US Pat. No. 10,363,073

BONE ANCHOR ASSEMBLIES AND RELATED INSTRUMENTATION

1. A head insertion instrument, comprising:a sleeve having opposed arms movable towards and away from one another to selectively couple the sleeve to a head of a bone anchor assembly;
a push rod disposed within the sleeve and configured to translate axially with respect to the sleeve, the push rod having a first bearing surface; and
a release element disposed within the sleeve and configured to translate axially with respect to the sleeve and the push rod, the release element including a second bearing surface and opposed arms aligned with the opposed arms of the sleeve;
wherein the instrument prevents separation of a head of a bone anchor assembly from the sleeve when the head is not fully seated on a bone anchor.

US Pat. No. 10,363,070

PIVOTAL BONE ANCHOR ASSEMBLIES WITH PRESSURE INSERTS AND SNAP ON ARTICULATING RETAINERS

Roger P. Jackson, Prairi...

1. A pivoting bone anchor assembly, comprising:a receiver defining a chamber communicating with a first channel, the first channel sized and shaped for receiving a portion of a longitudinal connecting member, the chamber communicating with a receiver bottom opening, the receiver chamber having a spherical seating surface adjacent the bottom opening and an upper expansion region, the first channel opening onto a top of the receiver;
a shank having a lower portion integral with an upper portion extending along a longitudinal axis, the upper portion including a circumferential capture recess with an external interface surface, the upper portion further including a first radiused surface above the recess and a second radiused surface below the recess;
an insert positioned within the receiver and configured to engage the shank upper portion; and
a resilient open retainer having an internal interface surface and a third radiused surface, the retainer being expandable over the first radiused surface and snapping into the shank capture recess within the upper expansion region of the receiver chamber, with the retainer internal interface surface frictionally engaging the shank external interface surface to maintain the retainer in an expanded state, when the shank upper portion is bottom loaded into the receiver chamber through the receiver bottom opening,
wherein the second radiused surface and the third radiused surface align to define a partially spherical bearing surface to pivotably engage the spherical seating surface when the retainer internal interface surface is frictionally engaged with the shank external interface surface, and
wherein both the insert and the retainer are top-loaded into the receiver before the shank upper portion is bottom-loaded into the receiver chamber through the bottom opening.

US Pat. No. 10,363,067

SKIN CARE METHODS, SYSTEMS, AND DEVICES

1. A device to facilitate skin care, the device comprising:a digital microscope;
a comedone extractor coupled with the digital microscope, wherein the comedone extractor includes a rigid wire loop;
a spacer coupled with the digital microscope, wherein the spacer comprises at least one aperture configured to facilitate the use of the comedone extractor; and
a compressible structure coupled with the spacer, wherein the compressible structure is configured to be positioned between the spacer and the digital microscope and wherein the compressible structure coupled with the spacer is configured to preclude the comedone extractor from contacting a portion of skin when the compressible structure is in an uncompressed state and to allow the comedone extractor to contact the portion of skin when the compressible structure is in a compressed state, wherein the comedone extractor extrudes a comedone from the portion of skin when the comedone extractor applies pressure to the portion of skin and the compressible structure includes a plurality of springs.

US Pat. No. 10,363,065

MEDICAL DEVICES AND METHODS FOR MANIPULATING BODILY TISSUES

Boston Scientific Scimed,...

1. A medical device, comprising:an elongate member having a shaft, a first end portion, and a second end portion, the shaft being disposed between the first end portion and the second end portion, the shaft having a curved portion, the second end portion having a width larger than a width of the shaft, the second end portion configured to be inserted into a vagina of a patient,
the second end portion having a first surface and a second surface disposed opposite the first surface, the first surface having a planar portion and a concave portion, the concave portion being recessed from the planar portion of the first surface, the second end portion having a cutout that exposes the concave portion, the concave portion extending to a terminal end of the elongate member,
the concave portion configured to engage a cervix or uterus when the medical device is placed within a body of a patient; and
a cover member, the cover member configured to be removably coupled to the concave portion, the cover member configured to fill the concave portion.

US Pat. No. 10,363,060

ULTRASONIC SURGICAL INSTRUMENT WITH COOLING SYSTEM

COVIDIEN LP, Mansfield, ...

1. An ultrasonic surgical instrument, comprising:a handle assembly;
an outer tube extending distally from the handle assembly, the outer tube defining a first passage along a longitudinal axis;
a middle tube positioned along the longitudinal axis coaxial with the outer tube within the first passage, the middle tube defining a second passage;
a waveguide positioned along the longitudinal axis within the second passage of the middle tube;
a blade supported by a distal end of the waveguide and configured to oscillate with respect to the middle and outer tubes to ultrasonically treat tissue; and
a blade cooling system including a blade conduit extending at least partially through the blade, the blade conduit including:
a blade inlet defined in a proximal portion of the blade and disposed in fluid communication with the second passage to receive a fluid from the second passage;
a blade outlet defined in the proximal portion of the blade and in fluid communication with the first passage to expel the fluid into the first passage;
a first segment defined and extending distally within the blade from the blade inlet to a distal portion of the blade; and
a second segment defined within the blade and disposed in fluid communication with the first segment, and extending proximally from a distal portion of the blade to the blade outlet.

US Pat. No. 10,363,054

CLOT RETRIEVAL DEVICE FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL

Neuravi Limited, Galway ...

1. A clot retrieval device for removing an occlusive clot from a blood vessel comprising:a planar clot engaging element having a constrained delivery configuration and an expanded deployed configuration, the clot engaging element having a mesh between a plurality of longitudinally extending undulating edges, the clot engaging element comprising:
a first peripheral portion comprising a peak,
a second peripheral portion extended distally from the first peripheral portion, the second peripheral portion comprising a peak, and
a clot engaging section between the peaks of the first and second peripheral portions,
wherein, in the expanded configuration, the peaks of the peripheral portions are laterally spaced-apart and when under tension, configured to pinch the occlusive clot from the blood vessel between the peaks of the peripheral portions in the clot engaging section.

US Pat. No. 10,363,052

SYSTEM FOR PERFORMING AN ARTHROPLASTY PROCEDURE ON A PATIENT BONE

Howmedica Osteonics Corpo...

1. A system for use with an anchor and for performing an arthroplasty procedure on a patient bone having a surface feature, the bone having an axis associated with the bone, the axis identified in an analysis of the bone prior to using the jig assembly on the bone, the system comprising:a first component of a jig assembly comprising a mating surface and a guide hole, the mating surface being a surface negative of the surface feature of the patient bone, the mating surface configured to matingly engage the surface feature of the patient bone, the guide hole operably coupled to the mating surface of the positioning component and configured to guide the anchor into the patient bone when the mating surface matingly engages with the surface feature of the patient bone; and
a second component of the jig assembly comprising a resection guide surface configured to guide a planar resection of the patient bone that is in a pre-planned orientation relative to the axis, the second component configured to couple to the first component.

US Pat. No. 10,363,046

EXTREMITY TOURNIQUET WITH LOCKING BUCKLE

The Seaberg Company, Inc....

1. A buckle, comprising:(a) a frame having a base portion and a pair of opposite sides and defining an opening through the frame from one to the other of the opposite sides;
(b) a movable member disposed within the opening through the frame and movable between a first position with respect to the frame, in which the movable member shields an engagement member, and a second position with respect to the frame, in which at least a portion of the engagement member is exposed and extends proud of a surface of the movable member;
(c) a resiliently compressible member urging the movable member toward the first position; and
(d) a latch capable of overcoming the urging of the compressible member entirely without assistance, and arranged to be engaged automatically and thus to hold the movable member in the second position with respect to the frame, in response to the movable member moving into the second position.

US Pat. No. 10,363,045

ENDOSCOPIC SURGICAL CLIP APPLIER

Covidien LP, Mansfield, ...

11. An apparatus for application of surgical clips to body tissue, the apparatus comprising:a shaft assembly;
first and second jaw members extending from a distal end portion of the shaft assembly, the first and second jaw members movable between a spaced-apart position and an approximated position;
a drive channel positioned adjacent the first and second jaw members and configured to move the jaw members to the approximated position when the drive channel is in a distal position;
a wedge plate slidably supported in the shaft assembly, the wedge plate including a distal portion configured and dimensioned for placement between the first and second jaw members when the drive channel is in a proximal position and the first and second jaw members are in the spaced-apart position; and
a wedge plate rack mechanism supported in the shaft assembly, the wedge plate rack mechanism including,
a single gear making contact with each of the wedge plate and the drive channel such that a distal displacement of the drive channel is translated by the gear into a proximal displacement of the wedge plate and a proximal displacement of the drive channel is translated by the gear into a distal displacement of the wedge plate, wherein the proximal displacement of the wedge plate withdraws the distal portion of the wedge plate from between the first and second jaw members such that the first and second jaw members are capable of being moved to the approximated position to form a surgical clip therebetween and wherein the distal displacement of the wedge plate moves the distal portion of the wedge plate between the first and second jaw members such that the first and second jaw members are in the spaced-apart position,
wherein a portion of the single gear selectively contacts a portion of the drive channel.

US Pat. No. 10,363,043

TREATMENT OF INCOMPETENT VESSELS

ArtVentive Medical Group,...

1. An expandable device for delivery to a target location in a body vessel, comprising:a frame comprising a proximal loop, a distal loop, and first and second U-shaped link members, the first U-shaped link member having a first radius of curvature and the second U-shaped link member having a second radius of curvature, wherein the first and second radii of curvature have a common bend axis, the first U-shaped link member having a first proximal end obliquely coupled to the proximal loop at a first proximal location, the second U-shaped link member having a second proximal end obliquely coupled to the proximal loop at a second proximal location, the second proximal location being spaced apart from the first proximal location, and a second end coupled to the distal loop, the first U-shaped link member further having a first distal end obliquely coupled to the distal loop at a first distal location, the second U-shaped link member having a second distal end obliquely coupled to the distal loop at a second distal location, the second distal location being spaced apart from the first distal location, the proximal and distal loops being at opposite ends of a longitudinal axis, wherein in an expanded configuration, the first and second U-shaped link members (i) are symmetrical with each other about a first plane passing through the longitudinal axis and (ii) are each symmetrical about a second plane that is oriented perpendicular to the first plane;
wherein the frame is expandable from (1) a collapsed configuration in which the first and second U-shaped link members are generally straight and extend substantially parallel relative to the longitudinal axis, to (2) an expanded configuration, in moving to which (a) the first and second planes each rotate angularly, relative to the longitudinal axis, from the collapsed configuration by between about 10 degrees and about 170 degrees, and (b) the first and second radii of curvature decrease to cause the first and second U-shaped link members to foreshorten along the longitudinal axis to bias the proximal loop toward the distal loop; and
a cover member coupled to the frame.

US Pat. No. 10,363,040

ANASTOMOSIS DEVICES

1. An implantable medical device comprising:a barrel portion comprising a rigid frame having a first end and a second end;
a first flange portion, said first flange portion comprising a plurality of first flange members having a first length and a plurality of second flange members having a second length, said first length being less than said second length, said plurality of first flange members being discrete and separate from said plurality of second flange members;
a first hinge member formed of a cover material and flexibly coupling said first end of said barrel portion and said first flange portion, said cover material allowing said first flange portion to pivot with respect to said barrel portion;
a second flange portion, said second flange portion comprising a plurality of said first flange members and a plurality of said second flange members;
a second hinge member formed of said cover material and flexibly coupling said second end of said barrel portion and said second flange portion, said cover material allowing said second flange portion to pivot with respect to said barrel portion; and
a plurality of elongate members forming part of the rigid frame of the barrel portion, part of the first flange portion, and part of the second flange portion without the plurality of elongate members extending from the barrel portion through the first hinge member to the first flange portion and from the barrel portion through the second hinge member to the second flange portion.

US Pat. No. 10,363,039

SURGICAL FASTENER APPLIERS

Covidien LP, Mansfield, ...

1. An end effector comprising:an outer tube defining a viewing window and a lockout window, the outer tube defining a first passageway therethrough;
a coil member disposed within the first passageway of the outer tube, the coil member defining a second passageway therethrough;
a plurality of fasteners disposed in the second passageway of the coil member, the plurality of fasteners configured to translate along the second passageway; and
an engagement member disposed proximal to the plurality of fasteners and at least partially visible through the viewing window of the outer tube, the engagement member configured to translate along the second passageway proximal to the plurality of fasteners to provide a count relative to the viewing window of the plurality of fasteners remaining in the end effector, the engagement member including:
a body portion; and
a biasing portion extending from the body portion, the biasing portion having a biasing arm, the biasing arm biased resiliently outward such that engagement of a free end of the biasing portion of the engagement member with the lockout window restricts further translation of the engagement member, wherein the biasing arm of the engagement member includes a first biasing arm and a second biasing arm and wherein the outer tube includes a pair of lockout windows configured to engage with the first and second biasing arms of the engagement member.

US Pat. No. 10,363,037

SURGICAL INSTRUMENT SYSTEM COMPRISING A MAGNETIC LOCKOUT

Ethicon LLC, Guaynabo, P...

1. A surgical end effector system, comprising:a firing member comprising a cutting portion;
a staple cartridge assembly configured to be installed into said end effector system and fired by said firing member, said staple cartridge assembly comprising:
a plurality of staples;
a cartridge body comprising a slot, wherein said firing member is translatable within said slot;
an installed, ready-to-fire configuration; and
a false configuration; and
a lockout circuit system, comprising:
an electromagnet;
a severable circuit completion member electrically coupled to said electromagnet, wherein said severable circuit completion member is configured to be severed by said cutting portion, and wherein said staple cartridge assembly is in said false configuration when said severable circuit completion member is severed; and
a lockout member, comprising:
a locked position, wherein said lockout member is configured to prevent said firing member from firing said staple cartridge assembly when said lockout member is in said locked position; and
an unlocked position, wherein said lockout member is configured to permit said firing member to fire said staple cartridge assembly when said lockout member is in said unlocked position;
wherein said electromagnet is configured to release said lockout member into said locked position when said staple cartridge assembly is in said false configuration.

US Pat. No. 10,363,036

SURGICAL STAPLER HAVING FORCE-BASED MOTOR CONTROL

Ethicon LLC, Guaynabo, P...

1. A surgical stapler, comprising:a firing drive system comprising:
a movable driving member;
a gear mechanically coupled with the movable driving member; and
a shaft connected to the gear;
a handle assembly comprising a housing and a bushing block surrounded by the housing, wherein the bushing block is configured to support the shaft;
an electric motor mechanically coupled to the firing drive system;
a battery electrically couplable to the electric motor; and
a control system electrically connected to the electric motor, wherein the control system comprises:
an H-bridge circuit; and
a sensor positioned on the bushing block, wherein the control system is configured to control the electric motor based on a force applied to the bushing block by the firing drive system.

US Pat. No. 10,363,035

STAPLER TOOL WITH ROTARY DRIVE LOCKOUT

Ethicon LLC, Guaynabo, P...

1. A lockout mechanism for use with a surgical stapler, comprising:a rotary drive member;
an engagement feature disposed on the rotary drive member; and
a lockout assembly having
a lockout body disposed about the rotary drive member,
a latch pivotally coupled to the lockout body about a pivot pin such that the latch pivots between engaged and disengaged positions, the latch and pivot pin being configured to translate linearly along the lockout body between proximal and distal positions, and
a latch retainer positioned between the lockout body and the engagement feature on the rotary drive member;
wherein the latch is configured to engage the latch retainer when the latch is in the proximal position and in the engaged position such that the latch retainer prevents movement of the latch to the distal position; and
wherein the latch is configured to engage the engagement feature on the rotary drive member when the latch is in the distal position and in the engaged position such that the latch prevents rotation of the rotary drive member.

US Pat. No. 10,363,031

TISSUE THICKNESS COMPENSATORS FOR SURGICAL STAPLERS

Ethicon LLC, Guaynabo, P...

1. A circular surgical stapler, comprising:a stapler head, comprising:
a staple cartridge comprising at least one annular row of staples;
an anvil configured to be positioned opposite said staple cartridge;
an anvil shaft removably attachable to said stapler head; and
a tissue thickness compensator comprising an annular compressible biocompatible body configured to be supported on said anvil shaft between said staple cartridge and said anvil, wherein said annular compressible biocompatible body comprises at least one annular pocket, and wherein said at least one annular pocket comprises a healing agent released upon the firing of said staples.

US Pat. No. 10,363,028

METHOD FOR COUPLING SOFT TISSUE TO A BONE

Biomet Sports Medicine, L...

1. A method for forming a flexible member for coupling tissue, the method comprising:forming a first loop of a self-locking construct of the flexible member by passing a second end of the construct through a first sleeve defined by the self-locking construct proximate to a first end of the self-locking construct;
forming a second loop of the self-locking construct of the flexible member by passing the second end of the self-locking construct through a second sleeve defined proximate to an end of a flexible tail, thereby coupling the self-locking construct to the tail, and then passing the second end through a third sleeve defined by the self-locking construct proximate to the first loop;
wherein the self-locking construct is configured such that passing the tail through the first loop so that the second loop extends into the first loop and forms a tissue capture region defined by the self-locking construct; and
wherein the flexible tail defines a locking member at the second sleeve that is configured to secure the second loop to the first loop.

US Pat. No. 10,363,027

SUTURE ASSEMBLY INCLUDING A SUTURE ATTACHED TO A LEADER

1. A suture assembly engageable with a needle of a tissue suturing tool, the suture assembly comprising:a leader including a band, a clasp extending from a distal edge of the band, and at least two prongs extending from a proximal edge of the band, where the band is curved to provide the leader with an exterior surface that defines an outermost perimeter of the leader and an interior surface opposite of the exterior surface; and
a suture, with the clasp crimped onto the suture such that the suture is captured within the outermost perimeter of the leader;
wherein each of the at least two prongs is formed to have:
a curved section that forms a proximal-most end of the leader, and
a prong end coupled to the curved section, where the prong end is located closer to band than the curved section that forms the proximal-most end of the leader;
wherein the suture is one of a resorbable tissue suture and a bioabsorbable tissue suture.

US Pat. No. 10,363,024

SYSTEM FOR MENISCAL REPAIR USING SUTURE IMPLANT CINCH CONSTRUCT

Arthrex, Inc., Naples, F...

1. A system for repairing tears in soft tissue, comprising:a first implant;
a second implant;
a flexible strand connecting the first implant and the second implant;
a sliding knot in the flexible strand that is adjustable for reducing a length of the flexible strand that is located between the first implant and the second implant; and
a delivery system for implanting the first implant and the second implant into the soft tissue, wherein the delivery system includes:
a handle;
an elongated shaft connected to the handle;
a trocar assembly movable within the elongated shaft, wherein the first implant and the second implant are carried through the elongated shaft by the trocar assembly; and
a depth stop adjustable between a first position that corresponds to a first insertion distance the trocar assembly extends beyond a tip of the elongated shaft and a second position that corresponds to a second, different insertion distance the trocar assembly extends beyond the tip,
wherein the trocar assembly includes a first trocar that is slidable within a lower slot of a first hole formed in the handle and a second trocar that is removably received within an upper slot of the first hole of the handle,
wherein a first trocar handle of the first trocar abuts the depth stop when the depth stop is in the second position to limit movement of the first trocar beyond the second insertion distance.

US Pat. No. 10,363,023

LATERAL RETRACTOR SYSTEM FOR MINIMIZING MUSCLE DAMAGE IN SPINAL SURGERY

1. A lateral retractor system for forming a surgical pathway to a patient's intervertebral disc space, comprising:a dilator having a narrow body defined by opposing flat surfaces that extend between a proximal end and a distal end, the distal end tapering to a distal edge configured for insertion at an insertion orientation in which the opposing flat surfaces are parallel to a plurality of psoas muscle fibers and angled relative to the intervertebral disc space; and
a retractable dual-blade assembly consisting of two opposing blade subassemblies, each of the blade subassemblies comprising:
a blade having a planar inner surface, an outer surface, a proximal blade portion, a distal blade portion, and opposing longitudinal edges extending from a proximal end of the proximal blade portion to a distal end of the distal blade portion; and
an adjustable wing hingedly coupled with each of the opposing longitudinal edges of the blade, each adjustable wing configured to move between an open position parallel to the planar inner surface of the blade and a closed position perpendicular to the planar inner surface of the blade, the retractable dual-blade assembly configured to pass over the dilator at the insertion orientation such that the planar inner surfaces of the blades contact the opposing flat surfaces of the dilator.

US Pat. No. 10,363,022

SCREW BASED RETRACTOR WITH EXPANDABLE BLADES

SPINE WAVE, INC., Shelto...

1. A screw-based retractor, comprising:an elongate rack having a rack axis;
a plurality of arms slidably supported for translational movement on said rack toward and away from each other, each arm having an arm axis and comprising a proximal portion slidably supported by said rack and a distal portion, each said arm axis extending generally transversely relative to said rack axis, at least one of said arms including at its distal portion a curved track and a blade receptacle slidable within said curved track in a manner to provide articulation of said blade receptacle in a curved path relative to said at least one arm about an articulation point spaced from and not located on said at least one arm;
a plurality of blades, one each supported by a respective arm at the distal portion thereof, said blades projecting generally transversely relative to said rack axis and to said arm axis of said respective arms;
at least one of said blades having a proximal end defining an arm attachment and an opposing distal end defining a screw attachment, and a blade extent extending between said proximal end and said distal end, said arm attachment being releasably attached to said blade receptacle such that said blade articulates with said blade receptacle.

US Pat. No. 10,363,021

VASCULAR CLOSURE DEVICES AND METHODS PROVIDING HEMOSTATIC ENHANCEMENT

Cardiva Medical, Inc., S...

