US Pat. No. 10,457,100

CART WHEEL ASSEMBLY WITH REPLACEABLE TIRE

gowheels, Inc., Raleigh,...

1. A method of applying a tire to a wheel, the method comprising:forming a tire seam with:
a first seam end having at least one locking finger that extends beyond a first seam face, the first seam end having a first seam end first sidewall and a first seam end second sidewall that cover at least a portion of a center ridge that extends along at least a portion of a circumference of the wheel; and
a second seam end having at least one opening to receive the at least one locking finger through a second seam face, the second seam end having a second seam end first sidewall and a second seam end second sidewall that cover at least a portion of the center ridge;
inserting the at least one locking finger into the at least one opening; and
inserting a finger locking pin to engage:
a first passageway in the second seam end first sidewall,
a second passageway in the second seam end second sidewall, a third passageway through a distal portion of the locking finger, and
at least one fourth passageway through the wheel; andwherein after inserting the finger locking pin:the first seam end and second seam end are substantially continuous on an outer circumference of the tire;
the first seam end and second seam end are substantially continuous at the first seam end first sidewall and the second seam end first sidewall covering at least the portion of the center ridge; and
the first seam end and second seam end are substantially continuous at the first seam end second sidewall and the second seam end second sidewall covering at least the portion of the center ridge.

US Pat. No. 10,457,093

STRUCTURE OF BICYCLE WHEEL RIM

Alex Global Technology, I...

1. A structure of a bicycle wheel rim, comprising:an inner rim frame having an inner rim part corresponding to a plurality of spokes, and two lateral ring parts respectively disposed on both sides of the inner rim part, the inner rim frame defining an internal space extending radially from an opening formed between the two lateral ring parts; and
a composite rim body encapsulating the inner rim part and the two lateral ring parts of the inner rim frame, the composite rim body having a first ring segment encapsulating the inner rim part of the inner rim frame, two second ring segments encapsulating the two lateral ring parts of the inner rim frame, a third ring segment having two protrusions and encapsulating terminals of the two lateral ring parts of the inner rim frame, and a supporting part covering the opening of the internal space of the inner rim frame to enclose the internal space defined by the inner rim frame.

US Pat. No. 10,457,082

FLEXOGRAPHIC PRINTING PLATE WITH IMPROVED STORAGE STABILITY

MacDermid Graphics Soluti...

1. A method of making a relief image printing element comprising a plurality of relief printing dots, the method comprising the step of:a) providing at least one photocurable layer disposed on a substrate, the at least one photocurable layer being capable of being selectively crosslinked and cured upon exposure to actinic radiation, the at least one photocurable layer comprising:
i) an ethylenically unsaturated monomer;
ii) a binder; and
iii) a photoinitiator, the photoinitiator exhibiting a quantum yield of initiation (Qi) of more than 0.05 at a 365 nm wavelength;
wherein the substrate comprises a flexible polymer sheet with an ultraviolet absorbing compound incorporated therein, and wherein the substrate has an optical density from 0.5 to 5 in the wavelength range of 365 nm to 450 nm but allows transmission of from 0.1% to 10% of incident light in the wavelength range of 365 nm to 450 nm;
b) imagewise exposing the at least one photocurable layer to actinic radiation to selectively crosslink and cure portions of the at least one photocurable layer; and
c) developing the relief image printing element to separate and remove uncrosslinked and uncured portions of the at least one photocurable layer to reveal a relief image therein, wherein the relief image comprises the plurality of relief printing dots, and
wherein the plurality of relief printing dots exhibit an edge sharpness of the dots such that the ratio of the radius of curvature at the intersection of the shoulder and the top surface of the dot, re, to the width of the top of the dot, p, is less than 5%, and wherein the printing element exhibits improved storage stability and shelf life.

US Pat. No. 10,457,066

IMAGE TRANSFORMATIONS BASED ON DEFECTS

Hewlett-Packard Developme...

1. A system, comprising:a print engine to print a plurality of images on a medium, wherein each one of the plurality of images is printed on a respective ribbon of a plurality of ribbons on the medium, wherein each one of the plurality of ribbons comprises an elongated strip on the medium to receive a respective image that is repeated end-to-end along the elongated strip; and
a controller communicatively coupled with the print engine, the controller to:
detect a failure that results in a defect in a first image of the plurality of images in the respective ribbon of the first image while the print engine is printing the plurality of images,
perform an affine transformation on a second image in the respective ribbon of the first image in response to the failure that is detected to produce a transformed second image, wherein the controller is to perform the affine transformation of the second image by performing a 180-degree rotation of the second image that is repeated for each second image that is printed within the respective ribbon, and
instruct the print engine to print the transformed second image in the respective ribbon of the first image.

US Pat. No. 10,457,060

DROP-ON-DEMAND INKJET PRINT BAR

MOUVENT AG, Solothurn (C...

1. A print bar comprising a mounting assembly and a plurality of drop-on-demand inkjet print modules mounted to the mounting assembly, the modules comprising conduits for continuously circulating ink and each of the modules comprising:a) a drop-on-demand inkjet print head;
b) a local element for controlling the ink pressure, assigned to the print head, processing ink delivered to this print head;the print bar further comprising control circuitry assigned to the print heads of the modules for controlling the local elements of the pint heads of the plurality of print modules, for individually and locally controlling the ink pressure and ink release by the print heads.

US Pat. No. 10,457,053

INK JET PRINTER

ROLAND DG CORPORATION, S...

1. An ink jet printer comprising:a first ink head including a plurality of first nozzles arranged in a first direction and a first nozzle surface on which the first nozzles are disposed;
a second ink head disposed at a side of the first ink head in a second direction perpendicular or substantially perpendicular to the first direction, the second ink head including a plurality of second nozzles arranged in the first direction and a second nozzle surface on which the second nozzles are disposed, a portion of the second nozzles being disposed at a position identical to a portion of the first nozzles in the first direction, the second ink head being shifted from the first ink head in the first direction;
a third ink head disposed at a side of the second ink head opposite to the first ink head in the second direction and at a position identical to a position of the first ink head in the first direction, the third ink head including a plurality of third nozzles arranged in the first direction and a third nozzle surface on which the third nozzles are disposed, the third nozzles being disposed at a position identical to a position of the first nozzles in the first direction;
a fourth ink head disposed at a side of the third ink head opposite to the second ink head in the second direction and at a position identical to a position of the second ink head in the first direction, the fourth ink head including a plurality of fourth nozzles arranged in the first direction and a fourth nozzle surface on which the fourth nozzles are disposed, a portion of the fourth nozzles being disposed at a position identical to the position of the second nozzles in the first direction;
a first wiper that extends in the first direction and wipes the first nozzle surface and the third nozzle surface, and does not wipe the second nozzle surface and the fourth nozzle surface, at a predetermined first position;
a second wiper that extends in the first direction, is disposed at a side of the first wiper in the second direction and is disposed partially at a position identical to a position of the first wiper in the first direction, pivots to an angle identical to an angle of the first wiper and wipes the second nozzle surface and the fourth nozzle surface, and does not wipe the first nozzle surface and the third nozzle surface, at a predetermined second position;
a cleaner that supplies a cleaning solution to the first wiper at a predetermined third position and supplies the cleaning solution to the second wiper at a predetermined fourth position at an identical time;
a remover that removes the cleaning solution remaining on the first wiper at a predetermined fifth position and removes the cleaning solution remaining on the second wiper at a predetermined sixth position at an identical time;
a first driver that moves the first wiper to the first position, the third position, and the fifth position; and
a second driver that moves the second wiper to the second position, the fourth position, and the sixth position.

US Pat. No. 10,457,049

METHOD FOR MANUFACTURING LIQUID EJECTION HEAD AND LIQUID EJECTION HEAD

Canon Kabushiki Kaisha, ...

1. A method for manufacturing a liquid ejection head including a substrate, a flow channel member overlying the substrate and defining a flow channel through which a liquid flows, an ejection opening member overlying the flow channel member and defining an ejection opening through which the liquid is ejected, and an intermediate layer between the substrate and the flow channel member, the method comprising:forming the intermediate layer over the substrate;
forming a first photosensitive resin layer over the intermediate layer;
selectively exposing the first photosensitive resin layer to light, thereby curing the portion of the first photosensitive resin layer defining the flow channel member;
forming a second photosensitive resin layer over the first photosensitive resin layer;
selectively exposing the second photosensitive resin layer to light, thereby curing the portion of the second photosensitive resin layer defining the ejection opening member; and
removing the unexposed portions of the first and the second photosensitive resin layer at one time with a developer;
wherein before the removing with the developer, water absorption W of intermediate layer, water absorption W1 of the exposed portion of the first photosensitive resin layer, and water absorption W2 of the exposed portion of the second photosensitive resin layer satisfy the relationship: W?W1 >W2,
wherein the first photosensitive resin layer and the second photosensitive resin layer are exposed to light having the same wavelength, and
wherein the second photosensitive resin layer is more sensitive to the same wavelength than the first photosensitive resin layer.

US Pat. No. 10,457,046

NOZZLE SUBSTRATE, INK-JET PRINT HEAD, AND METHOD FOR PRODUCING NOZZLE SUBSTRATE

ROHM CO., LTD., Kyoto (J...

1. A nozzle substrate, comprising:a main substrate including a first surface and a second surface;
an adhesion layer formed on the second surface of the main substrate; and
a water repellent film formed on a surface of the adhesion layer, wherein:
the surface of the adhesion layer is at an opposite side to a main substrate side of the adhesion layer,
the nozzle substrate includes a nozzle hole that penetrates in a thickness direction of the nozzle substrate,
the nozzle hole includes a recessed part formed on the first surface of the main substrate, and an ink ejecting path formed on a bottom surface of the recessed part and penetrating a bottom wall of the recessed part,
the ink ejecting path includes a first ink ejecting path penetrating the bottom wall of the recessed part of the main substrate, a second ink ejecting path connected to the first ink ejecting path and penetrating the adhesion layer, and a third ink ejecting path connected to the second ink ejecting path and penetrating the water repellent film,
a transverse sectional area of the third ink ejecting path is approximately equal to a transverse sectional area of the first ink ejecting path,
an inner circumference surface of the third ink ejecting path is approximately perpendicular to the second surface of the main substrate, and
the inner circumference surface of the third ink ejecting path formed on the water repellent film is, in a plan view, depressed to an outside with respect to an inner circumference surface of the first ink ejecting path formed on the main substrate, and a depression amount thereof is equal to or less than 1.5 ?m.

US Pat. No. 10,457,021

BIO RESIN PAPERBOARD CONTAINERS AND CARTONS

1. A bio resin laminated paperboard (BLP) device comprising:a sheet of paperboard having a first side and a second side opposite the first side:
a first layer of bio resin laminated on the first side of the paperboard; and
a second layer of bio resin laminated on the second side of the paperboard,
wherein the bio resin of the first layer of bio resin or the second layer of bio resin, or both, is selected from the group consisting of:
poly (ethylene 2, 5-furandicarboxylate) (PEF);
poly (butylene 2, 5-furandicarboxylate) (PBF);
poly (tri methylene furandicarboxylate) (PTF); and
poly (propylene 2, 5-furandicarboxylate) (PPF).

