US Pat. No. 10,793,972

HIGH QUALITY SILICON CARBIDE CRYSTALS AND METHOD OF MAKING THE SAME

II-VI Delaware, Inc., Wi...

1. A physical vapor transport (PVT) apparatus for growing SiC boules, comprising:a crystal growth chamber defined as having a central vertical axis;
a sealed crucible disposed within the crystal growth chamber and configured to support a quantity of sublimation source material disposed in a lower region thereof, the sealed crucible further comprising
a seed fixture disposed above the lower region and disposed in an offset position
with respect to the central vertical axis of the crystal growth chamber; and
a heat source disposed to surround the crystal growth chamber and configured to raise a temperature within the sealed crucible such that the source material vaporizes and deposits on a seed wafer included within the seed fixture, the offset position of the seed fixture providing a radial temperature gradient across an exposed surface thereof.

US Pat. No. 10,793,971

METHOD AND APPARATUS FOR PRODUCING BULK SILICON CARBIDE USING A SILICON CARBIDE SEED

GTAT Corporation, Merrim...

1. A method of forming silicon carbide comprising:i) providing a sublimation furnace comprising a furnace shell, at least one heating element positioned outside the furnace shell, and a hot zone positioned inside the furnace shell surrounded by insulation, the hot zone comprising:
a) a crucible having an upper region and a lower region;
b) a crucible cover sealing the crucible; and
c) a silicon carbide precursor positioned in the lower region of the crucible;
ii) preparing, outside of the crucible, a seed module with a seed holder holding a silicon carbide seed therein, wherein the seed holder includes a plurality of vapor release openings positioned around a center axis of the seed holder;
iii) disposing the silicon carbide seed within the seed module between an upper section and a lower section of the seed holder while the seed module is outside of the crucible, wherein the silicon carbide seed includes a top surface and a bottom surface, and wherein the plurality of vapor release openings are formed in the upper section of the seed holder below the bottom surface of silicon carbide seed;
iv) after disposing the silicon carbide seed within the seed module while the seed module is outside of the crucible, disposing the seed module containing the silicon carbide seed therein in the upper region of the crucible;
v) heating the hot zone with the at least one heating element to sublimate the silicon carbide precursor; and
vi) forming the silicon carbide on the bottom surface of the silicon carbide seed while the top surface of the silicon carbide seed is exposed.

US Pat. No. 10,793,970

METHOD OF FABRICATING A TURBINE ENGINE PART

SAFRAN AIRCRAFT ENGINES, ...

1. A method of fabricating a turbine engine part, the method comprising:fabricating an ingot out of ceramic material of eutectic composition by performing the Czochralski process comprising the following steps:
putting a seed of the ingot that is to be obtained into contact with a molten bath of a mixture of eutectic composition in order to initiate the formation of the ingot on the seed, said mixture comprising at least two ceramic compounds;
drawing the ingot from the molten bath while imposing on the ingot that is being formed a drawing speed less than or equal to 10 mm/h together with rotation at a speed of rotation less than or equal to 50 rpm; and
machining the ingot as fabricated in this way in order to obtain the turbine engine part,
wherein the ingot is drawn from the molten bath along a drawing axis, and wherein a temperature gradient less than or equal to 50° C./mm is maintained in the ingot along the drawing axis, at least in the vicinity of a surface of the molten bath.

US Pat. No. 10,793,969

SAMPLE ROD GROWTH AND RESISTIVITY MEASUREMENT DURING SINGLE CRYSTAL SILICON INGOT PRODUCTION

GlobalWafers Co., Ltd., ...

1. A method for producing a single crystal silicon ingot from a silicon melt held within a crucible comprising:adding polycrystalline silicon to the crucible;
heating the polycrystalline silicon to cause a silicon melt to form in the crucible;
pulling a sample rod from the melt, the sample rod having a diameter;
annealing the sample rod to annihilate thermal donors;
measuring a resistivity of the sample rod after annihilation of thermal donors; and
pulling a product ingot from the melt, the product ingot having a diameter, the diameter of the sample rod being less than the diameter of the product ingot.

US Pat. No. 10,793,968

METHOD OF PRODUCTION OF LANGATATE-BASED SINGLE CRYSTAL AND LANGATATE-BASED SINGLE CRYSTAL

CITIZEN FINEDEVICE CO., L...

1. A method of production of a langatate-based single crystal using the Czochralski method of pulling up a crystal from a starting material solution so as to grow a langatate-based single crystal having an insulation resistance at 500° C. of 3.0×109 ?·cm or more and a compressive fracture strength in the X-axial direction at 200° C. of 1500 MPa or more,wherein an atmospheric gas growing said langatate-based single crystal is a mixed gas comprised of an inert gas in which an amount of an oxidizing gas is in a range of 6-15 vol %.

US Pat. No. 10,793,967

SUBSTRATE HOLDER AND PLATING APPARATUS USING THE SAME

EBARA CORPORATION, Tokyo...

1. A substrate holder, comprising:a first holding member having a first surface that contacts with a substrate; and
a second holding member being attachable to the first holding member to sandwich the substrate between the first holding member and the second holding member,
wherein a positioning member is provided on the first holding member and configured to position the substrate which is in contact with the first surface, the positioning member comprising an extension that contacts a peripheral edge part of the substrate when the substrate is at a prescribed position of the first surface,
wherein the positioning member is configured to move between a first position where the substrate is to be positioned at the prescribed position of the first surface and the positioning member is in contact with the peripheral edge part of the substrate, and a second position not in contact with the substrate, the positioning member positioning the substrate by contacting with the second holding member and the peripheral edge part of the substrate to move toward an inside of the substrate in a radial direction,
wherein a driving member is provided on the second holding member and comprises a surface configured to cause the positioning member to be positioned at the first position, at the time when holding the substrate by the first holding member and the second holding member,
wherein the positioning member has a tip part,
wherein the tip part diverges into a first tip part and a second tip part,
wherein the first tip part is positioned at an inner side in a radial direction of the substrate, in a state where the substrate is held by the first holding member and the second holding member,
wherein the second tip part is positioned at an outer side in a radial direction of the substrate in a state where the substrate is held by the first holding member and the second holding member,
wherein the first tip part is configured to contact with the substrate, and
wherein the second tip part is configured to contact with the driving member.

US Pat. No. 10,793,966

HIERARCHICALLY STRUCTURED DUPLEX ANODIZED ALUMINUM ALLOY

Raytheon Technologies Cor...

1. A component, comprising:an aluminum alloy substrate;
a stepped growth Tartaric-Sulfuric Acid (TSA) film on the substrate, wherein the stepped growth TSA film is a porous film comprising alternating TSA layers of a first layer having a first density and a second layer having a second density different from the first density; and
a phosphoric acid anodizing (PAA) film layer on the stepped growth TSA film.

US Pat. No. 10,793,965

LIGHT-DIRECTED ELECTROCHEMICAL PATTERNING OF COPPER STRUCTURES

Board Of Trustees Of The ...

1. A method of creating a patterned film with cuprous oxide (Cu2O) and light comprising the steps of:(a) electrodepositing cuprous oxide from a solution comprising copper ions onto a substrate;
(b) illuminating selected areas of said deposited cuprous oxide with light having photon energies above the band gap energy of 2.0 eV to create selected illuminated sections and non-illuminated sections; and
(c) stripping cuprous oxide from said non-illuminated sections leaving said deposited cuprous oxide on said illuminated sections of the substrate.

US Pat. No. 10,793,964

PRE-TREATED FUNCTIONALIZED MULTI-WALLED CARBON NANOTUBE BASED METHANE SENSOR

UChicago Argonne, LLC, C...

1. A process for manufacturing a chemresistor comprising:fabricating electrodes on a substrate;
depositing carbon nanotubes on the fabricated electrodes;
pre-treating the carbon nanotubes for 1-20 minutes with ozone and UV to induce surface defects; and
depositing by atomic layer deposition, a plurality of nanoparticles consisting of a metal oxide functionalizing agent on the surface defects.

US Pat. No. 10,793,963

PASSIVATING FISSURES IN SUBSTRATES

ILLUMINA, INC., San Dieg...

1. A method, comprising:passivating at least one fissure in a passivation layer of a sensor, the sensor comprising a metal containing layer, the passivation layer disposed over the metal containing layer, and a structure forming a flow channel above a top active surface of the passivation layer, a top portion of the structure including an electrode, wherein the passivating comprises:
applying an aqueous solution comprising a polymer precursor and an electrolyte to the flow channel of the structure;
applying a first voltage to the metal containing layer of the sensor;
applying a second voltage to the electrode, the second voltage being a voltage of an opposite polarity to the first voltage; and
forming a polymer formation extending up from the metal containing layer at the at least one fissure to a top surface of the passivation layer.

US Pat. No. 10,793,962

AQUEOUS INDIUM OR INDIUM ALLOY PLATING BATH AND PROCESS FOR DEPOSITION OF INDIUM OR AN INDIUM ALLOY

Atotech Deutschland GmbH,...

1. A process for deposition of indium or an indium alloy comprising the steps of:i. providing a substrate (100) having at least one metal or metal alloy surface;
ii. contacting the at least one surface of said substrate (100) with an aqueous indium or indium alloy plating bath comprising:
a source of indium ions,
an acid,
a source of halide ions,
a surfactant according to formula (I)

wherein A is selected from branched or unbranched C10-C15-alkyl;
B is selected from the group consisting of hydrogen and alkyl;
m is an integer ranging from 5 to 25;
each R is independently from each other selected from hydrogen and methyl; and
a dihydroxybenzene derivative according to formula (II)

wherein each X is independently selected from fluorine, chlorine, bromine, iodine, alkoxy, and nitro;
n is an integer ranging from 1 to 4,
wherein, when the aqueous indium or indium alloy plating bath is an indium alloy plating bath, an alloying reducible metal is selected from the group consisting of aluminum, bismuth, copper, gold, lead, nickel, silver, tin, tungsten and zinc;
and thereby depositing an indium layer or indium alloy layer on at least a portion of the at least one surface, and
wherein
in step ii. the indium or indium alloy layer is a first indium or indium alloy layer (101),
in step ii. a composed phase (102) is formed, made of the metal or metal alloy of said surface (100a) and at least a part of the first indium or indium alloy layer (101),
wherein the process further comprises the steps:
iii. removing partially or wholly the part of the first indium or indium alloy layer which has not been converted into the composed phase (103); and
iv. depositing a second indium or indium alloy layer (104) on at least a portion of the surface obtained in step iii (102a).

US Pat. No. 10,793,959

METHOD FOR PRODUCTION OF METAL ARTICLE OF MANUFACTURE AND USES THEREOF

1. A method for making a porous silver metal article of manufacture comprising:(a) forming a saturated aqueous solution of silver, wherein the silver is a donor;
(b) subjecting the solution to electrolysis to form dendrite crystals of silver or silver nanowires, wherein both an anode and a cathode are made of silver,
(c) harvesting the dendrite crystals of silver or silver nanowires from the bottom of the solution;
(d) pressing the collected dendrite crystals into a geometric shape;
(e) sintering the geometric shape at about 300° F. followed by at about 600° F. for about 15 min to about 60 min;
(f) cooling the sintered geometric shape at room temperature, to room temperature; and
(g) pressing or packing the cooled geometric shape to form the porous silver metal article of manufacture.

US Pat. No. 10,793,958

SYSTEM AND METHOD FOR PARALLEL SOLUTION EXTRACTION OF ONE OR MORE METAL VALUES FROM METAL-BEARING MATERIALS

FREEPORT MINERALS CORPORA...

1. A system for extracting metal value comprising:a solution extraction system comprising a first circuit and a second circuit,
wherein the first circuit is configured to receive a first portion of a first metal bearing solution comprising copper and cobalt, and to produce a first copper-rich electrolyte;
wherein the second circuit is configured to receive a second portion of the first metal bearing solution and to produce a second copper-rich electrolyte; and
wherein the first circuit is configured to receive a second metal bearing solution comprising copper and cobalt and to produce a cobalt-containing raffinate;
a primary metal value recovery system configured to extract copper from the first copper-rich electrolyte and the second copper-rich electrolyte; and
a secondary metal value recovery system configured to extract cobalt from the cobalt-containing raffinate.

US Pat. No. 10,793,957

CLOSED LOOP SYSTEMS AND METHODS FOR RECYCLING LEAD ACID BATTERIES

AQUA METALS INC., Alamed...

1. A method of electrochemically producing high-purity lead, comprising:desulfating lead paste using an alkaline process, wherein the desulfating further includes a step of reacting the lead paste or desulfated lead paste with hydrogen peroxide to reduce lead dioxide to lead oxide and to so generate a lead oxide-containing desulfated lead paste;
dissolving the lead oxide-containing desulfated lead paste in a methane sulfonic acid solvent to so form an acidic lead ion-enriched electroprocessing solvent, and contacting the lead ion-enriched electroprocessing solvent with a cathode and an anode, wherein the cathode has a surface comprising aluminum, an aluminum alloy, or an aluminum powder embedded in plastic and at least a portion of the cathode comprises a passivation layer, wherein the passivation layer is at least 0.1 ?m thick;
reducing lead ions in the lead ion-enriched electroprocessing solvent on the cathode under conditions effective to form adherent high-purity lead and a regenerated electroprocessing solvent;
removing the adherent high-purity lead from one portion of the cathode while lead ions are reduced on another portion of the cathode, wherein the high-purity lead has a purity of at least 98%; and
using at least some of the regenerated electroprocessing solvent in the step of dissolving the lead oxide-containing desulfated lead paste as the acidic electroprocessing solvent.

US Pat. No. 10,793,956

ADDITIVE FOR HIGH-PURITY COPPER ELECTROLYTIC REFINING AND METHOD OF PRODUCING HIGH-PURITY COPPER

MITSUBISHI MATERIALS CORP...

1. An additive for high-purity copper electrolytic refining which is an additive to be added to a copper electrolyte in electrolytic refining for producing high-purity copper, the additive consisting essentially of:a main agent formed of a non-ionic surfactant which has a hydrophobic group containing an aromatic ring and a hydrophilic group containing a polyoxyalkylene group; and
a stress relaxation agent formed of a polyvinyl alcohol or a derivative thereof,
wherein the main agent is one or more selected from the group consisting of compounds represented by Formulae [1] and [2],

where n of Formulae [1] and [2] is an added number of moles of a polyoxyethylene group, and n is 2 to 20.

US Pat. No. 10,793,955

DIGITALLY CONTROLLED CORROSION PROTECTION SYSTEM AND METHOD

FREEMAN INDUSTRIES, Chey...

1. An apparatus for controlling corrosion of a plurality of tanks each containing electrolyte, the apparatus comprising:an external power supply;
a plurality of electrodes, each immersed in the electrolyte in one of the plurality of tanks and coupled to the external power supply;
a plurality of reference cells, each immersed in the electrolyte in one of the plurality of tanks;
a plurality of control circuits, each coupled to one of the reference cells; and
a digital controller configured to, for each of the reference cells, individually control the coupled control circuit to control current applied to each of the electrodes by:
instructing each control circuit to simultaneously and independently:
measure and store a reference voltage between the coupled reference cell and the corresponding tank at a time when no electrical current is flowing through the corresponding electrode;
compare the measured reference voltage with a preset target voltage for the coupled reference cell;
apply a pulse width modulated electrical current through the corresponding electrode;
stop the pulse width modulated electrical current to measure and store a new measured reference voltage; and
incrementally adjust the pulse width modulated electrical current based on the comparison of the measured reference voltage to the preset target voltage of the coupled reference cell in discrete steps; and
instructing each control circuit to repeat the steps of measuring, comparing, applying, stopping, and incrementally adjusting the pulse width modulated electrical current until its measured reference voltage equals its preset target voltage.

US Pat. No. 10,793,954

PECVD PROCESS

Applied Materials, Inc., ...

1. A lid for a semiconductor processing apparatus, the lid comprising:a gas distributor having a plurality of gas flow openings formed therethrough;
a metrology device that directs and receives light through one of the gas flow openings, wherein the metrology device comprises a collimator with a fiber optic light source;
a first plate coupled to the gas distributor, wherein the collimator is disposed through an opening in the first plate, and the opening provides a gap that allows lateral motion of the collimator; and
a seating plate between the first plate and the gas distributor, the seating plate comprising a recess aligned with the gas flow opening, wherein the collimator is seated in the recess.

US Pat. No. 10,793,953

ACTIVATED GAS GENERATION APPARATUS AND FILM-FORMATION TREATMENT APPARATUS

TOSHIBA MITSUBISHI-ELECTR...

1. An activated gas generation apparatus comprising:a first electrode constituent part;
a second electrode constituent part provided below said first electrode constituent part; and
an AC power supply part applying an AC voltage to said first and second electrode constituent parts,
said AC power supply part applying said AC voltage to form a discharge space between said first and second electrode constituent parts, and to generate an activated gas obtained by activating a source gas supplied to said discharge space,
wherein:
said first electrode constituent part includes a first dielectric electrode and a first metal electrode selectively formed on an upper surface of said first dielectric electrode;
said second electrode constituent part includes a second dielectric electrode and a second metal electrode selectively formed on a bottom surface of said second dielectric electrode;
a space where said first and second dielectric electrodes face each other is defined as a dielectric space, a region in said dielectric space where said first and second metal electrodes overlap each other in plan view is defined as said discharge space;
said second metal electrode includes a pair of second partial metal electrodes formed so as to face each other with a central region of said second dielectric electrode interposed therebetween in plan view, and said pair of second partial metal electrodes have a first direction as an electrode formation direction and a second direction intersecting with said first direction, the pair of second partial metal electrodes facing each other along said second direction;
said first metal electrode includes a pair of first partial metal electrodes including a region overlapping with said pair of second partial metal electrodes in plan view, and
said second dielectric electrode includes a gas spray hole in said central region for spraying said activated gas to an outside, and a central region step part protrudes upward in said central region; and
said central region step part has a shorter width in said second direction as approaching said gas spray hole in plan view without overlapping with said gas spray hole in plan view.

US Pat. No. 10,793,952

METHOD FOR FORMING SEALING FILM, AND SEALING FILM

TORAY ENGINEERING CO., LT...

1. A sealing film formed by alternately forming a buffer layer and a barrier layer whose density is higher than that of the buffer layer on a substrate having a stepped portion on an upper surface of the substrate, the upper surface of the substrate facing in a thickness direction of the substrate, the stepped portion having a side surface facing in an inclined direction that is inclined with respect to the thickness direction, the sealing film comprising:a first buffer layer disposed on the substrate, the first buffer layer having
a first part that is disposed on the upper surface of the substrate and has a first constant thickness measured between the upper surface of the substrate and an upper surface of the first part in the thickness direction, with the upper surface of the first part being parallel to the upper surface of the substrate, and
a second part that is disposed on the side surface of the stepped portion and has a second constant thickness measured between the side surface of the stepped portion and a side surface of the second part in the inclined direction, with the side surface of the second part being parallel to the side surface of the stepped portion;
a first barrier layer disposed on the first buffer layer, the first barrier layer having
a third part that is disposed on the upper surface of the first part of the first buffer layer, the third part having an upper surface that is parallel to the upper surface of the substrate, and
a fourth part that is disposed on the side surface of the second part, the fourth part having a side surface that is parallel to the side surface of the stepped portion; and
a second buffer layer made of the same raw material as the first buffer layer and disposed on the first barrier layer, the second buffer layer having
a fifth part that is disposed on the upper surface of the third part of the first barrier layer and has a third constant thickness measured between the upper surface of the third part of the first barrier layer and an upper surface of the fifth part in the thickness direction, with the upper surface of the fifth part being parallel to the upper surface of the stepped portion, and
a sixth part that is disposed on the side surface of the fourth part of the first barrier layer and has a fourth constant thickness measured between the side surface of the fourth part of the first barrier layer and a side surface of the sixth part in the inclined direction, with the side surface of the sixth part being parallel to the side surface of the stepped portion,
a ratio of the first constant thickness of the first buffer layer in the thickness direction relative to the second constant thickness of the first buffer layer in the inclined direction being closer to 1 than a ratio of the third constant thickness of the second buffer layer in the thickness direction relative to the fourth constant thickness of the second buffer layer in the inclined direction,
the first barrier layer having density that is higher than those of the first and second buffer layers, with the first barrier layer being made of different raw material from that of the first and second buffer layers,
the first buffer layer having density that is lower than that of the second buffer layer,
the second part of the first buffer layer entirely extending along the side surface of the stepped portion, and
the sixth part of the second buffer layer entirely extending along the side surface of the fourth part of the first barrier layer.

US Pat. No. 10,793,951

APPARATUS TO IMPROVE SUBSTRATE TEMPERATURE UNIFORMITY

APPLIED MATERIALS, INC., ...

1. An apparatus to improve substrate temperature uniformity in a substrate processing chamber, comprising:a substrate processing chamber; and
a cover plate that covers a bottom portion of the substrate processing chamber, wherein the cover plate is coupled to and directly supported by a bottom portion of the substrate processing chamber, the cover plate comprising:
a disk body having a central opening, an outer lip, an upper surface extending to the outer lip, and a lower surface, wherein a plurality of purge gas openings are formed into the disk body along an outer edge of the outer lip that aligns with a purge gas exhaust located in the bottom portion of the substrate processing chamber;
an annular groove formed in the lower surface, wherein the annular groove aligns with and covers a pin lift hoop opening located in the bottom portion of the substrate processing chamber; and
a plurality of pin lift holes are formed through the disk body where the annular groove is located.

US Pat. No. 10,793,950

CVI/CVD PREFORM SEPARATOR

1. An article comprisinga CVI/CVD preform separator, including:
a body,
wherein the body includes
a plurality of thin sheets comprised of organic fibers,
a plurality of continuous layers including an adhesive, wherein each layer extends between two immediately adjacent sheets,
wherein the sheets and layers are carbonized after assembly,
the body after carbonization including
a pair of flat planar opposed side faces,
a periphery extending transversely between the opposed side faces,
a plurality of channels, wherein each of the channels extend from the periphery and through each of the pair of side faces,
wherein each of the channels is configured to enable carbon carrying gas flow therethrough from the periphery and out of the respective channel into a respective CVI/CVD preform in abutting relation with a respective side face.

US Pat. No. 10,793,949

SUBSTRATE PROCESSING APPARATUS AND SUBSTRATE PROCESSING METHOD USING THE SAME

EUGENE TECHNOLOGY CO., LT...

1. A substrate processing apparatus comprising:a pre-chamber into which a substrate is configured to be carried through a gate slit;
a process chamber communicating with the pre-chamber and in which a substrate processing process is performed;
a substrate boat comprising a plurality of partition plates having a circular plate shape to partition a loading space into which the substrate is configured to be loaded and a plurality of connection bars supporting the partition plates, and configured to elevate in the pre-chamber and the process chamber;
a gas supply unit comprising a plurality of injection nozzles and configured to supply a process gas to the substrate through the plurality of injection nozzles provided in the process chamber;
an exhaust unit comprising a plurality of suction holes and configured to exhaust a gas through the plurality of suction holes provided in the process chamber; and
a plurality of swap guide members respectively provided inside the pre-chamber in a direction that crosses a carrying direction of the substrate passing through the gate slit, and configured to support the substrate carried into the pre-chamber by an end-effector of a transfer module and then place the supported substrate on a substrate support tip formed in each of the plurality of partition plates or connection bars through lifting of the substrate boat,
wherein each of the plurality of swap guide members comprises:
a support part configured to support an edge of the substrate; and
a linear motor (LM) system connected to the support part and configured to move the support part horizontally in the direction crossing the carrying direction of the substrate, thereby adjusting a distance between the plurality of swap guide members,
wherein the plurality of connection bars are provided symmetrically with respect to the carrying direction of the substrate from the gate slit and include a first pair of connection bars provided symmetrically with respect to the carrying direction and a second pair of connection bars provided symmetrically with respect to the carrying direction, wherein the first pair of connection bars is closer to the gate slit than the second pair of connection bars and wherein a width between the connection bars in the first pair of connection bars is larger than a width between the connection bars in the second pair of connection bars and is also larger than a width of the substrate, and
wherein the support part has a fork at one side thereof on which the substrate is supported such that each of the connection bars in the first pair of connection bars is situated within the width of the corresponding fork when supporting the substrate on the support part, and comprises an aligning stepped part providing a side wall opposite a side surface of the substrate on an end of the fork.

US Pat. No. 10,793,948

FILM FORMING APPARATUS WITH COVER WHICH MINIMIZES DEBRIS IN THE CHAMBER

BOE TECHNOLOGY GROUP CO.,...

1. A film forming apparatus, comprising:a base having a first chamber;
an upper cover for at least covering an opening of the first chamber; and
a first seal ring between the upper cover and the base,
wherein the upper cover has an inclined slope, an orthographic projection of the inclined slope in a plane where a bottom surface of the base is located overlaps with a region surrounded by an orthographic projection of the first seal ring in the plane where the bottom surface of the base is located, the orthographic projection of the inclined slope in the plane where the bottom surface of the base is located is outside an orthogonal projection of the first chamber in the plane where the bottom surface of the base is located, and a portion of the inclined slope close to the first chamber is away from the bottom surface of the base with respect to a portion of the inclined slope away from the first chamber,
wherein the orthographic projection of the first seal ring in the plane where the bottom surface of the base is located is outside a region surrounded by the orthographic projection of the inclined slope in the place where the bottom surface of the base is located, the film forming apparatus further comprises: a second seal ring located between the upper cover and the base, and the orthographic projection of the inclined slope in the plane where the bottom surface of the base is located completely covers an orthogonal projection of the second seal ring in the plane where the bottom surface of the base is located, and
wherein an edge of the upper cover is provided with at least one first electromagnet, and an edge of the base is provided with a second electromagnet in one-to-one correspondence to the first electromagnet, wherein the first electromagnet and the second electromagnet are attracted mutually after being energized for connecting the upper cover and the base.

US Pat. No. 10,793,947

ALLOYS OF CO TO REDUCE STRESS

ENTEGRIS, INC., Billeric...

1. A vapor-deposited cobalt composition, comprising cobalt and one or more alloy component that is effective in combination with cobalt to enhance adhesion to a substrate when exposed on the substrate to variable temperature and/or delaminative force conditions, as compared to corresponding elemental cobalt, wherein the one or more alloy component comprises indium or boron at a concentration of from 0.025 to 0.15 at % based on atomic weight of the doped cobalt composition and wherein the cobalt is deposited from vapor of a cobalt precursor and the one or more alloy component is deposited from vapor of an alloy component precursor.

US Pat. No. 10,793,946

REACTION CHAMBER PASSIVATION AND SELECTIVE DEPOSITION OF METALLIC FILMS

ASM IP Holding B.V., Alm...

1. A process comprising passivating an interior surface of a reaction chamber prior to conducting a selective deposition process therein, wherein passivating comprises conducting a first vapor deposition process while the reaction chamber does not contain the substrate, wherein the first vapor deposition process comprises one or more deposition cycles in which the interior surface of the reaction chamber is contacted with a first vapor-phase precursor and a second vapor-phase precursor.

US Pat. No. 10,793,945

POWDER COATING APPARATUS

FURUYA METAL CO., LTD., ...

1. A powder coating apparatus comprising:a barrel;
exhaust means which evacuates an inside of the barrel; and
two or more sputtering devices installed inside the barrel,
the barrel having a main axis directed in a horizontal direction and rotating around the main axis, the two or more sputtering devices forming a coating film on a surface of powder put in the barrel,
wherein each of the two or more sputtering devices has one fixing portion for one target so that two or more targets are mountable in the powder coating apparatus,
respective targets are disposed along a length in parallel to each other and the length coincides with a direction of the main axis when the target is mounted on the fixing portion, and
when target surfaces of the respective target are projected normal to the respective target surfaces toward an inner side wall of the barrel, the respective targets are directed in a direction so that projections overlap each other before reaching the inner side wall.

US Pat. No. 10,793,944

PERPENDICULAR RECORDING MEDIA WITH ENHANCED ANISOTROPY THROUGH ENERGY ASSISTED SEGREGATION

Seagate Technology LLC, ...

1. A method comprising depositing on a substrate a perpendicular magnetic recording layer comprising respective amounts of a magnetic material comprising cobalt (Co), a non-magnetic material comprising Chromium (Cr), an oxide and an energy assisted segregation material comprising Boron (B) at an elevated, moderate energy level comprising a substrate temperature of from about 100° C. to about 150° C. and a substrate voltage magnitude of from above 0V to about 500V, wherein during said depositing of the magnetic recording layer a sputtering process is used while maintaining the substrate temperature and the substrate voltage magnitude such that the amount of the energy assisted segregation material relative to the amount of the magnetic material, the non-magnetic material and the oxide is adjusted to enhance segregation of the non-magnetic material into grain boundaries within the magnetic recording layer, and wherein said depositing of the magnetic recording layer comprises depositing a greater first amount of the energy assisted segregation material on the substrate at a beginning of the depositing of the magnetic recording layer to initiate formation of non-magnetic areas of the magnetic recording layer, and subsequently depositing a reduced second amount of the energy assisted segregation material on the substrate as the non-magnetic areas grow in size.

US Pat. No. 10,793,943

METHOD OF PRODUCING A GAS TURBINE ENGINE COMPONENT

Raytheon Technologies Cor...

1. A method of producing a gas turbine engine fan blade having a geometric configuration,the method comprising:
plastically deforming an initial substrate comprised of a first metallic material into a formed substrate that has a first face surface,
a second face surface,
the first face surface is opposite the second face surface, a first end surface and a second end surface,
the second end surface is opposite the first end surface; and depositing a second metallic material onto the formed substrate using an additive manufacturing process to produce a fan blade blank,
the depositing including:
depositing the second metallic material onto at least one of the first face surface or the second face surface of the formed substrate adjacent the first end surface,
to form a fan blade root portion;
depositing the second metallic material onto at least one of the first face surface or the second face surface of the formed substrate between the fan blade root portion and the second end surface to form a fan blade airfoil portion; and
shaping the fan blade blank into the geometric configuration of the gas turbine engine fan blade.

US Pat. No. 10,793,942

EQUIPMENT FOR PLASMA SPRAY WITH LIQUID INJECTION

Raytheon Technologies Cor...

1. A method of plasma spraying a multiple of workpieces comprising:rotating a turntable subsystem about a central axis, the turntable subsystem with a multiple of workpieces on a respective multiple of workpiece mounts, each of the multiple of workpiece mounts rotatable about a respective axis parallel to the central axis;
plasma spraying each of the multiple of workpieces with a plasma spray subsystem as the turntable subsystem rotates about the central axis;
locating a deflector along the central axis preventing plasma spray deposition on workpieces other than the one directly in front of the plasma spray subsystem; and
washing each of the multiple of workpieces sequentially with an overspray wash subsystem as the turntable subsystem rotates about the central axis, the overspray wash subsystem positioned around the turntable subsystem with respect to the plasma spray subsystem by about thirty to three hundred and thirty (30-330) degrees of said turntable subsystem rotation.

US Pat. No. 10,793,941

PLASMA SPRAYING SYSTEM WITH ADJUSTABLE COATING MEDIUM NOZZLE

Raytheon Technologies Cor...