1. A device for closing a blood vessel puncture site disposed at a distal end of a tissue tract, the device comprising:a tubular shaft having a proximal end and a distal end, the tubular shaft being configured to advance through the tissue tract;
a hemostasis promoting agent deposited in hemostasis promoting region disposed on the tubular shaft near its distal end;
an expansible member disposed on the tubular shaft distal to the hemostasis promoting region, said expansible member being deployable within the blood vessel;
a tubular sealing member slidably disposed over the tubular shaft and having a distally advanced position which provides a barrier over the hemostasis promoting region and a proximally retracted position which exposes the hemostasis promoting region, and wherein the tubular sealing member has a proximal end and a distal end; and
a tensioning element disposed coaxially over the tubular shaft, under the tubular sealing member and proximal the expansible member, wherein the tensioning element has a proximal end attached to the proximal end of the tubular sealing member and a distal end attached to the tubular shaft so that proximal retraction of the tubular sealing member relative to the distal end of the tubular shaft both exposes the hemostasis promoting region and applies tension to the tubular shaft in a proximal direction to seat the expansible member against the puncture site.

US Pat. No. 10,363,011

AUTOMATIC DOSE CONTROL FOR IMAGING MEDICAL DEVICES

Siemens Healthcare GmbH, ...

1. A method for automatically calculating at least one target acquisition parameter to control a radiation dose of ionizing radiation of a region to be irradiated by an imaging device, the method comprising:acquiring patient-specific parameters, device-specific parameters, or both the patient-specific parameters and the device-specific parameters;
determining at least one anatomical target region in which the ionizing radiation is to be applied;
accessing a data store via a network, wherein a dose-protocol index for a plurality of images is stored in the data store together with associated radiation dose data for selecting at least one reference image that relates to the at least one anatomical target region or completely encompasses the at least one anatomical target region; and
automatically evaluating the at least one reference image selected with respect to the image quality and the radiation dose used, taking into account the acquired patient-specific and/or the device-specific parameters for calculating the at least one target acquisition parameter, wherein the evaluating of the image quality includes a delimitation algorithm in order to automatically analyze how adequately a respective anatomical structure is configured to be delimited from surrounding structures in the reference image.

US Pat. No. 10,363,009

METHOD AND APPARATUS FOR CORRECTION OF A SYNTHETIC ELECTRON DENSITY MAP

Siemens Healthcare GmbH, ...

1. A method for determining a corrected synthetic electron density map, the method comprising:acquiring, using a magnetic resonance (MR) device, at least one magnetic resonance image dataset taken of a patient;
determining, by a processor, a first synthetic electron density map of the patient based on the at least one magnetic resonance image dataset taken of the patient;
determining, by the processor, at least one first soft tissue image structure of the patient, at least one first bone image structure of the patient, or at least one first soft tissue image structure and at least one first bone image structure of the patient based on the first synthetic electron density map;
comparing, by the processor, the first soft tissue image structure, the first bone image structure, or the first soft tissue image structure and the first bone image structure from the first synthetic electron density map with corresponding image structures in the [ [MR]] at least one magnetic resonance image dataset taken of the patient;
determining, by the processor, a corrected synthetic electron density map, the determining of the corrected synthetic electron density map comprising correcting the first soft tissue image structure, the first bone image structure, or the first soft tissue image structure and the first bone image structure, based on the comparison; and
creating, by the processor, a plan for a radiation based treatment of a target volume of the patient based on the corrected synthetic electron density map.

US Pat. No. 10,363,006

MOBILE IMAGING SYSTEM AND METHOD

1. An alignment control system, comprising:an alignment computer comprising a central processing unit and software, the software when executed by the central processing unit cause the central processing unit to:
receive a first set of alignment data from a plurality of sensors associated to a radiation source;
receive a second set of alignment data from a plurality of sensors associated to a portable detector;
if an alignment condition between the first set of alignment data and the second set of alignment data has achieved one or more predetermined alignment conditions, send an activation signal to the radiation source to indicate that radiation may be emitted;
continuously monitor alignment conditions to prevent emission of radiation, by the radiation source, if the first set of alignment data and the second set of alignment data have not achieved the one or more alignment conditions.

US Pat. No. 10,363,001

MAGNETIC RESONANCE IMAGING APPARATUS

SAMSUNG ELECTRONICS CO., ...

1. A magnetic resonance imaging apparatus comprising:a table disposed in a cavity which is formed in a bore;
a head support having a support hole where a face of an object disposed on the table is positioned;
an abdomen support having a slope to support an abdomen of the object;
a display configured to display a graphical user interface (GUI) image, the display being disposed between the table and the head support, the display comprising a projector configured to project the GUI image and a screen on which the GUI image projected by the projector is displayed; and
a guide configured to facilitate a vertical movement of the projector;
wherein an upper surface of the table is visible to the object through the support hole,
wherein the guide has a curved shape to form the GUI image projected by the projector while vertically moving on the screen, and
wherein the screen is configured to vertically move between the head support and the upper surface of the table, in accordance with a changing position of the projector.

US Pat. No. 10,363,000

AUTOMATIC REAL-TIME CHANGES TO THE SIZE OF A PATIENTS DATA DISPLAY

KONINKLIJKE PHILIPS N.V.,...

1. A medical monitoring system comprising:one or more electronic processors configured to:
receive vital signs of each of a plurality of patients; and
dynamically configure in real-time a display of the received vital signs which includes for each patient an individually assigned patient sector display sized from available space for the display based on a priority order; and
one or more display devices which display the configured display of the plurality of patient sector displays;
wherein the priority order is based on a set of rules, the set of rules including the assignment of space to sectors based on specified minimum size, specified data elements, space assigned to all sourced vital signs, a specified maximum sector size, and an absence of sourced vital signs, the set of rules including the assignment of space:
first to sectors with a user-specified minimum size,
second to sectors with one or more user-specified data elements,
third to sectors smaller than a predetermined minimum sector size,
fourth to smaller sectors,
fifth to sectors with space assigned to all sourced vital signs,
sixth to sectors with a user-specified maximum sector size with the maximum size assigned, and
seventh to sectors with no sourced vital signs.

US Pat. No. 10,362,994

BIO-SENSING DEVICE WITH AMBIENT LIGHT CANCELLATION

TEXAS INSTRUMENTS INCORPO...

1. A bio-sensing device, comprising:a light source circuit;
a first photodetector;
a transimpedance amplifier coupled to the first photodetector and configured to convert a current produced by the photodetector to a voltage;
an analog-to-digital converter (ADC) coupled to the transimpedance amplifier and configured to convert the voltage from the first photodetector to a digital value; and
a controller coupled to the ADC and the light source circuit and configured to:
initiate a light source sense phase followed by a first ambient sense phase and a second ambient sense phase, wherein in the light source sense phase, the controller is configured to receive a digital value from the ADC while the light source circuit is enabled and wherein in each of the first and second ambient sense phases, the controller is configured to receive a digital value from the ADC while the light source circuit is disabled, wherein a first time period between the light source sense phase and the first ambient sense phase is equal to a second time period between the first and second ambient sense phases; and
iteratively vary the second time period, while maintaining the first and second time periods equal, until the digital value received during the first ambient sense phase is within a threshold of the digital value received during the second ambient sense phase.

US Pat. No. 10,362,992

SYSTEM AND METHOD FOR DETECTION OF MOTION IN DYNAMIC MEDICAL IMAGES

General Electric Company,...

1. A method for automated detection of motion, the method comprising:identifying a region of interest in each of a plurality of images corresponding to a subject of interest;
determining signal characteristics corresponding to the region of interest in each of the plurality of images;
generating a cumulative aggregate signal which includes an aggregate of the signal characteristics corresponding to the region of interest in each of the plurality of images; and
analyzing the cumulative aggregate signal to detect motion in the region of interest.

US Pat. No. 10,362,983

NEAR INFRARED PHOTONIC PROSTATOSCOPY ANALYZER

1. An infrared (IR) Photonic Analyzer System comprises an IR Scanning polarization unit for generating an illumination beam and receiving an image beam;an elongate generally cylindrical optical probe dimensioned and configured for insertion into a rectum, said optical probe defining an optical path and having a transparent optical window for transmitting an illumination beam towards a tissue of an internal organ and for receiving the image beam from the internal organ;
an illumination optical fiber transmitting said illumination beam along said optical path from said IR scanning polarization unit to said optical probe;
an image optical fiber transmitting said image beam along said optical path from said optical probe to said IR scanning polarization unit;
a first polarizer within said optical probe between said illumination optical fiber and said transparent optical window for polarizing said illumination beam with a first polarization prior to transmission along said optical path onto the internal organ;
a second polarizer within said optical probe between said transparent optical window and said image optical fiber for polarizing with a second polarization said image beam received from the internal organ along said optical path prior to transmission to said image optical fiber,
said first and second polarizations being perpendicular to each other to reduce front surface scattering and increase depth of imaging,
said IR scanning polarization unit using said illumination beam having a wavelength anywhere within at least one of the following IR tissue optical windows: Window #1 (650 nm-950 nm); Window #2 (1,100 nm-1,350 nm); Window #3 (1,600 nm-1,870 nn) and Window #4 (2,100 nm-2300 nm),
said first and second polarizers being arranged to prevent transmission of said illumination beam with said first polarization from entering said image optical fiber while enabling transmission of said image beam with said second polarization into said image optical fiber;
and means for establishing and comparing the total attenuation lengths of said image beam for non-cancerous and cancerous tissues and determining that the tissue is likely to be cancerous when its total attenuation length is equal to or less than 50% of the attenuation length of non-cancerous tissue in a corresponding one of said at least one of said IR tissue optical windows.

US Pat. No. 10,362,979

APPARATUS FOR RECOGNIZING AND LOCATING EMOTIONS AND THOUGHTS BY MEASURING THE INFRARED PULSE RADIATION

1. A measuring device for recognizing and locating of feelings and thoughts by measuring an infrared pulse radiation comprising:a locating tube;
an infrared detector;
an amplifier;
an analogous/digital conversion;
an analysis program;
a display;
the locating tube receiving infrared pulses, caused by body heat changes of a living creature and radiated from a small body surface, and partly reflected several times on an inner wall and focused on the infrared detector;
the infrared detector which is designed so that it only can receive AC signals and no DC voltage signals, converts infrared radiation into electrical signals;
the amplifier amplifying the signals;
at the analogous/digital conversion the signals being digitized;
the analysis program creating time signals, amount spectra and difference spectra for an entire measurement time or time sections in various mental dispositions of the living creature and creating a characteristic spectrum in a mental pulse frequency range of about 0.01 to 10 Hz; and
on the display results being capable of being seen in different mental states of the living creature and being compared so that various emotions including joy and sadness are visible and so that thoughts are visible.

US Pat. No. 10,362,978

COMPUTATIONAL MODEL FOR MOOD

Comcast Cable Communicati...

1. A method comprising:receiving, by a first computing device, a first plurality of natural language inputs comprising a first natural language input and a second natural language input;
determining, based on a correlation between one or more terms in the first natural language input and one or more terms in the second natural language input, that the second natural language input comprises a repetition of a portion of the first natural language input;
associating, based on the second natural language input comprising the repetition of the portion of the first natural language input, a first mood state with the first plurality of natural language inputs;
determining, based on the first mood state, a first content service; and
causing, by the first computing device, output of the first content service.

US Pat. No. 10,362,973

SYSTEMS AND METHODS FOR MONITORING AND MANAGING LIFE OF A BATTERY IN AN ANALYTE SENSOR SYSTEM WORN BY A USER

DexCom, Inc., San Diego,...

1. A method for prolonging life of a battery installed in an analyte sensor system configured to be worn by a user comprising:measuring a first analyte value at a first time;
causing a transmission of the measured first analyte value along with a predicted second analyte value;
measuring a second analyte value at a second time;
calculating a difference between the measured second analyte value and the predicted second analyte value;
determining whether the calculated difference between the measured second analyte value and the predicted second analyte value is within a predefined range;
determining that a remaining power level of the battery is less than a predetermined power level; and
responsive to the determining that the remaining power level of the battery is less than the predetermined power level and determining that the calculated difference is within the predefined range,
skipping a transmission of the measured second analyte value,
wherein the predefined range is a variable predefined range that is determined based at least partly on a clinical error grid.

US Pat. No. 10,362,967

SYSTEMS AND METHODS FOR MISSED BREATH DETECTION AND INDICATION

Covidien LP, Mansfield, ...

1. A method implemented by a ventilator for determining missed breaths, the method comprising:ventilating a patient with the ventilator, wherein the ventilator includes a pneumatic system and at least one sensor;
monitoring respiratory data of the patient with the at least one sensor;
analyzing the respiratory data with a background trigger detection application and an active trigger detection application, wherein the background trigger detection application and the active trigger detection application are different and running at the same time;
detecting a first patient inspiratory effort with the active trigger application;
detecting a second patient inspiratory effort with the background trigger application;
comparing a first timing of the first patient inspiratory effort to a second timing of the second patient inspiratory effort;
determining a timing difference between the first patient inspiratory effort and the second inspiratory effort;
comparing the timing difference to a time delay threshold;
determining that the timing difference does not meet the time delay threshold to form a missed breath determination;
calculating a missed breaths metric based on the missed breath determination;
displaying a missed breath indicator based on the missed breaths metric; and
delivering inspiratory gas to the patient with the ventilator based on patient inspiratory efforts detected by the active trigger detection application and not based on patient inspiratory efforts detected by the background trigger detection application.

US Pat. No. 10,362,965

SYSTEM AND METHOD TO MAP STRUCTURES OF NASAL CAVITY

Acclarent, Inc., Irvine,...

1. An apparatus comprising:(a) a handle assembly, wherein the handle assembly comprises
(i) a body,
(ii) a cable configured to communicate an electrical signal to a navigation system, and
(iii) a first portion of an adapter coupled with a distal end of the cable;
(b) a guide tube extending distally from the handle assembly, wherein the guide tube has a distal end; and
(c) a cartridge assembly configured to be removably coupled with the handle assembly, wherein the cartridge assembly includes:
(i) an actuator, wherein the actuator is movable relative to the body to move the wire relative to the guide tube, and
(ii) a wire coupled with the actuator and configured to communicate an electrical signal to the cable, wherein the wire is slidably disposed in the guide tube, wherein the wire includes:
(A) a distal end including a sensor, wherein the distal end of the wire is configured to translate relative to the body,
(B) a proximal end that terminates at a second portion of the adapter, wherein the second portion of the adapter is configured to be removably coupled with the first portion of the adapter, wherein the proximal end is fixed relative to the body, and
(C) an intermediate portion configured to gather within the body as a service loop to provide freedom of movement of the distal end of the wire relative to the body as the distal end of the wire translates proximally relative to the body,
wherein the sensor is configured to cooperate with the navigation system to generate a map of anatomical structures within a patient.

US Pat. No. 10,362,963

CORRECTION OF SHIFT AND DRIFT IN IMPEDANCE-BASED MEDICAL DEVICE NAVIGATION USING MAGNETIC FIELD INFORMATION

ST. JUDE MEDICAL, ATRIAL ...

1. A system for navigating a medical device within a body, comprising:an electronic control unit configured to:
determine an operating position for a first electrical position sensor on said medical device within a first coordinate system, said first coordinate system defined by an electric field based positioning system;
determine an operating position for a first magnetic position sensor on said medical device within a second coordinate system, said second coordinate system defined by a magnetic field based positioning system, said first magnetic position sensor disposed proximate said first electrical position sensor;
apply a first mapping function correlating said operating positions of said first electrical position sensor and said first magnetic position sensor, said first mapping function generating a mapped position for said first magnetic position sensor in said first coordinate system responsive to said operating position of said first magnetic position sensor in said second coordinate system wherein said first mapping function describes a three-dimensional input and a three-dimensional output that generates said mapped position;
determine a first difference between said operating position for said first electrical position sensor and said mapped position for said first magnetic position sensor; and
modify said operating position for said first electrical position sensor by said first difference to obtain a first adjusted operating position;
wherein said electronic control unit is further configured to:
determine a planning position for said first electrical position sensor within said first coordinate system;
determine a planning position for said first magnetic position sensor within said second coordinate system;
compute said first mapping function responsive to said planning positions for said first electrical position sensor and said first magnetic position sensor; and,
responsive to the first adjusted operating position, displaying on a graphical user interface the first adjusted operating position of the first electrical position sensor of the medical device.

US Pat. No. 10,362,961

SYSTEM AND METHOD FOR NEUTRAL CONTRAST MAGNETIC RESONANCE IMAGING OF CALCIFICATIONS

NORTHSHORE UNIVERSITY HEA...

1. A method for producing an image of a subject using a magnetic resonance imaging (MRI) system, the steps of the method comprising:a) directing the MRI system to generate a radio frequency (RF) excitation field to excite spins in an imaging volume, the RF excitation field having a flip angle in a range from an Ernst angle for blood to an Ernst angle for muscle;
b) directing the MRI system to acquire data at an echo time at which spins associated with water are substantially in-phase with spins associated with fat;
c) reconstructing an image from the acquired data, the image in which water, fat, blood, and muscle tissues have substantially similar image intensity values and calcifications have image intensity values that are significantly different from the image intensity values of the water, fat, blood, and muscle tissues in the image.

US Pat. No. 10,362,960

MULTI POINT TREATMENT PROBES AND METHODS OF USING THEREOF

Renal Dynamics Ltd., Roa...

1. A system of intrabody treatment, comprising:a multi point probe transported by a catheter to a lumen of a body of a treated patient, the multi point probe having at least two transmission points; and
a processor configured to:
select a transmission pattern including for each of the at least two transmission points, a respective signal of a plurality of radio frequency transmission signals, said transmission pattern forms at least one interaction between the respective signals from the at least two transmission points, the at least one interaction defines at least one hot spot at the treatment location; and
control delivery of the respective signals from the transmission points;wherein the processor determines a timing for each of said respective signals.

US Pat. No. 10,362,957

SYSTEM AND METHODS FOR PERFORMING NEUROPHYSIOLOGIC ASSESSMENTS DURING SPINE SURGERY

NuVasive, Inc., San Dieg...

1. A system for performing neurophysiologic assessments during surgery, comprising:a first stimulator configured to deliver a first set of electrical stimulation signals to the motor cortex of a patient;
a first sensor configured to detect at least one motor evoked potential response evoked by the first set of electrical stimulation signals of the first stimulator;
a second stimulator configured to deliver a second set of electrical stimulation signals to a peripheral nerve of a patient;
a second sensor configured to detect at least one somatosensory evoked potential response evoked by the second set of electrical stimulation signals of the second stimulator; and
a control unit in communication with the first and second stimulators and the first and second sensors, the control unit being configured to (a) selectively operate in either trans-cranial electrical motor evoked potential (“MEP”) monitoring mode or somatosensory evoked potential (“SSEP”) monitoring mode; (b) accept user input to toggle between MEP monitoring mode and SSEP monitoring mode; (c) accept user input to initiate stimulation in the MEP monitoring mode or SSEP monitoring mode; and (d) communicate an onscreen assessment of a spinal cord health status to be displayed to a user in response to the potential response evoked by said first or second set of electrical stimulation signals.

US Pat. No. 10,362,955

GRAPHICALLY MAPPING ROTORS IN A HEART

Regents of the University...

1. A method, comprising:receiving, using a processor, an electrogram for each of a plurality of spatial locations in a heart, each electrogram comprising time series data including a plurality of electrical potential readings over time;
generating, from the time series data, a dataset, the dataset including a plurality of values using a mathematical approach, wherein the mathematical approach is either a multi-scale frequency (MSF) approach, a kurtosis approach, an empirical mode decomposition (EMD) approach, or a multi-scale entropy (MSE) approach; and
graphically indicating pivot points of rotors associated with atrial or ventricular fibrillation according to the dataset;
wherein the dataset is a first dataset, the plurality of values is a first plurality of values, and the mathematical approach is a first mathematical approach, and wherein the method further comprises:
generating, from the time series data, a second dataset, the second dataset including a second plurality of values using a second mathematical approach that is different from the first mathematical approach, wherein the second mathematical approach is either a multi-scale frequency (MSF) approach, a kurtosis approach, an empirical mode decomposition (EMD) approach, or a multi-scale entropy (MSE) approach depending on the first mathematical approach used; and
graphically indicating pivot points of rotors associated with atrial or ventricular fibrillation according to the second dataset.

US Pat. No. 10,362,949

AUTOMATIC EXTRACTION OF DISEASE-SPECIFIC FEATURES FROM DOPPLER IMAGES

International Business Ma...

1. A method for automatic extraction of disease-specific features from Doppler images, comprising:obtaining a raw Doppler image from a series of images of an echocardiogram;
isolating a region of interest from the raw Doppler image, the region of interest (i) including a Doppler image and an electrocardiogram (ECG) signal, and (ii) depicting at least one heart cycle;
determining a velocity envelope of the Doppler image in the region of interest;extracting the electrocardiogram (ECG) signal by detecting the electrocardiogram (ECG) signal using an energy maximization equation:E(i,j)=?1Econtinuity(i,j)+?2Ecolor(i,j)+?3Egradient(i,j)+?4Enotgray(i,j)
wherein E(i,j) is an energy value, Econtinuity(i,j) is a continuity of the electrocardiogram (ECG) signal, Ecolor(i,j) is a color profile of the electrocardiogram (ECG) signal, Egradient(i,j) is a gradient between the color profile of the electrocardiogram (ECG) signal and a background of the image, Enotgray(i,j) is RGB value of the electrocardiogram (ECG) signal that is not gray, and each of, ?1, ?2, ?3, and ?4 is a weighting factor, and
synchronizing the extracted the electrocardiogram (ECG) signal with the Doppler image over the at least one heart cycle, within the region of interest;
calculating a value of a clinical feature based on the extracted the electrocardiogram (ECG) signal synchronized with the velocity envelope; and
comparing the value of the clinical feature with clinical guidelines associated with the clinical feature to determine a diagnosis of a disease.

