US Pat. No. 10,364,584

WAVE GENERATOR SYSTEM WITH A LATERAL MOVING WAVE BARRIER FOR THE GENERATION OF WAVES IN TWO AREAS OF WATER

INSTANT SPORT, S.L, Dono...

1. Wave generator system (1), characterised in that it comprises:a continuous and elongated barrier (4), arranged along a longitudinal direction (5), and having a front side (4a) and a rear side (4b) along a length (L) of the barrier (4), where the front side (4a) is facing a first mass of water (2) and the rear side (4b) is facing a second mass of water (3), wherein the barrier (4) prevents the passage of water between the first mass of water (2) and the second mass of water (3), through, above and under the barrier (4) and along the length (L);
a first reef (12) formed in a floor (6) beneath the first mass of water (2) and at a distance from the front side (4a), and a second reef (15) formed in a floor (8) beneath the second mass of water (3) and at a distance from the rear side (4b), wherein
the barrier (4) is movable along the whole of the length (L) with a serpentine movement, wherein the front side (4a) pushes water of the first mass of water (2) towards the first reef (12) for the formation of a wave (W) in the first mass of water (2), whilst the rear side (4b) pushes water from the second mass of water (3) towards the second reef (15) for the formation of a wave (W) in the second mass of water (3).

US Pat. No. 10,364,583

DEPLOYABLE SELF-SUSTAINING SHELTER

1. A structure comprising:an expandable structural frame adapted to expand to an expanded condition and retract to a retracted condition, wherein the expandable structural frame comprises a first frame member and a second frame member, said first and second frame members telescopically connected to one another for expansion and retraction of the structure;
a first electrical flow path adapted for providing electrical power to the structure in the expanded condition;
a second electrical flow path adapted for providing electrical power to the structure in the retracted condition, said second electrical flow path different from the first electrical flow path;
an electrically conductive switching device, said electrically conductive switching device comprising a caster carriage dongle, in a fixed position with respect to the first frame member and adapted to maintain moving contact with the second frame member during expansion and retraction of the structure; and
an expandable HVAC system including primary ductwork, secondary ductwork, and tertiary ductwork, wherein the primary ductwork, secondary ductwork, and tertiary ductwork are adapted to together define an expanded configuration and a retracted configuration;
wherein the expandable HVAC system defines a first fluid pathway in the expanded configuration and a second fluid pathway in the retracted conditions, said second fluid pathway being different from the first fluid pathway.

US Pat. No. 10,364,582

DEVICE FOR REPAIRING CRACK IN WALL

SAKAEGUMI CORPORATION, T...

1. A device for repairing a crack in a wall comprising:an injection nozzle that has a nozzle part, with a front end adapted to be positioned on a crack in a wall and adapted to inject filler into the crack, and an inflow pipe that is connected to the nozzle part and sends filler to the nozzle part,
an adsorption disk that is fixed to a supporting shaft in which a suction passage for sucking air is formed to be adsorbed to a wall surface by sucking air through the suction passage, and to be detached from the wall surface by releasing the suction,
an arm that has a front end part and a rear end part in the axial direction, and is supported by the supporting shaft through a first universal joint and supports an inflow pipe of the injection nozzle in the front end part through a second universal joint, and
a plurality of contact members that are attached to the rear end part of the arm, front ends of the plurality of contact members being adapted to contact the wall surface, and receiving a moment load generated in the arm when injecting the filler into the crack by means of the injection nozzle,
wherein the plurality of contact members are arranged in a direction orthogonal to the axial direction of the arm,
wherein the first universal joint comprises a spherical rotating member having a through hole through which the supporting shaft is inserted and a ring-like retention ring that rotatably retains the spherical rotating member,
a male screw is formed on an outer periphery of the supporting shaft,
a pressing coil spring is provided on the supporting shaft so that the pressing coil spring is loosely fitted to the supporting shaft in a compressed state between an upper surface of the adsorption disk and a lower surface of the arm, and
a regulation nut part that is screwed with the male screw on the supporting shaft on an upper surface side of the arm and regulates an upward movement of the arm is provided.

US Pat. No. 10,364,581

MASONRY CORNER JIG

1. A masonry corner jig comprising:a main elongate body including first and second portions extending from a midpoint, the main elongate body forming a plurality of apertures extending a length of the main elongate body at the midpoint;
first and second leg pegs each being sized and configured for selective attachment to the main elongate body on a respective one of the first and second portions;
first and second L-shaped plates each defining a central leg bracket including a first surface and a second surface; the central leg bracket being sized and configured for selective attachment to the main elongate body; the central leg bracket including a curved plate extending from the second surface, the curved plate forming a hole extending the length of the curved plate;
an adjustable grade stake sized and configured for engaged passage through the hole on each of the curved plates of the respective central leg brackets;
a metal plate defining a base, the base forming a body having a 90-degree cutout section wherein the point of the 90-degree cutout section is aligned with the center of the base; the base forming three holes along a perimeter zone of the base; a tube extending from the base and forming a channel sized for engaged receipt of the adjustable grade stake;
first and second legs each comprising:
a leg hinge having a first end and a second end that is sized and configured for attachment to the leg peg;
a leg rod having a first end and a second end that is sized and configured for attachment to the first end of the leg hinge;
an adjusting rod having a first end and a second end that is sized and configured for attachment to the first end of the leg rod; the adjusting rod having a hole through the center of the adjusting rod;
an adjusting pin that is sized and configured for engaged passage through the hole of the adjusting rod;
a cylinder defining an ankle rod, the ankle rod having a first end and a second end that is sized and configured for attachment to the first end of the adjusting rod; and
a foot plate that is sized and configured for attachment to the first end of the ankle rod.

US Pat. No. 10,364,580

GROUT INSTALLATION APPARATUS

1. A grout installation system including an apparatus having:a grout applying member, for applying grout to spaces between tiles comprised in a tiled area, the grout applying member comprising:
a grout tank having an internal space for storing grout, and
a grout dispensing head having an internal space in communication with the internal space of the grout tank for receiving grout therefrom; and
a grout removal member arranged rearward of the grout applying member, the grout removal member operable to remove grout from an outer surface of the tiles; wherein
the apparatus is operable to adopt a working position in which an outer edge of the grout dispensing head rests against the outer surface of the tiles, and in which the outer edge of the grout dispensing head defines a closed and planar perimeter encircling and delimiting an end opening of the grout dispensing head, the end opening in communication with the internal space of the grout dispensing head for receiving grout from the grout tank and dispensing said grout through the end opening to a portion of the tiled area delimited by the perimeter; wherein
the grout applying member further comprises a piston movable along the internal space of the grout tank and operable to force grout out of the internal space of the grout tank, into the internal space of the grout dispensing head, through the end opening of the grout dispensing head and into spaces between the tiles facing the end opening when said grout dispensing member is actuated.

US Pat. No. 10,364,579

VENTED AND WATER CONTROL CLADDING SYSTEM

Norwood Architecture, Inc...

1. A vented and water control system, consisting of:an exterior cladding panel configured to be mounted at a wall of a structure, the exterior cladding panel consisting of glass fiber reinforced plastic having a front surface, a back surface, and an omnidirectional relief pattern integral with the back surface and defined by a plurality of elements that form an omnidirectional ventilation and drainage plane between the wall and the back surface when the exterior cladding panel is mounted at the wall; and,
a non-structural finish layer located on the exterior cladding panel.

US Pat. No. 10,364,578

PANEL COATING

CERALOC INNOVATION AB, V...

1. A method for producing a laminated product, the method comprising:applying a powder-based sublayer comprising wood fibers and a thermosetting resin on a wood fiber based core;
applying a paper on the powder-based sublayer, wherein the paper is an unimpregnated paper when the paper is applied on the sublayer;
applying a protective overlay comprising a thermosetting resin and wear-resistant particles on the paper; and
applying heat and pressure in order to impregnate the paper, to cure the resins, and thereby obtain a laminated product.

US Pat. No. 10,364,575

ELEVATION-TYPE STAIR STRUCTURE

1. An elevation-type stair structure, comprising:a first stair module, including a plurality of first treads, a first platform, a second platform and a first wall surface, wherein said first wall surface includes a first door and a second door;
a second stair module, disposed at one side of said first stair module and including a plurality of second treads, a third platform, a fourth platform and a second wall surface, wherein said second wall surface includes a third door and a fourth door; and
an elevator module, fastened above said first stair module or said second stair module for enabling said first stair module or said second stair module to be ascended or descended, wherein when said second stair module is descended for being below a location defined at said one side of said first stair module, said first door is aligned with said fourth door; and when said second stair module is ascended for being above a location defined at said one side of said first stair module, said second door is aligned with said third door.

US Pat. No. 10,364,574

CONTINUOUS SCREW TIGHTENING MACHINE WITH WASHER STACKING SUPPLY MECHANISM

MURO CORPORATION, Tokyo ...

1. A continuous screw tightening machine with washer stacking supply mechanism comprising:a tightening machine body on which a driving machine is mounted and connecting a bit for screw tightening rotated/driven by the driving machine detachably and rotatably,
a tightening machine body guide mechanism advancing/retreating the tightening machine body between a standby position and an advanced position where the bit is advanced so as to be arranged at a position capable of tightening a screw,
a tip-end block provided below the tightening machine body guide mechanism and provided with a washer temporary accommodating portion for accommodating one washer having a hole through which the screw is inserted, capable of being withdrawn downward and a base plate capable of placing a large number of the washers in stacked arrangement, and arranged on a tightening target spot,
a screw-and-washer supply mechanism body arranged between the tightening machine body guide mechanism and the tip-end block and having an accommodating region for a large number of the washers in stacked arrangement on a rear side,
a washer sequential supply mechanism interlocked with the tightening machine body and incorporated in the accommodating region of the screw-and-washer supply mechanism body from a side portion to a lower part and for automatically supplying the washer on a lowermost stage in a large number of the washers stacked on the base plate and accommodated in the screw-and-washer supply mechanism body to the washer temporary accommodating portion in conjunction with retreating of the tightening machine body to the standby position by sliding it on the base plate of the tip-end block by a washer feeding body provided with a concave portion corresponding to an outer shape of the washer and automatically returning the washer feeding body in conjunction with advancing of the tightening machine body to an advanced position to a supply preparation position of the subsequent one washer,
a screw rope magazine accommodating a screw rope to which a large number of the screws are connected at a constant interval by a band-shaped member, capable of being fed out and detachably arranged on a rear part side of the screw-and-washer supply mechanism body, and
a screw sequential supply mechanism interlocked with the tightening machine body and incorporated in the screw-and-washer supply mechanism body and in conjunction with advancing of the tightening machine body to a position capable of tightening the bit, automatically moving a feeding claw for feeding each screw of the screw rope supplied from the screw rope magazine to a supply preparation position of the one screw connected to the screw rope and in conjunction with retreating of the tightening machine body to the standby position, automatically supplying the screw in order by the feeding claw so as to be in concentric arrangement between a tip end of the bit and a hole of the washer, wherein
rotation/driving of the bit advanced to the tightening possible position by the driving machine, removes the screw downward from the washer temporary accommodating portion such that the screw together with the washer is tightened and fixed teat the tightening target spot.

US Pat. No. 10,364,573

LAYOUT STARTER AND FIELD SHINGLE FOR SLOPED ASPHALT ROOFING

1. An asphalt shingle designed to be laid up in courses on a roof comprising:an upper headlap portion, a lower tab portion, vertically spaced apart upper and lower edges, laterally spaced apart right and left edges, and top and bottom surfaces, having a lateral dimension or width and a vertical dimension or height; and
a plurality of parallel, laterally-spaced vertical markings disposed across said top surface;
wherein the lateral dimension of the shingle is greater than the vertical dimension of the shingle,
wherein said bottom surface is configured to be laid up on a roof facing the roof,
wherein said tab portion is configured to be substantially weather-exposed when laid up on a roof and wherein said upper headlap portion is configured to be substantially covered by the tab portion of asphalt shingles in a next-overlying course of asphalt shingles when laid up on a roof; and
wherein, when the shingle is run up a rake of a roof with said upper and lower edges running parallel to the rake with either said upper or lower edge abutting said rake, said vertical markings are configured to act as headlap alignment marks and run perpendicularly to the rake of the roof, defining the positions on which courses of shingles should be abutted, and
wherein, when the shingle is run along an eave of a roof with said upper and lower edges running parallel to the eave, the plurality of parallel, laterally-spaced vertical markings are also configured to act as sidelap alignment marks and run perpendicularly to the eave of the roof, defining the positions on which subsequent courses of shingles should be abutted.

US Pat. No. 10,364,572

PREFABRICATED WALL PANEL FOR UTILITY INSTALLATION

Innovative Building Techn...

1. A utility panel, comprising:an exterior panel that includes:
a core;
a first board coupled to an exterior-facing surface of the core;
a second board coupled to an interior-facing surface of the core, wherein:
the core includes a foam plastic core that has the exterior-facing surface and the interior-facing surface,
the first board includes a magnesium oxide board coupled to the exterior-facing surface of the foam plastic core, and
the second board includes a fiber cement board coupled to the interior-facing surface of the foam plastic core;
a weather resistive barrier coupled to the first board, wherein the first board is positioned between the weather resistive barrier and the core; and
a plurality of cladding panels coupled to the weather resistive barrier, wherein the weather resistive barrier is positioned between the plurality of cladding panels and the first board;
a plurality of studs coupled to the exterior panel, wherein the plurality of studs include a plurality of punched studs;
a hat channel coupled to the plurality of studs substantially opposite the exterior panel, wherein the hat channel is substantially perpendicular to the plurality of studs; and
an interior panel coupled to the hat channel opposite the plurality of studs.

US Pat. No. 10,364,571

LIGHTWEIGHT STRUCTURAL PANEL

1. A structural panel configured for use in building installation comprising:a three-dimensional space frame assembly, wherein the space frame assembly comprises:
at least two longitudinal sides;
at least one lateral side;
a plurality of sinusoidal support members arranged in a lateral direction; and
a plurality of opposing reinforcing elements arranged in a longitudinal direction;
a pair of truss members, wherein one truss member in the pair is attached to each longitudinal side of the space frame assembly;
a pair of stud members, wherein one stud member is attached to each longitudinal side of the space frame assembly and a corresponding said truss member as a bracing system, each stud member comprises a plurality of apertures located along a longitudinal length thereof;
a foam layer which is provided throughout the space frame assembly, truss members, and stud members;
a plurality of first cavities, wherein each first cavity lines up with a corresponding said aperture and extends in the lateral direction from the one stud member to the other stud member; and
a plurality of second cavities, wherein each second cavity extends in the longitudinal direction through a body of the panel;
wherein the structural panel possesses load bearing capacity and the truss members, sinusoidal support members, stud members, and reinforcing elements provide structural integrity and load bearing capacity independent of the foam layer.

US Pat. No. 10,364,570

BUILDING FORMS AND METHOD OF ASSEMBLING SAME

EZ PVC LLC, Las Vegas, N...

1. A building wall system including a plurality of forms for filling with concrete and constructing a building wall comprising:a corner form assembly including an inner corner form and an outer corner form for assembling from an unassembled condition to an assembled condition;
said outer corner form including a pair of outer walls angled to one another from a vertex to define a first angle extending between said outer walls;
each of said outer walls extending from said vertex to a respective outer form connector;
said outer corner form includes a corner web extending between said outer walls and disposed in spaced relationship with said outer form connectors;
said inner corner form including an inner wall extending from a first end to a second end and having a first pair of connectors disposed at said first end and a second pair of connectors disposed at said second end; and
said first pair of connectors disposed on opposite sides of said inner wall and at least one of said first pair of connectors interconnected with one of said outer form connectors to establish said assembled condition for assembling said corner form assembly around a preset rebar in a corner footing.

US Pat. No. 10,364,568

FABRICATED BUILDING

1. A fabricated building comprising:a wall structure defining an interior side and an exterior side;
a roof frame supported on the wall structure;
a roof skirt supported by the wall structure and including a skirt tongue with a leading edge located on the exterior side of the wall structure;
a roll up roof supported by the roof frame and including a roof tongue with a leading edge located on the exterior side of the wall structure; and
a roof lock that retains the roll up roof on the wall structure that is formed from the leading edge of the skirt tongue folded with the leading edge of the roof tongue.

US Pat. No. 10,364,567

CONNECTOR FOR FRAMING MATERIAL

1. A connector for framing material comprising:a limiting member having a plate member, the plate member provided with a through aperture, a first stopping plate provided at a side of the plate member and a second stopping plate provided at another side of the plate member, the plate member, the first stopping plate and the second stopping plate forming a containing space, each end of the first stopping plate and the second stopping plate respectively having an engaging portion and a pressing portion, the engaging portion of the first stopping plate facing the pressing portion of the second stopping plate, the pressing portion of the first stopping plate facing the engaging portion of the second stopping plate, the first stopping plate and the second stopping plate respectively further provided with two engaging slots facing the plate member and disposed among the engaging portion and the pressing portion;
a connecting member having a through hole; and
a first screw having a hexagon portion at an end, the first screw placed through the through aperture of the limiting member and the through hole of the connecting member, an end of the first screw passing through the through hole of the connecting member and screwed with a nut, the hexagon portion of the first screw limited between the first stopping plate and the second stopping plate, the containing space allowing the hexagon portion and the limiting member to rotate synchronously;
wherein the connecting member has a bottom plate and two opposing sidewalls, the two sidewalls perpendicularly connected with the bottom plate, the through hole disposed in the bottom plate, and both of the sidewalls are respectively provided with an elongate slot correspondingly engaged with a second screw and second nut.

US Pat. No. 10,364,565

SUB-FLOOR BRACE FOR ABATING SQUEAKING FLOORS

1. A structural element comprising:a first support, a second support, and a fastener;
wherein the fastener attaches the first support to the second support;
wherein the structural element is configured for use with a supported flooring;
wherein the supported flooring is further defined with joists and a flooring;
wherein the supported flooring is further defined with a floor side and a ceiling side;
wherein the structural element is configured to support the supported flooring from the ceiling side of the supported flooring;
wherein the supported flooring refers to a horizontal surface upon which the structural element is placed in use;
wherein in use the horizontal surface receives the load from the supported flooring that is being distributed through the structural element;
wherein the structural element is a telescopic structure;
wherein the first support comprises a first stanchion and a first cantilever;
wherein the first cantilever attaches to the first stanchion;
wherein the first stanchion is further defined with a first end, a second end, and a first center axis;
wherein the first cantilever is further defined with a third end, a fourth end, a second center axis, and an inner dimension;
wherein the first stanchion is a hollow square metal perforated tube;
wherein the first cantilever is a hollow square metal perforated tube;
wherein the first cantilever is formed from the same tube stock as the first stanchion;
wherein the second support comprises a second stanchion and a second cantilever;
wherein the second cantilever attaches to the first cantilever;
wherein the second stanchion is further defined with a fifth end, a sixth end, and a third center axis;
wherein the second cantilever is further defined with a seventh end, an eighth end, a fourth center axis, and an outer dimension;
wherein the second stanchion is a hollow square metal perforated tube;
wherein the dimensions of the second stanchion are identical to the dimensions of the first stanchion;
wherein the second cantilever is a hollow square metal perforated tube;
wherein the tube stock of the second cantilever is selected such that the outer dimension of the second cantilever is lesser than the inner dimension of the first cantilever such that the second cantilever can be inserted into the first cantilever;
wherein the fastener is a mechanical detent;
wherein the third end of the first cantilever attaches to the second end of the first stanchion such that the second center axis intersects perpendicularly with the first center axis;
wherein the third end of the first cantilever attaches to the second end of the first stanchion such that the face of the first cantilever is flush with the second end of the first stanchion;
wherein the seventh end of the second cantilever attaches to the sixth end of the second stanchion such that the fourth center axis intersects perpendicularly with the third center axis;
wherein the seventh end of the second cantilever attaches to the sixth end of the second stanchion such that the span of the distance between the fourth center axis and the fifth end of the second stanchion is sized such that the fourth center axis and the second center axis are aligned when the first end of the first stanchion and the fifth end of the second stanchion are placed upon the supporting flooring;
wherein this alignment will allow the eighth end of the second cantilever to be inserted into the fourth end of the first cantilever when the structural element is in use.

US Pat. No. 10,364,564

SUPER DRAINAGE SYSTEM AND METHOD FOR FLOOD CONTROL

1. A drainage system configured for controlling flood during extreme weather and comprising a road for traffic during normal weather, said system comprising:a) an open channel having a first bank, a second bank and a riverbed;
b) a reinforced concrete conduit (RCC), said RCC has a bottom slab supported on said riverbed, a first wall for retaining said first bank, a top slab elevated above a predetermined level and a second wall and said RCC further comprising a number of RCC segments, each of said RCC segments having a male end and a number of RCC segments, each of said RCC segments having a male end and a female end;
c) an opening in said RCC for water communication with said open channel; and
wherein said RCC supports said road below the top of said first bank, and said traffic travels on said road along said first bank during normal weather.

US Pat. No. 10,364,563

RUNOFF WATER MANAGEMENT SYSTEM

1. A drywell apparatus for collecting and diverting runoff surface water or waste water, and controlling the flow and direction of subsurface water, comprising:a top having a large diameter, central, top port, opening into a drywell apparatus interior, said top port adapted to receive surface water;
an open bottom;
a cylindrical sidewall interconnecting the drywell top and bottom, said drywell top, bottom and sidewall defining the drywell apparatus interior, said sidewall having an exterior surface and an interior surface, said sidewall having a plurality of rectangular drain-type ports distributed about the sidewall;
a plurality of interior diverters attached to the sidewall interior, within the drywell interior, each interior diverter positioned about one of the plurality of drain-type ports, each interior diverter having a front, rear, open top, bottom, and two opposite, identical sides, said interior diverter front, rear, top, bottom and sides defining a hollow interior diverter interior, wherein the interior diverter rear is divided into two sections, a top section and a lower section, wherein said interior diverter rear top section is flat and extends vertically downward to a horizontal line, wherein the interior diverter rear lower section extends downward from the horizontal line and forward to a beginning of the interior diverter bottom, wherein a plurality of downwardly extending flanges are formed at a junction of the interior diverter rear lower section and the interior diverter bottom, wherein the interior diverter front has a plurality of holding tabs adjacent the interior diverter top and extending from the interior diverter sides toward each other, wherein the remainder of the interior diverter front is open;
wherein the interior diverter front engages one of the plurality of drain-type ports and the interior diverter bottom is seated on a drain-type port horizontal bottom, wherein the interior diverter downwardly extending flanges engage the side wall interior beneath one of the plurality of drain-type ports, wherein the interior diverter holding tabs are attached to the side wall interior above a one of the plurality of drain-type ports;
wherein water from the drywell apparatus interior enters the interior diverter top through the diverter interior, out through the diverter front, through one of the plurality of drywell drain-type ports, laterally dispersing into the surrounding soil, beginning at the top of a drywell, said interior diverter rear and sides preventing backfill soil from intruding into a drywell interior.

US Pat. No. 10,364,562

SANITARY WASHING DEVICE

TOTO LTD., Kitakyushi-Sh...

1. A sanitary washing device comprising:a heating part;
a first temperature sensor configured to sense temperature of water heated by the heating part;
a second temperature sensor provided downstream of the first temperature sensor and configured to sense temperature of the water;
a nozzle provided downstream of the second temperature sensor and configured to jet the water toward human private parts; and
a controlling part configured to determine that the second temperature sensor is abnormal when change of the temperature sensed by the first temperature sensor is larger than a predetermined first value and change of the temperature sensed by the second temperature sensor is smaller than a predetermined second value.

US Pat. No. 10,364,561

DRAIN VALVE FOR A FLUSHING CISTERN AND FLUSHING CISTERN HAVING A DRAIN VALVE

1. A drain valve for a sanitary flushing cistern, in particular a flush-mounted flushing cistern, comprising a valve housing and a valve body guided in the valve housing and configured as an overflow pipe having a seal assigned to a valve seat, wherein the valve body is provided with at least one pull tab for lifting the valve body, and one buoyant body, wherein the valve housing at its upper end is provided with a spacer for aligning and fixing the drain valve in the flushing cistern, wherein the pull tab is pivotably connected to the valve body and the spacer has an abutment assigned to the pull tab, which functions as a pivot point for the pull tab, so that the pull tab is movable from an upright position into a folded position and the valve body connected to the pull tab in the folded position of the pull tab is raised vis-à-vis the valve seat.

US Pat. No. 10,364,560

TRAP WATER REMOVAL APPARATUS AND METHOD OF USE

Platypus Tools Inc., (CA...

1. A method for removing water from a trap of a drain of a plumbing device, comprising the steps of:a) providing an apparatus for removing water from said trap,
said apparatus comprising:
a housing comprising side walls defining an elongated reservoir, a first opening and a second opening;
a plunger assembly having a plunger member sealingly engaged with sidewalls of the elongate reservoir and movable within the elongate reservoir; and
a pliable and/or flexible hose coupled to the second opening of the housing in fluid communication with the reservoir, and including an open end;
b) positioning the hose open end into the trap of the plumbing device;
c) actuating said plunger assembly to draw water from said trap;
d) temporarily retaining said water within said reservoir prior to disposal of said water in a further portion of the drain downstream of the trap;
e) repositioning the hose open end for fluid communication with the further portion of the drain downstream of the drain trap; and
f) actuating said plunger assembly to expel said water from said reservoir through the hose open end downstream of the trap and out of the plumbing device.

US Pat. No. 10,364,559

PLUMBING DEVICE

1. A connector comprisingan inlet connector,
a chamber having an open upper chamber and a lower closable chamber, and
an outlet connector formed in a floor of the lower chamber
wherein the inlet connector is supported above the open upper chamber by a plurality of horizontally spaced arms such that a vertical gap is formed between an inlet and the upper chamber, the arms being arranged so that the horizontal spacing between the arms and the vertical gap are sufficient to provide an air break to drain, and wherein the lower chamber is closable by a non-return valve which is arranged to open at a pre-selected pressure.

US Pat. No. 10,364,558

BOTTLE TRAP

1. A bottle trap for washbasin sink, the bottle trap comprising:a main body having an open end and a tapered closed end, the open end adapted to be coupled to a tailpiece pipe from a sink and the tapered closed end has at least one face inclined at a first angle with respect to a longitudinal axis of the main body;
a cylindrical trap element received through the open end and extending axially into the main body up to at least half the length of the main body, the cylindrical trap element dividing the main body into an inner cylindrical portion and an outer cylindrical portion, the inner cylindrical portion and the outer cylindrical portion being fluidically coupled;
an outlet orifice provided on peripheral surface of the main body perpendicularly thereto, the outlet orifice is fluidically coupled to the outer cylindrical portion and is adapted to be coupled to a horizontal drain pipe;
a thread-less coupling provided at the open end and the outlet orifice, for connecting the tailpiece pipe and the drain pipe, respectively, thereto for ensuring a leakproof coupling, said thread-less coupling being based on a connecting seal having a cylindrical body with a circumferential groove on its outer cylindrical surface, and a complementary inward projecting first annular projection on the open end and the outlet orifice, the first annular projection being adapted to engage with the circumferential groove on the respective connecting seal; and
at least one sealable drain orifice provided at the at least one inclined face of the tapered closed end, the drain orifice being fluidically connected to the outer cylindrical portion for enabling draining out of blockage particles therein by opening the drain orifice,wherein the main body is a monolithic block and joint free, andwherein the at least one sealable drain orifice is adapted to be sealed by a removable closure, andwherein during operation liquid from the tailpiece pipe enters into the inner cylinder portion towards the outer cylinder portion for being directed out of the outlet orifice into the drain pipe.

