US Pat. No. 10,189,325

AMPHIBIOUS VEHICLE AND CONTROL METHOD FOR THE SAME

MITSUBISHI HEAVY INDUSTRI...

1. An amphibious vehicle, comprising:an engine;
at least one land traveling device;
at least one water propelling device;
a power distribution device configured to distribute power outputted from the engine between land travel power which is to be supplied to the at least one land traveling device and water propulsion power which is to be supplied to the at least one water propelling device;
a slippage-amount detection device configured to detect a slippage amount of the at least one land traveling device relative to ground; and
a controller configured to adjust at least the land travel power, of the land travel power and the water propulsion power, on the basis of the slippage amount detected by the slippage-amount detection device,
wherein the controller is configured to reduce the land travel power and increase or maintain unchanged the water propulsion power, if the slippage amount detected by the slippage-amount detection device is greater than a threshold while the land travel power and the water propulsion power are supplied respectively to the at least one land traveling device and the at least one water propelling device for landing from water to land.

US Pat. No. 10,189,317

PNEUMATIC TIRE HAVING TWISTED BEAD CORDS

SUMITOMO RUBBER INDUSTRIE...

1. A pneumatic tire having twisted bead cords comprising a carcass comprising a carcass ply extending from a tread portion through a sidewall portion to a bead core of a bead portion; whereinthe bead core is made of axially inner and outer core pieces, and a radially inner end portion of the carcass ply is held between the inner and outer core pieces without turning-up around the bead core;
the inner and outer core pieces are each formed of a helical body by each helically winding a bead cord made of a plurality of twisted steel wires around a tire axis from radially inward to outward; and
in the inner core piece, a twisting direction of the bead cord around the cord axis is in a direction that is the same as a winding direction of the bead cord around the tire axis in a side view from an axial outward of the tire, and
in the outer core piece, a twisting direction of the bead cord around the cord axis is in a direction that is opposite of a winding direction of the bead cord around the tire axis in a side view from an axial outward of the tire;
wherein a twisting direction of a sheath in the inner core piece around the cord axis and a twisting direction of a sheath in the outer core piece around the cord axis are the same direction.

US Pat. No. 10,189,312

TIRE

BRIDGESTONE CORPORATION, ...

1. A pneumatic tire comprising:a carcass toroidally extending between a pair of bead portions;
an inclined belt formed by two inclined belt layers including cords that extend at an inclination angle of equal to or greater than 35° and equal to or smaller than 90° relative to a tire circumferential direction and a circumferential belt formed by one or more circumferential belt layers including cords that extend at an inclination angle of 5° or less relative to the tire circumferential direction, the inclined belt and the circumferential belt being provided at an outer side of a crown portion of the carcass in a tire radial direction; and
a tread disposed at an outer side of the circumferential belt in the tire radial direction;
wherein the circumferential belt has a higher tire circumferential direction rigidity per unit width in a central region including a tire equator than in other regions;
in a region of a surface of the tread including at least the tire equator, the tread includes a land portion continuous in the tire circumferential direction;
when an internal pressure of the pneumatic tire is set to 250 kPa or higher, a sectional width SW and an outer diameter OD of the pneumatic tire satisfy either one of the following relational expressions:
SW/OD?0.26 and SW<165 mm, or
OD?2.135×SW+282.3 mm and SW?165 mm; and
a width of the central region in a tire width direction, centered on a tire equator, is between 0.2 and 0.6 times a width of the circumferential belt in the tire width direction.

US Pat. No. 10,189,306

REAR HUB AND BICYCLIC AXLE

Canyon Bicycles GmbH, Ko...

1. A rear hub comprising:a hub body rotatably supported on a hub axle,
a sprocket carrier rotatably supported on the hub axle, and
a freewheel mechanism for axially coupling the hub body and the sprocket carrier,
further comprising a decoupling element for decoupling the hub body and the sprocket carrier,
wherein the decoupling element is actuated by a manual actuating element which is connected with an actuating mechanism on a bicycle handlebar.

US Pat. No. 10,189,303

BICYCLE RIM FOR TUBELESS TIRE

HED CYCLING PRODUCTS, INC...

1. A bicycle rim assembly comprising:a bicycle rim comprising:
a center channel that is continuous from a channel first outer sidewall to a channel second outer sidewall, the channel first outer sidewall disposed to a first side of a centerline of the rim and the channel second outer sidewall disposed to a second side of the centerline of the rim, the channel having a channel diameter;
a pair of rim sidewalls disposed at the lateral peripheries of the bicycle rim;
a pair of bead seats disposed proximate to the rim sidewalls and having a bead seat diameter;
an attachable annular strip formed separately from the bicycle rim and attached to the bicycle rim along a center line of the center channel, the attachable annular strip comprising:
a set of strip sidewalls;
a center section extending between the strip sidewalls, wherein the strip sidewalls are spaced at less than a center channel width such that the strip forms a pair of bead channels in cooperation with the channel first outer sidewall and channel second outer sidewall, the bead channels positioned laterally inward of the bead seats, the pair of bead channels having a bead channel diameter that is less than the bead seat diameter, and the center section having a radially outer surface with a diameter that is greater than the bead seat diameter.

US Pat. No. 10,189,297

WALL APPLIQUé

18. A wall appliqué comprising:a body portion consisting of a single layer having a front side and a back side wherein the body portion is a polyurethane material that is not a cross-linked polyethylene foam and sized and shaped to be used as architectural embellishment for a wall wherein the body portion has a thickness that is greater than .033 inches and less than ?? and has a Shore hardness of 10-60 and wherein the body portion is configured to be cut with handheld scissors; and
an adhesive portion comprising an adhesive layer wherein the adhesive portion is directly on the back side of the single-layer body portion wherein the adhesive layer is configured to bond the body portion to a wall by applying pressure to the body portion when the body portion is positioned on a wall wherein the adhesive portion is co-extensive with the back side of the body portion.

US Pat. No. 10,189,279

LIQUID DISCHARGE APPARATUS AND MEDIUM FLATTENING METHOD

Seiko Epson Corporation, ...

1. A medium flattening method when a medium is transported by being adhered to an adhesive layer which is on a surface of a transport belt, the method comprising:detecting a presence or absence of floating being generated in the medium on the transport belt using a first sensor;
executing a process for flattening to flatten the floating in the medium in the case where the floating exists;
confirming whether or not the floating in the medium is eliminated by executing the process for the flattening using a second sensor; and
transporting the medium, where the floating is eliminated using the process for the flattening, to a liquid discharge region of a liquid discharge section,
the executing of the process for the flattening including executing the process for the flattening with regard to the medium and liquid discharge with regard to the medium in parallel,
the process for the flattening being executed by moving a pressure roller that adheres the medium to the adhesive layer along a transport direction of the medium in an area between the first sensor and the second sensor in the transport direction.

US Pat. No. 10,189,265

PRINTING FLUID CARTRIDGE

HEWLETT-PACKARD DEVELOPME...

1. A printing fluid cartridge comprising:a housing; and
an assembly supported by the housing and comprising:
a molding; and
a non-fluid dispensing die electronic device embedded in the molding, wherein:
a thickness of the molding varies at different locations of the molding, and
the non-fluid dispensing die electronic device is buried in a thicker part of the molding.

US Pat. No. 10,189,263

REPLENISHMENT CONTAINER AND INKJET RECORDING DEVICE COMPRISING SAME

Hitachi Industrial Equipm...

1. A replenishment container comprising:a storage member comprising a storage chamber that stores ink or a solvent and comprising an opening formed therein;
a stopper member configured to seal the opening of the storage member; and
a lid member configured to cover the stopper member,
wherein the replenishment container comprises a seal member that has a through hole between the stopper member and the lid member,
the lid member comprises a through hole formed concentrically with the through hole of the seal member and an inner diameter of part or a whole of the through hole of the seal member is smaller than an inner diameter of the through hole of the lid member, and
further comprising an absorbing member between the seal member and the lid member, the absorbing member having a through hole formed concentrically with a through hole provided in the seal member and the lid member, and
wherein a thin wall portion, which has a smaller thickness than a surrounding area, is formed annularly in the stopper member.

US Pat. No. 10,189,250

PRINTHEAD, ELEMENT SUBSTRATE, AND PRINTING APPARATUS

CANON KABUSHIKI KAISHA, ...

1. A printhead comprising:a plurality of element substrates that each include a first element substrate adjacent to a second element substrate in a first direction,
wherein a planar shape of each of the first element substrate and the second element substrate is quadrilateral that has a first side and a second side along the first direction,
wherein the quadrilateral of the first element substrate has a first element substrate oblique side close to the second element substrate, the first element substrate oblique side obliquely intersecting with both of the first side and the second side of the first element substrate,
wherein the quadrilateral of the second element substrate has a second element substrate oblique side close to the first element substrate side, the second element substrate oblique side obliquely intersecting with both of the first side and the second side of the second element,
wherein the first element substrate and the second element substrate each have a print element array in which a plurality of print elements are arrayed in the first direction, and each have a plurality of driving circuits that respectively correspond to the plurality of print elements, each corresponding print element and driving circuit being arranged in a second direction that intersects with both of the first direction and a third direction along the first element substrate oblique side and along the second element substrate oblique side, and each of the plurality of driving circuits being arranged on either a side of the first side or a side of the second side with respect to a print element corresponding to a driving circuit,
wherein a first print element array arranged in the first element substrate includes a first print element that is closest to the second element substrate in the first direction, and a second print element array arranged in the second element substrate includes a second print element that is closest to the first element substrate in the first direction, and
wherein an order of arrangement in the second direction of at least the first print element and a first driving circuit corresponding to the first print element is opposite to an order of arrangement in the second direction of the second print element and a second driving circuit corresponding to the second print element.

US Pat. No. 10,189,249

RECORDING ELEMENT SUBSTRATE, LIQUID DISCHARGE HEAD, AND RECORDING APPARATUS

Canon Kabushiki Kaisha, ...

1. A recording element substrate comprising:a recording module including a plurality of recording elements and first logic circuits corresponding to the plurality of recording elements;
a memory module including a plurality of memory elements and second logic circuits corresponding to the plurality of memory elements;
a signal supply circuit configured to supply a signal for controlling the recording elements and a signal for controlling the memory elements; and
a common line configured to connect the signal supply circuit to the plurality of first logic circuits and the plurality of second logic circuits in common,
wherein the recording elements are arranged along an extending direction in which the common line extends, and the memory modules are disposed between the common line and the recording elements.

US Pat. No. 10,189,239

ABILITY TO THREE-DIMENSIONALLY PRINT AN APERTURE MASK ON A MULTI SPECTRAL FILTER ARRAY

MATERION CORPORATION, Ma...

7. A three-dimensional inkjet printer, comprising:a tray comprising a vacuum chuck configured to support an associated prefabricated multi-spectral optical filter array; and
a print block, comprising:
at least one inkjet head in fluid communication with a reservoir for storing associated photopolymer resin, the at least one inkjet head configured to deposit the associated photopolymer resin onto a surface of the prefabricated multi-spectral optical filter array forming an aperture mask thereon, and
at least one ultraviolet lamp for illuminating deposited photopolymer resin on the surface of the prefabricated multi-spectral optical filter array, wherein the vacuum chuck is further configured to locate a start position of the at least one inkjet head relative to the prefabricated multi-spectral optical filter array,
wherein the prefabricated multi-spectral optical filter array comprises a plurality of optical filter elements of different optical filter types, the optical filter elements having slanted sidewalls, the optical filter elements bonded together at the slanted sidewalls to form an optical filter array.

US Pat. No. 10,189,223

BEAD FORMING APPARATUS AND FORMING METHOD

FUJI SEIKO CO., LTD., Ha...

1. A bead forming apparatus comprising:a rotatable drum having a plurality of divided bodies dividedly arranged along a circumference of the rotatable drum and being adapted to be wrapped with a belt-shaped bead filler having a short base and two other long sides, around the rotatable drum in an annular shape;
a plurality of erection arms provided along the circumference and respectively swingably supported around respective pivots by the divided bodies of the rotatable drum so as to erect the bead filler by swinging the erection arms;
a swing device for swinging the erection arms, the swing device including a plurality of link mechanisms connected to the plurality of erection arms, respectively, and an actuating device comprising a plurality of cylinder devices, each having a respective piston rod, and an actuating member in the form of a ring placed at an end of the piston rods; and
a plurality of slide members provided as contact portions of the erection arms that come into contact with the bead filler so that the bead filler can be radially slidable relative to the erection arms,
wherein the plurality of slide members is formed by a plurality of rotatable rollers rotatably provided in a longitudinal direction of the plurality of erection arms so as to be rotatable about axes that are parallel to the respective pivots of the respective erection arm,
wherein each of the link mechanisms includes
a push bar that is slidable horizontally inside a guide member that is provided inside a respective divided body of the plurality of divided bodies,
a protrusion protruding from a respective erection arm of the plurality of erection arms, and
a link pivotally connected to the push bar at a first end of the link and pivotally connected to the protrusion at a second end of the link,
wherein the actuating device can achieve a first retracted position at which the actuating member is not in contact with the push bars while the plurality of erection arms are in a horizontal state, and
wherein the actuating device can move from the first position to a second, extended position at which the actuating member is in contact with a free end of each of the push bars so as to cause the erection arms to become erected by moving the second end of the links to be radially further from an axis of rotation of the rotatable drum in the second position of the actuating device than in the first position of the actuating device; the bead forming apparatus further comprising a diameter changing mechanism for changing a diameter of the rotatable drum as well as changing a radial distance of the push bars from the axis of rotation.

US Pat. No. 10,189,218

THERMAL COMPOSITE MATERIAL REPAIR UTILIZING VACUUM COMPRESSION

The Boeing Company, Chic...

1. An apparatus comprising:a flexible vacuum compression device for thermally curing a potting material within a hole in a surface of a composite material, the flexible vacuum compression device including:
a first end that is closed;
a second end opposite the first end that is open to form a cavity between the first end and the second end, wherein the second end includes an interface that is configured to generate an air tight seal when applied to the surface;
a partition, which extends from and is connected to a side wall of the flexible vacuum compression device, that traverses at least partially across the cavity to form a compartment within the cavity; and
a vacuum port having a passage through the first end and into the cavity;
a breathable insulator disposed within the compartment; and
a chemical-based heating pack disposed between the breathable insulator and the partition;
wherein a bottom surface of the partition includes a breathable pattern that, upon application of a vacuum source to the vacuum port, draws a vacuum within the cavity to cause the cavity to collapse and press the chemical-based heating pack and the partition proximate to the surface to thermally cure the potting material.

US Pat. No. 10,189,210

METHOD FOR PRINTING THREE-DIMENSIONAL PARTS WITH CRYSTALLIZATION KINETICS CONTROL

Stratasys, Inc., Eden Pr...

1. A method for printing a three-dimensional part with an additive manufacturing system, the method comprising:providing a part material compositionally including one or more semi-crystalline polymers and one or more secondary materials that are configured to retard crystallization of the one or more semi-crystalline polymers, wherein the one or more secondary materials are substantially miscible with the one or more semi-crystalline polymers;
melting the part material in the additive manufacturing system; and
forming at least a portion of a layer of the three-dimensional part from the melted part material in a build environment.

US Pat. No. 10,189,201

METHOD FOR MANUFACTURING A HOLLOW BODY, IN PARTICULAR A FUEL TANK

Plastic Omnium Advanced I...

1. A method for manufacturing a hollow body from a plastic material, said method comprising:molding a preform into shells in a molding tool;
joining an insert to an inner surface of a shell of said shells, said insert defining a sub volume within the hollow body to be made; and
joining together the shells to form the hollow body by closing the molding tool and applying a main pressure to a main volume enclosed by the shells,
wherein a sub pressure is applied to the sub volume while the main pressure is applied to the main volume, such that a pressure difference between the main volume and the sub volume is bigger than 0.20 bar and smaller than 3.00 bar, and
wherein a contour of the insert is defined by a wall and the insert is selected from a line, a valve, a liquid pump, a nipple, a baffle, a ventilation device and a liquid trap.

US Pat. No. 10,189,198

MULTI-LAYER HOSE AND HOSE FORMULATION

Swan Products, LLC, Sand...

1. A garden hose comprising:an extruded composite tube including a core layer and a jacket layer of a polyvinyl chloride (PVC) compound;
an intermediate reinforcement layer disposed between the core layer and the jacket layer, the intermediate reinforcement layer comprising one or more spiraled, braided or fabric filaments wound around the core layer to thereby define a plurality of diamond-shaped interstices; and
a tie layer disposed between the core layer and the jacket layer, such that the tie layer flows through the plurality of diamond-shaped interstices to fuse the core layer to the jacket layer;
wherein:
the PVC compound comprises:
100 PPH (parts in weight per hundred parts of resin) of PVC resin; and
45-75 PPH of plasticizer;
the PVC compound has a K value in a range of 79-85 measured according to standard ISO1628-2 and a specific gravity in a range of 1.17-1.23 measured according to standard ASTM D792;
the composite tube has a circular cylindrical cross-section and a wall thickness in a range of 115 to 145 mils (thousandths of an inch); and
a 12 inch length of the composite tube at zero fluid pressure maintains its circular cylindrical cross-section without kinking at a bend radius of less than 3 inches and the composite tube has a minimum burst pressure of 500 psi measured according to standard ISO 1402:2009.

US Pat. No. 10,189,197

SOFT AND VELVET TOUCH BARRIER LAMINATE

ESSEL PROPACK LIMITED, M...

1. A soft and velvet touch barrier laminate comprising:(a) a printable layer comprising a polypropylene elastomer;
(b) a core layer adjacent to the printable layer;
(c) a laminating layer adjacent to the core layer;
(d) a barrier layer between first and second bond layers, wherein the first bond layer is between the laminating layer and the barrier layer; and
(e) an inner polyethylene (PE) layer adjacent to the second bond layer which is in contact with the barrier layer;
wherein said polypropylene elastomer has Vicat softening temperature in the range of 60° C. to 90° C., wherein the printable layer further comprises high density polyethylene (HDPE); an anti-block additive; and a colorant.

US Pat. No. 10,189,193

METHOD FOR THE PRODUCTION OF A FLUID CONTAINER FOR A MOTOR VEHICLE, AND CORRESPONDING FLUID CONTAINER

AUDI AG, Ingolstadt (DE)...

12. A fluid container for a motor vehicle, said fluid container comprising:at least two shaped shells connected to one another and each formed as a unitary, single-layer component, each of the shells forming both an interior surface and an exterior surface of the fluid container, each of the shells having a single planar bottom and sidewalls extending from the bottom at an angle in relation to the bottom away from the bottom and a plurality of projections in spaced-apart relation to one another and to the sidewalls, with the plurality of projections being injection-molded off-tool.

US Pat. No. 10,189,192

DECORATIVE FOAM AND METHOD

NIKE, INC., Beaverton, O...

1. A foam midsole made by a method comprising:infusing a plurality of articles comprising a thermoplastic elastomer with a supercritical fluid, wherein the articles are pellets, beads, or particles;
removing the plurality of articles from the supercritical fluid, and either
(i) immersing the plurality of articles in a heated fluid to foam the plurality of articles, making a plurality of dyed foamed articles or
(ii) irradiating the plurality of articles with infrared or microwave radiation to foam the plurality of articles, making the plurality of dyed foamed articles;
wherein each of the plurality of dyed foamed articles include a first skin having a first skin thickness;
arranging the plurality of dyed foamed articles in a midsole mold; and
molding the plurality of dyed foamed articles together to form the foam midsole, the foam midsole including regions formed of the first skin of the each of the plurality of dyed foamed articles within the foam midsole and, on a molded outer surface of the foam midsole, a second skin having a second skin thickness;
wherein the plurality of dyed foamed articles are dyed during at least one of the infusing step and the immersing step, wherein dyeing the plurality of articles during the infusing step comprises infusing the plurality of articles with a supercritical fluid that has a dye dispersed or dissolved in the supercritical fluid such that the plurality of dyed foamed articles are made, and wherein dyeing the plurality of articles during the immersing step comprises immersing the plurality of articles in a heated fluid wherein the heated fluid is a heated fluid that contains a dye solution, such that the plurality of dyed foamed articles are made.

US Pat. No. 10,189,189

MOLDING METHOD AND MOLD THEREFOR

KAGA SANGYO CO., LTD., N...

1. A method of molding a product by rotating a mold, comprising:(i) filling a liquid synthetic resin material into the mold;
(ii) disposing the mold, which has been filled with the liquid synthetic resin material in step (i), in a vacuum interior of a housing of a mixer; and
(iii) driving the mixer to subject the mold in the vacuum interior to a planetary motion, thereby agitating the synthetic resin material while degassing it and generating an agitated/degassed synthetic resin material in the mold and thereby molding the product by rotational molding,
wherein the planetary motion is generated by driving the mixer to cause the mold to orbit about an orbital axis and simultaneously rotate about a rotational axis, wherein the rotation axis is eccentric from the orbital axis and is tilted relative to the orbital axis.

US Pat. No. 10,189,186

METHOD FOR FINISHING MATCHING SURFACES IN FORMING TOOL COMPONENTS

Ford Global Technologies,...

1. A tool-forming method comprising steps of:providing a core and a cavity that include respective core and cavity shutoff bands, the core and cavity being made entirely of steel with mating core and cavity parting planes that extend respectively therethrough;
removing portions of the core and cavity shutoff bands that are distal from the core and cavity parting planes;
stress relieving the core and cavity through tempering, wherein the core and cavity are heated to a temperature of from 550 degrees Celsius to 660 degrees Celsius, and wherein the core and cavity are then cooled at a slow rate to achieve a consistent hardness through the steel of the core and the cavity; and
refining exposed steel surfaces of the respective core and cavity shutoff bands, wherein the steel of the core and the steel of the cavity are removed to expose the core and cavity parting planes.

US Pat. No. 10,189,185

DEVICE FOR DISPLAYING IMAGE ON APPAREL

Nike, Inc., Beaverton, O...

1. A method for manufacturing a customizable image displaying device for incorporation in an article of footwear, the method comprising:receiving, by a mold making device, an electronic copy of an image, the electronic copy comprising an electronic mapping of a plurality of pixels of the image;
creating, by the mold making device, a mold having a cavity corresponding to the electronic copy of the image; and
pressing a footwear blank and a background layer against the mold, the footwear blank having a coloring agent, wherein the mold deforms the footwear blank and causes the footwear blank to fill the cavity, the deformed footwear blank comprising one or more raised areas and one or more recessed areas corresponding to the image, wherein the background layer comprises at least a portion of the article of footwear.

US Pat. No. 10,189,184

METHODS FOR MANUFACTURING THREE-DIMENSIONAL DEVICES AND DEVICES CREATED THEREBY

UNITED TECHNOLOGIES CORPO...

37. An assembly comprising:a metallic foil stack lamination mold; and
a cast component that fills a cavity of said metallic foil stack lamination mold, said cast component comprising a plurality of component surfaces, a predetermined component surface from said plurality of component surfaces having a predetermined surface condition;
wherein:
said cavity defines a single demolding opening for said mold;
said demolding opening defines a demolding direction in which said cast component is removable via said demolding opening from said cavity of said mold with damage to neither said cast component nor said mold;
said cavity defines a first cavity cross-sectional area that extends solely within a first cavity plane that is oriented perpendicularly to said demolding direction;
said cavity defines a second cavity cross-sectional area that extends solely within a second cavity plane that is oriented perpendicularly to said demolding direction;
said first cavity cross-sectional area is smaller than said second cavity cross-sectional area; and
said first cavity plane is closer to said demolding opening than said second cavity plane.

US Pat. No. 10,189,181

METHOD FOR SLICING WORKPIECE AND PROCESSING LIQUID

SHIN-ETSU HANDOTAI CO., L...

1. A method for slicing workpieces, comprising:forming a wire row by a wire spirally wound between a plurality of wire guides and traveling in an axial direction,
pressing a workpiece against the wire row while supplying a processing liquid comprising abrasive grains to a contact portion between the workpiece and the wire to slice the workpiece and thereby producing a waste slurry comprising at least a portion of the abrasive grains,
recovering at least a portion of the abrasive grains from the waste slurry,
subjecting the recovered abrasive grains to a treatment with a mixed liquid of sulfuric acid and hydrogen peroxide,
dispersing the treated abrasive grains into coolant to make a reused processing liquid, and
reusing the treated abrasive grains in the reused processing liquid for slicing of another workpiece.

US Pat. No. 10,189,177

ENGINEERED TIMBER PRODUCTS, COMPONENTS AND METHODOLOGIES

Wood Engineering Technolo...

1. A method of drying a plurality of sticks of square or rectangular cross-section, said method comprising or including the steps ofadvancing the sticks laterally onto an underlying frame of a plurality of frames comprising at least one adjacent pair of frames, each adjacent pair of frames receiving said plurality of sticks, which will allow drying of the underlying surface of the sticks,
squeezing the sticks when laterally received on the underlying frame to said underlying frame using an overlying frame carrying spaced penetrative members, said overlying frame with spaced penetrative members penetrating the upper surfaces of the sticks allowing drying of the upper most surface of the sticks, and
allowing and/or causing drying to occur whilst the sticks are so constrained by such squeezing;
wherein each adjacent pair of frames is actuatable to constrain said sticks;
wherein each underlying frame is skeletal; and
wherein a spacing of rails or bars of each frame are closer together near ends of said sticks than centrally of said sticks.

