ends,
a second end wall, attached to the bottom wall and to the first and second side walls, including a second plurality of feedthrough pins having first ends connected to the antenna and second ends,
the base and the first and second end walls including respective features that facilitate alignment of the base with the first and second end walls, and
a cover attached to the first and second side walls and to the first and second end walls; and
a printed circuit board assembly located within the processor case and including a printed circuit board, a processor on the printed circuit board, a first plurality of electrical contacts respectively connected to the second ends of the first plurality of feedthrough pins and second plurality of electrical contacts respectively connected to the second ends of the second plurality of feedthrough pins.

US Pat. No. 10,391,308

MRI-SAFE IMPLANTABLE MEDICAL DEVICE

Medtronic, inc., Minneap...

1. A medical system, comprising:a stimulator for generating electrical stimulation therapy; and
a lead coupled to the stimulator, the lead comprising:
an implantable elongate insulating body;
an electrode on a distal end of the insulating body; and
an electrical conductor within the insulating body that is connected to the electrode, the conductor having a calculated absolute impedance greater than 15 ohms per centimeter at 64 MHz.

US Pat. No. 10,391,307

MRI AND RF COMPATIBLE LEADS AND RELATED METHODS OF OPERATING AND FABRICATING LEADS

Boston Scientific Neuromo...

1. A flexible medical lead, comprising:an elongate flexible lead body of a biocompatible polymer material, the lead body having a length with a proximal end portion and a distal end portion;
a plurality of electrodes disposed along the distal end portion of the lead body;
a plurality of contacts disposed along the proximal end portion of the lead body; and
at least one conductor, wherein each of the at least one conductor is continuous and is electrically coupled to at least one of the electrodes and at least one of the contacts and comprises a plurality of segments, each segment comprising a multi-layer stacked coil configuration, each multi-layer stacked coil configuration comprising a first forward coiled section that extends in a forward lengthwise direction, then turns back into a reverse coiled section that extends in a substantially opposing reverse lengthwise direction, then turns back into a second forward coiled section that extends in the forward lengthwise direction, wherein the first forward coiled section, reverse coiled section, and second forward coiled section form a plurality of layers stacked over each other.

US Pat. No. 10,391,304

NEUROSTIMULATION LEAD WITH STIFFENED PROXIMAL ARRAY

Boston Scientific Neuromo...

1. An implantable electrical lead, comprising:a lead body having a proximal end and a distal end;
a plurality of contacts disposed along the distal end of the lead body;
a plurality of terminals disposed along the proximal end of the lead body;
a plurality of conductors axially extending within the lead body and coupling the contacts to the terminals; and
a stiffening tube disposed within the proximal end of the lead body and beneath at least one of the terminals, wherein the stiffening tube defines a lumen extending through the stiffening tube and the stiffening tube terminates proximal to all of the contacts.

US Pat. No. 10,391,286

BILIARY TRACT DRAINAGE TUBE

NATIONAL UNIVERSITY CORPO...

1. A biliary tract drainage tube used to drain a biliary tract from a patient body, comprising:an external drainage tube that is inserted from one of a nose and mouth of the patient body to be placed in a digestive tract, having a first length longitudinally determined between a distal end and a base end, the based end being opposite to the distal end, wherein the first length is large enough to allow the base end to be placed outside the patient body by passing through the one of the nose and mouth while the distal end remains inside a common bile duct of the patient body, and
an internal drainage tube that is provided on a tip of the external drainage tube so as to be separable from the external drainage tube, having a second length longitudinally determined between a leading end and a trailing end, the tailing end being opposite to the leading end, wherein the leading end is defined as an end closer to the distal end of the external drainage tube than the trailing end, and the second length is large enough to allow the trailing end to protrude into a duodenum of the patient body when the leading end is arranged inside intrahepatic bile ducts of the patient body, wherein
the external drainage tube comprises a main body portion and a narrow-diameter portion that is provided closer to the distal end of the external drainage tube than the main body portion and longitudinally extends toward the distal end,
the narrow-diameter portion is integrally formed with the main body portion so as to have an outer diameter that is narrower than an outer diameter of the main body portion such that a step is formed at a boundary between the main body portion and the narrow-diameter portion,
the narrow-diameter portion has a third length longitudinally determined between the distal end of the external drainage tube and the step at the boundary, and the outer diameter of the narrow-diameter portion is narrower than an inner diameter of the internal drainage tube over the third length such that the narrow-diameter portion is inserted into the inner diameter tube, and the trailing end of the internal drainage tube contacts to the step at the boundary, allowing the internal drainage tube to be pushed forward with the step while the biliary tract drainage tube is inserted into the patient body, and allowing the internal drainage tube to be detached from the narrow-diameter portion when the biliary tract drainage tube is pulled off the patient body.

US Pat. No. 10,391,285

MOTION-ASSISTED SYSTEMS, DEVICES AND METHODS FOR MINIMIZING OBSTRUCTION OF MEDICAL DEVICES

THE CLEVELAND CLINIC FOUN...

1. A device comprising:a body configured to attach to a medical device in an operative state, the medical device having a lumen or hollowed portion, the body comprising:
a housing including a motor configured to deliver mechanical motion to the medical device along the lumen or hollowed portion in a manner configured to induce a swirling motion in liquids being transported through the lumen, the swirling motion in the liquids being sufficient to prevent biological substances from adhering to the inner walls of the lumen or hollowed portion of the medical device and thereby minimize obstruction of the medical device's lumen or hollowed portion.

US Pat. No. 10,391,282

GUIDEWIRES AND METHODS FOR PERCUTANEOUS OCCLUSION CROSSING

1. A method, comprising:advancing a distal end portion of a guidewire through the natural lumen of a blood vessel to a location near an occlusion, including advancing a core member with a distal end portion comprising a first segment having a first longitudinal stiffness and a second segment more distal than the first segment and having a second longitudinal stiffness greater than the first longitudinal stiffness;
applying a longitudinal force greater than the first longitudinal stiffness to a proximal end portion of the guidewire, including causing the first segment of the distal end portion to prolapse, wherein the first segment has a length in a range of 0.05 cm to 1 cm, inclusive, and the first longitudinal stiffness ranges from 0.2 g to 6 g, inclusive; and
further advancing the distal end portion of the guidewire through or around the occlusion, led by the prolapsed segment.

US Pat. No. 10,391,281

EXPANDABLE SHEATH

Edwards Lifesciences Corp...

1. A kit for implanting a heart valve, the kit comprising:a heart valve and an expandable sheath, the expandable sheath comprising:
an expandable outer member including a lumen extending therethrough;
an inner member extending longitudinally within the lumen of the outer member, the inner member defining a central lumen of the sheath and including a folded portion comprising one or more folds, each of the one or more folds comprising portions of the inner member arranged in an overlapping configuration that move to a less overlapping configuration increasing a diameter of the central lumen of the sheath;
a second folded portion circumferentially spaced around the inner member from the folded portion;
a third folded portion circumferentially spaced around the inner member from the folded portion and the second folded portion, wherein the folded portion, second folded portion and third folded portion are equally spaced circumferentially around the inner member; and
at least two reinforcing members extending longitudinally along a length of the sheath and located radially outward of the folded portion and the second folded portion;
wherein the inner and outer member are configured to expand to allow passage of the heart valve through the central lumen of the inner member, and
wherein expansion of the sheath causes a circumferential distance between the at least two reinforcing members to increase from a first circumferential distance to a second circumferential distance.

US Pat. No. 10,391,279

EXPANDABLE SHEATH

Edwards Lifesciences Corp...

1. A sheath comprising:an expandable outer member including a lumen extending therethrough;
an inner member extending longitudinally within the lumen of the outer member, the inner member defining a central lumen of the sheath and including a folded portion comprising one or more folds, each of the one or more folds comprising portions of the inner member arranged in an overlapping configuration that move to a less overlapping configuration increasing a diameter of the central lumen of the sheath;
a second folded portion circumferentially spaced around the inner member from the folded portion;
a third folded portion circumferentially spaced around the inner member from the folded portion and the second folded portion, wherein the folded portion, second folded portion and third folded portion are equally spaced circumferentially around the inner member; and
at least two reinforcing members extending longitudinally along a length of the sheath and located radially outward of the folded portion and the second folded portion;
wherein the inner and outer members are configured to expand; and
wherein expansion of the sheath causes a circumferential distance between the at least two reinforcing members to increase from a first circumferential distance to a second circumferential distance.

US Pat. No. 10,391,277

SYSTEMS AND METHODS FOR 3D STEREOSCOPIC ANGIOVISION, ANGIONAVIGATION AND ANGIOTHERAPEUTICS

Voxel Rad, Ltd., Irvine,...

1. An ionizing radiation-free method to navigate within body structures to cardiac tissue ablation targets, the method comprising:capturing and loading a digital image identifying a vascular system of a patient into a memory storage device, the digital image acquired without using ionizing radiation and iodinated agents, the digital image comprising a magnetic resonance angiogram (MRA) including images of the vascular system and at least one infrared (IR) marker placed external to the patient prior to acquiring the digital image, the digital image further including images of the at least one IR marker taken by two IR cameras, each IR camera capturing the image of the at least one IR marker from a different position with respect to the patient;
generating stereotactic coordinates in a stereotactic coordinate system based at least in part on the digital image, locations of the at least one IR marker detected by the MRA and the two IR cameras, and an entry point of a first catheter, the locations of the at least one IR marker providing registration information for the stereotactic coordinate system, the first catheter including a first camera operationally coupled to a first fiber optic bundle and at least one electromagnetic sensor associated with an electromagnetic coordinate system;
generating from the digital image a 3D rendering of the patient's vascular system in stereotactic space, the 3D rendering including an indication of the entry point and a cardiac ablation target using the stereotactic coordinate system;
generating a roadmap from the entry point to the cardiac ablation target on the 3D rendering;
co-registering the electromagnetic and the stereotactic coordinate systems in order to fuse positional information of the at least one electromagnetic sensor with the 3D rendering;
obtaining a position associated with the first catheter from an in-room global positioning system (GPS) configured to track the at least one electromagnetic sensor;
fusing the position associated with the first catheter on the 3D rendering, the position comprising the longitudinal, lateral, anterior-posterior, pitch, roll, and yaw location of the first catheter;
displaying the 3D rendering including indications for the position of the first catheter, the cardiac ablation target, the entry point, and the roadmap, the 3D rendering used to navigate the first catheter to the cardiac ablation target, the first camera providing an angioscopic view of the cardiac ablation target.

US Pat. No. 10,391,275

SYSTEMS, DEVICES AND METHODS FOR DRAINING AND ANALYZING BODILY FLUIDS

Potrero Medical, Inc., H...

1. A drainage assembly configured to prevent negative pressure build-up, comprising:an elongate catheter having a first end configured for insertion within a body lumen, the catheter having at least one opening near or at the first end in fluid communication with a catheter lumen defined therethrough;
a drainage lumen in fluid communication with a second end of the catheter;
a reservoir in fluid communication with the drainage lumen, wherein the reservoir defines a tortuous path which inhibits bubbles from flowing through the tortuous path;
an overflow area in fluid communication with the reservoir, wherein the overflow area is configured to drain fluid from the reservoir when excess fluid enters into the reservoir;
a venting mechanism in fluid communication with the drainage lumen, wherein the venting mechanism includes a vent tube;
a valve positioned within the venting mechanism and configured to maintain a closed position until a first pressure level within the drainage lumen is dropped to a second pressure level such that the valve moves to an open position;
a vent positioned in fluid communication with the valve, wherein the venting mechanism is configured to inhibit wetting of the vent from fluid within the drainage lumen; and
a controller in communication with the reservoir, wherein the controller is configured to apply a negative pressure to the drainage lumen to drop the first pressure level to the second pressure level such that the valve is moved to the open position and wherein the controller is further configured to determine a fluid volume collected within the reservoir.

US Pat. No. 10,391,273

SLEEP APNEA DEVICE TO POSITIVELY BLOCK EXHALING AND METHOD OF USE

The Regents of the Univer...

1. A respiratory apparatus comprising:a pair of nasal tube devices configured with relatively rigid tubular bodies for receipt in a patient's nasal passages to cooperate in locking air flow, the bodies configured with through air-flow passages and formed with respective proximal and distal extremities, the bodies including respective rim devices formed with respective proximally facing peripheral valve seats;
respective membranes having marginal edges configured to be, when the devices are disposed in the nasal passages, responsive to the pressure differential generated by the patient inhaling to be shifted from respective open positions off the respective seats to provide for air flow through the air-flow passages and further responsive to the patient exhaling to close the marginal edges on the respective seats to fully block exhaling from the respective nasal passages;
retaining devices carried from the respective tube devices to mount the respective membranes for shifting from the respective open to the closed positions; and
relatively soft, pliable sheaths received over the respective tubular bodies and projecting proximally beyond the respective proximal extremities to form respective cushioning rings.

US Pat. No. 10,391,272

EXPANDABLE INTER-VIVOS TUBE

1. An expandable inter-vivos tube comprising:a tube element comprising:
at least one slit extending along a longitudinal axis of the tube element from a proximal end to a distal end of the tube element;
a plurality of slots positioned along an edge of each of the at least one slit, each slot arranged at an angle with respect to the longitudinal axis;
a slider associated with, and spanning across each of the at least one slit, the slider, arranged along an inner surface of the tube element, extending along the longitudinal axis toward the distal end, said slider comprising:
an edge element configured to be positioned outside the proximal end of the tube element; and
a plurality of nipples, each of the nipples engaging a corresponding one of the plurality of slots, wherein each nipple extends from the inner surface of the tube element through a corresponding one of the plurality of slots toward an outer surface of the tube element.

US Pat. No. 10,391,265

ANESTHESIA APPLICATORS/INJECTORS FOR DENTAL AND OTHER APPLICATIONS AND METHODS OF USE

1. An apparatus, comprising:an elongated tubular body;
a coupling disposed on a first end of the elongated tubular body, the coupling configured to at least secure the elongated tubular body to a reservoir including a liquid medication;
a cannula extending through the elongated tubular body, the cannula having an open distal end, the cannula further being in fluid communication with
a passageway extending through the coupling from the reservoir; and
a hollow skirt disposed on a second end of the elongated tubular body, the hollow skirt being in fluid communication with the open distal end of the cannula, the hollow skirt having an edge configured to form a substantially fluid tight seal with an outer surface of a gingiva, the substantially fluid tight seal enabling a delivery of a first dose of the liquid medication from the reservoir to the gingiva before a second dose of the liquid medication is delivered through the cannula penetrating the gingiva.

US Pat. No. 10,391,247

MEDICAMENT DELIVERY DEVICE

SHL Medical AG, Zug (CH)...

1. A medicament delivery device comprising:a housing arranged to accommodate a medicament container;
a drive unit operably arranged to act on said medicament container for expelling a dose of medicament;
an activation unit operably connected to said drive unit for activating said drive unit;
said drive unit comprising an actuation element arranged movable inside the housing from an initial position prior to activation, to a displaced position after activation;
a first near-field communication chip (NFC-chip) comprising first information;
a second NFC-chip comprising second information; and
at least one shielding element arranged to said housing, wherein said at least one shield element is arranged to shield the first NFC-chip and to allow reading of the second NFC-chip when said actuation element is in the initial position, and wherein said at least one shield element is arranged to shield said second NFC-chip and to allow reading of said first NFC-chip when said actuation element is in the displaced position.

US Pat. No. 10,391,244

USE ACTIVATED EMERGENCY ALERT FOR A MEDICAL DEVICE

1. A medication injection device, comprising:an actuator configured for direct engagement by a user for manual generation of an injection force;
a medicinal reservoir for storing a quantity of medication for injection;
a plunger responsive to the actuator for displacing the medication in the medicinal reservoir;
a housing containing the plunger, the actuator slidably disposed within a bore in the housing;
a needle in fluidic communication with the medicinal reservoir for transporting the displaced medication through an aperture in a distal end of the needle;
an electrical coupling responsive to movement of the actuator for initiating an alert signal upon closure of the electrical coupling, the alert signal configured for transmission to a first responder in anticipation of an exigent response for further medical attention, the movement corresponding to plunger travel for dispensing the medication in the medicinal reservoir,
the electrical coupling defined by opposed contacts attached to the actuator and a circular conductor defined by the bore, the opposed contacts adapted to electrically connect to the circular conductor upon disposing the actuator through the bore;
a circuit board affixed to the housing for initiating the alert signal;
and
a connection from the circuit board to the opposed contacts.

US Pat. No. 10,391,242

DIABETES THERAPY MANAGEMENT SYSTEM FOR RECOMMENDING BOLUS CALCULATOR ADJUSTMENTS

MEDTRONIC MINIMED, INC., ...

1. An insulin infusion system comprising:an insulin infusion device; and
an electronic device comprising:
a processor device; and
at least one memory element associated with the processor device, the at least one memory element storing processor-executable instructions that, when executed by the processor device, perform a method of managing use of the insulin infusion device, the method comprising:
receiving glucose data for a user of the insulin infusion device, the glucose data indicating blood glucose levels of the user for a plurality of days and for periods of time during which the insulin infusion device is regulating delivery of insulin to the user;
reviewing the received glucose data to identify bolus calculator event data corresponding to use of a bolus calculator of the insulin infusion device, wherein the reviewing uses a pattern recognition technique on the received glucose data, wherein the bolus calculator calculates each bolus dosage recommendation based on a respective user-entered carbohydrate consumption value, a respective user-entered current blood glucose value, a user-specific insulin sensitivity value, and a user-specific carbohydrate ratio value;
filtering the identified bolus calculator event data to isolate correction bolus events having no food bolus component or a minimal food bolus component, wherein the filtering uses a pattern recognition technique on the identified bolus calculator event data;
filtering the identified bolus calculator event data to isolate food bolus events having no correction bolus component or a minimal correction bolus component, wherein the filtering uses a pattern recognition technique on the identified bolus calculator event data;
analyzing the isolated correction bolus events to check for event occurrences that are indicative of potential maladjustment of the insulin sensitivity value;
analyzing the isolated food bolus events to check for event occurrences that are indicative of potential maladjustment of the carbohydrate ratio value;
wherein event occurrences are checked in a predetermined sequence, utilizing a prioritization scheme to ensure that conflicting recommendations are not provided and to make only one recommendation at a time;
determining, based on the analyzing and the prioritization scheme, that a particular recommendation corresponding to a detected event occurrence is needed;
outputting a first recommendation and one or more commands to the insulin infusion device to adjust the insulin sensitivity value in response to the determining, and in response to detection of an event occurrence indicative of potential maladjustment of the insulin sensitivity value; and
outputting a second recommendation and one or more commands to the insulin infusion device to adjust the carbohydrate ratio value in response to the determining, and in response to detection of an event occurrence indicative of potential maladjustment of the carbohydrate ratio value;
wherein the insulin infusion device automatically adjusts the insulin sensitivity value in accordance with the one or more commands for the first recommendation, or automatically adjusts the carbohydrate ratio value in accordance with the one or more commands for the second recommendation, and
wherein the predetermined sequence includes checks performed in the following order:
(1) check for long term hypoglycemia, post-bolus;
(2) check for short term hypoglycemia, post-bolus;
(3) check for long term high glycemic variability;
(4) check for short term high glycemic variability;
(5) check for long term hyperglycemia; and
(6) check for short term hyperglycemia.