US Pat. No. 10,364,557

FAUCETS PROVIDING MIXED WATER AND AIR FLOW

GLOBE UNION INDUSTRIAL CO...

1. A faucet comprising:a faucet base having a first and second end, the faucet base being adapted to be mounted to support the faucet near the first end and to regulate a water flow through the faucet;
a water hose coupled with the faucet base by extending through the first end and second end of the faucet base, the water hose being adapted to be flexible and movable through an opening in the first end and through an opening in the second end;
a faucet head movably coupled to the second end of the faucet base, the faucet head being adapted to be dismountable from the second end of the faucet base while remaining coupled to the water hose to direct a mixture of water-and-air flow to a location away from the faucet base and to be relocated back to the second end the faucet base to discharge the mixture of water-and-air flow while being coupled to the faucet base;
a chamber within the faucet head having a first end and a second end, the first end of the chamber being coupled with the water hose and being coupled, in a dismountable manner, to the second end of the faucet base, the second end of the chamber providing an outlet to discharge the mixture of water-and-air flow;
a water valve within the chamber and located between the first end and the second end of the chamber, the water valve comprising:
at least one air inlet and a water inlet to enable mixing air from the at least one air inlet with water from the water inlet, the water inlet being coupled with the water hose, the at least one air inlet being coupled with the chamber, and
a control valve movable within the water valve between a first position and a second position, the first position enabling mixing air from the at least one air inlet with water from the water inlet to provide the mixture of water-and-air flow, and the second position enabling shut-off of the mixture of water-and-air flow, a direction of the control valve's movement between the first position and the second position being substantially parallel to a direction of the water flow from the first end of the chamber to the second end of the chamber, the control valve using a water pressure supplied by the water hose to facilitate an operation of the control valve; and
a control member movably coupled with the faucet head, the control member being adapted to enable an operation of the control valve within the water valve by pressing the control member from a side of the faucet head to move the control valve between the first position and the second position, wherein
the chamber includes a cavity between the first end and the second end of the chamber for receiving the water valve, and the water valve is a pre-assembled assembly with the control valve inside the water valve and with a driving member protruding through one end of the water valve and coupled with the control valve to cause the control valve to move between the first and the second position.

US Pat. No. 10,364,556

TENSION-BASED MECHANICAL COUPLING DEVICE

Hunter Innovations, LLC, ...

1. A mechanical-coupling device comprising:a bolt having a bolt body and a bolt head attached to the bolt body, wherein at least a portion of the bolt body has threads and the bolt head includes a fixture configured to remateably mechanically couple to an attachment tool;
an anchor nut configured to rotatably mechanically couple to the bolt using the threads on the bolt body, wherein rotation of the anchor nut is about a symmetry axis of the bolt body; and
an anchor wing rotatably mechanically coupled to the anchor nut, wherein rotation of the anchor wing, between a deployed position and a retracted position, is about an axis approximately perpendicular to the symmetry axis of the bolt body,
wherein, in the absence of an external force, the anchor wings remain in the deployed position, extending substantially perpendicular to the symmetry axis of the bolt and radially outward from the bolt,
wherein, during mechanical coupling of the anchor nut to the bolt with a mounting material between the bolt head and the anchor nut, the fixture is configured to convey:
a pulling force, from the attachment tool, that results in fixing a position of the anchor nut with the anchor wing in the deployed position, and
a rotational torque, from the attachment tool, about the symmetry axis of the bolt body that rotates the bolt relative to the fixed position of the anchor nut so that a distance between the bolt head and the anchor nut decreases, and
wherein the bolt body comprises an axial bore therethrough defining an internal passage having an inner surface, the axial bore aligned with the symmetry axis of the bolt body.

US Pat. No. 10,364,555

THERMAL MONITOR CLAMP AND METHOD FOR DETECTING THE TEMPERATURE OF A FLUID WITHIN A CONDUIT

Sentinel Hydrosolutions, ...

1. A noninvasive thermal monitor clamp for detecting the temperature of a fluid within a thermally-conductive fluid conduit to determine the fluid flow rate of the fluid, comprising:a heat sink;
a spring clip disposed to removably mount the heat sink to an outer surface of the fluid conduit, wherein the spring clip and the heat sink circumscribe the fluid conduit;
an electric temperature sensor attached to the heat sink, in thermal communication with the outer surface of the fluid conduit and capable of sensing heat energy of the fluid within the fluid conduit;
a heating element attached to the heat sink and thermally coupled to the temperature sensor, wherein the temperature sensor is capable of sensing heat energy of the heating element; and
monitoring the temperature when the heating element is active to determine the amount of time for the heat energy added by the heating element to propagate to the electric temperature sensor, wherein a propagation time of the heat energy from the heating element to the electric temperature sensor is a direct function of the fluid flow rate of the fluid.

US Pat. No. 10,364,554

WEAR ASSEMBLY

ESCO GROUP LLC, Portland...

1. A wear member for attachment to earth working equipment to protect the equipment from wear during use, the wear member comprising a wear surface to contact the ground during operation of the earth working equipment, a mounting structure to effect mounting of the wear member on the earth working equipment, a hole defined by a wall extending through the wear member and opening in both the wear surface and the mounting structure to receive a lock to hold the wear member to the earth working equipment, the wall defining the hole including a retaining structure between the wear surface and the mounting structure, and the retaining structure having an upper shoulder and a lower shoulder for contacting corresponding bearing surfaces on the lock to positively hold the lock in the hole against inward and outward forces on the lock wherein the wall defining the hole defines a passage adjacent the retaining structure and extending along the length of the hole from the mounting structure toward the wear surface to permit a lock component of a unified construction to be installed in the hole and contact the upper shoulder and the lower shoulder.

US Pat. No. 10,364,552

EXCAVATOR LINKAGE ANGLE DETERMINATION USING A LASER DISTANCE METER

Caterpillar Trimble Contr...

1. An excavator calibration framework comprising an excavator, a laser distance meter (LDM), and a laser reflector, wherein:the excavator comprises a machine chassis, an excavating linkage assembly, an excavating implement, and control architecture;
the excavating linkage assembly comprises an excavator boom, and an excavator stick, and a four-bar linkage that collectively define a plurality of linkage assembly positions;
the excavator stick is mechanically coupled to a terminal pivot point B of the excavator boom;
the four-bar linkage comprises a node D, a node F, a node G, and a node H, and linkages disposed therebetween, the linkage between the nodes D and F defining a dogbone linkage;
the LDM is configured to generate one or more measurement signals indicative of a distance and an angle between the LDM and the laser reflector;
an outer triangle BGF is defined between the node F, the terminal pivot point B, and the node G;
the outer triangle BGF comprises a first length BG, a second length BFi, a third length GFi;
the node D is positioned within the outer triangle BGF and defines, with the outer triangle BGF, three inner triangles DGB, DBF, and DFG within the outer triangle BGF;
the control architecture comprises one or more linkage assembly actuators and an architecture controller programmed to execute an iterative process, the iterative process comprising:
disposing the laser reflector at a position corresponding to the node F;
generating a measurement signal indicative of a distance and an angle between the LDM and the laser reflector;
determining a position of the node F based on the generated measurement signal;
determining the second length BFi and the third length GFi of the outer triangle BGF at least partially based on the position of the node F;
determining an angle BGD (?BGD) of the inner triangle DGB at least partially based on the second length BFi, and the third length GFi of the outer triangle BGF;
determining a position of the node D at least partially based on the angle BGD (?BGD);
determining a length BD along the excavator stick between the terminal pivot point B and the node D at least partially based on the position of the node D; and
determining a dogbone angle BDF (?BDF) of the inner triangle DBF based on the length BD along the excavator stick, a dogbone length DF of the dogbone linkage of the four-bar linkage, and the second length BFi of the outer triangle BGF, the dogbone angle BDF (?BDF) corresponding to an angular orientation of the dogbone linkage with respect to the length BD along the excavator stick; and
the architecture controller is further programmed to:
repeat the iterative process i times until i passes an iterative threshold;
generate an actual dogbone angle BDF (?BDFactual) based on a series of dogbone angles BDF determined from the iterative process; and
operate the excavator using the actual dogbone angle (?BDFactual).

US Pat. No. 10,364,551

WORK MACHINE

KUBOTA CORPORATION, Osak...

1. A work machine comprising:a prime mover;
a hydraulic pump configured to be operated by the prime mover and outputting an operation fluid;
a hydraulic device configured to operate via the operation fluid;
a measurement sensor configured to measure a first temperature and a second temperature, the first temperature being a temperature of the operation fluid at starting of the prime mover, the second temperature being a temperature of the operation fluid after the starting of the prime mover; and
a controller configured to:
utilize a predetermined starting upper limitation revolution speed as an upper limit revolution speed at the starting of the prime mover, the upper limit revolution speed being an upper limit of a revolution speed of the prime mover;
change, after the starting of the prime mover, the upper limit revolution speed to a changed upper limitation revolution speed obtained by adding a correction value to the starting upper limitation revolution speed, the correction value being obtained by multiplying a temperature difference between the first temperature and the second temperature by a predetermined correction revolution speed; and
the controller including a revolution controller configured to control the revolution speed of the prime mover based on the starting upper limitation revolution speed at the starting of the prime mover and to control the revolution speed of the prime mover based on the changed upper limitation revolution speed after the starting of the prime mover.

US Pat. No. 10,364,550

HYDRAULIC DRIVE SYSTEM OF WORK MACHINE

Hitachi Construction Mach...

1. A hydraulic drive system of a work machine comprising:an engine;
first and second hydraulic pumps driven by the engine;
first and second pump hydraulic lines to which a delivered hydraulic fluid from the respective first and second hydraulic pumps is supplied;
at least one first actuator driven by the hydraulic fluid supplied from the first pump hydraulic line;
a plurality of second actuators driven by the hydraulic fluid supplied from the second pump hydraulic line;
a first directional control valve provided in the first pump hydraulic line and controlling a flow rate of the hydraulic fluid supplied to the first actuator;
a plurality of second directional control valves provided in the second pump hydraulic line and each controlling the flow rate of the hydraulic fluid supplied to the plurality of second actuators;
a plurality of operation devices operating the first actuator and the plurality of second actuators by respectively switch-operating the first directional control valve and the plurality of second directional control valves;
an electric motor;
a third hydraulic pump driven by the electric motor;
a third pump hydraulic line to which a delivered hydraulic fluid from the third hydraulic pump is supplied;
a third directional control valve provided in the third pump hydraulic line, switch-operated by a specific operation device of the plurality of operation devices that operates a specific actuator of the plurality of second actuators, and controlling the flow rate of the hydraulic fluid supplied to the specific actuator from the third hydraulic pump;
a plurality of operation amount detection sensors detecting operation amounts of the plurality of operation devices; and
a control device that is configured to control the electric motor in accordance with operation amounts of the plurality of operation devices corresponding to the plurality of second actuators out of the operation amounts detected by the plurality of operation amount detection sensors,
wherein the control device is further configured to control the third directional control valve such that the third hydraulic pump supplies the hydraulic fluid to the specific actuator, with a hydraulic line that supplies the hydraulic fluid from the second hydraulic pump to the specific actuator being restricted, when a combined operation of two or more second actuators including the specific actuator out of the plurality of second actuators is detected by the plurality of operation amount detection sensors.

US Pat. No. 10,364,549

HYBRID CONSTRUCTION MACHINE

Hitachi Construction Mach...

1. A hybrid construction machine comprising:a vehicle body that is provided with a revolving structure;
a working mechanism that is provided on said revolving structure;
an engine that is provided on said vehicle body;
a motor-generator that is connected mechanically to said engine;
an electricity storage device that is connected electrically to said motor-generator;
a hydraulic pump that is connected mechanically to said engine;
a plurality of actuators that drive said vehicle body or said working mechanism, and include a boom cylinder and a revolving hydraulic motor that are driven by pressurized oil from said hydraulic pump;
a revolving electric motor that is provided on said vehicle body and connected electrically to said motor-generator and said electricity storage device to revolve said revolving structure by compound torque with said revolving hydraulic motor;
an actuator operation device that drives said plurality of actuators in accordance with an operating amount; and
a controller that controls output of said motor-generator and has a low speed mode for reducing movement speeds of said plurality of actuators in response to conditions of said motor-generator and said electricity storage device and a normal mode in which a reduction in the movement speeds of said plurality of actuators is released characterized in that:
said controller is configured to reduce output of said boom cylinder and said revolving hydraulic motor in such a manner as to hold a ratio of output of revolving movement and output of boom-raising movement to the same value of a ratio in said normal mode at the time of performing a compound movement that includes said revolving movement and said boom-raising movement of said working mechanism in said low speed mode, and is configured to control output of said revolving electric motor, and
said controller increases a reduced value of the output of said motor-generator to be larger than a reduced value of the output of said revolving electric motor when said compound movement is performed in said low speed mode and said revolving electric motor and said motor-generator simultaneously perform powering operations.

US Pat. No. 10,364,548

METHOD OF OPTIMIZING PERFORMANCE OF MACHINES AT A WORKSITE

Caterpillar Inc., Deerfi...

1. A method of operations of machines at a worksite, the method comprising:receiving, by a control system, pre-construction terrain data associated with the worksite;
receiving, by the control system, design terrain data associated with the worksite;
receiving, by the control system, resource data associated with the machines;
defining a plurality of constraints associated with the operations based on the pre-construction terrain data, the design terrain data, and the resource data;
simulating the operations of the machines at the worksite based on the pre-construction terrain data, the design terrain data, and the resource data;
estimating process variables associated with the operations based on the simulation of the operations and the plurality of constraints;
providing an optimized operational level task to an operator of a machine based on the estimated process variables;
collecting real time data associated with the operations performed at the worksite using a communication medium;
updating the estimated process variables associated with the operations of the machines based on the collected real time data; and
providing a performance indicator to the operator based on the optimized task and the real time data.

US Pat. No. 10,364,547

HYBRID WORK MACHINE

Hitachi Construction Mach...

1. A hybrid work machine comprising an engine, a generator motor driven by the engine, an electrical storage device that supplies and receives electric power to and from the generator motor, a hydraulic pump driven by the engine and the generator motor, hydraulic actuators driven by a hydraulic oil delivered from the hydraulic pump, operating members used to operate the hydraulic actuators, and a controller that controls the hydraulic actuators in accordance with operating amounts of the operating members,wherein, when a plurality of specific operations defined as predetermined ones among a plurality of work operations performed by the hybrid work machine are performed under condition of a degree of tendency to deterioration of the electrical storage device becoming higher, the controller determines in accordance with the operating amounts of the operating members whether the specific operations are performed, and reduces, in accordance with a determination result, speeds of the hydraulic actuators corresponding to the specific operations at rates preset for the specific operations depending on the degree of tendency to deterioration of the electrical storage device, the rates being the same.

US Pat. No. 10,364,546

CONTROL SYSTEM FOR WORK VEHICLE, CONTROL METHOD, AND WORK VEHICLE

KOMATSU LTD., Tokyo (JP)...

1. A control system for a work vehicle including a work implement, the control system comprising:an operating device configured to receive operations from an operator for driving the work implement and to output an operation signal in accordance with an operation amount of the operating device; and
a controller programmed to control the work implement based on the operation signal, the controller including
a storage unit for storing construction information defining a design terrain which represents a target shape of a work object;
a distance obtaining unit for obtaining a distance between the work implement and the design terrain;
a work aspect determining unit for determining whether or not a work aspect by the work implement is a surface compaction work based on the operation signal; and
a limit velocity deciding unit that executes a normal velocity limit control for limiting a velocity of the work implement to a limit velocity when the distance is equal to or smaller than a first distance and the work aspect is not the surface compaction work,
the limit velocity deciding unit executing a surface compaction control instead of the normal velocity limit control when the work aspect is the surface compaction work and the distance is within a first range, a largest distance of the first range being the first distance, the surface compaction control being executed such that the limit velocity of the work implement is larger than during the normal velocity control within the first range.

US Pat. No. 10,364,545

BRACKET ASSEMBLY FOR LINKAGE ASSEMBLIES OF MACHINES

Caterpillar Inc., Deerfi...

1. A bracket assembly for coupling an implement to an arm of a machine, the bracket assembly comprising:a bracket including a plate with an opening having an inner wall, the inner wall including a plurality of engagement structures arranged along an axial direction of the opening, and being longitudinally spaced apart from each other; and
a bushing adapted to be inserted into and positioned within the opening, the bushing including a cylindrical portion with an outer surface, an end, and a plurality of mating structures arranged on the outer surface and longitudinally spaced apart from each other along an axial direction of the cylindrical portion,
wherein an engagement between the plurality of engagement structures and the plurality of mating structures facilitates multiple positions of the end relative to the plate, and
wherein each engagement structure of the plurality of engagement structures includes a J-shaped protrusion defining a cavity to receive one mating structure of the plurality of mating structures.

US Pat. No. 10,364,543

METHOD AND APPARATUS FOR PORTABLE STAKE MOUNTING

1. A stake assembly for providing an earth anchor, comprising:a concave portion arranged facing the earth, wherein the concave portion has a top wall and a depending sidewall below the top wall, the sidewall enclosing a perimeter and having an open bottom end;
a stake portion engaged to the concave portion comprising a shaft having a diameter, the shaft intended to be driven into the earth, wherein the stake portion has a stop carried on an upper part of the shaft, and the top wall has a hole, wherein the hole is sized having a hole diameter greater than the diameter to allow the shaft to pass through the hole from above but not sized to allow the stop to pass through the hole; and
the concave portion is arranged to capture earth therein when the concave portion is driven into the earth, the hole allowing the concave portion to be driven into the earth first and the stake portion be subsequently driven through the hole and into the earth;
wherein the concave portion includes a socket open into the hole and the stake portion includes a plug, wherein the plug fits into the socket when the stake is fully inserted into the concave portion.

US Pat. No. 10,364,542

OPEN END FRICTION PILE

BLACK BEAR INNOVATION, LL...

1. A friction pile, comprising:a plurality of pile plates each having a first distal end, a second distal end, and a center portion between the first and second distal ends, the first distal end of each of the pile plates connected to the second distal end of another pile plate such that the plurality of pile plates defines a three-dimensional structure having an open bottom end;
a plurality of brackets each connected to one of the plurality of pile plates; and
a driving head comprising:
a base plate connected to the plurality of brackets and covering a top end of the three-dimensional structure;
at least one end plate extending from the base plate in a direction opposite the plurality of pile plates; and
a webbing portion extending from the at least one end plate.

US Pat. No. 10,364,541

TEMPORARILY COUPLING BETWEEN JACKET AND PILE AND METHOD OF COUPLING

IHC Holland IE B.V., Sli...

1. A method for coupling a jacket with a foundation pile, comprising;mounting a first flange with the jacket,
contacting a second flange with the foundation pile such that the second flange is supported by the foundation pile,
mutually positioning the first flange and the second flange such that the jacket is supported by the pile through the first flange and the second flange,
arranging an inflatable spacing member between the first flange and second flange such that the spacing member contacts both the first flange and second flange for supporting the jacket through the spacing member;
inflating the spacing member for increasing a spacing between the first flange and second flange; and
detaching the spacing member from at least one of the first flange and second flange.

US Pat. No. 10,364,540

SYSTEM FOR INDUCTIVE POWER TRANSFER, PAVEMENT SLAB ASSEMBLY AND METHOD OF OPERATING A SYSTEM FOR INDUCTIVE POWER TRANSFER

Bombardier Primove GmbH, ...

1. A system for inductive power transfer to vehicles driving or standing on a surface of a route, comprising:a primary winding structure for generating an alternating electromagnetic field, wherein a field volume is assigned to the primary winding structure; and
at least a part of a first heating system, wherein elements of the first heating system which are arranged within the field volume are non-metallic elements,
wherein the system comprises at least a part of at least one other heating system, wherein all elements of the at least one other heating system are arranged outside the field volume.

US Pat. No. 10,364,538

APPARATUS FOR ABSORBING ENERGY RESULTING FROM VEHICLE IMPACT

Lindsay Transportation So...

1. Apparatus positioned at a guardrail lead end portion for absorbing energy resulting from vehicle impact, said guardrail having an elongated top edge, an elongated bottom edge spaced a predetermined substantially uniform vertical distance from said top edge and opposed side surfaces extending between said elongated top edge and said elongated bottom edge, said apparatus comprising:an impact terminal;
a support structure supporting said impact terminal at or adjacent to the guardrail lead end portion, said support structure extending from said impact terminal;
a guardrail engagement structure supported by said support structure, said guardrail engagement structure defining an interior, a guardrail receiving opening communicating with said interior receiving the guardrail lead end portion, and a guardrail discharge opening communicating with said interior, said support structure and said guardrail engagement structure operable upon vehicle impact on said impact terminal to move along said guardrail and cause said guardrail to pass through said guardrail engagement structure and exit said guardrail discharge opening, the guardrail engagement structure comprising a chute having inner chute surfaces defining said interior, said inner chute surfaces having a generally rectangular configuration along substantially the full length thereof whereby said interior has a generally rectangular cross sectional configuration along substantially the full length thereof, said chute twisted between said guardrail receiving opening and said guardrail discharge opening, said guardrail being in frictional engagement with said inner chute surfaces, and said chute applying torquing forces on said guardrail during passage of said guardrail through said guardrail engagement structure to cause twisting of said guardrail from a first guardrail orientation whereby said guardrail exits said guardrail discharge opening in a second guardrail orientation with said elongated top edge and said elongated bottom edge displaced sideways relative to one another and vehicle collision impact energy is absorbed.

US Pat. No. 10,364,537

CONSTRUCTING APPARATUS AND METHOD OF GUIDE LINE FOR ROAD

KOREA EXPRESSWAY CORP., ...

1. An apparatus for constructing a guide line for a road, the apparatus comprising:a painting apparatus part that stores a lane paint, is driven by receiving power, and supplies the lane paint;
a nozzle part that is installed in the painting apparatus part and sprays the lane paint supplied from the painting apparatus part to form a guide line for a road including at least one of a directional mark and a lane;
the nozzle part comprising
a first nozzle member that is installed at one side of the painting apparatus part and receives and sprays a first lane paint from the painting apparatus part to form the lane, and
a second nozzle member that is installed at the other side of the painting apparatus part and receives a second lane paint from the painting apparatus part and sprays the second lane paint on the lane to form the directional mark and form the guide line for the road; and
an adjustment part that is installed in the painting apparatus part and adjusts at least one of a location and an interval of the lane paint sprayed from the nozzle part;
the adjustment part presetting an interval and a time at which the second lane paint is sprayed from the second nozzle member so that the directional mark is formed at a predetermined interval.

US Pat. No. 10,364,536

COLLAPSIBLE ROTOR DRIVETRAIN

Caterpillar Paving Produc...

9. A cold planer, comprising:a frame;
a drive shaft mounted to the frame; and
a rotor system removably attached to the frame, the rotor system comprising:
a milling drum configured to rotate within a rotor chamber;
a drive train coupling the drive shaft and the milling drum; and
a connecting member configured to adjust the drive train,
wherein the connecting member is configured to adjust a width of the drive train from an operation position having a first width to a transport position having a second width less than the first width.

US Pat. No. 10,364,534

PAVEMENT REPAIR SYSTEM

1. A method for providing an elastomer coating, comprising:applying an elastomer composition to a substrate; and
irradiating the elastomer composition with radiation having a preselected peak wavelength of from 1 nm to 5 mm, whereby the elastomer composition is cured to yield a protective and self-healing elastomer coating.

US Pat. No. 10,364,532

PROCESSES FOR CLAY EXFOLIATION AND USES THEREOF

Crop Enhancement, Inc., ...

1. A method for producing exfoliated clay platelets from a swellable clay material, comprising:providing an exfoliating formulation comprising an anionic extractant, wherein the exfoliating formulation has a basic pH, and wherein the anionic extractant is sodium phosphate monobasic dihydrate, and
contacting the swellable clay material with the exfoliating formulation, wherein the exfoliating formulation produces exfoliated clay platelets from the swellable clay material.

US Pat. No. 10,364,531

DUST HOOD

Brunn Air Systems, Inc., ...

1. A dust hood, comprising:a hood body having a roof and first and second long sidewalls that depend from opposite edges of the roof, the roof forming a peak line;
a first inlet extending substantially the entirety of the first long sidewall, the first inlet having a substantially constant height;
a second inlet extending substantially the entirety of the second long sidewall, the second inlet having a substantially constant height; and
an outlet.

US Pat. No. 10,364,530

BELOW-WEB DUST HOOD

Brunn Air Systems, Inc., ...

1. A dust hood, comprising:a hood body that tapers down in height from a first end face toward a second end face;
an outlet in the hood body;
an inlet provided in a top face of the hood body, the inlet increasing from a minimum width closest to the outlet to a maximum width farthest from the outlet, such that the inlet is broadest where the hood body is shortest and narrowest.

US Pat. No. 10,364,529

SPLITTING METHOD

Compagnie Generale des Et...

1. A method for manufacturing at least first and second assemblies of M1 filamentary elements and M2 filamentary elements, respectively, at least one of the first and second assemblies including a plurality of filamentary elements wound together in a helix, the method comprising steps of:assembling M filamentary elements together into a layer of the M filamentary elements around a temporary core, to form a temporary assembly; and
splitting the temporary assembly into at least the first and second assemblies of M1 filamentary elements and M2 filamentary elements, respectively,
wherein during the step of splitting the temporary assembly, the first assembly is separated from a temporary collection formed of the second assembly and the temporary core, and then the second assembly and the temporary core are separated from each other.

US Pat. No. 10,364,528

ROPE AND METHOD OF MANUFACTURING THE SAME

NATIONAL INSTITUTE OF ADV...

1. A rope including a yarn twisted by using a raw thread of a polyethylene fiber having an ultrahigh molecular weight and a strand twisted by the yarn and subjected to rope-making through the strand,wherein an oil content is removed from the yarn and an affinity enhancing treatment is performed over a surface of the yarn,
a resin coating layer for protecting the rope is formed on an external surface of the yarn, an external surface of the strand or an external surface of the rope,
the resin coating layer is configured to bind the raw thread in an inner part of the yarn, and
the affinity enhancing treatment includes a UV treatment method or an atmospheric plasma method to cause an oxidation reaction over an exposed surface of the polyethylene fiber of the yarn and thereby to cause introduction of an oxygen containing functional group, O, OH, or a combination thereof, to CH that is included in a chemical formula of the polyethylene fiber of the yarn.