US Pat. No. 10,189,164

ROBOT, CONTROL DEVICE, AND ROBOT SYSTEM

Seiko Epson Corporation, ...

1. A robot comprising:a plurality of arms including first, second, and third arms, a total number of the plurality of arms being n, the first, second, and third arms being rotatable around first, second, and third axes, respectively;
a plurality of motors that respectively drive the plurality of arms, a total number of the plurality of motors being n, each motor being respectively provided in a corresponding one of the plurality of arms, the plurality of motors including first, second, and third motors, the first, second, and third motors driving the first, second, and third arms, respectively;
a plurality of encoders that respectively detect positions of the plurality of arms so as to provide detection signals, a total number of the plurality of encoders being n, each encoder being respectively provided in a corresponding one of the plurality of arms, the plurality of encoders including first, second, and third encoders, the detection signals including first, second, and third position detection signals, the first, second, and third encoders detecting the positions of the first, second, and third arms so as to provide the first, second, and third position detection signals, respectively;
a plurality of signal lines through which the detection signals detected by the plurality of encoders flow, a total number of the plurality of signal lines being L, the plurality of signal lines including first and second signal lines; and
a plurality of controllers that are configured to receive the position detection signals via the plurality of signal lines so as to control driving of the plurality of motors, a total number of the plurality of controllers being m, the plurality of controllers including first and second controllers,
wherein 2?L wherein the first and second position detection signals flow only through the first signal line, and the third position detection signal flows only through the second signal line, and
the first and third position detection signals are received only by the first controller so that the first controller is configured to control the driving of the first and third motors, and the second position detection signal is received only by the second controller so that the second controller is configured to control the driving of the second motor.

US Pat. No. 10,189,159

METHODS AND SYSTEMS FOR DETECTING STATES OF OPERATION OF A ROBOTIC DEVICE

X Development LLC, Mount...

1. A method comprising:controlling, by one or more computing devices, a robotic device to perform a predetermined motion to accomplish a task within an environment of the robotic device, wherein the robotic device includes (i) a motor configured to receive electrical power for causing movement of the motor, (ii) a transmission coupled to the motor, (iii) a torque sensor coupled to the transmission and configured to determine a torque of the transmission and a direction of rotation of the transmission, (iv) a link coupled to the transmission, and (v) an encoder configured to measure a velocity of the link, and wherein the predetermined motion involves the motor moving the link;
determining, by the one or more computing devices, an expected state of operation of the link of the robotic device, the expected state of operation being associated with performance of the predetermined motion;
while the robotic device is performing the predetermined motion:
determining, by the one or more computing devices, a first measurement of the electrical power received by the motor, wherein the firt measurement has a respective sign;
based on the velocity of the link measured by the encoder, the torque of the transmission determined by the torque sensor, and the direction of rotation of the transmission determined by the torque sensor, determining, by the one or more computing devices, a second measurement of mechanical power associated with the link, wherein the second measurement has a respective sign;
determining, by the one or more computing devices, a current state of operation of the link of the robotic device based on a comparison of the signs of the first and second measurements to predetermined reference data, wherein the predetermined reference data includes multiple distinct pairs of an electrical power measurement sign and a mechanical power measurement sign and correlates each pair with a state of operation of the link of the robotic device; and
making, by the one or more computing devices, a determination that the current state of operation differs from the expected state of operation; and
based on the determination that the current state of operation differs from the expected state of operation, controlling, by the one or more computing devices, the link of the robotic device to perform a physical action different from the predetermined motion.

US Pat. No. 10,189,158

ROBOT MANIPULATOR WITH MODULAR TORQUE CONTROLLED LINK

X DEVELOPMENT LLC, Mount...

1. An actuator system comprising:multiple torque controlled actuators arranged side-by-side, wherein a given torque controlled actuator of the multiple torque controlled actuators comprises one or more timing belt stages coupled in serial including an input stage for coupling to a motor and an output stage for coupling to a load, wherein the one or more timing belt stages couple rotation of the motor to rotation of an output of the output stage;
a common frame to couple the multiple torque controlled actuators in the side-by-side arrangement; and
a differential coupled to outputs of the multiple torque controlled actuators to create a multiple degree of freedom (DOF) actuated joint.

US Pat. No. 10,189,133

MEASUREMENT, CALIBRATION AND COMPENSATION SYSTEM AND METHOD FOR MACHINE TOOL

NATIONAL CHUNG SHAN INSTI...

1. A measurement, calibration and compensation system for a machine tool, comprising:a first positioning base having a first XY plane and a first XZ plane, wherein the first positioning base is for mounting on a machine bed of the machine tool and located at a lateral side of an x-axis linear translation stage of the machine tool, the x-axis linear translation stage is mounted on the machine bed, and the first positioning base is made of a material selected from a group consisting of a zero-expansion glass material, an Invar material, and a granite material;
two first speckle image sensors for mounting on an object holding unit of the machine tool, wherein the object holding unit is translatable on the x-axis linear translation stage along the x-axis, the first speckle image sensors separately sense along the x-axis a speckle position of the object holding unit at the first XY plane and a speckle position of the object holding unit at the first XZ plane before and after the machine tool is started, and a difference between the speckle positions of the object holding unit at the first XY plane before and after the machine tool is started and a difference between the speckle positions of the object holding unit at the first XZ plane before and after the machine tool is started are used for calibrating and compensating a position of the object holding unit by an axis control system when the machine tool is machining;
a second positioning base having a second XY plane and a second YZ plane, wherein the second positioning base is provided for mounting on the machine bed of the machine tool and located at a lateral side of a y-axis linear translation stage and a z-axis linear translation stage of the machine tool, the y-axis linear translation stage is mounted on the machine bed, and the z-axis linear translation stage is translatable on the y-axis linear translation stage along the y-axis and the second positioning base is made of a material selected from the group consisting of a zero-expansion glass material, an Invar material, and a granite material; and
two second speckle image sensors, separately mounting on a cutter holding unit and the z-axis linear translation stage of the machine tool, wherein the cutter holding unit is translatable on the z-axis linear translation stage along the z-axis, one of the two second speckle image sensors senses a speckle position of the cutter holding unit along the y-axis at the second XY plane before and after the machine tool is started for machining, the other second speckle image sensor senses a speckle position of the cutter holding unit along the Z axis at the second YZ plane before and after the machine tool is started, and a difference between the speckle positions of the cutter holding unit at the second XY plane before and after the machine tool is started and a difference between the speckle positions of the cutter holding unit at the second YZ plane before and after the machine tool is started are used calibrating and compensating a position of the cutter holding unit by the axis control system when the machine tool is machining.

US Pat. No. 10,189,132

CORE GRASPING APPARATUS

TOYOTA JIDOSHA KABUSHIKI ...

12. A core grasping apparatus that grasps a core including a core main body and a core print provided at one end of the core main body, the core grasping apparatus comprising:a first holding device including an inflatable and deflatable first holding part, the first holding device being configured to hold the core print by inflating the first holding part so as to bring the first holding part into contact with the core print;
a second holding device including an inflatable and deflatable second holding part, the second holding device being configured to hold the core print by inflating the second holding part so as to bring the second holding part into contact with the core print; and
a turning suppression part configured to suppress the core from turning upon the core print being held by the first holding device and the second holding device, the turning suppression part applying, to the core print, a force that suppresses a turning moment acting on the core around a straight line connecting portions of the core print at which the first holding part and the second holding part respectively come in contact with the core print, wherein
a third holding device including an inflatable and deflatable third holding part is used as the turning suppression part, and
the third holding part applies the force that suppresses the turning moment acting on the core to the core print by coming in contact with the core print at a position separated from the straight line connecting portions of the core print at which the first holding part and the second holding part respectively come in contact with the core print.

US Pat. No. 10,189,121

ORGANIC ACID-OR LATENT ORGANIC ACID-FUNCTIONALIZED POLYMER-COATED METAL POWDERS FOR SOLDER PASTES

1. Solder particles having a polyalkylene polymer with latent organic acid functional groups coated on at least a portion of the surface thereof, wherein the solder particles are made from an alloy selected from the group consisting of tin/silver/copper, tin/zinc, tin/bismuth, tin/lead, and tin/indium/bismuth and wherein the solder particles have a varied size distribution of diameters of about 0.5 to about 100 um, wherein the polyalkylene is selected from the group consisting of polyethylene, polypropylene, polybutylene and mixtures thereof and wherein the latent organic acid functional group is an anhydride.

US Pat. No. 10,189,110

PLASMA CUTTING METHOD AND PLASMA CUTTING DEVICE

KOMATSU INDUSTRIES CORPOR...

6. A plasma cutting device configured to cut out a plurality of cutout members from a plate blank, comprising:a mount table onto which the plate blank to be cut is mounted;
a plasma torch configured to generate a plasma arc and movable relative t the F fount table in, a horizontal direction and in an up-and-down direction; and
a controller programmed to control movement of the plasma torch relative to the mount table and generation of the plasma arc from the plasma torch, wherein
the controller is programmed to
receive a set data regarding a processing line;
form an aperture on an outer peripheral side of a given one of the cutout members by maintaining the plasma torch at a first height from the plate blank on the outer peripheral side or the given cutout member while the plasma arc is, being generated from the plasma torch and by moving the plasma torch relative to the plate blank by a predetermined distance in the horizontal direction; and
form a continuous cutting groove along an outer contour of the given cutout member by setting the plasma torch at a second height lower than the first height and by moving the plasma torch in the horizontal direction along an incision part and the processing line continuing to the incision part,
the controller being further programmed to set the plasma torch at a position lower than the first height when the plasma arc begins to be generated, and to then move the plasma torch in the horizontal direction and simultaneously in an upward direction to the first height.

US Pat. No. 10,189,107

SHORT ARC WELDING SYSTEM

ESAB AB, Gothenburg (SE)...

1. A system for controlling a weld-current in a direct current arc welding apparatus for short arc welding comprising:a current regulator included in a voltage feedback loop from a power supply to a welding electrode;
an open circuit detector included in the voltage feedback loop, the open circuit detector being configured to detect that an open circuit state is present and to suppress a feedback error when an open circuit state is detected by the open circuit detector;
a node configured to receive an output voltage of the power supply and to generate a voltage signal derived from the output voltage;
a switch connected between the node and the current regulator; and
a ramp generator arranged to provide current ramps during a short circuit phase at the welding electrode,
wherein the open circuit detector comprises a comparator that receives an open circuit voltage threshold and a signal derived from the output voltage, the open circuit voltage threshold comprising a threshold level above which only the open circuit state is possible, the comparator having an output directly connected to the switch,
wherein the switch is configured to, based on the output of the comparator, connect or disconnect the current regulator to receive the voltage signal from the node.

US Pat. No. 10,189,097

INSERT AND INDEXABLE ROTARY CUTTING TOOL

Mitsubishi Hitachi Tool E...

1. An insert comprising substantially parallelogramatic upper and lower surfaces, a side surface connecting said upper surface and said lower surface, and a screw-receiving hole penetrating from said upper surface to said lower surface;a pair of corner portions of said upper surface having corner cutting edges;
part of a long-side ridgeline and a short-side ridgeline adjacent to said corner cutting edge having a main cutting edge and an auxiliary cutting edge both inclined downward;
said upper surface having rake faces for said main cutting edge and said auxiliary cutting edge;
said side surface having flanks for said main cutting edge and said auxiliary cutting edge;
said main cutting edge being constituted by first to third straight cutting edges;
said first to third straight cutting edges being connected in a bent-line shape with inward obtuse crossing angles when viewed from above, such that said second straight cutting edge is positioned outermost;
a cutting edge angle ?1 between the rake face and flank of said first straight cutting edge, a cutting edge angle ?2 between the rake face and flank of said second straight cutting edge, and a cutting edge angle ?3 between the rake face and flank of said third straight cutting edge meeting the relation of ?1>?2>?3;
said long-side ridgeline having first and second cutting-edge-free connecting ridgeline portions connected to said third straight cutting edge; and
said first connecting ridgeline portion being connected to said third straight cutting edge with an inward obtuse angle when viewed from above.

US Pat. No. 10,189,094

MULTIFUNCTIONAL ADJUSTABLE DRILLING MACHINE

CITIC DICASTAL CO., LTD.,...

1. A multifunctional adjustable drilling machine, comprising supporting leg seats, a frame, a bottom plate, driller supports, driller support index plates, drillers, a compression cylinder bracket, a compression cylinder support, a compression plate, a compression cylinder, motors, belt pulleys, conveying belts, a clamp body and a drill bit guide sleeve assembly, whereinthe supporting leg seats are connected with the frame, the frame being connected with the bottom plate, the bottom plate being connected with the driller supports, the bottom plate being provided with holes and positioning pins matched with the driller supports, angles of the driller support index plates being adjustable, the drillers machine holes in an automobile die casting at different angles, and the compression cylinder bracket and the compression cylinder support being connected to the bottom plate; the compression plate being connected to a piston rod of the compression cylinder, the compression cylinder being arranged on the compression cylinder support, the motors driving the belt pulleys and the conveying belts to rotate, the automobile die casting being positioned by the clamp body, and the compression plate clamping the automobile die casting via the compression cylinder; and the drill bit guide sleeve assembly exerting an effect of preventing the drillers from deviating.

US Pat. No. 10,189,074

RING ROLLING PROCESS AND APPARATUS FOR RING ROLLING

Cambridge Enterprise Limi...

1. A ring rolling process comprising:providing a ring shaped workpiece, the ring shaped workpiece having a principal axis, an inner radial surface, an outer radial surface, a first axial surface and a second axial surface;
subjecting the workpiece to radial pressure between a forming roll acting on the outer radial surface and a mandrel roll acting on the inner radial surface, at a radial roll bite region, wherein:
a first axial roll and a second axial roll are provided at the first axial surface and the second axial surface respectively, to subject the workpiece to axial pressure, the first and second axial rolls being provided at an angular position, measured around the workpiece and with respect to the principal axis, within ±10° of said radial roll bite region;
and, in order to control the cross sectional shape of the workpiece at least one of the following conditions (i) and (ii) applies:
(i) the mandrel roll has a projecting portion for contact with the workpiece, the projecting portion having an axial extent which is smaller than the axial height of the workpiece, the mandrel roll being axially moveable relative to the workpiece during the ring rolling process so that the projecting portion is applied to different axial locations of the workpiece, in order to control the shape applied to the workpiece;
and
(ii) the forming roll has a projecting portion for contact with the workpiece, the projecting portion having an axial extent which is smaller than the axial height of the workpiece, the forming roll being axially moveable relative to the workpiece during the ring rolling process so that the projecting portion is applied to different axial locations of the workpiece, in order to control the shape applied to the workpiece;
and wherein the first and second axial rolls are independently moved to adapt to the changing cross section of the workpiece during forming.

US Pat. No. 10,189,070

ROLLER FOR ROLL FORMING

Victaulic Company, Easto...

1. An apparatus for roll forming a pipe element, said apparatus comprising:an outer roller engageable with an outer surface of said pipe element, said outer roller comprising:
a body rotatable about a first axis of rotation, said body having a perimeter region positioned radially distal to and surrounding said first axis, said perimeter region comprising:
a first face oriented transversely to said first axis;
a second face, contiguous with said first face;
a third face, contiguous with said second face and oriented transversely to said first axis;
a channel positioned in said third face and extending around said perimeter region;
said apparatus further comprising:
an inner roller engageable with an inner surface of said pipe element, said inner roller being rotatable about a second axis of rotation oriented substantially parallel to said first axis;
an actuator for moving said inner and outer rollers toward and away from one another; and
a motor for rotating one of said inner and outer rollers.

US Pat. No. 10,189,067

TOOL HOLDERS USABLE WITH TOOLING HAVING DIFFERENT TANG STYLES AND/OR CONFIGURED WITH MECHANICALLY-ACTUATED CLAMP ASSEMBLY

Wilson Tool International...

1. A tool holder configured for use with tools having different tang styles, the tool holder comprising:a housing;
a mechanism that is mechanically actuatable, the mechanism accessible through an opening defined in the housing; and
a clamp assembly operably coupled to the mechanism and comprising:
a clamp plate; and
one or more clamping fingers;
wherein the clamp plate is defined as a longitudinal body that has an extent spanning across the one or more clamping fingers, the longitudinal body of the clamp plate having an end contacting the one or more clamping fingers, the one or more clamping fingers movable in order to secure tools having different tang styles between the fingers and a stationary wall of the housing, movement of the one or more clamping fingers corresponding to movement of the clamp plate body end which stems from adjustment of the mechanism; and
wherein the clamp plate has at least two differing tolerance areas provided therein to enable different degrees of freedom or play for the clamp plate body end both in direction of corresponding movement of the end and in crosswise direction when securing a tool via the clamp assembly, a first tolerance area comprising a plurality of first slits each defined across the extent of the clamp plate body end and thereby forming a plurality of clamp plate portions in contact with the one or more clamping fingers, a second tolerance area defined across a depth of each of the clamp plate portions.

US Pat. No. 10,189,064

CONTROL SYSTEM AND METHOD FOR TAPERED STRUCTURE CONSTRUCTION

Keystone Tower Systems, I...

1. A system for forming a tapered structure, the system comprising:at least three rolls including at least one bend roll and at least two guide rolls, the at least two guide rolls including rollette banks comprising a plurality of rollettes;
a rollette steering mechanism controllable to steer the plurality of rollettes to change an angle of the plurality of rollettes with respect to a stock material to change a first position of the stock material as the stock material is fed into the at least three rolls;
an infeed actuator controllable to adjust a second position of the stock material as the stock material is fed into the at least three rolls, the stock material forming the tapered structure as the stock material is rolled through the at least three rolls; and
a joining element configured to join edges of the stock material together as the stock material is rolled through the at least three rolls to form the tapered structure;
a model implemented on a computer, the model comprising a sequence of positions and infeed angles of the stock material as the stock material is fed into or through the at least three rolls for forming the tapered structure;
a sensor configured to detect a position of the stock material; and
a controller configured to receive instructions based on the sequence of positions and infeed angles of the model and to receive feedback from the sensor, the controller further configured to selectively send a first control signal to the rollette steering mechanism to steer the plurality of rollettes for changing the first position of the stock material and to selectively send a second control signal to the infeed actuator to adjust the second position of the stock material, wherein each one of the first control signal and the second control signal is based on a combination of the instructions based on the sequence of positions and infeed angles of the model and the feedback from the sensor.

US Pat. No. 10,189,059

DEVICES FOR CROSS BORE SAFEGUARD DURING SEWER SYSTEM CLEANOUTS

Gas Technology Institute,...

1. A sewer system cleanout safety device for cross bore safeguard during sewer system cleanout, said safety device comprising:a housing for placement at a sewer cleanout opening to prevent passage of gas out through the sewer cleanout opening during the sewer system cleanout,
the housing having opposed inner and outer cleanout opening surfaces, and a peripheral surface extending between said inner and outer cleanout opening surfaces, and
the housing having a cavity extending between said inner and outer cleanout opening surfaces to permit passage of a sewer system cleanout implement therethrough, the housing having a cavity lining surface to seal with the sewer system cleanout implement passing therethrough.

US Pat. No. 10,189,048

PEELING METHOD AND PEELING APPARATUS

Semiconductor Energy Labo...

1. A peeling method comprising the steps of:a first step of forming a separation layer over a substrate;
a second step of forming a layer to be separated over the separation layer;
a third step of forming a peeling starting point by separating a part of the layer to be separated from the separation layer;
a fourth step of peeling the layer to be separated from the substrate using the peeling starting point; and
a liquid supplying step of supplying liquid to the peeling starting point,
wherein the fourth step includes a step of heating a first portion of the substrate and a step of cooling a second portion of the layer to be separated,
wherein the first portion includes a portion that is not separated from the layer to be separated after the fourth step, and
wherein the second portion includes a portion separated from the substrate after the fourth step.

US Pat. No. 10,189,030

SHOWER HEAD WITH A TOROIDAL PULSATOR AND A MAGNETIC RING

FTT DOO, (RS)

1. A shower arm connected to a hose by way of a thread, comprising:a body within a shower head including a cover; and
a bell arranged from a bottom side of the shower arm that is connected through a thread with the body, inside of which a chamber includes a torus that moves towards and away from the cover to regulate a pressure and width of a spray of the shower arm, the torus being arranged above a nozzle within the bell, wherein during showering air is suctioned from the chamber through the nozzle and swirled with water to form the spray that exits the bell through the nozzle;
a groove, within the bell, arranged from a bottom side of the bell, into which a ring is provided with circumferentially arranged pins are inserted; and
another groove arranged on the ring of circumferentially arranged pins from the upper side thereof, into which a magnetic ring made of a strip of a rolled flexible material is circumferentially inserted.

US Pat. No. 10,189,028

METHOD AND APPARATUS FOR WASHING AND GRADING AGGREGATE

CDE Global Limited, Cook...

1. An apparatus for washing and grading aggregate comprising a chassis, a first grading screen mounted on the chassis for removing oversize material from a feed material, a first hydrocyclone mounted on the chassis receiving undersize material and water from the first grading screen, a second grading screen mounted on the chassis for producing at least one sand product, the second grading screen receiving an underflow from the first hydrocyclone; a second hydrocyclone mounted on the chassis receiving undersize material and water from the second grading screen, an underflow from the second hydrocyclone being delivered onto the second grading screen, wherein the second grading screen is configurable as a split screen having a longitudinally extending dividing wall separating the grading screen into the first and second screening regions, each region being adapted to produce a separate sand product.

US Pat. No. 10,189,025

CAM ASSEMBLY COMPRISING CYLINDRICAL HOUSING

XG SCIENCES, INC., Lansi...

1. A cam assembly comprising:a solid cylinder having a near end and a distal end and an opening extending from the near end through the distal end;
wherein the opening includes an inset;
wherein the near end is configured at a slight angle from the vertical, the angle comprising less than about 15°;
wherein the opening extending from said near end through said distal end is angled through the cam assembly, the opening beginning at the near end and near a bottom edge of the solid cylinder and terminating through the distal end near a top edge of the solid cylinder.

US Pat. No. 10,189,021

MICROFLUIDIC CHIP, MANUFACTURING METHOD THEREFOR AND ANALYSIS DEVICE USING SAME

NANOBIOSYS INC., Seoul (...

1. A microfluidic chip comprising:a substrate comprising, an inflow part penetrating the substrate in a thickness direction,
an outflow part penetrating the substrate in the thickness direction, and
a fluid channel defined to connect the inflow part and the outflow part and extending in a first direction within the substrate, wherein the thickness direction and the first direction are different from one another; and
a film attached to the substrate and covering at least a portion of at least one of the inflow part, the outflow part, and the fluid channel, the film configured to protect at least one of the inflow part, the outflow part and the fluid channel from the outside;
wherein the film includes a first film attached to a top surface of the substrate and a second film attached to a bottom surface of the substrate;
wherein the fluid channel includes an upper fluid channel formed on a top surface of the substrate; a lower fluid channel formed on a bottom surface of the substrate; and a third fluid channel connecting the upper fluid channel and the lower fluid channel,
wherein a thickness of the at least one film is smaller than a thickness of the substrate.

US Pat. No. 10,189,020

SPECIMEN COLLECTION APPARATUS

Alpha Tec Systems, Inc., ...

1. A sample collection apparatus, comprising:a container having an interior portion configured to contain a sample and an opening to the interior portion, the opening for receiving the sample;
a funnel configured to be secured to the opening of the container, the funnel having a mouth portion and a neck portion depending from the mouth, the neck portion configured to be inserted into the opening of the container; and
a closure assembly including:
a first closure structure configured to releasably seal the opening of the container, the first closure structure including a chamber that is in fluid communication with the interior portion of the container when the opening is sealed by the first closure structure,
a chemical reagent contained within the chamber, and
a second closure structure configured to releasably cover the mouth portion of the funnel, wherein the first closure structure is removably attached to the second closure structure.

US Pat. No. 10,189,017

HONEYCOMB MONOLITH STRUCTURE

YARA INTERNATIONAL ASA, ...

1. A honeycomb monolith structure, comprising:a plurality of cell walls defining a plurality of polygonal channels, the plurality of cell walls and channels extending in parallel along a common direction from an entrance end to an outlet end of the structure in a fluid flow direction and where the channels are open in both ends, wherein a transversal cross section of a polygonal channel has a convex polygon shape, wherein at least 50% of the internal angles between two adjacent walls of the convex polygon are greater than 90 degrees and wherein a cell diameter ratio LL/LS (longest over shortest diameter) is greater than 1.5 and wherein a majority of the channels have the same flow resistance.