US Pat. No. 10,457,016

DIFFERENTIAL NEEDLING OF A CARBON FIBER PREFORM

Honeywell International I...

1. A preform for making a carbon-carbon composite comprising:a plurality of layers comprising carbon fibers or carbon-precursor fibers, wherein the plurality of layers are stacked along a central axis to form a stack, wherein the plurality of layers comprise a first exterior layer defining a first major surface of the preform, a second exterior layer defining a second major surface of the preform opposite the first major surface, and at least one interior layer disposed between the first exterior layer and the second exterior layer, the at least one interior layer comprising a peripheral region that forms a portion of an outer surface of the preform; and
a plurality of needled fibers, wherein at least some needled fibers of the plurality of needled fibers extend through two or more layers of the plurality of layers;
wherein the preform has an exterior region and a core region, wherein the exterior region comprises the first exterior layer, the second exterior layer, and the peripheral region of the at least one interior layer;
wherein the core region includes a first composite diameter region that forms an outer diameter of the core region as measured from the central axis, a second composite diameter region that forms an inner diameter of the core region as measured from the central axis, a central region that lies radially between first composite diameter region and second composite diameter region, a first intermediate region that lies radially between the central region and the first composite diameter region, and a second intermediate region that lies radially between the central region and the second composite diameter region,
wherein the plurality of needled fibers define a first needled fiber number density (NFND) in the exterior region, a second NFND in the first composite diameter region, a third NFND in the second composite diameter region, a fourth NFND in the central region, a fifth NFND in the first intermediate region, and a sixth NFND in the second intermediate region,
wherein the second NFND, third NFND, fourth NFND, fifth NFND, and sixth NFND are each greater than the first NFND, and
wherein the fourth NFND is greater than at least one the fifth NFND or the sixth NFND.

US Pat. No. 10,457,012

METHOD FOR FABRICATING COLUMNAR OR LAMELLAR STRUCTURES OF ORGANIC MOLECULES ALIGNED INTO LARGE-AREA SINGLE DOMAIN

KOREA ADVANCED INSTITUTE ...

1. A method for fabricating columnar or lamellar structures of organic molecules aligned in a large-area single domain, the method comprising the steps of:(a) spatially confining organic molecules between a bottom substrate and a top substrate; and
(b) heating the organic molecules confined spatially between the bottom substrate and the top substrate, at a temperature of at least the isotropic transition temperature of the organic molecules, and then cooling the organic molecules, thereby vertically aligning the organic molecules between the bottom substrate and the top substrate,
wherein the large-area single domain has a size ranging from 0.1 mm×0.1 mm to 1 m×1 m and
the organic molecules are supramolecular dendrimer having self-assembly property.

US Pat. No. 10,457,004

METHOD FOR CENTERING A TIRE COMPONENT

VMI HOLLAND B.V., Epe (N...

1. A method for centering a tire component with the use of a centering assembly, wherein the tire component comprises a leading end, a trailing end and a main part between the leading end and the trailing end, wherein the tire component is provided with a first longitudinal edge and a second longitudinal edge extending at least along the main part, wherein the centering assembly comprises a first conveyor, a second conveyor and a drum, wherein the method comprises the steps of;a) placing the tire component on the first conveyor with its leading end facing in a first direction of conveyance defined by the first conveyor;
b) conveying the tire component from the first conveyor towards the second conveyor in the first direction of conveyance;
c) determining, at or near the leading end of the tire component, a lateral position of the first longitudinal edge with respect to a second direction of conveyance defined by the second conveyor;
d) moving the first conveyor transverse to the second direction of conveyance and thereby aligning the first longitudinal edge laterally, at least at the leading end, with respect to the second direction of conveyance along a first edge reference for said first longitudinal edge on the second conveyor;
e) conveying the tire component from the first conveyor onto the second conveyor in the first direction of conveyance while determining a lateral position of the second longitudinal edge with respect to the second direction of conveyance to thereby determine a lateral center of the tire component between the determined lateral positions of the first longitudinal edge and the second longitudinal edge as the tire component is conveyed from the first conveyor onto the second conveyor;
f) conveying the tire component from the second conveyor towards the drum in the second direction of conveyance;
g) moving the drum laterally with respect to the second direction of conveyance to align a lateral center of a desired application position of the tire component on the drum with the determined lateral center of the tire component; and
h) conveying the tire component from the second conveyor onto the drum for application of the tire component at the desired application position.

US Pat. No. 10,456,987

LASER WELDABLE COMPOSITIONS, ARTICLES FORMED THEREFROM, AND METHODS OF MANUFACTURE

SABIC GLOBAL TECHNOLOGIES...

1. A laser weldable composition comprisinga polyester component comprising a poly(butylene terephthalate) homopolymer, a poly(ethylene terephthalate) homopolymer, a poly(cyclohexylenedimethylene terephthalate) homopolymer, a poly(butylene terephthalate) copolymer, a poly(ethylene terephthalate) copolymer, a poly(cyclohexylenedimethylene terephthalate) copolymer, or a combination comprising at least one of the foregoing;
5 to 50 weight percent of a filler; and
10 to 30 wt. % of a poly(ester-carbonate) copolymer comprising
carbonate units of the formula
andester units of the formula

wherein:
T is a C2-20 alkylene, a C6-20 cycloalkylene, or a C6-20 arylene;
R1 and J are each independently
(a) a bisphenol A divalent group of the formula
and(b) a C16 or higher divalent group (b1), (b2), or (b1) and (b2), wherein
(b1) is a phthalimidine divalent group of the formula

wherein
Ra and Rb are each independently a C1-12 alkyl, C2-12 alkenyl, C3-8 cycloalkyl, or C1-12 alkoxy,
each R3 is independently a C1-6 alkyl,
R4 is hydrogen, C1-6 alkyl, or phenyl optionally substituted with 1 to 5 C1-6 alkyl groups,
p, q, and j are each independently 0 to 4, and
(b2) is a third divalent group of the formula

wherein
Rc and Rd are each independently a C1-12 alkyl, C2-12 alkenyl, C3-8 cycloalkyl, or C1-12 alkoxy,
each R6 is independently C1-3 alkyl or phenyl,
Xa is a C6-12 polycyclic aryl, C3-18 mono- or polycycloalkylene, C3-18 mono- or polycycloalkylidene, (Q1)x-G-(Q2)y- group wherein Q1 and Q2 are each independently a C1-3 alkylene, G is a C3-10 cycloalkylene, x is 0 or 1, and y is 1, and
m and n are each independently 0 to 4;whereinthe C16 divalent group (b1), (b2) or a combination of (b1) and (b2) is present in an amount of 40 mol % to 50 mol % based on the total moles of the bisphenol A divalent groups and the C16 divalent group; and
the composition, when molded into an article having a 2.0 mm thickness, provides a near infrared transmission at 960 nanometers of greater than 50% and a thermal resistance according to HDT 1.8 MPa flat (ISO 75/Af) of greater than 160° C.

US Pat. No. 10,456,972

MOLDING UNIT FOR CONTAINERS, EQUIPPED WITH A BOXING INSERT WITH AIR CIRCULATION

SIDEL PARTICIPATIONS, Oc...

1. Molding unit (1) for the forming of a container (2) provided with a hollow recess (3) toward the interior of the container (2), this forming unit (1) comprising:a mold (5) provided with a lateral wall (6) defining a cavity (7) having the impression of at least one portion of the container (2) and that extends along a main axis (X) defining a vertical direction, this lateral wall (6) being provided with a pocket (9) that comes out into the cavity (7);
a boxing device (11) comprising:
an insert (12) mounted in translation relative to the lateral wall (6) along a transverse axis (T) defining a radial direction, between a retracted position in which the insert (12) is at least partially retracted in the pocket (9), and a deployed position in which the insert (12) projects at least partially into the cavity (7) outside of the pocket (9),
an actuator (16) integral with the insert (12) and provided with a piston (17) mounted in translation along the transverse axis (T):
wherein:
the insert (12) is provided with at least one passage (81) that extends from one rear end (82), by which it opens into the pocket (9), to a front end (83) by which it opens onto a front face (13) of the insert (12);
the piston (17) is mounted in a chamber (22) defined in the wall (6) of the mold (5), the piston (17) subdividing the chamber (22) into a rear half-chamber (22A) in communication with a primary fluid duct (46), and a front half-chamber (22B), in communication with both a secondary fluid duct (50), as well as the pocket (9).

US Pat. No. 10,456,964

METHOD FOR PRODUCING A SUPPORT ELEMENT FOR A VEHICLE

FAURECIA INNENRAUM SYSTEM...

1. A method for producing a support element for a transport means, wherein the method comprises the steps of:providing a polypropylene-natural fiber mat, wherein the mat has a basis weight below 1150 g/m2, wherein the polypropylene-natural fiber mat comprises a first type of natural fibers,
pre-heating the mat,
placing the mat in a tool, wherein the tool has a rib-shaped cavity,
pressing the mat into a predefined form by the tool such that the thickness of the mat after the pressing is less than 1.5 mm,
immediately and directly after the pressing, insert molding the mat by injecting a polypropylene-containing material into the rib-shaped cavity, wherein, on account of the insert molding, the material forms stiffening ribs bonded integrally to the mat,
demolding the mat comprising the stiffening ribs.

US Pat. No. 10,456,956

MULTI-CHEMISTRY MICROLATTICE STRUCTURES AND METHODS OF MANUFACTURING THE SAME

HRL Laboratories, LLC, M...

1. A multi-chemistry structure comprising:a plurality of interconnected polymer struts arranged in an integrated lattice comprising a plurality of unit cells;
a first layer of the lattice being formed of a first photopolymerized polymer; and
a second layer of the lattice being formed of a second photopolymerized polymer different from the first photopolymerized polymer,
wherein:
the first layer is substantially continuous across the lattice and comprises 50% or more of each unit cell;
the second layer comprises a remainder of each unit cell;
the first layer is free of the second photopolymerized polymer,
the second layer is free of the first photopolymerized polymer, and
the first and second layers together define the boundary of a simple polygonal or polyhedral unit cell.

US Pat. No. 10,456,950

METHOD OF FORMING TOPPING SHEET AND APPARATUS THEREOF

TOYO TIRE CORPORATION, I...

1. A topping sheet forming method comprising:a feeding and division step of feeding a textile original fabric, obtained by weaving longitudinally aligned tire cords into a cord fabric by use of weft yarns and the textile original fabric comprises at least one surface which has not been topped with rubber, and simultaneously cutting off the weft yarns in predetermined widthwise positions to divide the textile original fabric into a plurality of narrow textile original fabrics; and
a topping step of topping at least one surface of each of the narrow textile original fabrics, which is fed by the feeding and division step, with unvulcanized rubber to form a narrow topping sheet whose width is narrower than the width of the textile original fabric,
wherein in the feeding and division step, the textile original fabric is fed from a cylindrically wound original fabric roll, and the textile original fabric is divided by a wire wound on the original fabric roll in a predetermined winding angle range.

