US Pat. No. 10,508,422

SHUTOFF SYSTEM FOR WATER VALVE

Waxman Consumer Products ...

1. An automatic valve actuator unit for use with an associated manual shutoff valve configured to permit or restrict the flow of fluid through an associated supply pipe, the unit comprising:a housing;
an attachment mechanism for securing the housing to at least one of the associated supply pipe or manual shutoff valve; and
an actuator at least partially supported by the housing for actuating the associated shutoff valve;
wherein the attachment mechanism includes a clamp assembly having first and second cooperating clamp members, the first and second cooperating clamp members being movable within the housing to adjust a point of attachment of the housing;
wherein the first clamp member includes a clamp block supported for sliding movement within the housing between an upper and lower position, and wherein the second clamp member includes a removable u-shape clamp;
the attachment mechanism including an adjustment member for adjusting the position of the clamp block within the housing, the adjustment member operative to move the clamp block between the upper and the lower positions; and
wherein the adjustment member includes a lead screw including a threaded shaft with a non-circular cross-sectional portion, and a handle member including a tubular portion telescoped over the threaded shaft, the tubular portion including a non-circular cross-sectional portion corresponding in shape to the non-circular cross-sectional portion of the shaft, the handle member being slidable axially along the threaded shaft between a first position whereat the non-circular cross-sections are not axially aligned and the threaded shaft and handle member are not rotationally interlocked, to a second position whereat the non-circular cross-sections are at least partially aligned thereby rotationally interlocking the handle member and the threaded shaft for actuation of the lead screw.

US Pat. No. 10,508,420

SYSTEM AND METHOD FOR EFFECTIVE USE OF A LOW-YIELD WELL

7. A method for operating a low-yield well system comprising the steps of;receiving well pump back pressure information at a control panel from a well back pressure transducer measuring a well back pressure upstream of a flow regulator in well output piping, the flow regulator configured to provide for a uniform flow rate in the well output piping; and
controlling a well pump based on the well pump back pressure information.

US Pat. No. 10,508,415

SWING CONTROL APPARATUS OF CONSTRUCTION EQUIPMENT AND CONTROL METHOD THEREOF

VOLVO CONSTRUCTION EQUIPM...

1. A swing control apparatus for construction equipment comprising;first and second hydraulic pumps and a pilot pump;
a work device including a boom, an arm and a bucket, which are operated by a boom cylinder, an arm cylinder and a bucket cylinder, respectively, driven by hydraulic fluid of the first and second hydraulic pumps;
a work device control valve which is configured to control hydraulic fluid supplied from the first and second hydraulic pumps to the boom cylinder, arm cylinder and bucket cylinder, respectively;
a swing motor for swinging an upper swing body which is driven by hydraulic fluid supplied from one of the first and second hydraulic pumps;
a swing control valve for controlling the hydraulic fluid supplied to the swing motor from the first or second hydraulic pump;
a swing operation lever;
a direction control valve for applying to the swing control valve a pilot pressure supplied by operating the swing operation lever, or a pilot pressure supplied by selecting a semiautomatic swing mode;
at least one electronic proportional variable relief valve installed in the swing motor, which variably controls a preset relief pressure so as to vary a braking torque of the swing motor; and
a controller for applying an electric control signal to the electronic proportional variable relief valve to be relieved so that the relief pressure of the electronic proportional variable relief valve is preset to increase or decrease in order to make a target swing angle become the sum of a swing braking angle predicted from the inertia moment of the upper swing body plus a swing angle detected of the upper swing body, when the semiautomatic mode is selected and the work device is operated during a return swing of the upper swing body;
wherein the controller includes a PD controller for applying a calculated electrical current value to the electronic proportional variable relief valve to be relieved, in which the PD controller is performed with the target swing angle of PD control inputted by the sum of the swing braking angle predicted from the inertia moment of the upper swing body plus the swing angle detected of the upper swing body so that the target swing angle can be reached by compensating the inertia moment of the upper swing body, which varies when the work device is operated during the return swing of the upper swing body.

US Pat. No. 10,508,414

SYSTEM AND METHOD FOR LAYING AN UNDERWATER PIPELINE ON A BED OF A BODY OF WATER

SAIPEM S.P.A., San Donat...

12. A method for laying an underwater pipeline on a bed of a body of water, the method comprising:assembling a string of an underwater pipeline at a construction site by joining together a curved portion of pipe and two straight portions of pipe such that the string includes a curved portion having a shape corresponding to a portion of the bed of the body of water including an escarpment;
connecting: (i) one end of the string to a first vessel, (ii) an opposite end of the string to a second vessel, and (iii) the curved portion of the string to a third vessel;
coupling the curved portion of the string to a stabilizer device by connecting a first end of a stay wire to a first connection point of the curved portion of the string and connecting a second, opposite end of the stay wire to a second connection point of the curved portion of the string;
transferring, in the body of water, the string from the construction site to a laying site in the body of water, said laying site being aligned with a path on the bed of the body of water along which to lay the string, wherein during the transfer, the stabilizer device stabilizes and prevents deformation of a shape of the curved portion of the string and the string lies in the body of water substantially in a horizontal plane within a predetermined distance of a free surface of the body of water;
selectively sinking, via a plurality of floating devices coupled to the string, the string in the body of water to rotate the string in the body of water and arrange the string substantially along a vertical plane above the path on the bed of the body of water along which to lay the string; and
laying the string along the path on the bed of the body of water.

US Pat. No. 10,508,412

CONTROL SYSTEM FOR WORK VEHICLE, AND METHOD FOR SETTING TRAJECTORY OF WORK IMPLEMENT

KOMATSU LTD., Tokyo (JP)...

1. A control system for a work vehicle including a work implement, the control system comprising:a controller programmed to
decide a target profile of a work site,
acquire current position data that indicates a current position of the work vehicle,
acquire current terrain data that indicates a current terrain of the work site,
acquire an amount of movement of the work vehicle from a work start position from the current position data,
decide a target displacement from the amount of movement by referring to target displacement data that indicates the target displacement corresponding to the amount of movement,
decide a target design terrain in which the current terrain is displaced vertically by the target displacement,
set the target design terrain as the target profile,
generate a command signal to move the work implement according to the target profile,
acquire a load to which the work vehicle is subjected,
modify the target profile according to a magnitude of the load, and
generate a command signal to operate the work implement according to the modified target profile.

US Pat. No. 10,508,411

GRADING TOOLS FOR WORK MACHINES AND OPERATION THEREOF

ABI ATTACHMENTS INC., Mi...

1. A grading tool structured for coupling with a work machine, the grading tool comprising:a frame having a width extending from a first side to a second side and a length extending from a first end to a second end;
first and second ground contacting members coupled with the frame at first and second locations along the width of the frame and being rotatable relative to the frame;
a multi-hinged drag bar assembly including:
a plurality of arms rotatably coupled with the frame by respective first hinges,
a carrier member coupled with the plurality of arms, the carrier member extending downward from the plurality of arms toward an underlying ground surface, extending along the width of the frame, and including a first surface extending vertically toward the underlying ground surface and facing toward the first end of the frame,
a drag bar rotatably coupled with the carrier member by a second hinge, the drag bar including an upper portion coupled with the second hinge and extending along the width of the frame, a lower portion extending along the width of the frame and defining a plurality of teeth extending downward from the upper portion, and a second surface facing toward the first surface of the carrier member, the drag bar being rotatable about the second hinge from a first position in which the surface of the drag bar is parallel with and abuts the first surface of the carrier to limit rotation of the drag bar to a second position in which the second surface is at an angle relative to and spaced apart from the first surface, and the plurality of teeth being structured such that rotation of any of the plurality of teeth causes corresponding rotation of all of the plurality of teeth.

US Pat. No. 10,508,410

AUTOMATIC VIBRATION DEVICE OF WORK MACHINE

Caterpillar SARL, Geneva...

1. An automatic vibration device for a work machine, the automatic vibration device comprising:a chassis;
a work device coupled to the chassis so that the work device may be operated relative to the chassis, the work device including a stick rotated by a stick cylinder, and a bucket coupled axially to a tip of the stick and rotated by a bucket cylinder;
a posture sensor configured to generate a posture signal that is indicative of a posture of the work device;
a weight sensor configured to generate a weight signal that is indicative of a weight of a load scooped into the bucket; and
a controller operatively coupled to the stick cylinder, the bucket cylinder, the posture sensor, and the weight sensor, the controller being configured to
effect an automatic vibration mode that causes the work device to vibrate automatically,
receive the posture signal from the posture sensor,
maintain the posture of the work device within a predetermined posture range while automatically vibrating the work device, based on the posture signal,
receive the weight signal from the weight sensor,
compare the weight of the load to a first weight threshold value, and
set an amplitude of an automatic vibration of the work device to a first amplitude value in response to the weight of the load being not less than the first weight threshold value.

US Pat. No. 10,508,409

MACHINE WITH A BOOM ASSEMBLY AND CONNECTION MEMBER

Caterpillar Inc., Peoria...

1. An excavator machine, comprisingan undercarriage assembly including a drive assembly;
a carriage assembly rotatably coupled to the undercarriage assembly and including an operator cab positioned at a front of the carriage assembly; and
a boom assembly,
wherein the boom assembly is coupled to the carriage assembly via two branches, and wherein the branches are coupled to the carriage assembly on opposing sides of the operator cab,
wherein the branches of the boom assembly are connected by a connection member,
wherein a boom extends from the connection member, and
wherein an attached end of the boom encapsulates a portion of the connection member.

US Pat. No. 10,508,408

ATTACHMENT SYSTEM FOR A WORK VEHICLE IMPLEMENT

CNH Industrial America LL...

1. An attachment system for a work vehicle implement, comprising:an implement attachment assembly, comprising:
a receiver assembly configured to couple to a connector assembly of an arm of a work vehicle; and
a support structure coupled to the receiver assembly, wherein the support structure comprises a first mounting feature configured to engage a first corresponding mounting feature extending downwardly from a bottom surface of the work vehicle, and a second mounting feature configured to engage a second corresponding mounting feature extending downwardly from the bottom surface of the work vehicle;
wherein the first and second mounting features of the support structure are spaced apart from one another along a longitudinal axis relative to a direction of travel of the work vehicle, and the first and second mounting features of the support structure are configured to substantially block horizontal and vertical movement of the support structure relative to the work vehicle via engagement with the first and second corresponding mounting features of the work vehicle.

US Pat. No. 10,508,404

BARRIER WALL AND METHOD AND SYSTEM OF MAKING A BARRIER WALL

DeWind One-Pass Trenching...

1. A barrier wall configured for formation and placement within a formed trench, the barrier wall formed from a plurality of wall segments, each wall segment comprising:a wall body including a front surface, a back surface, and an outer frame with a filler positioned therewithin, the outer frame further including a top surface, a bottom surface opposite the top surface, a tab side surface extending between the top surface and the bottom surface and a slot side surface extending between the top surface and the bottom surface opposite the tab side surface, to, in turn, define a rectangular cubic configuration, the filler comprising a concrete material;
a length coupling subassembly coupled to the wall body;
a width coupling subassembly coupled to the wall body,
a plurality of inner braces embedded within the filler, to, reinforce the same, and
a communication structure extending between the top surface and the bottom surface, the communication structure comprising a plurality of elongated tubes extending between the top surface and the bottom surface and further includes a manifold coupling a first end of a plurality of the plurality of elongated tubes, and an inlet providing ingress into the manifold;wherein, the plurality of wall segments can be attached to each other by joining at least one of the length coupling subassembly of one of the plurality of wall segments to another one of the plurality of wall segments, and the width coupling subassembly of one of the plurality of wall segments to another one of the plurality of wall segments.

US Pat. No. 10,508,401

DEPTH VIBRATOR WITH ADJUSTABLE IMBALANCE

1. A depth vibrator for compacting soil, comprising:a rotary drive having an axis of rotation;
a drive shaft rotatable about the axis of rotation of the rotary drive in a first rotation direction R1 and in second rotation direction R2 opposite R1;
a primary mass body fixed to the drive shaft and rotatable therewith about the axis of rotation;
a stop member fixed to the drive shaft; and
a secondary mass body orbital about the drive shaft between a first rotation position P1 relative to the primary mass body by rotation of drive shaft in said first rotation direction R1 until said secondary mass body abuts one side of said stop member, and a second rotation position P2 relative to the primary mass body by rotation of the drive shaft in the second rotation direction until said secondary mass body abuts an opposing side of said stop member.

US Pat. No. 10,508,400

TURF REINFORCEMENT MATS

Willacoochee Industrial F...

1. A turf reinforcement mat configured for placement on soil for erosion control, the turf reinforcement mat comprising spun yarn in at least one of a warp direction and a weft direction, wherein:the spun yarn comprises core-sheath spun yarn in one of the warp direction or the weft direction, but not both;
the turf reinforcement mat comprises polypropylene or polyethylene terephthalate monofilament yarn in the other one of the warp direction or the weft direction, the polypropylene or polyethylene terephthalate monofilament yarn having a round cross section;
the core-sheath spun yarn is interwoven with the polypropylene or polyethylene terephthalate monofilament yarn such that the turf reinforcement mat has a pyramidal weave; and
the core-sheath spun yarn comprises a polypropylene monofilament core having a round cross section and a polypropylene or polyester fiber sheath having a round cross section.

US Pat. No. 10,508,398

INSTALLATION GUIDE WITH QUICK RELEASE AND A METHOD THEREOF

Jitendra Prasad, Houston...

1. An installation guide with quick release for installation of a piece of equipment, the installation guide with quick release comprising:a base member adapted to be fixed at a predetermined location, the base member having a cavity;
an engagement member adapted to be received into the cavity of the base member;
a latching mechanism adapted to latch the engagement member with the base member, the latching mechanism including a release line attached with the engagement member; and
a guide line attached with the engagement member;
wherein the latching mechanism is adapted to release the engagement member from the base member on actuation of the release line;
wherein the engagement member includes an engagement cone;
wherein the latching mechanism is constituted by a stopper groove provided along an internal surface of the cavity and one or more latch pins provided with the engagement member, the one or more latch pins being adapted to be received in the stopper groove for latching the engagement member with the base member and adapted to be removed from the stopper groove when actuated by the release line; and
wherein the one or more latch pins are connected to the release line, through the one or more respective individual cords connecting the one or more respective latch pins with the release line.

US Pat. No. 10,508,396

WATER BARRIER ELEMENT

1. A water barrier for connection in a chain of water barriers, the water barrier comprising inclined supports and inclined barrier panels supported thereon, wherein the barrier panels are made of high tensile steel and are bent a distance down from a top edge of the barrier panels so that a top part of the barrier panels, when mounted on the inclined support, become more upright than a lower part of the barrier panels or even vertical, wherein the barrier panels are connected to the inclined supports by at least one keyhole opening close to each side edge of the lower part of the barrier panel and corresponding protrusions with enlarged knobs on the inclined supports, wherein the enlarged knobs are insertable into a larger part of the keyholes that is wider than a narrower part of the keyholes along which the protrusions are movable, wherein the protrusions have a length at least twice a thickness of the panels permitting adjoining proximate barrier panels to overlap and share protrusions and enlarged knobs, and wherein the inclined supports in their lower ends are U-shaped in order to grip over a lower edge portion of the barrier panels.

US Pat. No. 10,508,395

PAVEMENT SWEEPING APPARATUSES AND METHODS

1. A pavement sweeping apparatus for traversing pavement and substantially removing particulate milling particles from the pavement, comprising:a directionally mobile apparatus frame having a longitudinal midline axis;
at least one pickup unit carried by the apparatus frame, the at least one pickup unit having a first side and a second side and configured to form a pickup unit sweep path on the pavement;
at least one actuatable first side edge broom carried by the apparatus frame on the first side and forward of the at least one pickup unit;
at least one actuatable first side curb broom carried by the apparatus frame on the first side and forward of the at least one pickup unit;
at least one actuatable second side edge broom carried by the apparatus frame on the second side and forward of the at least one pickup unit;
at least one actuatable second side curb broom carried by the apparatus frame on the second side and forward of the at least one pickup unit;
at least one actuatable directing broom carried by the apparatus flame on the first side and forward of the at least, one pickup unit and configured to contact the pavement, the at least one actuatable first side edge broom and the at least one actuatable first side curb broom are disposed on a first side and forward of the at least one actuatable directing broom; and
the at least one actuatable directing broom having a longitudinal broom axis disposed at an acute directing broom angle to the longitudinal midline axis of the apparatus frame and configured to form a directing broom sweep path on the pavement, whereby the at least one actuatable directing broom is configured to sweep at least a portion of the particulate milling particles from the directing broom sweep path into the pickup unit sweep path of the at least one pickup unit.

US Pat. No. 10,508,394

DEVICE FOR VEHICLE HINDRANCE AND RAINWATER TREATMENT AND SYSTEM COMPRISING THE SAME

CHONGQING UNIVERSITY, Ch...

1. A device, comprising:1) a vehicle hindrance body comprising a lower sidewall, the lower sidewall comprising a plurality of water inlet holes;
2) a well pit, the well pit comprising a top opening, an upper part, a lower part, and a partition disposed between the upper part and the lower part;wherein:the lower sidewall encloses the top opening;
the partition comprises a plurality of leaking holes; the upper part communicates with the lower part through the leaking holes of the partition;
the upper part of the well pit comprises an outer ring belt filled with a rainwater pretreatment filler, a center ring belt filled with soil, and a rainwater collection ring belt disposed between the outer ring belt and the inner ring belt;
the rainwater collection ring belt comprises a top water inlet, and an elevation of the top water inlet is greater than an elevation of the rainwater pretreatment filler and an elevation of the soil; two side walls of the lower part of the rainwater collection ring belt are provided with equally spaced sandproof holes; and a sand-gravel cushion is disposed below the soil;
the lower part comprises a water-sand separating folded plate, a water-sand discharging channel, a rainwater collecting tank, and a rainwater storage chamber;
the rainwater collecting tank is disposed at an outer side of the water-sand discharging channel and between the water-sand discharging channel and the rainwater storage chamber; the water-sand separating folded plate is disposed below the leaking holes of the partition, and one end of the water-sand separating folded plate is fixed on a side wall of the lower part, the other end of the water-sand separating folded plate extends above the rainwater collecting tank;
the water-sand separating folded plate comprises a plurality of grooves and a plurality of sand discharging holes are disposed in the grooves at regular intervals; the water-sand discharging channel is disposed right below the sand discharging holes; and
the rainwater collecting tank and the rainwater storage chamber share a partition wall; a lower part of the partition wall comprises a through hole, and the rainwater collecting tank communicates with the rainwater storage chamber via the through hole.

US Pat. No. 10,508,393

PORTABLE VEHICLE BARRIER

1. A portable vehicle barrier to prevent passage of a vehicle, comprising:a main beam; and
a plurality of spar assemblies attached to the main beam, the plurality of spar assemblies being spaced apart along the main beam;
wherein each of the plurality of spar assemblies comprises a plurality of spars that are angularly spaced apart from one another and extend outwardly from the main beam;
wherein the main beam has a plurality of openings spaced apart along the main beam, and wherein each of the plurality of spar assemblies comprises a first spar and a second spar that extend through corresponding openings.

US Pat. No. 10,508,392

BRIDGE OVERHANG BRACKET ASSEMBLY WITH ADJUSTABLE SIDE MEMBER

1. A bridge overhang bracket assembly, comprising:a top member extending lengthwise between inner and outer ends;
a diagonal member extending lengthwise between lower and upper ends, the top and diagonal members being pivotally attached proximate to the respective outer and upper ends thereof;
a side member extending lengthwise between bottom and top ends, the top and side members being pivotally attached proximate to the respective inner and top ends thereof, the diagonal and side members being pivotally attached proximate to the respective lower and bottom ends thereof;
wherein the side member is configured so that its length between the bottom and top ends is adjustable;
wherein the side member comprises at least one strut;
wherein the at least one strut comprises upper and lower struts that are fastenable together in a plurality of longitudinal positions so that the length of the side member is adjustable;
wherein the upper and lower struts are each tubular members and one is received telescopically by the other; and
wherein the side member comprises a threaded member that is coupled to the at least one strut such that rotating the threaded member adjusts the length of the side member.

US Pat. No. 10,508,390

PLURAL-COMPONENT, COMPOSITE-MATERIAL HIGHWAY DOWEL BAR FABRICATION METHODOLOGY

Composite Rebar Technolog...

1. A plural-component, composite-material highway dowel bar comprisingan elongate, cylindrical, steel core having a long axis, and
an elongate, fibre-reinforced plastic-resin jacket covering the core, said jacket including
an elongate, cylindrically tubular sleeve which is fibre-reinforced in plural, plastic-resin-embedded, fibre-differentiated, circumferentially-adjacent circumferential layers of fibres.

US Pat. No. 10,508,385

CLOTH POSITIONER FOR CONTINUOUS PROCESSING

WHOLEKNIT INTERNATIONAL C...

1. A cloth positioner for continuous processing, comprising:a processing base;
an alignment plate provided on the processing base; and
at least one figure position abutment pin piece,
wherein the processing base includes a plurality of thru holes and the alignment plate includes at least one pin piece slot matching with the at least one figure position abutment pin piece, a plurality of air pressure vents, and at least one laser cutting line groove,
wherein the at least one figure position abutment pin piece comprises a body used for matching with and being loaded into the pin piece slot, and a clamping part used for connecting to the body and fixing the cloth, and
with the at least one figure position abutment pin piece that is provided for fixing a cloth onto the pin piece slot, the cloth is positioned on the cloth positioner for continuous processing.

US Pat. No. 10,508,384

TOP OF AN APPLIANCE FOR DRYING LAUNDRY PROVIDING DRYING AIR RECIRCULATION AND MOISTURE CONDENSATION

Electrolux Home Products ...

1. A top adapted to match and close from above a cabinet of a laundry drying appliance, the top being formed as a ready-to-mount part ready to be mounted to the cabinet, the top comprising lateral walls, an upper worktop surface, and a bottom surface and forming a moisture condensing module for dehydrating drying air used to dry laundry within a drying drum of the laundry drying appliance, the top having:a drying air inlet,
a drying air outlet,
fluid passageways defined thereinside from said drying air inlet to said drying air outlet for the passage of the drying air to be dehydrated, and
a moisture condenser arranged inside said fluid passageways,
wherein the moisture condenser comprises a heat pump evaporator fluidly coupled or couplable to a compressor body by means of a pipe, wherein an upper portion of said compressor body is attached to the bottom surface of the top below the upper worktop surface of the top, and a lower portion of the compressor body extends from the bottom surface of the top to a lower end of the compressor body, wherein the lower end of the compressor body hangs freely below the bottom surface; and
a heat pump condenser downstream of said heat pump evaporator.

US Pat. No. 10,508,383

CLOTHING TREATMENT DEVICE

Aqua Co., Ltd., (JP) Qin...

1. A clothing treatment device, comprising:a bag body configured to accommodate clothing;
an ozone supply part comprising an ozone generator and a blowing fan, wherein the ozone generator is configured to generate ozone, and the blowing fan is configured to deliver the ozone generated by the ozone generator into the bag body by airflow; and
a control part configured to perform a second operation which enables the blowing fan to operate intermittently after performing a first operation which enables the ozone generator and the blowing fan to operate.

US Pat. No. 10,508,380

WASHING MACHINE

SAMSUNG ELECTRONICS CO., ...

1. A washing machine comprising:a body;
a tub disposed inside the body;
a detergent containing unit including:
a housing,
a detergent container having a water supply hole to supply washing water to the detergent container, the detergent container housed in the housing to contain a detergent that mixes with the washing water in the detergent container and then moves along a path to be supplied to the tub, and
a rotary device rotatably coupled with at least part of the path to dissolve the detergent in the washing water; and
a nozzle device coupled with the water supply hole, the nozzle device comprising:
a nozzle in which at least one air inlet hole and a washing water inlet hole are formed to mix the washing water with air and supply the washing water mixed with the air to the detergent container,
a nozzle housing in which the nozzle is inserted, and
an elastic member inserted between the nozzle housing and the nozzle, the elastic member configured to press the nozzle depending on a pressure of the washing water, which flows into the nozzle, to guide the nozzle to move forward and backward.

US Pat. No. 10,508,379

HIGH TEMPERATURE DRYER DOOR SEALS AND RELATED METHODS

Felters of South Carolina...

1. A high temperature dryer door seal comprising:an outer substrate forming an interior cavity, the outer substrate being deformable upon compression and having a shape to provide a tight seal between a dryer door and a bulkhead of a dryer; and
a heat resistant coating disposed within the interior cavity of the outer substrate that expands at temperatures above an activation temperature, the outer substrate comprising a polymer that has a melting point below the activation temperature at which the heat resistant coating is activated.

US Pat. No. 10,508,378

VIBRATION-DAMPING COMPONENT OF WASHING MACHINE

QINGDAO HAIER WASHING MAC...

1. A vibration-damping component of a washing machine comprising a suspender, a spring, a sleeve and an electromagnetic sensing device,wherein the electromagnetic sensing device comprises an electromagnetic coil and a magnet,
the electromagnetic coil fixedly sleeves on an outer side of the sleeve,
the magnet is arranged in the sleeve and is relatively fixed on the suspender,
the sleeve sleeves on the suspender in a slidable manner,
the spring is arranged between the sleeve and the magnet,
and a weight of clothing is determined through measuring an inductance change of the electromagnetic coil when the sleeve slides on the suspender under stress,
a base is fixedly arranged at a lower end of the suspender, the base supports the spring and the magnet,
the vibration-damping component further comprising a sliding cup, the sliding cup is arranged between the base and the magnet,
the sliding cup is annular and sleeves on the suspender, and
a diameter of the sliding cup is matched with an inside diameter of the sleeve.

US Pat. No. 10,508,377

LAUNDRY TREATING APPLIANCE WITH AN ADJUSTABLE HEIGHT LIFTER

Whirlpool Corporation, B...

1. A laundry treating appliance comprising:a drum having an inner surface at least partially defining a treating chamber and an end with an opening to define an access opening to the treating chamber; and
a lifter extending from the inner surface inwardly into the treating chamber and having an adjustable element rotatably mounted to the lifter and rotating between first and second positions, the adjustable element having first and second profiles and a maximum projection;
wherein when the adjustable element is in the first position, the first profile provides the lifter with a first effective height defined by the maximum projection, and when the adjustable element is in the second position, the second profile provides the lifter with a second effective height, which is less than the first effective height, and further wherein the maximum projection is at least one of flush with a sidewall of the lifter or received within an interior of the lifter when the adjustable element is in the second position.

US Pat. No. 10,508,376

WASHING MACHINE

Haier Asia Co., Ltd., Sh...

1. A washing machine, comprising:a washing/dewatering drum, configured to accommodate washings and capable of rotating;
an electric motor for driving the washing/dewatering drum to rotate; and
an execution unit, configured to supply water to the washing/dewatering drum, execute drainage of the washing/dewatering drum, and control rotation of the electric motor to drive the washing/dewatering drum to rotate, and execute a washing operation consisting of a washing process, a rinsing process after the washing process and a dewatering process, wherein
the dewatering process comprises a final dewatering process and an intermediate dewatering process, wherein the final dewatering process is executed at the end of the washing operation, and the intermediate dewatering process is at least executed immediately after the washing process;
in the rinsing process of the washing operation in a water saving mode, the execution unit is configured to continuously execute a dewatering-rinsing process for a plurality of times rather than executing a water-storage rinsing process for rinsing the washings while water stored in the washing/dewatering drum reaches a specified water level, wherein the dewatering-rinsing process comprises: a water supplying process of supplying water to the washing/dewatering drum so that the washings are saturated by water, and the intermediate dewatering process or the final dewatering process executed immediately after the water supplying process; and
a maximum rotating speed of the electric motor in the intermediate dewatering process immediately before the water supplying process is lower than a maximum rotating speed of the electric motor in the final dewatering process;
wherein the execution unit is configured to drive the washing/dewatering drum to rotate intermittently in the water supplying process, and configured to intermittently supply water to the washing/dewatering drum in the water supplying process.

US Pat. No. 10,508,375

METHOD FOR OPERATING A WASHING APPLIANCE AND WASHING APPLIANCE

Electrolux Appliances Akt...

1. A method for operating a laundry washing appliance having a washing chamber to wash goods, said method including:selecting a default washing temperature or a washing program having a default washing temperature;
supplying a detergent to the washing chamber;
detecting, by a sensor, a physical property of the detergent;
determining a type of said detergent which has been added based on the physical property of the detergent detected by the sensor;wherein, in case said detergent is determined to be a first type including a deterrent in liquid or gel form, the method includes:comparing said default washing temperature with a threshold temperature; and
when said default washing temperature is higher than said threshold temperature, emitting a warning signal or changing said default washing temperature.