US Pat. No. 10,189,004

REACTION CHAMBER FOR A CHEMICAL REACTOR, AND CHEMICAL REACTOR CONSTRUCTED THEREFROM

BAYER AKTIENGESELLSCHAFT,...

1. A reaction chamber for a chemical reactor, comprising:a first casing of the reaction chamber,
a first floor of the reaction chamber connected to the first casing and having an opening located in the floor,
an agitator shaft located in the chamber and having at least one agitator element connected thereto, wherein the agitator shaft, seen in the longitudinal direction, has a beginning and an end,
a removable sleeve having a first open end and an opposing second open end, wherein the second opposing open end projects out of the opening in the first floor of the reaction chamber,
wherein the removable sleeve is arranged in alignment with the axis of rotation of the agitator shaft,
wherein the internal diameter of the removable sleeve is greater than the diameter of the agitator shaft,
wherein the agitator shaft extends through the first open end and the opposing second open end of the removable sleeve out of the reaction chamber and forming a gap between the agitator shaft and the inner wall of the removable sleeve, and,
wherein each of the beginning and end of the agitator shaft is adapted to attach to an end or a beginning of a second agitator shaft, respectively.

US Pat. No. 10,189,002

APPARATUS FOR FLOW-THROUGH OF ELECTRIC ARCS

Magnegas Corporation, Cl...

1. A system for the production of a gas from a fluid, the system comprising:an anode connected to a first polarity of power;
a cathode connected to a second, opposing polarity of power, the cathode separated from the anode by a gap, whereby a voltage differential between the anode and the cathode forms an arc there between;
a sleeve having a bore, the bore surrounding at least the gap between the anode and the cathode, the sleeve comprising of an electrical insulator, the bore forming a venturi that has a wider cross-sectional area at each end of the bore and a narrower cross-sectional area at a location of the gap;
an input port fluidly interfaced to a first end of the bore;
an output port fluidly interfaced to a second end of the bore;
means for flowing the fluid from the input port, through the bore of the sleeve, and out of the output port such that the fluid flows from an area around the anode to an area around the cathode or from the area around the cathode to the area around the anode; and
a vessel body made of a metallic material covering an outer surface of the sleeve;
whereas, at least some of the bi-products that are released from the fluid by the reaction are prevented from accumulating on either the anode or the cathode.

US Pat. No. 10,188,997

SCALLOP SUPPORT DISTRIBUTOR FOR RADIAL FLOW REACTOR

Woven Metal Products, Inc...

1. A support distributor for a scallop for use in a radial flow reactor, comprising an elongated sheet having:(a) a plurality of perforations extending through a thickness thereof, and
(b) at least three edges along a length thereof so as to form a member having at least three support points which engage an inner surface of the scallop.

US Pat. No. 10,188,982

METHOD AND INDUSTRIAL PLANT FOR OBTAINING HELIUM FROM A HELIUM-CONTAINING FEED GAS

LINDE AKTIENGESELLSCHAFT,...

1. A method for obtaining helium from a helium-containing feed gas, said method comprising:feeding the helium-containing feed gas to a prepurifying unit wherein undesirable components are removed from the helium-containing feed gas in a pressure swing adsorption process to obtain a prepurified feed gas;
feeding the prepurified feed gas to a membrane unit connected downstream of the prepurifying unit, said membrane unit having at least one membrane which is more permeable to helium than to at least one further component present in the prepurified feed gas, to produce a pressurized low-helium retentate stream;
feeding said pressurized low-helium retentate stream from the membrane unit to the prepurifying unit; and
displacing helium-rich gas with the aid of the pressurized low-helium retentate stream from an adsorber to be regenerated in the prepurifying unit into an already regenerated adsorber of the prepurifying unit.

US Pat. No. 10,188,979

FILTER WITH OPTIMIZED FLUID FLOWS

Norgren Limited, Staffor...

1. A filter (100) with optimized fluid flows to remove one or more components from a fluid, comprising:a filtering media tube (102) adapted to remove the one or more components from the fluid; and
an inlet cap (104) coupled to the filtering media tube (102), the inlet cap (104) adapted to receive the fluid flow that is substantially transversal to a major axis X of the filter (100), wherein the inlet cap (104) further comprises an inlet baffle (304) adapted to uniformly distribute the fluid to the filtering media tube (102), wherein the inlet baffle comprises a baffle base (402) and a plurality of fins (404, 406, 408).

US Pat. No. 10,188,978

ADHESIVE FLUTE SUPPORT WHILE WINDING FLUTED PACK

Baldwin Filters, Inc., K...

1. A method of forming a filter media pack comprising:winding a continuous strip of fluted filter media about a winding core about a winding axis, the strip of filter media extending between opposed first and second edges and including a plurality of flutes formed by a first sheet operably secured to a corrugated sheet defining a plurality of peaks and valleys, the strip of fluted filter media being wound with the corrugated sheet being adjacent the winding core and radially inward of the first sheet, the strip of fluted filter media defining a feed axis generally parallel to the first and second edges and perpendicular to the winding axis, the winding core having opposed first and second sides extending generally parallel to the winding axis, the winding core defining opposed first and second faces defining a minor axis therebetween, the first and second sides extending generally between the first and second faces and defining a major axis therebetween; and
applying a first support bead between the winding core and the strip of filter media, the first support bead extending generally perpendicular to the first and second edges of the strip of filter media and parallel to the winding axis, the first support bead being located proximate the first side of the winding core, the first support bead filling the cross-section of at least two valleys on opposite sides of a peak of the corrugated sheet proximate the first side of the winding core, the first support bead distributing radially directed loading applied to the corrugated sheet from the first side of the winding core due to tension in the strip of filter media during winding.

US Pat. No. 10,188,958

AUTOMATED DETECTION OF SURFACE LAYOUT

Anki, Inc., San Francisc...

1. A system comprising:a surface having a layout, and comprising a plurality of machine-readable codes, each machine-readable code identifying at least one characteristic of a portion of the surface;
a plurality of mobile agents configured to explore the surface contemporaneously with one another, each mobile agent comprising:
a propulsion mechanism, configured to impart motive force to cause the mobile agent to travel along the surface;
a sensor, configured to detect the machine-readable codes as the mobile agent travels along the surface;
a mobile wireless transceiver, configured to transmit at least one signal representing the detected machine-readable codes; and
a microcontroller, operatively coupled to control the operation of the propulsion mechanism, the sensor, and the mobile wireless transceiver; and
a host device, comprising:
a wireless transceiver, configured to receive signals representing detected machine-readable codes from the mobile agents;
a processor, operatively coupled to the wireless transceiver, configured to determine the layout of the surface by merging information from the signals received from at least two of the mobile agents; and
a storage device, operatively coupled to the wireless transceiver, configured to store a virtual representation of the surface based on the determined layout;
wherein the host device is configured to implement an entertainment activity for the plurality of mobile agents based on the virtual representation.

US Pat. No. 10,188,952

METHOD FOR DYNAMICALLY MAPPING SERVERS

Controlled Protocols, Inc...

1. A non-transitory computer readable medium including a program of instructions for dynamically mapping a plurality of servers that when executed by a computer performs the steps of:defining a three dimensional area of a virtual space divided into independently storable blocks with an integral coordinate system by providing coordinate addresses that have an X, Y and Z component, wherein each component includes a summary address portion and an internal address portion;
mapping coordinate addresses that represent a position within the virtual space to server coordinates, wherein the coordinate address includes an embedded and freely assignable server address so that each block can be transferred and independently stored on one or more of the plurality of servers;
adding a block to any one of the plurality of servers to expand beyond the defined three dimensional area; and
dynamically re-mapping the coordinate address to reflect the new server coordinates of the added block.

US Pat. No. 10,188,934

ICE SKATE AND RUNNER THEREFOR

SPORT MASKA INC., Montre...

1. An ice skate comprising:a boot adapted for receiving therein a foot of a wearer of the skate;
a holder mounted to a sole of the boot and having at least one attachment point thereon; and
a runner mounted to the holder and secured in place thereon via the at least one attachment point, the runner being entirely metal and extending a length along a longitudinal axis between a front end and an opposed rear end of the runner, the runner having a height extending between an ice-contacting portion for engaging an ice surface and an opposed upper portion of the runner, opposed outer and inner side surfaces of the runner defining a datum runner thickness extending therebetween, and one or more regions of reduced thickness in the runner that are recessed inwardly from at least one of the outer and inner side surfaces thereof, the one or more regions having a local thickness less than the datum runner thickness, at least one of the one or more regions of reduced thickness having a closed periphery being entirely surrounded by regions having a thickness greater than the local thickness.

US Pat. No. 10,188,932

BASEBALL AND SOFTBALL TOURNAMENT SYSTEM

1. A method of conducting a baseball tournament between baseball teams, the baseball tournament having a contest stage and an elimination stage, an electronic Data And Predictability Probability (“DAPP”) System used to determine the outcome of each instance of a player at-bat, the baseball teams made of players, the method comprising:a. matching a first set of baseball teams into opposing pairs of teams;
b. playing the opposing pairs of teams of the first set of baseball teams against one-another in a set of contest games;
i. the contest games using a pitcher selected from the group of: batting tee, soft toss, coach pitching, pitching machine, or a team-designated pitcher;
ii. during play, the DAPP System identifying each batter as he prepares to bat;
1. the batter identified using player order, or input via a field judge input or a coach input;
2. a player data file opened for the identified batter, the DAPP System prepared to save data to the player data file;
iii. after the ball is hit by the batter, the DAPP System taking sensor input from one or more sensors;
1. the DAPP System using the sensor input to determine ball trajectory, spin, and velocity;
2. the DAPP System saving the ball trajectory, spin, and velocity data in the player data file;
3. the DAPP System using input from one or more sensors to determine balls, strikes, and the probability of base hits;
iv. repeating step b, each time removing the losing team from the tournament until a predetermined number of teams remains, the predetermined number of teams forming a second set of teams;
c. matching the second set of baseball teams into opposing pairs of teams;
d. playing the second set of baseball teams against one-another in elimination games;
i. the elimination games using a second pitcher, the second pitcher selected from the group of: batting tee, soft toss, coach pitching, pitching machine, or a team-designated pitcher;
ii. during play, the DAPP System identifying each batter as he prepares to bat;
1. the batter identified using player order, or input via a field judge input or a coach input;
2. a player data file opened for the identified batter, the DAPP System prepared to save data to the player data file;
iii. after the ball is hit by the batter, the DAPP System taking sensor input from one or more sensors;
1. the DAPP System using the sensor input to determine ball trajectory, spin, and velocity;
2. the DAPP System saving the ball trajectory, spin, and velocity data in the player data file;
3. the DAPP System using input from one or more sensors to determine balls, strikes, and the probability of base hits;
iv. repeating step d until only a single team remains;
v. outputting the outcome to one or more displays.

US Pat. No. 10,188,930

COMBINATORY SCORE HAVING A FITNESS SUB-SCORE AND AN ATHLETICISM SUB-SCORE

NIKE, Inc., Beaverton, O...

1. A computer-implemented method comprising:providing first instructions to a user to perform a first athletic movement;
receiving, from a sensor, first activity data representing the first athletic movement;
calculating with a processor, based on the first activity data, a first combinatory fitness-athleticism score;
providing, in response to a triggering event, second instructions to the user to perform a second athletic movement;
receiving, from the sensor, second activity data representing the second athletic movement;
calculating, with the processor, based on the second activity data, a second combinatory fitness-athleticism score,
wherein the first and the second combinatory fitness-athleticism scores each comprise a fitness sub-score and a separate athleticism sub-score of the user,
wherein the fitness sub-score is calculated, by the processor, using one or more of an endurance fitness attribute, a flexibility fitness attribute and a strength fitness attribute of the user, and
wherein the athleticism sub-score is calculated, by the processor, using one or more of a speed athleticism attribute, an agility athleticism attribute, a reaction athleticism attribute, a power athleticism attribute and a balance athleticism attribute of the user.

US Pat. No. 10,188,927

CONVERTIBLE GOLF ALIGNMENT AND MEASUREMENT DEVICE

1. A golf device comprising:a first elongated portion including a hollow portion, a first end, and a second end, wherein the first elongated portion and the hollow portion are straight;
a second elongated portion including a hollow portion, a first end, and a second end, wherein the second elongated portion and the hollow portion are straight;
a hinge securing the first end of the first elongated portion and the first end of the second elongated portion, wherein the first elongated portion and the second elongated portion are configured to form a 180 degree angle at the hinge in a first configuration and a 90 degree angle at the hinge in a second configuration; and
a first arch portion and a second arch portion, which are made from a flexible material, wherein the first arch portion is concealed inside the hollow portion of the first elongated portion and includes a first slideable end and a second end, wherein the first slideable end of the first arch portion includes a first keeper which is slideably engageable inside the first elongated portion in a lengthwise direction of the first elongated portion until reaching a first stop at the second end of the first elongated portion, and wherein the second arch portion is concealed inside the hollow portion of the second elongated portion and includes a first slideable end and a second end, wherein the first slideable end of the second arch portion includes a second keeper which is slideably engageable inside the second elongated portion in a lengthwise direction of the second elongated portion until reaching a second stop at the second end of the second elongated portion, wherein the second end of the second arch portion is configured to couple to the second end of the first arch portion, wherein the first and second arch portions are exposed outside of the hollow portions as a result of the first and second arch portions being pulled from inside the hollow portions from the second ends of the first and second elongated portions in the lengthwise direction and wherein the first and second arch portions form an arch from the second end of the first elongated portion to the second end of the second elongated portion when the first slideable end reaches the second end of the first elongated portion, when the second slideable end reaches the second end of the second elongated portion, when the first arch portion from the first elongated portion and the second arch portion from the second elongated portion are coupled together at the second ends of the first and second arch portions, and when the first elongated portion and the second elongated portion form the 90 degree angle at the hinge, the arch having a constant radius with a length from the hinge to the first and second arch portions.

US Pat. No. 10,188,920

SCORING DEVICE FOR SCORING A SNOWBALL FIGHT

Peter Moloney, St. Paul,...

1. A scoring device to be worn by a person for scoring a snowball fight, the device comprising:a target portion including:
a target,
a permeable layer spaced apart from the target,
an interior region, including a scoring chamber, positioned between the permeable layer and the target, the interior region being substantially continuous without any openings; and
the scoring chamber portion positioned at the bottom of the interior region when the scoring device is worn by the person, the scoring chamber portion arranged to accumulate and store snow falling from the interior region
the scoring device except the permeable layer being substantially fluid-tight such that when snow passes through the permeable layer, snow is collected in the scoring chamber and prevented from leaving the scoring device.

US Pat. No. 10,188,915

GOLF CLUB HEAD

TAYLOR MADE GOLF COMPANY,...

1. A golf club head, comprising:a body, defining an interior cavity and comprising:
a sole portion, positioned at a bottom region of the golf club head;
a crown portion, positioned at a top region of the golf club head;
a skirt portion, positioned around a periphery of the golf club head between the sole portion and the crown portion;
a forward region;
a rearward region, opposite the forward region;
a heel region; and
a toe region, opposite the heel region; and
a face portion, coupled to the body at the forward region of the body and comprising a strike plate; and
at least one stiffener comprising a discrete mass of polymeric material within the interior cavity and directly coupled to the face portion at a location with an x-axis coordinate, of a club head origin coordinate system of the golf club head, greater than 20 mm and less than 50 mm or greater than ?50 mm and less than ?20 mm, wherein the polymeric material of the at least one discrete mass has a hardness equal to or greater than about Shore 10D;
wherein:
the golf club head further comprises a retaining wall, coupled to the sole portion, protruding uprightly from the sole portion, and extending lengthwise in a heel-to-toe direction;
the discrete mass of polymeric material is coupled to the retaining wall and interposed between the retaining wall and the face portion;
the golf club head further comprises a slot, formed in the sole portion and extending lengthwise from the heel region to the toe region; and
the retaining wall forms part of the slot.

US Pat. No. 10,188,914

GOLF CLUB HEAD

Bridgestone Sports Co., L...

1. A golf club head comprising a crown portion and a face portion, wherein the crown portion includes a first protruding portion arranged on a side of the face portion and extending from an upper end of the face portion to a back side, a second protruding portion arranged on the back side to be adjacent to the first protruding portion, and a valley portion formed where the first and second protruding portions are connected to one another, the second protruding portion has a convex-curved outer surface extending from the valley portion to a back side end of the crown portion, a width of the first protruding portion in a face-back direction on a plane passing through a face center of the face portion and extending in a vertical direction is smaller than a width of the second protruding portion in the face-back direction, and a protruding height of the second protruding portion is larger than a protruding height of the first protruding portion, wherein curved outer surfaces of the first and second protruding portions abut to form an inflection at the valley portion.

US Pat. No. 10,188,893

HANDHELD WEIGHTED EXERCISING APPARATUS

Mitz Fitness Limited, Ch...

1. An exercise apparatus comprising:a housing configured to receive a hand of a user and extend, in use, up to a wrist area of the user, the housing comprising an upper surface, a lower surface and sides between the upper surface and the lower surface, wherein the housing incorporates a plurality of vents, the plurality of vents located on the upper and the lower surfaces of the housing;
an opening within the housing for receiving the hand of the user;
a handle inside the housing, wherein the handle is disposed within the housing closer to an end of the housing which opposes the opening than to the opening; and
at least one weight provided by, configured within or disposed in relation to the housing and/or the handle,
wherein at least 30% of the area of the upper and the lower surfaces of the housing is the plurality of vents,
whereby in use, the user grips the handle with the hand inside the housing, to lift the at least one weight to perform exercises with the exercise apparatus.

US Pat. No. 10,188,885

HIGH NITROGEN AND OTHER INERT GAS ANTI-CORROSION PROTECTION IN WET PIPE FIRE PROTECTION SYSTEM

Engineered Corrosion Solu...

1. A method of operating a wet pipe fire protection sprinkler system having a pipe network, a source of water for the pipe network, at least one sprinkler head connected with the pipe network, a venting assembly configured to vent gas and not water from said pipe network, and a nitrogen source connected with the pipe network, the method comprising:supplying nitrogen gas from the nitrogen source to the pipe network to increase a pressure in the pipe network above atmospheric pressure;
supplying water to the pipe network, thereby filling the pipe network with water and compressing nitrogen gas in the pipe network; and
discharging gas including nitrogen gas from the pipe network via the venting assembly while supplying water to the pipe network.

US Pat. No. 10,188,874

THREE DIMENSIONAL LOCALIZATION AND TRACKING FOR ADAPTIVE RADIATION THERAPY

Elekta, Inc., Atlanta, G...

1. A method for locating a three-dimensional (3D) target in a region of interest in a patient undergoing image-guided radiation therapy, the method comprising:receiving, from an image acquisition device, a two-dimensional (2D) slice of the region of interest, the 2D slice being based on a direction of motion with respect to the target in the patient;
receiving an adaptive filter model for a region of interest in the patient, the adaptive filter model being based on the target to be located;
generating a 2D patch for each 2D slice, where each 2D patch includes an associated offset value reflecting a distance between the target and a position in the corresponding 2D slice;
determining, by a processor, a correlation between the adaptive filter model and the 2D slice;
determining, by the processor, a 2D location of the target on the 2D slice based on the adaptive filter model and the determined correlation; and
estimating, by the processor, a 3D location of the target within the patient based on the offset value and the 2D slice having the determined 2D location of the target.

US Pat. No. 10,188,869

HARDWARE/SOFTWARE INTEGRATED DESIGN FOR A 3D TREMOR DETECTOR USING TMS IN PARKINSON'S DISEASE AND RELATED DISORDERS

The Florida International...

1. A system comprising:a Transcranial Magnetic Stimulation (TMS) machine;
a Transcranial Stimulation Biofeedback (TSB) Detector device;
a software component comprising instructions stored on one or more non-transitory computer readable media that, when executed by a computing device, direct the computing device to:
receive waveforms from the TSB Detector device;
compute a determination factor based on the waveforms; and
when the determination factor is outside a predetermined range, send an abort signal such that the TMS machine ceases providing magnetic stimulation, and when the determination factor is not outside the predetermined range, allow the TMS machine to continue providing magnetic stimulation,
the TSB Detector device comprising:
a three-axis accelerometer sensor configured to provide three-dimensional signals;
a three-channel analog amplifier configured to receive the three-dimensional signals; and
a capacitor and a resistor connected between the three-axis accelerometer and the three-channel analog amplifier and configured to generate a cut-off frequency, and
three-dimensional tremor signals detected by the TSB Detector device being synchronized with the TMS machine via a dual communication link.

US Pat. No. 10,188,859

PORTABLE ONE-PIECE THERAPEUTICAL APPARATUS WITH DUAL HEATING AND LOW-FREQUENCY TREATMENT FUNCTIONS

HIVOX BIOTEK INC., New T...

1. A portable one-piece therapeutical apparatus with dual heating and low-frequency treatment functions, comprising:a main unit, being in a one-piece injection molded form and including a main body portion and a patch portion extended separately and outwardly from both sides of the main body portion, and the main body portion having an accommodating unit, and the accommodating unit having an accommodating space;
a control means, installed in the accommodating space, and including a printed circuit board assembly, having an operating component installed on the printed circuit board assembly for controlling heating low-frequency pulses;
two heating means, each heating means is in the position of a middle layer of each patch portion, and each heating means has a heating plate, and each heating plate has a printed silver paste heating circuit pattern, and the heating circuit pattern includes an electrical contact terminal electrically coupled to the printed circuit board assembly for producing a heating effect, and a diffuser is attached to the top of the heating circuit pattern, wherein the diffuser is provided for diffusing the heat generated by the heating circuit pattern and preventing the heat from being concentrated at a position to facilitate the heating operation;
two low-frequency electrode layers, each low-frequency electrode layer disposed under each heating means and includes a base layer made of a PET material; two low-frequency circuit patterns, each low-frequency circuit pattern installed under the base layer, and including a low-frequency circuit contact terminal coupled to the printed circuit board assembly and a middle portion disposed at the middle portion of the low-frequency circuit pattern, and the low-frequency circuit contact terminal being electrically coupled to the printed circuit board assembly, wherein the low-frequency circuit pattern under the base layer is printed to form a conducting circuit; two distribution layers, disposed under each low-frequency circuit pattern, wherein the distribution layer under the low-frequency circuit pattern and the base layer is formed by an insulated oil printing process, and the purpose of the distribution layer is to prevent any unnecessary electrode output in order to distribute current uniformly, the bottom of the distribution layer further has a carbon ink layer attached and configured to contact skin for performing a low frequency output of the low-frequency electrode layer;
a battery, installed in the accommodating space, and directly and electrically coupled to the printed circuit board assembly for supplying power to the therapeutical apparatus.

US Pat. No. 10,188,857

LEAD IDENTIFICATION SYSTEM

Nuvectra Corporation, Pl...

1. A method, comprising:inserting an epidural needle into a patient, the epidural needle having a stylet;
removing the stylet from the epidural needle;
inserting an implantable lead through the epidural needle, the implantable lead having a plurality of contacts;
positioning the implantable lead; and
attaching a removable lead indicator to the epidural needle.

US Pat. No. 10,188,856

IMPLANTABLE DEVICE FOR PROVIDING ELECTRICAL STIMULATION OF CERVICAL VAGUS NERVES FOR TREATMENT OF CHRONIC CARDIAC DYSFUNCTION

Cyberonics, Inc., Housto...

1. A vagus nerve neurostimulator for treating chronic cardiac dysfunction, comprising:an implantable neurostimulator comprising:
a pair of helical electrodes;
a nerve stimulation therapy lead electrically coupled to the pair of helical electrodes;
a pulse generator configured to deliver electrical therapeutic stimulation comprising a stimulation waveform applied to both of the helical electrodes via the nerve stimulation therapy lead, the stimulation waveform comprising a form that causes propagation of action potentials in both an afferent direction and an efferent direction within neuronal fibers of a cervical vagus nerve; and
a recordable memory within which is stored stimulation parameters configured to define a periodic duty cycle comprising a percentage of time that the pulse generator delivers the electrical therapeutic stimulation,
wherein the periodic duty cycle is between a lower predefined percentage and an upper predefined percentage,
wherein the pulse generator is further configured to operate under the stimulation parameters stored in the recordable memory.

US Pat. No. 10,188,854

MICROELECTRODE AND MULTIPLE MICROELECTRODES

NEURONANO AB, (SE)

1. An array of medical microelectrodes comprising at least two medical microelectrodes, each medical microelectrode of the at least two medical microelectrodes is configured for insertion into soft tissue, each medical microelectrode comprising:an electrically conducting elongate electrode body including a first proximal end, and a second distal end, the electrode body comprising:
a tip section extending from the distal end;
a main body section extending in a proximal direction from the tip section,
wherein the tip section and the main body section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid;
a dissolution retarding layer on the first electrode matrix element; and
a second electrode matrix section element, different from the first electrode matrix section element, the second electrode matrix section element positioned such that the first electrode matrix section element is positioned between the second electrode matrix section element and the electrode main body,
wherein at least one the first electrode matrix element and the second electrode matrix element comprises a drug configured to be released upon dissolution or biodegradation of the first electrode matrix element, and
wherein the at least two microelectrodes are positioned interspaced on a face of a solid support.