US Pat. No. 10,391,240

BLOOD COLLECTION ASSEMBLY HAVING A HINGED SHIELD

Becton, Dickinson and Com...

1. A needle assembly comprising:a housing having proximal and distal ends;
a cannula having an IV end projecting distally from the housing and a non-patient end projecting proximally from the housing; and
a single IV shield comprising a pair of spaced-apart sidewalls that define a space for receiving a portion of the IV end of the cannula, the IV shield pivotally secured to the housing and having a pre-use position, in which the IV shield covers a portion of the IV end of the cannula, and a use position, in which the IV shield is adapted to move between a non-shielded position and a shielded position,
wherein each of the sidewalls includes a pair of projections adapted to temporarily hold the distal end of the housing therebetween when the IV shield is in the pre-use position.

US Pat. No. 10,391,234

TUBING ASSEMBY

BAYER HEALTHCARE LLC, Wh...

1. A tubing assembly for use with a fluid delivery system, the tubing assembly comprising:a first fluid line having a distal end and a proximal end for connecting to a first fluid source;
a second fluid line having a distal end and a proximal end for connecting to a second fluid source;
a third fluid line having a distal end and a proximal end;
a connector assembly for connecting the distal end of the first fluid line and the distal end of the second fluid line to the proximal end of the third fluid line; and
a tubing holder for receiving at least a portion of the third fluid line, the tubing holder having a first portion and a second portion the tubing holder further comprising a first connector having a first filling port and a second connector having a second filling port, wherein the proximal end of the first fluid line is fluidly connected to the first connector and the proximal end of the second fluid line is fluidly connected to the second connector;
wherein the first portion of the tubing holder is connected to the second portion of the tubing holder by a hinge such that the second portion is movable relative to the first portion between a first, open position and a second, closed position;
wherein, when the tubing holder is in the second, closed position, the at least the portion of the third fluid line is pinched or folded by the first portion and the second portion to block the fluid flow through the third fluid line.

US Pat. No. 10,391,229

FLUID CONVEYANCE SAFETY DEVICES, METHODS, AND SYSTEMS

Nxstage Medical, Inc., L...

1. A method of providing vascular access, the method comprising:withdrawing blood from a patient through a first cannula;
infusing blood into a patient through a second cannula;
withdrawing blood through a secondary channel affixed to the second cannula such that a withdrawal of the second cannula from the patient is necessarily attended by a disruption of fluid communication through the loss of patency;
generating an alarm signal responsively to air being drawn into the secondary channel.

US Pat. No. 10,391,228

AIR PURGING SYSTEMS FOR BLOOD TREATMENTS

BAXTER INTERNATIONAL INC....

1. A hemodialysis system configured to purge air from a blood circuit, the hemodialysis system comprising:a dialyzer;
a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including
a fresh dialysis fluid pump,
a used dialysis fluid pump,
a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and
a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;
the blood circuit in fluid communication with the dialyzer and including
an arterial line for removing blood from a patient and delivering the blood to the dialyzer,
a venous line for returning blood from the dialyzer to the patient,
a blood pump operable with the arterial line upstream of the dialyzer,
a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump,
a drip chamber located along the venous line, and
a container for accepting air purged from the blood circuit; and
an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, the blood pump drives air from the drip chamber into the container.

US Pat. No. 10,391,226

AIR BUBBLE REMOVAL FROM EXTRACORPOREAL BLOOD VIA CHEMICAL ENTRAPMENT OF NITROGEN

International Business Ma...

1. A process comprising removing air bubbles from extracorporeal blood via chemical entrapment of nitrogen (N2) gas, wherein the chemical entrapment includes dinitrogen fixation by an organometallic complex.

US Pat. No. 10,391,211

NEGATIVE PRESSURE WOUND THERAPY ORTHOPEDIC DEVICE

Ossur Iceland ehf, Reykj...

1. A negative pressure wound therapy (NPWT) orthopedic device comprising:a base shell having a posterior portion and a plantar portion, the base shell defining an opening over a dorsal aspect thereof;
a dorsal shell contoured to generally correspond to the opening of the base shell, the dorsal shell including a proximal section and a distal section, the proximal section at least in part defining a receiving space; and
a NPWT system including a pump mechanism secured in the receiving space, a wound covering situated inside of the base shell and arranged to form a sealed volume over a wound area of a user, and at least one conduit forming a fluid connection between the wound covering and the pump mechanism, wherein the pump mechanism is arranged to apply a negative pressure to the wound area through the at least one conduit;
wherein a cutout is formed in the dorsal shell and the receiving space is defined by a cover member removably attached over the cutout.

US Pat. No. 10,391,208

INSTILLATION CARTRIDGE AND THERAPY SYSTEM FOR NEGATIVE-PRESSURE THERAPY AND INSTILLATION THERAPY

KCI Licensing, Inc., San...

51. An apparatus for providing installation therapy and negative-pressure therapy, the apparatus comprising:a housing;
a moveable barrier disposed in the housing to form a dosing chamber and a pressure chamber;
a therapy conduit configured to be fluidly coupled to a pressure source and to a canister;
a fluid inlet fluidly coupled to the dosing chamber and configured to be fluidly coupled to a fluid source;
a fluid outlet fluidly coupled to the dosing chamber and configured to be fluidly coupled to a dressing;
a pressure inlet fluidly coupled to the therapy conduit and the pressure chamber;
a biasing element disposed in the dosing chamber, coupled to the moveable barrier, and operable to move the moveable barrier between a discharge position and a charge position; and
a check valve in the therapy conduit.

US Pat. No. 10,391,204

FREE-STANDING BIODEGRADABLE PATCH

BioInspire Technologies, ...

1. A device for treatment comprising:a film that is biocompatible, biodegradable, and adapted to adhere to tissue at or adjacent to a sinus of a patient, the film integrally formed, prior to adherence to the tissue, of at least a first adhesive layer comprising an amount of unreacted, purified human fibrinogen prepared without excipients selected to transition the film to a temporary gel state upon exposure to an aqueous environment, the first adhesive layer adjoined to a second layer comprising and a therapeutic agent configured to be released into the tissue, the first adhesive layer further comprising a plasticizer in an amount of up to 0.5 mg per mg of fibrinogen,
wherein, in the temporary gel state, the film is freely manipulatable and deformable to adhere to the tissue.

US Pat. No. 10,391,198

MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES

Adhesys Medical GmbH, Aa...

1. A formulation for staunching the loss of blood (haemostatic) or tissue fluids comprising:A) an isocyanate-functional prepolymer obtained from
A1) an aliphatic isocyanate and
A2) a polyol component having a number-average molecular weight of greater than or equal to 400 g/mol and an average OH functionality of 2 to 6,
B) a curing component comprising
B1) an amino-functional aspartic ester of the general formula (I)

where
X is an organic radical obtained by removing the primary amino groups from 2-methyl 1,5-diaminopentane;
R1 and R2 are ethyl and
n is 2;
B2) optionally, organic fillers which have a viscosity as measured to DIN 53019 at 23° C. in the range from 10 to 6000 mPas,
and
C) optionally, reaction products of isocyanate-functional prepolymers as defined for component A) with aspartic esters as per component B1) and/or organic fillers as per component B2).

US Pat. No. 10,391,194

ACTIVE PHOTOCATALYTIC OXIDATION

DBG GROUP INVESTMENTS, LL...

1. A photocatalytic oxidation system comprising:a housing having a longitudinal central axis;
a UV bulb having a central axis that is parallel with the longitudinal central axis, the UV bulb positioned and configured to emit UV radiation radially about the central axis and into the housing;
a first active cell panel positioned on a first side of the housing and parallel with the longitudinal central axis, the first active cell panel comprising
an inner surface that faces inward toward the longitudinal central axis and incorporates a plurality of elongate apertures having interior surfaces,
wherein the inner surface of the first active cell panel and at least one of the interior surfaces of the plurality of elongate apertures are coated with a photocatalytic material configured to exhibit a photocatalytic oxidative process when subjected to UV radiation emitted from the UV bulb;
a first side panel positioned on a second side of the housing and parallel with the longitudinal central axis, the first side panel comprising
a first reflective feature that includes a convex protrusion that protrudes from an inner surface of the first side panel inward toward the longitudinal central axis, the first reflective feature extending longitudinally on the inner surface of the first side panel for a length that coincides with the first active cell panel but is shorter than the first active cell panel so as to define an airway disposed at an end of the first reflective feature, the airway longitudinally coinciding with at least a portion of the first active cell panel to thereby allow a portion of the air passing through the active cell panel to pass through the airway uninterrupted by the first reflective feature, and
wherein the surface of the first reflective feature is configured to reflect UV radiation emitted from the UV bulb, in the direction of the first side panel, toward the inner surface of the first active cell panel and at least one of the interior surfaces of the plurality of elongate apertures of the first active cell panel.

US Pat. No. 10,391,192

AUTOMOTIVE VENT FRESHENER

Scent2Market Inc., Yonke...

1. A securement for a freshener device, comprising:a clip comprising a post member configured for temporary securement to an ancillary object; and
a carrier retainer configured to secure a carrier to a portion of the clip, wherein the carrier retainer comprises a pin with a bulbous shaped retainer head, the clip and the carrier retainer being a unitary piece.

US Pat. No. 10,391,179

ORGANOMODIFIED CARBOSILOXANE MONOMERS CONTAINING COMPOSITIONS AND USES THEREOF

Momentive Performance Mat...

1. A silicone composition comprising of at least one carbosiloxane linkage having thefollowing formula

wherein the silicone composition has improved hydrolytic stability.

US Pat. No. 10,391,177

METHODS FOR TREATING CANCER USING 6,8-BIS (BENZYLTHIO) OCTANONIC ACID

Rafael Pharmaceuticals, I...

1. A method of treating a cancer selected from the group consisting of a carcinoma, sarcoma, myeloma, lymphoma, leukemia, a mixed type thereof, and a cancer of the pancreas in a human patient in need thereof, comprising the step of intravenously administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of 6,8-bis(benzylthio)octanoic acid or an ion pair thereof, and a pharmaceutically acceptablediluent for solubilizing 6,8-bis(benzylthio)octanoic acid or an ion pair thereof.

US Pat. No. 10,391,130

COMPOSITIONS COMPRISING BACTERIAL STRAINS

4D PHARMA RESEARCH LIMITE...

1. A method of reducing inflammation associated with Th17 cell differentiation in a subject having a disorder mediated by the Th17 pathway, comprising administering to the subject a pharmaceutical composition that comprises a bacteria strain of the genus Bacteroides, wherein the administering reduces inflammation associated with Th17 cell differentiation in the subject, andwherein the bacteria strain comprises a polynucleotide sequence of a 16S rRNA gene that has at least 95% sequence identity to the polynucleotide sequence of SEQ ID NO:4, as determined by a Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12, a gap extension penalty of 2, and a Blocks Substitution Matrix (BLOSUM) of 62.

US Pat. No. 10,391,112

CATIONIC POLYMERS AS CO-DRUGS FOR CHEMOTHERAPEUTIC AGENTS

NORTHWESTERN UNIVERSITY, ...

1. A method for treating a biological cell, the method comprising:administering a composition of matter to a biological sample, wherein the composition of matter comprises a mixture of:
a chemotherapeutic drug and polyethyleneimine (PEI), wherein the chemotherapeutic drug is not covalently bound to the PEI;
and wherein the composition of matter exhibits greater cytotoxicity than either the chemotherapeutic drug or PEI individually and has a molar ratio of between 2:1 and 5:1 (moles of the PEI: moles of the chemotherapeutic drug).

US Pat. No. 10,391,111

COMPOSITION FOR PREVENTING OR TREATING CERVICAL CANCER INCLUDING GYPENOSIDE LXXV

Intelligent Synthetic Bio...

1. A method for preventing or treating cervical cancer, comprising a step of administering a pharmaceutical composition comprising gypenoside LXXV represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient:

US Pat. No. 10,391,099

METHOD OF TREATING PSORIATIC ARTHRITIS, PSORIASIS, AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH A NOVEL 2,5-SUBSTITUTED PYRIMIDINES

GRUENENTHAL GMBH, Aachen...

1. A method of treating a condition or disease in a subject comprising administering to the subject a 2,5-substituted pyrimidine having the following general formula (I)whereinA, B, C each independently of each other stands for N or CH;
R1 stands for (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-haloalkyl, (C3-C6)-cycloalkyl, SOx—(C1-C6)-alkyl, CONH2, CONH—(C1-C6)-alkyl, or CON((C1-C6)-alkyl)2;
x is 0, 1 or 2;
G is an optionally with at least one substituent Y substituted phenyl or 5- or 6-membered heteroaryl which comprises at least one oxygen, sulfur or nitrogen atom, whereas the nitrogen atoms present in the heteroaryl can be substituted with R4;
R4 is hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, CO—(C1-C6)-alkyl, SO(C1-C6)-alkyl, SO2(C1-C6)-alkyl;
Y independently of one another is halogen, OH, CN, SH, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkinyl, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-thioalkyl, (C1-C6)-haloalkyl, (C1-C6)-thiohaloalkyl, (C1-C6)-haloalkoxy, CO2H, CO2(C1-C6)-alkyl, CHO, CO(C1-C6)-alkyl, OCO(C1-C6)-alkyl, CONH2, CONH—(C1-C6)-alkyl, CON((C1-C6)-alkyl)2, OCO—NH(C1-C6)-alkyl, OCO—N((C1-C6)-alkyl)2, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, NH—CO—(C1-C6)alkyl, NH—CO2(C1-C6)-alkyl, N(C1-C6)-alkyl-CO2(C1-C6)-alkyl, NH—CO—NH2, NH—CO—NH(C1-C6)-alkyl, NH—CO—N(C1-C6)-alkyl)2, N(C1-C6)-alkyl-CO—NH2, N(C1-C6)alkyl-CO—NH(C1-C6)-alkyl, N(C1-C6)-alkyl-CO—N((C1-C6)-alkyl)2, NH—SO2—(C1-C6)-alkyl, N(C1-C6)alkyl-SO2—(C1-C6)-alkyl, S—(C1-C6)-alkyl, SO(C1-C6)-alkyl, SO2—(C1-C6)-alkyl, SO2H, SO2OH, SO2NH2, SO2NH(C1-C6)-alkyl, SO2N((C1-C6)-alkyl)2, C(?N)—NH, NHC(?N)—NH2, —N?C?O, —S—CN, wherein the aforementioned alkyl chains may be substituted with at least one of the following substituents OH, CN, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy, CO2H, CO2(C1-C6)-alkyl or —NH2;
R2 and R3,
independently of one another stand for hydrogen or optionally substituted (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-alkoxy (C1-C6)-alkylen, (C1-C6)-alkylen-CO2H, (C1-C6)-alkylen-CO2(C1-C6)-alkyl, (C1-C6)-alkylen-CONH2, (C1-C6)-alkylen-CONH(C1-C6)-alkyl, (C1-C6)-alkylen-CON((C1-C6)-alkyl)2, (C1-C6)-alkylen-(C3-C6)-cycloalkyl, (C1-C6)-hydroxyalkyl-(C3-C6)-cycloalkylen, a group L1V, or a group L2W, or
together with the nitrogen atom to which they are attached form an optionally with at least one substituent XQ substituted 3- to 12-membered mono- or bicyclic heteroaliphatic residue Q which may additionally contain at least one oxygen, sulfur or further nitrogen atom, whereas these one or more additional nitrogen atoms are substituted with R5;
XQ independently of each other stand for ?O (carbonyl), halogen, OH, CN, SH, (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-cyanoalkyl, (C2-C6)-alkenyl, (C2-C6)-alkinyl, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy(C1-C6)-alkylen, (C1-C6)-thioalkyl, (C1-C6)-haloalkyl, (C1-C6)-thiohaloalkyl, (C1-C6)-haloalkoxy, —NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, (C1-C6)-alkylen-NH(C1-C6)-alkyl, (C1-C6)-alkylen-N((C1-C6)-alkyl)2 NH—CHO, NH—CO(C1-C6)-alkyl, N(C1-C6)-alkyl-CO(C1-C6)-alkyl, NH—CO—O(C1-C6)-alkyl, N(C1-C6)-alkyl-CO—O(C1-C6)-alkyl, NH—CO—NH2, NH—CO—NH(C1-C6)-alkyl, NH—CO—N((C1-C6)-alkyl)2, N(C1-C6)-alkyl-CO—NH2, N(C1-C6)-alkyl-CO—NH(C1-C6)-alkyl, N(C1-C6)-alkyl-CO—N((C1-C6)-alkyl)2, NH—SO2—(C1-C6)-alkyl, N(C1-C6)-alkyl-SO2—(C1-C6)-alkyl, CO2H, CO2(C1-C6)-alkyl, CHO, CO(C1-C6)-alkyl, O—CO(C1-C6)-alkyl, CO—NH2, CO—NH(C1-C6)-alkyl, CO—N((C1-C6)-alkyl)2, O—CO—NH(C1-C6)-alkyl, O—CO—N((C1-C6)-alkyl)2, S—(C1-C6)-alkyl, SO(C1-C6)-alkyl, SO2—(C1-C6)-alkyl, SOOH, SO2OH, SO2NH2, SO2NH(C1-C6)-alkyl, SO2N((C1-C6)-alkyl)2, C(?N)—NH, NHC(?N)—NH2, —N?C?O, or —S—CN, wherein the aforementioned alkyl chains may be substituted with at least one of the following substituents OH, CN, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy, CO2H, CO2(C1-C6)-alkyl or —NH2;
R5 is hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, CO—(C1-C6)-alkyl, SO—(C1-C6)-alkyl, SO2—(C1-C6)-alkyl;
L1 is a bond or a branched or straight-chain optionally substituted (C1-C6)-alkylene group connected to the amide nitrogen;
V is an optionally with at least one substituent Xv substituted 3- to 12-membered mono- or bicyclic aliphatic or heteroaliphatic residue, whereas if one or more nitrogen atoms are present in the mono- or bicyclic heteroaliphatic residue, then at least one of these nitrogen atoms is substituted with R6;
XV independently of each other stand for ?O (carbonyl), halogen, OH, CN, SH, (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-cyanoalkyl, (C2-C6)-alkenyl, (C2-C6)-alkinyl, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy(C1-C6)-alkylen, (C1-C6)-thioalkyl, (C1-C6)-haloalkyl, (C1-C6)-thiohaloalkyl, (C1-C6)-haloalkoxy, —NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, (C1-C6)-alkylen-NH(C1-C6)-alkyl, (C1-C6)-alkylen-N((C1-C6)-alkyl)2 NH—CHO, NH—CO(C1-C6)-alkyl, N(C1-C6)-alkyl-CO(C1-C6)-alkyl, NH—CO—O(C1-C6)-alkyl, N(C1-C6)-alkyl-CO—O(C1-C6)-alkyl, NH—CO—NH2, NH—CO—NH(C1-C6)-alkyl, NH—CO—N((C1-C6)-alkyl)2, N(C1-C6)-alkyl-CO—NH2, N(C1-C6)-alkyl-CO—NH(C1-C6)-alkyl, N(C1-C6)-alkyl-CO—N((C1-C6)-alkyl)2, NH—SO2—(C1-C6)-alkyl, N(C1-C6)-alkyl-SO2—(C1-C6)-alkyl, CO2H, CO2(C1-C6)-alkyl, CHO, CO(C1-C6)-alkyl, O—CO(C1-C6)-alkyl, CO—NH2, CO—NH(C1-C6)-alkyl, CO—N((C1-C6)-alkyl)2, O—CO—NH(C1-C6)-alkyl, O—CO—N((C1-C6)-alkyl)2, S—(C1-C6)-alkyl, SO(C1-C6)-alkyl, SO2—(C1-C6)-alkyl, SOOH, SO2OH, SO2NH2, SO2NH(C1-C6)-alkyl, SO2N((C1-C6)-alkyl)2, C(?N)—NH, NHC(?N)—NH2, —N?C?O, or —S—CN, wherein the aforementioned alkyl chains may be substituted with at least one of the following substituents OH, CN, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy, CO2H, CO2(C1-C6)-alkyl or —NH2;
R6 is hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, CO—(C1-C6)-alkyl, SO(C1-C6)-alkyl, or SO2(C1-C6)-alkyl;
L2 is a bond or a branched or straight-chain optionally substituted (C1-C6)-alkylene group connected to the amide nitrogen;
W is an optionally with at least one substituent Z substituted phenyl or 5- or 6-membered heteroaryl which contains at least one oxygen, sulfur or nitrogen atom; and
Z independently of each other stand for halogen, OH, CN, SH, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkinyl, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-thioalkyl, (C1-C6)-haloalkyl (C1-C6)-thiohaloalkyl, (C1-C6)-haloalkoxy, —NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, NH—CHO, NH—CO(C1-C6)-alkyl, N(C1-C6)-alkyl-CO(C1-C6)-alkyl, NH—CO2(C1-C6)-alkyl, N(C1-C6)-alkyl-CO2(C1-C6)-alkyl, NH—CO—NH2, NH—CO—NH(C1-C6)-alkyl, NH—CO—N((C1-C6)-alkyl)2, N(C1-C6)-alkyl-CO—NH2, N(C1-C6)-alkyl-CO—NH(C1-C6)-alkyl, N(C1-C6)-alkyl-CO—N((C1-C6)-alkyl)2, NH—SO2—(C1-C6)-alkyl, N(C1-C6)-alkyl-SO2—(C1-C6)-alkyl, CO2H, CO2(C1-C6)-alkyl, CHO, CO(C1-C6)-alkyl, O—CO(C1-C6)-alkyl, CO—NH2, CO—NH(C1-C6)-alkyl, CO—N((C1-C6)-alkyl)2, O—CO—NH(C1-C6)-alkyl, O—CO—N((C1-C6)-alkyl)2, S—(C1-C6)-alkyl, SO(C1-C6)-alkyl, SO2—(C1-C6)-alkyl, SO2H, SO2OH, SO2NH2, SO2NH(C1-C6)-alkyl, SO2N((C1-C6)-alkyl)2, C(?N)—NH, NHC(?N)—NH2, —N?C?O, or —S—CN, wherein the aforementioned alkyl chains may be substituted with at least one of the following substituents OH, CN, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy, CO2H, CO2(C1-C6)-alkyl or —NH2,
wherein the 2,5-substituted pyrimidine having the general formula (I) is in its presented form or in its acid or base form, or in the form of a physiologically tolerable salt, or in its solvate form, or in the form of a racemate, a pure stereoisomer, enantiomer or diastereomer,
wherein the condition or disease is selected from the group consisting of psoriatic arthritis, psoriasis, and chronic obstructive pulmonary disease.