1. A plasma spraying system for coating a substrate, the system comprising: a plasma gun adapted to direct a stream of a plasma along a first trajectory towards the substrate; a nozzle adapted to direct a coating medium into the stream of the plasma; and a mounting system adapted to rotate the nozzle to change an angle of incidence between the coating medium and the stream of the plasma; the mounting system including a curved track and a carriage mounted to the curved track; the curved track extending along a curved trajectory at least partially circumferentially around the first trajectory of the stream of the plasma such that the curved track is concentric with the plasma gun; and the carriage adapted to move the nozzle along the curved track, said mounting system including a telescoping joint adapted to move the nozzle along a first axis parallel with the first trajectory of the stream of the plasma; and a rotary joint adapted to rotate the nozzle about a second axis perpendicular to the first axis and the first trajectory of the stream of the plasma.

US Pat. No. 10,793,938

METHOD FOR PRODUCING BORON NITRIDE NANOTUBE-REINFORCED ALUMINUM COMPOSITE CASTING

HITACHI METALS, LTD., To...

1. A method for producing a boron nitride nanotube-reinforced aluminum composite casting, comprising the following steps of:(a) mixing boron nitride nanotubes and a first aluminum matrix and then pelletizing the resulting mixture;
(b) heating and subjecting pellets obtained in step (a) to melt mixing to obtain a melt;
(c) cooling and solidifying the melt obtained in step (b) to obtain a master batch; and
(d) subjecting the master batch obtained in step (c) and a second aluminum matrix to melt mixing, and then cooling and solidifying the resulting mixture.

US Pat. No. 10,793,935

CARBON-CONTAINING STEEL MATERIAL AND METHOD FOR PRODUCING SAME

CITIZEN WATCH CO., LTD., ...

1. A carbon-containing steel material, comprising: a base material made of steel containing carbon at 0.5% by weight to 1.0% by weight, an oxide layer of the steel on the base material having a thickness of 60 nm to 80 nm, which brings about deep interference film blue color, and a fluorine coating film on the oxide layer, wherein the oxide layer has 10 or fewer pinholes having a diameter of 0.3 ?m or more per a surface area having a dimension of 50 ?m ×50 ?m square.

US Pat. No. 10,793,934

COMPOSITION AND METHOD FOR ENHANCED PRECIPITATION HARDENED SUPERALLOYS

1. A superalloy composition consisting essentially of:1.5 to 4.5 wt % Al;
0.005 to 0.06 wt % B;
0.02 to 0.07 wt % C;
23.0 to 26.0 wt % Co;
11.8 to 16.0 wt % Cr;
18.6 to 19.0 wt % Ta;
0.005-0.10 wt % Zr; and
balance Ni and incidental impurities;
wherein the composition excludes Hf, Mo, Nb, Ti, and W in amounts greater than amounts occurring incidentally in the composition.

US Pat. No. 10,793,933

METHOD OF HEAT TREATMENT

ROLLS-ROYCE PLC, London ...

1. A method of heat treating a localised region of a component, the method comprising:providing a heat treatment assembly comprising two or more subassemblies, each subassembly configured to partially circumscribe a portion of the component for heat treatment, and each subassembly comprising a housing configured to partially circumscribe a portion of the component, an insulator and a heater provided within the housing and extending to partially circumscribe the component and arranged such that the insulator is between a wall of the housing and the heater, the housing including a hole configured to receive a thermocouple;
positioning the subassemblies adjacently around the component so that the subassemblies fully circumscribe the component;
connecting the subassemblies together;
positioning the thermocouple through the hole of the housing of one of the two or more subassemblies to contact the component; and
activating the heater to heat the component in a region adjacent the heater, wherein
the heater comprises a ceramic mat with a plurality of tiles, the tiles being arranged in rows, with the tiles of one row being offset from the tiles of an adjacent row.

US Pat. No. 10,793,931

STEEL SHEET, METHOD OF MANUFACTURING SAME, CROWN CAP, AND DRAWING AND REDRAWING (DRD) CAN

JFE STEEL CORPORATION, C...

1. A steel sheet comprising:a chemical composition containing, by mass %,
C: more than 0.006% and not more than 0.012%,
Si: 0.02% or less,
Mn: 0.10% or more and 0.60% or less,
P: 0.020% or less,
S: 0.020% or less,
Al: 0.01% or more and 0.07% or less, and
N: 0.0080% or more and 0.0200% or less,
with the balance being Fe and inevitable impurities; wherein
a dislocation density at a depth position of ½ of a sheet thickness from a surface of the steel sheet is 2.0×1014/m2 or more and 1.0×1015/m2 or less.

US Pat. No. 10,793,929

GRAIN-ORIENTED ELECTRICAL STEEL SHEET AND METHOD FOR MANUFACTURING SAME

POSCO, Pohang-si, Gyeong...

1. A grain-oriented electrical steel sheet, which has a surface which is formed with grooves for a magnetic domain refinement treatment,wherein a scattering alloy layer in the groove is eroded in a Goss texture during a recrystallization annealing process,
wherein when a thickness of the scattering alloy layer on a bottom surface of the groove is defined as TB, and a thickness of the scattering alloy layer at a point that is one-half the distance between any one end of the groove and the bottom surface of the groove is defined as TL, TB/TL is 0.2 to 0.8, and
wherein the groove is formed at an angle greater than 0° and equal to or smaller than 5° with respect to the width direction of the electrical steel sheet.

US Pat. No. 10,793,928

PLANT AND METHOD FOR THE THERMAL TREATMENT OF SOLIDS

OUTOTEC (FINLAND) OY, Es...

1. A method for the thermal treatment of iron containing oxide, in which fine-grained solids are heated in a preheating calcining stage and are exposed to a reduction gas in a subsequent reduction stage, wherein off-gas from the reduction stage is guided through a separation device, separating water originating from the reduction stage, wherein off-gas from the preheating calcining stage is guided through a venturi scrubber and a packed bed section downstream of the venturi scrubber to condense water vapor, wherein water separated in the separation device is recycled into a water treatment section, from which the recycled water is supplied to at least one of a water electrolysis plant or a steam reforming plant producing hydrogen, and that the produced hydrogen is supplied to at least one of the reduction stage as reductant, to the preheating calcining stage as fuel, to a gas heater as fuel, or from which the recycled water is supplied to the separation device as process water, wherein the process water exchanges heat with the off-gas, is cooled in the water treatment section and is recirculated to the separation device,wherein oxygen generated in the at least one of the water electrolysis plant or the steam reforming plant is supplied to at least one of the preheating calcining stage or the gas heater for the combustion of fuel.

US Pat. No. 10,793,927

SEPARATION OF LIGNIN AND SUGARS FROM BIOMASS PRE-TREATMENT LIQUORS

1. A process for separating lignin and monomeric sugars from a biomass pre-treatment liquor comprising lignin and monomeric sugars in a solvent mixture comprising water and an organic solvent, the process comprising:(a) subjecting the liquor to nanofiltration over a membrane capable of retaining lignin and permeating monomeric sugars; and
(b) subjecting a permeate originating from step (a) to selective water removal to obtain a suspension comprising precipitated monomeric sugars;
(c) precipitating lignin from a retentate originating from step (a), and
(d) isolating precipitated monomeric sugars from the suspension of step (b).

US Pat. No. 10,793,915

CONTEXT DEPENDENT DIAGNOSTICS TEST FOR GUIDING CANCER TREATMENT

Eutropics Pharmaceuticals...

1. A method for selecting a patient having acute myelogenous leukemia (AML) for treatment, comprising:a) permeabilizing an aliquot of cells obtained from a bone marrow aspirate of the patient, and permeabilizing an aliquot of cells from peripheral blood of the patient;
b) contacting the aliquot of permeabilized bone marrow aspirate cells with a NOXA peptide, wherein the NOXA peptide comprises the amino acid sequence of SEQ ID NO: 1, and contacting the aliquot of permeabilized peripheral blood with a BIM peptide;
c) measuring NOXA peptide-induced mitochondrial outer membrane permeabilization (MOMP) in the aliquot of bone marrow aspirate cells, and measuring BIM peptide-induced MOMP in the aliquot of permeabilized peripheral blood, to determine a percent priming for the NOXA peptide and the BIM peptide, as defined by the following equation:
wherein:the Peptide AUC comprises either an area under a curve or a signal intensity of the NOXA peptide, or the BIM peptide,
the CCCP (Carbonyl cyanide m-chlorophenyl hydrazone) AUC comprises either an area under a curve or a signal intensity of a baseline positive control, and
the DMSO AUC comprises either an area under a curve or a signal intensity of a baseline negative control,
d) comparing the percent priming of the NOXA peptide and the BIM peptide, and selecting the patient as suitable for therapy if the NOXA percent priming is greater than about 10% and the BIM percent priming is less than about 35%; and
e) administering a therapy comprising alvocidib to the selected patient of step (d).

US Pat. No. 10,793,904

METHODS FOR SEQUENCING A POLYNUCLEOTIDE TEMPLATE

Illumina Cambridge Limite...

1. A method for pairwise sequencing of a polynucleotide template, the method comprising:(a) providing a polynucleotide template immobilized on a surface, said polynucleotide template comprising
a first template strand having a first region, wherein the first template strand lacks a 5? phosphate group or comprises a blocked 5? phosphate group such that the first template strand is not capable of being ligated to a free 3? hydroxyl group, and
a first self-complementary hairpin polynucleotide linker comprising a loop region and a stem region, wherein the 5? end of one strand of the stem region is linked to the 3? end of said first template strand and the 3? end of the other strand of the stem region comprises a first free 3? hydroxyl group used for initiating sequencing of the first region of the first template strand,
(b) performing a first sequencing-by-synthesis reaction comprising sequential incorporation of different complementary reversibly-terminated nucleotides into the 3? end of said first self-complementary hairpin polynucleotide linker, thereby determining the sequence of the first region of the first template strand, wherein each of said nucleotides comprises a fluorescent label and a 3? blocking group, the blocking group prevents any further nucleotide incorporation into the 3? end of the polynucleotide template, and wherein said sequential incorporation comprise
(i) incorporating one of said nucleotides into the first free 3? hydroxyl group and detecting a fluorescent signal generated from the fluorescent label using a CCD camera or other fluorescence detection means, and
(ii) cleaving the fluorescent label and the 3? blocking group from said one of said nucleotides in the 3? end of said polynucleotide template, thereby yielding a free 3? hydroxyl group before another of said nucleotides is incorporated into the 3? end of said polynucleotide template,
(c) adding an unlabeled nucleotide to the free 3? hydroxyl group in the last nucleotide added in step (b) and performing an extension reaction in the presence of different unlabeled nucleotides, thereby generating a second template strand having a free 3? hydroxyl group, wherein the second template strand is complementary to the full length of said first template strand and comprises a second region,
(d) forming a ligation product by ligating a second self-complementary hairpin polynucleotide linker having a free 3? hydroxyl group to the free 3? hydroxyl group of the second template strand, whereby the free 3? hydroxyl group of the second self-complementary hairpin polynucleotide linker provides a second free 3? hydroxyl group used for initiating sequencing of the second region of the second template strand, and
(e) performing a second sequencing-by-synthesis reaction comprising sequential incorporation of different complementary reversibly-terminated nucleotides into the 3? end of the second self-complementary hairpin polynucleotide linker of said ligation product using a strand-displacing polymerase, thereby generating an extended complementary strand and determining the sequence of the second region of the second template strand, wherein each of said nucleotides comprises a fluorescent label and a 3? blocking group, the blocking group prevents any further nucleotide incorporation into the 3? end of said ligation product the extended complementary strand, and wherein said sequential incorporation after step (d) comprises
(i) incorporating one of said nucleotides into the second free 3? hydroxyl group and detecting a fluorescent signal generated from the fluorescent label using a CCD camera or other fluorescence detection means, and
(ii) cleaving the fluorescent label and the 3? blocking group from said one of said nucleotides in the 3? end of said ligation product,
thereby yielding a free 3? hydroxyl group before another of said nucleotides is incorporated into the 3? end of said ligation product;
wherein the first template strand ranges in length from 100 nucleotides to 1 kb.

US Pat. No. 10,793,902

REAL-TIME PCR POINT MUTATION ASSAYS FOR DETECTING HIV-1 RESISTANCE TO ANTIVIRAL DRUGS

The Government of the Uni...

1. A method for detecting the presence or absence of the 138K mutation in the integrase of HIV-1 subtype B, comprising:(a) contacting DNA with a mutation non-specific reverse primer and a mutation non-specific forward primer under conditions suitable for a polymerase chain reaction to produce amplified DNA; and
(b) contacting the amplified DNA of step (a) with a reverse primer and a mutation specific forward primer comprising SEQ ID NO: 133, under conditions suitable for a polymerase chain reaction; and
(c) detecting the presence or absence of the 138K mutation by detecting the presence or absence of an amplification product produced by the contacting of step (b).

US Pat. No. 10,793,901

REVERSIBLY PROTECTED NUCLEOTIDE REAGENTS WITH HIGH THERMAL STABILITY

Roche Molecular Systems, ...

1. A method of detecting the presence or absence of a target nucleic acid sequence in a sample comprising:a) performing an amplifying step comprising contacting the sample with amplification reagents to produce an amplification product if the target nucleic acid sequence is present in the sample, and
b) detecting the amplification product,
wherein the amplification reagents comprise a modified nucleoside polyphosphate having a structure of:

where B=purine or pyrimidine base or an analog, L=linker or nothing, Z=label or nothing, R=OH or O?, R1 and R2=H or OH, n=1-7, X=O, and Y is HO-CH2—CH2—S—S—CH2—CH2— and wherein Y can be removed chemically by a reducing agent.

US Pat. No. 10,793,891

NANOFLUIDIC DEVICE FOR ISOLATING, GROWING, AND CHARACTERIZING MICROBIAL CELLS

Northeastern University, ...

1. A method of isolating and culturing a microbial cell to obtain a monoculture of microbial cells, the method comprising the steps of:(a) exposing a fluid sample containing a mixture of microbial cells including said microbial cell to a device comprising a food chamber in fluid communication with an opening in the device, wherein the food chamber contains a culture medium containing a chemoattractant for said microbial cell and capable of supporting the growth and reproduction of said microbial cell, and wherein the opening allows only partial entry of said microbial cell;
(b) allowing said microbial cell to migrate into the opening of the device;
(c) maintaining the device under conditions suitable for allowing said microbial cell to divide while residing in the opening and produce progeny, whereby the progeny eventually enter the food chamber;
(d) maintaining the device under conditions suitable for the progeny entering the food chamber to multiply in the food chamber, forming a monoculture of microbial cells.

US Pat. No. 10,793,890

APPARATUS FOR DETECTING ATP IN A LIQUID SAMPLE

3M INNOVATIVE PROPERTIES ...

14. A method, comprising:using a sampling device to obtain a predetermined volume of a liquid sample;
wherein the sampling device comprises a sampling portion;
wherein the sampling portion is adapted to acquire and releasably retain a predetermined volume of liquid sample in one or more cavity, wherein the one or more cavity is not substantially defined by space between a plurality of fibers;
wherein the sampling device comprises a dry coating that includes an effective amount of a pH-adjusting reagent that, when contacted with a liquid reagent composition having a pH of about 6.8 or lower, changes the pH of the liquid reagent composition to 6.9 or higher;
wherein the liquid reagent composition comprises a luciferin;
contacting the predetermined volume of sample and the pH-adjusting reagent with a liquid reagent composition in a container to form a reaction mixture; and
using a luminometer to detect light emitted from the reaction mixture;
wherein the container comprises a cuvette portion adapted to be operationally coupled to the luminometer.

US Pat. No. 10,793,877

RECOMBINANT MEASLES VIRUSES EXPRESSING EPITOPES OF ANTIGENS OF RNA VIRUSES—USE FOR THE PREPARATION OF VACCINE COMPOSITIONS

INSTITUT PASTEUR, Paris ...

1. An immunogenic composition comprising (i) a recombinant measles virus expressing a heterologous amino acid sequence, or a recombinant measles virus expression vector, and (ii) an acceptable vehicle, wherein said virus or vector comprises a sequence comprising:A) a nucleotide sequence encoding the full length antigenomic (+)RNA strand of a measles virus vaccine strain;
B) a T7 promoter sequence comprising a GGG motif at its 3? end, operably linked to the nucleotide sequence of A;
C) a hammerhead ribozyme sequence located adjacent to the GGG motif at one end and adjacent to the first nucleotide of the nucleotide sequence encoding the full length anti-genomic (+)RNA strand of the measles virus strain at the other end;
D) a T7 terminator sequence operably linked to the nucleotide sequence of A;
E) the sequence of a hepatitis delta virus ribozyme located adjacent to the last nucleotide of the nucleotide sequence encoding the full length anti-genomic (+)RNA strand of the measles virus; and
F) a heterologous coding sequence encoding a heterologous amino acid sequence comprising an antigen of a heterologous RNA virus selected from a retrovirus and a flavivirus.

US Pat. No. 10,793,863

SYNTHESIS AND OXIDATION OF METHANE

AUBURN UNIVERSITY, Aubur...

1. A cell comprising a heterologous polynucleotide encoding a polypeptide having at least 70% sequence identity with a first Cfb polypeptide selected from Table 1; and comprising a second polynucleotide encoding a second polypeptide having at least 70% sequence identity with a second Cfb polypeptide selected from Table 1 wherein the second Cfb polypeptide is not the same as the first Cfb polypeptide.

US Pat. No. 10,793,862

COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION

Ionis Pharmaceuticals, In...

1. A method comprising administering to an animal a compound, or a composition comprising the compound and at least one of a pharmaceutically acceptable carrier and diluent, wherein the compound consists of a conjugate group and a modified oligonucleotide, wherein the nucleobase sequence of the modified oligonucleotide is the nucleobase sequence of SEQ ID NO: 703 and an anion form of the compound has the following chemical structure:

US Pat. No. 10,793,859

MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE

Janssen BioPharma, Inc., ...

1. A chimeric antisense oligonucleotide represented by Formula (A):5?X—Y—Z 3?  (A),
wherein
X—Y—Z is a chimeric oligonucleotide comprising a sequence of 18 to 22 nucleosides, optionally conjugated at the 5? and/or 3? end to a ligand targeting group;
X is a domain comprising a sequence of modified nucleosides that is 3-10 nucleosides in length;
Z is a domain comprising a sequence of modified nucleosides that is 3-10 nucleosides in length; and
Y is a domain comprising a sequence of 2 to 10 2?-deoxy-nucleosides linked through thiophosphate intersubunit linkages,
wherein each modified nucleoside in the X domain and each modified nucleoside in the Z domain are nucleosides of Formula (1)

wherein
R is H or a positively charged counter ion,
B is a nucleobase,
R1 is —(CR?2)2OCR?3 or -OEt, and
R? is independently in each instance H or F; and
wherein said oligonucleotide is complementary to a sequence of the HBV genome.

US Pat. No. 10,793,851

MULTIPLEXED BINARY ASSEMBLY AND QUANTITATIVE TRACKING OF BACTERIAL POPULATIONS

The Regents of the Univer...

1. A method for tracking combinations of mutations in one or more genetic sites of interest in cell populations comprising:a. transforming a population of cells comprising a heterologous nucleic acid sequence to form a population of cells comprising a unique nucleic acid barcode sequence;
b. assembling genetic sites of interest comprising genetic sites of interest having one or more mutation with the unique nucleic acid barcode sequences by multiplexed polymerase chain reaction (PCR) to form a binary assembly of genetic sites of interest comprising the genetic sites of interest having the one or more mutation linked to each unique nucleic acid barcode sequence; and
c. sequencing each binary assembly by paired end sequencing to determine which unique nucleic acid barcode sequences correspond to each genetic site of interest.

US Pat. No. 10,793,849

NUCLEIC ACID PURIFICATION CARTRIDGE

1. A microfluidic device comprising:one or more reservoirs upstream of a purification cavity;
one or more waste receiving containers downstream of the purification cavity;
the purification cavity defining an enclosed column with a tapered shape and hollow interior configured to be detachable from the microfluidic device, the purification cavity separate from and non-contiguous with any of the reservoirs or receiving containers, and comprising:
a first port configured to provide gas communication between the purification cavity and a vacuum generator, via a first flow path;
a second port configured to provide liquid communication between the purification cavity and the one or more reservoirs, via a second flow path; and
a third port configured to provide gas and liquid communication between the purification cavity and both the one or more waste receiving containers and the vacuum generator, via a third flow path; wherein the first, second, and third ports are positioned on an exterior peripheral surface of the purification cavity, and
a filter spanning a cross-section of the purification cavity orthogonal to the direction of liquid flow, configured to purify biological or chemical analytes from a complex biological sample and located adjacent to the third port such that fluid entering the purification cavity through the first or second port and exiting the bottom of the purification cavity through the third port flows through the filter.

US Pat. No. 10,793,848

IMMOBILIZED PROTEINS AND USE THEREOF

ENGINZYME AB, Solna (SE)...

1. An immobilized enzyme material comprising a carrier and at least one enzyme immobilized on the carrier, wherein the carrier comprises a carrier material to which an affinity matrix is attached, the carrier material being chosen from the group consisting of:(a) controlled porosity glass (CPG) having a pore size of 10 to 300 nm; and
(b) hybrid controlled porosity glass (Hybrid CPG) having a pore size of 10 to 300 nm;
and wherein:
the at least one enzyme contains an affinity tag and is immobilized on the carrier through specific affinity binding to the affinity matrix;
the affinity tag is a polyhistidine tag;
the affinity matrix contains a chelated metal ion; and
catalytic activity of the enzyme is maintained.

US Pat. No. 10,793,840

IDENTIFYING LIGANDS FOR BACTERIAL SENSORS

William Marsh Rice Univer...

1. A genetically engineered bacteria, comprising:a) a modified two-component sensor system (TCS), said TCS comprising:
i) a wild-type sensor histidine kinase (SK) comprising a sensing domain operably coupled to a kinase domain; and
ii) a modified response regulator (RR) that is cognate to said SK, said RR comprising a cognate receiver domain (REC) operably coupled to a non-cognate DNA binding domain (DBD) of known functionality; and
b) a reporter gene under the control of a promoter containing an operator site that is bound by said DBD, such that said reporter gene is activated or repressed when said SK signals to said modified RR and said DBD binds to said DNA binding site.

US Pat. No. 10,793,822

CONCENTRATING DEVICE AND METHOD FOR CONCENTRATING CELL SUSPENSION

NIPRO CORPORATION, (JP)

1. A concentrator comprising:a filtering device having a case provided with a filtration membrane in an internal space, an inflow port and a first outflow port bringing an inside of the filtration membrane and an outside of the case into communication with each other, and a second outflow port bringing an outside of the filtration membrane and an outside into communication with each other;
a liquid supply circuit connected to the inflow port;
a liquid discharge circuit connected to the first outflow port and the second outflow port;
a shaft that is rotatable and to which the filtering device is mechanically linked to rotate with the shaft so that positions in a vertical direction of the inflow port and the first outflow port change during rotation of the shaft;
a first rotation mechanism which actuates rotation of the shaft; and
a control portion configured to store a program, accept data input, and display output, the control portion configured to control operation of the first rotation mechanism so as to rotate the filtering device to a first orientation in which the inflow port is vertically higher than the first outlet port for a first operation of the filtering device including filtering cells of a cell suspension and a second orientation in which the inflow port is vertically lower than the first outlet port for a second operation of the filtering device.

US Pat. No. 10,793,821

TEST DEVICE

HITACHI HIGH-TECH CORPORA...

1. An testing instrument which performs an identification testing or an antimicrobial susceptibility testing of bacteria or fungi, the testing instrument comprising:a microplate having a plurality of wells, wherein the microplate holds in wells germs in a culture fluid containing antimicrobial agents and the bacteria or fungi;
an optical system that includes:
a light source,
a dichroic mirror that reflects light from the light source onto the microplate via an objective lens,
a filter located between the light source and the dichroic mirror, wherein the filter selectively permits all wavelengths of light from the light source to pass to the dichroic mirror when microscopic observations are performed and permits only light from the light source having a first wavelength to pass to the dichroic mirror when measurements of turbidity are performed,
a first photodiode that receives the light reflected by the dichroic mirror that has passed through the microplate,
a second photodiode that receives light that passes through the dichroic mirror without being reflected to the microplate, and
a CCD element that forms a microscopic image from light scattered by microplate via the objective lens;
a processor communicatively coupled to the optical system, wherein the processor is configured to:
obtain the microscopic image, by controlling the filter to permit all wavelengths of light from the light source to pass to the dichroic mirror and subsequently receiving the microscopic image from the CCD element,
calculate turbidity of the culture fluid held in each well of the microplate,
perform predetermined image processing on the microscopic image to form image data,
calculate an image processing result based on the image data,
generate influence determination information based the image processing result and the turbidity of the culture fluid held in each well of the microplate calculated, wherein the influence determination information indicates an influence of a target antimicrobial agent to the bacteria or fungi with respect to plural types of antimicrobial agents at one or more concentrations, and
display the influence determination information in a time series on a display screen, and
wherein the turbidity of the culture fluid held in each well of the microplate are calculated by:
controlling the filter to only pass the light from the light source having the first wavelength and
comparing an amount of light received by the first photodiode and the second photodiode.

US Pat. No. 10,793,820

MINIATURIZED, AUTOMATED IN-VITRO TISSUE BIOREACTOR

Lawrence Livermore Nation...

1. A system, comprising:a bioreactor coupled to a substrate, the bioreactor comprising:
a plurality of walls defining a reservoir;
a plurality of fluidic channels in at least some of the walls;
a fluidic inlet in fluidic communication with the reservoir via the fluidic channels;
a fluidic outlet in fluidic communication with the reservoir via the fluidic channels; and
a plurality of sensors coupled to the reservoir, at least some of the sensors each independently comprising a ring characterized by a diameter in a range from about 30 ?m to about 90 ?m, and each of the sensors being independently configured to monitor either or both of:
environmental conditions in the reservoir; and
physiological conditions of one or more cells when the one or more cells are present in the reservoir, wherein monitoring the physiological conditions of the one or more cells comprises: monitoring an individual morphology of some or all of the one or more cells, monitoring a population morphology of the one or more cells, monitoring an osmolarity of some or all of the one or more cells, monitoring an expression of one or more proteins by the one or more cells, and/or monitoring an expression of one or more nucleic acids by the one or more cells; and
a base plate coupled to the substrate, the base plate comprising:
a plurality of concentric depressions, at least one of the depressions being configured to engage the substrate, an outermost of the depressions being configured to engage a control board of the bioreactor, and an innermost of the depressions comprising a hole in the base plate;
a groove extending from the innermost of the depressions to the outermost of the depressions, the groove being configured to facilitate placing and/or removing components of the bioreactor into the base plate; and
a plurality of locking mechanisms configured to secure the bioreactor to the base plate; and
wherein the reservoir is arranged to receive at least media and the one or more cells directly from the fluidic channels.

US Pat. No. 10,793,818

CULTURE CONTAINER AND CELL CULTURING METHOD AND CELL OBSERVATION METHOD USING CULTURE CONTAINER

TOCALO CO., LTD., Kobe-S...

1. A culture container, comprising:a base having a concave portion formed therein;
a water repellent layer formed only on an outer edge region of a bottom surface of the concave portion and an inner circumferential surface of the concave portion;
and a central region having hydrophilicity and located inward of the outer edge region of the bottom surface of the concave portion,
wherein the outer edge region is formed in an annular shape along an outer peripheral line of the bottom surface of the concave portion,
wherein one surface of the water repellent layer is exposed to an internal space of the concave portion.

US Pat. No. 10,793,817

CELL CULTURE DEVICE

TOYODA GOSEI CO., LTD., ...

1. A cell culture device, comprising:a first inner cylinder formed in a tubular shape;
a cell culture membrane placed to cover over an entire first end of the first inner cylinder; and
an outer cylinder formed in a tubular shape, configured to place the first inner cylinder inside thereof such that a height direction of the outer cylinder is identical with a height direction of the first inner cylinder, and provided with a first slit overlapping with at least the first end of the first inner cylinder to be extended in the height direction, the first slit passing completely through the outer cylinder in a thickness direction of the outer cylinder, and the first slit being formed along the height direction in the entire outer cylinder.

US Pat. No. 10,793,816

TISSUE CULTURE CHIP

AUGUSTA UNIVERSITY RESEAR...

13. A bioreactor comprising a first and second media reservoir, wherein the first and second media reservoir comprise at least one opening on a cell culture surface of the reservoir, wherein the first and second reservoirs are positioned so that the cell culture surfaces containing the opening of each reservoir face each other and the opening of each reservoir aligns with the opening of the other reservoir; anda tissue culture cassette comprising a first and second gasket, wherein the first and second gaskets each comprise an opening that aligns when the first and second gaskets are combined, and
a cell culture matrix or scaffold sandwiched between the first and second gasket that covers the aligned openings of the gaskets to form an impermeable tissue culture cassette,
wherein the tissue culture cassette is positioned between the first and second media reservoirs so that the covered openings in the first and second gaskets align with the openings in the cell culture surfaces of the first and second media reservoirs to form an impermeable barrier between the first and second media reservoirs; and
a seal between the media reservoirs and the tissue culture cassette to prevent media leakage out of the openings in the cell culture surface of the media reservoirs.

US Pat. No. 10,793,815

METHOD OF PRODUCING A FINISHED, AGED DISTILLED SPIRIT

James Joseph Sanctified S...

1. A method of producing a finished, aged distilled spirit, comprising:placing an aged distilled spirit in a bottle;
placing a wood piece in the bottle, wherein the wood piece is used for in-bottle finishing of the aged distilled spirit and is rested in a spirit that differs from the aged distilled spirit before the placing of the wood piece; and
sealing the bottle, having located within the bottle both the aged distilled spirit and the wood piece.

US Pat. No. 10,793,814

FERMENTER

CASTLE COMMERCIAL ENTERPR...

1. A fermenter for fermenting a solution, comprising: a vat (2) predisposed for containing a solution (3) to be fermented, and provided with an inlet opening (4, 33) and an outlet opening (5, 25); a pumping-over conduit (100) provided with a first connection (101), which is placed in communication with a lower zone of the vat (2), and a dispensing opening (103), disposed in an upper zone of the vat (2) so as to be capable of delivering a liquid above the upper level of the solution (3); characterized in that the pumping-over conduit (100) comprises a second connection (102), disposed in an intermediate position between the first connection (101) and the dispensing opening (103), which dispensing opening (103) is so arranged as to allow a gas to be introduced into the pumping-over conduit (100), the fermenter further comprising accumulation means (7), which are structured so as to intercept and temporarily accumulate the gas (11) generated by fermentation, in which the second connection (102) of the pumping-over conduit (100) is in communication with the gas intercepted by the accumulation means (7).

US Pat. No. 10,793,813

DISPERSIBLE PACKAGING FOR TOILET PAPER MOISTENER PRODUCT

GPCP IP Holdings LLC, At...

9. A water dispersible pouch, the water dispersible pouch comprising:a polyvinyl alcohol film that encloses a cavity, the polyvinyl alcohol film having a body portion and a region of weakness, the region of weakness having a thickness that is less than a thickness of the body portion and a rupture strength of less than 10 pounds per square inch (psi); and
a substantially waterless wetting composition consisting of an oil and less than 15 weight % (wt. %) water disposed within the cavity.

US Pat. No. 10,793,812

CLEANING COMPOSITION AND METHOD FOR FABRICATING ELECTRONIC DEVICE USING THE SAME

SK hynix Inc., Icheon-si...