US Pat. No. 10,364,527

BURN PROTECTIVE MATERIALS

1. A protective garment having resistance to a flame, and defining an enclosed inner area for a human subject and an exterior area outside the protective garment, said protective garment comprising:a thermally protective laminate comprising:
a flammable, meltable outer textile having an inner surface facing the inner area and an outer surface facing the exterior area;
a thermally stable convective barrier positioned directly on and bonded to said inner surface of said outer textile by a heat reactive material; and
said heat reactive material comprising:
a polymer resin-expandable graphite mixture of a crosslinked polymer and an expandable graphite,
a thermally stable textile backer bonded to said convective barrier on a side opposing said heat reactive material,
wherein said thermally protective laminate is oriented such that said flammable, meltable outer textile is exposed to the exterior area outside the protective garment and said polymer resin-expandable graphite mixture is positioned between the flammable, meltable outer textile and the enclosed inner area.

US Pat. No. 10,364,526

SYSTEM TO PRESSURIZE WATERIN A GARMENT CARE DEVICE

KONINKLIJKE PHILIPS N.V.,...

1. A system for a garment care device comprising:a steam generator;
a chamber for receiving water from a water supply system and for delivering the water towards the steam generator; and
an actuator cooperating with a retention member inside the chamber,
the actuator being configured to load the retention member when the water is received in the chamber, and
the retention member being configured to unload and apply a force to the actuator to pressurise the water received in the chamber, wherein the retention member has a stiffness coefficient (k) that varies as a function of displacement of the actuator from a loaded state of the retention member.

US Pat. No. 10,364,525

LAUNDRY TREATING APPLIANCE LINT FILTER

Whirlpool Corporation, B...

1. A method of removing lint from drying air in a laundry treating appliance having a treating chamber for holding clothes for treatment according to a cycle of operation, a treating chemistry dispenser having a housing with a port fluidly coupled to the treating chamber, a lint filter comprising a bath tub located within the treating chemistry dispenser, the lint filter defined by a portion of the housing and a retaining wall and fluidly coupled with the port, and an air supply having an inlet and outlet fluidly coupled to the treating chamber, the method comprising:a laundry treating phase comprising supplying treating chemistry from the treating chemistry dispenser to the treating chamber and leaving a portion of the treating chemistry within the bath tub to form a bath of treating chemistry;
a laundry drying phase comprising:
supplying air to the treating chamber through the inlet;
exhausting the supplied air from the treating chamber; and
directing the exhausted air to the lint filter within the treating chemistry dispenser to flow over the bath of treating chemistry to remove lint contained within the exhausted air.

US Pat. No. 10,364,524

LAUNDRY TREATING APPLIANCE WITH HELICAL CLUTCH

Whirlpool Corporation, B...

1. A laundry treating appliance comprising:a rotatable basket with a spin tube;
a rotatable clothes mover located within the rotatable basket;
a motor having a drive shaft extending through the spin tube and operably coupled to the clothes mover;
a drive system selectively rotatably coupling the spin tube and the drive shaft and comprising:
a first threaded ring located about the spin tube;
a second threaded ring threaded about the first threaded ring wherein at least one of the first threaded ring or the second threaded ring is axially moveable relative to the other; and
a gear assembly rotationally coupled to the drive shaft;
wherein rotation of the drive shaft is configured to axially move the at least one of the first threaded ring or the second threaded ring and
when either the first threaded ring or the second threaded ring abuts a stop, continued rotation in a same direction results in the spin tube and drive shaft being locked together for coupled rotary motion of the clothes mover and the basket.

US Pat. No. 10,364,523

LAUNDRY TREATMENT APPARATUS

LG Electronics Inc., Seo...

1. A laundry treatment apparatus comprising:a tub body that defines a space that is configured to receive water;
a tub cover that covers an upper surface of the tub body, the tub cover defining an introduction aperture;
a drum that is located inside the tub body and that defines a storage space that is configured to receive laundry;
a door that is configured to open and close the introduction aperture; and
a sealing unit that is located at the door and that is configured to seal the introduction aperture based on the introduction aperture being closed by the door,
wherein the sealing unit includes a sealing body that is configured to, based on the introduction aperture being closed by the door, be positioned between the door and the tub cover to thereby seal the introduction aperture, and a body fixing portion that extends from an upper portion of the sealing body toward a bottom surface of the door, that is coupled to the door, and that has a cross section in a beam shape that extends toward the bottom surface of the door, and
wherein a cross section of the sealing body has a C-shape having an open side.

US Pat. No. 10,364,522

WASHING MACHINE AND METHOD OF CONTROLLING THE SAME

LG ELECTRONICS INC., Seo...

1. A washing machine comprising:a tub configured to contain water;
a basket provided in the tub and rotatable about a vertical axis, the basket having an opening formed in a bottom thereof to allow the basket to communicate with the tub, and a plurality of through holes formed in a side wall thereof through which water flows laterally;
a pulsator rotatably provided at a lower portion of the basket;
a filter to filter water that flows from the tub to the basket through the opening during rotation of the pulsator;
a water supply valve to supply water to the tub;
a water discharge pump to discharge water from the tub;
a drive mechanism to drive at least one of the pulsator and the basket; and
a controller configured to control the water supply valve to be opened for water supply, controls the drive mechanism to rotate at least one of the pulsator and the basket so as to treat laundry introduced into the basket, controls the water discharge pump to discharge water used in the treatment of the laundry, and controls the drive mechanism to rotate the basket while the water is discharged by the water discharge pump.

US Pat. No. 10,364,521

OPERATING METHOD FOR WASHING MACHINE

LG ELECTRONICS INC., Seo...

1. A method of operating a washing machine having a pulsator rotatably provided in a tub, the method comprising:a divisional rotation mode having:
a first divisional rotation process of rotating the pulsator with a first end angle in one direction around a rotation shaft; and
a second divisional rotation process of rotating the pulsator with a second end angle in the other direction around the rotation shaft, wherein the first end angle is greater than the second end angle,
wherein the first divisional rotation process divides the first end angle into at least two angles to rotate the pulsator in the one direction, and
wherein the second divisional rotation process divides the second end angle into at least two angles to rotate the pulsator in the other direction,
wherein the first divisional rotation process includes suspending the pulsator between the two divided angles of the first end angle, and the second divisional rotation process includes suspending the pulsator between the two divided angles of the second end angle.

US Pat. No. 10,364,519

SLIDE SPRING, SLIDE, SLIDE NEEDLE, GUIDE ARRANGEMENT, AND METHOD FOR PRODUCING AT LEAST ONE SLIDE SPRING

Groz-Beckert KG, Albstad...

1. A slider spring for a slider used with a slider needle, the slider spring comprising:a closing section for closing a hook opening of the slider needle;
a connection section for connecting to a slider body of the slider; and
a guide section for guiding the slider spring at a needle body;
wherein the slider spring extends in a spring longitudinal direction, in a spring transverse direction, and in a spring height direction; and
at least one groove-like shaped reinforcement bead with a concave bead interior and an oppositely disposed convex bead exterior;
the slider spring shaped and configured to be stacked against at least one other slider spring such that the convex bead exterior of the slider spring fits completely within the respective concave bead interior of the at least one other slider spring.

US Pat. No. 10,364,518

INTEGRALLY WOVEN OR KNITTED TEXTILE WITH POUCH AND METHODS OF MAKING THE SAME

ATEX Technologies, Inc., ...

1. An integrally woven or knitted textile having a first end, a second end and a length there between, comprising:at least one longitudinal textile portion woven or knitted from a set of yarns; and
at least one pouch or flap woven or knitted from at least a portion of said set of yarns and integrally woven or knitted with the longitudinal textile portion;
wherein, if integrally woven, the set of yarns comprises at least one set of warp yarns or ends and at least one set of weft yarns or picks;
wherein, if integrally knitted, the set of yarns comprises at least one set of wale yarns and at least one set of course yarns;
wherein the at least one pouch is a first pouch having an outer wall, an inner tubular wall and an open inner space, positioned near the first end of the textile;
wherein the first pouch has a slit opening positioned parallel to a longitudinal axis of the textile; and
wherein the slit opening is woven or knitted in the outer wall of the first pouch and extends across the first pouch.

US Pat. No. 10,364,517

ARTICLE OF FOOTWEAR HAVING AN UPPER INCORPORATING A KNITTED COMPONENT

NIKE, Inc., Beaverton, O...

1. An upper for an article of footwear, the upper comprising:a knitted component formed of unitary knit construction,
the knitted component comprising a first knitted layer and a second knitted layer that are at least partially coextensive with each other,
the first knitted layer comprising a first yarn comprising a thermoplastic polymer material, the second knitted layer comprising a second yarn comprising a second material,
wherein a melting temperature of the thermoplastic polymer material is at least five degrees celsius lower than a melting temperature of second material; and
a component secured to the knitted component.

US Pat. No. 10,364,516

3D WOVEN FIBER STRUCTURE, A FIBER PREFORM OBTAINED FROM SUCH A FIBER STRUCTURE, AND A COMPOSITE MATERIAL PART INCLUDING SUCH A PREFORM

Safran Aircraft Engines, ...

1. A fiber structure woven by three-dimensional weaving with a plurality of layers of warp yarns interlinked by weft yarns of a plurality of layers of weft yarns, the fiber structure comprising:a first portion and a second portion situated to be extending along and adjacent each other in a weft direction when not folded relative to each other, and the first portion and the second portion being foldable relative to each other to form an angle at a fold zone,
wherein, in the fold zone and in each weft plane of the fiber structure, two weft yarns situated in a region adjacent to an outside face of the fiber structure situated on an inside of the angle have paths that cross so that arrangements of said two weft yarns in the first and second portions are interchanged, and
wherein in each of the first portion and the second portion, all of the warp yarns are interlinked by three-dimensional weaving by the weft yarns so as to be free of a non-interlinked zone.

US Pat. No. 10,364,513

RADIATION PROTECTIVE MATERIAL

Ten Medical Design AB, O...

1. A radiation protective material, comprising:at least one layer of fibrous material with composite filaments, wherein the filaments are structured in a regular pattern to form the radiation protective material, wherein the filaments comprises a radiopaque composite material including a radiopaque substance, wherein the radiopaque substance is mixed within the composite material and substantially evenly distributed within the composite material, wherein the radiopaque substance is substantially evenly distributed over the entire cross section of the filament, from a center to a surface of the filament, and said filaments are made of a mixture of the radiopaque substance and an organic polymer matrix, such that radiopaque substance is embedded within the organic polymer matrix, wherein the radiopaque substance comprises at least one metal in oxidized form, elemental form, as an alloy, or in salt form in combination with the organic polymer matrix, and wherein the organic polymer matrix comprises at least one of polyvinyl, polyolefin, and polyacetate;
wherein the fibrous material is a woven regular pattern having 15-30 filaments per centimeter;
wherein an amount of the radiopaque substance of the filaments is more than 25% by weight less than 90% by weight of the total weight of the filaments;
wherein each filament forms a single filament yarn;
wherein the fibrous material comprises a first group of filaments and a second group of filaments, wherein the filaments of the first group are arranged in parallel in a first plane with gaps in-between the filaments of the first group, and the filaments of the second group are arranged in parallel in a second plane with gaps in-between the filaments of the second group, and wherein gaps are provided to permit airflow between a filament of the first group and neighboring filaments of the second group, and wherein each filament of the second group has a diameter sized to partially overlap two filaments of the first group along the length of the filaments and to cover the gap between the two filaments of the first group,
the filaments have a diameter in the range of 0.5 mm to 1.5 mm; and
wherein said combination of woven regular pattern, filaments per centimeter, amount of radiopaque substance and filament diameter together provide said at least one layer with a radiopacity that permits penetration of not more than about 60% of X-ray radiation when exposed at 100 kV and 10 mAs charge in combination with a water-vapor resistance of up to 25 Ret.

US Pat. No. 10,364,511

MAGNETO DIELECTRIC COMPOSITE MATERIALS AND MICROWAVE APPLICATIONS THEREOF

UCHICAGO ARGONNE, LLC, C...

1. A substrate for receiving microwave signals comprising:a base layer having tunable elements; and
a nanofiber layer comprising magnetic nanofibers;
wherein said nanofibers have an aspect ratio of length to diameter of each nanofiber is at least 50 to 1; and wherein said nanofiber layer is embedded in the base layer.

US Pat. No. 10,364,510

SUBSTRATE FOR CRYSTAL GROWTH HAVING A PLURALITY OF GROUP III NITRIDE SEED CRYSTALS ARRANGED IN A DISC SHAPE

SCIOCS COMPANY LIMITED, ...

1. A substrate for crystal growth having a holding plate attached to a surface thereof, used for a vapor phase growth of a crystal,wherein a plurality of seed crystal substrates made of a group III nitride crystal are arranged in a disc shape, so that their main surfaces are parallel to each other and adjacent lateral surfaces are in contact with each other;
the plurality of seed crystal substrates constituting at least a portion other than a peripheral portion of the substrate for crystal growth respectively has a main surface whose planar shape is a regular hexagon; and
a surface of the seed crystal substrates are fixed on said holding plate through an adhesive agent, the holding plate has recessed grooves provided on a main surface of the holding plate and at positions facing positions where the lateral surfaces of the adjacent seed crystal substrates are in contact with each other, to allow the adhesive agent to escape.

US Pat. No. 10,364,509

ALKYL PUSH FLOW FOR VERTICAL FLOW ROTATING DISK REACTORS

Veeco Instruments Inc., ...

1. A method of treating substrates comprising:rotating a substrate support about an axis while supporting one or more substrates on said support so that one or more surfaces of the substrates to be treated lie substantially perpendicular to said axis; and
introducing a reactant gas and a carrier gas into said chamber so that said gases flow within said chamber toward said one or more surfaces in one or more streams having substantially uniform velocity at different radial distances from said axis so that different portions of said one or more surfaces at different radial distances from said axis receive substantially the same amount of said reactant gas per unit time per unit area; and,
mixing at least some of said reactant gas with said carrier gas so that gas flowing toward radially outward portions of said one or more surfaces has a higher concentration of said reactant gas than gas flowing toward radially inward portions of said one or more surfaces.

US Pat. No. 10,364,508

METHOD FOR PRODUCING SINGLE CRYSTALLINE ZINC OXIDE NANOPARTICLES

M. TECHNIQUE CO., LTD., ...

1. A method for producing single crystalline zinc oxide nanoparticles comprising:preparing a zinc oxide separating solvent by homogeneously mixing an acidic substance with a solvent containing at least alcohol;
mixing, between processing surfaces which are disposed facing each other so as to be able to approach and separate from each other and at least one of which rotates relative to the other, the prepared zinc oxide separating solvent and a raw material solution that is obtained by mixing a zinc oxide nanoparticle raw material with a basic solvent, or that is basic as a result of mixing and dissolving a zinc oxide nanoparticle raw material with and into a solvent; and
discharging a mixed fluid in which zinc oxide nanoparticles have separated out from between the processing surfaces, wherein
the zinc oxide separating solvent and the raw material solution are mixed between the processing surfaces so that the mixed fluid becomes basic, and
zinc oxide nanoparticles are generated under an acid-base reaction due to mixing of the acidic substance and the raw material solution.

US Pat. No. 10,364,507

NANOPORE FORMING METHOD AND USES THEREOF

Ecole Polytechnique Feder...

1. A method of forming a nanopore in a layer of transition metal dichalcogenide crystals residing between a first electrode on a first side of the layer of transition metal dichalcogenide crystals and a second electrode on a second side of the layer of transition metal dichalcogenide crystals, wherein a first liquid is disposed on the first side and a second liquid is disposed on the second side, the method comprising:applying a variable voltage across the first electrode and the second electrode such that an aperture is created in the layer of transition metal dichalcogenide crystals;
varying the variable voltage as the aperture widens such that a current having a constant average current level exists between the first electrode to the second electrode, the constant average current level corresponding to a specified diameter of the aperture to be formed in the layer of transition metal dichalcogenide crystals; and
maintaining the current at the constant average current level such that the aperture widens to have the specified diameter, thereby forming the nanopore.

US Pat. No. 10,364,506

ELECTROPLATING APPARATUS WITH CURRENT CROWDING ADAPTED CONTACT RING SEAL AND THIEF ELECTRODE

Applied Materials, Inc., ...

1. Apparatus for electroplating a workpiece having an irregularity, comprising:a vessel for holding an electrolyte;
at least one anode and at least one current thief electrode in the vessel;
a workpiece chuck having a contact ring including a seal, with the contact ring and/or the seal having a change in shape at the irregularity which increases the exposure of the irregularity to the current thief electrode, to reduce electric current crowding at the irregularity; and
a head adapted for holding and releasing the workpiece chuck, and for moving the workpiece chuck into and out of the vessel.

US Pat. No. 10,364,505

DYNAMIC MODULATION OF CROSS FLOW MANIFOLD DURING ELECROPLATING

Lam Research Corporation,...

1. An electroplating apparatus comprising:(a) an electroplating chamber configured to contain an electrolyte and an anode while electroplating metal onto a substantially planar substrate;
(b) a substrate holder configured to hold the substantially planar substrate such that a plating face of the substrate is separated from the anode during electroplating, the substrate holder comprising a cup that supports the substrate at its periphery;
(c) an ionically resistive element including a substrate-facing surface that is separated from the plating face of the substrate by a gap of about 10 mm or less, the gap forming a cross flow manifold between the ionically resistive element and the substrate,
wherein the ionically resistive element is at least coextensive with the plating face of the substrate during electroplating, and wherein the ionically resistive element is adapted to provide ionic transport through the ionically resistive element during electroplating;
(d) a side inlet to the cross flow manifold for introducing electrolyte to the cross flow manifold;
(e) a side outlet to the cross flow manifold for receiving electrolyte flowing in the cross flow manifold,
wherein the side inlet and side outlet are positioned proximate azimuthally opposing perimeter locations on the plating face of the substrate during electroplating, and wherein the side inlet and side outlet are adapted to generate cross flowing electrolyte in the cross flow manifold; and
(f) a sealing member for wholly or partially sealing one or more outlets to the cross flow manifold other than the side outlet, wherein the sealing member is positioned at least partially below the cup of the substrate holder, and wherein when the sealing member is engaged the apparatus is in a sealed state, and when the sealing member is not engaged the apparatus is in an unsealed state; and
(g) a controller configured to cause intermittently switching between the sealed state and the unsealed state during electroplating.

US Pat. No. 10,364,504

FABRICATION OF MULTILAYERED NANOSIZED POROUS MEMBRANES AND THEIR USE FOR MAKING NOVEL NANOSTRUCTURES

UNIVERSITY OF HOUSTON, H...

1. A method for fabricating a nanostructure utilizing a multilayer porous membrane as a template, the method comprising:selecting a first layer for a multi-layer arrangement, wherein the first layer comprises a first material;
depositing a second layer on the first layer without bonding via inter-diffusion, wherein the first or second layer is mica, the second layer comprises a second material with an etch rate or an ionization potential that is different from the first material, and the multi-layer arrangement formed is freestanding;
irradiating the freestanding multi-layer arrangement once with high energy and subsequently etching the arrangement once via nuclear track processing to form one or more pores spanning through an entire thickness of both the first layer and second layer of said arrangement to form a multilayer porous template, wherein each of the one or more pores created by the irradiating and the etching steps provides cylinders or nanowires with more than one diameter; and
depositing a nano structure material in and through the one or more pores of the multi-layer template to form a nanostructure, wherein the nanostructure has a shape corresponding to the cylinders or nanowires with more than one diameter.

US Pat. No. 10,364,503

MEDICAL GAS-LIQUID SUPPLY SYSTEM

YUAN ZE UNIVERSITY, Taoy...

1. A medical gas-liquid supply system, comprising:an electrolytic gas generator;
a pure water supply system connected to the electrolytic gas generator for supplying water to the electrolytic gas generator;
a control unit electrically connected to the electrolytic gas generator, wherein the control unit controls the voltage value of the electrolytic gas generator for controlling the type of gases generated by the electrolytic gas generator;
a first gas storing unit communicated to the electrolytic gas generator for storing a first gas output by the electrolytic gas generator;
a second gas storing unit communicated to the electrolytic gas generator for storing a second gas output by the electrolytic gas generator; and
a gas output unit communicated to the first gas storing unit and the second storing unit, wherein the gas output unit has a first output end for outputting the first gas, a second output end for outputting a mixed gas and a third output end for outputting the second gas, wherein the mixed gas comprises the first gas and the second gas.

US Pat. No. 10,364,502

COMPOSITE HARDWARE FOR AN ELECTROCHEMICAL CELL

ITM POWER (RESEARCH) LIMI...

1. A composite cell plate comprising a polymer element laterally mated and interlocked, at a plurality of engagement points, with a tightly fitting resilient metal element,wherein the cell plate is circular,
wherein the polymer element is a hollow ring-shape, and
wherein the polymer element comprises a plurality of protrusions, which engage and interlock with corresponding apertures in the resilient metal element, at the engagement points.

US Pat. No. 10,364,501

PROCESS FOR THE RAPID BLACKENING OF SURGICAL NEEDLES

Ethicon, Inc., Somervill...

1. A method of blackening surgical needles, comprising the steps of:A. placing at least one surgical needle having an outer surface into a pretreatment bath, wherein the pretreatment bath comprises:
about 10 wt. % to about 20 wt. % of water soluble chloride salt;
about 5% to about 15 wt. % of inorganic acid;
about 65 wt. % to about 80% of water,
wherein the pretreatment bath has a pH of about 0.5 to about 1.2; and,
B. then placing the surgical needle into a blackening bath, wherein the bath comprises:
about 3 wt. % to about 20 wt. % of a highly soluble nitric acid salt;
about 18 wt. % to about 38 wt. % of a strong base;
about 50 wt. % to about 75 wt. % of water;
about 0.2 wt. % to about 5 wt. % of a transition metal salt of a strong acid;
about 0.2 wt. % to about 5 wt. % of a sulfur-containing reducer compound; and,
C. maintaining the needle in the blackening bath for a sufficiently effective period of time to provide a blackened coating on the outer surface of the needle.

US Pat. No. 10,364,500

COMPOSITIONS AND METHODS FOR FORMING ARTICLES HAVING SILVER METAL

EASTMAN KODAK COMPANY, R...

1. A non-aqueous precursor composition consisting essentially of:(a) a silver complex comprising one or more reducible silver ions complexed with an ?-oxy carboxylate and a primary alkylamine compound,
the silver complex being represented by the following formula (I):
wherein L represents the ?-oxy carboxylate; P represents the primary alkylamine; a is 1 or 2; b is 1 or 2; and c is 1, 2, 3, or 4, provided that when a is 1, b is 1, and when a is 2, b is 2;(b) a hydroxy-free, nitrile-containing aprotic solvent having a boiling point at atmospheric pressure of at least 100° C. and less than 500° C.; and
(c) a polymer that is either (1) a hydroxy-containing cellulosic polymer or (ii) a non-cellulosic acrylic polymer having a halo- or hydroxy-containing side chain, which polymer is present in an amount of at least 0.25 weight % and up to and including 15 weight %, based on the total weight of reducible silver ions in the silver complex.

US Pat. No. 10,364,499

ROLL

LG CHEM, LTD., Seoul (KR...

1. A roll to transfer a substrate, comprising:a) two ends without a central portion so that only the two ends are in contact with the substrate;
b) a protruding portion provided at each of the two ends of the roll at a surface that contacts the substrate, the protruding portion configured to fix the substrate during the transferring process, the protruding portion having a comb shape comprising lines that form an angle larger than 0° and less than 90° with respect to a transferring direction of the substrate to transfer the substrate while applying a tensile force to the substrate during the transferring process of the substrate; and
c) one or more spraying orifices configured to spray a precursor onto the substrate during a transferring process of the substrate, the spraying orifices located at an inner planar side surface of each of the two ends.

US Pat. No. 10,364,498

GAS SUPPLY PIPE, AND GAS TREATMENT EQUIPMENT

KABUSHIKI KAISHA TOSHIBA,...

4. Gas treatment equipment comprising:a treatment chamber containing a treatment target;
a gas supply pipe configured to supply a gas into the treatment chamber; and
a gas supply source connected to an inflow opening of the gas supply pipe, the gas supply pipe comprising
a first gas pipe having the inflow opening into which the gas flows and having first gas blow holes arranged apart from one another along a longitudinal direction, and
a second gas pipe provided coaxially with the first gas pipe, the second gas pipe having second gas blow holes arranged apart from one another along the longitudinal direction, and allowing the gas to flow in a direction opposite to the first gas pipe, wherein
each of the first gas blow holes corresponds to two or more of the second gas blow holes, forming a set of blow holes;
in each set of blow holes, the first gas blow hole is sandwiched by the two or more second gas blow holes;
two or more sets of blow holes are arranged apart from one another in the first gas pipe and the second gas pipe; and
the first gas blow holes and the second gas blow holes allow the gas to blow therefrom toward a center of the treatment target.

US Pat. No. 10,364,497

VAPOR BASED SITE-ISOLATED PROCESSING SYSTEMS AND METHODS

INTERMOLECULAR, INC., Sa...

1. A method for processing a substrate, the method comprising:providing a substrate;
positioning a showerhead above the substrate, wherein the showerhead comprises a plurality of injection ports, at least one isolation channel, and at least one exhaust port on a bottom surface thereof, wherein the at least one isolation channel separates the plurality of injection ports into two or more sections, wherein at least one of the two or more sections is a planar surface including a plurality of injection ports disposed in an array along a first axis and a second axis of the planar surface, the at least one exhaust port is positioned within the at least one isolation channel, and the plurality of injection ports are not in fluid communication with the at least one exhaust port within the showerhead;
causing at least one processing fluid to be delivered from the plurality of injection ports onto the substrate;
causing at least some of the at least one processing fluid to be removed from the substrate through the at least one exhaust port;
wherein the at least one isolation channel comprises an isolation wall extending from the bottom surface of the showerhead, and wherein a distance between a lower end of the isolation wall and the substrate is less than a distance between the plurality of injection ports and the substrate; and
wherein the showerhead further comprises at least one processing fluid channel formed therein, each of the at least one processing fluid channels being in fluid communication with the injection ports of a respective one of the two or more sections of injection ports, and wherein the causing of the at least one processing fluid to be delivered from the plurality of injection ports onto the substrate comprising delivering the at least one processing fluid to the at least one processing fluid channel.

US Pat. No. 10,364,496

DUAL SECTION MODULE HAVING SHARED AND UNSHARED MASS FLOW CONTROLLERS

ASM IP Holding B.V., Alm...