US Pat. No. 10,362,946

MEASUREMENT OF CARDIAC CYCLE LENGTH AND PRESSURE METRICS FROM PULMONARY ARTERIAL PRESSURE

Medtronic, Inc., Minneap...

21. A computer readable medium comprising computer executable instructions that, when executed, cause a processor of an implantable medical device to:control sensing of the cardiovascular pressure signal;
compare the sensed cardiovascular pressure signal to a first threshold;
identify a first sense in response to the sensed cardiovascular pressure signal exceeding the first threshold;
in response to and as a result of identifying the first sense, compare the sensed cardiovascular pressure signal to a second threshold not equal to the first threshold;
identify a second sense subsequent to the first sense if the sensed cardiovascular pressure signal exceeds the second threshold;
identify a third sense subsequent to the first sense and in response to the sensed cardiovascular pressure signal exceeding the first threshold; and
determine a cardiac cycle length based on one of the first sense and the third sense or the second sense and the third sense.

US Pat. No. 10,362,944

OPTICAL DETECTION AND ANALYSIS OF INTERNAL BODY TISSUES

Samsung Electronics Compa...

1. An electronic device comprising:a band;
one or more light sources coupled to the band and configured to emit light in a first direction that penetrates into a portion of a user's body;
a plurality of light sensors coupled to the band and configured to detect a pattern of diffusion of the emitted light, wherein:
at least one first light sensor is located near the light source and configured to detect light travelling in a second direction that is between 90 degrees and 270 degrees from the first direction;
at least one second light sensor located between 90 degrees and 270 degrees from the light source and configured to detect light travelling between 90 degrees and ?90 degrees from the first direction; and
the one or more light sources and the plurality of light sensors are positioned in a matrix configuration comprising a plurality of rows of light sensors with the one or more light sources interspersed within the matrix configuration; and
a controller configured to detect a gesture made by the user based on the detected pattern of diffusion of the emitted light by cycling through different configurations of active light sources of the one or more light sources of the matrix configuration.

US Pat. No. 10,362,943

DYNAMIC OVERLAY OF ANATOMY FROM ANGIOGRAPHY TO FLUOROSCOPY

Siemens Healthcare GmbH, ...

1. A method for generating an overlay of anatomy in a fluoroscopy image, the method comprising:acquiring, with an angiograph, an angiograph image representing the anatomy of a patient at a first phase of a first cardiac cycle of the patient;
acquiring, with a fluoroscope, a fluoroscopic image representing the anatomy of the patient at a first phase of a second cardiac cycle of the patient;
determining, by a processor, a shape of the anatomy in the fluoroscopic image from the angiograph image; and
generating the overlay of the anatomy as a graphic on the fluoroscopic image, the overlay being a function of the shape determined from the angiograph image.

US Pat. No. 10,362,942

MICROMETER SIZE MULTI-FUNCTIONAL PROBE FOR OCT AND ELECTRO-PHYSIOLOGICAL RECORDING

1. A probe for tissue recording in a medical procedure, comprising:a flexible optical fiber for optical coherence tomography imaging, having an optical fiber distal end, an optical fiber proximal end and an optical fiber length extending from the optical fiber distal end to the optical fiber proximal end;
a metal coating surrounding the optical fiber length for recording electrical signals, having a metal coating distal end and a metal coating proximal end;
an electrophysiological recording system connected to the metal coating proximal end; and
an outer insulation coating surrounding the metal coating, wherein the insulation coating is discontinuous in proximity to the metal coating distal end, thereby providing contact between the metal coating and the tissue for receiving an electrical signal from the tissue.

US Pat. No. 10,362,939

FUNDUS ANALYSIS APPARATUS AND FUNDUS OBSERVATION APPARATUS

TOHOKU UNIVERSITY, Senda...

1. A fundus analysis apparatus, comprising:a memory that stores OCT information acquired by applying optical coherence tomography to a fundus of an eye; and
a processing circuitry configured to:
set a front area corresponding to a front surface of a lamina cribrosa and a rear area corresponding to a rear surface of the lamina cribrosa in the OCT information,
specify an image area that corresponds to an orientation of holes of the lamina cribrosa based on the OCT information, the orientation of the holes determined in accordance with a (i) B-scan image of the lamina cribrosa and (ii) an approximation of a direction of the holes from the front surface to the rear surface, and
 generate morphological information indicating the holes of the lamina cribrosa based on at least (i) the front area, (ii) the rear area, and (iii) the orientation of the specified image area.

US Pat. No. 10,362,938

FUNDUS IMAGE FORMING DEVICE

NIKON CORPORATION, Tokyo...

1. A fundus imaging system configured to scan a retina of a subject with a light beam, the system comprising:a reflection mirror configured to reflect a light beam incident on the reflection mirror after passing through a first focus so as to cause the light beam to pass through a second focus;
a two-dimensional scanning unit that is disposed at a position that coincides with a position of the first focus of the reflection mirror and configured to reflect a light beam incident on the two-dimensional scanning unit so as to perform scanning with the light beam in two-dimensional directions;
a detecting unit configured to detect a light beam reflected off the retina; and
a compensating unit configured to correct a detection result of an intensity of the light beam detected by the detecting unit, based on at least one of a scan angle or a scan timing at which the two-dimensional scanning unit performs scanning, so as to compensate for illuminance non-uniformity of the light beam illuminating the retina, the illuminance non-uniformity resulting from an unevenness of a ratio of an angular change of a light beam emitted from the first focus during scanning of the two-dimensional scanning unit to an angular change of a light beam incident on the second focus after being reflected by the reflection mirror.

US Pat. No. 10,362,937

CORNEA TRANSPLANTATION

Carl Zeiss Meditec AG, J...

10. A method for transplanting corneal material from a donor cornea of an eye of a donor to a patient cornea of an eye of a patient, and for correcting refractive deficiencies of the patient cornea, comprising:using a measurement device to measure parameters of the eye of the patient and obtain measurement data relating to parameters of the cornea, including measurement data defining a geometry of the eye of the patient, the geometry including a pre-transplantation shape of a front surface of the patient cornea,
transmitting the measurement data to a computer interface of a planning device;
based on the measurement data received from the computer interface of the planning device, using a computer of the planning device to automatically determine:
a previously-present refractive deficiency of the eye, and a change of the pre-transplantation shape of the front surface of the patient cornea, the change being required to correct the previously-present refractive deficiency of the eye,
boundary surfaces in the patient cornea, the boundary surfaces in the patient cornea defining a patient corneal volume to be removed from the patient cornea, the boundary surfaces in the patient cornea including an anterior cut surface lying beneath the front surface of the patient cornea, and a posterior cut surface lying beneath the front surface of the patient cornea, the boundary surfaces in the patient cornea defined such that the patient corneal volume is initially surrounded by corneal tissue of the patient cornea and is beneath the front surface of the patient cornea,
boundary surfaces in the donor cornea, the boundary surfaces in the donor cornea defining a transplant corneal volume to be removed from the donor cornea, the boundary surfaces in the donor cornea including an anterior boundary surface lying beneath a front surface of the donor cornea, and a posterior cut surface lying beneath the front surface of the donor cornea, the boundary surfaces in the donor cornea defined such that the transplant corneal volume is initially surrounded by corneal tissue of the donor cornea and is beneath the front surface of the donor cornea, and wherein a size of the transplant corneal volume differs from a size of the patient corneal volume;
generating control data sets for controlling a laser device of a treatment apparatus, including generating a transplant control data set, and generating a patient control data set,
transmitting the control data sets to the treatment apparatus,
generating the boundary surfaces in the donor cornea;
separating the transplant donor volume from the donor cornea;
generating the boundary surfaces in the patient cornea by controlling the laser device using the patient control data set, thereby isolating the patient corneal volume,
removing the patient corneal volume, and
inserting the transplant corneal volume, which has a different size as compared to the patient corneal volume, into the eye of the patient;
wherein automatically determining the boundary surfaces defining the patient corneal volume and the transplant corneal volume includes defining a deviation between the size of the patient corneal volume and the size of the transplant corneal volume, the deviation causing a change in the geometry of the eye of the patient, including a change in the pre-transplantation shape of the front surface of the patient cornea once the transplant corneal volume replaces the patient corneal volume, to correct the previously-present refractive deficiency.

US Pat. No. 10,362,936

METHODS OF PERFORMING SURGERY USING OPTICAL COHERENCE TOMOGRAPHY (OCT)

Bioptigen, Inc., Morrisv...

1. A method for performing a surgical procedure using an optical coherence tomography (OCT) imaging system, the method comprising:imaging a surgical region of the subject that contains a structure having a known orientational asymmetry to obtain an OCT image using the OCT imaging system;
testing the OCT image for presence and location of the structure;
confirming correct orientation of the subject using the OCT image of the structure having the known orientational asymmetry;
obtaining at least one image of the surgical region of the subject using OCT and constructing an initial structural view of the surgical region;
computing at least one clinical parameter relevant as an end point for assessing an outcome of the surgical procedure using data derived from the OCT image;
periodically assessing the surgical procedure progression and monitoring clinical outcomes related to the surgical procedure using changes to an OCT-derived structural view of the surgical region and changes to the computed clinical parameters derived from the at least one OCT image;
determining if a surgical plan for the surgical procedure needs modification based on at least one of the periodically assessing and monitoring;
modifying the surgical plan for the surgical procedure in real time if it is determined modification is needed; and
repeatedly assessing and monitoring, determining and modifying until it is determined that further modification is not needed,
wherein computing clinical parameters for the surgical procedure comprises computing at least one of a cornea thickness, a cornea curvature, a lens thickness, a lens curvature, a cornea refractive power, a lens refractive power, an iridocorneal angle, a sclera thickness, a conjunctival thickness, a direction of an optical axis, an orientation of a refractive astigmatism, a thickness of a an edema, a length of a tissue membrane or tear, a width of a surgical incision, a map or a count of surgical debris within a surgical field, a map or measure of degree of contact between an implanted device and surrounding tissue, and orientation of an implanted device relative to a neighboring structure or an optical or physical axis; and,
wherein the computing includes computing from measurements derived from the at least one image.

US Pat. No. 10,362,934

SYSTEM AND METHOD FOR THE RAPID MEASUREMENT OF THE VISUAL CONTRAST SENSITIVITY FUNCTION

1. A method for implementing a tilted-grating, forced choice contrast sensitivity function test, the method comprising the steps of:presenting a patient with a first series of randomized test chart sets having patterns with two or more choices per set on a high resolution display of 10 bit depth or greater as a video and covering a first range of frequencies and contrasts, the high resolution display being shielded from ambient light that interferes with the test and connected to a processor and associated memory for implementing an algorithm for the contrast sensitivity function test, and wherein the algorithm ensures that the test charts are sized to maintain a predetermined viewing distance between the patient and the display;
having the patient select a response from the two or more choices, automatically recording if the response is correct or incorrect and the time for the patient to make the selection, and providing the patient with additional choices until the first series of test charts are complete and a contrast sensitivity function is generated to a desired precision based upon an analysis of the responses;
analyzing the responses utilizing statistical methods;
providing the patient with an ophthalmic solution to increase visual performance based upon the analyzed results;
repeating the method until a desired ophthalmic resolution is obtained as determined by an adaptive algorithm; and
storing and plotting the contrast sensitivity function to provide an accurate quantitative result for the contrast sensitivity function.

US Pat. No. 10,362,932

MEDICAL DEVICE ILLUMINATOR AND CHARGING SYSTEM

Welch Allyn, Inc., Skane...

1. A method for enabling a medical examination, the method comprising:providing a medical device; and
providing an illuminator that is releasably attachable to the medical device, the illuminator comprising a housing containing a light source, a rechargeable battery that powers the light source, and an inductive charging coil, the inductive charging coil being in stacked arrangement with the rechargeable battery, the inductive charging coil permitting the battery of the illuminator to be recharged using a non-contact charging device,
wherein the medical device is a vaginal speculum and in which the method further comprises:
attaching the illuminator housing to an inner surface of a blade of the vaginal speculum.

US Pat. No. 10,362,930

ENDOSCOPE APPARATUS

OLYMPUS CORPORATION, Tok...

1. An endoscope apparatus comprising:a light source configured to emit one of white illumination light and narrow band illumination light, the white illumination light including red wavelength band light, green wavelength band light, and blue wavelength band light, and the narrow band illumination light having a narrow wavelength band included in each of the blue wavelength band light and the green wavelength band light;
an image sensor having a plurality of pixels, wherein each pixel is configured to receive light, the plurality of pixels being arranged in a lattice pattern, and the image sensor being configured to perform photoelectric conversion on the light received by each of the plurality of pixels to generate an electric signal;
a color filter comprising a filter unit arranged corresponding to the plurality of pixels, the filter unit including a plurality of filters having at least a filter for passing the blue wavelength band light, and a filter for passing the blue wavelength band light and at least one of the green wavelength band light and the red wavelength band light, the number of the filters for passing the green wavelength band light being equal to or greater than half of the number of all the filters of the filter unit, and the number of the filters for passing the blue wavelength band light being equal to or greater than the number of the filters for passing the green wavelength band light; and
a hardware processor configured to:
select, from the plurality of pixels, a luminance component pixel for receiving light of a luminance component, wherein the luminance component is among a plurality of color components, and the selection of the luminance component pixel is based on a control signal indicating a type of illumination light emitted by the light source;
generate a luminance component value based on a pixel value of the selected luminance component pixel;
generate at least one color component value based on the generated luminance component value, wherein the at least one color component value correspond to color components different from the luminance component; and
generate a color image signal, based on the generated luminance component value and the generated color component values, wherein the color image signal corresponds to an image comprising pixels that includes the luminance component.

US Pat. No. 10,362,929

IMAGING UNIT, IMAGING MODULE, AND ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. An imaging unit comprising:a semiconductor package being a chip size package, the semiconductor package including:
an image sensor, and
a connection electrode formed on a back surface of the semiconductor package;
a circuit board being accommodated in a projection plane in an optical axis direction of the semiconductor package, the circuit board including:
a main body including a connection land formed on a front surface, the connection land being electrically and mechanically connected to the connection electrode via a bump, and
an attachment portion protruding on a back surface of the main body and including cable connection electrodes formed on at least two opposing side surfaces among protruding side surfaces;
a plurality of electronic components mounted on an electronic component mounting area on the back surface of the main body of the circuit board; and
a plurality of cables electrically and mechanically connected to the cable connection electrodes of the attachment portion,
wherein the attachment portion protrudes from the main body such that a center plane of the two side surfaces on which the cable connection electrodes are formed to oppose each other is shifted from a center plane of side surfaces of the semiconductor package which are parallel to the two side surfaces of the attachment portion, and at least one side surface is perpendicular to the back surface of the main body,
the electronic component mounting area is arranged side-by-side with the attachment portion on a same plane as the attachment portion,
each of the two opposing side surfaces of the attachment portion including the cable connection electrode formed thereon includes:
a first step portion on the main body side; and
a second step portion on the proximal end side in the optical axis direction of the image sensor; and
the cable connection electrodes are formed on:
a side surface of the second step portion on the electronic component mounting area side;
a side surface of the second step portion opposing the side surface on the electronic component mounting area side; and
the side surface of the first step portion opposing the side surface on the electronic component mounting area side.

US Pat. No. 10,362,927

ENDOSCOPE WITH PANNABLE CAMERA

DEKA Products Limited Par...

1. An endoscope having a proximal handle assembly and a distal insertion shaft; the insertion shaft having a distal portion that includes a camera assembly; the insertion shaft comprising a liquid carrying conduit;the camera assembly comprising an electronic image sensor;
the proximal handle assembly comprising a proximal housing and a distal housing;
the distal housing and the insertion shaft connected together and rotatable together relative to the proximal housing;
the liquid carrying conduit including a wired connection extending from the camera assembly to a printed circuit board attached to the distal housing, the wired connection being exposed to any liquids carried by the conduit; wherein
the proximal housing of the handle assembly comprises a liquid passageway in fluid communication with the liquid carrying conduit of the insertion shaft.

US Pat. No. 10,362,926

LOW-COST INSTRUMENT FOR ENDOSCOPICALLY GUIDED OPERATIVE PROCEDURES

CooperSurgical, Inc., Tr...

1. An endoscopic device, comprising:a single-use portion, comprising:
an elongate conduit comprising a proximal portion and comprising a distal portion configured for insertion into a uterus of a patient, the distal portion defining a distal opening through which fluid can be delivered to the uterus,
an imaging system disposed along the distal portion of the elongate conduit for imaging the uterus,
an electrical cable extending from the proximal portion of the elongate conduit to the imaging system,
a fluid hub connected to the proximal portion of the elongate conduit, the fluid hub comprising a fluid connection port and a gasket at which a first seal is provided, and
a sliding connector attached to a proximal end of the fluid hub that isolates fluid to the single-use portion, the sliding connector comprising:
an outer shell, and
a fluid barrier disposed within the outer shell and surrounding the electrical cable, wherein the fluid barrier and the electrical cable together form a second seal at a distal end of the fluid barrier, and wherein the fluid barrier and the electrical cable together form a third seal located proximal to the second seal and along a radial projection of the electrical cable that seats within a radial recess of the fluid barrier; and
a multiple-use portion configured to be attached to and detached from the single-use portion, the multiple-use portion comprising:
a handle coupled to the proximal end of the outer shell of the sliding connector and being located proximal to the sliding connector and to the fluid hub such that the handle, the sliding connector, the fluid hub, and the elongate conduit are arranged in an in-line configuration, and
an integral image display located proximal to the handle and electrically coupled to the imaging system by the electrical cable.

US Pat. No. 10,362,924

JET UNIT, JET NOZZLE AND MANUFACTURING METHOD THEREOF, AND DISH WASHING MACHINE HAVING THE SAME

SAMSUNG ELECTRONICS CO., ...

1. A dish washing machine comprising:a cabinet configured to form an exterior;
a washing tub provided in the cabinet to wash dishes; and
a jet nozzle configured to jet washing water to the washing tub,
wherein the jet nozzle comprises a plurality of inner walls of a passage through which the washing water passes, and at least one of the plurality of inner walls has a cross sectional area formed in an arc shape that is convex in an outer circumferential direction of the jet nozzle, and
wherein the plurality of nozzle inner walls extends to the end of the jet nozzle for linearity of the washing water sprayed from the jet nozzle.

US Pat. No. 10,362,923

VALVE FOR A SPRAY ARM OF A DISHWASHER APPLIANCE

Haier US Appliance Soluti...

1. A dishwasher appliance defining a lateral direction, a transverse direction, and a vertical direction, the lateral, transverse, and directions mutually perpendicular to one another, the dishwasher appliance comprising:a cabinet defining a wash chamber for receipt of articles for washing;
a spray arm disposed within the wash chamber, the spray arm defining an interior and an aperture providing selective fluid communication between the interior and the wash chamber;
a valve positioned within the interior of the spray arm;
a sensor operable to detect a pressure of a fluid flowing from a pump of the dishwasher appliance to the interior of the spray arm; and
a controller communicatively coupled to the sensor, the controller configured to determine a rotational speed of the spray arm based, at least in part, on the detected pressure of the fluid,
wherein the spray arm is rotatable between a first position wherein the valve allows fluid communication between the interior and the wash chamber through the aperture, and a second position wherein the valve obstructs fluid communication between the interior and the wash chamber through the aperture.

US Pat. No. 10,362,921

CLEANER

LG ELECTRONICS INC., Seo...

1. A cleaner, comprising:a cleaner body having a controller;
a wheel cover mounted to the cleaner body;
a motor that is connected to the wheel cover and generates a driving force;
a wheel that is coupled to the motor and rotates based on receiving the driving force from the motor;
a guide bar coupled to the wheel cover and extending vertically, the guide bar being connected to the motor to guide a vertical movement of the motor;
a spring surrounding the guide bar and connected to the wheel cover and the motor to absorb impacts during the vertical motion of the motor;
a case having a through-hole into which the guide bar is inserted, the motor being mounted on the case such that a movement of the case along the guide bar guides the vertical movement of the motor; and
a planetary gear train that connects the motor and the wheel, the planetary gear train receiving the driving force from the motor and transferring the driving force to the wheel,
wherein a rotating shaft of the motor and the wheel are coaxially arranged.

US Pat. No. 10,362,919

CLEANING ROBOT AND METHOD FOR CONTROLLING THE SAME

SAMSUNG ELECTRONICS CO., ...

1. A cleaning robot comprising:a main body;
a moving assembly mounted on a bottom surface of the main body to perform forward movement to move the main body in a first direction that is a traveling direction of the main body, backward movement to move the main body in a second direction opposite to the first direction, and rotation to rotate the main body within a predetermined range to change the traveling direction of the main body;
a cleaning tool assembly mounted on the bottom surface of the main body to clean a floor;
a detector to detect an obstacle around the main body; and
a controller to determine whether an obstacle is present in front of the main body in the traveling direction based on a detection signal of the detector, control the rotation of the main body to determine whether the main body rotates by an angle equal to or greater than a predetermined angle upon determining that the obstacle is present, and determine that the main body is in a stuck state to control the backward movement of the main body when the main body rotates by an angle less than the predetermined angle.

US Pat. No. 10,362,915

VACUUM CLEANER

LG Electronics Inc., Seo...