US Pat. No. 10,188,851

TTFIELD TREATMENT WITH OPTIMIZATION OF ELECTRODE POSITIONS ON THE HEAD BASED ON MRI-BASED CONDUCTIVITY MEASUREMENTS

NOVOCURE LIMITED, St. He...

1. A method of optimizing positions of a plurality of electrodes placed on a subject's body, wherein the electrodes are used to impose an electric field in target tissue within an anatomic volume, the method comprising the steps of:obtaining electrical conductivity or resistivity measurements in the anatomic volume;
generating a 3D map of electrical conductivity or resistivity of the anatomic volume directly from the obtained electrical conductivity or resistivity measurements, without segmenting the anatomic volume into tissue types;
identifying a location of the target tissue within the anatomic volume; and
determining positions for the electrodes based on the 3D map of electrical conductivity or resistivity generated in the generating step and the location of the target tissue identified in the identifying step.

US Pat. No. 10,188,848

NEEDLELESS VALVE INFECTION PREVENTION AND PRE-OPENING DEVICE

CareFusion 303, Inc., Sa...

1. A device for use with a female needleless connector, the device comprising:a housing comprising:
a chamber having a proximal wall;
a side-wall extending from the proximal wall toward a distal opening configured to fit over a proximal end of the female needleless connector; and
an elongate finger extending within the chamber from the proximal wall toward the distal opening,
wherein an outer surface of the elongate finger comprises an undercut that extends from the proximal wall toward the distal end of the elongate finger, and
wherein the side-wall extends beyond a distal end of the elongate finger such that the elongate finger extends into and opens a fluid path through the female needleless connector when the distal opening is distally advanced over the female needleless connector.

US Pat. No. 10,188,827

DISTAL CLOSING CATHETERS AND METHODS FOR SAME

Uropharma Limited, Mount...

1. A urinary catheter for insertion into a urinary bladder of a subject, comprising:a drainage tube extending from a drainage opening adjacent a distal end of the catheter to a drainage outlet adjacent a proximal end of the catheter, wherein the proximal end of the catheter is configured for positioning outside the subject with the distal end of the catheter within the subject;
a closure member located adjacent the distal end of the catheter and movable within said drainage tube between an open position and a closed position:
in the open position said drainage opening is aligned with an aperture of the closure member, and
in the closed position the drainage opening is misaligned with the aperture of the closure member and the drainage tube is closed adjacent to the distal end of the catheter;
an actuator coupled with the closure member and operable from the proximal end of the catheter, the actuator configured to remotely move said closure member adjacent the distal end between said open and closed positions; and
an instillation lumen extending from an instillation port adjacent the proximal end of the catheter to an instillation outlet adjacent the distal end of the catheter, the instillation outlet is configured to discharge into the urinary bladder, wherein the instillation lumen is isolated from the drainage tube and the closure member.

US Pat. No. 10,188,824

AEROSTASIS IN PULMONARY SURGERY

THE ARIZONA BOARD OF REGE...

1. A method for preventing air leaks from a serosal tissue wound, comprising:providing a device comprising a dispensing apparatus and a delivery apparatus in fluid communication with said dispensing apparatus;
rapidly warming frozen aliquots of fibrinogen and thrombin from about 0° C. to about 37° C. in about 3 minutes or less;
after fibrinogen aliquots and thrombin aliquots are rapidly warmed to about 37° C., the fibrinogen and thrombin aliquots are provided within about 5 minutes from said dispensing apparatus to said delivery apparatus;
mixing a fibrinogen stream and a thrombin stream in a pressurized gas stream, said pressurized gas stream having a pressure of 50 psi or greater;
generating a fibrin-forming foam; and
directing said fibrin-forming foam onto said serosal tissue wound.

US Pat. No. 10,188,822

GAS DELIVERY DEVICE AND SYSTEM FOR USE IN MAGNETIC RESONANCE IMAGING

Mallinckrodt Hospital Pro...

1. A nitric oxide delivery system for providing inhaled nitric oxide (iNO) to a patient situated in an MRI suite, the nitric oxide delivery system comprising:a patient connector;
a source of nitric oxide gas;
a length of an iNO delivery tube;
a source of breathing gas;
a monitoring control circuit;
a delivery control circuit;
a signal processor including a corrective signal processing algorithm comprising determining an inverse of the distortion transfer function produced by the length of iNO delivery tube; determining a ventilator flow profile of individual breaths performed on a continuing basis during ventilation; convolving the inverse of a distortion transfer function with a predicted breath flow profile; and verifying a consistent ventilator flow profile; and
an injector module fluidly connected to the source of nitric oxide, the source of breathing gas and the delivery control circuit; said injector module being located outside an iso-gauss safety line.

US Pat. No. 10,188,816

SYSTEM FOR REMOVING INFECTIOUS SECRETIONS

Flosure Technologies LLC,...

1. A method of decreasing a probability of Ventilator Associated Pneumonia, said method comprising the steps of:a. inserting a tracheal/endotracheal device into the trachea of a patient;
b. inflating a balloon that surrounds a segment of said tracheal/endotracheal device,
whereby a segment of said tracheal/endotracheal device is disposed inferior to said balloon and a segment of said tracheal/endotracheal device is disposed superior to said balloon
c. delivering a mist through a port in said tracheal/endotracheal device, said mist being released in and delivered to the trachea, in an area that is inferior to said balloon;
d. simultaneously with the delivery step c, providing suction to capture mist or fluid from said inferior area in said trachea; and
e. delivering captured mist or fluid to a collection vessel that is disposed outside of said trachea,
wherein the provision of suction commences prior to the delivery of the mist and wherein the delivery of the mist is synchronized with the expulsion of air from the patient's lungs.

US Pat. No. 10,188,815

LARYNGEAL MASK WITH RETRACTABLE RIGID TAB AND MEANS FOR VENTILATION AND INTUBATION

Medcom Flow S.A., Barcel...

1. A laryngeal mask comprising the following elements:a rigid tube essentially in the form of a “J”, which has a lengthwise opening along its entire length; and
a flexible tube, also essentially in the form of a “J”, configured to be housed in the lengthwise opening of the rigid tube and separable from the rigid tube, and terminating at its distal end with an inflatable or gel laryngeal ring;
wherein the rigid tube terminates at its distal end with a rigid tongue-shaped tab, and wherein the flexible tube terminates at its distal end with a flexible sleeve configured to house the rigid tongue-shaped tab of the rigid tube in the interior of the flexible sleeve when the rigid tube and the flexible tube are coupled.

US Pat. No. 10,188,795

BLOOD GLUCOSE CONTROL SYSTEM

Trustees of Boston Univer...

1. A sensor-driven glucose control system, comprising:an insulin delivery device operative in response to an insulin dose control signal to infuse insulin into the subject; and
a controller operative to generate the insulin dose control signal by:
(1) continually administering priming doses of insulin at respective times, each priming dose being of a respective amount and having a prescribed interval of action;
(2) receiving information regarding total amounts of insulin administered during the prescribed intervals of action, each total amount including an aggregation of total doses administered in response to a glucose level signal; and
(3) automatically adapting the amounts of the priming doses in response to a mathematical relationship, over respective periods each spanning multiple prescribed intervals of action, between the amounts of the priming doses and the total amounts of insulin administered during the prescribed intervals of action.

US Pat. No. 10,188,788

SYSTEM AND METHODS FOR MEDICAMENT INFUSION

Medirio S.A., Visp (CH)

1. A system for trans-dermal delivery of a dose of a medicament, comprising a delivery device and a separate hand-held drive device, whereinthe delivery device is configured to be placed in dermal contact with a patient, the delivery device comprising
a reservoir for holding the medicament to be delivered,
a trans-dermal injection element for delivering the dose of the medicament to the patient,
a control unit for controlling the transformation of external energy transferred from the hand-held drive device to the delivery device into a pumping force and for allowing a specific dose of the medicament to be pumped when the dose is requested, the control unit comprising
one or more rotors and/or one or more axial pump elements for transforming rotational and/or axial force into the pumping force, and
at least one safe-lock mechanism for preventing mechanical action to cause rotation of the at least one or more rotors and/or movement of the one or more axial pump elements thereby preventing passage of the medicament from the reservoir to the trans-dermal injection element unless a dose is requested;
the separate hand-held drive device being configured to be placed temporarily in proximity to the delivery device when a dose of medicament is required, the hand-held drive device comprising an activation unit for activating the control unit of the delivery device, the activation unit comprising
at least one unlocking element to provide energy to the control unit of the delivery device for unlocking the at least one safe-lock mechanism and a drive unit to provide energy for any of the one or more rotors and/or one or more axial pump elements of the control unit, only when the separate hand-held drive device is in proximity to the delivery device, and
wherein the hand-held drive device comprises a sensor capable of detecting the amount of energy being transferred and/or transformed into pumping force.

US Pat. No. 10,188,779

IMPLANTABLE PUMP SYSTEM HAVING AN UNDULATING MEMBRANE WITH IMPROVED HYDRAULIC PERFORMANCE

CorWave SA, Clichy (FR)

1. An implantable blood pump system comprising:a housing having an inlet and an outlet and configured to be implanted at a patient's heart;
a membrane disposed within the housing;
a skirt disposed within the housing and coupled to the membrane, the skirt sized and shaped to extend toward the inlet and to curve toward the outlet; and
an actuator disposed within the housing, the actuator configured to cause the membrane to reciprocate and deform in a wave-like manner,
wherein during operation blood enters the inlet, flows toward the skirt which guides the blood towards the membrane, and is propelled across the membrane to the outlet.

US Pat. No. 10,188,767

SCENT PRESENTATION METHOD, SCENT PRESENTATION APPARATUS, AND OLFACTION IMPROVING APPARATUS

KEIO UNIVERSITY, Tokyo (...

1. An olfaction improvement method comprising:determining a detection threshold at which a test subject is able to detect a scent selected from among a plurality of scents by
presenting the scent by pulse ejecting the scent for a specified time interval between from about 100 ms to about 300 ms to vary the intensity of the scent,
detecting an operation of a terminal device by the test subject upon detection of the scent by the test subject, and
setting the intensity of the scent detected by the test subject over at least two consecutive trials as the detection threshold of the test subject for each scent from among the plurality of scents, wherein the plurality of scents are selected and presented in a predetermined sequence;
generating a random number to randomly determine a presentation sequence of the plurality of scents;
determining presentation conditions that include the intensity of the scent and the pulse ejection duration of the scent based on the detection threshold of the test subject;
presenting the scent through pulse ejection based on the determined presentation condition; and
altering the presentation conditions by reducing the intensity of the scent, the pulse ejection duration of the scent, or both the intensity of the scent and the pulse ejection duration of the scent relative to the detection threshold of the test subject when presenting the scent at a subsequent time, wherein
the scent is pulse ejected by a fluid ejection device.

US Pat. No. 10,188,766

PURIFIED HYDROGEN PEROXIDE GAS MICROBIAL CONTROL METHODS AND DEVICES

Synexis LLC, Kansas City...

1. A diffuser apparatus for producing non-hydrated purified hydrogen peroxide gas (PHPG) from humid ambient air-comprising:(a) an air distribution mechanism providing an airflow of said humid ambient air;
(b) a source of ultraviolet light; and
(c) a metal, or metal oxide catalyst on a thin, air-permeable substrate structure having a surface,
wherein said air flow is through; said surface and has a residence time on said air-permeable substrate structure of less than a second, wherein said non-hydrated purified hydrogen peroxide gas comprises 0.015 ppm of ozone or less and is directed out of said diffuser apparatus and into an environment when said apparatus is in operation.

US Pat. No. 10,188,763

APPARATUS AND METHOD FOR SANITIZING STETHOSCOPE HEADS

1. A method for santizing a stethoscope head having a diaphragm and a bell, the method comprising:providing an apparatus configured to apply a sanitizing fluid to the stethescope head, the apparatus comprising:
a housing shaped to retain a sanitizing fluid; and
an applicator pad connected to the housing and in selective fluid communication with the sanitizing fluid, the applicator pad comprising a raised portion having a substantially hemi-spherical shape configured to at least partially extend into an interior region of the bell of the stethoscope head when the bell is placed against the raised portion;
dispensing the santizing fluid from the housing and unto the applicator pad, the applicator pad formed from a porous, absorbent material that absorbs the sanitizing fluid when the sanitizing fluid dispenses out of the housing and onto the applicator pad; and
applying the sanitizing fluid to the bell of the stethoscope head by placing the interior region of the bell against the raised portion of the applicator pad.

US Pat. No. 10,188,754

COMPOSITIONS AND METHODS FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) BASED MAGNETIC RESONANCE IMAGING (MRI)

The Johns Hopkins Univers...

1. A method of producing a magnetic resonance (MR) image of a target, comprising:introducing a magnetic resonance imaging (MRI) contrast agent to the target; and
imaging the target using a Chemical Exchange Saturation Transfer (CEST) or frequency labeled exchange (FLEX) based MRI technique to produce the MR image of the target,
wherein the MRI contrast agent is a compound of Formula (I), or a salt or stereoisomer thereof:
wherein:R1 and R2 are each independently H, SR, phosphorus, alkyl, amino, alkoxyl, cycloalkyl, arylalkyl, cycloalkyl-alkyl, heterocyclic, heteroaryl-alkyl, aryl, heteroaryl, —C(O)-alkyl, or —C(O)O-alkyl; or R1, and R2, taken together with the bonds they are attached to, form an aryl or heteroaryl group; wherein said amino, alkyl, alkoxyl, cycloalkyl, arylalkyl, cycloalkyl-alkyl, heterocyclic, heteroaryl-alkyl, aryl, heteroaryl, —C(O)-alkyl, or —C(O)O-alkyl moiety is optionally substituted;
when Y is O, R3 is H, and when Y is NR5, R3 is selected from the group consisting of H, phosphorus, alkyl, —S(O)2R, cycloalkyl, arylalkyl, cycloalkyl-alkyl, heterocyclic, heteroaryl-alkyl, aryl, heteroaryl, —C(O)-alkyl, or —C(O)O-alkyl, wherein said alkyl, cycloalkyl, arylalkyl, cycloalkyl-alkyl, heterocyclic, heteroaryl-alkyl, aryl, heteroaryl, —C(O)-alkyl, or —C(O)O-alkyl moiety is optionally substituted, provided that at least one of R3 and R5 is H;
R4 is H, phosphorus, halogen, SR, hydroxyl, amino, alkoxyl, alkyl, cycloalkyl, arylalkyl, cycloalkyl-alkyl, heterocyclic, heteroaryl-alkyl, aryl, heteroaryl, —C(O)-alkyl, or —C(O)O-alkyl, wherein said alkyl, amino, alkoxyl, cycloalkyl, arylalkyl, cycloalkyl-alkyl, heterocyclic, heteroaryl-alkyl, aryl, heteroaryl, —C(O)-alkyl, —C(O)O-alkyl moiety is optionally substituted; and
X is O, NR5, alkyl, or S;
Y is O or NR5; and
wherein each R5 is independently selected from the group consisting of H, alkyl, cycloalkyl, arylalkyl, cycloalkyl-alkyl, heterocyclic, heteroaryl-alkyl, aryl, heteroaryl, —C(O)— alkyl, or —C(O)O-alkyl, wherein said alkyl, cycloalkyl, arylalkyl, cycloalkyl-alkyl, heterocyclic, heteroaryl-alkyl, aryl, heteroaryl, —C(O)-alkyl, or —C(O)O-alkyl moiety is optionally substituted.

US Pat. No. 10,188,746

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

MEDIMMUNE LIMITED, Cambr...

1. A conjugate of formula (A):
and salts and solvates thereof, wherein:
D represents either group D1 or D2:

the dotted line indicates the optional presence of a double bond between C2 and C3;
when there is a double bond present between C2 and C3, R2 is selected from the group consisting of:
(ia) C5-10 aryl group, optionally substituted by one or more substituents selected from the group comprising: halo, nitro, cyano, ether, carboxy, ester, C1-7 alkyl, C3-7 heterocyclyl and bis-oxy-C1-3 alkylene;
(ib) C1-5 saturated aliphatic alkyl;
(ic) C3-6 saturated cycloalkyl;
(id)
wherein each of R31, R32 and R33 are independently selected from H, C1-3 saturated alkyl, C2-3 alkenyl, C2-3 alkynyl and cyclopropyl, where the total number of carbon atoms in the R2 group is no more than 5;(ie)
wherein one of R35a and R35b is H and the other is selected from: phenyl, which phenyl is optionally substituted by a group selected from halo, methyl, methoxy; pyridyl; and thiophenyl; and(if)
where R34 is selected from: H; C1-3 saturated alkyl; C2-3 alkenyl; C2-3 alkynyl; cyclopropyl; phenyl, which phenyl is optionally substituted by a group selected from halo, methyl, methoxy; pyridyl; and thiophenyl;(ig) halo;
when there is a single bond present between C2 and C3,
R2 is
where R36a and R36b are independently selected from H, F, C1-4 saturated alkyl, C2-3 alkenyl, which alkyl and alkenyl groups are optionally substituted by a group selected from C1-4 alkyl amido and C1-4 alkyl ester; or, when one of R16a and R16b is H, the other is selected from nitrile and a C1-4 alkyl ester;R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, SnMe3 and halo;
either
(a) R10 is H, and R11 is OH or ORA, where RA is C1-4 alkyl; or
(b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or
(c) R10 is H and R11 is OSOZM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation; or
(d) R11 is OH or ORA, where RA is C1-4 alkyl and R10 is selected from:
where Rz is selected from:(z-i)

(z-ii) OC(?O)CH3;
(z-iii) NO2;
(z-iv) OMe;
(z-v) glucoronide;
(z-vi) —C(?O)—X1—NHC(?O)X2—NH—RZC, where —C(?O)—X1—NH— and —C(?O)—X2—NH— represent natural amino acid residues and Rzc is selected from Me, OMe, OCH2CH2OMe;
Y is selected from formulae A1 and A2:

Z1 is a C1-3 alkylene group;
Z2 is a C1-3 alkylene group;
Q is:
where QX is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue;L is a linker connected to a cell binding agent;
CBA is the cell binding agent;
n is an integer between 0 and 48;
R and R? are each independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups, and optionally in relation to the group NRR?, R and R? together with the nitrogen atom to which they are attached form an optionally substituted 4-, 5-, 6- or 7-membered heterocyclic ring;
R8 is either:
(a) independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, SnMe3 and halo; or
(b) of formula A*:
wherein:D? represents either group D?1 or D2:

wherein the dotted line indicates the optional presence of a double bond between C2? and C3?;
R17 is independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, SnMe3 and halo;
R? is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms, e.g. O, S, N(H), NMe and/or aromatic rings, e.g. benzene or pyridine, which rings are optionally substituted; and
X and X? are independently selected from O, S and N(H); and
R22, R16, R19, R20 and R21 are as defined for R2, R6, R9, R10 and R11 respectively.

US Pat. No. 10,188,743

CYTISINE-LINKED ISOFLAVONOID ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER

University of Kentucky Re...

1. A method of treating prostate or colorectal cancer, the method comprising administering to a patient in need of prostate or colorectal cancer treatment an effective amount of a cytisine-linked isoflavonoid compound represented by formula (I):
or pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof,
wherein Ar is an aryl or heteroaryl; n is an integer from 1 to 5; each X is independently a halide, or alkoxy, or more than one X on Ar together form a cyclic ether structure; and wherein the compound is substituted on the C-2 position with H, alkyl, cycloalkyl or alkoxy, substituted on the C-5, C-6, C-7, and C-8 positions independently with H, hydroxy (OH), alkyl, cycloalkyl, alkoxy, L is a substituted or unsubstituted di-radical linker group that links the cytisinyl group to either the C-5, C-6, C-7 or C-8 position.

US Pat. No. 10,188,690

USE OF KAEMPFERIA PARVIFLORA WALL. EX. BAKER EXTRACTS OR FLAVONE COMPOUND FOR PREVENTING OR TREATING MUSCLE DISEASES, OR IMPROVING MUSCLE FUNCTION

AAT COSTECH CO., LTD., S...

1. A method of treating a human suffering from muscle atrophy comprising administering to said human suffering from muscle atrophy a therapeutically effective amount of a compound represented by Formula 4 or salt thereof to the human suffering from muscle atrophy,wherein Formula 4 is as follows:

wherein each of R1, R2, and R3 is independently selected from the group consisting of hydrogen and methoxy, and
wherein the human has a muscle disease selected from the group consisting of atony, muscular dystrophy, myasthenia, and sarcopenia.

US Pat. No. 10,188,646

BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS

SATIOGEN PHARMACEUTICALS,...

1. A method of treating or preventing obesity by increasing the concentration of bile acid in the distal gastrointestinal tract of a non-diabetic individual, comprising orally administering for local delivery to the distal ileum, the colon, or the rectum of the individual, a therapeutically effective amount of an Apical Sodium-dependent Bile Transporter Inhibitor (ASBTI), and wherein the ASBTI is formulated to be less than 10% systemically absorbed, wherein said ASBTI compound is selected fromand potassium((2R,3R,4S,5R,6R)-4-benzyloxy-6-{3-[3-((3S,4R,5R)-3-butyl-7-dimethylamino-3-ethyl-4-hydroxy-1,1-dioxo-2,3,4,5-tetrahydro-1H-benzo[b]thiepin-5-yl)-phenyl]-ureido}-3,5-dihydroxy-tetrahydropyran-2-ylmethyl)sulphate ethanolate hydrate, or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,188,642

PHARMACOLOGICALLY ACTIVE COMPOUNDS

Cancer Research Technolog...

1. A compound having the structural formula II shown below:
wherein:
X is CH or N;
Y is N or C—H;
R2 is (1-6C)alkyl, (1-8C)heteroalkyl, aryl, aryl(1-2C)alkyl, a 5 or 6 membered heteroaryl, a 5 or 6 membered heteroaryl(1-2C)alkyl, a 3 to 6 membered heterocyclyl, a 3 to 6 membered heterocyclyl(1-2C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl(1-2C)alkyl, C(O)R13, C(O)OR13, OC(O)R13, C(O)N(R14)R13, S(O)xR13 (where x is 0, 1 or 2), or SO2N(R14)R13;
and wherein R2 is optionally substituted by one or more substituent groups selected from fluoro, chloro, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, (1-4C)alkyl, (1-4C)alkoxy, S(O)xCH3 (where x is 0, 1 or 2), methylamino or dimethylamino, aryl, aryl(1-2C)alkyl, heteroaryl, heteroaryl(1-2C)alkyl, heterocyclyl, heterocyclyl(1-2C)alkyl, (3-8C)cycloalkyl, and (3-8C)cycloalkyl(1-2C)alkyl,
and wherein any (1-4C)alkyl, (1-4C)alkoxy, aryl, heteroaryl, heterocyclyl, or (3-8C)cycloalkyl moiety present within a substituent group on R2 is optionally further substituted by fluoro, chloro, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, (1-4C)alkyl, NRcRd, ORc, C(O)Rc, C(O)ORc, OC(O)Rc, N(Rd)ORc, C(O)N(Rd)Rc, N(Rd)C(O)Rc, S(O)yRc (where y is 0, 1 or 2), SO2N(Rd)Rc, or N(Rd)SO2Rc, wherein Rc and Rd are each independently H or (1-4C)alkyl;
R3 is hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl, halo, CF3, CN or (1-4C)alkoxy;
R4 is hydrogen, fluoro, chloro or CF3;
Ar has the formula:

wherein:
(i) all of A1, A2 and A3 are CH; or
(ii) A3 is CH and A1 or A2 are N or CH;
R5 is cyano, (1-3C)alkyl, (1-3C)fluoroalkyl, (1-3C)alkoxy, (1-3C)fluoroalkoxy, halo, (1-3C)alkanoyl, C(O)NR15R16 or S(O)2NR15R16, and wherein R15 and R16 are each independently H or (1-3C)alkyl, and wherein any alkyl or alkoxy moities present within a R5 substituent group are optionally further substituted by hydroxy or methoxy;
R6 is halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, ureido, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl,
or R6 is a group of the formula:
-L1-L2-R17
wherein
L1 is absent or a linker group of the formula —[CR18R19]n— in which n is an integer selected from 1, 2, 3 and 4, and R18 and R19 are each independently hydrogen or (1-2C)alkyl;
L2 is absent or is O, S, SO, SO2, N(R20), C(O), C(O)O, OC(O), CH(OR20), C(O)N(R20), N(R20)C(O), N(R20)C(O)N(R21), S(O)2N(R20), or N(R21)SO2, wherein R20 and R21 are each independently selected from hydrogen or (1-2C)alkyl; and
R17 is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl, or heterocyclyl-(1-4C)alkyl,
 and wherein R17 is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, nitro, hydroxy, NR22R23, (1-4C)alkoxy, (1-4C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-3C)alkyl, (1-5C)alkanoyl, (1-5C)alkylsulphonyl, heterocyclyl, heterocyclyl-(1-2C)alkyl, heteroaryl, heteroaryl-(1-2C)alkyl, CONR22R23, and SO2NR22R23; wherein R22 and R23 are each independently selected from hydrogen, (1-4C)alkyl or (3-6C)cycloalkyl or (3-6C)cycloalkyl(1-2C)alkyl; or R22 and R23 can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-6 membered heterocyclic ring ring;
 and wherein when said substituent group comprises an alkyl, cycloalkyl, heterocyclyl or heteroaryl moiety then said moiety is optionally further substituted by hydroxy, fluoro, chloro, cyano, CF3, OCF3, (1-2C)alkyl, (1-2C)alkoxy, SO2(1-2C)alkyl or NReRf (where Re and Rf are each independently hydrogen, (1-3C)alkyl, (3-6C)cycloalkyl, or (3-6C)cycloalkyl(1-2C)alkyl);
or R17 is a group having the formula:
-L3-L4-R24
wherein
L3 is absent or a linker group of the formula —[CR25R26]n— in which n is an integer selected from 1, 2, 3 or 4, and R25 and R26 are each independently hydrogen or (1-2C)alkyl;
L4 is absent or is O, S, SO, SO2, N(R27), C(O), C(O)O, OC(O), CH(OR27), C(O)N(R27), N(R27)C(O), N(R27)C(O)N(R28), S(O)2N(R27), or N(R28)SO2, wherein R27 and R28 are each independently hydrogen or (1-2C)alkyl; and
R24 is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl, or heterocyclyl-(1-4C)alkyl;
R13 is hydrogen, (1-6C)alkyl, (1-6C)alkoxy, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-2C)alkyl, aryl, aryl-(1-2C)alkyl, heteroaryl, or heteroaryl-(1-2C)alkyl, and wherein R13 is optionally further substituted by one or more substituents selected from hydroxy, fluoro, chloro, cyano, CF3, OCF3 (1-2C)alkyl and (1-2C)alkoxy;
R14 is hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, or (3-6C)cycloalkyl-(1-2C)alkyl, and wherein R14 is optionally further substituted by one or more substituents selected from hydroxy, fluoro, chloro, cyano, CF3, OCF3, (1-2C)alkyl and (1-2C)alkoxy;
subject to the proviso that:
X can only be N when Y is N;
when X and Y are both N, R3 is H or fluoro;
or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,188,618

TREATMENT OF CANCER WITH SPECIFIC RXR AGONISTS

IO Therapeutics, Inc., S...