1. A dual section module with mass flow controllers, for processing wafers, comprising:parallel-processing dual process sections integrated together to which different wafers are loaded simultaneously for parallel processing, each being adapted to process a wafer in its interior, wherein the interiors of the dual process sections are isolated and discrete from each other, and all gas lines for wafer-processing coupled gas-fluidically to one of the interior of the dual process sections and all gas lines for wafer-processing coupled gas-fluidically to the other of the interior of the dual process sections correspond to each other and are gas-fluidically coupled to sources of the same gases used in parallel processing, respectively;
a first shared mass flow controller (MFC) shared by the dual process sections and provided in a first gas line branching into two gas lines, at a first branching point, gas-fluidically coupled to the respective interiors of the dual process sections and arranged symmetrically between the dual process sections so that gas for wafer-processing passing through the first shared MFC can enter the dual process sections through the first gas line, said first shared MFC being disposed as a first MFC in said first gas line upstream of the dual process sections;
at least one mass flow controller (MFC) unshared by the dual process sections and provided in a fourth gas line directly coupled to, at a third gas mixing point, a second gas line gas-fluidically coupled to one of the interiors of the dual process sections so that all gas for wafer-processing passing through the unshared MFC can enter the one of the dual process sections through the fourth gas line and the second gas line without passing through the first shared MFC provided in the first gas line, said at least one unshared MFC being disposed as a first MFC in said fourth gas line upstream of said one of the dual process sections;
at least one mass flow controller (MFC) unshared by the dual process sections and provided in a fifth gas line directly coupled to, at a fourth gas mixing point, a third gas line gas-fluidically coupled to the other of the interiors of the dual process section so that all gas for wafer-processing passing through the unshared MFC can enter the other of the dual process sections through the fifth gas line and the third gas line without passing through the first shared MFC provided in the first gas line and without passing through the unshared MFC provided in the fourth gas line, said at least one unshared MFC being disposed as a first MFC in said fifth gas line upstream of said other dual process section;
a first passage-narrowing device which is an orifice gasket or filter, disposed on one of the two gas lines branched off at the first branching point from the first gas line, the first passage-narrowing device placed downstream of the first branching point and upstream of a first gas mixing point, wherein the second gas line is directly coupled to the one of the two gas lines branched off from the first gas line at the first gas mixing point;
a second passage-narrowing device which is an orifice gasket or filter, disposed on the other of the two gas lines branched off at the first branching point from the first gas line, the second passage-narrowing device placed downstream of the first branching point and upstream of a second gas mixing point, wherein the third gas line is directly coupled to the other of the two gas lines branched off from the first gas line at the second gas mixing point, wherein the two gas lines branched off at the first branching point from the first gas line, including the first passage-narrowing device and second passage-narrowing device and the first gas mixing point and second gas mixing point, are arranged symmetrically between the dual process sections,
wherein the second and third gas lines are gas lines branched off at a second branching point from a sixth gas line;
the fourth and fifth gas lines are gas lines branched off from a source gas line upstream of the respective unshared MFC's provided in the fourth and fifth gas lines; and
a controller configured to control operation of the first passage-narrowing device and the second passage-narrowing device, the controller causing the first passage-narrowing device and the second passage-narrowing device to evenly distribute the gas to the first gas mixing point and the second gas mixing point;
wherein the two gas lines branched off at the first branching point from the first gas line in which the first shared MFC is provided are gas-fluidically coupled to respective showerheads of the dual process sections.

US Pat. No. 10,364,495

METHOD FOR PRODUCING A THIN FILM

ADEKA CORPORATION, Tokyo...

1. A method for producing a thin film, the method comprising:introducing, into a deposition chamber in which a substrate is placed, a vapor that has been obtained by vaporizing a material for thin film formation comprising an aluminum compound represented by general formula (I):

wherein R1 and R2 each independently represent a branched alkyl group having 3 to 5 carbon atoms, and R3 represents a methyl group or an ethyl group; and
forming an aluminum-containing thin film on a surface of the substrate by decomposing and/or chemical reacting the aluminum compound.

US Pat. No. 10,364,494

SUBSTRATE PROCESSING APPARATUS

EUGENE TECHNOLOGY CO., LT...

1. A substrate processing apparatus comprising:a substrate boat in which a substrate is loaded;
a reaction tube in which a processing process for the substrate loaded in the substrate boat is performed;
a gas supply unit configured to supply a process gas into the reaction tube through a plurality of injection nozzles vertically disposed on one side of the reaction tube;
a heating unit comprising a plurality of vertical heating parts disposed along a circumference of the reaction tube to surround the circumference of the reaction tube; and
a control unit configured to control the heating unit;
wherein the plurality of vertical heating parts comprise:
a first vertical heating part disposed at a position corresponding to the injection nozzle; and
a second vertical heating part extending along the circumference of the reaction tube from one side to the other side of the first vertical heating part,
wherein the first vertical heating part and the second vertical heating part surround the circumference of the reaction tube
and respectively heat a region corresponding to the injection nozzle and other regions having the same height in an inside space of the reaction tube, and
wherein the control unit is configured to control the first vertical heating part and the second vertical heating part so that the region corresponding to the injection nozzle, which has a gas partial pressure greater than the other regions having the same height, has a temperature less than the other regions having the same height.

US Pat. No. 10,364,492

FILM DEPOSITION USING PRECURSORS CONTAINING AMIDOIMINE LIGANDS

APPLIED MATERIALS, INC., ...

1. A method of depositing a metal-containing film, the method comprisingexposing a substrate surface to a metal precursor having a structure represented by formula (I):

wherein R1, R2? and R3 are each independently branched or unbranched, C1-C4 alkyl, C1-C4 allyl, or C6-C10 aryl, R2 is hydrogen, branched or unbranched, C1-C4 alkyl, C1-C4 allyl, or C6-C10 aryl, M is a metal selected from groups 7-10 on the periodic table and copper and L comprises one or more ligands; and
exposing the substrate surface to a co-reagent.

US Pat. No. 10,364,491

PROCESS TO CHEMICALLY MODIFY POLYMERIC MATERIALS BY STATIC, LOW-PRESSURE INFILTRATION OF REACTIVE GASEOUS MOLECULES

Georgia Tech Research Cor...

1. A method comprising:loading a substrate into a vacuum chamber of a chemical vapor infiltration reaction apparatus, the vacuum chamber having a first end and a second end with a high vacuum pump located proximate said second end;
pumping the vacuum chamber to a pressure of from 8 mTorr to 12 mTorr with said vacuum pump;
dosing the substrate with a metalorganic precursor by allowing the metalorganic precursor to flow inside the chamber;
dosing the substrate material with a co-reactant to trap the metalorganic precursor within the substrate material;
creating a static precursor atmosphere inside the chamber;
allowing the substrate to rest in the static precursor atmosphere from 30 seconds to 1 day to form a chemically modified substrate; and
extracting the chemically modified substrate from the vacuum chamber.

US Pat. No. 10,364,490

CHROMIZING OVER CATHODIC ARC COATING

UNITED TECHNOLOGIES CORPO...

1. A chromium-rich cathodic arc coating comprising:a MCrAlY cathodic arc coating on a substrate, wherein M is a metal alloy comprising nickel, cobalt, iron, or a combination thereof and the cathodic arc coating comprises 25 to 50% chromium by weight based on the weight of the MCrAlY; and
a diffused chromide coating atop the MCrAlY cathodic arc coating, wherein the diffused chromide coating has a higher content of chromium than the MCrAlY cathodic arc coating, the combined thickness of the diffused chromide coating and the MCrAlY cathodic arc coating is 2.5 to 3 mil (0.0635 to 0.0762 mm), and the chromium-rich cathodic arc coating has a chromium rich phase with a depth of 0.1 to 2.5 mils (0.00254 to 0.0635).

US Pat. No. 10,364,489

APPARATUS AND METHODS FOR DEPOSITION OF MATERIALS ON INTERIOR SURFACES OF HOLLOW COMPONENTS

The Regents of the Univer...

15. A method comprising:(a) positioning an optical fiber and a target of a material to be deposited on a first region of an interior surface of a hollow component in the hollow component, a first end of the optical fiber coupled to a laser system, and a second end of the optical fiber proximate the target;
(b) depositing the material on the first region of the interior surface of the hollow component by directing a first laser pulse from the laser system through the optical fiber to impinge on the target;
(c) measuring a resistance between the hollow component and the target;
(d) repeating operation (b); and
(e) changing a position of the optical fiber, the target, or both the optical fiber and the target to decrease the resistance between the hollow component and the target when operation (b) is repeated.

US Pat. No. 10,364,488

LINEAR EVAPORATION SOURCE AND DEPOSITION APPARATUS HAVING THE SAME

Samsung Display Co., Ltd....

1. A linear evaporation source comprising:a crucible having a length in a length direction and a width in a width direction, the crucible comprising an internal space between at least two length sides, being open on one side thereof, and configured to store a deposition material;
a plurality of partitions dividing the internal space of the crucible into a plurality of internal spaces, wherein each of the partitions extends between the two length sides and has at least one opening substantially centered between the two length sides in a lower portion thereof and at least one stepped recess formed substantially above and separated from the at least one opening by a portion of the partition;
a nozzle section located on the open side of the crucible and comprising a plurality of nozzles;
a heater configured to heat the crucible; and
a housing configured to accommodate the crucible, the nozzle section, and the heater;
wherein the at least one stepped recess of each partition is facing the nozzle section located on the open side of the crucible, each partition includes a bottom surface, and the opening of each partition is separated from the bottom surface of each partition, wherein for each partition, a width of the at least one stepped recess in the width direction is greater than a width of the at least one opening in the width direction, and wherein an evaporated deposition material is sprayed through each nozzle of the plurality of nozzles, and each nozzle corresponds to each of the plurality of internal spaces divided by the plurality of partitions.

US Pat. No. 10,364,487

HIGH ENTROPY ALLOY HAVING TWIP/TRIP PROPERTY AND MANUFACTURING METHOD FOR THE SAME

13. A manufacturing method for a high entropy alloy having TWIP (twin induced plasticity)/TRIP (transformation induced plasticity) property comprising:preparing a raw material; and
manufacturing the high entropy alloy by alloying the raw material,
wherein in the preparing of the raw material, the raw material is prepared to satisfy the following Chemical Formula, and
a free energy change (?Ghcp-fcc) when a ? austenite phase (fcc) in the manufactured high entropy alloy is phase-transformed into an ? martensite phase (hcp) is 1500 J/mol or less:
NiaCobFecMndCre  [Chemical Formula]
(a+b+c+d+e=100, 1?a?50, 1?b?50, 1?c?50, 17.5?d?50, 10?e?25, and 77a?42b?22c+73d?100e+2186?1500).

US Pat. No. 10,364,486

CARBON-BASED NANOTUBE/METAL COMPOSITE AND METHODS OF MAKING THE SAME

The Penn State Research F...

1. A nanocomposite comprising metal and carbon-based nanotube (CNT), wherein the carbon-based nanotube comprises a doping element selected from the group consisting of boron (B), iron (Fe), zinc (Zn), nickel (Ni), cadmium (Cd), tin (Sn), antimony (Sb), Nitrogen (N) and the combination thereof, and wherein the nanocomposite comprises about 0.00001 wt % to about 40 wt % carbon-based nanotube.

US Pat. No. 10,364,484

METHOD AND ALLOYS FOR LOW PRESSURE PERMANENT MOLD WITHOUT A COATING

Brunswick Corporation, M...

11. A method for low pressure permanent mold casting of metallic objects, the method comprising:preparing a permanent mold casting die, said die devoid of die coating or lubrication along a die casting surface;
preparing a permanent mold casting alloy having 4.2-5.0% by weight copper; 0.005-0.45% by weight iron; 0.20-0.50% by weight manganese; 0.15-0.35% by weight magnesium; 0.045-0.110% by weight strontium; 0.05% by weight maximum nickel; 0.10% by weight maximum silicon; 0.15-0.30% by weight titanium; 0.05% by weight maximum tin; 0.10% by weight maximum zinc; and balance aluminum and wherein the alloy has a die soldering factor equivalent to or greater than 1.1, the die soldering factor defined as (10[Sr]+Mn+Fe);
pushing the alloy into the permanent mold casting die under pressure of 3-15 psi to create a permanent mold casting;
cooling the permanent mold casting; and
removing the permanent mold casting from the die without force;
wherein the permanent mold casting does not solder to the permanent mold die; and
wherein the surface roughness of the casting is ±500 microinches or less.

US Pat. No. 10,364,482

COPPER-ZINC ALLOY, BAND MATERIAL COMPOSED THEREOF, PROCESS FOR PRODUCING A SEMIFINISHED PART COMPOSED OF A COPPER-ZINC ALLOY AND SLIDING ELEMENT COMPOSED OF A COPPER-ZINC ALLOY

WIELAND-WERKE AG, Ulm (D...

1. A copper-zinc alloy consisting of, in % by weight:from 67.5 to 68.3% of Cu,
from 0.43 to 0.46% of Si,
from 1.32 to 1.35% of Mn,
from 0.035 to 0.043% of P,
optionally up to a maximum of 0.5% of Al,
optionally up to a maximum of 0.15% of Ni,
optionally up to a maximum of 0.1% of Fe,
optionally up to a maximum of 0.1% of Pb,
optionally up to a maximum of 0.08% of Sn,
optionally up to a maximum of 0.1% of S,
balance Zn and unavoidable impurities,
characterized in that the alloy has a microstructure which consists of an ?-phase matrix in which inclusions of manganese silicides having a globular shape are present in a proportion of at least 2% by volume and not more than 5% by volume.

US Pat. No. 10,364,481

SINGLE-PHASE ALLOY OF GOLD AND TUNGSTEN

Centre National de la Rec...

1. A homogeneous single-phase alloy comprising, in weight %, N % of gold, M % of Tungsten, with N+M=100, M?8 and N?60.

US Pat. No. 10,364,480

METHOD FOR SMELTING NICKEL OXIDE ORE

SUMITOMO METAL MINING CO....

1. A method for smelting nickel oxide ore, in which a pellet is formed from the nickel oxide ore, and the pellet is heat-reduced to obtain an iron-nickel alloy with a nickel grade of 4% by mass or more, the method comprising:a pellet production step for producing a pellet from the nickel oxide ore, and
a reduction step for applying reduction heat treatment to the resulting pellet in a smelting furnace,
the pellet production step comprising mixing raw materials containing at least the nickel oxide ore and a carbonaceous reducing agent to obtain a mixture, and agglomerating the mixture to form a pellet, wherein a mixed amount of the carbonaceous reducing agent is adjusted so that the amount of carbon is 70% or more and 200% or less when the total combined value of a chemical equivalent required for reducing nickel oxide contained in the resulting pellet into nickel metal and a chemical equivalent required for reducing ferric oxide contained in pellet into ferrous oxide is taken as 100%, and
the reduction step comprising pre-covering the furnace floor of the smelting furnace with a furnace floor carbonaceous reducing agent in an amount that can create a reducing atmosphere in which a metal shell formed at the surface layer portion of the pellet during the reduction heat treatment can be melted before charging the resulting pellet into the smelting furnace, and performing the reduction heat treatment with the pellet loaded onto the furnace floor carbonaceous reducing agent so that a metal particle is formed and a slag is generated in the metal shell formed, and the metal shell is melted.

US Pat. No. 10,364,479

METHOD FOR PRODUCING A LOW-ALLOY STEEL INGOT

SAFRAN AIRCRAFT ENGINES, ...

1. A method of fabricating a low alloy steel ingot, the method comprising:a) melting all or part of an electrode by a vacuum arc remelting method, the electrode, before melting, comprising iron and carbon, the melted portion of the electrode being collected in a crucible thus forming a melt pool within the crucible; and
b) solidifying the melt pool by heat exchange between the melt pool and a cooling fluid, the heat exchange applied serving to impose a mean solidification speed during step b) that is less than or equal to 45 ?m/s and to obtain an ingot of low alloy steel.

US Pat. No. 10,364,477

PROCESSES FOR PRODUCING CONTINUOUS BULK FORMS OF IRON-SILICON ALLOYS AND BULK FORMS PRODUCED THEREBY

Purdue Research Foundatio...

1. A process comprising:deforming a solid body formed of an Fe—Si alloy with a cutting tool in a single step to continuously produce a continuous bulk form from material obtained from the solid body, the continuous bulk form having a longitudinal direction, a continuous cross-sectional form, and a microstructure characterized by a crystallographic texture having <111> and {110} fibers that are inclined relative to the longitudinal direction.

US Pat. No. 10,364,476

METHOD AND DEVICE FOR PRODUCING A PRESS-QUENCHED PART

ThyssenKrupp AG, Essen (...

1. A method for producing a press-quenched part having a rim hole with a collar formed at a periphery of the rim hole, the method comprising:providing a part to be press-quenched, having a rim hole with a collar formed at the periphery of the rim hole;
inserting a temperature-controlled die into the rim hole of the part;
controlling the temperature of the temperature-controlled die such that the temperature of the part in a region of the collar is held above a martensite start temperature of a material from which the part is made;
press-quenching the part either during or after said inserting and controlling steps.

US Pat. No. 10,364,475

WEAR-RESISTANT, SINGLE PENETRATION STAVE COOLERS

MacRae Technologies, Inc....

1. A wear-resistant stave cooler subject to a combination of abrasion, impacts, metallic, corrosion, heat and other effects during its use in a furnace, comprising:a cast copper stave body in which are cast liquid coolant piping, and including a hot face subject to wear during use;
a single steel collar embedded, or otherwise anchored into a backside of the cast copper stave body, and laterally positioned such that the stave cooler will hang on only it straight inside from a single penetration of a steel containment shell, and in which all external piping connections of the liquid coolant piping within are collected together as a single group and routed through the single steel collar; and
a wear protection barrier disposed on the hot face and that is limited to include at least one of horizontal rows of ribs and channels that retain metal inserts or refractory bricks, or pockets that assist in the retention of castable cement and/or accretions frozen in place from a melt, or an application of an area of hardfacing that is welded on in a pattern.

US Pat. No. 10,364,471

TUMOR SUPPRESSOR REC8 AS A BIOMARKER FOR GASTRIC CANCER

The Chinese University of...

1. A method for detecting the methylation status of REC8 gene, comprising the steps of:(1) treating genomic DNA obtained from a biological sample taken from a subject with a bisulfate;
(2) performing an amplification reaction to amplify the treated genomic DNA from step (1) using a primer comprising the nucleotide sequence of SEQ ID NO:11 or 12;
(3) analyzing the product of the amplification reaction from step (2) to determine the methylation status of REC8 gene.

US Pat. No. 10,364,468

SYSTEMS AND METHODS FOR ANALYZING CIRCULATING TUMOR DNA

Seven Bridges Genomics In...

1. A method for analyzing tumor DNA, the method comprising:obtaining a genomic reference graph that represents a plurality of known human genomic sequences, the genomic reference graph comprising a directed graph having vertices and edges stored as objects in a tangible memory subsystem of a computer system, wherein matching homologous portions of the sequences are each represented by a single object and portions that vary are represented as alternate objects, such that each of the plurality of known human genomic sequences is represented as a path in the genomic reference graph;
creating a patient-specific genomic reference graph from the genomic reference graph, the creating comprising: aligning a first set of sequencing reads, obtained by sequencing a sample containing non-tumor DNA from the patient, to the genomic reference graph; identifying mutations relative to the genomic reference graph; and incorporating the identified mutations as alternate objects into the genomic reference graph to create the patient-specific genomic reference graph;
aligning a second set of sequence reads, obtained by sequencing a sample containing cell-free plasma DNA from the patient, to the patient-specific genomic reference graph to find at least one mutation in the cell-free plasma DNA relative to the non-tumor DNA from the patient; and
providing a report that circulating-tumor DNA (ctDNA) in the patient includes the at least one mutation found in the cell-free plasma DNA.

US Pat. No. 10,364,467

USING SIZE AND NUMBER ABERRATIONS IN PLASMA DNA FOR DETECTING CANCER

The Chinese University of...

1. A method of analyzing a biological sample of an organism, the biological sample including nucleic acid molecules originating from normal cells and potentially from cells associated with cancer, wherein at least some of the nucleic acid molecules are cell-free in the biological sample, the method comprising:identifying a plurality of chromosomal regions of the organism, each chromosomal region including a plurality of loci;
for each of a plurality of the nucleic acid molecules in the biological sample:
measuring a size of the nucleic acid molecule; and
identifying a location of the nucleic acid molecule in a reference genome of the organism;
for each of the plurality of chromosomal regions:
identifying a respective group of nucleic acid molecules as being from the chromosomal region based on the identified locations, the respective group including at least one nucleic acid molecule located at each of the plurality of loci of the chromosomal region;
calculating, with a computer system, a respective amount of the respective group of nucleic acid molecules; and
comparing the respective amount to a count reference value to determine a count classification of whether the chromosomal region exhibits an aberration, the count classification for a first chromosomal region of the plurality of chromosomal regions indicating a first aberration;
identifying a first group of nucleic acid molecules as being from the first chromosomal region based on the identified locations;
calculating, with a computer system, a first statistical value of a first size distribution of the first group of nucleic acid molecules;
comparing the first statistical value to a size reference value to determine a size classification of whether the first chromosomal region exhibits the first aberration;
determining a final classification of whether the first chromosomal region exhibits the first aberration using the count classification and the size classification of the first chromosomal region; and
determining whether cancer exists in the organism using the final classification.

US Pat. No. 10,364,464

COMPOSITIONS AND METHODS FOR CO-AMPLIFYING SUBSEQUENCES OF A NUCLEIC ACID FRAGMENT SEQUENCE

The Broad Institute, Inc....

1. A method, comprising:a) providing:
i) a solid substrate that can be attached to at least one nucleic acid sequence bearing an attachment feature;
ii) a plurality of random primers comprising random primers bearing an attachment feature and lacking a universal sequence and random primers that do not bear said attachment feature, wherein the ratio of random primers bearing the attachment feature to random primers not bearing the attachment feature is between 30:70 and 70:30; and
iii) a plurality of nucleic acid fragments, comprising a plurality of subsequences and lacking terminal universal sequences;
b) annealing said plurality of nucleic acid fragments to said plurality of random primers under conditions that generate a plurality of linear amplified nucleic acid fragments incorporating said attachment feature; and
c) combining the solid substrate under conditions that attach the solid substrate, through the attachment feature, with either
(1) the plurality of random primers of (a)(ii) prior to step (b), or
(2) the plurality of linear amplified nucleic acid fragments generated in step (b).

US Pat. No. 10,364,463

COMPOSITIONS, SYSTEMS, AND METHODS FOR DETECTING EVENTS USING TETHERS ANCHORED TO OR ADJACENT TO NANOPORES

Illumina, Inc., San Dieg...

1. A composition, comprising:a nanopore including a first side, a second side, and an aperture extending through the first and second sides; and
a permanent tether including a head region, a tail region, and an elongated body disposed therebetween,
wherein the head region is anchored to a polymerase disposed adjacent to the first side of the nanopore, the tail region extends freely toward the second side of the nanopore, and the elongated body comprises a reporter region movable within the aperture and responsive to a first event occurring adjacent to the first side of the nanopore, wherein the first event includes the polymerase acting upon a first nucleotide, wherein the first nucleotide includes an elongated tag including a moiety that interacts with the tether, wherein the interaction of the moiety with the tether translationally moves the reporter region.

US Pat. No. 10,364,460

REACTION CONTAINER, NUCLEIC ACID ANALYSIS DEVICE, AND NUCLEIC ACID ANALYSIS METHOD

TOPPAN PRINTING CO., LTD....

1. A reaction container, comprising:a base material;
an injection port arranged on the base material;
an analysis well in which a nucleic acid analysis reagent used for a nucleic acid analysis is contained, the analysis well being arranged on the base material and configured to analyze a sample containing a nucleic acid; and
a quantification well in which a quantification reagent configured to specifically detect the nucleic acid is contained, the quantification well being arranged on the base material and configured to quantify an amount of the nucleic acid contained in the sample before an amplification of the nucleic acid,
a flow path arranged on the base material configured to distribute the nucleic acid contained in the sample into the quantification well and the analysis well,
wherein the nucleic acid contained in the sample is directly distributed into the quantification well and the analysis well respectively by the flow path, and
wherein the quantification well is positioned to be closer to the injection port than the analysis well.

US Pat. No. 10,364,457

NANOSCALE IMAGING OF PROTEINS AND NUCLEIC ACIDS VIA EXPANSION MICROSCOPY

Massachusetts Institute o...

1. A method for in situ genomic and transcriptomic assessment of target nucleic acids present in a biological sample comprising the steps of:a) treating the biological sample with a small molecule linker comprising a chemical reactive group capable of covalently binding at least one target nucleic acid and a chemical group that can be incorporated into the a swellable material;
b) permeating the biological sample with a composition comprising precursors of a swellable material;
c) initiating polymerization of the precursors to form a swellable material, wherein the small molecule linker is bound to the at least one target nucleic acid in the biological sample and to the swellable material;
d). subjecting the biological sample to a physical disruption method;
e). swelling the swellable material to form an expanded biological sample;
f). providing at least one oligonucleotide complementary to the at least one target nucleic acid, wherein the at least one oligonucleotide hybridizes to the at least one target nucleic acid; and
g). genomically or transcriptomically assessing the expanded biological sample.

US Pat. No. 10,364,456

METHOD FOR PROCESSING POLYNUCLEOTIDE-CONTAINING SAMPLES

HANDYLAB, INC., Franklin...

1. A method for processing polynucleotide-containing sample, the method comprising:retaining polynucleotides from a sample on a plurality of binding particles in a process chamber under a first set of conditions, wherein the retaining step comprises binding the polynucleotides to the surfaces of the plurality of binding particles comprising a poly-cationic substance, wherein the sample has a volume from 0.5 microliters to 3 milliliters;
wherein the first set of conditions includes a first pH of about 8.5 or less and a first temperature, wherein the first temperature is about 50° C.;
releasing the polynucleotide from the plurality of binding particles under a second set of conditions; and
wherein the second set of conditions includes increasing the pH to a second pH by addition of a hydroxide solution and increasing the temperature to a second temperature, wherein the second temperature is between about 80° C. and about 100° C.

US Pat. No. 10,364,454

BIOLUMINESCENT ASSAYS UTILISING SECRETED LUCIFERASES

GENE STREAM PTY LTD., Ci...

1. A composition for use in determining the amount or activity of at least one luciferase, wherein the composition comprisesa) at least one reducing agent, and
b) a first luciferase that is a secreted enzyme in its native (wild-type) form.

US Pat. No. 10,364,452

STRIP-BASED ELECTROCHEMICAL SENSORS FOR QUANTITATIVE ANALYSIS OF ANALYTES

The Regents of the Univer...

1. An electrochemical sensor, comprising:a substrate formed of an insulative material;
an electrode contingent including a first electrode and a second electrode on the substrate, wherein the first electrode includes a coating of carbon nanotubes (CNTs); and
an entrapment layer formed on the first electrode to attach an enzymatic substance capable of causing a redox reaction in the presence of a target analyte of a fluid sample which produces a redox-active product, wherein the entrapment layer is structured to include a conductive polymer film that is reversibly dopable to conduct charge carriers across the entrapment layer and at the first electrode,
wherein the conductive polymer film includes poly(thionine).

US Pat. No. 10,364,448

METHOD FOR PRODUCING L-?-AMINO ACID COMPOUND

Sumitomo Chemical Company...