US Pat. No. 10,391,095

DNA-PK INHIBITORS

VERTEX PHARMACEUTICALS IN...

1. A method of sensitizing a cell to an agent that induces a DNA lesion comprising contacting the cell with a compound having the formula:or a pharmaceutically acceptable salt thereof, whereinQ is N or CH;
R1 is hydrogen, CH3, CH2CH3, or R1 and the carbon to which it is bound form a C?CH2 group;
Ring A is a ring system selected from

RA1 is hydrogen, halogen, C1-4alkyl, C0-4alkyl-C3-6cycloalkyl, C0-4alkyl-ORA1a, C0-4alkyl-SRA1a, C0-4alkyl-C(O)N(RA1a)2, C0-4alkyl-CN, C0-4alkyl-S(O)—C1-4alkyl, C0-4alkyl-S(O)2—C1-4alkyl, C0-4alkyl-C(O)ORA1b, C0-4alkyl-C(O)C1-4alkyl, C0-4alkyl-N(RA1b)C(O)RA1a, C0-4alkyl-N(RA1b)S(O)2RA1a, C0-4alkyl-N(RA1a)2, C0-4alkyl-N(RA1b)(3-6 membered-cycloalkyl), C0-4alkyl-N(RA1b)(4-6 membered-heterocyclyl), N(RA1b)C2-4alkyl-N(RA1a)2, N(RA1b)C2-4alkyl-ORA1a, N(RA1b)C1-4alkyl-(5-10 membered heteroaryl), N(RA1b)C1-4alkyl-(4-6 membered heterocyclyl), N(RA1b)C2-4alkyl-N(RA1b)C(O)RA1a, C0-4alkyl-N(RA1b)C(O)C1-4alkyl, C0-4alkyl-N(RA1b)C(O)OC1-4alkyl, C0-4alkyl-(phenyl), C0-4alkyl-(3-10 membered-heterocyclyl), C0-4alkyl-C(O)-(4-6 membered-heterocyclyl), C0-4alkyl-O—C0-4alkyl-(4-6 membered-heterocyclyl), C0-4alkyl-(5-6 membered-heteroaryl), C0-4alkyl-C(O)-(5-6 membered-heteroaryl), C0-4alkyl-O—C0-4alkyl-(5-6 membered-heteroaryl), C0-4alkyl-N(RA1a)(4-6 membered-heterocyclyl), or C0-4alkyl-N(RA1b)(5-6 membered-heteroaryl), wherein each of said RA1 heterocyclyl is a ring system selected from aziridinyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, dioxanyl, dioxolanyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, pyrrolidinedionyl, morpholinyl, piperidinyl, piperazinyl, piperazinonyl, tetrahydrothiophenedioxidyl, 1,1-dioxothietanyl, 2-oxa-6-azaspiro[3.4]octanyl, or isoindolinonyl wherein each of said RA1 heteroaryl is a ring system selected from furanyl, thiophenyl, imidazolyl, benzoimidazolyl, oxazolyl, oxadiazolyl, thiazolyl, pyrazolyl, thiadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, triazolyl, or tetrazolyl, and wherein each of said RA1 alkyl, cycloalkyl, phenyl, heterocyclyl, or heteroaryl groups is optionally substituted with up to three F atoms, up to two C1-2alkyl groups, a C3-6cycloalkyl group, a phenyl group, a benzyl group, an alkenyl-C0-2alkyl group, an alkynyl-C0-2alkyl group, up to two C0-2alkyl-ORA1b groups, a C0-2alkyl-N(RA1b)2 group, a SC1-4alkyl group, a S(O)2C1-4alkyl group, a C(O)RA1b group, a C(O)ORA1b group, a C(O)N(RA1b)2 group, a —CN group, or a C4-6heterocyclic ring system selected from oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, or morpholinyl;
each RA1a is, independently, hydrogen, C1-4alkyl, C3-6cycloalkyl, C4-6heterocyclyl selected from oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, or piperidinyl, C5-6heteroaryl selected from imidazolyl, triazolyl, tetrazolyl, pyrazolyl, thiophenyl, thiazolyl, pyridinyl, pyrimidinyl, or pyrazinyl, or two RA1a and an intervening nitrogen atom form a 3-6 membered heterocyclic ring selected from aziridinyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, piperidinyl, piperidinonyl, tetrahydropyridinyl, piperazinyl, or morpholinyl, wherein each of said RA1a alkyl, cycloalkyl, heterocyclyl, or heteroaryl groups is optionally substituted with up to three F atoms, up to two C1-2alkyl groups, a C3-6cycloalkyl group, up to two C0-2alkyl-ORA1b groups, a C0-2alkyl-N(RA1b)2 group, a SC1-4alkyl group, a C(O)RA1b group, a C(O)ORA1b group, a C(O)N(RA1b)2 group, or a —CN group;
each RA1b is, independently, hydrogen, C1-2alkyl, or C3-4cycloalkyl;
RA2 is hydrogen, C1-4alkyl, C0-4alkyl-C3-6cycloalkyl, C0-2alkyl-(4-6 membered)heterocyclyl, C2-4alkyl-ORA2a, C0-2alkyl-C(O)N(RA2a)2, C0-2alkyl-S(O)2—C1-4alkyl, C0-2alkyl-C(O)OC1-4alkyl, C0-2alkyl-C(O)-(4-6 membered)heterocyclyl, wherein each of said heterocyclyl is selected from oxetanyl, tetrahydropyranyl, tetrahydrofuranyl, dioxanyl, dioxolanyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, pyrrolidinedionyl, morpholinyl, piperidinyl, piperazinyl, piperazinonyl, or 1,1-dioxothietanyl, and each of said RA2 groups except hydrogen is optionally substituted with up to three F atoms, up to two C1-2alkyl groups, a C3-6cycloalkyl group, an alkenyl-C0-2alkyl group, an alkynyl-C0-2alkyl group, up to two ORA2b groups, a C0-2alkyl-N(RA2b)2 group, a SC1-4alkyl group, a S(O)2C1-4alkyl group, a C(O)RA2b group, a C(O)ORA2b group, a C(O)N(RA2b)2 group, or a —CN group;
each RA2a is, independently, hydrogen, C1-4alkyl, a C5-6heteroaryl selected from imidazolyl, triazolyl, tetrazolyl, pyrazolyl, thiophenyl, thiazolyl, pyridinyl, pyrimidinyl, or pyrazinyl, or two RA2a and an intervening nitrogen atom form a 3-6 membered heterocyclic ring selected from aziridinyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, piperidinyl, piperidinonyl, tetrahydropyridinyl, piperazinyl, or morpholinyl;
each RA2b is, independently, hydrogen, C1-4alkyl, or C3-4cycloalkyl;
RA3 is hydrogen or C1-2alkyl;
each RA4 is, independently, deuterium, halogen, CN, C1-4alkyl, or OC1-4alkyl, wherein each RA4 alkyl is optionally substituted with up to 3 F atoms, two non-geminal OH groups, or one OC1-2alkyl, or two RA4 together with an intervening saturated carbon atom form a spiral cyclopropyl or cyclobutyl ring;
n is 0-3;
Ring B is a ring system selected from

RB1 is hydrogen, C1-4alkyl, (CH2)0-1C3-6cycloalkyl, C(O)C1-2alkyl, (CH2)0-1-(4-6 membered)heterocyclyl ring wherein said heterocyclic ring is selected from selected from oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, dioxanyl, dioxolanyl, or pyrrolidinonyl, phenyl, benzyl, or (CH2)1-2(5-6 membered)heteroaryl ring wherein said heteroaryl ring is selected from pyridinyl, imidazolyl, or pyrazolyl, and wherein each of said RB1 alkyl, cycloalkyl, phenyl, benzyl, heterocyclyl or heteroaryl groups is optionally substituted with up to 3 F atoms, up to two C1-2alkyl groups, two non-geminal OH groups, or one OC1-2alkyl;
RB2 is hydrogen, C1-4alkyl, OC1-4alkyl;
each RB3 is, independently, hydrogen, halogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, CN, C(O)H, C(O)C1-4alkyl, C(O)OC1-4alkyl, C(O)C1-4alkyl, C(O)NH2, C(O)NHC1-4alkyl, C(O)NH(CH2)0-1C3-6cycloalkyl, C(O)NHCH2oxetanyl, C(O)NHCH2tetrahydrofuranyl, C(O)NHCH2tetrahydropyranyl, C(O)NHphenyl, C(O)NHbenzyl, C(O)NHOH, C(O)NHOC1-4alkyl, C(O)NHO(CH2)0-1C3-6cycloalkyl, C(O)NHO(CH2)0-1oxetanyl, C(O)NHO(CH2)0-1tetrahydrofuranyl, C(O)NHO(CH2)0-1tetrahydropyranyl, C(O)NHOphenyl, C(O)NHObenzyl, NH2, NHC(O)C1-4alkyl, OC1-4alkyl, SC1-4alkyl, S(O)C1-4alkyl, or a 5-membered-heteroaryl ring system selected from furanyl, thiophenyl, imidazolyl, pyrrole, pyrazolyl, and oxadiazolyl, wherein each RB3 group except hydrogen or halogen is optionally substituted with Cl, up to three F atoms, up to two non-geminal OH groups, up to two OC1-2alkyl, one NH2, one NHC1-2alkyl, one NHC(O)C1-2alkyl, or one N(C1-2alkyl)2;
each RB4 is, independently, hydrogen, halogen, C1-4alkyl, OC1-4alkyl, SC1-4alkyl, NH2, NH(C1-4alkyl), N(C1-4alkyl)2, NHC(O)C1-4alkyl, C(O)OH, C(O)OC1-4alkyl, C(O)NH2, C(O)NHC1-4alkyl, C(O)N(C1-4alkyl)2, CN, a morpholinyl ring, or an imidazolyl ring, wherein each RB4 alkyl is optionally substituted with up to 3 F atoms, two non-geminal OH groups, or one OC1-2alkyl;
RB5 is hydrogen, C1-4alkyl, C(O)C1-4alkyl, C(O)OC1-4alkyl, C(O)NH2, C(O)NHC1-4alkyl, or C(O)N(C1-4alkyl)2, wherein said RB5 alkyl is optionally substituted with up to 3 F atoms, two non-geminal OH groups, or one OC1-2alkyl and
RB6 is F or C1-2alkyl, or two RB6 and an intervening carbon atom from a spirocyclopropyl or spirocyclobutyl ring.

US Pat. No. 10,391,093

THERAPEUTIC COMPOUNDS

ARIZONA BOARD OF REGENTS,...

1. A method for inhibiting cancer cell growth comprising contacting the cell in vitro or in vivo with an effective amount of a compound of formula II:or a salt thereof wherein:R1 is H, or (C1-C6)alkyl, wherein each (C1-C6)alkyl, that is optionally substituted with one or more groups independently selected from halo;
the bond represented by --- is a single bond or a double bond;
D is

R2 is COOH; and R3 and R4 are each H;wherein the cancer is colon cancer.

US Pat. No. 10,391,082

PROTEIN KINASE INHIBITORS

Orion Corporation, Espoo...

1. A compound of formula (Ia)
wherein
Z is CH;
A is a pyrazolyl ring;
R1 is H;
R2 is C1-7 alkyl;
B is phenyl;
R3 and R4 are halogen;
M is —NHSO2R8;
R8 is C1-7 alkyl or C3-7 cycloalkyl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,391,081

FGFR GATEKEEPER MUTANT GENE AND DRUG TARGETING SAME

Chugai Seiyaku Kabushiki ...