1. A method of treating a hematologic malignancy, wherein the hematologic malignancy is a leukemia or a lymphoma, comprising administering to a patient in need of such treatment a retinoid X receptor (RXR) agonist at a dose below its Retinoic Acid Receptor (RAR) activating threshold and at or above its RXR effective dose, the RXR agonist has a chemical structure
where R is H, lower alkyl or 1 to 6 carbons, or a pharmaceutically acceptable salt of the compound, and the dose of the RXR agonist is from about 0.1 to about 20 mg/m2/day.

US Pat. No. 10,188,588

ACIDIC HYBRID MONOMERS AND DENTAL MATERIALS BASED THEREON

Ivoclar Vivadent AG, Sch...

1. Acidic monomer according to Formula I:
in which
A=a linear or branched aliphatic C1-C18-hydrocarbon group, which can be interrupted by one or more —O—, —S—, —CO—O—, —O—CO—NH—, —HN—CO—NH— or —CO—NR1—,
R1=H or a C1-C6 alkyl group,
X=is absent or is a linear or branched aliphatic C1-C10 hydrocarbon group, which can be interrupted by one or more —O—, —S—, —CO—O—, —O—CO—NH—, —HN—CO—NH— or —CO—NR2—,
R2=H or a C1-C6 alkyl group,
PG=a radically polymerizable group selected from vinyl, allyl, CH2?CR3—CO—Y— or R4O—CO—C(?CH2)—CH2—Y—,
Y=O or NR5 or is absent,
R3=H or CH3
R4=H or a C1-C7 alkyl group,
R5=H or a C1-C7 alkyl group,
n=1, 2, 3 or 4,
m=1 or 2,
p=1, 2 or 3, and
q=1, 2 or 3.

US Pat. No. 10,188,571

ADAPTER FOR CONNECTING AT LEAST ONE ACCESSORY DEVICE TO AN OPERATING TABLE

1. An operating table adapter, comprising: a table mount configured to removably attach the adapter to an operating table; and an accessory mount configured to attach a surgery extension device to the adapter; wherein the adapter includes a free-standing, X-ray transparent member; wherein the X-ray transparent member includes a first part comprising a lower surface configured to directly contact an upper support surface of the operating table, and a second part configured to extend beyond the upper support surface in a longitudinal direction of the upper support surface when the adapter is mounted to the operating table via the table mount; wherein the second part of the X-ray transparent member comprises a support surface extension configured to support a patient when the adapter is attached to the operating table; and the table mount comprising: a guide rod, the guide rod being elongated and extending downward with respect to the X-ray transparent member when the adapter is attached to the operating table; and an abutment element, the abutment element being movable vertically along the guide rod towards and away from the X-ray transparent member, and being lockable along the guide rod; wherein when the operating table adapter is positioned on said operating table, the abutment element is movable along the guide rod and lockable against a bottom surface of the operating table, to thereby grasp the operating table between the first part of the X-ray transparent member and the abutment element.

US Pat. No. 10,188,562

DISPOSABLE DIAPER AND A METHOD OF MANUFACTURING A DISPOSABLE DIAPER

UNICHARM CORPORATION, Eh...

1. A disposable diaper, comprising:a front waistline region, a rear waistline region, a crotch region positioned between the front waistline region and the rear waistline region;
a product longitudinal direction from the front waistline region towards the rear waistline region, and a product widthwise direction perpendicular to the product longitudinal direction;
a skin-surface side sheet adapted to face toward a body of a wearer when the diaper is worn;
a non-skin surface side sheet adapted to face away from the body of the wearer when the diaper is worn;
an absorber arranged between the skin-surface side sheet and the non-skin surface side sheet, running across the crotch region in the product longitudinal direction, and extending from the crotch region to at least either one of the front waistline region and rear waistline region;
a waistline retaining unit disposed in the front and rear waistline regions and adapted to hold the disposable diaper onto the body of the wearer;
leg stretching units arranged along leg hole openings provided on an outer side of the absorber in the product widthwise direction, said leg stretching unit being configured to expand and contract along the product longitudinal direction; and
diaper ends defining an outer circumference of the disposable diaper,
wherein
the leg stretching units are arranged between the skin-surface side sheet and the non-skin surface side sheet,
in a plan view of the disposable diaper, the leg stretching units are arranged on an inner side of the diaper ends in the product longitudinal direction or on the inner side of the diaper ends in the product widthwise direction,
the leg stretching units have ends opposing each other in the product longitudinal direction,
a part of the waistline retaining unit is arranged in at least one of
a first region on an outer side in the product longitudinal direction from the ends of the leg stretching units, or
a second region on an outer side in the product widthwise direction from the ends of the leg stretching units,
a joint region where the skin-surface side sheet and the non-skin surface side sheet are joined is provided along the diaper ends in at least one of the first region or the second region,
a first adhesive is applied at an interval, on the skin-surface side sheet of the first region and the second region, based on a first application pattern, and
a second adhesive is applied at an interval, on the non-skin surface side sheet of the first region and the second region, based on a second application pattern different from the first application pattern.

US Pat. No. 10,188,555

SHEAR RESISTANT WOUND DRESSING FOR USE IN VACUUM WOUND THERAPY

1. A negative pressure wound therapy dressing comprising:a backing layer comprising a flexible polymeric membrane, the backing layer including a lower wound facing side, an upper side opposite the lower wound facing side, and an aperture extending through the backing layer;
a porous layer disposed below the lower wound facing side of the backing layer;
an absorbent filler, wherein the absorbent filler is configured to be in fluid communication with the porous layer and configured to collect exudate removed from a wound; and
a vacuum port configured to be fluidically connected, via a tube, to a negative pressure source, wherein the vacuum port comprises:
a flange having an underside and a top side, wherein the underside of the flange has an opening positioned over the aperture in the backing layer and the underside of the flange is positioned on the upper side of the backing layer; and
a connector extending above the flange, the connector configured to be connected to the tube;
a screen positioned across the opening on the underside of the flange configured to prevent migration of particles into the vacuum port, wherein the screen comprises openings having a size configured to prevent migration of particles into the vacuum port, the size of the openings being large enough for liquid wound exudate to pass through the screen.

US Pat. No. 10,188,513

PROSTHETIC TISSUE VALVES

CORMATRIX CARDIOVASCULAR,...

1. A prosthetic valve for modulating fluid flow through a cardiovascular structure during cardiac cycles of a heart, said fluid flow exhibiting a plurality of positive and negative flow pressures during said cardiac cycles, said prosthetic valve comprising:a valve structure comprising a remodelable conical shaped sheet member, said sheet member comprising an extracellular matrix (ECM) composition, said ECM composition comprising acellular ECM from a mammalian tissue source,
said sheet member further comprising an open proximal annulus engagement end configured to engage said cardiovascular structure and receive said fluid flow therein and a closed distal end,
said sheet member further comprising a plurality of linear interstices disposed between said sheet member open proximal annulus engagement end and said closed distal end, wherein said plurality of linear interstices do not extend to said closed distal end,
said sheet member being configured to transition from an expanded position when said proximal annulus engagement end of said sheet member is engaged to said cardiovascular structure and receives said fluid flow therein, and said fluid flow exhibits a first positive flow pressure of said plurality of positive flow pressures, to a collapsed position when said fluid flow exhibits a first negative flow pressure of said plurality of negative flow pressures,
said plurality of linear interstices being configured to transition from an open position, when said sheet member is in said expanded position, to a closed position, when said sheet member is in said collapsed position,
said closed distal end of said sheet member being configured to block said fluid flow therethrough when said plurality of linear interstices are in said open and closed positions, wherein when said plurality of linear interstices are in said open position, said plurality of linear interstices allow said fluid flow to be transmitted through said plurality of linear interstices and sheet member, and wherein when said plurality of linear interstices are in said closed position, said plurality of linear interstices and said closed distal end of said sheet member jointly block said fluid flow through said sheet member,
said sheet member being further configured to remodel, and induce host cell and tissue proliferation, remodeling of damaged cardiovascular tissue and regeneration of new cardiovascular tissue and tissue structures with site-specific structural and functional properties, when said proximal annulus engagement end of said sheet member is engaged to said cardiovascular structure, wherein said proximal annulus engagement end of said sheet member is disposed proximate damaged tissue of said cardiovascular structure; and
a biodegradable multi-link support stent structure disposed in said sheet member.

US Pat. No. 10,188,510

PROSTHETIC TISSUE VALVES

CorMatrix Cardiovascular,...

1. A prosthetic valve for modulating fluid flow through a cardiovascular structure during cardiac cycles of a heart, said fluid flow exhibiting a plurality of positive and negative flow pressures during said cardiac cycles, said prosthetic valve comprising:a remodelable biological tissue structure comprising a continuous tubular member,
said tubular member comprising an adaptive tissue regeneration system configured to engage said cardiovascular structure and induce modulated healing of damaged cardiovascular tissue of said cardiovascular structure concomitantly with stress-induced hypertrophy of said tubular member when said tubular member is subjected to cardiac cycle induced physical stimuli,
said modulated healing of said damaged cardiovascular tissue comprising inflammation modulation of said damaged cardiovascular tissue and induced neovascularization, remodeling of said damaged cardiovascular tissue and regeneration of new cardiovascular tissue and tissue structures with site-specific structural and functional properties,
said stress-induced hypertrophy of said tubular member comprising adaptive remodeling of said tubular member, wherein said tubular member remodels and forms functioning valve structures that are similar to native valve structures,
said adaptive tissue regeneration system comprising a tubular member material component and a tubular member physical structure component,
said tubular member material component comprising an extracellular matrix (ECM) composition, said ECM composition comprising acellular ECM from a mammalian tissue source,
said tubular member physical structure component comprising a sheet member comprising a proximal valve annulus engagement end and a distal end, said proximal valve annulus engagement end of said sheet member being configured to engage a valve annulus region of said cardiovascular structure,
said proximal valve annulus engagement end comprising a circumferential ribbon connection region and a plurality of equally spaced ribbons projecting from said circumferential ribbon connection region toward said sheet member distal end,
each of said plurality of ribbons comprising proximal and distal ends, a first edge region extending from said proximal end of each of said plurality of ribbons to said distal end of each of said plurality of ribbons and a second edge region extending from said proximal end of each of said plurality of ribbons to said distal end of each of said plurality of ribbons,
said proximal end of each of said plurality of ribbons being connected to said circumferential ribbon connection region,
said plurality of ribbons being positioned circumferentially about said circumferential ribbon connection region, wherein said first edge regions of said plurality of ribbons are positioned proximate said second edge regions of said plurality of ribbons, wherein a plurality of fluid flow modulating regions is formed between adjacent ribbons of said plurality of ribbons,
said distal ends of said plurality of ribbons being engaged to each other in a joined relationship, wherein fluid flow through said sheet member at said joined distal ends of said plurality of ribbons is restricted while said fluid flow is allowed to be transmitted through said fluid flow modulating regions when in an open position,
said sheet member being configured to transition from an expanded position when said proximal valve annulus engagement end of said sheet member is engaged to said valve annulus region of said cardiovascular structure and receives said fluid flow therein, and said fluid flow exhibits a first positive flow pressure of said plurality of positive flow pressures, to a collapsed position when said fluid flow exhibits a first negative flow pressure of said plurality of negative flow pressures,
said plurality of fluid flow modulating regions being configured to transition from said open position when said sheet member is in said expanded position, wherein said plurality of fluid flow modulating regions allow said fluid flow to be transmitted through said sheet member, to a closed position when said sheet member is in said collapsed position, wherein said plurality of fluid flow modulating regions restrict said fluid flow through said sheet member.

US Pat. No. 10,188,509

PROSTHETIC TISSUE VALVES

CORMATRIX CARDIOVASCULAR,...

1. A prosthetic valve for modulating fluid flow through a cardiovascular structure during cardiac cycles of a heart, said fluid flow exhibiting a plurality of positive and negative flow pressures during said cardiac cycles, said prosthetic valve comprising:a remodelable biological tissue structure comprising a conical shaped sheet member, said sheet member comprising an extracellular matrix (ECM) composition, said ECM composition comprising acellular ECM from a mammalian tissue source,
said sheet member further comprising an open proximal annulus engagement end configured to engage said cardiovascular structure and receive said fluid flow therein and a closed distal end,
said sheet member further comprising a plurality of linear interstices disposed between said sheet member open proximal annulus engagement end and said closed distal end, wherein said plurality of linear interstices do not extend to said closed distal end,
said sheet member being configured to transition from an expanded position when said proximal annulus engagement end of said sheet member is engaged to said cardiovascular structure and receives said fluid flow therein, and said fluid flow exhibits a first positive flow pressure of said plurality of positive flow pressures, to a collapsed position when said fluid flow exhibits a first negative flow pressure of said plurality of negative flow pressures,
said plurality of linear interstices being configured to transition from an open position, when said sheet member is in said expanded position, to a closed position, when said sheet member is in said collapsed position,
said closed distal end of said sheet member being configured to block said fluid flow therethrough when said plurality of linear interstices are in said open and closed positions, wherein when said plurality of linear interstices are in said open position, said plurality of linear interstices allow said fluid flow to be transmitted through said plurality of linear interstices and said sheet member, and wherein when said plurality of linear interstices are in said closed position, said plurality of linear interstices and said distal end of said sheet member jointly block said fluid flow through said sheet member,
said sheet member being further configured to remodel, and induce host cell and tissue proliferation, remodeling of damaged cardiovascular tissue and regeneration of new cardiovascular tissue and tissue structures with site-specific structural and functional properties, when said proximal annulus engagement end of said sheet member is engaged to said cardiovascular structure, wherein said proximal annulus engagement end of said sheet member is disposed proximate damaged tissue of said cardiovascular structure.

US Pat. No. 10,188,500

STENT GRAFT WITH EXTERNAL SCAFFOLDING AND METHOD

Medtronic Vascular, Inc.,...

1. A scaffolded stent-graft comprising:a hydrophobic graft material comprising an inner surface and an outer surface, the inner surface defining a lumen within the graft material, the graft material being hostile to tissue ingrowth therein; and
a scaffold comprising a metallic material mesh comprising openings therein coupled to the graft material at the outer surface, the scaffold configured to promote tissue ingrowth therein, the scaffold comprising a metal to artery ratio optimized to create stasis of blood within the scaffold resulting in thrombus formation, wherein the mesh is in the shape of a torus.

US Pat. No. 10,188,496

VENA CAVA FILTER FORMED FROM A SHEET

C. R. BARD, INC., Murray...

1. A blood filter for use in a patient's blood vessel having a vessel wall surrounding a vessel lumen, comprising:a) a longitudinally extending filter body including a proximal section extending a first fixed distance from a proximal terminal end of the longitudinal filter body to a first intermediate endpoint, said proximal section having a first cross-sectional area;
b) a distal section having a distal terminal end and a second cross-sectional area;
c) a joining section positioned between the proximal and distal sections and having a third cross-sectional area less than both the first and second cross-sectional areas;
d) said joining section spaced away from each of said terminal ends and extending a fixed second distance;
e) a first hub on said joining section that is slidable a fixed distance along a length of said joining section and in between said proximal and distal sections while in use in the blood vessel;
f) a plurality of appendages, each attached to said hub at an inner appendage end portion, each appendage having an outer appendage end portion providing unattached distal-most ends extending radially outward of said hub;
g) wherein said appendages are bendable in both a proximal and distal direction, thus enabling insertion of said filter body with hub and appendages using either a jugular access site or a femoral access site; and
h) wherein said filter body, said hub and said appendages are configured to occupy a vessel of a patient.

US Pat. No. 10,188,492

NAPKIN BAND WITH DENTAL FLOSS

1. A napkin band, the napkin band comprising:a generally rectangular portion;
a sealed pocket located generally along the length of the rectangular portion;
a length of dental floss located inside the sealed pocket; and
wherein the sealed pocket is formed from a portion of the generally rectangular portion folded back upon the rectangular portion, and where the sealed pocket is sealed along its length and ends by an adhesive.

US Pat. No. 10,188,457

SELECTABLE ECCENTRIC REMODELING AND/OR ABLATION

Vessix Vascular, Inc., L...

1. An apparatus comprising:a catheter configured for intravascular placement within a blood vessel of a human patient;
an expandable balloon at a distal portion of the catheter, wherein the expandable balloon is configured to vary between a delivery configuration and a deployed configuration sized to fit within the blood vessel;
a first pair of bipolar contacts attached to the expandable balloon; and
a second pair of bipolar contacts attached to the expandable balloon,
wherein the first pair of bipolar contacts and the second pair of bipolar contacts are spaced apart lengthwise and angularly offset from one another when the expandable balloon is in the deployed configuration,
wherein each of the first pair of bipolar contacts and the second pair of bipolar contacts is configured to deliver thermal energy to less than a full circumference of the blood vessel of the patient.

US Pat. No. 10,188,447

ELECTROSURGICAL SYSTEM

GYRUS MEDICAL LIMITED, C...

1. An electrosurgical system comprising:an electrosurgical generator;
a source of ionisable gas;
a controller; and
an electrosurgical instrument, the electrosurgical generator including a source of RF energy, the system also including a first connector and the electrosurgical instrument including a second connector,
the first connector being configured to connect with the second connector,
the first connector comprising a first set of at least three connector components,
the second connector comprising a second set of at least three connector components,
each of the three connector components of the first set being configured to connect to and disconnect from a respective one of the at least three connector components of the second set,
a connection between the first connector component of the first set and the first connector component of the second set is configured to allow the electrosurgical generator to deliver an RF energy output from the source of RF energy to the electrosurgical instrument,
a connection between the second connector component of the first set and the second connector component of the second set is configured to allow the source of ionisable gas to deliver a supply of ionisable gas to the electrosurgical instrument,
a connection between the third connector component of the first set and the third connector component of the second set is configured to allow the controller to identify the electrosurgical instrument, and
the third connector component of the first set being configured to connect to the third connector component of the second set only after the first connector component of the first set is connected to the first connector component of the second set and the second connector component of the first set is connected to the second connector component of the second set, wherein the controller is adapted to inhibit the supply of RF energy until after the controller has successfully identified the electrosurgical instrument.

US Pat. No. 10,188,435

INSTRUMENTS AND METHODS FOR TENSIONING A SPINAL TETHER

DEPUY SYNTHES PRODUCTS, I...

1. A tether tensioning device, comprising:an elongate shaft adapted to be positioned adjacent to a bone anchor implanted in bone;
a tensioning arm pivotally connected to a plate such that the pivot point of the tensioning arm is offset from the elongate shaft, the tensioning arm being adapted to couple to a tether seated across the bone anchor and to pivot past a longitudinal axis of the elongate shaft to apply a tensioning force to the tether; and
an overload mechanism disposed within the elongate shaft and coupled to the plate, wherein the overload mechanism is configured to prevent the applied tensioning force from exceeding a threshold force.

US Pat. No. 10,188,432

SNAP-ON MULTI-PLANAR AND MONO-PLANAR RECEIVER ASSEMBLIES HAVING INTEGRAL AND MULTI-PART MULTIPURPOSE POSITIONERS FOR PIVOTING AND NON-PIVOTING RETAINERS

16. A pivotal bone anchor assembly for securing an elongate rod to a bone, the bone anchor assembly comprising:a bone anchor having a capture portion and an integral anchor portion extending distally from the capture portion for fixation to the bone;
a receiver comprising a base defining a cavity having a bottom opening in communication with a bottom surface of the base and a pair of integral arms extending upwardly from the base to define a U-shaped channel configured to receive the elongate rod, the U-shaped channel being in communication with the cavity and the cavity having an internal circumferential recess above the bottom opening;
a retainer expandable within the circumferential recess and having an inner surface operable to capture the bone anchor capture portion; and
a positioner disposed within the receiver cavity and engaged with the retainer to stabilize and centralize the retainer within the receiver cavity above a lower portion of the cavity adjacent the bottom opening and entirely spaced from internal surfaces of the receiver cavity, prior to receiving the capture portion of the bone anchor,
wherein, upon insertion of the bone anchor capture portion into the receiver cavity through the bottom opening, the retainer is released from the positioner and moved to the lower portion of the cavity, thereby allowing the retainer inner surface to capture and hold the bone anchor capture portion within the receiver cavity.

US Pat. No. 10,188,427

SPINAL CONSTRUCT AND METHOD

Warsaw Orthopeic, Inc., ...

1. A spinal construct comprising:a connector extending along a longitudinal axis between a first end and a second end, the first end comprising a passageway, a shaft of the second end being positioned within the passageway such that the second end can translate relative to the first end along the longitudinal axis, the ends each comprising a threaded hole extending through a top surface of the connector,
wherein the first end comprises a first expandable member including an inner surface defining a cavity configured to receive a head of a first bone fastener and the second end comprises a second expandable member including an inner surface defining a cavity configured to receive a head of a second bone fastener, the cavities each including an opening extending through a bottom surface of the connector, the expandable members each comprising a retaining member positioned in a respective one of the cavities, an inner locking ring positioned in a respective one of the cavities and a notch that extends into a respective one of the inner surfaces, the openings each having a maximum diameter greater than a maximum diameter of each of the retaining members, the retaining members being configured to expand radially and then collapse back to their original form when one of the heads contacts one of the retaining members, the inner locking rings being configured to be pushed into one of the notches when one of the heads is received by one of the retaining members.

US Pat. No. 10,188,422

BIOPSY NEEDLE DESIGN

3DBiopsy, Inc., Aurora, ...

1. An apparatus, comprising:a cannula, comprising:
a tubular body extending between a first end and a second end, the tubular body having a first side and an opposite second side; and
a leading edge formed at the first end, the leading edge extending along a first plane, the first plane extending between the first side and second side, the first plane forming a leading edge angle between the intersection of the first side and the first plane, wherein the leading edge angle is between 12 degrees and 20 degrees;
a mandrel, comprising:
a body extending between a first end and a second end;
a trocar point formed by the first end;
a notch formed by the body, the notch forming a bed extending between the first end and the second end;
a first sample region formed by the bed, the first sample region, comprising:
a first plurality of ridges, wherein each of the first plurality of ridges comprises:
a flank extending from the bed toward the second end, the flank terminating at a crest;
a second sample region formed by the bed, the second sample region comprising:
a second plurality of ridges, wherein each of the second plurality of ridges comprises:
a flank extending from the bed toward the second end, the flank terminating in a crest; and
a concave slope descending from the crest; and
a deck disposed between the first plurality of ridges and the second plurality of ridges;
a cannula force source imparting movement to the cannula, wherein the cannula force source imparts a loaded force between 7 lbs. and 11 lbs.

