US Pat. No. 10,113,362

OFFSET SHAFT BEARING ASSEMBLY

TURBO DRILL INDUSTRIES, I...

1. An offset shaft bearing assembly for a downhole tool comprising:an outer housing, the outer housing having a housing centerline;
a drive shaft, the drive shaft extending through the outer housing, the drive shaft being generally tubular and having a shaft centerline; and
two or more radiused conical bearings positioned to couple the drive shaft to the outer housing, each radiused conical bearing having:
an outer surface, the outer surface being generally cylindrical, the outer surface coupled to the outer housing and aligned with the housing centerline;
an inner surface, the inner surface being generally cylindrical, the inner surface coupled to the drive shaft and aligned with the shaft centerline;
a first bearing surface, the first bearing surface coupled to the outer surface of the bearing; and
a second bearing surface, the second bearing surface coupled to the inner surface of the bearing, the bearing surfaces radiused such that the bearing surfaces remain in contact despite angular misalignment between the outer surface and the inner surface;
wherein at least one radiused conical bearing is offset from the housing centerline in a direction perpendicular to the housing centerline such that the shaft centerline is at an angle to the housing centerline.

US Pat. No. 10,113,359

STEADY-STATE GEAR STRUCTURE FOR ROLLER SHADE

My Home Global Company, ...

1. A gear structure comprising:at least one return wheel unit (1); and
a power transmission unit (2) connected with the at least one return wheel unit;
wherein:
the at least one return wheel unit includes a housing (11), a first wheel (12) mounted in the housing, a second wheel (13) mounted in the housing, and a spring (14) wound around the first wheel and having a distal end (141) secured to the second wheel;
the housing has an interior defining a receiving space (110) which has a bottom provided with two fitting portions (111);
the housing has a first side provided with a first passage (113) and a second side provided with a second passage (112);
the first wheel has a center provided with a first shaft (121) rotatably mounted on one of the two fitting portions and has a periphery provided with a first annular groove (122);
the first wheel is provided with a first gear (123) protruding outward from the first passage of the housing;
the second wheel has a center provided with a second shaft (131) rotatably mounted on the other one of the two fitting portions and has a periphery provided with a second annular groove (132);
the second wheel is provided with a second gear (133) protruding outward from the second passage of the housing;
the spring is wound around the first annular groove of the first wheel;
the distal end of the spring is secured to the second annular groove of the second wheel;
the power transmission unit includes a side bracket (21) juxtaposed to the housing of the at least one return wheel unit, a first driven gear set (22) mounted in the side bracket, a second driven gear set (23) mounted in the side bracket, a driving member (25) mounted on the side bracket, and a transmission member (24) connected between the driving member and the second driven gear set;
the side bracket has an interior defining a receiving chamber (210) which has a bottom provided with a first mounting portion (213) and has a side provided with a second mounting portion (214);
the side bracket has a surface provided with an opening (211);
the side bracket is provided with an extension (212);
the first driven gear set has a center provided with a first spindle (221) rotatably mounted on the first mounting portion of the side bracket;
the first driven gear set includes a third gear (222) and a first bevel gear (223) connected with the third gear;
the third gear of the first driven gear set meshes with the second gear of the second wheel;
the second driven gear set has a center provided with a second spindle (231) rotatably mounted on the second mounting portion of the side bracket;
the second driven gear set includes an engaging portion (233) and a second bevel gear (232) connected with the engaging portion;
the second bevel gear of the second driven gear set meshes with the first bevel gear of the first driven gear set;
the driving member is rotatably mounted on the extension of the side bracket;
the driving member has a first end provided with a driving portion (251) engaging the transmission member and a second end provided with a connecting portion (252);
the transmission member is mounted on the extension of the side bracket and extends through the opening of the side bracket; and
the transmission member engages the engaging portion of the second driven gear set.

US Pat. No. 10,113,358

WINDOW BLINDS WITH EXTENDABLE EDGES

Ristal, Inc., Tempe, AZ ...

1. A window shade comprising:a top rail;
a shade body extending down from the top rail and comprised of a plurality of collapsible tubular cells stacked to form a vertical shade, each of the tubular cells having at least one open distal end;
an insert comprised of a second plurality of collapsible cells and separable from the shade body, the second plurality of collapsible cells freestanding at one end and comprising connections at a distal end between adjacent cells of the second plurality of collapsible cells, each of the second plurality of collapsible cells configured to extend into a respective one of the plurality of collapsible tubular cells, wherein the insert extends a distance beyond the distal end of the shade body to increase an effective width of the window shade, and wherein the second plurality of collapsible cells is configured to be moved independently of and in unison relative to the shade body to vary the distance.

US Pat. No. 10,113,356

INSERTS FOR HOLLOW STRUCTURAL MEMBERS

Arconic Inc., Pittsburgh...

1. A structure for a building envelope dividing an exterior environment from an interior environment, comprising:a composite member having a pair of metal extrusions having a first thermal conductivity, the pair of extrusions connected by a thermal break formed from a material having a lower thermal conductivity than the metal extrusions, a first of the pair of extrusions being an exterior extrusion and a second of the pair being an interior extrusion, the composite member having a portion with an open, C-shaped cross-sectional shape, the hollow of the C-shaped cross-sectional shape communicating with a space exterior to the composite member, the hollow supporting heat transfer by convection between the pair of metal extrusions;
a monolithic insert formed independently of the composite member having stable free-standing dimensions, the insert inserting into the hollow and extending at least partially across the hollow, the insert being made from a material with a thermal conductivity less than the thermal conductivity of the metal extrusions and having a cross-sectional shape which at least partially subdivides the hollow into a plurality of sub-areas, the insert having an open U-shaped cross-sectional shape with a first wall extending at least partially across the open C-shape, the first wall defining the bottom of the U-shape and joining to a first side wall at one end and to a second side wall at another end, the first side wall and the second sidewall defining the side walls of the U-shape, the insert reducing the Nusselt number of the composite member relative to the Nusselt number of the composite member without the insert present in the hollow.

US Pat. No. 10,113,355

SOUNDPROOF DOOR FOR USE IN REDUCTION OF SOUND TRANSMITTED FROM ONE SIDE OF THE DOOR TO THE OTHER SIDE

NAN YA PLASTICS CORPORATI...

9. A soundproof door assembly for use in reduction of sound transmitted from one side of the door to the other side, having an STC number greater than of STC 30 determined in accordance with ASTM E413-10 and E90-09, comprising a soundproof door having a thickness of 30-70 mm, which comprisingtwo door skins, one formed as a front door skin and the other formed as a rear door skin for the soundproof door respectively;
a quadrilateral frame, constituted by a top rail member, a bottom rail member, a left stile member and a right stile member to seal the perimeter of the door skins; one or more reinforced members in parallel set up alongside one or more inner sides of the quadrilateral frame; and
a multiple-layered core to form a concrete inner portion of the door, which comprising; two spaced hard-soundproofing cores, to block sound with high frequency over 500 Hz, each formed as a single-layered soundproofing core having a thickness of 3-12 mm and made of calcium silicate board, silicon magnesium board, glass fiber composite board or ceramic composite board; and
a soft-soundproofing core, to block sound with high frequency beneath 500 Hz, interleaved in between the spaced hard-soundproofing cores to constitute with a sandwich structure, and the soft-soundproofing core is made of rock wool fiber board, glass fiber board, closed cell polyurethane foaming board, opened cell polyurethane foaming board, expandable polystyrene foaming board or expandable polyethylene foaming board;
a reinforced member positioned adjacent and extending parallel to a side of the soft-soundproofing core, and disposed and extending between the hard-soundproofing cores;
a doorframe, being a stationary quadrilateral door frame positioned proximately the soundproof door to support the soundproof door; and
one or more door hinges used to control the soundproof door capably to swing relative to the doorframe; and
a loop of soft packing strip, mounted on the quadrilateral door frame of the doorframe to tightly contact onto the door skin of the soundproof door if closed;
wherein the quadrilateral door frame of the doorframe is made from hard polyvinyl chloride (PVC) board, foamed PVC board, PVC composite extrusion board.

US Pat. No. 10,113,354

MULTIPLE-PANE INSULATING GLAZING UNIT ASSEMBLY, GAS FILLING, AND PRESSING MACHINE

Cardinal IG Company, Ede...

1. A system for producing multiple-pane insulating glazing units, the system comprising: a conveyor and a machine that assembles two or more glazing panes and one or more glazing spacers into a multiple-pane insulating glazing unit, the conveyor comprising a longitudinally extending conveyor line configured to transport the two or more glazing panes to the machine, the machine comprising a plurality of laterally spaced-apart processing stations, each processing station being movable transversely, along a transverse axis, relative to the longitudinally extending conveyor line to provide one of the plurality of laterally spaced-apart processing stations that is aligned with the longitudinally extending conveyor line while at least one other of the plurality of laterally spaced-apart processing stations is out of alignment with the longitudinally extending conveyor line, said at least one other of the plurality of laterally spaced-apart processing stations when out of alignment with the longitudinally extending conveyor line being operable to process the two or more glazing panes and one or more glazing spacers therein to fabricate the multiple-pane insulating glazing unit, wherein each of the plurality of laterally spaced apart processing stations comprises a processing zone located between two platens, wherein each processing zone is configured to receive the two or more glazing panes and one or more glazing spacers.

US Pat. No. 10,113,352

SYSTEM AND METHOD FOR OPERATING A DOCKING STATION

Rite-Hite Holding Corpora...

1. A dock control system comprising:a camera for mounting on a docking station, the camera configured to obtain at least one image of a vehicle restraint system of the docking station;
a graphical user interface configured to display the at least one image of the vehicle restraint system to an operator of the docking station to verify if a vehicle has been restrained; and
a controller configured to:
automatically activate the camera once the vehicle restraint system is engaged with a vehicle;
receive the at least one image of the vehicle restraint system from the camera; and
transmit the at least one image of the vehicle restraint system to the graphical user interface.

US Pat. No. 10,113,351

INTELLIGENT VEHICLE ACCESS POINT OPENING SYSTEM

FORD GLOBAL TECHNOLOGIES,...

1. A method, comprising:detecting a presence of an object in a vicinity of a cover of an access point of a vehicle and inside the vehicle;
receiving a command to open the cover;
activating a mechanism to open the cover responsive to receiving the command;
determining whether the object is likely to fall after the cover has been at least partially opened by:
measuring a relative distance between the object and a sensor on the cover as the cover is being opened; and
determining, based on the relative distance, whether the object is stationary and whether the object is non-stationary and moving toward the cover as the cover is being opened; and
pausing opening of the cover responsive to a determination that the object is likely to fall based on determining that the object is non-stationary and the object is moving toward the cover as the cover was being opened.

US Pat. No. 10,113,348

MAGNETIC LEVITATING DOOR

1. A door assembly with a door disposable in front of a door opening and traversable between an open position and closed position, the door assembly comprising:the door being slidable to the open and closed positions, the door defining a length;
two brackets attached to the door, the two brackets being positioned equidistantly on opposed sides of a vertical plane which intersects a center of gravity of the door;
a first magnet attached to each of the first and second brackets, the first magnet having a length less than the length of the door;
a track disposed adjacent to the door opening, the track defining a length about two times the length of the door, the first and second brackets being slidably mounted to the track, the track having opposed inwardly directed fingers;
a second magnet attached to the track, the second magnet having a length greater than a length of the door, the first and second magnets vertically aligned to each other and disposed vertically above stabilizing rollers;
the stabilizing rollers attached to the first and second brackets and disposed within the track, the stabilizing rollers having upper and lower ridges which collectively form grooves that receive the inwardly directed fingers in the grooves for maintaining a vertical position of the door and a vertical gap between the first and second magnets as the door is traversed between the open and closed positions, wherein each stabilizing roller extends horizontally and an axis of rotation of each stabilizing roller extends vertically through the first magnet.

US Pat. No. 10,113,345

COVER OF INSPECTION CHAMBER

ROMBA DRYWALL CZ S.R.O., ...

1. A cover system for an inspection chamber, the system comprising:a door comprising a magnetically conductive material;
a fixture that comprises at least one of an “L” shaped and a “U” shaped object, the at least one of the “L” shaped object and the “U” shaped object each comprising a front arm; and
a magnet that is coupled to and disposed on the front arm,
wherein the fixture is configured to couple to a wall at an opening in the wall,
wherein a perimeter of the door is at least partially defined by a welt, which extends from a portion of the door by a distance that is substantially equal to a sum of a height of the front arm and the magnet, and
wherein the magnet on the front arm is configured to magnetically couple to, and to selectively decouple from, the door in a plurality of different locations disposed within the perimeter defined by the welt.

US Pat. No. 10,113,344

STAY

Sugatsune Kogyo Co., Ltd....

1. A stay comprising:a first member;
a second member connected to the first member so as to be capable of rotating around a rotation axis in two opposing directions relatively;
a disk joined to the first member through a friction plate; and
a cam base capable of rotating around the rotation axis in an integrated manner with the second member, and capable of moving in a direction of the rotation axis through relative rotation of the second member with respect to the first member;
one of the second member and the cam base further comprising a convex part protruding to the other of the second member and the cam base; and
the other of the second member and the cam base further comprising a concave part which fits with the convex part;
wherein, when the second member rotates relative to the first member in one direction, the convex part fits with the concave part deeper, the cam base moves away from the disk in the direction of the rotation axis, and the second member and the cam base rotate relative to the first member and the disk; and
when the second member rotates relatively to the first member in the other direction, an inclined surface of the convex part and an inclined surface of the concave part come into contact, the cam base moves towards the disk in the direction of the rotation axis, and the second member, the cam base and the disk rotate relative to the first member with resistance force.

US Pat. No. 10,113,343

THERMALLY ISOLATED HIGH INTENSITY LIGHT SOURCE

Surna Inc., Boulder, CO ...

1. A high intensity discharge light source comprising:a bulb having:
a first end;
a second end;
a central region extending between said first end and said second end in a longitudinal direction; and
an outer surface extending between said first end and said second end;
a thermally insulative and optically transparent sleeve having an inner surface, said sleeve longitudinally aligned with and separated from said bulb outer surface by an insulating distance;
a first spacer positioned adjacent to said bulb first end and between said bulb outer surface and said sleeve inner surface;
a second spacer positioned adjacent to said bulb second end and between said bulb outer surface and said sleeve inner surface; wherein:
said first spacer and said second spacer provides said insulating distance between said bulb outer surface and said sleeve inner surface, thereby forming an insulative volume around said bulb; and
during use said bulb and surrounding insulative volume reach an elevated steady state operating temperature to maintain or enhance a spectral performance parameter.

US Pat. No. 10,113,338

MOTOR VEHICLE DOOR LOCK STATUS SYSTEM AND RELATED METHOD

Ford Global Technologies,...

1. A method of monitoring door lock status of a motor vehicle, comprising:monitoring, by controller, the door lock status of multiple doors of said motor vehicle; and
indicating, by indicator carried on a driver's door of said motor vehicle, the door lock status of said multiple doors of said motor vehicle.

US Pat. No. 10,113,337

LOCKSET

SINOX CO., LTD, New Taip...

1. A lockset, comprising:a first body, including:
a lock body disposed in the first body, wherein the lock body includes a combination lock;
a first upper face having a lock hole; and
a first side face having a positioning hole, wherein there is a first angle between the first upper face and the first side face; and
a second body, including:
a second upper face, wherein the first upper face and the second upper face both face the same direction, wherein a rotatable buckle having a rotating unit and a lock unit is disposed on the second upper face, wherein one end of the rotating unit is pivotally connected with the second upper face and the side of the other end of the rotating unit facing the second upper face is connected with the lock unit; and
a second side face facing the first side face, wherein a positioning unit is disposed in a position on the second side face corresponding to the positioning hole, wherein there is a second angle between the second upper face and the second side face;
when the first side face is in a lock position adjacent to the second side face, the positioning unit inserts into the positioning hole, and the rotatable unit is rotated to insert the lock unit into the lock hole, wherein the lock body restricts the lock unit from leaving the lock hole.

US Pat. No. 10,113,335

LATCH APPARATUS WITH INDEPENDENT IDENTICAL OPPOSING LATCHES

Carlson Pet Products, Inc...

1. A latch apparatus between a first object and a second object, the latch apparatus having a length direction, a width direction and a height direction, the latch apparatus comprising:a) a first keeper, the first keeper engaged to the first object, the first keeper extending in the length direction from the first object toward the second object;
b) a second keeper, the second keeper engaged to the second object;
c) the first keeper comprising a first under slide face portion, the first under slide face portion having a first proximal under slide end and a first distal under slide end, the first under slide face portion defining a first under slide direction;
d) the first keeper comprising a second under slide face portion, the second under slide face portion having a second proximal under slide end and a second distal under slide end, the second under slide face portion defining a second under slide direction;
e) a swinging piece having a distal end, the swinging piece pivotally engaged to the first object, the distal end of the swinging piece releasably engaged to the second keeper of the second object to permit the first object to be opened relative to the second object, the swinging piece having an open position where the swinging piece is disengaged from said second keeper of the second object, the swinging piece having a closed position where the distal end of the swinging piece is engaged to said second keeper of the second object;
f) the swinging piece comprising a first slot, the first slot having a first proximal slot end and a first distal slot end, the first proximal slot end being adjacent to the first proximal under slide end when the swinging piece is in the closed position, the first distal slot end being adjacent to the first distal under slide end when the swinging piece is in the closed position;
g) the swinging piece comprising a second slot, the second slot having a second proximal slot end and a second distal slot end, the second proximal slot end being adjacent to the second proximal under slide end when the swinging piece is in the closed position, the second distal slot end being adjacent to the second distal under slide end when the swinging piece is in the closed position;
h) the swinging piece comprising a first slider, the first slider engaged in the first slot, the first slider slidingly engaging the first under slide face portion from below the first under slide face portion, the first slider preventing the swinging piece from pivoting when the first slider is engaged with the first under slide face portion, the first slider being slideable beyond the first under distal slide end to permit the swinging piece to pivot and disengage from the second object; and
i) the swinging piece comprising a second slider, the second slider engaged in the second slot, the second slider slidingly engaging the second under slide face portion from below the second under slide face portion, the second slider preventing the swinging piece from pivoting when the second slider is engaged with the second under slide face portion, the second slider being slideable beyond the second distal under slide end to permit the swinging piece to pivot and disengage from the second object;
j) such that the swinging piece is locked in the closed position until each of the first and second sliders has been slid beyond the first and second distal under slide ends, whereupon the swinging piece may be swung to the open position.

US Pat. No. 10,113,334

ELECTRIC STRIKE LOCK

1. An electric strike lock, comprising:a strike body engaged with a cover plate;
a latch having a latch bolt and a deadlatch, said latch engaging a spring and being rotatably disposed inside the strike body together with said spring;
a keeper having a screw hole and a stop block displaceably disposed within the keeper, the stop block being connected to a solenoid which has a movable rod passing through the keeper and engaging the stop block, the stop block being displaced by the solenoid to move between a first position aligned with the deadlatch to block rotation of the latch and a second position unaligned with the deadlatch to allow rotation of the latch; and
an adjusting section including an elliptical adjusting hole formed through the cover plate in correspondence to the screw hole of the keeper, and an elliptical adjusting piece shaped in correspondence to the elliptical adjusting hole, said elliptical adjusting piece having an eccentrically-positioned through hole and an adjusting screw passing therethrough and to threadedly engage the screw hole of the keeper, a major axis of said elliptical adjusting hole extending in correspondence with an operating axis of the solenoid;
the elliptical adjusting piece being inserted into the elliptical adjusting hole in one of two orientations to locate the eccentrically-positioned through hole in a selected one of two locations for correspondingly locating the keeper relative to the solenoid and therewith disposing the stop block initially in either the first position or the second position and thereby set the electric strike lock as being fail-safe or fail-secure.

US Pat. No. 10,113,333

BOLT TO PIN WITH INTERCHANGEABLE COMBINATION

1. A bolt lock consisting of:a housing having:
a base end;
a shaft crossing through the housing, the shaft has a pin on an edge of the shaft, the pin including sections with ridges and sections without ridges;
a top end;
a plurality of cuts located on the top end;
a plurality of dividing walls inside the housing, the main shaft crossed through the dividing walls;
an external roller placed on each one of the cuts, the external rollers are separated by the dividing walls, the external rollers including an internal face and an external face having a plurality of segments separated by slots;
an internal roller placed inside each one of the external rollers, each one of the internal rollers having an internal face, an external face having a faceted edge, a borehole including a groove, the main shaft crossing through each one of the external rollers and the internal rollers;
a support placed on an extension of the base end of the housing, the support has a pivoting movement with a locking device located outside the housing;
a strap located at each one of the slots, the straps are fixed into a strap base anchored to the housing;
wherein when the edge pin of the main shaft coincides with groove of the internal roller, the main shaft slips and unlocks the bolt lock; and
wherein when the edge pin of the main shaft does not coincide with groove of the internal roller, the bolt lock is locked.

US Pat. No. 10,113,332

METHOD FOR INSTALLING DOOR LOCKS

PUNCH POINT TOOLS, L.L.C....

1. A method of installing a latch or bolt plate on a door frame having a door attached to the frame with an extendable and retractable deadbolt with a deadbolt cross sectional shape, comprising the steps of:(a) providing a marking apparatus, the marking apparatus including a marking apparatus shape;
(b) placing the marking apparatus on the latch or deadbolt and aligning the marking apparatus shape with the latch or deadbolt cross sectional shape;
(c) while the marking apparatus is on the latch or deadbolt, closing the door in the door frame;
(d) while the door is closed, causing the latch or deadbolt to extend causing the marking apparatus to be transposed from attachment to the latch or deadbolt to attachment to the door frame;
(e) opening the door and exposing the marking apparatus now attached to the door frame at a location;
(f) using the location of the transposed marking apparatus on the door frame to install a plate on the door frame for receiving the latch or dead bolt.

US Pat. No. 10,113,329

EAVE STRUCTURE AND TENT FRAME HAVING SAME

Campvalley (Xiamen) Co., ...

1. An eave structure of a tent frame, wherein the tent frame comprises a supporting pole, a first upper pole, and a second upper pole, the eave structure comprising:a sleeve member configured to be disposed at a first connector of the tent frame;
an eave pole slidably coupled with the sleeve member;
a connecting pole having a first end portion pivotally connected with a first end portion of the eave pole and a second end portion pivotally connected with a sliding connector; and
the sliding connector slidably coupled with the first upper pole and movable along the first upper pole,
wherein:
the first connector is fixedly coupled with an upper end portion of the supporting pole,
a first end portion of the first upper pole is pivotally connected with a hub of the tent frame,
a second end portion of the first upper pole is pivotally connected with a first end portion of the second upper pole, and
a second end portion of the second upper pole is pivotally connected with the first connector.

US Pat. No. 10,113,328

CANOPY ASSEMBLY FOR PROVIDING PRIVACY

1. A canopy assembly structured to provide privacy adjacent to a vehicle, said canopy assembly comprising:a support assembly,
a screen connected to at least a portion of said support assembly,
an attachment assembly comprising at least one attachment structure connected to a portion of said support assembly, said at least one attachment structures disposed and structured to support said screen in an operative orientation,
at least two openings disposed on said screen each extending substantially along a height of said screen,
said screen and said support assembly collectively disposable into an expanded orientation and a collapsed orientation,
each of said at least two openings configured and dimensioned to allow passage therethorugh of an individual, when in said expanded orientation,
said operative orientation comprising said screen disposed in said expanded orientation and in depending relation from said support assembly, adjacent an interior of a vehicle door, concurrent to one of said at least two openings disposed in direct communication with a vehicle interior, and
said expanded orientation further comprising a privacy enclosure at least partially defined by said screen having a closed configuration.

US Pat. No. 10,113,326

MODULAR HEAT EXCHANGE TOWER AND METHOD OF ASSEMBLING SAME

SPX Cooling Technologies,...

1. A modular heat exchange tower that extends vertically along a longitudinal axis, comprising:a first module comprising a first basin disposed therein;
a second module comprising a second basin disposed therein;
a plenum;
a first heat exchange section;
an air current generator having at least one blade;
a second heat exchange section;
a third module; and
a fourth module,
wherein the first heat exchange section is disposed in the first module and the third module,
wherein the second heat exchange section is disposed in the second module and the fourth module,
wherein the third module is positioned vertically adjacent to the first module along the longitudinal axis,
wherein the fourth module is positioned vertically adjacent to the second module along the longitudinal axis,
wherein the first heat exchange section disposed in the first module and the third module is further disposed vertically adjacent to the first basin along the longitudinal axis,
wherein the second heat exchange section disposed in the second module and the fourth module is further disposed vertically adjacent to the second basin along the longitudinal axis; and
a fifth module, wherein the fifth module comprises at least a portion of the air current generator and wherein said at least one blade extends from said fifth module into said first module.

US Pat. No. 10,113,323

CONCRETE FORMING STAKE APPARATUS

Stego Industries, LLC, S...

1. A concrete forming stake apparatus, comprising:a base member having a planar side and a stake mounting port disposed opposite the planar side;
a stake attachment unit including:
a tubular portion that engages with the stake mounting port, and
a joint connected to the tubular portion;
a stake that attaches to the joint; and
an adhesive layer disposed against the planar side of the base member, the adhesive being configured to secure the apparatus to a surface without penetrating fasteners.

US Pat. No. 10,113,322

VERTICALLY LAPPED FIBROUS FLOORING

Zephyros, Inc., Romeo, M...

1. A flooring assembly comprising:a) at least one thermoformable short fiber nonwoven material layer;
b) at least one pressure sensitive adhesive layer including a flexible substrate, a mesh and an adhesive located along the flexible substrate; and
c) at least one moisture impermeable membrane layer.

US Pat. No. 10,113,321

DECKING SUPPORT SYSTEM

1. A decking support system including:a plurality of decking support elements, each decking support element including a first decking support engagement feature and a second decking support engagement feature,
a plurality of connection elements, wherein at least one of the plurality of connection elements includes a first side including a first connection element engagement structure and a second side including a second connection element engagement structure, wherein the first connection element engagement structure includes a first connection feature adapted to co-operate with said first decking support engagement feature of a decking support element, and a second connection feature adapted to co-operate with said second decking support engagement feature of a decking support element, wherein the first connection feature includes at least one wall extending outwardly and away from said first side, and a groove positioned in said at least one wall; and
wherein a first of said plurality of decking support elements is adapted to be engaged with a second of said plurality of decking support elements by the at least one of said plurality of connection elements.

US Pat. No. 10,113,320

RESTRAINT SYSTEM FOR ELEVATED FLOORING TILES

United Construction Produ...

1. An elevated flooring surface assembly, comprising:a plurality of support apparatuses spacedly disposed upon a fixed surface;
a plurality of flooring units disposed over upper surfaces of the support apparatuses to create an elevated flooring surface, wherein each flooring unit includes:
a support plate including:
a base having a top surface, a bottom surface opposite to the top surface, a plurality of corner portions, a plurality of outer edge segments disposed between adjacent corner portions, and an outer periphery formed by the plurality of outer edge segments and the plurality of corner portions, wherein the top surface resides in a first reference plane; and
at least a first attachment member interconnected to the base adjacent a first of the outer edge segments, wherein the first attachment member is disposed outside of the outer periphery of the base, wherein the first attachment member includes a top surface and a bottom surface opposite to the top surface, and wherein the top surface of the first attachment member is disposed between the first reference plane and the bottom surface of the first attachment member; and
a building surface component positioned over the support plate, wherein the building surface component includes a top surface, a bottom surface opposite to the top surface, a plurality of corner portions, and a plurality of outer edge segments disposed between adjacent corner portions, wherein the bottom surface of the building surface component is disposed over the top surface of the base of the support plate; and
a plurality of restraint apparatuses, wherein each restraint apparatus includes a base having a top surface and a bottom surface opposite to the top surface, wherein each restraint apparatus includes a spacer member extending upwardly away from the top surface of the restraining apparatus base, wherein the base of each restraint member is disposed over the top surfaces of the first attachment members of at least first and second of the flooring units and secured to the upper surface of at least one of the support apparatuses, and wherein the spacer of each of restraint member spaces the first and second flooring units from each other.

US Pat. No. 10,113,319

MECHANICAL LOCKING SYSTEM FOR PANELS AND METHOD OF INSTALLING SAME

VALINGE INNOVATION AB, V...

1. A set comprising a first panel and second panel, wherein the first and second panel are mechanically connectable to each other along at least one pair of adjacent edges, said panels each being provided with a tongue and groove formed in one piece with the panels, wherein the tongue and groove are configured to cooperate for mechanically locking together said adjacent edges at right angles to the principal plane of the panels, thereby forming a mechanical connection between the panels, said panels being provided with a first locking element at one first edge formed in one piece with the panel and a locking groove at an opposite second edge, the locking groove being open towards a rear side or a front side of the panel,each panel being provided with a second locking element, formed of a separate material and connected to the locking groove,
the first and second locking elements are configured to cooperate for locking the panels to each other in a direction parallel to the principal plane and at right angles to the joint edges,
the second locking element has a groove portion located in the locking groove and a projecting portion located outside the locking groove,
the second locking element is flexible and resilient such that the panels, are configured to be mechanically joined by displacement of the panels towards each other, wherein the projecting portion is configured to pivot towards the groove portion when the panels are displaced until said adjacent edges of the panels are brought into engagement with each other at the joint plane, and the second locking element at said second edge is displaced towards its initial position against the first locking element at the first edge.

US Pat. No. 10,113,317

APPARATUS AND METHOD FOR HANGING ARCHITECTURAL PANELS WITH CONCEALED ATTACHMENT POINTS

Gordon Sales, Inc., Boss...

9. A panel anchoring system comprising:a) a latching assembly comprising:
i) a base bracket, the base bracket comprising first and second projecting walls; and
ii) a resilient beam movably coupled to the base bracket so as to allow the resilient beam to deflect, wherein the resilient beam is a sinusoidal-shaped wire spring comprising a first leg and a second leg, wherein the first leg of the sinusoidal-shaped wire spring is movably coupled to a first elongated hole in the first projecting wall, and wherein the second leg of the sinusoidal-shaped wire spring is movably coupled to a first elongated hole in the second projecting wall; and
b) a panel comprising a keyed flange, the keyed flange comprising:
i) first and second locking slots configured for releasable attachment to the first and second legs of the sinusoidal-shaped wire spring; and
ii) first and second ramps, with the first ramp being positioned adjacent to the first locking slot, and with the second ramp being positioned adjacent to a second locking slot.

US Pat. No. 10,113,316

POST MOUNT CABLE RAIL INSTALLATION SYSTEM

Vinylast, Inc., Lakewood...

1. A post mount system, comprising:a mounting pipe, wherein the mounting pipe comprises a first plurality of holes, each hole of the first plurality of holes including a plurality of threads to secure a hardware item that attaches to an end of a cable rail;
a support pipe for fitting over the mounting pipe, wherein the support pipe comprises a first end, a second end, and a second plurality of holes that are aligned with the first plurality of holes of the mounting pipe;
a post for fitting snugly over the support pipe;
the hardware item, wherein the hardware item includes a threaded portion, wherein the threaded portion is for attaching the hardware item to the mounting pipe by engaging the plurality of threads of a first hole of the first plurality of holes, and wherein the hardware item comprises an anchor for the cable rail; and
the cable rail, wherein the cable rail comprises a cable that is sized for passing substantially unhindered through the second plurality of holes of the support pipe.

US Pat. No. 10,113,314

LIQUID RELEASE AGENT AND ASSOCIATED METHODS OF APPLICATION

TAMKO Building Products, ...

1. An asphalt shingle comprising:a substrate sheet having a top surface and a bottom surface, the substrate sheet being coated with asphalt on at least one of the top surface or the bottom surface;
a first dispersed solid release layer on the bottom surface resulting from the dispersion and evaporation of a first liquid release layer, wherein said first liquid release layer is applied to the bottom surface;
a second dispersed solid release layer on the bottom surface resulting from the dispersion and evaporation of a second liquid release layer applied to said bottom surface, wherein the first dispersed release area only partially covers the bottom surface at the time the second dispersed release layer is applied.

US Pat. No. 10,113,313

SHEATHING RETENTION CAPSULE

1. A method of coupling a tension member to an anchor to form a post-tensioning tendon comprising:a) providing a tension member comprising a strand and a sheath, the sheath positioned about the strand;
b) providing an anchor, the anchor including:
a sheathing retention capsule having a tapered inner surface defining a forcing surface; and
one or more holding wedges, at least one of the one or more holding wedges having an inner wall and a tapered outer surface, the tapered outer surface abutting the forcing surface;
c) removing a portion of the sheath from a first end of the tension member;
d) inserting the first end of the tension member into the anchor,
e) inserting the sheath into the one or more holding wedges,
f) forming a press-fit between the sheath and the inner wall of the one or more holding wedges; and
g) coupling the strand to the anchor,
wherein step f) comprises applying a tensile force to the sheath and tightening the press-fit between the generally cylindrical sheath and the one or more holding wedges.