1. A method for producing a sulfur containing L-?-amino acid compound of formula (3):
wherein the method comprises:
(I) a step of reacting a protein with a sulfur-containing ?-hydroxycarboxylic acid compound of formula (1) to obtain the corresponding sulfur-containing ?-oxocarboxylic acid compound of formula (2):

wherein the protein is selected from the group consisting of:
(A1) a protein having the amino acid sequence of SEQ ID NO: 5,
(A2) a protein having an amino acid sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 5, wherein the protein has the ability to oxidize and convert the sulfur-containing ?-hydroxycarboxylic acid compound of formula (1) into the corresponding sulfur-containing ?-oxocarboxylic acid compound of formula (2), and
(A3) a protein having the amino acid sequence of SEQ ID NO: 5 in which 1 to 10 amino acids are deleted, substituted, or added, wherein the protein has the ability to oxidize and convert the sulfur-containing ?-hydroxycarboxylic acid compound of formula (1) into the corresponding sulfur-containing ?-oxocarboxylic acid compound of formula (2); and
(II) a step of reacting the sulfur-containing ?-oxocarboxylic acid compound of formula (2) obtained in the step (I) with a protein having the ability to aminate and convert the sulfur-containing ?-oxocarboxylic acid compound of formula (2) into the corresponding sulfur-containing L-?-amino acid compound of formula (3) to thereby obtain the sulfur-containing L-?-amino acid compound of formula (3), wherein the protein is selected from the group consisting of:
(B1) a protein having the amino acid sequence of SEQ ID NO: 7,
(B2) a protein having an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 7, wherein the protein has the ability to aminate and convert the sulfur-containing ?-oxocarboxylic acid compound of formula (2) into the corresponding sulfur-containing L-?-amino acid compound of formula (3), and
(B3) a protein having the amino acid sequence of SEQ ID NO: 7 in which 1 to 36 amino acids are deleted, substituted, or added, wherein the protein has the ability to aminate and convert the sulfur-containing ?-oxocarboxylic acid compound of formula (2) into the corresponding sulfur-containing L-?-amino acid compound of formula (3),
wherein R1 in formula (1), formula (2), and formula (3) is a C1-C8 alkyl group.

US Pat. No. 10,364,427

METHOD OF DNA/RNA EXTRACTION USING SILYATED QUATERNARY AMMONIUM COMPOUNDS (SIQAC)

ARCIS BIOTECHNOLOGY HOLDI...

1. A method of extracting DNA and/or RNA from a cell or capsid, the method comprising contacting the cell or capsid with a composition comprising a quaternary ammonium compound including a silicon-containing functional group of general formula (I):or a derivative salt thereof wherein L is a linking group; each of R1, R2, R3, R4, R5 and R6 is independently selected from H or an optionally substituted alkyl, alkenyl, aryl or alkoxy group; and n is 0 or 1; andwherein the composition is aqueous or dried.

US Pat. No. 10,364,418

3-HYDROXYISOVALERATE (HIV) SYNTHASE VARIANTS

Global Bioenergies, Evry...

1. A 3-hydroxyisovalerate (HIV) synthase variant showing an improved activity in converting acetone and a compound which provides an activated acetyl group characterized by the following formula (I):
into 3-hydroxyisovalerate over the corresponding HIV synthase from which it is derived, wherein X is selected from the group consisting of S—CH2-CH2-NH—CO—CH2-CH2-NH—CO—CH(OH)—C(CH3)2-CH2-O—PO2H—O—PO2H—C10H13N5O7P (coenzyme A), S—CH2-CH2-NH—CO—CH2-CH2-NH—CO—CH(OH)—C(CH3)2-CH2-O—PO2H-polypeptide (acyl-carrier protein), S—CH2-CH2-NH—CO—CH2-CH2-NH—CO—CH(OH)—C(CH3)2-CH2-OH (pantetheine), S—CH2-CH2-NH—CO—CH3 (N-acetyl-cysteamine), S—CH3 (methane thiol), S—CH2-CH(NH2)-CO2H (cysteine), S—CH2-CH2-CH(NH2)-CO2H (homocysteine), S—CH2-CH(NH—C5H8NO3)-CO—NH—CH2-CO2H (glutathione), S—CH2-CH2-SO3H (coenzyme M) and OH (acetic acid), and wherein the HIV synthase variant is derived from the amino acid sequence as shown in SEQ ID NO:1 or an amino acid sequence having at least 80% sequence identity to SEQ ID NO:1, and in which the HIV synthase variant comprises one or more amino acid residues at a position selected from the group consisting of:
(1) an amino acid residue at position 33 in the amino acid sequence shown in SEQ ID NO:1 or at a position corresponding to this position in the sequence from which the HIV synthase variant is derived, is substituted; and/or
(2) an amino acid residue at position 74 in the amino acid sequence shown in SEQ ID NO:1 or at a position corresponding to this position in the sequence from which the HIV synthase variant is derived, is deleted or substituted; and/or
(3) an amino acid residue at position 171 in the amino acid sequence shown in SEQ ID NO:1 or at a position corresponding to this position in the sequence from which the HIV synthase variant is derived, is substituted; and/or
(4) an amino acid residue at position 221 in the amino acid sequence shown in SEQ ID NO:1 or at a position corresponding to this position in the sequence from which the HIV synthase variant is derived, is deleted or substituted; and/or
(5) an amino acid residue at position 222 in the amino acid sequence shown in SEQ ID NO:1 or at a position corresponding to this position in the sequence from which the HIV synthase variant is derived, is deleted or substituted; and/or
(6) an amino acid residue at position 338 in the amino acid sequence shown in SEQ ID NO:1 or at a position corresponding to this position in the sequence from which the HIV synthase variant is derived, is deleted or substituted; and/or
(7) an amino acid residue at position 345 in the amino acid sequence shown in SEQ ID NO:1 or at a position corresponding to this position in the sequence from which the HIV synthase variant is derived, is deleted or substituted; and/or
(8) an amino acid residue at position 394 in the amino acid sequence shown in SEQ ID NO:1 or at a position corresponding to this position in the sequence from which the HIV synthase variant is derived, is deleted or substituted; and/or
(9) an amino acid residue at position 396 in the amino acid sequence shown in SEQ ID NO:1 or at a position corresponding to this position in the sequence from which the HIV synthase variant is derived, is substituted.

US Pat. No. 10,364,413

LARGE SCALE DISPOSABLE BIOREACTOR

Protalix Ltd., Carmiel (...

25. A disposable device for culturing and harvesting plant tissue and/or cells comprising a non-rigid container having a volume of at least 400 liters and being configured with gas exchange ports and a harvesting port enabling said device to be used continuously for at least two consecutive culturing/harvesting cycles, wherein said gas exchange ports include a plurality of gas inlet ports positioned around the perimeter of the container in the lower half of the container, the outlets of said ports into the container having exits into the container that are spaced from an axis of the container; andwherein the device has neither mechanical agitation to mix medium in the container or a sparger to distribute gas bubbles when medium is present therein; and
the exits are adjacent the perimeter of the container at the position of the ports; and
wherein the container is generally cylindrically symmetrical and ports of a first plurality of said plurality of gas inlet ports are positioned at a same first distance from a bottom of the container and spaced from each other.

US Pat. No. 10,364,412

APPARATUS FOR PROVIDING LARGE AMOUNTS OF GAS TO A FERMENTATION BROTH

XYLECO, INC., Wakefield,...

1. A system for delivering air to an aqueous liquid for aerobic fermentation of the aqueous liquid, comprising:a vessel having a length to diameter ratio of less than 2:1 and a volume of at least 10,000 gallons;
an aeration system that maintains a dissolved oxygen concentration of at least 10% in the aqueous liquid, the aeration system including at least one sparge tube having a pore size of less than 5 microns and a porosity of greater than 50 percent in fluid communication with an interior of the vessel;
at least one blower configured to deliver air at a pressure of less than 15 psig to the at least one sparge tube; and
a heat exchanger in fluid communication between the at least one blower and the at least one sparge tube that cools the air to below 100° F. (37.8° C.) prior to entering the at least one sparge tube.

US Pat. No. 10,364,410

METHODS AND APPARATUS FOR SHIFTED-WAVELENGTH PHOTOSYNTHETIC ENERGY HARVESTING AND BIOMASS PRODUCTION

Massachusetts Institute o...

1. A method comprising applying stimuli to a colony of organisms, such that:(a) the stimuli include illuminating the colony with visible light and with light that has a wavelength that is outside of the range of wavelengths of visible light; and
(b) the stimuli, taken together, tend to favor survival of organisms that are adapted to perform photosynthesis which involves absorbing energy from light that has a wavelength that is outside of the range of wavelengths of visible light, wherein the illuminating comprises:
(i) illuminating the entire colony of organisms with green light;
(ii) illuminating a first portion of the colony, but not a second portion of the colony, with ultraviolet light; and
(iii) illuminating the second portion of the colony, but not the first portion of the colony, with infrared light.

US Pat. No. 10,364,408

SYSTEMS AND METHODS FOR MAKING SOAP FLOWERS

Rose LTD, City of Indust...

10. A method of assembling an artificial flower, comprising:stacking a plurality of pliable material sheets;
pressing a first stamp into the plurality of pliable material sheets to produce a column of flower wraps, wherein the column of flower wraps comprises at least two flower wraps and the first stamp comprises a peg, and the first stamp further comprises a shape corresponding to that of the at least two flower wraps;
separating a plurality of individual flower wraps from the column of flower wraps, wherein an individual flower wrap of the plurality of flower wraps comprises a central hub and a plurality of petals,
wherein the plurality of petals extends radially outward from the central hub, and the central hub and the plurality of petals are integrally formed with each other; and
creating an artificial flower construct, wherein creating the artificial flower construct comprises:
wrapping the first flower wrap of the plurality of flower wraps around a core,
folding each of the petals of the first flower wrap around the core,
layering at least a second flower wrap of the plurality of flower wraps around the first flower wrap,
attaching a calyx, and
inserting a flower mounter through the core.

US Pat. No. 10,364,406

HARD SURFACE CLEANERS

1. A liquid hard surface cleaning composition comprising:(a) A hydrophobically modified cationic polymer having the formula:

 wherein:
n, m, p, and s are the mole percent of the respective monomers, such that:
n is from about 80 to about 99.5;
m is from about 0 to about 10;
p is from about 0.25 to about 20;
s is from about 0 to about 10;
m+s is at least about 0.01;
with the proviso that the sum of the mole percentages add up to 100%;
R1, R2, R3, and R4 are independently H or CH3;
R5 is an alkyl group from C7 to C21;
R6, R7, R8, are independently selected from the group consisting of: hydrogen and C1 to C4 alkyl;
Y is independently O or NH;
Z is silicone or a derivative thereof;
k is independently from about 1 to about 18;
X? is an anion, preferably Cl?, Br?, I?, HSO4?, CH3SO4?, C2H5SO4?, or OH?;
and
(b) a detersive surfactant, solvent, or mixtures thereof.

US Pat. No. 10,364,402

LUBRICATING COMPOSITION CONTAINING AN OXYALKYLATED AROMATIC POLYOL COMPOUND

The Lubrizol Corporation,...

1. A lubricating composition comprising an oil of lubricating viscosity and 0.01 wt % to 10 wt % of an oxyalkylated aromatic polyol compound represented by the formula:
wherein
R1 is —(CH2CHR5—O—)mR6,
R2 is hydrogen, a hydrocarbyl group, or —(C?O)R4,
n is 1 or 2,
R3 is a hydrocarbyl group, or —(C?O)R4, or —(CH2CHR5—O—)mR6,
x is 1 to 2,
R4 is a hydrocarbyl group,
R5 is hydrogen or a hydrocarbyl group containing 1 to 4 carbon atoms,
R6 is hydrogen or a hydrocarbyl group, or —(C?O)R7,
R7 is a hydrocarbyl group, and
m=1 to 20.

US Pat. No. 10,364,400

SPENT GRAIN FUEL PRODUCT AND PROCESS

AKBEV GROUP, LLC, Juneau...

1. A process for making a fuel product from spent grain comprising the following steps:in a brewing process pulverizing grain to reduce the particles to median particle size generally within the range of 0.25 mm to 0.6 mm with less than one percent (1%) of the grain particles greater than 2 mm,
after brewing, pressing the spent grain to mechanically remove moisture and other soluble components from the spent grain,
and drying the spent grain to reduce its moisture content to ten percent (10%) or less by weight and
further including the step of combusting the spent grain and agitating the spent grain during this combustion phase to separate particles of the spent grain to inhibit their cohesion into an integrated mass, wherein agitation of the spent grain is effected by spraying the spent grain into a combustion chamber, wherein spraying the spent grain is effected by utilizing a pneumatic stoker,
wherein the process steps recited above renders the spent grain combustible in and of itself as a primary or sole fuel source.

US Pat. No. 10,364,399

HIGH OCTANE UNLEADED AVIATION FUEL

GENERAL AVIATION MODIFICA...

1. A method for manufacture of a high octane unleaded aviation fuel composition, comprising:(a) providing about forty-five percent (45%) to about sixty-five percent (65%) by weight of high octane alkylate having a motor octane number of between ninety-five (95) and one hundred (100);
(b) providing about ten percent (10%) to about thirty-five percent (35%) by weight of one or more alkylated benzenes;
(c) providing about six percent (6%) to about twelve percent (12%) by weight, collectively, of a selected composition of one or more of iso-pentane, n-butane, and iso-butane, wherein the constituent(s) of said selected composition are sufficient that said high octane unleaded aviation gasoline composition has a vapor pressure of between 38 kPa and 49 kPa (between 5.8 pounds per square inch and 7.2 pounds per square inch);
(d) providing about four percent (4%) to about fifteen percent (15%) by weight aromatic amine(s), said aromatic amine(s) comprising N-methyl-p-toluidine and N-methyl-m-toluidine in the ratio of between about four to one (4:1) and about twelve to one (12:1), by weight;
(e) wherein said N-methyl-p-toluidine and said N-methyl-m-toluidine provided in (d) are byproducts of production of o-toluidine, said byproducts comprising m-toluidine and p-toluidine, and wherein said m-toluidine and said p-toluidine are reacted with a selected source of methyl groups to produce N-methyl-p-toluidine and (ii) N-methyl-m-toluidine; and
(f) blending each of the compositions provided in (a), (b), (c), and (d) above to provide a high octane unleaded aviation fuel composition.

US Pat. No. 10,364,398

METHOD OF PRODUCING PRODUCT GAS FROM MULTIPLE CARBONACEOUS FEEDSTOCK STREAMS MIXED WITH A REDUCED-PRESSURE MIXING GAS

ThermoChem Recovery Inter...

1. A method for producing product gas from a carbonaceous material, the method comprising:(a) splitting a source of bulk carbonaceous material into a plurality of carbonaceous material streams;
(b) providing a supply of pressurized mixing gas;
(c) reducing a pressure of the pressurized mixing gas by between 5 psig to 750 psig to form a reduced-pressure mixing gas;
(d) mixing the reduced-pressure mixing gas with each of the plurality of carbonaceous material streams to form a plurality of gas-laden carbonaceous material streams, each having a carbonaceous material to gas weight ratio that is less than about 50:1;
(e) transferring said plurality of gas-laden carbonaceous material streams to a first reactor via a plurality of inlets that are circumferentially spaced apart from one another; and,
(f) endothermically reacting the transferred carbonaceous material with steam in a first reactor to produce a first reactor product gas containing char.

US Pat. No. 10,364,397

MERCURY REMOVAL FROM LIQUID HYDROCARBONS BY 1,4-BENZENEDIAMINE ALKYLDIAMINE CROSS-LINKED POLYMERS

King Fahd University of P...

1. A method for removing mercury from a fluid hydrocarbon comprising contacting the fluid hydrocarbon with a 1,4-benzenediamine-co-alkyldiamine polymer for a time and under conditions sufficient for mercury to bind to the polymer, thereby removing the mercury from the fluid hydrocarbon.

US Pat. No. 10,364,396

METHOD FOR THERMAL CONVERSION OF KETOACIDS AND HYDROTREAMENT TO HYDROCARBONS

NESTE OYJ, Espoo (FI)

1. A method for increasing the molecular weight of ketoacids, the method comprising:a) providing in a reactor a feedstock containing at least 80 wt % of at least one ketoacid; and
b) subjecting the feedstock to one or more C-C-coupling reaction(s) to produce a C-C-coupling reaction product;
wherein the one or more C-C-coupling reaction(s) are conducted by heating the feedstock to a temperature of 205-400° C. in an absence of a catalyst, and wherein the one or more C-C-coupling reaction(s) are conducted mainly in the liquid phase.

US Pat. No. 10,364,395

PYROLYSIS REACTOR SYSTEM FOR THE CONVERSION AND ANALYSIS OF ORGANIC SOLID WASTE

Kuwait Institute for Scie...

1. A pyrolysis reactor system for the conversion and analysis of organic solid waste, comprising:a pyrolysis fixed bed cylindrical reactor for converting organic solid waste into a solid product and a gas-liquid product mixture through pyrolysis, the reactor includes a three-zone furnace wherein each zone provides a temperature of up to 850° C., wherein the reactor includes a collection unit in direct communication therewith to collect the solid product;
a source of carrier gas in contact with the pyrolysis reactor for achieving pyrolytic conditions therein;
a first gas-liquid separator in fluid communication with the pyrolysis reactor and a chiller, the first gas-liquid separator receiving the gas-liquid product mixture directly from the pyrolysis reactor, separating a portion of gas therefrom, and outputting the portion of gas from the first gas-liquid separator for analysis thereof;
a condenser receiving the gas-liquid product mixture directly from the first gas-liquid separator;
a second gas-liquid separator in direct fluid communication with the condenser, the second gas-liquid separator receiving the gas-liquid product mixture therefrom and separating the remainder of the gas therefrom, whereby the remainder of the gas and the separated liquid are each collected separately from one another for analysis thereof; and
a multi-port valve for separating the separated liquid into fractional components for automatic sampling of the liquid.

US Pat. No. 10,364,394

CONVERTER FOR ORGANIC MATERIALS

The Crucible Group Pty Lt...

1. An apparatus for pyrolysing or otherwise processing a solid organic feed material including:(a) a reaction chamber having an upstream end, a downstream end, an inlet for the organic feed material, and separate outlets for a gas product and a dried and pyrolysed solid carbon-containing product produced from the organic feed material in the chamber; and
(b) an assembly for moving the organic material through the reaction chamber from the upstream end towards the downstream end of the chamber counter-current to a flow of gas produced in the chamber;
(c) a supply device for supplying the solid feed material to the reaction chamber that is configured for compressing material within the supply device so that the solid material forms a gas seal, the supply device including (i) two screws on the same axis, (ii) an axial gap between the screws in which feed material is compressed in use of the supply device and (iii) a motor with variable speed capability for independently driving each screw so that in use the downstream screw runs at a slower rotation rate than the upstream screw; and
(d) a discharge device for discharging the solid carbon-containing product from the reaction chamber that is configured for compressing material within the discharge device so that the solid product forms a gas seal.

US Pat. No. 10,364,393

PROCESS AND APPARATUS FOR CONTINUOUS PRODUCTION OF DENSIFIED CHARCOAL

COMMONWEALTH SCIENTIFIC A...

1. An apparatus for the continuous autogenous thermal decomposition of organic material comprising:a reaction vessel for supporting a reaction bed of organic material, the reaction vessel defining a flow path along which the organic material undergoes a carbonisation process via an autogenous pyrolysis reaction as it progresses through the reaction vessel, wherein all of the heat required to sustain the pyrolysis reaction in the material is generated by exothermic pyrolysis reactions in the reaction bed; and
a feeder for supplying organic material to the reaction vessel through an inlet;
the reaction vessel comprising:
a pressure applicator to apply pressure to the reaction bed sufficient to compress and densify the reaction bed;
a reaction zone for autogenous pyrolysis reaction of organic material in the reaction bed to form pyroligneous gases and carbonized organic material;
at least one gas outlet from the reaction zone to extract pyroligneous gases directly from the reaction bed, wherein the at least one gas outlet from the reaction zone includes at least one lance which extends from the discharge end of the reaction vessel;
a heating zone in which the pyroligneous gases formed in the reaction zone are allowed to pass through and heat the organic material;
at least one gas outlet provided above the inlet for the removal of the gases; and
at least one discharge port for discharging the carbonised organic material from the reaction vessel.

US Pat. No. 10,364,392

LIQUID-CRYSTALLINE MEDIUM AND LIQUID-CRYSTAL DISPLAY COMPRISING THE SAME

MERCK PATENT GMBH, Darms...

1. Liquid-crystalline medium having a nematic phase and a dielectric anisotropy (??, at a temperature of 20° C. and a frequency of 1 kHz) of 0.5 or more which comprises:one or more compounds of formula I

in which

n denotes 0 or 1,
R11 denotes R1,
R12 denotes X1,
R1 denotes alkyl, alkoxy, fluorinated alkyl or fluorinated alkoxy alkenyl, alkenyloxy, alkoxyalkyl or fluorinated alkenyl having 2 to 7 C atoms, and
Xl denotes F, Cl, fluorinated alkyl, fluorinated alkenyl, fluorinated alkoxy or fluorinated alkenyoxy;andone or more compounds selected from the group of compounds of formulae II, III, IV and V:

in which
R2 denotes alkyl, alkoxy, fluorinated alkyl or fluorinated alkoxy having 1 to 7 C atoms, alkenyl. alkenyloxy, alkoxyalkyl or fluorinated alkenyl having 2 to 7 C atoms,

on each appearance, independently of one another,

L21 and L22 denote H or F,
X2 denotes halogen, halogenated alkyl or alkoxy having 1 to 3 C atoms or halogenated alkenyl or alkenyloxy having 2 or 3 C atoms,
m denotes 0, 1, 2 or 3,
R3 denotes alkyl, alkoxy, fluorinated alkyl or fluorinated alkoxy having 1 to 7 C atoms, alkenyl, alkenyloxy, alkoxyalkyl or fluorinated alkenyl having 2 to 7 C atoms and

on each appearance, independently of one another, are

L31 and L32, independently of one another, denote H or F,
X3 denotes halogen, halogenated alkyl or alkoxy having 1 to 3 C atoms or halogenated alkenyl or alkenyloxy having 2 or 3 C atoms, F, Cl, —OCF3, —OCHF3, —O—CH2CF3, —O—CH?CF2,—O—CH?CH2 or —CF3,
Z3 denotes —CH2CH2—, —CF2CF2—, —COO—, trans-CH?CH—, trans-CF?CF—, —CH2O— or a single bond, and
n denotes 0, 1, 2 or 3,

in which
R41 and R42, independently of one another, denote alkyl, alkoxy, fluorinated alkyl or fluorinated alkoxy having 1 to 7 C atoms, alkenyl, alkenyloxy, alkoxyalkyl or fluorinated alkenyl having 2 to 7 C atoms,

independently of one another and, if

 occurs twice,
also these independently of one another, denote

Z41 and Z42, independently of one another and, if Z41 occurs twice, also these independently of one another, denote —CH2CH2—, —COO—, trans -CH?CH—, trans-CF?CF—, -CH2O—, —CF2O—, —C?C— a single bond,
P denotes 0, 1 or 2, and
R51 and R52, independently of one another, have one of the meanings given for R41 and R42,

if present, each, independently of one another, denote

z51 to Z53 each, independently of one another, denote —CH2—CH2—, —CH2—O—, —CH?CH—, —C?C—, —COO— a single bond, and
i and j each, independently of one another, denote 0 or 1;
with the condition that the ratio of the dielectric constant perpendicular to the director (??) to the dielectric anisotropy (??), i.e. (??/??) of the medium, is 2.0 or less.

US Pat. No. 10,364,390

HIGH DENSITY FAST PHOSPHOR FOR ELECTRON MICROSCOPY

Gatan, Inc., Pleasanton,...

1. A thin film sensor for emitting light when excited by an electron beam, comprising:a cerium-doped or praseodymium-doped, non-transparent, garnet crystalline phosphor powder comprised of particles having a grain size substantially between 1 and 5 microns,
wherein the thin film sensor has a thickness of 100 ?m or less,
said phosphor having a light output primary decay time to less than a factor of 1/e (˜0.37) of peak light emission at 1 microsecond or less after excitation by the electron beam has ceased, and
said phosphor having an emission efficiency equal to or greater than 25% of phosphor P-43.

US Pat. No. 10,364,389

FLUORESCENT DIAMOND PARTICLES

1. A method of processing diamond particles to form color centers, comprising:a) providing diamond particles having a surface and having a diamond lattice and containing at least one dopant;
b) creating vacancies in the diamond particles by irradiating the diamond particles with high energy radiation;
c) after irradiating the diamond particles, annealing the irradiated diamond particles in at least one of an inert environment and vacuum at a temperature high enough to cause the vacancies to diffuse and combine with the at least one dopant to form color centers;
d) after annealing the irradiated diamond particles, purifying the irradiated and annealed diamond particles to remove sp2 carbon from the surface of the diamond particles;
e) repeating steps b), c) and d) at least once such that the resulting diamond particles with color centers produced using the accumulated irradiation dose have brighter fluorescent intensity than diamond particles with color centers that have been produced by irradiating in a single irradiation run followed by a single annealing and purification sequence; and
f) functionalizing the purified diamond particles with at least one functional group selected from the groups consisting of carboxylic, hydroxyl, amino, epoxy, polyethylene glycol, hydrocarbon chain, hydrocarbon, aromatic, nucleophile, thiol, sulfur, acid, base, and fluoro-containing.

US Pat. No. 10,364,388

PHASE CHANGE FRACTURING FLUID SYSTEM FOR PHASE CHANGE FRACTURING

SOUTHWEST PETROLEUM UNIVE...

1. A phase change fracturing fluid system for phase change fracturing, comprising:a supramolecular construction unit of 10%-40% by weight,
a supramolecular function unit of >0% and ?40% by weight,
a surfactant of 0.5%-2% by weight,
an inorganic salt of >0% and ?5% by weight,
an oxidizing agent of 0.5%-2% by weight,
a cosolvent of >0% and ?2% by weight, and
a solvent of a remaining ratio by weight; and wherein
the supramolecular construction unit is a triallyl isocyanurate;
the supramolecular function unit is a vinyl acetate, an acrylonitrile, or a mixture of the vinyl acetate and the acrylonitrile.

US Pat. No. 10,364,387

SUBTERRANEAN FORMATION SHOCK FRACTURING CHARGE DELIVERY SYSTEM

Innovative Defense, LLC, ...