US Pat. No. 10,508,374

METHOD FOR OPERATING A LAUNDRY WASHING APPLIANCE AND LAUNDRY WASHING APPLIANCE IMPLEMENTING THE SAME

Electrolux Appliances Akt...

1. A method for operating a laundry washing appliance comprising a washing chamber to wash goods according to a wash program selected by a user including at least a washing cycle, said method including:adding a detergent to a washing liquor within the washing chamber during a washing phase of the washing cycle, the washing phase having a predefined duration;
performing a plurality of measurements of the conductivity of the washing liquor in order to collect a set of conductivity measurements defining a conductivity curve;
analyzing the set of conductivity measurements in order to determine when a steady condition of the conductivity measurements is reached and/or detect when the related conductivity curve shows a peak;
extending the predefined duration of the washing phase, when during a first preset time period starting from the beginning of the washing phase, it is determined that no conductivity increase or peak in the conductivity curve is detected; and
extending the predefined duration of the washing phase, when after a second preset time period starting from the beginning of the washing phase and ending after the first preset time period, it is determined that the steady condition of the conductivity measurements has not been reached.

US Pat. No. 10,508,373

EMBROIDERED ARTICLE

NIKE, Inc., Beaverton, O...

1. An article, the article comprising:a base layer; and
a first strand embroidered with the base layer,
wherein the first strand is embroidered with the base layer at a first embroidered area,
wherein at least one of the first strand and a second strand are embroidered with the base layer at a second embroidered area,
wherein the first embroidered area has a first degree of a mechanical property,
wherein the second embroidered area has a second degree of the mechanical property that is different than the first degree of the mechanical property, and
wherein the base layer includes at least one yarn, and wherein the at least one yarn includes a thermoplastic polymer material.

US Pat. No. 10,508,371

THREAD AND NEEDLE PROTECTOR

1. A thread and needle protector for protecting a needle carrying a length of thread, wherein the needle is configured with a needle tip at a front end thereof and a thread reception eye at the rear end thereof and carrying said length of thread, the protector comprising:a carrier body having front and rear ends and a side periphery configured as a longitudinally elongated shell extending between the front and rear ends of the carrier body, wherein the front end of said shell receives said needle tip;
a needle reception material located within the shell behind the front end thereof for, in use, retaining the received needle tip of said needle engaged in the front end of the shell;
a front transverse flange extending laterally outwardly from the front end of the shell;
a rear transverse flange extending laterally outwardly from the rear end of the shell;
wherein said front and rear transverse flanges define an interflange gap between them;
the front transverse flange defines a slot open at the periphery of the front transverse flange
wherein said length of thread extends from the needle eye of the needle engaged in the shell, through said slot and into said interflange gap, whereby winding the thread on the side of the slot facing the interflange gap is localized from winding the thread on the side of the slot facing the needle eye;
and further comprising:
an open-topped container body defining a well; and
a pair of spaced apart supports mounted within the container body near the open top thereof and partially closing the open top, wherein the spacing between the supports is sufficiently wide to pass a length of needle into said well, and the spacing between the supports is sufficiently narrow to prevent passage of said front transverse flange, such that said interflange gap is supported at least partially above the open topped container body, visually displaying any thread on said shell within the interflange gap.

US Pat. No. 10,508,364

RF RESONATOR MEMBRANES AND METHODS OF CONSTRUCTION

Zhuhai Crystal Resonance ...

1. A single crystal film comprising BaxSr(1-x)TiO3 having an <111> orientation coupled to a c-axis <0001> sapphire membrane by a <0001> GaN release layer and further comprising a <100> rutile TiO2 and/or a <111> Sr(1-x)TiO3 buffer layer between the GaN and the BaxSr(1-x)TiO3.

US Pat. No. 10,508,363

VAPOR PHASE GROWTH APPARATUS HAVING SUBSTRATE HOLDER WITH RING-SHAPED PROTRUSION

NuFlare Technology, Inc.,...

1. A vapor phase growth apparatus comprising:a reaction chamber;
a ring-shaped holder provided in the reaction chamber, the ring-shaped holder configured to hold a substrate, the ring-shaped holder including an outer portion, and an inner portion on which a ring-shaped protrusion is provided and surrounded by the outer portion, the ring-shaped protrusion being separated from the outer portion, an upper surface of the outer portion being higher than an upper surface of the ring-shaped protrusion, the upper surface of the ring-shaped protrusion being a flat surface, the ring-shaped holder having an opening portion at a center of the ring-shaped holder, a maximum distance between an inner end of the outer portion which is closest to the center of the ring-shaped holder and an outer end of the ring-shaped protrusion which is on a diametrically opposite side of the ring-shaped holder being equal to or smaller than a diameter of the substrate; and
a heater provided below the ring-shaped holder, no component being provided between the heater and a center portion of the substrate,
wherein a diameter of the opening portion is equal to or greater than 90% of a diameter of the substrate, and
wherein an upper part of an inner surface of the outer portion protrudes inward from a lower part of the inner surface of the outer portion and a concave recess having a height greater than the height of the upper surface of the ring-shaped protrusion, but less than the height of the upper surface of the outer portion is formed.

US Pat. No. 10,508,362

SUBSTRATE MOUNTING MEMBER, WAFER PLATE, AND SIC EPITAXIAL SUBSTRATE MANUFACTURING METHOD

Mitsubishi Electric Corpo...

1. A substrate mounting member for mounting a SiC substrate for epitaxial growth, comprising:a wafer plate including a member having a SiC polycrystal coat covering said member, said member having a counterbore with said SiC polycrystal coat extending along a side wall of said member defining said counterbore and along a surface of said member defining a bottom surface of said counterbore; and
a supporting plate having a size in relation to a size of said counterbore in plan view of said member such that said supporting plate is configured to be placed directly on said SiC polycrystal coat that extends along said bottom surface of said counterbore, said supporting plate including no SiC polycrystal and having a surface serving as a SiC substrate placing surface onto which said SiC substrate that is received into said counterbore is directly placed, the surface being on the side opposite to a surface in contact with said SiC polycrystal coat that extends along said bottom surface of said counterbore,
wherein a thickness h [mm] of said supporting plate is 0.08 mm or less and satisfies an expression h4?3 pa4(1?v2){(5+v)/(1+v)}/16E when a force applied to a unit area of said supporting plate by a self-weight of said supporting plate and by said SiC substrate placed directly on said SiC substrate placing surface is represented as p [N/mm2], a radius of said supporting plate as a [mm], a Poisson's ratio as v and a Young's modulus as E [MPa].

US Pat. No. 10,508,361

METHOD FOR MANUFACTURING SEMICONDUCTOR WAFER

KWANSEI GAKUIN EDUCATIONA...

1. A method for manufacturing a semiconductor wafer, the method comprising:a first step of forming protrusions on a surface of an SiC substrate and heating the SiC substrate under Si vapor pressure, to etch the SiC substrate;
a second step of arranging a carbon feed member on the protrusion side of the SiC substrate after the first step with an Si melt interposed therebetween, then heating so that the protrusions of the SiC substrate are epitaxially grown to form epitaxial layers through metastable solvent epitaxy process, the epitaxial growth allowing an epitaxial layer containing threading screw dislocation to be more largely grown in a vertical (c-axis) direction as compared with an epitaxial layer containing no threading screw dislocation, and then removing at least a part of the epitaxial layer containing threading screw dislocation; and
a third step of performing metastable solvent epitaxy process again on the SiC substrate after the second step, to cause epitaxial layers containing no threading screw dislocation to be grown in a horizontal (a-axis) direction to be connected at a molecular level, so that at least one monocrystalline 4H—SiC semiconductor wafer having a large area is generated on an Si-face (0001 face) or a C-face (000-1 face) which is a surface of the SiC substrate.

US Pat. No. 10,508,360

MULTIFUNCTIONAL NANOCELLULAR SINGLE CRYSTAL NICKEL FOR TURBINE APPLICATIONS

United Technologies Corpo...

1. A process for manufacturing a nanocellular single crystal based material comprising steps of:providing a first solution containing a nickel precursor in deionized water;
providing a second solution containing a structure controlling polymer or a surfactant and an alcohol;
mixing said first and second solutions into a solution containing a reducing agent to form a third solution; and processing said third solution to create the nanocellular single crystal based material; wherein said processing comprises stirring said third solution at a temperature in a range of 100° C. to 130° C. for a time period in a range of 5.0 minutes to 15 minutes;
removing sol from said stirred third solution and then centrifuging said third solution at a speed of 2000 rpm to 5000 rpm for a time in a range of 5.0 min. to 15 min;
removing sol from said centrifuged third solution and leaving a product of the nanocellular single crystal based material;
washing said nanocellular single crystal based material in a washing solution containing an alcohol and deionized water to remove soluble inorganic salts and organic solvents from the nanocellular single crystal based material, subjecting the washing solution to sonication for a time period in the range of 5.0 to 15 min., and then performing a filtration step to remove the washing solution from the nanocellular single crystal based material; wherein the nanocellular single crystal based material comprises pores and ligaments in the range of 0.05 to 100 microns.

US Pat. No. 10,508,358

PROCESS FOR FORMING A TRANSITION ZONE TERMINATED SUPERCONFORMAL FILLING

GOVERNMENT OF THE UNITED ...

1. A process for forming a transition zone terminated superconformal filling in a recess of a substrate by electrodepositing metal, the process comprising:providing an electrodeposition composition comprising:
a metal electrolyte comprising a plurality of metal ions and a solvent; and
a suppressor disposed in the solvent;
providing the substrate comprising:
a field surface; and
the recess disposed in the substrate, the recess comprising a distal position and a proximate position relative to the field surface of the substrate;
exposing the recess to the electrodeposition composition;
potentiodynamically controlling an electric potential of the recess with a potential wave form;
bifurcating the recess into an active metal deposition region and a passive region in response to potentiodynamically controlling the electric potential;
forming, in response to bifurcating the recess, a transition zone at an interface of the active metal deposition region and the passive region;
decreasing the electric potential of the recess by the potential wave form;
progressively moving the transition zone closer to the field surface and away from the distal position in response to decreasing the electric potential; and
reducing the metal ions to form metal and depositing the metal in the active metal deposition region and not in the passive region to form the transition zone terminated superconformal filling in the recess of the substrate, the transition zone terminated superconformal filling being:
void-free,
disposed in the recess in the active metal deposition region from the distal position to the transition zone,
comprising a v-notch, and
absent in the passive region between the proximate position and the transition zone,
wherein the electrodeposition composition has an S-shaped negative differential resistance cyclic voltammogram.

US Pat. No. 10,508,357

METHOD OF FILLING THROUGH-HOLES TO REDUCE VOIDS AND OTHER DEFECTS

Rohm and Haas Electronic ...

1. A method comprising:a) providing a printed circuit board with a plurality of through-holes comprising a layer of electroless copper, copper flash or combinations thereof on a surface of the printed circuit board and walls of the plurality of through-holes, wherein the through-holes have diameters of 75-125 ?m and wherein the printed circuit board is 200 ?m to 300 ?m thick;
b) immersing the printed circuit board in a copper electroplating bath comprising an anode; and
c) filling the through-holes with copper by a direct current cycle consisting of applying direct current and a first current density for a first predetermined period of time, wherein the first current density ranges from 1 ASD to 5 ASD, followed by turning off the direct current and the first current density for a second predetermined period of time, wherein the second predetermined period of time is from 0.5 minutes to 10 minutes, and then turning on the direct current and applying a lower second current density for a third predetermined period of time, wherein the lower second current density ranges from 0.5 ASD to 3 ASD and wherein the first current density is higher than the lower second current density and the first predetermined period of time is shorter than the third predetermined period of time in the direct current cycle.

US Pat. No. 10,508,356

ELECTRO-PLATING AND APPARATUS FOR PERFORMING THE SAME

Taiwan Semiconductor Manu...

1. A method comprising:plating a wafer using an apparatus, the apparatus comprising:
a first electrical contact;
a first power supply source electrically connected to the first electrical contact, wherein the first power supply source is configured to supply a first voltage to the first electrical contact;
a retractable electrode comprising:
an outer shell;
a second electrical contact comprising a first portion extending into the outer shell and a second portion extending out of the outer shell; and
a seal ring encircling the first portion of the second electrical contact, wherein the seal ring is formed of a flexible material, wherein the seal ring and the second electrical contact are configured to move relative to the outer shell;
a second power supply source electrically connected to the second electrical contact, wherein the second power supply source is configured to supply a second voltage different from the first voltage to the second electrical contact;
contacting the first electrical contact to an edge portion of the wafer;
contacting the second electrical contact to an inner portion of the wafer, wherein the first electrical contact and the second electrical contact are spaced apart from each other by about a radius of the wafer; and
plating the wafer, wherein during the plating, the first power supply source and the second power supply source supply the first voltage and the second voltage to the first electrical contact and the second electrical contact, respectively.

US Pat. No. 10,508,355

PLATING APPARATUS

EBARA CORPORATION, Tokyo...

1. A plating apparatus comprising:a processing section configured to plate a substrate;
a storage container configured to store a substrate holder, the substrate holder configured to hold the substrate;
a transport machine configured to transport the substrate holder between the processing section and the storage container;
a maintenance area adjacent to the storage container;
a frame provided in the maintenance area, the frame being adjacent to the transport machine, and the frame having a size that allows maintenance of the substrate holder to be conducted in the maintenance area;
a substrate-holder carrier supported by the storage container, the substrate-holder carrier being movable between the storage container and the maintenance area while supporting the substrate holder that needs maintenance during an operation of the transport machine;
a pedestal configured to partition an inside portion of the plating apparatus from an outside portion,
wherein the processing section, the storage container, the maintenance area, and the substrate-holder carrier are disposed in the inside portion of the plating apparatus, and
wherein the processing section, the storage container, and the transport machine are disposed outside the frame.

US Pat. No. 10,508,354

FEEDER CAPABLE OF FEEDING ANODE AND PLATING APPARATUS

EBARA CORPORATION, Tokyo...

1. A feeder capable of feeding an anode for use in plating a substrate, the feeder comprising:a main body portion which is configured to be disposed on substantially an entire periphery of an outer periphery of the anode;
a spring which is disposed in the main body portion and configured to apply a first force to the main body portion in a direction from the main body portion toward a region surrounded by the main body portion; and
a fastening portion which is configured to dispose the spring in at least one of two end portions of the main body portion in an outer peripheral direction of the region,
wherein the two end portions extend in a direction away from the region,
the fastening portion comprises two end portions and a shaft which connects the two end portions of the fastening portion,
the shaft passes through the spring and the two end portions of the main body portion,
the spring and the two end portions of the main body portion are disposed between the two end portions of the fastening portion,
the spring are not disposed between the two end portions of the main body portion, and
the spring is configured to apply a second force to the two end portions of the main body portion to bring the two end portions of the main body portion close to each other so as to apply the first force to the main body portion,
wherein the feeder comprises a conductor which can be disposed on an outer periphery of the anode, and the conductor is a belt-shaped band, wherein the main body portion can be disposed on substantially an entire periphery of an outer periphery of the conductor.

US Pat. No. 10,508,353

PHOTODEFINED APERTURE PLATE AND METHOD FOR PRODUCING THE SAME

STAMFORD DEVICES LIMITED,...

1. A nebulizer aperture plate for use in aerosolising a liquid in a nebulizer, comprising:a first material having a plurality of first apertures; and
a second material above the first material, the second material having a plurality of second apertures above the plurality of first apertures in the first material, wherein the plurality of second apertures define generally cylindrical shapes defining liquid supply cavities;
wherein at least one of the first material or the second material includes a characteristic of being formed through a photolithography process;
wherein at least some of the plurality of first apertures are within the diameter of the liquid supply cavity defined by one of the second apertures; and
wherein the first material and the second material collectively form a dome-shaped aperture plate.

US Pat. No. 10,508,352

METHOD AND APPARATUS FOR PROCESSING A SUBSTRATE

EBARA Corporation, Tokyo...

1. A method of processing a surface of a substrate while holding the substrate with a substrate holder including a first holding member and a second holding member, the second holding member having an opening, said method comprising:holding the substrate with the substrate holder by sandwiching the substrate between the first holding member and the second holding member, with the surface of the substrate being exposed through the opening of the second holding member, and pressing a sealing ridge of the substrate holder against a peripheral portion of the substrate to form an internal space in the substrate holder;
pressing a sealing block against the substrate holder to cover the sealing ridge, to form an external space defined by the substrate holder, the exposed surface of the substrate, and the sealing block;
forming a vacuum in the external space to create a pressure difference between the internal space and the external space;
performing a seal inspection to check a sealed state provided by the sealing ridge based on a change in pressure in the external space; and
performing a pre-wetting treatment by supplying a pre-wetting liquid to the external space while evacuating air from the external space to bring the pre-wetting liquid into contact with the exposed surface of the substrate.

US Pat. No. 10,508,349

METHOD OF ELECTROPLATING PHOTORESIST DEFINED FEATURES FROM COPPER ELECTROPLATING BATHS CONTAINING REACTION PRODUCTS OF PYRAZOLE COMPOUNDS AND BISEPOXIDES

Rohm and Haas Electronic ...

1. A method comprising:a) providing a substrate comprising a layer of photoresist, wherein the layer of photoresist comprises a plurality of apertures;
b) providing a copper electroplating bath comprising one or more sources of copper ions; 0.25 ppm to 1000 ppm of one or more reaction products of one or more pyrazole compounds, wherein the one or more pyrazole compounds have a formula:

where R1, R2 and R3 are independently chosen from hydrogen, linear or branched (C1-C10)alkyl and one or more bisepoxides, wherein the one or more bisepoxides are chosen from compounds having formula:

wherein R4 and R5 are hydrogen; R6 and R7 may be the same of different and are chosen from hydrogen, methyl and hydroxyl; m=1-6 and n=1-20; an electrolyte; one or more accelerators; and one or more suppressors, wherein a pH of the electrolyte is less than or equal to 2;
c) immersing the substrate comprising the layer of photoresist with the plurality of apertures in the copper electroplating bath; and
d) electroplating a plurality of copper photoresist defined features in the plurality of apertures at a current density of 0.25 ASD to 40 ASD, to provide the plurality of photoresist defined features with an average % TIR of 0% to 10% and a % WID of the plurality of photoresist defined features is from 0% to 10%.

US Pat. No. 10,508,348

ENVIRONMENTALLY FRIENDLY NICKEL ELECTROPLATING COMPOSITIONS AND METHODS

Rohm and Haas Electronic ...

1. A nickel electroplating composition comprising one or more sources of nickel ions, one or more sources of carboxylate ions, and 2-phenyl-5-benzimidazole sulfonic acid, salts thereof or mixtures thereof.

US Pat. No. 10,508,346

PATTERN OF A FILM LAYER INCLUDING ALUMINUM, AND MANUFACTURING METHOD AND AFTERTREATMENT METHOD THEREOF

BOE TECHNOLOGY GROUP CO.,...

1. An aftertreatment method for a dry etching process of a pattern of a film layer comprising aluminum, the method comprising:performing dechlorination treatment on a patterned film layer, comprising aluminum, of a substrate, and uninstalling the substrate from a bearing substrate simultaneously, wherein the patterned film layer is formed by a dry etching process using a gas comprising Cl2;
wherein performing the dechlorination treatment comprises:
introducing a gas mixture comprising O2 and CF4 for the dechlorination treatment; wherein in the introduced gas mixture comprising O2 and CF4, a gas volume flow ratio of O2 and CF4 is 30:1; and
wherein uninstalling the substrate from the bearing substrate comprises:
loading a voltage of 6 kV to 15 kV to generate plasma to remove static electricity which adsorbs the bearing substrate.

US Pat. No. 10,508,343

ETCHING METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE

FUJITSU LIMITED, Kawasak...

1. An etching device comprising:a radiation source to apply a radiation to an etching aqueous solution;
an etching bath to hold the etching aqueous solution to be irradiated with the radiation from the radiation source provided outside the etching bath through a radiation window provided at an upper portion of the etching bath;
a first catalyst layer being different from the etching aqueous solution and provided in the etching bath in such a manner that a first surface of the first catalyst layer is in contact with an inner surface of the radiation window and a second surface of the first catalyst layer opposite to the first surface is exposed to the etching aqueous solution in the etching bath; and
a second catalyst layer disposed at an inner sidewall and an inner bottom of the etching bath,
wherein the first catalyst layer is made of titanium oxide (TiO2), the radiation window is made of an insulating material which transmits the radiation, and the radiation is irradiated to an outer surface of the radiation window which is opposite to the inner surface of the radiation window with which the first catalyst is in contact.

US Pat. No. 10,508,342

METHOD FOR MANUFACTURING DIAMOND-LIKE CARBON FILM

CREATING NANO TECHNOLOGIE...

1. A method for manufacturing a diamond-like carbon film, comprising:disposing a substrate into a chamber;
applying a bias voltage to the substrate;
introducing a reaction precursor into the chamber, wherein the reaction precursor is consisting of aromatic cyclic hydrocarbon; and
growing a diamond-like carbon film on the substrate in the chamber when the gas environment of the chamber consists only of consist of the reaction precursor, wherein growing the diamond-like carbon film comprises controlling a substrate temperature at a range from 200 degrees centigrade to 800 degrees centigrade.

US Pat. No. 10,508,341

APPARATUS AND METHODS FOR PULSED PHOTO-EXCITED DEPOSITION AND ETCH

APPLIED MATERIALS, INC., ...

1. A substrate processing system, comprising:a processing chamber having a substrate support disposed therein;
a gas supply coupled to the processing chamber;
a thermal heating source disposed above the substrate support;
a laser source disposed adjacent to a sidewall of the processing chamber between the thermal heating source and the substrate support; and
a controller employing computer program code configured to control the substrate processing system to perform operations of:
providing, from the gas supply, a precursor gas mixture comprising a deposition precursor gas and an etch precursor gas;
selecting thermal energy from the thermal heating source to cause thermal decomposition of the deposition precursor gas, wherein the thermal energy alone is below a minimum energy required for pyrolysis of the etch precursor gas in the precursor gas mixture;
subjecting the precursor gas mixture to the thermal energy from the thermal heating source to deposit a material; and
after depositing the material, emitting, from the laser source, laser energy at a wavelength and power level selected to activate molecules in the etch precursor gas of the precursor gas mixture, the laser energy and the thermal energy together resulting in at least photolytic dissociation of the etch precursor gas occurring faster than decomposition of the deposition precursor gas to etch a portion of the material.

US Pat. No. 10,508,340

ATMOSPHERIC LID WITH RIGID PLATE FOR CAROUSEL PROCESSING CHAMBERS

Applied Materials, Inc., ...

19. A processing chamber comprising:a chamber body including a bottom wall and a sidewall with a ledge;
a susceptor assembly in the chamber body to support and rotate a plurality of substrates around a central axis, the susceptor assembly having a top surface;
an injector assembly positioned above the susceptor assembly and having a back surface and a front surface facing the top surface of the susceptor assembly and defining a process volume, an outer peripheral edge of the injector assembly supporting the injector assembly on the ledge of the sidewall of the chamber body, the injector assembly having a plurality of pegs at an outer peripheral edge extending from the front surface, the plurality of pegs positioned on the ledge of the sidewall to support the injector assembly;
a chamber lid comprising a top wall and sidewall, the sidewall connectable to the chamber body sidewall, the back surface of the injector assembly and the chamber lid top wall and sidewall enclosing a lid volume, the lid volume in fluid communication with the process volume so that both the lid volume and the process volume have about the same pressure during processing; and
a vacuum source in fluid communication with the process volume to lower the pressure in the process volume,
wherein a gap between the injector assembly and the susceptor assembly remains substantially the same at temperatures up to about 550° C.

US Pat. No. 10,508,336

SUBSTRATE PROCESSING APPARATUS

KOKUSAI ELECTRIC CORPORAT...

1. A substrate processing apparatus comprising:a substrate retainer configured to support a substrate;
a heat-insulating unit disposed under the substrate retainer;
a transfer chamber where the substrate is loaded into the substrate retainer;
a process chamber in which the substrate supported by the substrate retainer is accommodated and processed;
a seal cap configured to close a lower end of the process chamber;
an elevating mechanism configured to move the seal cap;
an arm connecting the seal cap to the elevating mechanism;
a gas supply mechanism configured to supply a gas into the transfer chamber, the gas supply mechanism comprising: a first gas supply mechanism configured to supply the gas into an upper region of the transfer chamber, where the substrate retainer is disposed such that the gas flows horizontally through the upper region; and a second gas supply mechanism configured to supply the gas into a lower region of the transfer chamber, where the heat-insulating unit is provided such that the gas flows downward through the lower region; and
a boundary plate disposed at a boundary between the upper region and the lower region in the transfer chamber to divide the transfer chamber into the upper region and the lower region,
wherein the first gas supply mechanism and the second gas supply mechanism are disposed along a first sidewall of the transfer chamber, and the second gas supply mechanism is disposed lower than the first gas supply mechanism,
wherein the boundary plate comprises an opening having a diameter greater than a diameter of the seal cap; a first cutaway portion wider than the arm to pass the arm therethrough; and a second cutaway portion wider than a substrate transfer device for transferring the substrate into the substrate retainer without colliding with the boundary plate.

US Pat. No. 10,508,333

HEATING APPARATUS AND SUBSTRATE PROCESSING APPARATUS HAVING THE SAME

Samsung Electronics Co., ...

1. A heating apparatus, comprising:a side wall heat insulator configured to provide an inner space for receiving a reaction tube;
an upper wall heat insulator covering a top portion of the side wall heat insulator;
a heat generation part in an inner surface of the side wall heat insulator; and
a heat compensating part on a lower surface of the upper wall heat insulator, the heat compensating part including a reflection surface in a first region on the lower surface of the upper wall heat insulator, the first region having a first emissivity less than an emissivity of the upper wall heat insulator,
wherein the heat compensating part further comprises an absorption surface in a second region on the lower surface of the upper wall heat insulator, the second region having a second emissivity greater than the first emissivity.

US Pat. No. 10,508,330

QUASICRYSTAL-CONTAINING PLATED STEEL SHEET AND METHOD FOR PRODUCING QUASICRYSTAL-CONTAINING PLATED STEEL SHEET

NIPPON STEEL CORPORATION,...

1. A quasicrystal-containing plated steel sheet comprising:a plating layer positioned on at least one surface of a steel sheet; and
an alloy layer positioned at an interface between the plating layer and the steel sheet and composed of an Al—Fe intermetallic compound,
wherein a chemical composition of the plating layer contains, in atom %,
Zn: 28.5% to 50%,
Al: 0.3% to 12%,
La: 0% to 3.5%,
Ce: 0% to 3.5%,
Y: 0% to 3.5%,
Ca: 0% to 3.5%,
Sr: 0% to 0.5%,
Si: 0% to 0.5%,
Ti: 0% to 0.5%,
Cr: 0% to 0.5%,
Fe: 0% to 2%,
Co: 0% to 0.5%,
Ni: 0% to 0.5%,
V: 0% to 0.5%,
Nb: 0% to 0.5%,
Cu: 0% to 0.5%,
Sn: 0% to 0.5%,
Mn: 0% to 0.2%,
Sb: 0% to 0.5%,
Pb: 0% to 0.5%, and
the balance: Mg and impurities, and
the plating layer includes, in order from the steel sheet side,
a first plating layer which is composed of a structure containing an MgZn phase, an Mg phase, and a quasicrystal phase, and
a second plating layer which is positioned on the first plating layer and is composed of a structure containing an Mg51Zn20 phase, a Zn phase, and a quasicrystal phase.

US Pat. No. 10,508,328

RAPID HEATING OF SHEET METAL BLANKS FOR STAMPING

NOVELIS INC., Atlanta, G...

1. A method comprising:receiving a blank of a metal substrate at a heater, wherein the heater comprises a magnetic rotor, and wherein the heater is upstream from a first hot forming press of a hot forming system;
positioning the blank adjacent the magnetic rotor of the heater and in a non-contacting configuration with the magnetic rotor;
rotating the magnetic rotor to induce a magnetic field in the blank to heat the blank for a predetermined time period;
removing the blank from the heater after the predetermined time period and moving the blank to the first hot forming press; and
shaping the blank into a predetermined shape with the first hot forming press.