1. A method for treating a subject who has cancer involving activated fibroblast growth factor receptor (FGFR), the method comprising:a) identifying the subject as having a mutant FGFR polypeptide or a polynucleotide encoding the mutant FGFR polypeptide, wherein the mutant FGFR polypeptide comprises either (i) or (ii):
(i) SEQ ID NO: 53 with
(1) a substitution of valine to phenylalanine at position 7, or
(2) a substitution of valine to leucine at position 5, or
(3) both (1) and (2); or
(ii) SEQ ID NO: 54 with
(4) a substitution of valine to phenylalanine at position 7, or
(5) a substitution of valine to leucine at position 5, or
(6) both (4) and (5); and
b) administering to the subject a pharmaceutical composition comprising an active agent that inhibits function of the mutant FGFR polypeptide in an amount effective to treat cancer in the subject, wherein the active agent is a compound of Formula (I) or a pharmaceutically acceptable salt thereof:
wherein R1, R2, R3, and R4 are defined as follows:R1 represents hydrogen, hydroxy, halogen, cyano, nitro, C1-4 haloalkyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-10 aryl C1-4 alkyl, —OR5, —NR6R7, —(CR8R9)nZ1, —C(O)NR12R13, —SR14, —SOR15, —SO2R16, —NR17SO2R18, COOH, C6-10 aryl, a 5- to 10-membered heteroaryl, a 3- to 10-membered heterocyclyl, —COR19, —COOR20, —OC(O)R21, —NR22C(O)R23, —NR24C(S)R25, —C(S)NR26R27, —SO2NR28R29, —OSO2R30, —SO3R31, or —Si(R32)3, wherein the C6-10 aryl is optionally substituted by one or more groups independently selected from group P, and the 5- to 10-membered heteroaryl or the 3- to 10-membered heterocyclyl is optionally substituted by one or more groups independently selected from group Q;
R2 represents hydrogen, hydroxy, halogen, cyano, nitro, C1-4 haloalkyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-10 aryl C1-4 alkyl, —OR5, —NR6R7, —(CR8R9)nZ1, —C(O)NR12R13, —SR14, —SOR15, —SO2R16, —NR17SO2R18, COOH, C6-10 aryl, a 5- to 10-membered heteroaryl, a 3- to 10-membered heterocyclyl, —COR19, —COOR20, —OC(O)R21, —NR22C(O)R23, —NR24C(S)R25, —C(S)NR26R27, —SO2NR28R29, —OSO2R30, —SO3R31, or —Si(R32)3, wherein the C6-10 aryl is optionally substituted by one or more groups independently selected from group P, and the 5- to 10-membered heteroaryl or the 3- to 10-membered heterocyclyl is optionally substituted by one or more groups independently selected from group Q; or
R1 and R2, together with an atom linked thereto, form a 3- to 10-membered heterocyclyl optionally substituted by halogen, or form a 5- to 10-membered heteroaryl optionally substituted by halogen;
R3 represents methyl;
R4 represents hydrogen;
A is indole;
R5 represents C1-5 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-3 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-3 alkoxy C1-4 alkyl, C1-3 alkoxy C1-4 alkoxy C1-4 alkyl, C1-4 aminoalkyl, C1-4 alkylamino C1-4 alkyl, di(C1-4 alkyl)amino C1-4 alkyl, C6-10) aryl, C6-10) aryl C1-3 alkyl, a 3- to 10-membered heterocyclyl C1-3 alkyl, a 3- to 10-membered heterocyclyl, a 5- to 10-membered heteroaryl, a 5- to 10-membered heteroaryl C1-3 alkyl, C1-6 monohydroxy alkyl, C1-6 dihydroxy alkyl, or C1-6 trihydroxy alkyl that is optionally substituted by one or more groups independently selected from group Q;
R6 and R7, which can be the same or different, each represents hydrogen, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-3 alkoxy C1-4 alkyl, C6-10 aryl C1-3 alkyl, a 3- to 10-membered heterocyclyl C1-3 alkyl, a 5- to 10-membered heteroaryl C1-3 alkyl, C1-6 monohydroxy alkyl, C1-6 dihydroxy alkyl, C1-6 trihydroxy alkyl, a 3- to 10-membered heterocyclyl, C1-4 aminoalkyl, C1-4 alkylamino C1-4 alkyl, di(C1-4 alkyl)amino C1-4 alkyl, or cyano(C1-3 alkyl); or alternatively R6 and R7, together with a nitrogen atom linked thereto, form a 3- to 10-membered heterocyclyl or a 5- to 10-membered heteroaryl;
n represents 1 to 3;
R8 and R9, which can be the same or different, each represents hydrogen, C1-4 alkyl, or halogen; or alternatively R8 and R9, together with a carbon atom linked thereto, form a cycloaliphatic ring;
Z1 represents hydrogen, NR10R11, —OH, a 3- to 10-membered heterocyclyl, or a 5- to 10-membered heteroaryl, wherein the 3- to 10-membered heterocyclyl or the 5- to 10-membered heteroaryl is optionally substituted by one or more groups independently selected from group Q;
R10 and R11, which can be the same or different, each represents C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-3 alkoxy C1-4 alkyl, cyano(C1-3 alkyl), or C1-3 alkylsulfonyl C1-4 alkyl; or alternatively R10 and R11, together with a nitrogen atom linked thereto, form a 3- to 10-membered heterocyclyl or a 5- to 10-membered heteroaryl;
R12 and R13, which can be the same or different, each represents hydrogen, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-3 alkoxy C1-4 alkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, a 3- to 10-membered heterocyclyl, C6-10 aryl C1-4 alkyl, a 3- to 10-membered heterocyclyl C1-3 alkyl, a 5- to 10-membered heteroaryl C1-3 alkyl, cyano(C1-3 alkyl), C1-3 alkylsulfonyl C1-4 alkyl, a 3- to 10-membered cycloaliphatic ring, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl; or alternatively R12 and R13, together with a nitrogen atom linked thereto, form a 3- to 10-membered heterocyclyl optionally substituted by one or more groups independently selected from group Q, or form a 5- to 10-membered heteroaryl optionally substituted by one or more groups independently selected from group Q;
R14 represents C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl, wherein the C6-10 aryl is optionally substituted by one or more groups independently selected from group P, and the 5- to 10-membered heteroaryl or the 3- to 10-membered heterocyclyl is optionally substituted by one or more groups independently selected from group Q;
R15 represents C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl, wherein C6-10 aryl is optionally substituted by one or more groups independently selected from group P, and the 5- to 10-membered heteroaryl or the 3- to 10-membered heterocyclyl is optionally substituted by one or more groups independently selected from group Q;
R16 represents C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl, wherein the C6-10 aryl is optionally substituted by one or more groups independently selected from group P, and the 5- to 10-membered heteroaryl or the 3- to 10-membered heterocyclyl is optionally substituted by one or more groups independently selected from group Q;
R17 represents hydrogen or C1-4 alkyl;
R18 represents C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl, wherein C6-10 aryl is optionally substituted by one or more groups independently selected from group P, and the 5- to 10-membered heteroaryl or the 3- to 10-membered heterocyclyl is optionally substituted by one or more groups independently selected from group Q;
R19 represents hydrogen, C1-4 alkyl, C3-7 cycloalkyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl, wherein the 5- to 10-membered heteroaryl or the 3- to 10-membered heterocyclyl is optionally substituted by one or more groups independently selected from group Q;
R20 represents C1-4 alkyl, C3-7 cycloalkyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl;
R21 represents C1-4 alkyl, C3-7 cycloalkyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl;
R22 represents hydrogen, C1-4 alkyl, or C1-4 haloalkyl;
R23 represents hydrogen, C1-4 alkyl, C3-7 cycloalkyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl;
R24 represents hydrogen, C1-4 alkyl, or C1-4 haloalkyl;
R25 represents C1-4 alkyl, C3-7 cycloalkyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl;
R26 and R27, which can be the same or different, each represents hydrogen, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-3 alkoxyl C1-4 alkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, a 3- to 10-membered heterocyclyl, C6-10 aryl C1-4 alkyl, a 3- to 10-membered heterocyclyl C1-3 alkyl, a 5- to 10-membered heteroaryl C1-3 alkyl, cyano(C1-3 alkyl), C1-3 alkylsulfonyl C1-4 alkyl, or a 3- to 10-membered cycloaliphatic ring; or alternatively R26 and R27, together with a nitrogen atom linked thereto, form a 3- to 10-membered heterocyclyl or a 5- to 10-membered heteroaryl;
R28 and R29, which can be the same or different, each represents hydrogen, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-3 alkoxyl C1-4 alkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, a 3- to 10-membered heterocyclyl, C6-10 aryl C1-4 alkyl, a 3- to 10-membered heterocyclyl C1-3 alkyl, a 5- to 10-membered heteroaryl C1-3 alkyl, cyano(C1-3 alkyl), C1-3 alkylsulfonyl C1-4 alkyl, or a 3- to 10-membered cycloaliphatic ring; or alternatively R28 and R29, together with a nitrogen atom linked thereto, form a 3- to 10-membered heterocyclyl or a 5- to 10-membered heteroaryl;
R30 represents C1-4 alkyl, C3-7 cycloalkyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl;
R31 represents C1-4 alkyl, C3-7 cycloalkyl, C1-4 haloalkyl, C6-10 aryl, a 5- to 10-membered heteroaryl, or a 3- to 10-membered heterocyclyl;
R32 represents C1-4 alkyl or C6-10 aryl;
group P consists of: halogen, C1-4 alkyl, C1-4 haloalkyl, —OH, C1-3 alkoxy, C1-3 haloalkoxy, 3- to 10-membered heterocyclylamino, —SO2R16, —CN, —NO2, and 3- to 10-membered heterocyclyl;
group Q consists of: halogen, C1-4 alkyl, C1-4 haloalkyl, —OH, C1-3 alkoxy, C1-6 monohydroxy alkyl, C1-6 dihydroxy alkyl, C1-6 trihydroxy alkyl, 3- to 10-membered heterocyclyl amine, —SO2R16, —CN, —NO2, C3-7 cycloalkyl, —COR19, and 3- to 10-membered heterocyclyl that is optionally substituted by C1-4 alkyl.

US Pat. No. 10,391,075

ANTIVIRAL TREATMENTS

BioCryst Pharmaceuticals,...

1. A method for treating an influenza viral infection in a human comprising administering in a single intravenous administration an effective anti-viral amount of a compound of formula I:
or a pharmaceutically acceptable salt thereof, to the human, wherein the effective anti-viral amount is less than or equal to 600 mg and the influenza viral infection is a type A, type B, H3N2, H1N1, H5N1, avian, or seasonal influenza viral infection.

US Pat. No. 10,391,073

SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TISSUE SELF-REPAIR AND REGENERATION

Prometic Pharma SMT Limit...

1. A method for tissue regeneration of an organ or for stimulating the generation of tissue growth in a subject in need of tissue regeneration, wherein the subject is not in need of a treatment of fibrosis, the method comprising administering to the subject a compound represented by Formula I or a pharmaceutically acceptable salt thereof, or a combination thereof:
wherein
A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4;
R1 is H, F or OH;
R2is H, F OH, C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4;
R3 is H, F, OH or CH2Ph;
R4 is H, F or OH;
Q is
1) (CH2)mC(O)OH wherein m is 1 or 2,
2) CH(CH3)C(O)OH,
3) C(CH3)2C(O)OH,
4) CH(F)—C(O)OH,
5) CF2—C(O)OH, or
6) C(O)—C(O)OH; and
wherein the organ that is regenerated or the tissue that is stimulated to grow is selected from the group consisting of heart, liver, lung, skin, stomach, intestine, muscle or cartilage.

US Pat. No. 10,391,063

PHARMACEUTICAL COMPOSITION OF POLYETHYLENE GLYCOL-MODIFIED CAMPTOTHECIN DERIVATIVE AND PREPARATION METHOD THEREOF

JENKEM TECHNOLOGY CO., LT...

1. A pharmaceutical composition of a polyethylene glycol-modified camptothecin derivative, being a lyophilized preparation prepared by a preparation process with the following components: a polyethylene glycol-modified camptothecin derivative, pH adjuster and water for injection, the pharmaceutical composition comprises 100 to 500 mg of the polyethylene glycol-modified camptothecin derivative, wherein in the preparation process, the pH value of the water for injection comprising the polyethylene glycol-modified camptothecin derivative is adjusted to the range of 3.0 to 4.0 by the pH adjuster, and then a lyophilized preparation is prepared in accordance with a freeze-drying procedure,wherein:
the polyethylene glycol-modified camptothecin derivative has the structure of general formula (I):

wherein:
PEG is a straight-chain polyethylene glycol residue having the structure of general formula (II):

or, PEG is a Y-type polyethylene glycol residue having the structure of general formula (III):

PEG has a molecular weight of 300 to 60,000 Daltons;
wherein I is an integer of 10 to 1,500
A1 is aspartic acid residue

 or glutamic acid residue

 A2 is selected from the group consisting of glycine residue

 alanine residue

 leucine residue

 isoleucine residue

 valine residue

 phenylalanine residue

 and methionine residue

m is an integer of 2 to 12;
n is an integer of 0 to 6;
and CPT is a camptothecin derivative residue selected from the group consisting of: 10-hydroxycamptothecin residue

 7-ethyl-10-hydroxycamptothecin residue

 9-nitrocamptothecin residue

 9-aminocamptothecin residue

 irinotecan residue

 topotecan residue

 belotecan residue

 exatecan residue

 lurtotecan residue

 diflomotecan residue

 gimatecan residue

 and karenitecin residue

US Pat. No. 10,391,061

DELAYED RELEASE PHARMACEUTICAL FORMULATION AND METHODS OF MAKING AND USING SAME

Tillotts Pharma AG, Rhei...

1. A delayed release pharmaceutical formulation for delivering an active agent to the intestine, wherein said formulation comprises carrier particles and at least one active agent associated with the carrier particles, further wherein the carrier particles are porous particles that are surrounded by a material for colon targeting, further wherein the carrier particles comprise functionalized calcium carbonate, further wherein (a) the material for colon targeting comprises a compound which is susceptible to attack by colonic bacteria, and/or (b) the carrier particles are at least partially coated with either or both of a mucoadhesive compound and a sustained release coating.

US Pat. No. 10,391,042

TREATMENT COMPOSITIONS, APPARATUS AND METHODS FOR MODIFYING KERATINOUS SURFACES

1. A stable, particulate containing, printer composition comprising:a. one or more particulate suspending agents in a concentration of from about 0.05% to about 5%, by weight, wherein the particulate suspending agent is a polyacrylate or polyacrylate derivative with a counter ion selected from the group consisting of sodium, potassium, ammonium, and mixtures thereof;
b. one or more particulate compositions, wherein the particles in the particulate composition have a combined Particle Size Distribution D50 in the range of about 200 ?m to about 500 ?m; and
c. water;
wherein the one or more particulate compositions has a zeta potential of negative 20 or less, or greater than positive 20;
wherein the printer composition has a viscosity of less than 10 cP and
wherein the printer composition can be ejected from a thermal inkjet or piezo inkjet printing system.

US Pat. No. 10,391,035

MEDICATION SYSTEM WITH A MEDICATION TRAY AND METHOD FOR CREATING A DELIVERY-READY MEDICATION SYSTEM

MEDINOXX GMBH, Inssbruck...

1. A medication system comprises:a medication tray having:
a rectangular tray sheet with a number of individual receiving sites, which are separated from each other and run in rows, and
a plurality of containers containing liquid or solid medicines, which are positioned in the receiving sites such that they are individually removable, each container of the plurality of containers has an upper edge with a level surface extending from a contoured outer edge to an upper opening in the level surface,
a plurality of plastic films welded on the plurality of containers, each container of the plurality of containers having a plastic film of the plurality of plastic films sealed to only the level surface of the upper edge to cover the upper opening, each plastic film of the plurality of plastic films having a film edge defined by a perforation along the contoured outer edge of the container welded thereto,
wherein:
the rectangular tray sheet is a re-usable plastic injection moulded part, and
each plastic film of the plurality of plastic films originates from a single flexible plastic film provided with a plurality of perforations along the contoured outer edges of the plurality of containers to define the film edge of each of the plurality of plastic films and a film mesh between the plurality of perforations, wherein the medication tray is devoid of the film mesh, which is removed from the plurality of plastic films at the plurality of perforations.

US Pat. No. 10,391,034

MULTIPLE-FLUID INJECTION PUMP

R.P. SCHERER TECHNOLOGIES...

1. A pump (100) for dispensing predetermined volumes of at least a first fluid (11A) and a second fluid (11B), the pump comprising:one or more first syringe units (55A), each first syringe unit (55A) comprising a first plunger (50A) and a first chamber (80A) within which the first plunger (50A) slides;
a first inlet channel (10A) fluidly connected to the first chamber (80A) of each first syringe unit (55A) and configured to receive the first fluid (11A);
one or more first discharge ports (20A) located in the first syringe unit (55A) at a location different from a location of the first inlet channel (10A) in the first syringe unit (55A), each first discharge port (20A) fluidly connected to the first chamber (80A) of a corresponding first syringe unit (55A), wherein each first syringe unit (55A) is operable to receive the first fluid (11A) via the first inlet channel (10A) and dispense a corresponding first predetermined volume of the first fluid (11A) via the corresponding first discharge port (20A) with every cycle of the corresponding first plunger (50A) sliding within the corresponding first chamber (80A);
one or more second syringe units (55B), each second syringe unit (55B) comprising a second plunger (50B) and a second chamber (80B) within which the second plunger (50B) slides;
a second inlet channel (10B) fluidly connected to the second chamber (80B) of each second syringe unit (55B) and configured to receive the second fluid (11B);
one or more second discharge ports (20B) located in the second syringe unit (55B) at a location different from a location of the second inlet channel (10B) in the second syringe unit (55B), each second discharge port (20B) fluidly connected to the second chamber (80B) of a corresponding second syringe unit (55B), wherein each second syringe unit (55B) is operable to receive the second fluid (11B) via the second inlet channel (10B) and dispense a corresponding second predetermined volume of the second fluid (11B) via the corresponding second discharge port (20B) with every cycle of the corresponding second plunger (50B) sliding within the corresponding second chamber (80B), such that:
the one or more first syringe units (55A) and the one or more second syringe units (55B) are configured to be operated by a single actuator in parallel such that when the first plunger (50A) moves to cause the first fluid (11A) to fill the first chamber (80A) the second plunger (50B) moves to cause the second fluid (11B) to discharge from the second chamber (80B), and
when the second plunger (50B) moves to cause the second fluid (11B) to fill the second chamber (80B) the first plunger (50A) moves to cause the first fluid (11A) to discharge from the first chamber (80A),
the one or more first discharge ports (20A) and the one or more second discharge ports (20B) fluidly configured to deliver the first and second fluids (11A, 11B) to one or more common locations, whereby each common location receives both the first predetermined volume of the first fluid (11A) and the second predetermined volume of the second fluid (11B).

US Pat. No. 10,391,032

STERILIZABLE FLEXIBLE PACKAGE FOR THE RECONSTITUTION AND ADMINISTRATION OF FLUID MEDICINAL OR NUTRITIONAL SUBSTANCES WHICH ARE INFUSED OR INSTILLABLE WITHIN THE BODY OF A PATIENT

PAOLO GOBBI FRATTINI S.R....

1. A package for reconstitution and administration of fluid medicinal or nutritional substances which are infused or instillable within the body of a patient, comprising a flexible casing containing a vial with closing cap for medicinal or nutritional substance, which vial is in coupling position with a coupling and perforation device inserted into a mixing tube for the connection with a bag of liquid diluent, wherein said coupling, and perforation device comprises a first element slidably coupled with a second element and movable between a vial coupling position and a vial cap perforating position, wherein said first element comprises a ring from which at least two flaps vertically extend which are provided with notches suitable to receive the vial in engagement position, and an operable closure surmounted by a circular base from the perimeter of which further adjacent flaps vertically extend, which are equipped with notches suitable to accommodate the vial in the vial cap perforating position, and said ring is inserted outside said additional flaps and is configured to slide coaxially with respect to the circular base, and said further flaps have a curvature at their free ends such as to constitute a first limit for said first element with respect to the vial in the vial coupling position, and said notches are configured to contrast with said circular base and form a second limit for said first element with respect to the vial in the vial cap perforating position, wherein said flexible casing further comprises a connector provided with an openable and hermetically reclosable cap, suitable for the introduction of a mixture of sterilizing gas and oxygen within said casing.

US Pat. No. 10,391,006

POWERED ROLL-IN COTS HAVING WHEEL ALIGNMENT MECHANISMS

Ferno-Washington, Inc., ...