1. A subterranean formation explosive shape charge alignment and delivery system comprising:a locking device coupled to a depth placement mechanism that controls the depth of the explosive charge alignment and delivery system in a borehole, said locking device having jaws expand to make a locking engagement with one or more walls of the borehole to hold the explosive shaped charge alignment and delivery system at a desired depth position in the borehole, said jaws retract to unlock the engagement of the explosive shaped charge alignment and delivery system with the one or more walls of the borehole;
a plurality of primary segments coupled to the locking device, each of said plurality of primary segments having a plurality of blast chambers, each of said plurality of blast chambers containing an explosive shaped charge with a predetermined measure of explosives in an explosive billet and associated detonation initiation and firing controls, one or more of said explosive shaped charges being separately and independently detonated without detonating one or more of the other explosive shaped charges in the explosive shape charge alignment and delivery system, said detonation occurring without causing fratricide damage to one or more of the other explosive shaped charges or one or more other blast chambers in the explosive shape charge alignment and delivery system;
a plurality of centralizers with one or more said centralizers being deployed between one or more of said plurality of primary segments, each of said centralizers having expansion contacts that provide engagement of the explosive shaped charge alignment and delivery system with one or more walls of the borehole to maintain the position of the blast chambers and explosive shape charges in the borehole and to provide equal and consistent standoff distance between explosive shape charge being detonated and the nearby walls of the borehole;
a linear actuator that is coupled to one or more of said primary segments, said linear actuator capable of adjusting the position of the one or more primary segments in a longitudinal direction up or down the borehole, in a rotational direction radially inside the borehole, or in a horizontal direction side to side in the borehole; said linear actuator:
i. being used to position one of the explosive shaped charges in a blast chamber in one of the primary segments by the depth in the borehole, rotational direction in the borehole, and angle of inclination in the borehole of the explosive shape charge or blast chamber at a first detonation creating a first explosive hole; and,
ii. being used to re-position another one of the explosive shape charges in another blast chamber in one of the primary segments by the depth in the borehole, rotational direction in the borehole, and angle of inclination in the borehole of the explosive shape charge or blast chamber at a second detonation occurring after said first detonation, said explosive shape charge alignment and delivery system substantially aligning the second detonation in an intended and directionally controlled local vicinity of said first explosive hole created by the first detonation to sequentially and successively create a deeper explosive hole with the second detonation.

US Pat. No. 10,364,385

MULTI-TAIL HYDRATE INHIBITORS

Multi-Chem Group, LLC, H...

1. A composition comprising:at least one compound having the structural formula:

wherein each of R1 and R2 is a C1 to C50 hydrocarbon chain;
wherein each of R3 and R4 is independently selected from the group consisting of: hydrogen and a C1 to C10 hydrocarbon chain; and
wherein X is an anion selected from the group consisting of a bromide, a carboxylate, an organic sulfonate, a hydroxide, and any combination thereof; and
at least one solvent selected from the group consisting of: toluene, xylene, methanol, isopropyl alcohol, glycol, and any combination thereof.

US Pat. No. 10,364,376

ADHESIVE COMPOSITION

TIENSE SUIKERRAFFINADERIJ...

1. A starch-based adhesive composition, wherein the starch comprises a modified starch having a weight-averaged molecular weight of at least 4×106 g/mol, and wherein the amount of the proteins in the adhesive composition is at most 15 wt. % based on dry matter, wherein the starch comprises at least one starch compound having a solubility in distilled water of at least 70%, when measured at 10 wt. % dry matter and at room temperature, said adhesive composition having a tan ? at 10 Hz and 20° C. of at least 1.40.

US Pat. No. 10,364,375

ARTICLE WITH SELF-BONDING FULLY CURED ELASTOMER

Gates Corporation, Denve...

1. A composite article comprising at least one structural member and a substantially fully-cured elastomer member self-bonded to said structural member; said elastomer member comprising the substantially fully-cured reaction product of:at least one elastomeric polymer component, and
at least one curative component at a cure temperature, and further comprising
at least one adhesion promoter having an activation temperature above said cure temperature and which upon activation resulted in said self-bonding between said structural member and said fully-cured elastomer member;
wherein said reaction product comprises 3 to 50 parts by weight of said adhesion promoter based on 100 parts by weight of said elastomeric polymer component.

US Pat. No. 10,364,374

DRY APPLY PROTECTIVE METHODS

ZAGG Intellectual Propert...

1. A method for protecting a surface of a substrate, comprising:grasping a protruding feature of a backing of a system for protecting a surface of a substrate;
grasping a protruding feature of an application tape of the system for protecting a surface of a substrate;
separating the protruding feature of the backing from the protruding feature of the application tape; and
peeling the backing from a protective film of the system for protecting a surface of a substrate to expose an adhesive on an adherent surface of the protective film.

US Pat. No. 10,364,373

ELEVATED TEMPERATURE CMP COMPOSITIONS AND METHODS FOR USE THEREOF

FUJIFILM ELECTRONIC MATER...

1. A CMP composition, consisting of:an abrasive;
an oxidizer;
a complexing agent, wherein the complexing agent is selected from the group consisting of amino acids, carboxylic acids, polyamines, ammonia based compounds, quaternary ammonium compounds, inorganic acids, and any combinations thereof;
a corrosion inhibitor;
at least one reaction rate optimizing compound, wherein the reaction rate optimizing compound is at least one selected from the group consisting of potassium sulfates, potassium nitrates, ammonium sulfates, ammonium nitrates, polymeric solvents, alcohols, thiols, phosphates, sulfates, stannates, EDTA, sulfuric acid, salts of sulfuric acid, phosphoric acid, salts of phosphoric acid, nitric acid, salts of nitric acid, hydrochloric acid, salts of hydrochloric acid, amines, KOH, ammonia, and any combinations thereof; and
water,
wherein the concentration of the reaction rate optimizing compound in the composition is from about 10 to about 10000 ppm;
wherein the reaction rate optimizing compound is selected so that the composition exhibits a removal rate variation of less than about 10% over a wafer surface at a temperature range of about 40 degrees Celsius to about 65 degrees Celsius, and
wherein the composition has a pH value that varies less than 0.3 units between about 45 degrees Celsius and about 65 degrees Celsius.

US Pat. No. 10,364,372

COMPOSITION AND METHOD OF PRODUCING SILICEOUS FILM

TOKYO OHKA KOGYO CO., LTD...

1. A composition comprising:a polysilazane (A); and
an imidazole group-containing compound (B) represented by Formula (B):
wherein Ar is an optionally substituted aromatic group; Rb1 is a hydrogen atom, a halogen atom, a hydroxyl group, a mercapto group, a sulfide group, a silyl group, a silanol group, a nitro group, a nitroso group, a sulfino group, a sulfo group, a sulfonate group, a phosphino group, a phosphinyl group, a phosphono group, a phosphonate group, or an organic group; Y is an imidazole ring represented by Formula (B-y) or a hydrogen atom; Z is an imidazole ring represented by Formula (B-y) or a group represented by —ORb3; Y or Z is the imidazole ring; and is a single bond when Y is the imidazole ring and is a carbon-carbon double bond when Z is the imidazole ring, and Rb3 is a hydrogen atom or an organic group,
wherein the symbol * represents a bond that binds to a carbon atom adjacent to Y or Z in Formula (B); Rb2s are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a mercapto group, a sulfide group, a silyl group, a silanol group, a nitro group, a nitroso group, a sulfonate group, a phosphino group, a phosphinyl group, a phosphonate group, or an organic group.

US Pat. No. 10,364,371

ANTIREFLECTION FILM, OPTICAL MEMBER, AND METHOD OF PRODUCING OPTICAL MEMBER

Canon Kabushiki Kaisha, ...

1. An antireflection film comprising a layer including particles, a binder and a void,wherein at least a part of a surface formed by the particles and the binder and facing to the void is covered with a fluorine compound and the fluorine compound is discontinuously disposed on the surface.

US Pat. No. 10,364,370

COATING COMPOSITION AND COATING FILM FORMED FROM THE SAME

NIPPON PAINT MARINE COATI...

1. A coating composition comprising a silicon atom-containing resin and a defoaming agent,wherein
the silicon atom-containing resin includes a constituent unit (A) derived from a monomer (a) having at least one kind of silicon atom-containing group selected from the group consisting of a group represented by a formula (I) below, a group represented by a formula (II) below, a group represented by a formula (III) below, and a group represented by a formula (IV) below,
the monomer (a) has a molecular weight of greater than or equal to 400 and less than or equal to 2500, and
a content of the defoaming agent is greater than or equal to 0.7 parts by mass and less than or equal to 24 parts by mass with respect to 100 parts by mass of the silicon atom-containing resin:

[wherein in the formula (I), a and b each independently represent an integer of 2 to 5, m represents an integer of 0 to 50, and n represents an integer of 3 to 80; and R1 to R5 each independently represent an alkyl group, an alkoxy group, a phenyl group, a substituted phenyl group, a phenoxy group, or a substituted phenoxy group];

wherein in the formula (II), c and d each independently represent an integer of 2 to 5, and p represents an integer of 0 to 50; R6, R7, and R8 each independently represent an alkyl group, Ra, or Rb;
Ra is

wherein x represents an integer of 0 to 20; and R23 to R27 are the same or different and each represent an alkyl group; and
Rb is

wherein y represents an integer of 1 to 20; and R28 and R29 are the same or different and each represent an alkyl group;

wherein in the formula (III), e, f, g, and h each independently represent an integer of 2 to 5, q and s each independently represent an integer of 0 to 50, and r represents an integer of 3 to 80; and R9 to R12 each independently represent an alkyl group, an alkoxy group, a phenyl group, a substituted phenyl group, a phenoxy group, or a substituted phenoxy group; and

wherein in the formula (IV), i, j, k, and l each independently represent an integer of 2 to 5, t and u each independently represent an integer of 0 to 50, and v and w each independently represent an integer of 0 to 20; and R13 to R22 are the same or different and each represent an alkyl group.

US Pat. No. 10,364,368

ARTICLES INCLUDING HIGH MELT FLOW INDEX RESINS

Hanwha Azdel, Inc., Fore...

1. A method comprising:adding reinforcing fibers and a polyolefin polymer resin to an agitated liquid-containing foam to form a dispersed mixture of the polyolefin polymer resin and reinforcing fibers, wherein the polyolefin polymer resin comprises a melt flow index greater than 100 g/10 min. as measured by ASTM D1238, condition L and wherein the polyolefin polymer resin is present in the dispersed mixture from 20% to 70% by weight and the reinforcing fibers are present from 30% to 70% by weight in the dispersed mixture, wherein the reinforcing fibers comprise a diameter from 5 microns to 22 microns and length from 5 mm to 75 mm;
depositing the dispersed mixture of reinforcing fibers and polyolefin polymer resin onto a forming support element comprising a mesh;
evacuating the liquid from the mesh to form a web;
heating the web above the softening temperature of the polyolefin polymer resin; and
compressing the web using a first set of heated nip rollers to a predetermined thickness to form a composite material to provide an open cell structure within the composite material, wherein about 40% to about 100% of the open cell structures are open and allow the flow of air and gases through the composite material;
passing the compressed web through a second set of heated nip rollers, wherein a temperature provided by the second set of heated nip rollers is lower than a temperature provided by the first set of heated nip rollers;
adding a first surface layer to a first surface of the composite material, wherein the first surface layer comprises one or more of a fabric, a film and a scrim that is continuous from one side of the compressed web to the other side of the compressed web;
adding a second surface layer to a second surface of the composite material; and
passing the composite material with the added first surface layer and the added second surface layer through a pair of nip rollers to provide a composite article, wherein the composite article comprises 5% to 95% voids distributed uniformly through the thickness of the web of the composite article.

US Pat. No. 10,364,366

WATER-BASED INK FOR INK-JET RECORDING AND INK CARTRIDGE

Brother Kogyo Kabushiki K...

1. A water-based ink for ink-jet recording comprising:water;
at least one of quinacridone and a derivative thereof;
a pigment-dispersing resin; and
a dye represented by the following formula (1):
wherein in the formula (1),“n” is 0, 1 or 2;
each of R1, R2 and R3 is one selected from the group consisting of: a substituted or non-substituted alkyl group, a substituted or non-substituted alkoxy group, a halogen atom, a hydrogen atom, a hydroxyl group, a substituted or non-substituted carbamoyl group, a substituted or non-substituted sulfamoyl group, a substituted or non-substituted amino group, a nitro group, sulfonate group, a substituted or non-substituted alkylsulfonyl group, a substituted or non-substituted arylsulfonyl group, a carboxy group and a carboxylate group;
R1, R2 and R3 are same as one another or different from one another;
each of R4, R5 and R6 is one selected from the group consisting of: a hydrogen atom, a substituted or non-substituted alkyl group, a substituted or non-substituted alkenyl group, a substituted or non-substituted aryl group, a substituted or non-substituted aralkyl group, a substituted or non-substituted alicyclic group, and a substituted or non-substituted heterocyclic group;
R4, R5 and R6 are same as one another or different from one another;
each of three Ms is one selected from the group consisting of: H, Li, Na, K, NH4, NH3CH3, N(CH3)4, NH3C2H5, N(C2H5)4, NH2(C2H4OH)2, NH3(C2H4NH)5, and C2H4NH2; and
the three Ms are same as one another or different from one another.

US Pat. No. 10,364,364

PHOTO CURABLE INK COMPOSITION

Hewlett-Packard Developme...

1. A photo curable ink composition, comprising:a photo-reactive binder;
a water soluble polymeric sensitizer, including:
a functionalized anthrone moiety having a formula (A) of:
wherein:R1, R2, R3, and R4 are each independently selected from the group consisting of a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted allyl group, a substituted or unsubstituted alkene or alkenyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, a halogen atom, —NO2, —O—Rd, —CO—Rd, —CO—O—Rd, —O—CO—Rd, —CO—NRdRe, —NRdRe, —NRd—CO—Re, —NRd—CO—O—Re, —NRd—CO—NReRf, —SRd, —SO—Rd, —SO2—Rd, —SO2—O—Rd, —SO2NRdRe, and a perfluoroalkyl group;
Rd, Re, and Rf are each independently selected from the group consisting of a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted allyl group, a substituted or unsubstituted alkene or alkenyl group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted aralkyl group; and
X is O or NH;
a polyether chain; and
an amide linkage or an ether linkage attaching one end of the polyether chain to the functionalized anthrone moiety;
a water soluble photoinitiator having a formula (I) of:
wherein n is any integer from 1 to 5 and M is a metal with a valence from 1 to 5;a colorant; and
a balance of water.

US Pat. No. 10,364,362

INKS

Sericol Limited, Broadst...

1. A radiation-curable ink comprising:(i) a colorant;
(ii) a cyclohexyl acrylate of the Formula (1):
wherein:each R independently is C1-4-alkyl;
n has a value of 1, 2 or 3; and
Q is H or CH3;
(iii) a monoacrylate which comprises a cyclohexyl and/or cyclopentyl ring;
(iv) 0 to 5 wt % of N-vinyl caprolactam;
(v) cyclic trimethylolpropane formal acrylate;
(vi) a compound having a number average molecular weight of up to 1000 and more than one ethylenically unsaturated group;
(vii) an acrylate oligomer having a number average molecular weight greater than 1000;
(viii) a photoinitiator;
(ix) 2-phenoxyethyl acrylate; and
(x) optionally a passive resin.

US Pat. No. 10,364,360

SURFACE COATING MATERIAL, COATING FILM, AND HYDROPHILIC OIL REPELLENT MEMBER

Mitsubishi Materials Corp...

17. A surface coating material which forms a hydrophilic oil repellent layer on at least a part of the surface of a substrate, comprising:one or more fluorine-based compounds represented by the following formulas (1);
a binder; and
a solvent;

wherein in the above formulas (1), Rf1 and Rf2 each represents a linear or branched perfluoroalkyl group having 1 to 6 carbon atoms, which are the same as or different from each other, and Rf3 represents a linear or branched perfluoroalkylene group having 1 to 6 carbon atoms;
in the above formulas (1), X represents anion type hydrophilicity imparting groups and
the anion type hydrophilicity imparting groups have CO2M1, OP(OH)O2M1, OPO3M12, ?O2PO2M1, or PO(OH)y(OM1)2-y, wherein M1 represents an alkali metal, an alkali earth metal, Mg, Al, or R1R2R3R4N+; R1 to R4 -are each independently a hydrogen atom or a linear or branched alkyl group having 1 to 20 carbon atoms, and preferably having 1 to 10 carbon atoms, and y represents an integer of 0 to 2;
wherein the above-described structure of the terminal shows a case where M1 is monovalent, and in a case where M1 is divalent, two identical anions are bonded to M1, or two different types of anions are bonded to M1.

US Pat. No. 10,364,358

CELLULAR GRAPHENE FILMS

The Regents of the Univer...

1. A reduced graphene oxide film comprising a continuous three-dimensional network of pores having a size of less than 1,000 nm, wherein the film has a density of at least about 0.1 g/cm3.

US Pat. No. 10,364,354

WAX ESTER COMPOSITIONS AND METHODS OF MANUFACTURE

International Flora Techn...

1. A wax ester composition comprising:a product of transesterifying three esters derived from fatty acids and fatty alcohols using one of a chemical catalyst, an enzyme catalyst, a bio-based catalyst and any combination thereof where the ratio of the three esters in the mixture prior to transesterification is one of 65%/23%/12%, 56%/29%/15%, and 36%/34%/30%, of a first ester, second ester, and a third ester, respectively, measured by weight of the mixture;
wherein the three esters are derived from oleic acid and oleyl alcohol, stearic acid and stearyl alcohol, and behenic acid and behenyl alcohol.

US Pat. No. 10,364,352

HIGH TEMPERATURE MELT PROCESSABLE SEMI-CRYSTALLINE POLY(ARYL ETHER KETONE) CONTAINING A (4-HYDROXYPHENYL)PHTHALAZIN-1(2H)-ONE COMONOMER UNIT

Polymics, LTD, State Col...

1. An article of manufacture, comprising a polymer composition, said polymer composition comprising a melt processable, semicrystalline aromatic polyetherketone polymer according to formula (I):
wherein Cp is a phthalazinone unit of formula (II);

Q is a biphenol unit of formula (III);

Z is an aromatic ketone unit of formula (VI);

wherein x is a value of at least 1,
wherein y is a value of at least 1,
wherein x and y are such that the molar ratio of Q to Cp is between about 30/70 and 90/10, and
wherein the melt processable semicrystalline aromatic polyetherketone polymer has an enthalpy of melting endotherm of between about 5.0 J/g and 26.0 J/g.

US Pat. No. 10,364,349

ASSEMBLIES CONTAINING POLYETHERKETONEKETONE TIE LAYERS

Arkema Inc., King of Pru...

1. A multilayer assembly comprising a first substrate, a second substrate and an adhesive, wherein a discontinuous adhesive layer consisting of amorphous polyetherketoneketone is positioned between and directly in contact with said first substrate and said second substrate, and wherein the amorphous polyetherketoneketone consists of repeating units represented by formulas I and II:-A-C(?)—B—C(?O)—  I
-A-C(?O)-D-C(?O)—  II
wherein A is a p,p?-Ph-O-Ph- group, Ph is a phenylene radical, B is p-phenylene, and D is m-phenylene and the isomer ratio of formula I:formula II (T:I) is 60:40 so as to provide amorphous polyetherketoneketone; wherein a contact surface of said first substrate is the same as or different from a contact surface of said second substrate and each of the contact surface of said first substrate and the contact surface of said second substrate is selected from the group consisting of glass, and prepreg tape.

US Pat. No. 10,364,347

EPOXY RESIN COMPOSITION, PREPREG, FIBER-REINFORCED COMPOSITE MATERIAL, AND HOUSING FOR ELECTRICAL OR ELECTRONIC EQUIPMENT

Mitsubishi Chemical Corpo...

1. An epoxy-resin composition, comprising:a component (A), which is a phosphorus compound that has a phosphorus atom content of at least 1.0 mass % but no more than 8.0 mass %;
wherein the component (A) is a phosphorus modified epoxy resin comprising a compound (b) represented by formula (b):

n represents an integral number of zero or greater;
X represents a group shown in formulas (I), (II) or (III):

at least one of the X groups is formula (III),
(n+2) X groups may be the same or different, with the proviso that at least one of the (n+2) X groups is a group of formula (I) or (II); and
Y represents a (—H) or (—CH3) group, such that (n+2) Y groups may be the same or different;
a component (B) is at least one selected from the group consisting of a trisphenolmethane epoxy resin, an aminophenol epoxy resin, a diaminodiphenylmethane epoxy resin, a novolac epoxy resin and a modified epoxy resin thereof;
a component (C), which is dicyandiamide; and
a component (D), which is 1,1?(4-methyl-1,3-phenylene)bis(3,3-dimethylurea) wherein:
the amount of urea groups derived from the component (D) is at least 0.40 times to 1.85 times or lower than a molar amount of phosphorus atoms derived from the component (A); and
the amount of the component (A) to 100 parts by mass of the epoxy-resin composition excluding the component (A) is 10 parts by mass to 80 parts by mass;
the amount of the component (B) is 58 parts by mass to 100 parts by mass, relative to 100 parts by mass of epoxy resin contained in the epoxy resin composition excluding the component (A);
the ratio of the active hydrogen equivalent of component (C) is 0.5 to 0.8 relative to the epoxy equivalent of the epoxy-resin composition excluding component (C), and
the molar amount of the urea group from the component (D) is 0.03 to 0.25 times the molar amount of the epoxy groups in the epoxy resin composition.

US Pat. No. 10,364,341

METHOD AND APPARATUS FOR 3D PRINTING OF NANO-FILLER/POLYMER COMPOSITES

Arevo, Inc., Milpitas, C...

1. A method for printing an object via additive manufacturing, the process comprising:depositing a first layer, the first layer comprising droplets of a thermo-polymer ink, wherein the thermo-polymer ink comprises thermo-plastic resin particles ultrasonically dispersed in a first suspension medium;
depositing, a second layer on at least a portion of the first layer, wherein the second layer comprises droplets of a nano-filler ink, wherein the nano-filler ink comprises a first nano-filler ultrasonically dispersed in a second suspension medium;
depositing a third layer on at least a portion of the second layer, wherein the third layer comprises droplets of the thermo-polymer ink comprising thermo-plastic resin particles ultrasonically dispersed in the first suspension medium; and
exposing the first, second and third layers to microwave radiation.

US Pat. No. 10,364,340

USE OF ORGANIC OXYIMIDES AS RADICAL GENERATORS IN PLASTICS, METHOD FOR GENERATING RADICALS IN PLASTICS AND USE OF SAID METHOD

1. A method of incorporating a radical generator into a plastic material comprising incorporating into said plastic material an organic oxyimide having the structural element of formula I
wherein the radical generator is activated thermally or by irradiation,
wherein the activation is accomplished during shaping of the plastic material or shaping of a moulding compound comprising the plastic material,
wherein the thermal activation is accomplished at a temperature of 240° C. or more,
said method resulting in a modification of the plastic material, wherein the modification is increasing the molecular weight of the plastic material, branching or crosslinking of the plastic material, molecular weight decrease of the plastic material, influencing a molecular weight distribution of the plastic material, and/or grafting of an unsaturated monomer onto the plastic material.

US Pat. No. 10,364,339

POLYAMIDE RESIN COMPOSITION AND MOLDED ARTICLE PRODUCED THEREFROM

KURARAY CO., LTD., Kuras...

1. A polyamide resin composition comprising:100 parts by mass of (A) a polyamide having a melting point of 280 to 330° C.;
0.5 to 80 parts by mass of (B) aluminum diethylphosphinate;
0.2 to 2 parts by mass of (C) at least one phosphorous acid ester represented by formula (6) or (7); and
(E) at least one reinforcing material, wherein a mass ratio of the at least one phosphinic acid salt (B) to the at least one phosphorous acid ester (C) ((B)/(C)) is in a range of from 10 to 100, and an average particle diameter of the phosphinic acid salt (B) is 0.1 to 100 ?m:

wherein the polyamide resin composition does not comprise a metallic soap-based lubricant.

US Pat. No. 10,364,338

THERMAL EXPANDABILITY ADJUSTER, USE AS THERMAL EXPANDABILITY ADJUSTER, THERMOSET RESIN COMPOSITION, INSULATING MATERIAL, SEALING MATERIAL AND CONDUCTIVE PASTE EACH CONTAINING THERMOSET RESIN COMPOSITION, CURED PRODUCTS, PREPREG AND MEMBER OBTAINED BY CURI

AIR WATER INC., Hokkaido...

1. A thermoset resin composition, comprising:a glycoluril derivative compound represented by formula (1)

at least one bismaleimide compound;
at least one phenol resin; and
at least one epoxy resin other than the glycoluril derivative compound,
wherein the glycoluril derivative compound represented by the formula (1) is a thermal expansion rate adjuster.

US Pat. No. 10,364,337

INHIBITION OF AMINE OXIDATION

HUNTSMAN Petrochemical LL...

1. A method of forming an inhibitor-treated amine comprising combining:(i) an oxidation-sensitive amine selected from one or more of a tertiary amine catalyst, a polyetheramine, an ethyleneamine, a surfactant amine, and an amine selected from 2-(2-aminoethoxy)ethanol, diethanolamine, N-methyldiethanolamine, and triethanolamine, with
(ii) an amine-oxidation inhibitor, wherein the amine-oxidation inhibitor is a free-radical scavenger selected from one or more of allupurinol, propyl thiouracil, glutamine, diaminobenzylamine, and nicotinamide,
wherein the amount of amine-oxidation inhibitor added to the oxidation-sensitive amine is in an amount ranging from 5 ppm to 5000 ppm.

US Pat. No. 10,364,334

CONTINUOUS PRODUCTION EQUIPMENT AND PREPARATION METHOD FOR GRAPHENE COMPOSITE MATERIAL

CHANGZHOU HIGHBERY NEW NA...

1. Continuous production equipment for graphene composite material, comprising:a raw material preparation device;
a reaction device, a material discharge end of the raw material preparation device being connected to the reaction device; and
an extraction device configured to extract and purify crude composite material obtained from the reaction device, a material feed end of the extraction device being connected to the material discharge end of the reaction device, and a material discharge end of the extraction device being configured to convey polyamide monomer extract obtained by extraction to a liquid conveying pipe of the raw material preparation device;
wherein the raw material preparation device comprises a raw material melting kettle configured to melt polyamide monomer and mix the molten polyamide monomer with graphene, and the raw material melting kettle is provided with a high-shear emulsifying machine and an ultrasonic disperser.

US Pat. No. 10,364,264

PROLIFERATIVE DISEASE TREATMENT METHODS WITH PHOSPHAPLATIN COMPLEXES

Ohio University, Athens,...

1. A method of treating a proliferative disease, comprising:administering to a subject in need thereof a therapeutically effective amount of a composition comprising a phosphaplatin complex, wherein the phosphaplatin complex is enantiopure (1R,2R)-pyrodach-2 having formula (I):

or a pharmaceutically acceptable salt or solvate thereof; and

wherein the proliferative disease is selected from the group consisting of ovarian cancer, lung cancer, prostate cancer, head-and-neck cancer, pancreatic cancer, and breast cancer.

US Pat. No. 10,364,263

CYCLIC PHOSPHATES AND CYCLIC PHOSPHORAMIDATES FOR THE TREATMENT OF NEUROLOGIC DISORDERS

Retrophin, Inc., San Die...