1. A vacuum cleaner comprising:a cleaner body;
a pair of wheels provided at both side surfaces of the cleaner body and configured to rotate about a rotating center; and
a rear wheel unit provided at a bottom surface of the cleaner body and configured to provide an upward elastic force at a position rearward of the rotating center of the pair of wheels,
wherein the cleaner body is configured to pivot about the rotating center and has a center of gravity that is located closer to a rear end of the cleaner body than the rotating center,
wherein the rear wheel unit includes:
a supporting part that is rotatably coupled to the bottom surface of the cleaner body and configured to rotate in a pivoting direction of the cleaner body,
an elastic portion that is coupled to the supporting part and that is configured to be elastically deformed based on the supporting part being rotated,
a rotating member that is rotatably coupled to the supporting part and configured to rotate in a direction that is transverse to the rotating direction of the supporting part, and
a rear wheel that is provided at the rotating member and configured to roll on ground.

US Pat. No. 10,362,913

CLEANING APPARATUS DATA MANAGEMENT SYSTEM AND METHOD

Diversey, Inc., Fort Mil...

1. A mobile cleaning machine comprising:a chassis;
a communications module configured to communicate with a device remote from the mobile cleaning machine;
a sensor operable to sense one or more characteristics of the mobile cleaning machine; and
a controller including a processor and memory, the processor programmed to perform instructions stored in the memory, the instructions including
receiving the one or more characteristics of the mobile cleaning machine sensed by the sensor,
receiving a non-mobile cleaning machine data set from the remote device, and
transmitting, via the communications module, at least one of the one or more characteristics of the mobile cleaning machine and the non-mobile cleaning machine data set to a central location.

US Pat. No. 10,362,910

HAND DRYER DEVICE

CHICONY POWER TECHNOLOGY ...

1. A hand dryer device used to cooperate with a home appliance having an airflow driver, comprising:a first housing having a first body and a first extension portion, wherein the first extension portion is connected to the first body;
a second housing disposed corresponding to the first housing and having a second body and a second extension portion, wherein the second extension portion is connected to the second body, the second body is connected to the first body for defining an accommodating space, the second extension portion and the first extension portion together form a concave annular structure, the concave annular structure has an extension space therein, and the home appliance is received in the accommodating space; and
an airflow driving unit disposed in the accommodating space and the extension space, and comprises:
a sensor disposed on an outer surface of the first housing and/or the second housing, wherein the sensor detects and outputs a sensing signal,
a control module receiving the sensing signal and outputting a control signal to enable the airflow driver of the home appliance to output a strong airflow, and
an airflow guiding structure disposed adjacent to an air outlet of the airflow driver and extending to the extension space.

US Pat. No. 10,362,904

FOOD PROCESSOR SYSTEM

SHARKNINJA OPERATING LLC,...

1. A base for a food processing system, comprising: a housing configured to couple with a complementary container, the housing including a bottom surface;at least one suction device mounted to the bottom surface, the at least one suction device being configured to adhere the base to an adjacent surface; and
at least one release mechanism operably coupled to the at least one suction device, the at least one release mechanism being movable between a first position and a second position to apply a vertical force to an outer periphery of the at least one suction device to release the at least one suction device from the adjacent surface, wherein an exterior surface of the at least one release mechanism arranged generally flush with an outer surface of the housing in both the first position and the second position, wherein the at least one release mechanism includes a first release mechanism and a second release mechanism disposed at opposing sides of the base, respectively.

US Pat. No. 10,362,892

SYSTEM AND APPARATUS FOR REGULATING FLOW RATE IN AN ESPRESSO MACHINE

Seattle Espresso Machine ...

1. A brew flow rate regulation assembly for regulating a brew flow rate of pressurized water within an espresso machine while brewing a coffee beverage having coffee grounds using the pressurized water, comprising:an assembly body;
a brew regulation assembly input configured and arranged to allow flow of the pressurized water into the assembly body;
a brew regulation assembly output configured and arranged to allow flow of the pressurized water out of the assembly body;
a first flow path disposed in the assembly body and in fluid communication with the brew regulation assembly input and the brew regulation assembly output, wherein the first flow path is configured and arranged to receive at least a portion of the pressurized water;
a second flow path disposed in the assembly body and in fluid communication with the brew regulation assembly input and the brew regulation assembly output, wherein the second flow path is configured and arranged to receive at least another portion of the pressurized water;
a first adjustable valve configured and arranged to regulate the brew flow rate of the pressurized water within the espresso machine by restricting a first flow rate through the first flow path, the first adjustable valve configured to regulate the pressurized water to pre-wet the coffee grounds at the first flow rate within a first time interval and with a first volume of pressurized water, the combination of the first flow rate, the first time interval, and the first volume of pressurized water insufficient to extract the pressurized water through the coffee grounds to produce the coffee beverage;
a second adjustable valve configured and arranged to regulate the brew flow rate of the pressurized water within the espresso machine by restricting a second flow rate though the second flow path, the second adjustable valve configured to regulate the brew flow rate of the pressurized water to the first flow rate during pre-wetting of the coffee grounds and configured to regulate a second volume of pressurized water at a second flow rate within a second time interval to extract the pressurized water through the coffee grounds to produce the coffee beverage;
wherein the brew flow rate of the pressurized water is equal to at least a sum of the first flow rate and the second flow rate; and
controls for the brew regulation assembly configured to adjustably control the first valve and/or the second valve to vary continuously and transition between two or more positions such that the brew flow rate of the pressurized water is adjustable during the espresso brewing process to vary pressure of pressurized water along the respective first flow path and/or the second flow path, the controls for the brew regulation assembly comprising a rotatable handle or adjustment knob.

US Pat. No. 10,362,891

PRESSURE-COOKING UTENSIL PROVIDED WITH A LOCKING/UNLOCKING CONTROL MEMBER THAT OPERATES ASYMMETRICALLY

SEB S.A, Ecully (FR)

1. A food-cooking utensil comprising:a vessel and a lid;
locking/unlocking means mounted to move between a locked position in which the locking/unlocking means lock the lid to the vessel and an unlocked position in which the lid is free relative to the vessel; and
a control member for controlling the movement of the locking/unlocking means, the control member being mounted to enable a user to move the control member back and forth between (i) a locking position, which causes the locking/unlocking means to move to the locked position in which the locking/unlocking means lock the lid to the vessel, and (ii) an unlocking position, which causes the locking/unlocking means to move to the unlocked position in which the lid is free relative to the vessel, the unlocking position of the control member being a stable position in which the control member remains in the stable position without the user interacting with the control member and until force is applied manually to move the control member out of said stable position,
wherein while the control member is being moved from its locking position towards its unlocking position, the control member and the locking/unlocking means co-operate so that the instantaneous position of the locking/unlocking means varies as a function of the instantaneous position of the control member in a first relationship,
wherein while the control member is being moved from its unlocking position towards its locking position, the control member and the locking/unlocking means co-operate so that the instantaneous position of the locking/unlocking means varies as a function of the instantaneous position of the control member in a second relationship that is different from the first relationship, and
wherein in the second relationship in which the control member is being moved from its unlocking position towards its locking position, the locking/unlocking means remains stationary in its unlocked position until the control member reaches its locking position and, upon the control member reaching its locking position from its unlocking position, the control member causes the locking/unlocking means to move into its locked position from its stationary unlocked position to lock the lid to the vessel.

US Pat. No. 10,362,884

CHILD-RESTRAINING HARNESS AND BIB

1. A safety harness comprising: a body harness and a bib; wherein the safety harness is further configured for use with a person; wherein the person is selected from the group consisting of an infant and a toddler; wherein the person is further defined with a pelvis; wherein the safety harness is configured for use with a chair; wherein the body harness attaches the person to the chair; wherein the bib is a protective garment; wherein the body harness comprises a pelvic strap, a plurality of harness straps, and a plurality of harness fasteners; wherein the plurality of harness fasteners attach to the plurality of harness straps; wherein the plurality of harness straps attach to the pelvic strap; wherein the plurality of harness fasteners comprises a first hook and loop fastener and a second hook and loop fastener; wherein the first hook and loop fastener is a hook and loop fastening device; wherein the first hook and loop fastener is further defined with a first hook/loop surface and a second hook/loop surface; wherein the second hook and loop fastener is a hook and loop fastening device; wherein the second hook and loop fastener is further defined with a third hook/loop surface and a fourth hook/loop surface; wherein the first hook and loop fastener attaches the first strap to the second strap; wherein the first hook/loop surface attaches to the second hook/loop surface to form the first hook and loop fastener; wherein the safety harness is assembled using a first seam, a second seam, a third seam, and a fourth seam; wherein the first seam attaches the second end of the first strap to the superior end of the pelvic strap such that the first strap lays flush with a fifteenth end of the pelvic strap; wherein the second seam attaches a third end of the second strap to the inferior end of the pelvic strap such that the second strap lays flush with the fifteenth end of the pelvic strap; wherein the third seam attaches a sixth end of the third strap to the superior end of the pelvic strap such that the third strap lays flush with a sixteenth end of the pelvic strap; wherein the fourth seam attaches a seventh end of the fourth strap to the inferior end of the pelvic strap such that the fourth strap lays flush with the sixteenth end of the pelvic strap.

US Pat. No. 10,362,880

ASSEMBLABLE MATTRESS SUPPORT WHOSE COMPONENTS FIT INSIDE THE HEADBOARD

Zinus Inc., Tracy, CA (U...

1. An apparatus comprising:a longitudinal bar having a total length, wherein the longitudinal bar comprises an upper portion and a lower portion, wherein the upper portion has a first connector and the lower portion has a second connector; and
a headboard with a compartment and an attachment location for the first connector, wherein the attachment location for the first connector is disposed on the headboard outside the compartment, wherein the compartment has a maximum dimension that is shorter than the total length of the longitudinal bar, wherein the compartment accommodates the longitudinal bar, and wherein the first connector is configured to attach directly to the headboard when the upper portion of the longitudinal bar is outside the compartment.

US Pat. No. 10,362,878

FOLDABLE SOFA-BED

Ultra-Mek, Inc., Denton,...

1. A seating unit that includes a foldable bed, the seating unit comprising:a base with an internal cavity;
a foldable bed that includes separate and distinct head, intermediate and seat sections, wherein in a folded position, the intermediate and seat sections are generally horizontally disposed and positioned in vertically stacked relationship, and the head section is generally vertically disposed and positioned adjacent a rear portion of the base, with an outer surface of a cushion of the head section facing rearwardly to form a rear surface of the seating unit, and in an unfolded position, the head, intermediate and seat sections are generally horizontally disposed and in serial alignment with each other, with the outer surface of the cushion of the head section facing upwardly; and
a bed folding mechanism that is attached to the base and the head, intermediate and seat sections that controls the movement of the bed between the folded and unfolded positions.

US Pat. No. 10,362,877

CUSHION WITH SUPPORTING FRAME FOR UPHOLSTERED FURNITURE

EDRA S.P.A., Perignano d...

1. A cushion for upholstered furniture for leaning or sitting such as beds, sofas or armchairs, including a cushion element, constituted by an upholstery of soft material stuffed in a flabby covering, the cushion element being configured so that two opposite main sides are defined that are peripherally joined by connection sides, comprising:an elongated fixed frame arranged so as to define in the cushion element an upper section located above the fixed frame;
at least two movable frames housed within the same cushion element in correspondence of the upper section, with each of the movable frames being hinged, independently from the other, to the fixed frame according to at least one hinge axis substantially parallel to a direction of elongation of the fixed frame, and arranged to take different positions, each of which is provided to determine a desired orientation of at least one portion of the upper section of the cushion element;
movement control means associated with the hinge axes, adapted to determine an amount of deformation action needed to rotate the at least one movable frame, so as to maintain a stable position when a deformation action is applied that is lower than a certain predetermined amount; and
connecting members for connecting the cushion element to an external structure;
wherein the fixed frame extends horizontally at a vertically intermediate level of the cushion element so as to define a lower section of the cushion element located below the fixed frame, the lower section being devoid of rigid frame elements.

US Pat. No. 10,362,871

DEVICE AND METHOD FOR FIXING A PUSH ELEMENT

1. A device for fixing a push element to a rail (5) of a pull-out guide (3), comprising:a clamping mechanism with a receptacle (20);
a holding part (12) securable in the receptacle,
a device for depth adjustment for the push element (4), and
a self-locking clamping element (25) provided on the receptacle (20), by means of which the holding part (12) is frictionally secured against being pulled out,
wherein the device (11) for depth adjustment has a stop (100) which can be adjusted on or in the receptacle (20).

US Pat. No. 10,362,862

RAILING SUPPORTED BUFFET

1. A rail-mounted buffet mountable to a railing having a top rail and one or more vertical balusters, the rail-mounted buffet comprising:a main bar buffet section having a flat surface area for supporting items on the main bar buffet section;
a U-shaped channel located on an underside of the main bar buffet formed between a back-side member and a front side member, wherein the back-side member and front side member are movable in relation to one another such that a width of the U-shaped channel is adjustable, and wherein a position of the front side member relative to the backside member may be fixed in varying locations such that a width of the U-shaped channel is adjustably fixed;
a trust support having a first end and a second end, the trust support attached to the underside of the main bar buffet at the first end of the trust support;
a baluster support comprising a clamshell formed of a first clam shell portion engaged with a second clam shell such that the baluster support fits around one of the one or more balusters, the baluster support attached to the second end of the trust support.

US Pat. No. 10,362,860

FLAT PACK END TABLE AND COFFEE TABLE

Zinus Inc., Tracy, CA (U...

1. A table comprising:a first straight bar, wherein the first straight bar has a width A and a length B;
a second straight bar having the width A and the length B;
a first U-shaped bar having the width A and a distance C between ends of the first U-shaped bar, and wherein C equals A plus B;
a second U-shaped bar having the width A and the distance C between ends of the second U-shaped bar; and
a rectangular table top having shorter sides each with the length B and longer sides each with a length D, wherein D equals C plus two times A, wherein in an assembled state the ends of the first U-shaped bar are connected to opposite ends of one of the longer sides of the rectangular table top, and the ends of the second U-shaped bar are connected to opposite ends of the other of the longer sides of the rectangular table top, wherein in a compact state the rectangular table top is disposed between the ends of the first U-shaped bar, and one of the ends of the second U-shaped bar is disposed between the rectangular table top and one of the ends of the first U-shaped bar, and wherein the ends of the first U-shaped bar and the ends of the second U-shaped bar extend in opposite directions.

US Pat. No. 10,362,858

METHOD OF MANUFACTURING A BRUSH AND BRUSH

BRAUN GMBH, Kronberg (DE...

1. A method of manufacturing a toothbrush, comprising the steps of:providing a carrier having at least a first through hole extending from a front side to a backside of the carrier and at least a first wall element being integral with the carrier and extending from the backside in a vicinity of the first through hole;
introducing a first cleaning element into the first through hole such that an end portion of the first cleaning element is exposed on the backside of the carrier;
treating the end portion of the first cleaning element such that it deforms and becomes wider than the first through hole; and thereafter
deforming the first wall element until it at least partially extends over the deformed end portion of the first cleaning element such that the first cleaning element is effectively retained in its axial position, wherein the step of deforming the first wall element is performed after the step of treating the end portion of the first cleaning element.

US Pat. No. 10,362,856

CARRYING CASE FOR POLICE OR MILITARY EQUIPMENT

Armament Systems and Proc...

1. An apparatus comprisingan elongated backer plate having a plurality of mutually parallel slots spaced-apart along a longitude of the backer plate from a midpoint towards one of the ends, each extending across the backer plate transverse to the longitudinal axis and having a constant cross section in longitude with a root end relatively wider than an opposing, open end;
an elongated cover plate;
a hinge that pivotally connects a first end of the backer plate to a first end of the cover plate;
a resilient lock that releasably connects a second end of the backer plate to the second end of the cover plate;
an adjustable spacer located between the backer plate and cover plate, the adjustable spacer having a slot engaging portion extending from the adjustable spacer that is complementary to the cross section of each of the plurality of slots wherein a space between the backer plate, the cover plate, the hinge and resilient lock is adapted to accept a range of different sizes of belts worn by a human user and wherein the adjustable spacer may be inserted into any of the plurality of slots to accommodate the different sizes of belts; and
a police or military holster fabricated from a flexible fabric, the holster further including an adapter plate rotatably attached to the backer plate and a diaphragm disposed between the adapter plate and mounting plate and sewn to the flexible fabric of the holster around a periphery of the adapter plate.

US Pat. No. 10,362,847

LENS FOR PROTECTIVE CASE

Otter Products, LLC, For...

1. A protective case for an electronic device having a camera and a microphone, the protective case including a lens assembly comprising:a transparent lens having a first side configured to face the electronic device and at least partially cover the camera when the electronic device is installed in the protective case and a second side opposite the first side; wherein a first portion of the first side and a second portion of the second side are each coated with a light-blocking material and a first optically transparent portion of the first side and a second optically transparent portion of the second side are uncoated; the second optically transparent portion having an area greater than an area of the first optically transparent portion; and
a water-resistant membrane attached to the transparent lens and configured to cover the microphone of the installed electronic device.

US Pat. No. 10,362,840

DEPLOYABLE FLAG BRACELET

1. A deployable flag bracelet comprising:a medial longitudinal flap member having a first longitudinal edge, an opposing longitudinal edge, a medial flap member obverse surface, and a medial flap member reverse surface;
a first longitudinal flap member coextensive along the opposing longitudinal edge, said first longitudinal flap member having a first flap member obverse surface, and a first flap member reverse surface;
a deployable flag portion coextensive along the first longitudinal edge, said flag portion rollable for storage when not in use by rolling the flag portion into contact overlying the medial flap member obverse surface, where the flag portion is thereat concealable beneath the first longitudinal flap member by folding the first longitudinal flap member on top of the flag portion such that the first flap member obverse surface makes contact with and conceals the rolled flag portion, wherein a transverse length of the first longitudinal flap member is of sufficient length to conceal the entirety of the rolled flag portion; and
wherein said medial longitudinal flap member further has a first transverse edge and an opposing transverse edge for endwise attachment therebetween to form the bracelet wherein the deployable flag portion is maintainably concealed behind the first longitudinal flap member and wearable about a wrist of a user, whereby the user can deploy the flag portion to clean an optical surface by detaching the first transverse edge from the opposing transverse edge and unrolling the deployable flag portion.

US Pat. No. 10,362,836

REEL BASED CLOSURE SYSTEM

Boa Technology Inc., Den...

1. A closure system for tightening an article, the closure system comprising:a base member having an inner cavity and an outer peripheral wall that surrounds the inner cavity, the base member also having a first end and a second end;
a housing member that is releasably mounted within the inner cavity of the base member, the housing member having a first end that is aligned with the first end of the base member and a second end that is aligned with the second end of the base member;
a spool rotatably positioned within an interior of the housing member, the spool being rotatable in a first direction to wind a tension member about the spool and the spool being rotatable in a second direction to unwind the tension member from about the spool; and
a knob member that is rotatably coupled with the housing member and that is operationally coupled with the spool so that rotation of the knob member causes the spool to rotate in the first direction;
wherein the first end of the base member includes a recessed channel near a bottom surface thereof and the second end of the base member includes a tab member near a top surface thereof;
wherein the first end of the housing member includes a first extending tab member near a bottom surface thereof and the second end of the housing member includes a second extending tab that extends from near the bottom surface of the housing member in a direction opposite the first extending tab; and
wherein the housing member and the base member are coupleable to form a singular assembly.

US Pat. No. 10,362,834

HYDROGEL CONNECTION

Nike, Inc., Beaverton, O...

1. An article of manufacture comprising: a substrate body having a first side; a hydrogel-containing material secured to the first side such that a portion of the hydrogel-containing material is embedded into the substrate body, the hydrogel-containing material defining at least a portion of a first external surface of the article, wherein the substrate body comprises one or more traction elements extending from the first side such that the embedded portion of the hydrogel-containing material is embedded into the one or more traction elements.

US Pat. No. 10,362,833

BLADDER ELEMENT FORMED FROM THREE SHEETS AND METHOD OF MANUFACTURING A BLADDER ELEMENT

NIKE, Inc., Beaverton, O...

1. A method of manufacturing a bladder element comprising:forming at least one of a first polymeric sheet, a second polymeric sheet, or a third polymeric sheet with a contoured surface profile;
after said forming, stacking the first polymeric sheet, the second polymeric sheet, and the third polymeric sheet in a mold assembly so that the second polymeric sheet is between the first polymeric sheet and the third polymeric sheet; and
applying fluid pressure in the mold assembly:
between the second polymeric sheet and the third polymeric sheet, forcing a first surface of the second polymeric sheet into contact with an inner surface of the first polymeric sheet, or
between the first polymeric sheet and second polymeric sheet, forcing a second surface of the second polymeric sheet into contact with an inner surface of the third polymeric sheet, or
between the first polymeric sheet and second polymeric sheet, and between the second polymeric sheet and the third polymeric sheet, forcing both the second surface of the second polymeric sheet into contact with the inner surface of the third polymeric sheet, and the first surface of the second polymeric sheet into contact with the inner surface of the first polymeric sheet.

US Pat. No. 10,362,831

CYCLING SHOE

SELLE ROYAL S.P.A., Pozz...

1. A cycling shoe, comprising a sole provided with an upper face and a lower face, as well as an upper that rises up from said sole, wherein the surface of said upper comprises a plurality of recesses suitable for decreasing the form drag of said upper hit by air, wherein said sole comprises a heelpiece comprising a channeling, for conveying the air that hits the shoe through a predetermined path, in order to reduce the form drag, wherein said channeling comprises a first branch and a second branch which are not open at the upper face of the sole and which are open, respectively, at a first air inlet opening and at a second air inlet opening provided for in the lower face of the sole and on the opposite sides of the heelpiece, and wherein the first branch and the second branch communicate with a single rear discharge of the heelpiece, and wherein the heelpiece does not project with respect to the lower face of the sole, so as to define a continuous surface alongside the lower face of the sole.