US Pat. No. 10,508,327

MOLD STEEL AND MOLD

DAIDO STEEL CO., LTD., A...

1. A mold steel having a composition comprising, in terms of mass %:0.220%?C?0.360%;
0.65%?Si<1.05%;
0.43%?Mn?0.92%;
0.43%?Ni?0.92%;
0.67%?Mn+Ni?1.30%;
10.50%?Cr<12.50%;
0.05%?Mo<0.50%;
0.002%?V<0.50%;
0.001%?N?0.048%; and
0.300%?C+N?0.420%,
with the remainder being Fe and unavoidable impurities.

US Pat. No. 10,508,323

METHOD AND APPARATUS FOR SECURING BODIES USING SHAPE MEMORY MATERIALS

Baker Hughes, a GE compan...

1. A tool for forming or servicing a wellbore, comprising:a first body defining a first tapered surface;
a second body at least partially within the first body and defining a second tapered surface abutting the first tapered surface of the first body; and
a retaining member located between another surface of the first body and another surface of the second body,
wherein the retaining member comprises a shape memory material configured to transform, responsive to application of a stimulus, from a first solid phase to a second solid phase,
wherein the retaining member is configured not to interfere with the second body with respect to the first body when the shape memory material is in the first solid phase, and
wherein the retaining member at least partially retains the second body with respect to the first body when the shape member material is in the second solid phase.

US Pat. No. 10,508,316

METHOD AND FIXTURE FOR COUNTERACTING TENSILE STRESS

GENERAL ELECTRIC COMPANY,...

1. A method for counteracting tensile stress in an article, comprising:contacting a first compression member of a fixture having a first compressive surface including a first mating conformation to a first surface of the article;
contacting a second compression member of the fixture having a second compressive surface including a second mating conformation to a second surface of the article;
reversibly locking a first position lock of the fixture connecting the first compression member to the second compression member, fixing the first compression member relative to the second compression member, the first position lock including a first material composition;
heating the article within a furnace; and
applying compressive stress to the article along a compressive stress vector, the compressive stress vector including a compressive stress vector component opposite in direction to a tensile stress vector of a thermally-induced tensile stress of the article,
wherein the compressive stress is applied by thermally-induced autogenous pressure applied by the fixture contacting the article, and
wherein the first material composition includes at least one of:
a first phase transformation from body-centered cubic to face-centered cubic, the first material composition undergoing the first phase transformation during the heating, the first phase transformation contracting the first position lock and applying the compressive stress to the article; or
lower thermal expansion coefficient than the article, the first material composition expanding less than the article during the heating, applying the compressive stress to the article.

US Pat. No. 10,508,314

METHODS AND SYSTEMS FOR INCREASING THE CARBON CONTENT OF SPONGE IRON IN A REDUCTION FURNACE

Midrex Technologies, Inc....

1. A method for producing direct reduced iron having increased carbon content, comprising:providing a carbon monoxide-rich gas stream; and
delivering the carbon monoxide-rich gas stream to a direct reduction furnace and exposing partially or completely reduced iron oxide to the carbon monoxide-rich gas stream to increase the carbon content of resulting direct reduced iron;
wherein providing the carbon monoxide-rich gas stream comprises initially providing one of a reformed gas stream from a reformer and a syngas stream from a syngas source;
wherein the carbon monoxide-rich gas stream is derived from a carbon monoxide recovery unit that forms a portion of the carbon monoxide-rich gas stream and an effluent gas stream; and
wherein the carbon monoxide recovery unit is operated in parallel with a bypass line from which no effluent gas stream is removed, the carbon monoxide recovery unit and the bypass line each providing a portion of the carbon monoxide-rich gas stream, wherein 30-60% of the one of the reformed gas stream and the syngas stream is bypassed through the bypass line and the one of the reformed gas stream and the syngas stream is first compressed to 10-15 barg.

US Pat. No. 10,508,306

BI-DIRECTIONAL SEQUENCING COMPOSITIONS AND METHODS

LIFE TECHNOLOGIES CORPORA...

1. A method for paired-end nucleic acid bidirectional sequencing comprising:hybridizing a first soluble primer to a distal end of a nucleic acid template strand having a distal and proximal end, wherein the proximal end of the nucleic acid template strand is linked to a support;
sequencing at least a portion of the nucleic acid template strand by extending the hybridized first soluble primer towards the proximal end of the nucleic acid template strand and the support, thereby forming an extended first primer product that is complementary to a portion of the nucleic acid template strand and obtaining a first sequencing read;
introducing a site-specific nick into the proximal end of the nucleic acid template strand which is hybridized to the extended first primer product, wherein the nick includes a free 5? end and a free 3? end;
degrading a portion of the nucleic acid template strand from the free 5? end of the nick using a degrading agent, thereby generating a single-stranded portion within the extended first primer product, wherein a portion of the extended first primer product remains hybridized to an un-degraded portion of the nucleic acid template strand; and sequencing at least a portion of the single-stranded first primer product by extending a primer on the single-stranded first primer product, thereby obtaining a second sequencing read.

US Pat. No. 10,508,305

DNA SEQUENCING AND PROCESSING

1. A method for sequencing a string of oligo-nucleotides, comprising:preparing a template, the template comprising:
a substrate having a plurality of wells; and
a plurality of fragments from a string of oligo-nucleotides attached within the wells,
reading the oligo-nucleotides of the attached fragments; and
processing the read oligo-nucleotides, comprising:
mapping the read oligo-nucleotides along a genome using an alignment method to align the read oligo-nucleotides of each fragment to a reference genome;
detecting redundant fragments; and
sending a termination signal to stop the reading of the redundant fragments responsive to detecting the redundant fragments,
wherein:
the reading and the processing operations are done in a cycle for each oligo-nucleotide of the fragments; and
the redundant fragments include fragments having a threshold number of the same sequentially read oligo-nucleotides with at least one other fragment.

US Pat. No. 10,508,299

MICROFLUIDIC CELL TRAP AND ASSAY APPARATUS FOR HIGH-THROUGHPUT ANALYSIS

The University of British...

1. A microfluidic device comprising:a cell capture chamber, the cell capture chamber comprising:
a first inlet for admitting flow of fluid into the cell capture chamber;
at least one mechanical cell funnel; and
a corresponding trap positioned generally downstream from each of the at least one cell funnels, wherein each or a subset of the corresponding cell traps is a mechanical cell trap,wherein each of the at least one mechanical cell funnels is operable to direct flow of fluid at the corresponding cell trap, and wherein each cell trap is positioned to receive a cell flowing in the fluid downstream from the cell funnel while permitting the fluid and additional cells therein to flow beyond and downstream of the cell trap.

US Pat. No. 10,508,298

METHODS FOR IDENTIFYING A TARGET SITE OF A CAS9 NUCLEASE

President and Fellows of ...

12. A method of selecting a nuclease that specifically cuts a consensus target site from a plurality of nucleases, the method comprising:(a) providing a plurality of candidate nucleases that cut the same consensus sequence;
(b) for each of the candidate nucleases of step (a), identifying a nuclease target site cleaved by the candidate nuclease that differ from the consensus target site using the method of claim 1; and
(c) selecting a nuclease based on the nuclease target site(s) identified in step (b).

US Pat. No. 10,508,290

MEANS AND METHODS FOR METHANE PRODUCTION

QVIDJA KRAFT AB, Helsink...

1. A solid-state fermentation bioreactor comprising:an inlet for CO2 distribution;
an inlet for H2 distribution;
an outlet for water collection;
an outlet for CH4 collection; and
a porous solid support having interstitial spaces, the porous solid support loaded into the solid-state fermentation bioreactor, wherein at least 10% of the pore volumes have a size resulting in a water suction of about 0.01 to about 1.0 bar as compared to free water, the solid support being inoculated with methanogens, the solid-state fermentation bioreactor comprising a solid phase, a liquid phase and a gaseous phase, wherein the liquid phase is discontinuous in the interstitial spaces, wherein the solid phase is distributed in the gaseous phase, and wherein the volume of the gaseous phase is 20% to 80% of the volume of the bioreactor, and wherein the porous solid support has a cation exchange capacity;
provided that vermiculite is not used alone as a solid support.

US Pat. No. 10,508,288

AUTOMATED CELL PROCESSING METHODS, MODULES, INSTRUMENTS, AND SYSTEMS COMPRISING FLOW-THROUGH ELECTROPORATION DEVICES

Inscripta, Inc., Boulder...

1. An automated multi-module cell editing instrument comprising:a housing configured to house all of some of the modules;
one or more receptacles configured to receive cells and nucleic acids;
a flow-through electroporation (FTEP) module configured to introduce the nucleic acids into the cells, wherein the FTEP module comprises:
a. at least a first inlet and a first inlet channel for introducing a fluid comprising the cells and the nucleic acids into the FTEP module;
b. an outlet and an outlet channel for removing a fluid comprising transformed cells from the FTEP module;
c. a flow channel intersecting and positioned between a first inlet channel and the outlet channel; and
d. two or more electrodes positioned in the flow channel between the intersection of the flow channel with the first inlet channel and the intersection of the flow channel with the outlet channel, wherein the electrodes apply one or more electric pulses to the cells in the fluid as they pass through the flow channel thereby introducing the nucleic acids into the cells in the fluid;
a selection module configured to select for transformed cells;
an editing module configured to allow the nucleic acids to edit nucleic acids in the transformed cells;
a processor configured to operate the automated multi-module cell editing instrument based on user input and/or selection of a pre-programmed script; and
an automated liquid handling system to move liquids from the one or more receptacles to the FTEP module, from the FTEP module to the selection module, and from the selection module to the editing module, all without user intervention.

US Pat. No. 10,508,286

METHOD OF DETECTING AND/OR IDENTIFYING ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES IDENTIFIED THEREBY

The Trustees of the Unive...

1. A recombinant adeno-associated virus (AAV) comprising an AAV capsid comprising vp1 proteins having the sequence of amino acids 1 to 738 or a sequence at least 95% identical to the full length of amino acids 1 to 738 of SEQ ID NO: 85, AAV vp2 proteins, and AAV vp3 proteins, wherein the recombinant AAV further comprises, packaged within the capsid, a nucleic acid molecule comprising at least one AAV inverted terminal repeat (ITR), and a non-AAV nucleic acid sequence encoding a gene product operably linked to sequences which direct expression of the product in a host cell, with the proviso that the sequence at least 95% identical to the full length of amino acids 1 to 738 of SEQ ID NO: 85 is not SEQ ID NO: 81.

US Pat. No. 10,508,264

CELL CULTURE METHOD USING BONE MARROW-LIKE STRUCTURE, AND POROUS POLYIMIDE FILM FOR HEALING BONE INJURY SITE

UBE INDUSTRIES, LTD., Ya...

1. A method of inducing differentiation from bone marrow cells derived from a mammal to hematocytes, comprising:(1) applying a first cell group consisting of the bone marrow cells to a porous polyimide film and culturing it;
(2) applying a second cell group consisting of the bone marrow cells to the porous polyimide film after the culturing in step (1), and culturing it; and
(3) adding a differentiation-inducing accelerating substance to the porous polyimide film after the culturing in step (2), and culturing, to accelerate differentiation from the bone marrow cells to the hematocytes,
wherein the porous polyimide film has a three-layer structure consisting of an A-surface layer having a plurality of pores, a B-surface layer having a plurality of pores, and a macro-void layer sandwiched between the two surface layers,
a mean pore size in the A-surface layer is smaller than a mean pore size in the B-surface layer, and
the macro-void layer has a partition bonded to the A-surface layer and the B-surface layer, and a plurality of macro-voids surrounded by the partition, the A-surface layer, and the B-surface layer.

US Pat. No. 10,508,261

CULTURED ALGAE WATER CONCENTRATION SYSTEM, METHOD FOR OPERATING CULTURED ALGAE WATER CONCENTRATION SYSTEM, AND METHOD FOR CONCENTRATING ALGAE WATER CONTAINING CULTURED ALGAE

Kondoh Industries, Ltd., ...

1. A cultured algae water concentration system comprising:an algae water supply unit that receives algae water containing cultured algae from a culture pond, stores the algae water therein, and has an algae water supply container that stores the algae water therein,
a supply container inlet port through which the algae water supply container takes in the algae water, and
a supply container outlet port through which the algae water is taken out from the algae water supply container; and
an algae water concentration unit that concentrates the algae water which has been supplied from the algae water supply unit, and that has
a concentration container for receiving and concentrating the algae water,
a planar filter that divides the concentration container into upper and lower spaces and does not pass algae having a predetermined size or larger therethrough,
a vibration device that vibrates the filter in a
direction that does not lie within a plane of the planar filter when at rest,
a concentration container algae water inlet port that is in communication with the supply container outlet port, takes in the algae water to the concentration container, and is arranged below the filter of the concentration container,
a concentrated algae water outlet port that is arranged below the filter of the concentration container and takes out algae water therethrough that has been concentrated in the concentration container,
a filtered water discharge port that is arranged above the filter of the concentration container and discharges filtered water having passed through the filter,
a liquid level meter that measures a liquid level of the algae water which is stored in the algae water supply container, and
an algae water flow rate adjustment device that adjusts a flow rate of the algae water to be sent to the algae water supply container from the culture pond, based on the liquid level, which has been measured by the liquid level meter,
wherein the filtered water discharge port is arranged at a position that is higher than the highest position on the filter, which is vibrated by the vibration device
wherein
the filter is held by a filter frame that has an annular outer frame and reinforcing plates, of which the sheet number of the reinforcing plates is multiples of 3 and which extend from the center to the annular outer frame in a radial direction at equal central angles,
the vibration device comprises multiple vibration devices,
the reinforcing plates each having a vibration device thereon,
wherein the respective vibration device is connected to the corresponding reinforcing plate of the filter frame or intersections between the corresponding reinforcing plate and the annular outer frame, to vibrate the filter through the filter frame.

US Pat. No. 10,508,259

METHOD FOR RAPID MATURATION OF DISTILLED SPIRITS USING LIGHT, HEAT, AND NEGATIVE PRESSURE PROCESSES

LOST SPIRITS TECHNOLOGY L...

1. A process for producing a mature spirit comprising:(a) providing heat to a mixture consisting essentially of an unmatured distilled spirit and wood, to maintain a temperature between about 140° F. and about 170° F. for a period of time ranging from about 24 hours to about 336 hours to give a distilled spirit mixture; then
(b) contacting the distilled spirit mixture with wood and actinic light at a wavelength spectrum ranging from 400 nm to 1000 nm for at least two hours to give an actinic light-treated distilled spirit mixture; then
(c) providing heat to the actinic light-treated distilled spirit mixture produced in step (b) to maintain a temperature between about 140° F. and about 170° F. for a period of time ranging from about 12 hours to about 336 hours to produce the mature spirit; and then
(d) percolating air through the mature spirit of step (c) in a container with a headspace at a gauge pressure between about ?25 inHg and about ?30 inHg until alcohol concentration of the mature spirit is reduced by between about 1% and about 2% by volume, and until the total volume of the mature spirit is reduced by about 10% or less;
wherein steps (a), (b), (c), and (d) are performed sequentially.

US Pat. No. 10,508,256

DETERGENT COMPOSITION AND MANUFACTURING METHOD THEREOF

1. A detergent composition, comprising:an aqueous phase including liquid water; wherein the content of the liquid water in the detergent composition ranges from 40 wt % to 60 wt %;
an oil phase including a plurality of oil droplets and coffee grounds respectively dispersed in the oil droplets, and the composition of the oil droplets including a foaming agent; wherein the content of the foaming agent in the detergent composition ranges from 15 wt % to 40 wt %, and the content of the coffee grounds in the detergent composition ranges from 1 wt % to 10 wt %; and
an emulsifying agent including a plurality of emulsifier molecules, and each of the emulsifier molecules having a hydrophilic end and a lipophilic end;
wherein the oil droplets are dispersed and suspended in the aqueous phase via the emulsifier molecules to enable the aqueous phase to be formed as a continuous phase, to enable the oil phase to be formed as a discontinuous phase, and to enable the detergent composition to be in the form of oil-in-water;
wherein the hydrophilic ends of the emulsifier molecules are located in the aqueous phase, the lipophilic ends of the emulsifier molecules are respectively located in the oil droplets, and the coffee grounds are respectively covered by the oil droplets and are isolated from the aqueous phase.

US Pat. No. 10,508,255

CLEANING COMPOSITION AND CLEANING METHOD

KAKEN TECH CO., LTD., To...

1. A cleaner composition for cleaning an object of cleaning in a white turbid state,the cleaner composition comprising first to fourth organic solvents and water,
wherein the first organic solvent is at least one compound selected from the group consisting of a hydrophobic aromatic compound, a hydrophobic terpene-based compound, and a hydrophobic naphthene-based compound, all of the compounds having a solubility value in water, at a measurement temperature of 20° C., of 10% by weight or less,
the second organic solvent is a hydrophobic monoalcohol compound having a solubility value in water, at a measurement temperature of 20° C., of 10% by weight or less, and the second organic solvent is at least one selected from the group consisting of 1-hexanol, methyl amyl alcohol, 2-ethyl butyl alcohol, methyl isobutyl carbinol, cyclohexanol, 1-heptanol, 2-heptanol, 3-heptanol, 4-heptanol, 2-methylcyclohexanol, benzyl alcohol, 1-octanol, 2-octanol, 2-ethylhexanol, 2-nonanol, diisobutylcarbinol, and 3,5,5-trimethylhexanol,
the third organic solvent is a hydrophilic nitrogen-containing compound and a hydrophilic sulfur-containing compound, or any one of the compounds, both the compounds having a solubility value in water, at a measurement temperature of 20° C., of 50% by weight or greater, and the hydrophilic nitrogen-containing compound is at least one selected from the group consisting of N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone, dimethylacetamide, N,N-dimethylformamide, and N,N-diethylformamide,
the fourth organic solvent is a hydrophilic amine compound having a solubility value in water, at a measurement temperature of 20° C., of 50% by weight or greater,
the amount of incorporation of the second organic solvent is adjusted to a value within the range of 3 to 100 parts by weight with respect to 100 parts by weight of the first organic solvent,
the amount of incorporation of the third organic solvent is adjusted to a value within the range of 3 to 100 parts by weight with respect to 100 parts by weight of the first organic solvent,
the amount of the fourth organic solvent is adjusted to a value of below 0.1 parts by weight with respect to 100 parts by weight of the first organic solvent,
the amount of incorporation of water is adjusted to a value within the range of 50 to 3,900 parts by weight with respect to 100 parts by weight of the total amount of the organic solvents, and
when the cleaner composition is subjected to phase separation into an oil phase and an aqueous phase, the water concentration in the oil phase, at a measurement temperature of 25° C., is adjusted to a value of 5% by weight or less.

US Pat. No. 10,508,254

PERMEABILITY AND TRANSFORMATION OF CELLS

ARCIS BIOTECHNOLOGY HOLDI...

1. A method of inducing competence in cells, the method comprising contacting the cell with a composition comprising a quaternary ammonium compound including a silicon-containing functional group and a hydrocarbyl-saccharide compound of general formula (III):wherein n is from 5 to 12, preferably from 6 to 10, more preferably from 7 to 9 and m is from 1 to 6, preferably from 2 to 5, more preferably 3 or 4.

US Pat. No. 10,508,251

PREPARATION OF VEGETABLE-BASED STEARIC ACID

MIG Acquisition LLC, Chi...

1. A process for producing a vegetable-based stearic acid product from a vegetable-based product comprising:drying a vegetable-based fat emulsion resulting in a fatty acid and triglyceride mix;
distilling the fatty acid and triglyceride mix to substantially separate the triglycerides from free fatty acids; and
separating the free fatty acids into one or more types of fatty-acids, resulting in a concentrated fatty acid vegetable-based stearic acid product.

US Pat. No. 10,508,250

COMPOSITIONS OF THERMOASSOCIATIVE ADDITIVES WITH CONTROLLED ASSOCIATION AND LUBRICANT COMPOSITIONS CONTAINING THEM

Centre National de la Rec...

1. A composition of additives resulting from mixing at least:a polydiol random copolymer A1;
a random copolymer A2 comprising at least two boronic ester functions and able to associate with the polydiol random copolymer A1 by at least one transesterification reaction; and
an exogenous compound A4 selected from 1,2-diols and 1,3-diols,
wherein a molar percentage of exogenous compound A4 relative to the boronic ester functions of the random copolymer A2 ranges from 0.025 to 5000, and
a weight ratio of the polydiol random copolymer A1 to the random copolymer A2 (A1/A2 ratio) ranges from 0.005 to 200.

US Pat. No. 10,508,245

INTEGRATED SYSTEM FOR BITUMEN PARTIAL UPGRADING

PRAXAIR TECHNOLOGY, INC.,...

1. An integrated system for partially upgrading a hydrocarbon containing heavy oil into a hydrocarbon product, comprising:(a) a reactor with a thermal nozzle operating an oxyfuel combustion process producing a hot gas that atomizes a hydrocarbon containing heavy oil and induces upgrading reactions to produce a reactor effluent containing a partially upgraded oil, wherein the thermal nozzle is configured with a central fuel conduit that extends throughout a combustion chamber to a converging/diverging nozzle, at least one fuel line is disposed around the central fuel conduit, at least two oxygen lines disposed around the fuel line and coextensive thereto to produce the hot gas that automizes the hydrocarbon containing heavy oil;
(b) a heat recovery/process boiler for receiving and cooling the partially upgraded reactor effluent producing steam;
(c) a flash drum for receiving and separating the reactor effluent into a lighter hydrocarbon and cracked combustion gases portion which is removed overhead from the top of the flash drum, and a flash drum bottom portion of heavier oil hydrocarbons;
(d) at least one heat exchanger to cool the product from the top portion of the flush drum; and
(e) a treater to receive the cooled flash drum portion and separate it into a gas fraction, a water fraction and a light hydrocarbon liquid fraction and (4) combining the flash drum bottom portion from step (c) with the light hydrocarbon liquid fraction from step (e) to form a partially upgraded oil product.

US Pat. No. 10,508,244

METHOD FOR REMOVING NITROGEN FROM A HYDROCARBON-RICH FRACTION

LINDE AKTIENGESELLSCHAFT,...

1. A method of obtaining a liquefied hydrocarbon-rich fraction having a nitrogen content of ?1 mol %, said method comprising:liquefying and subcooling a hydrocarbon-rich feed fraction with a refrigeration circuit,
expanding the liquefied and subcooled hydrocarbon-rich feed fraction and feeding the expanded hydrocarbon-rich feed fraction into a nitrogen stripping column,
withdrawing said liquefied hydrocarbon-rich fraction having a nitrogen content of ?1 mol % from the bottom of said nitrogen stripping column,
withdrawing a nitrogen-enriched fraction from the top of said nitrogen stripping column, compressing said nitrogen-enriched fraction, liquefying and subcooling said nitrogen-enriched fraction with the refrigeration circuit, expanding said nitrogen-enriched fraction and feeding said nitrogen-enriched fraction into a high-pressure nitrogen column,
wherein a substream of the nitrogen-enriched fraction which has been cooled with the refrigeration circuit is fed to said high-pressure nitrogen column as a reboil stream, and
withdrawing a nitrogen-depleted fraction from the bottom of said high-pressure nitrogen column and feeding said nitrogen-depleted fraction to the stripping column,
wherein the stripping column and the nitrogen-depleted fraction are thermally coupled via a heat exchanger which serves as reboiler for the nitrogen stripping column and as tops condenser for the high-pressure nitrogen column, and
g) wherein a reflux collector is arranged between the stripping column and the nitrogen-depleted fraction, and a gaseous and/or liquid high-purity nitrogen stream is withdrawn from said reflux collector.

US Pat. No. 10,508,243

METHOD OF MANUFACTURING IRON-BASE CATALYSTS AND METHODS OF MANUFACTURING HYDROCARBONS USING IRON-BASE CATALYSTS MADE BY THE METHOD

Korea Institute of Energy...

1. A method of producing an activated iron-based catalyst, comprising performing an activation of an iron-based catalyst by synthesis gas at a high pressure of 1 to 3 MPa, without performing a separate activation of an iron-based catalyst by synthesis gas at a low pressure of less than 1 MPa,wherein the iron-based catalyst includes ferrihydrite and hematite,
wherein the number of iron atoms in the ferrihydrite is from not less than 10% to not more than 100%, and the number of iron atoms in the hematite is from more than 0% to not more than 90% with respect to 100% of the number of iron atoms in the iron-based catalyst,
wherein the iron-based catalyst is made by using silica (SiO2) as the structural promoter and the mass ratio of iron (Fe) to silica (SiO2) in the iron-based catalyst is Fe:SiO2=100:11 to 100:27.

US Pat. No. 10,508,241

RECOVERY OF HYDROCARBON DILUENT FROM TAILINGS

SYNCRUDE CANADA LTD., Fo...

1. A method for recovering hydrocarbon diluent from tailings comprising bitumen, particulate solids, hydrocarbon diluent and water, the method comprising:providing a high pressure stripping vessel operating at a pressure greater than 100 kPa, the high pressure stripping vessel having internal, vertically and laterally spaced shed decks in its upper portion and a deck-free bottom portion where a tailings pool forms;
introducing a portion of the tailings into the high pressure stripping vessel above the shed decks or in between the shed decks or both, and a portion of the tailings into the tailings pool formed in the high pressure stripping vessel; and
introducing a stripping gas into the high pressure stripping vessel below the shed decks but above the tailings pool or in between the shed decks or both, and into the tailings pool formed in the high pressure stripping vessel to strip the hydrocarbon diluent and water from the tailings.

US Pat. No. 10,508,240

INTEGRATED THERMAL PROCESSING FOR MESOPHASE PITCH PRODUCTION, ASPHALTENE REMOVAL, AND CRUDE OIL AND RESIDUE UPGRADING

Saudi Arabian Oil Company...

1. A method for producing mesophase pitch, the method comprising the steps of:flushing a vessel with nitrogen in addition to or alternative to an inert gas to remove air and oxygen from the vessel;
charging the vessel with a hydrocarbon feed;
pressurizing the vessel to an initial pressure between about 290 pounds per square inch gauge (psig) to about 725 psig;
heating the vessel to a pre-determined temperature; and
maintaining the vessel within about 100° C. of the pre-determined temperature for an amount of time operable to upgrade the hydrocarbon feed to a product comprising mesophase pitch.

US Pat. No. 10,508,238

HALOGEN-FREE SOLID FLAME RETARDANT MIXTURE AND USE THEREOF

Clariant International Lt...

1. A halogen-free flame retardant mixture comprising:1% to 99% by weight of a component A; and
1% to 99% by weight of a component B,wherein:component A comprises 85% to 99.995% by weight of a solid diethylphosphinic salt of the metals Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K, of a protonated nitrogen base or a combination thereof,
0.005% to 15% by weight of noncombustible additions,
component B is aluminum phosphite,
the noncombustible additions are dialkylphosphinic salts of the formula (IV)
wherein R1and R2 are the same or different and are each independently ethyl, butyl, hexyl, octyl or a combination thereof and M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K, a protonated nitrogen base or a combination thereof, with the proviso that R1 and R2 are not both ethyl; and/orthe noncombustible additions are sulfates, phosphates, phosphonates, nitrates, sulfites and/or acetates, where the sulfates, phosphates, phosphonates, nitrates, sulfites and/or acetates are compounds containing cations selected from the group consisting of the alkali metals, the alkaline earth metals, the third main group, and the transition groups of the Periodic Table and/or of protonated nitrogen bases, and
the aluminum phosphite is of the formulae (II) or (III) or a combination of formula (II) with formula (I) or (III) a combination of formula (II) with formula (I) and (III) or a combination of formula (I) and (III)
Al2(HPO3)3x(H2O)q  (I)
wherein
q is 0 to 4,
Al2.00Mz(HPO3)y(OH)vx(H2O)w  (II)
wherein
M is alkali metal ions,
z is 0.01 to 1.5,
y is 2.63 to 3.5,
v is 0 to 2 and
w is 0 to 4,
Al2.00Mz(HPO3)y(OH)vx(H2O)w  (III)
wherein
u is 2 to 2.99,
t is 2 to 0.01 and
s is 0 to 4,mixtures of aluminum phosphite of the formula (I) with sparingly soluble aluminum salts and nitrogen-free foreign ions, mixtures of aluminum phosphite of the formula (III) with aluminum salts, mixtures of 0% to 99.9% by weight of Al2(HPO3)3*nH2O with 0.1% to 100% by weight of sodium aluminum phosphite or a combination thereof.