1. A compound having the following structure (I):or a pharmaceutically acceptable salt thereof, wherein:E is O;
D is absent, aryl, C1-C3 alkylene, C1-C3 alkylene substituted with R3, C(O)O(alkylene) or C(O)O(alkylene) substituted with R3;
B is absent, C1-C3 alkylene, C3-C6 cycloalkylene, (C1-C3 alkylene)NR2, C(O)NR2(alkylene), aryl, heteroaryl or heterocyclyl, wherein each of said C1-C3 alkylene, C3-C6 cycloalkylene, (C1-C3 alkylene)NR2, C(O)NR2(alkylene), aryl, heteroaryl and heterocyclyl is unsubstituted or substituted with R6 or R8;
A is absent, H, OR5, R5C(O), R5OC(O), R5OC(O)O, R5C(O)O, R5C(O)S, NR2R5C(O), R5C(O)NR2, R5S(O)NR2, R5SO2NR2, NR2R5, CN, C1-C6 alkyl, C3-C6 cycloalkyl, heterocyclyl or aryl, wherein each of said C1-C6 alkyl, C3-C6 cycloalkyl, heterocyclyl and aryl is unsubstituted or substituted with R6;
R1 is H, C1-C6 alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, C3-C6 cycloalkyl, or cycloalkylalkyl, wherein each of said C1-C6 alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, C3-C6 cycloalkyl, and cycloalkylalkyl is unsubstituted or substituted with R6;
R2 is H or C1-C6 alkyl;
R3 is H, C1-C6 alkyl, hydroxy, amino, arylalkyl, heteroarylalkyl or C3-C6 cycloalkyl, wherein each of said C1-C6 alkyl, arylalkyl, heteroarylalkyl and C3-C6 cycloalkyl is unsubstituted or substituted with R4;
R4 is C1-C6 alkyl, C1-C6 alkoxy, hydroxy or amino;
R5 is H, C1-C6 alkyl, C1-C6 alkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, C3-C6 cycloalkyl, cycloalkylalkyl, amino, alkylamino, dialkylamino, aminoalkyl, alkylaminoalkyl or dialkylaminoalkyl, wherein each of said C1-C6 alkyl, C1-C6 alkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, amino, alkylamino, dialkylamino, aminoalkyl, alkylaminoalkyl and dialkylaminoalkyl is unsubstituted or substituted with R6 or R8;
R6 is C1-C6 alkyl, C1-C6 alkoxy, hydroxyl, amino, halo, oxo, CN, NO2, SF5, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, C3-C6 cycloalkyl, C3-C4 spiro-substituted cycloalkyl, cycloalkylalkyl, SO2R7, R7C(O)S, R7C(O), R7C(O)NR2, R7OC(O) or R7OC(O)NR2, wherein each of said C1-C6 alkyl, C1-C6 alkoxy, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, C3-C6 cycloalkyl, C3-C4 spiro-substituted cycloalkyl and cycloalkylalkyl is unsubstituted or substituted with R7;
R7 is H, C1-C6 alkyl, C1-C6 alkoxy, hydroxyl, halo, oxo, CN, NO2, SF5, arylakyl, heteroarylalkyl, amino, alkylamino or dialkylamino; and
R8 is R6OC(O) or R6OC(O)NR2;
or
D is absent, and A, B, and E together form a 6-membered heterocyclic or heteroaryl ring, wherein said heterocyclic or heteroaryl ring is unsubstituted or substituted with R6.

US Pat. No. 10,364,259

ZIRCONIUM, HAFNIUM, TITANIUM PRECURSORS AND DEPOSITION OF GROUP 4 CONTAINING FILMS USING THE SAME

1. A Group 4 transition metal-containing film forming composition comprising a Group 4 transition metal precursor having the formula —(R2N)2-M-C5R4—[C2H4—NR]— referring to the following structure formula:
wherein M is Ti, Zr, or Hf bonded in an ?5 bonding mode to the Cp group and each R is independently a hydrogen or a C1-C4 hydrocarbon group; provided that at least one R on the Cp is C1 to C4.

US Pat. No. 10,364,258

HETEROARYL INHIBITORS OF PDE4

Tetra Discovery Partners,...

1. A method for treating a disease chosen from depression, depression secondary to illness, major depressive disorder, multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, transverse myelitis, amyotrophic lateral sclerosis, and arteriosclerotic dementia in a subject in need thereof, comprising the administration to the subject a compound of structural Formula XI:and/or a salt thereof, wherein:Y is C(R2)2;
X is chosen from CH and N;
n is an integer chosen from 0, 1 or 2;
each R2 is independently chosen from hydrogen and lower alkyl;
R3 is chosen from methyl, ethyl, trifluoromethyl, and cyclopropyl;
R4 is chosen from hydrogen and ethyl;
R5 is either benzoxaborole, or is chosen from phenyl and pyridinyl, either of which is para-substituted with a substituent of the form R8—R9—(R10)a(R10)b, and is optionally substituted with a substituent R13;
R8 is chosen from a bond and lower alkyl;
R9 is chosen from halogen, lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxy, lower haloalkoxy, cyano, —C(O)N—, S(O)2—, B(OH)2, 5-6 membered monocyclic heterocycloalkyl, and 5-6 membered monocyclic heteroaryl;
(R10)a and (R10)b are each independently chosen from null, hydrogen, halogen, trifluoromethyl, trifluoromethoxy, hydroxyl, lower hydroxyalkyl, cyano, oxo, lower alkyl, C(O)OH, and C(O)O lower alkyl;
R13 is chosen from halogen, hydroxy, lower alkyl, trifluoromethyl, lower alkoxy, trifluoromethoxy, NH2, and cyano;
R6 is chosen from 3-chlorophenyl, 5-chloro-2-thienyl, cyclopentyl optionally substituted with one or two R14, and cyclopentoxy optionally substituted with one or two R14; and
each R14 is independently chosen from halogen, hydroxy, lower alkyl, trifluoromethyl, lower alkoxy, trifluoromethoxy, NH2, and cyano.

US Pat. No. 10,364,257

APPARATUS AND CONTINUOUS FLOW PROCESS FOR PRODUCTION OF BORONIC ACID DERIVATIVES

REMPEX PHARMACEUTICALS, I...

1. A process for production of a compound of Formula (Ia) or (Ib),
wherein:
Q is —(CH2)n—;
M is —CH2— or —CH?CH—;
n is 1 or 2;
R1 is a carboxyl protecting group;
R2 is a hydroxyl protecting group; or
R1 and R2 together with the atoms to which they are attached form a heterocyclic ring optionally substituted with C1-4 alkyl;
each R3 is independently selected from hydrogen, —OH, halogen, —CF3, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 heteroalkyl, C3-C7 carbocyclyl, 5-10 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl, cyano, C1-C6 alkoxy(C1-C6)alkyl, C6-10 aryloxy, sulfhydryl (mercapto), and —(CH2)m—Y?—(CH2)pM?;
m and p are independently 0 to 3;
Y? is selected from the group consisting of —S—, —S(O)—, —S(O)2—, —O—, —CR4aR5a—, and —NR1a—;
M? is selected from the group consisting of C(O)NR1aR2a; —C(O)NR1aOR3a; —NR1aC(O)R4a; —NR1aC(O)NR2aR1b; —NR1aC(O)OR3a; NR1S(O)2R3a; —NR1aS(O)2NR2aR1b; —C(?NR1a)R4a; —C(?NR1a)NR2aR1b; —NR1aCR4a(?NR2a); —NR1aC(?NR2a)NR1bR2b; C1-4 alkyl optionally substituted with 0-2 substituents selected from the group consisting of —OR3a, —NR1aR2a, halogen, —C(O)NR1aR2a, and —NR1aC(O)R4a; C3-10 cycloalkyl optionally substituted with 0-2 substituents selected from the group consisting of C1-4 alkyl, —OR3a, —NR1aR2a, halogen, —C(O)NR1aR2a, and —NR1aC(O)R4a; C6-10 aryl optionally substituted with 0-2 substituents selected from the group consisting of C1-4 alkyl, —OR3a, —NR1aR2a, halogen, —C(O)NR1aR2a, and —NR1aC(O)R4a; 5 to 10 membered heteroaryl optionally substituted with 0-2 substituents selected from the group consisting of C1-4 alkyl, —OR3a, —NR1aR2a; halogen, —C(O)NR1aR2a; and —NR1aC(O)R4a; and 4 to 10 membered heterocyclyl optionally substituted with 0-2 substituents selected from the group consisting of C1-4 alkyl, —OR3a, —NR1aR2a, halogen, —C(O)NR1aR2a, and —NR1aC(O)R4a;
each R1a, R2a, R1b and R2b are independently selected from the group consisting of —H, optionally substituted C1-10alkyl, optionally substituted C2-10alkenyl, optionally substituted C2-10alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted 3-8 membered heterocyclyl, optionally substituted C6-10aryl, and optionally substituted 5-10 membered heteroaryl;
R3a is hydrogen, optionally substituted C1-10alkyl, optionally substituted C1-10alkyl-COOH, optionally substituted C2-10alkenyl, optionally substituted C2-10alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted 3-8 membered heterocyclyl, optionally substituted C6-10aryl, and optionally substituted 5-10 membered heteroaryl; and
each R4a and R5a is independently selected from the group consisting of —H, —OH, —optionally substituted alkoxyl, optionally substituted C1-10alkyl, optionally substituted C2-10alkenyl, optionally substituted C2-10alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted 3-8 membered heterocyclyl, optionally substituted C6-10aryl, and optionally substituted 5-10 membered heteroaryl;
the process comprising:
providing a first continuous flow of alkyl lithium;
providing a continuous flow of dichloromethane;
combining the first continuous flow of alkyl lithium and the continuous flow of dichloromethane at an input of a first continuous flow conduit to yield a continuous flow of a first reaction intermediate at an output of the first continuous flow conduit;
providing a continuous flow of a compound of Formula (IIa) or (IIb);

combining the continuous flow of the first reaction intermediate and the continuous flow of the compound of Formula (IIa) or (IIb) at an input of the a second continuous flow conduit to yield a second reaction intermediate at an output of the second continuous flow conduit;
collecting the second reaction intermediate at the output of the second continuous flow conduit; and treating the collected second reaction intermediate with a Lewis acid to yield the compound of Formula (Ia) or (Ib).

US Pat. No. 10,364,256

BIARYL PYRAZOLES AS NRF2 REGULATORS

GlaxoSmithKline Intellect...

1. A compound of Formula (I):
wherein:
R is hydrogen or —C1-5alkyl, wherein —C1-5alkyl is unsubstituted or substituted by one or two substituents independently selected from —OH, —OC(O)—C1-5alkyl, —OC(O)-phenyl, —OC(O)—O—C1-5alkyl,

R1 is —CF3, —C3-7cycloalkyl, or —C4-7heterocycloalkyl, wherein the —C3-7cycloalkyl, or —C4-7heterocycloalkyl is unsubstituted or substituted by one or two substituents independently selected from —C1-3alkyl, phenyl, triazolyl, pyridyl, pyridazinyl, imidazolyl, pyrazolyl, isoxazolyl, halo, —NR9—C(O)—R10 and —C(O)R10, and wherein each of the phenyl, triazolyl, pyridyl, pyridazinyl, imidazolyl, pyrazolyl and isoxazolyl is unsubstituted or substituted by one or two substituents independently selected from halo, phenyl, and —C1-7alkyl optionally substituted with phenyl, —N(CH3)2, —CF3, —OH, —C3-7cycloalkyl optionally substituted with C1-3alkyl, and
—C3-7heterocylcoalkyl optionally substituted with —C1-3alkyl or —C(O)—C1-4alkyl;
or R1 is —C2-3alkyl-R11;
R2a is hydrogen, halo, or —C1-3alkyl;
R2 is hydrogen, halo, —CN, —O—C1-3alkyl, —OH, or —C1-3alkyl;
G is CH or N;
A is

R3 is —(CH2)n—C(O)NR5R6, —(CH2)n—C(R14)(R15)—NR5R6, —(CH2)n—S(O)NR5R6

or R3 is —O—C1-6alkyl, —C1-6 alkyl, —C4-7heterocycloalkyl, —O—C4-7 heterocycloalkyl, —N—R12R13, —C3-7 cycloalkyl, —O—C3-7 cycloalkyl, —S—C1-3 alkyl, —S—C4-7heterocycloalkyl, S—C3-7 cycloalkyl, —S(O)—C1-3alkyl, —S(O)—C4-7 heterocycloalkyl, —S(O)—C3-7 cycloalkyl, —S(O)2—C1-3alkyl, —S(O)2—C4-7 heterocycloalkyl, or —S(O)2—C3-7 cycloalkyl, wherein each of —O—C1-6alkyl, —C1-6 alkyl, —C4-7heterocycloalkyl, —O—C4-7 heterocycloalkyl, —C3-7 cycloalkyl, —O—C3-7 cycloalkyl, —S—C1-3alkyl, —S—C4-7heterocycloalkyl, S—C3-7 cycloalkyl, —S(O)—C1-3alkyl, —S(O)—C4-7 heterocycloalkyl, —S(O)—C3-7 cycloalkyl, —S(O)2—C1-3alkyl, —S(O)2—C4-7 heterocycloalkyl, or —S(O)2—C3-7 cycloalkyl, is unsubstituted or substituted by one or two substituents independently selected from —C1-7 alkyl, —C3-7 cycloalkyl, —OH, ?O, —O—C1-5 alkyl, CF3, —C4-7heterocycloalkyl, phenyl, pyridyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, and triazolyl, and wherein each of —C1-7 alkyl, —C3-7 cycloalkyl, —O—C1-3 alkyl, —C4-7 heterocycloalkyl, phenyl, pyridyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, or triazolyl is unsubstituted or further substituted by one or more substituents independently selected from —C1-5 alkyl, —CF3, —OC1-3alkyl, phenyl, —C(O)—O—C1-5alkyl and halo;
Each R4 is independently hydrogen, halo or —C1-3alkyl,
R5 and R6 are independently H, —C1-6 alkyl, —C3-7 cycloalkyl or —C4-7 heterocycloalkyl, wherein each of —C1-6 alkyl, —C3-7 cycloalkyl or —C4-7 heterocycloalkyl is unsubstituted or substituted by one or more substituents selected from F, —CH—F2, —CF3, —(CH2)n—O—(CH2)m—CH3, and —C3-7cycloalkyl;
or R5 and R6 together with the nitrogen atom to which they are attached form a 5-8-membered ring, an 8-11-membered bicyclic ring or a 9-10-membered bridged bicyclic ring, wherein each 5-8-membered ring, 8-11-membered bicyclic ring, or 9-10-membered bridged bicyclic ring optionally includes one —S(O)2, one or more oxygen ring atoms or one or more nitrogen ring atoms, and wherein each 5-8-membered ring, 8-11-membered bicyclic ring, or 9-10-membered bridged bicyclic ring is unsubstituted or substituted by one, two or three substituents independently selected from —C1-5 alkyl, —C3-7cycloalkyl, —C4-7heterocycloalkyl, halogen, —CHF2, —CF3, and —(CH2)n—O—(CH2)m—CH3;
or R5 and R6 together with the nitrogen atom to which they are attached form 4-azaspiro[2.5]octane, 7-azaspiro[4.5]decane, 2-oxa-8-azaspiro[5.5]undecane, 6-oxa-9-azaspiro[4.5]decane, 2-oxa-8-azaspiro[5.5]undecane, 1-azaspiro[4.5]decane, 2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine or 2,3,4,5-tetrahydro-1H-benzo[c]azepine;
R7 and R8 are independently H, —C1-6 alkyl, —C3-7 cycloalkyl or —C4-7 heterocycloalkyl, wherein each of —C1-6 alkyl, —C3-7 cycloalkyl or —C4-7 heterocycloalkyl is unsubstituted or substituted by one or two substituents independently selected from F, —CHF2, —CF3, and —(CH2)n—O—(CH2)m—CH3;
or R7 and R8 together with the carbon atoms to which they are attached form a 5-8-membered ring, which optionally includes one or more oxygen or nitrogen atoms as ring atoms, and wherein the 5-8-membered ring is unsubstituted or substituted by one or two substituents independently selected from —C1-5 alkyl, —C3-7 cycloalkyl, —C4-7 heterocycloalkyl, F, —CHF2, —CF3, ?O, and —(CH2)n—O—(CH2)m—CH3;
R9 is H or —C1-3alkyl;
R10 is —C1-3alkyl;
R11 is aryl, triazolyl, pyridyl, pyridazinyl, imidazolyl, or pyrazolyl, wherein each of aryl, triazolyl, pyridyl, pyridazinyl, imidazolyl, or pyrazolyl is unsubstituted or substituted by one or two substituents independently selected from —C1-3alkyl and halo;
R12 and R13 are independently C4-7 heterocycloalkyl, —C1-3 alkyl or —C3-7 cycloalkyl, wherein each of the —C4-7 heterocycloalkyl, —C1-3 alkyl or —C3-7 cycloalkyl is unsubstituted or substituted by one or two substituents independently selected from —C1-7alkyl, —C3-7cycloalkyl, —OH, ?O, —O—C1-5alkyl, —C4-7heterocycloalkyl, phenyl, pyridyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, and triazolyl, and wherein each of the —C1-7alkyl, —C3-7cycloalkyl, —O—C1-5alkyl, —C4-7heterocycloalkyl, phenyl, pyridyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, or triazolyl is further optionally substituted by one or more substituents independently selected from —C1-5alkyl and halo;
R14 is hydrogen or —C1-3alkyl;
R15 is hydrogen or —C1-3alkyl;
Each X is CR4 or N provided only one X is N;
Each n is independently 0 or 1;
Each m is independently 0 or 1;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,364,255

HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS

Boehringer Ingleheim Inte...

1. A compound of the formula (I),
wherein
A is a group of formula A.1 or A.2:

wherein each R1, R2, R3, R4, R5 and R6 is independently selected from the group consisting of H, C1-4-alkyl, C1-4-alkyl substituted with a hydroxyl or halogen group, phenyl and a 5-6 membered heteroaryl, or
R1 and R2, R3 and R4, or R5 and R6 together form a 3-4 membered carbocycle, and
wherein
B is selected from the group consisting of formulas B.1, B.2 and B.3:

wherein
R7 is H, C1-3-alkyl, halogen, C1-3-alkoxy, 5-6 membered heteroaryl, or
R7 is selected from the group consisting of R7.a, R7.b and R7.c

wherein
R8 is selected from the group consisting of C1-6-alkyl, C3-6-cycloalkyl, and 3-14 membered heterocyclyl and
X is CH2 or O;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,364,253

SALINOMYCIN DERIVATIVES AND THERAPEUTIC USES THEREOF

Channel Therapeutics, Inc...

1. A compound having the structure of Formula (I)
or a pharmaceutically acceptable salt thereof, wherein:
X is

R is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C3-C7 carbocyclyl, 5-10 membered heterocyclyl, C6-10 aryl, and 5-10 membered heteroaryl;
n is an integer from 0 to 6;
Y is selected from the group consisting of —NR1C(O), —C(O)NR1—, —OC(O)—, C(O)O—, —CR1(COOR2)—CR3?CR4—, and —CR1?CR2—;
m is an integer from 0 to 6;
Z is —CR1?CR2—, —CR1(COOR2)—CR3?CR4, or absent;
G is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C3-C7 carbocyclyl, 5-10 membered heterocyclyl, C6-10 aryl, and 5-10 membered heteroaryl, each optionally substituted with 1-3 substituents selected from the group consisting of halogen, C1-4 alkyl, halogenC1-4 alkyl, —OR1, —CN, —NO2, —NR1R2, —C(O)NR1R2, and —NR1C(O)R5; and
each of R1, R2, R3, R4, and R5 are independently selected from —H, —CN, —NO2, —NH2, —OH, C1-4 alkyl, halogenC1-4 alkyl, C2-10alkenyl, C2-10alkynyl, C3-7 cycloalkyl, 3-8 membered heterocyclyl, C6-10aryl, and 5-10 membered heteroaryl.

US Pat. No. 10,364,252

OXABICYCLOHEPTANE PRODRUGS

Lixte Biotechnology, Inc....

1. A method for in vivo delivery of endothall to a target cell in a subject afflicted with cancer, the method comprising administering to the subject a compound having the structure:or a pharmaceutically acceptable salt or ester of the compound, whereinX is

R17 is H, alkyl, hydroxyalkyl, alkenyl, alkenyl, alkynyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, C(O)O-t-Bu or —CH2CN;
R18 is H or alkyl;
R19 is (C1-C4 alkyl)-O(CO)R4, (C1-C4 alkyl)-O(CO)OR4, (C1-C4 alkyl)-OP(O)(OR4)2, (C1-C4 alkyl)-OP(O)(O(C1-C4 alkyl)-O(CO)OR4)2, (C1-C4 alkyl)-OP(O)(O(C1-C4 alkyl)-O(CO)R4)2, (C1-C4 alkyl)NR4R5, (C1-C4 alkyl)NC(O)R4, (C1-C4 alkyl)C(O)OR4, (C1-C4 alkyl)OC(O)aryl(C1-C4 alkyl)P(O)(OR4)2, (C1-C4 alkyl)OC(O)(C2-C4 alkenyl)CO2R4, (C1-C4 alkyl)OC(O)(C1-C4 alkyl)NH2, (C1-C4 alkyl)C(O)NR4R5,

wherein each occurrence of R4 is, independently, H, alkyl, alkenyl, alkynyl, aryl or heteroaryl;
wherein each occurrence of R5 is, independently, H, alkyl, alkenyl, alkynyl, aryl or heteroaryl;
wherein each occurrence of R6 and R7 is, independently, H, alkyl, alkenyl, alkynyl, aryl or heteroaryl;
wherein each occurrence of R8 is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl or heteroaryl; and
Y is OR9 or NR10R11, wherein
R9 is (C1-C4 alkyl)-O(CO)R12, (C1-C4 alkyl)-O(CO)OR12, (C1-C4 alkyl)-OP(O)(OR12)2, (C1-C4 alkyl)-OP(O)(O(C1-C4 alkyl)-O(CO)OR12)2, (C1-C4 alkyl)-OP(O)(O(C1-C4 alkyl)-O(CO)R12)2, (C1-C4 alkyl)NR12R13, (C1-C4 alkyl)NHC(O)R12, (C1-C4 alkyl)C(O)OR12, (C1-C4 alkyl)OC(O)aryl(C1-C4 alkyl)P(O)(OR12)2, (C1-C4 alkyl)OC(O)(C2-C4 alkenyl)CO2R12, (C1-C4 alkyl)OC(O)(C1-C4 alkyl)NH2, (C1-C4 alkyl)C(O)NR12R13,

R10 is H; and
R11 is (C1-C4 alkyl)-O(CO)R12, (C1-C4 alkyl)-O(CO)OR12, (C1-C4 alkyl)-OP(O)(OR12)2, (C1-C4 alkyl)-OP(O)(O(C1-C4 alkyl)-O(CO)OR12)2, (C1-C4 alkyl)-OP(O)(O(C1-C4 alkyl)-O(CO)R12)2, (C1-C4 alkyl)NR12R13, (C1-C4 alkyl)NHC(O)R12, (C1-C4 alkyl)C(O)OR12, (C1-C4 alkyl)OC(O)aryl(C1-C4 alkyl)P(O)(OR12)2, (C1-C4 alkyl)OC(O)(C2-C4 alkenyl)OC(O)(C1-C4 alkyl)NH2, (C1-C4 alkyl)C(O)NR12R13,

wherein each occurrence of R12 is, independently, H, alkyl, alkenyl, alkynyl, aryl or heteroaryl;
wherein each occurrence of R13 is, independently, H, alkyl, alkenyl, alkynyl, aryl or heteroaryl;
wherein each occurrence of R14 and R15 is, independently, H, alkyl, alkenyl, alkynyl, aryl or heteroaryl; and
wherein each occurrence of R16 is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl or heteroaryl,
wherein
when X is
where R17 is CH3, then Y is other than —O(C4 alkyl)-OP(O)(OEt)2 or —NH(C4 alkyl)-OP(O)(OE)2; andwherein the cancer is brain cancer, breast cancer, colon cancer, large cell lung cancer, adenocarcinoma of the lung, small cell lung cancer, stomach cancer, liver cancer, ovary adenocarcinoma, pancreas carcinoma, prostate carcinoma, promylocytic leukemia, chronic myelocytic leukemia, acute lymphocytic leukemia, colorectal cancer, ovarian cancer, lymphoma, non-Hodgkin's lymphoma or Hodgkin's lymphoma cell.

US Pat. No. 10,364,250

BIOACTIVE COMPOUNDS

1. A congener of portimine of the structure:
where: R1 is selected from the group consisting of: H, acyl, alkyl, alkylene, aryl and aralkyl; R2 is selected from the group consisting of: H, acyl, alkyl, alkylene, aryl and aralkyl; M is O, S, N—NH2, N(alkyl)2, N-alkoxy or N(aryl)2; W and X may form a bond, an epoxide, or are independently selected from the group consisting of: H, halogen, OH and O-acyl; Y and Z form a bond, an epoxide, or are independently selected from the group consisting of: H, halogen, OH and O-acyl; and when R1 and R2 are H, then M is not O, or W and X or Y and Z do not form a bond.

US Pat. No. 10,364,249

AZATRIANGULENIUM SALTS AS PET-QUENCHED FLUORESCENT PROBES

Kobenhavns Universitet, ...

1. A fluorescent dye compound of Formula (I)
wherein
X1 denotes NR11, O, S, or C(R11)2, or denotes two individual substituted or unsubstituted C1-C24-alkoxy groups, which each are linked to the two adjacent carbon atoms,
X2 denotes NR12, O, S, or C(R12)2, or denotes two individual substituted or unsubstituted C1-C24-alkoxy groups, which each are linked to the two adjacent carbon atoms,
R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are independently selected from hydrogen, cyano, halogen, hydroxy, nitro, acyl, acylamino, acyloxy, C1-C24-alkyl, C2-C24-alkenyl, C2-C24-alkynyl, aryl, C1-C24-alkoxy, C1-C24-alkylsulfonyl, methylsulfonyl, triflouromethyl, amino, aminocarbonyl, aminothiocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyl, aminosulfonyloxy, aminosulfonylamino, amidino, carboxyl, carboxyl ester, (carboxyl ester)amino, (carboxyl ester)oxy, sulfonyl, sulfonyloxy, thioacyl, thiol, thiocarbonyl, C1-C24-alkylthio, heteroaryl, cycloalkyl, phenyl, hydroxyphenyl, aminophenyl, amino-C1-C24-alkyl, or heterocyclyl selected from a 5- or 6-membered heterocyclyl containing at least one nitrogen or sulphur atom, or two of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 may together form a ring system; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 optionally being substituted once, twice, or three times with R13 substituent(s), or a L-Si(OR14)3 substituent,
R13 is independently selected from hydrogen, cyano, halogen, hydroxy, nitro, acyl, acylamino, acyloxy, C1-C24-alkyl, C2-C24-alkenyl,
C2-C24-alkynyl, aryl, C1-C24-alkoxy, C1-C24-alkylsulfonyl, methylsulfonyl, triflouromethyl, amino, aminocarbonyl, aminothiocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyl, aminosulfonyloxy, aminosulfonylamino, amidino, carboxyl, carboxyl ester, (carboxyl ester)amino, (carboxyl ester)oxy, sulfonyl, sulfonyloxy, thioacyl, thiol, thiocarbonyl, C1-C24-alkylthio, heteroaryl, or a cycloalkyl, or two R13 substituents may together form a ring system,
R14 is independently selected from hydrogen, or straight or branched C1-C6 alkyl, alkenyl, or alkynyl, and
one or more of the substituents R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 or R12 is/are
a quenching group independently selected from phenyl substituted with one to five R13 substituent(s) wherein at least one R13 substituent is hydroxy, or a group selected from indole, benzoefuran, naphthalene, a 5- or 6-membered heterocyclyl or a C1-C6 alkylene heterocyclyl containing at least one of N, NH, O, or S, said group being substituted one, two, or three times with R13 substituent(s), wherein at least one R13 substituent, attached to indole, benzoefuran, naphthalene, the 5- or 6-membered heterocyclyl, or the heterocyclyl moiety of C1-C6 alkylene heterocyclyl is hydroxy, and
optionally together with a counter ion.