US Pat. No. 10,113,310

COATING MATERIAL FOR ACHIEVING SOUND-DAMPENING AND METHOD FOR THE SAME

Blue Angel Paint and Coat...

1. A sound-dampening coating material comprising:a base coat material having an applied thickness in the range of from about 25 to about 30 mil, the base coat material having the following formula:
20 to 40 percent by weight of a rubber emulsion; about 10 to about 20 percent by weight of a carbonate filler; about 3 to about 10 percent by weight of a fire retardant; about 3 to about 10 percent by weight of an opacity filler; and
about 10 to about 64 percent by weight of other components for affecting characteristics of the base coat material;
a top coat material applied over the base coat material to a thickness in the range of from about 7 to about 10 mil, the top coat material having the following formula:
about 40 to about 80 percent by weight of a rubber emulsion; about 10 to about 20 percent by weight of a carbonate filler; about 3 to about 10 percent by weight of a fire retardant; about 3 to about 10 percent by weight of a opacity filler; and
about 0 to about 44 percent by weight of other components for affecting characteristics of the top coat material.

US Pat. No. 10,113,309

FLOOD VENT BARRIER SYSTEMS

Smart Vent Products, Inc....

1. A vent barrier system comprising:an insert comprising side faces extending between a first end and a second end of the insert, wherein the insert is dimensioned to be inserted within a flood vent duct through a first opening such that the side faces contact sidewalls of the duct and provide an insulative seal between the first opening and a second opening of the duct when inserted therein;
a cover having a first side and a second side configured to be attached to the first face of the insert, wherein the cover is dimensioned to be selectively securable to the duct at the first opening, wherein the cover is manipulatable to selectively remove the insert from the duct; and
a door positioned at the second opening of the duct;
wherein the insert is dimensioned to extend within the duct and prevent the door positioned at the second opening of the duct from opening in a first direction when inserted therein, wherein the insert is dimensioned such that a second face is located adjacent to the door when inserted within the duct to prevent the door from moving from a closed position to an open position, wherein the door is configured to open in a second direction when the insert is inserted therein.

US Pat. No. 10,113,307

ROLLING BLOCK RESTRAINT CONNECTOR

1. A rolling block restraint connector for forming a moment resisting connection at a joint intersection between a continuous column and at least a first continuous beam that intersects the continuous column, the connector comprising:a first restraint assembly including (i) a first beam_pressure block, (ii) a first column pressure block, and (iii) a first tubular shaft that passes through tubular channels of the first beam_pressure block and the first column pressure block;
a second restraint assembly including (i) a second beam_pressure block, (ii) a second column pressure block, and (iii) a second tubular shaft that passes through tubular channels of the second beam_pressure block and the second column pressure block, wherein the second restraint assembly is configured to be located diagonally across the joint intersection from the first restraint assembly;
a first linkage that couples the first restraint assembly with the second restraint assembly, wherein the first linkage passes through a first end of the first tubular shaft and a first end of the second tubular shaft, wherein the first linkage is configured to be located on an exterior of the first continuous beam relative to the joint intersection; and
a second linkage that couples the first restraint assembly with the second restraint assembly, wherein the second linkage passes through a second end of the first tubular shaft and a second end of the second tubular shaft.

US Pat. No. 10,113,305

LOAD BEARING INTERLOCKING STRUCTURAL BLOCKS AND TENSIONING SYSTEM

JUST BIOFIBER STRUCTURAL ...

1. A structural panel assembled of structural blocks with a tensioning system for contributing to lateral load bearing attributes of the panel, comprising:a plurality of structural blocks, each structural block having opposed pin and aperture surfaces, opposed side surfaces and opposed end surfaces;
a plurality of load-bearing structural strut members embedded within each structural block, a pin end of each strut member extending from a pin surface of the structural block, wherein one or more of the embedded strut members comprises a lengthwise cavity therethrough;
a plurality of apertures extending within the structural block from the aperture surface opposite the pin surface of the structural block each of the apertures adapted for engaging with an extending pin end of a structural strut member of an adjacent structural block which then places an end of a structural strut member of the structural block adjacent to an end of a structural strut member of the adjacent structural block, each strut member extending a distance from a block's one surface and being positioned retracted by a like distance from the same blocks' opposite surface, the space from the retracted strut end to the block's surface being the aperture;
the stacked structural blocks causing the structural struts to also be stacked end-to-end through the panel formed by the stacked blocks, forming:
structural columns of structural strut members aligned to form compression load-bearing internal columns inside the panel;
conduits from one edge at a pin side of an outer block of the panel to the opposite edge of the panel at the aperture side of an aligned outer block of the panel to receive and accommodate tensioning means, the conduits comprised of lengthwise cavities within a column of stacked structural struts within the panel; and
tensioning means positioned within the lengthwise conduits formed of the cavities of one or more embedded end-to-end adjacent strut members, wherein the cavities in the embedded strut members of end-to-end adjacent structural blocks align to form the conduit for receiving the tensioning means, the tensioning means within the assembled panel under tension;
the structural struts aligned within each block in parallel pairs, one strut of each pair parallel to and nearer to one side of the block and the other strut of the same pair parallel to and nearer to the opposite side of the block;
the apertures and protruding pin ends on the aperture surface and the pin surface, respectively, arrayed to easily align blocks to be stacked, the pins and apertures providing block self-alignment guides for assembly of blocks to form the panel; and
the blocks within the panel further comprising a connecting web situated and embedded in the body of the structural blocks in between two strut members of a pair of strut members, the web being perpendicular to the longitudinal axis of the block and attached to both strut members of the pair of strut members.

US Pat. No. 10,113,304

SYSTEM AND METHOD FOR AGENT-BASED CONTROL OF SEWER INFRASTRUCTURE

EMNET, LLC, South Bend, ...

1. A control system to control fluid flow through a sewer system having a plurality of supplying assets, said control system comprising:a first supplying agent associated with a first supplying asset of said plurality of sewer supplying assets, wherein said first supplying agent assigns a first virtual cost to any fluid flow incoming to said first supplying asset, wherein said first virtual cost is based on a state of said first supplying asset;
a second supplying agent associated with a second supplying asset of said plurality of sewer supplying assets, wherein said second supplying agent assigns a second virtual cost to any fluid flow incoming to said second supplying asset, wherein said second virtual cost is based on a state of said second supplying asset;
a control agent associated with a control asset, wherein said control asset is adapted to direct said fluid flow from said control asset to said first supplying asset and/or said second supplying asset;
a computer network configured to accept said first virtual cost from said first supplying agent and said second virtual cost from said second supplying agent and to provide said first virtual cost and said second virtual cost to said control agent; and
wherein said control agent directs flow from the said control asset to said first supplying asset and/or said second supplying asset by minimizing a cost based on the said first virtual cost, said second virtual cost and a forecasted time delay of fluid flow from said control asset to one or both of said first supplying asset and said second supplying asset.

US Pat. No. 10,113,303

COVER ASSEMBLY FOR A FLOOR DRAIN

Drain Dome LLC, Roanoke,...

1. A cover assembly for a drain comprising:a saucer-shaped cover body having a first side for facing toward a drain opening in a surface having a drain pipe and a second side for facing away from the drain opening, the saucer-shaped cover body defining a plurality of flow passages extending between said first side and said second side so as to allow a liquid to pass through the cover body to the drain opening, at least a portion of the second side of the saucer-shaped cover body having a corrugated configuration formed by adjacent grooves and ridges, said grooves and ridges cooperating to facilitate reduction in blockage of said flow passages by debris on said second side of said saucer-shaped cover body; and
an anchor having a stem and deformable insert structure having a width diameter greater than the internal diameter of said drain pipe, said stem being removably attachable to said saucer-shaped cover body so as to depend from said first side thereof, and said insert structure including a pair of split fork loops at a distal end thereof sized to deform inwardly when inserted into the drain pipe and cause the insert structure to exert pressure on and frictionally engage the internal wall of the drain pipe.

US Pat. No. 10,113,302

TOOL RETENTION SYSTEM HAVING POCKETED WEDGE

Catepillar Inc., Deerfie...

1. A wedge for a tool retention system, comprising:a body having a tip end and an opposing base end that is wider than the tip end;
a channel formed in the body and extending from the base end to the tip end;
an elongated pocket formed in the body at the tip end that is open to the channel; and
a ramp located in the body and extending between the channel and an end of the elongated pocket, the ramp being inclined relative to an axis of the channel, wherein the ramp is located at the tip end of the body and protrudes inward from a channel inner surface toward the elongated pocket, and wherein the ramp is a first ramp; and the wedge further includes a second ramp located at a point between the base end of the body and the first ramp, the second ramp protruding outward from a curved surface of the channel toward the elongated pocket.

US Pat. No. 10,113,301

ARRANGEMENT FOR THE REMOVABLE COUPLING OF A TOOL WITH A MANOEUVRABLE ARM OF A WORKING MACHINE

BROKK AKTIEBOLAG, Skelle...

1. An arrangement for removing coupling of a tool with a working machine, the arrangement comprising:a first part that is supported by the tool and that comprises a first and a second indentations in essentially U-shaped located opposite to and at a distance from each other,
a second part that is supported by a maneuverable arm that is a component of the working machine and that comprises a first shaft and a second shaft that are introduced into the first and second indentations, respectively in the coupled condition of the arrangement,
a lever with which the first and the second shafts are coupled in such a manner that they are allowed to move towards and away from each other, and
a locking mechanism located between the first and the second shafts for the displacement thereof towards and away from each other, and for introduction of the first and the second shafts into the respective indentations,
wherein the first shaft is coupled with a rigid first arm section that is a component of the maneuverable arm, the second shaft is united at a joint with a second arm section of the maneuverable arm that is mobile relative to the first arm section, the lever comprises at least one pair of knee lever joints, each knee lever joint comprising a first lever and a second lever, the first lever and the corresponding second lever are coupled at their opposing ends with the first shaft and the second shaft respectively,
a central intermediate region of the first and the second shafts form bearing points that are jointed with the first and second arm sections of the maneuverable arm, while external elements of the first and the second shafts are located in the first and the second indentations, respectively in the coupled condition of the arrangement, and
the locking mechanism comprises one or several control and actuator means that can be activated through remote control and that operate between the first lever and the corresponding second lever for the displacement of the first and the second shafts from each other to have a tension-based interaction with the bottom of the respective indentations.

US Pat. No. 10,113,300

WORK VEHICLE AND RIPPER DEVICE

KOMATSU LTD., Tokyo (JP)...

1. A ripper device attached to a work vehicle, comprising:a first cylinder including a tube and a rod, the first cylinder being disposed to extend and retract in a forward and backward direction in a plan view of the ripper device;
a single shank disposed in alignment with the first cylinder in the forward and backward direction in the plan view such that, in the plan view, the first cylinder and the shank are disposed on a same line extending in the forward and backward direction; and
an arm supporting the shank, the arm overlapping the tube of the first cylinder in the plan view.

US Pat. No. 10,113,299

EXCAVATING APPARATUS AND EXCAVATING METHOD

KOBELCO CONSTRUCTION MACH...

1. An excavating apparatus for forming a continuous trench below a ground surface, comprising:an apparatus body disposed on the ground surface;
a support member suspended from the apparatus body and disposed below the ground surface;
an endless-shaped chain supported by the support member in such a manner as to be movable on an outer periphery of the support member along a given circulating movement plane in a given circulating movement direction;
a plurality of excavation blade plates fixed to an outer peripheral surface of the chain at intervals along the circulating movement direction of the chain, each of the excavation blade plates including: a plate body extending longer than the chain in a width direction of the chain orthogonal to each of the circulating movement plane of the chain and the circulating movement direction of the chain, and having an obverse surface and a reverse surface; and a plurality of excavation blades arranged on the obverse surface of the plate body at least at opposite ends thereof in the width direction, in opposed relation to a ground below the ground surface, the excavation blade plates being circulatingly movable integrally together with the chain to thereby excavate the ground;
a plurality of fastening members fastening the chain and the excavation blade plates together in a direction parallel to the circulating movement plane and orthogonal to the width direction, in such a manner that the outer peripheral surface of the chain and the reverse surface of the plate body come into press contact with each other;
a chain drive section which circulatingly moves the chain in the circulating movement direction; and
a support member drive section which moves the support member in a given forward movement direction,
wherein:
the support member has a pair of restraining surfaces disposed in spaced-apart relation to each other in the width direction and each continuously extending in the circulating movement direction; and
each of the excavation blade plates includes a pair of restraint members disposed on both sides of and across the chain in the width direction to extend from the reverse surface of the plate body, the pair of restraint members having, respectively, a pair of restraint-target surfaces each contactable with a corresponding one of the restraining surfaces of the support member at an arbitrary position in the circulating movement direction, in such a manner as to enable each of the excavation blade plates to be restrained from being rotated about an axis extending in the circulating movement direction.

US Pat. No. 10,113,298

REAR ATTACHMENT

1. A rear attachment device to connect an implement attachment to a rear of a vehicle comprised of a first plate assembly, a second plate assembly and an arm assembly;a front of the vehicle is adapted to temporarily connect to the implement attachment with full functionality of the implement attachment;
the implement attachment is any commercial attachment that is adapted to be full functioning when attached to a hydraulic power at a front of the vehicle;
the first plate assembly is affixed to a predetermined first surface at a rear of a vehicle;
the second plate assembly is affixed to a predetermined second surface at the rear of a vehicle;
the arm assembly on a first lower edge articulably attaches with a hinge to a lower edge of the first plate assembly;
the arm assembly on a second lower edge articulably attaches with a hinge to a lower edge of the second plate assembly;
a first hydraulic actuator is articulably affixed at a first end to an upper edge of the first plate assembly and on a second end is articulably affixed to a first upper edge of the arm assembly;
a second hydraulic actuator is articulably affixed at a first end to an upper edge of the second plate assembly and on a second end is articulably affixed to a second upper edge of the arm assembly;
a bracket on the arm assembly is adapted to removably connect to the implement attachment by maneuvering a hook on the implement attachment over a top edge of the arm assembly bracket and lifting the implement attachment without connecting a hydraulic power to the implement attachment;
the hook held over the arm assembly bracket supports a weight of the implement attachment;
when the first hydraulic actuator and the second hydraulic actuators are selectively simultaneously retracted, the relative angle between the arm assembly and the first and second plate assemblies decreases sufficiently to use or carry the implement attachment;
the arm assembly includes a lock to selectively secure the attachment to the bracket on the arm assembly;
wherein the implement attachment is located behind the vehicle when it is affixed to the rear attachment device.

US Pat. No. 10,113,296

DRAGLINE BUCKET RIGGING SYSTEM

Bright Technologies, L.L....

1. A dragline bucket assembly, comprising:(a) a bucket having a first lateral side and a second lateral side;
(b) a spreader bar having a first end and a second end;
(c) a first lower tensile member connecting said first lateral side of said bucket to said first end of said spreader bar;
(d) a second lower tensile member connecting said second lateral side of said bucket to said second end of said spreader bar;
(e) a yoke;
(f) a first upper tensile member connecting said first end of said spreader bar to said yoke;
(g) a second upper tensile member connecting said second end of said spreader bar to said yoke;
(h) wherein said first upper tensile member includes,
(i) a flexible stranded core, having a first end, a second end, and a stranded core outer diameter,
(ii) an armor layer, having a first end, a second end, an inner armor layer diameter, an outer armor layer diameter, and an armor layer cross sectional area,
(iii) wherein said armor layer inner diameter is substantially greater than said stranded core outer diameter,
(iv) wherein said armor layer cross sectional area is at least 25% of an area of a circle having a diameter equal to said outer armor layer diameter,
(v) a first anchor connected to said first end of said stranded core by a first potted region,
(vi) a second anchor connected to said second end of said stranded core by a second potted region,
(vii) wherein said first end of said armor layer is connected to said first anchor by a first armor layer connection that is separate from said first potted region, and
(viii) wherein said second end of said armor layer is connected to said second anchor by a second armor layer connection that is separate from said second potted region.

US Pat. No. 10,113,295

WORK MACHINE FOR DRAGLINE BUCKET OPERATION

Liebherr-Werk Nenzing Gmb...

1. A work machine for dragline bucket operation, comprising a dragline bucket taken up by a hoist rope, wherein the bucket is retractable by at least one dragline for carrying out a dragging movement and a dragline guide comprising a plurality of pulleys and roller bodies for guiding the dragline is arranged at the work machine,wherein the dragline guide is linearly movable in a horizontal direction, transverse to a dragline pulling direction,
wherein an electronic controller is provided for controlling one or more drive elements, with the electronic controller taking account of a deflection angle of the dragline on a dragline winch; and
wherein a roller head of the dragline guide comprising the plurality of pulleys and roller bodies is pivotable about a pivot angle of 360° relative to a tubular receiver.

US Pat. No. 10,113,293

BUCKET FOR CABLE SHOVEL

ESCO Group LLC, Portland...

1. A cable shovel bucket comprising a shell and a door collectively defining a cavity for gathering material during operation of the cable shovel, the shell including a front wall, an opposite back wall and sidewalls extending between the front wall and the back wall, the back wall having an exterior surface that faces the cable shovel when the bucket is in a dumping position, the door being pivotally secured to the shell for gravity activated movement between an open position and a closed position about a pivot axis extending through the cavity between the exterior surface of the back wall of the shell and the front wall and including a restraint to selectively hold the door in the closed position.

US Pat. No. 10,113,292

QUICK COUPLER CONTROL DEVICE FOR WORKING MACHINE

Caterpillar SARL, Geneva...

1. A quick coupler control device for a working machine comprising:a quick coupler that allows a work tool to be removably installed on a working arm of the working machine;
a lock cylinder attached to the quick coupler and having a lock-side chamber that is pressurized when the work tool installed on the quick coupler is actuated in a lock direction in which the work tool is fixed and an unlock-side chamber that is pressurized when the work tool is actuated in an unlock direction in which the work tool is unfixed;
a solenoid-operated first direction control valve having an unexcited position where a working fluid fed under pressure from a fluid pressure source is guided to a lock-side chamber of the lock cylinder and an excited position where the working fluid fed under pressure from the fluid pressure source is guided to an unlock-side chamber of the lock cylinder and where a return fluid discharged from the lock-side chamber is discharged to a low pressure side of the fluid pressure source;
a pilot-operated first check valve that sets a forward direction, in which a working fluid is fed under pressure from the first direction control valve to the lock-side chamber of the lock cylinder, a check function of the pilot-operated first check valve being cancelled by a working fluid fed under pressure to the unlock-side chamber of the lock cylinder;
a pilot-operated second check valve that sets a forward direction, in which a working fluid is fed under pressure to the unlock-side chamber of the lock cylinder, a check function of the pilot-operated second check valve being cancelled by a working fluid fed under pressure to the lock-side chamber of the lock cylinder;
a solenoid-operated second direction control valve having an unexcited position where a return fluid flowing out from the unlock-side chamber of the lock cylinder via the second check valve is discharged to the low pressure side of the fluid pressure source and where a working fluid fed via the first direction control valve is blocked and an excited position where a working fluid fed via the first direction control valve is guided to the unlock-side chamber of the lock cylinder;
a tool cylinder that pivots the work tool that is removably installed on the working arm of the working machine via the quick coupler;
a mode selector switch that switches between a lock mode where the lock cylinder is actuated in the lock direction and an unlock mode where the lock cylinder is actuated in the unlock direction;
a first sensor that detects whether a state of operation where the tool cylinder is actuated in a predetermined direction is established or whether a state of no operation where the tool cylinder is not actuated in the predetermined direction is established;
a second sensor that detects whether a loaded state where load is applied to the tool cylinder is established and a unloaded state where load is not applied to the tool cylinder is established; and
a controller having a function to control the first direction control valve and the second direction control valve to the unexcited position when the mode selector switch is in the lock mode and to control the first direction control valve and the second direction control valve to the excited position when the mode selector switch is in the unlock mode and the first sensor and the second sensor detect the operation state and the loaded state, respectively, and otherwise to control the first direction control valve and the second direction control valve to the excited position and the unexcited position, respectively.

US Pat. No. 10,113,290

METHOD OF INSTALLING A FOUNDATION IN THE SEA BED AND SUCH FOUNDATION

1. A sea bed foundation for an offshore facility, said sea bed foundation having a circumferential side wall substantially defining a cylinder, which cylinder is closed in one end and provided with an opening in the opposite end, thereby defining a primary chamber, said sea bed foundation is hollow, downwardly open and where said side wall defines a skirt, said primary chamber being connected to a primary pump, and wherein said sea bed foundation further comprises one or more secondary chambers, said secondary chambers being separate from the primary chamber, and being downwardly open, but otherwise closed by the sea bed foundation, where said one or more secondary chambers are connected to one or more secondary pumps wherein said primary pump is a suction pump and said secondary pump is a pressure pump, and where an over-pressure created by the one or more secondary pumps increases a resistance against penetration adjacent the one or more secondary chambers, allowing a rest of the foundation to penetrate a bottom at a normal resistance, thereby rectifying an orientation of the foundation.

US Pat. No. 10,113,289

FORMS AND SUBSURFACE STRUCTURAL ELEMENTS THAT REDIRECT SOIL FORCES

V-Forms, LLC, Cedar Park...

1. A form for constructing at least a portion of a structural foundation, the form comprising:one or more wall forming portions configured to shape a foundation material to form one or more respective walls of at least one subsurface structural element of the at least a portion of the structural foundation; and
one or more termination forming portions configured to shape the foundation material to form a corresponding termination portion of the at least one subsurface structural element such that the termination portion is adjacent to a bottom portion of at least one of the one or more respective walls, wherein the termination portion and the at least one wall meet at a non-zero angle greater than or less than 90 degrees,
wherein the termination portion is a lower most portion of the structural foundation; and
wherein the form is configured to shape, based at least in part on the one or more wall forming portions, the foundation material to form the at least one subsurface structural element such that:
the at least one subsurface structural element extends from a surface-level base of the structural foundation to a subsurface level; and
the at least one subsurface structural element is configured to redirect soil forces to vertically displace the structural foundation.

US Pat. No. 10,113,287

TWO-WIRE CONTROLLING AND MONITORING SYSTEM FOR IN PARTICULAR IRRIGATION OF LOCALIZED AREAS OF SOIL

2. A two-wire controlling and monitoring system for irrigation of localized areas of soil and comprising:a water pipeline configured for providing water to said localized areas of soil;
a plurality of controllable irrigation valves, each positioned at a specific area of said localized areas of soil, each connected to said water pipeline for providing watering or non-watering of said specific area of said localized areas of soil and each having a pair of valve control inputs;
a plurality of field sensors, positioned at specific areas of said localized areas of soil, and configured for providing specific irrigation parameters, each of said field sensors having a pair of sensor outputs;
a plurality of localized irrigation control units, each comprising at least one of (a) a sensor decoder having a pair of sensor inputs connected to said pair of sensor outputs of a specific field sensor of said plurality of field sensors and configured for providing power to said plurality of field sensors and recording said specific irrigation parameters from said plurality of field sensors and (b) a line decoder having a pair of valve control outputs connected to said pair of valve control inputs of a specific controllable irrigation valve of said plurality of controllable irrigation valves for providing valve control signals to said first plurality of controllable irrigation valves, said sensor decoder and said line decoder further each having a pair of control and power supply inputs;
a controller and power supply unit having a first set of schedules of instructions according to a first communications protocol and a second set of schedules of instructions according to a second communications protocol, said controller and power supply unit having a pair of control and power outputs supplying power by applying, respectively, in accordance with each of said first communications protocol and said second communications protocol, a first alternating DC voltage signal defining a voltage maximum having a first pulse width and defining a voltage minimum having a second pulse width to one of said pair of control and power outputs, simultaneously applying a second alternating DC voltage signal similarly shaped, but of inverted polarity as compared to said first alternating DC voltage signal to another of said pair of control and power outputs and applying an alternating DC current defining a current maximum having a third pulse width and defining a current minimum having a fourth pulse width to said pair of control and power outputs, wherein the first pulse width and second pulse width of the first communications protocol are different from the first pulse width and second pulse width of the second communications protocol;
a two-wire cable interconnecting said controller and power supply unit and said plurality of localized irrigation control units and connecting said pair of control and power outputs of said controller and power supply unit to said control and power inputs of said plurality of localized irrigation control units and providing said power from said controller and power supply unit to each of said plurality of localized irrigation control units;
said controller and power supply unit being configured for transmitting a type declaration to said plurality of localized irrigation control units through said two-wire cable using said first communications protocol, said type declaration providing communication under said second communications protocol;
said controller and power supply unit being configured for transmitting said second set of schedules of instructions to said plurality of localized irrigation control units through said two-wire cable using said second communications protocol; and
said controller and power supply unit being configured for transmitting said first set of schedules of instructions to said plurality of localized irrigation control units through said two-wire cable using said first communications protocol.

US Pat. No. 10,113,286

FLOOD VENT

SMART VENT PRODUCTS, INC....

1. A flood vent, comprising:a frame forming a fluid passageway through an opening in a structure;
a door pivotally mounted to the frame in the fluid passageway for allowing a fluid to flow through the fluid passageway, the door comprising an outer perimeter defined by a top edge, a bottom edge, and two side edges; and
one or more pieces of foam insulation extending at least substantially along an entire length of an inner perimeter of the frame, the one or more pieces of foam insulation being positioned on the inner perimeter of the frame in a location that is exterior to the door;
wherein the one or more pieces of foam insulation comprise a first piece of foam insulation positioned on a top interior edge of the frame, a second piece of foam insulation positioned on a bottom interior edge of the frame, a third piece of foam insulation positioned on a first side interior edge of the frame, and a fourth piece of foam insulation positioned on a second side interior edge of the frame, and
wherein the second piece of foam insulation positioned on the bottom interior edge of the frame includes one or more angled portions that are substantially parallel to one or more angled portions of the bottom edge of the door, wherein the angled portions of the second piece of foam insulation are dimensioned to prevent the door from contacting the second piece of foam insulation when the door is pivoted between an open position and a closed position.

US Pat. No. 10,113,284

BLADE FOR REMOVING SNOW

GILETTA S.P.A., Revello ...

1. A blade for removing snow from a road surface, the blade comprising:a shield defining a shield cavity oriented to deflect the snow;
at least one cutting edge coupled to a bottom part of said shield and adjacent to the road surface when in use, the at least one cutting edge including two walls defining an edge cavity within the at least one cutting edge, the two walls facing one another and being substantially parallel to one another; and
at least one fluid circuit comprising at least one nozzle, said at least one nozzle spreading a de-icing liquid and being positioned within the edge cavity or at least partially defined by the two walls of the edge cavity,
wherein the at least one nozzle is carried by said cutting edge to spread said de-icing liquid on the snow in an area selected from the group consisting of in front of and beneath said at least one cutting edge,
wherein said at least one cutting edge compresses snow mixed with said de-icing liquid during passage of said blade over said road surface.

US Pat. No. 10,113,280

AUTONOMOUS ROBOT APPARATUS AND METHOD FOR CONTROLLING THE SAME

Michael Todd Letsky, Boc...

1. An autonomous robot apparatus comprising:a chassis;
a plurality of wheels mounted to the chassis;
a drive system mounted to the chassis and operably coupled to the plurality of wheels;
a control module operably coupled to the drive system;
a precipitation sensing module comprising an accumulation cavity, wherein a floor of the accumulation cavity comprises at least one drainage aperture, an accumulation level sensor configured to generate and transmit, to the control module, a first signal upon a predetermined initial accumulation level of precipitation being detected, and wherein the predetermined initial accumulation level is an adjustable parameter that can be modified by an end user, wherein the accumulation level sensor comprises a plurality of sensors mounted on a wall of the accumulation cavity;
the control module configured to activate the autonomous robot apparatus to perform a first instance of a work routine upon receipt of the first signal;
the precipitation sensing module further configured to generate and transmit, to the control module, a second signal upon a predetermined secondary accumulation level of the precipitation being detected, the predetermined secondary accumulation level of the precipitation being a greater accumulation of the precipitation than the predetermined initial accumulation level of the precipitation;
the control module further configured to cause the autonomous robot apparatus to perform a second instance of the work routine, after completion of the first instance of the work routine, upon receipt of the second signal.

US Pat. No. 10,113,278

MODULE FOR DEICING A CABLE SHEATH AND METHOD FOR USING THE SAME

American Bridge Maintenan...

1. A module for placement inside a sheath having a longitudinal axis and for vibrating the sheath comprising a body having:a) a mass;
b) a vibrator attached to the mass;
c) a base supporting the mass and vibrator and adapted to contact an inner wall of the sheath; and
d) wherein the body has a tether attached thereto adapted for towing the body along the longitudinal axis of the sheath.

US Pat. No. 10,113,277

DEVICE FOR AUTOMATIC RE-STRIPING OF HORIZONTAL ROAD MARKINGS

1. A device for automatic re-striping of horizontal road markings and which can be attached to a vehicle, the device comprising:a marker unit with a linear actuator which is configured to position paint guns secured to a movable carriage over previous marking lines to be restriped, the linear actuator comprising a linear displacement transducer configured to determine coordinates of the paint guns;
an electronic control unit (14) electrically connected to the linear actuator (7), wherein the electronic control unit (14) comprises:
an electronic gyroscope (19) configured to determine an angular speed of the vehicle on curved road sections,
an electronic computation module configured to process signals received from said gyroscope and to generate signal values to be sent to a monitoring and control module,
said monitoring and control module being configured to process signals received from said linear displacement transducer, said monitoring and control module comprising drivers configured to control said linear actuator and drivers configured to control a position of solenoid valves, said solenoid valves being configured to enable and disable the paint guns, and
a near-sighting system comprising a laser scanner mounted in front of the marker unit and electrically connected to the electronic computation module, wherein the laser scanner emits a modulated beam and is configured to automatically identify coordinates of marking lines close to the paint guns, wherein the electronic computation module receives the coordinates of marking lines from the laser scanner, the electronic computation module being configured to automatically calculate a displacement between coordinates of the paint guns and coordinates of marking lines close to the paint guns, and based on said displacement, automatically send signal values to the monitoring and control module, said signal values controlling the position of said linear actuator and the position of said solenoid valves such that the paint guns automatically become positioned over corresponding marking lines,
wherein the electronic control unit is further configured to calculate and automatically offset, based on the angular speed of the vehicle, for an additional deviation of the paint guns from the coordinates of any of the marking lines when the vehicle moves on curved road sections.

US Pat. No. 10,113,276

COLD IN-PLACE RECYCLING MACHINE WITH SURGE TANK

Roadtec, Inc., Chattanoo...

1. A CIR-modified milling machine comprising:(a) a milling drum that is adapted to mill material from a roadway;
(b) a milling drum housing that contains the milling drum;
(c) an additive spray assembly that is located within the milling drum housing and adapted to dispense an asphalt additive therein;
(d) an additive flow system:
(i) which includes an inlet pipe that is adapted to be operatively connected to an external supply line;
(ii) comprising a surge tank for asphalt additive that is in fluid communication with the additive spray assembly;
(iii) comprising an additive pump for pumping asphalt additive from the surge tank to the additive spray assembly;
wherein the additive flow system includes piping and associated valves that permit operation of the additive flow system in a first mode in which the additive pump is adapted to draw asphalt additive from an external supply into the surge tank by means of the external supply line, and to pump the asphalt additive out of the surge tank to the additive spray assembly, and alternatively in a second mode in which the additive pump is adapted to draw asphalt additive from an external supply by means of the external supply line and to pump the asphalt additive out to the additive spray assembly while bypassing the surge tank.

US Pat. No. 10,113,273

INTERLOCKING HEATED PATIO STONES AND SYSTEM

1. A heated patio stone system comprising:a first patio stone interconnected to a second patio stone, wherein each patio stone comprises:
a load-supporting thermally-conductive upper layer;
an insulating lower layer;
an electrical heating cable positioned between the load-supporting thermally-conductive upper layer and the insulating lower layer;
an interconnection having a receptacle interconnected to the electrical heating cable positioned within said each patio stone; and
a bridging connector comprising:
an expandable and retractable articulated section containing an electrical wire connected to the electrical heating cable of each of the first patio stone and the second patio stone to electrically connect the first patio stone to the second patio stone:
a first basin on a first side of the expandable and retractable articulated section, closed by a first cap having a first electrical plug, the first electrical plug electrically connected to the electrical wire; and,
a second basin on a second side of the expandable and retractable articulated section, closed by a second cap having a second electrical plug, the second electrical plug electrically connected to the electrical wire;
wherein:
a length of the electrical wire from the first basin to the second basin is similar to a length of the bridging connector when the articulated section is in a fully expended state;
at least a portion of the electrical wire is contained in between the first basin and the second basin of the bridging connector when the expandable and retractable articulated section is in a fully retracted state; and,
the expandable and retractable articulated section of the bridging connector allows for limited movement of the first patio stone relative to the second patio stone.