US Pat. No. 10,188,409

ASPIRATION THROMBECTOMY CATHETER SYSTEM, AND ASSOCIATED METHODS

Smalling Medical Ventures...

1. A method for aspirating a thrombus from a vessel, the thrombus having at least a first portion and a second portion, wherein the first portion is within an innermost layer of the thrombus and the second portion is within a medial or an intimal layer of the thrombus, the method comprising the steps of:inserting an aspiration catheter into the vessel, the aspiration catheter having a first lumen and a second lumen disposed therein, a tapering distal end and a plurality of aspiration port sets arranged along the tapering distal end, each of the plurality of aspiration port sets having a plurality of ports for aspirating thrombus from the vessel, and wherein at least one of the plurality of aspiration port sets is in fluidic communication with the first lumen and at least another one of the plurality of aspiration port sets are in fluidic communication with the second lumen;
advancing the aspiration catheter within the vessel until an aspiration port set closest to a tip of the tapering distal end of the aspiration catheter is proximate the first portion of the thrombus;
applying aspiration forces through at least the aspiration port set closest to the tip of the tapering distal end of the aspiration catheter to suction at least the first portion of the thrombus into the first lumen;
advancing the aspiration catheter through the thrombus until the aspiration port set closest to the tip of the tapering distal end of the aspiration catheter is proximate to the second portion of the thrombus; and
applying aspiration forces through an aspiration port set disposed closest to a proximal end of the tapering distal end of the aspiration catheter to suction at least the second portion of the thrombus into at least one of the first and second lumens;
wherein each of the plurality of ports comprising the aspiration port set closest to the tip of the tapering distal end of the aspiration catheter is smaller in size than each of the plurality of ports comprising the aspiration port set disposed closest to the proximal end of the tapering distal end of the aspiration catheter.

US Pat. No. 10,188,408

GLENOID CAVITY BONE PREPARATION SET FOR SETTING A SHOULDER PROSTHESIS, AND METHOD FOR IMPLANTING A SHOULDER PROSTHESIS

FOURNITURES HOSPITALIERES...

1. A glenoid cavity bone preparation set for setting a shoulder prosthesis, comprising:a drill guide comprising:
a bearing surface intended to bear against a glenoid cavity of a scapula which has been prepared beforehand,
a passage orifice opening into the bearing surface of the drill guide and intended for the passage of a guide pin implanted in the glenoid cavity, and
a first guide orifice and a second guide orifice each opening into the bearing surface of the drill guide and each intended to guide a drill bit capable of realizing a bone bore in the glenoid cavity, the first and second guide orifices being inclined with respect to an extension axis of the passage orifice of the drill guide and converging in the direction of the bearing surface of the drill guide,
a compactor comprising a compaction portion having a generally trapezoidal shape and intended to be impacted against the glenoid cavity so as to form a bone housing in the glenoid cavity, the compactor further including a passage hole extending at least partially in the compaction portion and intended for the passage of the guide pin implanted in the glenoid cavity.

US Pat. No. 10,188,407

DRILL GUIDE FOR ACETABULAR CUP FASTENERS

HIP INNOVATION TECHNOLOGY...

1. A surgical tool system adapted for drilling holes in an acetabulum to accommodate screws used to fasten an acetabular cup to the acetabulum, the acetabular cup comprising a concave portion having a stem extending from the bottom thereof, cup slots disposed in the concave portion in close proximity to a circumferential edge of the acetabular cup and one or more through holes to accommodate screws for fastening the acetabular cup to the acetabulum, the surgical tool system comprising:a drill guide sized to fit within the concave portion and having spring-loaded pins arranged to engage the cup slots when the drill guide is optimally positioned within the acetabular cup, the drill guide further comprising one or more through holes sized and spaced to line up approximately concentrically with the through holes of the acetabular cup and a guide indent for each hole, each guide indent being positioned on a beam member which traverses the drill guide at a circumferential edge thereof;
a handle comprising a shaft with a drill bit guide disposed at the distal end thereof, the drill bit guide having a drill bit guide distal end and a side portion, the drill bit guide being sized to engage a hole and the side portion being positioned to engage the guide indent for its respective hole; and
a drill bit having a cutting portion and a shaft sized to pass through the drill bit guide.

US Pat. No. 10,188,372

SURGICAL INSTRUMENT GUIDE DEVICE

Cambridge Endoscopic Devi...

1. A surgical instrument assembly comprising:a manually operated instrument that includes;
an elongated instrument shaft having proximal and distal ends,
a control handle,
a proximal motion member that connects the control handle to the proximal end of the elongated instrument shaft,
an end effector,
a distal motion member that connects the distal end of the elongated instrument shaft to the end effector,
a guide member for receiving the instrument shaft, having proximal and distal ends and including;
a guide shaft,
a distal motion means at the distal end of said guide shaft,
a proximal motion means at the proximal end of said guide shaft; and
actuation means extending between said distal and proximal motion means so that any deflection of said proximal motion means causes a corresponding deflection of said distal motion means for control of said end effector, said end effector extending beyond the distal motion means at an operative site.

US Pat. No. 10,188,356

RADIATION SYSTEMS

VARIAN MEDICAL SYSTEMS, I...

1. A radiation system, comprising:a treatment device having a structure, and a first radiation source coupled to the structure, wherein the first radiation source is configured to rotate about an axis and to deliver a treatment radiation beam;
a rail system associated with the structure; and
a MRI device moveably coupled to the rail system;
wherein the rail system is configured to guide the MRI device from a first position to a second position, the second position being closer to the treatment device than the first position;
wherein the treatment device is at an operative position for delivering the treatment radiation beam; and
wherein when the treatment device is at the operative position, and when the MRI device is at the second position, the MRI device is next to the treatment device so that a spacing between the MRI device and treatment device is less than a thickness of the MRI device or the treatment device, and the MRI device is behind the treatment device along the axis.

US Pat. No. 10,188,355

BACKGROUND-SUPPRESSED, REDUCED FIELD-OF-VIEW RADIAL MAGNETIC RESONANCE IMAGING

Siemens Healthcare GmbH, ...

1. A computer-implemented magnetic resonance imaging (MRI) method for acquiring images of a patient, the method comprising:receiving, by an input processor, user input comprising an indication of a field of view (FOV) that encompasses only an anatomy of interest of the patient, the anatomy of interest smaller than a full dimension of the patient;
shimming, by a processor configured to communicate with the input processor, on the anatomy of interest within the FOV;
applying, by the processor, a radial quiescent-interval slice-selective (QISS) pulse sequence including a magnetization preparation pulse to the shimmed FOV to acquire images of the anatomy of interest; and
generating, at a display processor configured to communicate with the processor, data representing the acquired images of the anatomy of interest.

US Pat. No. 10,188,354

PATIENT STATUS NOTIFICATION DEVICE, NOTIFICATION METHOD IN PATIENT STATUS NOTIFICATION DEVICE AND PROGRAM

PARAMOUNT BED CO., LTD., ...

1. A system for monitoring patient status, comprising:at least one sensor that automatically and continuously acquires biological data from a patient;
a plurality of destination terminal devices; and
a controller configured to:
continuously receive biological data from the at least one sensor;
compare currently received biological data with one or more threshold values;
trigger a first alarm message at a first destination terminal device if the currently received biological data is determined to be outside of a first range based on the comparison with the one or more threshold values;
trigger a second alarm message at a second destination terminal device if the currently received biological data is determined to be outside of a second range based on the comparison with the one or more threshold values;
wherein the second range includes the first range, and the first destination terminal device is different from the second destination terminal device,
wherein the one or more threshold values compared with the received biological data are selected based on an associated patient identifier, a type of the currently received biological data and a notice setting in an alarm notice level table.

US Pat. No. 10,188,353

SYSTEMS AND METHODS FOR MONITORING AUTONOMIC HEALTH

Cardiac Pacemakers, Inc.,...

1. A method, comprising:delivering an autonomic neural stimulation (ANS) dose over a plurality of burst periods, including delivering a burst stimulation pulses within a portion of each burst period to evoke physiological responses and not delivering stimulation pulses within another portion of each burst period;
recording physiological parameter values, including:
recording first population data, the first population data including evoked response (ER) values corresponding to the evoked physiological responses to the burst of stimulation pulses for the plurality of burst periods; and
recording second population data, the second population data including reference values that include no effect (NE) values corresponding to times without an evoked physiological response;
calculating evoked response metrics (ERMs) using the first and second population data, each of the ERMs being dependent on background autonomic activity;
analyzing the ERMs to provide ERM analysis; and
providing an indication of autonomic health using the ERM analysis.

US Pat. No. 10,188,341

METHOD AND DEVICE FOR DETECTING SPEECH PATTERNS AND ERRORS WHEN PRACTICING FLUENCY SHAPING TECHNIQUES

Novotalk, Ltd., Tel-Aviv...

1. A method for detecting errors when practicing fluency shaping exercises, comprising:receiving a set of initial energy levels;
setting each threshold of a set of thresholds to a respective predetermined initial value;
receiving a voice production of a user practicing a fluency shaping exercise;
analyzing the received voice production to compute a set of energy levels composing the voice production;
detecting at least one speech-related error based on the computed set of energy levels, the set of initial energy levels, and the set of a thresholds, wherein the detection of the at least one speech-related error is with respect to the fluency shaping exercise being practiced by the user; wherein the set of initial energy levels includes at least one of: a normal speech energy level, a silence energy level, and a calibration energy level,
upon detection of the at least one speech-related error, generating visual feedback indicating the at least one detected speech-related error with respect to the received voice production, and
performing an audio calibration process for a computing device of the user to set the normal speech energy level, the silence energy level, and the calibration energy level, wherein the voice production is captured on the computing device of the user,
wherein processing the received voice production further comprises: sampling the received voice production to create voice samples; buffering the voice samples to create voice chunks; converting the voice chunks from a time domain to a frequency domain; extracting spectrum features from each of the frequency domain voice chunks, wherein the spectrum features include at least dominant frequencies, wherein each dominant frequency corresponds to a voice chunk; computing, for each voice chunk, the energy level of the corresponding dominant frequency; and determining, for each voice chunk, an energy level of the voice chunk based on the energy level of the corresponding dominant frequency.

US Pat. No. 10,188,335

PLASMA OR SERUM PRODUCTION AND REMOVAL OF FLUIDS UNDER REDUCED PRESSURE

Seventh Sense Biosystems,...

21. A device for receiving blood from a subject and processing the blood to form plasma or serum, the device comprising:an inlet for introduction of a bodily fluid from the subject into the device;
a storage chamber for receiving plasma or serum;
a first membrane that is substantially impermeable to cells, wherein the first membrane separates the inlet from the storage chamber and is capable of separating blood passing through to produce a portion enriched in plasma or serum;
a vacuum chamber, separate from the storage chamber, having a pressure less than ambient pressure; and
a second membrane that is gas permeable but is substantially liquid impermeable, wherein the second membrane separates the storage chamber from the vacuum chamber.

US Pat. No. 10,188,332

METHOD AND SYSTEM FOR SENSING GLUCOSE CONCENTRATION

NATIONAL CHENG KUNG UNIVE...

1. A system for sensing glucose concentration, the system comprising:a light source configured to generate a light beam;
a polarization state generator configured to receive the light beam, wherein the polarization state generator comprises a modulator for changing a polarization of the light beam, and the light beam passing the modulator is emitted to a biological tissue;
a polarization state analyzer configured to receive the light beam reflected from the biological tissue; and
a controlling module configured to transmit an electrical signal to the modulator, wherein the electrical signal has n sampling points which correspond to n polarizations of the light beam respectively, the n polarizations are different from each other, and n is a positive integer greater than or equal to 4,
wherein for each of the n sampling points, the controlling module calculates a Stokes vector according to the light beam received by the polarization state analyzer,
wherein the controlling module calculates a Mueller matrix according to the Stokes vectors corresponding to the n sampling points, and calculates at least one parameter according to the Mueller matrix, wherein the at least one parameter comprises a depolarization index or an optical rotation angle,
wherein the controlling module calculates a glucose concentration corresponding to the biological tissue according to the at least one parameter.

US Pat. No. 10,188,331

NON-INVASIVE PHYSIOLOGICAL SENSOR COVER

MASIMO CORPORATION, Irvi...

1. A partially opaque sensor cover for use with a pulse oximeter sensor, the partially opaque sensor cover comprising:a partially opaque portion attachable to the sensor and configured to block optical readings by the sensor; and
a tab portion that protrudes from the sensor to facilitate removal of the partially opaque sensor cover,
wherein the sensor comprises:
a light source configured to emit light from one or more emitters of the sensor; and
a detector configured to receive at least a portion of the light emitted by the one or more emitters after the light has passed through a tissue site, and
wherein the partially opaque portion at least partially prevents the detector from receiving light during sensor activation.

US Pat. No. 10,188,328

NON-INVASIVE BIOLIPID CONCENTRATION METER, NON-INVASIVE BIOLIPID METABOLISM MEASURING DEVICE, NON-INVASIVE METHOD FOR MEASURING BIOLIPID CONCENTRATION, AND NON-INVASIVE METHOD FOR EXAMINING BIOLIPID METABOLISM

NATIONAL UNIVERSITY CORPO...

1. A non-invasive biolipid concentration measuring device configured to non-invasively measure a blood lipid concentration in a living body, the non-invasive biolipid concentration measuring device comprising:an irradiator configured to emit consecutive light through the living body, the light having a light intensity and wavelength being either 580 nm to 1400 nm or 1500 nm to 1860 nm, toward an irradiation position;
a light intensity detector configured to receive, detect and measure light emitted from the irradiator, the light intensity detector being disposed at a detection position separated by a given distance from the irradiation position, the light intensity detector detecting and measuring the light intensity of the light at the detection position;
a scattering coefficient calculator configured to calculate a light scattering coefficient based on the light intensity detected by the light intensity detector; and
a lipid concentration calculator configured to calculate the blood lipid concentration based on the light scattering coefficient calculated by the scattering coefficient calculator,
wherein, regardless of whether an absorption coefficient is known or unknown, the scattering coefficient calculator calculates a light scattering coefficient of the living body from a gradient of a line obtained by linearizing an attenuation rate of the light intensity with respect to the irradiation-detection distance between the irradiation position and the light intensity detector, and
the scattering coefficient calculator calculates scattering coefficient ?s? by applying light intensity R (?) detected by the light intensity detector and the irradiation-detection distance ? into Expression (1) and Expression (2)

where ?a represents the absorption coefficient, ?eff represents an effective attenuation coefficient, and S0 represents the light intensity of light emitted by the irradiator.

US Pat. No. 10,188,327

PORTABLE CLINICAL ANALYSIS SYSTEM FOR HEMATOCRIT MEASUREMENT

Abbott Point of Care Inc....

1. A method of performing a hematocrit analysis, the method comprising:inserting a test device comprising a hematocrit sensor into a port of an analyzer;
initiating, by the analyzer, a test cycle of the test device, the test cycle including performance of the hematocrit analysis, wherein the performance of the hematocrit analysis includes the test device generating an electric signal based on a hematocrit measurement of a biological sample;
determining spatial orientation and/or motion of the analyzer during the test cycle of the test device;
comparing the determined spatial orientation to a threshold operating spatial plane for the test device and/or comparing the determined motion to a threshold rate of motion for the test device;
when the determined spatial orientation exceeds the threshold operating spatial plane, and/or the determined motion exceeds the threshold rate of motion, providing an alert prompting a user to take corrective action,
wherein the corrective action is instructed in the alert to be taken during the test cycle without having to reinitiate the test cycle including the performance of the hematocrit analysis.

US Pat. No. 10,188,324

INFORMATION PROCESSING DEVICE, SENSOR DEVICE, INFORMATION PROCESSING SYSTEM, AND STORAGE MEDIUM

SONY CORPORATION, Tokyo ...

1. An information processing system comprising:a shock sensor;
processing circuitry configured to, for each of plural shock events,
receive input data from the shock sensor which outputs data defining a respective shock event,
receive time-series data output from a motion sensor that senses motion of an object, the shock sensor having a greater dynamic range in acceleration than the motion sensor,
set a length of a pre-shock portion of a target segment of the time-series data as a length of the longest pre-shock portion among plural predetermined motion patterns,
set a length of a post-shock portion of the target segment as a length of the longest post-shock portion among the plural predetermined motion patterns,
identify the target segment according to the defined respective shock event and the set lengths of the pre-shock portion and the post-shock portion,
identify an impact position on the object, and
identify the motion of the object as one of the plural predetermined motion patterns based on the identified target segment of the time-series data and a stored dictionary defining each of the plural predetermined motion patterns; and
a display configured to notify a user of the identified one of the plural predetermined motion patterns and display an impact position indicator on the object which is in an orientation corresponding to an actual orientation of the object at a time of impact based on the identified one of the plural predetermined motion patterns and the identified impact position.

US Pat. No. 10,188,319

METHOD OF PRODUCING A FOOT ORTHOTIC THROUGH 3D PRINTING USING FOOT PRESSURE MEASUREMENTS AND MATERIAL HARDNESS AND/OR STRUCTURE TO UNLOAD FOOT PRESSURE

AETREX WORLDWIDE, INC., ...

1. A method for 3D-printing an orthotic or insole, the method comprising:receiving pressure-point data or information of a foot using a pressure-analysis device;
generating 3D printer input data or information for configuring a 3D printing device to print the orthotic or insole comprising a plurality of compression cells at particular locations of the orthotic or insole correlated to locations represented by the pressure-point data or information of the foot, each compression cell having a physical structure or material adapted to produce an underfoot pressure response based on a measured pressure at a corresponding location represented by the pressure-point data or information; and
causing the 3D printing device to print the orthotic or insole based on the generated 3D printer input data or information.

US Pat. No. 10,188,318

BREATH DELIVERY SYSTEM AND METHOD

Invoy Holdings, LLC, Ali...

1. A mouthpiece for use with a portable electronic analyzer for detecting an analyte in a breath sample from an individual, the mouthpiece comprising:a biosensor that detects the analyte and generates a signal, the biosensor including a chemically active area where a chemical reaction takes place;
a processor, the processor configured to communicate with the biosensor;
a hydration system that is activated by the processor and then causes a plunger to release a liquid to the chemically active area of the biosensor to at least one of enhance, enable, and facilitate the chemical reaction;
a liquid sensor that determines if the liquid was delivered to the chemically active area, the liquid sensor configured to communicate with one or more of the biosensor, the processor, and the hydration system; and
hardware that transmits breath analyte data to the electronic analyzer.

US Pat. No. 10,188,309

SYSTEMS, ARTICLES, AND METHODS FOR ELECTROMYOGRAPHY SENSORS

NORTH INC., Kitchener (C...

1. A differential electromyography (“EMG”) sensor comprising:a first sensor electrode formed of an electrically conductive material;
an amplifier;
a first electrically conductive pathway that communicatively couples the first sensor electrode and the amplifier;
a first capacitor electrically coupled in series between the first sensor electrode and the amplifier in the first electrically conductive pathway;
a first resistor electrically coupled in series between the first sensor electrode and the amplifier in the first electrically conductive pathway;
a ground electrode formed of an electrically conductive material;
a second electrically conductive pathway that communicatively couples to the ground electrode;
a third electrically conductive pathway that communicatively couples the first electrically conductive pathway and the second electrically conductive pathway;
a second capacitor electrically coupled in the third electrically conductive pathway in between the first electrically conductive pathway and the second electrically conductive pathway;
a fourth electrically conductive pathway that communicatively couples the first electrically conductive pathway and the second electrically conductive pathway;
a second resistor electrically coupled in the fourth electrically conductive pathway in between the first electrically conductive pathway and the second electrically conductive pathway;
a second sensor electrode formed of an electrically conductive material;
a fifth electrically conductive pathway that communicatively couples the second sensor electrode and the amplifier;
a third capacitor electrically coupled in series between the second sensor electrode and the amplifier in the fifth electrically conductive pathway;
a third resistor electrically coupled in series between the second sensor electrode and the amplifier in the fifth electrically conductive pathway;
a sixth electrically conductive pathway that communicatively couples the fifth electrically conductive pathway and the second electrically conductive pathway;
a fourth capacitor electrically coupled in the sixth electrically conductive pathway in between the fifth electrically conductive pathway and the second electrically conductive pathway;
a seventh electrically conductive pathway that communicatively couples the fifth electrically conductive pathway and the second electrically conductive pathway; and
a fourth resistor electrically coupled in the seventh electrically conductive pathway in between the fifth electrically conductive pathway and the second electrically conductive pathway.

US Pat. No. 10,188,306

CARDIAC POTENTIAL DETECTION DEVICE AND CARDIAC POTENTIAL DETECTION METHOD

PANASONIC INTELLECTUAL PR...

1. A cardiac potential detection device for detecting R-waves from an electrocardiographic waveform, the cardiac potential detection device comprising:a plurality of electrodes;
a detector configured to detect an input voltage applied from the plurality of electrodes; and
a control unit configured to:
identify an R-wave candidate based on an R-wave detection threshold and a peak in the input voltage,
determine whether an absolute value of the input voltage is smaller than a predetermined threshold;
when the control unit determines that the absolute value of the input voltage has exceeded the predetermined threshold, calculate a detection-suspension period based on a time at which the input voltage exceeded the predetermined threshold, and suspend identifying of an R-wave candidate in the detection-suspension period, and
in a period excluding the detection-suspension period, identify the R-wave candidate as an R-wave when the input voltage does not exceed the predetermined threshold in a period from the R-wave candidate peak until a predetermined time expires.

US Pat. No. 10,188,302

METHODS FOR DYNAMIC VISUALIZATION OF CLINICAL PARAMETERS OVER TIME

The University of Vermont...

8. A non-transitory computer readable medium containing program instructions executable by a processor, the computer readable medium comprising:program instructions for generating a thrombin generation profile of a subject from measurements of the concentrations of factors II, V, VII/VIIa, VIII, IX, and X, tissue factor pathway inhibitor (TFPI), protein C (PC), and antithrombin (AT) in a biological sample from the subject;
program instructions for obtaining the parameters: maximum level of thrombin generation, maximum rate of thrombin generation, total thrombin generated, and clot time, the parameters are derived from the measurements of factors II, V, VII/VIIa, VIII, IX, and X, TFPI, PC, and AT; and
program instructions for determining the propensity of the patient for blood clotting and bleeding, the determination is based on the parameters; and
program instructions for displaying the thrombin generation profile in a visual form;
wherein a thrombin generation profile comprising a greater than 3-fold decrease in clot time and greater than 3-fold increase in maximum level of thrombin generation, maximum rate of thrombin generation, and total thrombin generated, relative to a respective reference for each of said parameters comprising the thrombin generation profile, indicates a propensity of the subject for blood clotting; and
wherein a thrombin generation profile comprising a greater than 3-fold increase in clot time and a greater than 3-fold decrease in maximum level of thrombin generation, maximum rate of thrombin generation, and total thrombin generated, relative to the respective reference for each of said parameters comprising the thrombin generation profile, indicates a propensity of the subject for bleeding.

US Pat. No. 10,188,298

OPTICAL SPECULUM

Illumigyn Ltd., Neve Ila...

1. A system for direct imaging, diagnosing and removing of abnormal cells in a target tissue, comprising:a disposable optical speculum;
an image acquisition system having the speculum assembled on and mechanically secured thereto, the image acquisition system arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets;
an image analysis and control unit in communication with the image acquisition system, the image analysis and control unit analyzing the data sets and applying algorithms to the data sets for diagnosing abnormal cells; and
a detector for warning of undesired stray light generated by improper assembly of the disposable optical speculum to the image acquisition system.

US Pat. No. 10,188,297

INTRA-OPERATIVE MOLECULAR IMAGING

Case Western Reserve Univ...

1. A system for detecting tumor margins, comprising:a topical protease-specific, near infrared fluorescence (NIRF) imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, NIRF imaging probe, wherein the protease-specific, NIRF imaging probe is activated by binding to the enzyme secreted by the cancer cell;
means for topically administering the protease-specific, NIRF imaging probe to the cancer cell; and
an imaging device to detect activation of the protease-specific, NIRF imaging probe administered to the cancer cell to detect tumor margins.

US Pat. No. 10,188,296

WIRELESS PATIENT MONITORING DEVICE

Masimo Corporation, Irvi...

1. A method of wirelessly monitoring physiological information, the method comprising:providing a battery including a data storage component;
connecting the battery to a bedside monitor;
recharging the battery via the bedside monitor;
upon connecting the battery to the bedside monitor, transferring wireless communication configuration data from the bedside monitor to the data storage component via a hard wired connection;
disconnecting the battery from the bedside monitor;
connecting the disconnected battery to a wireless monitor;
powering the wireless monitor with the battery;
upon connecting the disconnected battery to the wireless monitor, transferring the wireless communication configuration data from the data storage component to the wireless monitor;
reconfiguring wireless communication parameters of the wireless monitor according to the wireless communication configuration data when the battery is connected to the wireless monitor;
establishing wireless communication between the wireless monitor and the bedside monitor using the wireless communication configuration data;
obtaining physiological information from one or more optical sensors using the wireless monitor powered by the battery; and
transmitting physiological data reflective of the physiological information from the wireless monitor to the bedside monitor.