US Pat. No. 10,364,248

PROCESSES FOR PREPARING 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

Incyte Corporation, Wilm...

1. A process for preparing a compound of Formula XIa:
wherein the process comprises:
treating a compound of Formula F-1:

with acid in a solvent at reflux temperature, to form the compound of Formula XIa above.

US Pat. No. 10,364,247

PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS

Ruijin Hospital Affiliate...

1. A compound of formula IA:
or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from —N(R)2; and
each R is independently selected from hydrogen; methyl; or a group selected from:

US Pat. No. 10,364,245

KINASE INHIBITORS

CHIESI FARMACEUTICI S.p.A...

1. A compound of formula (I):
wherein:
A is a group of formula (Ia), (Ib), (Ic), or (Id):

B is a group of formula (IIa), (IIb), (IIc), (IId), (IIe), (IIf), (IIg), (II h), or (Iii):

R1 is H, —CN, linear or branched (C1-C4)alkyl-, (R8)(R9)NC(O)—, R12O—(C1-C4)alkylene-, (R8)(R9)N—(C1-C4)alkylene-, (C1-C4)alkyl-C(O)O—(C1-C4)alkylene-, (R8)C(O)O—; (C1-C4)alkyl-S(O)2NH—, (C1-C4)alkyl-S—, (R8)(R9)N—, (R8)(R9)N—(C1-C4)alkylene-C(O)NH—(C1-C4)alkylene-, optionally substituted (C3-C7)heterocycloalkyl-C(O)NH—(C1-C4)alkylene-, (C1-C4)alkyl-OC(O)—, or (R8)(R9)N—(C1-C4)alkylene-O—(C1-C4)alkylene-;
R2 is H, linear or branched (C1-C4)alkyl-, or (C1-C4)alkyl-O—;
R3 is H or linear or branched (C1-C4)alkyl-;
R4 is H or linear or branched (C1-C4)alkyl-;
R5 is H, linear or branched (C1-C4)alkyl-, R12O—(C1-C4)alkylene-, or R12O—;
R6 is H or linear or branched (C1-C4)alkyl-;
R7 is H or linear or branched (C1-C4)alkyl-; or
R6 and R7 may form, together with the nitrogen atom to which they are attached, an optionally substituted 4-7 membered saturated heterocyclic monocyclic ring system, optionally containing a further oxygen or nitrogen heteroatom;
X is —CH2—, —(R3)N—, or —O—;
R8 is H, linear or branched —(C1-C4)alkyl-, or R12O—(C1-C4)alkylene-;
R9 is H, linear or branched (C1-C4)alkyl-, optionally substituted (C3-C7)heterocycloalkyl-, optionally substituted (C3-C7)cycloalkyl-, R12O—(C1-C4)alkylene-, (R10)(R11)N—(C1-C4)alkylene-, or (R10)(R11)N—(C1-C4)alkylene-O—(C1-C4)alkylene-, wherein said (C1-C4)alkylene- in (C3-C7)cycloalkyle-, R12O—(C1-C4)alkylene-, (R10)(R11)N—(C1-C4)alkylene-, and (R10)(R11)N—(C1-C4)alkylene-O—(C1-C4)alkylene may be optionally substituted with one or more groups selected from the group consisting of linear or branched (C1-C4)alkyl-, spiro-(C1-C6)cycloalkyl, and spiro-(C1-C6)heterocycloalkyl;
or R8 and R9 may form, together with the nitrogen atom to which they are attached, an optionally substituted 4-7 membered saturated heterocyclic monocyclic ring system, optionally containing a further oxygen or nitrogen heteroatom;
R10 is H, linear or branched (C1-C4)alkyl-, R12O—(C1-C4)alkylene-, (C3-C7)cycloalkyl-, or (C3-C7)heterocycloalkyl-;
R11 is H, linear or branched (C1-C4)alkyl-, or R12O—(C1-C4)alkylene-;
or R10 and R11 may form, together with the nitrogen atom to which they are attached, an optionally substituted 4-7 membered saturated heterocyclic monocyclic ring system, optionally containing a further oxygen or nitrogen heteroatom;
n is an integer from 1 to 4;
m is an integer from 1 to 2;
z is an integer from 1 to 2;
wherein “optionally substituted” means substitution by one or more groups selected from the group consisting of linear or branched (C1-C4)alkyl-, halo, R12O—(C1-C4)alkylene-, R12O—, oxo, and (C1-C4)alkyl(C1-C4)alkyl)N—;
R12 is H or linear or branched (C1-C4)alkyl-; and
the symbol * indicates the point of attachment to the rest of the molecule;
with the proviso that when A is (Ib) then R1 is not H, CH3 or CN;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,364,244

CRYSTAL FORM OF PYRROLOQUINOLINE QUINONE SODIUM SALT AND PREPARATION METHOD AND USE THEREOF

ZHEJIANG HISUN PHARMACEUT...

1. A crystal form III of pyrroloquinoline quinone disodium salt, wherein Cu target is used, and the X-ray powder diffraction pattern of the crystal form III has characteristic peaks at the following 2? diffraction angles: 7.4±0.2°, 8.6±0.2°, 14.0±0.2°, 14.6±0.2°, 19.9±0.2°, 21.4±0.2°, 26.0±0.2°, 27.3±0.2° and 28.5±0.2°.

US Pat. No. 10,364,243

2-(HET)ARYL-SUBSTITUTED FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES

BAYER CROPSCIENCE AKTIENG...


US Pat. No. 10,364,241

SUBSTITUTED PIPERIDINE COMPOUNDS

EPIZYME, INC., Cambridge...

1. A compound having Formula I:
or a pharmaceutically acceptable salt or hydrate thereof,
wherein:
B is:

X is selected from the group consisting of —S(?O)2—, S(?O)2N(R7)—, —S(?O)2C(R8)(H)—, —C(?O)—, —C(?O)N(R7)—, —C(?O)O—, —C(?O)C(R8)(H)—, and —S(?O)2N(R7)C(?O)N(R11)—; or X is absent;
wherein the sulfur atom of —S(?O)2N(R7)—, —S(O)2C(R8)(H)—, or —S(?O)2N(R7)C(?O)N(R11)— is attached to the nitrogen atom of B, the carbon atom of —C(?O)N(R7)— or —C(?O)O— is attached to the nitrogen atom of B, and the carbonyl carbon atom of —C(?O)C(R8)(H)— is attached the nitrogen atom of B;
Z is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, fluoroalkyl, (amino)alkyl, (alkylamino)alkyl, (dialkylamino)alkyl, (cycloalkylamino)alkyl, (heterocyclo)alkyl, (amino)(hydroxy)alkyl, (amino)(aryl)alkyl, (hydroxy)(aryl)alkyl, (aralkylamino)alkyl, [(cycloalkyl)alkylamino]alkyl, [(heterocyclo)alkylamino]alkyl, alkoxyalkyl, optionally substituted C6-14 aryl, optionally substituted 4- to 14-membered heterocyclo, optionally substituted 5- to 14-membered heteroaryl, optionally substituted C3-12 cycloalkyl, aralkyl, and heteroaralkyl;
R1 is selected from the group consisting of ethyl, n-propyl, isopropyl, isobutyl, and cyclopropyl;
R2a, R2b, R3a, R3b, R4a, R4b, R5a, and R5b are each independently selected from the group consisting of hydrogen, halo, C1-6 alkyl, C3-12 cycloalkyl, haloalkyl, hydroxyalkyl, optionally substituted C6-14 aryl, aralkyl, and alkoxycarbonyl; or
R2a and R2b taken together with the carbon atom to which they are attached form a C3-6 cycloalkyl; and R3a, R3b, R4a, R4b, R5a, and R5b are each independently selected from the group consisting of hydrogen, halo, and C1-4 alkyl; or
R3a and R3b taken together with the carbon atom to which they are attached form a C3-6 cycloalkyl; and R2a, R2b, R4a, R4b, R5a, and R5b are each independently selected from the group consisting of hydrogen, halo, and C1-4 alkyl; or
R4a and R4b taken together with the carbon atom to which they are attached form a C3-6 cycloalkyl; and R2a, R2b, R3a, R3b, R5a, and R5b are each independently selected from the group consisting of hydrogen, halo, and C1-4 alkyl; or
R5a and R5b taken together with the carbon atom to which they are attached form a C3-6 cycloalkyl; and R2a, R2b, R3a, R3b, R4a, and R4b are each independently selected from the group consisting of hydrogen, halo, and C1-4 alkyl; or
R2a and R5a taken together form a C1-4 bridge; and R2b, R3a, R3b, R4a, R4b, and R5b are each independently selected from the group consisting of hydrogen, halo, and C1-4 alkyl; or
R3a and R4a taken together form a C1-4 bridge; and R2a, R2b, R3b, R4a, R5a, and R5b are each independently selected from the group consisting of hydrogen, halo, and C1-4 alkyl; or
R2a and R4a taken together form a C1-4 bridge; and R2b, R3a, R3b, R4b, R5a, and R5b are each independently selected from the group consisting of hydrogen, halo, and C1-4 alkyl; or
R3a and R5a taken form a C1-4 bridge; and R2a, R2b, R3b, R4a, R4b, and R5b are each independently selected from the group consisting of hydrogen, halo, and C1-4 alkyl;
R6 is selected from the group consisting of hydrogen and C1-4 alkyl;
R7 is selected from the group consisting of hydrogen and C1-4 alkyl;
R8 is selected from the group consisting of hydrogen, C1-4 alkyl, amino, alkylamino, dialkylamino, cycloalkylamino, (amino)alkyl, (alkylamino)alkyl, (dialkylamino)alkyl, hydroxyalkyl, and —N(R9)C(?O)R10;
R9 is selected from the group consisting of hydrogen and C1-4 alkyl;
R10 is selected from the group consisting of (amino)alkyl, (alkylamino)alkyl, (dialkylamino)alkyl; and
R11 is selected from the group consisting of hydrogen and C1-4 alkyl;
with the proviso that said compound having Formula I is not:
5-cyclopropyl-N-(piperidin-4-yl)isoxazole-3-carboxamide;
N-(8-azabicyclo[3.2.1]octan-3-yl)-5-cyclopropylisoxazole-3-carboxamide;
N-(1-(2-amino-2-oxoethyl)piperidin-4-yl)-5-cyclopropylisoxazole-3-carboxamide;
5-cyclopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)isoxazole-3-carboxamide;
N-(1-benzylpiperidin-4-yl)-5-cyclopropylisoxazole-3-carboxamide;
5-cyclopropyl-N-(1-isobutyrylpiperidin-4-yl)isoxazole-3-carboxamide;
N-(1-benzoylpiperidin-4-yl)-5-cyclopropylisoxazole-3-carboxamide;
ethyl 4-(5-cyclopropylisoxazole-3-carboxamido)piperidine-1-carboxylate;
5-cyclopropyl-N-(1-(furan-3-carbonyl)piperidin-4-yl)isoxazole-3-carboxamide;
5-cyclopropyl-N-(1-((4-methoxyphenyl)sulfonyl)piperidin-4-yl)isoxazole-3-carboxamide;
5-cyclopropyl-N-(1-tosylpiperidin-4-yl)isoxazole-3-carboxamide;
5-cyclopropyl-N-(1-(2,6-dimethylpyrimidin-4-yl)piperidin-4-yl)isoxazole-3-carboxamide;
N-(1-((4-acetamidophenyl)sulfonyl)piperidin-4-yl)-5-cyclopropylisoxazole-3-carboxamide;
5-cyclopropyl-N-(1-(4-isopropyl-5-(pyridin-4-yl)pyrimidin-2-yl)piperidin-4-yl)isoxazole-3-carboxamide;
N-(1-(7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)piperidin-4-yl)-5-ethylisoxazole-3-carboxamide; or
5-ethyl-N-(1-(4-isopropyl-5-(pyridin-4-yl)pyrimidin-2-yl)piperidin-4-yl)isoxazole-3-carboxamide.

US Pat. No. 10,364,240

ARYL SULFONAMIDES

ChemoCentryx. Inc., Moun...

1. A compound of the formula (I), or a salt thereof:
where
X represents from 1 to 4 substituents independently selected from the group consisting of halogen, —CN, —NO2, —OH, —OR1, —C(O)R1, —CO2R1, —O(CO)R1, —C(O)NR1R2, —OC(O)NR1R2, —SR1, —SOR1, —SO2R1, —SO2NR1R2, —NR1R2, —NR1C(O)R2, —NR1C(O)2R2, —NR1SO2R2, —NRi(CO)NR2R3, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl, unsubstituted C2-8 alkynyl;
R1, R2 and R3 are each independently selected from the group consisting of hydrogen, unsubstituted C1-6 haloalkyl, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl; or
two of R1, R2 and R3 together with the atom(s) to which they are attached, may form an unsubstituted 5-, 6- or 7-membered ring;
Y represents from 1 to 3 substituents, each independently selected from the group consisting of halogen, —CN, —NO2, —OH, —OR4, —C(O)R4, —CO2R4, —SR4, —SOR4, —SO2R4, and unsubstituted C1-4 alkyl;
R4 is selected from the group consisting of hydrogen, unsubstituted C1-6 haloalkyl, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, and unsubstituted C2-6 alkynyl;
L is —C(O)—, —S—, —SO— or —S(O)2—; and
Z is an unsubstituted or substituted heteroaryl selected from pyrazolyl, imidazolyl, thiazolyl, and triazolyl.

US Pat. No. 10,364,239

FERROPORTIN INHIBITORS

Vifor (International) AG,...

1. A compound according to formula (A-II):
wherein
R4 indicates 1, 2 or 3 optional substituents, which may independently be selected from the group consisting of
halogen,
cyano,
optionally substituted alkyl,
optionally substituted alkoxy, and
a carboxyl group;
X1 is C, N, S or O;
X2 is C or N;
X3 is C, N, S or O; and
X4 is C, N, or S
with the proviso that 1 to 3 heteroatoms X are present,
and wherein X1, X3 and X4, when having the meaning of C or N, may carry a further substituent;
R1 is selected from the group consisting of
hydrogen and
optionally substituted alkyl;
Cycl is selected from the group consisting of
substituted aryl and
substituted or unsubstituted heteroaryl;
Q is
hydrogen or
C1-C4-alkyl, which may form a fused 5- or 6-membered ring with Cycl;
n is 0 or an integer of 1 to 8;
and
(a1) A1 is
unsubstituted linear or branched C1-C4-alkanediyl;
(a2) A2 is
linear or branched C1-C4-alkanediyl, which may be substituted with 1 or 2 substituents selected from halogen, hydroxy, an oxo group and an amino group or
a direct bond;
and
(a3) R3 is
hydrogen, or
optionally substituted alkyl;
or
(b1) A1 and R3 together with the nitrogen atom to which they are bonded form an optionally substituted 4- to 6-membered mono- or bicyclic ring;
or
(b2) R3 and A2 together with the nitrogen atom to which they are bonded form an optionally substituted 4- to 7-membered ring;
or pharmaceutically acceptable salts thereof.

US Pat. No. 10,364,238

N-((HET) ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS

Kalvista Pharmaceuticals ...

1. A compound that is:
or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,364,237

TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF ROR? AND THE TREATMENT OF DISEASE

Lycera Corporation, Ann ...

1. A method of promoting the activity of ROR?, comprising exposing a ROR? to an effective amount of a compound of Formula I or IV, or a pharmaceutically acceptable salt thereof, to promote the activity of said ROR?; wherein Formula I is represented by:
wherein:
A is phenylene or 5-6 membered heteroarylene;
R1 represents independently for each occurrence halogen, C1-6 alkyl, C1-6 haloalkyl, or C3-6 cycloalkyl;
R2A is C1-6 alkyl substituted with 1 or 2 substituents independently selected from the group consisting of —CO2R4, —N(R4)C(O)(C1-6 alkyl), —CN, halogen, hydroxyl, C1-6 alkoxy, C1-6 haloalkoxy, and —N(R4)(R5);
R2B is C1-6 alkyl, C1-3 haloalkyl, or fluoro;
R3 represents independently for each occurrence C1-6 haloalkyl, halogen, C1-6 alkyl, C1-6 alkoxy, or —O—(C1-6 alkylene)-OH;
R4 and R5 each represent independently for each occurrence hydrogen, C1-6 alkyl, or C3-6 cycloalkyl; or an occurrence of R4 and R5 attached to the same nitrogen atom are taken together with the nitrogen atom to which they are attached to form a 3-8 membered heterocyclic ring;
R9 represents independently for each occurrence C1-6 alkyl, C3-6 cycloalkyl, —(C1-6 alkylene)-(C3-6 cycloalkyl), C1-6 haloalkyl, or C1-6 hydroxyalkyl;
X is one of the following:
—(C2-6 alkenylene)-phenyl, —(C2-6 alkenylene)-heteroaryl, —(C2-6 alkenylene)-(partially unsaturated 8-10 membered bicyclic ring containing 0-3 heteroatoms), or —(C3-6 cycloalkylene)-phenyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, —S—(C1-6 alkyl), hydroxyl, cyano, —C(O)R9, and —SO2R9; or
—(C2-6 alkenylene)-(C1-6 alkyl), —(C2-6 alkenylene)-(C3-6 cycloalkyl), or

 each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, —S—(C1-6 alkyl), hydroxyl, cyano, —C(O)R9, and —SO2R9, wherein A* is a 5-8 membered, partially saturated carbocyclic or heterocyclic ring;
Y is —O—;
m and p each represent independently for each occurrence 0, 1, or 2; and
n is 1, 2, or 3; and
Formula IV is represented by:

wherein:
A is phenylene or 5-6 membered heteroarylene;
R1 represents independently for each occurrence halogen, C1-6 alkyl, C1-6 haloalkyl, or C3-6 cycloalkyl;
R2A is C1-6 alkyl substituted with 1 or 2 substituents independently selected from the group consisting of —CO2R4, —C(O)N(R4)(R5), —N(R4)C(O)R8, —CN, halogen, hydroxyl, C1-6 alkoxy, C1-6 haloalkoxy, and —N(R4)(R5); or
R2B is C1-6 alkyl, C1-3 haloalkyl, or fluoro;
R3 represents independently for each occurrence C1-6 haloalkyl, halogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, or —O—(C1-6 hydroxyalkyl);
R4 and R5 each represent independently for each occurrence hydrogen, C1-6 alkyl, or C3-6 cycloalkyl; or an occurrence of R4 and R5 attached to the same nitrogen atom are taken together with the nitrogen atom to which they are attached to form a 3-8 membered heterocyclic ring;
R8 represents independently for each occurrence C1-6 alkyl, C3-6 cycloalkyl, —(C1-6 alkylene)-(C3-6 cycloalkyl), or aryl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, hydroxyl, or —CO2R4; or R8 is —CO2R4;
R9 represents independently for each occurrence C1-6 alkyl, C3-6 cycloalkyl, —(C1-6 alkylene)-(C3-6 cycloalkyl), C1-6 haloalkyl, or C1-6hydroxyalkyl;
X is C4-7 cycloalkenyl optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6haloalkoxy, —S—(C1-6 alkyl), hydroxyl, cyano, —C(O)R9, and —SO2R9;
Y is —O—;
m and p each represent independently for each occurrence 0, 1, or 2; and
n is 1, 2, or 3.

US Pat. No. 10,364,236

COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES

Azevan Pharmaceuticals, I...

1. A unit dose comprising about 80 mg to about 700 mg total of one or more compounds of the formulae
or a salt thereof, wherein
A and A? are each independently selected from —CO2H, or an ester or amide derivative thereof;
n is an integer selected from 0 to about 3;
R1 is hydrogen or C1-C6 alkyl;
R2 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, halo, haloalkyl, cyano, formyl, alkylcarbonyl, or a substituent selected from the group consisting of —CO2R8, —CONR8R8?, and —NR8(COR9); where R8 and R8? are each independently selected from hydrogen, alkyl, cycloalkyl, optionally substituted aryl, or optionally substituted arylalkyl; or R8 and R8? are taken together with the attached nitrogen atom to form an heterocycle; and where R9 is selected from hydrogen, alkyl, cycloalkyl, alkoxyalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, and R8R8?N—(C1-C4 alkyl);
R3 is an amino, amido, acylamido, or ureido group, which is optionally substituted; or R3 is a nitrogen-containing heterocyclyl group attached at a nitrogen atom; and
R4 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkylcarbonyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted arylhaloalkyl, optionally substituted arylalkoxyalkyl, optionally substituted arylalkenyl, optionally substituted arylhaloalkenyl, or optionally substituted arylalkynyl; or

or a salt thereof, wherein
Q is oxygen; or Q is sulfur or disulfide, or an oxidized derivative thereof;
n is an integer from 1 to 3; and
R5? is selected from hydrogen, alkyl, cycloalkyl, alkoxyalkyl, optionally substituted arylalkyl, optionally substituted heterocyclyl or optionally substituted heterocyclylalkyl, and optionally substituted aminoalkyl,
where the unit dose is adapted for treating Huntington's Disease in a human, where the one or more compounds are selective for the V1a receptor compared to the V1b receptor by a factor of about 10 or greater.

US Pat. No. 10,364,235

INSECTICIDAL COMPOUNDS

Synenta Crop Protection L...

1. A compound of formula (I)
where
A1, A2, A3 and A4 are independently of each other C—H, C—R5 or nitrogen;
wherein no more than one of A1, A2, A3 and A4 is nitrogen, and
wherein no more than two of A1, A2, A3 and A4 is C—R5;
G is oxygen or sulfur;
R1 is hydrogen, C1-C8alkyl, C1-C8alkoxy-, C1-C8alkylcarbonyl- or C1-C8alkoxycarbonyl-;
R2 is a group of formula (II)

where
L is a single bond or C1-C6 alkylene; and
Y1, Y2 and Y3 are independently of another CR8R9, C?O, C?N—OR10, N—R10, S, SO, SO2, S?N—R10 or SO?N—R10, provided that at least one of Y1, Y2 or Y3 is not CR8R9, C?O or C?N—OR10;
R3 is C1-C8haloalkyl;
R4 is aryl or aryl substituted by one to five R7, or heteroaryl or heteroaryl substituted by one to five R7;
each R5 is independently halogen, cyano, nitro, C1-C8alkyl, C1-C8haloalkyl, C1-C8alkenyl, C1-C8haloalkenyl, C1-C8alkynyl, C1-C8haloalkynyl, C3-C10cycloalkyl, C1-C8alkoxy-, C1-C8haloalkoxy-, C1-C8alkylthio-, C1-C8haloalkylthio-, C1-C8alkylsulfinyl-, C1-C8haloalkylsulfinyl-, C1-C8alkylsulfonyl- or C1-C8haloalkylsulfonyl-, or
two R5 on adjacent carbon atoms together form a —CH?CH—CH?CH— bridge;
R6 is hydrogen or C1-C8alkyl;
each R7 is independently halogen, cyano, nitro, C1-C8alkyl, C1-C8haloalkyl, C2-C8alkenyl, C2-C8haloalkenyl, C2-C8alkynyl, C2-C8haloalkynyl, hydroxy, C1-C8alkoxy-, C1-C8haloalkoxy-, mercapto, C1-C8alkylthio-, C1-C8haloalkylthio-, C1-C8alkylsulfinyl-, C1-C8haloalkylsulfinyl-, C1-C8alkylsulfonyl-, C1-C8haloalkylsulfonyl-, C1-C8alkylcarbonyl-, C1-C8alkoxycarbonyl-, aryl or aryl substituted by one to five R11, or heterocyclyl or heterocyclyl substituted by one to five R11;
each R8 and R9 is independently hydrogen, halogen, C1-C8alkyl or C1-C8haloalkyl;
each R10 is independently hydrogen, cyano, C1-C8alkyl, C1-C8haloalkyl, C1-C8alkylcarbonyl-, C1-C8haloalkylcarbonyl-, C1-C8alkoxycarbonyl-, C1-C8haloalkoxycarbonyl-, C1-C8alkylsulfonyl-, C1-C8haloalkylsulfonyl-, aryl-C1-C4alkylene- or aryl-C1-C4alkylene- where the aryl moiety is substituted by one to three R12, or heteroaryl-C1-C4alkylene- or heteroaryl-C1-C4alkylene- where the heteroaryl moiety is substituted by one to three R12;
each R11 and R12 is independently halogen, cyano, nitro, C1-C8alkyl, C1-C8haloalkyl, C1-C8alkoxy-, C1-C8haloalkoxy- or C1-C8alkoxycarbonyl-;
or a salt or N-oxide thereof.

US Pat. No. 10,364,233

PIPERIDINE DERIVATIVE AND METHODS OF USE THEREOF

vTv Therapeutics LLC, Hi...

1. A compound, wherein the compound is a compound of Formula (I)
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,364,232

ANTIBACTERIAL COMPOUNDS

Janssen Sciences Ireland ...

1. A compound of formula (I)
wherein
R1 is CH;
L1 is —CH2—;
X1 is phenylene;
Xa is —CH—
q1, q2, q3 and q4 are each —CH2—;
Xb is a nitrogen atom;
L2 is S(O)2—C1-6alkyl optionally substituted by one or more fluoro atoms;
Ring A and Ring B is:

wherein SUB is halo, C1-3 alkyl or OC1-3 alkyl,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,364,230

CHROMENE-2 DERIVATIVES AND USE THEREOF IN THE TREATMENT OF FIBROSIS

ALTAY THERAPEUTICS, INC.,...

1. A compound having the following formula:
wherein
each R1 and R2 are independently selected from the group consisting of —H, methyl, ethyl, propyl, hydroxymethyl, hydroxyethyl, and hydroxypropyl; and
X is a counter anion selected from the group consisting of perchlorate, hexafluorophosphate, and tetrafluoroborate.