US Pat. No. 10,113,271

DECORATION AND ADORNMENT METHODS FOR THERMOFORMED PULP

VARDEN PROCESS PTY LTD, ...

1. A method of forming a molded and printed product from pulp material including the steps of:a) forming a wet pulp pre-form from the pulp material;
b) applying a dry or cured printing decoration ink membrane bespoke coating to said wet pulp pre-form using an intermediate transfer surface, being separate and distinct from said pre-form, to form a printed pre-form;
c) transferring the printed pre-form to a mold; and
d) molding or re-molding said printed pre-form to form said molded and printed product.

US Pat. No. 10,113,268

INSTALLATION FOR DRYING A DAMP NON-WOVEN WEB

ANDRITZ PERFOJET SAS, Mo...

1. An installation for drying a non-woven web which comprises:a fan (6) with a delivery and an intake,
a heating oven (3) having an inlet and an outlet,
an inlet conduit (C1) which has a branch and which connects the delivery of the fan (6) with the inlet of the oven (3) and sends delivered air to the inlet of the oven,
a heat source (4) arranged in such a way that the air delivered in the inlet conduit (C1} is heated,
an outlet conduit (C2) which connects the outlet of the oven (3) with the intake of the fan (6),
a branch conduit (C3), in the branch of the inlet conduit (C1) upstream of the heat source (4), connecting the inlet conduit (C1) with an inlet of a drying device (10, 11),
a means of transport (2) which displaces a web in the drying device (10, 11) and in the oven (3), the drying device (10, 11) being upstream of the oven (3) in a direction of displacement of the web,
a conduit (C4) for extracting the air from the drying device (10, 11),
wherein the drying device comprises a diffusion chamber (10) having an outlet fitting (21) in which there is mounted a perforated sheet (24) which is mounted in a movable drawer (22) which has a handle (23) outside of the fitting (21),wherein downstream of the perforated sheet (24) is mounted in the outlet fitting (21) or in a channel which is clamped to the fitting (21) a honeycombed bundle (28), the dimension of whose cells is greater than that of the perforations of the perforated sheet (24).

US Pat. No. 10,113,267

TENSIONING APPARATUS FOR SYNTHETIC SLING MANUFACTURING APPARATUS AND METHOD

SlingMax, Inc., Aston, P...

1. A sling manufacturing apparatus for constructing a synthetic sling having a cover and a core with the core constructed of synthetic yarns, the apparatus comprising:a frame defining a longitudinal frame axis;
a yarn feeder assembly associated with the frame;
a drive roller connected to the frame, the drive roller being drivable to draw yarn from the yarn feeder assembly;
a tailstock movably mounted to the frame, the tailstock movable relative to the frame parallel to the longitudinal frame axis;
an idler roller movably mounted to the tailstock, the idler roller movable relative to the tailstock parallel to the longitudinal frame axis; and
an idler actuator comprised of a hydraulic actuator having a first cylinder, a first shaft, a second cylinder and a second shaft, the first shaft connected to a first end of the idler roller and the second shaft connected to a second end of the idler roller, the idler actuator secured to the tailstock and the idler roller, the idler actuator configured to move the idler roller from a loading position spaced at a first distance from the tailstock to a tensioned position spaced at a second distance from the tailstock, the first distance being greater than the second distance.

US Pat. No. 10,113,264

DEVICE ADAPTED TO MAINTAIN FORM AND ASSIST IN DRYING OF A GLOVE

1. A device for substantially maintaining the full form of a glove while facilitating drying of the glove, said device comprising a hand-shaped form having:a palm portion comprising a substantially planar flange having a first side and a second side; and
a plurality of finger flanges comprising: an index finger flange, a middle finger flange, a ring finger flange, and a pinky finger flange; each of said finger flanges configured to extend from said first end of said substantially planar flange of said palm portion;
a first peripheral flange configured to extend away from and be in continuous proximity to, a periphery formed by said first side of said palm portion and said plurality of finger flanges;
a second peripheral flange configured to extend away from and be in continuous proximity to, a periphery formed by said second side of said palm portion and said plurality of finger flanges;
a first transverse flange for each of said finger flanges, each configured to extend away from a first side thereof, and to be substantially centered on the finger flange;
a second transverse flange for each of said finger flanges, each configure to extend away from a first side thereof, and to be substantially centered on the finger flange; and
a thumb portion.

US Pat. No. 10,113,263

LAUNDRY TREATING APPLIANCE WITH IMAGING CONTROL

Whirlpool Corporation, B...

1. A laundry treating appliance for treating laundry according to an automatic treating cycle of operation, comprising:a laundry treating chamber receiving laundry for treatment;
at least one component operable to implement at least part of the automatic treating cycle of operation;
an imaging device mounted to the laundry treating appliance and having a sensor operably coupled with at least a portion of the laundry treating chamber during execution of the automatic treating cycle of operation and outputting data representative of at least a portion of the laundry in the laundry treating chamber;
an indicator configured to output a signal; and
a controller receiving the data and operably coupled to the indicator, the controller comprising analysis software that is configured to determine a motion condition of the laundry based on the data and the controller configured to determine a condition of concern of the laundry based on the data and to activate the indicator to emit a signal based on the determined condition to notify a user of the determined condition of concern.

US Pat. No. 10,113,262

DRYER APPLIANCES AND METHODS FOR DIAGNOSING RESTRICTIONS IN DRYER APPLIANCES

Haier US Appliance Soluti...

1. A method for diagnosing a restriction in a dryer appliance, the method comprising:obtaining a plurality of temperature readings at a controller of the dryer appliance during each operation of the dryer appliance by intermittently measuring a temperature of inlet air to the dryer appliance from a temperature sensor mounted within a cabinet of the dryer appliance;
obtaining a heater status for a heater of the dryer appliance at the controller during each measurement of the temperature;
estimating an effective opening size equal to or smaller in relation to an actual opening size of an outlet assembly in the dryer appliance at the controller during each operation of the dryer appliance based on the temperature and heater status for each of the plurality of temperature readings, the estimating comprising
calculating a heater contribution rate for temperature and a decay rate for temperature for the plurality of temperature readings at the controller utilizing the temperature and heater status for each of the plurality of temperature readings, and
utilizing at least one of the heater contribution rate for temperature and the decay rate for temperature to estimate the effective opening size; and
transmitting a restriction signal from the controller when the effective opening size is less than a predetermined minimum size threshold,
wherein the effective opening size is correlated to the at least one of the heater contribution rate for temperature or the decay rate for temperature,
wherein the heater contribution rate for temperature includes a rate of temperature increase at an active status of the heater, and
wherein the decay rate for temperature includes a rate of temperature decrease at an inactive status of the heater.

US Pat. No. 10,113,260

LAUNDRY TREATING APPLIANCE

Whirlpool Corporation, B...

1. A laundry treating appliance configured to implement a cycle of operation to treat a load of laundry, comprising:a basket defining a treating chamber and rotatable about an axis of rotation;
a motor having a rotor and a stator;
a shifter within an interior diameter of the stator and having an energizable clutch coil at least partially enveloped in a magnetically permeable housing and a magnetically permeable slidable drive mechanism radially spaced from the housing and configured to selectively couple the basket with the rotor; and
a concentric magnetically permeable ring located on the rotor, radially spaced and axially aligned with a portion of the magnetically permeable housing, and radially aligned and axially spaced from the slidable drive mechanism.

US Pat. No. 10,113,258

LAUNDRY TREATMENT APPARATUS

LG Electronics Inc., Seo...

1. A laundry treatment apparatus comprising:a housing;
a tub that is located inside the housing and that is configured to receive water;
a drum that is configured to rotate, that is located inside the tub, and that is configured to receive laundry; and
three or more tub support units that are each configured to connect the tub and the housing and that includes:
a first support member that is located at the housing;
a second support member that is located at the tub; and
a connector that is configured to connect the first support member and the second support member,
wherein the first support member of at least one of the three or more tub support units includes a first bracket that is detachably coupled to the housing and that is located adjacent to a first side of the tub, and
wherein the first support member of one or more remaining of the three or more tub support units includes a second bracket that is integrated with the housing and that is located adjacent to a second side of the tub that is opposite the first side of the tub.

US Pat. No. 10,113,257

MULTI-NEEDLE BAR MODULE FOR SEWING MACHINES

NINGBO SUPREME ELECTRONIC...

1. A multi-needle bar module for sewing machines, comprising a mounting plate adapted to a front end of a sewing machine head, characterized in that the mounting plate is equipped in a sliding manner, via a bracket, with a needle bar mounting frame on which at least two needle bars are distributed at intervals, the needle bars being in axial sliding fit with the needle bar mounting frame;the mounting plate is provided with a U-shaped first horizontal guideway and a U-shaped second horizontal guideway disposed at intervals and spaced apart, and a needle bar driving block with a neck is disposed between the first horizontal guideway and the second horizontal guideway; the needle bars are provided with guide members that can be clamped into the first horizontal guideway and the second horizontal guideway; the needle bar mounting frame clamps, by sliding horizontally, the guide of any one of the needle bars individually into the neck;
wherein the U-shaped first horizontal guideway and the U-shaped second horizontal guideway are positioned in a same plane such that sectional areas of the first horizontal guideway and the second horizontal guideway along the same plane are respectively in a U-shape, two free ends of two parallel arms of the U-shaped first horizontal guideway point to and are aligned with two free ends of two parallel arms of the U-shaped second horizontal guideway, respectively; a cuboid-shaped opening between the two parallel arms of the U-shaped first horizontal guideway and a cuboid-shaped opening between the two parallel arms of the second horizontal guideway oppose and are aligned with each other, the needle bar driving block with the neck is vertical to the same plane of the U-shaped first and second horizontal guideways; and
the two free ends of the two parallel arms of the U-shaped first horizontal guideway are not connected with the two free ends of the two parallel arms of the U-shaped second horizontal guideway.

US Pat. No. 10,113,255

NON-WOVENS WITH HIGH INTERFACIAL PORE SIZE AND METHOD OF MAKING SAME

1. A container of wipes comprising:a housing; and
a plurality of wipes at least partially overlapping one another and contained at least partially within the housing;
wherein a surface of each of the plurality of wipes includes a continuous raised portion and a plurality of discrete recessed portions;
the continuous raised portion of a first wipe being configured to prevent its continuous raised portion from nesting within the plurality of recessed portions of an adjacent second wipe; andwherein an average pore-size of the interface between the first and second wipes is greater than 180 microns in radius.

US Pat. No. 10,113,254

DISPERSIBLE MOIST WIPE

KIMBERLY-CLARK WORLDWIDE,...

1. A dispersible moist wipe comprising a nonwoven tissue web having regenerated fibers in an amount of about 10 to about 30 percent by weight and natural fibers in an amount of about 70 to about 90 percent by weight, wherein the regenerated fibers and the natural fibers are hydroentangled using an energy within a range between about 0.12 kw-hr/kg and about 0.9 kw-hr/kg such that the web has a geometric mean tensile strength of at least 150 grams per inch and a slosh-box break-up time of less than 155 minutes, the nonwoven tissue web being free of a binder and having a formation value of at least 12, wherein the nonwoven tissue web has at least one ribbon-like structure extending along the nonwoven tissue web, and at least one hole in the nonwoven tissue web positioned adjacent the at least one ribbon-like structure, the at least one ribbon-like structure defining an area of higher entanglement of the regenerated fibers and the natural fibers than in other areas of the nonwoven tissue web.

US Pat. No. 10,113,253

METHOD AND APPARATUS FOR FABRICATING SUSCEPTOR COIL ASSEMBLIES

The Boeing Company, Chic...

1. An apparatus for fabricating a susceptor coil assembly, the apparatus comprising:a tensioning section;
a feeding section configured for feeding a conductor wire toward the tensioning section, the tensioning section being configured for maintaining a desired tension of the conductor wire; and
a coiling section configured for winding a susceptor wire around an outer surface of the conductor wire so as to fabricate a susceptor coil assembly as the conductor wire moves from the feeding section toward the tensioning section, the coiling section comprising a winder head comprising:
a first wire inlet configured for receiving the conductor wire from the feeding section; and
a second wire inlet that extends radially from the first wire inlet and is configured for radially receiving the susceptor wire as the coiling section winds the susceptor wire and for receiving the conductor wire as the conductor wire moves toward the tensioning section.

US Pat. No. 10,113,252

SYSTEMS AND METHODS FOR IMPROVING AND CONTROLLING YARN TEXTURE

COLUMBIA INSURANCE COMPAN...

1. A yarn system for controlling and improving the consistency of a texture of yarn, the yarn system comprising:a texturing apparatus configured for imparting a desired texture in the yarn, wherein the texturing apparatus comprises:
a stuffer box defining an internal chamber having an inlet end and an outlet end through which the yarn passes,
a climate chamber positioned downstream of the stuffer box, wherein the climate chamber sets the desired texture in the yarn, and
a source of compressed gas in fluid communication with the internal chamber of the stuffer box, wherein the compressed gas is configured to move the yarn from the inlet end toward the outlet end of the internal chamber of the stuffer box;
a plurality of rollers for moving the yarn through the yarn system, wherein at least one roller of the plurality of rollers is coupled to and driven by at least one roller motor, wherein the plurality of rollers comprise:
at least one delivery roller driven by a delivery motor and configured to deliver the yarn to the inlet end of the internal chamber of the stuffer box, and
at least one overfeed roller driven by an overfeed motor configured to deliver the yarn to the at least one delivery roller;
a plurality of sensors, each sensor of the plurality of sensors configured to sense an operating parameter of the yarn system, the plurality of sensors comprising:
at least one transport air pressure sensor configured to sense the pressure of the compressed gas supplied by the source of compressed gas in fluid communication with the internal chamber, wherein the at least one transport air pressure sensor is coupled to a processor,
at least one vacuum fan positioned downstream of the climate chamber and configured to cool the yarn after the yarn exits the climate chamber, and
at least one yarn temperature sensor configured to sense the temperature of the yarn after the yarn is cooled by the at least one vacuum fan, wherein the at least one yarn temperature sensor is coupled to the processor,
wherein the processor is configured to stop operation of the yarn system when the at least one transport air pressure sensor senses a pressure outside of a transport air pressure tolerance for a first amount of time; and
a plurality of additional sensors coupled to the processor and configured to sense additional operating parameters of the yarn system, wherein the processor is configured to stop operation of the yarn system when an additional sensor of the plurality of additional sensors senses an operating parameter outside of a tolerance for the additional sensor for a second amount of time,
wherein the at least one overfeed motor delivers the yarn to the at least one delivery roller, and wherein the at least one delivery roller delivers the yarn to the inlet end of the internal chamber of the stuffer box.

US Pat. No. 10,113,251

SLIVER GUIDE FOR A DRAWING FRAME, AND A DRAWING FRAME WITH THE SILVER GUIDE

Rieter Ingolstadt GmbH, ...

1. A sliver guide for guiding a multiple number of fiber slivers in an entrance area of a draw frame, comprising:a first guide section disposed to guide a first group of fiber slivers;
a second guide section disposed to separately guide a second group of fiber slivers;
in a side view of the sliver guide, the first guide section and the second guide section spaced apart from each other in one or both of a vertical direction or a transport direction of the fiber slivers through the sliver guide;
a third guide section spaced apart from the first guide section and the second guide section in the side view in one or both of the vertical direction or the transport direction of the fiber slivers through the sliver guide;
first lateral guide elements configured with at least one of the guide sections, wherein a lateral distance between the first lateral guide elements is adjustable.

US Pat. No. 10,113,250

MODIFICATION OF CONTINUOUS CARBON FIBERS DURING MANUFACTURING FOR COMPOSITES HAVING ENHANCED MOLDABILITY

GM GLOBAL TECHNOLOGY OPER...

1. A method of manufacturing a continuous carbon fiber for use in composites having enhanced moldability, the method comprising:introducing a continuous precursor fiber comprising a polymer material into a heated environment; and
directing laser energy towards a plurality of discrete target regions of the continuous precursor fiber while in the heated environment to create a continuous carbon fiber having a plurality of discrete weak regions corresponding to the plurality of discrete target regions.

US Pat. No. 10,113,248

GROUP III NITRIDE CRYSTAL SUBSTRATE, EPILAYER-CONTAINING GROUP III NITRIDE CRYSTAL SUBSTRATE, SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME

Sumitomo Electric Industr...

1. A wafer comprising a semiconductor device structure including a group III nitride crystal substrate and at least one semiconductor layer provided by epitaxial growth on a main surface of said crystal substrate, wherein,a plane spacing of arbitrary specific parallel crystal lattice planes of said crystal substrate being obtained from X-ray diffraction measurement performed with variation of X-ray penetration depth from a main surface of said crystal substrate while X-ray diffraction conditions of said specific parallel crystal lattice planes of said crystal substrate are satisfied,
a uniform distortion at a surface layer of said crystal substrate represented by a value of |d1?d2|/d2 is equal to or lower than 1.7×10?3 where d1 indicates a plane spacing at said X-ray penetration depth of 0.3 ?m and d2 indicates a plane spacing at said X-ray penetration depth of 5 ?m, and wherein
a plane orientation of said main surface has an inclination angle equal to or greater than ?10° and equal to or smaller than 10° in a [0001] direction with respect to any of {10-10}, {11-20} and {21-30} planes of crystal substrate,
wherein said semiconductor layer includes a light emitting layer emitting light having a peak wavelength equal to or more than 500 nm and equal to or less than 550 nm.

US Pat. No. 10,113,247

SEMICONDUCTOR SINGLE CRYSTAL PULLING APPARATUS AND METHOD FOR REMELTING SEMICONDUCTOR SINGLE CRYSTAL USING THIS

SHIN-ETSU HANDOTAI CO., L...

1. A method for remelting a semiconductor single crystal which is a method for immersing a lower end portion of the semiconductor single crystal in a melt and remelting the same by using a single crystal pulling apparatus, the single crystal pulling apparatus comprising a heater for performing heating and thermal insulation to a crucible containing a melt and a wire for growing a semiconductor single crystal while pulling the same from the melt,wherein the semiconductor single crystal pulling apparatus comprises:
a remelting detection apparatus which detects that remelting of a lower end portion of the semiconductor single crystal is completed from a change in weight of the semiconductor single crystal when the lower end portion of the semiconductor single crystal is immersed in the melt so as to be remolten by using the wire; and
a lowermost end detection apparatus which detects a lowermost end of the semiconductor single crystal from a position where no current flows between the semiconductor single crystal and the melt when the semiconductor single crystal is taken up with the use of the wire while applying a voltage between the semiconductor single crystal and the melt by applying a voltage between the crucible and the wire,
the method comprising:
a crystal immersion step of immersing the lower end portion of the semiconductor single crystal in the melt and remelting the lower end portion by lowering the wire of the single crystal pulling apparatus;
a remelting detection step of detecting that melting of the lower end portion of the semiconductor single crystal immersed in the melt is completed from a change in weight of the semiconductor single crystal by using the remelting detection apparatus;
a lowermost end detection step of taking up the semiconductor single crystal with the use of the wire while applying a voltage between the semiconductor single crystal and the melt, and detecting a lowermost end of the semiconductor single crystal from a position where no current flows between the semiconductor single crystal and the melt by using the lowermost end detection apparatus; and
a determination step of determining whether the crystal immersion step is to be restarted or whether the remelting is to be terminated after end of the lowermost end detection step.

US Pat. No. 10,113,246

SUBSTRATE HOLDER, PLATING APPARATUS, AND PLATING METHOD

EBARA CORPORATION, Tokyo...

1. A substrate holder comprising:inner contacts to be brought into contact with a periphery of a substrate for passing an electric current to the substrate;
outer contacts each having elasticity, the outer contacts having contact surfaces, respectively, to be brought into contact with a feeding terminal coupled to a power source, the outer contacts being coupled to the inner contacts, respectively; and
a conductive block arranged in back of the contact surfaces having a first position not in contact with the outer contacts,
wherein the outer contacts are deformable until the outer contacts are brought into contact with the conductive block in a second position when the contact surfaces are pressed against the feeding terminal.

US Pat. No. 10,113,245

ELECTROPLATING CONTACT RING WITH RADIALLY OFFSET CONTACT FINGERS

Applied Materials, Inc., ...

1. An electroprocessing apparatus comprising:a head;
a rotor in the head;
an annular contact ring attachable onto the rotor;
a frame including a vessel, with the head movable to position the annular contact ring in the vessel and out of the vessel;
a plurality of first contact fingers aligned on the annular contact ring, with each of the first contact fingers having a first length;
a plurality of second contact fingers aligned on the annular contact ring, with each of the second contact fingers having a second length less than the first length;
wherein each of the plurality of first and second contact fingers are aligned on a radius of the annular contact ring and extend radially inwardly from the annular contact ring; and
wherein the plurality of first and second contact fingers are arranged in a plurality of clusters disposed substantially around an entire diameter of the annular contact ring, with each cluster including one first contact finger and one second contact finger.

US Pat. No. 10,113,241

CONTROL BOARD FOR CONTROLLING CHANNEL SEQUENCING OF POSITIVE AND NEGATIVE DC VOLTAGE AND CURRENT

1. A system for controlling sequencing of positive and negative DC voltage and current to release hydrogen gas from water consisting of:a power cable for delivery of power;
one or more stainless steel plate or groups of stainless steel plates consisting of a center hole, to accommodate the power cable for delivery power to the stainless steel plate, surrounded by a continuous flat surface where the flat surface has four equal straight sides forming a square;
a controller board consisting of:
a processing circuit;
a memory device coupled to the processing circuit, the memory device programmed by the processing circuit to deliver one or more sequences to the one or more stainless steel plates or groups of stainless steel plates, the one or more sequences defining the order in which power is delivered to the one or more devices or groups of devices;
a first plurality of two position terminal blocks connected to pairs of positive drive outputs of a first group of transistors for providing a power connection to the one or more devices or groups of devices;
a second plurality of two position terminal blocks connected to pairs of negative drive outputs of a second group of transistors for providing a ground connection to the one or more devices or groups of devices;
a manual run/program switch assembly, in communication with the processing circuit, operable between a run position and a program position, wherein the run position causes the controller board to follow a pre-programmed sequence and wherein the program position allows for the programming of a new sequence;
a display, connected to the processing circuit, for displaying the current sequence;
a first plurality of visual indicators connected to the negative drive outputs for identifying which negative output channels is currently activated;
a second plurality of visual indicators connected to the positive drive outputs for identifying which positive output channel is currently activated;
a first plurality of electric dip switches in communication with the processing circuit for programming which of the positive drive outputs to turn On at each step in the sequence, the number of the first plurality of electric dip switches corresponds to the total number of positive drive outputs;
a second plurality electric dip switches in communication with the processing circuit for programming which of the negative drive outputs to turn On at each step in the sequence, the number of the second plurality of electric switches corresponds to the total number of negative drive outputs;
a save button, an up button, a down button and a select button in communication with the processing circuit for programming and saving and the sequences of the positive drive outputs and the negative drive outputs as defined by the first plurality of electronic dip switches and the second plurality of electronic dip switches; and
wherein the one or more stainless steel plates or groups of stainless steel plates are submerged in the water.

US Pat. No. 10,113,240

CATHODIC PROTECTION SYSTEM MONITORING

Stratocom Solutions Corpo...

1. A method for testing a cathodic protection system for a metallic structure that has associated therewith a first set of locations, each location of the first set of locations including a testing module, electrically connected to the metallic structure, and an associated reference electrode, the method comprising, for each location of the first set of locations:periodically, at a first frequency, interrupting power provided at each location of the first set of locations to cause power provided to the metallic structure to switch on and off a plurality of times over a testing time period;
measuring, by each testing module, DC voltage differentials between the metallic structure and its associated reference electrode when the power provided to the metallic structure is on and when the power provided to the metallic structure is off, at a plurality of times during a plurality of interruption cycles, wherein measuring DC voltage differentials between the metallic structure and its associated reference electrode when the power provided to the metallic structure is off is asynchronous to interrupting power to the metallic structure, and wherein initiation of each of the interruption cycles is independent of interrupting power provided at each location of the first set of locations;
storing in a digital storage medium at each testing module, digital values associated with the measured DC voltage differentials during the interruption cycles; and
providing at least selected digital values to a remotely located device upon request by the remotely located device.

US Pat. No. 10,113,239

CUTTING TOOL

KYOCERA CORPORATION, Kyo...

1. A cutting tool comprising:a base including cemented carbide containing W, C, Co, Cr, Si and Fe; and
a coating layer comprising a Ti-based layer including at least a layer of Ti(Cx1Ny1Oz1) (0?x1?1, 0?y1?1, 0?z1?1, x1+y1+z1=1), an Al2O3 layer, and an outermost layer of Ti(Cx3Ny3Oz3) (0?x3?1, 0?y3?1, 0?z3?1, x3+y3+z3=1), which are laminated in order from the base side on a surface of the base, wherein a content of Cr contained at a thickness-center position of a first Ti-based layer of the Ti-based layer on a side closer to the base is lower than a content of Cr contained in the base, and higher than a content of Cr contained at a thickness-center position of the Al2O3 layer, and a content of Cr contained at a thickness-center position of the outermost layer is higher than the content of Cr contained at the thickness-center position of the Al2O3 layer in a glow-discharge emission spectrometry (GDS analysis).

US Pat. No. 10,113,237

MANUFACTURING METHOD OF ROTATING MACHINE, PLATING METHOD OF ROTATING MACHINE, AND ROTATING MACHINE

MITSUBISHI HEAVY INDUSTRI...

1. A manufacturing method of a rotating machine comprising:a casing forming process of forming a casing of the rotating machine that has multiple openings and suctions and discharges a fluid;
a surface activating process of supplying a pretreatment liquid into the casing through the openings, then discharging the pretreatment liquid from the casing through the openings, and activating an inner surface of the casing after the casing forming process;
a preheating process of supplying a preheating liquid into the casing through the openings, then discharging the preheating liquid from the casing through the openings, and preheating the casing after the surface activating process;
a plating process of performing supply and discharge of a plating liquid into and from the casing through the openings to circulate the plating liquid and plating the inner surface of the casing after the preheating process; and
an assembling process of providing a rotating body that is rotatable relative to the casing such that the rotating body is covered from an outer circumference side by the casing plated in the plating process,
wherein, in the surface activating process, the preheating process, and the plating process, each of the pretreatment liquid, the preheating liquid, and the plating liquid corresponding to each process is supplied into the inner surface of the casing in a range above a liquid level of each of the pretreatment liquid, the preheating liquid, and the plating liquid corresponding to each process in the casing by a treatment liquid auxiliary supply device separately from each of the pretreatment liquid, the preheating liquid, and the plating liquid corresponding to each process which is supplied from the openings of the casing, and
the treatment liquid auxiliary supply device is vertically moved according to a vertical change of the liquid level of each of the pretreatment liquid, the preheating liquid, and the plating liquid corresponding to each process in the casing.

US Pat. No. 10,113,236

BATCH CURING CHAMBER WITH GAS DISTRIBUTION AND INDIVIDUAL PUMPING

APPLIED MATERIALS, INC., ...

1. A batch substrate processing chamber, comprising:multiple sub-processing regions that are each configured to receive a substrate from an atmospheric robot and to perform a curing process on the substrate received from the atmospheric robot;
a loading opening formed in a wall of the batch processing chamber;
a first door disposed over the loading opening; and
a cover plate disposed over the loading opening comprising multiple slotted openings, wherein
the first door is disposed over all of the multiple slotted openings,
the first door is configured to seal the loading opening with a sealing surface that encompasses the multiple slotted openings,
each of the slotted openings are configured to allow at least one atmospheric robot to extend an arm from a position outside of the batch processing chamber to one of the multiple sub-processing regions, and
each of the multiple slotted openings are configured to reduce the free area of the loading opening when the loading opening is open.

US Pat. No. 10,113,234

UV ASSISTED SILYLATION FOR POROUS LOW-K FILM SEALING

APPLIED MATERIALS, INC., ...

1. A method for forming a sealing layer, comprising:delivering UV energy to a substrate disposed in a process chamber, wherein a porous low-k dielectric film is disposed on the substrate;
forming an intermediate sealing layer, wherein forming the intermediate sealing layer sequentially comprises:
flowing a first precursor compound into the process chamber while delivering UV energy to the porous low-k dielectric film disposed on the substrate, wherein the first precursor compound comprises acetoxytrimethylsilane or dimethylaminotrimethylsilane;
stopping the flow of the first precursor compound;
flowing a second precursor compound into the process chamber while delivering UV energy to the porous low-k dielectric film disposed on the substrate, wherein the second precursor compound comprises diacetoxydimethylsilane or bis(dimethylamino)dimethylsilane; and
exposing the substrate to UV energy after flowing the second precursor compound to cure the intermediate sealing layer; and
repeating the forming of the intermediate sealing layer to form additional intermediate sealing layers.

US Pat. No. 10,113,230

FORMATION METHOD OF HEXAGONAL BORON NITRIDE THICK FILM ON A SUBSTRATE AND HEXAGONAL BORON NITRIDE THICK FILM LAMINATES THEREBY

KOREA INSTITUTE OF SCIENC...

1. A method of forming a multilayer hexagonal boron nitride (h-BN) thick film on a substrate, the method comprising:(a) a substrate heating step of heating a first substrate comprising iron (Fe);
(b) a h-BN precursor supply step of supplying h-BN precursors comprising borazine (H3B3N3H3) to the heated first substrate;
(c) a precursor dissolving step of dissolving the supplied h-BN precursors in the first substrate;
(d) a substrate cooling step of cooling the first substrate containing the dissolved h-BN precursors therein; and
(e) a formation step of multilayer h-BN thick film on a surface of the first substrate from the dissolved h-BN precursors therein.

US Pat. No. 10,113,228

METHOD FOR CONTROLLING SEMICONDUCTOR DEPOSITION OPERATION

TAIWAN SEMICONDUCTOR MANU...

1. A method for controlling a semiconductor deposition operation, comprising:identify a normalized full service target lifetime according to off-line measurements;
identifying a first target lifetime by a controller in a physical vapor deposition (PVD) system, the first target lifetime being identified at about 0.43 of the normalized full service target lifetime;
inputting the first target lifetime into a processor;
outputting, by the processor, a reactive gas flow rate according to a segment corresponding to the first target lifetime of a compensation curve, the compensation curve being predetermined and stored in a memory device of the controller; and
tuning the reactive gas flow rate in the PVD system so as to achieve an atomic ratio of target material and reactive gas of a deposited layer close to unity at the first target lifetime.

US Pat. No. 10,113,227

CRUCIBLE

BOE TECHNOLOGY GROUP CO.,...

1. A crucible, comprising a main cavity, wherein the crucible further comprises a plurality of sub-cavities which are arranged in the main cavity and are used for containing solid evaporation material, each of the sub-cavities being provided with an opening,wherein between any two adjacent sub-cavities, a conduit for mutual communication between said two adjacent sub-cavities is arranged and a through hole is formed on a side wall of each of the two adjacent sub-cavities at a position that connects the through hole with the conduit,
wherein the through hole penetrates a side of each of the two adjacent sub-cavities at a position below the respective opening,
wherein the conduit is detachably fixed to the side wall of each of the two adjacent sub-cavities by a connecting device,
wherein the conduit is made of a same material as the main cavity and the sub-cavities, and
wherein a switch shutter is provided on the side wall of each of the two adjacent sub-cavities and aligned with the through hole formed on each of the two adjacent sub-cavities.

US Pat. No. 10,113,226

SPALLATION-RESISTANT THERMAL BARRIER COATING

United Technologies Corpo...

1. A coated article comprising:a metallic substrate (22);
a bondcoat (30) comprising:
a first layer (32); and
a second layer (34), the first layer being between the second layer and the metallic substrate and having a lower Cr content than the second layer; and
a thermal barrier coating (TBC) (28),wherein by weight percent:the bondcoat second layer comprises 20-40 Cr, up to 30 Co, 5-13 Al, up to 2 Y, up to 2 Si, and up to 2 Hf, balance Ni with less than 2.0 individually and less than 5.0 aggregate other elements, if any; and
the bondcoat first layer comprises 1.0-30 Cr, up to 30 Co, 3-35 Al, 0.1-2 Y, 0.1-2 Hf, 0.1-7 Si, up to 8 Ta, up to 8 W, up to 2 Mo, and up to 2 Zr, balance Ni with less than 2.0 individually and less than 5.0 aggregate other elements, if any.