US Pat. No. 10,508,237

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE THEREOF

JIANGSU HECHENG DISPLAY T...

1. A liquid crystal composition, comprising:1-30% of one or more compounds of general formula I based on the total weight of the liquid crystal composition

1-50% of one or more compounds of general formula II based on the total weight of the liquid crystal composition

1-20% of one or more compounds of general formula III based on the total weight of the liquid crystal composition

20-70% of one or more compounds of general formula IV based on the total weight of the liquid crystal composition
and1-30% of one or more compounds of general formula V based on the total weight of the liquid crystal composition

wherein,
R and R8 are the same or different and each independently represent an alkyl group having 1 to 7 carbon atoms;
R3 represents H or an alkyl group having 1 to 7 carbon atoms;
R4 and R5 are the same or different and each independently represent an alkyl group having 1 to 7 carbon atoms or an alkoxy group having 1 to 7 carbon atoms;
R6 and R7 are the same or different and each independently represent an alkyl group having 1 to 7 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, or an alkenyl group having 2 to 5 carbon atoms;
ring
represents
ring
represents
ring
represents
ring
represents
ring
represents
ring
represents
ring
represents
Y represents —CF3 or —OCF3; X represents —F, —OCF3, or —OCF2—CF?CF2;
b and c are the same or different and each independently represent 0 or 1;
a and d are the same or different and each independently represent 0, 1 or 2;
when a is 2, rings
may be the same or different and each independently represent
when d is 2, rings
may be the same or different and each independently representandwhen X is —OCF3, ring
represents

US Pat. No. 10,508,236

WAVELENGTH CONVERTING MATERIAL FOR A LIGHT EMITTING DEVICE

LUMILEDS LLC, San Jose, ...

1. A luminescent structure comprising:an InxZnyP core, wherein 0?y/x<100, and wherein the InxZnyP core comprises an alloy including both In and Zn; and
a shell disposed on a surface of the core, wherein a difference between a lattice constant of the shell and a lattice constant of the InxZnyP core is less than 1.7% relative to the lattice constant of the shell.

US Pat. No. 10,508,235

FLUORIDE PHOSPHORS AND LIGHT EMITTING DEVICES USING THE SAME

DENKA COMPANY LIMITED, T...

1. A fluoride phosphor, the fluoride phosphor having a composition represented by the general formula (1):A2SiF6:Mn4+  (1)
in which A represents at least one alkali metal comprising at least K; and
the fluoride phosphor having a ratio (A1/A2) of an area (A1) of a spectrum in a range of from 637 eV or more to less than 645 eV in XPS measurement to an area (A2) of a spectrum in a range of from 682.8 eV or more to less than 690 eV in XPS measurement, of 0.0008 to 0.0025.

US Pat. No. 10,508,234

MANUFACTURING, UTILIZATION, AND ANTIFOULING COATING OF HYDROXYL-COVERED SILICON QUANTUM DOT NANOPARTICLE

NATIONAL CHIAO TUNG UNIVE...

1. A method of manufacturing a plurality of hydroxyl-covered silicon quantum dot nanoparticles, comprising:(a) electrochemically etching a surface of a silicon wafer to provide a plurality of silicon cores, wherein each of the silicon cores has a plurality of silicon quantum dots attached thereto;
(b) photochemically hydrosilylating the silicon quantum dots to provide a plurality of hydrosilylated silicon quantum dots, wherein each of the hydrosilylated silicon quantum dots has a plurality of hydrocarbon chains bonded thereto and each of the bonded hydrocarbon chains has a carbon hydroxyl group (C—OH) termination;
(c) releasing the plurality of silicon cores from the surface of the silicon wafer after photochemically hydrosilylating the silicon quantum dots to provide a plurality of released silicon cores;
(d) high energy ball milling the released silicon cores to provide a plurality of crumbled silicon cores, wherein each of the crumbled silicon cores has a first surface portion passivated with a plurality of silicon hydroxyl groups (Si—OH) and a second surface portion attached with the hydrosilylated silicon quantum dots; and
(e) selectively etching the crumbled silicon cores to provide a plurality of etched silicon cores, wherein only the first surface portion of each crumbled silicon core is etched and the second surface portion of each crumbled silicon core is protected by the hydrosilylated silicon quantum dots.

US Pat. No. 10,508,226

NANOSILICA DISPERSION LOST CIRCULATION MATERIAL (LCM)

Saudi Arabian Oil Company...

1. A method to control lost circulation in a lost circulation zone in a carbonate formation, comprising:introducing a lost circulation material (LCM) into the wellbore such that the LCM contacts the lost circulation zone and reduces a rate of lost circulation into the lost circulation zone as compared to a period before introducing the LCM, wherein the LCM consists of an acidic nanosilica dispersion and at least one of: calcium carbonate particles, fibers, mica, and graphite, the acidic nanosilica dispersion consisting of amorphous silicon dioxide, water, and acetic acid, wherein the amorphous silicon dioxide is in the range of 5 weight percentage of the total weight (w/w %) to about 50 w/w % and water is in the range of 50 w/w % to 95 w/w %,
wherein the LCM comprises an initial pH in the range of 2 to 4 before introducing the LCM into the wellbore and a pH of at least 6 after the LCM contacts the lost circulation zone in the carbonate formation,
wherein the LCM forms a gelled solid after contact with the lost circulation zone in the carbonate formation for a contact period in the range of 0.5 hours to 24 hours.

US Pat. No. 10,508,223

EASY-TEAR STICKER AND PROTECTIVE FILM ASSEMBLY

BOE TECHNOLOGY GROUP CO.,...

1. An easy-tear sticker, comprising: a main body layer and a first adhesive layer, the main body layer comprising an attaching part and a tearing part, and the first adhesive layer being disposed on the attaching part,wherein the attaching part comprises a first attaching area and a second attaching area, a shape of the first attaching area is a right-angle triangle, and a shape of the second attaching area is a strip; the tearing part is connected to the attaching part by a first right-angle side of the right-angle triangle, and is configured to be folded toward the attaching part along the first right-angle side, so as to cover a surface of the attaching part facing away from the first adhesive layer.

US Pat. No. 10,508,212

METHOD FOR FORMING MULTILAYER COATING FILM

KANSAI PAINT CO., LTD., ...

1. A method for forming a multilayer coating film, comprising subjecting a substrate to the following steps (1) to (4) in order:step (1): applying an aqueous first colored coating composition (X) to form a first colored coating film,
step (2): applying an aqueous second colored coating composition (Y) to the first colored coating film formed in step (1) to form a second colored coating film,
step (3): applying a clear coating composition (Z) to the second colored coating film formed in step (2) to form a clear coating film; and
step (4): simultaneously bake-curing the first colored coating film, the second colored coating film, and the clear coating film formed in steps (1) to (3),
wherein an aqueous coating composition comprising (A) a film-forming resin, (B) a phosphoric acid compound, and a pigment is applied as the aqueous first colored coating composition (X),
the phosphoric acid compound being represented by the Formula:

wherein m is 1 or 2, n is integer of 1 to 20, and R1 is a substituted or unsubstituted hydrocarbon group having 2 to 20 carbon atoms,
when m is 2, each R1 may be the same or different, and R2 is alkylene having 2 to 4 carbon atoms,
when n is 2 or more, n oxyalkylene units (R2O) may be the same or different,
when m is 2, each (R2O)n may be the same or different, and
wherein the pigment consists of one or more selected from the group consisting of color pigments and extender pigments.

US Pat. No. 10,508,211

INK, INK CONTAINER, RECORDING DEVICE, RECORDING SET AND RECORDING METHOD

RICOH COMPANY, LTD., Tok...

1. An ink comprising:water,
a coloring material;
an organic solvent having a solubility parameter of from 8.0 to 13.0;
an urethane resin particle; and
a metal ion,
wherein the organic solvent having the solubility parameter of from 8.0 to 13.0 has a proportion of from 10.0% by mass to 30.0% by mass to the ink,
wherein the metal ion is at least one selected from a group consisting of an alkali metal ion and an alkaline earth metal ion,
wherein the metal ion has a proportion of from 4000 mg/L to 8000 mg/L to the ink.

US Pat. No. 10,508,210

ACTINIC RAY-CURABLE-TYPE INKJET INK SET FOR THREE-DIMENSIONAL PRINTING, THREE-DIMENSIONAL PRINTING METHOD, AND THREE-DIMENSIONAL PRINTING SYSTEM

FUJIFILM CORPORATION, To...

1. An actinic ray-curable-type inkjet ink set for three-dimensional printing, comprising:a white ink composition W having the following composition; and
a color ink composition C having the following composition,
wherein the white ink composition W contains a white pigment and a polymerizable compound, in which a content of the white pigment is 0.5% by mass to 10% by mass with respect to a total mass of the white ink composition W, and
the color ink composition C contains a colorant, an acrylate monomer AC which forms a homopolymer having a glass transition temperature of 25° C. to 120° C., and an acrylate monomer BC which forms a homopolymer having a glass transition temperature of ?60° C. or higher and lower than 25° C., in which, with respect to a total mass of the color ink composition C, a content of the acrylate monomer AC is 5% by mass or more and less than 50% by mass and a content of the acrylate monomer BC is 20% by mass or more and less than 80% by mass,
wherein the actinic ray-curable-type inkjet ink set for three-dimensional printing further comprises an ink composition for a support material, the ink composition comprising a monofunctional acrylate compound, a polymerization initiator, and a water-soluble non-curing component, in which, with respect to a total mass of the ink composition for a support material, a content of a polyfunctional acrylate compound is 5% by mass or less, and a colorant is not substantially contained in the ink composition for a support material.

US Pat. No. 10,508,208

PROCESS FOR PRINTING MULTICOLOURED PRINTED IMAGES

Merck Patent GmbH, Darms...

1. A process for printing multicoloured printed images in RGB mode on a substrate, which comprises applying successively and solidifying three different colored printing inks in the form of print area units to the substrate,wherein the three different colored printing inks each consist of a printing ink vehicle which is color-pigmented exclusively with interference pigments and one printing ink comprises one or more red interference pigments, one printing ink comprises one or more green interference pigments and one printing ink comprises one or more blue interference pigments,
wherein the print area units lie alongside one another and/or one on top of the other such that a multicolored overall printed image is formed from the three different colored printing inks, and
wherein a yellow print area unit is formed by successive application of the colored printing ink which comprises one or more red interference pigments and the colored printing ink which comprises one or more green interference pigments on top of each other, where the one or more red interference pigments have a hue angle, hu?v?, in the CIELUV color space system in the range from 0° to 25° and the one or more green interference pigments have a hue angle, hu?v?, in the range from 100° to 180°, the hue angle in each case having been determined in a separate, full-area coating of the respective colored printing ink on a black substrate under a measurement condition of 45°/as 25° with a multiangle color spectrophotometer for the 2° or 10° standard observer and D65 light source.

US Pat. No. 10,508,207

COMPOSITIONS INCLUDING A HIGH MOLECULAR WEIGHT ACID SUITABLE FOR CONDUCTIVE POLYMER FORMATION ON DIELECTRIC SUBSTRATE

MacDermid Enthone Inc., ...

1. A composition for the formation of electrically conductive polymers on the surface of a dielectric substrate, the composition comprising:at least one polymerizable monomer which is capable of forming a conductive polymer,
an emulsifier, and
an acid,
wherein the composition comprises at least one metallic or nitrogenous ion selected from the group consisting of lithium-ions, sodium-ions, aluminum-ions, beryllium-ions, bismuth-ions, BxOy-anions, indium-ions, and alkylimidazolium-ion, and
wherein the acid is a polymeric acid having a molecular weight of at least 500,000 Da.

US Pat. No. 10,508,205

CORROSION RESISTANT ADHESIVE SOL-GEL

THE BOEING COMPANY, Chic...

1. A sol-gel comprising:a corrosion inhibitor having one or more thiol moieties; and
a reaction product of:
a hydroxy organosilane represented by Formula (I):

wherein R is C1-20 alkyl, cycloalkyl, ether, or aryl;
a metal alkoxide; and
an acid stabilizer,
wherein:
the sol-gel has a pH from about 3 to about 4, and
a molar ratio of acid stabilizer to metal alkoxide is from about 4:1 to about 6:1.

US Pat. No. 10,508,202

NANOSILICA COATING FOR RETARDING DEW FORMATION

3M INNOVATIVE PROPERTIES ...

3. A method for retarding dew formation on the surface of an article comprising a retro-reflective support, the method comprising the steps of:providing a substrate;
applying a primer coating composition free of silica particles to the surface of the substrate, wherein the primer coating composition comprises a hydrophilic organofunctional silane and a multifunctional acrylic-based additive, wherein the hydrophilic organofunctional silane is 3-(acryloyloxy)propyl trimethyoxysilane, 3-(methacryloyloxy)propyl trimethoxysilane, or a combination thereof, wherein the multifunctional acrylic-based additive is trimethylolpropane trimethacrylate, wherein a weight ratio of the hydrophilic organofunctional silane to the trimethylolpropane trimethacrylate is 95:5 to 60:40;
contacting at least part of the surface of said substrate with a silica nanoparticle coating composition comprising:
an aqueous dispersion of core-shell particles, each core-shell particle comprising a polymer core surrounded by a shell consisting essentially of silica nanoparticles disposed on said polymer core, said aqueous dispersion having a pH of less than 5, and
an acid having a pKa of less than 5;
drying said coating composition so as to provide a silica nanoparticle coating onto said substrate, and thereby forming a coating assembly; and
applying said coating assembly onto at least part of said retro-reflective support.

US Pat. No. 10,508,200

COMPOSITIONS COMPRISING TRIBLOCK COPOLYMERS

INGELL TECHNOLOGIES HOLDI...

1. A composition, comprising:a) 55-98.9 wt. % of at least one type of triblock copolymer (A) of formula (1)
R—B-A-B—R  (1)
b) 0.1-15 wt. % of at least one surfactant (B) and
c) 1-30 wt. % of water,
wherein A is a hydrophilic block having a number average molecular weight (Mn) of 100-1,000 Da, B is a hydrophobic block made from monomers comprising at least a monomer B1 and a monomer B2, wherein B1 and B2 have the largest weight contents in the hydrophobic block and B1 has a lower molecular weight than B2, wherein R is an end group which is H or a C1-030 organic moiety, wherein the composition is fluid in a temperature range of 0° C. to 37° C., wherein the weight % are relative to the sum of a), b) and c), and wherein the sum of components a), b) and c) is at least 80 wt. % of the entire composition.

US Pat. No. 10,508,195

ENVIRONMENT-FRIENDLY MATERIAL, MANUFACTURING METHOD OF WINDOW COVERING SLAT, AND WINDOW COVERING SLAT

Chin-Fu Chen, Taichung (...

1. An environment-friendly material comprising:65 wt % of inorganic mineral powder comprising calcium carbonate 60 wt % and calcium silicate 5 wt % both calcium carbonate and calcium silicate amounts being a percentage of the environment-friendly material;
20 wt % to 30 wt % of polyolefin, selected from a group consisting of linear low density polyethylene, low density polyethylene, medium density polyethylene, high density polyethylene, and polypropylene; and
5 wt % to 15 wt % of auxiliary agent selected from a group consisting of polyolefin elastomer, maleic anhydride grafted polyolefin elastomer, and maleic anhydride grafted polyethylene.

US Pat. No. 10,508,189

POWER INDUCTOR

MODA-INNOCHIPS CO., LTD.,...

1. A power inductor, comprising:a body;
at least two bases disposed in the body;
at least two coils disposed on the at least two bases, respectively;
external electrodes disposed on two outer surfaces of the body which face each other in one direction, the external electrodes being connected to the at least two coils; and
a connection electrode disposed between the external electrodes and on at least one outer surface of the body, the connection electrode connecting the at least two coils to each other,
wherein the body comprises metal powder, a polymer, and a thermal conductive filler for discharging heat of the metal powder to the outside,
the metal powder has a mean particle size of 1 ?m to 50 ?m, and comprises a single kind of particles or two or more kinds of particles, which have a plurality of sizes,
a content of the thermal conductive filler gradually increases in a direction from the base toward upper and lower sides thereof,
wherein the connection electrode connects the at least two coils disposed on different bases of the at least two bases,
wherein the connection electrode directly contacts the at least two coils, and
wherein the connection electrode is formed only on a side surface of the body without extending to upper and lower surfaces of the body.

US Pat. No. 10,508,185

CONTROLLED RELEASE OF ACTIVATION CHEMICALS FOR THE DEPLOYMENT OF SHAPE MEMORY POLYMERS

BAKER HUGHES, A GE COMPAN...

1. A method of installing a downhole device, the method comprising:introducing a downhole device into a wellbore, the downhole device comprising a substrate and a shape memory polymer in a deformed state disposed on the substrate;
combining a modified activation material in the form of a powder with a carrier to provide an activation fluid, the modified activation material comprising a modifying agent and an activation agent, the modifying agent comprising a soluble silicate; a carbohydrate; gelatin; polyvinyl alcohol; polyvinylpyrrolidone; polyacrylic acid; or a combination comprising at least one of the foregoing;
introducing the activation fluid into the wellbore;
releasing the activation agent in a liquid form from the modified activation material in the presence of sonication or an electromagnetic field; and
contacting the shape memory polymer in the deformed state with the released activation agent in an amount effective to deploy the shape memory polymer, the deployed shape memory polymer being an open cell foam having a pore size,
wherein the modified activation material has a particle size less than the pore size of the open cell foam.

US Pat. No. 10,508,183

PLASTIC FILM AND A METHOD FOR MANUFACTURING SAME

LG Chem, Ltd., Seoul (KR...

1. A plastic film of at least partially curved shape, comprising:a substrate,
a coating layer formed on one side of the substrate, said coating layer comprising (i) cationically curable resin, which is a cured product of cationically curable compounds comprising, based on the total weight of the cationically curable compounds, 60 wt % to 100 wt % of 3,4,3?,4?-diepoxybicyclohexyl, and (ii) radically curable resin, and
a coating layer formed on the other side of the substrate, said coating layer comprising (i) cationically curable resin, which is a cured product of cationically curable compounds comprising, based on the total weight of the cationically curable compounds, 20 wt % to 100 wt % of 3,4,3?,4?-diepoxybicyclohexyl, (ii) radically curable resin, and (iii) elastic polymer.

US Pat. No. 10,508,182

DURABLE SUPERHYDROPHOBIC SURFACES

University of Florida Res...

1. A superhydrophobic appliance, comprisinga polydimethylsiloxane network, the polydimethylsiloxane network having elastomeric properties and comprising at least one surface with a multiplicity of re-entrant features,
wherein the multiplicity of re-entrant features render the at least one surface superhydrophobic,
wherein the re-entrant features have at least one dimension of 100 ?m or less,
wherein the re-entrant features comprise non-perpendicular cylinders extending from a base of the at least one surface, and
wherein the polydimethylsiloxane network comprises a plurality of reinforcing metal oxide particles dispersed therein, each of the plurality of reinforcing metal oxide particles having a particle size less than about 100 ?m.

US Pat. No. 10,508,181

BOTTOM LAYER FILM-FORMATION COMPOSITION OF SELF-ORGANIZING FILM CONTAINING POLYCYCLIC ORGANIC VINYL COMPOUND

NISSAN CHEMICAL INDUSTRIE...

1. An underlayer film-forming composition for a self-assembled film, the underlayer film-forming composition comprising a polymer including:60% by mole to 95% by mole of a unit structure of an aromatic vinyl compound relative to all the unit structures of the polymer,
5% by mole to 40% by mole of a unit structure having a crosslinkable group having a hydroxy group, an epoxy group, a protected hydroxy group, or a protected carboxy group relative to all the unit structures of the polymer, and
1% by mole or more of a unit structure of a polycyclic aromatic vinyl compound relative to all unit structures of the polymer,
wherein the aromatic vinyl compound includes an optionally substituted vinylnaphthalene, an optionally substituted acenaphthylene, or an optionally substituted vinylcarbazole, and the polycyclic aromatic vinyl compound is vinylnaphthalene, acenaphthylene, or vinylcarbazole, and
the self-assembled film is a film formed from a block polymer that comprises an organic polymer chain (A) including an organic monomer (a) as a unit structure and an organic polymer chain (B) including a monomer (b) different from the organic monomer (a) as a unit structure and is formed by bonding the organic polymer chain (B) to the organic polymer chain (A).

US Pat. No. 10,508,180

METHOD FOR PRODUCING FIBRE COMPOSITES FROM AMORPHOUS, CHEMICALLY MODIFIED POLYMERS

INEOS STYROLUTION GROUP G...

1. A process for producing a thermoplastic fiber composite material from a thermoplastic matrix M comprising at least one thermoplastic molding compound A and reinforcing fibers B, comprising the steps of:i) providing at least one sheetlike structure F composed of reinforcing fibers B,
ii) introducing the at least one sheetlike structure F into a thermoplastic matrix M,
iii) reacting functional groups in the thermoplastic matrix M with polar groups on the surface of the reinforcing fibers B,
iv) consolidating the fiber composite material, and
v) optionally cooling and further process steps,
wherein the sheetlike structure F is selected from the group consisting of weaves, mats, nonwovens, scrims, and knits,
wherein the sheetlike structure F permeates more than 50% of the area of the fiber composite material in two of the three spatial directions, and
wherein step (iii) is conducted at a temperature of at least 200° C. wherein the residence time at temperatures of at least 200° C. is not more than 10 minutes.

US Pat. No. 10,508,177

METHOD AND DEVICE FOR PURIFYING POLYBUTYLENE TEREPHTHALATE

NATIONAL TSING HUA UNIVER...

1. A method for purifying polybutylene terephthalate (PBT), comprising:providing or receiving initial PBT, wherein the initial PBT comprises oligomers;
dissolving the initial PBT in hexafluoroisopropanol (HFIP) to form a PBT/HFIP solution, wherein the oligomers are dissolved in the HFIP, wherein a weight percent of the initial PBT in the PBT/HFIP solution is in a range of about 1 wt % to about 8 wt %; and
contacting the PBT/HFIP solution with compressed carbon dioxide (CO2) at a temperature of 20° C. to 35° C. and a pressure of 900 psi to 1400 psi, thereby precipitating purified PBT at the temperature and the pressure, wherein at least a portion of the oligomers are still dissolved in the HFIP.

US Pat. No. 10,508,168

THERMOPLASTIC POLYMER, METHOD OF PREPARING THERMOPLASTIC POLYMER, AND THERMOPLASTIC POLYMER COMPOSITION INCLUDING THERMOPLASTIC POLYMER

LG CHEM, LTD., Seoul (KR...

1. A thermoplastic rubber polymer comprising one or more selected from the group consisting of:an unsaturated branched chain fatty acid with a main chain unsaturation degree of 1 to 20;
an unsaturated chain-type fatty acid with a main chain unsaturation degree of 1 to 20 and comprising a functional group;
a salt of the branched chain fatty acid, and
a salt of the fatty acid comprising the functional group,
wherein the functional group is a hydroxyl group or a C1-C10-alkoxy group.

US Pat. No. 10,508,158

WATER DISPERSION OF GEL PARTICLES, PRODUCING METHOD THEREOF, AND IMAGE FORMING METHOD

FUJIFILM CORPORATION, To...

1. A water dispersion of gel particles,wherein the gel particles have a three-dimensional crosslinked structure including a structural unit represented by Formula (1) and a urea bond, have a hydrophilic group, include photopolymerization initiators and are dispersed in water,

R1 in Formula (1) represents a hydrogen atom or an alkyl group,
X1 in Formula (1) represents a cyano group, a lactam group, a —C(?O)X2R2 group, an —OC(?O)R3 group, or an aryl group,
X2 represents an oxygen atom or an —N(RX2)— group, and RX2 represents a hydrocarbon group that may contain a hetero atom or a hydrogen atom,
R2 represents a hydrocarbon group that may contain a hetero atom or a hydrogen atom, provided that, in a case in which X2 is an oxygen atom, R2 is not a hydrogen atom,
R2 and RX2 may be bonded to each other to form a ring,
R3 represents a hydrocarbon group that may contain a hetero atom, and
a content of the structural unit represented by Formula (1) in the three-dimensional crosslinked structure is 60 mass % or greater with respect to a total amount of the three-dimensional crosslinked structure.

US Pat. No. 10,508,134

PEPTIDE COMPOSITIONS AND METHODS OF USE

ONL Therapeutics, Inc., ...

1. A compound of Formula I,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,508,126

BISPHOSPHONATES VINYLIC MONOMERS AND POLYMERS AND USES THEREOF

Bar-Ilan University, Ram...

1. A particle comprising a compound or a polymer comprising a formula selected from the group consisting of:
wherein X is H, CH3, CN, phenyl, substituted phenyl, (CH2)mZ, or phenyl(CH2)mZ;
T is O, S or NH;
m equals 1 to 20;
n equals 1-100; and
Z is CN, NH2, Thiol, OH, or CO2H;

wherein X is H, CH3, CN, phenyl, substituted phenyl, (CH2)mZ, or phenyl(CH2)mZ; and
Z is CN, NH2, Thiol, OH, or CO2H;
or

wherein:
R1, R2, R3, and R4 are independently: H, CH3, OH, or a halogen; and
wherein said particle has a particle size ranging from 40 nm to 2.2 ?m.

US Pat. No. 10,508,122

HETEROCYCLIC HYDROXAMIC ACIDS AS PROTEIN DEACETYLASE INHIBITORS AND DUAL PROTEIN DEACETYLASE-PROTEIN KINASE INHIBITORS AND METHODS OF USE THEREOF

The Regents of the Univer...

1. A compound of formula (II):
or a pharmaceutically acceptable salt thereof,
wherein:
ring A is an optionally substituted aryl or optionally substituted heteroaryl;
rings B and C taken together form a purine, imidazopyridine, pyrazolopyrimidine, pyrazolopyridine, pyrrolopyrimidine, thiazolopyrimidine, indole, pyrrolopyrimidinone or dihydropyrrolopyrimidine;
Z is N, CR2, O, S, C?O, SO or SO2;
R1 is C1-C6 alkyl, haloalkyl, hydroxyalkyl, carboxyalkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclic or carbocyclic, each of which is optionally substituted, or R1 is H or is absent, and wherein when Z is CR2, R1 and R2 taken together with the carbon atom to which they are attached may form a 3-7 membered ring which is optionally substituted;
X is O, S, SO, CO, CR2R3, NR4, CONR4, NR4CO, NR4CO2, NR4(CO)NR5 or a bond;
Y is C1-C6 alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, (CH2)n-aryl, (CH2)n-heteroaryl, OR3, SR3, COR3, COOR3, SOR3, SO2R3, SO2NR4R5, NR4R5, NR4SO2R3, NR4COR3, NR4CO2R3, CONR4R5, CO2NR4R5 or NR4(CO)NR5, each of which is optionally substituted, or Y is H, CN, Cl, Br, I, F or is absent, and where R4 and R5 taken together with the nitrogen atom to which they are attached may form a 4-7 membered ring which is optionally substituted;
L is C1-C9 alkylene, C2-C9 alkenylene or C2-C9 alkynylene, any of which is optionally substituted, wherein one or more of the carbon atoms of the alkylene, alkenylene or alkynylene is optionally replaced with O, S, NR4, CO, CONR4, NR4CO, CO2NR4, NR4CO2, NR4(CO)NR5, a cycloalkyl or a heterocycle, with the proviso that heteroatoms are not bonded directly to alkenyl or alkynyl carbons, and that the carbon atom adjacent to X shall not be optionally replaced such that a heteroatom-heteroatom bond results;
each R2 is independently C1-C6 alkyl, alkoxy, aryl, (CH2)n-aryl, heteroaryl, (CH2)n-heteroaryl, cycloalkyl or heterocyclic, each of which is optionally substituted, or R2 is H or hydroxy;
R3 is C1-C6 alkyl, alkoxy, aryl, (CH2)n-aryl, heteroaryl, (CH2)n-heteroaryl, cycloalkyl or heterocyclic, each of which is optionally substituted, or R3 is H;
R4 is C1-C6 alkyl, aryl, (CH2)n-aryl, heteroaryl, (CH2)n-heteroaryl, cycloalkyl or heterocyclic, each of which is optionally substituted, or R4 is H;
R5 is C1-C6 alkyl, aryl, (CH2)n-aryl, heteroaryl, (CH2)n-heteroaryl, cycloalkyl or heterocyclic, each of which is optionally substituted, or R5 is H; and
n is 1-4.