1. A method for fabricating an electronic device comprising a semiconductor memory, the method comprising:forming a material layer over a substrate;
forming a material pattern by etching the material layer, the etching providing an etch residue on sidewalls of the material pattern; and
removing the etch residue;
wherein the removing of the etch residue includes performing a cleaning process using a cleaning composition including water and a fluorine-containing compound or an amine and having a pH in a range of 7 to 14,
wherein the material pattern includes a variable resistance element including an MTJ (Magnetic Tunnel Junction) structure including a non-magnetic material layer, and wherein the cleaning composition is configured to remove a metal polymer or a metal oxide redeposited on sidewalls of the variable resistance element while preventing or minimizing damage to a non-magnetic material layer included in the MTJ structure.

US Pat. No. 10,793,811

LOW ALKALINE LOW TEMPERATURE WARE WASH DETERGENT FOR PROTEIN REMOVAL AND REDUCING SCALE BUILD-UP

Ecolab USA Inc., Saint P...

1. A low alkaline detergent use composition comprising:from about 1 ppm to about 250 ppm of an aminocarboxylate;
from about 1 ppm to about 250 ppm of a water conditioning polymer;
from about 1 ppm to about 250 ppm of a builder;
from about 5 ppm to about 1,000 ppm of a non-caustic alkalinity source; and
water,
wherein the use composition is free of surfactants and reduces or eliminates scale build-up and enhances protein removal on treated surfaces, and wherein the use composition has a pH between about 8 and about 9.5,
wherein the detergent use composition provides an effective sanitizing effect at wash temperatures that are not heated above about 140° F. when employed with a sanitizer, and
wherein the use composition contains sufficient use levels of the aminocarboxylate, water conditioning polymer, and builder to prevent the formation of precipitates in hard water sources.

US Pat. No. 10,793,810

STABLE LIQUID DETERGENT COMPOSITION CONTAINING A SELF-STRUCTURING SURFACTANT SYSTEM

1. A liquid detergent composition comprising:a) from 6% to 20%, by weight of the liquid detergent composition, of an anionic surfactant selected from the group consisting of C10-C14 linear alkyl benzene sulfonates (LAS), acid form thereof (HLAS), and mixtures thereof;
b) from 0.5% to 3%, by weight of the liquid detergent composition, of a zwitterionic surfactant that is cocamidopropyl betaine, lauramidopropyl betaine, or mixtures thereof;
c) wherein the composition is free of polyethylene glycol (PEG);
d) wherein the liquid detergent composition comprises a brightener; and
e) wherein the liquid detergent composition is free of alkoxylated alkyl sulfate (AES), wherein the liquid detergent composition comprises a mixture of lamellar and worm-like micelles.

US Pat. No. 10,793,809

ALKALINE CLEANING COMPOSITIONS COMPRISING A HYDROXYPHOSPHONO CARBOXYLIC ACID AND METHODS OF REDUCING METAL CORROSION

Ecolab USA Inc., Saint P...

1. A method for cleaning a hard surface comprising:contacting a hard surface with a cleaning composition comprising an alkalinity source and a hydroxyphosphono carboxylic acid; wherein the alkalinity source comprises an alkali metal hydroxide; wherein the hard surface is a food processing stainless steel clean-in-place surface, clean-out-of-place surface, or heat processing surface;
diluting the cleaning composition to form an aqueous cleaning solution; and wherein the aqueous cleaning solution has a pH of at least about 9; and
rinsing the hard surface.

US Pat. No. 10,793,804

AUTOMATIC TRANSMISSION OIL COMPOSITION

Hyundai Motor Company, S...

1. An automatic transmission oil composition, comprising:80 to 85 wt % of a base oil;
1 to 5 wt % of metallocene polyalphaolefin;
1 to 5 wt % of a detergent-dispersant;
0.01 to 0.03 wt % of a trinuclear molybdenum-based dialkyldithiocarbamate friction modifier;
3 to 10 wt % of a viscosity modifier; and
3 to 5 wt % of an antiwear additive,
wherein the trinuclear molybdenum-based dialkyldithiocarbamate friction modifier comprises a compound represented by Chemical Formula 2 below,

(In Chemical Formula 2, R1 to R4 are the same as or different from each other and are each independently as C1-C24 alkyl group, and X1 to X2 are the same as or different from each other and are each independently sulfur or oxygen).

US Pat. No. 10,793,801

LOW TRANSITION TEMPERATURE MIXTURES AND LUBRICATING OILS CONTAINING THE SAME

ExxonMobil Chemical Paten...

1. A composition comprising a eutectic mixture of:a first component comprising a quaternary amine having at most 6 carbon atoms per molecule; and
a second component comprising an ethylene glycol;
wherein a molar ratio of the first component to the second component in the mixture is in a range from 1:1 to 1:4, and the composition exhibits a glass transition temperature of no higher than ?70° C., a viscosity index of at least 120, and a kinematic viscosity at 100° C. in a range from 2.0 to 10 cSt.

US Pat. No. 10,793,799

PRELUBRICATED STOCK SHEET AND METHOD AND SYSTEM FOR MAKING THE SAME

Golden Aluminium Company,...

1. A method, comprising:heating a solid lubricant to form a liquid lubricant;
flowing the liquid lubricant to one or more pairs of applicators contained in an enclosure comprising a sheet inlet and a sheet outlet, wherein the enclosure is one or more of heated and insulated and wherein the enclosure is maintained at a temperature of from about 80 to 212 degrees Fahrenheit;
passing a stock sheet having opposing planar first and second stock sheet surfaces joined together by opposing stock sheet side edges and opposing stock sheet ends through the sheet inlet and the sheet outlet;
contacting the first and second stock sheet surfaces with the one or more pairs of applicators to form a lubricated stock sheet, wherein each of the one or more pairs of applicators deposits the liquid lubricant on the first and second stock sheet surfaces, and wherein no more than a total of from about 3 mg/foot2/side to about 200 mg/foot2/side of the liquid lubricant is deposited on the first and second stock sheet surfaces by the one or more pairs of applicators; and
winding the lubricated stock sheet into a coil.

US Pat. No. 10,793,798

PROCESS AND SYSTEM FOR PRODUCING ENGINEERED FUEL

WM INTELLECTUAL PROPERTY ...

1. A process for treating a solid waste material, the process comprising:removing a first set of waste components from the solid waste material, the first set of waste components comprising ferrous and non-ferrous metals;
shredding the solid waste material after the first set of waste components are removed from the solid waste material;
removing a second set of waste components from the solid waste material, the second set of waste components comprising one or more of organics, glass, aggregates, wood, electrical components, batteries, textiles, rubber and yard waste;
proportionally adding a clean stream to the solid waste material, the clean stream comprising fibers and clean plastics, such that a desired plastics content is introduced into the solid waste material;
removing a third set of waste components from the solid waste material, the third set of waste components comprising ferrous and non-ferrous metals;
reshredding the solid waste material;
densifying the solid waste material;
passing the solid waste through a screener to reject materials of 2-inch particle size or less after shredding the solid waste material to a particle size of 10-inch or less; and
prior to proportionally adding the clean stream to the solid waste material:
introducing the solid waste material into a separator, the solid waste material comprising heavier weight components, medium weight components and lighter weight components, wherein the combined medium weight components and lighter weight components have a combined density of 8 pounds/cubic foot or less,
separating the heavier weight components from the medium weight components and the lighter weight components in the separator,
positioning a receiver at either a first receiving location or a second receiving location with respect to the separator, wherein the receiver is capable of receiving the medium weight components and the light weight components, and wherein the first receiving location receives more of the medium weight components than the second receiving location, and
capturing an amount of the medium weight components and an amount of the lighter weight components in the receiver,wherein the solid waste material is shred to a particle size of 10-inch or less before removing the second set of waste components and is reshred to a particle size of 2-inch or less after removing the third set of waste components, and wherein the ferrous and non-ferrous metals of the first set of waste components have dimensions of 12-inch by 8-inch by ½-inch thickness or greater, and wherein the ferrous and non-ferrous metals in the third set of waste components have a size of ten square inches or smaller.

US Pat. No. 10,793,796

RENEWABLE DVPE ADJUSTMENT MATERIAL, FUEL BLEND CONTAINING THE SAME, AND METHOD FOR PRODUCING A FUEL BLEND

NESTE OYJ, Espoo (FI)

1. A light fuel composition comprising:fossil fuel,
ethanol, and
a material for adjusting a dry vapour pressure equivalent (DVPE adjustment material),
wherein the DVPE adjustment material is a bio-hydrocarbon composition,
wherein the bio-hydrocarbon composition has a content of naphthenes of from 30% by weight to 80% by weight,
wherein the bio-hydrocarbon composition has a content of paraffins of from 15% by weight to 70% by weight, wherein the majority of the paraffins in the bio-hydrocarbon composition contain 9 or 10 carbon atoms,
wherein the content of the ethanol in the light fuel composition is 40.0% by volume or less, and
wherein the majority of the bio-hydrocarbon composition contains 9 or 10 carbon atoms.

US Pat. No. 10,793,795

NANOCARBON PARTICLE BASED FUEL ADDITIVE

1. A combustion fuel additive for use in a fully formulated combustion fuel, the additive designed for improving the fully formulated combustion fuel's efficiency when the fuel combusts in an engine, the combustion fuel additive comprising:a) a base fuel for dispersion in the fully formulated combustion fuel;
b) colloidal nanodiamond particles, wherein the colloidal nanodiamond particles are dispersed in the base fuel; and
c) a surfactant dispersion stabilizer that aids in stably suspending the colloidal nanodiamond particles in the base fuel which surfactant dispersion stabilizer is dispersible in the fully formulated combustion fuel,where the colloidal nanodiamond particles comprise nanodiamonds modified by at least one modification selected from the group consisting of: a wet phase chemical reaction, gas phase chemical reaction, a chemical reaction induced photochemically, a chemical reaction induced electrochemically, a chemical reaction induced mechanochemically, annealing, modification by exposure to a plasma, modification by irradiation, modification by exposure to sonic energy and a modification during a process of nanodiamond synthesis by introducing dopants or defects.

US Pat. No. 10,793,793

INTEGRATED PYROLYSIS AND HYDROCRACKING UNITS FOR CRUDE OIL TO CHEMICALS

LUMMUS TECHNOLOGY LLC, B...

1. An integrated pyrolysis and hydrocracking process for converting a hydrocarbon mixture to produce olefins, the process comprising:mixing a whole crude and a gas oil to form a hydrocarbon mixture;
heating the hydrocarbon mixture in a heater to vaporize a portion of hydrocarbons in the hydrocarbon mixture and form a heated hydrocarbon mixture;
separating the heated hydrocarbon mixture, in a first separator, into a first vapor fraction and a first liquid fraction, wherein a vapor/liquid cut point of the separating in the first separator is in a range from 200° C. to 350° C.;
mixing steam with the first vapor fraction to form a steam-first vapor fraction mixture, superheating the steam-first vapor fraction mixture to form a superheated mixture, and feeding the superheated mixture to a first radiant coil in a radiant zone of a pyrolysis reactor to produce a thermally cracked effluent containing a mixture of olefins and paraffins;
feeding the first liquid fraction and hydrogen to a hydrocracking reactor system, contacting the first liquid fraction with a hydrocracking catalyst to crack a portion of hydrocarbons in the first liquid fraction, and recovering an effluent containing additional olefins and/or dienes from the hydrocracking reactor system;
separating unreacted hydrogen from hydrocarbons in the effluent;
fractionating the hydrocarbons in the effluent to form two or more hydrocarbon fractions, one of which is the gas oil.

US Pat. No. 10,793,792

SYSTEMS AND METHODS FOR THE CONVERSION OF HEAVY OILS TO PETROCHEMICAL PRODUCTS

Saudi Arabian Oil Company...

1. A method for processing a feedstock oil, the method comprising:hydrotreating the feedstock oil to reduce or remove one or more of sulfur content, metals content, nitrogen content, or aromatics content to produce a hydrotreated oil stream;
separating at least a portion of the hydrotreated oil stream into only a lesser boiling point oil fraction stream and a greater boiling point oil fraction stream in a flash drum;
hydrocracking the greater boiling point oil fraction stream; and
steam cracking the lesser boiling point oil fraction stream.

US Pat. No. 10,793,791

USE OF A BIFUNCTIONAL CATALYST BASED ON ZEOLITE IZM-2 FOR THE HYDROISOMERIZATION OF LIGHT PARAFFINIC FEEDSTOCKS RESULTING FROM FISCHER-TROPSCH SYNTHESIS

IFP Energies Nouvelles, ...

1. A process for producing middle distillates from a paraffinic feedstock produced by Fischer-Tropsch synthesis and divided into two fractions, a light fraction, known as cold condensate, and a heavy fraction, known as waxes, comprising at least the following steps:a) fractionation of said heavy fraction, known as waxes, so as to obtain a light fraction of the waxes, the final boiling point of which is between 350° C. and 400° C., and a heavy fraction of the waxes which boils above said light fraction,
b) mixing of said light fraction of the waxes, the final boiling point of which is between 350° C. and 400° C. derived from step a) with at least one portion of said cold condensate fraction,
c) hydrotreatment of the mixture derived from step b) in the presence of a hydrotreatment catalyst and which operates at a temperature of between 250 and 450° C., at a pressure of between 0.5 and 15 MPa, at a hydrogen flow rate adjusted in order to obtain a ratio of between 100 and 3000 standard litres per litre, and at an hourly space velocity of between 0.1 and 40 h?1,
d) hydroisomerization of at least one portion of the effluent derived from step c) in the presence of a catalyst comprising at least one noble metal from Group VIII of the Periodic Table and at least one zeolite IZM-2, step d) operating at a temperature of between 200 and 450° C., a pressure of between 1 and 15 MPa, a space velocity of between 0.1 and 10 h?1 and a hydrogen flow rate adjusted in order to obtain a ratio of between 100 and 2000 standard litres of hydrogen per litre of feedstock,
e) hydrocracking and hydroisomerization of at least one portion of the heavy fraction of the waxes derived from step a) in the presence of a hydrocracking catalyst and operating at a temperature of between 250° C. and 450° C., at a pressure of between 0.2 and 15 MPa, at a space velocity of between 0.1 h?1 and 10 h?1, and at a hydrogen flow rate adjusted in order to obtain a ratio of between 100 and 2000 standard litres of hydrogen per litre of feedstock, and
f) fractionation of the mixture of the effluent derived from step e) and the effluent derived from step d) so as to obtain at least one petrol fraction and at least one middle distillates fraction.

US Pat. No. 10,793,790

STORAGE OF FISCHER-TROPSCH EFFLUENTS

IFP Energies nouvelles, ...

1. A process for the production of middle distillates from a paraffinic feedstock produced by Fischer-Tropsch synthesis comprising at least the following stages:a) the said paraffinic feedstock resulting from a Fischer-Tropsch unit (A) is recovered, the said paraffinic feedstock comprising at least a light fraction (2), known as condensate, and a heavy fraction (3), known as waxes;
b) a least a part of the said light fraction and at least a part of the said heavy fraction which are obtained on conclusion of stage a) are sent, as a mixture (4), to a hydrotreating unit (D) in the presence of hydrogen and a hydrotreating catalyst to obtain a first hydrotreated effluent (5);
c) at least a part of the first hydrotreated effluent (5) obtained on conclusion of stage b) is sent to a hydrocracking/hydroisomerization unit (E) in the presence of hydrogen and of a hydrocracking/hydroisomerization catalyst to obtain a second effluent (6);
d) the second effluent (6) resulting from the hydrocracking/hydroisomerization unit is separated in a fractionation unit (F) to obtain at least a naphtha cut (7) having a maximum boiling point of less than 180° C., a middle distillates fraction (8,9) and an unconverted heavy fraction (10);
which process is characterized by periodic shutdowns of the hydrotreating unit and/or hydrocracking/hydroisomerization unit and when the hydrotreating unit (D) and/or the hydrocracking/hydroisomerization unit (E) is at shutdown, then:
the said light fraction (2) obtained on conclusion of stage a) is stored in a vessel (B) maintained under an inert atmosphere and in which the temperature inside the vessel is maintained at a value of less than 20° C.; and/or
the said heavy fraction (3) obtained on conclusion of stage a) is stored in a vessel (C) maintained under an inert atmosphere and in which the temperature inside the vessel is maintained at a value of between 80 and 230° C.

US Pat. No. 10,793,789

PROCESS AND APPARATUS FOR HYDROGENATION

NESTEC OYJ, Espoo (FI)

1. A process for hydrogenation of a hydrocarbon stream containing olefinic compounds, aromatic compounds or a combination thereof, the process comprising:i) feeding the hydrocarbon stream and hydrogen into a first reaction zone of a hydrogenation process unit;
ii) hydrogenating in the first reaction zone in a presence of a catalyst at least part of said aromatic compounds, olefinic compounds or a combination thereof to produce a first intermediate;
iii) cooling and separating said first intermediate into a first intermediate liquid stream and a first intermediate gas stream;
iv) conducting the first intermediate gas stream to a second reaction zone of the hydrogenation process unit;
v) conducting a portion of said first intermediate liquid stream to an inlet of the first reaction zone as a liquid recycle stream in order to restrict a temperature rise in the first reaction zone to less than 60° C., and conducting another portion of said first intermediate liquid stream to:
a) the second reaction zone, wherein remaining aromatic compounds, olefinic compounds or a combination thereof contained in said first intermediate liquid stream are hydrogenated with the first intermediate gas stream in a presence of a catalyst to produce a saturated product, or
b) a liquid bypass line, which bypasses the second reaction zone, wherein said first intermediate liquid stream contains a saturated product;
vi) separating the saturated product obtained from said second reaction zone or said liquid bypass line into a liquid product stream and a separated gas stream; and
vii) recovering the liquid product stream from the hydrogenation process unit,
wherein said steps from i) to vii) are conducted within a high-pressure section and are conducted at a constant set pressure selected from 2-8 MPa.

US Pat. No. 10,793,788

METHOD FOR TREATING A PYROLYSIS GASOLINE

IFP Energies Nouvelles, ...

1. A process for the treatment of a pyrolysis gasoline C5+ containing mono-olefin, diolefin and sulfur-comprising hydrocarbons, comprising at least and in any order:a) a stage where the pyrolysis gasoline or a C6+ hydrocarbon cut resulting from the pyrolysis gasoline is hydrotreated in the presence of hydrogen and at least one hydrotreating catalyst at a temperature of between 220 and 380° C., so as to produce a hydrotreated effluent;
b) a stage where the pyrolysis gasoline or the hydrotreated effluent resulting from stage a), when the latter is carried out before stage b), is separated in a separation column into a top C5? hydrocarbon cut and a bottom C6+ hydrocarbon cut, said separation column comprising a reboiling section including two heat exchangers, at least one of the two exchangers being configured in order to carry out a heat exchange with a part of the bottom cut which is recycled in the column via the reboiling section,
and in which one of the two heat exchangers of the reboiling section is fed with at least a part of the hydrotreated effluent, so to provide a part of the heat necessary for the operation of the reboiling section, and the other of the two heat exchangers is fed with a condensable fluid in the gas state that is pressurized steam.

US Pat. No. 10,793,787

PROCESS FOR THE PRODUCTION OF OLEFINS AND OF MIDDLE DISTILLATES FROM A HYDROCARBON EFFLUENT RESULTING FROM THE FISCHER-TROPSCH SYNTHESIS

IFP Energies Nouvelles, ...

1. Process for the production of olefins and of middle distillates from a paraffinic feedstock produced by Fischer-Tropsch synthesis comprising at least the following stages:a) the said paraffinic feedstock resulting from a Fischer-Tropsch unit (A) is recovered, the said paraffinic feedstock comprising at least a light fraction, known as condensate, and a heavy fraction, known as waxes;
b) at least a part of the said light fraction is sent to a catalytic cracking unit (C);
c) the effluent resulting from the catalytic cracking unit is separated in a fractionation unit (D) in order to obtain at least a fraction comprising light hydrocarbons, at least an olefinic fraction and at least a residual liquid fraction;
d) at least a part of the said heavy fraction is sent to a hydrocracking/hydroisomerization unit (F) in the presence of hydrogen and of a hydrocracking/hydroisomerization catalyst;
e) the effluent resulting from the hydrocracking/hydroisomerization unit is separated in a fractionation unit (G) in order to obtain a middle distillates fraction, a naphtha cut having a maximum boiling point of less than 180° C. and an unconverted heavy fraction;
f) at least a part of the said naphtha cut resulting from the fractionation unit is sent to the catalytic cracking unit.

US Pat. No. 10,793,786

BITUMEN PROCESSING AND TRANSPORT

Cenovus Energy Inc., Cal...

1. A converted bitumen comprising:asphaltene prills, the asphaltene prills comprising an asphaltene inner core comprising an asphaltene fraction that is more soluble in deasphalted oil and an asphaltene outer layer comprising an asphaltene fraction that is less soluble in deasphalted oil; and
deasphalted oil.

US Pat. No. 10,793,784

PROCEDURE FOR PREPARATION OF IMPROVED SOLID HYDROGEN TRANSFER AGENTS FOR PROCESSING HEAVY AND EXTRA-HEAVY CRUDE OILS AND RESIDUES, AND RESULTING PRODUCT

Instituto Mexicano del Pe...

1. A process for preparing improved solid hydrogen transfer agents for the processing of heavy or extra-heavy crudes or residues, comprising:a) preparing raw materials by grinding one of AlO (OH) (“Boehmite”), SiO2, Al2O3, and kaolin, or a mixture thereof, with an organic macromolecule featuring fused aromatic rings, said organic macromolecule having a melting or decomposition point above 450° C. when supported or extruded, while sieving the raw materials through a 165 mesh (0.089 mm), resulting in a physical mixture;
b) adding distilled water to the physical mixture and mixing until the mixed distilled water and physical mixture forms a paste, and subsequently peptizing the paste by adding an aqueous solution of nitric acid of 5% by volume to form a gel;
c) mixing the gel with a naphthalene polymer that may be supported on a metal oxide, resulting in a resin material with adequate properties for extruding;
d) extruding the resin by a mechanical extrusion system at a constant speed, and receiving the extrudates in metal trays;
e) drying the extrudates for a time period of about 12 hours to about 24 hours at room temperature, resulting in solid hydrogen transfer agents;
f) preparing the solid hydrogen transfer agents for activation by cutting the transfer agents to a length in a range of about 0.5 cm to about 1.2 cm and leaving the transfer agents in an oven at a temperature of about 90° C. to about 120° C. for a time period of about 12 hours to about 24 hours; and
g) loading the material obtained in part f) into a continuous flow reactor where a hydrogen flow of about 100 ml/min to about 150 ml/min, a pressure of about 40 kg/cm2 to about 70 kg/cm2, and a temperature between about 100° C. and about 500° C. is passed for a time of about 10 hours to about 24 hours.

US Pat. No. 10,793,783

WATER/CRUDE OIL REMOVERS BASED ON ALKYLACRYLIC-CARBOXYALKYLACRYLIC RANDOM COPOLYMERS OF CONTROLLED MOLECULAR MASS

Instituto Mexicano del Pe...

1. Random copolymers based on alkyl acrylate and carboxyalkyl acrylate as dehydrating agents, comprising:copolymers having the structural formula (2) with number average molecular weights between 900 and 472 500 g/mol:

wherein:
R1, R2, R3 and R4 are independent radicals represented by the groups mentioned below:
R1 and R3=H (hydrogen), CH3 (methyl);
R2=(methyl), C2H5 (ethyl), C4H9 (n-butyl, isobutyl), C6H13 (n-hexyl, iso-hexyl), C8H17 (2 ethyl-hexyl), C8H17 (n-octyl), C10H21 (n-decyl, iso-decyl), C12H25 (n-dodecyl), C18H37 (n-octadecyl), C8H9O (2-phenoxyethyl), C3H7O (2-methoxyethyl), C5H11O2 (2-(2-methoxyethoxy)ethyl), wherein the aliphatic chain may contain heteroatoms of the ether group, as well as aromatic rings or rings with heteroatoms of the ether group; and
R4=C3H5O2 (carboxyethyl), C4H7O2 (carboxypropyl) and C5H9O2 (carboxybutyl);
wherein, “x” is a number comprised in the range from 4 to 900 and “y” is a number comprised in the range from 4 to 900;
wherein “x” and “y” can be random sequences; and
wherein the copolymers are configured to remove emulsified water in crude oil with densities from 5 to 40° API.

US Pat. No. 10,793,781

METHOD FOR PRODUCING BIOHYDROCARBONS

NESTE OYJ, Espoo (FI)

1. A method for producing biohydrocarbons, the method comprising:providing an isomeric raw material obtained from a bio-renewable feedstock and containing at least 75 wt.-% iso-paraffins; and
thermally cracking the isomeric raw material to produce biohydrocarbons via a cracker,
wherein the thermal cracking is conducted at a coil outlet temperature (COT) of at most 825° C., the COT being a highest temperature in the cracker.

US Pat. No. 10,793,780

HEATING MATERIALS THROUGH CO-GENERATION OF HEAT AND ELECTRICITY

Red Leaf Resources, Inc.,...

1. A system for heating material through cogeneration of thermal and electrical energy, comprising:one or more bodies of material comprising crushed hydrocarbonaceous material contained within one or more impoundments;
a heat source and an electric generator oriented outside of the one or more bodies of material, where the heat source is configured to produce a hot exhaust gas and the electric generator produces electricity;
one or more heating conduits associated with the heat source, wherein the heating conduits are configured to carry the hot exhaust gas from the heat source to the one or more bodies of material; and
one or more electric heaters associated with the one or more heating conduits configured to reheat the hot exhaust gas after a portion of heat has been transferred from the hot exhaust gas to the one or more bodies of material, wherein the one or more electric heaters are at least partially powered by the electric generator.

US Pat. No. 10,793,779

METHOD FOR SEPARATING SOLUBLE ORGANIC MATTER IN PETROLEUM COKE

Shandong Chambroad Petroc...

1. A method for separating and detecting soluble organic matter in petroleum coke, comprising:drying the petroleum coke to obtain pretreated petroleum coke;
extracting the pretreated petroleum coke sequentially with petroleum ether, carbon disulfide, ethanol, acetone-carbon disulfide mixture and tetrahydrofuran to obtain an extract and treated petroleum coke, wherein the extract comprises soluble organic matter;
wherein the sequential extraction of the pretreated petroleum coke with petroleum ether, carbon disulfide, ethanol, acetone-carbon disulfide mixture and tetrahydrofuran specifically comprises:
mixing the pretreated petroleum coke and petroleum ether, carrying out a first-stage ultrasonic extraction for multiple times, and obtaining a first-stage extract and a first-stage residue; concentrating the first-stage extract to give a first-stage extract, and analyzing the first-stage extract;
mixing the first-stage residue and carbon disulfide, carrying out a second-stage ultrasonic extraction for multiple times, and obtaining a second-stage extract and a second-stage residue; concentrating the second-stage extract to give a second-stage extract, and analyzing the second-stage extract;
mixing the second-stage residue and ethanol, carrying out a third-stage ultrasonic extraction for multiple times, and obtaining a third-stage extract and a third-stage residue; concentrating the third-stage extract to give a third-stage extract, and analyzing the third-stage extract;
mixing the third-stage residue and acetone-carbon disulfide mixture, carrying out a fourth-stage ultrasonic extraction for multiple times, and obtaining a fourth-stage extract and a fourth-stage residue; concentrating the fourth-stage extract to give a fourth-stage extract, and analyzing the fourth-stage extract;
mixing the fourth stage residue and tetrahydrofuran, carrying out a fifth stage ultrasonic extraction for multiple times, and obtaining a fifth-stage extract and a fifth-stage residue; concentrating the fifth-stage extract to give a fifth-stage extract, and analyzing the fifth-stage extract;
wherein the temperature for each ultrasonic extraction is 30° C. to 40° C., and duration for each ultrasonic extraction is 1.5 h to 3 h.

US Pat. No. 10,793,778

COOLER FOR CARBON-BASED FEEDSTOCK PROCESSING SYSTEM

CLEAN ENERGY TECHNOLOGY A...

1. A cooler assembly for cooling product pursuant to a distillation process, the cooler assembly comprising:a first substantially enclosed housing with an inlet proximate a first end for receiving product from a distillation unit, and an outlet proximate a second end for discharging cooled product;
a first auger substantially enclosed within the housing for driving the product from the inlet to the outlet, the auger having a helical blade circumscribing a perforated central hollow shaft for transmitting cooled gas into the housing to help cool product within the housing; and
an exhaust port extending through and sealingly attached to the housing and configured to capture and to allow re-cooling of hot gases produced in the housing from cooling the product proximate the first auger, at a location outside the housing, wherein the exhaust port is additionally configured to recirculate re-cooled gases back to the perforated central hollow shaft.

US Pat. No. 10,793,776

COMPOSITIONS COMPRISING FUNCTIONALIZED POLYVINYL ALCOHOL AND NANOCAPSULES CONTAINING A LIQUID CRYSTALLINE MEDIUM

MERCK PATENT GMBH, Darms...

1. A method for preparing a composite, wherein the method comprises(i) providing nanocapsules which comprise a polymeric shell and a core containing a liquid crystalline medium, and
(ii) mixing the nanocapsules with a polymer comprising one or more of the repeating units A and/or B

and one or more of the repeating units C and/or D

wherein
Sp1 and Sp2 respectively represent a spacer group,
X11 represents CH2, CO, S—CO or NH—CO,
y is, independently in each occurrence, 0 or an integer from 1 to 10,
X12 represents, independently in each occurrence, 0, S, CO, NH or an ester group,
X13 represents, independently in each occurrence, 0, S, CO, NH or single bond, and
R11 is a polymerizable group.

US Pat. No. 10,793,775

ETCHING COMPOSITION AND METHOD FOR FABRICATING SEMICONDUCTOR DEVICE BY USING THE SAME

Samsung Electronics Co., ...

1. A method for fabricating a semiconductor device using an etching composition, comprising: forming a fin-type structure including a silicon pattern and a silicon-germanium pattern that are alternately stacked; forming a dummy gate electrode on the fin-type structure, the dummy gate electrode intersecting the fin-type structure; forming a first spacer on a sidewall of the dummy gate electrode; forming an interlayer insulating film that surrounds a sidewall of the first spacer and exposes an upper surface of the dummy gate electrode; forming a trench exposing the fin-type structure within the interlayer insulating film, by removing the dummy gate electrode; and forming a wire pattern using the etching composition, the wire pattern including the silicon pattern, the forming the wire pattern including removing the silicon-germanium pattern with wet etching from the fin-type structure exposed by the trench, the wet etching including using the etching composition, and wherein the etching composition includes a peracetic acid mixture, a fluorine compound, an acetate series organic solvent, water and at least one silicon compound, wherein the at least one silicon compound includes one of alkoxy silane compound, silanol compound, oxime silane compound, disilazane compound, or disiloxane compound, and wherein the at least one the silicon compound is included in a range of 0.01 wt % to 5 wt % with respect to a total weight of the etching composition.

US Pat. No. 10,793,773

COLOR STABLE RED-EMITTING PHOSPHORS

CURRENT LIGHTING SOLUTION...