US Pat. No. 10,113,223

HOT-DIP GALVANIZED STEEL SHEET

1. A hot-dip galvanized steel sheet comprising:a steel sheet; and
a hot-dip galvanized layer formed on at least one surface of the steel sheet,
the steel sheet includes:
a chemical composition comprising, % by mass:
C: 0.040% to 0.280%,
Si: 0.05% to 2.00%,
Mn: 0.50% to 3.50%,
P: 0.0001% to 0.1000%,
S: 0.0001% to 0.0100%,
Al: 0.001% to 1.500%,
N: 0.0001% to 0.0100%,
O: 0.0001% to 0.0100%, and
a remainder of Fe and impurities;
wherein in a range of ? thickness to ? thickness centered at a position of ¼ thickness from the surface of the steel sheet, by volume fraction, said steel sheet includes:
0 to 50% of a ferrite phase,
a total of 50% or more of a hard structure comprising one or more of a bainite structure, a bainitic ferrite phase, a fresh martensite phase and a tempered martensite phase,
a residual austenite phase is 0 to 8%, and
a total of a pearlite phase and a coarse cementite phase is 0 to 8%,
wherein in a surface layer range of 20 ?m depth in a steel sheet direction from an interface between the hot-dip galvanized layer and a base steel, said steel sheet includes:
a residual austenite is 0 to 3%,
wherein the base steel sheet includes:
a microstructure in which V1/V2 which is a ratio of a volume fraction V1 of the hard structure in the surface layer range and a volume fraction V2 of the hard structure in the range of ? thickness to ? thickness centered at the position of ¼ thickness from the surface of the base steel sheet is limited within a range of 0.10 or more and 0.90 or less,
a Fe content is 5.0% or less and an Al content is 1.0% or less in the hot-dip galvanized layer, and columnar grains formed of a ? phase are included, and further
a ratio ((A*/A)×100) of an interface (A*) between the ? phase and the base steel sheet in an entire interface (A) between the hot-dip galvanized plated layer and the base steel sheet is 20% or more, and
a refined layer is formed at the side of the interface in the base steel sheet, wherein an average thickness of the refined layer is 0.1 to 5.0 ?m, an average grain size of ferrite in the refined layer is 0.1 to 3.0 ?m, one or two or more of oxides of Si and Mn are contained, and a maximum size of the oxide is 0.01 to 0.4 ?m.

US Pat. No. 10,113,216

QUASICRYSTAL AND ALUMINA MIXED PARTICULATE REINFORCED MAGNESIUM-BASED COMPOSITE MATERIAL AND METHOD FOR MANUFACTURING THE SAME

NORTH UNIVERSITY OF CHINA...

1. A quasicrystal and alumina mixture particles reinforced magnesium matrix composite comprising:a quasicrystal and alumina mixture particles reinforcement phase; and
a magnesium alloy matrix;
the weight ratio of the quasicrystal and alumina mixture particles reinforcement phase to the magnesium alloy matrix being (4-8) to 100,
the magnesium alloy matrix comprising by weight 1000 parts of magnesium, 90 parts of aluminum, 10 parts of zinc, 1.5-5 parts of manganese, 0.5-1 part of silicon and 0.1-0.5 part of calcium, and
the quasicrystal and alumina mixture particles reinforcement phase comprising by weight 40 parts of magnesium, 50-60 parts of zinc, 5-10 parts of yttrium and 8-20 parts of nanometer alumina particles of which the diameter is 20-30 nm.

US Pat. No. 10,113,215

MAKING MINERAL SALTS FROM VARIOUS SOURCES

LIXIVIA, INC., Santa Bar...

1. A mixture utilized in lixiviant extraction of a metal hydroxide forming species from a raw material comprising:a raw material comprising an insoluble metal salt, wherein the insoluble metal salt comprises the metal hydroxide forming species; and
a lixiviant solution comprising an organic amine cation and a counterion,
wherein the lixiviant solution is formulated to transfer the counterion to the insoluble metal salt to form an uncharged organic amine, and wherein the uncharged organic amine is formulated to react with an acid to regenerate the organic amine cation, and
wherein the organic amine cation is present in a substoichiometric amount relative to the insoluble metal salt.

US Pat. No. 10,113,211

METHOD OF MAKING A DUAL HARDNESS STEEL ARTICLE

ATI PROPERTIES LLC, Alba...

1. A method of manufacturing a dual hardness steel article, comprising:providing a first air hardenable steel alloy part comprising a first mating surface and having a first part hardness;
providing a second air hardenable steel alloy part comprising a second mating surface and having a second part hardness, wherein the first part hardness is greater than the second part hardness;
disposing the first air hardenable steel alloy part and the second air hardenable steel alloy part so that at least a portion of the first mating surface contacts at least a portion of the second mating surface;
metallurgically securing the first air hardenable steel alloy part to the second air hardenable steel alloy to form a metallurgically secured assembly;
hot rolling the metallurgically secured assembly to form a metallurgical bond between the first mating surface and the second mating surface; and
cooling the hot rolled assembly.

US Pat. No. 10,113,210

HEAT TREATMENT APPARATUS FOR CYLINDER BLOCK AND HEAT TREATMENT METHOD FOR CYLINDER BLOCK

TOYOTA JIDOSHA KABUSHIKI ...

1. A heat treatment apparatus for a cylinder block, the heat treatment apparatus performing heat treatment by feeding gas, the heat treatment apparatus comprising:a first feed part configured to feed the gas toward bores of the cylinder block, from a first side or a second side of the bores in an axis direction of the bores; and
a second feed part configured to feed the gas toward a lateral surface of the cylinder block from the first side or the second side, the lateral surface of the cylinder block extending in an array direction of the bores,
wherein the first feed part includes a first feed hole that is a jet orifice for the gas,
wherein the second feed part includes a second feed hole that is a jet orifice for the gas, and
wherein at least one of the first feed hole and the second feed hole is a slit along the array direction of the bores of the cylinder block.

US Pat. No. 10,113,209

METHODS AND SYSTEMS FOR PRODUCING HIGH CARBON CONTENT METALLIC IRON USING COKE OVEN GAS

MIDREX TECHNOLOGIES, INC....

1. A method for producing high carbon content metallic iron using coke oven gas, comprising:dividing a top gas stream from a direct reduction shaft furnace into a first top gas stream and a second top gas stream;
treating a coke oven gas stream from a coke oven gas source in one or more guard vessels to remove liquid droplets, aerosols, and heavy hydrocarbons from the coke oven gas stream;
mixing the first top gas stream with the treated coke oven gas stream and processing at least a portion of a resulting combined gas stream in a selective separation unit to form a synthesis gas-rich gas stream and a carbon-dioxide rich gas stream;
delivering the synthesis gas-rich gas stream to the direct reduction shaft furnace as bustle gas;
using the carbon-dioxide rich gas stream as fuel gas in one or more heating units;
delivering the second top gas stream to the direct reduction shaft furnace as bustle gas; and
delivering at least a portion of the coke oven gas stream to the direct reduction shaft furnace as a transition zone gas stream at a temperature that is lower than a temperature of the bustle gas.

US Pat. No. 10,113,195

NUCLEIC ACID AMPLIFICATION

LIFE TECHNOLOGIES CORPORA...

1. A method for amplifying a plurality of nucleic acid templates, comprising:a) providing a plurality of forward primers immobilized on a support, wherein the plurality of forward primers includes a first forward primer and a second forward primer, and wherein the plurality of forward primers have substantially identical sequences;
b) providing a nucleic acid reverse strand from the plurality of nucleic acid templates, having a forward primer-binding sequence that can hybridize to any one of the plurality of forward primers;
c) hybridizing the first forward primer to the forward primer-binding sequence on the nucleic acid reverse strand;
d) generating an extended forward strand that is substantially complementary to the nucleic acid reverse strand and is hybridized thereto, by primer extension of the first forward primer using the reverse strand as a template, wherein the first forward primer becomes incorporated into the extended forward strand;
e) denaturing at least a portion of the extended forward strand comprising the incorporated first forward primer and the forward primer-binding sequence on the nucleic acid reverse strand and hybridizing the second forward primer to the forward primer-binding sequence on the nucleic acid reverse strand;
f) generating another extended forward strand that is substantially complementary to the reverse strand and is hybridized thereto, by primer extension of the second forward primer using the reverse strand as a template, wherein the second forward primer becomes incorporated into the extended forward strand; and
g) amplifying the plurality of nucleic acid templates simultaneously in a single continuous liquid phase without first compartmentalizing, by performing one or more amplification cycles comprising steps (e)-(f) under isothermal conditions to form clonal or substantially clonal nucleic acid populations, wherein the incorporated second forward primer of step (e) of an amplification cycle acts as the incorporated first forward primer of step (e) of a subsequent amplification cycle and the second forward primer of step (e) in the subsequent amplification cycle is a new second forward primer that has not undergone primer extension; and wherein the amplifying is carried out using a recombinase and a polymerase.

US Pat. No. 10,113,189

ISOLATION AND CHARACTERIZATION OF A NOVEL PYTHIUM OMEGA 3 DESATURASE WITH SPECIFICITY TO ALL OMEGA 6 FATTY ACIDS LONGER THAN 18 CARBON CHAINS

BASF Plant Science GmbH, ...

1. A method for the manufacture of a composition comprising a compound having a structure of the general formula I:
wherein
R1=hydroxyl, coenzyme A (thioester), lysophosphatidylcholine, lysophosphatidylethanolamine, lysopho sphatidylglycerol, lysodipho sphatidylglycerol, lysopho sphatidylserine, lysophosphatidylinositol, sphingo base or a radical of the formula II:

R2=hydrogen, lysophosphatidylcholine, lysophosphatidylethanolamine, lysopho sphatidylglycerol, lysodipho sphatidylglycerol, lysopho sphatidylserine, lysophosphatidylinositol or saturated or unsaturated C2-C24-alkylcarbonyl, R3=hydrogen, saturated or unsaturated C2-C24-alkylcarbonyl, or R2 and R3 independently of each other are a radical of the formula Ia:

n=2, 3, 4, 5, 6, 7 or 9, m=2, 3, 4, 5 or 6 and p=0 or 3;
and
wherein said method comprises cultivating a host cell or a transgenic non-human organism comprising a polynucleotide comprising a heterologous nucleic acid sequence selected from the group consisting of:
(i) the nucleic acid sequence of SEQ ID NO: 1 or 23;
(ii) a nucleic acid sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 2 or 24; and
(iii) a nucleic acid sequence encoding a polypeptide having omega-3 desaturase activity capable of converting omega-6 DPA into DHA, wherein said polypeptide has at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 2 or 24,
under conditions which allow biosynthesis of said compound.

US Pat. No. 10,113,164

PICHIA PASTORIS SURFACE DISPLAY SYSTEM

Research Corporation Tech...

1. A surface display system comprising:(a) an engineered strain of Pichia pastoris comprising a mutant ?-1,6-mannosyltransferase (OCH1) allele which is transcribed into a mRNA coding for a mutant OCH1 protein, wherein the mutant OCH1 protein comprises a catalytic domain at least 95% identical with amino acids 45-404 of SEQ ID NO: 2, wherein the mutant OCH1 protein lacks an N-terminal sequence for targeting the mutant OCH1 protein to the Golgi apparatus and lacks a membrane anchor domain at the N-terminal region, and wherein said strain produce substantially homogeneous N-glycans; and
(b) a vector encoding a recombinant protein adapted to be displayed on a surface of the Pichia pastoris.

US Pat. No. 10,113,160

CARBON DIOXIDE FIXATION VIA BYPASSING FEEDBACK REGULATION

Easel Biotechnologies, LL...

1. A method for improving the efficiency of carbon dioxide fixation in an organism having a Calvin-Benson-Bassham (CBB) cycle, comprising:genetically modifying the organism having the CBB cycle to produce or overexpress a first enzyme, and to produce or overexpress a second enzyme;
wherein the first enzyme is phosphoketolase enzyme, belonging to EC 4.1.2.9 and the second enzyme is phosphoribulokinase enzyme belonging to EC 2.7.1.19;
wherein the first enzyme utilizes an intermediate of the CBB pathway as a substrate and generates a first acetyl phosphate product;
wherein the phosphoribulokinase enzyme is produced or overexpressed in an amount to achieve a phosphoribulokinase activity level that is higher than the native phosphoribulokinase activity level of the organism;
wherein the second enzyme is overexpressed in the genetically modified organism in an amount to achieve a phosphoribulokinase activity level that is higher than the native phosphoribulokinase activity level of the organism, and the second enzyme utilizes ribulose-5-phosphate to produce ribulose-1,5-bisphosphate;
wherein the first acetyl phosphate product is converted in the organism to acetyl-CoA;
wherein the genetically modified organism fixes two CO2 molecules onto two of the ribulose-1,5-bisphosphate molecules, and the reaction products are then turned over in the CBB cycle to produce one acetyl-CoA molecule from the first acetyl phosphate, when the organism is grown in culture at ammonium levels of less than 3 mM; and
wherein the production of phosphoenolpyruvate (PEP) in the genetically modified organism, when grown under nitrogen depletion, is below a feedback inhibitory concentration for the CBB cycle.

US Pat. No. 10,113,152

VARIANT POLYPEPTIDES CAPABLE OF AMINATING ALIPHATIC ALPHA KETO ACIDS

AbbVie Inc., North Chica...

1. A polypeptide, comprising:(a) the amino acid sequence of any one of SEQ ID NOS:2 and 13-18, wherein X is not leucine;
(b) an amino acid sequence that is at least 95% identical to: (i) amino acids 6 to 238 of SEQ ID NO:2; (ii) amino acids 7 to 237 of SEQ ID NO:13; (iii) amino acids 4 to 236 of SEQ ID NO:14; (iv) amino acids 4 to 236 of SEQ ID NO:15; (v) amino acids 4 to 236 of SEQ ID NO:16; (vi) amino acids 4 to 236 of SEQ ID NO:17; or (vii) amino acids 4 to 236 of SEQ ID NO:18, wherein X is not leucine;
(c) an amino acid sequence that is at least 95% identical to: (i) amino acids 6 to 298 of SEQ ID NO:2; (ii) amino acids 7 to 297 of SEQ ID NO:13; (iii) amino acids 4 to 296 of SEQ ID NO:14; (iv) amino acids 4 to 296 of SEQ ID NO:15; (v) amino acids 4 to 296 of SEQ ID NO:16; (vi) amino acids 4 to 296 of SEQ ID NO:17; or (vii) amino acids 4 to 296 of SEQ ID NO:18, wherein X is not leucine; or
(d) the amino acid sequence of SEQ ID NO: 4, 5, 6, or 20;
wherein the polypeptide is isolated and wherein the polypeptide has the ability to convert 2-oxonon-8-enoic acid, in the presence of an ammonia source, to 2-aminonon-8-enoic acid; and
X is isoleucine, valine, glycine, alanine, serine, or threonine.

US Pat. No. 10,113,145

PAENIBACILLUS SP. STRAIN, CULTIVATION METHOD AND USE OF THE SAME

1. An extracellular polysaccharide of Paenibacillus, wherein the structural formula of the extracellular polysaccharide shown in Formula (1),
wherein, n=15-30;
wherein the extracellular polysaccharide is purified and free of non-carbohydrate structure including protein, sulfide and amidogen;
wherein the extracellular polysaccharide has an average molecular weight distribution of 2500 to 5000 Da; and/or has following appearance: pure white filament or powder; wherein the extracellular polysaccharide is produced by Paenibacillus bovis sp. nov. BD3526 whose deposit number is CGMCC No. 8333.

US Pat. No. 10,113,143

CELL CULTURE BAG AND METHOD FOR MANUFACTURING CELL CULTURE BAG

Yokogawa Electric Corpora...

1. A cell culture bag comprising:an external film;
at least one sensor chip arranged on an inner surface of the external film, the at least one sensor chip including a layer reacting to an object to be detected, the inner surface being on a culture fluid side of the external film; and
a permeable film that covers a culture fluid side of the sensor chip, the permeable film permeating the object to be detected,
wherein the permeable film covers the entire inner surface of the external film,
wherein the at least one sensor chip comprises a plurality of sensor chips arranged into a plurality of groups,
wherein a group of sensor chips having the largest size is arranged at the center of the plurality of groups, the remaining groups of sensor chips having a smaller size being arranged around the group of sensor chips having the largest size, and
wherein the group of sensor chips having the largest size is configured to generate a stronger signal than the remaining groups of sensor chips having a smaller size.

US Pat. No. 10,113,142

METHOD AND APPARATUS FOR MAKING SOAP

DESIGNED BY M.E., LLC, B...

1. A method for making soap comprising:piercing, upon closure of a lid of an apparatus, a lye capsule in a lye container;
combining, in a first mixing vessel, a portion of water from a water vessel with a portion of lye from the lye capsule to form a first mixture;
cooling, in the first mixing vessel, the first mixture to a first predetermined temperature;
combining, in an oil vessel, two or more oils to dissolve into a second mixture;
heating, in the oil vessel, the second mixture to a second predetermined temperature to produce a heated second mixture;
adding, in the oil vessel, a third oil to the heated second mixture;
cooling, in the oil vessel, the heated second mixture to a third predetermined temperature to produce a cooled second mixture;
combining, in a second mixing vessel, the first mixture and the cooled second mixture to form a third mixture; and
discharging the third mixture from the second mixing vessel into one or more soap molds to form one or more bars of soap.

US Pat. No. 10,113,141

CLEANING LIQUID FOR SEMICONDUCTOR DEVICE AND METHOD FOR CLEANING SUBSTRATE FOR SEMICONDUCTOR DEVICE

MITSUBISHI CHEMICAL CORPO...

1. A cleaning liquid for a semiconductor device, comprising the following components (1)? to (4)?:(1)? an inorganic alkali;
(2)? a carboxyl group-containing chelating agent, which is at least one amino acid selected from the group consisting of cysteine and histidine;
(3)? an anionic surfactant which is at least one of a benzenesulfonic acid substituted with an alkyl group having from 8 to 20 carbon atoms and a salt thereof; and
(4)? water,
wherein the cleaning liquid has a pH of 9 or more.

US Pat. No. 10,113,136

FRACTIONATION OF FRANKINCENSE RESIN USING SUPERCRITICAL CARBON DIOXIDE

PHYTOVATION LTD, Gwynedd...

1. A method for sequentially extracting essential oil, incensole derivatives and boswellic acid from frankincense resin, said method comprising:a) grinding the frankincense resin;
b) separating a first fraction of essential oil with liquid carbon dioxide at a first temperature ranging between 0° C. and 30° C. and a first pressure ranging between 40 bars and 73.8 bars or with mild supercritical carbon dioxide, and with a first flow rate ranging between 10 g and 400 g/kg ground material/min until no further essential oil can be recovered or the extract yield falls below 0.1% of starting mass per hour;
c) retrieving essential oil from the separator;
d) separating a second fraction of incensole derivatives with supercritical carbon dioxide at a second temperature ranging between 31° C. and 100° C. and a second pressure of at least 72.8 bars and a second flow rate ranging between 10 g and 400 g/kg ground material/min until no further incensole or its derivatives can be recovered or the extract yield falls below 0.1% of starting mass per hour;
e) retrieving incensole derivatives from the separator;
f) optionally, continuing the separation process with supercritical carbon dioxide at other sets of increasing temperature and/or pressure until further desired fractions are separated;
g) separating a further fraction of boswellic acid with supercritical carbon dioxide at a temperature of at least 31° C. and a pressure of at least 72.8 bars and a flow rate ranging between 10 g and 400 g/kg ground material/min using a co-solvent at a level ranging between 0.05 vol % and 50.0 vol % of the CO2 flowrate until complete separation of boswellic acids is achieved or it is determined that no further materials can be extracted or the extract yield falls below 0.1% of starting mass per hour;
h) retrieving boswellic acid from the separator and removing the co-solvent by evaporation or distillation;
i) optionally, continuing the separation process with supercritical carbon dioxide at another set of temperature and pressure and co-solvent until all desired fractions are separated; and
j) retrieving the remaining unseparated residues.

US Pat. No. 10,113,133

RANDOM COPOLYMERS OF ACRYLATES AS POLYMERIC FRICTION MODIFIERS, AND LUBRICANTS CONTAINING SAME

AFTON CHEMICAL CORPORATIO...

1. A random copolymer obtained from polymerizing an acrylate monomer composition, wherein the monomer composition comprises:a) from about 5 to about 55 mole % of at least one short chain acrylate of Formula (I),
in which Ra is hydrogen or methyl, and R1 is a linear or branched C1 to C10 alkyl radical;b) from about 0 to less than about 75 mole % of at least one long chain acrylate of Formula (II),
in which Rb is hydrogen or methyl, and R2 is a linear or branched C11 to C15 alkyl radical;c) from about 0 to less than about 75 mole % of at least one long chain acrylate of Formula (III),
in which Rc is hydrogen or methyl, and R3 is a linear or branched C16 to C30 alkyl radical; andd) from about 5 to about 50 mole % of at least one polar acrylate of Formula (IV),
in which Rd is hydrogen or methyl, A is a linear or branched C2 to C6 alkyl radical, aromatic radical, or a polyether of the formula (—CHR4CH2—O—)n where R4 is hydrogen or methyl and n is from 1 to 10; and X is COOH or OH;wherein,at least one of Ra , Rb , Rc , and Rd is methyl;
the long chain acrylate of component b) and component c) together total from about 35 mole % to about 75 mole % of the acrylate monomers;
the ratio of short chain acrylate to long chain acrylate is from about 0.05 to about 2; and
the copolymer has an Mn of 1000 to 8000 g/mol.

US Pat. No. 10,113,131

PHOSPHONO PARAFFINS

THE BOEING COMPANY, Chic...

1. A phosphono paraffin represented by formula (I):
wherein:
each instance of R1 is independently —H or

each instance of R2 and R3 is independently C1-20 alkyl, cycloalkyl of C20 or less, or aryl;
n is an integer between 4 and 22;
and the number of instances where R1 is
of formula (I) is between about 2 and about 8.

US Pat. No. 10,113,130

HIGH DENSITY/HIGH CETANE RENEWABLE FUEL BLENDS

The United States of Amer...

1. A method for making a diesel fuel blend or a jet fuel blend, comprising:(i) cycloaddition of renewable alkenes, ketones, or aldehydes to prepare multicyclic alkanes or multicyclic alkenes, (ii) converting norbornadiene to multicyclic alkanes or multicyclic alkenes, (iii) converting cyclopentadiene or a functionalized cyclopentadiene to multicyclic alkanes or multicyclic alkenes, or (iv) converting cyclooctatetraene to multicyclic alkanes or multicyclic alkenes;
preparing a synthetic paraffinic kerosene and mixing said synthetic paraffinic kerosene with the multicyclic alkanes or multicyclic alkenes prepared by one of steps (i)-(iv) to produce said deisel fuel blend with a cetane number>40 or said jet fuel blend with a viscosity below 8.5 cSt at ?20° C.

US Pat. No. 10,113,129

APPARATUS FOR CONDUCTING A HYDROTHERMAL CARBONIZATION REACTION

AVA Green Chemistry Devel...

1. An apparatus for conducting a hydrothermal carbonization reaction comprising:(a) a steam generator;
(b) a mixing tank;
(c) a buffer tank; and
(d) a reaction tank connected with the steam generator to receive hot steam and connected with the mixing tank by way of a feed pipe to receive biomass and connected with the buffer tank to drain off a slurry formed in the reaction tank from the hot steam and the biomass;
wherein the mixing tank is structured as a pulper and forms a closed heat circuit comprising a first heat exchanger for giving off heat to the biomass contained in the pulper and a second heat exchanger connected with the first heat exchanger and associated with the buffer tank for absorbing the heat from the slurry drained out of the reaction tank into the buffer tank;
wherein thermal oil is conducted in the heat circuit as a heat carrier;
wherein the at least one of the pulper and the buffer tank is surrounded by at least one heat exchanger coil or wherein at least one heat exchanger coil passes through the pulper or the buffer tank; and
wherein at least one third heat exchanger is associated with the heat circuit for withdrawing heat from the heat circuit or for feeding heat into the heat circuit in a targeted manner.

US Pat. No. 10,113,127

PROCESS FOR SEPARATING NITROGEN FROM A NATURAL GAS STREAM WITH NITROGEN STRIPPING IN THE PRODUCTION OF LIQUEFIED NATURAL GAS

1. A process for producing liquefied natural gas from a nitrogen-containing natural gas stream, the process comprising:a) cooling a stream of mixed refrigerant in a first heat exchanger of a single closed-loop mixed refrigerant system to provide a cooled mixed refrigerant stream;
b) expanding at least a portion of the cooled mixed refrigerant stream to produce an expanded mixed refrigerant stream;
c) cooling and at least partially condensing the natural gas stream in a first heat exchange passageway via indirect heat exchange with the expanded mixed refrigerant stream in the first heat exchanger to produce a cooled natural gas stream;
d) dividing the cooled natural gas stream withdrawn from the first heat exchange passageway into a first portion and a second portion;
e) introducing the first portion into a lower inlet of a first vapor-liquid separator;
f) subsequent to said dividing, subcooling the second portion in the first heat exchanger to provide a subcooled liquid portion, wherein said subcooling is carried out in a second heat exchange passageway via indirect heat exchange with said expanded mixed refrigerant;
g) subsequent to said subcooling, introducing the subcooled liquid portion into an upper inlet of the first vapor-liquid separator, wherein the upper inlet of the first vapor-liquid separator is located at a higher vertical elevation than the lower inlet;
h) withdrawing a methane rich liquid bottoms stream and a first nitrogen rich vapor overhead stream from the first vapor-liquid separator;
i) further cooling the methane rich liquid bottoms stream in the first heat exchanger in a third heat exchange passageway to provide a first liquid natural gas stream;
j) introducing at least a portion of the first liquid natural gas stream into an inlet of a nitrogen stripping column;
k) introducing at least a portion of the first nitrogen rich vapor overhead stream into another inlet of the nitrogen stripping column;
l) withdrawing a stream of nitrogen-depleted liquefied natural gas (LNG) from a lower portion of the nitrogen stripping column, wherein the LNG comprises less than 3 volume percent nitrogen;
m) recovering an overhead nitrogen rich vapor stream from a location near the top of the nitrogen stripping column, wherein the overhead nitrogen rich vapor stream comprises less than 3 volume percent methane;
n) introducing the overhead nitrogen rich vapor stream into the first heat exchanger; and
o) using at least a portion of the overhead nitrogen rich vapor stream as a refrigerant in the first heat exchanger to carry out at least a portion of the cooling of step (a) and/or at least a portion of the cooling of step (c), wherein the single closed-loop mixed refrigerant system is the only closed-loop refrigeration system used to cool the natural gas stream.

US Pat. No. 10,113,126

REUSABLE POLYMERIC MATERIAL FOR REMOVING SILOXANE COMPOUNDS IN BIOGAS, METHOD THEREBY AND APPARATUS THEREFOR

KOREA INSTITUTE OF SCIENC...

1. A polyacrylate-based polymer absorbent for removing siloxane compounds from biogas, comprising:particles of poly(meth)acrylate salt, cations of the salt being other than sodium;
hygroscopic inorganic particles, anions of the inorganic particles selected from the group consisting of chloride, bromide and iodide, cations of the inorganic particles including sodium; and
a porous support.

US Pat. No. 10,113,124

CONTROL UNIT FOR GASIFICATION POWER GENERATION PLANT, GASIFICATION POWER GENERATION PLANT, AND CONTROL METHOD FOR GASIFICATION POWER GENERATION PLANT

MITSUBISHI HITACHI POWER ...

1. A control unit for a gasification power generation plant including a gasifier that gasifies carbon-containing fuel by using an oxidizer, a gas turbine that is driven by combustion gas generated by combustion of fuel gas obtained by purifying synthesis gas from the gasifier in gas clean-up equipment, and an oxidizer supply path for supplying air extracted from an air compressor of the gas turbine or oxygen separated from the air as an oxidizer for the gasifier,the control unit for the gasification power generation plant comprising a switching unit for choosing a fixed-air-ratio mode, in which an air ratio representing the ratio of the amount of the oxidizer that is supplied to the gasifier relative to a theoretical amount of the oxidizer for combustion of the carbon-containing fuel is fixed, in a case where the gasification power generation plant is in a stable state, whereas choosing a variable-air-ratio mode, in which the air ratio is variable by varying an oxidizer amount in accordance with a load of the gasification power generation plant so that the air ratio is decreased, in a case where an operating-state quantity of the gasifier has varied or in a case where the load of the gasification power generation plant has varied.

US Pat. No. 10,113,123

PROCESS AND SYSTEM FOR EXTRACTION OF A FEEDSTOCK

1. A system for recovering aromatics from a naphtha feedstock, comprising:(a) a naphtha splitter for separating a C6+ fraction from the naphtha feedstock;
(b) a hydrotreater unit to desulphurize and separate a C6 to C11 hydrocarbon fraction from the C6+ fraction;
(c) an aromatics extraction distillation unit for recovering from the C6 to C11 hydrocarbon fraction an aromatics fraction, an aromatics precursors fraction and a raffinate fraction;
(d) a dehydrogenation unit or a reformer for converting the aromatics precursors in the aromatics precursors fraction to aromatics; and
wherein the naphtha splitter, the hydrotreater unit, and the aromatic extraction distillation unit, are operatively connected such that the C6+ fraction and the C0 to C11 hydrocarbon fraction are not subjected to a reformer or a dehydrogenation unit prior to the recovery of the aromatics fraction, the aromatics precursors fraction and the raffinate fraction.

US Pat. No. 10,113,122

PROCESS FOR UPGRADING HEAVY HYDROCARBON LIQUIDS

UNIVERSITY OF NEW BRUNSWI...

1. A hydrogen-free process for upgrading heavy hydrocarbon liquids, comprising:a) mixing a pre-heated heavy hydrocarbon liquid feedstock with glycerol and a catalyst to form a mixture, wherein the mixture has a heavy hydrocarbon liquid feedstock to glycerol weight ratio from about 5000:1 to about 100:10 and a heavy hydrocarbon liquid feedstock to catalyst weight ratio from about 5000:1 to about 100:10;
b) feeding the mixture into a first reactor comprising propellers, heated up to a temperature in a range from about 200° C. to about 450° C. to partially treat the mixture, maintaining a pressure in the first reactor in a range from about 0.6 MPa to about 0 MPa absolute, and driving said propellers to apply shear forces to the mixture in a range from about 300 N/m2 to about 10000 N/m2;
c) after a preselected period of time, flowing the partially treated mixture to a second reactor having a holding volume larger than the first reactor, heated up to a temperature in a range from about 250° C. to about 380° C. and maintaining a pressure in the second reactor in a range from about 0.6 MPa to about 0 MPa absolute to further treat the partially treated mixture, said second reactor having a bottom with a bottom exit port and top exit port such that first hydrocarbon fractions are separated from second hydrocarbon fractions, wherein the first hydrocarbon fractions have a boiling point higher the second hydrocarbon fractions, and the second hydrocarbon fractions are vaporized and flow up through the top exit and collected into a distillation column, and said first hydrocarbon fractions sink to the bottom of the second reactor and are flowed out through the bottom exit port and recirculated back to the first reactor; and
d) collecting an upper portion of the second hydrocarbon fractions separated from a lower portion of the second hydrocarbon fractions in the distillation column out through an upper exit port and storing the collected upper portion of the second hydrocarbon fractions, and collecting the lower portion of the second hydrocarbon fractions out through a lower exit port and storing the collected lower portion of the second hydrocarbon fractions, wherein the upper portion of the second hydrocarbon fractions has a boiling point lower than the lower portion of the second hydrocarbon fractions, wherein the process is carried out with no external hydrogen gas.

US Pat. No. 10,113,121

GASOLINE PRODUCTION PROCESS COMPRISING AN ISOMERIZATION STEP FOLLOWED BY AT LEAST TWO SEPARATION STEPS

AXENS, Rueil Malmaison (...