US Pat. No. 10,508,120

TYK2 INHIBITORS AND USES THEREOF

Nimbus Lakshimi, Inc., C...

1. A compound selected from the group consisting of:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,508,119

PYRAZOLE DERIVATIVES USEFUL AS 5-LIPDXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS

1. A compound according to Formula (I):or a pharmaceutically acceptable salt thereof, wherein:R1 is H, C1-C3 alkyl, halo, C1-C3 alkoxy, C1-C3 haloalkyl or C1-C3 haloalkoxy;
each of R2 and R3 is independently H, C1-C3 alkyl, C1-C3 alkoxy, —CN or halo;
R4 is H, —CH3, —CH2F, —CHF2, —CF3 or halo;
Ring A contains 2 double bonds;
each X1, X2, X3 and X4 of Ring A is independently CR5, CH, O, S, NR6 or N; wherein at least one of X1, X2, X3 and X4 in Ring A is NR6;
each R5 is optionally and independently C1-C6 alkyl, C1-C6 alkoxy, C1-C3 haloalkyl, C1-C3 haloalkoxy, —S(O)pR7, —CN, —CONR?R?, or C3-C6 cycloalkyl;
each p is independently 0, 1 or 2;
R6 is H, —CH3 or CH2CH3;or wherein when X4 is CR5 and X3 is NR6, then the R5 and R6 may be taken together to form a 5 to 6-membered heterocyclyl ring fused to Ring A, which heterocyclyl may optionally contain an additional heteroatom selected from N, O and S; said fused heterocyclyl may additionally contain a carbonyl or a S(O)2 directly adjacent to a heteroatom therein; and may be further substituted with one or two substituents selected from the group consisting of —CH3 and halo;R7 is —CH3 or —NR?R?; andeach R? and R? is independently —H or —CH3;provided that the total number of substituents on Ring A is 0, 1 or 2; and further provided that when R5 and R6 are not combined to form a heterocyclyl ring fused to Ring A, that the total number of R5 and R6 substituents which is alkyl and/or haloalkyl is 0 or 1.

US Pat. No. 10,508,118

PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF

Xiamen University, Fujia...

1. A compound of formula I:whereinR? is H, Cl or Br;
R1 is selected from the group consisting of:
2)

 wherein Z1, Z2, Z3, Z4, Z5 are independently selected from the group consisting of:
(1) H, F, Cl, Br, I, nitro, cyano;
(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxyalkyl, C1-C6 fluoroalkyl, C1-C6 fluoroalkoxy, N-methyl-4-piperidyl;
(3) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholinoethylamino, 2-(4-N-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-N-methylpiperazinyl)propylamino, N-methylpiperid-4-ylamino, N-ethylpiperid-4-ylamino, N-isopropylpiperid-4-ylamino;
(4) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(N-methylpiperazinyl)ethoxy, 2-(N-acetylpiperazinyl)ethoxy, 2-morpholinoethoxy, 2-thiomorpholinoethoxy, 2-piperidylethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-(N-methylpiperazinyl)propoxy, 3-(N-acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiomorpholinoethoxy, 3-piperidylpropoxy, 2-pyridylmethoxy, 3-pyridylmethoxy, 4-pyridylmethoxy, phenylmethoxy, monohalogen-substituted phenyl methoxy, gem-dihalogen substituted phenyl methoxy, hetero-dihalogen substituted phenyl methoxy;
(5) piperidyl, 4-N,N-dimethylaminopiperidyl, 4-N,N-diethylaminopiperidyl, 4-N,N-diisopropylaminopiperidyl, 4-hydroxypiperidyl, morpholino, 3,5-dimethylmorpholino, thiomorpholino, pyrrolidinyl, 3-N,N-dimethylpyrrolidinyl, 3-N,N-diethylpyrrolidinyl, N-methylpiperazinyl, N-ethylpiperazinyl, N-ispropylpiperazinyl, N-acetylpiperazinyl, N-tert-butoxyformylpiperazinyl, N-methylsulfonylpiperazinyl, N-(2-hydroxyethyl)piperazinyl, N-(2-cyanoethyl)piperazinyl, N-(3-hydroxypropyl)piperazinyl, N-(2-N,N-dimethylethyl)piperazinyl, N-(2-N,N-diethylethyl)piperazinyl, N-(3-N,N-dimethylpropyl)piperazinyl, N-(3-N,N-diethylpropyl)piperazinyl, 2-oxo-piperazin-4-yl, imidazolyl, 4-methylimidazolyl;
(6) 4-(N-methylpiperazinyl)piperidyl, 4-(N-ethylpiperazinyl)piperidyl, 4-(N-isopropylpiperazinyl)piperidyl, 4-(N-acetylpiperazinyl)piperidyl, 4-(N-tert-butoxyformyl)piperazinyl)piperidyl, 4-(N-methylsulfonylpiperazinyl)piperidyl, 4-(N-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(N-(2-cyanoethyl)piperazinyl)piperidyl, 4-(N-(3-hydroxypropyl)piperazinyl)piperidyl, 4-(N-(2-N,N-dimethylethyl)piperazinyl)piperidyl, 4-(N-(2-N,N-diethylethyl)piperazinyl)piperidyl, 4-(N-(3-N,N-dimethylpropyl)piperazinyl)piperidyl, 4-(N-(3-N,N-diethylpropyl)piperazinyl)piperidyl, 4-(pyrrolidinyl)piperidyl, 4-(3-N,N-dimethylpyrrolidinyl)piperidyl, N—(N-methyl-4-piperidyl)piperazinyl, N—(N-ethyl-4-piperidyl)piperazinyl;
(7) hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylaminosulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylpiperidin-1-ylsulfonyl, 4-N,N-diethylpiperidin-1-ylsulfonyl, pyrrolidin-1-ylsulfonyl, 3-N,N-dimethylpyrrolidin-1-ylsulfonyl, 3-N,N-diethylpyrrolidin-1-ylsulfonyl, N-methylpiperazin-1-ylsulfonyl, N-ethylpiperazin-1-ylsulfonyl, N-acetylpiperazin-1-ylsulfonyl, N-tert-butoxyformylpiperazin-1-ylsulfonyl, N-(2-hydroxyethyl)piperazin-1-ylsulfonyl, N-(2-cyanoethyl)piperazin-1-ylsulfonyl, N-(2-N,N-dimethylethyl)piperazin-1-ylsulfonyl, N-(2-N,N-diethylethyl)piperazin-1-ylsulfonyl, N-(3-hydroxypropyl)piperazin-1-ylsulfonyl, N-(3-N,N-dimethylpropyl)piperazin-1-ylsulfonyl, N-(3-N,N-diethylpropyl)piperazin-1-ylsulfonyl, morpholino-1-sulfonyl, 3,5-dimethylmorpholino-1-sulfonyl, 4-(N-methyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(N-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(N-acetyl-1-piperazinyl)piperidin-1-ylsulfonyl, N—(N-methyl-4-piperidyl)piperazin-1-ylsulfonyl;
(8) hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidin-1-ylcarbonyl, 4-hydroxypiperidin-1-ylcarbonyl, 4-N,N-dimethylpiperidin-1-ylcarbonyl, 4-N,N-diethylpiperidin-1-ylcarbonyl, pyrrolidin-1-ylcarbonyl, 3-N,N-dimethylpyrrolidin-1-ylcarbonyl, 3-N,N-diethylpyrrolidin-1-ylcarbonyl, N-methylpiperazin-1-ylcarbonyl, N-ethylpiperazin-1-ylcarbonyl, N-acetylpiperazin-1-ylcarbonyl, N-tert-butoxycarbonylpiperazin-1-ylcarbonyl, N-(2-hydroxyethyl)piperazin-1-ylcarbonyl, N-(2-cyanoethyl)piperazin-1-ylcarbonyl, N-(2-N,N-dimethylethyl)piperazin-1-ylcarbonyl, N-(2-N,N-diethylethyl)piperazin-1-ylcarbonyl, N-(3-hydroxypropyl)piperazin-1-ylcarbonyl, N-(3-N,N-dimethylpropyl)piperazin-1-ylcarbonyl, N-(3-N,N-diethylpropyl)piperazin-1-ylcarbonyl, morpholino-1-carbonyl, 3,5-dimethylmorpholino-1-carbonyl, 4-(N-methyl-1-piperazinyl)piperidin-1-ylcarbonyl, 4-(N-ethyl-1-piperazinyl)piperidin-1-ylcarbonyl, 4-(N-acetyl-1-piperazinyl)piperidin-1-ylcarbonyl, N—(N-methyl-4-piperidyl)piperazin-1-ylcarbonyl;
(9) methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl;
(10) aminoformamido, methylaminoformamido, ethylaminoformamido, propylaminoformamido, isopropylaminoformamido, cyclopropylaminoformamido, cyclobutylaminoformamido, cyclopentylaminoformamido, piperidin-1-ylformamido, 4-hydroxypiperidin-1-ylformamido, 4-N,N-dimethylpiperidin-1-ylformamido, 4-N,N-diethylpiperidin-1-ylformamido, pyrrolidin-1-ylformamido, 3-N,N-dimethylpyrrolidin-1-ylformamido, 3-N,N-diethylpyrrolidin-1-ylformamido, N-methylpiperazin-1-ylformamido, N-ethylpiperazin-1-ylformamido, N-acetylpiperazin-1-ylformamido, N-tert-butoxycarbonylpiperazin-1-ylformamido, N-(2-hydroxyethyl)piperazin-1-ylformamido, N-(2-cyanoethyl)piperazin-1-ylformamido, N-(2-N,N-dimethylethyl)piperazin-1-ylformamido, N-(2-N,N-diethylethyl)piperazin-1-ylformamido, N-(3-hydroxypropyl)piperazin-1-ylformamido, N-(3-N,N-dimethylpropyl)piperazin-1-ylformamido, N-(3-N,N-diethylpropyl)piperazin-1-ylformamido, morpholino-1-formamido, 3,5-dimethylmorpholino-1-formamido, 4-(N-methyl-1-piperazinyl)piperidin-1-ylformamido, 4-(N-ethyl-1-piperazinyl)piperidin-1-ylformamido, 4-(N-acetyl-1-piperazinyl)piperidin-1-ylformamido, N—(N-methyl-4-piperidyl)piperazin-1-ylformamido;
(11) aminoacetamido, N-tert-butoxycarbonylacetamido, N-acetylaminoacetamido, acrylamido, cyclopropionamido, chloroacetamido, piperidylacetamido, 4-hydroxypiperidylacetamido, 4-N,N-dimethylpiperidylacetamido, 4-N,N-diethylpiperidylacetamido, pyrrolidinylacetamido, 3-N,N-dimethylpyrrolidinylacetamido, 3-N,N-diethylpyrrolidinylacetamido, N-methylpiperazinylacetamido, N-ethylpiperazinylacetamido, N-acetylpiperazinylacetamido, N-tert-butoxycarbonylpiperazinylacetamido, N-(2-hydroxyethyl)piperazinylacetamido, N-(2-cyanoethyl)piperazinylacetamido, N-(2-N,N-dimethylethyl)piperazinylacetamido, N-(2-N,N-diethylethyl)piperazinylacetamido, N-(3-hydroxypropyl)piperazinylacetamido, N-(3-N,N-dimethylpropyl)piperazinylacetamido, N-(3-N,N-diethylpropyl)piperazinylacetamido, morpholino-1-acetamido, 3,5-dimethylmorpholinoacetamido, 4-(N-methyl-1-piperazinyl)piperidylacetamido, 4-(N-ethyl-1-piperazinyl)piperidylacetamido, 4-(N-acetyl-1-piperazinyl)piperidylacetamido, N—(N-methyl-4-piperidyl)piperazinylacetamido; 4-(pyrrolidin-1-yl)piperidylacetamido, 2-methylaminoacetamido, 2-(1-methylethyl)aminoacetamido; N-benzyloxycarbonyl-2-methylaminoacetamido;
(12) Z2 and Z3 can form substituted or unsubstituted 5- or 6-membered oxygen-containing ring; the substituents may be selected from the same substituents for Z1;
(13) Z2 and Z3 can form substituted or unsubstituted 5- or 6-membered nitrogen-containing ring; the substituents may be selected from the same substituents for Z1;
A is a direct bond;
X is a NH, S or O;
R2 is selected from the group consisting of:
2)

 wherein A1 is selected from the group consisting of:
(1) F, Cl, Br, I, cyano, trifluoromethyl, trifluoromethoxy, nitro;
(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methylsulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinyl, diethylphosphinyl, diisopropylphosphinyl;
wherein A3 is selected from the group consisting of:
(1) H, F, trifluoromethyl, trifluoromethoxy, nitro;
(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methylsulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinyl, diethylphosphinyl, diisopropylphosphinyl;
wherein A2, A4 and A5 are independently selected from the group consisting of:
(1) H, F, Cl, Br, I, cyano, trifluoromethyl, trifluoromethoxy, nitro;
(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methylsulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinyl diethylphosphinyl, diisopropylphosphinyl;
3)

wherein Y is NH, S or O,
A6, A7, As, A9, A10, A11 are independently selected from the group consisting of:
(1) H, F, Cl, Br, I, cyano, trifluoromethyl, trifluoromethoxy, nitro;
(2) methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl;
4)

wherein A12 is selected from the group consisting of:
(1) H, F, Cl, Br, I, cyano, trifluoromethyl, trifluoromethoxy, nitro,
(2) methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl;
Y2, Y3, Y4 are selected from the group consisting of:
Y2 is N, Y3 is N-A13, Y4 is CH or N;
Y2 is N, Y3 is C-A13, Y4 is N, O or S;
Y2 is O or S, Y3 is N-A13, Y4 is CH;
Y2 is O or S, Y3 is C-A13, Y4 is N; and
Y2 is C, Y3 is N-A13, Y4 is O or S;
wherein A13 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl;
R3 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, or a stereoisomer, a pharmaceutically acceptable salt, or a pharmaceutically acceptable solvate thereof.

US Pat. No. 10,508,116

CLICK NUCLEIC ACID POLYMERS AND METHODS OF USE

THE REGENTS OF THE UNIVER...

1. A Click Nucleic Acid polymer (CNA) having the formula:
wherein each NB is the same or different nucleobase, the index m is an integer from 1 to 20 and n is an integer from 0 to 100.

US Pat. No. 10,508,115

TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING HETEROATOM-LINKED AROMATIC MOIETIES, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR

Bristol-Myers Squibb Comp...

1. A compound represented by formula (I) or (II)whereinR1 is (C1-C5 alkyl)O, (C1-C2 alkyl)O(CH2)2-3O, (C1-C5 alkyl)C(?O)O, (C1-C5 alkyl)NH, (C1-C2 alkyl)O(CH2)2-3NH, or (C1-C5 alkyl)C(?O)NH;
R2 is, independently for each occurrence thereof, H, C1-C3 alkyl, halo, O(C1-C3 alkyl), CN, or NO2;
X is, independently for each occurrence thereof, CR2 or N;
R3 is O, S, NH, or N(C1-C3 alkyl);
Ar is

where one of Y, Y? and Y? is selected from —O—, —S—, —NH— and —N(C1-C3 alkyl)- and the other two of Y, Y?, and Y? are selected from ?N— and ?CR2—;
R4 is H, C1-C3 alkyl, halo, O(C1-C3 alkyl), CN, NO2, or (CH2)xR5, where the subscript x is 1, 2, 3, or 4; and
R5 is H, halo, OH, CN, NH2, NH(C1-C5 alkyl), N(C1-C5 alkyl)2, NH(C3-C6 cycloalkyl), NH(C4-C8 bicycloalkyl), NH(C6-C10 spirocycloalkyl), N(C3-C6 cycloalkyl)2, NH(CH2)1-3(aryl), N((CH2)1-3(aryl))2, a cyclic amine moiety having the structure

 a 6-membered aromatic or heteroaromatic moiety or a 5-membered heteroaromatic moiety;
wherein
an alkyl, cycloalkyl, bicycloalkyl, spriocycloalkyl, cyclic amine, 6-membered aromatic or heteroaromatic, or 5-membered heteroaromatic moiety is optionally substituted with one or more substituents selected from OH, halo, CN, (C1-C3 alkyl), O(C1-C3 alkyl), C(?O)(Me), SO2(C1-C3 alkyl), C(?O)(Et), NH2, NH(Me), N(Me)2, NH(Et), N(Et)2, and N(C1-C3 alkyl)2; and
a cycloalkyl, bicycloalkyl, spiroalkyl, or cyclic amine moiety may have a CH2 group replaced by O, S, NH, N(C1-C3 alkyl), or N(Boc).

US Pat. No. 10,508,114

SPIRO-ISOQUINOLINE-4,4?-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

ESTEVE PHARMACEUTICALS, S...

17. A pharmaceutical composition which comprises the compound according to claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

US Pat. No. 10,508,113

INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING

AbbVie Inc., North Chica...

1. A compound of Formula (II-a):
or a pharmaceutically acceptable salt thereof;
wherein:
R1 is unsubstituted or substituted C1-3alkyl, unsubstituted or substituted C3-4carbocyclyl, or unsubstituted or substituted 4- to 5-membered heterocyclyl;
R2 is -NH2, -NHR2a, unsubstituted or substituted C1-3alkyl, and R2a is unsubstituted or substituted C1-3alkyl;
R3 is -(C1-3alkylene)m-OR3a, -(C1-3alkylene)m-N(R3a)2, C1-3alkyl, or C1-3haloalkyl, wherein m is 0 or 1, and each instance of R3a is independently hydrogen, C1-3alkyl, or C1-3haloalkyl;
each instance of R4a and R4ab is hydrogen;
R5 is hydrogen, -CN, -OR5a, -NHR5a, or unsubstituted or substituted C1-6alkyl, wherein R5a is unsubstituted or substituted C1-6alkyl, unsubstituted or substituted C3-6carbocyclyl, unsubstituted or substituted C3-6carbocyclylC1-3alkyl, unsubstituted or substituted 4- to 6-membered heterocyclyl, or unsubstituted or substituted 4- to 6-membered heterocyclylC1-3alkyl;
n is 1; and
each instance of substituted is independent substitution with 1, 2, or 3 substituents selected from the group consisting of halogen, -CN, -OH, C1-3alkyl, C1-3haloalkyl, -OC1-3alkyl, and -OC1-3haloalkyl.

US Pat. No. 10,508,112

INTERMEDIATE COMPOUNDS FOR PREPARATION OF PRAZIQUANTEL AND PROCESSES FOR PREPARING THE INTERMEDIATE COMPOUNDS

Zhejiang Hisun Pharmaceut...

1. An intermediate compound for preparing Praziquantel, having the structure of formula IV:

US Pat. No. 10,508,111

6-[5-AMINO-6-(2-ETHOXYETHOXY)-IMIDAZO[4,5-B]PYRIDIN-3-YL]-NICOTINONITRILE DERIVATIVES AND THEIR USE AS IRAK INHIBITORS

GALAPAGOS NV, Mechelen (...

1. A compound according to Formula I:whereinCy is
monocyclic C3-7 cycloalkyl optionally substituted with one or more independently selected R3, or
4-7 membered monocyclic heterocycloalkyl comprising one or two heteroatoms independently selected from N, S, or O, optionally substituted with one or more independently selected R3;
R1 is
H,
—SO3H,
—P(?O)(OH)2,
C1-4 alkyl,
—C(?O)-(4-7 membered monocyclic heterocycloalkyl comprising one or two heteroatoms independently selected from N, S, or O), or
—C(?O)C1-6 alkyl, which C1-6 alkyl is optionally substituted with one or more independently selected R4 groups;
R2 is H or C1-4 alkyl;
each R3 is independently selected from:
OH,
?O,
halo, or
C1-4 alkyl;
each R4 is independently selected from:
—NR5aR5b,
—C(?O)OH,
4-7 membered monocyclic heterocycloalkyl comprising one or two heteroatoms independently selected from N, S, or O, optionally substituted with one or more independently selected C1-4 alkyl, or
—NHC(?O)—C1-4 alkyl-NH2; and
R5a and R5b are independently H or C1-4 alkyl;or a pharmaceutically acceptable salt or a solvate or the salt of a solvate thereof.

US Pat. No. 10,508,109

BICYCLIC COMPOUND AND USE THEREOF FOR INHIBITING SUV39H2

ONCOTHERAPY SCIENCE, INC....

1. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof:
wherein
R1 is selected from the group consisting of a halogen atom, hydroxy, C1-C6 alkyl, and C1-C6 alkoxy, wherein the alkyl and the alkoxy may be substituted with one or more substituents selected from A1;
R2 is selected from the group consisting of a hydrogen atom, a halogen atom, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, and C3-C10 cycloalkoxy, wherein the alkyl and the alkoxy may be substituted with one or more substituents selected from A2;
R3 is independently selected from the group consisting of a halogen atom, cyano, nitro, hydroxy, carboxy, C1-C6 alkyl, C1-C6 alkoxy, (C1-C6 alkoxy)carbonyl, C1-C6 alkylthio, C1-C6 alkylsulfinyl, and C1-C6 alkylsulfonyl;
n is an integer selected from 0 to 3;
X1 is N and X2 is N; or
X1 is CR4 and X2 is N or CR6;
R4 is selected from the group consisting of a hydrogen atom, a halogen atom, C1-C6 alkyl, and C1-C6 alkoxy;
R5 and R6 are independently selected from the group consisting of a hydrogen atom, a halogen atom, and Y, wherein at least one of R5 and R6 is Y;
Y is independently selected from the group consisting of —NR11R12, C10 cycloalkyl optionally substituted with one or more substituents selected from Rc, C6-C10 aryl optionally substituted with one or more substituents selected from Rd, 3- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Re, and 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rf;
R11 is selected from the group consisting of a hydrogen atom, C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Rb, C6-C10 aryl optionally substituted with one or more substituents selected from Rb, 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rb, 3- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Rb, (C1-C6 alkoxy)carbonyl optionally substituted with one or more substituents selected from Ra, (C1-C6 alkyl)carbonyl optionally substituted with one or more substituents selected from Ra, (C3-C10 cycloalkyl)carbonyl optionally substituted with one or more substituents selected from Rg, (C6-C10 aryl)carbonyl optionally substituted with one or more substituents selected from Rh, (3- to 12-membered non-aromatic heterocyclyl)carbonyl optionally substituted with one or more substituents selected from Rg, (5- to 10-membered heteroaryl)carbonyl optionally substituted with one or more substituents selected from Rg, aminocarbonyl, (C1-C6 alkyl)aminocarbonyl, and di(C1-C6 alkyl)aminocarbonyl;
R12 is selected from the group consisting of a hydrogen atom, and C1-C6 alkyl optionally substituted with one or more substituents selected from Ra;
R13 is selected from the group consisting of a hydrogen atom, C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Rg, C6-C10 aryl optionally substituted with one or more substituents selected from Rh, 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rg, and 3- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Rg;
R14 is selected from the group consisting of a hydrogen atom, and C1-C6 alkyl optionally substituted with one or more substituents selected from Ra;
R15 is selected from the group consisting of C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Rc, C6-C10 aryl optionally substituted with one or more substituents selected from Rd, 4- to 12-membered heterocyclyl optionally substituted with one or more substituents selected from Re, and 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rf;
A1 is independently selected from the group consisting of a halogen atom and cyano;
A2 is independently selected from the group consisting of a halogen atom, cyano, amino, C1-C6 alkylamino, di(C1-C6 alkyl)amino, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C3-C10 cycloalkyl, and C1-C6 alkoxy;
A3 independently is selected from the group consisting of a halogen atom, cyano, amino, C1-C6 alkylamino, di(C1-C6 alkyl)amino, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C3-C10 cycloalkylsulfonyl, C3-C10 cycloalkyl, and C1-C6 alkoxy;
Ra is independently selected from the group consisting of a halogen atom, hydroxy, C1-C6 alkoxy, cyano, (C1-C6 alkoxy)carbonyl, carboxy, (C1-C6 alkoxy)carbonylamino, (C1-C6 alkyl)carbonylamino, amino, C1-C6 alkylamino, di(C1-C6 alkyl)amino, aminocarbonyl, (C1-C6 alkyl)aminocarbonyl, di(C1-C6 alkyl)aminocarbonyl, C1-C6 alkylsulfonylamino, C3-C10 cycloalkylsulfonylamino, di(C1-C6 alkyl)phosphono, C7-C14 aralkyl, C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Rg, C6-C10 aryl optionally substituted with one or more substituents selected from Rh, 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rg, and 4- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Rg;
Rb is independently selected from the group consisting of a halogen atom, hydroxy, C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, C1-C6 alkoxy optionally substituted with one or more substituents selected from Ra, cyano, (C1-C6 alkoxy)carbonyl, carboxy, —NR21R22, —CONR23R24, di(C1-C6 alkyl)phosphono, C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Rg, C6-C10 aryl optionally substituted with one or more substituents selected from Rh, 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rg, and 3- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Rg;
Rc, Re and Rf are independently selected from the group consisting of a halogen atom, hydroxy, cyano, carboxy, —NR21R22, —CONR23R24, —N?CH—R25, C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, (C1-C6 alkoxy)C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, (C1-C6 alkyl)carbonyl optionally substituted with one or more substituents selected from Ra, (C1-C6 alkoxy)carbonyl, (C6-C10 aryl)carbonyl optionally substituted with one or more substituents selected from Rh, (C3-C10 cycloalkyl)carbonyl optionally substituted with one or more substituents selected from Rg, (3- to 12-membered non-aromatic heterocyclyl)carbonyl optionally substituted with one or more substituents selected from Rg, C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Rg, 3- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Rg, aminocarbonyl, (C1-C6 alkyl)aminocarbonyl optionally substituted with one or more substituents selected from Ra, di(C1-C6 alkyl)aminocarbonyl optionally substituted with one or more substituents selected from Ra, [(C1-C6 alkyl)aminocarbonyl]C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, [di(C1-C6 alkyl)aminocarbonyl]C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rg, C1-C6 alkylsulfonyl optionally substituted with one or more halogen atoms, C3-C10 cycloalkylsulfonyl optionally substituted with one or more substituents selected from Rg, (C6-C10 aryl)sulfonyl optionally substituted with one or more substituents selected from Rh, C7-C14 aralkylsulfonyl, (3- to 12-membered non-aromatic heterocyclyl)sulfonyl optionally substituted with one or more substituents selected from Rg, 5- to 10-membered heteroarylcarbonyl optionally substituted with one or more substituents selected from Rg, 5- to 10-membered heteroarylsulfonyl optionally substituted with one or more substituents selected from Rg, aminosulfonyl, C1-C6 alkylaminosulfonyl, di(C1-C6 alkyl)aminosulfonyl, di(C1-C6 alkyl)phosphono, and oxo;
Rd is independently selected from the group consisting of a halogen atom, hydroxy, cyano, carboxy, —NR21R22, —CONR23R24, C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, (C1-C6 alkoxy)C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, (C1-C6 alkyl)carbonyl optionally substituted with one or more substituents selected from Ra, (C1-C6 alkoxy)carbonyl, (C6-C10 aryl)carbonyl optionally substituted with one or more substituents selected from Rh, (C3-C10 cycloalkyl)carbonyl optionally substituted with one or more substituents selected from Rg, (3- to 12-membered non-aromatic heterocyclyl)carbonyl optionally substituted with one or more substituents selected from Rg, C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Rg, 3- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Rg, aminocarbonyl, (C1-C6 alkyl)aminocarbonyl optionally substituted with one or more substituents selected from Ra, di(C1-C6 alkyl)aminocarbonyl optionally substituted with one or more substituents selected from Ra, [(C1-C6 alkyl)aminocarbonyl]C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, [di(C1-C6 alkyl)aminocarbonyl]C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rg, C1-C6 alkylsulfonyl optionally substituted with one or more halogen atoms, C3-C10 cycloalkylsulfonyl optionally substituted with one or more substituents selected from Rg, (C6-C10 aryl)sulfonyl optionally substituted with one or more substituents selected from Rh, C7-C14 aralkylsulfonyl, (3- to 12-membered non-aromatic heterocyclyl)sulfonyl optionally substituted with one or more substituents selected from Rg, 5- to 10-membered heteroarylsulfonyl optionally substituted with one or more substituents selected from Rg, aminosulfonyl, C1-C6 alkylaminosulfonyl, di(C1-C6 alkyl)aminosulfonyl, and di(C1-C6 alkyl)phosphono;
Rg is independently selected from the group consisting of nitro, hydroxy, C1-C6 alkyl optionally substituted with one or more halogen atoms, C1-C6 alkoxy optionally substituted with one or more halogen atoms, a halogen atom, amino, cyano, C1-C6 alkylamino optionally substituted with one or more hydroxy groups, di(C1-C6 alkyl)amino optionally substituted with one or more hydroxy groups, C3-C10 cycloalkylamino, (C1-C6 alkyl)carbonyl, (C1-C6 alkoxy)carbonyl, C1-C6 alkylsulfonyl, C3-C10 cycloalkylsulfonyl, C7-C14 aralkyl optionally substituted with one or more substituents selected from Ri, C6-C10 aryl optionally substituted with one or more substituents selected from Ri, C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Ri, 3- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Ri, 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Ri, and oxo;
Rh is independently selected from the group consisting of nitro, hydroxy, C1-C6 alkyl optionally substituted with one or more halogen atoms, C1-C6 alkoxy optionally substituted with one or more halogen atoms, a halogen atom, amino, cyano, C1-C6 alkylamino, di(C1-C6 alkyl)amino, C1-C6 alkylcarbonyl, (C1-C6 alkoxy)carbonyl, (C1-C6 alkoxy)carbonylamino, N—(C1-C6 alkoxy)carbonyl-N—(C1-C6 alkyl)amino, C1-C6 alkylsulfonyl, C3-C8 cycloalkylsulfonyl, C7-C14 aralkyl optionally substituted with one or more substituents selected from Ri, C6-C10 aryl optionally substituted with one or more substituents selected from Ri, C3-C8 cycloalkyl optionally substituted with one or more substituents selected from Ri, 3- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Ri, and 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Ri;
Ri is independently selected from the group consisting of nitro, hydroxy, C1-C6 alkyl optionally substituted with one or more substituents selected from a halogen atom and hydroxy, a halogen atom, amino, cyano, C1-C6 alkylamino, di(C1-C6 alkyl)amino, C1-C6 alkylcarbonyl optionally substituted with one or more substituents selected from phenyl and hydroxy, (C1-C6 alkoxy)carbonyl optionally substituted with one or more substituents selected from phenyl and hydroxy, C1-C6 alkylsulfonyl, C3-C8 cycloalkylsulfonyl, C1-C6 alkylsulfonylamino, C3-C8 cycloalkylsulfonylamino, and oxo;
R21 is selected from the group consisting of a hydrogen atom, C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, C6-C10 aryl optionally substituted with one or more substituents selected from Rh, 4- to 12-membered heterocyclyl optionally substituted with one or more substituents selected from Rg, 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rg, (C1-C6 alkoxy)carbonyl optionally substituted with one or more substituents selected from Ra, (C1-C6 alkyl)carbonyl optionally substituted with one or more substituents selected from Ra, (C3-C10 cycloalkyl)carbonyl, (C6-C10 aryl)carbonyl optionally substituted with one or more substituents selected from Rh, (3- to 12-membered non-aromatic heterocyclyl)carbonyl optionally substituted with one or more substituents selected from Rg, (5- to 10-membered heteroaryl)carbonyl optionally substituted with one or more substituents selected from Rg, aminocarbonyl, (C1-C6 alkyl)aminocarbonyl optionally substituted with one or more substituents selected from Ra, di(C1-C6 alkyl)aminocarbonyl optionally substituted with one or more substituents selected from Ra, C1-C6 alkylsulfonyl optionally substituted with one or more halogen atoms, C7-C14 aralkyl sulfonyl, C3-C10 cycloalkylsulfonyl, aminosulfonyl, C1-C6 alkylaminosulfonyl, di(C1-C6 alkyl)aminosulfonyl, and di(C1-C6 alkyl)phosphono;
R22 is selected from the group consisting of a hydrogen atom, and C1-C6 alkyl optionally substituted with one or more substituents selected from Ra;
R23 is selected from the group consisting of a hydrogen atom, C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, [(C1-C6 alkyl)amino]C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, [di(C1-C6 alkyl)amino]C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Rg, C6-C10 aryl optionally substituted with one or more substituents selected from Rh, 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rg, and 3- to 12-membered non-aromatic heterocyclyl optionally substituted with one or more substituents selected from Rg;
R24 is selected from the group consisting of a hydrogen atom, and C1-C6 alkyl optionally substituted with one or more substituents selected from Ra;
R25 is selected from the group consisting of C1-C6 alkyl optionally substituted with one or more substituents selected from Ra, C3-C10 cycloalkyl optionally substituted with one or more substituents selected from Rc, C6-C10 aryl optionally substituted with one or more substituents selected from Rd, 4- to 12-membered heterocyclyl optionally substituted with one or more substituents selected from Re, and 5- to 10-membered heteroaryl optionally substituted with one or more substituents selected from Rf;
R7 is selected from the group consisting of a hydrogen atom, a halogen atom, C1-C6 alkyl, and C1-C6 alkoxy;
R8 is selected from the group consisting of a hydrogen atom, a halogen atom, C1-C6 alkyl, and C1-C6 alkoxy; and
wherein a sulfur atom included in heterocyclyl or heteroaryl may be oxidized to be SO or SO2.