US Pat. No. 10,456,948

COMPONENT, METHOD FOR CONNECTING WOOD ELEMENTS, COMPUTER PROGRAM

Timber Structures 3.0 AG,...

1. Ceiling comprising a plurality of wood elements forming the ceiling, wherein the plurality of wood elements comprises a first wood element, a second wood element and a third wood element, wherein the first wood element comprises a first main fiber direction and a third main fiber direction, wherein the second wood element comprises a second main fiber direction and a fourth main fiber direction, wherein the third wood element comprises a fifth main fiber direction and a sixth main fiber direction, wherein the first main fiber direction, the second main fiber direction and the fifth main fiber direction are parallel, wherein the third main fiber direction, the fourth main fiber direction and the sixth main fiber direction are parallel, wherein the first main fiber direction, the second main fiber direction, the third main fiber direction, the fourth main fiber direction, the fifth main fiber direction and the sixth main fiber direction are parallel to a plane of the ceiling, wherein the first wood element has a first side cutting through the first main fiber direction and a second side cutting through the second main fiber direction, wherein the second wood element has a first side cutting through the second main fiber direction, wherein the third wood element has a first side cutting through the fifth main fiber direction, wherein the first wood element on the first side has at least one area with the first main fiber direction formed by at least one first timber layer of the first wood element and at least one area with the third main fiber direction formed by at least one second timber layer of the first wood element, wherein the first wood element on the second side has at least one area with the first main fiber direction formed by the at least one first timber layer of the first wood element and at least one area with the third main fiber direction formed by the at least one second timber layer of the first wood element, wherein the second wood element on the first side has at least one area with the second main fiber direction formed by at least one first timber layer of the second wood element and at least one area with the fourth main fiber direction formed by at least one second timber layer of the second wood element, wherein the third wood element on the first side has at least one area with the fifth main fiber direction formed by at least one first timber layer of the third wood element and at least one area with the sixth main fiber direction formed by at least one second timber layer of the third wood element, wherein the second side of the first wood element is parallel to the first main fiber direction, wherein the second wood element has a second side parallel to the second main fiber direction,wherein the first side of the first wood element is adhesively bonded to the first side of the second wood element with a distance between the first side of the first wood element and the first side of the second wood element, wherein the distance is greater than 0.3 mm, wherein a gap created by the distance between the first side of the first wood element and the first side of the second wood element is filled with adhesive, wherein the at least one area of the first side of the first wood element with the first main fiber direction is adhesively bonded with the at least one area of the first side of the second wood element with the second main fiber direction, wherein the at least one area of the first side of the first wood element with the third main fiber direction is adhesively bonded with the at least one area of the first side of the second wood element with the fourth main fiber direction, wherein the first side of the first wood element has the shape of a plane surface and the first side of the second wood element has the shape of a plane surface, wherein the first side of the first wood element is adhesively bonded to the first side of the second wood element without a further wood element being adhesively bonded to the second side of the first wood element and the second side of the second wood element for creating a load-bearing connection between the first wood element and the second wood element,
wherein the second side of the first wood element is adhesively bonded to the first side of the third wood element with a distance between the second side of the first wood element and the first side of the third wood element, wherein the distance is greater than 0.3 mm, wherein a gap created by the distance between the second side of the first wood element and the first side of the third wood element is filled with adhesive, wherein the at least one area of the second side of the first wood element with the third main fiber direction is adhesively bonded with the at least one area of the first side of the third wood element with the sixth main fiber direction, wherein the at least one area of the second side of the first wood element with the third main fiber direction is adhesively bonded with the at least one area of the first side of the third wood element with the sixth main fiber direction.

US Pat. No. 10,456,929

NEGATIVE PRESSURE ACTUATED SOFT BENDING ACTUATOR

SCHLUMBERGER TECHNOLOGY C...

1. A soft bending actuator finger for use in conjunction with an evacuator, comprising:a first layer of a first elastomeric material having an outer surface and an inner surface, said first elastomeric material being relatively stiff;
a second layer of a second elastomeric material, said second elastomeric material being relatively compliant relative to said first elastomeric material, said second layer of elastomeric material having a plurality of walls including an outer surface and an inner engagement surface opposite said outer surface, said second layer of elastomeric material defining a plurality of interconnected voids creating pressure equalization of the voids in the second layer and a vacuum port in one of said plurality of walls of the second layer, the vacuum port being in fluid connection with the voids and adapted to be coupled to the evacuator, said second layer bonded to said first layer of elastomeric material along said outer surface of said second layer and said inner surface of said first layer,
wherein, in a first configuration where said plurality of interconnected voids are maintained at a pressure equal to an ambient environment pressure, said soft bending actuator assumes a first position, and in a second configuration where said plurality of interconnected voids are maintained at a pressure below the ambient environment pressure, said soft bending actuator assumes a second, bent position.

US Pat. No. 10,456,924

COORDINATED, COMPLEMENTARY WATER ENVIRONMENT MOBILE ROBOTS

Saudi Arabian Oil Company...

1. A two-part, selectively dockable robotic system providing counterbalanced stabilization during performance of an operation on an underwater target structure, comprising:a first underwater robotic vehicle sized and shaped to at least partially surround the underwater target structure;
a second underwater robotic vehicle sized and shaped to at least partially surround the underwater target structure and be at least partially orientated in a position opposite the first underwater robotic vehicle;
complementary docking mechanisms supported by the first and second underwater robotic vehicles and arranged so the first and second underwater robotic vehicles can selectively couple to each other with the underwater target structure disposed at least partially between the first and second underwater robotic vehicles;
a tool that exerts a first force against the underwater target structure in a first direction, the tool being supported by one of the first and second underwater robotic vehicles; and
a stabilization module that exerts a second force against the underwater target structure in a second direction to at least partially counteract the first force, the stabilization module being supported by the other of the first and second underwater robotic vehicles.

US Pat. No. 10,456,919

MANIPULATOR ARRANGEMENT AND MOVEMENT DEVICE

AMST-Systemtechnik GmbH, ...

1. A movement device being a centrifuge, a medical centrifuge or a training centrifuge, the movement device comprising:a carrier element;
at least one fixing device for accommodating, laying on and/or fixing a human or animal body, said at least one fixing device disposed on said carrier element being disposed rotatably around a main axis;
a manipulator configuration being suitable for contact and/or invasive examination or treatment of the human or animal body under an influence of permanently increased and/or changing acceleration, wherein said manipulator configuration having a functional head, wherein the increased and/or the changing acceleration being defined as a state of acceleration in which said manipulator configuration experiences increased or changing acceleration forces, and as a result of movement and as a result of a change in the movement, the acceleration forces act on said manipulator configuration and on said functional head, and the acceleration forces diverging from acceleration forces of surroundings; and
said manipulator configuration further containing a base and drive devices and at least one of said drive devices is a force-limited drive device having a pressure valve, wherein said functional head being movable relative to said base along a plurality of degrees of freedom movable by said drive devices, wherein a position and/or a contact force of said functional head touching the body is variable with respect to the body under an influence of the increased and/or changing acceleration, wherein a contact force is systemically limited, whereby inadvertent injuries to the body due to said functional head and/or said manipulator configuration are prevented.

US Pat. No. 10,456,918

INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND PROGRAM

Canon Kabushiki Kaisha, ...

1. An information processing apparatus comprising:a model acquiring unit configured to acquire a three-dimensional shape model of a target object;
a display control unit configured to cause a display unit to display the three-dimensional shape model;
a setting unit configured to set a first orientation of the three-dimensional shape model of the target object and a second orientation of the three-dimensional shape model of the target object that is different from the first orientation on the basis of the three-dimensional shape model displayed in the display unit;
a storage unit configured to store a transformation parameter that transforms the first orientation into the second orientation; and
a unit configured to calculate a first position and orientation of the target object by associating the three-dimensional shape model with an imaged target object,
to transform the associated three-dimensional shape model using the transformation parameter, and
to calculate a second position and orientation of the target object by associating the transformed three-dimensional shape model with the imaged target object,
to determine the position and orientation of the target object based on the first position and orientation and second position and orientation of the target object.

US Pat. No. 10,456,917

ROBOT SYSTEM INCLUDING A PLURALITY OF ROBOTS, ROBOT CONTROLLER AND ROBOT CONTROL METHOD

FANUC CORPORARATION, Yam...

1. A robot system including a leading robot and a following robot, the robot system being configured to teach coordinated control in which the leading robot gripping a first workpiece and the following robot gripping a second workpiece are independently moved to a predetermined position, and then, the following robot is operated while following a motion of the leading robot and while maintaining a relative position/orientation between the first and second workpieces, the robot system comprising:a first detecting section configured to detect a first gripping misalignment of a taught position/orientation of the leading robot relative to a predetermined first position/orientation;
a first correcting section configured to correct the position/orientation of the leading robot based on the first gripping misalignment;
a second detecting section configured to detect a second gripping misalignment of a taught position/orientation of the following robot relative to a predetermined second position/orientation; and
a second correcting section configured to correct the position/orientation of the following robot based on at least the second gripping misalignment,
wherein, when the coordinated control is carried out, a teaching point of the following robot is calculated based on both the position/orientation of the leading robot corrected by the first correcting section and the position/orientation of the following robot corrected by the second correcting section.

US Pat. No. 10,456,907

ROBOT ARM AND ROBOT

FANUC CORPORATION, Yaman...

1. A robot arm comprising mounting interface portions at both ends of a long resin arm body,wherein each of the mounting interface portions is provided with: a connecting section that is formed of resin and that is connected to the arm body; and a metal member that is formed of a flat plate-like member or a washer-like member and that is embedded in the resin that forms the connecting section, and that forms a mounting surface; and
the metal member is provided with at least one through-hole that penetrates therethrough in a thickness direction of the flat plate-like member or the washer-like member and through which a mounting screw passes and is embedded in the resin while exposing the mounting surface and a seating surface, for the mounting screw, around the at least one through-hole, the seating surface being located at an opposite side from the mounting surface.

US Pat. No. 10,456,901

TORQUE DRIVING TOOL

WILLIAM TOOLS CO., LTD., ...

1. A torque driving tool, including:a main body, having an axial direction;
a working portion, disposed on one of two ends of the main body for being assembled to a driving bit;
a grip portion, disposed on one of the two ends of the main body opposite to the working portion, selectively rotatable relative to the main body, having at least one receiving groove;
at least one receiving device, each said receiving device including a cover and a receiving portion which is for at least one said driving bit to be received therein, the cover being pivoted to the grip portion, the receiving portion being swingably pivoted to the cover;
wherein the receiving portion includes a plurality of receiving members, said receiving members are respectively for at least one said driving bit to be received therein, two sides of one of two of said receiving members neighboring to each other respectively have a protrusion, two sides of the other of the two of said receiving members neighboring to each other respectively have a slide groove, and the two protrusions are respectively rotatably and slidably arranged within the two slide grooves.