US Pat. No. 10,188,295

INTEGRATED SENSOR NETWORK METHODS AND SYSTEMS

The Curators of the Unive...

1. A method comprising:processing sensor data from a plurality of motion sensors and a bed sensor deployed in a living unit for a first time period to establish a frame of reference for an activity pattern by a person residing in the living unit, wherein the activity pattern frame of reference represents a health condition of a person residing in the living unit, wherein the processed sensor data for the first time period comprises a plurality of data values corresponding to a plurality of subintervals within the first time period, wherein each subinterval data value represents (1) a total number of sensor hits during that subinterval of the first time period or (2) a total time for sensor firings during that subinterval of the first time period, and wherein the activity pattern frame of reference comprises a statistical value about the subinterval data values over the first time period;
computing a standard deviation for the processed sensor data over the first time period based on the subinterval data values;
defining a statistical parameter threshold, wherein the statistical parameter threshold comprises a defined number of the standard deviations;
processing additional sensor data from the plurality of motion sensors and the bed sensor deployed in the living unit for a second time period, the second time period occurring after the first time period;
computing a value for the activity pattern for the second time period based on the processed additional sensor data, the computed activity pattern value of the second time period also representing a health condition of the person, wherein the computed activity pattern value comprises (1) data about a total number of sensor hits during the second time period if the activity pattern frame of reference is based on the total number of sensor hits during the first time period or (2) data about a total time for sensor firings during the second time period if the activity pattern frame of reference is based on the total time for sensor firings during the first time period;
comparing the computed activity pattern value with the activity pattern frame of reference and the defined statistical parameter threshold to determine whether the computed activity pattern value deviates from the activity pattern frame of reference by more than the defined number of the standard deviations;
generating an alert based on a determination that the computed activity pattern value deviates from the activity pattern frame of reference by more than the defined number of standard deviations;
receiving a feedback response to the alert, the feedback response including feedback regarding clinical relevance of the alert; and
adjusting the defined number of the standard deviations for the statistical parameter threshold to a different defined number of the standard deviations based on the feedback response to the alert.

US Pat. No. 10,188,290

SYSTEM AND METHOD FOR TRACKING MOTION

StereoVision Imaging, Inc...

1. A system for determining motion of a target, the system comprising:a video imaging system configured to capture a plurality of images of the target;
a lidar system configured to generate a range measurement and a Doppler velocity measurement for each of a plurality of points on the target; and
a processor configured to:
determine, from the plurality of images of the target, at least one first aspect of motion of the target based on the plurality of images of the target,
determine, from the range measurement and the Doppler velocity measurement for each of the plurality of points on the target, at least one second aspect of motion of the target, wherein the at least one first aspect of motion of the target is orthogonal to the at least one second aspect of motion of the target, and
combine the at least one first aspect of motion of the target determined from the plurality of images of the target and the at least one second aspect of motion of the target determined from the range measurement and the Doppler velocity measurement for each of the plurality of points on the target to determine the motion of the target.

US Pat. No. 10,188,288

INFORMATION SYSTEM AND METHOD FOR PROVIDING INFORMATION USING A HOLOGRAPHIC ELEMENT

Apple Inc., Cupertino, C...

1. A light-based information system, comprising:a first holographic element positioned to refract light, at a first one or more characteristic discrete wavelengths, incident from an environment, wherein the first one or more characteristic discrete wavelengths correspond to a refraction on a first concave side of a first surface constructed according to a curvature of a first rotationally symmetrical ellipsoid;
an optical scanning device positioned to detect the refracted light from the first holographic element and to generate a perceived field of vision;
an optical projection device positioned to receive the perceived field of vision and to produce a modified perceived field of vision; and
a second holographic element positioned to refract the modified perceived field of vision, at a second one or more characteristic discrete wavelengths, so as to generate an optical output, wherein the second one or more characteristic discrete wavelengths correspond to a refraction on a second concave side of a second surface constructed according to a curvature of a second rotationally symmetrical ellipsoid.

US Pat. No. 10,188,286

TOMOGRAPHIC IMAGE CAPTURING DEVICE

KOWA COMPANY, LTD., (JP)...

1. A tomographic image capturing device comprising:a tomographic image capturing means that scans measurement light on a subject's eye fundus to capture tomographic images of the subject's eye fundus; and
an image processing means that compresses a picture of the captured tomographic images in a scan direction to generate a new tomographic picture.

US Pat. No. 10,188,273

BIOLOGICAL NAVIGATION DEVICE

LOMA VISTA MEDICAL, INC.,...

1. A device for navigation through a biological anatomy, the device comprising:a tube configured to be advanced through the biological anatomy, the tube having a tube lumen therein;
a steering portion configured to bend to orient the device, said steering portion comprising an actuator for controlling the steering portion;
a reciprocating portion comprising a first tubular reciprocating element and a second tubular reciprocating element, the first tubular reciprocating element attached to a distal end of the steering portion, the second tubular reciprocating element mounted to and surrounding the first tubular reciprocating element, wherein an entirety of the second tubular reciprocating element is configured to longitudinally translate relative to the first tubular reciprocating element, wherein the second tubular reciprocating element remains coaxial with the first tubular reciprocating element during longitudinal translation of the second tubular reciprocating element relative to the first reciprocating element;
a visualization element for visualizing the biological anatomy; and
a distal tip at a distal end of the second tubular reciprocating element having a tip lumen therein continuous with the tube lumen, the tip lumen configured to hold the visualization element therein;
wherein longitudinal translation of the second tubular reciprocating element causes corresponding longitudinal translation of the visualization element held within the tip lumen of the distal tip.

US Pat. No. 10,188,269

MANUFACTURING METHOD FOR IMAGE PICKUP UNIT AND IMAGE PICKUP UNIT

OLYMPUS CORPORATION, Tok...

1. A method comprising:bonding lens wafers comprising optical components to form a lens unit wafer comprising lens units;
bonding a bending optical element wafer comprising bending optical elements to a first surface of the lens unit wafer to form an optical unit wafer such that the bending optical elements are respectively opposed to the lens units to arrange respective inclined planes of the bending optical elements to be inclined relative to the first surface of the lens unit wafer to refract light beams emitted from the lens units towards respective emission surfaces of the bending optical elements;
separating and individualizing the optical unit wafer for each of the lens units and the bending optical elements to manufacture optical units; and
respectively bonding solid-state image pickup devices to the emission surfaces of the bending optical elements of the optical units.

US Pat. No. 10,188,268

ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. An endoscope comprising:an insertion portion configured to be inserted into a subject;
a distal end portion disposed at a distal end of the insertion portion and including a housing part having a recess and an opening part that opens toward a distal end direction;
a tube having a tubular shape disposed in the insertion portion and formed of a flexible material;
an exit member fitted to a peripheral edge of the opening part in a liquid-tight manner in the housing part of the distal end portion, including an opening through which a treatment instrument protrudes, and forming a treatment instrument guiding-out path into which the treatment instrument is inserted when the opening is connected so as to communicate with the tube; and
an adjusting portion configured to change a protruding direction of the treatment instrument protruding from the opening of the exit member by changing a tilt angle of the treatment instrument guiding-out path by bending the tube connected to the opening of the exit member
wherein the adjusting portion comprises: a transferring portion made of a bar member, the bar member including a rotation shaft rotatable supported in the distal end portion and a contact portion that is in contact with an outer surface of the tube; and
an operation wire one end of which is connected between the rotation shaft and the contact portion of the bar member, the operation wire being configured to rotate the transferring portion by another end of the operation wire being moved forward and backward, to bend the tube and change the tilt angle of the treatment instrument guiding-out path.

US Pat. No. 10,188,262

DISHWASHER COMPRISING A SORPTION DRYING MACHINE

1. A dishwasher, comprising:a washing container;
an air-guiding channel to generate an air flow;
a sorption drying system to dry items to be washed, the sorption drying system having a sorption container with reversibly dehydratable sorption material, the sorption container connected to the washing container by the air-guiding channel; and
a heater disposed in the sorption container and arranged upstream of the reversibly dehydratable sorption material for desorption of the reversibly dehydratable sorption material,
wherein the air-guiding channel includes an inlet connecting piece connected to the sorption container and which diverts incoming air flow from an inflow direction by between 45° to 135° into a through-flow direction through the heater and the reversibly dehydratable sorption material,
wherein the through-flow direction through the heater and through the reversibly dehydratable sorption material is the same direction, such that the through-flow direction runs from a bottom portion to a top portion of the sorption container, and
wherein the dishwasher is configured to control a ratio of a heat output of the heater and an air volume flow of the air flow which flows through the sorption material to be between 100 W sec/l and 1250 W sec/l.

US Pat. No. 10,188,259

PUMP AND DISHWASHER PROVIDED WITH PUMP

LG ELECTRONICS INC., Seo...

1. A dishwasher comprising:a tub providing a washing space;
a rack located inside the tub and configured to receive washing targets;
a spray arm configured to spray water to the rack;
a sump in which the water is received;
an inlet chamber providing a space into which the water from the sump is supplied;
an outlet chamber connected with the inlet chamber and configured to guide the water from the inlet chamber to the spray arm;
an impeller located in the outlet chamber and configured to move the water to the spray arm;
a first housing fixed on the outlet chamber;
a rotor rotatably provided inside the first housing;
a rotation shaft passing through the outlet chamber, the rotation shaft connecting the rotor with the impeller;
a magnetic field formation unit surrounding the first housing, the magnetic field formation unit configured to produce a rotating magnetic field to rotate the rotor;
a friction bearing passing through the outlet chamber, the friction bearing rotatably supporting the rotation shaft;
an outlet path connecting the inside of the first housing with the outlet chamber;
a spacer through which the rotation shaft passes arranged to maintain a spacing between the rotor and the friction bearing; and
a guide path provided in the spacer for guiding water supplied into a space formed between the rotation shaft and the friction bearing to a contact surface between the spacer and the friction bearing,
wherein a rotational axis of the rotation shaft is perpendicular to a horizontal surface to prevent water from contacting the rotor.

US Pat. No. 10,188,244

DISPENSER AND METHOD OF REPLENISHING A DISPENSER

1. A dispenser for dispensing a sheet of web material from a stack of folded web material, the dispenser comprising:a web material storage section arranged to hold and support the stack of folded web material, in a generally vertical direction during dispensing of the web material;
the web material storage section comprising
an upper end portion from which the web material is arranged to be lead for dispensing thereof,
a lower end portion, opposite to the upper end portion and being arranged to support the stack of folded web material in said generally vertical direction, at least when the dispenser is in said dispensing position,
said upper end portion and lower end portion being arranged in a fixed spatial relationship;
wherein:
the lower end portion of the web material storage section comprises
a loading opening and
a supporting arrangement, arranged to be movable between
a support position wherein the supporting arrangement extends at least partially over said loading opening enabling said support of the stack of folded web material, and
an insert position, wherein the supporting arrangement is at least partially removed from the loading opening;
wherein said supporting arrangement is arranged to be movable from said support position to said insert position by pushing a stack to be introduced in the loading opening towards the supporting arrangement in a direction towards the upper end portion of the web material storage section.

US Pat. No. 10,188,241

DISPENSER ASSEMBLY

Vi-Jon, Inc., St. Louis,...

1. A dispenser assembly for dispensing a product, the dispenser assembly comprising:a bottle configured to store the product, the bottle comprising a back wall, the back wall comprising:
a substantially flat surface;
an angled surface extending outwards from the flat surface; and
an extension portion extending outwards from the flat surface, the extension portion having a width less than a width of the flat surface; and
a battery holder, the battery holder comprising:
a housing; and
a plurality of batteries contained in the housing,
wherein the battery holder is positioned adjacent the flat surface of the back wall of the bottle and below the angled surface of the back wall; and
wherein the housing of the battery holder comprises an intermediate wall separating laterally adjacent batteries, the intermediate wall comprising an angled portion that accommodates the extension portion of the bottle back wall.

US Pat. No. 10,188,232

DECORATIVE ARTICLE WITH RECEIVING MEMBER

Hee Kyung Lee, Suwon-si ...

1. A decorative article comprising:a base plate having at least one hanging elongate slot defined therein; and
a receiving member including a single first plate, at least two second plates, and a hanger, wherein the first plate is parallel to the base plate, each of the at least two second plates is non-parallel to the base plate and is coupled to the first plate to define an inner space and a top opening in the receiving member, and the hanger protrudes from the first plate along a top edge of the first plate, wherein the hanger is fitted into the hanging elongate slot to secure the receiving member to the base plate,
wherein the base plate has at least one decorative elongate slot defined therein,
wherein the at least one decorative elongate slot is adjacent to the at least one hanging elongate slot in a non-contacting manner to form a polygonal shape together with the at least one hanging elongate slot,
wherein the first plate falls within the polygonal shape defined by the least one hanging elongate slot and the at least one decorative elongate slot, and sides of the first plate are configured to correspond to the least one hanging elongate slot and the at least one decorative elongate slot such that the first plate has a geometrical shape substantially identical with the polygonal shape.

US Pat. No. 10,188,228

PILLOW WITH GUSSET OF OPEN CELL CONSTRUCTION

Bedgear, LLC, Farmingdal...

1. A pillow comprising:a cover having opposing first and second panels and a gusset joining the first panel with the second panel;
an inner cover disposed within the cover; and
a fill material disposed within the cover,
wherein the gusset has a first porosity, the panels each have a second porosity and the inner cover has a third porosity, the second porosity being different than the first porosity and the third porosity, and the third porosity being different than the first porosity, the second porosity being greater than the third porosity.

US Pat. No. 10,188,215

LOUNGE ASSEMBLIES FOR SUPPORTING PORTABLE ELECTRONIC DEVICES

Steelcase Inc., Grand Ra...

20. A hood assembly for supporting a portable electronic device having a display screen in a viewable position, the assembly comprising:a hood coupled to a base, the hood including a wall structure that includes an internal surface that forms a substantially downwardly opening cavity, the cavity including a front portion and a rear portion, the cavity opening circumscribed by a lower edge that has a front edge portion adjacent the front portion of the cavity;
a support device supported within the hood and adjacent the front edge portion, the support device configured to receive and support the portable electronic device with the device display screen disposed at an oblique angle to the internal surface such that the display screen is facing and in a line of sight of a user within the hood and blocked from a line of sight from outside of the hood when the hood is in a viewing position; and
a communications device provided in at least one of the hood and the base, and wherein the communications device is configured to communicate with the portable electronic device
wherein the communications device comprises a wireless transceiver coupled within the hood, the transceiver having a sensing field restricted to the space of the cavity.

US Pat. No. 10,188,209

SECURING DEVICE FOR DETACHABLY SECURING A FRONT PANEL ON A DRAWER

Julius Blum GmbH, Hoechs...

1. A securing device for releasably securing a front panel to a drawer, comprising:a furniture fitting to be pre-fitted to the front panel;
a catching device to be connected to the drawer, the catching device configured such that, upon insertion of the furniture fitting, the catching device automatically holds the furniture fitting, and the catching device having a moveable catching element, and
a locking device configured to prevent unintentional release of the furniture fitting from the securing device,
wherein the locking device has a moveable locking element separate from the catching element and configured to bear against the pre-fittable furniture fitting in a locked position, the catching element and the separate locking element being motionally coupled, and
wherein the securing device further comprises an adjusting element fixed to the catching element to couple the motion of the catching element to the motion of the locking element, the adjusting element engaging into an opening in the locking element.

US Pat. No. 10,188,208

DRIVE MECHANISM FOR A MOVABLE FURNITURE PART

Julius Blum GmbH, Hoechs...

1. A drive device for moving a movable furniture part, the drive device comprising:an entrainment member configured to be mounted to one of a furniture carcass and the movable furniture part;
a force-actuated drive element configured to be mounted to the other one of the furniture carcass and the movable furniture part so as to be movable in a drive movement direction, the drive element having a drive limit stop by which the entrainment member is moved during a drive movement in the drive movement direction, and the drive element including a passing ramp on a side facing away from the drive limit stop, the passing ramp being configured to allow the entrainment member to pass over the drive element in the drive movement direction; and
a catch lever for catching the entrainment member, the catch lever facing towards the drive limit stop such that the entrainment member is configured to be positioned between the drive limit stop and the catch lever during the drive movement in the drive movement direction, and the catch lever being pivotably supported on a base part of the drive element such that a distance between the catch lever and the drive limit stop changes as the catch lever is pivoted.

US Pat. No. 10,188,206

CONVERTIBLE FURNITURE UNIT, SLAT FOR USE IN FORMING A FURNITURE UNIT AND METHOD OF USING A CONVERTIBLE FURNITURE UNIT

DESIGNARIUM INC., Laval ...

1. A convertible furniture unit comprising a hinge member pivotally linking first and second furniture portions to allow said first and second furniture portions to relatively pivot relative to each other to adopt a number of different angular relative positions, and a locking mechanism to releasably lock said first and second furniture portions in a given angular relative position, said first and second furniture portions each comprising a number of slats that are intermeshed with and are slidable between the slats of the other one of said first and second furniture portions, each said slat comprising a hinge portion pivotally attached to said hinge member, an arm extending away from said hinge portion and a free extremity opposite said hinge portion, said first and second furniture portions being capable of adopting at least:a first position wherein said arms of said slats of said first furniture portion extend away from said hinge member and between two adjacent said arms of said slats of said second furniture portion; and
a second position in which said arms of said slats of said first furniture portion extend away from said hinge member and away from said arms of said slats of said second furniture portion without extending between two adjacent said arms of said slats of said second furniture portion;wherein said first and second positions of said first and second furniture portions are both operable for use of said furniture unit by a user.

US Pat. No. 10,188,204

DESK WITH STABILITY FEATURE

Argosy Console, Inc., El...

1. A desk comprising:a desktop defining a height configured to be adjusted between a lower position and an upper position;
a leg comprising an attachment portion and a foot portion, the attachment portion of the leg secured to the desktop and extending away from the desktop, the attachment portion of the leg configured to move with respect to the foot portion of the leg along an axis of the leg to adjust a height of the desktop about and between the lower position and the upper position, the foot portion of the leg defining a bottom end of the desk; and
a gas spring extending from the leg to the desktop, the gas spring angled with respect to the leg by an angle of at least 5 degrees and with respect to the desktop by an angle of at least 5 degrees, the gas spring configured to dampen movement of the desk when a force comprising a horizontal component is applied to an edge of the desktop when the desktop is in the upper position.

US Pat. No. 10,188,191

LIP EXFOLIATING DEVICE

1. A lip exfoliator comprising:an exfoliant comprising an active surface, wherein the active surface is composed of an insoluble dry abrasive material comprising a binding agent that holds in place exfoliating particles;
a bottom section comprising an attachment surface;
a binding mechanism configured to attach the exfoliant to the bottom section, wherein the binding mechanism comprises a solid body that at least partially covers the exfoliant; and
a cap configured to attach to the solid body, wherein the cap covers the active surface when attached to the solid body, and
wherein the attachment surface is adapted to attach to an end of a lip balm by an adhesive.

US Pat. No. 10,188,184

FOLDING SUITCASE

VOYLUX COMPANY LIMITED, ...

1. A folding suitcase, comprising:a back case component;
a front lid component;
a peripheral side wall component with two sides which are opposite to each other, an edge of the back case component and an edge of the front lid component being connected to the two sides of the peripheral side wall component respectively, thereby forming an accommodating space which is for being covered selectively, the peripheral side wall component having a plurality of first sidewall parts, a plurality of second sidewall parts and a plurality of bending parts connected to the plurality of first sidewall parts and the plurality of second sidewall parts, and the plurality of bending parts being bendable to allow the plurality of first sidewall parts and the plurality of second sidewall parts to be folded oppositely or erected on the back case component, each of the plurality of bending parts comprising a bending section and a link-up section, the plurality of bending sections being connected to the plurality of first sidewall parts, and the link-up section of each of the plurality of bending parts being connected to the plurality of second sidewall parts;
at least one fold-resisting component, the at least one fold-resisting component being elastic and comprising a combined part and an extension part which are connected to each other, the combined part being disposed at one of the plurality of first sidewall parts;
two bendable fixing components, each of the two bendable fixing component having a fixing section and a suspension section which are connected with each other, the two fixing sections being located on two of the plurality of second sidewall parts of the peripheral side wall component, respectively, the two suspension sections being disposed across the bending sections of the bending parts, respectively;
two restoring components, located at an inner side of the peripheral side wall component by the two bendable fixing components respectively with each of the restoring components being disposed across at least one bending part, the two restoring components being elastic, and an elasticity of the at least one fold-resisting component being greater than an elasticity of the two restoring components;
an elastic component, the two suspension sections being connected to two ends of the elastic component, respectively;
a first combination component, disposed at the bending part close to the first sidewall part at which the combined part is disposed; and
a second combination component, disposed at the extension part of the at least one fold-resisting component, the extension part of the at least one fold-resisting component being detachably disposed at the link-up section by the first combination component and the second combination component, such that the fold-resisting component is disposed across the bending section, the first combination component and the second combination component being two attached components with hooks and loops and the first combination component being detachably combined with the second combination component.

US Pat. No. 10,188,159

APPARATUS, SYSTEM, AND METHOD FOR REDUCING HEAD OR NECK TRAUMA

ARMOUR TECHNOLOGIES, INC....

1. An apparatus for reducing trauma in the head or neck of a living being caused by acceleration of the head relative to the torso of the living being within a range of motion, the apparatus comprising:a support configured to engage at least one of the head, neck, and shoulder of the living being; and
a physiological damper including at least one electrode associated with the support and an actuator coupled to actuate the electrode, wherein the electrode is positioned to stimulate a muscle of the living being to (1) increase resistance to the motion provided by the muscle in response to a sensed position, speed or acceleration of the head of the living being, or (2) strengthen the muscle of the living being to counteract a force applied to the head of the living being.

US Pat. No. 10,188,146

ELECTRONIC CIGARETTE AND ATOMIZER DEVICE AND ATOMIZER ASSEMBLY THEREOF

SHENZHEN SMOORE TECHNOLOG...

1. An atomizer device (10), comprising an atomizer assembly (12); the atomizer assembly (12) comprising a connection tube (123) and an inner core assembly (124) arranged in the connection tube (123); the connection tube (123) defining a liquid inlet hole (1233) allowing liquid solution to flow into the connection tube (123); the inner core assembly (124) comprising a heater (1242) for heating and atomizing the liquid solution flowing into the connection tube (123); wherein the connection tube (123) comprises a first connection member (1231) and a second connection member (1232) detachably connected with the first connection member (1231); and the first connection member (1231) and the second connection member (1232) defines a receiving space in which the inner core assembly (124) is detachably arranged; the atomizer assembly (12) further comprises a conducible atomizer base (121), and the connection tube (123) is detachably connected with the atomizer base (121); wherein the atomizer device (10) further comprises a liquid reservoir assembly (11); the atomizer assembly (12) is detachably connected with the liquid reservoir assembly (11), and the liquid reservoir assembly (11) forms a liquid reservoir chamber (A) for containing liquid solution, a liquid outlet (1113) allowing the liquid solution to flow out of the liquid reservoir chamber (A), and a blocker (115) blocking in the liquid outlet (1113); the atomizer assembly (12) is screwed to the liquid reservoir assembly (11) and is capable of driving the blocker (115) to rotate, thereby driving the blocker (115) to rotate to open the liquid outlet (1113) while being installed and driving the blocker (115) to rotate to close the liquid outlet (1113) while being removed; and the liquid outlet (1113) corresponds to the liquid inlet hole (1233) such that liquid solution can be injected into the connection tube (123) when the liquid outlet (1113) is opened.

US Pat. No. 10,188,138

SMOKING ARTICLE WITH MANUALLY RELEASABLE ODORANT

Philip Morris USA Inc., ...

1. An article comprising:a tobacco portion;
a filter connected axially aligned with and connected to the tobacco portion;
a tipping paper circumscribing at least a portion of the tobacco portion and at least a portion of the filter;
a first band on at least a portion of the tipping paper, the first band including,
a first layer of a first material over the tipping paper, and
a first plurality of microcapsules between the tipping paper and the first layer of material, the plurality of microcapsules being frangible; and
a second band on a second portion of the tipping paper, the second band including,
a second layer of a second material, and
a second plurality of microcapsules between the tipping paper and the second layer, the second plurality of microcapsules being frangible.

US Pat. No. 10,188,120

MULTIPLE DRAWER SMOKER

LANDMANN USA, Fairburn, ...

1. A smoking apparatus comprising a cabinet having side and rear walls, an upper smoking chamber with a front access door and a lower section having at least two independently operable drawers, one of said drawers disposed above the other and each of said drawers having a front panel with right and left side panels forming an enclosure, a handle attached to each of said front panels, said handles located outside said cabinet, one of said drawers configured to hold a flavoring material and the second drawer configured to hold a liquid, a support surface for each of said drawers secured to said side walls of said lower section, whereby said drawers can be moved into and out of said cabinet using said handles, and a heating element disposed within said cabinet.