1. A process for the isomerization of a light naphtha, said process comprising an isomerization reaction step (1), said step being carried out under the following conditions:a temperature in the range 100° C. to 300° C.,
a pressure of 2 to 35 bar (1 bar=0.1 MPa), and
a molar ratio of hydrogen/hydrocarbons in the range 0.1/1 to 1/1,
a space velocity of 0.5 to 10 h?1,
the catalysts used being constituted by a support of high purity alumina comprising 2% to 10% by weight of chlorine, 0.1% to 0.40% by weight of platinum, and optional other metals, said isomerization step being followed by a step (2) for stabilization of the reaction effluents, and by two steps for separation by distillation of the bottom stream obtained from the stabilization step (2) which are placed downstream of the stabilization step (2), the two separation steps being as follows:
1—a first step for separation by distillation (block (3+4) in order to separate the hydrocarbons containing 5 carbon atoms from heavier compounds sent towards the second section for distillation by separation (5), said first separation step producing the following 3 cuts: a) a cut which is enriched in isopentane (15) which is a product of the process, b) a cut which is enriched in n-pentane (16) which is recycled to the reaction section (1), and c) a cut which is enriched in hydrocarbons which are heavier than pentanes (17), which is directed towards a second separation step (5), (5), consisting of a separation column wherein the overhead stream (19) which is rich in C6 branched compounds and bottom stream (18), are the products from the unit and an intermediate cut (20) which is enriched in n-hexane, removed as a side stream which is recycled to the reaction section (1), in which in an isomerization process an exchange of heat is carried out between a condenser of one of the columns (3), (4) or (5) and the reboiler of one of columns (3), (4) or (5).

US Pat. No. 10,113,119

THERMALLY STABLE MONOLITH CATALYST FOR REFORMING REACTION

KOREA RESEARCH INSTITUTE ...

1. A thermally stable monolith catalyst for reforming reaction, comprising:an active ingredient and Group 1A to 5A metal of barrier components represented by Formula 1 below on a monolith catalyst support, wherein the active ingredient of Formula 1 has 0.5 to 10 parts by weight based on 100 parts by weight of a monolith catalyst,
a(X)-b(Y)  Formula 1
wherein X is a catalytic active ingredient selected from Co, Ni, Ru, Rh and a mixture thereof, Y is a mixture of Zr as a promoter and Group 1A to 5A metals as a barrier component in a mixing ratio by weight of 1:0.1 to 1:10, and ‘a’ and ‘b’ denote the ratios by weight of X and Yin order, wherein ‘a’ is 1 and ‘b’ ranges from 0.2 to 1.5.

US Pat. No. 10,113,118

PROCESS AND APPARATUS FOR PRODUCING HYDROCARBON

1. Method for producing liquid hydrocarbon by converting carbonaceous material contained in one or more feedstocks, the method comprisingProviding a feed material;
Pressurizing the feed material to a predetermined process pressure of 150 to 400 bar;
Heating the pressurized feed material to a predetermined process temperature of 370 to 500° C.;
Reacting the pressurized and heated feed material for a predetermined period of time;
Cooling the reacted feed material to a temperature below 200° C.;
Mechanically separating the converted feed material at operational pressure into a higher viscosity fraction and a lower viscosity fraction, and extracting the higher viscosity fraction from the process through alternating mechanical filters between at least one online filter and at least one offline filter, the temperature of the filters being controlled to be in the range 40 to 200° C.; and
Conveying the remaining converted feed mass including the lower viscosity fraction through a pressure reduction system and further through a separation system.

US Pat. No. 10,113,117

VERTICAL ALIGNMENT LIQUID CRYSTAL DISPLAY AND MANUFACTURE METHOD THEREOF

Shenzhen China Star Optoe...

1. A manufacture method of a vertical alignment liquid crystal display, comprising steps of:step 1, loading a first substrate and a second substrate;
wherein a first passivation layer and a second passivation layer are respectively located on inner sides of the first substrate and the second substrate, and a common electrode layer and a pixel electrode layer are respectively located on the first passivation layer and the second passivation layer;
step 2, coating a glue frame on the first substrate or the second substrate;
step 3, filling a liquid crystal layer in a district surrounded by the glue frame;
wherein the liquid crystal layer comprises liquid crystal molecules, auxiliary alignment agent and polymeric monomers; and
a weight percentage of the polymeric monomers in the liquid crystal layer is 0.5%-0.8%;
step 4, assembling the first substrate and the second substrate; and
step 5, applying a voltage to the common electrode layer and the pixel electrode layer to make the liquid crystal molecules of the liquid crystal layer twisted with a predetermined degree, and employing ultraviolet (UV) light to irradiate the liquid crystal layer;
wherein the polymeric monomers are polymerized to form a polymer network penetrating the entire liquid crystal layer; and
wherein each of the polymeric monomers has at least two polymerizable groups;
wherein the polymeric monomers comprise at least one double polymerizable group monomer having two polymerizable groups and at least one polymeric group compound having at least three polymerizable groups; and a weight percentage of the polymeric group compound in the polymerizable monomers is 10%-50%.

US Pat. No. 10,113,115

NEMATIC LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE USING THE SAME

DIC CORPORATION (TOKYO), ...

1. A liquid crystal composition having a negative dielectric anisotropy, the composition comprising a first component that is at least one compound represented by General Formula (i)(where Ri1 represents an alkyl group having 1 to 8 carbon atoms, and Ri2 represents an alkyl group having 3 to 8 carbon atoms) anda second component that is at least e compound selected from compounds represented by General Formula (L)(where RL1 and RL2 each independently represent an alkyl group having 1 to 8 carbon atoms; in the alkyl group, one —CH2— or at least two —CH2-'s not adjoining each other are each independently optionally substituted with —CH?CH—, —C?C—, —O—, —CO—, —COO—, or —OCO—;nL1 represents 0, 1, 2, or 3;
AL1, AL2, and AL3 each independently represent a group selected from the group consisting of(a) a 1,4-cyclohexylene group (in which one —CH2— or at least two —CH2—'s not adjoining each other are each optionally substituted with —O—),(b) a 1,4-phenylene group (in which one —CH? or at least two —CH?'s not adjoining each other are each optionally substituted with —N?), and(c) a naphthalene-2,6-diyl group, a 1,2,3,4-tetrahydronaphthalene-2,6-diyl group, or a decahydronaphthalene-2,6-diyl group (in the naphthalene-2,6-diyl group or the 1,2,3,4-tetrahydronaphthalene-2,6-diyl group, one —CH? or at least two —CH?'s not adjoining each other are each optionally substituted with —N?);the groups (a) to (c) are each independently optionally substituted with a cyano group, a fluorine atom, or a chlorine atom;ZL1 and ZL2 each independently represent a single bond, —CH2CH2—, —(CH2)4—, —OCH2—, —CH2O—, —COO—, —OCO—, —OCF2—, —CF2O—, —CH?N—N?CH—, —CH?CH—, —CF?CF—, or —C?C—;
in the case where nL1 is 2 or 3 and where AL2 is multiple, the multiple AL2's may be the same as or different from each other; in the case where nL1 is 2 or 3 and where ZL3 is multiple, the multiple ZL3's may be the same as or different from each other; and the compound represented by General Formula (L) excludes the compound represented by General Formula (i)).

US Pat. No. 10,113,113

REMOVING POLYSILICON

Micron Technology, Inc., ...

1. A method, comprising:forming a first instance of oxide;
forming an instance of polysilicon over the instance of oxide;
forming a second instance of oxide over the instance of polysilicon;
forming an opening through the second instance of oxide, the instance of polysilicon and the first instance of oxide;
exposing the second instance of oxide, the instance of polysilicon and the first instance of oxide to an aqueous composition; and
using the aqueous composition, recessing the instance of polysilicon relative to the first instance of oxide and the second instance of oxide within the opening;
wherein the aqueous composition comprises nitric acid, poly-carboxylic acid and ammonium fluoride.

US Pat. No. 10,113,110

BORON-LOADED LIQUID SCINTILLATOR COMPOSITIONS AND METHODS OF PREPARATION THEREOF

ATOMIC ENERGY OF CANADA L...

1. A boron-loaded liquid scintillator composition comprising: linear alkylbenzene (LAB), a carborane, 2,5-diphenyloxazole (PPO) and 1,4-bis[2-methylstyryl]benzene (bis-MSB) as a wavelength shifter, the LAB, carborane, PPO and bis-MSB being at concentrations at which the boron-loaded liquid scintillator composition enables detection of neutron signals while discriminating the neutron signals from gamma and beta radiation, the PPO at a concentration of 2-6 g/L and the bis-MSB at a concentration of 20-40 mg/L.

US Pat. No. 10,113,106

STRENGTH-ENHANCING RESIN FOR PROPPANT

Halliburton Energy Servic...

1. A method of fracturing a subterranean formation comprising:introducing a fracturing fluid into the subterranean formation, wherein the fracturing fluid comprises:
(A) a base fluid;
(B) proppant; and
(C) a curable resin having three or more epoxy functional group, wherein the curable resin is selected from the group consisting of trimethylolpropane trialycidyl ether, glycerol trialycidyl ether, pentaerythritol tetraalycidyl ether, glycerol polyethylene oxide trialycidyl ether, glycerol polypropylene oxide trialycidyl ether, polyalycerol-3-polyalycidyl ether, polyalycerol-3-olyethylene oxide polyalycidyl ether, polyalycerol-3-polypropylene oxide polyalycidyl ether, and combinations thereof;
wherein the curable resin is pre-coated onto the proppant prior to introduction into the subterranean formation;
creating or enhancing one or more fractures within the subterranean formation using the fracturing fluid;
then introducing a curing agent into the subterranean formation; and
allowing or causing to allow the curing agent to contact the curable resin in the subterranean formation; wherein the curable resin does not substantially cure prior to contacting the curing agent; wherein the curable resin cures when in contact with the curing agent; wherein the curable resin forms polymer molecules with the curing agent, and wherein the polymer molecules are non-linear or multi-directional polymers; wherein at least some of the three or more epoxy functional groups cross-link the polymer molecules together; wherein the curable resin and the curing agent form a multi-directional, cross-linked polymer network; and
wherein the cured resin increases the compressive strength of the proppant, wherein the compressive strength of the proppant is increased to a strength of at least 5,000 pounds force per square inch.

US Pat. No. 10,113,104

SUPERHYDROPHIC FLOW CONTROL DEVICE

Halliburton Energy Servic...

1. A wellbore subassembly, comprising:a flow control device having a helical enclosed production flow path toward a production tubing, the helical enclosed production flow path being positioned circumferentially about the production tubing, wherein the helical enclosed production flow path includes a superhydrophobic coating on an inner surface of the helical enclosed production flow path for restricting production of an unwanted fluid toward the production tubing, the superhydrophobic coating having a contact angle with a water droplet in the unwanted fluid that exceeds 150°, and wherein the superhydrophobic coating is operable for increasing a velocity of fluid having a greater concentration of oil flowing along the production flow path, wherein the inner surface of the helical enclosed production flow path has a plurality of protrusions.

US Pat. No. 10,113,102

ACTIVITY ENHANCED SCALE DISPERSANT FOR TREATING INORGANIC SULFIDE SCALES

Multi-Chem Group, LLC, S...

14. A composition comprising:a base fluid;
a scale inhibitor, wherein the scale inhibitor comprises a phosphonate;
a water clarifying agent, wherein the water clarifying agent comprises at least one compound selected from the group consisting of: a polyDADMAC, a DADMAC acrylamide copolymer, and any combination thereof; and
a sulfide precipitate.

US Pat. No. 10,113,101

COMPOSITION AND METHOD FOR DISPERSING PARAFFINS IN CRUDE OILS

Ecolab USA Inc., St. Pau...

1. A method for reducing paraffin or wax deposition in a crude oil storage or transportation vessel, the method comprising adding a composition to a crude oil in an amount effective to reduce paraffin or wax deposition in the storage or transportation vessel containing the crude oil, wherein the crude oil has an API gravity of at least 33 and the composition comprisesa copolymer which is a product of a polymerization reaction comprising (i) an alpha olefin monomer and a maleic anhydride monomer, (ii) the alpha olefin monomer and an alkyl maleic anhydride monomer, (iii) the maleic anhydride monomer and styrene; or (iv) the alkyl maleic anhydride monomer and styrene, the alpha olefin monomer having the formula (I):
wherein R1 is hydrogen or C12-C30 alkyl and R2 is C12-C30 alkyl, and the alkyl maleic anhydride monomer having the formula (II):wherein R3 is C12-C30 alkyl and R4 is hydrogen or C12-C30 alkyl;an anionic surfactant; and
a solvent; and
wherein if the copolymer is the product of the polymerization reaction comprising (i) the alpha olefin monomer and the maleic anhydride monomer, R1 is hydrogen and R2 is C24-C30 alkyl.

US Pat. No. 10,113,100

COMPOSITIONS WITH POLYAZIRIDINE CROSSLINKERS FOR TREATING SUBTERRANEAN FORMATIONS

Saudi Arabia Oil Company,...

1. A method of treating a subterranean formation comprising:i) providing to a subterranean formation a composition comprising:a maleic anhydride copolymer, or a salt thereof; andat least one hydrolyzed repeat unit selected from repeat units III and IV:

or a salt thereof, wherein each R5 is independently selected from —OH and NH2, provided that at least one of R5 is NH2, anda polyaziridine crosslinker having the formula:or a salt thereof, wherein:L1 and L2 at each occurrence are each independently selected from the group consisting of —C1-6 alkylene-, —C1-6 alkenylene-, —C1-6 alkynylene-, —(O—C1-4 alkylene)p-, —(C1-4 alkylene-O—)p—, —O—, —S—, NH—, and —C(?O)—, wherein said —C1-6 alkylene-, —C1-6 alkenylene-, —C1-6 alkynylene-, and —C1-4 alkylene- are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of -halo, —CN, —OH, —C1-3 alkyl, —C1-3 alkoxy, —C1-3 haloalkyl, —C1-3 haloalkoxy, -amino, —C1-3 alkylamino, and -di(C1-3 alkyl)amino;
each R3 is selected from the group consisting of —H, —C1-6 alkyl, —C1-6 alkenyl, —C1-6 alkynyl, -halo, —CN, —OH, —C1-3 alkoxy, —C1-3 haloalkyl, —C1-3 haloalkoxy, -amino, —C1-3 alkylamino, -di(C1-3 alkyl)amino, —(O—C1-4 alkylene)p-H, and (C1-4 alkylene-O—)p—C1-6 alkyl;
each R4 is selected from the group consisting of:

 wherein each of (a) and (b) is optionally substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of halo, CN, OH, amino, C1-3 alkylamino, di(C1-3 alkyl)amino, —C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy;
p at each occurrence is independently an integer from 0 to 40;
x and y at each occurrence are each independently an integer from 0 to 10;
m is an integer from 2 to 4; and
n is an integer from 0 to 4;
provided that the sum of m and n is 4; and
ii) crosslinking the maleic anhydride copolymer, or a salt thereof, and the polyaziridine crosslinker, or a salt thereof, to form a sealant.

US Pat. No. 10,113,098

COMPOSITION INCLUDING VISCOSIFIER POLYMER AND POLYAMINE VISCOSITY MODIFIER FOR TREATMENT OF SUBTERRANEAN FORMATIONS

Halliburton Energy Serviv...

1. A composition for treatment of a subterranean formation, the composition comprising:a viscosifier polymer comprising
an ethylene repeating unit comprising an —NRa—C(O)—Rb group, wherein at each occurrence Ra and Rb are each independently selected from —H and substituted or unsubstituted (C1-C20)hydrocarbyl or Ra and Rb together form a substituted or unsubstituted (C2-C20)hydrocarbylene,
an ethylene repeating unit comprising an —S(O)2OR1 group wherein at each occurrence R1 is independently selected from —H, substituted or unsubstituted (C1-C20)hydrocarbyl, and a counterion,
at least one crosslinker repeating unit comprising an ethylene repeating unit at each occurrence independently linked to an ethylene repeating unit in the same viscosifier polymer molecule or in another molecule of the viscosifier polymer via a substituted or unsubstituted (C1-C40)hydrocarbylene interrupted by 0, 1, 2, or 3 groups independently chosen from —O—, —S—, and substituted or unsubstituted —NH—,
wherein the repeating units are in block, alternate, or random configuration; and
a polyamine viscosity modifier, wherein the polyamine viscosity modifier is present in the composition in an amount of about 0.01 wt % to about 5 wt %, wherein the polyamine viscosity modifier reduces the viscosity of the composition such that the composition comprising the polyamine viscosity modifier has a lower viscosity than an equivalent composition without the polyamine viscosity modifier.

US Pat. No. 10,113,086

EXPANDABLE TAPE

1. A hanging system in a room of a building comprising:at least one of a wall and a ceiling;
a sheet; and
wherein a first side of the sheet is connected to the at least one of the wall and the ceiling by a first widthwise expandable tape and a second widthwise expandable tape, wherein the first widthwise expandable tape is spaced apart from the second widthwise expandable tape, each of the first widthwise expandable tape and second widthwise expandable tape comprising:
a first adhesive strip defining one lengthwise edge of the widthwise expandable tape;
a second adhesive strip defining the other lengthwise edge of the widthwise expandable tape;
a flexible region connecting the first adhesive strip to the second adhesive strip, the flexible region adapted to lengthen and contract to allow a movement of the second adhesive strip away from and towards the first adhesive strip in a widthwise direction of the widthwise expandable tape upon an application of a force to at least one of the first adhesive strip and the second adhesive strip;
wherein the first widthwise expandable tape comprises a first quantity of adhesive on a bottom face of the first adhesive strip, and comprises a second quantity of adhesive disposed on a bottom face of the second adhesive strip, the bottom face of the second adhesive strip facing a same direction as the bottom face of the first adhesive strip.

US Pat. No. 10,113,084

MOLD RELEASE AGENT

Illinois Tool Works, Inc....

1. A mold release coating on a mold surface, the mold release coating being derived from a polysiloxane having the formula of formula 1:
where y?3 and x is ?0, where a reactive moiety for the purposes of the present invention include those moieties that react on the mold surface to form bonds to other polymers of Formula (I), the mold surface, or both, where reactive moieties comprise one or more of R4, R5, R6, or R7, where R4, R5, R6, or R7 are the same or different and each is independently one or more of reactive moieties of glycydoxy, C1-C8 alkoxy, C1-C8 alkoxy having a substituent, or independently one or more of unreactive moieties C1-C8 or longer alkyl, either branched or unbranched; and where R1 R2, R3, R8, R9, and R10 can be the same or different and each independently is a saturated C1-C8 or greater alkyl, either linear or branched with the proviso any hydrogen present in the R groups is non-labile; and
the mold surface being an inflatable elastomeric bladder surface, the polysiloxane bonded to the rubber bladder surface by reaction of the one or more reactive moieties.

US Pat. No. 10,113,083

RESIST UNDERLAYER FILM-FORMING COMPOSITION CONTAINING POLYMER WHICH CONTAINS NITROGEN-CONTAINING RING COMPOUND

NISSAN CHEMICAL INDUSTRIE...

1. A resist underlayer film-forming composition for lithography comprising a linear polymer that is obtained by a reaction of a diepoxy group-containing compound (A) with a dicarboxyl group-containing compound (B), wherein the linear polymer has structures of the following formulae (1), (2), and (3) derived from the diepoxy group-containing compound (A) or the dicarboxyl group-containing compound (B):
in Formula (1), X1 is a group of Formula (4), (5), or (6):

wherein each of R1, R2, R3, and R4 is a hydrogen atom, a C1-6 alkyl group, a C3-6 alkenyl group, benzyl group, or phenyl group, the phenyl group may be substituted by a group selected from the group consisting of a C1-6 alkyl group, a halogen atom, a C1-6 alkoxy group, a nitro group, a cyano group, a hydroxyl group, and a C1-6 alkylthio group, and R1 and R2 or R3 and R4 may be bonded to each other to form a C3-6 ring; and R5 is a C1-6 alkyl group, a C3-6 alkenyl group, benzyl group, or phenyl group, and the phenyl group may be substituted by a group selected from the group consisting of a C1-6 alkyl group, a halogen atom, a C1-6 alkoxy group, a nitro group; a cyano group, a hydroxyl group, and a C1-6 alkylthio group; and
Ar in Formula (2) is an aromatic C6-20 fused ring, and the ring may be substituted by a group selected from the group consisting of a C1-6 alkyl group, a halogen atom, a C1-6 alkoxy group, a nitro group, a cyano group, a hydroxyl group, and a C1-6 alkylthio group, wherein
the linear polymer is a polymer obtained by a reaction of two diepoxy group-containing compounds (A), one having the structure of Formula (1) and the other having the structure of Formula (2), with a dicarboxyl group-containing compound (B) having a structure of Formula (3); or
the linear polymer is a polymer obtained by a reaction of a diepoxy group-containing compound (A) having a structure of Formula (1) with two dicarboxyl group-containing compounds (B), one having the structure of Formula (2), and the other having the structure of Formula (3).

US Pat. No. 10,113,078

INK DISCHARGE DEVICE AND INK DISCHARGE METHOD

Ricoh Company, Ltd., Tok...

1. An ink discharge device comprising:an ink comprising:
water;
a colorant;
an organic solvent X having a solubility parameter of from 8.9 to 12.0, the organic solvent X comprising no glycol ether compound; and
a copolymer comprising a structural unit represented by the following formula (1):

where R1 represents a hydrogen atom or methyl group and Y represents an alkylene group having 2 to 18 carbon atoms;
an ink discharge head including:
a nozzle configured to discharge the ink;
a plurality of individual liquid chambers in communication with the nozzle;
a flow-in channel configured to let the ink flow into the individual liquid chambers; and
a flow-out channel configured to let the ink flow out from the individual liquid chambers; and
a negative pressure generator configured to generate a negative pressure that lets the ink flow out from the individual liquid chambers,
wherein the ink discharge head is configured to let the ink having flowed out from the flow-out channel flow into the flow-in channel to circulate the ink.

US Pat. No. 10,113,074

THERMALLY INKJETTABLE ACRYLIC DIELECTRIC INK FORMULATION AND PROCESS

FUNAI ELECTRIC CO., LTD.,...

1. An electronic device that comprises a dielectric layer, the dielectric layer being formed by one or more layers of an aqueous composition comprising:from about 5 to about 20 percent by weight of an acrylic polymeric binder emulsion;
from about 5 to about 30 percent by weight of a humectant;
from about 0 to about 3 percent by weight of a surfactant; and
an aqueous carrier fluid,
wherein the aqueous composition has a viscosity ranging from about 2 to about 6 centipoise,
wherein the dielectric layer has a thickness ranging from about 10 microns to about 40 microns, and
wherein the one or more layers have a glass transition temperature ranging from about 40° C. to about 110° C.

US Pat. No. 10,113,073

DIELECTRIC THICK FILM INK

GM GLOBAL TECHNOLOGY OPER...

1. A thermally conductive thick film dielectric ink for an electronic device, the thermally conductive thick film dielectric ink comprising a mixture of:an organic medium present in an amount from about 14.0 to about 32.0% by weight of the thick film dielectric ink, wherein the organic medium comprises 2,2,4-trimethyl-1,3-pentanediol present in an amount from about 81.0% to about 82.0% by weight of the organic medium, Diethylene Glycol Dibutyl Ether present in an amount from about 7.0% to about 11.0% by weight of the organic medium, Dodecyl Alcohol present in an amount about 2.0% by weight of the organic medium, Tridecyl Alcohol present in an amount from about 1.0% to about 4.0% by weight of the organic medium, and Ethyl Cellulose present in an amount from about 3.0 to about 6.5% by weight of the organic medium;
a glass binder; and
a technical ceramic powder having ceramic particles dispersed throughout the thermally conductive thick film dielectric ink mixture.

US Pat. No. 10,113,072

ELECTROPHORETIC PARTICLE, METHOD OF MANUFACTURING ELECTROPHORETIC PARTICLE, ELECTROPHORESIS DISPERSION LIQUID, ELECTROPHORESIS SHEET, ELECTROPHORESIS DEVICE, AND ELECTRONIC APPARATUS

E Ink Corporation, Bille...

1. An electrophoretic particle, comprising:a particle including a first functional group on a surface; and
a first compound, a second compound, and a third compound bonded to the particle,
wherein the first compound is a block copolymer that includes a dispersion portion derived from a first monomer including a site that contributes to dispersibility in a dispersion medium, and a bonding portion derived from a second monomer including a second functional group having reactivity with the first functional group, and is connected to the particle by reacting the functional group and the second functional group in the bonding portion,
the second compound has a lower molecular weight than the first compound, includes a non-polar group and the second functional group, and is connected to the particle by the second functional group reacting with the first functional group, and
the third compound has a lower molecular weight than the first compound, includes a charging group and the second functional group, and is connected to the particle by the second functional group reacting with the first functional group.

US Pat. No. 10,113,065

TWO-PHOTON ABSORBING COMPOUNDS AND METHODS OF MAKING SAME

1. A two-photon active compound having a structural formula:wherein A is an aromatic-heterocyclic ?-electron acceptor moiety that is connected to m number of diarylaminofluorene arms (m=1-3); in each diarylaminofluorene arms, R is selected from linear or branched alkyl chains having a general formula CnH2n+1, where n is in a range from 2 to 25; wherein R1, R2, and R3 are independently selected from the group consisting of H and C1-C5 alkyls; wherein R4 is selected from the group consisting of C1-C5 alkyls; and wherein R5 through R10 are independently selected from the group consisting of H, alkoxyls, alkyls, and aryls.

US Pat. No. 10,113,057

METHOD FOR FORMING A POLYETHYLENE NANOCOMPOSITE

King Fahd University of P...

1. A method for forming a high-density polyethylene nanocomposite by polymerizing a mixture of ethylene and a calcium zirconate nanofiller, comprising:adding a zirconocene catalyst, the calcium zirconate nanofiller and a solvent to a reactor;
mixing the zirconocene catalyst and the calcium zirconate nanofiller in the solvent;
injecting ethylene into the reactor until absorption of ethylene is no longer observed; followed by
adding a methylaluminoxane cocatalyst into the reactor to from a catalyst mixture; then
polymerizing the ethylene by pressurizing the reactor with ethylene and maintaining a pressure of 1-1.5 bar to form a polymerization mixture; and then
quenching the polymerization mixture with methanol to form the high-density polyethylene nanocomposite;
wherein the calcium zirconate nanofiller is dispersed in a polyethylene matrix of the high-density polyethylene nanocomposite, and
the calcium zirconate nanofiller is not a support material for the zirconocene catalyst.

US Pat. No. 10,113,053

ISOSORBIDE EPOXIDE DIESTERS, AND THE USE THEREOF AS A PLASTICIZER IN PVC COMPOSITIONS

ROQUETTE FRERES, Lestrem...

1. A compound of the following formula (I):

US Pat. No. 10,113,052

5H-FURAN-2-ONE DERIVATIVES STABILIZATION OF ORGANIC MATERIAL

BASF SE, Ludwigshafen (D...

1. A composition comprisinga) a polyolefin, a polyester polyol, or a polyurethane;
b) compound having a structure,

 and
c) an additive selected from the group consisting of a phosphite, a phosphonite, an acid scavenger, a phenolic antioxidant, and an aminic antioxidant.

US Pat. No. 10,113,051

EPOXY ESTOLIDE FATTY ACID ALKYL ESTERS USEFUL AS BIORENEWABLE PLASTICIZERS

Regents of the University...

1. A composition comprising epoxy estolide fatty acid alkyl esters derived from triacylglycerol oil having an unsaturation of greater than 80 IV, wherein the estolide is derived from an epoxy group.

US Pat. No. 10,113,049

THERMOPLASTIC RESIN COMPOSITION

NIPPON NYUKAZAI CO., LTD....

1. A method for improving a gloss retention property of a thermoplastic resin composition comprising the step of combining(a) a thermoplastic resin, where said thermoplastic resin is not an aromatic polycarbonate resin or a polyvinyl chloride resin, and
(b) as ionically bonded salt represented by the following Chemical Formula (1) or (2):

in the Chemical Formula (I) above, R1 represents a substituted or unsubstituted linear, branched, or cyclic alkyl group having from 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms where the aryl group is not substituted with an alkyl group, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms,
A is a linear or branched alkylene group having from 2 to 4 carbon atoms,
n represents an integer of 1 to 50,
Q1 represents at least one kind selected from the group consisting of a dimethylammonium ion, a trimethylammonium ion, a diethylammonium ion, a triethylammonium ion, a monopropylammonium ion, a dipropylammonium ion, a tripropylammonium ion, a monobutylammonium ion, a dibutylammonium ion, a tributylammonium ion, a monopentylammonium ion, a dipentylaminoammonium ion, a tripentylammonium ion, a monohexylammonium ion, a dihexylammonium ion, a monoheptylammonium ion, a diheptylammonium ion, a monooctylammonium ion, a dioctylammonium ion, a monononylammonium ion, a monodecylammonium ion, a monoundecylammonium ion, a monododecylammonium ion, a monotridecylammonium ion, a monotetradecylammonium ion, a monopentadecylammonium ion, a monohexadecylammonium ion, a monoheptadecylammonium ion, a monooctadecylammonium ion, a monononadecylammonium ion, a monoicosylammonium ion, a monohenicosylammonium ion, a monodocosylammonium ion, a monotricocylammonium ion, a methyl(ethyl)ammonium ion, a methyl(propyl)ammonium ion, a methyl(butyl)ammonium ion, a methyl(pentyl)ammonium ion, a methyl(hexyl)ammonium ion, a methyl(heptyl)ammonium ion, a methyl(octyl)ammonium ion, a methyl(nonyl)ammonium ion, a methyl(decyl)ammonium ion, a methyl(undecyl)ammonium ion, a methyl(dodecyl)ammonium ion, a methyl(tridecyl)ammonium ion, a methyl(tetradecyl)ammonium ion, a methyl(pentadecyl)ammonium ion, a methyl(hexadecyl)ammonium ion, a methyl(heptadecyl)ammonium ion, a methyl(octadecyl)ammonium ion, a methyl(nonadecyl)ammonium ion, a methyl(icosyl)ammonium ion, a methyl(henicosyl)ammonium ion, a methyl(tricosyl)ammonium ion, an ethyl(propyl)ammonium ion, an ethyl(butyl)ammonium ion, an ethyl(pentyl)ammonium ion, an ethyl(hexyl)ammonium ion, an ethyl(heptyl)ammonium ion, an ethyl(octyl)ammonium ion, an ethyl(nonyl)ammonium ion, an ethyl(decyl)ammonium ion, an ethyl(undecyl)ammonium ion, an ethyl(dodecyl)ammonium ion, an ethyl(tridecyl)ammonium ion, an ethyl(tetradecyl)ammonium ion, an ethyl(pentadecyl)ammonium ion, an ethyl(hexadecyl)ammonium ion, an ethyl(heptadecyl)ammonium ion, an ethyl(octadecyl)ammonium ion, an ethyl(nonadecyl)ammonium ion, an ethyl(icosyl)ammonium ion, an ethyl(henicosyl)ammonium ion, an ethyl(tricosyl)ammonium ion, a dimethyl(ethyl)ammonium ion, a dimethyl(propyl)ammonium ion, a dimethyl(butyl)ammonium ion, a dimethyl(pentyl)ammonium ion, a dimethyl(hexyl)ammonium ion, a dimethyl(heptyl)ammonium ion, a dimethyl(octyl)ammonium ion, a dimethyl(nonyl)ammonium ion, a dimethyl(decyl)ammonium ion, a dimethyl(undecyl)ammonium ion, a dimethyl(dodecyl)ammonium ion, a dimethyl(tridecyl)ammonium ion, a dimethyl(tetradecyl)ammonium ion, a dimethyl(pentadecyl)ammonium ion, a dimethyl(hexadecyl)ammonium ion, a dimethyl(heptadecyl)ammonium ion, a dimethyl(octadecyl)ammonium ion, a dimethyl(nonadecyl)ammonium ion, a dimethyl(icosyl)ammonium ion, a dimethyl(henicosyl)ammonium ion, a dimethyl(tricosyl)ammonium ion, a monobenzylammonium ion, a (1-phenethyl)ammonium ion, a (2-phenethyl)ammonium ion, a dibenzylammonium ion, a bis(1-phenethyl)ammonium ion, a bis(2-phenethyl)ammonium ion, a monocyclopentylammonium ion, a dicyclopentylammonium ion, a tricyclopentylammonium ion, a monocyclohexylammonium ion, a dicyclohexyl ammonium ion, a monocycloheptylammonium ion, a dicycloheptylammonium ion, a dimethyl(cyclopentyl)ammonium ion, a dimethyl(cyclohexyl)ammonium ion, a dimethyl(cycloheptyl)ammonium ion, a (methylcyclopentyl)ammonium ion, a bis(methylcyclopentyl)ammonium ion, a (dimethylcyclopentyl)ammonium ion, a bis(dimethylcyclopentyl)ammonium ion, a (ethylcyclopenty)ammonium ion, a bis(ethylcyclopentyl)ammonium ion, a (methylethylcyclopentyl)ammonium ion, a bis(methylethylcyclopentyl)ammonium ion, a (diethylcyclopentyl)ammonium ion, a (methylcyclohexyl)ammonium ion, a bis(methylcyclohexyl)ammonium ion, a (dimethylcyclohexyl)ammonium ion, a bis(dimethylcyclohexyl)ammonium ion, an (ethylcyclohexyl)ammonium ion, a bis(ethylcyclohexyl)ammonium ion, a (methylethylcyclohexyl)ammonium ion, a (diethylcyclohexyl)ammonium ion, a (methylcycloheptyl)ammonium ion, a bis(methylcycloheptyl)ammonium ion, a (dimethylcycloheptyl)ammonium ion, an (ethylcycloheptyl)ammonium ion, a (methylethylcycloheptyl)ammonium ion, a (diethylcycloheptyl)ammonium ion, a monomethanolammonium ion, a dimethanolammonium ion, a monoethanolammonium ion, a diethanolammonium ion, a mono(n-propanol)ammonium ion, a di(n-propanol)ammonium ion, a monoisopropanolammonium ion, a diisopropanolammonium ion, a monobutanolammonium ion, a dibutanolammonium ion, a tributanolammonium ion, a monopentanolammonium ion, a dipentanolammonium ion, a tripentanolammonium ion, a monohexanolammonium ion, a dihexanolammonium ion, a monoheptanolammonium ion, a diheptanolammonium ion, a monooctanolammonium ion, a monononanolanamonium ion, a monodecanolammonium ion, a monoundecanolammonium ion, a monododecanolammonium ion, a monotridecanolammonium ion, a monotetradecanolammonium ion, a monopentadecanolammonium ion, a monohexadecanolammonium ion, a monomethylmonoethanolammonium ion, a monoethylmonoethanolammonium ion, a monoethylmonopropanolammonium ion, a monoethylmonobutanolammonium ion, a monoetylpentanolammonium ion, a monopropylmonoethanolammonium ion, a monopropylmonopropanolammonium ion, a monopropylmonobutanolammonium ion, a monopropylmonopentanolammonium ion, a monobutylmonoethanolammonium ion, a monobutylmonopropanolammonium ion, a monobutylmonobutanolammonium ion, a monobutylmonopentanolammonium ion, a dimethylmonoethanolammonium ion, a diethylmonoethanolammonium ion, a diethylmonopropanolammonium ion, a diethylmonobutanolammonium ion, a diethylmonopentanolammonium ion, a dipropylmonoethanolammonium ion, a dipropylmonopropanolammonium ion, a dipropylmonobutanolammonium ion, a dipropylmonopentanolammonium ion, a dibutylmonoethanolammonium ion, a dibutylmonopropanolammonium ion, a dibutylmonobutanolammonium ion, a dibutylmonopentanolammonium ion, a monomethyldiethanolammonium ion, a monomethyldipropanolammonium ion, a monomethyldibutanolammonium ion, a monomethyldipentanolammonium ion, a monoethyldiethanolammonium ion, a monoethyldipropanolammonium ion, a monoethyldibutanolammonium ion, a monoethyldipentanolammonium ion, a monopropyldiethanolammonium ion, a monopropyldipropanolammonium ion, a monopropyldibutanolammonium ion, a monopropyldipentanolammonium ion, a monobutyldiethanolammonium ion, a monobutyidipropanolammonium ion, a monobutyldibutanolammonium ion, a monobutyldipentanolammonium ion, a monocyclohexylmonoethanolammonium ion, a monocyclohexyldiethanolammonium ion, a monocyclohexylmonopropanolammonium ion, a monocyclohexyldipropanolammonium ion, a mono(?-aminoethyl)monoethanolammonium ion, a monotert-butylmonoethanolammonium ion, and a mono(?-aminoethyl)isopropanolammonium ion,