US Pat. No. 10,362,817

MULTI-USE GARMENT

1. A multi-use garment comprising:a torsal portion configured to be worn over a torso having a bottom edge configured to be adjacent a waist of a wearer when worn;
a pair of sleeve portions attached to the torsal portion, wherein each sleeve portion is configured to accommodate at least a part of an arm;
a pair of separate leg portions attached to the torsal portion, wherein each leg portion is configured to accommodate at least a part of a leg, wherein each leg portion has a first end adjacent the torsal portion and a second end remote from the torsal portion;
a pair of fasteners attached to the second end of each of the pair of leg portions,
wherein each fastener is configured to create a completely closed bottom edge of the torsal portion;
wherein each fastener of the pair of fasteners is at least one of the following: a zipper, a snap button fastener, a hook and loop fastener, a drawstring, a pair of drawstrings; and
wherein each fastener of the pair of fasteners is configured to create a completely closed bottom edge of the torsal portion so that, in one configuration of the multi-use garment, each leg portion is entirely drawn into an inner space of the torsal portion thus closing off the entire bottom edge of the multi-use garment wherein nothing projects from the bottom edge of the multi-use garment and the multi-use garment is capable of being used as a storage bag or a sleeping bag.

US Pat. No. 10,362,814

PANTS CONFIGURED FOR ENHANCING WORKER MOBILITY

VF IMAGEWEAR, INC., Nash...

1. A pant configured for enhanced mobility, comprising:a first leg portion and a second leg portion, each of the first leg portion and the second leg portion comprising a front panel and a rear panel;
at least one stretch panel located on the rear panel of the first leg portion; and
at least one stretch panel located on the rear panel of the second leg portion;
in which the rear panels of the first leg portion and second leg portion are each divided into an upper region and a lower region by a substantially diagonal seam, the substantially diagonal seam extending from a point at a rear seam of the pant downward to a point at the outer seam of the leg portion;
in which an upper edge of each of the first and second stretch panels coincides with each of the substantially diagonal seams and extends from the point at the rear seam of the pant downward to an outer point located on the rear panel of the leg portion; and
in which each of the stretch panels provides a wearer with enhanced mobility when performing one or more of the following motions: (a) bending over, (b) squatting, (c) kneeling and twisting, (d) reaching forward and up, and (e) big step.

US Pat. No. 10,362,803

ELECTRONIC VAPORIZER HAVING REDUCED PARTICLE SIZE

EVOLV, LLC, Ashtabula, O...

1. An electronic vaporizer device for simulating smoking, the device comprising:at least one aerosol generating structure, comprised of:
a first heating element;
a wick configured to supply a liquid to the first heating element, the first heating element aerosolizing the liquid into an aerosol;
an air channel configured to carry the aerosol generated at the first heating element away from the first heating element;
at least one second heating structure comprised of:
a second heating element;
the second heating element being downstream relative to the first heating element to apply heat to the aerosol,
wherein the at least one second heating structure does not receive the liquid from the wick;
a connector; and
a controller that is to be removably coupled to, and separable from the aerosol generating structure by the connector, the controller being further connected to a power source providing electrical power, the controller having at least two regulated outputs which can supply the electrical power to the first heating element and the second heating element concurrently with independent control of each output, wherein the controller independently controls at least the output that supplies electrical power to the second heating element based on one or more relationships between a measured resistance of the second heating element during operation, and a known resistance of the second heating element at one or more specific temperatures;
wherein the at least one aerosol generating structure forms the aerosol having a particle size distribution in a controllable manner; and wherein the at least one second heating structure is downstream of the first heating element, the second heating element applying additional heat to the aerosol to at least change the particle size distribution within the aerosol to generate an output aerosol in a controllable manner.

US Pat. No. 10,362,799

DEVICE FOR SEPARATING STALKS OF FRUITS GROUPED IN BUNCHES AND METHOD FOR SEPARATING STALKS OF FRUITS GROUPED IN BUNCHES

RODA IBERICA, S.L., Alzi...

1. A device for separating stalks of fruits grouped in bunches, the device comprising:a fruit reception compartment, where the fruits and a liquid are configured to be located, the fruit reception compartment being connected to a fruit suction area and a liquid suction area, the liquid suction area comprising an orifice connected to a pump for suction of at least a part of the liquid,
a narrowing comprising an outlet which feeds into a channel, and
a pipe configured to carry the at least the part of the liquid from the pump into the channel,
wherein the device is configured to:
produce a depression for dragging the fruits and the liquid located in the fruit suction area through the narrowing to the channel
such that the fruits and the liquid mix with the at least the part of the liquid flowing at a first speed from the pump, and a mixture of the at least the part of the liquid flowing at the first speed from the pump and the liquid flowing at a second speed from the fruit suction area generates turbulence that produces separation of the stalks from the fruits, and
wherein the first speed is higher than the second speed.

US Pat. No. 10,362,793

MUNG BEAN PROTEIN COMPOSITION

FUJI OIL HOLDINGS INC., ...

1. A method of producing a mung bean protein powder composition having a measurement value according to the Folin-Denis method of 1.39% by weight or less in terms of gallic acid on a dry matter basis, the method comprising:extracting mung bean protein from the mung bean of which 90% or more of husk is removed;
heat-treating a solution comprising the mung bean protein at 120° C. to 160° C. for 2 seconds to 60 minutes; and
spray drying the heat-treated solution.

US Pat. No. 10,362,722

SOIL PROCESSING DEVICE

REDEXIM HANDEL-EN EXPLOIT...

1. A mobile soil working device comprising:a machine frame,
a drive,
at least one support arm configured to be movable up and down by the drive and pivotably supported by the machine frame,
at least one insertion tool configured to be pivotable relative to the support arm about a first pivot axis and movable in an upward direction and a downward direction by the support arm, the insertion tool adapted to be inserted into the soil and pulled from the soil,
wherein, prior to insertion into the soil, the insertion tool is configured to be disposed in an initial position under a predefined insertion angle, and is configured to carry out a pivot movement from the initial position, the pivot movement being superposed over up-and-down movement of the insertion tool, about the first pivot axis in a first pivoting direction in the soil on the basis of movement of the machine frame in a direction of travel,
at least one returning mechanism which is coupled to the machine frame at a first end and to the insertion tool at a second end, the returning mechanism having a first biasing element and a second biasing element, wherein the first biasing element is a returning element configured to move the insertion tool back into the initial position by pivoting the insertion tool in a second pivoting direction opposite the first pivoting direction after the insertion tool exits the soil,
wherein the second biasing element is an independent spring device in addition to the returning element, said spring device allowing the insertion tool to be pivoted in the second pivoting direction beyond the initial position such that the insertion tool is pivoted in the second pivoting direction beyond the initial position upon hitting a hard object in the soil.
US Pat. No. 10,363,300

FMDV AND E2 FUSION PROTEINS AND USES THEREOF

BOEHRINGER INGELHEIM ANIM...

1. A method of vaccinating a host susceptible to ovine, bovine, caprine, or swine Foot-and-Mouth Disease Virus (FMDV), or protecting or preventing the host against FMDV infection, or eliciting a protective immune response in a host, comprising at least one administration of a composition or vaccine comprising an FMDV antigen or polypeptide; wherein the FMDV antigen or polypeptide has at least 90% sequence identity to a polypeptide having the sequence as set forth in SEQ ID NO:2, 4, 6, 8, 10, 12 or 14.
US Pat. No. 10,362,789

METHOD FOR CONTROLLING PESTS

SUMITOMO CHEMICAL COMPANY...

1. A method for controlling a weed in a field of soybean, corn or cotton, comprising applying at least one PPO-inhibiting compound selected from the group consisting of sulfentrazone, saflufenacil, and fomesafen-sodium to a field before, at or after seeding with a seed of soybean, corn or cotton treated with one or more nematicides selected from the group consisting of abamectin and Bacillus firmus.
US Pat. No. 10,363,314

SPRAYABLE TOPICAL CARRIER AND COMPOSITION COMPRISING PHOSPHATIDYLCHOLINE

LIPIDOR AB, Stockholm (S...

1. Pharmaceutical or cosmetic carrier for topical administration, said carrier comprisingfrom 2%-40% by weight of phosphatidylcholine;
from 2%-25% by weight of monoglyceride;
from 2% to 30% by weight of fatty acid ester of C1-C3 alcohol; and
volatile solvent selected from the group consisting of:
ethanol; ethanol and C3-C4 alcohol; ethanol and volatile silicone oil; and ethanol, C3-C4 alcohol and volatile silicone oil.
US Pat. No. 10,363,572

METHOD FOR PRODUCING A MULTICOAT PAINT SYSTEM ON PLASTICS SUBSTRATES

BASF Coatings GmbH, Muen...

1. A method for producing a paint system on a plastics substrate, the method comprising:(1) producing a basecoat film or a plurality of directly successive basecoat films on the plastics substrate by applying an aqueous basecoat material to the substrate or directly successively applying a plurality of basecoat materials to the substrate;
(2) producing a clearcoat film directly on the basecoat film or a topmost basecoat film by applying a clearcoat material directly to the basecoat film or the topmost basecoat film; and
(3) jointly curing the basecoat film and the clearcoat film or the basecoat films and the clearcoat film,
wherein:
the aqueous basecoat material or at least one of the basecoat materials comprises at least one aqueous polyurethane-polyurea dispersion comprising polyurethane-polyurea particles;
the polyurethane-polyurea particles in the dispersion comprise anionic groups, groups which can be converted into anionic groups, or both;
the polyurethane-polyurea particles comprise, in each case in reacted form:
at least one polyurethane prepolymer containing isocyanate groups and comprising the anionic groups, the groups which can be converted into anionic groups, or both; and
at least one polyamine comprising two primary amino groups and one or two secondary amino groups;
the polyurethane prepolymer does not contain subunits formed from a monoalcohol;
the polyurethane-polyurea particles present in the dispersion have an average particle size of 40 to 2000 nm; and
a gel fraction of the polyurethane-polyurea particles present in the dispersion is at least 50%.
US Pat. No. 10,364,342

TIRE HAVING TREAD FOR LOW TEMPERATURE PERFORMANCE AND WET TRACTION

1. A pneumatic tire having a circumferential rubber tread of a rubber composition comprised of, based on parts by weight per 100 parts by weight elastomer (phr):(A) 100 parts by weight of a combination of conjugated diene-based elastomers comprised of:
(1) about 10 to about 50 phr of an organic solvent polymerization prepared high Tg styrene/butadiene elastomer having a Tg in a range of from about ?40° C. to about ?30° C. with a styrene content in a range of from about 30 to about 35 weight percent wherein said high Tg S-SBR is extended with from about 10 to about 38 parts by weight per 100 parts of said high Tg styrene/butadiene elastomer of triglyceride vegetable oil,
(2) about 10 to about 50 phr of aqueous emulsion polymerization prepared styrene/butadiene elastomer having a Tg in a range of from about ?65° C. to about ?45° C. with a styrene content in a range of from about 15 to about 30 weight percent, and
(3) about 20 to about 60 phr of cis 1,4-polybutadiene rubber having a cis 1,4-isomeric content of at least about 95 percent and having a Tg in a range of from about ?100° C. to about ?108° C.,
(B) about 50 to about 250 phr of rubber reinforcing filler comprised of a combination of precipitated silica derived from silicon dioxide based inorganic sand or from silicon dioxide containing rice husks and rubber reinforcing carbon black where said reinforcing filler is comprised of from about 2 to about 10 phr of said rubber reinforcing carbon black, wherein said precipitated silica of said reinforcing filler is comprised of at least one of:
(1) pre-hydrophobated precipitated silica comprised of precipitated silica pre-hydrophobated with an alkoxyorganomercaptosilane or bis(3-triethoxysilylpropyl) polysulfide containing an average of from about 2 about 4 connecting sulfur atoms in its polysulfidic bridge to form a composite thereof,
(2) precipitated silica having a nitrogen surface area in a range of from about 140 to about 220 m2/g together with a silica coupler having a moiety reactive with hydroxyl groups on said precipitated silica and another different moiety interactive with said diene-based elastomers, and
(3) precipitated silica having a nitrogen surface area in a range of from about 90 to about 130 m2/g together with a silica coupler having a moiety reactive with hydroxyl groups on said precipitated silica and another different moiety interactive with said diene-based elastomers,
(C) about 5 to about 45 phr of traction promoting resin comprised of at least one of terpene, coumarone indene and styrene-alphamethylstyrene resins having a softening point within a range of from about 60° C. to about 150° C.
US Pat. No. 10,367,160

LIGHT-EMITTING ELEMENT

Semiconductor Energy Labo...

1. A light-emitting element comprising:a light-emitting layer comprising a first compound, a second compound, and a guest material,
wherein the first compound and the second compound are capable of forming an exciplex, and
wherein an emission peak wavelength of the exciplex is longer than or equal to a peak wavelength of an absorption band located on the longest wavelength side of an absorption spectrum of the guest material.
US Pat. No. 10,363,322

NON-ALCOHOLIC FATTY LIVER REGULATOR 14-3-3 PROTEIN

Korea University Research...

1. A method of treating non-alcoholic fatty liver, the method comprising administering an inhibitor against a 14-3-3? gene to a subject to decrease transcriptional activity of PPAR?2,wherein the inhibitor comprises an antisense oligonucleotide, siRNA, shRNA or miRNA against the 14-3-3? gene, or a vector comprising the same.
US Pat. No. 10,364,346

ABS-BASED RESIN COMPOSITION AND METHOD ARTICLE MANUFACTURED THEREFROM

LG CHEM, LTD., Seoul (KR...

1. A method of preparing an ABS-based resin composition, the method comprising: a step of feeding (a) 22.5 to 50% by weight of a vinyl cyan compound-conjugated diene-based rubber-like polymer-aromatic vinyl compound copolymer resin, wherein (a) the vinyl cyan compound-conjugated diene-based rubber-like polymer-aromatic vinyl compound copolymer resin is prepared by graft-polymerizing 40 to 70% by weight of a conjugated diene-based rubber-like polymer having an average particle diameter of 2500 to 3500 ? with 8 to 48% by weight of an aromatic vinyl compound and 6 to 24% by weight of a vinyl cyan compound; (b) 47.5 to 75% by weight of an aromatic vinyl compound-vinyl cyan compound copolymer resin; (c) 1 to 6% by weight of a polyether ester amide resin; and (d) 1.5 to 3% by weight of an ethoxylated alkylamine-based antistatic agent into an extruder, followed by mixing and extruding in a 180 to 220° C. barrel.
US Pat. No. 10,364,361

WEATHERPROOF AQUEOUS WOOD COATINGS

AKZO NOBEL CHEMICALS INTE...

1. An aqueous coating composition comprising:an aqueous solvent,
a fatty amine quaternary having the following structure:
R1R2R3R4N+X?
 wherein R1, R2, R3, and R4 are independently chosen from saturated or unsaturated, linear or branched, substituted or unsubstituted, alkyl, aralkyl, or alkenyl groups, comprising from 1 to 30 carbon atoms, wherein at least one of R1, R2, R3, and R4 includes both a C12-C30 group and ethoxy and/or propoxy groups, wherein X? is an anion from an inorganic or organic acid, and wherein the number average molecular weight of the fatty amine quaternary is between about 100 g/mol and about 1500 g/mol, and
binder in an amount of between 40% to 90% by weight of the aqueous coating composition.
US Pat. No. 10,364,365

CURABLE COLORED INKS FOR MAKING COLORED SILICONE HYDROGEL LENSES

Novartis AG, Basel (CH)

1. An ink for making colored silicone hydrogel contact lenses, comprising at least a pigment, a polymeric dispersant, a synergist, a solvent and an actinically or thermally curable silicone-containing binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromer, wherein the synergist is selected from a group consisting of sulfonated Cu-phthalocyanine, copper phthalocyaninesulfonic acid and combinations thereof, wherein the ink is substantially free of water and has capability to be cured actinically or thermally to form a colored coat on a contact lens, wherein the ink is characterized by having a longer print life using a pad-printing system by at least 30% comparing to the ink which has the same composition except with no polymeric dispersant, wherein ink life is a number of printed parts that can be achieved in a print cycle.
US Pat. No. 10,364,367

NON-NEWTONIAN INKJET INKS

Hewett-Packard Developmen...

1. A non-Newtonian inkjet ink, comprising:a first metal oxide nanoparticle selected from the group consisting of substantially spherical or non-spherical silica particles, alumina particles, zinc oxide particles, iron oxide particles, titanium oxide particles, and combinations thereof, the first metal oxide nanoparticle having a particle size of 10 nm or less, and the first metal oxide nanoparticle present in an amount ranging from about 5% to about 15% by weight based on a total weight of the non-Newtonian inkjet ink;
a second metal oxide nanoparticle selected from the group consisting of alumina, titanium oxide, substantially spherical silica, anisotropic silica, and combinations thereof, the second metal oxide nanoparticle having at least one dimension greater than 10 nm, and the second metal oxide nanoparticle present in an amount ranging from 0.25% to 10% by weight based on the total weight of the non-Newtonian inkjet ink;
a colorant in an amount ranging from about 0.5% to about 10% by weight based on the total weight of the non-Newtonian inkjet ink;
an organic solvent in an amount ranging from about 5% to about 50% by weight based on the total weight of the non-Newtonian inkjet ink; and
a balance of water.
US Pat. No. 10,364,377

ADHESIVE COMPOSITIONS MADE FROM PROPYLENE-BASED POLYMERS AND CRYSTALLINE C2/C3 HOMOPOLYMER

ExxonMobil Chemical Paten...

1. An adhesive composition comprising:a polymer blend comprising a first propylene-based polymer, wherein the first propylene-based polymer is a homopolymer of propylene or a copolymer of propylene and ethylene or a C4 to C10 alpha-olefin, and a second propylene-based polymer, wherein the second propylene-based polymer is a homopolymer of propylene or a copolymer of propylene and ethylene or a C4 to C10 alpha-olefin; wherein the second propylene-based polymer is different than the first propylene-based polymer; wherein the polymer blend has a melt viscosity, measured at 190° C. and determined according to ASTM D-3236, of about 1,000 cP to about 5,000 cP;
a propylene polymer, wherein the propylene polymer is a homopolymer of propylene or a copolymer of propylene units with from about 0.5 to about 4 wt. % ethylene of C4 to C10 alpha-olefin comonomer derived units, and wherein the propylene polymer has a melt flow rate, measured according to ASTM D-1238 at 230° C. and 2.16 kg. of less than about 1,000 g/10 min; and
wherein the adhesive composition is substantially free of a functionalized polyolefin, wherein the functionalized polyolefin is selected from at least one of a maleic anhydride-modified polypropylene and a maleic anhydride-modified polypropylene wax.
US Pat. No. 10,364,378

POLARIZING STRUCTURE COMPRISING A GLYOXAL ADHESIVE SYSTEM AND POLARIZED LENS COMPRISING IT

ESSILOR INTERNATIONAL, C...

1. A polarizing structure comprising:a polarizing film having faces; and
a protective film provided on both faces of the polarizing film with an adhesive layer;
wherein the adhesive layer is a glyoxal-based adhesive obtained from a glyoxal water solution comprising:
about 5% by weight of glyoxal; and
about 5% by weight of polyvinyl alcohol (PVOH) polymer
at least one of the protective films comprises PC or PMMA; and
wherein a first face of the at least one protective film is oriented towards the polarizing film and further comprises an adhesion primer structure.
US Pat. No. 10,367,204

ALUMINUM ALLOY FOIL FOR ELECTRODE CURRENT COLLECTORS AND MANUFACTURING METHOD THEREOF

UACJ Corporation, Tokyo ...

1. An aluminum alloy foil for an electrode current collector, comprising 0.03 to 0.1 mass % (hereinafter, “mass %” is simply referred to as “%”) of Fe, 0.01 to 0.1% of Si, and 0.0001 to 0.01% of Cu, with the rest being Al and unavoidable impurities, wherein the aluminum alloy foil after final cold rolling has a tensile strength of 180 MPa or higher, a 0.2% yield strength of 160 MPa or higher, and an electrical conductivity of 60% IACS or higher; and the aluminum alloy foil has a tensile strength of 170 MPa or higher and a 0.2% yield strength of 150 MPa or higher even after the aluminum alloy foil is subjected to heat treatment at any of 120° C. for 24 hours, 140° C. for 3 hours, and 160° C. for 15 minutes.
US Pat. No. 10,364,405

TRANSPARENT SOLID DETERGENT

AJINOMOTO CO., INC., Tok...

1. A transparent solid detergent, comprising:(A) at least one N-acyl glutamic acid salt, wherein said at least one N-acyl glutamic acid salt comprises N-lauroylglutamic acid salt, myristoylglutamic acid salt, and cocoylglutamic acid salt;
(B) at least one acylglycine salt, wherein said at least one acylglycine salt comprises cocoylglycine salt;
(C) at least one polyvalent alcohol, wherein said at least one polyvalent alcohol comprises glycerol; and
(D) at least one lower alcohol,
wherein
said (A) at least one N-acyl glutamic acid salt is present in an amount of 35 to 45 parts by weight per 1 part by weight of said (B) at least one acylglycine salt;
said (C) at least one polyvalent alcohol is present in an amount of 11 to 24 parts by weight, per 1 part by weight of said (B) at least one acylglycine salt, and said (D) at least one lower alcohol is present in an amount of 2.5 to 30 parts by weight per 1 part of said (B) at least one acylglycine salt.
US Pat. No. 10,364,421

MODIFIED GLUCOAMYLASE ENZYMES AND YEAST STRAINS HAVING ENHANCED BIOPRODUCT PRODUCTION

CARGILL, INCORPORATED, W...