US Pat. No. 10,188,107

SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES

HEINRICH HEINE UNIVERSITA...

1. A method of using at least one compound, a salt or solvate thereof as a C4 plant selective herbicide, comprising applying said compound, salt or solvate to a plant, wherein binding of said compound to the malate binding site of aphosphoenolpyruvate carboxylase from a C3 plant is inhibited, and wherein said compound has a structure according toformula (I)
wherein A iswherein R6, R7, R8, R9 and R10 are, independently of each other, selected from the group consisting of H, OH, carboxylic acid, ester, alkyl, alkoxy and halogen, or wherein two residues in ortho position to each other form a heterocyclic ring using —O—CH2—O— or —O—CH2—CH2—O, andB is
wherein R11, R12, R13, R14 and R15 are, independently of each other, selected from the group consisting of H, OH, carboxylic acid, ester, alkyl, alkoxy and halogen, or wherein two residues in ortho position to each other form a heterocyclic ring using —O—CH2—O— or —O—CH2—CH2—O—,
and wherein R1, R2, R3, R4 and R5 are, independently of each other H or an alkyl group,
and wherein integer i is 0 or 1,
and the bond (a) is a single or double bond,
and wherein in case (a) is a double bond, n is 0 and X is O or S, and wherein in case (a) is a single bond n is 1, and X is H or an alkyl group,
and wherein the bond (b) is a single or double bond, and wherein in case (b) is a double bond, m and p are 0, and wherein in case (b) is a single bond m and p are both 1,
and wherein said compound being capable of binding to the malate binding site comprised by a phosphoenolpyruvate carboxylase from a C4 plant, thereby inhibiting said phosphoenolpyruvate carboxylase.

US Pat. No. 10,188,091

PORTABLE LIGHT AND INSECT EXTERMINATION DEVICE

alliance sports group, I....

1. A handheld lighting apparatus, comprising:a top housing coupled to a first light source and an electrical grid configured to distribute a quantity of electricity to an object that contacts adjacent portions of the grid, the top housing being slidably mounted to a bottom housing having a cavity therein, the cavity being configured to receive the electrical grid assembly therein,
wherein the first light source emits light ranging from about 400 nm to about 720 nm in a first mode and light ranging from about 315 nm to about 400 nm in a second mode;
an enclosure disposed about the electrical grid assembly configured to permit passage of insects through portions of the enclosure;
a second light source disposed about the bottom housing configured to propagate light in a direction that is parallel to a longitudinal direction of the lighting apparatus;
a power source coupled to the first and second light source and the electric grid; and
a programmable logic control system coupled to a switch and the power source, the control system configured to operate the first light source such that light propagated from one or more LEDs of the first light source ranging from about 315 nm to about 400 nm is pulse width modulated at a rate greater than about 20 KHz while light propagated from one or more LEDs of the first light source ranging from about 400 nm to about 720 nm is not pulse width modulated or is pulse width modulated at a rate below 2 KHz.

US Pat. No. 10,188,088

FISH STRIKE INDICATING APPARATUS, SYSTEM AND METHOD FOR USE WITH AN ICE FISHING TIP-UP

Deep Freeze, LLC, Steven...

1. A fish strike indicating apparatus comprising:an enclosure configured to attach to an ice fishing tip-up flagpole, the enclosure comprising
a cylindrical mounting channel extending longitudinally along a first side of the enclosure, the cylindrical mounting channel adapted to securely receive the flagpole;
a transmitting apparatus disposed inside of the enclosure, wherein the transmitting apparatus is configured to transmit a wireless signal indicative of a fish strike to a mobile device; and
a receiving apparatus disposed inside of the enclosure, wherein the receiving apparatus is configured to receive a wireless signal from the mobile device.

US Pat. No. 10,188,086

INSECT PRODUCTION SYSTEMS AND METHODS

1. A method to separate crickets from a cricket and gas mixture, the method includes:(a) providing:
a separator having an input and an output, the input is configured to accept a cricket and gas mixture, the separator is configured to separate crickets from the cricket and gas mixture and output a cricket-depleted gas stream via said output, the cricket-depleted gas stream has a reduced amount of crickets relative to the cricket and gas mixture; and
(b) separating crickets from the cricket and gas mixture to form a cricket-depleted gas stream that has a reduced amount of crickets relative to the cricket and gas mixture.

US Pat. No. 10,188,085

SYSTEM AND METHODOLOGY FOR CULTURING COCHINEAL INSECTS ON AN ARTIFICIAL MEDIUM

SciConsult, Inc., Fort W...

1. A self-supporting mass, comprising:an artificial culture medium which contains a plant additive and which has been inoculated with a plurality of insects selected from the group consisting of the genus Dactylopius;
wherein said artificial culture medium further comprises a three-dimensional matrix.

US Pat. No. 10,188,084

INSECT PRODUCTION SYSTEMS AND METHODS

1. A insect breeding system comprising:a roller positioned along a conveyor path;
a breeding material positioned on the roller;
a water source positioned on the conveyor path to apply water to the breeding material;
a motor coupled to the roller to drive the roller and rotate the roller and move the breeding material along the conveyor path and past the water source; and
a sensor configured to analyze at least a portion of the breeding material;
wherein:
the sensor is selected from the group consisting of an optical sensor, a digital camera, a motion sensor, an active infrared sensor, a passive infrared sensor, a microwave motion sensor, a continuous wave radar motion sensor, a vibration motion sensor, an infrared (IR) sensor, an ultrasonic sensor, a proximity sensor, a touch sensor, a mass sensor, a laser sensor, and combinations thereof.

US Pat. No. 10,188,077

HANG-ON NATURAL WATER DRINKING SYSTEM

Ying Yeeh Enterprise Co.,...

1. A hang-on natural water drinking system, provided in form of a hang-on drinking system adapted to effectuate a natural water state, the hang-on drinking system comprising:a holder having a pipe segment;
a water-holding unit for holding drinking water and laterally provided with a connecting segment for drawing water off the water-holding unit, allowing the pipe segment to fit around the connecting segment; and
a drinking unit serving pets and comprising a basic drinking portion, a supporting portion, and a diverting portion, the basic drinking portion having an end extending to form a guide trough, the guide trough abutting against the connecting segment from below to guide water to the basic drinking portion, allowing water to go from an end of a submerged motor to the diverting portion coupled to the basic drinking portion, allowing the water in the diverting portion to flow across at least one blocking region defined at the diverting portion in a manner to enter a turbulent white-water drinking state, wherein the water not only enters the basic drinking portion to serve the pets, but is also driven by the submerged motor coupled to the basic drinking portion to move upward and get introduced into the diverting portion so that the water from the water-holding unit circulates through the drinking unit continuously.

US Pat. No. 10,188,048

SYSTEMS AND METHODS FOR MONITORING MOVEMENT OF DISEASE FIELD

BE SEEN BE SAFE LTD., To...

1. A method for monitoring movement of disease across agricultural areas of interest comprising:displaying, on a map of an application of a first device, at least one virtual zone corresponding to an agricultural geographic area of interest,
the at least one virtual zone defined by at least one geofence,
each virtual zone associated with a level of risk that indicates a likelihood of an outbreak of a disease detrimental to agriculture within the agricultural area of interest,
each virtual zone configured to receive access notification information from each geofence when tracked devices enter an area defined by that geofence,
the access information including the level of risk associated with the tracked devices, and
the level of risk associated with the virtual zone comprising a level of risk associated with the tracked devices that have entered an area defined by the virtual zone within a period of time associated with the disease; and
receiving an alert message associated with a level of risk when the first device is in proximity to a virtual zone associated with that level of risk, the alert message received prior to the first device entering the virtual zone.

US Pat. No. 10,188,045

APPARATUS, SYSTEM AND METHOD FOR ERADICATING SOIL-BORNE PESTS USING VARIABLE CONTROLLED ELECTRIC CURRENT

David Michael Flagler, S...

1. An apparatus for introducing electricity into soil to eradicate soil-borne pests, said apparatus comprising:a frame having a plurality of frame members;
a leading row supported by said frame, said leading row having a plurality of downwardly pointing ripper shanks, each of said ripper shanks configured to cut a path through the soil;
a trailing row supported by said frame behind said leading row, said trailing row having a plurality of downwardly disposed stinger shanks that each comprise at least one electrically conductive exterior surface, each of said stinger shanks being aligned with one of said ripper shanks so as to define a plurality of shank pairs therewith and to move through said path cut by said corresponding ripper shank;
a source of electricity electrically connected to each of said stinger shanks so as to transmit a quantity of electricity thereto;
a voltage controller electrically connected to said source of electricity and configured to select said quantity of electricity to be transmitted to each of said stinger shanks based on the condition of the soil; and
a probe row supported by said frame between said leading row and said trailing row, said probe row having a soil probe configured to move through one of said paths formed by said leading row, read the condition of the soil in said path and transmit a reading signal to said voltage controller, said voltage controller further configured to receive and process said reading signal to automatically determine said quantity of electricity required to be transmitted to each of said stinger shanks to effectively and efficiently eradicate the pests by continuously discharging electricity from said source of electricity into the soil from said stinger shanks as said stinger shanks move through the soil.

US Pat. No. 10,188,042

ROUND BALER WITH BALE WRAPPER

1. A round baler with a bale wrapper wherein the bale wrapper comprises:a bale wrapping unit which rotates about a vertical axis of rotation and has rotation arms which extend parallel to the axis of rotation and which support reels of wrapping material guided inside an action region of the bale wrapping unit extending transversely and longitudinally relative to the axis of rotation, wherein a delimiting rod linkage is arranged on the round baler or on the bale wrapper and extends at the back of the round baler and is capable of pivoting from an upper position located above the bale wrapping unit into a lower position located around the rear and sides of the bale wrapping unit, the delimiting rod linkage being narrower in the transverse direction of the round baler when in the upper position.

US Pat. No. 10,188,035

LOAD-BASED YIELD SENSOR

Intelligent Agricultural ...

5. A system for estimating the weight of a crop harvested in a harvesting machine including a grain elevator having a conveyor belt with upper and lower ends positioned within the harvesting machine and an on-board processor with a non-volatile memory, said processor controlling crop harvesting and weighing operations, which system comprises:first and second weight sensors operably connected at first and second sides of said conveyor belt upper end at approximately equal elevations;
each said weight sensor configured for providing an output corresponding to a portion of the conveyor belt weight on a respective conveyor belt upper end first or second side;
wherein said weight sensors comprise potentiometers configured for providing output corresponding to deflection of said conveyor belt upper end sides;
each said weight sensor output comprising an input to said processor;
said processor configured for processing data received from said weight sensors;
said processor configured for initializing with an empty conveyor belt weight;
said elevator configured for lifting said harvested crop within said harvesting machine;
each said weight sensor configured for providing an output to said processor comprising a loaded conveyor belt weight while said conveyor belt is lifting said harvested crop;
said processor configured for subtracting said empty conveyor belt weight from said loaded conveyor belt weight to determine a weight of harvested crop on each side of said conveyor belt;
said processor configured for providing output corresponding to said harvested crop weight;
said processor configured for adjusting crop harvesting parameters to compensate for asymmetrical weight conditions on said conveyor belt; and
wherein said crop harvesting parameters are selected from the group consisting of: harvesting machine speed; direction; crop quality; engine RPM; sieve spacing; harvester machine fan-rotor speed; and combinations thereof.
US Pat. No. 10,189,924

HIGH DENSITY ROTOMOLDING RESIN

NOVA Chemicals (Internati...

1. A polyethylene resin comprising from 0.7 to 1.2 weight % of 1-octene and the balance ethylene, having a density from 0.948 to 0.953 g/cc, a melt index determined according to ASTM1238 under a load of 2.16 kg at a temperature of 190° C. (I2) from 1.0 to 1.5 g/10 minutes; a melt index determined according to ASTM1238 under a load of 21.6 kg at a temperature of 190° C. (I21) from 32 to 55 g/10 minutes; a weight average molecular weight (Mw) determined by gel permeation chromatography from 95,000 to 120,000; a number average molecular weight determined by gel permeation chromatography (GPC) from 20,000 to 40,000; a z average molecular weight (Mz) from 240,000 to 360,000; an Mw/Mn from 2.7 to 4.3; an Mz/Mw from 2.5 to 3.5; and having a CBDI (50) from 80 to 95, the molecular weight distribution determined by GPC of said polymer being deconvoluted into at least two components comprising:from 20 to 40 weight % of a first component having a calculated weight average molecular weight (Mw) being from 200,000 to 250,000; a calculated number average molecular weight from 90,000 to 140,000; a z average molecular weight 390,000 to 520,000 and an estimated density from 0.921 to 0.930 g/cc;
from 60 to 80 weight % of a second component having a calculated weight average molecular weight (Mw) being from 20,000 to 57,000; a calculated number average molecular weight (Mn) from 10,000 to 27,000; a z average molecular weight from 30,000 to 72,000 and an estimated density from 0.948 to 0.953 g/cc, provided that the difference in calculated density between component two and component one is less than 0.030 g/cc.
US Pat. No. 10,190,180

COMPOSITIONS AND METHODS FOR AMPLIFYING AND CHARACTERIZING HCV NUCLEIC ACID

GEN-PROBE INCORPORATED, ...

1. A method for determining at least partial genotype information for hepatitis C virus type la (HCV-la) in a sample, the method comprising:(1) contacting a sample, said sample suspected of containing HCV-la, with
at least two amplification oligomers for amplifying at least one target region of an HCV-la target nucleic acid, wherein said at least one HCV-la target region is selected from the group consisting of
(a) a first target region comprising nucleotide positions 8522 to 9372 of SEQ ID NO:155 or the complement thereof, wherein if the first target region is amplified, then the at least two amplification oligomers comprise (i) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs:65, 43, and 34; and (ii) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs:69, 38, and 41;
(b) a second target region comprising nucleotide positions 7788 to 8838 of SEQ ID NO:155 or the complement thereof, wherein if the second target region is amplified, then the at least two amplification oligomers comprise (i) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 57, 63, and 28; and (ii) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 40, 35, and 42;
(c) a third target region comprising nucleotide positions 6966 to 7970 of SEQ ID NO:155 or the complement thereof, wherein if the third target region is amplified, then the at least two amplification oligomers comprise (i) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 60, 58, and 36; and (ii) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 31, 73, and 62;
(d) a fourth target region comprising nucleotide positions 6076 to 7117 of SEQ ID NO:155 or the complement thereof, wherein if the fourth target region is amplified, then the at least two amplification oligomers comprise (i) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 55, 70, and 29; and (ii) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs:46, 45, and 61;
(e) a fifth target region comprising nucleotide positions 5094 to 6304 of SEQ ID NO:155 or the complement thereof, wherein if the fifth target region is amplified, then the at least two amplification oligomers comprise (i) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 39, 44, and 68; and (ii) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 47, 51, and 59;
(f) a sixth target region comprising nucleotide positions 4258 to 5297 of SEQ ID NO:155 or the complement thereof, wherein if the sixth target region is amplified, then the at least two amplification oligomers comprise (i) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 52, 49, and 72; and (ii) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 37, 75, and 53; and
(g) a seventh target region comprising nucleotide positions 3434 to 4482 of SEQ ID NO:155 or the complement thereof, wherein if the seventh target region is amplified, then the at least two amplification oligomers comprise (i) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 77, 79, and 81; and (ii) at least one oligomer comprising a target-hybridizing sequence comprising a nucleotide sequence selected from SEQ ID NOs: 78, 80, and 71;
(2) performing at least one in vitro nucleic acid amplification reaction, wherein any HCV-la target nucleic acid present in said sample is used as a template for generating at least one amplification product corresponding to at least one of the first through seventh target regions; and
(3) detecting the nucleobase at one or more nucleotide positions within the at least one amplification product, thereby determining at least partial genotype information for the HCV-la in said sample.
US Pat. No. 10,188,135

METHOD FOR INDUCING SATIETY

Stokley-Van Camp, Inc., ...

1. A method comprising providing to a consumer a food product comprising, per a serving size of 40-80 grams dry weight or 177-354 mL liquid, protein and leucine, said protein being present in an amount of less than about 13.5 grams of total protein, and said leucine being present in an amount of between about 1.0 to about 3.5 grams of total leucine, said total leucine provided only by a combination of the total protein and a leucine-bound peptide composition, said total protein comprising protein from said leucine-bound peptide composition and one or more protein sources within the food product, said food product inducing satiety in the consumer.
US Pat. No. 10,188,139

ADDITIVES FOR TOBACCO CUT FILLER

Philip Morris USA Inc., ...

1. A method of reducing cytotoxicity and/or mutagenicity in tobacco smoke is provided comprising:applying a solution comprising a mixture of glycerin and a magnesium or calcium salt selected from the group consisting of magnesium nitrate, magnesium chloride, magnesium acetate, magnesium sulfate, calcium nitrate, calcium chloride, calcium acetate and mixtures thereof, onto tobacco cut filler to form a tobacco smoking mixture capable of producing tobacco smoke when burned;
forming a smoking article comprising a wrapper, the tobacco smoking mixture and a filter; and
burning the smoking article to produce tobacco smoke with reduced cytotoxicity and/or mutagenicity;
wherein the glycerin is present in an amount of about 8 to about 13% by weight of the tobacco smoking mixture, and wherein the mixture of glycerin and magnesium or calcium salt is present in an amount effective to reduce the cytotoxicity and/or the mutagenicity of the smoke produced from the tobacco smoking mixture upon burning.
US Pat. No. 10,189,933

METHOD FOR PRODUCING FUNCTIONALIZED THERMOPLASTIC ELASTOMERS

BYK-CHEMIE GMBH, Wesel (...

1. A process for preparing a functionalized thermoplastic elastomer based on particulate graft substrates selected from the group consisting of:(i) olefin block copolymers comprising 80 to 98 mass-% of ethylene- and 2 to 20 mass-% of C3- to C12-olefin units;
(ii) semi-crystalline copolymers of the composition 50 to 98 mass-% of propylene- and 2 to 50 mass-% of ethylene and/or C4- to C12-olefin and/or C4- to C12-diene units, and
(iii) cross-linked styrene/olefin/styrene block copolymers or cross-linked styrene/olefin block copolymers,
wherein in a fluid mixing reactor, is added:
0.1 to 15 mass parts of ?,?-ethylenically unsaturated compounds containing at least one functional monomer or a monomer mixture containing the at least one functional monomer, wherein the at least one functional monomer contains functional groups,
0.01 to 10 mass parts of at least one initiator forming free radicals with a 1-hour half-life temperature (THWZ/1h) between 50 and 200°, and
100 mass parts of the particulate graft substrate;
wherein the unsaturated compounds, the at least one initiator and particulate graft substrate are polymerized at reaction temperatures between 40° C. and the melting or softening temperature of the particulate graft substrate for a reaction time between 10 and 200 min in a solid-fluid phase, wherein a graft product having a grafted functional monomer is produced by such a solid state functionalization, which is used as a starting component for further processing, wherein during further processing:
100 mass parts of the graft product is mixed with: (i) between 0.1 and 60 mass parts of at least one other functional monomer; or (ii) between 0.1 and 60 mass parts of another monomer mixture containing the at least one other functional monomer and between 0.01 and 20 mass parts of at least one other initiator forming free radicals with a 1-hour half-life temperature (THWZ/1h) 80-240° C. producing a mixture; the mixture together with 100 to 4000 mass parts of an unmodified olefin elastomer, are continuously fed into an intake area of a reaction extruder via metering devices,
reactive extrusion from the reactor extruder is carried out at temperatures above melting or softening point of the unmodified olefin elastomer, and
the functionalized thermoplastic elastomer is continuously discharged from the reaction extruder.
US Pat. No. 10,189,934

PREPARATION OF MOLECULARLY IMPRINTED POLYMERS

MIP DIAGNOSTICS LIMITED, ...

1. A process for the preparation of a solution or colloidal suspension of molecularly imprinted polymer (“MIP”) particles comprising the steps of:(a) providing a carrier substance having a template material immobilized on it so the template is exposed at the carrier substance surface;
(b) providing a polymerizable composition in contact with said template;
(c) effecting controlled polymerization of said polymerizable composition in contact with said template by using a method selected from radical polymerization, optionally controlled living radical polymerization (LRP); living anionic polymerization; living cationic polymerization; and controlled polycondensation; iniferter-mediated polymerization, nitroxide-mediated polymerization (NMP), atom-transfer radical polymerization (ATRP) and reversible addition-fragmentation chain-transfer polymerization (RAFT), said polymerization being terminated when MIP particles of less than 1 micrometer have been formed; and
(d) separating said MIP particles from said template by washing and/or eluting thereby forming said solution or colloidal suspension, wherein said carrier substance and said immobilized template can be reused in additional controlled polymerizations of the type set forth in step (c) above.
US Pat. No. 10,188,662

SOFT LOZENGE COMPOSITIONS

Patheon Softgels, Inc., ...

1. An oral, slow releasing, solid, soft lozenge pharmaceutical composition comprising:(a) about 10% to about 40% by mass of one or more gelatins;
(b) about 1% to about 5% by mass polyethylene oxide having a molecular weight (My) of about 900,000 to about 8,000,000;
(c) about 5% to about 20% by mass of glycerol, sorbitol, mannitol, maltitol, xylitol, or combinations thereof;
(d) about 20% to about 60% by mass of maltitol, xylitol, mannitol, sucralose, aspartame, stevia, or a combination thereof;
(e) about 0.1% to about 5% by mass of one or more organic acids;
(f) 0.005% to about 5% by mass of one or more active pharmaceutical ingredients; and
(g) water;
wherein the composition orally disintegrates within about 30-45 minutes upon oral administration to a subject in need thereof.
US Pat. No. 10,188,664

INJECTABLE PHARMACEUTICAL COMPOSITIONS COMPRISING A CYCLODEXTRIN A HYDROPHOBIC DRUG, A CO-SOLVENT, AND A PRESERVATIVE

JUROX PTY LTD, South Wal...

1. An injectable pharmaceutical composition, in the form of a solution, wherein the injectable pharmaceutical composition complies with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the A criteria for parenterals, comprising:1% w/v to 5% w/v alfaxalone,
8% w/v to 40% w/v 2-hydroxypropyl-?-cyclodextrin,
0.1% w/v to 0.15% w/v chlorocresol,
15% w/v ethanol, and
optionally a phosphate based buffer to provide a pH in a range of 6.0 to 7.5.
US Pat. No. 10,189,178

METHOD FOR PRODUCING WOOD MATERIAL PANELS, IN PARTICULAR OSB WOOD MATERIAL PANELS, AND WOOD MATERIAL PANEL THAT CAN BE PRODUCED IN ACCORDANCE WITH SAID METHOD

SWISS KRONO Tec AG, Luce...

1. A method of producing an OSB wood-base panel, comprising the steps of:a) providing wood strands;
b) applying at least one adhesive system to the wood strands, wherein the adhesive system comprises:
solely a polyurethane adhesive, and
nanoparticles below 500 nm, wherein at least one nanoparticle is modified with at least one compound of general formula (I)
RaSiX(4-a)  (I),
or of general formula (II)
ObXc(OH)dReSiO(4-b-c-d-e)/2  (II),
where
X is H, OH or a hydrolyzable moiety selected from the group consisting of: halogen, alkoxy, carboxyl, amino, monoalkylamino or dialkylamino, aryloxy, acyloxy, alkylcarbonyl,
R is a nonhydrolyzable organic moiety R selected from the group consisting of: substituted and unsubstituted alkyl, substituted and unsubstituted aryl, substituted and unsubstituted alkenyl, substituted and unsubstituted alkynyl, substituted and unsubstituted cycloalkyl, which may each be interrupted by —O— or —NH—, and
wherein R may include at least one functional group Q selected from a group containing an epoxy, hydroxyl, ether, amino, monoalkylamino, dialkylamino, substituted and unsubstituted anilino, amide, carboxyl, acryloyl, acryloyloxy, methacryloyl, methacryloyloxy, mercapto, cyano, alkoxy, isocyano, aldehyde, alkylcarbonyl, acid anhydride and/or phosphoric acid group,
a is =0, 1, 2, 3,
b, c, d are=0 or 1, and
e is =1, 2, 3;
wherein the adhesive system is admixed to the wood strands in an amount between 1.0 and 2.5 wt % based on the wood strands, and
c) pressing the wood strands admixed with the adhesive system to form the wood-base panel.
US Pat. No. 10,188,672

COMPOSITIONS AND METHODS FOR TISSUE REGENERATION

Orbis Health Solutions LL...

1. A composition consisting essentially of tetraethyl orthosilicate and at least one oil selected from the group consisting of jojoba oil, almond oil, cocoa butter, bees wax, and sweet almond oil,wherein the tetraethyl orthosilicate is present in a concentration from 25% to 40% by total weight of the composition, and wherein the composition is presented as a cream or an ointment.