in the Chemical Formula (2) above, R2represents 1,2-Bis(2-ethylhexyloxycarbonyl)ethyl group, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms where the aryl group is not substituted with an alkyl group, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms with the proviso that the aryl group is not a naphthyl group or not substituted with a substituted or unsubstituted phenyl group,
A is a linear or branched alkylene group having from 2 to 4 carbon atoms,
n represents an integer of 1 to 50,
Q2 represents at least one kind selected from the group consisting of a monomethanolammonium ion, a dimethanolammonium ion, a monoethanolammonium ion, a diethanolammonium ion, a mono(n-propanol)ammonium ion, a di(n-propanol)ammonium ion, a monoisopropanolammonium ion, a diisopropanolammonium ion, a monobutanolammnonium ion, a dibutanolammonium ion, a tributanolammonium ion, a monopentanolammonium ion, a dipentanolammonium ion, a tripentanolammonium ion, a monohexanolammonium ion, a dihexanolammonium ion, a monononanolammonium ion, a diheptanolammonium ion, a monooctanolammonium ion, a monononanolammonium ion, a monodecanolammonium ion, a monoundecanolammonium ion, a monoclodecanolammonium ion, a monotridecanolammonium ion, a monotetradecanolammonium ion, a monopentadecanolammonium ion, a monohexadecanolammonium ion, a monomethylmonothanolammonium ion, a monoethylmonoethanolammonium ion, a monoethylmonopropanolamnonium ion, a monoethylmonobutanolammonium ion, a monoethylpentanolammonium ion, a monopropylmonoethanolammonium ion, a monopropylmonopropanolammonium ion, a monopropylmonobutanolammonium ion, a monopropylmonopentanolammonium ion, a monobutymonoethanolammonium ion, a monobutylmonopentanolammonium ion, a monobutylmonobutanolammonium ion, a monobutylmonopentanolammonium ion, a dimethylmonoethanolammonium ion, a diethylmonoethanolammonium ion, a diethylmonopropanolammonium ion, a diethylmonobutanolammonium ion, a diethylmonopentanolammonium ion, a dipropylmonoethanolammonium ion, a dipropylmonopropanolammonium ion, a dipropylmonobutanolammonium ion, a dipropylmonopentanolammonium ion, a dibutylmonoethanolammonium ion, a dibutylmonopentanolammonium ion, a dibutylmonobutanolammonium ion, a dibutylmonopentanolammonium ion, a monomethyldiethanolammonium ion, a monomethyldipropanolammonium ion, a monomethyldibutanolammonium ion, a monomethyldipetanolammonium ion, a monoethyldiethanolammonium ion, a monoethyldipropanolammonium ion, a monoethyldibutanolammonium ion, a monoethyldipentanolammonium ion, a monopropyldiethanolammonium ion, a monopropyldipropanolammonium ion, a monopropyldibutanolammonium ion, a monopropyldipentanolammonium ion, a monobutyldiethanolammonium ion, a monobutyldipropanolammonium ion, a monobutyldibutanolaumonium ion, a monobutyldipentanolammonium ion, a monocyclohexylmonoethanolammonium ion, a monocyclohexyldiethanolammonium ion, a monocyclohexylmonopropanolammonium ion, a monocyclohexyldipropanolammonium ion, a mono(?-aminoethyl)monoethanolammenium ion, a monotert-butylmonoethanolammonium ion, a monotert-butyldiethanolammonium ion, a mono(?-aminoethyl)isopronanolammonium ion, and a diethylmonoisopropanolammonium ion, wherein the thermoplastic resin composition is in the form of an emulsion when the (b) ionically bonded salt is represented by the Chemical Formula (1) above.

US Pat. No. 10,113,047

EXFOLIATED GRAPHITE-RESIN COMPOSITE MATERIAL AND METHOD FOR PRODUCING THE SAME

SEKISUI CHEMICAL CO., LTD...

1. An exfoliated graphite-resin composite material comprisingan exfoliated graphite and
a resin
said exfoliated graphite and said resin forming the exfoliated graphite-resin composite, and
when an amount of methylene blue adsorbed per g of the exfoliated graphite-resin composite material (?mol/g) is y, the amount of methylene blue adsorbed as measured based on a difference between an absorbance of a methanol solution of methylene blue at a concentration of 10 mg/L and an absorbance of a supernatant liquid obtained by introducing the exfoliated graphite-resin composite material into the methanol solution of methylene blue and performing centrifugation, and a BET specific surface area (m2/g) of the exfoliated graphite-resin composite material is x,
a ratio y/x being 0.15 or more, and the BET specific surface area being 25 m2/g or more, and
said exfoliated graphite-resin composite has a graphite structure in the central portion and has an exfoliated structure in the edge portion.

US Pat. No. 10,113,045

MOLDED FOAM ARTICLE, FOAMED SOLE, AND SHOE

ASICS CORPORATION, (JP)

1. A molded foam article comprising:a foam obtained by foaming a formation material, wherein the formation material of the foam comprises (i) at least one resin component selected from a thermoplastic elastomer, a thermoplastic resin, and a rubber, and (ii) at least one softener selected from a vegetable oil and a mineral oil,
wherein an Asker C hardness of the foam is 10 degrees or more,
wherein the at least one resin component and the at least one softener are selected such that a ratio E40/E0 of the foam is (i) equal to or more than 0.5 and (ii) equal to or less than 3.5, the ratio E40/E0 being a ratio of an elastic coefficient E40 at a compressive strain of 40% in relation to an elastic coefficient E0 at a compressive strain of 0% of the foam, and
wherein a difference between (i) H1 as an Asker C hardness when a load of 0.1 MPa is applied and (ii) H0 as an Asker C hardness in a no load state, is within a range of ±20 degrees.

US Pat. No. 10,113,044

METHODS OF PROCESSING LATEX, METHODS OF MAKING CARPET, AND CARPETS

SST Foam, LLC, Alpharett...

1. A method of processing a latex stream, the method comprising:forwarding the latex stream to a reservoir of a foam head;
disposing an isocyanate into the reservoir of the foam head to form a foamed latex stream comprising the isocyanate; and
forwarding the foamed latex stream comprising the isocyanate from the reservoir of the foam head to a coating line;
wherein the concentration of the isocyanate in the foamed latex stream is about 0.5 to about 2.25%, by weight of the latex stream.

US Pat. No. 10,113,037

SILICONE SURFACTANT, W/O EMULSION COMPOSITION, POWDER COMPOSITION, AND COSMETIC/MEDICAL APPLICATION THEREOF

DOW CORNING TORAY CO., LT...

1. A silicone surfactant comprising a co-modified organopolysiloxane represented by the following general formula (1):
wherein
R1 is a monovalent hydrocarbon group having from 1 to 30 carbons, or is a hydrogen atom;
R2 is a straight or branched monovalent hydrocarbon group having from 6 to 30 carbons;
Q is a hydrophilic group consisting of a polyoxyalkylene group represented by structural formula (2):
—(C2H4O)r—(C3H6O)s—R3
wherein
R3 is a hydrogen atom or an alkyl group having from 1 to 4 carbons,
r is a number in a range of 0 to 100,
s is a number in a range of 0 to 50, and
r+s is a number in a range of 3 to 100;
R is a group selected from R1, R2, and Q;
provided that, when n3=0, at least one R is Q;
(n1+n2+n3) is a number in a range of 40 to 75;
n1 is a number in a range of 1 to 65;
n2 is a number in a range of 1 to 20; and
n3 is a number in a range of 0 to 5.

US Pat. No. 10,113,032

AMINE FUNCTIONAL POLYAMIDES

Genzyme Corporation, Cam...

1. A compound comprising the structure of Formula (II):
wherein:
i) m is 1, 2, or 3;
ii) n is 0, 1, 2, or 3;
iii) o is 1, 2, or 3;
iv) q is an integer from 1 to 400;
v) Qx is NH, (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl;
vi) Qv is NH—Rw, NH—CH2—Rw, (C1-C10)alkyl, or (C6-C14)aryl, wherein Rw is absent or a (C1-C10)alkyl, (C2-C9)heteroalkyl, (C6-C14)aryl, or (C2-C9)heteroaryl;
vii) Rx and Ry are each independently a pharmaceutically acceptable end group;
viii) X? is each independently a halo or any pharmaceutically acceptable anion;
ix) Y1 and Y2 are each independently H or (C1-C10)alkyl optionally substituted by one or more substituents selected from the group consisting of (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, —S—O—(C1-C10)alkyl, —O(O)C—(C1-C10)alkyl, —(C1-C10)alkyl-COOH, (C3-C10)cycloalkyl-COOH, —(O)CH3, —OH, amide, a dihydroxy group, represented by Formula (D),

wherein d is an integer from 0 to 25, or
a polyethylene glycol group, represented by Formula (E)

wherein e is an integer from 1 to 25, and provided that Y1 and Y2 are not both H.

US Pat. No. 10,113,031

AROMATIC DISPERSANT COMPOSITION

1. A polymer represented by Formula (1):
wherein dispersant of Formula (1) has a terminal and/or pendant imide group, wherein the side chain imide group is derived from an imide compound represented by Formula (1a):

wherein
R1 is a substituent on Q ring in any position available for bonding to a substituent group and R1 is independently represented by one or more of —H, or an electron withdrawing group selected from the group of: —NO2, —SO2NR?2, —C(O)R?, —SO3M, halo, —NH2, and —OR? or an electron releasing alkyl group, a is the total number of sites on the Q ring available for bonding a H, electron withdrawing groups, and electron releasing groups, when R1 is said electron withdrawing group or said alkyl group, then the total number of electron withdrawing and alkyl groups is 1 or 2; M is H, a metal cation, NR?4+, or mixtures thereof; R? is —H, an optionally-substituted alkyl containing 1 to 20 carbon atoms, and the substituent is hydroxyl or halo or mixtures thereof;
Q is a fused or non-fused aromatic ring containing 4n+2 ?-electrons, wherein n=1 or more, and Q is bonded to the imide group in such a way to form a 5 or 6 membered imide ring;
R2 is a C1 to C20 hydrocarbylene group or mixtures thereof; R2 optionally includes oxygen and/or nitrogen atoms wherein there is at least 2 carbon atoms per every oxygen or nitrogen of R2 these would include ether, ester, and amide type linkages in R2;
Pol is a residue of a diepoxide or polyepoxide further comprising at least one pendant side chain of one or more of:
a polyether,
a polyester,
a mixed polyether/polyester pendant side chains thereof,
a mixed polyester/polyether pendant side chains thereof,
or mixtures thereof,
the bond(s) between Pol and each W? allows for one or more terminal and/or pendant side chain imide groups (as defined by w) to be attached to Pol at one or more locations on Pol and for each imide group to be attached to Pol by one or more bond (as defined by b);
W is any group capable of reaction with an epoxide group;
W? represents amino, carboxylic acid and hydroxyl with the H missing and is a residue of the reaction of an amino, hydroxyl or carboxyl group, with a diepoxide or polyepoxide in a reaction forming a chemical bond between an amino, hydroxy, or carboxyl group with an epoxide; when b is 2 then one of the W? is derived from a secondary amine reacted with said epoxide and optionally is in the R2 linking group between the imide and the other W? group, when b is 2 each W? group is the same or different;
b is 1 or 2 and when b is 1, the imide group can either be terminal and attached to the Pol by one chemical bond when W is hydroxyl or carboxylic acid, or a pendant side chain when W is NH2 and when b is 2 the imide group is a side chain attached to Pol by two chemical bonds;
d is 1, 2, or 3; this means that there is the possibility of 1 to 3 imide groups attached to R2 at different carbon atoms of R2; and
w is 1 or more.

US Pat. No. 10,113,030

RESIST MATERIAL AND PATTERN FORMING METHOD USING SAME

Toshiba Memory Corporatio...

1. A pattern forming method comprising:providing, on a substrate, a resist material which comprises a diluent monomer having a hydroxyl group and at least one functional group selected from a vinyl ether group, an epoxy group and an oxetanyl group, a dendrimer with a globular structure having at least two reactive groups for photo-cationic polymerization, and a photo-acid generator as a polymerization initiator;
imprinting a template having concave-convex shape patterns against the resist material;
curing the resist material; and
releasing the template from the cured resist material.

US Pat. No. 10,113,028

EPOXY RESIN, CURABLE RESIN COMPOSITION, CURED PRODUCT, SEMICONDUCTOR ENCAPSULATING MATERIAL, SEMICONDUCTOR DEVICE, PREPREG, CIRCUIT BOARD, BUILDUP FILM, BUILDUP SUBSTRATE, FIBER-REINFORCED COMPOSITE MATERIAL AND FIBER-REINFORCED MOLDED ARTICLE

DIC Corporation, Tokyo (...

1. An epoxy resin, comprising as essential components, a cresol-naphthol co-condensed novolac epoxy resin (A), a naphthol glycidyl ether compound (B), and one or more xanthene compounds (C) selected from the group of compounds represented by the following structural formulae (1) to (3), wherein the content of the xanthene compound(s) (C) is from 0.1% to 5.5% in terms of area ratio in a GPC measurement:wherein in the structural formulae (1) to (3), R? each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, m each independently represents an integer of 1 to 6,wherein the content of the glycidyl ether compound (B) is from 0.1% to 4.0% in terms of area ratio in a GPC measurement.

US Pat. No. 10,113,023

ANTISTATIC POLYMERS AND METHODS OF MAKING THE SAME

3M Innovative Properties ...

1. An antistatic polymer consisting of:divalent segments p) represented by the formula

wherein
R1 independently represents an alkyl group having from 1 to 18 carbon atoms,
R2 and R3 independently represent alkyl groups having from 1 to 4 carbon atoms,
R4 independently represents an alkylene group having from 2 to 8 carbon atoms, and
R5 independently represents H or methyl; and
divalent segments q) represented by the formula)

US Pat. No. 10,113,022

PHOTORESIST POLYMERS AND METHODS OF FORMING PATTERNS

Samsung Electronics Co., ...

6. A photoresist polymer synthesized from a repeating unit, the repeating unit comprising:a first leaving group including an ester group; and
a second leaving group capable of being removed with the first leaving group,
wherein the first leaving group and the second leaving group are positioned in one of a staggered conformation and an anti-periplanar configuration,
wherein the second leaving group includes a tosylate group.

US Pat. No. 10,113,021

PROPYLENE RANDOM COPOLYMER

Borealis AG, Vienna (AT)...

1. A process for preparing a propylene random copolymers, comprising:copolymerising propylene with a comonomer selected from ethylene, C4-C20-alpha olefin, and any combination thereof using a catalyst system comprising a co-catalyst and optionally an external electron donor and an olefin polymerisation catalyst component in the form of solid particles being produced by
a) preparing a solution of at least one alkoxy compound (Ax) being the reaction product of at least one compound of a Group 2 metal with at least a monohydric alcohol (A) in an organic liquid reaction medium,
b) adding said solution to at least one compound of a transition metal and
c) preparing the solid catalyst component particles,
wherein an internal electron donor selected from benzoates, alkylene glycol dibenzoates, maleates, 1-cyclohexene-1,2-dicarboxylic dialkylester, and 1,3-ethers, or a mixture of any selected donors, or a corresponding precursor is added at any step prior to step c),
wherein the propylene random copolymer has
i) the comonomer selected from ethylene, C4-C20-alpha olefin, and any combination thereof
ii) a comonomer content in the range of 1.5 to at most 5.0 wt %
iii) a randomness in the range of 60% to at most 80%
iv) a xylene soluble (XS) content of 2 to <12 wt %, and
the propylene random copolymers is free from catalyst originating phthalates,
wherein in addition to the at least one alkoxy compound (Ax) at least one alkoxy compound (Bx) is present, being the reaction product of at least one compound of Group 2 metal and an alcohol (B) comprising in addition to the hydroxyl moiety at least one further oxygen bearing group being different to a hydroxyl moiety.

US Pat. No. 10,113,012

CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS

Basell Poliolefine Italia...

1. A solid catalyst component for the (co)polymerization of olefins CH2?CHRx, in which Rx is hydrogen or a hydrocarbyl radical with 1-12 carbon atoms, comprising Ti, Mg, and Cl, an electron donor compound selected from the group consisting of carbamates, ketones, esters of malonic acids, esters of glutaric acids, esters of maleic acids, esters of succinic acids, alkyl and aryl esters of optionally substituted aromatic polycarboxylic acids, diol derivatives chosen among monoesters monocarbamates and monoesters monocarbonates, and 1,3-diethers of general formulawherein R, RI, RII, RIII, RIV and RV, equal or different to each other, are hydrogen or hydrocarbon radicals having from 1 to 18 carbon atoms, and RvI and RVII, equal or different from each other, have the same meaning of R-RV except that they cannot be hydrogen; and one or more of the R-RVII groups can be linked to form a cycle, or mixtures thereof, and from 0.1 to 50% by weight of bismuth (Bi) with respect to the total weight of the solid catalyst component.

US Pat. No. 10,113,008

STARCH SETTLING RECOVERY SYSTEM

1. A process consisting essentially of:a. obtaining a waste water stream having starch content between 0.1 and 5% by weight starch and feeding the waste water stream to a classifier to concentrate the slurry by a factor of at least 5 and produce a concentrated slurry, wherein the classifier has at least one overflow exit and at least one underflow exit;
b. drawing off the overflow and underflow from the classifier;
c. feeding the concentrated slurry from the underflow exit of the classifier into a settling tank having at least one settling tank underflow exit and at least one settling tank overflow exit, to produce a settling tank underflow layer of starch with a concentration of between 40 and 60% starch, the settling tank underflow layer being proximate to the settling tank's underflow exit and an aqueous settling tank overflow layer having a starch concentration of less than 5% by weight starch proximate to the settling tank overflow exit,
d. allowing the settling tank underflow layer to exit through the settling tank underflow exit as a starch cake having moisture content between 40 and 60%; and
e. collecting the starch cake for shipping.

US Pat. No. 10,112,976

PROCESS FOR THE PRODUCTION OF D-ARGINYL-2,6-DIMETHYL-L-TYROSYL-L-LYSYL-L-PHENYLALANINAMIDE

1. A liquid-phase process for the production of H-D-Arg-(2,6-Dimethyl)Tyr-Lys-Phe-NH2 of formula (I), in the form of the trifluoroacetic acid salt,
which comprises the following steps:
coupling compound (II) H-Phe-NH2:

with compound (III) Z-Lys(Boc)-OH:

to obtain a compound of formula (IV), Z-Lys-Lys(Boc)-Phe-NH2:

reacting compound (IV) with hydrogen and methanesulfonic acid (V)
MeSO3H  (V)
in the presence of a catalyst to obtain the free amine salt (VI) MeSO3H.H-Lys(Boc)-Phe-NH2:

reacting salt (VI) with the protected amino acid Z-Dmt(Boc)-OH (VII)

to obtain the protected tripeptide Z-Dmt(Boc)-Lys(Boc)-Phe-NH2 (VIII):

treating compound (VIII) with hydrogen and methanesulfonic acid (V) to obtain the corresponding salt MeSO3.H-Dmt(Boc)-Lys(Boc)-Phe-NH2 (IX):

coupling the acid salt (IX) with Z-D-Arg-ONa (X)

to form the protected tetrapeptide Boc-D-Arg-Dmt(Boc)-Lys(Boc)-Phe-NH2 (XI):

deprotecting compound (XI) to obtain the tetrapeptide H-D-Arg-Dmt-Lys-Phe-NH2 (I) and further salifying it with trifluoroacetic acid in solvents.

US Pat. No. 10,112,974

METHOD FOR THE PRODUCTION OF 18F-LABELED ACTIVE ESTERS AND THEIR APPLICATION EXEMPLIFIED BY THE PREPARATION OF A PSMA-SPECIFIC PET-TRACER

Max-Planck-Gesellschaft z...

1. A compound of formula (II)wherein, E represents a covalent bond orwhereinn is an integer selected from 0 to 10;
n1 is an integer selected from 0 to 10;
n2 is an integer selected from 0 to 10;
m is an integer selected from 1 to 18;
p is an integer selected from 0 to 10;
q is an integer selected from 1 to 18;
X, Y, W, and Z represent independently of each other —CH2—, —CH—, —NH— or —N—;
represents a single or double bond;
and diastereomers, entantiomers, hydrates, and salts thereof.

US Pat. No. 10,112,969

COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS

INDUSTRIAL TECHNOLOGY RES...

1. A compound having Formula I:
or a pharmaceutically acceptable salt or hydrate thereof, wherein
n is 1, 2, 3, 4, 5, 6, 7, 8, or 9;
i) R1 and each R2 are O?; or
ii) R1 is

 and each R2 is O?; or
iii) R1 is O?, one R2 is

 and any remaining R2 is independently O?, S?, BH3?, or CH3;
R3 is a nucleotide moiety comprising a fluorescent dye F and at least one non-complementary nucleotide residue;
R4 is H, OH, halogen, alkyl (both substituted and unsubstituted), or alkoxy (both substituted and unsubstituted);
Y1, and Y3 are each independently chosen from O?, S?, BH3?, and CH3;
L1 is chosen from alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, ester, amino, and sulfonyl;
Q is a fluorescence quenching moiety; and
B1 is chosen from adenine, cytosine, guanine, thymine, uracil, hypoxanthine, and 5-methylcytosine.

US Pat. No. 10,112,967

PROCESS FOR THE PREPARATION OF SOFOSBUVIR

HC-PHARMA AG, Zug (CH)

1. A process for the synthesis of Sofosbuvir of formula (I)
comprising
selectively mono-deacetylating a compound of formula (V)

enzymatically using a resin supported lipase B derived from Candida Antarctica in a polar protic solvent at a temperature from 40° C. to 70° C. to obtain a compound of formula (IV)

converting the compound of formula (IV) to a compound of formula (II)

by reacting the compound of formula (IV) with a compound of formula (III)

wherein F5 indicates that the aromatic ring is pentafluoro substituted, and
converting the compound of formula (II) to Sofosbuvir of formula (I) by deacetylation reaction.

US Pat. No. 10,112,966

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Alios BioPharma, Inc., S...

1. A compound selected from the group consisting of:or a pharmaceutically acceptable salt of the foregoing.

US Pat. No. 10,112,965

BICYCLIC BRIDGED METALLOCENE COMPOUNDS AND POLYMERS PRODUCED THEREFROM

Chevron Phillips Chemical...

1. A metallocene compound having the formula:wherein:M is Ti, Zr, or Hf;
each X independently is a monoanionic ligand;
E is a norbornane group, a norbornene group, a norbornadiene group, an indane group, an indene group, or a dicyclopentadiene group; and
Cp1 and Cp2 independently are a substituted or unsubstituted cyclopentadienyl, indenyl, or fluorenyl group.

US Pat. No. 10,112,962

BORON-BASED PRODRUG STRATEGY FOR INCREASED BIOAVAILABILITY AND LOWER-DOSAGE REQUIREMENTS FOR DRUG MOLECULES CONTAINING AT LEAST ONE PHENOL (OR AROMATIC HYDROXYL) GROUP

XAVIER UNIVERSITY, New O...

1. A compound of Formula 29:
wherein R is selected from the group consisting of:

 KF3B; (HO)2B; and NaF3B; and
wherein the boron atom is the point of attachment in each R variable substituent, and any salts thereof.

US Pat. No. 10,112,961

HYDROBORATION AND BORYLATION WITH COBALT CATALYSTS

The Trustees of Princeton...

1. A method of providing a borylated product comprising:providing a reaction mixture comprising an aliphatic compound or an aromatic compound, a borylation reagent and a cobalt complex having Formula (IV):
wherein X1 and X2 are independently selected from Group VIIA of the Periodic Table and R1-R11 are independently selected from the group consisting of hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyl-aryl and alkyl-heteroaryl, wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyl-aryl and alkyl-heteroaryl are optionally substituted with one or more substituents selected from the group consisting of (C1-C10)-alkyl, (C1-C10)-alkenyl, alkoxy, halo, hydroxy, C(O)OR12, NR13R14, wherein R12-R14 are independently selected from the group consisting of hydrogen, (C1-C10)-alkyl and (C1-C10)-alkenyl;adding an activator to the reaction mixture to activate the cobalt complex; and
reacting the aliphatic compound or aromatic compound with the borylation reagent in the presence of the activated cobalt complex or a derivative of the activated cobalt complex.

US Pat. No. 10,112,960

METHODS FOR PRODUCING BORYLATED ARENES

Dow AgroSciences LLC, In...

1. A method of forming a borylated arene comprising:providing a substrate comprising a substituted arene ring comprising from 1 to 4 substituents, wherein the arene ring is unsubstituted at a first position that is electronically favored for CH-activation and unsubstituted at a second position that is sterically favored for CH-activation; and
contacting the substrate with an iridium precursor complex, an electron deficient bidentate ligand comprising at least one nitrogen heteroatom, and a borylation reagent under conditions effective to form a first borylated arene and optionally a second borylated arene;
wherein the electron deficient bidentate ligand comprises a compound defined by Formula IVa

wherein n is 0, 1, 2, or 3 and R10 is, independently for each occurrence, hydrogen, a halogen, a nitrile group, a nitro group, a C1-C6 alkyl group, or a C1-C6 perfluoroalkyl group, with the proviso that at least one of R10 is chosen from a halogen, a nitrile group, a nitro group, and a C1-C6 perfluoroalkyl group;
wherein the first borylated arene comprises a substituted arene ring comprising from 1 to 4 substituents and a boronic acid or a boronic acid derivative in the first position,
wherein the second borylated arene, when formed, comprises a substituted arene ring comprising from 1 to 4 substituents and a boronic acid or a boronic acid derivative in the second position, and
wherein the molar ratio of the first borylated arene to the second borylated arene is at least 1:1, as determined by GC-FID.

US Pat. No. 10,112,957

THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES

Dana-Farber Cancer Instit...