1. A process for preparing a Mn+4 doped phosphor of formula I
the process comprising gradually adding a first solution comprising a source of M and HF and a second solution comprising a source of Mn to a reactor, in the presence of a source of A and an anion selected from phosphate, sulfate, acetate, and combinations thereof, to form a product liquor comprising the Mn+4 doped phosphor; and
gradually discharging the product liquor from the reactor while volume of the product liquor in the reactor remains approximately constant;
wherein
A is Li, Na, K, Rb, Cs, or a combination thereof;
M is Si, Ge, Sn, Ti, Zr, Al, Ga, In, Sc, Y, La, Nb, Ta, Bi, Gd, or a combination thereof;
x is the absolute value of the charge of the [MFy] ion; and
y is 5, 6 or 7.

US Pat. No. 10,793,772

MONOLITHIC PHOSPHOR COMPOSITE FOR SENSING SYSTEMS

ACCELOVANT TECHNOLOGIES C...

1. Monolithic ceramic metal oxide phosphor composite for measuring a parameter of an object comprising:a. a thermographic phosphor; and
b. a metal oxide material,
c. wherein the thermographic phosphor is mixed with the metal oxide material to form a metal oxide phosphor composite material which is subsequently dried and calcined to form a ceramic metal oxide phosphor composite, the composite is used for measuring a parameter of an object being measured.

US Pat. No. 10,793,770

ENHANCED PROPPANT TRANSPORT FOR HYDRAULIC FRACTURING

1. A method for enhancing proppant transport in fracturing fluids for hydraulic fracturing comprising the steps of:a) combining from 10-90% by weight of a dry naturally-derived polymer having a particle size below 500 ?m and from 10-90% by weight of dry synthetic friction reducer having a particle size below 500 ?m to form a dry friction reducing composition;
b) forming a liquid suspension from said dry friction reducing composition by adding said at least 20 percent by weight of said composition to a liquid carrier, the liquid carrier comprising mineral oil;
c) introducing said liquid suspension into a hydraulic fracturing fluid to form a treated hydraulic fracturing fluid;
d) adding said treated hydraulic fracturing fluid to a wellbore having a hole in a subterranean formation and
e) pumping said treated hydraulic fracturing fluid down said hole to frac said wellbore;wherein said treated hydraulic fracturing fluid carries a minimum of 3 ppa proppant, is more crosslinkable and has a higher breakability.

US Pat. No. 10,793,769

COMPOSITIONS INCLUDING ACIDIC CHELATOR FOR TREATMENT OF SUBTERRANEAN FORMATIONS INCLUDING ONE OR MORE FRACTURES

Halliburton Energy Servic...

1. A method of treating a subterranean formation, comprising:injecting a first pad fluid in the subterranean formation to form one or more primary fractures in the subterranean formation; then
injecting a second pad fluid in the subterranean formation to form secondary fractures in the subterranean formation branching out from the primary fractures, wherein the second pad fluid has a lower viscosity than the first pad fluid; then
repeating injecting the first and second pad fluids; and
injecting a composition into the subterranean formation, wherein the composition comprises an acidic chelator selected from the group consisting of: ethylenediaminetetracetic acid (EDTA), N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA), glutamic acid N,N-diacetic acid (GLDA), methyl-glycine-N,N-diacetic acid (MGDA), N-phosphonomethyl iminodiacetic acid (PMIDA), hydroxyiminodisuccinic acid (HIDS), (3-alanine diacetic acid, S,S-ethylenediaminedisuccinic acid, diethylenetriaminepentaacetic acid (DTPA), nitrilotriacetic acid (NTA), ethyleneglycoltetraacetic acid (EGTA), 1,2-bis(aminophenoxy) ethane-N,N,N?,N?-tetraacetic acid (BAPTA), cyclohexanediaminetetraacetic acid (CDTA), triethylenetetraaminehexaacetic acid (TTHA), N-hydroxyethylaminodiacetic acid, 2-hydroxyethyliminodiacetic acid, malic acid, tartaric acid, citric acid, a salt thereof, an ester thereof, or a combination thereof, wherein the composition is contained in the second pad fluid, or wherein the composition is contained in a third pad fluid injected after the repeated injection of the first and second pad fluids; and
enhancing a connectivity between the primary fractures and the secondary fractures with the composition.

US Pat. No. 10,793,767

STABILIZED FOAMS WITH TAILORED WATER CHEMISTRY FOR MOBILITY CONTROL IN GAS INJECTION PROCESSES

Saudi Arabian Oil Company...

1. A method of extracting a hydrocarbon product from a reservoir, comprising:combining an aqueous liquid and a gas vehicle, thereby producing a foam;
introducing the foam to the reservoir such that the hydrocarbon product in the reservoir is displaced; and
collecting the displaced hydrocarbon product, where:
the aqueous liquid comprises inorganic ions at a total concentration of 1 g/L to 9 g/L;
the aqueous liquid comprises one or more hydroxysultaine surfactants at a total concentration of 100 mg/L to 10 g/L;
the aqueous liquid comprises total dissolved solids at a concentration of 2 g/L to 20g/L; and
the density of the foam at atmospheric pressure is 100 g/L to 750 g/L.

US Pat. No. 10,793,762

LAYERED DOUBLE HYDROXIDES FOR OIL-BASED DRILLING FLUIDS

Saudi Arabian Oil Company...

1. An oil-based drilling fluid comprising:a base oil continuous phase comprising a base oil;
an aqueous dispersed phase; and
at least one rheology modifier comprising a magnesium/aluminum (Mg/Al) layered-double hydroxide (LDH) diamondoid compound.

US Pat. No. 10,793,760

MODIFICATION OF BENTONITE PROPERTIES FOR DRILLING FLUIDS

SAUDI ARABIAN OIL COMPANY...

1. A modified bentonite composition useful in drilling mud applications, the composition comprising:a powdery mixture composition comprising:
bentonite local to the Khulais area of Saudi Arabia, the bentonite having been ground to a fine powder, the ground fine powder between about 50 ?m and about 150 ?m in particle size,
a first polymer comprising polyanionic cellulose polymer with carboxymethylcellulose sodium salt, the first polymer present at about at least 3% by weight of the powdery mixture composition, the first polymer having a first viscosity in water, and
a second polymer comprising carboxymethylcellulose, the second polymer having a second viscosity in water, where the second viscosity is lesser than the first viscosity; and
water, where a ratio of yield point to plastic viscosity for the modified bentonite composition after static aging for at least 16 hours is between about at least 0.73 and about 1.10, with a pH between about 8.14 and about 8.93, the pH controlled in part by an amount of soda ash between about 1% by weight and about 2.5% by weight of the powdery mixture composition, and is sufficient for cuttings transport and suspension in the drilling mud applications, the modified bentonite composition not being modified by sodium hydroxide.

US Pat. No. 10,793,757

POLYMER COMPOSITIONS AND HOT-MELT ADHESIVES FORMED THEREFROM

Danimer Bioplastics, Inc....

1. A polymer composition comprising:a polymer comprising a lactic acid block and an aliphatic polyester block, the polymer having a structure of:

wherein G1 and G2 are independently (CHR)x, R is an alkyl group or H, and x is an integer ranging between 1 and 10;
wherein y is an integer ranging between 50 and 500;
wherein z is an integer ranging between 100 and 600;
wherein n is an integer ranging between 5 and 10,000;
wherein X is H, a functionalized alkylene polymer block containing alcohol functional groups, or a mixture thereof; and
wherein Y is H, an acyl group, a functionalized alkylene polymer containing carboxylic acid functional groups, or a mixture thereof.

US Pat. No. 10,793,750

METHODS FOR SEALING MICROCELL CONTAINERS WITH PHENETHYLAMINE MIXTURES

E Ink Corporation, Bille...

1. An electrophoretic display comprising a plurality of microcells having an opening that is sealed by the interaction of a first mixture and a second mixture, the first mixture comprising a phenethylamine or 3,4-dihydroxyphenylacetic acid and a first polymer, wherein the first polymer is a water swellable polymer, and the second mixture comprising a second polymer, wherein the plurality of microcells contain an electrophoretic material including a plurality of electrically charged particles disposed in a fluid and capable of moving through the fluid under the influence of an electric field.

US Pat. No. 10,793,747

HARD COATING COMPOSITION AND FLEXIBLE DISPLAY DEVICE INCLUDING THE HARD COATING COMPOSITION

SAMSUNG DISPLAY CO., LTD....

1. A display device comprising:a display panel; and
a window member positioned on at least one surface of the display panel, wherein the window member includes a coating layer, the coating layer including a cross-linked structure of a silsesquioxane compound that includes an epoxy group and an acryl group and having an indentation hardness of about 50 MPa or more and a tensile modulus of about 4.0 GPa or less,
wherein the coating layer includes a cross-linked structure formed from a curing reaction of a silsesquioxane compound including repeating units represented by Chemical Formulas 1, wherein an oxygen atom connected to * is connected to an adjacent Si atom in the siloxane oligomer, R1 represents an epoxy group or an alkyl group including an epoxy group, R2 represents a (meth)acryl group or an alkyl group including a (meth)acryl group, n and m independently represent a natural number, and a summation of n and m is from 6 to 100

US Pat. No. 10,793,746

COATING COMPOSITION COMPRISING SILICA-POLYMER CORE-SHELL PARTICLES, METHOD OF MAKING COMPOSITION AND ARTICLE

3M INNOVATIVE PROPERTIES ...

1. A composition comprising:an aqueous continuous liquid phase; and
composite particles dispersed in the aqueous continuous liquid phase, each composite particle comprising a non-cationic polymer core surrounded by a silica shell disposed on the polymer core, wherein the shell consists essentially of silica particles having a mean particle diameter of 3.2 nanometers or less, and wherein the polymer core comprises at least one polymer, wherein the weight ratio of the total amount of the silica in the composition to the total amount of the at least one polymer is in a range of 0.2 to 2.2, wherein the composition further comprises at least one metal cation having a charge of at least +2, and wherein the composition has a pH of 6 or less.

US Pat. No. 10,793,745

DUAL-CURE RESINS AND RELATED METHODS

Formlabs, Inc., Somervil...

1. A dual-cure resin for use in additive manufacturing, comprising:a photo-curable component configured to cure when subjected to an effective amount of actinic radiation; and
a secondary component comprising a first secondary precursor species isolated from a second secondary precursor species, the first secondary precursor species and the second secondary precursor species configured to react when subjected to an initiating event.

US Pat. No. 10,793,744

CARBOXY-FUNCTIONAL POLYETHER-BASED REACTION PRODUCTS AND AQUEOUS BASE COATS CONTAINING THE REACTION PRODUCTS

BASF COATINGS GMBH, Muen...

1. A pigmented aqueous basecoat material comprising a polyether-based reaction product which is prepared by a reaction of(a) trimesic acid
with
(b) at least one polyether of a general structural formula (I)

in which
R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 750 to 5000 g/mol,
the components (a) and (b) being used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possessing an acid number of 5 to 50 mg KOH/g.

US Pat. No. 10,793,743

COMPOSITION, METHODS AND DEVICES USEFUL FOR MANUFACTURING OF IMPLANTABLE ARTICLES

THE SECANT GROUP, LLC, T...

1. A method for printing a three-dimensional article comprising:extruding a first two-dimensional layer of a composition comprising water, an ester of a polyol and a diacid, and a polypeptide onto a substrate; and
building a second two-dimensional layer of the composition upon the first two-dimensional layer in a third dimension;
wherein the composition comprises a uniform aqueous dispersion of the ester and the polypeptide in the water.

US Pat. No. 10,793,741

ORGANIC-INORGANIC COMPOSITE PARTICLES, DISPERSION AND RESIN COMPOSITION COMPRISING THE SAME, AND METHOD FOR PRODUCING ORGANIC-INORGANIC COMPOSITE PARTICLES

TOHOKU UNIVERSITY, Senda...

1. A method for producing organic-inorganic composite particles comprising inorganic particles and an organic polymer, the method comprising:a first polymerization step of obtaining a hydrophilic block made of a first polymer by conducting a living radical polymerization of a first monomer in a reaction solution containing the inorganic particles, the first monomer, and a solvent, without conducting a modification treatment for introducing a polymerizable reactive group on surfaces of the inorganic particles, and allowing the first polymer thus obtained to be adsorbed on the surfaces of the inorganic particles; and
a second polymerization step of obtaining a hydrophobic block made of a second polymer by adding a second monomer to the reaction solution after the first polymerization step, conducting a living radical polymerization of the second monomer, and polymerizing the second polymer thus obtained onto growing ends of the first polymer, to stack the second polymer on an outside of the hydrophilic block,
wherein the inorganic particles, the first polymer, the second polymer, and the solvent have surface free energies satisfying a condition expressed by the following formula (2):
ENP>EA>EB>ES  (2)
where:
ENP represents the surface free energy of the inorganic particles,
EA represents the surface free energy of the first polymer,
EB represents the surface free energy of the second polymer, and
ES represents the surface free energy of the solvent.

US Pat. No. 10,793,732

INK COMPOSITION, INK SET, IMAGE RECORDING METHOD, AND METHOD FOR PRODUCING INK COMPOSITION

FUJIFILM CORPORATION, To...

1. An ink composition comprising:a microcapsule comprising: a shell having a three-dimensional cross-linked structure comprising at least one of a urethane bond or a urea bond; and a core encapsulated by the shell;
a colorant selected from the group consisting of a colorant having an ionic group and a colorant at least a part of a surface of which being covered with a dispersant having an ionic group; and
water,
a content ratio of an acidic group-containing compound having at least an acidic group, an acid dissociation constant of 5 or less, and a molecular weight of 2000 or less, relative to a total mass of the ink composition, is from 0.1 mass % to 0.5 mass %,
wherein the acidic group-containing compound is represented by Formula 1 below:

wherein, in Formula 1, R represents a hydrogen atom, an alkyl group, or an aryl group; Z represents an acidic group selected from the group consisting of a carboxy group, a sulfonic group, and a phosphate group; and L represents an alkylene group having 1 to 3 carbon atoms, an arylene group having 6 to 10 carbon atoms, or a divalent group that is a combination of an alkylene group having 1 to 3 carbon atoms and an arylene group having 6 to 10 carbon atoms.

US Pat. No. 10,793,730

SHORT-CHAIN FLUOROSURFACTANTS WITH IODIDE ADDITIVES FOR FORMING SILVER NANOWIRE-BASED TRANSPARENT CONDUCTIVE FILMS

Cambrios Film Solutions C...

1. A method comprising:providing a coating composition on a substrate, the coating composition comprising:
from 0.05% to 1.4% by weight of conductive nanostructures;
from 0.02% to 4% by weight of a viscosity modifier;
from 94.5% to 99.0% by weight of a liquid carrier; and
from 0.0025% to 0.1% by weight of a purified surfactant formulation comprising:
(1) a short-chain fluorosurfactant represented by Formula (I):

(2) an impurity represented by Formula (II) at an amount of less than about 3% by weight of the short-chain fluorosurfactant,
and(3) an iodide additive providing iodide at an amount of about 0.5-2.5% by weight of the short-chain fluorosurfactant, wherein:
m is 0, 1, 2, 3, 4, 5, or 6;
n is 1, 2, 3, or 4;
X is —O—,—S—, or a direct bond;
Y is hydrogen,—OH, or fluoro;
Z is —CH3,—CH2F,—CHF2, or —CF3;
M+is Li+, Na+, K+, H+, or NH4; and
R1, R2, R3, R4 and R5, at each occurrence, are the same or different and independently fluoro or hydrogen; and
drying the coating composition to form a conductive network layer.

US Pat. No. 10,793,720

RECLAIMED ASPHALT COMPOSITION AND METHODS OF MAKING AND USING SAME

Kraton Polymers U.S. LLC,...

1. A method of forming a paving composition comprising:providing a rejuvenated asphalt binder consisting essentially of bitumen, a block copolymer composition and a bio-oil, wherein the rejuvenated asphalt binder has a rotational viscosity at 135° C. of equal to or less than 1000 centipoise, an original G*/sin ? at 64° C. of equal to or greater than 1 kPa where G* is the complex shear modulus and ? is the phase angle; and after aging in a Rolling Thin Film Oven (RTFO) a G*/sin ? at 64° C. of equal to or greater than 2.2 kPa and % recovery at 3.2 kPa of equal to or greater than 80%;
providing a virgin asphalt;
heating the virgin asphalt to a temperature from 160° C. to 200° C.;
providing a reclaimed asphalt pavement (RAP) and/or a reclaimed asphalt shingle (RAS);
mixing the heated virgin asphalt, RAP, and the rejuvenated asphalt binder under conditions suitable for the formation of the paving composition.

US Pat. No. 10,793,718

RESIN COMPOSITION, AND SHEET, LAMINATE, POWER SEMICONDUCTOR DEVICE, AND PLASMA PROCESSING APPARATUS INCLUDING THE SAME, AND METHOD OF PRODUCING SEMICONDUCTOR USING THE SAME

Toray Industries, Inc., ...

1. A resin composition comprising:(A) a polyimide resin containing 60 mol % or more of a diamine residue having a structure represented by General Formula (1) below in all diamine residues;
(B) a thermosetting resin; and
(C) a thermally conductive filler,
Wherein
the resin composition contains 0.1 to 15 parts by weight of the thermosetting resin (B) relative to 100 parts by weight of the polyimide resin (A),
the resin composition contains 60 parts by volume or more of the thermally conductive filler (C) in 100 parts by volume of a total of the polyimide resin (A), the thermosetting resin (B), and the thermally conductive filler (C):

wherein R1 to R4 may each be same or different and represent an alkyl group having 1 to 30 carbon atoms, a phenyl group, or a phenoxy group, and the phenyl group and the phenoxy group may be substituted with an alkyl group having 1 to 30 carbon atoms; R1s and R3s may each be same or different; R5 and R6 may each be same or different and represent an alkylene group having 1 to 30 carbon atoms or an arylene group, and the arylene group may be substituted with an alkyl group having 1 to 30 carbon atoms; and m represents a range of 10 or more.

US Pat. No. 10,793,716

RESIN COMPOSITION AND USES OF THE SAME

TAIWAN UNION TECHNOLOGY C...

1. A resin composition, comprising:(a) a resin of formula (I):

(b) a nonpolar vinyl-containing elastomer selected from the group consisting of polybutadiene, polyisoprene, styrene-containing polymers, and combinations thereof, wherein the content of the vinyl group contained in the elastomer is no more than 60%;
(c) a peroxide as a polymerization initiator;
a cross-linking agent selected from the group consisting of bismaleimide (BMI) resins, triallyl isocyanurate (TAIC), and a combination thereof, wherein the amount of the cross-linking agent is 10% to 200% based on the weight of component (a); and
a solvent which can dissolve or disperse the components of the resin composition but does not react with the components of the resin composition,
wherein,
R1 and R2 are independently H or a substituted or unsubstituted methyl group;
A1 and A2 are independently

 wherein R3 is —O— or —SO2—;
n is an integer ranging from 10 to 40;
the amount of component (b) is 2% to 50% based on the weight of component (a);
the amount of component (c) is 0.01% to 4% based on the total weight of component (a) and component (b); and
the resin composition does not include a polar vinyl-containing elastomer.

US Pat. No. 10,793,711

EPOXY RESIN COMPOSITION FOR SEALING SEMICONDUCTOR DEVICE, AND SEMICONDUCTOR DEVICE SEALED USING SAME

SAMSUNG SDI CO., LTD., Y...

1. An epoxy resin composition for encapsulation of semiconductor devices, comprising: an epoxy resin; a curing agent; an inorganic filler; and at least one additive selected from the group consisting of a curing accelerator, a coupling agent, a release agent and a colorant, the epoxy resin composition having a gel content of about 1 ppm or less.

US Pat. No. 10,793,710

THERMOPLASTIC RESIN COMPOSITION AND MOLDED PRODUCT COMPRISING SAME

Lotte Advanced Materials ...

1. A thermoplastic resin composition comprising:a first aromatic vinyl-based resin comprising a copolymer formed of monomers consisting of an aromatic vinyl-based monomer and maleic anhydride;
a second aromatic vinyl-based resin comprising a copolymer of an aromatic vinyl-based monomer, maleic anhydride and a maleimide-based monomer represented by Formula 1;
a rubber-modified vinyl-based graft copolymer; and
reinforcing fillers,

where R1 is a C1 to C20 hydrocarbon group.

US Pat. No. 10,793,709

POLYMER MIXTURE, MULTILAYER ARTICLE CONTAINING THE SAME, AND PROCESS OF PREPARING THE MULTILAYER ARTICLE

Dow Global Technologies L...

1. A synthetic sports surface comprising a polymer mixture, wherein the polymer mixture comprises an aqueous binder composition and vulcanized or crosslinked rubber, wherein the aqueous binder composition comprises:(a) a first acrylic emulsion (co)polymer having a glass transition temperature of ?45° C. to ?5° C.,
(b) a second acrylic emulsion (co)polymer having a glass transition temperature of at least 15° C., and
(c) a crosslinking agent comprising a water-dispersible isocyanate composition;
wherein the crosslinking agent further comprises an epoxy silane, said epoxy silane being a functional silane having at least one epoxy group and said epoxy silane having the structure of Formula (V):
wherein R2 is an alkyl group having one to 6 carbon atoms; R3 is a bivalent organic group having a molecular weight of 200 or less; R4 is a hydrogen atom or an alkyl, aryl, or aralkyl group having one to 20 carbon atoms; and m is one, 2 or 3; andwherein the vulcanized or crosslinked rubber has a sieve particle size of from 0.1 to 6 mm, and the weight ratio of total acrylic emulsion (co)polymers to the vulcanized or crosslinked rubber is from 1:12 to 1:1;
wherein the synthetic sports surfaces has an elongation at break of at least 40%, according to the GB/T 14833-2011 standard.

US Pat. No. 10,793,707

COMPOSITION WITH BALANCE OF DISSIPATION FACTOR AND ADDITIVE ACCEPTANCE

Dow Global Technologies L...

1. A composition comprising:a) an ethylene-based copolymer comprising:
(i) units derived from ethylene and units derived from at least one comonomer of Structure I,

wherein R is a C1-C2 hydrocarbyl group and R? is a C1-C4 hydrocarbyl group; and
(ii) a comonomer content from greater than 0 to 0.30 mol/100 g;
b) at least one antioxidant,
c) from greater than 0 wt% to less than 3 wt% of an organic peroxide, based on the total weight of the composition, d) optionally, at least one co-agent, and e) optionally, at least one tree retardant, wherein the ethylene-based copolymer has a melt temperature (Tm) (° C.) and a comonomer content in moles per 100 grams ethylene-based copolymer (mol/100 g) (comonomer) that satisfies the relationship Tm the composition having a dissipation factor from 0% to 0.001%, at a temperature of 105° C. and an electrical stress of 12 kV/mm.

US Pat. No. 10,793,702

METHOD FOR MANUFACTURING MASTERBATCH, METHOD FOR MANUFACTURING TIRE RUBBER COMPOSITION, AND METHOD FOR MANUFACTURING TIRE

TOYO TIRE CORPORATION, I...

1. A masterbatch manufacturing method comprising an operation in which rubber latex and a carbon black slurry comprising a compound according to Formula (I) are mixed;wherein Formula (I) is given by
andwherein, at Formula (I), R1 and R2 each indicates a hydrogen atom, an alkyl group having 1 to 20 carbons, an alkenyl group having 1 to 20 carbons, or an alkynyl group having 1 to 20 carbons;
R1 and R2 may be the same or different; and
M+ indicates sodium ion, potassium ion, or lithium ion.

US Pat. No. 10,793,686

PREPARATION METHOD OF VINYL ESTER RESIN FOR OPTIMIZING HEAT-RELEASE DURING CURING

National Chung-Shan Insti...

1. A preparation method of vinyl ester resin for optimizing heat-release during curing, comprising:(A) providing a vinyl ester, a solvent and a phase change material to perform mixture; and
(B) performing a heating process to remove the solvent, so as to obtain a vinyl ester resin containing the phase change material.

US Pat. No. 10,793,684

METHOD OF REDUCING AN ORGANIC POLLUTANT IN CONTAMINATED WATER

King Abdulaziz University...

1. A method of reducing an organic pollutant in contaminated water, comprising:crosslinking an acidic aqueous solution of chitosan with formaldehyde to form a crosslinked chitosan hydrogel;
neutralizing the crosslinked chitosan hydrogel;
soaking the crosslinked chitosan hydrogel in a loading solution comprising water and a transition metal salt to form a metal ion-loaded crosslinked chitosan hydrogel;
drying and milling the metal ion-loaded crosslinked chitosan hydrogel to form a metal ion-loaded crosslinked chitosan microgel;
mixing the metal ion-loaded crosslinked chitosan microgel with a reduction solution comprising water and a first reducing agent to reduce the transition metal salt to metal nanoparticles and form a metal nanoparticle-loaded crosslinked chitosan microgel, wherein the transition metal salt is a silver salt and the transition metal nanoparticles are present in an amount of 5 to 60 wt % based on a total weight of the metal nanoparticle-loaded crosslinked chitosan microgel; then
contacting the contaminated water with the metal nanoparticle-loaded crosslinked chitosan microgel in the presence of a second reducing agent to react with the organic pollutant and form a purified water having less of the organic pollutant.

US Pat. No. 10,793,683

BLOCK CO-POLY(METAL ORGANIC NANOSTRUCTURES) (BCPMONS) AND USES THEREOF

Massachusetts Institute o...

1. A (block co-polymer)-(metal organic nanostructure) conjugate (BCPMON) comprising:(i) y instances of a transition metal ion, wherein y is an integer between 1 and 1,000, inclusive;
(ii) z instances of a ligand of Formula (C):

wherein:
z is an integer between 2 and 200, inclusive;
s is an integer between 2 and 10, inclusive;
each instance of RD is hydrogen;
each instance of T is independently —O—(CH2)t—O—, wherein t is an integer between 4 and 16, inclusive;
each instance of W is substituted or unsubstituted, C2-200 heteroalkylene, wherein one carbon atom or one heteroatom, of the substituted or unsubstituted, C2-200 heteroalkylene, is replaced with

wherein —(R)p-(G)q-(R)u-(G)v-E is closer to the attachment point labeled with “***” than the attachment point labeled with “**”;
each instance of R is independently a diradical of a first polymer, wherein:
the glass transition temperature (Tg) of each instance of the first polymer is not higher than 20° C.; and
the number-average molecular weight (Mn) of the first polymer is between 1,000 g/mol and 1,000,000 g/mol, inclusive;
each instance of G is independently a diradical of a second polymer, wherein:
the Tg of each instance of the second polymer is higher than 20° C.; and
the Mn of the second polymer is between 300 g/mol and 100,000 g/mol, inclusive;
each instance of p is independently 0 or 1;
each instance of q is independently 0 or 1, provided that at least one instance of p and q is 1;
each instance of u is 0;
each instance of v is 0; and
each instance of E is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —ORa, —N(Ra)2, —SRa, —CN, —SCN, —C(?NRa)Ra, —C(?NRa)ORa, —C(?NRa)N(Ra)2, —C(?O)Ra, —C(?O)ORa, —C(?O)N(Ra)2, —NO2, —NRaC(?O)Ra, —NRaC(?O)ORa, —NRaC(?O)N(Ra)2, —OC(?O)Ra, —OC(?O)ORa, or —OC(?O)N(Ra)2; and
unless otherwise provided, each instance of Ra is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of Ra are joined to form a substituted or unsubstituted heterocyclic or substituted or unsubstituted heteroaryl ring;
wherein each instance of the transition metal ion and at least one instance of the ligand of Formula (C) form through one or more coordination bonds a coordination complex; and
wherein each of the coordination bonds is formed between an instance of the transition metal ion and an instance of the oxygen atom labeled with “*”; and
(iii) at least one instance of an anionic counterion;
wherein the BCPMON is electrically neutral.

US Pat. No. 10,793,681

HYDROSILYLATION CURABLE SILICONE RESIN

Dow Silicones Corporation...

1. A hydrosilylation curable polysiloxane comprising at least one of units of formula (I) and units of formula (II)
wherein Ar is C6-C20 aryl, R1 is C2-C8 alkenyl, and R2, R3, R4 and R5 independently are C1-C4 alkyl; and wherein the polysiloxane comprises unit of formula (I) and in which less than 25 mole % of R1 groups in the hydrosilylation curable polysiloxane is from units of formula (II), an [R2R3SiO2/2] unit in formula (I) or formula (II) is part of a polysiloxane chain having from 10 to 500 [R2R3SiO2/2] units, the polysiloxane comprises from 20 to 60 mole % [ArSiO3/2] units and from 40 to 80 mole % [R2R3SiO2/2] units, and the polysiloxane further comprises from 0.5 to 4.5 mole % [R1SiO3/2] units.

US Pat. No. 10,793,679

RADICALLY CURABLE ORGANOSILOXANE GRAFT POLYVINYL ALCOHOL POLYMER AND PROCESS FOR PRODUCING SAME

SHIN-ETSU CHEMICAL CO., L...

1. A radically curable organosiloxane graft polyvinyl alcohol polymer which comprises structural units represented by both of the following general formula (1) and general formula (2),
wherein, M1 represents a siloxane group represented by the following general formula (3) and/or general formula (4); and M2 represents an organic group having an unsaturated group represented by the following general formula (5),

wherein, R1, R2, R3, and R4 each represent a monovalent organic group having 1 to 6 carbon atoms; “n” represents an integer of 1 to 10; and “a” represents an integer of 0 to 2,

wherein, R5, R6, R7, R8, and R9 each represent a monovalent organic group having 1 to 6 carbon atoms; “n” represents an integer of 1 to 10; and “m” represents an integer of 1 to 20,

wherein, R10 represents hydrogen or a methyl group; and “k” represents 1 or 2.

US Pat. No. 10,793,678

FILLERS FOR POLYMERS

AGENCY FOR SCIENCE TECHNO...

1. A composite material comprising a core and an amine functionalized elastomeric polymer bonded onto the core, wherein the core comprises octahedral oligomeric silsesquioxane, and wherein the elastomeric polymer is poly(n-butylacrylate), andwherein the composite material is obtained by:
providing a core comprising octa(3-hydroxy-3-methylbutyldimethylsiloxy)-POSS;
activating the core by converting the hydroxyl group of octa(3-hydroxy-3-methylbutyldimethylsiloxy)-POSS to a bromo group;
contacting the activated core comprising octabromopropionyl polyoctahedral silsesquioxane with an elastomeric polymer of poly(n-butylacrylate), and
functionalizing the elastomeric polymer with a reactive functional group.

US Pat. No. 10,793,677

POLYMER AND RESIN COMPOSITION CONTAINING THE SAME

NISSAN CHEMICAL INDUSTRIE...

1. A resin composition, comprising:a polymer having a structural unit of Formula (1):

wherein A1 and A2 are each independently an —O— group or a —C(?O)O— group; X is a divalent organic group having at least one aromatic ring or heterocyclic ring, wherein, when the X has two or more aromatic rings or heterocyclic rings, the rings are optionally bonded to each other via a single bond, are optionally bonded to each other via a heteroatom, or optionally form a condensed ring; and Y is a divalent organic represented by Formula (g)

a cross-linking agent; and
a solvent.

US Pat. No. 10,793,676

POLYIMIDES

Fujifilm Electronic Mater...