1. A roll-in cot comprising:a support frame comprising a front end and a back end;
a front pair of legs at least one of pivotably coupled and slidingly coupled to the support frame;
a front hinge member pivotably coupled to the support frame and to one of the front pair of legs;
a front wheel linkage pivotably coupled to the front pair of legs;
a rear pair of legs at least one of pivotably coupled and slidingly coupled to the support frame;
a rear hinge member pivotably coupled to the support frame and to one of the rear pair of legs;
a rear wheel linkage pivotably coupled to the rear pair of legs; and
a wheel alignment mechanism incorporated into at least one of the front or rear pairs of legs, wherein:
the front pair of legs and the rear pair of legs are pivotable relative to the support frame and independently of one another;
the front pair of legs and the front pair of hinge members pivot relative to one another in a relative angular rotation ratio;
the rear pair of legs and the rear pair of hinge members pivot relative to one another in a relative angular rotation ratio;
the wheel alignment mechanism rotates at least one of the respective wheel linkages relative to the respective pair of legs at a reduction ratio, the wheel alignment mechanism comprising:
a first hub held forming a pivot point about a location where the corresponding front or rear hinge member is coupled to the respective pair of legs through a fixed position relative to the corresponding front or rear hinge member and a rotatable position relative to the respective pair of legs;
a second hub forming a pivot point about a location where the corresponding front or rear wheel linkage is coupled to the respective pair of legs through a fixed position relative to the corresponding front or rear wheel linkage and a rotatable position relative to the respective pair of legs; and
a timing mechanism rotationally coupled to and extending between the first and second hubs and rigidly coupled to at least one of the first and second hubs along at least a portion of an outer periphery of the corresponding first or second hub through at least one attachment plate such that upon raising or lowering of the respective pair of legs, the timing mechanism transmits relative rotational movement between the respective pair of legs and corresponding front or rear hinge member into a corresponding rotation of the respective wheel linkage in proportion to relative diameter differences of the first and second hubs in order to maintain a relative angular inclination of the respective wheel linkage to a ground surface.

US Pat. No. 10,390,985

BARIATRIC CLAMP WITH SUTURE PORTIONS, MAGNETIC INSERTS AND CURVATURE

ADVANCED BARIATRIC TECHNO...

1. A bariatric clamp comprising:a first elongated portion having a first proximal end and a first distal end opposite the first proximal end and comprising a first substrate member and a first polymer portion at least partially surrounding the first substrate member;
a second elongated portion having a second proximal end and a second distal end opposite the second proximal end and comprising a second substrate member and a second polymer portion at least partially surrounding the second substrate member; and
a bight portion comprising a third polymer portion forming a flexible hinge joining the first elongated portion at the first proximal end thereof and joining the second elongated portion at the second proximal end thereof;
wherein at least a portion of at least one of the first elongated portion and the second elongated portion is bent at least one of toward and away from the other of the first elongated portion and the second elongated portion at an intermediate point between the respective proximal end and the respective distal end of the elongated portion that is bent, and
wherein the intermediate point is nearer the other of the first elongated portion and the second elongated portion than at least one of the proximal end of the elongated portion that is bent and the distal end of the elongated portion that is bent is.

US Pat. No. 10,390,935

SOFT TISSUE TO BONE REPAIR DEVICES, SYSTEMS, AND METHODS

CoNextions, Inc., Salt L...

1. A repair device system for fixating soft tissue to bone, the soft tissue extending longitudinally to define an axis thereof, comprising:a carrier member extending with a seamless, monolithic structure, the carrier member including multiple pad portions and a bone coupling portion, the carrier member defining a longitudinal axis such that the longitudinal axis of the carrier member is configured to extend along the axis of the soft tissue, each of the pad portions being aligned with an adjacent pad portion and each of the pad portions having at least two openings defined therein, the pad portions configured to be positioned over a side of the soft tissue, each of the multiple pad portions coupled to the adjacent pad portion with first struts and second struts, the first struts extending transversely relative to the longitudinal axis and the second struts extending longitudinally along and substantially parallel with the longitudinal axis, the first struts each extending with a first elongated structure and the second struts each extending with a second elongated structure, each first elongated structure extending longitudinally at an acute angle from, and continues in a direction alongside, one of the second elongated structures to one of the pad portions such that each of the first elongated structures longitudinally extends in a common plane as the one of the second elongated structures, the first strut moveable to facilitate movement of at least one of the pad portions relative to the longitudinal axis of the carrier member, the bone coupling portion including an elongated portion extending co-axially from one of the second struts; and
multiple anchors, each anchor being a separate and discrete structure relative to the carrier member, and each of the anchors sized and configured to be coupled to the carrier member so as to extend through the at least two openings of one of the multiple pad portions and so as to extend directly from one of the multiple pad portions and through the soft tissue to fixate the carrier member to the soft tissue.

US Pat. No. 10,390,934

MEDICAL DEVICE

Merlin MD Pte. Ltd., Sin...

1. A medical device for treating a bifurcation or trifurcation aneurysm, in a patient, occurring at a first artery, the first artery and a second artery joining to a third artery, the device comprising:an expandable latticework frame having first and second struts that each define a radially outermost edge, a radially innermost edge, a circumferential strut width, and a wall thickness between the radially outermost and innermost edges; and
a porous membrane that extends around and between the first and second struts, the membrane having a web portion that, between the first and second struts, extends only within a central region being (i) bounded radially between the radially outermost edges and the radially innermost edges of the first and second struts and (ii) bounded circumferentially between the first and second struts, the web portion defining a web thickness that is less than the wall thickness of the first or second struts,
wherein the porous membrane includes a first layer attached to the outer surface of the expandable latticework frame, an intermediate layer attached to the first layer, and a second layer covering the first layer and the intermediate layer, and
wherein the membrane is configured to (i) reduce blood supply into the aneurysm, and (ii) permit blood supply through pores of the membrane and into perforators and/or microscopic branches of the first artery so as not to inhibit blood supply functions of the perforators and/or microscopic branches.

US Pat. No. 10,390,933

DEVICES FOR FLUID FLOW THROUGH BODY VESSELS

LimFlow GmbH, Dresden (D...

1. A device for supplying fluid flow in a human or animal body, the device comprising:a first end portion configured to anchor the device in a first vessel;
a second end portion configured to anchor the device in a second vessel different than the first vessel, wherein the first end portion and the second end portion are diametrically expandable to anchor the device in the first vessel and the second vessel;
an intermediate portion located between the first end portion and the second end portion, the intermediate portion configured to permit movement of the first end portion and the second end portion relative to each another, the intermediate portion being diametrically expandable to dilate at least the intermediate portion;
a fluid pathway at least partially defined by the first end portion, the second end portion, and the intermediate portion;
a support structure comprising a mesh extending between the first end portion and the second end portion; and
a polymer tube at least partially defining a lumen, the lumen comprising at least a portion of the fluid flow pathway,
wherein the first end portion, the second end portion, and the intermediate portion are self-expanding, and
wherein the intermediate portion is configured to be expanded by a balloon after self-expanding.

US Pat. No. 10,390,926

ASPIRATION DEVICES AND METHODS

Insera Therapeutics, Inc....

1. A system for aspirating thrombi using an operator-selectable suction pattern, the system comprising:an external control panel that allows an operator to choose from any of a plurality of stored crescendo suction patterns during a thrombus aspiration procedure,
wherein each of the plurality of stored crescendo suction patterns comprises a repetitive cycle pattern having at least two different suction intensity levels,
wherein the at least two different suction intensity levels are selected from one of three suction intensity levels,
wherein a first suction intensity level is within a range between ?100 and ?350 mm Hg, wherein a second suction intensity level is within a range between ?351 and ?550 mm Hg, and wherein a third suction intensity level is within a range between ?551 and ?769 mm Hg,
wherein a first suction pattern of the plurality of stored crescendo suction patterns is configured for aspiration of soft clots,
wherein a second suction pattern of the plurality of stored crescendo suction patterns is configured for aspiration of hard clots; and
a vacuum pump comprising power electronics that generate the plurality of stored crescendo suction patterns.

US Pat. No. 10,390,924

SYSTEM AND METHOD FOR PELVIC FLOOR REPAIR

POP MEDICAL SOLUTIONS LTD...

1. A system for attaching an anchor to a ligament located outside of a tissue wall, the system comprising:a body-insertable mounting having a longitudinal axis;
a working channel extending at an angle with respect to said longitudinal axis, mounted onto said body-insertable mounting; and
a suture and penetrating anchor assembly which is configured to be axially displaceable along said working channel through said tissue wall and into anchoring relationship with said ligament,
said suture and penetrating anchor assembly including a proximity sensor at a distal end thereof.

US Pat. No. 10,390,919

INSPECTION APPARATUS FOR OSSEOINTEGRATION OF IMPLANTS

National Central Universi...

1. An inspection apparatus for osseointegration of implants, comprising:an inspection base;
a holding end, disposed at one end of said inspection base, further including a signal processing module and a wireless transmission module disposed inside of said holding end, and said signal processing module connected electrically with said wireless transmission module; and
an inspection end, disposed at the other end of said inspection base and on one side of said holding end, further including an inspection probe disposed at one of said inspection end, one end of said inspection probe including one or more excitation device and a receiver, said one or more excitation device and said receiver located on the same side of said inspection probe, and said excitation device and said receiver connected electrically with said signal processing module;
where said inspection apparatus approaches an object under inspection; said signal processing module enables said excitation device to generate an excitation source to vibrate said object under inspection in a non-contact manner; meanwhile, said receiver receives the vibration response signal of said object under inspection; said signal processing module analyzes said vibration response signal and gives a displacement difference; and said wireless transmission module transmits said displacement difference to an electronic apparatus.

US Pat. No. 10,390,913

DIAGNOSTIC INTRAORAL SCANNING

Align Technology, Inc., ...

1. A method comprising:displaying a three-dimensional (3D) model of a patient's dental arch;
displaying a viewing window over at least a portion of the 3D model of the patient's dental arch;
receiving, from a user, a change in a relative position between the viewing window and the 3D model of the patient's dental arch;
identifying, from both the 3D model of the patient's dental arch and a plurality of images of a patient's dental arch taken from different angles and positions relative to the patient's dental arch, a near-infrared (near-IR) image taken at an angle and position that approximates a relative angle and position between the viewing window relative to the 3D model of the patient's dental arch; and
displaying the identified near-IR image taken at the angle and position that approximates the angle and position between the viewing window relative to the 3D model of the patient's dental arch.

US Pat. No. 10,390,897

MEDICAL DEVICE ADAPTER WITH WRIST MECHANISM

Covidien LP, Mansfield, ...

1. A surgical device having a drive mechanism comprising:a proximal transmission shaft defining a first longitudinal axis, the proximal transmission shaft including a connector sleeve disposed at a proximal end thereof and a first gear disposed at a distal end thereof, wherein the connector sleeve is couplable to the surgical device;
a middle transmission shaft including a second gear disposed at a proximal end thereof and meshingly engaged with the first gear and a third gear disposed at a distal end thereof, the middle transmission shaft defining a second longitudinal axis, the middle transmission shaft movable relative to the proximal transmission shaft from a first position where the first and second longitudinal axes are in a parallel orientation to a second position where the first and second longitudinal axes are in a non-parallel orientation; and
a distal transmission shaft including a fourth gear disposed at a proximal end thereof and meshingly engaged with the third gear, the distal transmission shaft defining a third longitudinal axis, the distal transmission shaft movable relative to the proximal and middle transmission shafts,
wherein the first, second, third and fourth gears define an elliptical shape along each respective axis of the first, second, and third longitudinal axes, the first, second, third, and fourth gears maintaining rotatable engagement during a respective movement of the proximal, middle, and distal transmission shafts.

US Pat. No. 10,390,881

COOLED MICROWAVE DENERVATION CATHETER WITH INSERTION FEATURE

Denervx LLC, Maple Grove...

1. A catheter configured to be inserted into a body lumen to create a lesion in tissue spaced from the body lumen while protecting tissue forming and adjacent to a wall of the body lumen from injury, the catheter comprising:a catheter body having at least one fluid passage therein;
a balloon in communication with the at least one fluid passage to receive cooling fluid for inflating the balloon into a shape that surrounds the catheter body and contacts the wall of the body lumen when the catheter is positioned in the body lumen, the cooling fluid having a temperature that is less than basal body temperature;
a microwave antenna carried by the catheter so as to be surrounded by the balloon in the inflated shape of the balloon, the microwave antenna being connectable to a microwave generator to supply power to the microwave antenna to cause microwave energy to be emitted omnidirectionally from the microwave antenna, thereby heating the tissue spaced from the body lumen to a temperature sufficient to cause thermal damage while the tissue forming and adjacent to the wall of the body lumen are maintained at a temperature where thermal damage does not occur by virtue of circulation of cooling fluid in the balloon around the microwave antenna; and
a tip structure located at an end of the catheter body adjacent to and extending distally further than the microwave antenna, the tip structure being configured to receive a guide wire extending through the at least one fluid passage in the catheter body while sealing the at least one fluid passage in the catheter body from leakage.

US Pat. No. 10,390,875

SYSTEM AND APPARATUS FOR AUTOMATIC ACTIVATION USING RADIO FREQUENCY SENSOR

I.C. Medical, Inc., Phoe...

1. A system for automatic smoke evacuation comprising:a surgical instrument capable of producing a radiofrequency during its operation;
a smoke evacuation unit capable of evacuating at least one of smoke and debris through a smoke evacuation channel;
a wireless radiofrequency sensor and transmitter device that is both separate from and not connected to the smoke evacuation unit and separate from and not contained within the surgical instrument, wherein the wireless radiofrequency sensor and transmitter device is capable of receiving a transmitter device signal from the surgical instrument and transmitting a signal;
a radiofrequency receiver connected to, or incorporated within, the smoke evacuation unit that is capable of receiving the transmitter device signal transmitted from the wireless radiofrequency sensor and transmitter device,
wherein the wireless radiofrequency sensor and transmitter device comprises a plurality of radiofrequency sensor components and a plurality of radiofrequency transmitter components, and
wherein the plurality of radiofrequency sensor components includes a single transistor, a double transistor, and an optocoupler wherein the single transistor and the double transistor are in sequence with one another and the optocoupler is in sequence with the double transistor.

US Pat. No. 10,390,868

FLUID DISPLACEMENT AND PRESSURIZING DEVICES, AND ASSEMBLY THEREOF

ATRION MEDICAL PRODUCTS, ...

1. A fluid displacement and pressurizing device comprising: a housing having a longitudinal axis; and a carrier member which is disposed generally in the housing, and which is removable from the housing; a plunger which extends through the carrier member; a plunger engaging structure pinned to, and moveable relative to, the carrier member, wherein the plunger engaging structure is selectively engageable with, and disengageable from, the plunger, wherein the housing and the carrier member are configured such that the carrier member and the plunger engaging structure are transversely installable in the housing relative to the longitudinal axis of the housing after the plunger engaging structure has been pinned to the carrier member.

US Pat. No. 10,390,867

BONE PLATE SYSTEM AND METHOD

Biomet C.V., Warsaw, IN ...

1. A bone plate system internally fixating a fractured bone of a patient, the system comprising:a bone plate including a head portion and a shaft portion having a longitudinal axis, the head portion being wider than the shaft portion, the bone plate further including:
a plurality of threaded, locking bone fastener apertures defined in the shaft portion and defining a respective plurality of threaded aperture axes; and
a plurality of non-threaded, non-locking bone fastener apertures defined in the shaft portion, aligned on the longitudinal axis, and defining a respective plurality of non-threaded aperture axes,
each non-threaded aperture axis being angled between about ten degrees and about thirty degrees with respect to each threaded aperture axis,
each of the plurality of non-threaded bone fastener apertures being paired together with at least one of the plurality of the threaded bone fastener apertures to form a plurality of discrete aperture clusters,
a first aperture cluster of the plurality of discrete aperture clusters being positioned about a proximal end of the shaft portion,
a second aperture cluster of the plurality of discrete aperture clusters being positioned about a distal end of the shaft portion,
the first and second aperture clusters including respective threaded, locking bone fastener apertures that are positioned on laterally opposed sides of the longitudinal axis; and
a plurality of bone fasteners,
each of the plurality of bone fasteners comprising a shaft and a head,
each head being dimensioned and configured to threadedly engage each of the plurality of threaded, locking bone fastener apertures to provide a fixed angle locking construct,
each head also being dimensioned and configured to directly engage each of the plurality of non-threaded, non-locking bone fastener apertures to provide a polyaxial compressive construct.

US Pat. No. 10,390,861

SPINAL STABILIZATION DEVICE, SYSTEM, AND METHOD OF USE

K2M, Inc., Leesburg, VA ...

1. A spinal stabilization device comprising:a rod receiving member defining a first throughhole, a collet recess aligned with the first throughhole, and a rod receiving slot offset from the first throughhole;
a collet insertable into the collet recess of the rod receiving member, the collet defining an aperture, a plug recess aligned with the aperture, and a wall portion, the wall portion and the rod receiving slot cooperatively defining a rod securement region configured to selectively fix a spinal rod therein, the collet transitionable between a first diameter, wherein the rod securement region defines a first diameter, and a second, larger diameter, wherein the rod securement region defines a second, smaller diameter;
a plug insertable within the plug recess of the collet and configured to transition the collet between the first and second diameters, such that the collet is in the first diameter when the plug is removed and the collet is in the second diameter when the plug is inserted; and
a first bone screw including a head portion and a threaded portion, the threaded portion insertable through the first throughhole of the rod receiving member and the aperture of the collet.

US Pat. No. 10,390,835

SURGICAL FASTENER APPARATUS WITH LINEAR POSITION SENSOR

Covidien LP, Mansfield, ...

1. A fastener apparatus, which comprises:a handle;
an elongate body connected to the handle, the elongate body defining a longitudinal axis and having proximal and distal ends;
a fastener cartridge disposed adjacent the distal end of the elongate body, the fastener cartridge having at least one fastener;
a pusher at least partially disposed within the elongate body, the pusher adapted for longitudinal movement through a firing stroke to eject the at least one fastener from the fastener cartridge;
a linear position sensor mounted within the elongate body and dimensioned and positioned to engage the pusher during movement through the firing stroke, the linear position sensor including a sensor mount, and a spring supported in cantilevered fashion in relation to the sensor mount and positioned to be engaged by the pusher, the linear position sensor adapted to send at least one output signal representative of strain imparted thereupon by the pusher during the firing stroke; and
a controller configured and adapted to determine a position of the pusher within the firing stroke based upon the at least one output signal.

US Pat. No. 10,390,831

ENDOSCOPIC REPOSABLE SURGICAL CLIP APPLIER

Covidien LP, Mansfield, ...