US Pat. No. 10,508,108

TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES

1. A compound of formula (I):
wherein A is —C(R1)? or —N?, and R1 is hydrogen or hydroxyl;
X is a polycyclic ring selected from the group consisting of:

B is —C(R9)(R10)—, —N(R10)—, —O—, —S— or —S(O)2—;
D is —C(R4)(R5)—, —N(R5)—, —O— or —S—;
m is 0 or 1; n is 0 or 1; p is 0 or 1; q is 0 or 1;
the E ring is a C3-6carbocyclic ring or a 3-6 membered saturated, partially unsaturated or aromatic heterocyclic ring containing 1-2 heteroatoms independently selected from O, S and N;
the E ring is optionally substituted with one to four substituents independently selected from Rb;
and optionally, the E ring is further fused to another 4-6 membered carbocyclic ring;
R is selected from the group consisting of:
(1) halogen,
(2) —CN, and
(3) —(C?O)t—Ra, wherein t is 0 or 1;
R2 and R3 together form an oxo; or alternatively, each occurrence of R2 and R3 is independently selected from the group consisting of:
(1) hydrogen,
(2) C1-6alkyl, and
(3) —O—C1-6alkyl;
each occurrence of R4, R6, R7, R9, R11 and R12 is independently selected from the group consisting of:
(1) halogen,
(2) —CN, and
(3) —(C?O)t—Ra, wherein t is 0 or 1;
each occurrence of R5 and R10 is independently selected from the group consisting of:
(1) hydrogen, and
(2) C1-6alkyl;
R8 is selected from the group consisting of:
(1) hydrogen,
(2) —CN, and
(3) C1-6alkyl;
each occurrence of Ra is independently selected from the group consisting of:
(1) hydrogen,
(2) —(O)t—Rd, wherein t is 0 or 1; Rd is selected from the group consisting of (a) hydrogen, (b) C1-6alkyl, (c) C3-7cycloalkyl, and (d) phenyl;
wherein each of the C1-6alkyl of (b) and C3-7cycloalkyl of (c) is optionally substituted with one to four substituents independently selected from Rb,
(3) —NRxRy, wherein each of Rx and Ry is independently selected from the group consisting of (a) hydrogen, (b) C1-6alkyl, (c) C3-6cycloalkyl, (d) —O—C1-6alkyl, (e) phenyl optionally substituted with one to four halogens, and (f) heterocyclyl;
wherein the C1-6alkyl of (b) is optionally substituted with one to four substituents independently selected from halogen, —O—C1-4alkyl, C3-6cycloalkyl, and heterocyclyl; and
the C3-6cycloalkyl of (c) is optionally substituted with one to four substituents independently selected from halogen, —O—C1-4alkyl, C3-6cycloalkyl, heterocyclyl, and C1-4alkyl, which is optionally substituted with one to four halogens,
the heterocyclyl of (f) is optionally substituted with one to four substituents independently selected from halogen, C1-4alkyl, —O—C1-4alkyl, C3-6cycloalkyl, and heterocyclyl;
(4) C2-6alkenyl, optionally substituted with one to four substituents independently selected from Rb,
(5) C5-6cycloalkenyl, optionally substituted with one to four substituents independently selected from Rb,
(6) aryl, optionally substituted with one to four substituents independently selected from Rb, and
(7) heterocyclyl, optionally substituted with one to four substituents independently selected from Rb;
each occurrence of Rb is independently selected from the group consisting of:
(1) halogen,
(2) —CN,
(3) oxo,
(4) —(O)t—Rd, wherein t is 0 or 1; Rd is selected from the group consisting of (a) hydrogen, (b) C1-6alkyl, (c) C3-7cycloalkyl, and (d) heterocyclyl;
wherein the C1-6alkyl of (b) is optionally substituted with one to four substituents independently selected from (i) halogen, (ii) hydroxyl, (iii) —O—C1-6alkyl, (iv) C3-6 cycloalkyl optionally substituted with 1-3 halogens, (v) —NRxRy, wherein each of Rx and Ry is independently selected from the group consisting of hydrogen, C1-6 alkyl, C3-6cycloalkyl, phenyl optionally substituted with one to four halogens, and heterocyclyl, and (vi) heterocyclyl;
the C3-7cycloalkyl of (c) is optionally substituted with one to four substituents independently selected from (i) halogen, and (ii) C1-6alkyl, which is optionally substituted with one to four halogens, and (iii) —CN; and
the heterocyclyl of (d) is optionally substituted with one to four substituents independently selected from (i) halogen, (ii) hydroxyl, (iii) oxo, (iv) C1-6alkyl optionally substituted with one to four halogens, (v) —O—C1-6alkyl, (vi) heterocyclyl optionally substituted with halogen or hydroxyl, and (vii) —NRjRk;
wherein each of Rj and Rk is independently selected from the group consisting of hydrogen and C1-6alkyl;
(5) —(C?O)t—Rc, wherein t is 0 or 1; Rc is selected from the group consisting of hydrogen, hydroxyl, C1-6alkyl, C2-6alkenyl, —O—C1-6alkyl, —NRxRy, and heterocyclyl;
wherein each of Rx and Ry is independently selected from the group consisting of (a) hydrogen, (b) C1-6alkyl, (c) C2-6alkenyl, (d) C3-6cycloalkyl, (e) phenyl optionally substituted with one to four halogens, and (f) heterocyclyl;
wherein the C1-6alkyl of (b) is optionally substituted with one to four substituents independently selected from halogen, —O—C1-4alkyl, C3-6cycloalkyl, heterocyclyl, and —(C?O)—NRjRk, wherein each of Rj and Rk is independently hydrogen or C1-6alkyl;
the C3-6cyclolkyl of (d) is optionally substituted with one to four substituents independently selected from halogen and C1-4alkyl, which is optionally substituted with one to four halogens, and
the heterocyclyl of (f) is optionally substituted with one to four substituents independently selected from halogen, —CN, C1-6alkyl, and —O—C1-6alkyl;
(6) C2-6alkenyl; and
(7) phenyl, optionally substituted with one to four substituents independently selected from halogen, C1-6alkyl, and —O—C1-6alkyl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,508,107

MORPHOLINE DERIVATIVE

Hoffmann-La Roche Inc., ...

1. A compound of formula I:
which is a 5-ethyl-4-methyl-N-[4-[(2S) morpholin-2-yl]phenyl]-1H-pyrazole-3-carboxamide, or a pharmaceutically suitable acid addition salt thereof.

US Pat. No. 10,508,105

INDAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION

Vanderbilt University, N...

1. A compound of the following formula:
wherein:
X1A: CH, CR1, or N;
each R2 is optionally present, independent and chosen from H, D, NH2, CF3, halogen, F, alkyl, Me, or CD3;
R6 is H, CH3 or CD3;
R7 is O or —CO—;
R8 is a bond, alkyl, —NH—, —O—, alkyl-O—;
R9 is substituted or unsubstituted and chosen from cycloalkyl, tetrahydrofuran, 1,4 dioxane, cyclobutyl, tetrahydropyran; and
n is 0-6;
or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable derivative thereof.

US Pat. No. 10,508,104

6-HYDROXY-5-(PHENYL/HETEROARYLSULFONYL)PYRIMIDIN-4(1H)-ONE AS APJ AGONISTS

Bristol-Myers Squibb Comp...

1. A compound of Formula (I):
or a stereoisomer, an enantiomer, a diastereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein
ring A is independently selected from C3-6 cycloalkyl, —(CH2)0-1-5- or 6-membered aryl and heterocyclyl comprising carbon atoms and 1-4 heteroatoms selected from N, NR3a, O, and S, each substituted with 1-3 R3 and 1-2 R5; provided R3 and R5 are not both H;
ring B is independently selected from C3-6 cycloalkyl, C3-6 cycloalkenyl, aryl, bicyclic carbocyclyl, 6-membered heteroaryl, 6-membered heterocyclyl, and bicyclic heterocyclyl, each substituted with 1-3 R1;
R1 is independently selected from H, F, Cl, Br, NO2, —(CH2)nORb, (CH2)nS(O)pRc, —(CH2)nC(?O)Rb, —(CH2)nNRaRa, —(CH2)nCN, —(CH2)nC(?O)NRaRa, —(CH2)nNRaC(?O)Rb, —(CH2)nNRaC(?O)NRaRa, —(CH2)nNRaC(?O)ORb, —(CH2)nOC(?O)NRaRa, —(CH2)nC(?O)ORb, —(CH2)nS(O)pNRaRa, —(CH2)nNRaS(O)pNRaRa, —(CH2)nNRaS(O)pRc, C1-4alkyl substituted with 0-3 Re, —(CH2)n—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)n-heterocyclyl substituted with 0-3 Re;
R2 is independently selected from C1-5 alkyl substituted with 0-3 Re; C2-5 alkenyl substituted with 0-3 Re, aryl substituted with 0-3 Re, heterocyclyl substituted with 0-3 Re, and C3-6 cycloalkyl substituted with 0-3 Re; provided when R2 is C1-5 alkyl, the carbon atom except the one attached to the pyrimidine ring may be replaced by O, N, and S;
R3 is independently selected from H, F, Cl, Br, C1-5 alkyl substituted with 0-3 Re, —(CH2)nORb, —(CH2)nNRaRa, —(CH2)nCN, —(CH2)nC(?O)Rb, —(CH2)nC(?O)ORb, —(CH2)nC(?O)NRaRa, —(CH2)nNHC(?O)Rb, —(CH2)nNHC(?O)NRaRa, —(CH2)nNHC(?O)ORb, —(CH2)nNHS(O)pNRaRa, —(CH2)nNHS(O)pRe—(CH2)nS(O)pRe, —(CH2)nS(O)pNRaRa, and —(CH2)nOC(?O)NRaRa;
R3a is independently selected from H, C1-5 alkyl substituted with 0-3 Re, —S(O)pRc, —C(?O)Rb, —C(?O)NRaRa, —C(?O)ORb, S(O)pNRaRa, R6, —S(O)pR6, —C(?O)R6, —C(?O)NRaR6, —C(?O)OR6, and —S(O)pNRaR6;
R4 is independently selected from H, C1-5 alkyl substituted with 0-3 Re, C2-5 alkenyl substituted with 0-3 Re, (CH2)n—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)n-heterocyclyl substituted with 0-3 Re;
R5 is independently selected from H, R6, —OR6, —S(O)pR6, —C(?O)R6, —C(?O)OR6, —NRaR6, —C(?O)NRaR6, —NRaC(?O)R6, —NRaC(?O)OR6, —OC(?O)NRaR6, —S(O)pNRaR6, —NRaS(O)pNRaR6, and —NRaS(O)pR6;
R6 is independently selected from —(CR7R7)n-aryl, —(CR7R7)n—C3-6 cycloalkyl, and —(CR7R7)n-heteroaryl, each substituted with 1-6 R8;
R7 is independently selected from H, C1-4 alkyl, and (CH2)n—C3-12 carbocyclyl substituted with 0-3 Re;
R8 is independently selected from H, F, Cl, Br, —(CH2)nCN, —(CH2)nORb, —(CH2)nC(?O)Rb, —(CH2)nC(?O)ORb, —(CH2)nC(?O)NRaRa, —(CH2)nNRaRa, —(CH2)nNRaC(?O)Rb, —(CH2)nNRaC(?O)ORb, —(CH2)nNRaC(?O)NRaRa, —(CH2)nOC(?O)NRaRa, —(CH2)nS(O)pRc, —(CH2)nS(O)pNRaRa, —(CH2)nNRaS(O)pNRaRa, —(CH2)nNRaS(O)pRe, C1-4 alkyl substituted with 0-3 Re, (CH2)n—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)n-heterocyclyl substituted with 0-3 Re;
Ra is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)n—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)n-heterocyclyl substituted with 0-5 Re; or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 Re;
Rb is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)n—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)n-heterocyclyl substituted with 0-5 Re;
Re is independently selected from C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, C3-6carbocyclyl, and heterocyclyl;
Re is independently selected from C1-6 alkyl substituted with 0-5 Rf, C2-6 alkenyl, C2-6 alkynyl, —(CH2)n—C3-6 cycloalkyl, —(CH2)nC4-6 heterocyclyl, —(CH2)n-aryl, —(CH2)n-heteroaryl, F, Cl, Br, CN, NO2, ?O, CO2H, —(CH2)nORf, S(O)pRf, C(?O)NRfRf, NRfC(?O)Rf, S(O)pNRfRf, NRfS(O)pRf, NRfC(?O)ORf, OC(?O)NRfRf, and —(CH2)nNRfRf;
Rf is independently selected from H, F, Cl, Br, CN, OH, C1-5alkyl (optimally substituted with F, Cl, Br and OH), C3-6 cycloalkyl, and phenyl, or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C1-4alkyl;
n is independently selected from zero, 1, 2, 3, and 4; and
p is independently selected from zero, 1, and 2.

US Pat. No. 10,508,103

BENZIMIDAZOLE-LINKED INDOLE COMPOUND ACTING AS NOVEL DIVALENT IAP ANTAGONIST

MEDSHINE DISCOVERY INC., ...

30. A pharmaceutical composition comprising an effective amount of the compound or the pharmaceutically acceptable salt thereof of claim 1.

US Pat. No. 10,508,099

ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF

Samumed, LLC, San Diego,...

1. A compound, or a pharmaceutically acceptable salt thereof, of Formula I:
wherein:
R1, R2, R4, and R5 are independently selected from the group consisting of H, halide, unsubstituted —(C1-3 haloalkyl), and unsubstituted —(C1-3 alkyl);
R3 is a 5-membered heteroaryl optionally substituted with 1-4 R45;
with the proviso that R3 is not

R6 is selected from the group consisting of —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R36, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R37, —(C1-4 alkylene)N(R46)(R47), —N(R48)(R49), —CF(C1-9 alkyl)2, —(C1-4 alkylene)pO(C3-9 alkyl), and —(C2-9 alkynyl) optionally substituted with one or more halides; wherein each alkyl of —CF(C1-9 alkyl)2 is, independently, optionally substituted with one or more halides; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
with the proviso that R6 is not unsubstituted —(CH2)tetrahydropyranyl;
each R36 is independently selected from the group consisting of halide, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), —(C1-4 alkylene)pOR42, —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R43, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R44, —C(?O)(R50), —(C1-4 alkylene)C(?O)OR51, —(C1-4 alkylene)aryl optionally substituted with one or more halides, —(C1-4 alkylene)pheteroaryl optionally substituted with one or more halides, and —SO2(R52); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
alternatively, two R36 attached to the same carbon atom can together represent ?O to form a carbonyl group;
each R37 is independently selected from the group consisting of halide, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), —(C1-4 alkylene)pOR42, —N(R53)2, —C(?O)(R50), —C(?O)OR51, —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R43, and —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R44; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
each R38 independently is selected from the group consisting of halide, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), —CN, and —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R44; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
each R39 is independently selected from the group consisting of halide, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), —CN, and —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R44; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
each R40 is independently selected from the group consisting of halide, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), —CN, and —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R44; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
each R41 is independently selected from the group consisting of halide, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), and —CN;
each R42 is independently selected from the group consisting of H, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), and —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R44; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
each R43 is independently selected from the group consisting of halide, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), —CN, and —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R44; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
each R44 is independently selected from the group consisting of halide, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), and —CN;
each R45 is independently selected from the group consisting of H, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), —N(R53)2, —(C1-4 alkylene)pOR42, —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R38, and -carbocyclyl optionally substituted with 1-12 R39; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
alternatively, two adjacent R45 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R40 and -carbocyclyl optionally substituted with 1-12 R41;
R46 is attached to the nitrogen and is selected from the group consisting of H, unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R38, and -carbocyclyl optionally substituted with 1-12 R39; wherein —(C1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;
R47 is attached to the nitrogen and is selected from the group consisting of unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R38, and -carbocyclyl optionally substituted with 1-12 R39; wherein —(C1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;
R48 is attached to the nitrogen and selected from the group consisting of H, unsubstituted —(C15 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), and unsubstituted —(C1-5 haloalkyl);
R49 is attached to the nitrogen and is selected from the group consisting of —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R38, and —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R39; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
R50 is selected from the group consisting of H, unsubstituted —(C3-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), —(C1-4 alkylene)paryl optionally substituted with one or more halides or unsubstituted —(C1-5 alkyl), —(C1-4 alkylene)pheteroaryl optionally substituted with one or more halides or unsubstituted —(C1-5 alkyl), and —(C1-4 alkylene)pheterocyclyl optionally substituted with one or more halides or one or more unsubstituted —(C1-5 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
R51 is selected from the group consisting of H, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), —(C1-4 alkylene)paryl optionally substituted with one or more halides or unsubstituted —(C1-5 alkyl), —(C1-4 alkylene)pheteroaryl optionally substituted with one or more halides or unsubstituted —(C1-5 alkyl), and —(C1-4 alkylene)pheterocyclyl optionally substituted with one or more halides or one or more unsubstituted —(C1-5 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;
R52 is selected from the group consisting of unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), —(C1-4 alkylene)paryl optionally substituted with one or more halides or unsubstituted —(C1-5 alkyl), —(C1-4 alkylene)pheteroaryl optionally substituted with one or more halides or unsubstituted —(C1-5 alkyl), and —(C1-4 alkylene)pheterocyclyl optionally substituted with one or more halides or one or more unsubstituted —(C1-5 alkyl); wherein —(C1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;
each R53 is independently selected from the group consisting of H, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), and unsubstituted —(C2-5 alkynyl);
each p is independently 0 or 1;
with the proviso that Formula I is not a structure selected from the group consisting of:

wherein each heterocyclyl is independently a nonaromatic cyclic ring system comprising at least one heteroatom in the ring system backbone.

US Pat. No. 10,508,097

ANTIBACTERIAL COMPOUNDS AND USES THEREOF

The Global Alliance for T...

1. A compound of formula (I):
including any stereochemically isomeric form thereof,
wherein:
R1 is phenyl, optionally mono- or bi-substituted independently with lower alkyl, halogen or alkoxy,
5- or 6-membered heteroaryl, optionally mono-, bi- or tri-substituted independently with lower alkyl, halogen, alkoxy, —SCH3, —SCH2CH3, —N(CH2CH3)2 or —N(CH3)2,
benzofurany,
2,3-dihydrobenzo [b][1,4]dioxin-5-yl,
2,3-dihydro-1H-inden-4-yl or
5,6,7,8-tetrahydro naphthalene-1-yl;
R2 and R3, independently of each other, are hydrogen or lower alkyl;
R4 is
5- or 6-membered heteroaryl mono-, bi- or tri-substituted independently with alkoxy, —O-cycloalky, —S-loweralkyl, difluoromethoxy or —N(CH3)2,
benzofuranyl,
benzo[b]thiophenyl or
2,3-dihydro-1H-indenyl; and
R5 is halogen or cyano,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,508,093

COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING A SYMPTOM ASSOCIATED WITH GOUT OR HYPERURICEMIA

ARTHROSI THERAPEUTICS, IN...

1. A method of treating hyperuricemia or gout in a mammal, comprising administering to the mammal a therapeutically effective amount of a compound of Formula 1, or a pharmaceutically acceptable salt thereof:
wherein:
X is —OH, —F, or —Cl; and
R1, R2, R3, R4 and R5 are each independently selected from a group consisting of H, deuterium, and F;
wherein at least one of R1, R2, R3, R4, and R5 is deuterium.

US Pat. No. 10,508,091

PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION

THE NATIONAL INSTITUTE FO...

1. A compound of general formula (Id):
wherein
L2 is a linking group selected from the group consisting of 4-hydroxybutanamidylene having the formula HO—CH2—C*H—CH2—C(O)NH—, wherein the asterisk denotes an attachment point and pyrrolidine-2,5-dionylene;
Z is C1-2-perfluoroalkoxy, and Y is halogen;
or an enantiomer, diastereomer, mixture or salt thereof.

US Pat. No. 10,508,090

SULFONAMIDES AS GPR40- AND GPR120-AGONISTS

1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof,
wherein:
A is a mono or di-carbocyclic residue, optionally partially or totally unsaturated, comprising carbon atoms and optionally one or more heteroatoms selected from N, S and O;
R1, R2, and R3 are independently selected from the group consisting of —H, -halogen, —CF3, —CN, —CH2CN, —OMe, —OCF3, —OH, phenyl, —OPh, —OCH2Ph, —OCH2OMe, —OCH2CN—NO2, —NR?R?, linear or branched C1-C6 alkyl, —O(CH2)p—S(O)2Me and a five-membered ring heterocycle;
wherein R? and R? are independently —H or C1-C4 alkyl;
wherein phenyl and the five-membered ring heterocycle are independently unsubstituted or substituted with a group selected from the group consisting of linear or branched C1-C4 alkyl, halogen, —OMe and —OH;
p is 1 to 4;
X is —CH2 or —C(O);
n is 0, 1 or 2;
R4 is —Y—C(O)OH, wherein Y is a straight chain C4-C18 hydrocarbon, saturated or unsaturated; and
R4 is in position meta or para on the aromatic ring;
wherein when A is phenyl, n is 0, and Y is a C4 hydrocarbon, at least one of said R1, R2, R3 is not hydrogen;
wherein when A is phenyl, n is 0, Y is a C4 hydrocarbon, and R1 and R2 are hydrogen, R3 is not Cl in position para on the aromatic ring.

US Pat. No. 10,508,089

USE OF N-(1,3,4-OXADIAZOL-2-YL)ARYLCARBOXAMIDES OR THEIR SALTS FOR CONTROLLING UNWANTED PLANTS IN AREAS OF TRANSGENIC CROP PLANTS BEING TOLERANT TO HPPD INHIBITOR HERBICIDES

BASF SE, Ludwigshafen am...

1. A method for controlling unwanted plants comprising applying an N-(1,3,4-Oxadiazol-2-yl)arylcarboxamide of formula (I) or a salt thereof
wherein
X is methyl,
Y is SO2CH3, and
Z is CF3,to a transgenic crop plant that is tolerant to an HPPD inhibitor herbicide by containing one or more chimeric gene(s), wherein the one or more chimeric gene(s) comprisesa DNA sequence derived from Pseudomonas fluorescens encoding a hydroxyphenylpyruvate dioxygenase (HPPD) selected from the group consisting of SEQ ID NO: 25, SEQ ID NO: 27, and SEQ ID NO: 29.

US Pat. No. 10,508,084

METHOD FOR PRODUCING 4,4,7-TRIFLUORO-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE COMPOUND AND INTERMEDIATE USED IN THE METHOD

TACURION, Bridgewater, N...

1. A method of increasing the yield of a compound represented by formula (I)comprising converting a compound represented by formula (5) into the compound represented by formula (I)wherein the conversion of the compound represented by formula (5) does not include the use of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride as a reagent.

US Pat. No. 10,508,081

INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES

Pfizer Inc., New York, N...