1. A polyimide polymer containing the reaction product of components (a), (b), and optionally (c), wherein components (a), (b), and (c) are:(a) at least one diamine of Structure (I):

(b) at least one tetracarboxylic acid dianhydride, and optionally;
(c) at least one compound containing a first functional group reactive with an amine or an anhydride and at least one second functional group selected from the group consisting of an unsubstituted alkenyl group and an unsubstituted alkynyl group, wherein the first functional group reactive to an amine is selected from the group consisting of an anhydride group, an acid halide group, an epoxy group, and an isocyanate group and the first functional group reactive to an anhydride is selected from the group consisting of an amino group, a hydroxyl group, and a thiol group,
wherein each of R6, R7, R8, R9, and R10, independently, is H, an unsubstituted C1-C6 linear or branched alkyl group, or an unsubstituted C5-C8 cycloalkyl group; each R11, independently, is H, an unsubstituted C1-C6 linear or branched alkyl group, or an unsubstituted C5-C8 cycloalkyl group; each R12, independently, is H, an unsubstituted C1-C6 linear or branched alkyl group, or an unsubstituted C5-C8 cycloalkyl group; x is an integer from 0 to 3; y is an integer from 0 to 2; and each z, independently, is an integer from 1 to 4.

US Pat. No. 10,793,674

PREPARATION METHOD OF ELECTROCONDUCTIVE POLYIMIDE AND DISPLAY PANEL

SHENZHEN CHINA STAR OPTOE...

1. A preparation method of electroconductive polyimide, comprising:providing aminated carbon nanotubes, wherein diameters of the carbon nanotubes range from 1 nm to 5 nm; and
mixing the aminated carbon nanotubes with diamine and dianhydride in a predetermined mass ratio to form a mixture at a first reaction temperature and performing a reflux condensation on vapors of the mixture for a first time, such that the aminated carbon nanotubes react with the diamine and the dianhydride to generate the electroconductive polyimide with alignment;
wherein the first reaction temperature is 220° C.-250° C.

US Pat. No. 10,793,673

BIOADVANTAGED NYLON: POLYCONDENSATION OF 3-HEXENEDIOIC ACID WITH HEXAMETHYLENEDIAMINE

IOWA STATE UNIVERSITY RES...

1. A homopolymer having the structure of formula (I):whereinis a repeating group of the homopolymer;X is NH or O;
R is independently selected from the group consisting of H and C1-20 alkyl;
R1, R2, R3, and R4 are independently selected from the group consisting of H and

with the proviso that at least one of R1, R2, R3, or R4 is not hydrogen;
U is optional and, if present, is —(S)p—;
*- is a point of attachment to formula (I) or R1, R2, R3, or R4;
is a terminal group of the polymer;k is 1 to 1,000,000;
p is 1 to 8;
z is 45.8 to 10,000,000; and
s is 1 to 50;
or a salt thereof.

US Pat. No. 10,793,672

ALKOXYLATED BIO-OIL POLYOL COMPOSITIONS

Battelle Memorial Institu...

1. An alkoxylated bio-oil polyol, the alkoxylated bio-oil polyol being produced by a process comprising alkoxylation of a bio-oil polyol at a temperature between about 80 degree Celsius (° C.) and about 180° C. in the presence of a cyclic alkylene oxide, the alkoxylated bio-oil polyol being characterized compared to the bio-oil polyol by one or more of: a reduced viscosity; an increased molecular weight; a lower gel permeation chromatography retention time; a weight percentage increase over a weight of the bio-oil polyol; and a reduced hydroxyl value; wherein the bio-oil is obtained from reaction of a bio-oil with a reagent polyol and the bio-oil is obtained from the pyrolysis of wood or other lignocellulosic-containing biomass.

US Pat. No. 10,793,670

SYNTHESIS OF TYROSINE DERIVED POLYARYLATES

MEDTRONIC, INC., Minneap...

1. A method for preparing a polyarylate having the formula:
the method comprising:
combining a desaminotyrosyl-tyrosine ethyl ester having the formula:

a desaminotyrosyl-tyrosine benzylester having the formula:

succinic acid and a catalyst in a flask to produce a first mixture;
adding methylene chloride to the first mixture to produce a first suspension;
adding diisopropylcarbodiimide (DIPC) to the first mixture to produce a first solution;
adding the first solution to a non-solvent to polymerize the desaminotyrosyl-tyrosine ethyl ester and the desaminotyrosyl-tyrosine ethyl ester and produce a precipitate;
dissolving the precipitate in methylene chloride to form a polymer solution;
blending the polymer solution with a slurry of 2-propanol and dry ice to produce polymer shreds; and
blending the polymer shreds with a second slurry of 2-propanol and dry ice to produce the polyarylate.

US Pat. No. 10,793,669

PROCESS FOR PRODUCING POLYETHER KETONE KETONE

ARKEMA FRANCE, Colombes ...

1. A method for the manufacture of polyether ketone ketone (PEKK), comprising:(i) providing a 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex;
(ii) purifying said 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex;
(iii) reacting said 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex with at least one difunctional aromatic acyl chloride in a reaction solvent and optional additional Lewis acid to obtain a product mixture comprising a PEKK-Lewis acid complex; and
(iv) decomplexing the PEKK-Lewis acid complex to obtain a PEKK polymer.

US Pat. No. 10,793,668

NAPHTHOINDACENODITHIOPHENES AND POLYMERS

CLAP Co., Ltd., Seoul (K...

1. A polymer comprising a unit of formula 1:
wherein:
n is 0, 1, 2, 3, or 4;
m is 0, 1, 2, 3, or 4;
R is selected from the group consisting of hydrogen, C1-30-alkyl, and phenyl;
L1 and L2 are each independently selected from the group consisting of C6-30-arylene, 5 to 30 membered heteroarylene,

wherein C6-30-arylene and 5 to 30 membered heteroarylene are optionally substituted with one to six substituents R3 selected from the group consisting of C1-30-alkyl, C2-30-alkenyl, C2-30-alkynyl, C5-12-cycloalkyl, C6-18-aryl and 5 to 20 membered heteroaryl, OR31, OC(O)—R31, C(O)—OR31, C(O)—R31R32, NR31—C(O)R32,C(O)—NR31R32, N[C(O)R31][C(O)R32], SR 31, halogen, CN, SiRSivRSiwRSix and OH,
wherein
are optionally substituted with one or two substituents R4 selected from the group consisting of C1-30-alkyl, C2-30-alkenyl, C2-30-alkynyl, C5-12-cycloalkyl, C6-18-aryl and 5 to 20 membered heteroaryl, C(O)—R41, C(O)—NR41R42, C(O)—OR41and CN,wherein, in R31, R32, R41, and R42, are each independently selected from the group consisting of H, C1-30-alkynyl, C2-30-alkenyl, C2-36-alkynyl, C5-12, -cycloalkyl, C6-18-aryl and 5 and 20 membered heroaryl,
wherein, in R31, R32, R41, are each independently selected from the group consisting of H, C1-30-alkyl, C2-30-alkenyl and C2-30-alkynyl C5-12- cycloalkyl, C6-18-aryl and 5 to 20 membered heteroaryl,
wherein, in R31, R32, R41, and R42, C5-12-cycloalkyl is optionally substituted with one to six substituents independently selected from the group consisting of C1-20-alkyl, C2-20-alkenyl and C2-20-alkynyl, C5-8-cycloalkyl, C6-14-aryl, 5 to 14 membered heteroaryl, ORi, OC(O)—Rj, C(O)—ORi, C(O)—Ri, NRiRj, NRi—C(O)Rj, C(O)—NRiRj, N[C(O)Ri][C(O)Rj], SRi, halogen, CN, SiRSivRSiwRSix and NO2: and one or two CH2-groups, but not adjacent CH2-groups, of C5-12-cycloalkyl are optionally replaced by O, S, OC(O), CO, NRior NRi—CO,
wherein, in R31, R32, R41, and R42, C6-18-aryl and 5 to 20 membered heteroaryl are optionally substituted with one to six substituents independently selected from the group consisting of C1-20-alkyl, C2-20-alkenyl, C2-20-alkynyl, C5-8-cycloalkyl, C6-14-aryl, 5 to 14 membered heteroaryl, ORi, OC(O)—Rj, C(O)—ORi, C(O)—Ri, NRiRj, NRi—C(O)Rj, C(O)—NRiRj, N[C(O)Ri][C(O)Rj], SRi, halogen, CN, SiRsivRSiwRSixand NO2,
wherein, in R31, R32, R41, and R42, C1-30-alkyl, C2-30-alkenyl and C2-30-alkynyl are optionally substituted with one to ten substituents independently selected from the group consisting of C5-8-cycloalkyl, C6-14-aryl, 5 to 14 membered heteroaryl, ORi, OC(O)—Rj, C(O)—ORi, C(O)—Ri, NRiRj, NRi—C(O)Rj, C(O)—NRiRj, N[C(O)Ri][C(O)Rj], SRi, halogen, CN, SiRSivRSiwRSix and NO2; and at least two CH2-groups, but not adjacent CH2-groups of C1-30-alkyl, C2-30-alkenyl and C2-30-alkynyl are optionally replaced by O or S,
wherein, in R31, R32, R41, and R42, C5-12-cycloalkyl is optionally substituted with one to six substituents independently selected from the group consisting of C1-20-alkyl, and C2-20-alkeynyl and C2-20-alkynyl, C5-8-cycloalkyl, C6-14-aryl, 5 to 14 membered heteroaryl, ORi, OC(O)—Rj, C(O)—ORi, C(O)—Ri, NRiRj, NRi—C (O)Rj, C(O)—NRiRj, N[C(O)RiC(O)Ri], SRi, halogen, CN, SiRSivRSiwRSix and NO2: and one or two CH2-groups, but not adjacent CH2-groups, of C5-12-cycloalkyl are optionally replaced by O, S, OC(O), CO, NRi or NRi—CO,
wherein, in R31, R32, R41, and R42, C6-18-aryl and 5 to 20 membered heteroaryl are optionally substituted with one to six substituents independently selected from the group consisting of C1-20-alkyl, C2-20-alkenyl, C2-20-alkynyl, C5-8-cycloalkyl, C6-14-aryl, 5 to 14 membered heteroaryl, ORi, OC(O)—Rj, C(O)—ORi, C(O)—Ri, NRiRj, NRi—C(O)Rj, C(O)—NRiRj, N[C(O)Ri][C(O)Rj], SRi, halogen, CN, SiRSivRSiwRSix and NO2,
wherein RSiv, RSiw, and RSix are each independently selected from the group consisting of H, C1-20-alkyl, C2-20-alkenyl, C2-20-alkynyl, C5-6-cycloalkyl, phenyl and O-Si(CH3)3,
wherein Ri, Rjare each independently selected from the group consisting of H, C1-20-alkyl, C2-20-alkenyl, C2-20-alkynyl, C5-8-cycloalkyl, C6-14-aryl, and 5 to 14 membered heteroaryl,
wherein, in RSiv, RSiw, RSix, Ri, Rj, C1-20-alkyl, C2-20-alkenyl and C20-alkynyl are optionally substituted with one to five substituents selected from the group consisting of C5-6-cycloalkyl, C6-10-aryl, 5 to 10 membered heteroaryl, ORk, OC(O)—R1, C(O)—ORk, C(O)—Rk, NRkR1, NRk—C(O)R1, C(O)—NRkRl, N[C(O)Rk][C(O)R1], SRk, halogen, CN, and NO2,
wherein, in RSiv, RSiw, RSix, Ri, and Rj, C5-8-cycloalkyl is optionally substituted with one to five substituents selected from the group consisting of C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C5-6-cycloalkyl, C6-10-aryl, 5 to 10 membered heteroaryl, ORk, OC(O)—Rl, C(O)—ORk, C(O)—Rk, NRkRl, NRk—C(O)Rl, C(O)—NRkR1, N[C(O)Rk][C(O)R1], SRk, halogen, CN, and NO2.
wherein, in RSiv, RSiw, RSix, Ri, and Rj, C6-14-aryl and 5 to 14 membered heteroaryl are optionally substituted with one to five substituents independently selected from the group consisting of C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C5-6-cycloalkyl, C6-10-aryl, 5 to 10 membered heteroaryl, ORk, OC(O)—R1, C(O)—ORk, C(O)—Rk, NRkRl, NRk—C(O)R1, C(O)—NRkR1, N[C(O)Rk][C(O)Rl], SRk, halogen, CN, and NO2,
wherein Rk and Rl, are independently selected from the group consisting of H, C1-10-alkyl, C2-10-alkenyl and C2-10-alkynyl, and
wherein, in Rk and Rl, C1-10-alkyl, C2-10-alkenyl and C2-10-alkynyl are optionally substituted with one to five substituents selected from the group consisting of halogen, CN and NO2.

US Pat. No. 10,793,666

POLYISOCYANATE COMPOSITION, POLYURETHANE RESIN AND TWO-COMPONENT CURABLE POLYURETHANE COMPOSITION

MITSUI CHEMICALS, INC., ...

1. A polyisocyanate composition comprising an isocyanurate derivative of xylylene diisocyanate, anda biuret derivative of aliphatic polyisocyanate,
wherein in a chromatogram of the isocyanurate derivative of xylylene diisocyanate in gel permeation chromatograph measurement, the ratio of the peak area having a peak top between polystyrene-based molecular weight of 400 to 1000 relative to a total peak area is 35% or more and 80% or less, and
wherein relative to 100 parts by mass of a total amount of the polyisocyanate composition,
5 to 25 parts by mass of the isocyanurate derivative of xylylene diisocyanate is contained, and
95 to 75 parts by mass of the biuret derivative of aliphatic polyisocyanate is contained.

US Pat. No. 10,793,662

NITROGEN-CONTAINING COMPOUNDS SUITABLE FOR USE IN THE PRODUCTION OF POLYURETHANES

Evonik Operations GmbH, ...

1. A process for making a polyurethane comprising (1) mixing in a reaction mixture of a polyisocyanate and a polyol a proportion by mass of from 0.01 to 20 parts (pphp), based on 100 parts (pphp) of polyol component of at least one nitrogen compound, or mixtures of the nitrogen compound with corresponding quaternized and/or protonated compounds, wherein this nitrogen compound satisfies formula (VI),with n=2-12 except for 4, and (2) a pyrrolidine group selected from the group consisting of 1-(2-hydroxyethyl)pyrrolidine, 1-(2-chloroethyl)pyrrolidine, and 1-(2-(pyrrolidin-1-yl)propoxy)propan-2-ol.

US Pat. No. 10,793,660

MACROMONOMER COPOLYMER AND METHOD FOR PRODUCING SAME

Mitsubishi Chemical Corpo...

1. A macromonomer copolymer (Y), comprising:a monomer unit of a macromonomer (A) represented by Formula (1); and
a monomer unit of a comonomer (B) copolymerizable with the macromonomer (A),
wherein a value of Hx represented by Expression (2) is 0.05 to 0.40, and a content of a polymer composed only of the monomer unit of the comonomer (B) which is contained in the macromonomer copolymer (Y) is 10% by mass or less with respect to a total mass of the macromonomer copolymer (Y),

wherein in the Formula (1):
R and R1 to Rn are each independently a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group,
X1 to Xn are each independently a hydrogen atom or a methyl group,
Z is a terminal group, and
n is a natural number of 2 to 10,000,
Hx=Hm/Ht  (2)
wherein in Expression (2):
Hm is a proton-integrated value of a terminal double bond group at a trans position in 1H-NMR in a case where X1 in General Formula (1) is a methyl group, and Ht is a proton-integrated value of a terminal double bond group at a trans position in 1H-NMR in a case where X1 in Formula (1) is a methyl group and a hydrogen atom.

US Pat. No. 10,793,653

PROCESS FOR PREPARING CONJUGATED DIENE (CO)POLYMERS IN THE PRESENCE OF A CATALYTIC SYSTEM COMPRISING A PYRIDYL IRON (III) COMPLEX

Versalis S.P.A., San Don...

1. Process for preparing conjugated diene (co)polymers comprising polybutadiene comprising (co)polymerizing at least one conjugated diene in the presence of a catalytic system comprising:(a) at least one pyridyl iron (III) complex having general formula (I) or (II):

wherein:
R1, R2, R3 and R4, identical or different, represent a hydrogen atom; or are selected from a linear or branched, optionally halogenated C1-C20 alkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aryl group;
R5 represents a hydrogen atom, or is selected from a linear or branched, optionally halogenated C1-C20 alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group;
X, identical or different, represent a halogen atom; or are selected from a linear or branched C1-C20 alkyl group, an —OCOR6 group or an —OR6 group wherein R6 is selected from a linear or branched C1-C20 alkyl group;
n is 3;
(b) at least one co-catalyst selected from the following organo-aluminum derivatives:
(b1) aluminum compounds having general formula (III):
Al(R7)(R8)(R9) (III)
wherein R7 represents a hydrogen atom, or is selected from a linear or branched C1-C20 alkyl group, a cycloalkyl group, an aryl group, an alkylaryl group, an arylalkyl group or an alkoxy group; Rs and R9, identical or different, are selected from a linear or branched C1-C20 alkyl group, a cycloalkyl group, an aryl group, an alkylaryl group or an arylalkyl group;
(b2) aluminoxanes having general formula (IV):
(R10)2—Al—O—[—Al(R11)—O-]m-Al—(R12)2  (IV)
wherein R10, R11 and R12, identical or different, represent a hydrogen atom, or a halogen atom, or are selected from a linear or branched C1-C20 alkyl group, a cycloalkyl group or an aryl group, said groups being optionally substituted with one or more silicon or germanium atoms; and m is an integer ranging from 0 to 1000;
(b3) partially hydrolyzed organo-aluminum derivatives;
(b4) haloaluminum alkyls having general formula (V) or (VI):
Al(R13)p(X?)3-p  (V)
Al2(R13)q(X?)3-q  (VI)
wherein p is 1 or 2; q is an integer ranging from 1 to 5; R13, identical or different, are selected from a linear or branched C1-C20 alkyl group; X? represents a chlorine or bromine atom;
wherein polybutadiene obtained has a higher content of 1,2 unit than 1,4 cis unit.

US Pat. No. 10,793,652

SOLID PMAO COMPOSITION AND METHOD FOR PRODUCING SAME

Tosoh Finechem Corporatio...

1. A method for producing a solid PMAO composition, comprising:(a) a step of heating an aromatic hydrocarbon solution (liquid PMAO composition A) containing a poly-methylaluminoxane containing a unit represented by a following general formula (I) (hereinafter sometimes referred to as PMAO) and trimethylaluminum (hereinafter sometimes referred to as TMAL) to precipitate a solid PMAO composition containing the PMAO and TMAL,
wherein a precipitation amount of the solid PMAO composition in the step (a) being 70% or more based on aluminum of the PMAO and TMAL contained in the liquid PMAO composition A;
(b) a step of adding an aromatic hydrocarbon solution (liquid PMAO composition B) containing a PMAO containing a unit represented by the following general formula (I) and TMAL to a solution containing the solid PMAO composition obtained in the step (a); and
(c) a step of heating the solution obtained in the step (b) to precipitate a solid PMAO composition,
wherein a precipitation amount of the solid PMAO composition in the step (c) being 70% or more based on aluminum of the PMAO and TMAL contained in the liquid PMAO compositions A and B,
a median diameter d2 of the solid PMAO composition produced in the step (c) is larger than a median diameter d1 of the solid PMAO composition produced in the step (a), and a heating temperature in the step (c) is the same as or different from a heating temperature in the step (a);
[C1]
[(Me)AlO]n—  (I)
In the formula, n represents an integer of 10 to 50.

US Pat. No. 10,793,651

POLYETHYLENE RESIN HAVING EXCELLENT IMPACT STRENGTH

LG Chem, Ltd., (KR)

1. Polyethylene resin comprising ethylene polymer or (co)polymer of ethylene and alpha olefin, and having a spreading gradient value of 5 to 10 (×106 Pa/m),wherein the spreading gradient value means an average gradient between a minimum point and a second maximum point in a stress-strain curve, measured by ASTM D 638,
wherein the minimum point is a point where strain begins again according to stress increase after passing a yield point in a stress-strain curve, measured by ASTM D 638, and
wherein the second maximum point is a point where ultimate tensile strength (UTS) is reached in a stress-strain curve, measured by ASTM D 638.

US Pat. No. 10,793,646

ADHESIVE COMPOSITIONS COMPRISING TYPE-II CELLULOSE

Renmatix, Inc., King of ...

1. A wood adhesive comprising:an adhesive resin; and
cellulose;
wherein at least about 20 wt. % of the cellulose is type-II cellulose;
and further comprising lignin.

US Pat. No. 10,793,644

ANTIBODIES TO RISPERIDONE HAPTENS AND USE THEREOF

JANSSEN PHARMACEUTICA NV,...

1. A method of detecting risperidone in a sample, the method comprising:(i) generating an antibody or a binding fragment thereof that specifically binds to risperidone in response to a conjugate of a compound of Formula I and an immunogenic carrier,
Formula I:

wherein:
R1 is H, or OH;
R2 is

or O(CH2)rNHC(O)(CH2)mCO2H;
wherein:
r is 1, 2, 3, 4, or 5;
m is 1, 2, 3, 4, or 5; and
n is 1, 2, 3, 4, or 5;
(ii) contacting a sample with the antibody or the binding fragment thereof labeled with a detectable marker, wherein the labeled antibody or the labeled binding fragment and risperidone present in the sample form a labeled complex; and
(iii) detecting the labeled complex thereby detecting risperidone in the sample.

US Pat. No. 10,793,631

HUMAN PAC1 ANTIBODIES

AMGEN INC., Thousand Oak...

1. A method for treating headache in a patient in need thereof, comprising administering to the patient an isolated monoclonal antibody comprising (i) a heavy chain variable region comprising complementarity determining regions CDRH1, CDRH2, and CDRH3, and (ii) a light chain variable region comprising complementarity determining regions CDRL1, CDRL2, and CDRL3, wherein CDRH1, CDRH2, and CDRH3 comprise the sequence of SEQ ID NOs: 230, 235, and 244, respectively, and CDRL1, CDRL2, and CDRL3 comprise the sequence of SEQ ID NOs: 198, 210, and 216, respectively, and wherein the monoclonal antibody specifically binds to human pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1).

US Pat. No. 10,793,605

CONFORMATIONALLY-PREORGANIZED, MINIPEG-CONTAINING ?-PEPTIDE NUCLEIC ACIDS

CARNEGIE MELLON UNIVERSIT...

1. A peptide nucleic acid (PNA) monomer having the following formula:
wherein
B is adenine, guanine, cytosine, thymine, or uracil;
P is selected from the group consisting of hydrogen (H), 9-fluorenylmethyloxycarbonyl (Fmoc), t-butyloxycarbonyl (Boc), benzyloxycarbonyl (Cbz), benzyl (Bn), tosylate (Tos), allyloxycarbonyl (alloc), benzhydryloxycarbonyl (Bhoc), trityl (Trt), monomethoxytrityl (MMT) and dimethoxytrityl (DMT);
each of R1 and R2 is independently selected from the group consisting of hydrogen (H), linear or branched (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxylalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene, (C3-C8)cycloalkyl(C1-C6)alkylene, and

provided that at least one of R1 and R2 is

each of R3 and R4 is independently selected from the group consisting of hydrogen (H) and

R5 is selected from the group consisting of hydrogen (H), linear or branched (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)hydroxylalkyl, (C3-C8)aryl, (C3-C8)cycloalkyl, (C3-C8)aryl(C1-C6)alkylene and (C3-C8)cycloalkyl(C1-C6)alkylene;
R6 is selected from the group consisting of hydrogen (H), linear or branched (C1-C8)alkyl, substituted or unsubstituted (C3-C8)aryl and (C3-C8)aryl(C1-C6)alkylene;
P1 is selected from the group consisting of hydrogen (H), linear or branched (C1-C8)alkyl, 9-fluorenylmethyloxycarbonyl (Fmoc), t-butyloxycarbonyl (Boc), benzyloxycarbonyl (Cbz), benzyl (Bn), tosylate (Tos), allyloxycarbonyl (alloc), trityl (Trt), monomethoxytrityl (MMT) and dimethoxytrityl (DMT);
n is an integer from 0 to 10, inclusive; and
q is an integer from 1 to 10, inclusive.

US Pat. No. 10,793,604

ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS

BOEHRINGER INGELHEIM ANIM...

1. A method for the treatment or prevention of a parasitic infection or infestation in an animal comprising administering a parasiticidally effective amount of an anthelmintic cyclic depsipeptide of formula (I), or a pharmaceutically or veterinarily acceptable salt thereof, to the animal:
wherein:
Cy1 and Cy2 are independently aryl, carbocyclic, heteroaryl or heterocyclic optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, thioamido, amino, alkylamino, dialkylamino, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, SF5, R5S(O)—, R5S(O)2—, R5C(O)—, R5R6NC(O)—, R5R6NC(O)NR5—, R5OC(O)—, R5C(O)O—, R5C(O)NR6—, —CN, —NO2, cycloalkyl, heteroalkyl, heterocyclyl, aryl, heteroaryl, —O-heteroaryl, —S-heteroaryl, —O— heterocyclyl and —S-heterocyclyl, wherein each cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted with one or more substituents selected from the group consisting of halogen, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, thioamido, amino, alkylamino, dialkylamino, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, SF5, R5S(O)—, R5S(O)2—, R5C(O)—, R5R6NC(O)—, R5OC(O)—, R5C(O)O—, R5C(O)NR6—, —CN and —NO2;
R5 and R6 are independently hydrogen, alkyl, haloalkyl, thioalkyl, alkylthioalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, or the group —CH2C(O)NHCH2CF3; or R5 and R6 together with the atom(s) to which they are bonded form a C3-C6 cyclic group;
R?, R?, R?? and R?? are each independently hydrogen or C1-C3alkyl;
Ra and Rb are independently hydrogen, C1-C3alkyl or C1-C3haloalkyl; and
(a) R1 is C1-C8 alkyl substituted by one or more halogen; and
R2, R3 and R4 are each independently C1-C8 alkyl; or
(b) R2 is C1-C8 alkyl substituted by one or more halogen; and
R1, R3 and R4 are each independently C1-C8 alkyl; or
(c) R3 is C1-C8 alkyl substituted by one or more halogen; and
R1, R2 and R4 are each independently C1-C8 alkyl; or
(d) R4 is C1-C8 alkyl substituted by one or more halogen; and
R1, R2 and R3 are each independently C1-C8 alkyl; or
(e) R1 and R2 are each independently C1-C8 alkyl substituted by one or more halogen; and
R3 and R4 are each independently C1-C8 alkyl; or
(f) R1 and R3 are each independently C1-C8 alkyl substituted by one or more halogen; and
R2 and R4 are each independently C1-C8 alkyl; or
(g) R1 and R4 are each independently C1-C8 alkyl substituted by one or more halogen; and
R2 and R3 are each independently C1-C8 alkyl; or
(h) R2 and R4 are each independently C1-C8 alkyl substituted by one or more halogen; and
R1 and R3 are each independently C1-C8 alkyl; or
(i) R2 and R3 are each independently C1-C8 alkyl substituted by one or more halogen; and
R1 and R4 are each independently C1-C8 alkyl; or
(j) R3 and R4 are each independently C1-C8 alkyl substituted by one or more halogen; and
R1 and R2 are each independently C1-C8 alkyl; or
(k) R1, R2 and R3 are each independently C1-C8 alkyl substituted by one or more halogen; and
R4 is C1-C8 alkyl; or
(l) R2, R3 and R4 are each independently C1-C8 alkyl substituted by one or more halogen; and
R1 is C1-C8alkyl; or
(m) R1, R3 and R4 are each independently C1-C8 alkyl substituted by one or more halogen; and
R2 is C1-C8 alkyl; or
(n) R1, R2 and R4 are each independently C1-C8 alkyl substituted by one or more halogen; and
R3 is C1-C8 alkyl; or
(o) R1, R2, R3 and R4 are each independently C1-C8 alkyl substituted by one or more halogen.

US Pat. No. 10,793,603

POLYSACCHARIDE DERIVATIVE HAVING MEMBRANE-PERMEABLE PEPTIDE CHAIN

JOSHO GAKUEN EDUCATIONAL ...

1. A polysaccharide derivative having a structure represented by one of Formulae (3) to (5) below:
wherein X1 represents a residue obtained by removing a terminal amino group and a terminal carboxyl group from a neutral amino acid or an ?-aminoalkanoic acid, X2 represents a residue obtained by removing a terminal amino group and a terminal carboxyl group from a membrane-permeable peptide, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, and b represents a number of from 0 to 50;
c and d represent numbers satisfying the condition that c+d is such that the polysaccharide derivative represented by Formula (3) has a weight-average molecular weight of 5,000 to 50,000,000 and d/(c+d) is such that a ratio of the partial structures represented by Formula (2) below to the total saccharide units in said polysaccharide derivative is from 0.29 to 0.8;

wherein X1 to X3 and b are as defined in Formulae (3) to (5) and * represents a bonding hand;
e, f and g represent numbers satisfying the condition that e+f+g is such that the polysaccharide derivative represented by Formula (4) has a weight-average molecular weight of 5,000 to 50,000,000 and g/(e+f+g) is such that a ratio of the partial structures represented by Formula (2) to the total saccharide units in said polysaccharide derivative is from 0.29 to 0.8; and
h, j, k and m represent numbers satisfying the condition that h+j+k+m is such that the polysaccharide derivative represented by Formula (5) has a weight-average molecular weight of 5,000 to 50,000,000 and (k+m)/(h+j+k+m) is such that a ratio of the partial structures represented by Formula (2) to the total saccharide units in said polysaccharide derivative is from 0.29 to 0.8.

US Pat. No. 10,793,600

CYSTOBACTAMIDES

1. A method for treatment or prophylaxis of bacterial infections comprising administering a pharmaceutical composition,wherein the pharmaceutical composition comprises a compound of formula (V)

wherein
R51 is a hydrogen atom, or a C1-6 alkyl group;
R52 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl;
R53 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl;
R54 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl;
R55 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl;
D is N or CR56;
E is N or CR57;
G is N or CR58;
M is N or CR59;
R56 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl;
R57 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl;
R58 is a hydrogen atom, F, Cl, a hydroxy group, a C1.6 alkyl group or a group of formula —O—C1-6 alkyl;
R59 is a hydrogen atom, F, Cl, a hydroxy group, a C1-6 alkyl group or a group of formula —O—C1-6 alkyl; and
Ar6 is an optionally substituted phenyl group or an optionally substituted heteroaryl group having 5 or 6 ring atoms including 1, 2, 3 or 4 heteroatoms selected from oxygen, sulphur and nitrogen;
with the proviso that Ar6 is substituted by a group of formula —NHR8; wherein R8 is a group of the following formula:

wherein R9 is COOH or CONH2 and R10 is COOH or CONH2;
or a pharmaceutically acceptable salt, or a pharmaceutically acceptable formulation thereof.