1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, wherein:each instance of RA1 is independently halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORa, —N(Ra)2, —SRa, —CN, —SCN, —C(?NRa)Ra, —C(?NRa)ORa, —C(?NRa)N(Ra)2, —C(?O)Ra, —C(?O)ORa, —C(?O)N(Ra)2, —NO2, —NRaC(?O)Ra, —NRaC(?O)ORa, —NRaC(?O)N(Ra)2, —OC(?O)Ra, —OC(?O)ORa, or —OC(?O)N(Ra)2;
each instance of Ra is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of Ra are joined to form a substituted or unsubstituted, heterocyclic ring, or substituted or unsubstituted, heteroaryl ring;
k is 0, 1, 2, 3, 4, or 5;
LA is —C(?O)—NRA2— or —NRA2—C(?O)—, wherein RA2 is hydrogen, substituted or unsubstituted C1-6 alkyl, or a nitrogen protecting group;
RA3 is hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORa, —N(Ra)2, —SRa, —CN, —SCN, —C(?NRa)Ra, —C(?NRa)ORa, —C(?NRa)N(Ra)2, —C(?O)Ra, —C(?O)ORa, —C(?O)N(Ra)2, —NO2, —NRaC(?O)Ra, —NRaC(?O)ORa, —NRaC(?O)N(Ra)2, —OC(?O)Ra, —OC(?O)ORa, or —OC(?O)N(Ra)2;
RA4 is hydrogen, substituted or unsubstituted C1-6 alkyl, or a nitrogen protecting group;
each instance of RA5 is independently halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORa, —N(Ra)2, —SRa, —CN, —SCN, —C(?NRa)Ra, —C(?NRa)ORa, —C(?NRa)N(Ra)2, —C(?O)Ra, —C(?O)ORa, —C(?O)N(Ra)2, —NO2, —NRaC(?O)Ra, —NRaC(?O)ORa, —NRaC(?O)N(Ra)2, —OC(?O)Ra, —OC(?O)ORa, or —OC(?O)N(Ra)2;
m is 0, 1, or 2;
RA6 is hydrogen, substituted or unsubstituted C1-6 alkyl, or a nitrogen protecting group; and
RA7 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroaryl, —C(?O)Ra, —C(?O)ORa, —C(?O)N(Ra)2, or a nitrogen protecting group;
wherein:
each substituent at a carbon atom is independently halogen, —CN, —NO2, —N3, —SO2H, —SO3H, —OH, —ORaa, —ON(Rbb)2, —N(Rbb)2, —N(Rbb)3+X?, —N(ORcc)Rbb, —SH, —SRaa, —SSRcc, —C(?O)Raa, —CO2H, —CHO, —C(ORcc)2, —CO2Raa, —OC(?O)Raa, —OCO2Raa, —C(?O)N(Rbb)2, —OC(?O)N(Rbb)2, —NRbbC(?O)Raa, —NRbbCO2Raa, —NRbbC(?O)N(Rbb)2, —C(?NRbb)Raa, —C(?NRbb)ORaa, —OC(?NRbb)Raa, —OC(?NRbb)ORaa, —C(?NRbb)N(Rbb)2, —OC(?NRbb)N(Rbb)2, —NRbbC(?NRbb)N(Rbb)2, —C(?O)NRbbSO2Raa, —NRbbSO2Raa, —SO2N(Rbb)2, —SO2Raa, —SO2ORaa, —OSO2Raa, —S(?O)Raa, —OS(?O)Raa, —Si(Raa)3, —OSi(Raa)3, —C(?S)N(Rbb)2, —C(?O)SRaa, —C(?S)SRaa, —SC(?S)SRaa, —SC(?O)SRaa, —OC(?O)SRaa, —SC(?O)ORaa, —SC(?O)Raa, —P(?O)(Raa)2, —P(?O)(ORcc)2, —OP(?O)(Raa)2, —OP(?O)(ORcc)2, —P(?O)(N(Rbb)2)2, —OP(?O)(N(Rbb)2)2, —NRbbP(?O)(Raa)2, —NRbbP(?O)(ORcc)2, —NRbbP(?O)(N(Rbb)2)2, —P(Rcc)2, —P(ORcc)2, —P(Rcc)3+X?, —P(ORcc)3+X?, —P(Rcc)4, —P(ORcc)4, —OP(Rcc)2, —OP(Rcc)3+X?, —OP(ORcc)2, —OP(ORcc)3+X?, —OP(Rcc)4, —OP(ORcc)4, —B(Raa)2, —BRaa(ORcc), C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, heterocyclyl, C6-14 aryl, or heteroaryl, wherein each one of the alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
or two geminal hydrogens on a carbon atom are replaced with the group ?O, ?S, ?NN(Rbb)2, ?NNRbbC(?O)Raa, ?NNRbbC(?O)ORaa, ?NNRbbS(?O)2Raa, ?NRbb, or ?NORcc;
each substituent on a nitrogen atom is independently hydrogen, —OH, —ORaa, —N(Rcc)2, —CN, —C(?O)Raa, —C(?O)N(Rcc)2, —CO2Raa, —SO2Raa, —C(?NRbb)Raa, —C(?NRcc)ORaa, —C(?NRcc)N(Rcc)2, —SO2N(Rcc)2, —SO2Rcc, —SO2Rcc, —SO2ORcc, —SORaa, —C(?S)N(Rcc)2, —C(?O)SRcc, —C(?S)SRcc, —P(?O)(ORcc)2, —P(?O)(Raa)2, —P(?O)(N(Rcc)2)2), C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, heterocyclyl, C6-14 aryl, or heteroaryl, wherein each one of the alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of the acyl is independently —C(?O)Raa, —CHO, —CO2Raa, —C(?O)N(Rbb)2, —C(?NRbb)Raa, —C(?NRbb)ORaa, —C(?NRbb)N(Rbb)2, —C(?O)NRbbSO2Raa, —C(?S)N(Rbb)2, —C(?O)SRaa, or —C(?S)SRaa;
each instance of Raa is independently C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, heterocyclyl, C6-14 aryl, or heteroaryl, or two Raa groups are joined to form heterocyclyl or heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Rbb is independently hydrogen, —OH, —ORaa, —N(Rcc)2, —CN, —C(?O)Raa, —C(?O)N(Rcc)2, —CO2Raa, —SO2Raa, —C(?NRcc)ORaa, —C(?NRcc)N(Rcc)2, —SO2N(Rcc)2, —SO2Rcc, —SO2Rcc, —SORaa, —C(?S)N(Rcc)2, —C(?O)SRcc, —C(?S)SRcc, —P(?O)(Raa)2, —P(?O)(ORcc)2, —P(?O)(N(Rcc)2)2), C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, heterocyclyl, C6-14 aryl, or heteroaryl, or two Rbb groups are joined to form heterocyclyl or heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Rcc is independently hydrogen, C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, heterocyclyl, C6-14 aryl, or heteroaryl, or two Rcc groups are joined to form heterocyclyl or heteroaryl, wherein each one of the alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Rdd is independently halogen, —CN, —NO2, —N3, —SO2H, —SO3H, —OH, —ORee, —ON(Rff)2, —N(Rff)2, —N(Rff)3+X?, —N(ORee)Rff, —SH, —SRee, —SSRee, —C(?O)Ree, —CO2H, —CO2Ree, —OC(?O)Ree, —OCO2Ree, —C(?O)N(Rff)2, —OC(?O)N(Rff)2, —NRffC(?O)Ree, —NRffCO2Ree, —NRffC(?O)N(Rff)2, —C(?NRff)ORee, —C(?NRff)Ree, —OC(?NRff)ORee, —C(?NRff)N(Rff)2, —OC(?NRff)N(Rff)2, —NRffC(?NRff)N(Rff)2, —NRffSO2Ree, —SO2N(Rff)2, —SO2Ree, —SO2ORee, —OSO2Ree, —S(?O)Ree, —Si(Ree)3, —OSi(Ree)3, —C(?S)N(Rff)2, —C(?O)SRee, —C(?S)SRee, —SC(?S)SRee, —P(?O)(ORee)2, —P(?O)(Ree)2, —OP(?O)(Ree)2, —OP(?O)(ORee)2, C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, heterocyclyl, C6-10 aryl, or heteroaryl, wherein each one of the alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rgg groups, or two geminal Rdd substituents are joined to form ?O or ?S;
each instance of Ree is independently C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, C6-10 aryl, heterocyclyl, or heteroaryl, wherein each one of the alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rgg groups;
each instance of Rff is independently hydrogen, C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, heterocyclyl, C6-10 aryl, or heteroaryl, or two Rff groups are joined to form heterocyclyl or heteroaryl, wherein each one of the alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rgg groups;
each instance of Rgg is independently halogen, —CN, —NO2, —N3, —SO2H, —SO3H, —OH, —OC1-6 alkyl, —ON(C1-6 alkyl)2, —N(C1-6 alkyl)2, —N(C1-6 alkyl)3+X?, —NH(C1-6 alkyl)2+X?, —NH2(C1-6 alkyl)+X?, —NH3+X?, —N(OC1-6 alkyl)(C1-6 alkyl), —N(OH)(C1-6 alkyl), —NH(OH), —SH, —SC1-6 alkyl, —SS(C1-6 alkyl), —C(?O)(C1-6 alkyl), —CO2H, —CO2(C1-6 alkyl), —OC(?O)(C1-6 alkyl), —OCO2(C1-6 alkyl), —C(?O)NH2, —C(?O)N(C1-6 alkyl)2, —OC(?O)NH(C1-6 alkyl), —NHC(?O)(C1-6 alkyl), —N(C1-6 alkyl)C(?O)(C1-6 alkyl), —NHCO2(C1-6 alkyl), —NHC(?O)N(C1-6 alkyl)2, —NHC(?O)NH(C1-6 alkyl), —NHC(?O)NH2, —C(?NH)O(C1-6 alkyl), —OC(?NH)(C1-6 alkyl), —OC(?NH)OC1-6 alkyl, —C(?NH)N(C1-6 alkyl)2, —C(?NH)NH(C1-6 alkyl), —C(?NH)NH2, —OC(?NH)N(C1-6 alkyl)2, —OC(NH)NH(C1-6 alkyl), —OC(NH)NH2, -NHC(NH)N(C1-6 alkyl)2, —NHC(?NH)NH2, —NHSO2(C1-6 alkyl), —SO2N(C1-6 alkyl)2, —SO2NH(C1-6 alkyl), —SO2NH2, —SO2C1-6 alkyl, —SO2OC1-6 alkyl, —OSO2C1-6 alkyl, —SOC1-6 alkyl, —Si(C1-6 alkyl)3, —OSi(C1-6 alkyl)3—C(?S)N(C1-6 alkyl)2, C(?S)NH(C1-6 alkyl), C(?S)NH2, —C(?O)S(C1-6 alkyl), —C(?S)SC1-6 alkyl, —SC(?S)SC1-6 alkyl, —P(?O)(OC1-6 alkyl)2, —P(?O)(C1-6 alkyl)2, —OP(?O)(C1-6 alkyl)2, —OP(?O)(OC1-6 alkyl)2, C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, C6-10 aryl, heterocyclyl, or heteroaryl; or two geminal Rgg substituents are joined to form ?O or ?S;
X? is a counterion;
each instance of the heteroaryl and heteroaryl ring independently is 5- to 10-membered, and monocyclic or bicyclic, and has ring carbon atoms and 1 to 4 ring heteroatoms;
each instance of the heterocyclyl and heterocyclic ring independently is 3- to 10-membered; saturated or partially unsaturated; non-aromatic; and monocyclic, fused bicyclic, bridged bicyclic, or spiro bicyclic; and has ring carbon atoms and 1 to 4 ring heteroatoms;
each instance of the ring heteroatoms is independently nitrogen, oxygen, or sulfur; and
each instance of the nitrogen protecting group is independently formamide, acetamide, chloroacetamide, trichloroacetamide, trifluoroacetamide, phenylacetamide, 3-phenylpropanamide, picolinamide, 3-pyridylcarboxamide, N-benzoylphenylalanyl, benzamide, p-phenylbenzamide, o-nitophenylacetamide, o-nitrophenoxyacetamide, acetoacetamide, (N?-dithiobenzyloxyacylamino)acetamide, 3-(p -hydroxyphenyl)propanamide, 3-(o-nitrophenyl)propanamide, 2-methyl-2-(o -nitrophenoxy)propanamide, 2-methyl-2-(o-phenylazophenoxy)propanamide, 4-chlorobutanamide, 3-methyl-3-nitrobutanamide, o-nitrocinnamide, N-acetylmethionine, o -nitrobenzamide, o-(benzoyloxymethyl)benzamide, methyl carbamate, ethylcarbamate, 9-fluorenylmethyl carbamate (Fmoc), 9-(2-sulfo)fluorenylmethyl carbamate, 9-(2,7-dibromo)fluoroenylmethyl carbamate, 2,7-di-t-butyl[9-(10,10-dioxo-10,10,10,10-tetrahydrothioxanthyl)]methyl carbamate (DBD-Tmoc), 4-methoxyphenacyl carbamate (Phenoc), 2,2,2-trichloroethyl carbamate (Troc), 2-trimethylsilylethyl carbamate (Teoc), 2-phenylethyl carbamate (hZ), 1-(1-adamantyl)-1-methylethyl carbamate (Adpoc), 1,1-dimethyl-2-haloethyl carbamate, 1,1-dimethyl-2,2-dibromoethyl carbamate (DB-t-BOC), 1,1-dimethyl-2,2,2-trichloroethyl carbamate (TCBOC), 1-methyl-1-(4-biphenylyl)ethyl carbamate (Bpoc), 1-(3,5-di-t-butylphenyl)-1-methylethyl carbamate (t-Bumeoc), 2-(2?- or 4?-pyridyl)ethyl carbamate (Pyoc), 2-(N,N-dicyclohexylcarboxamido)ethyl carbamate, t -butyl carbamate (BOC or Boc), 1-adamantyl carbamate (Adoc), vinyl carbamate (Voc), allyl carbamate (Alloc), 1-isopropylallyl carbamate (Ipaoc), cinnamyl carbamate (Coc), 4-nitrocinnamyl carbamate (Noc), 8-quinolyl carbamate, N-hydroxypiperidinyl carbamate, alkyldithio carbamate, benzyl carbamate (Cbz), p-methoxybenzyl carbamate (Moz), p-nitobenzyl carbamate, p-bromobenzyl carbamate, p-chlorobenzyl carbamate, 2,4-dichlorobenzyl carbamate, 4-methylsulfinylbenzyl carbamate (Msz), 9-anthrylmethyl carbamate, diphenylmethyl carbamate, 2-methylthioethyl carbamate, 2-methylsulfonylethyl carbamate, 2-(p-toluenesulfonyl)ethyl carbamate, [2-(1,3-dithianyl)]methyl carbamate (Dmoc), 4-methylthiophenyl carbamate (Mtpc), 2,4-dimethylthiophenyl carbamate (Bmpc), 2-phosphonioethyl carbamate (Peoc), 2-triphenylphosphonioisopropyl carbamate (Ppoc), 1,1-dimethyl-2-cyanoethyl carbamate, m-chloro-p-acyloxybenzyl carbamate, p -(dihydroxyboryl)benzyl carbamate, 5-benzisoxazolylmethyl carbamate, 2-(trifluoromethyl)-6-chromonylmethyl carbamate (Tcroc), m-nitrophenyl carbamate, 3,5-dimethoxybenzyl carbamate, o-nitrobenzyl carbamate, 3,4-dimethoxy-6-nitrobenzyl carbamate, phenyl(o-nitrophenyl)methyl carbamate, t-amyl carbamate, S-benzyl thiocarbamate, p-cyanobenzyl carbamate, cyclobutyl carbamate, cyclohexyl carbamate, cyclopentyl carbamate, cyclopropylmethyl carbamate, p-decyloxybenzyl carbamate, 2,2-dimethoxyacylvinyl carbamate, o-(N,N-dimethylcarboxamido)benzyl carbamate, 1,1-dimethyl-3-(N,N-dimethylcarboxamido)propyl carbamate, 1,1-dimethylpropynyl carbamate, di(2-pyridyl)methyl carbamate, 2-furanylmethyl carbamate, 2-iodoethyl carbamate, isoborynl carbamate, isobutyl carbamate, isonicotinyl carbamate, p-(p?-methoxyphenylazo)benzyl carbamate, 1-methylcyclobutyl carbamate, 1-methylcyclohexyl carbamate, 1-methyl-1-cyclopropylmethyl carbamate, 1-methyl-1-(3,5-dimethoxyphenyl)ethyl carbamate, 1-methyl-1-(p-phenylazophenyl)ethyl carbamate, 1-methyl-1-phenylethyl carbamate, 1-methyl-1-(4-pyridyl)ethyl carbamate, phenyl carbamate, p-(phenylazo)benzyl carbamate, 2,4,6-tri-t-butylphenyl carbamate, 4-(trimethylammonium)benzyl carbamate, 2,4,6-trimethylbenzyl carbamate, p -toluenesulfonamide (Ts), benzenesulfonamide, 2,3,6,-trimethyl-4-methoxybenzenesulfonamide (Mtr), 2,4,6-trimethoxybenzenesulfonamide (Mtb), 2,6-dimethyl-4-methoxybenzenesulfonamide (Pme), 2,3,5,6-tetramethyl-4-methoxybenzenesulfonamide (Mte), 4-methoxybenzenesulfonamide (Mbs), 2,4,6-trimethylbenzenesulfonamide (Mts), 2,6-dimethoxy-4-methylbenzenesulfonamide (iMds), 2,2,5,7,8-pentamethylchroman-6-sulfonamide (Pmc), methanesulfonamide (Ms), ?-trimethylsilylethanesulfonamide (SES), 9-anthracenesulfonamide, 4-(4?,8?-dimethoxynaphthylmethyl)benzenesulfonamide (DNMBS), benzylsulfonamide, trifluoromethylsulfonamide, phenacylsulfonamide, phenothiazinyl-(10)-acyl, N?-p -toluenesulfonylaminoacyl, N?-phenylaminothioacyl, N-benzoylphenylalanyl, N -acetylmethionine, 4,5-diphenyl-3-oxazolin-2-one, N-phthalimide, N-dithiasuccinimide (Dts), N-2,3-diphenylmaleimide, N-2,5-dimethylpyrrole, N-1,1,4,4-tetramethyldisilylazacyclopentane adduct (STABASE), 5-substituted 1,3-dimethyl-1,3,5-triazacyclohexan-2-one, 5-substituted 1,3-dibenzyl-1,3,5-triazacyclohexan-2-one, 1-substituted 3,5-dinitro-4-pyridone, N-methylamine, N-allylamine, N-[2-(trimethylsilyl)ethoxy]methylamine (SEM), N-3-acetoxypropylamine, N-(1-isopropyl-4-nitro-2-oxo-3-pyroolin-3-yl)amine, quaternary ammonium salt, N-benzylamine, N-di(4-methoxyphenyl)methylamine, N-5-dibenzosuberylamine, N-triphenylmethylamine (Tr), N -[(4-methoxyphenyl)diphenylmethyl]amine (MMTr), N-9-phenylfluorenylamine (PhF), N -2,7-dichloro-9-fluorenylmethyleneamine, N-ferrocenylmethylamino (Fcm), N-2-picolylamino N?-oxide, N-1,1-dimethylthiomethyleneamine, N-benzylideneamine, N-p -methoxybenzylideneamine, N-diphenylmethyleneamine, N-[(2-pyridyl)mesityl]methyleneamine, N-(N?,N?-dimethylaminomethylene)amine, N,N?-isopropylidenediamine, N-p-nitrobenzylideneamine, N-salicylideneamine, N-5-chlorosalicylideneamine, N-(5-chloro-2-hydroxyphenyl)phenylmethyleneamine, N -cyclohexylideneamine, N-(5,5-dimethyl-3-oxo-1-cyclohexenyl)amine, N-borane, N -diphenylborinic acid, N-[phenyl(pentaacylchromium- or tungsten)acyl]amine, N-copper chelate, N-zinc chelate, N-nitroamine, N-nitrosoamine, amine N-oxide, diphenylphosphinamide (Dpp), dimethylthiophosphinamide (Mpt), diphenylthiophosphinamide (Ppt), dialkyl phosphoramidate, dibenzyl phosphoramidate, diphenyl phosphoramidate, benzenesulfenamide, o-nitrobenzenesulfenamide (Nps), 2,4-dinitrobenzenesulfenamide, pentachlorobenzenesulfenamide, 2-nitro-4-methoxybenzenesulfenamide, triphenylmethylsulfenamide, or 3-nitropyridinesulfenamide (Npys).

US Pat. No. 10,112,956

HETEROCYCLIC COMPOUNDS HAVING CHOLESTEROL 24-HYDROXYLASE ACTIVITY

TAKEDA PHARMACEUTICAL COM...

8. A pharmaceutical composition comprising the compound or salt of claim 1 and a pharmacologically acceptable carrier.

US Pat. No. 10,112,955

ISOINDOLINE, AZAISOINDOLINE, DIHYDROINDENONE AND DIHYDROAZAINDENONE INHIBITORS OF MNK1 AND MNK2

eFFECTOR Therapeutics, In...

16. A pharmaceutical composition comprising (i) a therapeutically effective amount of at least one compound according to claim 1 or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof; (ii) in combination with a pharmaceutically acceptable carrier, diluent or excipient.

US Pat. No. 10,112,952

FUSED TETRA OR PENTA-CYCLIC DIHYDRODIAZEPINOCARBAZOLONES AS PARP INHIBITORS

BEIGENE, LTD., Grand Cay...

1. A method of treating a disease responsive to inhibition of PARP comprising administering to a subject in need thereof a compound of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit said PARP:wherein:RN is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
X is selected from the group consisting of C, N, O, and S;
m and n, which may be the same or different, are each an integer of 0, 1, 2, or 3;
t is an integer of 0, 1, 2, or 3;
R1, at each occurrence, is independently selected from halogen, CN, NO2, OR9, NR9R10, NR9COR10, NR9SO2R10, CONR9R10, COOR9, SO2R9, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
R2 is selected from hydrogen, COR9, CONR9R10, CO2R9, SO2R9, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
R3, R4, R5, R6, R7 and R8, which may be the same or different, are each independently selected from hydrogen, halogen, —NR9R10, —OR9, oxo, —COR9, —CO2R9, —CONR9R10, —NR9CONR10R11, —NR9CO2R10, —NR9SO2R10, —SO2R9, alkyl, alkenyl, cycloalkyl, aryl, heterocyclyl, alkynyl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, and heteroaryl is independently optionally substituted with at least one substituent R12,
or (R3 and R4), and/or (R4 and R5), and/or (R5 and R6), and/or (R6 and R7), and/or (R7 and R8), together with the atom(s) they are attached, form a 3- to 8-membered saturated, partially or fully unsaturated ring having 0, 1 or 2 heteroatoms independently selected from —NR13—, —O—, —S—, —SO— or —SO2—, and said ring is optionally substituted with at least one substituent R12,
provided that
when X is O, R5 and R6 are absent,
when X is N, R6 is absent,
when X is S, R5 and R6 are absent, or at least one of R5 and R6 is oxo,
when one of R3 and R4 is oxo, the other is absent,
when one of R7 and R8 is oxo, the other is absent, and
when X is C and one of R5 and R6 is oxo, the other is absent;
R9, R10, and R11, which may be the same or different, are each selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is independently optionally substituted with at least one substituent R12;
R12 is selected from CN, halogen, haloalkyl, NO2, —NR?R?, —OR?, oxo, —COR?, —CO2R?, —CONR?R?, —NR?CONR?R??, —NR?CO2R?, —NR?SO2R?, —SO2R?, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein R?, R?, and R?? are independently selected from hydrogen, haloalkyl, alkyl, arylalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or (R? and R?), and/or (R? and R??) together with the atoms to which they are attached, form a 3- to 8-membered saturated, partially or fully unsaturated ring having 0, 1 or 2 additional heteroatoms independently selected from —NR13—, —O—, —S—, —SO— and —SO2—; and
R13 is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl,
wherein the cycloalkyl is a hydrocarbon group selected from saturated and partially unsaturated cyclic hydrocarbon groups, comprising monocyclic, bicyclic and tricyclic groups, and comprising from 3 to 12 carbon atoms;
wherein the heteroaryl is a group selected from:
5- to 7-membered aromatic, monocyclic rings comprising at least one heteroatom selected from N, O, and S, with the remaining ring atoms being carbon;
8- to 12-membered bicyclic rings comprising at least one heteroatom selected from N, O, and S, with the remaining ring atoms being carbon and wherein at least one ring is aromatic and at least one heteroatom is present in the aromatic ring; and
11- to 14-membered tricyclic rings comprising at least one heteroatom selected from N, O, and S, with the remaining ring atoms being carbon and wherein at least one ring is aromatic and at least one heteroatom is present in an aromatic ring; and
wherein the heterocyclyl is a ring selected from 4- to 12-membered monocyclic, bicyclic and tricyclic, saturated and partially unsaturated rings, comprising at least one carbon atoms in addition to at least one heteroatom selected from oxygen, sulfur, and nitrogen,
wherein the disease is selected from ovarian cancer or breast cancer.

US Pat. No. 10,112,951

PDE1 INHIBITOR

Eli Lilly and Company, I...

1. A method of treating chronic kidney disease in a patient, comprising administering to a patient in need thereof an effective amount of a compound of the formula:

US Pat. No. 10,112,949

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Janssen Pharmaceutica NV,...

1. A compound of Formula (I)
or a stereoisomeric form thereof, wherein
R1 is phenyl or 2-pyridinyl, each of which is optionally substituted with one or more substituents each independently selected from the group consisting of halo, C1-4alkyl, monohalo-C1-4alkyl, polyhalo-C1-4alkyl, —C1-4alkyl-OH, —CN, —C1-4alkyl-O—C1-4alkyl, C3-7cycloalkyl, —O—C1-4alkyl, monohalo-C1-4alkyloxy, polyhalo-C1-4alkyloxy, SF5, C1-4alkylthio, monohalo-C1-4alkylthio and polyhalo-C1-4alkylthio;
R2 is phenyl or pyridinyl, each of which is optionally substituted with one or more substituents each independently selected from the group consisting of halo, C1-4alkyl, monohalo-C1-4alkyl, polyhalo-C1-4alkyl, —OH, —O—C1-4alkyl, —C1-4alkyl-O—C1-4alkyl, monohalo-C1-4alkyloxy, polyhalo-C1-4alkyloxy, —C1-4alkyl-OH and NR5aR5b;
wherein R5a and R5b are each independently selected from the group consisting of hydrogen or C1-4alkyl;
R3 is selected from the group consisting of hydrogen or C1-4alkyl;
R4 is selected from the group consisting of hydrogen, C1-4alkyl, monohalo-C1-4alkyl, polyhalo-C1-4alkyl, —C1-4alkyl-O—C1-4alkyl and —C1-4alkyl-OH;
or a N-oxide, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,947

SUBSTITUTED 6-AMINOPURINES FOR TARGETING HSP90

Duke University, Durham,...

1. A compound of formula (I):wherein:A is a heat shock protein 90 binding component of formula (III):

wherein:
R is alkylenyl or heteroalkylenyl;
each Y1 is independently —CH or —N;
each Z1 is taken together with the carbon atoms to which they are attached to form a heterocyclic ring;
Z2 is —H or halo;
Z3 is —CH2—, —S—, —O—or —NH—;
Z4 is —H or halo; and
is the point of attachment in formula (I);X1 is —NH—, —O—, —S—, —C(O)—or —S(O)2—;
L is a divalent linker of the following formula:
—(CH2)m—(OCH2CH2)n—O—(CH2)p—,
wherein:
m is 2 or 3;
n is 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20; and
p is 2 or 3;
X2 is —NR—, —O—, —S—, —C(O)—or —S(O)2—;
R is —H or a detection moiety; and
B is a detection moiety, an anti-cancer agent, or a heat shock protein 90 binding component of formula (II):

wherein:
R1 is —H or —C1-8-alkyl;
R2 is —H or —C1-8-alkyl;
Y is —CR3 or —N;
R3 is —H, —F or —OCH3;
R4 is —H, —F or —OCH3;
R5 is —H, —F or —OCH3;
R6 is —C1-8-alkyl, —C2-8-alkenyl, —C2-8-alkynyl, —C3-8-cycloalkenyl, —C3-8-cycloalkenyl-C1-8-alkyl, —C3-8-cycloalkyl, —C3-8-cycloalkyl-C1-8-alkyl, aryl, aryl-C1-8-alkyl, halo-C1-8-alkyl, heteroaryl, heteroaryl-C1-8-alkyl, heterocyclyl, heterocyclyl-C1-8-alkyl, or hydroxy-C1-8-alkyl;
R7 is —H or —C1-8-alkyl;
R8 is —H or —C1-8-alkyl; or
R7 and R8, taken together with the carbon atom to which they are attached, form a —C3-8-cycloalkyl;
X is —CR9 or —N;
R9 is —H or —C1-8-alkyl; and
is the point of attachment in formula (I); orB is a detection moiety, an anti-cancer agent, or a heat shock protein 90 binding component of formula (III):

wherein:
R is alkylenyl or heteroalkylenyl;
each Y1 is independently —CH or —N;
each Z1 is taken together with the carbon atoms to which they are attached to form a heterocyclic ring;
Z2 is —H or halo;
Z3 is —CH2—, —S—, —0—or —NH—;
Z4 is —H or halo; and
is the point of attachment in formula (I);wherein each detection moiety independently comprises a fluorophore or a radioactive compound;
wherein the fluorophore is a fluorescein, a rhodamine, a coumarin, a cyanine or a boron-dipyrromethene;
wherein the radioactive compound is a radioisotope; and
wherein the anti-cancer agent is an alkylating agent, an anti-epidermal growth factor receptor antibody, an anti-Her-2 antibody, an antimetabolite, a vinca alkaloid, an anthracycline, a platinum-based agent, a topoisomerase inhibitor, a taxane, an anti-cancer antibiotic, an immune cell antibody, an interferon, an interleukin, a heat shock protein 90 inhibitor, an anti-androgen, an anti-estrogen, an antihypercalcemia agent, an apoptosis inducer, an aurora kinase inhibitor, a Bruton's tyrosine kinase inhibitor, a calcineurin inhibitor, a Ca2+-calmodulin-dependent protein kinase II inhibitor, a CD45 tyrosine phosphatase inhibitor, a cell division cycle 25 phosphatase inhibitor, a checkpoint kinase inhibitor, a cyclooxygenase inhibitor, a cRAF kinase inhibitor, a cyclin dependent kinase inhibitor, a cysteine protease inhibitor, a deoxyribonucleic acid intercalator, a deoxyribonucleic acid strand breaker, an E3 ligase inhibitor, an epidermal growth factor pathway inhibitor, a farnesyltransferase inhibitor, a fetal liver kinase-1 inhibitor, a glycogen synthase kinase-3 inhibitor, a histone deacetylase inhibitor, an I-kappa B-alpha kinase inhibitor, an imidazotetrazinone, an insulin tyrosine kinase inhibitor, a c-Jun N-terminal kinase inhibitor, a mitogen-activated protein kinase inhibitor, a mouse double minute 2 inhibitor, an MEK inhibitor, a matrix metalloproteinase inhibitor, a mammalian target of rapamycin inhibitor, a nerve growth factor receptor tyrosine kinase inhibitor, a p38 mitogen-activated protein kinase inhibitor, a p56 tyrosine kinase inhibitor, a platelet-derived growth factor pathway inhibitor, a phosphatidylinositol 3-kinase inhibitor, a phosphatase inhibitor, a protein phosphatase inhibitor, a protein kinase C inhibitor, a protein kinase C delta kinase inhibitor, a polyamine synthesis inhibitor, a protein tyrosine phosphatase 1B inhibitor, a protein tyrosine kinase inhibitor, an SRC family tyrosine kinase inhibitor, a spleen tyrosine kinase inhibitor, a Janus tyrosine kinase inhibitor, a retinoid, a ribonucleic acid polymerase II elongation inhibitor, a serine/threonine kinase inhibitor, a sterol biosynthesis inhibitor, a vascular endothelial growth factor pathway inhibitor, alitretinon, altretamine, aminopterin, aminolevulinic acid, amsacrine, asparaginase, atrasentan, bexarotene, carboquone, demecolcine, efaproxiral, elsamitrucin, etoglucid, a Gliadel implant, hydroxycarbamide, leucovorin, lonidamine, lucanthone, masoprocol, methyl aminolevulinate, mitoguazone, mitotane, oblimersen, omacetaxine, pegaspargase, porfimer sodium, prednimustine, sitimagene ceradenovec, talaporfin, temoporfin, trabectedin or verteporfin.

US Pat. No. 10,112,944

HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TNF

Bristol-Myers Squibb Comp...

1. A compound of Formula (I)
or a salt thereof, wherein:
X is CR6 or N;
W is:
(i) —(CR3R3)1-4—; or
(ii) —(CR3R3)x—Y—(CR3R3)y—;
each Y is independently O, NR4, or S(O)p;
x is zero, 1, or 2;
y is 1, 2, or 3, provided that (x+y) is 1, 2, or 3;
R1 is C2-6 alkenyl substituted with zero to 6 R1a, C2-6 alkynyl substituted with zero to 4 R1a, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R2 is H, halo, —CN, —CF3, —OCF3, —NO2, C1-6 alkyl substituted with zero to 6 R1a, —(CRgRg)rORe, —(CRgRg)rNRcRc, —(CRgRg)rS(O)pRb, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic heteroaryl substituted with zero to 3 R1a);
each R3 is independently H, halo, —CN, —OH, —OCF3, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —(CRgRg)rC(O)Rb, —(CRgRg)rC(O)ORb, —(CRgRg)rC(O)NRcRc, —(CRgRg)rORe, —(CRgRg)rOC(O)Rb, —(CRgRg)rOC(O)NRcRc, —(CRgRg)rOC(O)ORd, —(CRgRg)rNRcRc, —(CRgRg)rNRbC(O)Rd, —(CRgRg)rNRbC(O)ORd, —(CRgRg)rNRbC(O)NRcRc, —(CRgRg)rNRbS(O)pRd, —(CRgRg)rS(O)pRb, —(CRgRg)rS(O)pNRcRc, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a); or two R3 along with the carbon atom to which they are attached form C?O, C?NORb, a spirocarbocyclyl group, or a spiroheterocyclyl group;
each R4 is independently H, C1-6 alkyl substituted with zero to 6 R1a, C3-7 cycloalkyl substituted with zero to 6 R1a, —C(O)Rb, —C(O)NRcRc, —C(O)ORb, —S(O)2Rb, —S(O)2NRcRc, —S(O)2ORb, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic heteroaryl substituted with zero to 3 R1a);
R5 is —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-10 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R6 is H, halo, or —CN;
R7 is H, halo, —CN, C1-6 alkyl, or C1-3 alkoxy;
each R1a is independently F, Cl, —CN, C1-6 alkyl substituted with zero to 6 Ra, C3-6 cycloalkyl substituted with zero to 6 Ra, C1-3 alkoxy substituted with zero to 6 Ra, C1-3 haloalkoxy, heterocycloalkyl substituted with zero to 6 Ra, aryl substituted with zero to 6 Ra, mono- or bicyclic heteroaryl substituted with zero to 6 Ra, —C(O)Rb, —C(O)ORb, —C(O)NRcRc, —OC(O)Rb, —OC(O)NRcRc, —OC(O)ORd, —NRcRc, —NRbC(O)Rd, —NRbC(O)ORd, —NRbS(O)pRd, —NRbC(O)NRcRc, —NRbS(O)pNRcRc, —S(O)pRb, —S(O)pNRcRc, or —C(O)NRb(CH2)1-3NRcRc;
each Ra is independently halo, —CN, —OH, —NH2, C1-3 alkyl, C1-3 fluoroalkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 fluoroalkoxy, —C(O)OH, —C(O)(C1-3 alkyl), —C(O)O(C1-4 alkyl), —OC(O)(C1-3 alkyl), —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —C(O)NH(C1-3 alkyl), —OC(O)NH(C1-3 alkyl), —NHC(O)NH(C1-3 alkyl), —C(?NH)(NH2), C3-7 carbocyclyl, aryl, 5-7 membered heterocyclyl, mono- or bicyclic heteroaryl, —O(aryl), —O(benzyl), —O(heterocyclyl), —S(C1-3 alkyl), —S(aryl), —S(heterocyclyl), —S(O)(aryl), —S(O)(heterocyclyl), —S(O)2(aryl), —S(O)2(heterocyclyl), —NHS(O)2(aryl), —NHS(O)2(heterocyclyl), —NHS(O)2NH(aryl), —NHS(O)2NH(heterocyclyl), —NH(aryl) —NH(heterocyclyl), —NHC(O)(aryl), —NHC(O)(C1-3 alkyl), —NHC(O)(heterocyclyl), —OC(O)(aryl), —OC(O)(heterocyclyl), —NHC(O)NH(aryl), —NHC(O)NH(heterocyclyl), —OC(O)O(C1-3 alkyl), —OC(O)O(aryl), —OC(O)O(heterocyclyl), —OC(O)NH(aryl), —OC(O)NH(heterocyclyl), —NHC(O)O(aryl), —NHC(O)O(heterocyclyl), —NHC(O)O(C1-3 alkyl), —C(O)NH(aryl), —C(O)NH(heterocyclyl), —C(O)O(aryl), —C(O)O(heterocyclyl), —N(C1-3 alkyl)S(O)2(aryl), —N(C1-3 alkyl)S(O)2(heterocyclyl), —N(C1-3 alkyl)S(O)2NH(aryl), —N(C1-3 alkyl)S(O)2NH(heterocyclyl), —N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)(aryl), —N(C1-3 alkyl)C(O)(heterocyclyl), —N(C1-3 alkyl)C(O)NH(aryl), —(CH2)0-3C(O)NH(heterocyclyl), —OC(O)N(C1-3 alkyl)(aryl), —OC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)O(aryl), —N(C1-3 alkyl)C(O)O(heterocyclyl), —C(O)N(C1-3 alkyl)(aryl), —C(O)N(C1-3 alkyl)(heterocyclyl), —NHS(O)2N(C1-3 alkyl)(aryl), —NHS(O)2N(C1-3 alkyl)(heterocyclyl), —NHP(O)2N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(heterocyclyl), or —Si(C1-3 alkyl)3;
each Rb is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rc is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf; or when attached to the same nitrogen, two Rc along with the nitrogen atom to which they are attached form 4-8 membered heterocyclic ring optionally substituted with Rg;
each Rd is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Re is independently H, C1-6 alkyl substituted with zero to 6 Rf, C1-3 haloalkyl, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rf is independently H, halo, —OH, —CN, C1-6 alkyl substituted with zero to 6 Ra, C1-3 alkoxy, C3-7 cycloalkyl substituted with zero to 6 Ra, heterocycloalkyl substituted with zero to 6 Ra, aryl substituted with zero to 3 Ra, or mono- or bicyclic heteroaryl substituted with zero to 3 Ra;
each Rg is independently H, F, —OH, —CN, C1-3 alkyl, —CF3, or phenyl;
each p is independently zero, 1, or 2; and
each r is independently zero, 1, 2, 3, or 4.