1. A method for synthesizing a compound of Formula I
wherein R12 is selected from straight and branched-chain C1-C8 alkyl;
each R10 is independently selected from hydrogen, R12 and —OR12;
R8 and R9 are each independently selected from hydrogen and straight and branched-chain C1-C8 alkyl, wherein each said alkyl for R8 and R9 is independently optionally substituted by —NH2, —NHR11, —NR11R13, —OR11, —OH, or —SR11, wherein each R11 and each R13 are independently selected from straight and branched-chain C1-C5 alkyl;
r is an integer 0 or 1;
G is oxygen or sulfur;
Z1 is H or straight or branched-chain C1-C5 alkyl;
Ar is 1,2-, 1,3-, or 1,4-phenylene optionally substituted with one, two or three groups independently selected from straight or branched-chain C1-C6 alkyl, —OR14, —SR14, halogen, nitro, —COOR14, —C(?O)NHR14, —O(CH2)nCOOR14, —S(CH2)nCOOR14, —O(CH2)nC(?O)NHR14, and —S(CH2)nC(?O)NHR14, or Ar is a 1,2-, 1,3-, 1,4-, 1,5-, 1,6-, 1,7-, 1,8-, 2,3-, 2,6-, or 2,7-naphthylidene optionally substituted with one, two, three, or four groups independently selected from straight or branched-chain C1-C6 alkyl, —OR14, —SR14, halogen, nitro, —COOR14, —C(?O)NHR14, —O(CH2)nCOOR14, —S(CH2)nCOOR14, —O(CH2)nC(?O)NHR14, and —S(CH2)nC(?O)NHR14;
wherein each R14 is independently selected from (C1-C5)alkyl and each R14 is independently optionally substituted with one or two groups selected from —OH, —(C1-C4)alkyl, and —S(C1-C4)alkyl;
each n is an integer independently selected from 0, 1, 2, 3, 4, and 5;
W is selected from —O—, —S—, —C(?O)NH—, —NHC(?O)—, and —NR15—, wherein R15 is a (C1-C5)alkyl and R15 is optionally substituted with one or two groups selected from —OH, —(C1-C4)alkyl, and —S(C1-C4)alkyl; and Y is a straight or branched-chain (C1-C6)alkylene group or a straight or branched-chain (C2-C6)alkenylene group; which method comprises reacting a compound of Formula II

with a compound of Formula III

US Pat. No. 10,508,080

PROCESS FOR THE PREPARATION OF ISOSULFAN BLUE

Apicore US LLC, Canonbur...

1. A process of preparing isosulfan blue sodium salt, said process comprising:i) combining isoleuco acid of the formula (4):

with an oxidizing agent,
ii) recovering isosulfan blue acid, and
iii) obtaining isosulfan blue sodium salt therefrom.

US Pat. No. 10,508,078

COMPOUND, PHOTOPOLYMERIZATION INITIATOR COMPRISING SAID COMPOUND, AND PHOTOSENSITIVE RESIN COMPOSITION CONTAINING SAID PHOTOPOLYMERIZATION INITIATOR

TOKYO UNIVERSITY OF SCIEN...

1. A compound of formula (1):
wherein in formula (1),
R1 is a hydrogen atom, a hydroxyl group, an alkoxy group having a carbon number of 1 to 18 or an organic group selected from the group consisting of an alkyl group having a carbon number of 1 to 18, an alkenyl group having a carbon number of 2 to 18, an alkynyl group having a carbon number of 2 to 18, an aryl group having a carbon number of 6 to 12, an acyl group having a carbon number 1 to 18, an aroyl group having a carbon number of 7 to 18, a nitro group, a cyano group, an alkylthio group having a carbon number of 1 to 18, and a halogen atom,
when there is a plurality of R1, each R1 may be the same or different from each other;
R2, R3, R5, and R6 each independently is a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having a carbon number of 1 to 18, a mercapto group, a sulfide group, a silyl group, a silanol group, a nitro group, a nitroso group, a cyano group, a sulfino group, a sulfo group, a sulfonato group, a phosphino group, a phosphinyl group, a phosphono group, a phosphonato group, an amino group, an ammonio group, or an organic group selected from the group consisting of an alkyl group having a carbon number of 1 to 20, an aryl group having a carbon number of 6 to 20, an aralkyl group, a halogenated alkyl group, an isocyano group, a cyanate group, an isocyanato group, a thiocyanato group, an isothiocyanato group, an alkoxycarbonyl group, a carbamoyl group, a thiocarbamoyl group, a carboxyl group, a carboxylate group, an acyl group having a carbon number of 1 to 20, an acyloxy group, and a hydroxyimino group;
R2 and R3 on the same benzene ring may be connected to form a ring structure;
R5 and R6 on the same benzene ring may be connected to form a ring structure;
R4 each independently is an organic group selected from the group consisting of an alkyl group having a carbon number of 1 to 20 containing a thioether bond, an aryl group having a carbon number of 6 to 20 containing a thioether bond, an aralkyl group containing a thioether bond, a halogenated alkyl group containing a thioether bond, an isocyano group containing a thioether bond, a cyanate group containing a thioether bond, an isocyanato group containing a thioether bond, a thiocyanato group containing a thioether bond, an isothiocyanato group containing a thioether bond, an alkoxycarbonyl group containing a thioether bond, a carbamoyl group containing a thioether bond, a thiocarbamoyl group containing a thioether bond, a carboxyl group containing a thioether bond, a carboxylate group containing a thioether bond, an acyl group containing a thioether bond, an acyloxy group having an acyl group containing a thioether bond, and a hydroxyimino group containing a thioether bond;
X is a residue being a saturated hydrocarbon including a ring structure having a 3- to 10-membered ring from which n hydrogen atoms are removed; and
n is an integer of 1 to 6.

US Pat. No. 10,508,077

ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS

FORMA Therapeutics, Inc.,...

1. A compound of Formula (Ia):
or a pharmaceutically acceptable salt thereof,
wherein
A is hydrogen;
het is a 3-to-12 membered heterocycle, wherein said heterocycle is optionally substituted with one or more Rd;
each Rd is independently hydrogen, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, cyano, oxo, C3-C8 cycloalkyl, 3-to-12 membered heterocycloalkyl, aryl, heteroaryl, —(CH2)nRe, —(CH2)nO(CH2)mRe, —(CH2)nNReRf, —C(O)(CH2)nRe, —(CH2)nC(O)ORe, —C(O)(CH2)nSRe, —(CH2)nC(O)NReRf, —NH(CH2)nRe, —NHC(O)(CH2)nRe, —NHC(O)(CH2)nORe, —NHC(O)(CH2)nSRe, —NHS(O)2Re, —ORe, or —S(O)2Re, wherein each alkyl, haloalkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally substituted with one or more Re or Rf;
or two Rd when attached to the same carbon atom can form a C5-C12spirocycle or a 3- to 12-membered spiroheterocycle, wherein the spirocycle or the spiroheterocycle are optionally substituted with one or more Re or Rf;
each Re is independently hydrogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C3-C8 cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —C(O)(CH2)nRf, or —(CH2)nC(O)Rf, wherein each alkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally substituted with one or more Rf;
each Rf is independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, cyano, oxo, cycloalkyl, 3-to-12 membered heterocycloalkyl, aryl, heteroaryl, (C1-C6)alkylaryl, halogen, —(CH2)nO(CH2)mCH3, —(CH2)nN(CH3)2, —(CH2)nO(CH2)mN(CH3)2, —(CH2)nNReRf, —N(CH3)S(O)2CH3, —S(CH2)mCH3, or —S(O)2(CH2)mCH3, wherein each alkyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally substituted with one or more alkyl, haloalkyl, alkoxy, haloalkoxy, cyano, oxo, halogen, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
n is 0, 1, 2, 3, or 4; and
m is 0, 1, 2, 3, or 4.

US Pat. No. 10,508,076

METHOD FOR RESOLUTION OF CITALOPRAM INTERMEDIATE 5-CYANO DIOL

Zhejiang huahai Pharmaceu...

1. A crystal form of the resolved intermediate of formula III,characterized in that the DSC thermogram obtained from differential scanning calorimetry (heating rate 10° C./minute) shows an endothermic peak, which is onset 135.20° C., peak 150.85° C.

US Pat. No. 10,508,075

PROCESS FOR PREPARATION OF TRIENTINE DIHYDROCHLORIDE

1. A process comprising preparing Trientine dihydrochloride directly and selectively in a single step reaction consisting of reacting a compound of Formula (6) with 1.6 to 2.1 molar equivalents of hydrochloric acid in an aqueous medium to produce the Trientine dihydrochloride without formation of Trientine tetrahydrochloride

US Pat. No. 10,508,066

METHODS AND SYSTEMS OF UPGRADING HEAVY AROMATICS STREAM TO PETROCHEMICAL FEEDSTOCK

Saudi Arabian Oil Company...

1. A process for recovery of alkyl mono-aromatic compounds, the process comprising the steps of:supplying a feed stream containing C9+ compounds from an aromatic complex to a separator to produce a first product stream containing C9 and C10 compounds and a second product stream containing one or more of heavy alkyl aromatic compounds and alkyl-bridged non-condensed alkyl multi-aromatic compounds;
supplying the first product stream containing C9 and C10 compounds to a transalkylation/toluene disproportionation process unit to yield a third product stream enriched in C8 compounds;
allowing a hydrogen stream and the second product stream to react in presence of a catalyst under specific reaction conditions in a hydrodearylation reactor to yield a fourth product stream containing one or more alkyl mono-aromatic compounds and a fifth product stream containing C11+ compounds; and
supplying the fourth product stream to the toluene transalkylation/toluene disproportionation process unit to produce alkyl mono-aromatic compounds.

US Pat. No. 10,508,063

OLEFIN OLIGOMERIZATION IN THE PRESENCE OF CYCLOPENTENE

ExxonMobil Chemical Paten...

1. A process for converting an olefin-containing hydrocarbon feed into an oligomerization product, the process comprising the steps of:(a) contacting the olefin-containing hydrocarbon feed in a reactor with an oligomerization catalyst having a deactivation rate of below 20° C. per 1,000 ton (t) of oligomerization product under conditions suitable to oligomerize the olefin to obtain a reactor effluent, the olefin-containing hydrocarbon feed comprising at least one C2 to C12 acyclic olefin and cyclopentene, the reactor effluent comprising an oligomerization product which comprises C6 to C16 cycloalkenes,
wherein the deactivation rate of the oligomerization catalyst is defined as the temperature increase needed to maintain 90% conversion of the selected at least one acyclic olefin(s) in the feed per 1,000 ton (t) oligomerization product produced pert of oligomerization catalyst; and
(b) adjusting the content of cyclopentene in the olefin-containing hydrocarbon feed to a level at or below 1.5 wt % based on the total weight of olefins in the hydrocarbon feed to maintain the deactivation rate.

US Pat. No. 10,508,061

SYNTHETIC AGRICULTURAL PRODUCT

BFP Management, LLC, Sal...

1. A synthetic agricultural product comprising:a fertilizer and/or other agricultural product comprising a number of known ions available to be exchanged, wherein the known ions do not include ammonium;
a mineral substance comprising a number of native ion exchange sites; and
an effective amount of water for maintaining the fertilizer and/or other agricultural product and the mineral substance in a suspension or solution;
wherein at least one of the known ions available to be exchanged may attach to at least one of the native ion exchange sites; and
wherein a volume of the fertilizer and/or other agricultural product and a volume of the mineral substance are such that the number of known ions available to be exchanged is at least two orders of magnitude greater than the number of native ion exchange sites.

US Pat. No. 10,508,060

FERTILIZER WITH ORGANIC POTASSIUM SALTS

NACHURS ALPINE SOLUTIONS,...

1. A fertilizer composition comprising water and a carboxylic acid salt of potassium selected from (1) CH3(CH2)xCOOK wherein x=0-4, (2) MOOC(CR1R2)xCOOK wherein R1?—H or —OH or —COOM and R2?—H or —OH or —COOM and x=0-4 and M=H or K, (3) HO(CR1R2)xCOOK wherein R1?H or a C1 to C4 alkyl group and R2?H or a C1 to C4 alkyl group and x=1-5, (4) CH3CO(CR1R2)xCOOK wherein R1?H or a C1 to C4 alkyl group and R2?H or a C1 to C4 alkyl group and x=1-3, or (5) combinations thereof, and optionally, a second potassium source selected from the group consisting of potassium phosphate, potassium hydroxide, potassium chloride, potassium thiosulfate, potassium silicate and combinations thereof, wherein the organic potassium source combined with the optional second potassium source delivers from 1% to 40% available potassium in the form of K2O in the fertilizer composition and wherein the fertilizer composition has a Storage Stability Value defined by the equation:and wherein (a) the Storage Stability Value of the fertilizer composition is less than 75 and the fertilizer composition has a pH between 5.5 and 7.7 or (b) the Storage Stability Value of the fertilizer composition is greater than 100 and the fertilizer composition has a pH between 6.0 and 9.5.

US Pat. No. 10,508,056

METHOD TO FORM SILICON CARBIDE FIBERS BY SINGLE STAGE PYROLYSIS OF POLYSILAZANE PRECURSORS

GENERAL ELECTRIC COMPANY,...

1. A method for producing a substantially crystalline, dense silicon carbide fiber having a diameter between 1 ?m and 50 ?m, said method comprising:heating an infusible polysilazane fiber
(1) in a continuous process in a single furnace with constant atmospheric condition, wherein the infusible polysilazane fiber continuously moves through the single furnace and the infusible polysilazane fiber is heated at a continuous ramp rate;
(2) to a maximum temperature between 1750° C. and 2150° C.;
(3) the infusible polysilazane fiber is heated at the maximum temperature for a time between 1 minute and 15 minutes;
whereby said infusible polysilazane fiber is converted to a substantially crystalline, dense silicon carbide fiber.

US Pat. No. 10,508,053

IMAGE GUIDE FIBER

Sumita Optical Glass, Inc...

1. An image guide fiber comprising a plurality of cores and a clad which is common to the plurality of cores, whereinthe cores and the clad are each made of multi-component glass,
the image guide fiber has a numerical aperture NA in the range of 0.70 to 0.90,
a linear thermal expansion coefficient difference ??, which is a value obtained by subtracting a linear thermal expansion coefficient ?2 at from 100° C. to 300° C. of a clad glass of the clad, from a linear thermal expansion coefficient ?1 at from 100° C. to 300° C. of a core glass of the cores, is in the range of ?3×10?7/° C. to 15×10?7/° C.,
a glass-transition temperature Tg1 of the core glass is higher than a glass-transition temperature Tg2 of the clad glass,
in a section of the image guide fiber, a core occupancy area ratio is 25% or more, where the core occupancy area ratio is a ratio of a total area of the plurality of cores to an area of a screen portion defined by an outer circumferential edge of the clad, and
in the section of the image guide fiber, a pixel density is 0.1 pixel/?m2 or more, where the pixel density is the number of pixels per unit area of the screen portion.

US Pat. No. 10,508,052

TUBE GLASS CUTTING METHOD AND CUTTING DEVICE, AND TUBE GLASS PRODUCT MANUFACTURING METHOD

NIPPON ELECTRIC GLASS CO....

1. A method of cutting a tube glass, comprising:irradiating the tube glass with laser light having a focal point adjusted to an inside of the tube glass, to thereby form an inner crack region including one or more cracks in a portion of the tube glass in a circumferential direction of the tube glass through multiphoton absorption that occurs in an irradiation region of the laser light; and
generating, in the tube glass, a stress that urges the one or more cracks in the inner crack region to propagate in the circumferential direction of the tube glass to cause the one or more cracks to propagate throughout an entire circumference of the tube glass, to thereby cut the tube glass.

US Pat. No. 10,508,051

LENS FORMING MOLD AND MANUFACTURING METHOD FOR CYLINDRICAL LENS

FANUC CORPORATION, Yaman...

1. A manufacturing method for a plurality of cylindrical lenses using a lens forming mold for forming, from a glass material formed into a circular plate shape, a molding on which a plurality of cylindrical surfaces are arranged in parallel, the lens forming mold comprising:a first mold comprising: a plurality of cylindrical surface forming portions that are arranged in parallel at equal intervals; and a first flat surface forming portion that is provided between adjacent cylindrical surface forming portions; and
a second mold comprising a second flat surface forming portion that sandwiches the glass material and faces the plurality of cylindrical surface forming portions and the first flat surface forming portion of the first mold when the molding is molded,
wherein the first mold and the second mold are each formed into a cylindrical shape that has a circular molding surface,
the method comprising the steps of:
placing a glass material formed into a circular plate shape on the first mold and joining the first mold and the second mold to thereby form, without performing centering, a molding on which a plurality of cylindrical surfaces are arranged in parallel; and
cutting the molding with a cutting tool in two directions, the two directions being a direction in which the plurality of cylindrical surfaces are arranged and a direction that intersects with the direction in which the plurality of cylindrical surfaces are arranged, to thereby obtain the plurality of cylindrical lenses from one molding.

US Pat. No. 10,508,050

PROCESS AND FACILITY FOR THE TREATMENT OF LIVESTOCK WASTE

1. A facility for treating a daily volume of livestock waste water, comprisinga) a collecting basin for continually collecting and stirring raw livestock liquid wastes;
b) a pretreatment channel having an inlet end and an outlet end, capable to contain at least said daily volume of waste water, connected at said inlet end with said collecting basin and accepting said raw wastes, which flow through the channel and form a pretreated waste water while allowing for partial settling of dispersed solids and enriching the lower part of the channel with said solids relatively to the upper part;
c) an anaerobic reactor connected with said channel at said outlet end and accepting said pretreated waste water from the upper part of said channel in separate batches through a connecting pipe, each batch allowed to react in the reactor and partially settle, forming anaerobically treated waste water being enriched with solids in the lower part of the reactor relatively to the upper part, wherein a portion of said anaerobically treated waste water from said lower part is fed to said channel at said inlet end where it combines with said raw wastes, said connecting pipe being branched to enable a part of said pretreated waste water to flow to an aerobic stirred reactor;
d) the aerobic stirred reactor connected with said anaerobic reactor and accepting said anaerobically treated water from the upper part of said anaerobic reactor in separate batches, each batch allowed to react in the aerobic reactor and partially settle, forming aerobically treated waste water being enriched with solids in the lower part of the aerobic reactor relatively to the upper part, wherein a portion of said aerobically treated waste water from said lower part is fed back to said anaerobic reactor, and said aerobically treated water from the upper part being removed as a safe water product, the aerobic reactor connected to said connecting pipe, which pipe is provided with a valve enabling to divide the flow of said pretreated waste water from the upper part of said channel between said anaerobic reactor and said aerobic reactor; and
e) a compost basin to which cellulose based solid waste is fed, connected with said pretreatment channel at said outlet end and accepting said pretreated waste water from the lower part of said channel, the basin provided with mixing means, whereby providing a quality compost;wherein said daily volume of livestock waste water is converted to a quality compost and safe water for release into municipal system or for use in agriculture.

US Pat. No. 10,508,047

ULTRAVIOLET LIGHT WATER TREATMENT SYSTEM FOR BATHING UNITS

Gecko Alliance Group Inc....

1. An ultraviolet (UV) water treatment system for use in treating water in a spa system, the spa system including a receptacle for holding water and a circulation system for removing and returning water from and to the receptacle, said UV water treatment system being configured to be installed in a space under a spa skirt of the spa system, said UV water treatment system comprising:a reactor unit configured to be positioned in fluid communication with the circulation system of the spa system for allowing water from the receptacle to flow through the reactor unit as the circulation system removes and returns water from and to the receptacle, the reactor unit comprising:
a tubular housing having a first end portion and a second end portion;
a first end cap disposed at the first end portion of the housing, the first end cap comprising an inlet for receiving water into the housing;
a second end cap disposed at the second end portion of the housing, the second end cap comprising an outlet for expelling water out of the housing;
a UV light source disposed within the housing and configured to radiate UV light into the housing; and
a plurality of fasteners engaging and extending between the first end cap and the second end cap to secure the first end cap and the second end cap to the reactor unit;
a power unit configured to power the UV light source, the power unit comprising an enclosure disposed at the first end portion of the reactor unit, the power unit enclosure holding:
a socket connectedly receiving the UV light source; and
a ballast connected to the socket, the enclosure of the power unit configured to hold the ballast laterally adjacent to the socket within the enclosure;
a mounting fixture disposed at the first end portion of the tubular housing of the reactor unit between the reactor unit and the power unit enclosure, the mounting fixture being configured for facilitating mounting of the UV water treatment system to the spa system.

US Pat. No. 10,508,044

SYSTEM AND METHOD FOR WATER PURIFICATION

Cloudburst International,...

1. A system for use in water purification comprising:a high temperature water tank having a first water inlet, a second water inlet, a first water outlet and a second water outlet;
a flameless heat source having an inlet connected to the second water outlet of the high temperature water tank and an outlet connected to the second water inlet of the high temperature water tank;
a cylindrical vessel disposed within the high temperature water tank, the cylindrical vessel having an overflow chamber, an underflow chamber, an inlet chamber disposed between the overflow chamber and the underflow chamber, a first outlet connected to the overflow chamber, an inlet connected to the inlet chamber, and a second outlet connected to the underflow chamber;
disposed within the cylindrical vessel, a first set of hydrocyclones, at least one intermediate set of hydrocyclones, and a final set of hydrocyclones, the sets of hydrocyclones separated by dividers wherein the hydrocyclones within each set are arranged in a parallel configuration and operate in parallel, and the sets of hydrocyclones are arranged in series,
and wherein each hydrocyclone has a tangential inlet disposed within the inlet chamber of the cylindrical vessel and in fluid communication with the inlet connected to the inlet chamber, an overflow disposed within the overflow chamber of the cylindrical vessel and an underflow disposed within the underflow chamber of the cylindrical vessel;
a first pump connected to the first outlet of the high temperature water tank and the inlet of the cylindrical vessel;
a steam production meter connected to the first outlet of the cylindrical vessel; and
a steam condenser and heat exchanger having a steam inlet and a purified water outlet, wherein the steam inlet is connected to the steam production meter.

US Pat. No. 10,508,043

THERMAL DESALINATION FOR INCREASED DISTILLATE PRODUCTION

Massachusetts Institute o...

1. A method for thermal-based desalination, comprising a feed routing including a series of preheaters for flow of a liquid feed; brine routings for flow of concentrated brine from the liquid feed; vapor routings for vapor generated from the liquid feed; a series of multi-effect distillation effects, each of the effects coupled with at least one routing selected from the feed routing and the brine routings and with one of the vapor routings; and a series of brine flash boxes coupled with at least one routing selected from the feed routing and the brine routings and with one of the vapor routings, the method comprising:flowing a liquid feed through the feed routing and using the preheaters to heat the liquid feed in the feed routing;
using at least one of a plurality of splitters between preheaters to selectively direct at least one of (a) a first portion of the flow of the liquid feed from the feed routing through at least one of the multi-effect distillation effects in the series of multi-effect distillation effects and (b) a second portion of the flow of the liquid feed through a subsequent preheater in the series of preheaters, and to shift allocation of the flow between the first portion and the second portion, wherein the first portion of the liquid feed flows into an inlet of a first effect, where the feed liquid is heated to produce vapor that is directed through at least one of the vapor routings and brine that is directed through at least one of the brine routings;
flowing a first part of the vapor produced in at least one effect from one of the vapor routings through at least one of the preheaters to transfer heat from the vapor to the liquid feed in the feed routing;
flowing a second part of the vapor produced in the at least one effect from another of the vapor routings to a subsequent effect in the series;
flowing brine produced in each effect from at least one of the brine routings through a brine flash box and heating the brine to release additional vapor and produce a concentrated brine that is directed through another of the brine routings; and
using additional splitters, each of which is downstream of a flash box in the series of brine flash boxes in at least one of the brine routings, to selectively direct the concentrated brine from each flash box into at least one of (a) a first stream that is directed through one of the brine routings to another flash box in the series of brine flash boxes and (b) a second stream that is directed through another of the brine routings into another effect.

US Pat. No. 10,508,042

PROCESS AND INSTALLATION FOR PRODUCING ALUMINA TRIHYDRATE BY ALKALINE DIGESTION OF BAUXITE ORE

Rio Tinto Alcan Internati...

1. A process for producing alumina trihydrate by digestion of bauxite ore comprising:(a) a digestion step for digesting the bauxite ore with a sodium aluminate liquor to obtain a slurry including an enriched sodium aluminate liquor comprising dissolved alumina and insoluble residues formed of particles of undissolved bauxite ore;
(b) a separation step for treating the slurry to separate the enriched sodium aluminate liquor from the insoluble residues to produce a clarified liquor; and
(c) a precipitation step for treating the clarified liquor to precipitate alumina trihydrate,characterized in that the separation step (b) includes:b1) pretreating the slurry, in a pre-treatment step, by adding a flocculant to the slurry and mixing the flocculant and the slurry to obtain a flocculated slurry,
b2) settling the flocculated slurry in a gravity settler vessel to produce the clarified liquor and a thickened slurry of the insoluble residues,
b3) determining a measured value representative of a concentration of solid particles in the clarified liquor, in a measurement step,
b4) comparing the measured value with a predetermined threshold of the concentration of the solid particles in the clarified liquor,
b5) feeding the clarified liquor directly to the precipitation step when the measured value is less than the predetermined threshold of the concentration of the solid particles in the clarified liquor, and
b6) redirecting the clarified liquor to the pre-treatment step b1) when the measured value is more than the predetermined threshold of the concentration of the solid particles in the clarified liquor.

US Pat. No. 10,508,041

ANHYDROUS, AMORPHOUS AND POROUS MAGNESIUM CARBONATES AND METHODS OF PRODUCTION THEREOF

Disruptive Materials AB, ...

1. A magnesium carbonate, wherein the magnesium carbonate is X-ray amorphous and is anhydrous, and wherein the magnesium carbonate has an incremental pore volume in cm3/g that has a maximum value of less than 0.08 cm3/g for pores with a diameter of 30 nm or less, and wherein the incremental pore volume is measured by nitrogen adsorption, and wherein the magnesium carbonate with pores with a diameter of 30 nm or less is 83% of the magnesium carbonate powder.

US Pat. No. 10,508,040

METHODS OF MAKING SILICA NANOPARTICLES, PROPELLANTS, AND SAFETY DEVICES

KING ABDULLAH UNIVERSITY ...

1. A method of making silica particles, comprising:mixing nitric acid with porous silicon particles in an environment, wherein the porous silicon particles are irregularly shaped; and
forming spherical non-aggregated silica particles.

US Pat. No. 10,508,037

METHOD FOR CONTINUOUSLY PREPARING GRAPHENE OXIDE NANOPLATELET

1. A method of continuously preparing graphene oxide nanoplatelet, characterized in that: the method comprises the steps of:providing a graphite raw material selected from the group consisting of flexible graphite paper coil material, flexible graphite strip material and carbon fiber wire material;
through driving the graphite raw material by a feeding device, sequentially processing a two-step treatment of electrochemical intercalation and electrolytic oxidation exfoliation respectively;
obtaining a graphene oxide nanoplatelet which is dispersed in electrolyte; and
processing treatment of filtering, washing and drying and then obtaining a graphene oxide powder material.

US Pat. No. 10,508,035

ALUMINUM NITRIDE POWDERS

TOKUYAMA CORPORATION, Sh...

1. Aluminum nitride single crystal particles, each having a flat octahedral shape in a direction where hexagonal faces are opposed to each other, which is composed of two opposed hexagonal faces and six rectangular faces, whereinan average distance “D” between two opposed corners within each of the hexagonal faces is 19.1 to 110 ?m, a length “L” of the short side of each of the rectangular faces is 2 to 45 ?m, and L/D is 0.05 to 0.33; each of the hexagonal faces and each of the rectangular faces cross each other to form a curve without forming a single ridge; and the true density is 3.20 to 3.26 g/cm3.

US Pat. No. 10,508,034

EXTENDED THERMAL STAGE SULFUR RECOVERY PROCESS

Saudi Arabian Oil Company...

1. An apparatus for recovering sulfur from an acid gas stream, the apparatus comprising:a reaction furnace, the reaction furnace configured to contain a reaction between hydrogen sulfide in the acid gas stream and oxygen in an air feed to produce a reaction effluent, where the reaction furnace operates at a minimum reaction temperature, where the reaction effluent comprises elemental sulfur;
an extended boiler stage, where the extended boiler stage comprises:
a wasteheat stage, the wasteheat stage fluidly connected to the reaction furnace, the wasteheat stage configured to capture heat energy from a reaction effluent to produce a cooled effluent, where the cooled effluent is at a boiler section outlet temperature, and
a catalytic extension physically connected to the wasteheat stage, the catalytic extension configured to allow a reaction to convert sulfur compounds to produce a boiler catalytic effluent, where the boiler catalytic effluent comprises elemental sulfur, where the catalytic extension comprises a catalyst section, where the catalyst section comprises a catalyst, where the boiler catalytic effluent is at a boiler catalytic effluent temperature;
a condenser fluidly connected to the catalytic extension, the condenser configured to condense the elemental sulfur to produce liquid sulfur and a gases stream;
a thermal oxidizer fluidly connected to the condenser, the thermal oxidizer configured to oxidize sulfur compounds in the gases stream and oxygen in an air stream to produce an oxidizer outlet stream, the oxidizer outlet stream comprising sulfur dioxide; and
a scrubbing unit fluidly connected to the thermal oxidizer, the scrubbing unit configured to separate the sulfur dioxide from the gases stream to produce a recycle stream and an effluent gases stream, where the recycle stream comprises the sulfur dioxide.