US Pat. No. 10,793,595

TOLL-LIKE RECEPTOR 2 LIGANDS AND METHODS OF MAKING AND USING THEREOF

H. LEE MOFFITT CANCER CEN...

1. A compound having Formula I:
wherein
L is a bond, H, R14, C(O)R14C(O), C(O)OR14OC(O), C(O)R14N, C(O)OR14NH, NHR14NH, or C(O)NHR14NHC(O), C(S)OR14OC(S), —(CO—R14)2NH, —(R14)2NH, —(SO2R14)2NH, —(SOR14)2NH, —(OR14)2NH, —(O—CO—R14)2NH, —(CO—O—R14)2NH, —(CO-R14)2CH2, —(R14)2CH2, —(SO2R14)2CH2, —(SOR14)2CH2, —(O—CO—R14)2CH2, or —(OR14)2CH2, wherein R14 is O, S, C1-C20 alkyl; or
L is C1-C20 heteroalkyl, C1-C20 alkylamine, C1-C20 alkoxyl, C1-C20 alkanoyloxyl, or C1-C20 alkylamido, any of which are optionally substituted with one or more halogen, alkoxyl, alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl, heteroaryl, amine, cyano, nitro, hydroxyl, carbonyl, acyl, —COOH, —C(O)R12, —C(O)OR12, —COO-, —CONH2, —CONHR12, —C(O)NR12R13, —NR12R13, —NR12S(O)2R13, —NR12C(O)R13, —S(O)2R12, —SR12, —S(O)2NR12R13, —SOR12, and —SOOR12; wherein R12 and R13 each is independently hydrogen, halogen, hydroxyl, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, carbonyl, cyano, amino, alkylamino, dialkylamino, alkoxyl, aryloxyl, cycloalkyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, or dialkylaminocarbonyl;
R1 is an imaging moiety selected from the group consisting of UV-Vis moiety, a near-infrared moiety, a luminescent moiety, a phosphorescent moiety, a magnetic spin resonance moiety, a photosensitizing moiety, a photocleavable moiety, a chelator, a heavy atom, a radioactive isotope, an isotope detectable spin resonance moiety, a paramagnetic moiety, a chromophore, or any combination thereof;
AA is 1 to 2 amino acid residues; and
HP is a hydrophilic polymer selected from the group consisting of PVA, PEG, polyacrylamide, acetates, PEO, PEA, PVP, PDX, and combinations thereof;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,793,594

ANTIMICROBIAL COMPOUNDS AND/OR MODULATORS OF MICROBIAL INFECTIONS AND METHODS OF USING THE SAME

Indiana University Resear...

1. A compound, wherein the compound is at least one enantiomer of at least one compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof, or a metabolite thereof, or wherein the compound is,
or a pharmaceutically acceptable salt thereof, or a metabolite thereof.

US Pat. No. 10,793,591

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Janssen BioPharma, Inc., ...

1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof,having the structure:wherein:
B1 is selected from the group consisting of
R1 is selected from the group consisting of an unsubstituted C1-6 alkyl and an unsubstituted C2-6 alkynyl;
each -------- is absent;
R2 is fluoro;
RP is absent;
R3 is —OH;

R4 is hydrogen or

R5A is selected from the group consisting of OH,
R5B is selected from the group consisting of an OH, —O-unsubstituted phenyl, —O— unsubstituted naphthyl,

R6C is selected from the group consisting of hydrogen and an unsubstituted C1-6alkyl;
R6F is NHR6I;
R6I is hydrogen;
R11A, R12A, R11B and R12B are each hydrogen;
R13 is selected from the group consisting of an unsubstituted C1-6 alkyl and an unsubstituted C3-6 cycloalkyl;
R14 and R15 are each independently selected from the group consisting of hydrogen and an unsubstituted C1-6 alkyl;
R13A and R13B are each an unsubstituted —O-C1-4 alkyl;
n is 0 or 1;
R9, R10 and R11 are each hydrogen; and
Z1, Z1A and Z1B are each O.

US Pat. No. 10,793,590

ANTIFUNGAL COMPOUNDS

President and Fellows of ...

1. A compound having a structure of Formula I or Formula II or a pharmaceutically acceptable salt thereof:
wherein
R1 and R2 are, independently for each occurrence, H or OR23, or R1 and R2 together with the carbon to which they are bound form a carbonyl moiety;
R3 and R4 are, independently for each occurrence, H or OR23, or R3 and R4 together with the carbon to which they are bound form a carbonyl moiety;
R5 and R6 are, independently for each occurrence, H or OR23, or R5 and R6 together with the carbon to which they are bound form a carbonyl moiety;
R7 and R8 are, independently for each occurrence, H or OR23, or R7 and R8 together with the carbon to which they are bound form a carbonyl moiety;
R9, R10, R11, R12, R13, R14, R15, and R16 are, independently for each occurrence, H or OR23;
R17, R18, R19, R20, R21, and R22 are, independently for each occurrence, H or optionally substituted alkyl;
R23 is, independently for each occurrence, H, optionally substituted alkyl, or optionally substituted acyl; and
R24 is, independently for each occurrence, H, optionally substituted alkyl, or optionally substituted acyl.

US Pat. No. 10,793,589

RESORCINARENE-BASED AMPHIPATHIC COMPOUND AND USE THEREOF

Industry-University Coope...

1. A compound represented by the following Formula 1 or Formula 2:
wherein R1 to R4 are each independently a substituted or unsubstituted C3-C30 alkyl group, a substituted or unsubstituted C3-C30 cycloalkyl group, or a substituted or unsubstituted C3-C30 aryl group;
X1 to X8 are saccharides; and
m1 to m8 are 0, 1, or 2,

wherein R1 to R4 are each independently a substituted or unsubstituted C2-C30 alkyl group, a substituted or unsubstituted C3-C30 cycloalkyl group, or a substituted or unsubstituted C3-C30 aryl group;
X1 to X4 are saccharides; and
m1 to m4 are 0, 1, or 2.

US Pat. No. 10,793,588

CRYSTAL FORM OF SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITOR

JI LIN HUI SHENG BIO-PHAR...

1. Crystalline Form I of a co-crystal of the compound of Formula (1) with L-proline, wherein the compound of Formula (1) is (2S,3R,4R,5S,6R)-2-(3-(4-(((1R,3s,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)benzyl)-4-chlorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, the compound of Formula (1) with L-proline are present in a molar ratio of 1:2,the crystalline Form I exhibits an X-ray powder diffraction pattern having characteristic peaks at the 2? positions of 4.0±0.2°, 17.9±0.2°, 18.5±0.2° and 19.7±0.2°, as determined by using Cu-K? radiation,

US Pat. No. 10,793,586

QUATERNARY AMMONIUM ETIDRONATES

INNOVATIVE WATER CARE, LL...

1. A quaternary ammonium etidronate compound, comprising a quaternary ammonium cation and an etidronate anion, having the Formula I,
wherein in the quaternary ammonium cation in the Formula I,
R1 or R2, is a H or a substituted or unsubstituted straight chain or branched C1-C8 alkyl, aryl, alkylaryl/arylalkyl, cycloalkyl, (aromatic or non-aromatic) heterocyclyl, or alkoxy;
R3 or R4 is a substituted or unsubstituted straight chain or branched C6-C30 alkyl, aryl, alkylaryl/arylalkyl, cycloalkyl, (aromatic or non-aromatic) heterocyclyl, alkenyl, phenyl, alkyl-substituted phenyl, benzyl, naphthylmethyl, or ethylbenzyl group;
wherein two or more of R1, R2, R3 and R4 may together with a nitrogen atom form a substituted or unsubstituted heterocyclic ring; and wherein the total number of carbon atoms in the groups R1, R2, R3 and R4 must be at least 12;
wherein the quaternary ammonium cation, comprises a C8-C30 dialkyldimethyl ammonium, C8-C30 dialkylmethylpoly(oxyethyl) ammonium, C8-C30 alkylbenzyldimethyl ammonium, C8-C30 alkyltrimethylammonium, C8-C30 dialkyldihydroxyethyl ammonium, C8-C30 dialkylmethylhydroxyethyl ammonium, or C8-C30 alkylmethyldihydroxyethyl ammonium;
wherein the etidronate anion, having the Formula I, is an etidronic salt wherein R5 and R6 is PO32? or PO3Xy; wherein each X is a H, M, H?, HM, M? or M+; wherein y is 0-2; and M is lithium, sodium, potassium or any combinations thereof, and wherein R7 group is a H or a substituted or unsubstituted straight chain or branched C1-C8 alkyl;
wherein m is 1-4 and n is 1; and
wherein the quaternary ammonium etidronate compound does not comprise a chloride ion.

US Pat. No. 10,793,585

PHOSPHORIC ACID DIESTER SALT, PRODUCTION METHOD THEREFOR, NON-AQUEOUS ELECTROLYTIC SOLUTION FOR POWER STORAGE ELEMENT, AND POWER STORAGE ELEMENT

STELLA CHEMIFA CORPORATIO...

1. A non-aqueous electrolytic solution for a power storage element, comprising, as an additive, a phosphoric acid diester salt represented by the following chemical formula (1):
wherein Mn+ represents a hydrogen ion, an alkali metal ion, an alkali earth metal ion, an aluminum ion, a transition metal ion, or an onium ion; R1 and R2 are different from each other and represent a hydrocarbon group having 1 to 10 carbon atoms, or a hydrocarbon group having 1 to 10 carbon atoms and having at least one of a halogen atom, a heteroatom, and an unsaturated bond; and n represents a valence.

US Pat. No. 10,793,584

NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR

Osaka University, Osaka ...

1. A naphthobischalcogenadiazole derivative represented by a formula (I):
where each of A1 and A2 is independently an oxygen atom, a sulfur atom, a selenium atom, or a tellurium atom; and each of X1 and X2 is independently a boronic acid group, a boronic acid ester group, a boronic acid diaminonaphthalene amide group, an N-methyliminodiacetic acid boronate group, a trifluoroborate salt group, or a triolborate salt group.

US Pat. No. 10,793,583

COMPOUNDS AND METHODS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND/OR CEREBRAL AMYLOID ANGIOPATHY

Amicus Therapeutics, Inc....

1. A compound having a structure represented by formula I:wherein:R1 is H;
R2, R4 are independently chosen from H, C1-C8 alkyl, aryl, (CH2)n aryl, (CH2)n heteroaryl;
n=0-8;
X1 is chosen from CO, SO, SO2, —CONH—, SO2NH—, SONH—;
A1 is OR4.and
A2, B1, B2, C1, C2 are independently chosen from H, OR4, F, wherein at least one of A2, B1, B2, C1 or C2 is F,or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,793,582

BICYCLIC HETEROCYCLIC COMPOUND

MITSUBISHI TANABE PHARMA ...

1. A compound represented by the formula (I):whereinring A is an optionally substituted aromatic group,
X1 is CR1 or a nitrogen atom,
a part represented by the following formula in the formula (I):
is the following A) or B),A) is a double bond,X2 is a nitrogen atom or CR2, and
X3 is a nitrogen atom or CR3;B) is a single bond,X2 is NR2, and
X3 is carbonyl;
X4 is sulfur atom, an oxygen atom or —CH?CH—,
Z1 is an oxygen atom, —C(R6)(R7)—, —NH—, —C(R6)(R7)—NH—, —NH—C(R6)(R7)—, —C(R6)(R7)—O—, —O—C(R6)(R7)— or a single bond (where the left end shows a bond to ring A, and the right end shows a bond to the adjacent carbonyl),
one of Z2 and Z3 is CH and the other is a nitrogen atom, or both are nitrogen atoms,
R1 is a group represented by the following formula (i-a), (i-b) or (i-c):

R2 is a group represented by the following formula (ii-a), (ii-b) or (ii-c):

R3 is a group represented by the following formula (iii-a), (iii-b) or (iii-c):

R4 and R5 are each independently optionally substituted alkyl or optionally substituted cycloalkyl, or
R4 and R5 are bonded to each other to form, together with the adjacent Z2 and Z3, an optionally substituted nitrogen-containing non-aromatic heterocycle,
R6 and R7 are each independently a hydrogen atom, optionally substituted alkyl, or optionally substituted cycloalkyl, or R6 and R7 are bonded to each other to form, together with the adjacent carbon atom, an optionally substituted cycloalkane,
R1a, R1b, R1c, Rld, R2a, R2b, R2c, R2dd R3a, R3b and R3d are each independently a hydrogen atom, optionally substituted alkyl, cyano, a halogen atom, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted non-aromatic heterocyclic group or optionally substituted heteroaryl,
R3c is optionally substituted alkyl, cyano, optionally substituted alkoxy, a halogen atom, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted non-aromatic heterocyclic group or optionally substituted heteroaryl, and
n is 0 or 1, or a pharmacologically acceptable salt thereof, excluding 2-oxazolo[4,5-b]pyridin-2-yl-pyrrolidine-1-carboxylic acid benzyl ester or a pharmacologically acceptable salt thereof.

US Pat. No. 10,793,581

STEREOCHEMICALLY DEFINED POLYPROPIONATES AND METHODS FOR MAKING AND USING THE SAME

1. A compound of Formula 1?:
wherein:
R is hydrogen or —C(O)R1, and
R1 is selected from the group consisting ofC1-C8alkyl, C1-C8alkenyl, aryl, and heteroaryl, R1 may be unsubstituted or substituted from 1 to 3 times with independently selected C1-C6alkyl, hydroxy, hydroxyC1-C6alkyl, methoxy, methoxyC1-C6alkyl, halo, haloC1-C6alkyl, C(O)NH2, NHCOOC1-C6alkyl, or —COOH group(s);or a salt thereof.

US Pat. No. 10,793,580

SUBSTITUTED PYRAZOLOAZEPIN-8-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

1. A Compound of general formula (I)
wherein
R1 and R4 are independently selected from the group consisting of hydrogen and (C1-C4)alkyl;
R2 and R3 are independently selected from the group consisting of hydrogen and (C1-C4)alkyl; or R2 and R3 may together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl, oxetanyl, tetrahydrofuranyl or tetrahydropyranyl ring;
n=0, 1 or 2;
Q is selected from the group consisting of —O—C(O)—R5;
R5 is selected from the group consisting of (C1-C6)alkyl, (C3-C7)cycloalkyl, (4-7)-membered heterocycloalkyl heteroaryl and aryl, wherein said heteroaryl and aryl are optionally substituted with one or more substituents selected from R6, and wherein said (C1-C6)alkyl, (C3-C7)cycloalkyl and (4-7)-membered heterocycloalkyl are optionally substituted with one or more substituents selected from R7;
R6 consists of halogen, cyano, hydroxyl, (C1-C4)alkyl, halo(C1-C4)alkyl, —S(O)2Rx, —S(O)2NRaRb, C(O)NRaRb, —C(O)ORa, —C(O)Rx and —ORx;
R7 consists of halogen, hydroxyl, (C1-C4)alkyl, cyano, oxo, —C(O)NRaRb, —C(O)ORa, —C(O)Rx, S(O)2Rx, —ORx, —SRx, aryl and heteroaryl;
Rx consist of (C1-C6)alkyl, (C3-C6)cycloalkyl;
Ra and Rb are independently selected from the group consisting of hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl and phenyl(C1-C4)alkyl, or
Ra and Rb may together with the nitrogen atom to which they are attached form a 4-6 membered heterocycloalkyl, wherein said heterocycloalkyl is optionally substituted with one or more (C1-C4)alkyl or —C(O)Rx;
or a pharmaceutically acceptable salt, hydrate or solvate thereof.

US Pat. No. 10,793,578

FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

UCB Biopharma SRL, Bruss...

1. A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt thereof:
wherein
G- represents —O—C(O)—N(Rf)—, —N(Rf)—C(O)—N(Rf) or —N(Rf)—S(O)2—N(Rf)—; or -G-represents —N(Rf)—C(O)—CH2—, CH2—N(Rf)—C(O)—, —C(O)—N(Rf)—CH2—, —N(Rg)—CH2—CH2—, —S(O)2—N(Rf)—CH2—, —N(Rf)—S(O)2—CH2—, —O—CH2—CH2—, —S—CH2—CH2—, —S(O)—CH2—CH2—, —S(O)2—CH2—CH2—, —S(O)(N—Rf)—CH2—CH2—, —O—C(O)—CH2—, —O—S(O)2—N(Rf)—, —N(Rf)—C(O)—O—CH2, or —N(Rf)—C?N(Rf)—CH2, any of which groups may be optionally substituted by one or more substituents;
E represents a fused heteroaromatic ring system selected from the groups of formula (Ea), (Eb) and (Ec),

wherein the asterisk (*) represents the site of attachment of E to the remainder of the molecule;
R1 represents hydrogen, halogen, cyano, trifluoromethyl, trifluoromethoxy, —ORa, —SRa, —SORa, —SO2Ra, —NRbRc, —NRcCORd, —NRcCO2Rd, —NHCONRbRc, —NRcSO2Re, —CORd, —CO2Rd, —CONRbRc, —SO2NRbRc or —S(O)(N—Rb)Re; or R1 represents C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkenyl, heteroaryl, heteroaryl(C1-6)alkyl, heteroaryl-aryl, (C3-7)heterocycloalkyl(C1-6)alkyl-aryl-, (C3-7)heterocycloalkenyl-aryl-, (C3-7)cycloalkyl-heteroaryl-, (C3-7)cycloalkyl(C1-6)alkyl-heteroaryl-, (C4-7)cycloalkenyl-heteroaryl-, (C4-9)bicycloalkyl-heteroaryl-, (C3-7)heterocycloalkyl-heteroaryl-, (C3-7)heterocycloalkyl(C1-6)alkyl-heteroaryl-, (C3-7)heterocycloalkenyl-heteroaryl-, (C4-9)heterobicycloalkyl-heteroaryl- or (C4-9)spiroheterocycloalkyl-heteroaryl-, any of which groups may be optionally substituted by one or more substituents;
R2 represents hydrogen, halogen, cyano, nitro, hydroxy, trifluoromethyl, trifluoromethoxy or —ORa; or R2 represents C1-6 alkyl optionally substituted by one or more substituents;
R3 and R4 independently represent hydrogen, halogen or trifluoromethyl; or R3 and R4 independently represent C1-6 alkyl, optionally substituted by one or more substituents;
R5 and R8 independently represent hydrogen, halogen, hydroxy, cyano, trifluoromethyl, difluoromethoxy, trifluoromethoxy, —ORa, or C1-6 alkylsulphonyl; or R5 and R8 independently represent C1-6 alkyl optionally substituted by one or more substituents;
R6 and R7 independently represent hydrogen, halogen, trifluoromethyl, C1-6 alkyl or C1-6 alkoxy;
R12 represents hydrogen or C1-6 alkyl;
Ra represents C1-6 alkyl, C3-7 cycloalkyl, C3-7 heterocycloalkyl, aryl, aryl(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents;
Rb and Rc independently represent hydrogen or trifluoromethyl; or Rb and Rc independently represent C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents; or
Rb and Rc, when taken together with the nitrogen atom to which they are both attached, represent a heterocyclic moiety selected from azetidin-1-yl, pyrrolidin-1-yl, oxazolidin-3-yl, isoxazolidin-2-yl, thiazolidin-3-yl, isothiazolidin-2-yl, piperidin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, piperazin-1-yl, homopiperidin-1-yl, homomorpholin-4-yl, homopiperazin-1-yl, (imino)(oxo)thiazinan-4-yl, (oxo)thiazinan-4-yl and (dioxo)thiazinan-4-yl, any of which groups may be optionally substituted by one or more substituents;
Rd represents hydrogen; or Rd represents C1-6 alkyl, C3-7 cycloalkyl, aryl, C3-7 heterocycloalkyl or heteroaryl, any of which groups may be optionally substituted by one or more substituents;
Re represents C1-6 alkyl, aryl or heteroaryl, any of which groups may be optionally substituted by one or more substituents;
Rf represents hydrogen; or Rf represents C1-6 alkyl, C3-7 cycloalkyl, or C3-7 heterocycloalkyl, C1-6 alkylcarbonyl, C1-6 alkylsulfonyl any of which groups may be optionally substituted by one or more substituents; and
Rg represents hydrogen or (C2-6)alkoxycarbonyl; or Rg represents C1-6 alkyl, C3-7 cycloalkyl, C3-7 heterocycloalkyl, heteroaryl, —CO—(C1-6)alkyl, or —SO2—(C1-6)alkyl, —CO—(C3-7)heterocycloalkyl, —SO2—(C3-)cycloalkyl, —SO2—(C3-7)heterocycloalkyl, —SO2-aryl, or —SO2-heteroaryl, any of which groups may be optionally substituted by one or more substituents.

US Pat. No. 10,793,577

FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE

Akarna Therapeutics, Ltd....

1. A compound having the structure of Formula (IIa), or a pharmaceutically acceptable salt or solvate thereof:
wherein:
R1 is selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C2-C6alkenyl, optionally substituted C2-C6alkynyl, optionally substituted C3-C8cycloalkyl, optionally substituted aryl, optionally substituted —(C1-C2alkylene)-(aryl), optionally substituted C2-C9heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted —(C1-C2alkylene)-(heteroaryl);
R2 is selected from the group consisting of —CN, —C(O)OR25, —C(O)N(R25)R26,
or R1 and R2 together with the carbon atoms to which they are attached, form an optionally substituted C2-C9heterocycloalkyl ring or an optionally substituted heteroaryl ring;R4 and R5 are each independently selected from the group consisting of hydrogen, halogen, optionally substituted C1-C6alkoxy, optionally substituted C1-C6alkyl, optionally substituted C2-C6alkenyl, and optionally substituted C2-C6alkynyl; or R4 and R5 together with the carbon atom to which they are attached, form an optionally substituted C3-C6cycloalkyl ring or an optionally substituted C2-C7heterocycloalkyl ring;
R6 is selected from the group consisting of hydrogen, halogen, optionally substituted C1-C6alkyl, optionally substituted C2-C6alkenyl, optionally substituted C2-C6alkynyl, and —C(O)N(R27)R28;
R7 is selected from the group consisting of hydrogen, halogen, optionally substituted C1-C6alkyl, optionally substituted C1-C6alkoxy, optionally substituted C2-C6alkenyl, and optionally substituted C2-C6alkynyl;
R8 is selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C3-C8cycloalkyl, optionally substituted aryl, optionally substituted —(C1-C2alkylene)-(aryl), optionally substituted heteroaryl, optionally substituted C2-C9heterocycloalkyl, and optionally substituted —(C1-C2alkylene)-(heteroaryl);
each R11 is independently selected from the group consisting of halogen, —CN, amino, alkylamino, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C3-C8cycloalkyl, C2-C9heterocycloalkyl, aryl, heteroaryl, —C(O)OR12, and —C(O)N(R13)R14;
each R12 is independently selected from the group consisting of hydrogen and C1-C6alkyl;
each R13 and R14 are each independently selected from the group consisting of hydrogen and C1-C6alkyl; or R13 and R14 together with the nitrogen atom to which they are attached, form an optionally substituted C2-C9heterocycloalkyl ring;
R25 and R26 are each independently selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C3-C8cycloalkyl, optionally substituted aryl, optionally substituted —(C1-C2alkylene)-(aryl), optionally substituted C2-C9heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted —(C1-C2alkylene)-(heteroaryl);
R27 and R28 are each independently selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C3-C8cycloalkyl, optionally substituted aryl, optionally substituted —(C1-C2alkylene)-(aryl), optionally substituted C2-C9heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted —(C1-C2alkylene)-(heteroaryl); or R27 and R28 together with the nitrogen atom to which they are attached, form an optionally substituted C2-C9heterocycloalkyl ring;
R30 is halogen,

each R31 is independently halogen, —OH, —CN, —NO2, —NH2, optionally substituted C1-C6alkyl, optionally substituted C1-C6alkoxy, optionally substituted C1-C6alkylamine, optionally substituted C3-C8cycloalkyl, optionally substituted C2-C9heterocycloalkyl, aryl, or heteroaryl;
each R32 and R33 are each independently selected from the group consisting of hydrogen, halogen, and C1-C6alkyl;
R34 and R35 are each independently selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C3-C8cycloalkyl, and optionally substituted C2-C9heterocycloalkyl; or R34 and R35 together with the nitrogen atom to which they are attached, form an optionally substituted C2-C9heterocycloalkyl ring;
n is 0, 1, 2, or 3
p is 0, 1, 2, 3, or 4;
r is 0, 1, 2, 3, or 4; and
t is 2, 3, or 4.

US Pat. No. 10,793,576

COMPOUND USED AS BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF

CHENGDU BRILLIANT PHARMAC...

1. A compound, having the structure shown in formula (I) or an isomer, a pharmaceutically acceptable solvate or salt thereof:
wherein Y is a substituted or unsubstituted aryl or heteroaryl;
R is a substituted or unsubstituted alkenyl or alkynyl;
M is

wherein P is CR5R6, N—R7 or O;
R7 is a substituted or unsubstituted C1-8 alkyl, a substituted or unsubstituted C1-8 heteroalkyl, a substituted or unsubstituted C3-8 cycloalkyl, a substituted or unsubstituted C3-8 heterocycloalkyl, or

R5, R6 and R8 are independently selected from the group consisting of substituted or unsubstituted C1-8 alkyls, substituted or unsubstituted C1-8 heteroalkyls, substituted or unsubstituted C3-8 cycloalkyls, and substituted or unsubstituted C3-8 heterocycloalkyls.

US Pat. No. 10,793,575

OXOISOQUINOLINE DERIVATIVES

CARNA BIOSCIENCES, INC., ...

1. An oxoisoquinoline compound of the following formula:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,793,574

TYK2 INHIBITORS AND USES THEREOF

Nimbus Lakshmi, Inc., Ca...

1. A compound of formula VIII:
or a pharmaceutically acceptable salt thereof, wherein:X is C(R3);Y is C(R1);R1 is H, D, or halogen;R2 is —N(R)C(O)Cy2, —N(R)S(O)2Cy2, or —N(R)Cy2;R3 is H or halogen;Cy1 is phenyl or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; wherein Cy1 is substituted with n instances of R5;Cy2 is phenyl; a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 3-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or a 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring; wherein Cy2 is substituted with p instances of R6;Cy3 is a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; wherein Cy3 is substituted with r instances of R8;L1 is —N(R)—;each instance of R4, R5, R6, R7 and R8 is independently RA or RB, and is substituted by q instances of Rc;each instance of RA is independently oxo, halogen, —CN, —NO2, —OR, —ORD, —SR, —NR2, —S(O)2R, —S(O)2NR2, —S(O)R, —S(O)NR2, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)N(R)OR, —OC(O)R, —OC(O)NR2, —N(R)C(O)OR, —N(R)C(O)R, —N(R)C(O)NR2, —N(R)C(NR)NR2, —N(R)S(O)2NR2, or —N(R)S(O)2R;each instance of RB is independently C1-6 aliphatic; phenyl; a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; a 3-7 membered saturated or partially unsaturated carbocyclic ring; a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or a 7-12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;each instance of RC is independently oxo, halogen, —CN, —NO2, —OR, —SR, —NR2, —S(O)2R, —S(O)2NR2, —S(O)R, —S(O)NR2, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)N(R)OR, —OC(O)R, —OC(O)NR2, —N(R)C(O)OR, —N(R)C(O)R, —N(R)C(O)NR2, —N(R)C(NR)NR2, —N(R)S(O)2NR2, or —N(R)S(O)2R or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;RD is a C1-4 aliphatic group wherein one or more hydrogens are replaced by deuterium;each R is independently hydrogen, or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated heterocyclic having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or:two R groups on the same nitrogen are taken together with their intervening atoms to form a 4-7 membered saturated, partially unsaturated, or heteroaryl ring having 0-3 heteroatoms, in addition to the nitrogen, independently selected from nitrogen, oxygen, and sulfur; andeach of m, n, p, q, and r is independently 0, 1, 2, 3, or 4.

US Pat. No. 10,793,573

FIRST-IN-CLASS OF SHMT2 AND MTHFD2 INHIBITORS AS ANTITUMOR AGENTS

Duquesne University of Th...

1. A method of treating a patient having cancer comprising administering a therapeutically effective amount of a compound of Formula I, and optionally a pharmaceutically acceptable salt thereof:
Formula I,
wherein,
R is one selected from the group consisting of H and CH3;
n is an integer ranging from 3 to 4 when X is —CH2— and Ar is 1,4-phenyl, or n is an integer ranging from 1 to 4 when X is —CH2— and Ar is either 2?-fluoro-1,4-phenyl or 2,5-thienyl, or n is an integer ranging from 1 to 4 when X is one selected from the group consisting of O, S, —NH—, —NHCHO—, —NHCOCH3—, and —NHCOCF3— and Ar is one selected from the group consisting of (a) 1,4-phenyl, (b) 2?-fluoro-1,4-phenyl, and (c) 2,5-thienyl, wherein said cancer is selected from the group consisting of non-small cell lung cancer, pancreatic cancer, ovarian cancer, and colon cancer.

US Pat. No. 10,793,572

SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE DISEASES

THE PROVOST FELLOWS FOUND...

1. A compound of formula (I)or a pharmaceutically acceptable salt thereof,wherein:
R1 is selected from H and CH3;
R2 is selected from H, C4H9 alkyl, and C3H6-phenyl, said phenyl optionally substituted by OH or OCH3;
X is O or S; and
Y is N; and
R1 and R2 are not both H.

US Pat. No. 10,793,571

USES OF DIAZEPANE DERIVATIVES

Dana-Farber Cancer Instit...

1. A method of treating a leukemia in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of the formula:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,793,570

METHODS AND REAGENTS FOR RADIOLABELING

Memorial Sloan-Kettering ...

1. A method of administering a radiolabeled compound to a patient comprising administering to a patient in need thereof an amount of a compound of Formula IL:
or a pharmaceutically acceptable salt thereof,
wherein:
X is CH2—, —O—, or —S—;
Y1 and Y2 are independently —CR3a— or —N—;
Z1, Z2, and Z3 are independently —CH— or —N—;
R1 is hydrogen or halogen;
L is a straight or branched, C2-14 aliphatic group wherein one or more carbons are optionally and independently replaced by -Cy-, —NR—, —N(R)C(O)—, —C(O)N(R)—, —C(O)N(O)—, —N(R)SO2—, —SO2N(R)—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —S—, —SO—, or —SO2—,
each -Cy- is independently an optionally substituted 3-8 membered bivalent, saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered bivalent saturated, partially unsaturated, or aryl bicyclic ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
R2 is hydrogen or an optionally substituted group selected from the group consisting of C1-6 aliphatic, phenyl, 3- to 7-membered saturated or partially unsaturated monocyclic carbocyclyl, 3- to 7-membered saturated or partially unsaturated monocyclic heterocyclyl having 1-2 heteroatoms selected from oxygen, nitrogen, or sulfur, 5- to 6-membered heteroaryl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur, 7- to 10-membered saturated or partially unsaturated bicyclic carbocyclyl, 7- to 10-membered saturated or partially unsaturated bicyclic heterocyclyl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur, 7- to 10-membered bicyclic heteroaryl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur, or 8- to 10-membered bicyclic aryl;
each R3 is independently halogen, —NO2, —CN, —OR, —SR, —N(R)2, —C(O)R, —CO2R, —C(O)C(O)R, —C(O)CH2C(O)R, —S(O)R, —S(O)2R, —C(O)N(R)2, —SO2N(R)2, —OC(O)R, —N(R)C(O)R, —N(R)N(R)2, or optionally substituted C1-6 aliphatic or pyrrolyl; or
two R3 groups are taken together with their intervening atoms to form Ring A, wherein Ring A is a 3- to 7-membered partially unsaturated carbocyclyl, phenyl, a 5- to 6-membered partially unsaturated monocyclic heterocyclyl having 1-2 heteroatoms selected from oxygen, nitrogen, or sulfur, 5- to 6-membered heteroaryl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur, or 6-membered aryl;
R3a is R3 or hydrogen;
each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, phenyl, 3- to 7-membered saturated or partially unsaturated carbocyclyl, 3- to 7-membered saturated or partially unsaturated monocyclic heterocyclyl having 1-2 heteroatoms selected from oxygen, nitrogen, or sulfur, or 5- to 6-membered heteroaryl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur, or:
two R groups on the same nitrogen are taken together with their intervening atoms to form an optionally substituted ring selected from 3- to 7-membered saturated or partially unsaturated monocyclic heterocyclyl having 1-2 heteroatoms selected from oxygen, nitrogen, or sulfur, or 5- to 6-membered heteroaryl having 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur;
RL is a radiolabel;
with the proviso that compound IL is not

wherein the compound is administered intravenously, intramuscularly, intracutaneously, subcutaneously, intraduodenally, or intraperitoneally.