US Pat. No. 10,456,891

GRINDING WHEEL

SHIN-ETSU HANDOTAI CO., L...

1. A grinding wheel comprising a plurality of vitrified bonded grindstone chips arranged on an outer periphery of an annular base metal thereof, the grinding wheel being configured to grind a workpiece with the use of the grindstone chips while rotating the annular base metal,wherein each of the vitrified bonded grindstone chips is configured in such a manner that:
in a rectangular parallelepiped comprising:
a rectangular grinding surface that is placed on an opposite side of the annular base metal and grinds the workpiece; and
four side surfaces adjacent to the grinding surface,
four ridge portions, each of which is provided between the side surfaces, are C-chamfered;
the rectangular grinding surface comprises a plurality of long sides and a plurality of short sides;
each long side is longer than each short side;
each long side of the grinding surface is arranged along the outer periphery of the annular base metal; and
each of the four ridge portions is C-chamfered in a range that is ? or more of a length of each short side of the grinding surface.

US Pat. No. 10,456,868

PROCESSING SYSTEM FOR MULTIPLE DIFFERING WORKPIECES

Trodat GmbH, Wels (AT)

1. A processing system, comprising at least one processing area, one control area), and one input area, wherein via an input and/or display element a user enters a text and/or graphics in an operating software installed therein, which text and/or graphics are passed to a control software running in the control area, wherein into the input area and/or the control area a database is integrated, in which data of the blanks or workpieces to be processed are stored, wherein the control area and/or the input area are designed for the automatic identification of the workpiece stored in the database by detection of the workpiece.

US Pat. No. 10,456,852

ARC WELDING CONTROL METHOD

DAIHEN CORPORATION, Osak...

1. An arc welding control method comprising:cyclically alternating, in feeding of a welding wire, forward feeding and reverse feeding as to a feeding rate, to generate short-circuiting periods and arc periods,
during the arc period, flowing a second welding current smaller than a first welding current after flowing the first welding current,
detecting a phase of the feeding rate upon shifting to the short-circuiting period from the arc period, and
changing at least one of an amount of the first welding current or a length of a conduction period of the first welding current according to the detected phase of the feeding rate, without changing a cycle length of the forward feeding and reverse feeding as to the feeding rate, based on the change in the at least one of the amount of the first welding current or the length of the conduction period of the first welding current.

US Pat. No. 10,456,824

SAFETY POWER ASSIST FOR MANUAL PRESS

BTM Company LLC, Marysvi...

1. A press comprising:(a) a tool including a punch;
(b) a frame;
(c) a manual actuator;
(d) the tool being operably moveable in a longitudinal direction relative to the frame due to movement of the manual actuator;
(e) a switch;
(f) an abutment surface;
(g) an automatically powered actuator coupled to the punch;
(h) a biasing member being compressible when the manual actuator is moved in an operating condition which causes the abutment surface to activate the switch, and the switch activation then operably causing the automatically powered actuator to advance the punch; and
(i) the manual actuator being adapted for reverse movement to retract the tool even after the biasing member has been partially compressed to an intermediate position which is insufficient to cause activation of the switch.

US Pat. No. 10,456,821

FINE BLANKING CAM DIE

MAGNA POWERTRAIN INC., C...

1. A method of fine blanking a slug from a workpiece, the method comprising:positioning a fine blanking cam die between a moveable ram and a base of a press;
positioning a sheet metal workpiece between an axially moveable punch and laterally moveable cam dies;
advancing the punch toward the workpiece and partially piercing the workpiece as the punch travels into the workpiece 20-25% of its thickness;
translating at least one of the cam dies toward the slug to decrease a clearance between the cam dies and the punch after the punch has traveled into the workpiece 20-25% of its thickness such that the cam dies apply a side force to the slug material being formed as the punch continues to travel through the workpiece; and
advancing the punch through the workpiece to separate the slug from the workpiece.

US Pat. No. 10,456,810

INFLATION-ACTIVATED SEPARATOR SCREEN

M-I L.L.C., Houston, TX ...

1. A method of forming a screen, the method comprising:bending a first end of a first hem crimp over an adjacent first portion of the first hem crimp to form a first U-shaped bend;
bending the first U-shaped bend by an angle to form a hemming end portion;
positioning a first edge of a mesh portion proximate a vertex of the angle;
bending the hemming end portion over an adjacent second portion of the first hem crimp to form a second U-shaped bend and to secure the first edge of the mesh portion therebetween the hemming end portion and the adjacent second portion of the first hem crimp; and
bending the second U-shaped bend over and onto the first U-shaped bend to form a third U-shaped bend, such that the first edge of the mesh portion is at least one of hemmed and crimped to the first hem crimp.

US Pat. No. 10,456,803

METHODS OF REMOVING A GLUTINOUS SUBSTANCE FROM AN APPLICATOR

The Boeing Company, Chic...

1. A method of removing a glutinous substance from an applicator, the method comprising:removing an actuator and a plunger, extending from the actuator, from the applicator before the glutinous substance has solidified;
allowing the glutinous substance to solidify inside the applicator, such that the glutinous substance that has solidified comprises a first sealant plug, located inside a first body portion of the applicator, a second sealant plug, integral with the first sealant plug and located partially inside a second body portion of the applicator, and a third sealant plug, integral with the first sealant plug and located inside an end-effector interface, extending from a base portion of the first body portion;
detaching a side cover from the base portion of the first body portion to expose the first sealant plug;
severing the first sealant plug from the second sealant plug at a first junction between the first body portion and the second body portion;
severing the first sealant plug from the third sealant plug at a second junction between the base portion of the first body portion and the end-effector interface;
detaching a tip portion of the applicator from the second body portion to expose a portion of the second sealant plug;
extracting the second sealant plug from the second body portion by pulling the portion of the second sealant plug, exposed by detaching the tip portion from the second body portion away from the second body portion in a direction along the second body portion;
separating the first sealant plug from the base portion of the first body portion; and
extracting the third sealant plug from the end-effector interface of the first body portion.

US Pat. No. 10,456,760

CONTROL OF VIBRATORY/OSCILLATORY MIXERS

Resodyn Corporation, But...

1. A method for controlling a system for mixing one or more materials contained in a mixing vessel, the system including a resonant acoustic mixer operative to vibrate the mixing vessel in an oscillatory motion, the method comprising:determining, by a sensor, a current value of an operating parameter of the system caused by a drive signal waveform;
receiving, by a controller, the current value of the operating parameter from the sensor;
determining, by the controller, a total energy absorbed by the one or more materials based on the received current value of the operating parameter, wherein the operating parameter comprises one of a displacement amplitude, velocity amplitude, acceleration amplitude, and jerk amplitude of the oscillatory motion of the system;
determining, by the controller, a second value for the operating parameter based on the total energy absorbed by the one or more materials; and
changing, by the controller, the current value of the operating parameter to the second value by adjusting the drive signal waveform.

US Pat. No. 10,456,747

HYDROCARBON REVERSE OSMOSIS MEMBRANES AND SEPARATIONS

ExxonMobil Research and E...

1. A membrane structure comprising a first membrane layer and a second membrane layer, the first membrane layer having a pore volume of at least 0.2 cm3/g of pores with a median pore size of at least 20 nm, the second membrane layer comprising a porous carbon layer having a BET surface area of at least about 100 m2/g, the second membrane layer having a pore size distribution comprising a smallest substantial pore size peak having a median pore size of about 3.0 Angstroms to about 50 Angstroms.

US Pat. No. 10,456,731

CO2 CONCENTRATION REDUCING DEVICE

HITACHI CHEMICAL COMPANY,...

1. A device for separating and removing CO2 from a gas containing CO2, the device comprising:a magnetic body;
a plurality of CO2 adsorbent particles that are formed on the magnet body
an adsorbent container which contains the magnetic body; and
a heating unit which heats the plurality of CO2 adsorbent particles by an induction heating.

US Pat. No. 10,456,714

MULTI-PURPOSE GAS SEPARATOR UNIT

William Jacob Management,...

1. A multi-purpose gas separator apparatus, comprising:a unitary vessel defining an interior, the vessel having a test inlet at a first end and having a production inlet at a second, opposite end;
a barrier disposed in the interior and sealing the interior into first and second chambers, the first chamber communicating with the test inlet and adapted for well testing operation, the second chamber communicating with the production inlet and adapted for production operation, the first chamber in communication with a first gas outlet of the vessel for gas, a first water outlet of the vessel for water, and a first condensate outlet of the vessel for condensate, the second chamber in communication with a second gas outlet of the vessel for gas, a second water outlet of the vessel for water, and a second condensate outlet of the vessel for condensate;
a first weir plate disposed in the first chamber and separating the first water outlet on a waterside of the first weir plate from the first condensate outlet on a condensate-side of the first weir plate adjacent the barrier; and
a second weir plate disposed in the second chamber and separating the second water outlet on a waterside of the second weir plate from the second condensate outlet on a condensate-side of the second weir plate adjacent the barrier.

US Pat. No. 10,456,681

GAME SYSTEM, DISPLAY CONTROLLING METHOD, DISPLAY CONTROLLING PROGRAM, AND RECORDING MEDIUM

SONY INTERACTIVE ENTERTAI...

1. A method for causing a game system to display a related picture, the method comprising:executing a game application for a first user using a processor of the game system,
wherein the first user controls a player character in the game application using a game controller;
displaying, on a display of the game system,
a full screen execution screen of the game application;
acquiring over a network, a related picture related to a current state of progress of the first user in the game application;
wherein the related picture is created by a second user different from the first user; and
displaying, on the display, the related picture;
wherein the related picture includes a plurality of play moving pictures uploaded to the network by the second user, the plurality of play moving pictures being that of a same game application as the game application executed for the first user on the game system,
wherein a first play moving picture of the plurality of play moving pictures depicts play information corresponding to a position of the player character that the player character has moved past;
wherein a second play moving picture of the plurality of play moving pictures depicts play information corresponding to a position close to a current position of the player character,
wherein a third play moving picture of the plurality of play moving pictures depicts play information corresponding to a position ahead of the current position of the player character,
wherein the first play moving picture, the second play moving picture, and the third play moving picture are displayed if each has a transmission date within a predetermined time period of a current date, and
wherein the first play moving picture, the second play moving picture, and the third play moving picture are all displayed concurrently and non-overlapping on the display superimposed on the full screen execution screen.

US Pat. No. 10,456,651

GOLF SIMULATOR, AND GOLF SIMULATION METHOD

RD-TEK CO., LTD, Daejeon...

1. A golf simulator comprising:an optical sensor unit configured to detect a movement path of a golf ball using a plurality of optical sensors;
an image inputting unit configured to input a movement image of the golf ball using a spin camera sensor;
a movement information calculating unit configured to calculate a direction and velocity of the golf ball from information obtained from the optical sensor unit;
a spin information calculating unit configured to calculate a spin rate of the golf ball from the input movement image of the golf ball;
a flying trajectory calculating unit configured to calculate a flying trajectory of the golf ball using the calculated direction and velocity of the golf ball and the calculated spin rate of the golf ball; and
a spin rate comparison unit configured to compare the calculated spin rate and a spin rate calculated using data obtained by the optical sensors for excluding an error occurred in the spin rate calculated by the spin information calculating unit.