1. A reposable surgical clip applier, comprising:a handle assembly including:
a housing defining a bore therein and which extends through a distal end thereof;
a fixed handle extending from the housing;
a trigger pivotally connected to the fixed handle, the trigger including an actuating end disposed within the bore of the housing;
a drive plunger slidably supported within the bore of the housing and axially aligned with the bore of the housing, the drive plunger having a proximal end operatively engaged by the actuating end of the trigger, and a free distal end; and
a release lever supported on the housing, wherein the release lever includes a catch for engaging and securing an endoscopic assembly that is selectively connected to the handle assembly; and
a first endoscopic assembly selectively connectable to the housing of the handle assembly, via the catch of the release lever, the first endoscopic assembly including:
a shaft assembly having:
an outer tube defining a lumen therethrough, the outer tube including a proximal end and a distal end;
a pair of jaws pivotably and fixedly supported in, and extending from the distal end of the outer tube; and
an inner shaft slidably supported within the lumen of the outer tube, the inner shaft including a proximal end and a distal end, the distal end of the inner shaft being operatively engaged with the pair of jaws to effectuate an opening and a closing of the pair of jaws upon an axial translation of the inner shaft relative to the outer tube; and
a hub assembly configured for selective insertion in the bore of the housing of the handle assembly, the hub assembly including:
an outer housing supported on the proximal end of the outer tube, the outer housing defining an open proximal end; and
a drive assembly supported within the outer housing of the hub assembly, the drive assembly including:
a cartridge cylinder slidably supported in the outer housing of the hub assembly, the cartridge cylinder including a proximal end wall, an open distal end, and a bore therein;
a cartridge plunger supported on the proximal end of the inner shaft of the shaft assembly, the cartridge plunger being slidably supported in the bore of the cartridge cylinder;
a first biasing member disposed within the bore of the cartridge cylinder, and being interposed between the proximal end wall of the cartridge cylinder and the cartridge plunger; and
a second biasing member interposed between a proximal end of the outer tube of the shaft assembly and the cartridge plunger.

US Pat. No. 10,390,826

SURGICAL STAPLING DEVICE WITH ELONGATED TOOL ASSEMBLY AND METHODS OF USE

Covidien LP, Mansfield, ...

1. A surgical stapling device comprising:an actuator including a housing defining a handle assembly;
an adaptor assembly having a proximal portion releasably secured to the actuator and a distal portion; and
a tool assembly supported on the distal portion of the adaptor assembly, the tool assembly including a first jaw and a second jaw, the first jaw being movable in relation to the second jaw from an unclamped position to a clamped position, the first jaw being secured to the second jaw by distal and proximal approximation shafts, wherein in the unclamped position, the distal approximation shaft is secured to a distal portion of the first jaw and a distal portion of the second jaw to secure the distal portion of the first jaw of the tool assembly to the distal portion of second jaw of the tool assembly, and the proximal approximation shaft is secured to a proximal portion of the first jaw and a proximal portion of the second jaw to secure the proximal portion of the first jaw to the proximal portion of the second jaw.

US Pat. No. 10,390,823

END EFFECTOR COMPRISING AN ADJUNCT

Ethicon LLC, Guaynabo, P...

1. An end effector, comprising:a staple cartridge, comprising:
a cartridge body, comprising:
a deck;
a cartridge longitudinal slot configured to receive a cutting member;
a first set of staple cavities defined in said deck; and
a second set of staple cavities defined in said deck, wherein said first set is different than said second set, and wherein said first set of staple cavities is positioned adjacent to said cartridge longitudinal slot;
a plurality of staples removably stored within said cartridge body, wherein said staples are ejectable from said cartridge body during a staple firing stroke;
longitudinal rows of staple drivers, wherein each said longitudinal row of staple drivers comprises a proximal end and a distal end, wherein said staple drivers are positioned at different heights relative to said deck prior to said staple firing stroke, and wherein said staple drivers are liftable toward said deck to sequentially deform said staples to different formed heights; and
an implantable layer assembly releasably attached to said cartridge body, comprising:
a first layer positioned over said first set of staple cavities; and
a second layer positioned over said second set of staple cavities,
wherein said first layer partially overlaps said second layer, and wherein said first layer covers more of said deck than said second layer; and
an anvil, comprising:
a plurality of staple-forming pockets comprising a first set of staple-forming pockets and a second set of staple-forming pockets; and
an anvil longitudinal slot comprising a T-shaped opening configured to receive said cutting member, wherein said T-shaped opening extends behind said first set of staple-forming pockets.

US Pat. No. 10,390,817

TISSUE FIXATION SYSTEM AND METHOD

P Tech, LLC, Effingham, ...

1. A system for securing body tissue, comprising:an elongate member, wherein the elongate member is configured to secure at least one of a tissue, bone, and implant; and
a medical device configured to tension the elongate member, the medical device comprised of:
a handle;
an outer tube, fixed in position relative to the handle, including first and second ends and defining a longitudinal passage along a central longitudinal axis, wherein the second end of the outer tube is disposed in the handle, and wherein the elongate member is configured to enter the first end of the longitudinal passage of the outer tube, and pass at least partially through the longitudinal passage in the outer tube; and
a tensioning mechanism disposed on the handle of the medical device, the tensioning mechanism comprising:
a rotation assembly;
at least one biasing member configured to apply a tension force to the elongate member; and
a rotatable shaft positioned along an axis perpendicular to and intersecting the axis defined by the longitudinal passage of the outer tube, the rotatable shaft having an open end slotted aperture through which the elongate member is configured to be captured and secured,
wherein rotational actuation of the rotation assembly of the tensioning mechanism applies tension to the elongate member as the rotation assembly wraps the elongate member around the rotatable shaft.

US Pat. No. 10,390,765

DECISION SUPPORT SYSTEM FOR ANTICIPATING A MYOCARDIAL ISCHEMIC EVENT

Cerner Innovation, Inc., ...

1. Computer-readable media having computer-executable instructions embodied thereon that when executed by one or more processors, provide a method for anticipating myocardial ischemia, the method comprising:acquiring, using one or more patient monitors, a plurality of measurements of vital signs for the a patient, the vital sign measurements acquired over a timespan;
constructing, via the one or more computer processors, a vital signs time series from the acquired measurements;
determining, via a the one or more computer processors, a linear model and cusp catastrophe model based on the vital signs time series;
calculating, via the one or more computer processors, a goodness-of-fit measure for the linear model and cusp model;
determining, via the one or more computer processors, a likelihood of the patient experiencing a myocardial ischemia occurrence over a future timeframe by determining that the cusp model transgresses a first threshold or exceeds a second threshold for a ratio of linear-to-cusp model; and
based on the determined likelihood, initiating a response action to avoid patient mortality.

US Pat. No. 10,390,763

METHOD, SYSTEM, NON-TRANSITORY COMPUTER-READABLE MEDIUM AND COMPUTER PROGRAM PRODUCT FOR CALIBRATING TIME OF PHYSIOLOGICAL DATA

TAIDOC TECHNOLOGY CORPORA...

1. A method for calibrating time of a physiological data, which is adapted to a physiological monitoring device for measuring at least one physiological parameter, comprising:providing the physiological monitoring device comprising a memory for storing a physiological data with a first measurement time, and the physiological monitoring device having a first counting time;
establishing a wireless communication channel between the physiological monitoring device and a time calibration device having a second counting time;
comparing the first counting time and the second counting time to obtain a counting time deviation value;
comparing the counting time deviation value with a predetermined time deviation value;
calibrating the first measurement time of the physiological data, wherein when the counting time deviation value exceeds the predetermined time deviation value, the first measurement time and the counting time deviation value are computed to obtain a calibrated measurement time of the physiological data; and
comparing the counting time deviation value and a second predetermined time deviation value, wherein the first counting time is calibrated to the second counting time when the counting time deviation value exceeds the second predetermined time deviation value.

US Pat. No. 10,390,751

FEEDBACK DEVICE FOR REDUCTION OF FOOT SKIN DAMAGE IN PATIENTS WITH SENSORY LOSS

RxFunction, Inc., Eden P...

1. A system for reducing foot skin damage caused by sustained elevated pressures, the system comprising:a) at least one sensor positionable under a foot of a user, wherein the at least one sensor is positioned to sense an amount of force applied to the at least one sensor, wherein the at least one sensor is configured to generate, during user stance and dynamic activities, user foot pressure information signals and transmit the pressure information signals;
b) a signal processing subsystem, the subsystem configured to receive the user foot pressure information signals, compare the user foot pressure information signals to a predetermined temporal force threshold, and generate user foot pressure control signals comprising temporal information reflecting an amount of force applied to the at least one sensor; and
c) at least one stimulator configured to be responsive to the user foot pressure control signals to provide stimulation based on the user foot pressure control signals, thereby providing feedback to the user to allow corrective action to reduce or eliminate skin damage.

US Pat. No. 10,390,746

CATHETER

PLAQUETEC LIMITED, Londo...

16. A catheter system comprising:(A) a catheter device for insertion into a blood vessel, the catheter device being flexible so as to be channeled through the blood vessel, and having a blunt distal end, comprising:
a sampling part arranged to collect and preserve a plurality of spatially separated discrete blood samples from a plurality of locations along a length of the blood vessel;
wherein the sampling part includes:
an axially elongated sample member having an axial array of a plurality of openings for receiving blood from outside of the catheter device at intervals along the length of the blood vessel; and,
an elongated sleeve coaxial with the sample member, the sleeve defining an axial passage for housing the sample member and including a plurality of through holes corresponding to said openings in the sample member, and
wherein movement between the sleeve and the sample member aligns all the through holes with the openings of the sample member, to simultaneously expose all the openings to blood outside the catheter device so as to collect the plurality of discrete blood samples along the length of the blood vessel; and
(B) an apparatus for analyzing discrete blood samples captured by the catheter device, the apparatus being capable of analyzing blood samples taken from the plurality of locations along said length of the blood vessel by providing a profile of concentration levels for one or more pathological markers in the samples taken along said length of the blood vessel.

US Pat. No. 10,390,719

PATCH-TYPE ADHESIVE SENSOR

SHINKO ELECTRIC INDUSTRIE...

1. A patch-type module comprising:a substrate provided with one surface and another surface that is opposite to the one surface, the other surface being a sticky surface, the substrate having a hole formed therethrough;
an air cell mounted to the substrate;
a seal that blocks air from entering the air cell, the seal having a first surface that is attached to a surface of the air cell;
an electronic component mounted on the substrate and configured to be operated by power supplied from the air cell;
an adhesion layer provided to cover the sticky surface of the substrate and a second surface of the seal that is opposite to the first surface; and
a protection sheet that is attached to the sticky surface of the substrate through the adhesion layer, and attached to the second surface of the seal through the adhesion layer,
wherein the air cell is disposed in the hole of the substrate such that the surface of the air cell is flush with the sticky surface, and the first surface of the seal is attached to both the surface of the air cell and to the sticky surface while the second surface of the seal is attached to the protection sheet through the adhesion layer,
wherein the adhesion strength between the adhesion layer and the protection sheet is greater than the adhesion strength between the adhesion layer and the sticky surface of the substrate, and
wherein when the protection sheet is peeled, the adhesion layer and the seal are peeled together to expose the sticky surface of the substrate and start introduction of air inside the air cell so that electric power is capable of being power supplied to the electronic component from the air cell.

US Pat. No. 10,390,699

DETECTION AND RESPONSE SYSTEM FOR OPIOID OVERDOSES

1. A wearable system for detecting an opioid overdose and automatically administering to a wearer a dosage injection of an opioid antidote, the system comprising:a wearable monitor unit, comprising one or more biometric monitors, a GPS receiver, a monitor microprocessor, and a wireless telephone transmitter;
a wearable injector unit, comprising a solenoid switch, an electrical power source, a solenoid having an armature and a solenoid core, a syringe containing a prescribed dosage of the opioid antidote, a hypodermic needle, and a syringe assembly, wherein the syringe has a plunger and an outlet of the syringe is connected to the hypodermic needle through a flexible connection tubing, and wherein the syringe assembly comprises at least one plunger spring connected to the plunger and a release latch connected to the plunger, and wherein the solenoid is electrically connected to the electrical power source through the solenoid switch;
wherein the injector unit further comprises a needle carriage, which carries the hypodermic needle along a carriage track, and wherein the armature of the solenoid has a proximal end, which is closer to the solenoid core, and a distal end, which is further from the solenoid core, and wherein the distal end of the armature is connected to the needle carriage by a carriage bracket;
wherein the monitor unit is configured to be attached to the wearer, such that each of the biometric monitors continuously monitors wearer biometric data and continuously transmits the wearer biometric data to the monitor microprocessor;
wherein the monitor microprocessor is programmed to continuously compare the wearer biometric data with one or more pre-set thresholds indicative of an opioid overdose;
wherein the monitor microprocessor is programmed, upon determining that the wearer biometric data is indicative of an opioid overdose, to obtain current wearer location coordinates from the GPS receiver and to send one or more emergency messages, including the current wearer location coordinates, to one or more emergency contacts using the wireless telephone transmitter;
wherein the monitor microprocessor is programmed, upon determining that the wearer biometric data is indicative of an opioid overdose, to transmit an activation signal to the solenoid switch of the injector unit;
wherein, upon receiving the activation signal, the solenoid switch is configured to complete an energizing circuit, such that the electrical power source energizes the solenoid of the injector unit;
wherein the injector unit is configured so that, when the solenoid is energized, the distal end of the armature, acting though the carriage bracket, pulls the needle carriage toward a needle aperture, through which the hypodermic needle protrudes and inserts into the wearer;
wherein the injector unit is configured so that, upon the solenoid being energized, the armature opens the release latch, thereby releasing the plunger and causing the plunger springs to fully depress the plunger, so as to force the prescribed dosage of the opioid antidote out of the syringe, through the connection tubing, into the hypodermic needle, and through the hypodermic needle into the wearer;
wherein the injector unit is configured, at an end of a dosage injection, to open the energizing circuit, such that the electrical power source ceases to energize the solenoid and the solenoid is de-energized; and
wherein the injector unit is configured, upon the solenoid being de-energized, to retract the hypodermic needle, such that the syringe ceases to inject the opioid antidote into the wearer.

US Pat. No. 10,390,697

TRIAL FRAME

OCULUS OPTIKGERAETE GMBH,...

1. A trial frame for determining the subjective refraction of a subject, comprising:first and second lens holder devices for receiving insert lenses,
a bridge which connects the first and second lens holder devices in such a manner that their distance relative to each other is adjustable,
a nose rest device having a pivotable and height-adjustable nose rest; and
first and second temples, which are adjustable in length and height, the nose rest device having an adjustment gear for adjusting the height of the nose rest,the adjustment gear having a toothed rack and a bevel worm wheel which are engaged with each other.

US Pat. No. 10,390,687

ENDOSCOPIC SURGICAL INSTRUMENTS

Samsung Electronics Co., ...

1. An endoscopic surgical instrument, comprising:two surgical instrument modules, each of which is provided with a surgical instrument portion;
an endoscopic module configured to form a triangular shape with the two surgical instrument modules and configured to image operations of the surgical instrument modules at different angles using a plurality of joints;
a drive portion including a motor to generate drive forces; and
a connection portion to connect the endoscopic module and the drive portion,
wherein wires connecting respective members coupled by the plurality of joints are configured to amplify drive forces of the drive portion applied to the plurality of joints,
wherein the plurality of joints comprise rolling joints at which teeth of gears engage and rotate with each other,
wherein the plurality of joints provide three or more degrees of freedom to the endoscopic module,
wherein the endoscopic module includes a head portion and an arm portion,
wherein the head portion includes a first gear portion, a second gear portion and a camera mounted in the head portion, the first gear portion including first teeth, the second gear portion including second teeth and third teeth, the second teeth being at a first side of the second gear portion for matching with the first teeth to allow the head portion to rotate in left and right directions together with the first gear portion, and the third teeth being at a second side of the second gear portion, and the camera being mounted in the head portion to image the operations of the surgical instrument modules,
wherein the arm portion is connected to the drive portion through the connection portion and connected to the head portion, the arm portion including a third gear portion, the third gear portion including fourth teeth at a first side of the third gear portion to match with the third teeth of the second gear portion to allow the head portion to rotate in upward and downward directions together with the connection portion and the second gear portion, and
wherein a direction in which the second teeth extend on the first side of the second gear portion forms a right angle with a direction in which the third teeth extend on the second side of the second gear portion.

US Pat. No. 10,390,684

DRAIN DEVICE

GUANGDONG YINGAO KITCHEN ...

1. A drain device, comprising a first tank body, a second tank body, a third tank body and a drain rack, wherein a bottom surface of the first tank body is mounted and fixed to a top surface of the second tank body, a bottom surface of the second tank body is mounted and fixed to a top surface of the third tank body, the first tank body, the second tank body and the third tank body are in communication with one another to form a washing cavity, a bottom inner side wall of the first tank body is provided with two steps in a lengthwise direction of the first tank body, an inner side wall of the third tank body is provided with two receiving portions in a lengthwise direction of the third tank body, the cross-sectional area of the second tank body gradually increases from top to bottom, the cross-sectional area of the third tank body gradually decreases from top to bottom, the distance between the two steps is equal to the distance between the two receiving portions, and the two steps and the two receiving portions are all configured for supporting the drain rack, and wherein the drain rack spans a space formed between the two steps or a space formed between the two receiving portions.

US Pat. No. 10,390,666

TOILET SEAT TIGHTENING KIT

Ginsey Industries, Inc., ...

1. A toilet seat tightening kit comprising:a screwdriver comprising a shaft;
one or more washers configured to fit over the shaft of the screwdriver; and
a wrench comprising a wrenching portion and a handle extending longitudinally therefrom, wherein at least a portion of the wrench defines an interior cavity with an opening;
wherein the screwdriver and the wrench are configured to mate with one another, while the one or more washers are positioned on the shaft of the screwdriver, by the shaft of the screwdriver fitting into the interior cavity via the opening of the wrench to form a unitary structure.

US Pat. No. 10,390,665

TOILET SEAT WITH WINGS AND STABILIZING MEMBERS

COMFORT PLUS LLC, Las Ve...

1. A toilet seat comprising:a. a single piece having a top portion and a bottom portion;
b. said top portion including a top surface having a central open area;
c. said bottom portion having a first interior partial circumferential wall with a first interior partial circumferential bottom surface that partially surrounds said central open area and a second interior partial circumferential wall at a spaced apart radial distance from the first interior partial circumferential wall with a second interior circumferential bottom surface,
d. a multiplicity of spaced apart transverse stabilizing ribs extending in a radial horizontal direction from the first interior circumferential wall past the second interior circumferential wall by individual radial distances and then extending at an upward slope until each respective multiplicity of spaced apart transverse stabilizing ribs join an exterior circumferential wall, the horizontal portion of said transverse stabilizing ribs and the upwardly sloped portion of said transverse stabilizing ribs positioned below said top section; and
e. the respective bottom surfaces of the first and second interior circumferential walls and the horizontal section of said transverse stabilizing ribs forming a stabilizing platform for the toilet seat.