US Pat. No. 10,793,569

TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING HETEROATOM-LINKED AROMATIC MOIETIES, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR

BRISTOL-MYERS SQUIBB COMP...

1. A compound having a structure according to formula (Ib-12):

US Pat. No. 10,793,568

HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS

ARDELYX, INC., Fremont, ...

1. A compound of Formula (Ix):
or a salt thereof,
wherein:
L1 is —(CH2)p— and p is 1;
A is phenyl;
R1 and R2 are both a Cl;
R3 is cyclopropyl;
R4 is COOR6a; and
R6a is H.

US Pat. No. 10,793,567

BICYCLIC INHIBITORS OF HISTONE DEACETYLASE

Rodin Therapeutics, Inc.,...

1. A compound of the formula:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,793,566

BRUTON'S TYROSINE KINASE INHIBITORS

ZIBO BIOPOLAR CHANGSHENG ...

1. A compound of Formula (I) having the following structure:
wherein:
A is CH;
B is N;
C is CH;
D is C—R1;
R1 is Cl, F, OH, CN, —CHF2, —CH3, —OCH3—OCH2CH3, —OCH2CH2CH3, —OCH2CH2CH2CH3, —OCH(CH3)2, —OCH2CH2OH, —OCH2CH2NH2, —OCH2CH2N(CH3)2, or

R2 is

wherein X is O, OCRaRb, CRaRbO, S(O), S(O)2, CRaRb, NR(C?O), C?ONRc or a bond; and E is a hydrogen, an aryl or a heteroaryl substituted with one to three R5 substituents; or a 3-7 membered saturated or partially unsaturated carbocyclic ring, an 8-10 membered bicyclic saturated, partially unsaturated or aryl ring, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 7-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or —X-E is hydrogen, halogen, —ORa, —O(CH2)1-4Ra, —CN, —NO2;
R4 and R5 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, cyano, OCF3, OCF2H, C1-6 alkyl, optionally substituted with one to five fluorines, C3-6 cycloalkyl, optionally substituted with one to five fluorines, C1-4alkoxy, optionally substituted with one to five fluorines, C1-4 alkylthio, optionally substituted with one to five fluorines, C1-4 alkylsulfonyl, optionally substituted with one to five fluorines, carboxy, C1-4 alkyloxycarbonyl, and C1-4 alkylcarbonyl;
Ra and Rb are each independently hydrogen, fluorine, or C1-3 alkyl, optionally substituted with one to five fluorines;
Rc is hydrogen or C1-3 alkyl, optionally substituted with one to five fluorines;
R3 is a group having a double bond,
a stereoisomer thereof, a tautomer thereof, a solvate thereof, or a prodrug thereof.

US Pat. No. 10,793,564

AMINO ACID COMPOUNDS AND METHODS OF USE

PLIANT THERAPEUTICS, INC....

1. A compound of formula (II):
or a salt thereof, wherein:
R1 is C6-C14 aryl or 5- to 10-membered heteroaryl wherein the C6-C14 aryl and 5- to 10-membered heteroaryl are optionally substituted by R1a;
R2 is hydrogen; deuterium; C1-C6 alkyl optionally substituted by R2a; —OH; —O—C1-C6 alkyl optionally substituted by R2a; C3-C6 cycloalkyl optionally substituted by R2b: —O—C3-C6 cycloalkyl optionally substituted by R2b: 3- to 12-membered heterocyclyl optionally substituted by R2c; or —S(O)2R2d; with the proviso that any carbon atom bonded directly to a nitrogen atom is optionally substituted with an R2a moiety other than halogen;
each R1a is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C4-C8 cycloalkenyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, C6-C14 aryl, deuterium, halogen, —CN, —OR3, —SR3, —NR4R5, —NO2, —C?NH(OR3), —C(O)R3, —OC(O)R3, —C(O)OR3, —C(O)NR4R5, —NR3C(O)R4, —NR3C(O)OR4, —NR3C(O)NR4R5, —S(O)R3, —S(O)2R3, —NR3S(O)R4, —NR3S(O)2R4, —S(O)NR4R5, —S(O)2NR4R5, or —P(O)(OR4)(OR5), wherein each R1ais, where possible, independently optionally substituted by deuterium, halogen, oxo, —OR6, —NR6R7, —C(O)R6, —CN, —S(O)R6, —S(O)2R6, —P(O)(OR6)(OR7), C3-C8 cycloalkyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, C6-C14 aryl, or C1-C6 alkyl optionally substituted by deuterium, oxo, —OH or halogen;
each R2a, R2b, R2c, R2e, and R2f is independently oxo or R1a;
R2d is C1-C6 alkyl optionally substituted by R2e or C3-C5 cycloalkyl optionally substituted by R2f;
each R3 is independently hydrogen, deuterium, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl or 3- to 12-membered heterocyclyl, wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl and 3- to 12-membered heterocyclyl of R3 are independently optionally substituted by halogen, deuterium, oxo, —CN, —OR8, —NR8R9, —P(O)(OR8)(OR9), or C1-C6 alkyl optionally substituted by deuterium, halogen, —OH or oxo;
R4 and R5 are each independently hydrogen, deuterium, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5- to 6-membered heteroaryl or 3- to 6-membered heterocyclyl, wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5- to 6-membered heteroaryl and 3- to 6-membered heterocyclyl of R4 and R5 are independently optionally substituted by deuterium, halogen, oxo, —CN, —OR8, —NR8R9 or C1-C6 alkyl optionally substituted by deuterium, halogen, —OH or oxo;
or R4 and R5 are taken together with the atom to which they attached to form a 3- to 6-membered heterocyclyl optionally substituted by deuterium, halogen, oxo, —OR8, —NR8R9 or C1-C6 alkyl optionally substituted by deuterium, halogen, oxo or —OH;
R6 and R7 are each independently hydrogen, deuterium, C1-C6 alkyl optionally substituted by deuterium, halogen, or oxo, C2-C6 alkenyl optionally substituted by deuterium, halogen, or oxo, or C2-C6 alkynyl optionally substituted by deuterium, halogen, or oxo;
or R6 and R7 are taken together with the atom to which they attached to form a 3- to 6-membered heterocyclyl optionally substituted by deuterium, halogen, oxo or C1-C6 alkyl optionally substituted by deuterium, halogen, or oxo; and
R8 and R9 are each independently hydrogen, deuterium, C1-C6 alkyl optionally substituted by deuterium, halogen, or oxo, C2-C6 alkenyl optionally substituted by deuterium, halogen or oxo, or C2-C6 alkynyl optionally substituted by deuterium, halogen, or oxo;
or R8 and R9 are taken together with the atom to which they attached to form a 3-6 membered heterocyclyl optionally substituted by deuterium, halogen, oxo or C1-C6 alkyl optionally substituted by deuterium, oxo, or halogen.

US Pat. No. 10,793,563

GCN2 INHIBITORS AND USES THEREOF

MERCK PATENT GMBH, Darms...

1. A compound of one of formula XV-a, XV-a, or XV-c:
or a pharmaceutically acceptable salt thereof, wherein:
each of R1 is independently hydrogen, halogen, —CN, —NO2, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)NRS(O)2R, —C(O)N?S(O)R2, —NR2, —NRC(O)R, —NRC(O)NR2, —NRC(O)OR, —NRS(O)2R, —NRS(O)2NR2, —OR, —ON(R)SO2R, —P(O)R2, —SR, —S(O)R, —S(O)2R, —S(O)(NH)R, —S(O)2N(R)2, —S(NH2)2(O)OH, —N?S(O)R2, —CH3, —CH2OH, —CH2NHSO2CH3, —CD3, —CD2NRS(O)2R, or R; or
two R1 groups are optionally taken together to form ?O or ?NH; or
two R1 groups are optionally taken together to form a bivalent C2-4 alkylene chain;
each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or
two R groups are optionally taken together to form a bivalent C2-4 alkylene chain; or
two R groups are optionally taken together with their intervening atoms to form an optionally substituted 3-7 membered saturated or partially unsaturated monocyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen or sulfur;
m is 0, 1, 2, 3, 4 or 5.

US Pat. No. 10,793,562

N-PYRIDINYL ACETAMIDE DERIVATIVES AS WNT SIGNALLING PATHWAY INHIBITORS

Redx Pharma PLC, Maccles...

1. A pharmaceutical formulation comprising a compound of formula (VIa) and a pharmaceutically acceptable excipient:
wherein
het1 represents a substituted or unsubstituted 9 membered bicyclic heteroaryl group comprising a 5 membered ring, wherein the 5 membered ring comprises 1 or 2 nitrogen atoms, and a 6 membered ring, wherein the 6 membered ring comprises 1 or 2 nitrogen atoms, and when substituted the ring system is substituted with 1, 2, or 3 groups independently selected at each occurrence from the group consisting of halo, C1-4 alkyl, C1-4 haloalkyl, —ORA2, —NRA2RB2, —CN, SO2RA2, and C3-6 cycloalkyl;
het2 represents an aromatic, saturated or unsaturated 6 membered heterocyclic ring which is unsubstituted or substituted, and when substituted the ring is substituted with 1, 2 or 3 groups independently selected at each occurrence from the group consisting of halo, C1-4 alkyl, C1-4 haloalkyl, —ORA1, —NRA1RB1, —CN, —NO2, —NRA1C(O)RB1, —C(O)NRA1RB1, —NRA1SO2RB1, —SO2NRA1RB1, —SO2RA1, —C(O)RA1, —C(O)ORA1 and C3-6 cycloalkyl;
R3 is selected from the group consisting of H, C1-4 alkyl, C1-4 haloalkyl and C3-6 cycloalkyl;
R4 is independently selected at each occurrence from the group consisting of halo, C1-4 alkyl, C1-4 haloalkyl, —CN, —ORA4, —NRA4RB4, —SO2RA4, C3-6 cycloalkyl and C3-6 halocycloalkyl;
n is 0, 1 or 2; and
RA1, RB1, RA2, RB2, RA4 and RB4 are at each occurrence independently selected from the group consisting of H, C1-4 alkyl, C1-4 haloalkyl.

US Pat. No. 10,793,561

1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF

NUVATION BIO INC., New Y...

1. A compound of Formula (I):or a tautomer or isomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein:R1 is H or C1-C6 alkyl wherein the C1-C6 alkyl of R1 is optionally substituted with oxo or Ra;
R2 is H, Rb or oxo;
R4 is H, oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, —CN, —OR8, —SR8, —NO2, —C?NH(OR8), —C(O)R8, —OC(O)R8, —C(O)OR8, —C(O)NR9R10, —OC(O)NR9R10, —NR8C(O)OR9, —NR8C(O)NR9R10, —S(O)R8, —S(O)2R8, —NR8S(O)R9, —C(O)NR8S(O)R9, —NR8S(O)2R9, —C(O)NR8S(O)2R9, —S(O)NR9R10, —S(O)2NR9R10, —P(O)(OR9)(OR10), C3-C6 cycloalkyl, 3-12-membered heterocyclyl, 5- to 10-membered heteroaryl, C6-C14 aryl, —(C1-C3 alkylene)CN, —(C1-C3 alkylene)OR8, —(C1-C3 alkylene)SR8, —(C1-C3 alkylene)NR9R10, —(C1-C3 alkylene)CF3, —(C1-C3 alkylene)NO2, —C?NH(OR8), —(C1-C3 alkylene)C(O)R8, —(C1-C3 alkylene)OC(O)R8, —(C1-C3 alkylene)C(O)OR8, —(C1-C3 alkylene)C(O)NR9R10, —(C1-C3 alkylene)OC(O)NR9R10, —(C1-C3 alkylene)NR8C(O)R9, —(C1-C3 alkylene)NR8C(O)OR9, —(C1-C3 alkylene)NR8C(O)NR9R10, —(C1-C3 alkylene)S(O)R8, —(C1-C3 alkylene)S(O)2R8, —(C1-C3 alkylene)NR8S(O)R9, —C(O)(C1-C3 alkylene)NR8S(O)R9, —(C1-C3 alkylene)NR8S(O)2R9, —(C1-C3 alkylene)C(O)NR8S(O)2R9, —(C1-C3 alkylene)S(O)NR9R10, —(C1-C3 alkylene)S(O)2NR9R10, —(C1-C3 alkylene)P(O)(OR9)(OR10), —(C1-C3 alkylene)(C3-C6 cycloalkyl), —(C1-C3 alkylene)(3-12-membered heterocyclyl), —(C1-C3 alkylene)(5-10-membered heteroaryl) or -(C1-C3 alkylene)(C6-C14 aryl), each of which is independently optionally substituted by halogen, oxo, —OR11, —NR11R12, —C(O)R11, —CN, —S(O)R11, —S(O)2R11, —P(O)(OR11)(OR12), —(C1-C3 alkylene)OR11, —(C1-C3 alkylene)NR11R12, —(C1-C3 alkylene)C(O)R11, —(C1-C3 alkylene)S(O)R11, —(C1-C3 alkylene)S(O)2R11, —(C1-C3 alkylene)P(O)(OR11)(OR12), C3-C8 cycloalkyl, or C1-C6 alkyl optionally substituted by oxo, —OH or halogen;
R3 and R5 are each independently H or Rc;
each Ra, Rb, and Rc is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, —CN, —OR8, —SR8, —NR9R10, —NO2, —C?NH(OR8), —C(O)R8, —OC(O)R8, —C(O)OR8, —C(O)NR9R10, —OC(O)NR9R10, —NR8C(O)R9, —NR8C(O)OR9, —NR8C(O)NR9R10, —S(O)R8, —S(O)2R8, —NR8S(O)R9, —C(O)NR8S(O)R9, —NR8S(O)2R9, —C(O)NR8S(O)2R9, —S(O)NR9R10, —S(O)2NR9R10, —P(O)(OR9)(OR10), C3-C6 cycloalkyl, 3-12-membered heterocyclyl, 5- to 10-membered heteroaryl, C6-C14 aryl, —(C1-C3 alkylene)CN, —(C1-C3 alkylene)OR8, —(C1-C3 alkylene)SR8, —(C1-C3 alkylene)NR9R10, —(C1-C3 alkylene)CF3, —(C1-C3 alkylene)NO2, —C?NH(OR8), —(C1-C3 alkylene)C(O)R8, —(C1-C3 alkylene)OC(O)R8, —(C1-C3 alkylene)C(O)OR8, —(C1-C3 alkylene)C(O)NR9R10, —(C1-C3 alkylene)OC(O)NR9R10, —(C1-C3 alkylene)NR8C(O)R9, —(C1-C3 alkylene)NR8C(O)OR9, —(C1-C3 alkylene)NR8C(O)NR9R10, —(C1-C3 alkylene)S(O)R8, —(C1-C3 alkylene)S(O)2R8, —(C1-C3 alkylene)NR8S(O)R9, —C(O)(C1-C3 alkylene)NR8S(O)R9, —(C1-C3 alkylene)NR8S(O)2R9, —(C1-C3 alkylene)C(O)NR8S(O)2R9, —(C1-C3 alkylene)S(O)NR9R10, —(C1-C3 alkylene)S(O)2NR9R10, —(C1-C3 alkylene)P(O)(OR9)(OR10), —(C1-C3 alkylene)(C3-C6 cycloalkyl), —(C1-C3 alkylene)(3-12-membered heterocyclyl), —(C1-C3 alkylene)(5-10-membered heteroaryl) or -(C1-C3 alkylene)(C6-C14 aryl), wherein each Ra, Rb, and Rc is independently optionally substituted by halogen, oxo, —OR11, —NR11R12, —C(O)R11, —CN, —S(O)R11, —S(O)2R11, —P(O)(OR11)(OR12), —(C1-C3 alkylene)OR11, —(C1-C3 alkylene)NR11R12, —(C1-C3 alkylene)C(O)R11, —(C1-C3 alkylene)S(O)R11, —(C1-C3 alkylene)S(O)2R11, —(C1-C3 alkylene)P(O)(OR11)(OR12), C3-C8 cycloalkyl, or C1-C6 alkyl optionally substituted by oxo, —OH or halogen;
wherein when R1 is C1-C6 alkyl, R4 is other than —NR9R10 and R3 is other than —C(O)R8;
------ is a single bond or a double bond, wherein when ------ is a double bond, R2 is oxo;
is a single bond or a double bond, wherein when is a double bond, R4 is oxo;
one of ------ and is a double bond and the other is a single bond;
A is C6-C12 aryl, 5- to 10-membered heteroaryl, 9- to 10-membered carbocycle, or 9- to 10-membered heterocycle, wherein the C6-C12 aryl, 5- to 10-membered heteroaryl or 9- to 10-membered carbocycle, or 9- to 10-membered heterocycle of A is optionally further substituted with R6;
B is phenyl, 5- to 6-membered heteroaryl, 5- to 6-membered carbocycle, 5- to 6-membered heterocycle, or 9- to 10-membered heteroaryl, wherein the phenyl, 5- to 6-membered heteroaryl, 5- to 6-membered carbocycle, 5- to 6-membered heterocycle, or 9- to 10-membered heteroaryl of B is optionally further substituted with R7;
wherein when B is 5- to 6-membered heterocycle, A is other than phenyl optionally further substituted with R6 or pyridyl optionally further substituted with R6;
each R6 and R7 is independently oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, —CN, —OR8, —SR8, —NR9R10, —NO2, —C?NH(OR8), —C(O)R8, —OC(O)R8, —C(O)OR8, —C(O)NR9R10, —OC(O)NR9R10, —NR8C(O)R9, —NR8C(O)OR9, —NR8C(O)NR9R10, —S(O)R8, —S(O)2R8, —NR8S(O)R9, —C(O)NR8S(O)R9, —NR8S(O)2R9, —C(O)NR8S(O)2R9, —S(O)NR9R10, —S(O)2NR9R10, —P(O)(OR9)(OR10), C3-C6 cycloalkyl, 3-12-membered heterocyclyl, 5- to 10-membered heteroaryl, C6-C14 aryl, —(C1-C3 alkylene)CN, —(C1-C3 alkylene)OR8, —(C1-C3 alkylene)SR8, —(C1-C3 alkylene)NR9R10, —(C1-C3 alkylene)CF3, —(C1-C3 alkylene)NO2, —C?NH(OR8), —(C1-C3 alkylene)C(O)R8, —(C1-C3 alkylene)OC(O)R8, —(C1-C3 alkylene)C(O)OR8, —(C1-C3 alkylene)C(O)NR9R10, —(C1-C3 alkylene)OC(O)NR9R10, —(C1-C3 alkylene)NR8C(O)R9, —(C1-C3 alkylene)NR8C(O)OR9, —(C1-C3 alkylene)NR8C(O)NR9R10, —(C1-C3 alkylene)S(O)R8, —(C1-C3 alkylene)S(O)2R8, —(C1-C3 alkylene)NR8S(O)R9, —C(O)(C1-C3 alkylene)NR8S(O)R9, —(C1-C3 alkylene)NR8S(O)2R9, —(C1-C3 alkylene)C(O)NR8S(O)2R9, —(C1-C3 alkylene)S(O)NR9R10, —(C1-C3 alkylene)S(O)2NR9R10, —(C1-C3 alkylene)P(O)(OR9)(OR10), —(C1-C3 alkylene)(C3-C6 cycloalkyl), —(C1-C3 alkylene)(3-12-membered heterocyclyl), —(C1-C3 alkylene)(5-10-membered heteroaryl) or -(C1-C3 alkylene)(C6-C14 aryl), wherein each R6 and R7 is independently optionally substituted by halogen, oxo, —OR11, —NR11R12, —C(O)R11, —CN, —S(O)R11, —S(O)2R11, —P(O)(OR11)(OR12), —(C1-C3 alkylene)OR11, —(C1-C3 alkylene)NR11R12, —(C1-C3 alkylene)C(O)R11, —(C1-C3 alkylene)S(O)R11, —(C1-C3 alkylene)S(O)2R11, —(C1-C3 alkylene)P(O)(OR11)(OR12), C3-C8 cycloalkyl, or C1-C6 alkyl optionally substituted by oxo, —OH or halogen;
R8 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5-6-membered heteroaryl, 3-6-membered heterocyclyl, —(C1-C3 alkylene)(C3-C6 cycloalkyl), —(C1-C3 alkylene)(C6-C14 aryl), —(C1-C3 alkylene)(5-6-membered heteroaryl), or -(C1-C3 alkylene)(3-6-membered heterocyclyl), wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5-6-membered heteroaryl, 3-6-membered heterocyclyl, —(C1-C3 alkylene)(C3-C6 cycloalkyl), —(C1-C3 alkylene)(C6-C14 aryl), —(C1-C3 alkylene)(5-6-membered heteroaryl), and -(C1-C3 alkylene)(3-6-membered heterocyclyl) are independently optionally substituted by halogen, oxo, —CN, —OR13, —NR13R14, —P(O)(OR13)(OR14), phenyl optionally substituted by halogen, or C1-C6 alkyl optionally substituted by halogen, —OH or oxo;
R9 and R10 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5-6-membered heteroaryl, 3-6 membered heterocyclyl, —(C1-C3 alkylene)NR11R12, C3 alkylene)(C3-C6 cycloalkyl), —(C1-C3 alkylene)(3-6-membered heterocyclyl), —(C1-C3 alkylene)(5-6-membered heteroaryl) or -(C1-C3 alkylene)(C6 aryl), wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5-6-membered heteroaryl, 3-6 membered heterocyclyl, —(C1-C3 alkylene)(C3-C6 cycloalkyl), —(C1-C3 alkylene)(3-6-membered heterocyclyl), —(C1-C3 alkylene)(5-6-membered heteroaryl) and —(C1-C3 alkylene)(C6 aryl) are independently optionally substituted by halogen, oxo, —CN, —OR13, —NR13R14 or C1-C6 alkyl optionally substituted by halogen, —OH or oxo;
or R9 and R10 are taken together with the atom to which they attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo, —OR13, —NR3R14 or C1-C6 alkyl optionally substituted by halogen, oxo or —OH;
R11 and R12 are each independently hydrogen, C1-C6 alkyl optionally substituted by halogen or oxo, C2-C6 alkenyl optionally substituted by halogen or oxo, or C2-C6 alkynyl optionally substituted by halogen or oxo;
or R11 and R12 are taken together with the atom to which they attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo or C1-C6 alkyl optionally substituted by halogen or oxo; and
R13 and R14 are each independently hydrogen, C1-C6 alkyl optionally substituted by halogen or oxo, C2-C6 alkenyl optionally substituted by halogen or oxo, or C2-C6 alkynyl optionally substituted by halogen or oxo;
or R13 and R14 are taken together with the atom to which they attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo or C1-C6 alkyl optionally substituted by oxo or halogen.

US Pat. No. 10,793,560

N-PYRIDINYL ACETAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALING PATHWAY

RedX Pharma PLC, Maccles...

1. A pharmaceutical formulation comprising a compound of formula (III):whereinX1 and X2 are selected from CR6 and N, provided that one of X1 and X2 is CR6 and the other is N;
het2 is a 6 membered heteroaryl ring containing 1, 2 or 3 N heteroatoms which may be unsubstituted or substituted, and when substituted the ring is substituted with 1, 2 or 3 groups independently selected at each occurrence from the group consisting of halo, C1-4 alkyl, C1-4 haloalkyl, —ORA1, —NRA1RB1, —CN, and NRA1C(O)RB1;
het3 is a 6 membered heteroaryl ring containing 1, 2 or 3 N heteroatoms which may be unsubstituted or substituted, and when substituted the ring is substituted with 1, 2 or 3 groups independently selected at each occurrence from the group consisting of halo, C1-4 alkyl, C1-4 haloalkyl, —ORA1, —NRA1RB1, —CN, and NRA1C(O)RB1;
R1 and R2 are each H;
R3 is selected from the group consisting of H, C1-4 alkyl, C1-4 haloalkyl, and C3-6 cycloalkyl;
R4 is independently selected at each occurrence from the group consisting of halo, C1-4 alkyl, C1-4 haloalkyl, —CN, —ORA4, —NRA4RB4, —SO2RA4, C3-6 cycloalkyl and C3-6 halocycloalkyl;
R5 and R6 are, at each occurrence, independently selected from the group consisting of H, halo, C1-4 alkyl, C1-4 haloalkyl, —ORA2, —NRA2RB2, —CN, —SO2RA2, and C3-6 cycloalkyl;
m is 1;
n is selected from 0, 1 or 2; and
RA1, RB1, RA2, RB2, RA4 and RB4 are at each occurrence independently selected from the group consisting of H, C1-4 alkyl, and C1-4 haloalkyl; and
a pharmaceutically acceptable excipient.

US Pat. No. 10,793,559

CHEMICAL COMPOUNDS

GlaxoSmithKline Intellect...

1. A method of treating a disorder mediated by inappropriate PI3-kinase activity comprising administering an amount of a compound of formula (I):
wherein
R1 is C1-6alkoxy or —N(C1-6alkyl)2,
R2 is hydrogen or C1-6alkyl optionally substituted by —C(O)OC1-6alkyl or —OC(O)C1-6alkyl,
R3, R4, R5 and R6 are each independently selected from hydrogen and halogen;
R7 and R8 are each independently C1-6alkyl, or
R7 and R8, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 5- or 6-membered heterocyclyl optionally contains a further nitrogen atom and is optionally substituted by C3-6cycloalkyl, 4- to 6-membered heterocyclyl containing one or two heteroatoms independently selected from oxygen and nitrogen, or C1-6alkyl wherein the C1-6alkyl is optionally substituted by hydroxy or C1-6alkoxy, or
R7 and R8, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 5- or 6-membered heterocyclyl contains an oxygen atom and is optionally substituted by one or two substituents independently selected from C1-6alkyl;
or a pharmaceutically acceptable salt thereof, to a patient in need thereof, by inhibiting PI3-kinase activity and wherein said disorder mediated by inappropriate PI3-kinase activity is selected from the group consisting of asthma and COPD.

US Pat. No. 10,793,558

QUINOLINE OXADIAZOLES AS CYTOPROTECTIVE AGENTS

1. A compound of Formula I:or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; wherein:R2 is methyl;
R3, R4, R5, R6, and R7 are each independently (a) hydrogen, cyano, or halo or (b) C1-6 alkyl with the proviso that R3 and R7 are not concurrently Cl; and
R1 is optionally substituted phenyl, thiophenyl, or furanyl with the proviso that R1 is not 2-methoxy-phenyl or 2-butoxy-phenyl.

US Pat. No. 10,793,557

STING AGONIST COMPOUNDS

1. A compound according to general formula (I):or a pharmaceutically acceptable salt thereof, whereineach A-R1 is independently selected from the group consisting of C—R1 and N;
each R1 is independently selected from the group consisting of H, halogen, OR6, N(R6)2, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyl substituted by OR6, C1-C6 alkyl substituted by N(R6)2, COOR6, and C(O)N(R6)2;
each R2 is independently selected from the group consisting of H, halogen, CN, OR6, N(R6)2, COOR6, C(O)N(R6)2, SO2R6, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyl substituted by OR6, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkenyl substituted by OR6, C2-C6 alkynyl, C2-C6 haloalkynyl, C2-C6 alkynyl substituted by OR6, C3-C6 cycloalkyl, and a 3- to 6-membered heterocyclic ring including 1 to 2 ring members selected from the group consisting of O, S, and N(R6);
R3 and R4 are independently selected from the group consisting of O—(C1-C4 alkylene or haloalkylene), C1-C5 alkylene or haloalkylene, and N(R6)—(C1-C4 alkylene or haloalkylene);
optionally R4 may be taken together with an adjacent C—R1 and the atom to which they are attached to form fused ring E, which is selected from phenyl or a 5- or 6-membered heterocyclic ring including 1 to 2 ring members selected from the group consisting of O, S, N, and N(R6) wherein the bond to R3 from said ring E is from an atom on said ring E with an open valence for substitution and wherein said phenyl or heterocyclic ring is optionally substituted with one or more members of the group consisting of halogen, C1-C3 alkyl, and C1-C3 haloalkyl;
each R6 is independently selected from the group consisting of H, C1-C6 alkyl, and C1-C6 haloalkyl;
each X1 is independently selected from the group consisting of C?O, —CH2—, —CHF—, and —CF2—;
each X2 is independently selected from (C(R8)2)(1-3), wherein each R8 is independently selected from the group consisting of H, halogen, C1-C6 alkyl, CN, OR6, N(R6)2, C1-C6 haloalkyl, C3-C6 cycloalkyl, C1-C6 alkyl substituted by OR6, and C1-C6 alkyl substituted by N(R6)2;
optionally 2 R8 on different carbon atoms may be taken together, along with the atoms to which they are attached, to form a 3- to 6-membered fused ring; and
optionally 2 R8 on a single carbon atom may be taken together, along with the atom to which they are attached, to form a 3- to 6-membered spirocycle;
each X3 is independently selected from the group consisting of COOR6, C(O)SR6, C(S)OR6,
SO2R6, C(O)N(R9)2, and CN; andeach R9 is independently selected from the group consisting of H, COOR6, and SO2R6.

US Pat. No. 10,793,556

8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES

GRUENENTHAL GMBH, Aachen...

1. A compound according to general formula (I)
wherein
R1 and R2 independently of one another mean
—H;
—C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —OH, —OCH3, —CN and —CO2CH3;
a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —OH, —OCH3, —CN and —CO2CH3; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted; or
a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —OH, —OCH3, —CN and —CO2CH3; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted;
or
R1 and R2 together with the nitrogen atom to which they are attached form a ring and mean —(CH2)3-6—; —(CH2)2—O—(CH2)2—; or —(CH2)2—NRA—(CH2)2—, wherein RA means —H or —C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br and —I;
R3 means
C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;
a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;
a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;
a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or
a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;
R4 means
—H;
—C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said —C1-C6-alkyl is optionally connected through —C(?O)—, —C(?O)O—, or —S(?O)2—;
a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C(?O)—, —C(?O)O—, —C(?O)O—CH2—, or —S(?O)2—;
a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C(?O)—, —C(?O)O—, —C(?O)O—CH2—, or —S(?O)2—;
a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 6-14-membered aryl moiety is optionally connected through —C(?O)—, —C(?O)O—, —C(?O)O—CH2—, or —S(?O)2—; or
a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 5-14-membered heteroaryl moiety is optionally connected through —C(?O)—, —C(?O)O—, —C(?O)O—CH2—, or —S(?O)2—;
R5 means
—H;
—C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;
a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;
a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or
a moiety according to general formula (X);

R11, R12, R13, R14, R15, R16, R17, R18, R19, and R20 independently of one another mean —H, —F, —Cl, —Br, —I, —OH, or —C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;
wherein “mono- or polysubstituted” means that one or more hydrogen atoms are replaced by a substituent independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —R21, —C(?O)R21, —C(?O)OR21, —C(?O)NR21R22, —O—(CH2CH2—O)1-30—H, —O—(CH2CH2—O)1-30—CH3, ?O, —OR21, —OC(?O)R21, —OC(?O)OR21, —OC(?O)NR21R22, —NO2, —NR21R22, —NR21—(CH2)1-6—C(?O)R22, —NR21—(CH2)1-6—C(?O)OR22, —NR23—(CH2)1-6—C(?O)NR21R22, —NR21C(?O)R22, —NR21C(?O)—OR22, —NR23C(?O)NR21R22, —NR21S(?O)2R22, —SR21, —S(?O)R21, —S(?O)2R21, —S(?O)2OR21, and —S(?O)2NR21R22;
wherein
R21, R22 and R23 independently of one another mean
—H;
—C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, —NH2, and —O—C1-C6-alkyl;
a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, —NH2, —C1-C6-alkyl and —O—C1-C6-alkyl;
a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, —NH2, —C1-C6-alkyl and —O—C1-C6-alkyl;
a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, —NH2, —C1-C6-alkyl and —O—C1-C6-alkyl;
a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through —C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, —NH2, —C1-C6-alkyl and —O—C1-C6-alkyl;
or R21 and R22 within —C(?O)NR21R22, —OC(?O)NR21R22, —NR21R22, —NR23—(CH2)1-6—C(?O)NR21R22, —NR23C(?O)NR21R22, or —S(?O)2NR21R22 together with the nitrogen atom to which they are attached form a ring and mean —(CH2)3-6—; —(CH2)2—O—(CH2)2—; or —(CH2)2—NRB—(CH2)2—, wherein RB means —H or —C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br and —I;
or a physiologically acceptable salt thereof.