US Pat. No. 10,456,629

GRAPHENE AND CARBON NANOTUBE REINFORCED GOLF BALL

Callaway Golf Company, C...

1. A golf ball comprising:an inner core comprising a polybutadiene material;
an outer core comprising a polybutadiene material in an amount ranging from 40 to 90 weight percent, zinc diacrylate in an amount ranging from 10 to 50 weight percent, zinc oxide in an amount ranging from 1 to 30 weight percent, peroxide initiator in an amount ranging from 0.1 to 10 weight percent, a graphene material in an amount ranging from 0.01 to 6.0 weight percent of the outer core, and a carbon nanotube (CNT) material in an amount ranging from 0.01 to 6.0 weight percent of the outer core, wherein the graphene material has a surface area ranging from 150 m2/g to 1000 m2/g; and
a cover layer disposed over the outer core;
wherein the inner core has a deflection of more than 0.230 under a load of 200 pounds, and wherein the outer core over the inner core has a deflection of more than 0.080 under a load of 200 pounds.

US Pat. No. 10,456,618

PORTABLE EXERCISE APPARATUS

1. An exercise apparatus comprising:a pair of tracks each extending in a respective longitudinal direction from a first end of a respective one of the tracks to a second end thereof, each one of the tracks including an inner side and an outer side each spanning from the first end to the second end of the respective one of the tracks;
a pair of limb receiving members defining top support surfaces for receiving limbs of a user;
the pair of limb receiving members each being operatively coupled to the respective one of the tracks so as to be slidable relative thereto between the first end of the respective one of the tracks and the second end thereof;
the pair of tracks comprising upper load bearing surfaces supporting the limb receiving members in sliding contact therewith and lower surfaces adapted for resting on a support surface in an operating position of the exercise apparatus;
the pair of tracks being oriented substantially parallel to one another such that the respective longitudinal directions of the tracks are oriented substantially parallel to one another;
the pair of tracks being interconnected by a bridging portion which spans from the inner side of one of the tracks to the inner side of the other one of the tracks;
the bridging portion comprising a hinge defining a folding axis oriented substantially parallel to each one of the respective longitudinal directions of the tracks so that the tracks are movable between the operating position in which the pair of tracks are located in spaced relation from one another with respect to a transverse direction which is cross-wise to the respective longitudinal directions of the pair of tracks such that the inner sides of the tracks are spaced from one another in the transverse direction and the folding axis is located centrally between the tracks with respect to the transverse direction, and a storage position in which the tracks are disposed with the upper load bearing surfaces or the lower surfaces facing one another and the folding axis is located transversely outwardly from the pair of tracks.

US Pat. No. 10,456,600

GRAPHICAL REPRESENTATION OF RADIATION THERAPY

RefleXion Medical, Inc., ...

1. A system for radiation therapy comprising:a rotatable gantry;
a gantry position sensor coupled to the rotatable gantry;
a therapeutic radiation source mounted on the rotatable gantry and movable to a plurality of gantry firing positions by rotating the gantry;
a radiation detector disposed in a radiation beam path of the therapeutic radiation source;
a beam-shaping component disposed in the radiation beam path of the therapeutic radiation source, the beam-shaping component configured to have a radiation-transmitting aperture with a size and shape;
a beam-shaping component sensor configured to detect the size and shape of the radiation-transmitting aperture; and
a display in communication with a controller, wherein
the controller comprises a machine-readable memory medium storing a value of a planned radiation delivery metric over time, and a processor configured to
calculate a real-time value of the radiation delivery metric at multiple time points during a radiation delivery session based on data acquired from the gantry position sensor and/or radiation detector and/or beam-shaping component sensor during the radiation delivery session,
generate a graphical representation depicting the planned radiation delivery metric value and the real-time radiation delivery metric value over the multiple time points, and output the graphical representation to the display.

US Pat. No. 10,456,590

DEVICE AND METHOD FOR LASER TREATMENTS

Biolitec Unternehmensbete...

1. A laser system for medical and cosmetic applications comprising: a. at least one laser source operating at one or more laser wavelengths; b. an electronic visual display having a two-dimensional input interface comprising a rectangular touch-sensitive screen having a vertical edge and a horizontal edge to set/select laser parameters; c. at least one waveguide; d. means to optically connect said laser source to said at least one waveguide; wherein said waveguide is optically coupled with the laser source to convey laser radiation to a treatment site; and wherein a first laser parameter is displayed along a vertical edge of the touch-sensitive screen and a second laser parameter is displayed along a horizontal edge of the touch-sensitive screen, the touch-sensitive screen being configured so that the two laser parameters are simultaneously set by touching the touch-sensitive screen at a single point.

US Pat. No. 10,456,586

USER INTERFACE FOR NEUROSTIMULATION WAVEFORM COMPOSITION

Boston Scientific Neuromo...

1. A system for use by a user to program a neurostimulator configured to deliver neurostimulation to a patient, comprising:a first storage device configured to store waveform building blocks; and
a first user interface including a first display screen, a first user input device, and a first interface control circuit coupled to the first display screen and the first user input device, the first interface control circuit including a waveform composer configured to allow for composition of one of more building blocks of the waveform building blocks and composition of a pattern of neurostimulation pulses using one of more building blocks selected from the waveform building blocks, the waveform composer including:
a library controller configured to display a library management area on the first display screen, the displayed library management area allowing the user to manage the waveform building blocks stored in the storage device; and
a plurality of waveform building block editors each configured to allow the user to compose a type of the waveform building blocks of a plurality of types of the waveform building blocks, the plurality of waveform building block editors including:
a pulse editor configured to display a pulse composition area on the first display screen in response to a user selection for access to the pulse editor, the pulse composition area allowing the user to compose a pulse of the waveform building blocks; and
a burst editor configured to display a burst composition area on the first display screen in response to a user selection for access to the burst editor, the burst composition area allowing the user to compose a burst of the waveform building blocks, the burst including a group of pulses of the waveform building blocks.

US Pat. No. 10,456,579

DIRECT ELECTRICAL STIMULATION DELIVERY SYSTEM FOR THE TREATMENT OF VISUAL DISEASE

Nova Oculus Canada Manufa...

1. An electrotherapeutic system for treating a visual disease, comprising:a signal generator configured to generate a waveform comprising a series of current pulses; and
a headset connectable to the signal generator and configured to deliver the waveform to a skin surface within an eye region of a patient, wherein the headset comprises at least one eyecup electrode including an upper contact pad and a lower contact pad having a contact surface with an area in a range of about 1.10 cm2 to about 1.80 cm2, wherein the eyecup electrode includes a mounting post and a plurality of upper extension arms that provide spacing between the mounting post and the upper contact pad and a plurality of lower extension arms that provide spacing between the mounting post and the lower contact pad to enable contact of the upper and lower contact pads with the skin surface, and wherein the waveform is delivered to the skin surface through both the upper and lower contact pads.

US Pat. No. 10,456,561

NON-COMPLIANT HIGH STRENGTH MEDICAL BALLOON

Cook Medical Technologies...

1. A method of making a reinforced medical balloon, the balloon formed from a balloon structure and including a balloon body member having a circumferential dimension, a longitudinal dimension, and an annular shape in the circumferential dimension; including the steps of:fitting a reinforcement member to the balloon structure, the reinforcement member being formed of an array of reinforcement elements interleaved with one another so as to include a plurality of circumferential elements and a plurality of longitudinal elements, the plurality of longitudinal elements being disposed substantially parallel to the longitudinal dimension and alternatively extending over and then under adjacent ones of the plurality of circumferential elements so as to form the reinforcement member with woven or braided elements, the reinforcement member being fitted such that the plurality of circumferential elements extend in the circumferential dimension of the balloon and are disposed substantially transversally to the longitudinal dimension;
wherein the fitting step includes a step of solely tensing the plurality of circumferential elements following formation of the reinforcement member so as to cause both the plurality of circumferential elements to adopt a circular annular shape in the circumferential dimension and the plurality of longitudinal elements to adopt an undulating shape, and wherein the step of tensing the plurality of circumferential elements is performed without inflating the balloon body member.

US Pat. No. 10,456,560

EXPANDABLE TIP MEDICAL DEVICES AND METHODS

Covidien LP, Mansfield, ...

1. A guidewire comprising:a guidewire body having a proximal end and a distal end; and
a plurality of elements, each having a first end and a second end along a length of the respective element, the plurality of elements having (a) a proximal section fixed at an attachment location at a distal portion of the guidewire body, and (b) a distal section in which the plurality of elements diverge radially outward from the distal end of the guidewire body to form a compliant structure having an expanded profile that is greater than a radial dimension of the distal end of the guidewire body and being resiliently deformable to a reduced profile, where in the expanded profile the compliant structure provides a radial force in an outward circumferential direction from an axis of the guidewire body;
wherein each of the plurality of elements extends distally from the proximal section of the plurality of elements to the distal section, then invert, then extend proximally from the distal section to the proximal section such that both the first and second ends are disposed at the attachment location at the distal portion of the guidewire body.

US Pat. No. 10,456,541

SYSTEM AND RESPIRATION APPLIANCE FOR SUPPORTING THE AIRWAY OF A SUBJECT

KONINKLIJKE PHILIPS N.V.,...

1. A method of supporting the airway of a subject as the subject breathes, the method comprising:during inhalation of a subject, providing a first resistance to gas flow for gas passing from ambient atmosphere into one or more external orifices of the airway of the subject;
during exhalation of the subject, providing a second resistance to gas flow for gas passing from the one or more external orifices of the airway of the subject to ambient atmosphere, wherein the first resistance is lower than the second resistance such that during inhalation gas passes from ambient atmosphere into the one or more external orifices of the airway of the subject substantially unimpeded and during exhalation the second resistance elevates pressure within the airway of the subject such that the elevated pressure supports the airway of the subject;
receiving a pressurized flow of breathable gas;
directing the pressurized flow of breathable gas to the one or more external orifices of the airway of the subject as the subject breathes;
generating one or more output signals that convey information related to the stability of the airway of the subject with one or more sensors; and
adjusting a flow rate of the pressurized flow of breathable gas based on the information in the one or more output signals generated by the one or more sensors.

US Pat. No. 10,456,540

PATIENT INTERFACE SYSTEMS FOR ENSURING EFFECTIVE SEAL

ResMed Pty Ltd, Bella Vi...

1. A patient interface system for delivering pressurized breathable gas to a patient, comprising:a patient interface including first and second portions adapted to seal against the patient's face;
a frame element configured to at least partially support the patient interface on the patient's face when the patient interface is worn; and
a seal maintenance resilient structure disposed between the patient interface and the frame element, the seal maintenance resilient structure being configured to urge the patient interface against the patient's face when the patient interface is worn, the seal maintenance resilient structure consisting of first and second compression springs,
wherein the first and second compression springs are disposed respectively between the first and second portions of the patient interface and the frame element to urge the first and second portions into sealing engagement with the patient's nose when the patient interface is worn, and
wherein a supply tube is connected directly to the frame element and is in fluid communication with the patient interface to provide breathable gas to the patient, the seal maintenance resilient structure being configured such that when a disruptive force is exerted on the supply tube and in turn transferred to the frame element as a pulling force thereon, the seal maintenance resilient structure resists movement of the patient interface caused by the disruptive force thereby decoupling the patient interface from the supply tube.