1. A polypeptide comprising (a) a secretion signal amino acid sequence having 90% or greater identity to SEQ ID NO:10 or SEQ ID NO:11 and (b) a glucoamylase amino acid sequence from a yeast, fungal, or bacterial glucoamylase polypeptide, wherein the polypeptide has glucoamylase activity, andwherein the polypeptide comprises SEQ ID NO: 13.
US Pat. No. 10,364,424

FACTOR X MUTANTS

LABORATOIRE FRANCAIS DU F...

1. A protein, comprising:a mutated sequence of SEQ ID No. 1, said mutated sequence of SEQ ID No. 1 comprising mutation B wherein: mutation B consists of insertion of DFLAEGLTPR (SEQ ID NO: 159) between amino acids 52 and 53 of SEQ ID No. 1.
US Pat. No. 10,364,425

RECOMBINANT OR TRANSGENIC FACTOR VII COMPOSITION, EACH FACTOR VII MOLECULE HAVING TWO N-GLYCOSYLATION SITES WITH DEFINED GLYCAN UNITS

LABORATOIRE FRANCAIS DU F...

1. A composition comprising recombinant Factor VII (FVII), produced by a transgenic female rabbit,wherein each molecule of FVII of the composition exhibits glycan moieties and two N-glycosylation sites,
wherein among all the molecules of FVII of the composition, the proportion of Gal?1,3Gal glycan moieties is between 0 and 4%,
wherein the molecules of FVII of the composition do not comprise sialic acid bound in ?2-3 links,
wherein among all the glycan moieties bound to N-glycosylation sites of the FVII of the composition, more than 50% of the glycan moieties are biantennary, monosialylated, glycan moieties,
wherein the molecules of FVII of the composition exhibit two O-glycosylation sites at position Ser52 and Ser60
wherein the molecules of FVII of the composition exhibit nine ?-carboxylated N-terminal glutamic acids, and
wherein the molecules of FVII of the composition exhibit 12 specific disulfide bridges.
US Pat. No. 10,364,431

COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY

Sarepta Therapeutics, Inc...

1. A method for treating Duchenne muscular dystrophy (DMD) in a patient in need thereof who has a mutation of the DMD gene that is amenable to exon 51 skipping, comprising intravenously administering to the patient a composition comprising eteplirsen, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, wherein eteplirsen, or a pharmaceutically acceptable salt thereof, is administered at a dose of about 30 mg/kg once a week for more than 120 weeks, such that disease progression in the patient is delayed, thereby treating the patient.
US Pat. No. 10,364,433

MODULATION OF AGPAT5 EXPRESSION

The Regents of the Univer...

1. A method of reducing insulin, glucose, and/or free fatty acid levels in blood, triglyceride levels in the liver and/or the ratio of fat to body weight of an animal comprising administering a compound comprising an antisense oligonucleotide targeted to nucleic acid encoding human AGPAT5 wherein the level of insulin, glucose and/or free fatty acid in the blood, the level of triglycerides in the liver and/or the ratio of fat to body weight of the animal is/are reduced.
US Pat. No. 10,364,184

MANUFACTURING METHOD OF BIG-MODEL LOW-PERMEABILITY MICROCRACK CORE

SOUTHWEST PETROLEUM UNIVE...

1. A manufacturing method of a big-model low-permeability microcrack core, comprising the following steps successively:(1) determining a size of a microcrack core to be manufactured;
(2) placing a plurality of stones in a baking oven to bake for 24 h under 120° C., after baking, placing the plurality of stones into a mixer, mixing and spraying an oil, and keeping the mixture of the plurality of stones and the oil for 2 h after mixing evenly to enable the oil to seep into the plurality of stones and evenly forming a layer of thin oil film on a surface of the plurality of stones;
(3) mixing the plurality of stones sprayed by the oil in step (2) with a quartz sand and a cement, and then adding water and mixing evenly to obtain a cement paste;
(4) spreading a butter on an inner surface of a core mould to form a layer of thin butter film on the inner surface of the core mould, pouring the cement paste in step (3) into the core mould, and vibrating the cement paste in the core mould by a vibrating rod during pouring to obtain a cement sample;
(5) loading a predetermined confining pressure outside the core according to a degree of porosity of the mould and the permeability after pouring, so as to adjust a pore permeability value; and
(6) forming the big-model low-permeability microcrack core after drying the cement sample.
US Pat. No. 10,364,443

PRODUCTION OF MEVALONATE, ISOPRENE, AND ISOPRENOIDS USING GENES ENCODING POLYPEPTIDES HAVING THIOLASE, HMG-COA SYNTHASE AND HMG-COA REDUCTASE ENZYMATIC ACTIVITIES

Danisco US Inc., Palo Al...

1. Recombinant cells with increased production of mevalonate, the cells comprising one or more heterologous nucleic acids comprising a mevalonate E (mvaE) gene and a mevalonate S (mvaS) gene selected from the organisms Listeria grayi (L. grayi), Enterococcus faecium (E. faecium), Enterococcus gallinarum (E. gallinarum), and Enterococcus casseliflavus (E. casseliflavus),wherein the mvaE gene and mvaS gene encode polypeptides having thiolase, HMG-CoA synthase, and HMG-CoA reductase catalytic activities, and wherein the cells produce increased amounts of mevalonate compared to mevalonate-producing cells that (A) contain an mvaE gene and mvaS gene from Enterococcus faecalis (E. faecalis) and (B) do not contain said mvaE gene and mvaS gene from E. gallinarum, E. casseliflavus, E. faecium, or L. grayi.
US Pat. No. 10,365,213

RELIABLE FLUORESCENCE CORRECTION METHOD FOR TWO-COLOR MEASUREMENT FLUORESCENCE SYSTEM

CapitalBio Corporation, ...

1. A microarray chip for use in a two-color fluorescence measurement system, comprising three kinds of standard spots separate from each other on the microarray chip that are useful for determining correction factors for fluorescence measurements with the system, wherein the three standard spots comprise:standard spot 1 comprising the donor fluorophore and none of the acceptor fluorophore used in the two-color fluorescence measurement system, wherein the donor fluorophore is immobilized on the microarray chip,
standard spot 2 comprising the acceptor fluorophore and none of the donor fluorophore used in the two-color fluorescence measurement system, wherein the acceptor fluorophore is immobilized on the microarray chip,
wherein the acceptor fluorophore in standard spot 2 is present in the same molar amount as the donor fluorophore in standard spot 1, and
standard spot 3 comprising both the donor and the acceptor fluorophores immobilized on the microarray chip, wherein the molar amount of the donor fluorophore in standard spot 3 equals the molar amount of the acceptor fluorophore in standard spot 3.
US Pat. No. 10,364,447

PRODUCTION OF OMEGA-3 FATTY ACIDS BY MYXOBACTERIA

Universitat Des Saarlande...

1. A method for the production of omega-3 polyunsaturated fatty acids which comprises:(a) preparing a vegetative inoculum of cells of an Aetherobacter strain that produces one or more omega-3 polyunsaturated fatty acids, wherein the Aetherobacter strain has a 16s rDNA sequence that is at least 97% identical to the 16s rDNA sequence set forth in SEQ ID NO: 1, 2 or 4;
(b) transferring the inoculum of step (a) to an aqueous nutrient medium and culturing the cells of said Aetherobacter strain under submerged aerobic conditions; and
(c) isolating one or more omega-3 polyunsaturated fatty acids from the cells cultured in step (b), wherein isolating comprises the steps of drying the cells, extracting the dried cells and purifying the one or more omega-3 polyunsaturated fatty acids.
US Pat. No. 10,362,922

ADSORPTION OF PARTICLES ON A MATERIAL CONTAINING A SILICONE POLYMER

Wacker Chemie AG, Munich...

1. A method for adsorption of particles by triboelectric charging, comprising adsorbing the particles on a material M which comprises an organic polymer material with silicone polymer(s) finely distributed therein, wherein the content of the silicone polymer in the material M is at least 0.0001 wt. % and less than 10 wt. % and wherein said silicon polymer comprises UHMW polysiloxane (ultra-high molecular weight silicone) having a dynamic viscosity from 1 kPa·s to 50 kPa·s at 25° C.
US Pat. No. 10,364,203

METHOD FOR PREPARING PHENOLICS USING A CATALYST

1. Method for preparing a phenolic compound comprising reacting a furanic compound with a dienophile in the presence of a catalyst comprising yttrium.
US Pat. No. 10,364,466

BIOLOGICAL MARKERS FOR IDENTIFYING PATIENTS FOR TREATMENT WITH VEGF ANTAGONISTS

Genentech, Inc., South S...

1. A method of optimizing therapeutic efficacy of a VEGF antagonist for a patient, the method comprising:(a) detecting expression of at least three genes set forth in Table 2 in a sample obtained from the patient prior to any administration of a VEGF antagonist to the patient;
(b) comparing the expression level of the at least three genes to a reference expression level of the at least three genes, wherein a change in the level of expression of the at least three genes in the patient sample relative to the reference expression level identifies a patient who is likely to respond to treatment with a VEGF antagonist; and
(c) administering a VEGF antagonist to the patient identified in step (b) as likely to respond to treatment with a VEGF antagonist,
wherein the VEGF antagonist is an anti-VEGF antibody and the change in the level of expression of the at least three genes in the patient sample is an increase relative to the reference expression level.
US Pat. No. 10,364,474

MICROBIAL MARKERS AND USES THEREFOR

IMMUNEXPRESS PTY LTD, Bo...

1. A method of treating a sepsis-associated bacterial infection in a mammalian subject, the method comprising:1) determining that a subject has an infection with a sepsis-associated Gram positive or Gram negative bacterium by detecting a single nucleotide polymorphism (SNP) in a 16S rRNA gene in nucleic acid from a blood sample from the subject, wherein the SNP is at a position corresponding to position 396 of the 16S rRNA gene set forth in SEQ ID NO:1, and wherein
the bacterium is determined to be a Gram-negative bacterium only when there is a C at position 396 and the bacterium is determined to be a Gram-positive bacterium only when there is an A, T or G at position 396; wherein the bacterium is selected from among Salmonella enterica, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Enterococcus faecalis, Enterococcus faecium, Clostridium perfringens, Streptococcus anginosus, Streptococcus constellatus, Streptococcus intermedius, Streptococcus mitis, Streptococcus mutans, Streptococcus sanguinis, Streptococcus sobrinus, Streptococcus oralis, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus bovis, Streptococcus sanguinis, Streptococcus dysgalactiae, Streptococcus mutans, Streptococcus pyogenes, Escherichia coli, Acinetobacter baumannii, Bacteroides fragilis, Burkholderia cepacia, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Enterobacter aerogenes, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Citrobacter freundii, Morganella morganii, Haemophilus influenzae, Neisseria meningitidis, Stenotrophomonas maltophila, Prevotella buccae, Prevotella intermedia, Prevotella melaninogenica, Mycobacterium tuberculosis, Streptomyces somaliensis and Streptomyces anulatus; and
2) administering to the subject a therapy when the subject is determined in step 1) to have an infection with a sepsis-associated Gram positive or Gram negative bacterium, wherein the therapy comprises administration of an antibiotic and/or an antibody to endotoxin.
US Pat. No. 10,366,782

METHOD AND SYSTEM FOR MICROBIOME-DERIVED CHARACTERIZATION, DIAGNOSTICS, AND THERAPEUTICS FOR CARDIOVASCULAR DISEASE CONDITIONS

uBiome, Inc., San Franci...

1. A method for at least one of characterizing and treating a cardiovascular condition for a subject, the method comprising:providing a sampling kit to the subject associated with the cardiovascular condition, the sampling kit comprising a sample container and a pre-process reagent component, wherein the sample container is operable to receive a sample;
receiving the sample from the sampling kit, the sample comprising a microorganism component;
selecting a primer set for a nucleic acid sequence set associated with the microorganism component;
with a next generation sequencing platform, determining a set of microorganism nucleic acid sequences based on the sample and the primer set;
generating a microbiome feature dataset for the subject based on the set of microorganism nucleic acid sequences;
generating a characterization of the cardiovascular condition based on the microbiome feature dataset;
determining a therapy for the subject based on the characterization, wherein the therapy is operable to improve a state of the cardiovascular condition; and
providing the therapy to the subject associated with the cardiovascular condition, wherein the therapy is operable to modulate microbiome composition to improve the state of the cardiovascular condition.
US Pat. No. 10,364,478

BAINITE-CONTAINING-TYPE HIGH-STRENGTH HOT-ROLLED STEEL SHEET HAVING EXCELLENT ISOTROPIC WORKABILITY AND MANUFACTURING METHOD THEREOF

NIPPON STEEL CORPORATION,...

1. A bainite-containing high-strength hot-rolled steel sheet, comprising: in mass %,C: greater than 0.07 to 0.2%;
Si: 0.001 to 2.5%:
Mn: 0.01 to 4%;
P: 0.15% or less (not including 0%);
S: 0.03% or less (not including 0%);
N: 0.01% or less (not including 0%);
Al: 0.001 to 2%; and
a balance being composed of Fe and inevitable impurities, wherein an average value of pole densities of the {100}<011> to {223}<110> orientation group represented by respective crystal orientations of {100}<011>, {116}<110>, {114}<110>, {113}<110>, {112}<110>,{335}<110>, and {223}<110> at a sheet thickness center portion being a range of ? to ? in sheet thickness from the surface of the steel sheet is 4.0 or less, and a pole density of the {332}<113>crystal orientation is 4.8 or less, an average crystal grain diameter is 10 ?m or less and a Charpy fracture appearance transition temperature vTrs is ?20° C. or lower, and a microstructure is composed of 35% or less in a structural fraction of pro-eutectoid ferrite and a balance of a low-temperature transformation generating phase.
US Pat. No. 10,363,202

DENTAL MATERIAL INCLUDING PROPYLBARBITURIC ACID POLYMERIZATION CATALYST

SHOFU INC., Kyoto (JP)

1. A dental material comprising a polymerizable monomer, 1-cyclohexyl-5-propylbarbituric acid and trioctylmethylammonium chloride, wherein the polymerizable monomer comprises a (meth)acrylic acid group-containing monomer.
US Pat. No. 10,363,207

ALL-IN-ONE SKIN-BRIGHTENING FORMULATIONS

1. An all-in-one skin treatment formulation comprising a base composition of ingredients of:from 91.78 to 96% by weight of water;
from 0.0001 to 2% by weight of Kojic Acid;
from 0.05 to 0.15% by weight of Niacinamide;
from 0.8 to 1.2% by weight of Sodium Hyaluronate;
from 0.008 to 0.012% by weight of Licorice Extract; and
from 0.08 to 0.12% by weight of Tocopherol;
up to 5% by weight of a biomimetic encapsulated whitening peptide, wherein said biomimetic encapsulated whitening peptide component comprises water, butylene glycol, hydrogenated lecithin, sodium oleate, oligopeptide-68, and sodium ethylene diamine-tetraacetic acid (EDTA);
up to 0.01% by weight of Retinol;
from 0 to 1.1% by weight of preservatives;
from 0 to 2.5% of lactic acid;
from 0 to 2.5% of glycolic acid; and
from 0 to 2% by weight of Hydroquinone; wherein said biomimetic encapsulated whitening peptide and said Retinol are both present.
US Pat. No. 10,363,719

MONOAXIALLY ORIENTED MULTILAYER CAST FILM

Borealis AG, Vienna (AT)...

1. A multilayer cast film oriented in machine direction, the multilayer cast film comprises at least three layers A, B and C, whereina) layer A is an outer layer comprising a heterophasic propylene copolymer, wherein the heterophasic propylene copolymer of layer A comprises
a-a) 75 to 95 wt % of a polypropylene matrix (PP-M) with an MFR2 (ISO 1133, 230° C., 2.16 kg) of 0.5 to 30.0 g/10 min being a homopolymer or a copolymer which has a comonomer content of less than 10.0 wt %,
a-b) 5 to 25 wt % of a propylene/alpha-olefin rubber (EPR) with at least 50 wt % propylene having an intrinsic viscosity (IV) of 0.8 to 2.5 dl/g, and
a-c) 0.0001 to 1 wt % of an alpha-nucleating agent (NA);
b) layer B is a core layer comprising a high isotacticity polypropylene homopolymer, wherein the high isotacticity polypropylene homopolymer of layer B is characterized by
(b-i) an isotacticity expressed in mmmm pentads of at least 96 mol %, measured by means of 13 C-NMR,
(b-ii) a decaline soluble content of 2.0 wt % or below, and
(b-iii) polydispersity index (PI) of at least 5.5;
and
c) layer C is a sealing layer comprising a propylene based random copolymer or a propylene based terpolymer, optionally in combination with a heterophasic propylene copolymer, wherein the propylene based random copolymer or terpolymer of layer C comprises
(c-i) 80.0 to 98.0 wt % of propylene,
(c-ii) up to 5.0 wt % of ethylene, and
(c-iii) 1.5 to 20.0 wt % of an alpha-olefin having 4 to 20 carbon atoms,
wherein the sum of (c-i), (c-ii), (c-iii) is 100 wt % and the amount of ethylene (c-ii), if present, is lower than the amount of alpha-olefin (c-iii),
wherein the machine direction oriented multilayer cast film has
(i) a tensile modulus measured according to ISO 527-3 on a 50 ?m film in machine direction of at least 2600 MPa and in transverse direction of at least 1200 MPa,
(ii) a haze value measured according to ASTM D1003 on a 50 ?m film of at most 5.5%, and
(iii) a shrinkage measured according to the method as described in the experimental parton a 50 ?m film after 10 minutes at 100° C. in machine direction of at most ?3.0%.
US Pat. No. 10,364,231

METHOD FOR PRODUCING 2,3,5-TRIMETHYL BENZOQUINONE BY OXIDATION OF 2,3,6-TRIMETHYLPHENOL

BASF SE, (DE)

1. A mixture consisting essentially of 2,3,5-trimethylbenzoquinone, the mixture being prepared by a process consisting essentially of the following step:(i) oxidizing 2,3,6-trimethylphenol to 2,3,5-trimethylbenzoquinone with oxygen or an oxygen-containing gas in a two-phase or multiphase reaction medium in the presence of a catalyst or catalyst system at least comprising a copper(II) halide, to give a mixture comprising 2,3,5-trimethylbenzoquinone,wherein the reaction medium comprises water and at least one secondary aliphatic acyclic alcohol having 6 or more carbon atoms.
US Pat. No. 10,363,211

HAIR CONDITIONING COMPOSITIONS COMPRISING LOW VISCOSITY EMULSIFIED SILICONE POLYMERS

The Procter and Gamble Co...

1. A hair conditioning composition comprising:a) a silicone polymer comprising:
i. one or more quaternary groups;
ii. at least one silicone block comprising greater than 200 siloxane units;
iii. at least one polyalkylene oxide structural unit; and
iv. at least one terminal ester group;
wherein said silicone polymer has a viscosity of 500 mPa·s to 100,000 mPa·s at 20° C. at 100% concentration of said silicone polymer with no additional solvents and a shear rate of 0.1 s?1,
wherein said silicone polymer is added to create a pre-emulsified dispersion with a particle size of less than about 1 micron, and
b) a gel matrix comprising:
i. a cationic surfactant;
ii. a high melting point fatty compound, wherein the high melting point fatty compound has a melting point of about 25° C. or higher; and
iii. an aqueous carrier;
wherein said silicone polymer is mixed with said gel matrix.
US Pat. No. 10,363,212

AESCULUS HIPPOCASTANUM EXTRACT

1. A method of improving an appearance of a skin and/or a mucosa, to improve cutaneous strength and/or elasticity, to treat or prevent skin aging, wrinkles, or skin slackening, the method comprising:administering an extract for a cosmetic treatment of the skin and/or mucosa,
said extract being an Aesculus hippocastanum extract obtained by an extraction method comprising:
a solid/liquid extraction step of a flower of Aesculus hippocastanum with a solvent, followed by
a second solid/liquid separation step, and
a third step for recovering the liquid phase,
wherein the solvent consists of a mixture of fructose and glycerin and water.
US Pat. No. 10,365,262

METHOD OF MONITORING A PARAMETER OF A HYDROCARBON WELL, PIPELINE OR FORMATION

Johnson Matthey Public Li...

1. A method of monitoring a parameter of a hydrocarbon well, pipeline or formation, the method comprising:introducing a tracer into the hydrocarbon well, pipeline or formation;
producing a fluid from the hydrocarbon well, pipeline or formation; and
analysing the fluid to determine if the tracer is present in the fluid;
wherein the tracer comprises a halogenated alkoxylated-benzoic acid, an alkoxylated benzene sulfonic acid, a salt of a halogenated alkoxylated-benzoic acid, or a salt of an alkoxylated benzene sulfonic acid.
US Pat. No. 10,366,799

TRANSPARENT CONDUCTOR, METHOD FOR PREPARING THE SAME AND DISPLAY APPARATUS INCLUDING THE SAME

SAMSUNG SDI CO., LTD., Y...

1. A transparent conductor, comprising:metal nanowires; and
a matrix in which the metal nanowires are embedded,
wherein:
a capping layer is formed on surfaces of the metal nanowires, the capping layer including a sulfur-containing compound, and
the capping layer has a thickness of about 0.025 or less times an average diameter of the metal nanowires.
US Pat. No. 10,363,218

SYNTHESIS OF PROBIOTIC NANOPARTICLES

King Saud University, Ri...

1. An method of fabricating a probiotic nanoparticle, comprising:(a) dissolving a probiotic in methanol to form a first solution;
(b) spraying the first solution into boiling water at a controlled flow rate under ultrasonic conditions to form a sonicated solution; and
(c) stirring the sonicated solution to provide the probiotic nanoparticle.
US Pat. No. 10,364,246

SMALL MOLECULE INHIBITORS OF THE JAK FAMILY OF KINASES

Janssen Pharmaceutica NV,...