US Pat. No. 10,390,658

OIL LEVEL DETECTION SYSTEM FOR DEEP FAT FRYER

Pitco Frialator, Inc., B...

1. A deep fat fryer, comprising:a vat suitable to hold a volume of cooking liquid, the vat in thermal communication with a heat source and configured to provide heat to the cooking liquid when disposed within the vat, and
a liquid level detector disposed within the vat, the liquid level detector comprising a heat producing element and a temperature sensor disposed in contact with the heat producing element and configured to provide a first output signal representative of a surface temperature of the heat producing element, wherein the detector comprises a shell that supports and encloses the temperature sensor and the heat producing element, wherein the heat producing element contacts the shell to allow for conductive heat transfer therebetween;
further comprising a control system in communication with the temperature sensor and the heat producing element, the control system configured to monitor the first output signal from the temperature sensor and selectively energize and deenergize the heat producing element, wherein the control system is operatively connected with a pump and the vat is fluidly connected with the pump, wherein the control system is configured to selectively provide a second signal to operate the pump to urge cooking liquid to flow to the vat to increase the volume of cooking liquid within the vat.

US Pat. No. 10,390,656

COOKING DEVICE AND COMPONENTS THEREOF

SHARKNINJA OPERATING LLC,...

1. A cooking system for cooking food, the cooking system comprising:a housing defining a hollow chamber configured to receive a food container, said housing having an upper portion defining an opening to said hollow chamber;
a food container having a hollow container interior and being positionable within said hollow chamber, wherein an end of said food container extends above said upper portion of said housing when said container is installed within said hollow chamber;
a first lid attachable to said housing and moveable between a first position that covers said upper portion of said housing and said opening to said hollow chamber when said food container is installed within said hollow chamber and a second position where said first lid does not cover said opening to said hollow chamber,
a second lid attachable to said housing to cover said upper portion of said housing and said opening to said hollow chamber; and
at least one heating element disposed in said first lid.

US Pat. No. 10,390,655

TWO SIDED GRILL WITH MOVABLE LOWER PLATE

Taylor Commercial Foodser...

1. A grill comprising:a base structure;
a lower platen assembly connected to the base structure and including a lower grilling plate;
an upper platen assembly movably connected to the base structure such that the upper platen assembly is movable between a raised position and a lowered position, the upper platen assembly including an upper grilling plate, a handle, and an arm;
a plurality of leveling mechanisms, each being mounted to the base structure and arranged in contact with the lower grilling plate, the plurality of leveling mechanisms being configured to move the lower grilling plate relative to the upper grilling plate; and
a latch mechanism mounted to the base structure, the latch mechanism being configured to selectively couple to the arm to retain the upper platen assembly in the lowered position, wherein during operation, power is provided to one of the upper grilling plate and the lower grilling plate, and if the grill loses power, the latch mechanism is configured to decouple from the arm.

US Pat. No. 10,390,649

DIFFUSER FOR BEVERAGES

JIN HONG DA ENTERPRISE CO...

1. A diffuser for beverages comprising: a container, a cover, an outer diffuser body, an inner diffuser body, and a diffuser cover, wherein:the container has a bottom portion and a sidewall to form a containment space with a main opening;
the cover has a stepped assembly opening, the assembly opening provided with a first lip, a first stopping rim, a second lip, and a second stopping rim, the second lip having a plurality of rotation slots, each rotation slot having a closed end and an open end, the open end passing through the first stopping rim, the cover sized to removably engage the container to overlap the main opening;
the outer diffuser body has a cup-shaped body with at least one side opening, the outer diffuser body sized to pass through the assembly opening to be disposed in the container, the cup-shaped body further comprising a third rim sized to engage the second stopping rim of the cover so that the cover engages with the outer diffuser body;
the inner diffuser body has a cup-shaped body corresponding to the outer diffuser body, the inner diffuser body having a filtering portion with a plurality of filtering apertures on a sidewall of the inner diffuser body and a plurality of positioning protrusions disposed on an outer surface of the inner diffuser body, the inner diffuser body configured to be placed in the outer diffuser body through the assembly opening, each positioning protrusion aligning with the open end of a corresponding rotation slot, and by rotating the inner diffuser body, each positioning protrusion moves between the open end and the closed end of the corresponding rotation slot to cause the filtering portion of the inner diffuser body to align with the side opening of the outer diffuser body or to be offset away from the side opening to fluidly connect or separate the container and the inner diffuser body; and
the diffuser cover is sized to removably engage the cover for covering the assembly opening of the cover.

US Pat. No. 10,390,647

FLOOR MATTING

Parallax Group Internatio...

1. A floor mat comprising:a body comprising a first surface and a second surface bound by an interlocking peripheral wall comprising a first edge, a second edge, a third edge, a fourth edge, a first corner, a second corner, a third corner, and a fourth corner;
wherein each of the first, second, third, and fourth corners comprises a first tooth and a second tooth disposed on adjacent edges of the corner;
wherein a width of a stem of the first tooth is shorter than a width of a stem of the second tooth; and
wherein a width of a cap of the second tooth extends beyond the adjacent edge.

US Pat. No. 10,390,645

BOTTLE STORAGE BRACKET

Glenn Vogel, Evergreen, ...

1. A bracket for securely storing a bottle, comprising:a clip comprising a flexible enclosure configured to receive a neck of the bottle;
a connector coupled with the clip, wherein the clip is configured to be detached from the connector to receive the neck of the bottle;
a base coupled with the connector, the base comprising a flexible semi-circular enclosure that includes a linear opening that is configured to receive a body of the bottle; and
a mounting face configured to securely mount the bracket flush with a vertical mounting surface and configured to receive an entire bottom surface of the bottle, wherein the bottom surface is oriented orthogonal to the vertical mounting surface and configured to be secured to the vertical mounting surface via a plurality of connection points.

US Pat. No. 10,390,644

ACCORDION SLEEVE FOR A BEVERAGE CONTAINER

Grisha Lachinian, Simi V...

1. A method of utilizing a beverage container sleeve to maintain an existing beverage container within an existing, movable cup holder, said method comprising the steps of:providing an existing, movable cup holder;
providing an existing beverage container;
providing a beverage container sleeve including a body having an accordion configuration provided with a centrally registered longitudinal axis, said body including an exterior surface and an interior surface oppositely position therefrom, said interior surface including a thermally insulative layer; an upper portion, a bellowed portion, and a lower portion, wherein said bellowed portion interconnects said upper portion to said lower portion;
slidably positioning said beverage container sleeve about the existing beverage container;
selectively compressing and decompressing said bellowed portion of said beverage container sleeve between folded and unfolded positions; wherein, when said bellowed portion is compressed to said folded position, said bellowed portion is outwardly displaced away from the centrally registered longitudinal axis and thereby has a greater latitudinal width and a shortened longitudinal length; and
while said bellowed portion is at said folded position, contemporaneously positioning said beverage container sleeve and the existing beverage container within the existing, movable cup holder such that said bellowed portion maintains frictional engagement with an interior surface of the existing, movable cup holder;
wherein said bellowed portion includes a first bellow section, a second bellow section, and a third bellow section, said second bellow section being directly and continuously connected to each of said first bellow section and said third bellow section;
wherein each of said upper portion and said lower portion has a fixed diameter;
wherein said interior surface at each of said upper portion and said lower portion are smooth, planar and uninterrupted.

US Pat. No. 10,390,640

DRINKING VESSEL PRODUCTS

Liquor Appeal (PTY) Ltd.,...

1. A drinking vessel, comprising:a body defining an inner cavity, a consumption opening that is in communication with the inner cavity, and a fill opening and fill passage that are in communication with the inner cavity, said fill opening being substantially smaller than the consumption opening and being on an opposite side of the inner cavity, from the consumption opening;
a removable seal extending across the consumption opening in a sealing manner; and
a stop formation that is insert able into the fill passage to seal the fill opening;
wherein at least one clip is defined on the stop formation and at least one vent groove is defined between the stop formation and the fill passage, the stop formation being configured to travel along the fill passage while gas is vented along the vent groove, and said clip holding the stop formation in place when the stop formation has been fully inserted in the fill passage, to seal the fill opening.

US Pat. No. 10,390,638

SMART PILLOW SYSTEM AND MANUFACTURING METHOD THEREFOR

GIOCLAVIS CO. LTD., Suwo...

1. A smart pillow system including a pillow, wherein one air mesh is provided with a speaker-shaped groove and a line-shaped groove by cutting each of locations at which a speaker and a wire are inserted, the speaker is attached to the speaker-shaped groove by an adhesive, the wire is inserted into the line-shaped groove and is tied by a cable tie to be fixed, the adhesive is applied along the line-shaped groove into which the wire is inserted, the speaker is attached with a mesh-shaped membrane for waterproofing, a communication unit for transmitting and receiving a signal to and from a user terminal is connected to the wire, other air meshes are laminated above and under the one air mesh, and the other air meshes including the one air mesh are covered with a pillow-shaped outer cover,wherein the pillow generates an alarm signal when sensing that a sleeper wakes up from a sleeping state and is thus in a non-sleeping state, measures a brainwave of the sleeper and transmits a measured brainwave information of the sleeper to the user terminal through the communication unit along with the alarm signal, and receives a sound sleep control signal based on the brainwave information of the sleeper from the user terminal to output a music or a sound to enable the sleeper to get a sound sleep in which the brainwave of the sleeper is a delta wave, and the user terminal receives from the pillow the brainwave information of the sleeper along with the alarm signal notifying that the sleeper wakes up from the sleeping state and transmits the sound sleep control signal including the music or the sound suitable to enable the sleeper to keep the sound sleep based on the brainwave information of the sleeper to the pillow, and
wherein when more than one pillow is present around the user terminal, the user terminal is operated as a first master terminal and a first pillow at a shortest distance from the user terminal is operated as a first slave terminal to transmit the sound sleep control signal from the user terminal that is the first master terminal to the first pillow that is the first slave terminal and the first pillow is operated as a second master terminal when a second pillow is present at the shortest distance therefrom and the second pillow is operated as a second slave terminal to transmit the sound sleep control signal from the first pillow that is the second master terminal to the second pillow that is the second slave terminal, and thus the pillows adjacent to each other at a short distance are operated as the master terminal and the slave terminal to operate an N?1-th pillow as an N-th master terminal when an N-th pillow is present at the shortest distance therefrom and operate the N-th pillow as an N-th slave terminal to thereby transmit the sound sleep control signal from the N?1-th pillow that is the N-th master terminal to the N-th pillow that is the N-th slave terminal, such that as the sound sleep control signal is sequentially transmitted through a linear network from the first pillow to the N-th pillow, the first pillow to the N-th pillow are operated based on the sound sleep control signal.

US Pat. No. 10,390,635

CARRIER BAG DISPENSERS, CARRIER BAG DISPENSER CAROUSEL, HOLD MEMBER FOR HOLDING AND RETAINING A MULTITUDE OF PAIRS OF STRAPS CONNECTED TO RESPECTIVE CARRIER BAGS AND KIT-OF-PARTS CARRIER BAG DISPENSER FOR HOLDING A STACK OF CARRIER BAGS

Mettler Packaging LLC, R...

1. A hold member for holding and retaining a multitude of pairs of carrying straps connected to respective carrier bags, wherein said hold member comprises:a fastening section for fastening the hold member to a bag dispenser,
a retaining section located, in use, above the fastening section having a front side, a rear side, and opposing side edges, and
a support section for the carrying straps located on the rear side of the hold member,
wherein the rear side of the retaining section comprises a multitude of grooves extending from one side edge to an opposing side edge, and
wherein the retaining section and the fastening section of the hold member are resiliently connected by at least one spring screw.

US Pat. No. 10,390,627

BED FRAME ASSEMBLED BY SNAPPING WEDGE INSERTS INTO SLOTS

Zinus Inc., Tracy, CA (U...

1. A bed frame assembly comprising:a lateral bar;
a support leg with a rectangular cross section that has a first side, a second side and a slot, wherein the first side is perpendicular to the second side and meets the second side at an edge, wherein the lateral bar is attached to the support leg and extends perpendicular to the support leg from the second side, and wherein the slot is disposed on and extends from the first side; and
a wedge insert attached to a longitudinal bar, wherein the longitudinal bar has an upper surface and a lower surface, wherein the wedge insert fits into the slot, wherein the longitudinal bar is oriented perpendicular to the support leg while the wedge insert is lodged in the slot, and wherein no portion of the slot is disposed below the lower surface or above the upper surface of the longitudinal bar while the wedge insert is lodged in the slot.

US Pat. No. 10,390,626

ASSEMBLABLE MATTRESS SUPPORT WHOSE COMPONENTS FIT INSIDE THE HEADBOARD

Zinus Inc., Tracy, CA (U...

1. A mattress support comprising:a longitudinal bar with a first portion and a second portion, wherein the first portion has a first connector, and the second portion has a second connector, wherein the first portion and the second portion have a combined length;
a headboard with an attachment location for a third connector, an inner compartment and an outside, wherein the attachment location for the third connector is disposed outside the inner compartment, and wherein the first connector is configured to attach directly to the third connector on the outside of the headboard; and
a footboard with an attachment location for a fourth connector, wherein the second connector is configured to attach directly to the fourth connector, wherein the longitudinal bar and the footboard fit inside the inner compartment of the headboard, and wherein the inner compartment has an inner length that is shorter than the combined length of the first portion and the second portion.

US Pat. No. 10,390,623

NECK PILLOW WITH COMPARTMENT FOR BLANKET

Beekaysage LLC, Jersey C...

1. A pillow comprising:a pillow casing having a u-shaped section having opposing ends, a first extension section extending outward of a first of the opposing ends, and a second extension section extending outward of a second of the opposing ends,
a u-shaped stuffed pillow disposed within the u-shaped section of the pillow casing and between the extension sections, the u-shaped stuffed pillow having the same essential shape and size of the u-shaped section,
the first of the opposing ends of the u-shaped section and the interior of the first extension section defining a first pocket located within the first extension section, the second of the opposing ends of the u-shaped section and the interior of the second extension section defining a second pocket located within the second extension section,
the first extension section having a first distal end and a first concave inner periphery adjacent to the first distal end, the first concave inner periphery having an opening that provides access to the first pocket, the second extension section having a second distal end and a second concave inner periphery adjacent to the second distal end and the first concave inner periphery, the second concave inner periphery having an opening that provides access to the second pocket,
a first rectangular-shaped blanket half separate from the pillow and removably located within the first pocket of the first extension section, and
a second rectangular-shaped blanket half separate from the pillow and removably located within the second pocket of the second extension section,
wherein each of the blanket halves comprises a plurality of complementary fasteners along a straight side of each of the blanket halves for attaching the blanket halves directly together to each other at the fasteners along each of the straight sides to form a single continuous blanket comprising the first blanket half and the second blanket half, wherein the single continuous blanket is configured to be over or covering a user,
wherein each of the blanket halves further comprises a first connector located on each of the blanket halves and the pillow further comprises two second connectors, wherein each of the two second connectors is releasably connected to each of the first connectors,
wherein each of the second connectors is attached through the inside of the respective pocket, within each of the extension sections, to the stuffed pillow, and
wherein the openings to the pockets are further configured to allow the single continuous blanket comprised of the attached blanket halves to be adapted to cover a user whose neck is resting within the u-shaped section.

US Pat. No. 10,390,616

PRODUCT DISPLAY ASSEMBLY AND METHOD

iSee Store Innovations, L...

1. A product display assembly configured to display beverage containers, the assembly comprising:a body defining an interior volume, the body comprising a base;
at least one support mounted to the base of the body, the support disposed within the interior volume, the support comprising a foot and a stem extending from the foot, wherein the foot is mounted to the base of the body and defines a foot plane, the stem extending from the foot at an oblique angle to the foot plane;
at least one product holder mounted to the at least one support, the product holder configured to hold a product at an orientation that is oblique to the foot plane; and
a simulated ice portion mounted to an upper portion of the body, the simulated ice portion extending from the interior volume.

US Pat. No. 10,390,605

GROOMING BRUSH

ANIPURE PET PRODUCTS INC....

1. A hair brush, comprising:a planar base member having two major faces, said base member being formed with a plurality of shallow recesses on one of said faces, two of said recesses being spaced from one another by an elongate area, said base member being formed with at least one elongate groove or elongate indentation on the other of said faces, said groove or elongate indentation being opposed to and parallel with said elongate area; and
a plurality of bristle plates each mounted to said base member and seated in a respective one of said shallow recesses, each of said bristle plates being provided along one major surface with a multiplicity of tines, said bristle plates being substantially rigid at room temperature.

US Pat. No. 10,390,594

INDUCTIVELY CHARGEABLE EARBUD CASE

Apple Inc., Cupertino, C...

1. A case for a pair of earbuds, the case comprising:a housing having first and second cavities formed within the housing, the first cavity sized and shaped to hold a left earbud in the pair of earbuds and the second cavity sized and shaped to hold a right earbud in the pair of earbuds;
a lid attached to the housing and operable between a closed position where the lid is aligned over the first and second cavities and an open position where the first and second cavities are exposed enabling the pair of earbuds to be removed from or placed within the case;
a connector having a connector cavity with an opening at the bottom surface of the case and a plurality of contacts positioned within the opening;
a rechargeable battery disposed within the housing;
one or more wireless power receiving elements disposed within the housing and configured to receive electric charge from a wireless power transmitter during a charging event in which the case is positioned proximate to the wireless power transmitter; and
a charging system operatively coupled to receive power from the one or more wireless power receiving elements and transfer the received power to the rechargeable battery.

US Pat. No. 10,390,585

SHOE

BECAUSE INTERNATIONAL, N...

1. An article of footwear comprising:a sole having a toe, medial side, lateral side, and heel, wherein at least the toe, medial side and lateral side of the sole extend and wrap upwardly;
a toe cap extending from the toe of the sole;
a vamp member adjustably connected to a free end of the toe cap;
at least one medial strap connecting the vamp member to the medial side of the sole;
at least one lateral strap connecting the vamp member to the lateral side of the sole; and
an adjustable heel strap connected to the medial and lateral sides of the sole and extending around the heel of the sole.