US Pat. No. 10,456,539

INHALER

KIND CONSUMER LIMITED, L...

1. An inhaler comprising:a reservoir for holding a plurality of doses of a composition to be inhaled;
a housing containing the reservoir and having an outlet end where each dose of the composition exits the inhaler and an opposite end;
a composition flow path extending from the reservoir to the outlet end of the housing along which the composition flows from the reservoir along the flow path and out of a composition orifice towards the outlet end of the housing;
a flexible diaphragm which does not form part of the composition flow path defining a suction chamber on one side of the diaphragm, the suction chamber extending from an air outlet proximate to the outlet end of the housing, and terminating part way along the housing such that the diaphragm separates the suction chamber on one side of the diaphragm from the remainder of the housing on the opposite side of the diaphragm;
a valve element movable with the diaphragm and biased by a biasing force into a first position in which it closes the composition flow path at a position between the reservoir and the composition orifice;
wherein suction on the outlet end reduces the pressure in the suction chamber thereby moving the valve element against the biasing force to a second position to open the composition flow path so that a single dose out of the plurality of doses of the composition held in the reservoir can flow uninterrupted from the reservoir through the composition orifice and out of the outlet end; and
wherein the said biasing force is arranged to return the valve element to the first position to close the composition flow path to stop the flow of the composition from the reservoir through the composition orifice once the single dose is complete and the suction ceases.

US Pat. No. 10,456,534

NASAL SPRAY DELIVERY GUIDE

Cornell University, Ithi...

1. A nasal spray delivery guide comprising:a pair of guide elements spaced apart from one another and configured to be at least partially inserted into respective nostrils of a patient, each guide element comprising an aperture extending therethrough from a base end to a tip end of the guide element;
a flexible connector element attached to and extending between the guide elements;
a wing extending away from one of the guide elements; and
a clamping tab extending away from the wing and upwards and towards one of the guide elements;
wherein the delivery guide has a stable conformation in which an angle between longitudinal axes of the guide elements is between approximately 10 degrees and approximately 30 degrees, and in which an angle between the longitudinal axis of one of the guide elements and an axis perpendicular to the wing is between approximately 5 degrees and approximately 15 degrees.

US Pat. No. 10,456,515

WEARABLE ULTRAFILTRATION DEVICES METHODS AND SYSTEMS

The Trustees of Columbia ...

1. A wearable ultrafiltration apparatus, comprising:a first ultrafilter for filtering a patient's blood along a first fluid path;
a second ultrafilter for filtering the patient's blood along a second fluid path; and
a valve being positionable in a first position for directing the patient's blood along the first fluid path and being positionable in a second position for directing the patient's blood along the second fluid path;
wherein when the valve is in the first position, blood flows along the first fluid path and is prevented from flowing along the second fluid path and when the valve is in the second position, blood flows along the second fluid path and is prevented from flowing along the first fluid path;
wherein when the valve is in the first position, the second ultrafilter is idle and capable of being serviced or replaced, and when the valve is in the second position, the first ultrafilter is idle and capable of being serviced or replaced; and
wherein the valve includes a rod including a handle attached thereto for rotating the rod from the first position to the second position, wherein the rod includes a first edge positioned in a first orientation when the rod is in the first position, the first edge directing the patient's blood to the first ultrafilter along the first fluid path, and wherein when the rod is in the second position the first edge is positioned in a second orientation for directing the patient's blood to the second ultrafilter along the second fluid path.

US Pat. No. 10,456,512

BABY PRODUCT STERILIZER INCLUDING BREAST PUMP

CIMILRE CO., LTD., Cheon...

1. A baby product sterilizer having a breast pump, the sterilizer comprising:a body having a plurality of ultraviolet lamps located at an inside of the body to sterilize and dry baby products accommodated in the inside of the body;
a cap disposed on a front surface of the body;
a cover located at outer surfaces of the body; and
the breast pump disposed between the body and the cover in such a manner as to be controlled by a controller mounted on the cover.

US Pat. No. 10,456,508

DRUG DELIVERY ENDOVASCULAR STENT AND METHOD OF USE

Biosensors International ...

1. A method for making an expandable, metal stent having metal filaments comprising an outer surface region where the outer surface region is coated with a polymer-free limus drug, the stent having a rate of occurrence and/or extent of restenosis or thrombosis resulting from vascular injury in a subject where the rate of occurrence and/or extent of restenosis or thrombosis is reduced relative to that observed by placing at a site of injury, a bare-metal expandable stent formed of interconnected metal filaments or an expandable stent formed of interconnected metal filaments with an outer surface having a coating comprised of a polymer carrier containing a limus drug, the method comprising:roughening regions of the outer surface of the stent filaments to a surface roughness (Ra) of between 20-40 ?in (0.5-1 ?m), and a surface roughness range (Rt) of between 300-700 ?in (7.5-17.5 ?m), and
coating the roughened regions of the stent filaments with a polymer-free limus drug, to a coating thickness greater than the Rt of the roughened stent surface.

US Pat. No. 10,456,489

DECONTAMINATION COVER FOR DECONTAMINATING AN OBJECT

Diversey, Inc., Fort Mil...

6. A decontamination cover to be applied over an object to be decontaminated, the decontamination cover comprisinga sheet-like body comprising a pliable material, an outward facing surface that is substantially opaque to UVC light and an inward-facing surface that is to be arranged opposite a surface of the object to be decontaminated;
a plurality of UVC sources arranged in an array between the outward-facing surface and the inward-facing surface, wherein the UVC sources emit light through lenses provided to the inward-facing surface;
a plurality of spacers extending from the inward-facing surface, wherein the plurality of spacers are arranged in a second array and distributed over the inward facing surface between the lenses of the UVC sources such that the plurality of spacers maintain a suitable separation between the UVC sources and the surface of the object to be decontaminated to promote complete coverage of the surface with UVC light emitted by UVC sources;
a power supply; and
a controller.

US Pat. No. 10,456,488

ULTRAVIOLET TRANSPARENT STRUCTURE FOR ULTRAVIOLET ILLUMINATION USING SCATTERED AND FOCUSED RADIATION

Sensor Electronic Technol...

1. An apparatus, comprising:an ultraviolet transparent structure having an external surface with exposure to an ambient environment and an internal surface separated from the ambient environment by the external surface;
a set of ultraviolet radiation sources configured to generate ultraviolet radiation through the internal surface of the ultraviolet transparent structure towards the external surface and out to the ambient environment for disinfection of the external surface and/or a targeted item located off of the ultraviolet transparent structure, wherein the set of ultraviolet radiation sources includes a first set of ultraviolet radiation sources configured to generate a scattered type of radiation that uniformly disinfects the external surface of the ultraviolet transparent structure and a second set of ultraviolet radiation sources configured to generate a focused type of radiation that disinfects at least one portion of the targeted item; and
a control system configured to manage the ultraviolet radiation generated from the set of ultraviolet radiation sources, the control system directing the first set of ultraviolet radiation sources to generate the scattered type of radiation towards the external surface of the ultraviolet transparent structure and the second set of ultraviolet radiation sources to generate the focused type of radiation at the targeted item.

US Pat. No. 10,456,487

DEVICE TREATMENT

Sensor Electronic Technol...

1. A system, comprising:an open-ended housing having a cavity formed therein that is configured to receive a device;
at least one ultraviolet radiation source located within the cavity of the housing that is configured to emit ultraviolet radiation towards a surface of the device located within the cavity;
a control unit that determines whether the device needs a cleaning treatment in response to the device being placed within the housing, the control unit determining that the device needs the cleaning treatment in response to determining the surface of the device has an amount of at least one of: bacteria, germs, or viruses, that exceeds a predetermined threshold, the control unit activating operation of the ultraviolet radiation source in response to determining that the device needs the cleaning treatment, wherein the activating includes specifying a plurality of operating parameters for the cleaning treatment of the device, the plurality of operating parameters including a cleaning treatment time that the ultraviolet radiation source emits the ultraviolet radiation towards the surface of the device, a dosage of ultraviolet radiation delivered by the ultraviolet radiation source, a power setting for operating the ultraviolet radiation source, and a maximum operating temperature;
an input component that permits a user to adjust at least one of the plurality of operating parameters; and
an output component that provides status information of the cleaning treatment for use by the user.

US Pat. No. 10,456,485

SINGLE-EMITTER LIGHTING DEVICE THAT OUTPUTS A MINIMUM AMOUNT OF POWER TO PRODUCE INTEGRATED RADIANCE VALUES SUFFICIENT FOR DEACTIVATING PATHOGENS

KENALL MANUFACTURING COMP...

1. A lighting device configured to deactivate MRSA bacteria in an environment, the lighting device comprising:at least one lighting element with a single light source configured to provide light, at least a first component of the light having a wavelength of about 405 nm, and at least a second component of the light having a wavelength of greater than 420 nm,
wherein the first component of light has a minimum integrated irradiance of 0.01 mW/cm2 measured from any unshielded point in the environment that is 1.5 m from any point on any external-most luminous surface of the lighting device.

US Pat. No. 10,456,482

PSMA—TARGETED NIR DYES AND THEIR USES

On Target Laboratories, L...

1. A compound selected from the group consisting of:

US Pat. No. 10,456,459

LIPOSOMAL ADJUVANT COMPOSITIONS

Zoetis Services LLC, Par...

1. An essentially saponin-free liposome, wherein said saponin is absent or present at or below the limit of detection, comprising an external lipid bilayer membrane and an internal compartment, the external membrane comprising:a) a quaternary ammonium compound composed of four alkyl chains, two of which are C10-C20 alkyls and the remaining two are C1-C4 alkyls;
b) a sterol selected from the group consisting of ?-sitosterol, stigmasterol, ergosterol, ergocalciferol, and cholesterol;
c) a phospholipid; and
d) a glycolipid of formula I:

wherein, R1 and R2 are independently hydrogen, or a saturated alkyl radical having up to 20 carbon atoms; X is —CH2—, —O— or —NH—; R2 is hydrogen, or a saturated alkyl radical having up to 20 carbon atoms; R3, R4, and R5 are independently hydrogen, —SO42?, —PO42?, —COC1-10 alkyl; R6 is L-alanyl, L-alpha-aminobutyl, L-arginyl, L-asparginyl, L-aspartyl, L-cysteinyl, L-glutamyl, L-glycyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-lysyl, L-methionyl, L-ornithinyl, L-phenyalany, L-prolyl, L-seryl, L-threonyl, L-tyrosyl, L-tryptophanyl, and L-valyl or their D-isomers.