US Pat. No. 10,508,033

ENHANCEMENT OF CLAUS TAIL GAS TREATMENT BY SULFUR DIOXIDE-SELECTIVE MEMBRANE TECHNOLOGY

Saudi Arabian Oil Company...

1. A method for increasing sulfur recovery from an acid gas feed, the method comprising the steps of:introducing the acid gas feed and a sulfur dioxide enriched air stream to a Claus process to produce a product gas stream and a recovered sulfur stream, wherein the acid gas feed comprises hydrogen sulfide, wherein the hydrogen sulfide is present in a hydrogen sulfide concentration, wherein the sulfur dioxide enriched air stream comprises sulfur dioxide and air;
introducing the product gas stream to a thermal oxidizer to produce a flue gas stream, the thermal oxidizer configured to convert sulfur containing compounds in the product gas stream to sulfur dioxide;
introducing the flue gas stream to a membrane sweeping unit, wherein the membrane sweeping unit comprises a membrane, wherein the membrane sweeping unit is configured to produce a sulfur dioxide depleted stream, wherein the sulfur dioxide in the flue gas stream permeates the membrane of the membrane sweeping unit to a permeate side; and
introducing a sweep air stream to the permeate side, wherein the sweep air stream collects the sulfur dioxide that permeates the membrane of the membrane sweeping unit to create the sulfur dioxide enriched air stream.

US Pat. No. 10,508,032

CATALYSTS AND RELATED METHODS FOR PHOTOCATALYTIC PRODUCTION OF H2O2 AND THERMOCATALYTIC REACTANT OXIDATION

Northwestern University, ...

1. A composition comprising a nanoparticulate TiO2 core component, the nanoparticulate TiO2 core component having a surface; a SiO2 shell component coupled to and partially coating the surface of said core component; and transition metal moieties coupled to said shell component, said composition comprising pores comprising TiO2 surface areas.

US Pat. No. 10,508,031

CHLORINE DIOXIDE GENERATION

International Dioxcide, I...

1. A device comprising:(a) a reaction chamber wherein chemicals are mixed to generate chlorine dioxide;
(b) an eductor that provides a vacuum within the reaction chamber and a motive water supply to deliver chlorine dioxide into a flow chamber;
(c) the flow chamber operably connected to the reaction chamber via the motive water conduit; and
(d) a float-dependent valve that provides a second connection between the reaction chamber and flow chamber and that serves as:
i) a safety interlock that prevents chemical flow without having a sufficiently flooded flow chamber to dilute the generated chlorine dioxide, wherein the ratio of the flow chamber volume to the reaction chamber volume ensures chlorine dioxide concentration no higher than 3,000 ppm within the flow chamber;
ii) a relief vent from the reaction chamber to the flow chamber should the reaction chamber experience a higher pressure than the flow chamber; and
iii) a drainage component of the reaction chamber into the flow chamber in the absence of eductor-driven vacuum, thus preventing long-term storage of highly concentrated reactor liquor (>3,000 ppm chlorine dioxide) as well as facilitating reactor chamber maintenance or decommissioning.

US Pat. No. 10,508,028

DEVICE FOR PROTECTING FEOL ELEMENT AND BEOL ELEMENT

TAIWAN SEMICONDUCTOR MANU...

17. A semiconductor device, comprising:a complementary metal-oxide-semiconductor (CMOS) device comprising:
a semiconductor substrate;
a front-end-of-the-line (FEOL) element disposed on the semiconductor substrate;
a plurality of dielectric layers disposed on the semiconductor substrate; and
a back-end-of-the-line (BEOL) element disposed in the dielectric layers, wherein the BEOL element is laterally spaced from the FEOL element at a distance;
a first conductive shielding layer disposed on the dielectric layers and arranged to protectively cover the BEOL element, wherein the first conductive shielding layer is ground to the semiconductor substrate, and an orthogonal projection of the first conductive shielding layer on the semiconductor substrate overlaps with an orthogonal projection of the BEOL element on the semiconductor substrate;
a second conductive shielding layer disposed on the dielectric layers and arranged to protectively cover the FEOL element, wherein the second conductive shielding layer is ground to the semiconductor substrate, and an orthogonal projection of the second conductive shielding layer on the semiconductor substrate overlaps with an orthogonal projection of the FEOL element on the semiconductor substrate;
an inter-layer dielectric (ILD) layer which is disposed on and covers the first conductive shielding layer and the second conductive shielding layer; and
a micro electromechanical system (MEMS) device disposed on the ILD layer, the MEMS device comprising a MEMS element, wherein an orthogonal projection of the MEMS element on the semiconductor substrate is between orthogonal projections of the first conductive shielding layer and the second shielding conductive layer on the semiconductor substrate.

US Pat. No. 10,508,026

MONOLITHICALLY INTEGRATED MULTI-SENSOR DEVICE ON A SEMICONDUCTOR SUBSTRATE AND METHOD THEREFOR

Versana Micro Inc., Scot...

1. A monolithically integrated multi-sensor (MIMs) comprising:a first integrated circuit comprising:
a pressure sensor configured to measure a parameter; and
a first MEMs sensor configured to measure a first parameter; and
a second MEMs sensor configured to measure a second parameter wherein the the first parameter, the second parameter and the parameter measured by the microphone are different and wherein the microphone, the first MEMs sensor, and the second MEMs sensor are formed on or in a single semiconductor substrate.

US Pat. No. 10,508,025

MEMS SWITCH AND ELECTRONIC DEVICE

TDK CORPORATION, Tokyo (...

1. A MEMS switch, comprising:a first flexible member;
a first signal line provided to the first flexible member;
a first ground electrode provided to the first flexible member and adjacent to the first signal line;
a second flexible member adjacent to the first flexible member with a gap;
a second signal line provided to the second flexible member; and
a second ground electrode provided to the second flexible member and adjacent to the second signal line,
a first driving element that deforms at least the first flexible member; and
a contact terminal that is fixed to anyone of the first signal line and the second signal line and that performs connection between the first signal line and the second signal line according to the deformation of the first flexible member,
wherein the first signal line and the first ground electrode are provided on the first flexible member,
the second signal line and the second ground electrode are provided on the second flexible member,
the second ground electrode extends to be adjacent to the first signal line via a first gap, and the first signal line is located to be interposed between the first ground electrode and the second ground electrode to thereby constitute a first coplanar waveguide, and
the first ground electrode extends to be adjacent to the second signal line via a second gap, and the second signal line is located to be interposed between the second ground electrode and the first ground electrode to thereby constitute a second coplanar waveguide.

US Pat. No. 10,508,023

MEMS DEVICES INCLUDING MEMS DIES AND CONNECTORS THERETO

Taiwan Semiconductor Manu...

1. A microelectromechanical system (MEMS) device, comprising:a first MEMS device having a first cavity, the first cavity having a first pressure;
a second MEMS device having a second cavity, the second cavity having a second pressure, the second pressure being different from the first pressure, the first MEMS device and the second MEMS device overlying a first substrate;
a complementary metal-oxide-semiconductor (CMOS) die having a second substrate, the second substrate being physically separate from the first substrate;
a molding material overlying the first MEMS device, the second MEMS device, and the CMOS die, wherein the molding material extends between the first substrate and the second substrate, and wherein a first surface of the molding material comprises a plurality of recessed regions;
a first set of electrical connectors in the molding material, each of the first set of electrical connectors coupling at least one of the first MEMS device and the second MEMS device to a recessed region of the plurality of recessed regions; and
a second set of electrical connectors over the first surface of the molding material, each of the second set of electrical connectors being coupled to at least one of the first set of electrical connectors.

US Pat. No. 10,508,022

MEMS DEVICE AND PROCESS FOR RF AND LOW RESISTANCE APPLICATIONS

INVENSENSE, INC., San Jo...

1. A MEMS device comprising:a MEMS wafer including a handle wafer with a cavity, a silicon device layer that comprises silicon, a first metal conductive layer deposited directly on a surface of the silicon device layer, an electrically conductive barrier layer deposited on the first metal conductive layer, and a bonding layer deposited on the electrically conductive barrier layer, wherein at least a portion of the silicon device layer is located between the first metal conductive layer and the cavity; and
a CMOS wafer bonded to the MEMS wafer, wherein the CMOS wafer includes a second metal conductive layer such that an electrical connection is formed between the CMOS wafer and the MEMS wafer, and wherein the second metal conductive layer of the CMOS wafer mixes with the bonding layer of the MEMS wafer during a eutectic reaction to create an electrical contact to the electrically conductive barrier layer on the first metal conductive layer, wherein the electrically conductive barrier layer prevents a eutectic reaction between the first metal conducive layer and the bonding layer.

US Pat. No. 10,508,019

LISTING BEAD FOR UPHOLSTERY CLIPS

Hope Global, Division of ...

1. A listing for assembling trim covers to a foam substrate containing one or more clips comprising:a listing bead defining a cross section with a tapered shape with a bottom tip and upper barbs, and
a strip if web material affixed to the listing bead, the web material defining at least one cutout in the web, the at least one cutout in the web located in at least one position relative to the one or more clips in the foam substrate during assembly of the listing to the one or more clips.

US Pat. No. 10,508,016

CONTAINER INSERT FOR USE IN A CLOSED LOOP DISPENSING SYSTEM

1. An insert for use with a closed loop dispensing system including a container having a throat with an inside surface, comprising:a horizontally disposed ring-shaped lip having an upper side, a lower side, an outer end, and an inner end;
a generally cylindrical upper wall member having an open upper end, an open lower end, an inner surface and an outer surface;
a horizontally disposed first wall member extending inwardly from said lower end of said upper wall member with said first wall member having an inner end;
a generally cylindrical lower wall member having an open upper end, an open lower end, an inner surface and an outer surface;
said lower wall member extending downwardly from said inner end of said first wall member;
said lower wall member having at least one annular retaining member extending outwardly from said outer surface thereof;
a horizontally disposed second wall member having inner and outer ends;
said second wall member extending inwardly from said lower wall member above said lower end of said lower wall member;
said second wall member having an inner end;
a generally cylindrical and hollow first receiver tube having upper and lower ends;
said first receiver tube being vertically disposed;
said first receiver tube extending upwardly from said inner end of said second wall member;
a horizontally disposed and annular first shoulder extending inwardly from said upper end of said first receiver tube;
said first shoulder having inner and outer ends;
a generally cylindrical and hollow second receiver tube having upper and lower ends;
said second receiver tube extending upwardly from said first shoulder outwardly of said inner end of said first shoulder;
said first receiver tube defining a first passageway;
said second receiver tube defining a second passageway;
an upstanding hollow valve stem having an upper end, a lower end, an outer surface and an inner surface;
said valve stem having an upper tubular member and a lower tubular member;
said upper tubular member having a greater diameter than said lower tubular member;
a second annular shoulder, having an upper end and a lower end, extending outwardly from said valve stem between said upper and lower ends thereof;
said valve stem being vertically movably positioned in said first and second receiver tubes between upper and lower positions;
said upper end of said second annular shoulder of said valve stem being in engagement with said lower end of said first annular shoulder when said valve stem is in said upper position;
a retainer configured to be inserted into said lower open end of said lower wall member;
said retainer including a horizontally disposed disc member having a plurality of radially spaced-apart openings extending downwardly therethrough;
said disc member of said retainer having a hollow dip tube support extending downwardly therefrom;
said disc member of said retainer having a central opening formed therein;
said retainer including an elongated hollow valve body, having an open lower end and a closed upper end, which is integrally formed with said disc member;
said valve body extending upwardly from said disc member of said retainer whereby said open lower end of said valve stem is in communication with said central opening of said disc member;
said valve body having at least one opening formed therein below said closed upper end of said valve body;
a plastic spring over-molded thereon on said retainer;
said plastic spring including a hollow upper cylindrical portion having a lower end and an upper end;
said plastic spring having a horizontally disposed disc portion at said lower end of said upper cylindrical portion thereof;
said disc portion of said plastic spring having a plurality of spaced-apart hollow protrusions formed therein;
said hollow protrusions being received in said openings formed in said disc member of said retainer;
each of said hollow protrusions having an open upper end and a lower end;
each of said protrusions having a bi-directional slit-type valve formed in said lower end thereof;
said upper end of said upper cylindrical portion of said plastic spring being in engagement with said annular shoulder of said valve stem to urge said valve stem to its closed position thereby closing said opening in said upper end of said valve stem; and
said upper end of said cylindrical portion of said plastic spring being compressed downwardly upon downward force being applied to said upper end of said valve stem to open said at least one opening in said upper end of said valve.

US Pat. No. 10,508,013

METHOD FOR CLEANING AN ON-LOAD TOP CHANGER, AND ON-LOAD TAP CHANGER

MASCHINENFABRIK REINHAUSE...

1. A method of cleaning an on-load tap changer in a control transformer, where the on-load tap changer comprises a movable contact and a fixed contact, the method comprising the steps of sequentially:generating a switching signal for actuating the on-load tap changer;
thereafter checking at least one cleaning parameter; and
thereafter generating a cleaning signal as a function of the switching signal and in a manner depending on the result of the checking of the one cleaning parameter;
thereafter rubbing the movable contact against the fixed contact in a manner determined by the cleaning signal; and
thereafter actuating the on-load tap changer as a function of the switching signal.

US Pat. No. 10,508,012

UNIVERSAL SYNCHRONIZED CAPPING MACHINE

PSR AUTOMATION INC., Sha...

1. An apparatus for automatically applying threaded caps to threaded necks of containers of varying designs comprising:a. a cap delivery module comprising a cap chute, and a cap foot adapted to present caps to the top of the container;
b. a container conveyor module comprising a horizontally oriented conveyor driven by a first motor coupled to a first shaft, said horizontally oriented conveyor having a first side and a second side, a first gripper belt assembly mounted adjacent the first side of said horizontally oriented conveyor, a second gripper belt assembly mounted adjacent the second side of said horizontally oriented conveyor, each of said first and second gripper belt assemblies comprising a lower vertically oriented gripper belt and an upper vertically oriented gripper belt, a second motor coupled to a second shaft and adapted to simultaneously drive the lower vertically oriented gripper belt and the upper vertically oriented gripper belt, and a third motor coupled to a third shaft adapted to alter the distance between the lower vertically oriented gripper belt and an upper vertically oriented gripper belt, said conveyor module further comprising a fourth motor coupled to a fourth shaft operable to alter the distance between the first gripper belt assembly and the second gripper belt assembly;
c. a modular torque assembly comprising a fifth motor and a fifth shaft for adjusting the height of the modular torque assembly relative to the horizontally oriented conveyor of the container conveyor module, a cap restraint, and at least one torque module comprising a first torque unit and a second torque unit, each of said first and second torque units comprising a sixth motor and a torque wheel coupled to the sixth motor by a sixth shaft driven by the sixth motor, said at least one torque module further comprising a seventh motor coupled to a seventh shaft adapted to alter the distance between the torque wheels of the first and second torque units; and
d. a controller operated under program control adapted to independently and automatically control the operation of the first motor to control the speed of the horizontally oriented conveyor, the second motor of the first gripper belt assembly to control the speed of the lower vertically oriented gripper belt and the upper vertically oriented gripper belt of the first gripper belt assembly, the second motor of the second gripper belt assembly to control the speed of the lower vertically oriented gripper belt and the upper vertically oriented gripper belt of the second gripper belt assembly, the third motor of the first gripper belt assembly to control the distance between the lower vertically oriented gripper belt and an upper vertically oriented gripper belt of the first gripper belt assembly, the third motor of the second gripper belt assembly to control the distance between the lower vertically oriented gripper belt and an upper vertically oriented gripper belt of the second gripper belt assembly, the fourth motor to control the distance between the first gripper belt assembly and the second gripper belt assembly, the fifth motor to control the height of the modular torque assembly relative to the horizontally oriented conveyor of the container conveyor module, the sixth motor of the first torque unit of said at least one torque module to control the speed and torque of the wheel of said first torque unit, the sixth motor of the second torque unit of said at least one torque module to control the speed and torque of the wheel of said second torque unit, and the seventh motor to control the distance between the torque wheels of the first and second torque units.

US Pat. No. 10,508,011

FILTER TUBE INSTALLATION APPARATUS

TCT INNOVATIONS LLC, Wal...

1. A filter tube installation apparatus for use with a vehicle to install a palletized filter tube, the apparatus comprising:at least one vertical beam attachable to the vehicle, at least one retention bar attached to the at least one vertical beam, and a roller cage assembly attached to the at least one vertical beam;
the roller cage assembly comprising at least one cage beam forming a cage, a plurality of rollers mounted on the inner periphery of the cage, and a mounting member attached to the cage;
wherein the at least one retention bar may be translated from a lowered position to a raised position.

US Pat. No. 10,508,009

VEHICLE STORAGE AREA LIFT ASSEMBLY

For Global Technologies, ...

1. A lift assembly for a utility vehicle storage area, comprising:a floor supported by a scissor mechanism;
an actuator for raising said scissor mechanism and said floor from a neutral position to an elevated position;
at least two members attached to an underside of said floor, wherein said at least two members include a first pair of members attached adjacent a rear edge of said floor and a second pair of members attached apart from said first pair of members between a front edge and the rear edge of said floor;
guide members attached to said scissor mechanism and within which said at least two members move; and
a detent movable between an extended position wherein a portion of said detent protrudes into said guide member and contacts one of said at least two members sufficient to resist movement of said at least two members and a retracted position wherein said at least two members freely move within said guide members.

US Pat. No. 10,508,008

PNEUMATIC JACKING ASSEMBLY

1. A pneumatic jacking assembly being configured to selectively lift a vehicle, said assembly comprising:an air bag being configured to be selectively inflated, said air bag having a top edge, a bottom edge and an outer wall extending therebetween, said outer wall having a plurality of intersecting sides such that said air bag has a cubic shape;
a first plate being coupled to said air bag, said first plate being configured to be positioned on a support surface such that said first plate is positioned beneath a vehicle;
a second plate being coupled to said air bag wherein said second plate is configured to abut the vehicle when said air bag is inflated thereby facilitating said air bag to lift the vehicle for servicing the vehicle, said second plate having a primary surface, a secondary surface and a perimeter edge extending therebewteen, said top edge of said air bag being bonded to said secondary surface such that said top edge forms a fluid impermeable seal with said secondary surface, said top edge being coextensive with said perimeter edge of said second plate, said primary surface having a plurality of grooves wherein each of said grooves is configured to frictionally engage the vehicle thereby inhibiting the vehicle from sliding on said primary surface, each of said grooves being linear and extending perpendicularly between opposite sides of said perimeter edge of said second plate, said grooves being spaced apart from each other and being distributed along said primary surface;
a pump being coupled to said first plate, said pump being in fluid communication with an interior of said air bag, said pump inflating said air bag when said pump is turned on, said second plate being urged away from said first plate when said air bag is inflated wherein said second plate is configured to lift the vehicle; and
a power supply being electrically coupled to said pump, said power supply comprising a power cord extending away from said first plate, said power cord having a negative line and a positive line, each of said negative line and said positive line having a distal end with respect to said pump.

US Pat. No. 10,508,007

HEIGHT-ADJUSTMENT DEVICE AND METHOD FOR OPERATING AN AGITATING DEVICE

UTS BIOGASTECHNIK GMBH, ...

1. A height adjusting device for adjusting the height of at least one agitating device in a digester of a biogas plant comprising at least one support unit, wherein the agitating device is accommodated on the support unit along which it can be displaced upwardly and downwardly, at least one housing unit, at least one drum device rotatably accommodated at the housing unit and at least one displacement member,wherein the displacement member is coupled at a first end to the drum device and is coupled at an opposing end to the agitating device and wherein rotation of the drum device causes the displacement member to be at least partially be wound onto the drum device or unwound from the drum device, causing the agitating device to be displaced upwardly or downwardly depending on the direction of rotation of the drum device,
and at least one fixing device, wherein the fixing device comprises at least one disk device and at least one brake, wherein the at least one brake engages with the disk device to fix the drum device at least temporarily to inhibit the displacement member at least from unwinding if the displacement member is not retained tautly between the drum device and the agitating device, wherein the at least one brake is retained on the housing unit and is pivotable relative to the drum device and/or the disk device.

US Pat. No. 10,508,004

LATERAL TRANSFER STATION FOR ELEVATOR HAVING A MAGNETIC SCREW PROPULSION SYSTEM

OTIS ELEVATOR COMPANY, F...

1. An elevator system comprising:an elevator car for travel in a hoistway;
a stator positioned along the hoistway; and
a magnetic screw assembly coupled to the car, the magnetic screw assembly coacting with the stator to impart motion to the elevator car;
the stator including a service section having a plurality of poles to coact with the magnetic screw assembly;
the stator including a transfer station section, the transfer station section of the stator including a plurality of stator permanent magnets.

US Pat. No. 10,508,002

ROPE LIFTING TOOL AND A ROPE LIFTING ARRANGEMENT

KONE CORPORATION, Helsin...

1. A rope lifting tool for belt-shaped ropes comprising:a first guide for guiding the rope lifting tool along a first guide rail;
a second guide for guiding the rope lifting tool along a second guide rail;
an upright plate extending in a vertical direction and including a front surface and a back surface;
an inclined plate including a front surface and a back surface, wherein an entirety of the inclined plate is at an acute angle relative to the upright plate, the upright plate and the inclined plate having a wedge shaped space between them and the front surface of the upright plate overlaps the entirety of the inclined plate and extends beyond the inclined plate in the vertical direction and in a horizontal direction, the horizontal direction being perpendicular to the vertical direction;
a plurality of wedge members placed adjacent each other inside the wedge-shaped space and in contact with the back surface of the inclined plate and the front surface of the upright plate; and
a plurality of guide bolts,
wherein each guide bolt extends only through a respective elongated aperture of the inclined plate into a respective wedge member, each elongated aperture has a substantially oblong shape, and each guide bolt is movable along a length of the respective elongated aperture to alter a vertical position of the respective wedge member,
wherein the back surface of the inclined plate faces the front surface of the upright plate,
wherein the plurality of wedge members are spaced apart in the horizontal direction,
wherein a rope gap for receiving an end of a belt-shaped rope is formed directly between each wedge member and the upright plate, which rope gap is narrowable by wedging of the wedge member in the wedge shaped space,
wherein the first and second guides are configured to slide along the first and second guide rails, respectively, to provide lateral support for the rope lifting tool,
wherein the entirety of the first and second guides are spaced from the upright plate and from the inclined plate, and
wherein each of the upright plate and the inclined plate are substantially planar.

US Pat. No. 10,508,001

ELEVATOR SYSTEM

Mitsubishi Electric Corpo...

1. An elevator system comprising:a first car that moves vertically;
an elongated object that moves as the first car moves;
a second car that moves vertically;
a detector provided on the second car in order to detect a position of the elongated object; and
circuitry to detect, on the basis of the position detected by the detector, that abnormal swaying requiring a control operation is occurring in the elongated object.

US Pat. No. 10,507,999

MANUFACTURING METHOD OF TANK AND TANK MANUFACTURING APPARATUS

Toyota Jidosha Kabushiki ...

8. A tank manufacturing apparatus, comprising:a fiber bundle supplier that is configured to supply a resin-adhering fiber bundle that has a resin adhering to a fiber bundle;
a cooling assembly that is configured to cool down the resin-adhering fiber bundle supplied from the fiber bundle supplier; and
a fiber winding assembly that is configured to wind the resin-adhering fiber bundle that is cooled down by the cooling assembly, on a rotating liner, wherein
the fiber winding assembly winds the resin-adhering fiber bundle on the liner to form a reinforcement layer on an outer circumference of the liner,
the cooling assembly is configured to cool down both the resin-adhering fiber bundle that forms an inner layer portion of the reinforcement layer and the resin-adhering fiber bundle that forms an outer layer portion of the reinforcement layer,
the cooling assembly is configured to cool down the resin-adhering fiber bundle to make a temperature of the resin-adhering fiber bundle equal to or lower than a set temperature prior to the resin-adhering fiber bundle being wound on the rotating liner, the set temperature being set in advance as a temperature to provide a viscosity of the resin that prevents the resin from being splashed from the resin-adhering fiber bundle by rotation of the liner in a course of winding the resin-adhering fiber bundle on the liner, and
the cooling assembly is configured to cool down both the resin-adhering fiber bundle that forms the inner layer portion of the reinforcement layer and the resin-adhering fiber bundle that forms the outer layer portion of the reinforcement layer by allowing both of the resin-adhering fiber bundles to come into contact alternately with an upper outer circumference and a lower outer circumference of multiple cooled joint rollers.

US Pat. No. 10,507,998

SHEET PROCESSING APPARATUS AND IMAGE FORMING APPARATUS

Canon Kabushiki Kaisha, ...

1. An image forming apparatus comprising:a first photosensitive member;
a second photosensitive member;
an intermediate transfer belt, onto which toner images on the first photosensitive member and the second photosensitive member are transferred, the intermediate transfer belt being supported by a rotatable supporting roller;
a transfer portion configured to transfer the toner images on the intermediate transfer belt onto a sheet fed from a container containing sheets;
a fixing portion configured to fix the toner images, which are transferred onto the sheet by the transfer portion, to the sheet;
a first stacking portion on which the sheet, on which the toner images are fixed by the fixing portion, is stacked;
a first binding unit configured to bind sheets stacked on the first stacking portion using a staple;
a second binding unit configured to bind sheets stacked on the first stacking portion without using a staple;
a discharge portion configured to discharge a bound sheet bundle from the first stacking portion in a discharge direction; and
a second stacking portion on which the sheet bundle discharged by the discharge portion is stacked,
wherein the first binding unit is disposed above the intermediate transfer belt, and a first vertical plane parallel to an axis of the supporting roller intersects the first binding unit and the intermediate transfer belt,
wherein the second binding unit is disposed above the intermediate transfer belt, and a second vertical plane parallel to the axis of the supporting roller intersects the second binding unit and the intermediate transfer belt,
wherein an upstream end of the second stacking portion in the discharge direction is located between the first photosensitive member and the first binding unit in a horizontal direction orthogonal to the axis of the supporting roller, and
wherein the upstream end of the second stacking portion in the discharge direction is located between the first photosensitive member and the second binding unit in the horizontal direction orthogonal to the axis of the supporting roller.

US Pat. No. 10,507,997

DISPENSER FOR DISPENSING A TWO-LAYER ADHESIVE TAPE, AND METHOD FOR PRODUCING A TWO-LAYER ADHESIVE TAPE

TESA SE, Norderstedt (DE...

1. A dispenser configured for dispensing a strip of a first adhesive tape that is adhesive on both sides and on one side is covered with a liner, the dispenser comprising:a first storage unit from which the first adhesive tape is drawn off;
a second storage unit from which a second adhesive tape is drawn off;
a connection installation by means of which the first adhesive tape and the second adhesive tape are interconnected to form a two-ply adhesive tape;
an application installation by means of which the two-ply adhesive tape as a composite is capable of being applied to a substrate; and
a storage roll that is capable of being driven by a drive installation that is synchronized with the drawing-off movement of the first adhesive tape, of the second adhesive tape, or the two-ply adhesive tape is provided, wherein
the liner which has been drawn off from the two-ply adhesive tape is wound onto said storage roll.

US Pat. No. 10,507,996

SUPPLY ROLL WITH FUNCTIONAL MARKER, METHOD FOR HANDLING FLAT MATERIAL AND/OR STRIP MATERIAL WOUND ONTO SUPPLY ROLLS, AS WELL AS SYSTEM FOR HANDLING FLAT MATERIAL AND/OR STRIP MATERIAL

Krones Aktiengesellschaft...

1. A method for handling flat material and/or strip material (8) wound onto a supply roll (5), comprising:applying at least one adhesive marker (3) in a position onto an externally arranged free end section (7) of the flat material and/or strip material (8) on a supply roll (5), wherein the at least one adhesive marker (3) comprises a transparent window (24) through which an end edge (18) of the externally arranged free end section (7) is visible;
positioning the supply roll (5) on a retaining mandrel (15);
optically identifying the position of the at least one functional marker (2);
aligning the free end section (7) based on the optical identification step; and
extracting the free end section (7) from the supply roll (5).