US Pat. No. 10,793,555

OXIME ESTER PHOTOINITIATORS

BASF SE, (DE)

1. Compounds of formula (I)
whereinX isA is O, S, NR5 or CR16R17;R1 is hydrogen, or C1-C20alkyl which is unsubstituted, or substituted by one or more substituents selected from the group consisting ofhalogen, OR3, SR4, NR5R6, CN, (CO)OR3, (CO)NR5R6, C3-C8cycloalkyl, C3-C8cycloalkyl which is interrupted by one or more O, S, CO or NR5, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl and C3-C20heteroarylcarbonyl, of which C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl orC3-C20heteroarylcarbonyl is unsubstituted, or substituted by one or more halogen, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, C1-C4haloalkyl, CN, NO2, OR3, SR4 or NR5R6; orR1 is C2-C20alkyl interrupted by one or more O, S, NR5, CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted or substituted by one or more C3-C8cycloalkyl, OH, SH, O(CO)R1a, (CO)OR3, (CO)NR5R6, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, C1-C8alkyl, OR3, SR4 or NR5R6;R1 is C2-C12alkenyl or C3-C20cycloalkyl, each of which is uninterrupted, or interrupted by one or more O, S, CO, NR5 or COOR3;R1a is selected from hydrogen, or C1-C20alkyl which is unsubstituted, or substituted by one or more substituents selected from the group consisting of halogen, OR3a, SR4a, NR5aR6a, CN, (CO)OR3a, (CO)NR5aR6a, C3-C8cycloalkyl which is uninterrupted or interrupted by one or more O, S, CO or NR5a, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl andC3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, C1-C4haloalkyl, CN, NO2, OR3a, SR4a or NR5aR6a;R1a is C2-C20alkyl interrupted by one or more O, S, NR5a, CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted or substituted by one or more C3-C8cycloalkyl, OH, SH, O(CO)-(C1-C8alkyl), (CO)OR3a, (CO)NR5aR6a, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl orC3-C20heteroarylcarbonyl is unsubstituted, or substituted by one or more halogen, C1-C8alkyl, OR3a, SR4a or NR5aR6a;R1a is C2-C12alkenyl or C3-C20cycloalkyl, each of which is uninterrupted or interrupted by one or more O, S, CO, NR5a or COOR3a;
R1a is C6-C20aryl or C3-C20heteroaryl, which C6-C20aryl or C3-C20heteroaryl is unsubstituted or substituted by one or more halogen, C1-C20alkyl, C1-C4haloalkyl, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, CN, NO2, OR3a, SR4a, NR5aR6a, COOR3a, (CO)-(C1-C8alkyl), benzoyl or SO2-(C1-C4haloalkyl);
R1a is C1-C20alkoxy, which is unsubstituted or substituted by one or more C1-C10alkyl, C1-C4haloalkyl, halogen, phenyl, C1-C20alkylphenyl or C1-C8alkoxyphenyl;
R1a is C2-C20alkoxy, which is interrupted by one or more O, S, NR5a, CO, SO or SO2; or R1a is C6-C20aryloxy or C3-C20heteroaryloxy, which C6-C20aryloxy or C3-C20heteroaryloxy is unsubstituted, or substituted by one or more halogen, C1-C20alkyl, C1-C4haloalkyl, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, CN, NO2, OR3a, SR4a, NR5aR6a, COOR3a, (CO)(C1-C8alkyl), SO2-(C1-C4haloalkyl), benzoyl, or
which benzoyl oris unsubstituted, or substituted byR2 is unsubstituted, branched C5alkyl;R3 is selected from hydrogen, (CO)R1a, (CO)OR3a, CONR5R6, C1-C20alkyl, which is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, OR3a, SR4a, NR5aR6a, CN, (CO)OR3a, (CO)NR5aR6a, PO(OR1a)2, S(O)mR1a, C3-C8cycloalkyl which is uninterrupted or interrupted by one or more O, S, CO or NR5a, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl and C3-C20heteroarylcarbonyl, which C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted, or substituted by one or more halogen, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, C1-C4haloalkyl, CN, NO2, OR3a, SR4a, NR5aR6a, PO(OR1a)2 or S(O)mR1a;R3 is C2-C20alkyl interrupted by one or more O, S, NR5a, CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted or substituted by one or more C3-C8cycloalkyl, OH, SH, O(CO)R1a, (CO)OR3a, (CO)NR5aR6a, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl orC3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, C1-C8alkyl, OR3a, SR4a or NR5aR6a;R3 is C2-C12alkenyl or C3-C20cycloalkyl, which C2-C12alkenyl or C3-C20cycloalkyl is uninterrupted, or interrupted by one or more O, S, CO, NR5a or COOR3a;
R3 is C6-C20aryl or C3-C20heteroaryl, which C6-C20aryl or C3-C20heteroaryl is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, CN, NO2, OR3a, SR4a, NR5aR6a, COOR3a, (CO)R1a (CO)NR5aR6a, PO(OR1a)2, S(O)mR1a,
C1-C20alkyl which is unsubstituted or substituted by one or more halogen, COOR3a, CONR5aR6a, phenyl, C3-C8cycloalkyl, C3-C20heteroaryl, OR3a, SR4a or NR5aR6a, C2-C20alkyl which is interrupted by one or more O, S or NR5a; phenyl, naphthyl, benzoyl and naphthoyl, which phenyl, naphthyl, benzoyl or naphthoyl is unsubstituted, or substituted by one or more OR3a, SR4a or NR5aR6a;R3 together with one of the carbon atoms of R2 or M forms a 5- or 6-membered saturated or unsaturated ring which is uninterrupted, or interrupted by O, S or NR5a, and which 5- or 6-membered saturated or unsaturated ring is unsubstituted, or substituted by one or moreC1-C20alkyl, OR3a, SR4a, NR5aR6a, (CO)R1a, NO2, halogen, C1-C4-haloalkyl, CN, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl,or C3-C20cyclalkyl which is uninterrupted or interrupted by one or more O, S, CO or NR5a; orR3 is R3a, and R3a is selected from hydrogen, (CO)O(C1-C8alkyl) or CON(C1-C8alkyl)2;R3a is C1-C20alkyl which is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, OH, SH, CN, C3-C8alkenoxy, OCH2CH2CN, OCH2CH2(CO)O(C1-C8alkyl), O(CO)(C1-C8alkyl), O(CO)(C2-C4)alkenyl, O(CO)phenyl, (CO)OH, (CO)O(C1-C8alkyl), C3-C8cycloalkyl, SO2(C1-C4haloalkyl), O(C1-C4haloalkyl), phenyl, C1-C8alkylphenyl, C1-C8alkoxyphenyl and C3-C8cycloalkyl which is interrupted by one or more O;
R3a is C2-C20alkyl interrupted by one or more O, S, N(C1-C8alkyl), CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted or substituted by one or more C3-C8cycloalkyl, OH, SH, O(CO)(C1-C8alkyl), (CO)O(C1-C8alkyl), (CO)N(C1-C8alkyl)2, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, C1-C8alkyl, C1-C8alkoxy, C1-C8alkylsulfanyl or N(C1-C8alkyl)2;
R3a is C2-C12alkenyl or C3-C8cycloalkyl, which C2-C12alkenyl or C3-C8cycloalkyl is uninterrupted or interrupted by one or more O, S, CO, N(C1-C8alkyl) or COO(C1-C8alkyl);or R3a is C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, which C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, CN, NO2, OH, C1-C8alkyl, C1-C4haloalkyl, C1-C8alkoxy, phenyl-C1-C3alkyloxy, phenoxy, C1-C8alkylsulfanyl, phenylsulfanyl, N(C1-C8alkyl)2, diphenylamino, (CO)O(C1-C8alkyl), (CO)C1-C8alkyl or (CO)N(C1-C8)2, phenyl or benzoyl; orR3a is C1-C20alkanoyl or C3-C12alkenoyl, which C1-C20alkanoyl or C3-C12alkenoyl is unsubstituted or substituted by one or more halogen, phenyl, C1-C8alkylphenyl, C1-C8alkoxyphenyl, OH, C1-C8alkoxy, phenoxy, C1-C8alkylsulfanyl, phenylsulfanyl, N(C1-C8alkyl)2 or diphenylamino;R4 is selected from hydrogen, C1-C20alkyl which is unsubstituted, or substituted by one or more substituents selected from the group consisting of halogen, OR3a, SR4a, NR5aR6a, CN, (CO)OR3a, (CO)NR5aR6a, PO(OR1a)2, S(O)mR1a, C3-C8cycloalkyl which is uninterrupted or interrupted by one or more O, S, CO or NR5a, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl andC3-C20heteroarylcarbonyl, which C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted, or substituted by one or more halogen, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, C1-C4haloalkyl, CN, NO2, OR3a, SR4a, NR5aR6a, PO(OR1a)2 or S(O)mR1a;R4 is C2-C20alkyl interrupted by one or more O, S, NR5a, CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted, or substituted by one or more C3-C8cycloalkyl, OH, SH, O(CO)R1a, (CO)OR3a, (CO)NR5aR6a, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl orC3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted, or substituted by one or more halogen, C1-C8alkyl, OR3a, SR4a or NR5aR6a;R4 is C2-C12alkenyl or C3-C20cycloalkyl, which C2-C12alkenyl or C3-C20cycloalkyl is uninterrupted or interrupted by one or more O, S, CO, NR5a or COOR3a;
R4 is C6-C20aryl or C3-C20heteroaryl, which C6-C20aryl or C3-C20heteroaryl is unsubstituted, or substituted by one or more substituents selected from the group consisting of halogen, CN, NO2, OR3a, SR4a, NR5aR6a, COOR3a, (CO)R1a (CO)NR5aR6a, PO(OR1a)2, S(O)mR1a,
C1-C20alkyl which is unsubstituted, or substituted by one or more halogen, COOR3a, CONR5aR6a, phenyl, C3-C8cycloalkyl, C3-C20heteroaryl, OR3a, SR4a or NR5aR6a, C2-C20alkyl which is interrupted by one or more O, S or NR5a,phenyl, naphthyl, benzoyl and naphthoyl, which phenyl, naphthyl, benzoyl or naphthoyl is unsubstituted, or substituted by OR3a, SR4a or NR5aR6a;R4 together with one of the carbon atoms of R2 or M forms a 5- or 6-membered saturated or unsaturated ring which is uninterrupted, or interrupted by O, S or NR5a, and which 5- or 6-membered saturated or unsaturated ring is unsubstituted or substituted by one or moreC1-C20alkyl, OR3a, SR4a, NR5aR6a, (CO)R1a, NO2, halogen, C1-C4-haloalkyl, CN, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl,or C3-C20cyclalkyl which is uninterrupted, or interrupted by one or more O, S, CO or NR5a; orR4 is R4a, and R4a is selected from hydrogen, C1-C20alkyl which is unsubstituted, or substituted by one or more substituents selected from the group consisting of halogen, OH, SH, CN, C3-C8alkenoxy, OCH2CH2CN, OCH2CH2(CO)O(C1-C8alkyl), O(CO)(C1-C8alkyl), O(CO)(C2-C4)alkenyl, O(CO)phenyl, (CO)OH, (CO)O(C1-C8alkyl), C3-C8cycloalkyl, SO2(C1-C4haloalkyl), O(C1-C4haloalkyl), phenyl, C1-C8alkylphenyl, C1-C8alkoxyphenyl and C3-C8cycloalkyl which is interrupted by one or more O;R4a is C2-C20alkyl interrupted by one or more O, S, N(C1-C8alkyl), CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted or substituted by one or more C3-C8cycloalkyl, OH, SH, O(CO)(C1-C8alkyl), (CO)O(C1-C8alkyl), (CO)N(C1-C8alkyl)2, C6-C20aryl,C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted, or substituted by one or more halogen, C1-C8alkyl, C1-C8alkoxy, C1-C8alkylsulfanyl or N(C1-C8alkyl)2;R4a is C2-C12alkenyl or C3-C8cycloalkyl, which C2-C12alkenyl or C3-C8cycloalkyl is uninterrupted, or interrupted by one or more O, S, CO, N(C1-C8alkyl) or COO(C1-C8alkyl);
R4a is C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, whichC6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, CN, NO2, OH, C1-C8alkyl, C1-C4haloalkyl, C1-C8alkoxy, phenyl-C1-C3alkyloxy, phenoxy, C1-C8alkylsulfanyl, phenylsulfanyl, N(C1-C8alkyl)2, diphenylamino, (CO)O(C1-C8alkyl), (CO)C1-C8alkyl, (CO)N(C1-C8)2, phenyl or benzoyl; orR4a is C1-C20alkanoyl or C3-C12alkenoyl, which C1-C20alkanoyl or C3-C12alkenoyl is unsubstituted, or substituted by one or more halogen, phenyl, C1-C8alkylphenyl, C1-C8alkoxyphenyl, OH, C1-C8alkoxy, phenoxy, C1-C8alkylsulfanyl, phenylsulfanyl, N(C1-C8alkyl)2 or diphenylamino;R5 and R6 independently of each other are hydrogen, S(O)mR1a, O(CO)R1a, (CO)R1a or CONR5aR6a;R5 and R6 independently of each other are C1-C20alkyl which is unsubstituted, or substituted by one or more substituents selected from the group consisting of halogen, OR3a, SR4a, NR5aR6a, CN, (CO)OR3a, (CO)NR5aR6a, PO(OR1a)2, S(O)mR1a, C3-C8cycloalkyl, which is uninterrupted, or interrupted by one or more O, S, CO or NR5a, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl and C3-C20heteroarylcarbonyl, of which C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted, or substituted by one or more halogen, phenyl,C1-C20alkylphenyl, C1-C8alkoxyphenyl, C1-C4haloalkyl, CN, NO2, OR3a, SR4a, NR5aR6a, PO(OR1a)2 or S(O)mR1a;R5 and R6 independently of each other are C2-C20alkyl interrupted by one or more O, S, NR5a, CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted, or substituted by one or more C3-C8cycloalkyl, OH, SH, O(CO)R1a, (CO)OR3a, (CO)NR5aR6a, C6-C20aryl,C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted, or substituted by one or more halogen, C1-C8alkyl, OR3a, SR4a or NR5aR6a;R5 and R6 independently of each other are C2-C12alkenyl or C3-C20cycloalkyl, whichC2-C12alkenyl or C3-C20cycloalkyl is uninterrupted, or interrupted by one or more O, S, CO, NR5a or COOR3a;R5 and R6 independently of each other are C6-C20aryl or C3-C20heteroaryl, which C6-C20aryl or C3-C20heteroaryl is unsubstituted, or substituted by one or more substituents selected from the group consisting of halogen, CN, NO2, OR3a, SR4a, NR5aR6a, COOR3a, (CO)R1a (CO)NR5aR6a, PO(OR1a)2, S(O)mR1a,
C1-C20alkyl, which is unsubstituted, or substituted by one or more halogen, COOR3a, CONR5aR6a, phenyl,C3-C8cycloalkyl, C3-C20heteroaryl, OR3a, SR4a or NR5aR6a, C2-C20alkyl which is interrupted by one or more O, S or NR5a,phenyl, naphthyl, benzoyl and naphthoyl, which phenyl, naphthyl, benzoyl or naphthoyl is unsubstituted, or substituted by OR3a, SR4a or NR5aR6a;R5 and R6 independently of each other are C1-C20alkoxy, which is unsubstituted, or substituted by one or more halogen, phenyl, C1-C8alkylphenyl or C1-C8alkoxyphenyl;
R5 and R6 independently of each other are C2-C20alkoxy, which is interrupted by one or more O, S, NR5a, CO, SO or SO2;
R5 and R6 independently of each other are C6-C20aryloxy or C3-C20heteroaryloxy, which C6-C20aryloxy or C3-C20heteroaryloxy is unsubstituted, or substituted by one or more halogen, C1-C8alkyl, C1-C4haloalkyl, phenyl, C1-C8alkylphenyl, C1-C8alkoxyphenyl, CN, NO2, OR3a, SR4a, NR5aR6a, COOR3a, (CO)R1a or SO2R1a;
R5 together with one of the carbon atoms of R2 or M forms a 5- or 6-membered saturated or unsaturated ring which is uninterrupted, or interrupted by O, S or NR5a, and which 5- or 6-membered saturated or unsaturated ring is unsubstituted or substituted by one or moreC1-C20alkyl, OR3a, SR4a, NR5aR6a, (CO)R1a, NO2, halogen, C1-C4-haloalkyl, CN, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl,or C3-C20cyclalkyl, which is uninterrupted or interrupted by one or more O, S, CO or NR5a;R5 and R6 together with the N-atom to which they are attached form a 5- or 6-membered saturated or unsaturated ring which is uninterrupted, or interrupted by O, S or NR5a, and which 5- or 6-membered saturated or unsaturated ring is unsubstituted or substituted by one or more C1-C20alkyl, OR3a, SR4a, NR5aR6a, (CO)R1a, NO2, halogen, C1-C4-haloalkyl, CN, phenyl,
or C3-C20cyclalkyl which is uninterrupted or interrupted by one or more O, S, CO or NR5a; orR5 and R6 is R5a and R6a, and R5a and R6a are independently of each other are hydrogen, C1-C20alkyl, S(O)m(C1-C8alkyl), O(CO)(C1-C8alkyl), (CO)(C1-C8alkyl), (CO)O(C1-C8alkyl) or CON(C1-C8alkyl)2;R5a and R6a independently of each other are C1-C20alkyl substituted by one or more halogen, OH, SH, CN, C3-C8alkenoxy, OCH2CH2CN, OCH2CH2(CO)O(C1-C8alkyl), O(CO)(C1-C8alkyl), O(CO)(C2-C4)alkenyl, O(CO)phenyl, (CO)OH, (CO)O(C1-C8alkyl), C3-C8cycloalkyl, SO2(C1-C4haloalkyl), O(C1-C4haloalkyl), phenyl, C1-C8alkylphenyl, C1-C8alkoxyphenyl, C3-C8cycloalkyl or C3-C8cycloalkyl which is interrupted by one or more O;or R5a and R6a independently of each other are C2-C20alkyl interrupted by one or more O, S, N(C1-C8alkyl), CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted or substituted by C3-C8cycloalkyl, OH, SH, O(CO)(C1-C8alkyl), (CO)O(C1-C8alkyl), (CO)N(C1-C8alkyl)2,C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, wherein C6-C20aryl,C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, C1-C8alkyl, C1-C8alkoxy, C1-C8alkylsulfanyl or N(C1-C8alkyl)2;R5a and R6a independently of each other are C2-C12alkenyl or C3-C8cycloalkyl, whichC2-C12alkenyl or C3-C8cycloalkyl is uninterrupted or interrupted by one or more O, S, CO, N(C1-C8alkyl) or COO(C1-C8alkyl);R5a and R6a independently of each other are C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, which C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, CN, NO2, OH, C1-C8alkyl, C1-C4haloalkyl, C1-C8alkoxy, phenyl-C1-C3alkyloxy, phenoxy, C1-C8alkylsulfanyl, phenylsulfanyl, N(C1-C8alkyl)2, diphenylamino, (CO)O(C1-C8alkyl), (CO)C1-C8alkyl, (CO)N(C1-C8alkyl)2, phenyl or benzoyl;
R5a and R6a independently of each other are C1-C20alkanoyl or C3-C12alkenoyl, which C1-C20alkanoyl or C3-C12alkenoyl is unsubstituted or substituted by one or more halogen, phenyl, C1-C8alkylphenyl, C1-C8alkoxyphenyl, OH, C1-C8alkoxy, phenoxy, C1-C8alkylsulfanyl, phenylsulfanyl, N(C1-C8alkyl)2 or diphenylamino;
R5a and R6a independently of each other are C1-C20alkoxy, which is unsubstituted or substituted by one or more halogen, phenyl, C1-C8alkylphenyl or C1-C8alkoxyphenyl; or R5a and R6a independently of each other are C2-C20alkoxy, which is interrupted by one or more O, S, N(C1-C8alkyl), CO, SO or SO2;
R5a and R6a independently of each other are C6-C20aryloxy or C3-C20heteroaryloxy, which C6-C20aryloxy or C3-C20heteroaryloxy is unsubstituted or substituted by one or more halogen, C1-C8alkyl, C1-C4haloalkyl, phenyl, C1-C8alkylphenyl, C1-C8alkoxyphenyl, CN, NO2, C1-C8alkoxy, C1-C8alkylsulfanyl, N(C1-C8alkyl)2, CO(OC1-C8alkyl), (CO)(C1-C8alkyl) or SO2-(C1-C8alkyl); or
R5a and R6a together with the N-atom to which they are attached form a 5- or 6-membered saturated or unsaturated ring which is uninterrupted or interrupted by O, S or N(C1-C8alkyl), and which 5- or 6-membered saturated or unsaturated ring is unsubstituted or substituted by one or more C1-C8alkyl, C1-C8alkoxy, C1-C8alkylsulfanyl, N(C1-C8alkyl)2, NO2, halogen, C1-C4haloalkyl, CN, phenyl or C3-C20cyclalkyl which is uninterrupted or interrupted by one or more O, S, CO or N(C1-C8alkyl);R7, R8, R9, R10 and R11 independently of each other are hydrogen, C1-C20alkyl, halogen, CN, NO2, OR3, SR4, NR5R6, COOR3, (CO)R1a, (CO)NR5R6, PO(OR1a)2, S(O)mR1a,wherein the substituents OR3, SR4 or NR5R6 optionally form 5-or 6-membered ring via the radicals R3, R4, R5 or R6 with further substituents on the group X;or R7, R8, R9, R10 and R11 independently of each other are C1-C20alkyl substituted by one or more substituents selected from the group consisting of halogen, OR3, SR4, NR5R6, CN, (CO)OR3, (CO)NR5R6, PO(OR1a)2, S(O)mR1a, C3-C8cycloalkyl which is uninterrupted or interrupted by one or more O, S, CO or NR5, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl andC3-C20heteroarylcarbonyl, which C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, C1-C4haloalkyl, CN, NO2, OR3, SR4, NR5R6, PO(OR1a)2 or S(O)mR1a;R7, R8, R9, R10 and R11 independently of each other are C2-C20alkyl interrupted by one or more O, S, NR5, CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted or substituted by C3-C8cycloalkyl, OH, SH, O(CO)R1a, (CO)OR3, (CO)NR5R6, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, C1-C8alkyl, OR3, SR4 or NR5R6;
R7, R8, R9, R10 and R11 independently of each other are C2-C12alkenyl or C3-C20cycloalkyl, which C2-C12alkenyl or C3-C20cycloalkyl is uninterrupted or interrupted by one or more O, S, CO, NR5 or COOR3; or
R7, R8, R9, R10 and R11 independently of each other are C6-C20aryl or C3-C20heteroaryl, which C6-C20aryl or C3-C20heteroaryl is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, CN, NO2, OR3, SR4, NR5R6, COOR3, (CO)R1a (CO)NR5R6, PO(OR1a)2, S(O)mR1a,
C1-C20alkyl, which is unsubstituted or substituted by one or more halogen, COOR3a, CONR5R6, phenyl,C3-C8cycloalkyl, C3-C20heteroaryl, OR3, SR4 or NR5R6, C2-C20alkyl which is interrupted by one or more O, S or NR5, phenyl, naphthyl, benzoyl and naphthoyl, which phenyl, naphthyl, benzoyl or naphthoyl is unsubstituted or substituted by OR3, SR4 or NR5R6;or R8 and R9, R9 and R10, or R10 and R11 areR12, R13, R14 and R15 independently of each other are hydrogen, C1-C20alkyl, halogen, CN, NO2, OR3, SR4, NR5R6, COOR3, (CO)R1a, (CO)NR5R6, PO(OR1a)2, S(O)mR1a,wherein the substituents OR3, SR4 or NR5R6 optionally form a 5- or 6-membered ring via the radicals R3, R4, R5 or R6 with further substituents on the group X;or R12, R13, R14 and R15 independently of each other are C1-C20alkyl substituted by one or more substituents selected from the group consisting of halogen, OR3, SR4, NR5R6, CN, (CO)OR3, (CO)NR5R6, PO(OR1a)2, S(O)mR1a, C3-C8cycloalkyl which is uninterrupted or interrupted by one or more O, S, CO or NR5, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl andC3-C20heteroarylcarbonyl, which C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl orC3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, C1-C4haloalkyl, CN, NO2, OR3, SR4, NR5R6, PO(OR1a)2 or S(O)mR1a;R12, R13, R14 and R15 independently of each other are C2-C20alkyl interrupted by one or more O, S, NR5, CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted or substituted by C3-C8cycloalkyl, OH, SH, O(CO)R1a, (CO)OR3, (CO)NR5R6, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, C1-C8alkyl, OR3, SR4 or NR5R6; Of
R12, R13, R14 and R15 independently of each other are C2-C12alkenyl or C3-C20cycloalkyl, which C2-C12alkenyl or C3-C20cycloalkyl is uninterrupted or interrupted by one or more O, S, CO, NR5 or COOR3;
R12, R13, R14 and R15 independently of each other are C6-C20aryl or C3-C20heteroaryl, which C6-C20aryl or C3-C20heteroaryl is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, CN, NO2, OR3, SR4, NR5R6, COOR3, (CO)R1a (CO)NR5R6, PO(OR1a)2, S(O)m-R1a,
C1-C20alkyl, which is unsubstituted or substituted by one or more halogen, COOR3a, CONR5R6, phenyl, C3-C8cycloalkyl, C3-C20heteroaryl, OR3, SR4 or NR5R6, C2-C20alkyl which is interrupted by one or more O, S or NR5, phenyl, naphthyl, benzoyl and naphthoyl, which phenyl, naphthyl, benzoyl or naphthoyl is unsubstituted or substituted by OR3, SR4 or NR5R6;R16 and R17 independently of each other are hydrogen, C1-C20alkyl, which is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, OR3, SR4, NR5R6, CN, (CO)OR3, (CO)NR5R6, C3-C8cycloalkyl which is uninterrupted or interrupted by one or more O, S, CO or NR5, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl andC3-C20heteroarylcarbonyl, which C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl orC3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, C1-C4haloalkyl, CN, NO2, OR3, SR4 or NR5R6; OfR16 and R17 independently of each other are C2-C20alkyl interrupted by one or more O, S, NR5, CO, SO or SO2, which interrupted C2-C20alkyl is unsubstituted or substituted by C3-C8cycloalkyl, OH, SH, O(CO)R1a, (CO)OR3, (CO)NR5R6, C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl, wherein C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl or C3-C20heteroarylcarbonyl is unsubstituted or substituted by one or more halogen, C1-C8alkyl, OR3, SR4 or NR5R6; Of
R16 and R17 independently of each other are C2-C12alkenyl or C3-C20cycloalkyl, which C2-C12alkenyl or C3-C20cycloalkyl is uninterrupted or interrupted by one or more O, S, CO, NR5 or COOR3;
R16 and R17 independently of each other are C6-C20aryl or C3-C20heteroaryl, which C6-C20aryl or C3-C20heteroaryl is unsubstituted or substituted by one or more halogen, C1-C20alkyl, C1-C4haloalkyl, phenyl, C1-C20alkylphenyl, C1-C8alkoxyphenyl, CN, NO2, OR3, SR4, NR5R6, COOR3, (CO)R1a or SO2R1a; or
R16 and R17 together with the carbon atom to which they are attached form a 5- or 6-membered saturated or unsaturated ring which is uninterrupted or interrupted by O, S or NR5a, and which 5- or 6-membered saturated or unsaturated ring is unsubstituted or substituted by one or more C1-C20alkyl, OR3a, SR4a, NR5aR6a, (CO)R1a, NO2, halogen, C1-C4haloalkyl, CN, phenyl or C3-C20cyclalkyl which is uninterrupted or interrupted by one or more O, S, CO or NR5a;Ar1 is C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl, C3-C20heteroarylcarbonyl orwhich C6-C20aryl, C3-C20heteroaryl, C6-C20aroyl, C3-C20heteroarylcarbonyl oris unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, CN, NO2, COOR3, (CO)R1a, (CO)NR5R6, PO(OR1a)2, S(O)mR1a,OR3, SR4, NR5R6, wherein the substituents OR3, SR4 or NR5R6 optionally form 5-or 6-membered rings via the radicals R3, R4, R5 or R6 with further substituents on the phenyl ring, C1-C20alkyl which is unsubstituted or substituted by one or more halogen, COOR3, CONR5R6, phenyl,C3-C8Cycloalkyl, C3-C20heteroaryl, OR3, SR4 or NR5R6,C2-C20alkyl which is interrupted by one or more O, S or NR5, C2-C12alkenyl or C3-C20cycloalkyl, which C2-C12alkenyl or C3-C20cycloalkyl is uninterrupted or interrupted by one or more O, S, CO, NR5 or COOR3, phenyl, naphthyl, benzoyl and naphthoyl, which phenyl, naphthyl, benzoyl or naphthoyl is unsubstituted or substituted by OR3, SR4 or NR5R6;or Ar1 isAr2 iswhich is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, CN, NO2, COOR3, (CO)R1a, (CO)NR5R6, PO(OR1a)2, S(O)mR1a,OR3, SR4, NR5R6,C1-C20alkyl which is unsubstituted or substituted by one or more halogen, COOR3, CONR5R6, phenyl, C3-C8cycloalkyl, C3-C20heteroaryl, OR3, SR4 or NR5R6, C2-C12alkenyl or C3-C20cycloalkyl, which C2-C12alkenyl or C3-C20cycloalkyl is uninterrupted or interrupted by one or more O, S, CO, NR5 or COOR3, C2-C20alkyl which is interrupted by one or more O, S or NR5, phenyl, naphthyl, benzoyl and naphthoyl, which phenyl, naphthyl, benzoyl or naphthoyl is unsubstituted or substituted by OR3, SR4 or NR5R6;Z2 is a direct bond, O, S or NR5;m is 1 or 2; andQ is CO or a direct bond.