US Pat. No. 10,456,327

PACKAGE FOR FROZEN NUTRIENT PILL

1. A package comprising:a plurality of seamless compartments coupled together;
a different one of said plurality of compartments each including a different respective one of a plurality of respective void spaces and each including a different respective one of one of a plurality of respective void space delimiting surfaces;
a plurality of fill entries, a different one of each said fill entries of said plurality forms a fluent entry into a different one of each of said compartment's respective void space;
a plurality of receptacles, a different one of said plurality of receptacles each include a respective different one of said plurality of void space delimiting surfaces and an external surface, said external surface of each receptacle including a curvilinear portion, the entirety of the curvilinear portion on one side of a support which couples the receptacles together;
wherein at least one fill entry of said plurality forming the fluent entry in one of said compartment's void space is in an elastomeric portion of said package, and said at least one fill entry has a width measured along its minor axis or a diameter which is less than the width of the of the compartment having the at least one fill entry forming the fluent entry into the compartment's void space, wherein the width of the compartment is measured along the compartments minor axis;
wherein each compartment of said plurality has a volume from 0.7 ml to 4 ml; and
wherein each void space delimiting surface of said plurality follows an outline of a separate 3D pill shape; and
wherein each of said fill entries of said plurality of said fill entries circumscribes a different one of said void space delimiting surfaces.

US Pat. No. 10,456,319

FASCIA THERAPY TOOL

1. A rigid tool for use in fascia therapy comprising a handle portion and a blade portion;the handle portion comprising an elongate cylinder having a length from three to five inches and a diameter from three-quarters of an inch to two inches defining a central longitudinal axis;
the blade portion comprising a flat plate having a thickness from one-eighth to three-eighths of an inch and a width from three to five inches, the width being measured from a first transverse side edge to a second transverse side edge and approximately equal to and aligned with the length of the handle portion, and the blade portion being rigidly affixed at a proximal end thereof to and extending out from the handle portion co-planarly with the longitudinal axis; wherein
the blade portion further comprises a distal edge having a curved contour devoid of sharp corners across the width, rounded corners at the intersections of the distal edge and the side edges, and a rounded shape across the thickness.

US Pat. No. 10,456,314

RANGE OF MOTION DEVICE

Bonutti Research, Inc., ...

1. An orthosis configured to stretch tissue around a foot and a toe of a wearer, said orthosis comprising:a first member affixable to the foot;
a second member operatively connected to the first member and affixable to the toe;
a gear fixedly connected to the second member and having a plurality of gear teeth, wherein the gear is configured to rotate relative to the first member to impart movement of the second member relative to the first member; and
a drive assembly operatively coupled to the gear and configured to drive rotation of the gear relative to the first member thereby driving movement of the second member relative to the first member such that the toe moves relative to the foot corresponding with said movement of the second member relative to the first member when the first member is affixed to the foot and the second member is affixed to the toe.

US Pat. No. 10,456,310

BED STEP STOOL AND METHOD OF USE

1. A bed step stool for assisting a user into and out of bed including opposite sides, a head, and a foot, comprising:a first support to be disposed closer to the head of the bed;
a second support to be disposed closer to the foot of the bed;
a step assembly supported between the first support and the second support, the step assembly to enable the user to step thereon for assisting the user into and out of the bed;
a bed attachment that couples the bed step stool to the bed to stabilize the bed step stool,
wherein the first support and the second support define an unobstructed pathway for entry and exit with respect to the bed and the bed step stool that is perpendicular with respect to the sides of the bed whereby the user goes between the first support and the second support to step onto the step assembly and off the step assembly without any obstruction.

US Pat. No. 10,456,293

OPHTHALMIC SYSTEM FOR SUSTAINED RELEASE OF DRUG TO EYE

ForSight Vision5, Inc., ...

1. A method of manufacturing an ocular device configured to be positioned on a surface of the eye at least partially underneath at least one of the upper and lower eyelids and outside a cornea of the eye for delivering at least one therapeutic agent to an eye for an extended period of time, the method comprising:forming a support structure from a length of a first material having a first end region and a second end region into a first shape, wherein the first shape of the support structure provides an overall shape to the ocular device prior to positioning the ocular device on the surface of the eye;
dispersing at least one therapeutic agent into a second material creating a drug matrix, wherein the second material is different from the first material;
molding the drug matrix into a tubular structure having a lumen; and
threading the tubular structure over the length of the support structure such that the support structure extends through the lumen of the tubular structure,
wherein the first shape conforms to a second, different shape after positioning the ocular device onto the surface of the eye, and wherein upon being removed from the eye, the ocular device retains the second shape or changes to a third shape, wherein the third shape is different from both the first shape and the second shape.

US Pat. No. 10,456,289

METHOD AND DEVICE FOR THE MANAGEMENT OF BODY FLUIDS LEAKING FROM A SURGICAL DRAIN TUBE INCISION

ALDEN ADVANCED TECHNOLOGI...

1. A fluid collection system comprising:a baseplate having an adhesive backing configured to couple the baseplate to a patient's skin and defining a wafer having an approximately centrally positioned opening, and a ring shaped, radially-extending wafer connector coupled to said wafer and disposed around said opening configured to receive a first end of a surgical drain tube; and
an appliance including a leaked fluid remover, said leaked fluid remover having a fluid remover connector operable to detachably couple with the wafer connector, the leaked fluid remover connector including a first housing element and a second housing element received by said first housing element and a spacer having an upper surface and a lower surface, the first housing element including an outer septum having a lower surface positioned on or coupled to the upper surface of the spacer, and the second housing element including an inner septum positioned on or coupled to the lower surface of the spacer; and
a leaked fluid collector having an outer film and an inner film, the outer film coupled to an upper portion of the first housing component and the inner film coupled to a lower portion of the first housing component thereby coupling an interior of the leaked fluid collector to the fluid remover connector, wherein coupling of the fluid remover connector to the wafer connector forms a fluid flow chamber therebetween through which leaked fluid from the incision flows through the fluid flow chamber and into the leaked fluid collector.

US Pat. No. 10,456,274

METHOD AND APPARATUS FOR PERFORMING ANTERIOR HIP SURGERY

1. An apparatus for establishing a supine pelvic reference plane for a specific patient, the apparatus comprising:an elongated support arm;
a first leg attached to the elongated support arm;
a second leg slidably attached to the elongated support arm, wherein the second leg slides along the elongated support arm; and
a third leg slidably attached to the elongated support arm, wherein the third leg slides along the elongated support arm, and wherein;
the first, second, and third legs have tips,
the first leg is closer to one end of the elongated support arm than the second leg and the third leg; and
the second and third legs are slidably adjusted relative to the elongated support arm such that:
the tip of the first leg is configured to contact a left anterior superior iliac spine of the specific patient,
the tip of the second leg is configured to contact a right anterior superior iliac spine of the specific patient, and
the tip of the third leg is configured to contact an anterior aspect of an ischium of a pelvis of the specific patient below an acetabulum, and further wherein
the apparatus defines the supine pelvic reference plane for the specific patient, and
the supine pelvic reference plane has a known relationship to a standard reference plane for the specific patient.

US Pat. No. 10,456,252

TRANSCATHETER GUIDEWIRE DELIVERY SYSTEMS, CATHETER ASSEMBLIES FOR GUIDEWIRE DELIVERY, AND METHODS FOR PERCUTANEOUS GUIDEWIRE DELIVERY ACROSS HEART VALVES

Medtronic Vascular, Inc.,...

1. A catheter assembly for crossing a heart valve with a guidewire, the catheter assembly comprising:a tubular support structure adapted to be located at a target location adjacent to the heart valve of a human patient, the tubular support structure including
a proximal segment having a proximal opening at a proximal end,
a distal segment having a distal opening at a distal end, and
a plurality of spaced-apart side ports disposed proximal to the distal opening,
wherein the proximal segment and the distal segment together define therethrough a guidewire lumen configured to slidably receive a first guidewire; and
a wire guide slidably disposed within the tubular support structure, the wire guide having a lumen for slidably receiving a second guidewire through a proximal guidewire port disposed within a first portion of the wire guide outside of the human patient and transmitting the second guidewire through a distal guidewire port disposed within a second portion of the wire guide disposed at the target location adjacent to the heart valve of a human patient,
wherein axial movement of the wire guide relative to the tubular support structure aligns the distal guidewire port of the wire guide with one of the plurality of spaced-apart side ports, and
wherein in a subsequent advancement of the second guidewire, the second guidewire exits the aligned side port.

US Pat. No. 10,456,251

SURGICAL METHODS OF REPLACING PROSTHETIC HEART VALVES

Edwards Lifesciences Corp...

1. A surgical method of implanting a two-stage prosthetic heart valve in a native heart valve annulus of a patient, comprising:providing an expandable anchoring member having a generally tubular expandable body with a proximal end and a distal end, the anchoring member being configured to be constricted to a contracted anchoring member and configured to be enlarged to an expanded anchoring member sized to contact the heart valve annulus;
providing a non-expandable/non-collapsible prosthetic valve member having a peripheral sewing ring on an inflow end and one-way leaflets configured to permit flow in an outflow direction through the valve member;
preparing the patient for surgery by placing him/her on cardiopulmonary bypass;
creating a direct access pathway to the heart valve annulus that permits direct naked eye vision of the heart valve annulus;
delivering the anchoring member to a position within the heart valve annulus and with the proximal end directed toward an outflow side of the annulus;
enlarging the anchoring member to the expanded anchoring member and into contact with the heart valve annulus;
delivering the valve member to the expanded anchoring member such that the one-way leaflets permit flow toward the outflow side of the annulus; and
coupling the sewing ring to the expanded anchoring member.

US Pat. No. 10,456,242

INTRAOCULAR LENS THAT IMPROVES OVERALL VISION WHERE THERE IS A LOCAL LOSS OF RETINAL FUNCTION

AMO Groningen B.V., Gron...

1. An intraocular lens configured to improve vision for a patient's eye, the intraocular lens comprising:an optic comprising a first surface and a second surface opposite the first surface, the first surface and the second surface intersected by an optical axis, the optic being symmetric about the optical axis, wherein the first and the second surface of the optic are aspheric, the first surface having a first radius of curvature and a first conic constant and the second surface having a second radius of curvature and a second conic constant,
wherein the first surface of the optic is configured to face the cornea and the second surface of the optic is configured to face the retina when the optic is implanted in the patient's eye,
wherein the first radius of curvature is less than the second radius of curvature,
wherein the first conic constant is greater than the second conic constant, and
wherein the optic is configured to improve image quality of an image produced by light incident on the patient's eye at an oblique angle with respect to the optical axis and focused at a peripheral location disposed at a distance from the fovea and at an eccentricity between about 1 degree and about 25 degrees with respect to the optical axis at the fovea.

US Pat. No. 10,456,227

METHODS OF SURFACE TREATING TUBULAR MEDICAL PRODUCTS

ENSION INC., Pittsburgh,...