US Pat. No. 10,390,583

FOOTWEAR WITH REFRACTIVE INTERNAL ILLUMINATION

1. A footwear with refractive internal illumination comprising:a footwear;
a translucent body;
an illumination system;
the footwear comprising a sole section and an upper;
the upper comprising an opaque light refracting section and a liner;
the illumination system comprising a power source and at least one light source;
the at least one light source being electrically connected to the power source;
a light wavelength of light emitted from the at least one light source being approximate to a light wavelength of the opaque light refracting section;
the upper being connected to the sole section;
the at least one light source being connected to the translucent body;
the translucent body being housed in between the opaque light refracting section and the liner;
the translucent body being configured to refract light, the footwear being configured such that the light then reflects between the translucent body and the opaque light refracting section, the opaque light refracting section being configured to then refract the light to create twice-refracted light, whereby the twice-refracted light internally illuminates the opaque light refracting section;
the translucent body comprising a plurality of refractive boundary sections;
the plurality of refractive boundary sections comprising a plurality of cavities;
the translucent body comprising a first refractive index;
each of the plurality of refractive boundary sections comprising a second refractive index; and
the translucent body being configured to refract light at the first refractive index, the plurality of cavities being configured to refract light at the second refractive index, the footwear being configured such that the first refractive index of light and the second refractive index of light then reflect between the translucent body and the opaque light refracting section, the opaque light refracting section being configured to then refract the first refractive index and second refractive index of light to create twice-refracted light, whereby the first refractive index of twice-refracted light and the second refractive index of twice-refracted light internally illuminate the opaque light refracting section, and whereby the second refractive index of twice-refracted light appears as brighter points of light on the opaque light refracting section as compared to the first refractive index of twice-refracted light.

US Pat. No. 10,390,582

PROTECTIVE HEADGEAR

TWO GUYS AND A HAT INC., ...

1. An adjustment mechanism for headgear comprising:a forward portion having a first end and a second end adapted to partially circumscribe a forward portion of a wearer's head;
a first rear strap adapted to partially circumscribe a rear portion of a wearer's head;
a second rear strap to partially circumscribe a rear portion of a wearer's head opposite the first rear strap;
the first end of the forward portion connected to the first rear strap at a first union, wherein the first end of the forward portion and the first rear strap are positioned on opposite sides of an intermediate layer at the first union; and
the second end of the forward portion connected to the second rear strap at a second union, wherein the second end of the forward portion and the second rear strap are positioned on opposite sides of the intermediate layer at the second union.

US Pat. No. 10,390,574

HAND COVER SYSTEM

1. A hand protection system comprising:an exterior structure including a finger sheath and a thumb sheath;
a sealing structure coupled to the finger sheath of the exterior structure, the sealing structure including an inner extension and an outer edge, the outer edge including magnets in a piping, the sealing structure enabling an open configuration and a closed configuration; and wherein:
the open configuration includes the sealing structure split apart and the exterior structure folded back on itself for allowing a user's hand to be exposed from between the sealing structure, and
the closed configuration includes the magnets of the sealing structure maintaining the sealing structure together for covering the user's hand, and the inner extension extended in from the outer edge for providing a smooth transition, a moisture barrier, and a fold for locking the protection system into the closed configuration by being configured to be placed underneath the user's hand.

US Pat. No. 10,390,569

YOGA BAND LEGGINGS AND METHOD OF MANUFACTURING THE SAME

LENNON LEASING, LLC, Cor...

1. A method of manufacturing leggings having a leg portion and a waistband portion, using a fabric, the method comprising:brushing an outside surface of the fabric once to form a single-brushed surface;
brushing an inside surface of the fabric exactly three times to form a triple-brushed surface;
cutting the fabric into a plurality of leg pieces for the leg portion and a plurality of waistband pieces for the waistband portion;
sewing or stitching the plurality of leg pieces for the leg portion and the plurality of waistband pieces for the waistband portion together, the waistband portion having a top edge and a bottom edge, a length of the top edge of the waistband portion being smaller than a length of the bottom edge of the waistband portion, the bottom edge of the waistband portion being connected to a top edge of the leg portion, the single-brushed surface of the fabric forming an inside leg surface configured to contact legs of a wearer of the leggings, the triple-brushed surface of the fabric forming an outside leg surface, a front outside waistband surface, and a rear outside waistband surface; and
sewing or stitching an elastic band to the top edge of the waistband portion.

US Pat. No. 10,390,568

FOOTWEAR ARTICLE PROVIDED WITH MEANS FOR HOLDING OR ATTACHING AN OBJECT ON SAID ARTICLE

FEETKIT, Paris (FR)

1. A footwear article, made of deformable flexible material, comprising:first and second sleeves, which are substantially cylindrical, arranged at an angle of between approximately 90° and 135° with respect to each other, an area of joining between the first and second sleeves corresponding to a heel, the first sleeve is open at an end opposite the heel and the second sleeve is closed at an end opposite the heel to receive toes of a user; and
an object holder configured to hold at least half of an object which at least one dimension is less than at least one other dimension, on the first sleeve, either in a rear left or a front right 90° quarter for the footwear article for a right foot, or in a rear right or a front left 90° quarter for the footwear article for a left foot, in a cross section of a plane transverse to a longitudinal axis of the first sleeve relative to a longitudinal axis of the second sleeve.

US Pat. No. 10,390,566

HEATING DEVICE FOR ELECTRONIC CIGARETTE AND ATOMIZER HAVING SAME

SHENZHEN FIRST UNION TECH...

1. A heating device for an electronic cigarette, comprising:a heating part, the heating part having a hollow metallic tube wound in a spiral form, an inner tubal passageway being formed in the hollow metallic tube and extending in the same spiral form as the metallic tube, and an outer passageway being formed via being surrounded by the spiral metallic tube;
a first conductive part electrically connected to a first end of the metallic tube;
a second conductive part electrically connected to an opposite second end of the metallic tube.

US Pat. No. 10,390,558

AEROSOL-GENERATING ARTICLE COMPRISING A TRANSPARENT TUBE

Philip Morris Products S....

1. An aerosol-generating article comprising:an aerosol-generating substrate;
a mouthpiece secured to the aerosol-generating substrate, the mouthpiece comprising at least one filter segment and a substantially transparent tubular segment axially aligned in an abutting end-to-end relationship with the at least one filter segment and defining an empty cavity extending substantially longitudinally through the substantially transparent tubular segment, wherein aerosol passing through the empty cavity during use of the aerosol-generating article is visible from the exterior of the aerosol-generating article through the substantially transparent tubular segment.

US Pat. No. 10,390,551

PROCESSING LUPINES

Black Acom Ventures, San...

1. A lupine processing method comprising:receiving, by a tank, whole lupines for processing;
receiving water into the tank;
hydrating the whole lupines by the water in the tank;
agitating the whole lupines by a mechanical agitator;
thermally shocking the whole lupines at a specified frequency;
circulating the water through the tank; and
removing selected constituents of the whole lupines by the circulating water.

US Pat. No. 10,390,549

PARTIAL CALCIFICATION OF FREE FATTY ACID MIXTURES, LIVESTOCK FEED COMPOSITIONS INCLUDING THEM, AND METHODS OF MAKING SAME

ENERGY BOOSTER NEWCO, LLC...

1. A composition comprising:a solidified particulate mixture of free fatty acid; and
a calcium salt of a fatty acid;
wherein the composition has an onset melt point of from 140° F. to 170° F.

US Pat. No. 10,390,543

FOAMING AND EMULSIFYING PROPERTIES OF HIGH PRESSURE JET PROCESSING PASTEURIZED MILK

The Penn State Research F...

1. A method for preparing a food additive comprising a processed pasteurized skim milk component that exhibits a foam volume stability index (FVS) that is improved relative to a FVS of pasteurized skim milk that has been subjected to High Pressure Jet Processing (HPJ) at a hydrostatic pressure of 500 MPa, the method comprising subjecting the pasteurized skim milk to HPJ, at a hydrostatic pressure of 400 MPa, the method further comprising mixing the pasteurized skim milk subsequent to exposing to the hydrostatic pressure of 400 MPa to provide as the food additive the foam that exhibits the improved FVS.

US Pat. No. 10,390,496

ENVIRONMENTAL CONTROL SYSTEM FOR PLANT GROWTH MANAGEMENT

1. A system for supply of conditioned gases to an environmentally controlled enclosure (ECE) that monitors transpiration rates of plants in the ECE and controls properties of conditioned gases provided to the ECE, said system comprising:a gas inlet system, said gas inlet system comprising a makeup gas inlet for receiving makeup gas and a recirculated gas inlet for receiving recirculated gas, which are mixed to provide an inlet gas;
a variable mass flow inlet fan for regulation of mass flow of conditioned gases to the ECE;
a chilling system for cooling gases collected at said gas inlet system;
a heating system for heating gases discharged from said chilling system;
an ECE inlet;
an ECE outlet;
a recirculation system, said recirculation system configured to normally return a portion of exhaust gases from said ECE outlet as recirculated gas to said recirculated gas inlet, and to normally exhaust a portion of said exhaust gases from said ECE through an outlet vent;
a variable mass recycle fan to maintain pressure in said ECE at a selected pressure setpoint, said variable mass recycle fan configured for transfer of exhaust gases from said ECE to said recirculation system;
a control system comprising sensors and data transmitters for (a) dry bulb temperature, (b) wet bulb temperature, to determine the properties of gases at each of (1) said makeup gas inlet, (2) said outlet of said variable mass inlet fan, and (3) said ECE outlet, (c) pressure sensors and transmitters to determine the properties of gases at each of (1) said outlet of said variable mass inlet fan and (2) at said ECE outlet, and (d) a mass flow measurement device at said outlet of said variable mass inlet fan;
said control system further comprising a programmable logic controller, the programmable logic controller configured for receiving data from said mass flow measurement device and from each of said dry bulb and said wet bulb temperature sensors, pressure sensors, and configured to simultaneously and independently control (a) the mass of conditioned gases entering the ECE by varying the mass output of said inlet fan, and (b) the absolute humidity of conditioned gases entering the ECE, and (c) the dry bulb temperature of conditioned gases entering the ECE, by cooling and heating the gases collected by the gas inlet system as necessary to achieve an absolute humidity, dry bulb temperature for mass of conditioned gases entering the ECE; and
said programmable logic controller further configured to (a) calculate and record transpiration rates of plants in said ECE, as indicated by an amount of water vapor added to the conditioned gases entering the ECE which occurs during transformation of the conditioned gases to exhaust gases leaving the ECE, and (b) to operate the system to control absolute humidity and temperature of the conditioned gases at said outlet of said variable mass inlet fan.

US Pat. No. 10,390,494

HYDROPONIC ELECTROCULTURE SYSTEM AND METHODS OF USE

Nano Evaporative Technolo...

1. An electroculture system for use in a hydroponic growing environment having at least one container configured for supporting at least one plant such that the roots of said plant are able to extend down into a volume of fluid positioned within the container, along with at least one supply line, return line and pump configured for circulating the fluid through the container, the electroculture system comprising:at least one electroculture unit positionable in fluid communication with at least one of the at least one container, supply line, return line and pump, the at least one electroculture unit comprising:
a conductive core comprising:
an absorbing layer capable of being saturated with the fluid and having a first surface and an opposing second surface;
a first conductive layer attached to the first surface of the absorbing layer; and
a second conductive layer attached to the second surface of the absorbing layer, such that the absorbing layer is sandwiched between the first and second conductive layers and the first conductive layer is spaced apart from the second conductive layer;
a porous layer encapsulating the conductive core, the porous layer constructed of a gypsum-ceramic casting;
at least one first electrical wire in electrical communication with the first conductive layer; and
at least one second electrical wire in electrical communication with the second conductive layer;
whereby, an electrical current is selectively deliverable to each of the first and second conductive layers via the at least one first electrical wire and second electrical wire, respectively, which, in turn, forms a reaction within the absorbing layer that causes an off-gassing of oxygen and hydrogen in the form of bubbles to be delivered, along with the electrical current in the fluid, to the roots of the at least one plant in the at least one container.

US Pat. No. 10,390,482

POWER EQUIPMENT WITH CYLINDER DEACTIVATION ENGINE

Honda Motor Co., Ltd., T...

1. Power equipment, comprising:an equipment main body provided with a propelling device;
a power source for selectively powering the propelling device;
an internal combustion engine having a plurality of cylinders and supported by the equipment main body, the engine including a throttle valve for adjusting a flow of air or mixture into the cylinders of the engine;
an engine control unit for controlling the throttle valve of the engine, and selectively deactivating at least one of the cylinders;
a work implement connected to the engine in a power transmitting relationship;
a clutch provided in a power transmission path between the engine and the work implement; and
a central control unit for controlling an operation of the propelling device, the clutch and the engine control unit;
wherein the central control unit is configured to cause the engine control unit to operate the engine at a prescribed rotational speed with two or more of the cylinders kept activated when the clutch is engaged and the propelling device is propelling the power equipment forward, and to deactivate at least one of the cylinders when an opening of the throttle valve is below a first prescribed value for a prescribed time period while the clutch is maintained engaged and the propelling device is propelling the power equipment forward, and
wherein the central control unit is configured to reactivate at least one of the cylinders that are previously deactivated when the opening of the throttle valve is above a second prescribed value greater than the first prescribed value, and a rotational speed of the engine is not within a prescribed tolerance range defined as the prescribed rotational speed ± a prescribed value, and
wherein the work implement consists of a cutting blade housed within a mower deck, and the clutch consists of a blade clutch.

US Pat. No. 10,390,481

NOZZLE, VALVE, AND MANIFOLD ASSEMBLY FOR PRECISION APPLICATION OF CROP PROTECTANT

BLUE RIVER TECHNOLOGY INC...

1. A device for applying a treatment fluid to plants in a field comprising:a plurality of manifolds, each manifold comprising:
a plurality of nozzles each comprising a nozzle exit and a nozzle inlet, the nozzle exit oriented to substantially face the field, the nozzle exits collectively aligned parallel to a nozzle axis that is substantially perpendicular to a seed line of the plants in the field,
a plurality of valve assemblies, the valve assemblies and nozzles fluidically coupled to each other such that each nozzle is coupled to one or more valve assemblies or vice versa, each valve assembly comprising a valve exit coupled to the corresponding nozzle inlet;
a manifold assembly coupling the plurality of manifolds;
wherein the plurality of manifolds of the manifold assembly are movably coupled such that the device comprises:
an open state wherein a first and a second of the manifolds are positioned such that there is no overlap between the nozzles of the first and the second manifold along the nozzle axis, and
a nested state wherein the first manifold and the second manifold are positioned such that there is at least some overlap between the nozzles of the first and the second manifold along the nozzle axis.

US Pat. No. 10,390,480

SECONDARY SEED TANK FOR AIR CART SYSTEM

CNH Industrial Canada, Lt...

1. An air cart system, comprising:a container assembly comprising a wheeled frame, a first primary product container, and a second primary product container, wherein the first and second primary product containers are mounted on the wheeled frame;
an air distribution network comprising at least one product conduit configured to deliver a first granular agricultural product and a second granular agricultural product to an agricultural product distribution device;
a first metering device configured to meter the first granular agricultural product from the first primary product container to the at least one product conduit, and a second metering device configured to meter the first granular agricultural product from the second primary product container to the at least one product conduit;
a fill hopper mounted on a side of the container assembly;
a secondary product container mounted on the wheeled frame beneath at least a portion of the first primary product container and at least a portion of the second primary product container, wherein the secondary product container is configured to receive the second granular agricultural product from the fill hopper, and the fill hopper is configured to receive the second granular agricultural product at an opening of the fill hopper and to convey the second granular agricultural product to the secondary product container; and
a third metering device configured to meter the second granular agricultural product from the secondary product container to the at least one product conduit.

US Pat. No. 10,390,479

FLOW CONTROL INSERT FOR AN AGRICULTURAL METERING SYSTEM

CNH Industrial Canada, Lt...

1. A flow control insert for an agricultural metering system, comprising:a head configured to couple the flow control insert to a housing of the agricultural metering system; and
a tongue extending from the head, wherein the tongue is configured to engage a channel in a meter roller of the agricultural metering system having flutes disposed within the channel to substantially block flow of particulate material through the channel in a circumferential direction opposite a rotational direction of the meter roller;
wherein a circumferential extent of the tongue is selected to be greater than a circumferential offset between the flutes of the meter roller.

US Pat. No. 10,390,471

AGRICULTURAL DRILL/PLANTER/COULTER/DISC BLADE WITH SINE WAVE EDGE

1. An agricultural tillage blade comprising:a plate adapted for rotation;
the plate having a front side and a rear side, and having an outer periphery substantially in the shape of a sine curve formed about a circle;
the outer periphery being sharpened to more easily penetrate the soil and cut trash; and
wherein the blade has depressions between projections when viewed from the front side, the depressions and projections being mirror images of each other.
US Pat. No. 10,392,258

METHOD OF PRODUCING HIGH-PURITY LITHIUM CARBONATE AND BARIUM SULFATE FROM DISCARDED LITHIUM SECONDARY BATTERIES

KANGWON NATIONAL UNIVERSI...

1. A method of producing high-purity lithium carbonate and barium sulfate from discarded lithium secondary batteries, the method comprising:(I) providing high-purity lithium phosphate from a discarded lithium secondary battery; and
(II) producing high-purity lithium sulfate from the high-purity lithium phosphate and producing high-purity lithium carbonate and barium sulfate from the high-purity lithium sulfate,
wherein step (II) comprises
(a) mixing high-purity lithium phosphate from step (I) and a sulfuric acid aqueous solution to produce a liquid mixture,
(b) condensing the liquid mixture of step (a) and performing solid-liquid separation on the liquid mixture to obtain high purity lithium sulfate solid,
(c) dissolving the high-purity lithium sulfate solid in water or a sodium hydroxide aqueous solution having a pH value of 12 or higher, and performing solid-liquid separation to obtain a lithium sulfate aqueous solution and a solid-phase lithium phosphate,
(d) adding carbonate, carbonate aqueous solution, or a carbonic acid gas to the lithium sulfate aqueous solution and performing solid-liquid separation to obtain solid-phase lithium carbonate,
(e) finely grinding the solid-phase lithium carbonate and classifying lithium carbonate particles having a particle size of 1 to 5 ?m to produce lithium carbonate slurry,
(f) blowing a carbonic acid gas to the lithium carbonate slurry and dissolving edges of lithium carbonate particles or dissolving and removing minute particles of the lithium carbonate,
(g) performing solid-liquid separation for the lithium carbonate slurry obtained by step (f) to obtain high-purity lithium carbonate having a solid phase, and
(h) adding a soluble barium salt aqueous solution to a filtrate obtained from the solid-liquid separation of step (g) and performing solid-liquid separation to obtain high-purity barium sulfate having a solid phase,
wherein the solid-phase lithium phosphate obtained through the solid-liquid separation of step (c) is used as the liquid mixture of lithium phosphate and sulfuric acid of step (a),
wherein the lithium carbonate particles having a size larger than 5 ?m in the classification of step (e) are additionally grinded until the particle size becomes 1 to 5 ?m, and
wherein the filtrate of step (h), which is formed after performing solid-liquid separation to obtain high purity barium sulfate having a solid phase, is added to the fine grinding of step (e).