US Pat. No. 10,112,943

SUBSTITUTED IMIDAZOLES AS GAMMA SECRETASE MODULATORS

Janssen Pharmaceutica NV,...

8. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of a compound according to claim 1.

US Pat. No. 10,112,942

SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS

Array BioPharma Inc., Bo...

1. A compound of the Formula I:and pharmaceutically acceptable salts and solvates thereof, wherein:X1, X2, X3 and X4 are independently CH or N, wherein zero, one or two of X1, X2, X3 and X4 is N;
A is CN;
B is
(b) C1-C6 alkyl optionally substituted with 1-3 fluoros,
(c) hydroxyC2-C6 alkyl-, wherein the alkyl portion is optionally substituted with 1-3 fluoros or a C3-C6 cycloalkylidene ring,
(e) (C1-C6 alkoxy)C1-C6 alkyl- optionally substituted with 1-3 fluoros,
(f) (R1R2N)C1-C6 alkyl-, wherein said alkyl portion is optionally substituted with OH and wherein R1 and R2 are independently H or C1-C6 alkyl (optionally substituted with 1-3 fluoros);
(g) hetAr1C1-C3 alkyl-, wherein hetAr1 is a 5-6 membered heteroaryl ring having 1-3 ring heteroatoms independently selected from N, O and S and is optionally substituted with one or more independently selected C1-C6 alkyl substituents; or
(i) (hetCyca)C1-C3 alkyl-,
hetCyca- is a 4-6 membered heterocyclic ring having 1-2 ring heteroatoms independently selected from N and O and optionally substituted with one or more substituents independently selected from OH, C1-C6 alkyl (optionally substituted with 1-3 fluoros), hydroxyC1-C6 alkyl-, C1-C6 alkoxy, (C1-C6 alkyl)C(?O)—, (C1-C6 alkoxy)C1-C6 alkyl- and fluoro, or wherein hetCyca is substituted with oxo;
Ring D is (i) a saturated 4-7 membered heterocyclic ring having two ring nitrogen atoms, or (ii) a saturated 7-9 membered bridged heterocyclic ring having two ring nitrogen atoms and optionally having a third ring heteroatom which is oxygen, wherein each of said rings is optionally substituted with (a) one to four groups independently selected from halogen, OH, C1-C3 alkyl which is optionally substituted with 1-3 fluoros, or C1-C3 alkoxy which is optionally substituted with 1-3 fluoros, (b) a C3-C6 cycloalkylidene ring, or (c) an oxo group;
E is
(h) Ar1C1-C6 alkyl-,
(j) hetAr2C1-C6 alkyl-, wherein the alkyl portion is optionally substituted with 1-3 fluoros, or
(l) hetAr2C(?O)—,
Ar1 is phenyl optionally substituted with one or more substituents independently selected from the group consisting of halogen, CN, C1-C6 alkyl (optionally substituted with 1-3 fluoros), C1-C6 alkoxy (optionally substituted with 1-3 fluoros), ReRfN— wherein Re and Rf are independently H or C1-C6 alkyl, (RpRqN)C1-C6 alkoxy- wherein RP and Rq are independently H or C1-C6 alkyl, and (hetAra)C1-C6 alkyl- wherein hetAra is a 5-6 membered heteroaryl ring having 1-2 ring nitrogen atoms, or Ar1 is a phenyl ring fused to a 5-6 membered heterocyclic ring having 1-2 ring heteroatoms independently selected from N and 0; and
hetAr2 is a 5-6 membered heteroaryl ring having 1-3 ring heteroatoms independently selected from N, O and S or a 9-10 membered bicyclic heteroaryl ring having 1-3 ring nitrogen atoms, wherein hetAr2 is optionally substituted with one or more substituents independently selected from the group consisting of halogen, CN, C1-C6 alkyl (optionally substituted with 1-3 fluoros), C1-C6 alkoxy (optionally substituted with 1-3 fluoros), (C1-C6 alkoxy)C1-C6 alkyl-(optionally substituted with 1-3 fluoros), ReRfN— wherein Re and Rf are independently H or C1-C6 alkyl, OH, (C1-C6 alkoxy)C1-C6 alkoxy- and C3-C6 cycloalkyl.

US Pat. No. 10,112,941

TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS

Bristol-Myers Squibb Comp...

1. A method for treating cancer in a subject in need thereof, comprising administering an effective amount of a compound, of the formula
or a pharmaceutically acceptable salt thereof,
in combination with the administration of a therapeutically effective amount of one or more immuno-oncology agents.

US Pat. No. 10,112,940

HISTONE DEMETHYLASE INHIBITORS

Celgene Quanticel Researc...

1. A method of treating a histone demethylase-associated esophageal and breast cancer in a subject comprising administering a therapeutically effective dose of a compound of Formula (IIIa)
wherein the compound of Formula (IIIa) includes pharmaceutically acceptable salts thereof, wherein:
X is halogen and n is 0 or 1;
Y is hydrogen or C1-C3alkyl;
Z is halogen, —OH, —NH2, —CN, —SO2, CF3, alkyl, alkoxy, alkylamino, optionally substituted 3 membered carbocyclyl, optionally substituted 5-7 membered heterocyclyl comprising 1-2 heteroatoms selected from N or O, or 6 membered heteroaryl comprising 1 oxygen; and m is 0, 1, or 2.

US Pat. No. 10,112,937

P2X7 MODULATORS AND METHODS OF USE

Janssen Pharmaceutica NV,...

36. A pharmaceutical composition, comprising:(a) a therapeutically effective amount of at least one compound selected from compounds of Formula (IIa and IIb):

R3, R4 and R6 are independently H or C1-C3 alkyl;
R8 is phenyl or pyridyl, optionally substituted with zero to three Rm substituents wherein Rm is independently selected from the group consisting of: halo, C1-C3alkyl and perhaloalkyl;
R7 is (a) phenyl, optionally substituted with zero to two groups independently selected from the group consisting of halo and C1-C3alkyl, or
(b) heteroaryl, independently selected from the group consisting of:

wherein Rk is halo or C1-C3alkyl;
Rj is H or C1-C3alkyl; wherein C1-C3alkyl is optionally substituted with one halo substituent or one alkoxy substituent; and
n is an integer from 0-3; and
pharmaceutically acceptable salts of compounds of Formula (IIa and IIb); and
(b) at least one pharmaceutically acceptable excipient.

US Pat. No. 10,112,936

FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS

Bristol-Myers Squibb Comp...

1. A compound of Formula (V)
or its stereoisomers, tautomers, a pharmaceutically acceptable salts, or solvates thereof, wherein:
A is C3-7 cycloalkyl substituted with 0-1 R1 and 0-2 R2;

Z is —CH(R11)—;
L is —C(O)NH—;
R1 is, independently at each occurrence, —NH2, —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —C(?NH)NH2, —C(O)NR8R9, —S(O)pNR8R9, —(CH2)rNR7R8, —(CH2)rNR7C(O)ORa, —CH2N H2, —CH2NH(C1-3 alkyl), —CH2N(C1-3 alkyl)2, —CH2CH2NH2, —CH2CH2NH(C1-3 alkyl), —CH2CH2N(C1-3 alkyl)2, —CH(C1-4 alkyl)NH2, —C(C1-4 alkyl)2NH2, —C(?NR8a)NR7R8, —NHC(?NR8a)NR7R8, ?NR8, —NR8CR8(?NR8a), F, Cl, Br, I, OCF3, CF3, —(CH2)rORa, —(CH2)rSRa, CN, 1-NH2-1-cyclopropyl, or C1-6 alkyl substituted with 0-1 R1a;
R1a is H, —C(?NR8a)NR7R8, —NHC(?NR8a)NR7R8, —NR8CH(?NR8a), —NR7R8, —C(O)NR8R9, F, OCF3, CF3, ORa, SRa, CN, —NR9SO2NR8R9, —NR8SO2Rc, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, or —(CF2)rCF3;
R2 is, independently at each occurrence, H, ?O, F, Cl, Br, I, OCF3, CF3, CHF2, CN, NO2, ORa, SRa, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR7R8, —C(O)NR7R8, —NR7C(O)Rb, —S(O)2NR8R9, —NR8S(O)2Rc, —S(O)2Rc, —S(O)2Rc, C1-6 alkyl substituted with 0-2 R2a, C2-6 alkenyl substituted with 0-2 R2a, C2-6 alkynyl substituted with 0-2 R2a, —(CH2)r-C3-10 carbocycle substituted with 0-3 R2b, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R2b;
R2a is, independently at each occurrence, H, F, Cl, Br, I, ?O, ?NR8, CN, OCF3, CF3, ORa, SRa, —NR7R8, —C(O)NR8R9, —NR7C(O)Rb, —S(O)pNR8R9, —NR8SO2Rc, —S(O)Rc, or —S(O)2Rc;
R2b is, independently at each occurrence, H, F, C1, Br, I, ?O, ?NR8, CN, NO2, ORa, SRa, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR7R8, —C(O)NR7R8, —NR7C(O)Rb, —S(O)2NR8R9, —S(O)2R C, —NR8SO2NR8R9, NR8SO2Rc, —(CF2)rCF3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C1-4 haloalkyl, or C1-4 haloalkoxy;
alternately, when R1 and R2 groups are substituted on adjacent ring atoms, they can be taken together with the ring atoms to which they are attached to form a 5- to 7-membered carbocycle or heterocycle comprising: carbon atoms and 0-4 heteroatoms selected from N, O, and S(O)p, wherein said carbocycle or heterocycle is substituted with 0-2 R2b;
R3 is, independently at each occurrence, —(CH2)r-phenyl substituted with 0-3 R3a and 0-1 R3d, —(CH2)r-naphthyl substituted with 0-3 R3a and 0-1 R3d, —(CH2)r-indanyl substituted with 0-3 R3a and 0-1 R3d or —(CH2)r-5-10 membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, and substituted with 0-3 R3a and 0-1 R3d;
R3a is, independently at each occurrence, ?O, F, Cl, Br, I, OCF3, CF3, NO2, CN, —(CH2)rOR3b, —(CH2)rSR3b, —(CH2)rNR7R8, C(?NR8a)NR8R9, —NHC(?NR8a)NR7R8, —NR8CR8(?NR8a), —(CH2)rNR8C(O)R3b, ?NR8, —(CH2)rNR8C(O)R3b, —(CH2)rNR8C(O)2R3b, —(CH2)rS(O)pNR8R9, —(CH2)rNR8S(O)pR3c, —S(O)pR3c, —S(O)pR3c, —C(O)—C1-4 alkyl, —(CH2)rCO2R3 b, —(CH2)rC(O)NR8R9, —(CH2)rOC(O)NR8R9, —NHCOCF3, —NHSO2CF3, —SO2 NHR3b, —SO2NHCOR3c, —SO2NHCO2R3c, —CONHSO2R3c, —NHSO2R3c, —CONHOR3b, C1-4 haloalkyl, C1-4 haloalkoxy-, C1-6 alkyl substituted by R3d, C2-6 alkenyl substituted by R3d, C2-6 alkynyl substituted by R3d, C3-6 cycloalkyl substituted by 0-1 R3d, —(CH2)r—C3-10 carbocycle substituted with 0-3 R3d, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R3d;
alternately, when two R3a groups are located on adjacent atoms, they can be taken together with the atoms to which they are attached to form a C3-10 carbocycle substituted with 0-2 R3d or a 5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-2 R3d;
R3b is, independently at each occurrence, H, C1-6 alkyl substituted with 0-2 R3d, C2-6alkenyl substituted with 0-2 R3d, C2-6 alkynyl substituted with 0-2 R3d, —(CH2)r—C3-10 carbocycle substituted with 0-3 R3d, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R3d;
R3c is, independently at each occurrence, C1-6 alkyl substituted with 0-2 R3d, C2-6 alkenyl substituted with 0-2 R3d, C2-6 alkynyl substituted with 0-2 R3d, —(CH2)r—C3-10 carbocycle substituted with 0-3 R3d, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R3d;
R3d is, independently at each occurrence, H, ?O, —(CH2)rORa, F, Cl, Br, CN, NO2, —(CH2)rNR7R8, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR7C(O)Rb, —C(O)NR8R9, —SO2NR8R9, —NR8SO2NR8R9, —NR8SO2Rc, —S(O)pRc, —(CF2)rCF3, C1-6 alkyl substituted with 0-2 Re, C2-6 alkenyl substituted with 0-2 Re, C2-6 alkynyl substituted with 0-2 Re, —(CH2)r—C3-10 carbocycle substituted with 0-3 Rd, or —(CH2)r-5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 Rd;
R4 is H;
R7 is, independently at each occurrence, H, C1-6 alkyl, —(CH2)n-C3-10 carbocycle, —(CH2)n-(5-10 membered heteroaryl), —C(O)Rc, —CHO, —C(O)2Rc, —S(O)2Rc, —CONR8Rc, —OCONHRc, —C(O)O—(C1-4 alkyl)OC(O)—(C1-4 alkyl), or —C(O)O—(C1-4 alkyl)OC(O)—(C6-10 aryl); wherein said alkyl, carbocycle, heteroaryl, and aryl are optionally substituted with 0-2 Rf;
R8 is, independently at each occurrence, H, C1-6 alkyl, or —(CH2)r-phenyl, or —(CH2)n-5-10 membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p; wherein said alkyl, phenyl and heterocycle are optionally substituted with 0-2 Rf;
alternatively, R7 and R8, when attached to the same nitrogen, combine to form a 5- to 10-membered heterocyclic ring comprising carbon atoms and 0-2 additional heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-2 Rd;
R8a is, independently at each occurrence, H, OH, C1-6 alkyl, C1-4 alkoxy, (C6-10 aryl)-C1-4 alkoxy, —(CH2)n-phenyl, —(CH2)n-(5-10 membered heteroaryl), —C(O)Rc, —C(O)2Rc, —C(O)O—(C1-4 alkyl)OC(O)—(C1-4 alkyl), or —C(O)O—(C1-4 alkyl)OC(O)—(C6-10 aryl); wherein said phenyl, aryl, and heteroaryl is optionally substituted with 0-2 Rf;
R9 is, independently at each occurrence, H, C1-6 alkyl, or —(CH2)n-phenyl; wherein said alkyl and phenyl are optionally substituted with 0-2 Rf;
R9a is, independently at each occurrence, H, C1-6 alkyl, or —(CH2)n-phenyl;
alternatively, R8 and R9, when attached to the same nitrogen, combine to form a 5- to 10-membered heterocyclic ring comprising carbon atoms and 0-2 additional heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-2 Rd;
R11 is —CH2-phenyl;
Ra is, independently at each occurrence, H, CF3, C1-6 alkyl, —(CH2)r—C3-7 cycloalkyl, —(CH2)r—C6-10 aryl, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p; wherein said cycloalkyl, aryl and heteroaryl groups are optionally substituted with 0-2 Rf;
Rb is, independently at each occurrence, CF3, OH, C1-4 alkoxy, C1-6 alkyl, —(CH2)r—C3-10 carbocycle substituted with 0-3 Rd, or —(CH2)r-5-10 membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 Rd;
Rc is, independently at each occurrence, CF3, C1-6 alkyl substituted with 0-2 Rf, C3-6 cycloalkyl substituted with 0-2 Rf, C6-10 aryl, 5- to 10-membered heteroaryl, (C6-10 aryl)-C1-4 alkyl, or (5- to 10-membered heteroaryl)-C1-4 alkyl, wherein said aryl and heteroaryl groups are optionally substituted with 0-3 Rf;
Rd is, independently at each occurrence, H, ?O, ?NR8, ORa, F, Cl, Br, I, CN, NO2, —NR7R8, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR8C(O)Ra, —C(O)NR7R8, —SO2NR8SR9, —NR8SO2 NR8R9, —NR8SO2—C1-4 alkyl, —NR8SO2CF3, —NR8SO2-phenyl, —S(O)2CF3, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, —(CF2)rCF3, C1-6 alkyl substituted with 0-2 Re, C2-6 alkenyl substituted with 0-2 Re, or C2-6 alkynyl substituted with 0-2 Re;
Re is, independently at each occurrence, ?O, ORa, F, Cl, Br, I, CN, NO2, —NR8R9, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR8C(O)Ra, —C(O)NR7R8, —SO2NR8R9, NR8SO2NR8R9, —NR8SO2—C1-4 alkyl, —NR8SO2CF3, —NR8SO2-phenyl, —S(O)2CF3, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, or —(CF2)rCF3;
Rf is, independently at each occurrence, H, ?O, —(CH2)r—OR, F, Cl, Br, I, CN, NO2, —NR9aR9a, —C(O)R9, —C(O)ORg, —NR9aC(O)R9, —C(O)NR9aR9a, —SO2NR9aR9a, —NR9aSO2NR9aR9a, —NR9aSO2—C1-4 alkyl, —NR9aSO2CF3, —NR9aSO2-phenyl, —S(O)2CF3, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, —(CF2)rCF3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or —(CH2)n-phenyl;
Rg is, independently at each occurrence, H, C1-6 alkyl, or —(CH2)n-phenyl;
n, at each occurrence, is selected from 0, 1, 2, 3, and 4;
p, at each occurrence, is selected from 0, 1, and 2; and
r, at each occurrence, is selected from 0, 1, 2, 3, and 4.

US Pat. No. 10,112,935

INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE

Lycera Corporation, Ann ...

1. A compound represented by Formula I:
or a pharmaceutically acceptable salt thereof, or a solvate of the foregoing; wherein:
R1 and R4 each represent independently for each occurrence hydrogen, halogen, C1-C3 alkyl, C1-C3 haloalkyl, cyclopropyl, C2-C4 alkenyl, or cyano;
R2 and R3 each represent independently for each occurrence hydrogen, C1-C3 alkyl, cyclopropyl, or cyano;
R5 is hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, or —CO2R12;
R6 and R7 each represent independently for each occurrence hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, or C3-C6 cycloalkyl; or R6 and R7 when attached to the same nitrogen atom may be taken together with the nitrogen atom to form a 3-7 membered ring optionally substituted with 1 or 2 R12;
R8 and R9 each represent independently for each occurrence hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, C1-C3 haloalkyl, C3-C6 cycloalkyl, —(C1-C6 alkylene)-O—(C1-C6 alkyl), or —(C1-C6 alkylene)-N(R6)(R7); or R8 and R9 when attached to the same nitrogen atom may be taken together with the nitrogen atom to form a 3-7 membered ring optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C3-C6 cycloalkyl, C1-C6 alkoxyl, cyano, hydroxyl, —CO2R6, —C(O)N(R6)(R7), —N(R6)C(O)R6, —N(R6)2, and —(C1-C6 alkylene)-CO2R6;
R10 represents independently for each occurrence C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C1-C6 hydroxyalkyl, —(C1-C6 alkylene)-O—(C1-C6 alkyl), —(C1-C6 alkylene)-N(R8)(R9), —(C1-C6 alkylene)-CO2R6, —(C1-C6 alkylene)-(3-7 membered heterocycloalkyl), or 3-7 membered heterocycloalkyl; wherein said cycloalkyl is optionally substituted by 1 or 2 C1-C6 alkyl;
R11 represents independently for each occurrence a 5-6 membered heteroaryl or 3-7 membered heterocycloalkyl, each of which is optionally substituted with 1 or 2 occurrences of Y1;
R12 represents independently for each occurrence C1-C6 alkyl or C3-C6 cycloalkyl;
A1 is a cyclic group selected from:
or dihydropyridinyl, each being optionally substituted by X1 and 0, 1, 2, or 3 occurrences of Y1;(iii) a heteroaryl selected from the group consisting a 8-10 membered bicyclic heteroaryl, a 5-membered heteroaryl, and a 6-membered heteroaryl containing at least two ring nitrogen atoms; wherein said heteroaryl is optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of X1, Y1, —(C1-C6 alkylene)-CO2R8, —N(R6)(R7), —O-(3-7 membered heterocyclyl), a 3-7 membered heterocycloalkyl, and C6 aryl;
(iv) a 3-7 membered heterocycloalkyl, C3-C7 cycloalkyl, or 8-10 membered bicyclic partially unsaturated heterocyclyl, each optionally substituted by oxo, C6 aryl, X1, and 0, 1, 2, or 3 occurrences of Y1; or
(v) aralkyl or heteroaralkyl, each being optionally substituted by a C6 aryl, X1, and 0, 1, 2, or 3 occurrences of Y1;
X1 represents independently for each occurrence:
—N(R6)C(O)-(3-7 membered heterocyclyl), —N(R6)C(O)-phenyl, —N(R6)C(O)-aralkyl, or —N(R6)C(O)-heteroaralkyl; each of which is optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of Y1 and —N(R8)(R9);
—CO2R8, —C(O)N(R8)(R9), —C(O)R11, —C(O)R12, —C(O)-(3-7 membered heterocyclyl), —C(O)N(R8)(R10), —N(R6)C(O)R10, —N(R10)C(O)R10, —N(R6)CO2R10, —N(R8)SO2R10, —N(R6)—(C1-C6 alkylene)-C(O)N(R8)(R9), —N(R6)—C(O)—(C1-C6 hydroxyalkylene)-N(R8)(R9), —N(R6)—C(O)-(2-6 membered heteroalkyl), —N(R6)C(O)N(R6)(R7), or —NO2;
—O—(C1-C6 alkylene)-CO2R8, —OC(O)R12, —O—(C1-C6 alkylene)-C(O)N(R8)(R9), —O—(C1-C6 alkylene)-N(R8)(R9), —O—(C1-C6 alkyl), —O-(3-7 membered heterocyclyl), —O—(C1-C6 alkylene)-aryl, or —O—(C1-C6 alkylene)-heteroaryl;
—SO2R10, —SO2N(R8)-heteroaryl, cyano, or —P(O)(OR8)2;
5-6 membered heteroaryl, 3-7 membered heterocycloalkyl, 3-7 membered oxo-heterocycloalkyl, or 8-10 membered bicyclic heterocyclyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of phenyl, and —N(R6)(R7); or
—(C2-C6 alkylene)-aryl, —(C2-C6 alkylene)-heterocyclyl, or —(C1-C6 alkylene)-COR12;
Y1 represents independently for each occurrence halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C3-C6 cycloalkyl, C1-C6 alkoxyl, C2-C6 alkenyl, cyano, hydroxyl, —CO2R8, —C(O)N(R8)(R9), —N(R6)C(O)R10, —N(R6)C(O)N(R6)(R7), —(C1-C6 alkylene)-CO2R8, —(C1-C6 alkylene)-O—(C1-C6 alkyl), —(C1-C6 alkylene)-N(R6)(R7), —(C1-C6 alkylene)-N(R6)S(O)2R12, —(C1-C6 alkylene)-S—C(O)R12, —S—R12, or 3-7 membered heterocycloalkyl; and
m is 0, 1, 2, or 3.

US Pat. No. 10,112,932

BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE

Genentech, Inc., South S...

1. A process for the preparation of compound 8, having the structure:
or a stereoisomer, geometric isomer, tautomer, or pharmaceutically acceptable salt thereof, wherein:
R1 is selected from the group consisting of —CH3, —CH2CH3, cyclopropyl, and cyclobutyl;
R2 is selected from the group consisting of —CH3, —CHF2, —CH2F, and —CF3;
comprising reacting compound 7, having the structure:

with an amino acid of formula H2NCH(R1)CO2H and a copper catalyst, followed by ammonium chloride, and HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate) to form 8.

US Pat. No. 10,112,931

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH

NOVARTIS AG, Basel (CH)

1. A compound according to formula (V)
wherein:
R2a is methyl or C1-3 haloalkyl;
R5 and R6 are each independently hydrogen, deuterium, halo, —C(O)OCH3, C1-3 alkyl or C1-3 haloalkyl;
R7 is

wherein:
ring A is a 6 membered heteroaryl ring having one to three nitrogen atoms;
ring B is a 5 membered heteroaryl ring having one to four heteroatoms each independently selected from the group consisting of N, O and S;
each R8 is independently hydrogen, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy or C1-3 haloalkoxy;
n is 1 or 2;
R9 is hydrogen, halo, C1-3 haloalkyl, optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted aryl, optionally substituted 5 or 6 membered heterocyclic, optionally substituted heteroaryl, —OR9a, —SO2R9a, C(O)NHR9a, CH2R9b or CHCH3R9b, wherein:
said C1-6 alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of: OH, phenyl and phenoxy, and
said C3-6 cycloalkyl, 5 or 6 membered heterocyclic, aryl and heteroaryl are each optionally substituted with one to three substituents each independently selected from the group consisting of: halo, hydroxyl, cyano, NRR, C1-6 alkyl, C1-6 haloalkyl, C1-3 alkoxy, and C1-3 haloalkoxy;
R9a is optionally substituted C1-6 alkyl, C1-6 haloalkyl, optionally substituted C3-6 cycloalkyl, optionally substituted phenyl, or optionally substituted heterocyclic,
wherein:
said C1-6 alkyl is optionally substituted with one C3-6 cycloalkyl,
said C3-6 cycloalkyl and heterocyclic are each optionally substituted with one to three substituents each independently selected from the group consisting of: hydroxyl, CH2OH, —NRR, cyano, C1-3 alkyl, C1-3 haloalkyl, and C1-3 alkoxy, and
said phenyl is optionally substituted with one to three substituents each independently selected from the group consisting of: halo, hydroxyl, cyano, NRR, C1-6 alkyl, C1-6 haloalkyl, C1-3 alkoxy, and C1-3 haloalkoxy;
R9b is optionally substituted C3-6 cycloalkyl, optionally substituted phenyl or optionally substituted heterocyclic,
said C3-6 cycloalkyl and heterocyclic are each optionally substituted with one to four substituents each independently selected from the group consisting of: hydroxyl, CH2OH, —NRR, —NRC(O)CH3, 4 to 6 membered heterocyclic, cyano, halo, C1-3 alkyl, C1-3 haloalkyl, and C1-3 alkoxy, and said phenyl is optionally substituted with one to three substituents each independently selected from the group consisting of: halo, hydroxyl, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-3 alkoxy, and C1-3 haloalkoxy; and
each R is independently selected from the group consisting of H, C1-3 alkyl and C3-6 cycloalkyl; or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,926

AMINO PYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

Novartis AG, Basel (CH)

1. A compound of formula (I)
or a pharmaceutically acceptable salt thereof, wherein
E is selected from N and CRE;
R1, R2 and RE are independently selected from H, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 hydroxyalkyl and C3-7 cycloalkyl;
R3 is selected from
(i) C1-4 alkyl which is unsubstituted or substituted with 1 or more substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 haloalkyl, C1-4 alkoxy, C1-4 alkyl, oxo, CN, —(C0-3 alkyl)-NR3aR3b, C3-7 cycloalkyl and C3-7 heterocyclyl, and wherein the C3-7 cycloalkyl or C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(ii) C1-4 alkoxy which is unsubstituted or substituted with 1 or more substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 haloalkyl, C1-4 alkoxy, C1-4 alkyl, oxo, CN, —(C0-3 alkyl)-NR3aR3b, C3-7 cycloalkyl and C3-7 heterocyclyl, and wherein the C3-7 cycloalkyl or C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(iii) —C3-7 cycloalkyl or —O—C3-7 cycloalkyl wherein the C3-7 cycloalkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(iv) —(C0-3 alkyl)-C3-7 cycloalkyl or —O—(C0-3 alkyl)-C3-7 cycloalkyl wherein the C3-7 cycloalkyl is spiro fused to a second C3-7 cycloalkyl or C3-7 heterocyclyl by one single carbon atom, and wherein the C3-7 cycloalkyl or C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(v) —(C0-3 alkyl)-C3-7 heterocyclyl or —O—(C0-3 alkyl)-C3-7 heterocyclyl, and wherein said C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(vi) —(C0-3 alkyl)-C3-7 heterocyclyl or —O—(C0-3 alkyl)-C3-7 heterocyclyl, and wherein said C3-7 heterocyclyl is spiro fused to a second C3-7 heterocyclyl or a C3-7 cycloalkyl by one single carbon atom, and wherein the C3-7 heterocyclyl or C3-7 cycloalkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(vii) pyridyl wherein the pyridyl is unsubstituted or substituted with 1 to 3 substituents independently selected from C1-4 alkyl, C1-4 alkoxy, hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 haloalkyl and —(C0-3 alkyl)-NR3aR3b; and
(viii) H;
R4 is selected from H and C1-4 alkyl; or
R3 and R4 together with the nitrogen atom to which they are attached form a C3-7 heterocyclyl, which C3-7 heterocyclyl is optionally spiro fused to a second C3-7 heterocyclyl or a C3-7 cycloalkyl by one single carbon atom, and which C3-7 heterocyclyl and C3-7 cycloalkyl are unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
R3a and R3b are independently selected from H, C1-4 alkyl and C1-4 haloalkyl;
Y is selected from the group consisting of
oxazol-5-yl,
thiazol-5-yl,
thiazol-4-yl,
isothiazol-5-yl,
pyrazol-4-yl,
pyrazol-1-yl,
pyrid-4-yl,
1,2,4-triazol-1-yl,
1,2,3-triazol-4-yl,
1,2,4-oxadiazol-5-yl,
1,3,4-oxadiazol-2-yl,
isoxazol-5-yl,
isoxazol-4-yl, and
pyrrol-3-yl,
each of which is unsubstituted or substituted with 1 to 3 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, —(C?O)—C3-7 heterocyclyl, —(C0-3 alkyl)-NR?R? and —(C?O)—NR?R?; and
R? and R? are independently selected from H and C1-4 alkyl;
or a pharmaceutically acceptable salt thereof.