1. A compound selected from the group consisting of2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide;
2-((1r,4r)-4-(2-(1H-Imidazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile;
2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1-hydroxycyclopropyl)methyl)acetamide; and
pharmaceutically acceptable salts, and combinations thereof.
US Pat. No. 10,363,223

DELAYED-RELEASE ENCAPSULATION OF DEER VELVET POWDER TO PROTECT THE DEER VELVET POWDER UNTIL MICELLIZATION AND ABSORPTION WITHIN THE TERMINAL ILLIUM

1. A capsule of deer velvet powder for ensuring delivery of unaltered molecules of the deer velvet powder systemically to organs of a body, the body having a stomach and a small intestine, the small intestine having a terminal ileum, the capsule of deer velvet powder comprising:a delayed release capsule; and
a quantity of deer velvet powder contained within the delayed release capsule,
the delayed release capsule made using hydroxypropyl methylcellulose, and
the delayed release capsule configured to resist digestive processes in the stomach so as to release the quantity of deer velvet powder substantially along the small intestine, thereby ensuring micellization and absorption of various components of the deer velvet powder along the terminal ileum.
US Pat. No. 10,363,224

EXTENDED-RELEASE TOPIRAMATE CAPSULES

UPSHER-SMITH LABORATORIES...

1. A method of dosing a subject for the treatment of convulsions, the method comprising:administering an extended-release topiramate capsule once daily to the subject, wherein the extended-release topiramate capsule comprises:
a capsule shell comprising a single population of coated particles;
wherein each coated particle comprises a core and a coating thereon;
wherein each particle core comprises a homogeneous mixture comprising topiramate throughout its core; and
wherein the coating comprises one or more release controlling agent(s);
wherein the extended-release topiramate capsule, when given as a single-dose to a healthy human subject, achieves an AUC0-inf of 170 to 210 h??g/mL within a 95% confidence interval, and a Cmax of 2 to 4 ?g/mL within a 95% confidence interval.
US Pat. No. 10,364,251

POLYESTERS FROM ASSYMETRICAL MONOMERS BASED UPON BISANHYDROHEXITOLS

New Jersey Institute of T...

1. An AB monomer comprising bisanhydrohexitol derivatives capable of self-polymerization directly to form a sterioregular or regioregular condensation polymer, wherein the AB monomer has the structure:A—X—C—Y—B
wherein:
a. A is a carboxylic acid, an ester, or an acid chloride,
b. Y is a bisanhydrohexitol unit derived from isosorbide, isoidide or isomannide;
c. X is selected from the group consisting of:
i. aromatic rings, including 1,4-phenylene, 1,3-phenylene, 2,6-naphthalene, 2,7-naphthalene or substituted derivatives thereof;
ii. substituted or unsubstituted heterocycles, and
iii. saturated or unsaturated aliphatic chains;
d. B is —OH; and
e. C is an ester carbonyl link with the carbon attached to X and the oxygen attached to Y, and wherein the AB monomer is at least about 98% pure endo-substituted bisanhydrohexitol derivative or an at least about 98% pure exo-substituted bisanhydrohexitol derivative.
US Pat. No. 10,364,512

MULTIFILAMENT AND BRAID

TOYOBO CO., LTD., Osaka-...

10. A braid comprising a multifilament comprising 5 or more monofilaments, whereinthe braid shows 1000 times or more in number of reciprocating abrasions at break in an abrasion resistance test measured at a load of 5 cN/dtex in accordance with JIS L-1095, and
the multifilament contains polyethylene having an intrinsic viscosity [?] of 5.0 dL/g or more and 40.0 dL/g or less and substantially including ethylene as a repeating unit.
US Pat. No. 10,365,280

COMPOSITIONS AND METHODS FOR TREATING MALIGNANCIES

DANA-FARBER CANCER INSTIT...

1. A method for identifying a therapeutic agent for treating multiple myeloma (MM), the method comprising:(a) providing a first polypeptide comprising a CD147 polypeptide and a second polypeptide comprising an extracellular cyclophilin A (eCyPA) polypeptide sequence under conditions that allow for binding of the CD147 polypeptide and the eCyPA sequence;
(b) contacting the complex with a test agent;
(c) determining whether the test agent disrupts binding of the first and second polypeptide,wherein disruption of the binding of the first polypeptide and second polypeptide by the test agent indicates the test agent is a putative therapeutic agent for treating MM;(d) contacting the putative therapeutic agent with a multiple myeloma (MM) cell population expressing CD147; and
(e) determining whether the putative therapeutic agent inhibits migration of MM cells from the MM cell population into bone marrow,
wherein inhibition of MM cell migration indicates the test agent is a therapeutic agent for treating MM.
US Pat. No. 10,365,281

BIOMARKERS OF RAPID PROGRESSION IN ADVANCED NON-SMALL CELL LUNG CANCER

Rush University Medical C...

1. A method for measuring a panel of biomarkers in a subject suspected of having rapidly progressing lung cancer the method comprising:obtaining a biological sample from the subject;
determining whether the subject is treatment naïve or has received at least one treatment;
assaying a level of each biomarker in a first biomarker panel or a second biomarker panel in the biological sample, the first biomarker panel comprising sTNFRI, sTNFRII, CA 19-9, Follistatin, Total PSA, TNF-? and IL-6 for treatment naïve subjects and the second biomarker panel comprising TRAIL, sTNFRI, IGFBP-1, sEGFR, IGF-1, TGF-?, HGF, MMP-7, MMP-2, ?-fetoprotein, Osteopontin, sVEGFR2 and IL-6 for subjects having received at least one treatment.
US Pat. No. 10,364,514

FLUOROPOLYMER FIBRE

SOLVAY SA, Brussels (BE)...

1. A process for manufacturing one or more fluoropolymer fibres, said process comprising:contacting a liquid composition (C1) comprising:
at least one fluoropolymer comprising at least one hydroxyl end group [polymer (FOH)], and
a liquid medium comprising at least one organic solvent (S);with at least one metal compound (M) of formula (I):X4?mAYm  (I)
wherein X is a hydrocarbon group, optionally comprising one or more functional groups, m is an integer from 1 to 4, A is a metal selected from the group consisting of Si, Ti and Zr, and Y is a hydrolysable group selected from the group consisting of an alkoxy group, an acyloxy group and a hydroxyl group, thereby providing a liquid composition (C2);
submitting composition (C2) to at least partial hydrolysis and/or polycondensation, thereby providing a liquid composition (C3) comprising at least one fluoropolymer hybrid organic/inorganic composite;
processing composition (C3) by electrospinning, thereby providing one or more fluoropolymer fibres;
drying the fluoropolymer fibre(s), thereby providing one or more dried fluoropolymer fibres; and
optionally, submitting to compression the dried fluoropolymer fibre(s) at a temperature comprised between 50° C. and 300° C., thereby providing compressed fluoropolymer fibres.
US Pat. No. 10,365,282

METHOD AND BIOMARKER FOR DETECTING METASTASIS OF SARCOMA

SHANGHAI KEXIN BIOTECH CO...

1. A method for diagnosing a subject suspect of having sarcoma metastasis, the method comprising:obtaining a biological sample of the subject, wherein the biological sample is serum or plasma;
detecting a level of a N-terminal segment of moesin in the biological sample;
comparing the level of the N-terminal segment of moesin detected in the biological sample of the subject to a reference level of the N-terminal segment of moesin detected from a reference sample; and
administering to the subject a treatment for metastasis of a sarcoma when the level of the N-terminal segment of moesin detected in the biological sample is higher than the reference level.
US Pat. No. 10,363,235

COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF TREATING OR PREVENTING FIBROSIS USING SAME

Afimmune Limited, (IE)

1. A method of reducing or preventing fibrosis in a subject in need thereof, the method comprising;identifying the subject as having or as having an increased risk for developing fibrosis associated with an organ or tissue selected from the group consisting of: liver, heart, mediastinum, bone marrow, retroperitoneaum, skin, intestine, joint, and a reproductive organ, or a combination thereof; and, based on the identification,
administering to the subject a composition comprising 15-HEPE wherein the 15-HEPE represents at least 80% by weight of all fatty acids in the pharmaceutical composition.
US Pat. No. 10,365,283

ACTIVATED HER3 AS A MARKER FOR PREDICTING THERAPEUTIC EFFICACY

Daiichi Sankyo Europe Gmb...

1. A method for treating patients responsive to a target specific therapy comprising an inhibitory anti-HER3 antibody, comprising(a) obtaining at least one sample from a subject having a tumor disease, prior to treatment with an inhibitory anti-HER3 antibody, wherein the sample is a normal hair follicle biopsy,
(b) obtaining at least one sample from said subject having said tumor disease after treatment with the inhibitory anti-HER3 antibody, wherein the sample is a normal hair follicle biopsy,
(c) examining the phosphorylation level of a HER3 receptor in said samples,
(d) determining that the phosphorylation level of the HER3 receptor is reduced after treatment with the inhibitory anti-HER3 antibody as compared to the phosphorylation level of the HER3 receptor before treatment with the inhibitory anti-HER3 antibody, and
(e) administering to the subject with said tumor disease, who has been determined in step (d) to have a reduced phosphorylation level of the HER3 receptor, a therapeutically effective amount of said inhibitory anti-HER3 antibody,
wherein the tumor disease is selected from the group consisting of NSCLC, breast, colon, gastric, pancreas and prostate cancer, and
wherein said inhibitory anti-HER3 antibody is selected from the group consisting of antibody U3-1287, 105.5, SGP-1, H3 90.6, 1B4C3, and 2D1 D12.
US Pat. No. 10,363,236

ISOTHIOCYANATE FUNCTIONAL SURFACTANTS, FORMULATIONS INCORPORATING THE SAME, AND ASSOCIATED METHODS OF USE

The William M. Yarbrough ...

1. A surfactant formulation, comprising:a lysine derivative, wherein the lysine derivative comprises an ?-nitrogen and a ?-nitrogen, and wherein an alkyl and/or alkanoyl substituent comprising at least 8 carbon atoms is bound to the ?-nitrogen, and further wherein the ?-nitrogen forms part of an isothiocyanate functional group.
US Pat. No. 10,364,260

PROCESS FOR PREPARING TRIS[3-(ALKOXYSILYL)PROPYL] ISOCYANURATES

Evonik Degussa GmbH, Ess...

1. A process for preparing at least one tris[3-(alkoxysilyl)propyl] isocyanurate selected from the group consisting of tris[3-(trialkoxysilyl)propyl] isocyanurate, tris[3-(alkyldialkoxysilyl)propyl] isocyanurate and tris[3-(dialkylalkoxysilyl)propyl] isocyanurate by hydrosilylation, the process comprising:(A) initially charging a mixture comprising at least one H-silane selected from the group consisting of hydrotrialkoxysilane, hydroalkyldialkoxysilane, and hydrodialkylalkoxysilane, with at least one carboxylic acid and a Pt catalyst, and heating the mixture to a temperature of 50 to 140° C.,
(B) adding a mixture of 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione and at least one alcohol to the mixture obtained in (A) while mixing,
(C) leaving the mixture obtained in (B) to react while mixing and
(D) working up the product mixture thus obtained.
US Pat. No. 10,364,262

METHOD FOR THE SYNTHESIS OF N-PHOSPHONOMETHYLIMINODIACETIC ACID

Monsanto Technology LLC, ...

1. A method for synthesis of N-phosphonomethyliminodiacetic acid or derivatives thereof selected from the group consisting of phosphonate esters of N-phosphonomethyliminodiacetic acid, carboxylate esters of N-phosphonomethyliminodiacetic acid, phosphonate and carboxylate esters of N-phosphonomethyliminodiacetic acid, N-phosphonomethyliminodiacetic acid salts, phosphonate esters of N-phosphonomethyliminodiacetic acid salts, carboxylate esters of N-phosphonomethyliminodiacetic acid salts and phosphonate-carboxylate esters of N-phosphonomethyliminodiacetic acid salts, wherein a cation of the salt is selected from the group consisting of ammonium, isopropylammonium, ethanolammonium, dimethylammonium, trimethylsulfonium, sodium and potassium,comprising the steps of:
a) forming an anhydrous reaction mixture comprising an acid catalyst, a compound of the following general formula R1—CH2—NX—CH2—R2 and a compound having one or more P—O—P anhydride moieties, to form a compound having the general formula R1—CH2—N(—CH2PO3R32)(—CH2—R2), wherein in the compound of the formula R1—CH2—NX—CH2—R2:
X is —CH2—COOH and R1 and R2 are each independently nitrile or C1-C4 alkyl carboxylate, or R1 and R2 are both carbonyl groups linked by means of a hydrogen substituted nitrogen atom or a C1-C4-alkyl substituted nitrogen atom; or
X is —CH2—OH and R1 and R2 are each independently nitrile, C1-C4 carboxylate, or carboxylic acid, or R1 and R2 are both carbonyl groups linked by means of a hydrogen substituted nitrogen atom or a C1-C4-alkyl substituted nitrogen atom;
and wherein in the compound having the general formula R1—CH2—N(—CH2PO3R32)(—CH2—R2), R3 is H, an alkyl group; and
the P—O—P anhydride moieties comprising compound is a compound wherein at least one of the one or more P—O—P anhydride moieties comprises one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V) and is selected from the group consisting of tetraphosphorus hexaoxide, P4O7, P4O8, P4O9, pyrophosphites of general formula (RO)2P—O—P(OR)2 wherein R is an alkyl or aryl group, and combinations thereof, and
b) hydrolyzing the compound having the general formula R1—CH2—N(—CH2PO3R32)(—CH2—R2) to form N-phosphonomethyliminodiacetic acid or one of its derivatives.
US Pat. No. 10,365,288

CITRULLINATED BRAIN AND NEUROLOGICAL PROTEINS AS BIOMARKERS OF BRAIN INJURY OR NEURODEGENERATION

THE JOHNS HOPKINS UNIVERS...

1. A method for detecting citrullinated brain injury biomarker proteins in a sample from a subject having or suspected of having brain injury, the method comprising:detecting in the subject's sample citrullinated arginine residues in citrullinated brain injury biomarker protein glial fibrillary acidic protein (GFAP) and/or citrullinated brain injury biomarker protein myelin basic protein (MBP) by detecting the citrullinated arginine residues in said citrullinated biomarker proteins using a detection method selected from mass spectrometry, immunoassay, electrochemical luminescent assay, electrochemical voltametry, electrochemical amperometry, atomic force microscopy, radio frequency multipolar resonance spectroscopy, confocal microscopy, non-confocal microscopy, fluorescence optical detection, luminescence optical detection, chemiluminescence optical detection, absorbance optical detection, reflectance optical detection, transmittance optical detection, birefringence optical detection, refractive index detection, surface plasmon resonance, ellipsometry, resonant mirror detection, grating coupler waveguide detection, or interferometry; thereby detecting citrullinated brain injury biomarker proteins in the subject's sample.
US Pat. No. 10,363,242

METHODS OF INHIBITING CATARACTS AND PRESBYOPIA

UNIVERSITY OF MASSACHUSET...

1. An ophthalmic composition comprisingat least one ?-crystallin charge masking agent, wherein the at least one ?-crystallin charge masking agent is a bifunctional molecule consisting of
two different end groups selected from NH2, methyl, a succinimide, a carboxylic acid, isocyanate, an isothiocyanate, a sulfonyl chloride, an aldehyde, a carbodiimide, an acyl azide, an anhydride, a fluorobenzene, a carbonate, an N-hydroxysuccinimide ester, an imidoester, an epoxide and a fluorophenyl ester,
covalently linked to a molecular bristle that is a polyethylene glycol having 4 to 200 oxyethylene groups, an alkoxy-polyethylene glycol having 4 to 200 alkoxyethylene groups, an aryloxypolyethylene glycol having 4 to 200 aryloxyethylene groups, poly(2-hydroxypropyl)methacrylamide (HPMA), poly(2-hydroxyethyl)methacrylate (HEMA), a poly(2-oxaziline), poly(m-phosphocholine, poly lysine, or poly glutamic acid, the molecular bristle having a number average molecular weight of 150 to 8000, and
an ophthalmically acceptable excipient.
US Pat. No. 10,364,268

ION EXCHANGE MEMBRANE CHROMATOGRAPHY

Genentech, Inc., South S...

1. A method of enhancing efficiency of downstream chromatography steps for purification of antibodies consisting of:a. passing a harvested cell culture fluid composition comprising an antibody of interest and various contaminants through a cation exchange membrane, wherein the antibody and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH of about 1 to about 5 pH units below the pl of the antibody and a conductivity of ?about 40 mS/cm, which cause the membrane to bind the antibody and at least one ionic polymer contaminant, where in the ionic polymer contaminant is one or more of polyethyleneimine (PEI), polyvinylamine, polyarginine, polyvinylsulfonic acid, or polyacrylic acid;
b. overloading the cation exchange membrane to promote competitive adsorption such that at least one ionic polymer contaminant remains bound to the membrane while the antibody of interest is primarily in the effluent;
c. collecting the effluent from the cation exchange membrane comprising the antibody of interest;
d. subjecting the membrane effluent comprising the antibody of interest to a cation exchange chromatography purification step, wherein the dynamic binding capacity of the cation exchange chromatography purification step is significantly improved as a result of steps (a) through (c);
e. recovering the purified antibody from the effluent of the cation exchange chromatography purification step;
f. subjecting the cation exchange chromatography purified pool to a final polishing step; and
g. recovering the purified antibody of interest.
US Pat. No. 10,363,246

METHODS AND COMPOSITIONS FOR TREATMENT OF EPILEPTIC DISORDERS

Ovid Therapeutics Inc., ...

1. A method of treating essential tremor comprising administering to a patient in need thereof a pharmaceutical composition comprising gaboxadol or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,364,271

IMMUNOTHERAPY AGAINST SEVERAL TUMORS OF THE BLOOD, IN PARTICULAR CHRONIC LYMPHOID LEUKEMIA (CLL)

Immatics Biotechnologies ...

1. A method of eliciting an immune response in a patient who has cancer, comprising administering to said patient a population of activated T cells that selectively recognize cells, which present a peptide consisting of the amino acid sequence SEQ ID NO: 63, wherein said cancer is selected from the group consisting of chronic lymphoid leukemia (CLL), acute myelogenous leukemia (AML), adrenal gland adrenal cortical adenoma, bone giant cell tumor of bone, bone non-ossifying fibroma, breast carcinoma, colon adenocarcinoma, non-Hodgkin's lymphoma, endometrium adenocarcinoma endometrioid, kidney angiomyolipoma, kidney carcinoma, kidney oncocytoma, liver focal nodular hyperplasia, liver hepatocellular carcinoma, lymph node Hodgkin's disease, lymph node papillary carcinoma of thyroid, medullary carcinoma of thyroid origin, metastatic adenocarcinoma of stomach, neurofibroma, ovary thecoma fibroma, pancreas adenocarcinoma, pancreas microcystic adenoma, parathyroid gland adenoma, rectum adenocarcinoma, skin squamous cell carcinoma, spleen chronic myeloid leukemia, stomach gastrointestinal stromal tumor (GIST), thyroid gland nodular hyperplasia, thyroid gland papillary carcinoma, and uterine cervix squamous cell carcinoma.
US Pat. No. 10,362,741

TOMATO FRUIT HAVING INCREASED FIRMNESS

Syngenta Participations A...

1. A Solanum lycopersicum tomato fruit with significantly increased fruit firmness at the harvesting stage comprising at least one genetic element in the cultivated Solanum lycopersicum tomato plant producing said tomato fruit, wherein said firmness is measured on the inner pericarp and is from between 1.2 to 2.0 times greater than that of fruit from a control Solanum lycopersicum tomato plant which does not have the said at least one genetic element, wherein said genetic element is identical to a genetic element of Solanum lycopersicum QTL-NIL 301 deposited with NCIMB under accession number 41662, and wherein the said genetic element of QTL-NIL 301 is linked to at least one DNA marker in the cultivated Solanum lycopersicum tomato plant, said at least one DNA marker selected from:a) NT3853, which can be detected by a forward primer of SEQ ID NO: 1 and a reverse primer of SEQ ID NO: 2;
b) NT3907, which can be detected by a forward primer of SEQ ID NO: 3 and a reverse primer of SEQ ID NO: 4;
c) TG14, which can be detected by a forward primer of SEQ ID NO: 5 and a reverse primer of SEQ ID NO: 6;
d) HOX7A, which can be detected by a forward primer of SEQ ID NO: 7 and a reverse primer of SEQ ID NO: 8;
e) CT277, which can be detected by a forward primer of SEQ ID NO: 9 and a reverse primer of SEQ ID NO: 10;
f) Lm0127, which can be detected by a forward primer of SEQ ID NO: 11 and a reverse primer of SEQ ID NO: 12;
g) Lm1650, which can be detected by a forward primer of SEQ ID NO: 13 and a reverse primer of SEQ ID NO: 14;
h) LE5100, which can be detected by a forward primer of SEQ ID NO: 15 and a reverse primer of SEQ ID NO: 16;
i) LE5200, which can be detected by a forward primer of SEQ ID NO: 17 and a reverse primer of SEQ ID NO:18;
j) HB2600, which can be detected by a forward primer of SEQ ID NO: 19 and a reverse primer of SEQ ID NO: 20; and
k) TG353, which can be detected by a forward primer of SEQ ID NO: 21 and a reverse primer of SEQ ID NO: 22.
US Pat. No. 10,363,253

COMBINATION PRODUCTS FOR THE TREATMENT OF RSV

Janssen Sciences Ireland ...

1. A combination comprising 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl-(methyl)-1-(2,2,2-trifluoroethyl)-1.3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, or a pharmaceutically acceptable salt thereof, as Compound A, and one or more Compound B selected from ribavirin, GS-5806, MDT-637, A-60444, AZ-27, CR9501, palivizumab, N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)-benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide, and 4-amino-8-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-6,6-dimethyl-2-(4-methyl-3-nitrophenyl)-3H-imidazo[4,5h]isoquinoline-7,9(6H, 8H)-dione.
US Pat. No. 10,364,277

DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASES

NEWSOUTH INNOVATIONS PTY ...

1. A method for detecting the presence or absence of an immune cell or antibody in a subject comprising:contacting a biological sample obtained from the subject with a polypeptide, wherein the polypeptide consists of
SEQ ID NO: 2 (KRFNALQYL) or SEQ ID NO: 3 (KRFNALQCL); and
detecting the presence or absence of a binding interaction between the polypeptide and an immune cell or antibody in said sample.
US Pat. No. 10,362,742

MELON PLANTS WITH WHITEFLY RESISTANCE

NUNHEMS B.V., Nunhem (NL...

1. A non-wild, cultivated Cucumis melo plant, or part thereof, comprising resistance against whitefly, wherein said resistance is conferred by an introgression fragment on chromosome 11 in homozygous or heterozygous form and wherein said introgression fragment is from a wild plant of the species Cucumis melo, a representative sample of seeds has been deposited under accession number NCIMB 41965 and NCIMB 41966, and wherein said introgression fragment comprises at least one of the following Single Nucleotide Polymorphism (SNP) markers:a) the CC genotype or CT genotype for the SNP marker mME20364 in SEQ ID NO: 1;
b) the AA genotype or AG genotype for the SNP marker mME17490 in SEQ ID NO: 2;
c) the CC genotype or CT genotype for the SNP marker mME15248 in SEQ ID NO: 3;
d) the CC genotype or CT genotype for SNP marker mME17306 in SEQ ID NO: 4;
e) the AA genotype or AT genotype for SNP marker mME26059 in SEQ ID NO: 5;
f) the GG genotype or GA genotype for SNP marker mME38084 in SEQ ID NO: 6;
g) the CC genotype or AC genotype for SNP marker mME21974 in SEQ ID NO: 7;
h) the CC genotype or CT genotype for SNP marker mME12777 in SEQ ID NO: 8;
i) the GG genotype or GA genotype for SNP marker mME15151 in SEQ ID NO: 9;
j) the CC genotype or CA genotype for SNP marker mME26139 in SEQ ID NO: 10;
k) the CC genotype or CA genotype for SNP marker mME48762 in SEQ ID NO: 11;
l) the CC genotype or CT genotype for SNP marker mME25039 in SEQ ID NO: 12; and/or
m) the TT genotype or TC genotype for SNP marker mME40109 in SEQ ID NO: 13.
US Pat. No. 10,364,278

CHIMERIC FIBROBLAST GROWTH FACTOR 23 PROTEINS AND METHODS OF USE

New York University, New...

1. A chimeric protein comprising:an N-terminus coupled to a C-terminus, wherein the N-terminus comprises an FGF1 portion beginning at any one of residues 1 to 25 and ending at any one of residues 150 to 155 of SEQ ID NO: 1,
wherein the FGF1 amino acid positions corresponding to those selected from the group consisting of N33, K127, K128, N129, K133, R134, R137, Q142, K143, and combinations thereof are substituted to decrease binding affinity for heparin and/or heparan sulfate compared to FGF1 without substitution, and
wherein the C-terminus comprises a C-terminal portion of an FGF23 comprising amino acid residues 161-251 of SEQ ID NO: 233.
US Pat. No. 10,364,279

PD-L1 AND PD-L2-BASED FUSION PROTEINS AND USES THEREOF

Thomas Jefferson Universi...

1. A fusion protein comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and the second domain comprises a polypeptide that binds to and triggers a TRAIL receptor, wherein the polypeptide that binds to and triggers PD-1 comprises amino acids 1-220 of SEQ ID NO: 5 and the polypeptide that binds to and triggers a TRAIL receptor comprises the amino acid sequence of SEQ ID NO: 15.
US Pat. No. 10,362,744

LETTUCE VARIETY 45-246 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A seed of lettuce variety 45-246 RZ, a sample of seed of said variety having been deposited under NCIMB Accession No. 42636.
US Pat. No. 10,366,841

ELECTROLYTIC CAPACITOR

Panasonic Corporation, O...

1. An electrolytic capacitor comprising:an anode body;
a dielectric layer formed on the anode body; and
a conductive polymer layer covering at least a part of the dielectric layer;
wherein:
the conductive polymer layer comprises a conductive polymer and a polymer dopant;
the polymer dopant comprises:
(A) a first unit originating from a first monomer having a polymerizable group and a sulfonate group; and
(B) a second unit originating from a second monomer having a polymerizable group and a phosphorus-containing group;
the phosphorus-containing group is represented by at least one of following general formulae:
—P(?O)(OR1)(OR2),  general formula (1):
—PH(?O)(OR3), and  general formula (2):
—PH2(?O),  general formula (3):in the general formulae (1) to (3), each of R1, R2 and R3 is independently a hydrogen atom, a hydrophilic group, a C1 to C3 alkyl group, or a cationic group, anda proportion of the second unit ranges from 5% by mole to 50% by mole both inclusive with respect to a total of the first unit and the second unit in the polymer dopant.
US Pat. No. 10,364,281

IMMUNOTHERAPY AGAINST MELANOMA AND OTHER CANCERS

IMMATICS BIOTECHNOLOGIES ...

1. A method for treating a patient who has cancer comprising administering to the patient a population of activated T cells that selectively recognize cancer cells that present a peptide consisting of the amino acid sequence of VLKADVVLL (SEQ ID NO: 42),wherein said cancer is selected from the group consisting of melanoma, acute myelogenous leukemia, breast cancer, bile duct cancer, brain cancer, chronic lymphocytic leukemia, colorectal carcinoma, esophageal cancer, gallbladder cancer, gastric cancer, hepatocellular cancer, non-Hodgkin lymphoma, non-small cell lung cancer, ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer, small cell lung cancer, urinary bladder cancer, and uterine cancer.
US Pat. No. 10,365,562

COATING COMPOSITIONS FOR USE WITH AN OVERCOATED PHOTORESIST

Rohm and Haas Electronic ...

1. A coated substrate comprising:(a) a layer of a coating composition on a substrate, the coating composition comprising a polyester resin that comprises one or more uracil moieties,
wherein the composition coating layer further comprises phenyl or anthacene groups, or where the uracil moieties are halogen-substituted; and
(b) a photoresist layer over the coating composition layer.
US Pat. No. 10,362,746

WHEAT CULTIVAR 01071514

Monsanto Technology LLC, ...

1. A plant of wheat cultivar 01071514, wherein a sample of seed of said cultivar has been deposited under ATCC Accession No. PTA-125548.
US Pat. No. 10,364,283

COLLAGEN HYDROLYSATE AND USE THEREOF

GELITA AG, Eberbach (DE)...

1. A collagen hydrolysate which is produced by enzymatic hydrolysis of type-B bone gelatin, wherein the collagen hydrolysate is formed from hydrolyzed collagen peptides of which at least 50% by weight have a molecular weight of 1,500 Da to 13,500 Da, and which have a weight average molecular weight in the range from 4,000 Da to 8,000 Da, wherein the bone gelatin is produced by alkaline breakdown of collagen from bones of vertebrates.
US Pat. No. 10,366,844

ELECTROCHEMICAL CELL

Seiko Instruments Inc., ...

1. An electrochemical cell comprising:an electrode body including a positive electrode body and a negative electrode body; and
an exterior body housing the electrode body, wherein
the exterior body includes:
a first container having a bottomed cylindrical shape and including a first circumferential wall section;
a second container having a bottomed cylindrical shape and including a second circumferential wall section surrounding the first circumferential wall section, the second container housing the electrode body between the second container and the first container; and
a fusing member interposed between the first circumferential wall section and the second circumferential wall section and fused to the first circumferential wall section and the second circumferential wall section, the fusing member comprising a thermally deformable layer of material different from that the first container.
US Pat. No. 10,362,750

WHEAT CULTIVAR 01071570

Monsanto Technology LLC, ...

1. A plant of wheat cultivar 01071570, wherein a sample of seed of said cultivar has been deposited under ATCC Accession No. PTA-125545.
US Pat. No. 10,364,286

MONOCLONAL ANTI-ALPHA-SYNUCLEIN ANTIBODIES FOR PREVENTING TAU AGGREGATION

1. A method for treating Alzheimer's disease without Lewy body pathology in a patient comprising:providing a monoclonal antibody, or an antigen-binding fragment thereof, that specifically binds alpha-synuclein to a patient having Alzheimer's disease without Lewy body pathology in an amount effective to inhibit aggregation of tau in the patient, wherein:
(i) the antibody, or antigen-binding fragment thereof, comprises:
a Heavy Chain CDR1 having the amino acid sequence of SEQ ID NO:1;
a Heavy Chain CDR2 having the amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:33, SEQ ID NO:34, or SEQ ID NO:35;
a Heavy Chain CDR3 having the amino acid sequence of SEQ ID NO:3;
a Light Chain CDR1 having the amino acid sequence of SEQ ID NO:4;
a Light Chain CDR2 having the amino acid sequence of SEQ ID NO:5; and
a Light Chain CDR3 having the amino acid sequence of SEQ ID NO:6; or
(ii) the antibody, or antigen-binding fragment thereof, comprises:
a Heavy Chain CDR1 having the amino acid sequence of SEQ ID NO:20;
a Heavy Chain CDR2 having the amino acid sequence of SEQ ID NO:21;
a Heavy Chain CDR3 having the amino acid sequence of SEQ ID NO:22;
a Light Chain CDR1 having the amino acid sequence of SEQ ID NO:23;
a Light Chain CDR2 having the amino acid sequence of SEQ ID NO:24; and
a Light Chain CDR3 having the amino acid sequence of SEQ ID NO:25.
US Pat. No. 10,364,288

ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF

Biogen MA Inc., Cambridg...

1. An antibody or antigen-binding fragment thereof that binds to glycoprotein IIb/IIIa (GPIIb/IIIa), wherein the antibody or the antigen-binding fragment thereof comprises a heavy chain variable region (VH) comprising VH complementarity determining region (CDR)1, VH CDR2, and VH CDR3, wherein:the VH CDR1 comprises the amino acid sequence AYAMS (SEQ ID NO:31);
the VH CDR2 comprises the amino acid sequence SISSGGTTYYPDSVKR (SEQ ID NO:32); and
the VH CDR3 comprises the amino acid sequence GGDYGYALDY (SEQ ID NO:33); and
wherein the antibody or the antigen-binding fragment thereof comprises a light chain variable region (VL) comprising VL CDR1, VL CDR2, and VL CDR3, wherein:
the VL CDR1 comprises the amino acid sequence RASSSVNYMY (SEQ ID NO:34);
the VL CDR2 comprises the amino acid sequence YTSNLAP (SEQ ID NO:35); and
the VL CDR3 comprises the amino acid sequence QQFSSSPWT (SEQ ID NO:36).
US Pat. No. 10,364,290

ANTI-HER3/HER4 ANTIBODIES BINDING TO THE BETA-HAIRPIN OF HER3 AND THE BETA-HAIRPIN OF HER4

Hoffmann-La Roche Inc., ...

1. An isolated nucleic acid encoding an antibody that binds to human HER3 and binds to human HER4, wherein the antibody comprises:(a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:25,
(b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:26,
(c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:27,
(d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:28,
(e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:29, and
(f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:30.
US Pat. No. 10,362,755

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH475588

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH475588, produced by crossing a first plant of variety CV181138 with a second plant of variety CV759867, wherein representative seeds of said varieties CV181138 and CV759867 are deposited under ATCC Accession Nos. PTA-123825 and PTA-124497, respectively.
US Pat. No. 10,363,267

DIARRHEA-PREVENTING NUTRITIONAL COMPOSITION

OTSUKA PHARMACEUTICAL FAC...

1. A nutritional composition for preventing diarrhea comprisinga pectin having a degree of esterification of 10 to 30%, a degree of amidation of 0 to 25%, and a degree of free acids of 64% or more and less than 85%,
lipid,
carbohydrate other than the pectin, and
protein,
wherein the pectin has a weight-average molecular weight of 350000 to 600000.
US Pat. No. 10,362,756

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH482861

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH482861, produced by crossing a first plant of variety CV181138 with a second plant of variety CV093813, wherein representative seeds of said varieties CV181138 and CV093813 are deposited under ATCC Accession Nos. PTA-123825 and PTA-123818, respectively.
US Pat. No. 10,362,757

SOYBEAN CULTIVAR S170156

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S170156, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125398.
US Pat. No. 10,364,293

POLYPEPTIDE BINDING TO EXTRACELLULAR DOMAIN OF EPIDERMAL GROWTH FACTOR RECEPTOR

KOREA ADVANCED INSTITUTE ...

1. A polypeptide which has the ability to bind specifically to epidermal growth factor receptor protein and comprises the amino acid sequence of any one of SEQ ID NOS: 6 to 8.
US Pat. No. 10,363,270

METHODS FOR ENGINEERING ALLOGENEIC AND IMMUNOSUPPRESSIVE RESISTANT T CELL IMMUNOTHERAPY

CELLECTIS, Paris (FR)

1. A method for treating a cancer patient using immunotherapy comprising:providing primary human T cells from a single donor;
co-electroporating into said primary human T-cells:
(a) RNAs encoding two half TALE-nucleases having Fok-I catalytic domains, wherein the two half TALE-nucleases dimerize and recognize two half-targets separated by a spacer of 11-15 bp and cleave the target sequence of SEQ ID NO:40 within a gene encoding CD52, and
(b) RNAs encoding two half TALE-nucleases having Fok-I catalytic domains,
wherein the two half TALE-nucleases dimerize and recognize two half-targets separated by a spacer of 11-15 bp and cleave the target sequence of SEQ ID NO:37 within a gene encoding TCR?,
to generate doubly-inactivated human T-cells having both the CD52 and the TCR? genes inactivated;
modifying the doubly inactivated human T-cells to express a chimeric antigen receptor; and
infusing at least 104 of the doubly inactivated human T-cells expressing a chimeric antigen receptor into said cancer patient for immunotherapy treatment.
US Pat. No. 10,365,070

BALLISTIC RESISTANT ARTICLE WITH NON-UNIFORMLY DISTRIBUTED MATRIX MATERIAL AND METHOD TO MANUFACTURE SAID ARTICLE

TEIJIN ARAMID B.V., Arnh...

1. A ballistic resistant article comprising at least one consolidated composite,wherein the at least one consolidated composite comprises a layer A and a layer B bonded to one another, each layer A and each layer B having
a first surface,
a second surface opposite to the first surface, and
a cross-section extending from the first surface to the second surface,
and each layer A and each layer B comprises a network of fibers having a strength of at least 800 mN/tex (1100 MPa) according to ASTM D 7269-07, and the fibers in each layer A and each layer B are impregnated with a matrix material,
wherein the matrix material is distributed along the cross-section of each layer in a concentration gradient in which the concentration starts with a maximum value on the first surface, so that the first surface is rich in matrix material, decreases along the cross-section and reaches a minimum value on the second surface, so that the second surface is poor in matrix material, and the matrix material comprises a mixture of 75 to 95 wt. % of a polychloroprene, and 5 to 25 wt. % of a random copolymer of vinyl chloride and an acrylic ester, based on a weight of the mixture.
US Pat. No. 10,362,770

TRANSGENIC ANIMAL FOR PRODUCTION OF ANTIBODIES HAVING MINIMAL CDRS

Crystal Bioscience Inc., ...

1. A transgenic chicken that comprises a genome comprising a recombinant immunoglobulin heavy chain (IgH) locus comprising:(a) a functional IgH gene comprising a nucleic acid encoding a heavy chain variable region comprising:
(i) heavy chain complementarity determining (CDR) regions; and
(ii) a heavy chain framework; and,
(b) a plurality of pseudogenes that encode heavy chain variable regions each comprising:
(i) heavy chain CDR regions; and
(ii) a heavy chain framework region that is identical in amino acid sequence to the heavy chain framework of a) (ii);
wherein said nucleic acid of (a) and pseudogene of (b), are exogenous to the genome of said transgenic chicken,
wherein said plurality of pseudogenes are operably linked to said functional IgH gene and donate nucleotide sequences to the nucleic acid of (a) by gene conversion in said transgenic chicken; and
wherein said transgenic chicken expresses a polyclonal antiserum comprising a diversified IgH variable region.
US Pat. No. 10,363,282

ANALOGS OF C5A AND METHODS OF USING SAME

Board of Regents of The U...

1. A method of activating an immune cell at a site of infection or disease comprising administering an effective amount of an oligopeptide C-terminal analog of C5a to a mammal, wherein said immune cell is an antigen presenting cell, said analog not attached to an antigen, and said analog having response-selective C5a receptor binding activity, wherein the analog is SEQ ID NO: 4.
US Pat. No. 10,362,771

METHOD FOR KNOCK-IN OF DNA INTO TARGET REGION OF MAMMALIAN GENOME, AND CELL

KYOTO UNIVERSITY, Kyoto ...

1. A method for knock-in of a donor DNA into the genome of a cell, comprising introducing at least one artificial nuclease system G capable of cleaving one or two target sequences G of the cell genome, the donor DNA, and two single-stranded oligonucleotides (ssODNs) into the cell,the artificial nuclease system G cleaving the one or two target sequences G on the cell genome to generate two DNA double-strand break (DSB) sites on the cell genome,
the two ssODNs being Up-ssODN complementary to DSB site g1, one of the DSB sites generated by the target sequence G cleavage of the cell genome, and to upstream introduction site D1 of the donor DNA, and Down-ssODN complementary to DSB site g2, the other DSB site of the cell genome, and to downstream introduction site D2 of the donor DNA, and
the donor DNA being knocked-in between the two DSB sites g1 and g2 in the one or two target sequences G of the cell genome using the two ssODNs (Up-ssODN and Down-ssODN),
wherein the donor DNA is a plasmid comprising one or two target sequences, the artificial nuclease system comprises artificial nuclease system G comprising Cas9 nuclease and one or two guide RNAs-G (gRNAs-G) corresponding to the one or two target sequences G of the cell genome, and artificial nuclease system D comprising Cas9 nuclease and one or two guide RNAs-D (gRNAs-D) corresponding to the one or two target sequences D of the donor DNA, the one or two target sequences G of the cell genome are cleaved by the artificial nuclease system G to generate DSB sites g1 and g2 on the cell genome, and the one or two target sequences D on the donor DNA plasmid are cleaved by the artificial nuclease system D to generate upstream introduction site D1 and downstream introduction site D2 of the plasmid-derived donor DNA to be knocked-in into the genome.
US Pat. No. 10,363,541

SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE

IMMUNOLIGHT, LLC., Detro...

1. A method for modifying a hydrophobic polymer surface, comprising:disposing in contact with the hydrophobic polymer surface a liquid composition comprising monomeric precursors to a hydrophilic polymer and one or more energy modulation agents, wherein the one or more energy modulation agents are resistant to chemical interaction with the liquid composition and hydrophobic polymer surface; and
applying energy from at least one of x-rays, gamma rays, or an electron beam into the liquid composition, wherein the applied energy interacts with the one or more energy modulation agents and internally generates light inside the liquid composition, thereby causing the monomeric precursors to polymerize and react with the hydrophobic polymer surface, thereby grafting the hydrophilic polymer onto the hydrophobic polymer surface.
US Pat. No. 10,363,290

BUTYRYLCHOLINESTERASE ZWITTERIONIC POLYMER CONJUGATES

KODIAK SCIENCES INC., Pa...

1. A fusion protein comprising: a butyrylcholinesterase enzyme or carboxy terminal truncation fragment thereof and an immunoglobulin (Ig) domain or fragment thereof, wherein a linker is positioned between and connecting the butyrylcholinesterase enzyme or fragment thereof and the Ig domain of fragment, wherein the Ig domain or fragment thereof comprises substitutions L234A, L235E, and G237A per EU numbering which corresponds to substitutions L14A, L15E, and G17A as numbered within SEQ ID NO: 8, wherein the linker is selected from the group consisting of at least one of Q, GOG, GGGGS (SEQ ID NO: 22), GGGS (SEQ ID NO: 23), GGGES (SEQ II) NO: 24), GGGSGGGSGGGS (SEQ ID NO: 21), and GGSGGGSGGGS (SEQ ID NO: 25).
US Pat. No. 10,363,547

METHODS FOR MAKING CATALYST SYSTEMS

Saudi Arabian Oil Company...

1. A method for making a catalyst system, the method comprising:introducing one or more alkali or alkaline earth metals to a zincosilicate support material; and
introducing one or more platinum group metals to the zincosilicate support material; and
wherein the zincosilicate support material comprises an MFI framework type structure incorporating at least silicon and zinc.
US Pat. No. 10,363,549

CHROMIUM OXYFLUORIDE CATALYSTS HAVING HIGH FLUORINATION ACTIVITY

Arkema Inc., King of Pru...

1. A chromium oxyfluoride catalyst active for fluorination of a chlorinated compound, wherein the chromium oxyfluoride catalyst is comprised of a first chromium species and a second chromium species, wherein the first chromium species exhibits a first X-ray photoelectron spectroscopy (XPS) chromium Cr 2p3/2 peak between 576.9 eV+/?0.2 eV and 578.0 eV+/?0.2 eV and the second chromium species exhibits a second X-ray photoelectron spectroscopy (XPS) chromium Cr 2p3/2 peak between 580.0 eV+/?0.2 eV and 581.4 eV+/?0.2 eV and wherein the intensity of the second XPS chromium peak is greater than the intensity of the first XPS chromium peak.