1. A method of treating a tubular medical device with a biomolecule comprising the steps of:a) providing a polyolefin tubular substrate forming a tubular medical device;
b) cleaning the tubular polyolefin substrate;
c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate, wherein step c) includes the steps of the exposing the polyolefin substrate to a reactive gas containing siloxane functional groups and plasma energy to yield a plasma-deposited polysiloxane surface on the surface of the polyolefin substrate prior to exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy, and rendering the plasma deposited polysiloxane surface amino functional; and
d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is heparin at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

US Pat. No. 10,456,205

PATIENT-SPECIFIC FEMOROACETABULAR IMPINGEMENT INSTRUMENTS AND METHODS

Biomet Manufacturing, LLC...

1. A method of resecting a selected portion of an anatomy to improve range of motion of a femur relative to a pelvis in a specific patient, comprising:accessing from a first non-transitory storage medium image data of the patient including at least a portion of the pelvis and a portion of the femur at least including a femoral head of the femur and an acetabulum of the pelvis;
generating and displaying on a computer display a three dimensional (3D) model of at least a portion of the femur and the acetabulum based on the accessed image data;
determining using an interactive surgical planning software program in communication with the first non-transitory storage medium and computer display an appropriate resection of a defect portion of a femoral neck positioned to impinge on the acetabulum to obtain a selected range of motion of the femur relative to the pelvis after a resection;
designing a patient specific guide instrument configured to guide the resection relative to the femoral neck, the patient specific guide instrument including a portion having an inner surface configured to specifically engage the femur of the patient based on the generated 3D model of at least the femur;
transferring to a second non-transitory storage medium a surgical plan including the appropriate resection and the patient specific guide instrument;
manufacturing the designed patient specific guide instrument based on the surgical plan; and
sending the manufactured patient specific guide instrument to a user to perform the resection.

US Pat. No. 10,456,203

PREOPERATIVELY PLANNING AN ARTHROPLASTY PROCEDURE AND GENERATING A CORRESPONDING PATIENT SPECIFIC ARTHROPLASTY RESECTION GUIDE

Howmedica Osteonics Corpo...

1. A method of preoperatively planning an arthroplasty on a knee, the method comprising:a) identify in a computerized coordinate system anatomical landmarks in first medical images of a first resolution, the first medical images being of a knee region including the knee, the anatomical landmarks being in the knee region;
b) identify in the computerized coordinate system the anatomical landmarks in second medical images of a second resolution that is different than the first resolution, the second medical images including at least one of the knee region, an ankle or a hip;
c) merge the first and second medical images by positionally matching in the computerized coordinate system the anatomical landmarks in the first medical images and the anatomical landmarks in the second medical images; and
d) determining in the computerized coordinate system an arthroplasty resection relative to anatomical information resulting from the merged first and second medical images, wherein step d) comprises applying a computerized representation of an implant to the anatomical information resulting from the first medical images of the merged first and second medical images.

US Pat. No. 10,456,202

DEVICE AND METHODS OF IMPROVING LAPAROSCOPIC SURGERY

TransEnterix Europe S.a.r...

1. A device useful for a surgeon and an automated assistant interface, and/or said surgeon and an operating medical assistant interface, during laparoscopic surgery; wherein said device comprises:a. an endoscope, mechanically interconnectable to an automated assistant;
b. at least one instrument;
c. at least one wireless transmitter with at least one operating key; said wireless transmitter and said at least one operating key are in communication with at least one of said at least one instrument; said wireless transmitter is configured to transmit a signal once said at least one operating key is pressed;
d. at least one wireless receiver; configured to receive said signal sent by said transmitter; and
e. at least one conventional laparoscopy computerized system in communication with said wireless receiver and said automated assistant;
wherein said signal sent is associated with said at least one instrument such that once said at least one operating key is pressed said at least one instrument is selected;
wherein said device is configured to control and to direct said endoscope via said conventional laparoscopy computerized system and said automated assistant on said at least one selected instrument;
wherein said at least one selected instrument is selectable following a pressure on said at least one operating key;
further wherein, upon said selection, electronic on-screen identification of a selected at least one laparoscopic instrument is providable, said electronic on-screen identification being real-time overlaid of a real-time image of said selected at least one laparoscopic instrument.

US Pat. No. 10,456,187

MODULATING NERVES WITHIN BONE USING BONE FASTENERS

Relievant Medsystems, Inc...

1. A method of treating back pain of a subject, the method comprising:performing a spinal fusion procedure between two adjacent vertebral bodies;
inserting a distal end of a first pedicle screw within a cancellous bone region of a first vertebral body of the two adjacent vertebral bodies, wherein the first pedicle screw comprises a channel extending along a length of the first pedicle screw;
inserting a first radiofrequency energy delivery device through the channel of the first pedicle screw;
inserting a distal end of a second pedicle screw within the cancellous bone region of the first vertebral body, wherein the second pedicle screw comprises a channel extending along a length of the second pedicle screw;
inserting a second radiofrequency energy delivery device through the channel of the second pedicle screw;
applying radiofrequency energy using the first and second radiofrequency energy delivery devices to conduct heat to the cancellous bone region of the first vertebral body sufficient to ablate a nerve within the cancellous bone region of the first vertebral body.

US Pat. No. 10,456,183

DEVICE IN THE FORM OF A KIT FOR MIXING AND INJECTING A BONE CEMENT

TEKNIMED, Vic en Bigorre...

1. A kit-type device for mixing and injecting a bone cement, comprising a main module, on the one hand, and accessories comprising a removable closing cap and a plurality of functional modules, on the other hand, said accessories being adapted to be each connected or not to the main module of respective phases of use of the device, wherein:the main module is a hollow cylindrical body having an internal wall, an open proximal end and an open distal end, adapted to be each connected to one or a plurality of the accessories of the device, of the phases of use, the distal end (1b) comprising an opening with a diameter equal to the diameter of the cylinder formed by the internal wall of the hollow cylindrical body;
one of the functional modules is a mixer, adapted to be connected, in a mixing phase, to the proximal end of the main module while the distal end of said main module is closed by the closing cap, and to enable a user to mix at least two compounds of the bone cement in the body of the main module;
a further functional module is an injector, adapted to be connected, in a transfer phase following the mixing phase as well as in an injection phase following said transfer phase, to the distal end of the main module instead of the closing cap, and to enable the user to inject the bone cement;
a further still functional module, distinct from the mixer and with no common element with the mixer, is a transferor, adapted to be connected, in the transfer phase, to the proximal end of the main module instead of the mixer and to enable the user to transfer bone cement from the body of the main module to the injector.

US Pat. No. 10,456,181

SPINAL PLATE ASSEMBLY HAVING LOCKING MECHANISM

Globus Medical, Inc., Au...

1. A spinal plate assembly comprising:a base plate defining at least one aperture for receiving a screw, the at least one aperture including a seat and an annular groove terminating at an end wall;
a flexible element having a distal end and a proximal end, the flexible element partially retained within the annular groove and moveable between a locked condition partially blocking the at least one aperture for retaining the screw in the seat and an unlocked condition radially deformable in the annular groove for permitting the screw to be removed from the at least one aperture;
a moveable member for biasing the flexible element toward the unlocked condition, wherein the proximal end of the flexible element is configured to contact the moveable member and the distal end of the flexible element is configured to contact the end wall, and
wherein in the locked condition the flexible element rests adjacent a top of the screw and substantially surrounds a head of the screw.

US Pat. No. 10,456,179

INTRAMEDULLARY ANKLE TECHNIQUE AND SYSTEM

WRIGHT MEDICAL TECHNOLOGY...

1. A system for providing intramedullary guidance to implant an ankle prosthesis, comprising:a first tool sized and configured to form a passage between a tibia and a talus,
a second tool sized and configured to create an intramedullary canal in a distal end of said tibia,
a plurality of modular tibial rod components sized and configured to be disposed in said intramedullary canal and connected to each other in situ to form a single tibial rod component,
a base modular component on a distal end of said single tibial rod component,
an alignment guide configured to attach to said base modular component, and
a cutting guide including at least one aperture configured to guide an instrument in making a tibial cut;
wherein said alignment guide is configured to translate coronal, transverse, and sagittal adjustments from the alignment guide to the cutting guide; and
further comprising at least one broach comprising a circumferential groove configured to engage a holding tool, the circumferential groove extending into an exterior surface of the at least one broach, wherein the at least one broach comprises a first broach component configured to be hingedly coupled to a second broach component to allow alignment of the first broach component and the second broach component such that the first broach component and the second broach component can be inserted into the intramedullary canal to enlarge the diameter of the intramedullary canal.

US Pat. No. 10,456,178

OSSEOINTEGRABLE DEVICE

OSSEOINTEGRATION HOLDINGS...

1. An osseointegration implant arranged, in use, for integration into a skeletal bone of a patient where part of the skeletal bone is missing, comprising:a body and at least one end, the body being arranged, in use to sit within a passageway formed within the bone and substantially mimic a portion of a skeletal bone;
wherein the at least one end includes an enlarged portion arranged to, in use, prevent migration of the implant into the skeletal bone of a patient; and
wherein the enlarged portion is arranged, in use, to sit within a recess formed in an end of the skeletal bone;
wherein the recess is connected to the passageway and is of a larger diameter of the passageway;
wherein the at least one end including the enlarged portion is arranged so that, in use, the end is flush with the end of the skeletal bone; and
wherein the at least one end is configured as an attachment point for a prosthetic limb.

US Pat. No. 10,456,177

INTRAMEDULLARY DEVICE WITH COMPOUND FASTENER TRAJECTORIES

Biomet C.V., Warsaw, IN ...

1. A method, comprising:providing an intramedullary device including a first longitudinal axis extending between a proximal end and a distal end thereof, the intramedullary device comprising:
a proximal region, a distal region, and a mid region positioned between the proximal region and the distal region;
a first bore extending through the intramedullary device between a first opening and a second opening;
a second bore extending through the intramedullary device between the first opening and a third opening; and
a third bore defined by the mid region of the intramedullary device;
inserting the intramedullary device into a femur in a proximal direction from a knee joint; and
inserting a first fastener through the third bore, wherein the first bore is configured to receive a second fastener and the third bore is configured to receive a third fastener, such that the second and third fasteners can extend through the intramedullary device concurrently.

US Pat. No. 10,456,176

APPARATUS AND DEVICES FOR PERCUTANEOUSLY EXTENDING AN EXISTING SPINAL CONSTRUCT

SPINE WAVE, INC., Shelto...

1. A rod connector for attachment to a spinal rod in an existing spinal construct implanted in a patient, comprising:a first portion having an opening therethrough defining an axis, said first portion having a rod receiving opening to receive said existing spinal rod, said existing spinal rod having a longitudinal axis, said rod receiving opening having a first configuration capable of receiving said existing spinal rod in a direction transverse to said longitudinal axis and a second different configuration capable of locking the existing spinal rod to said first portion, said first portion including a rotatable rod engagement member configured to be spaced from said existing spinal rod in a first orientation and in engagement with an undersurface of said existing spinal rod upon rotation to a second orientation;
a second portion having an opening, said axis of the opening of the first portion extending through said opening of said second portion, said rod engagement member being rotatable relative to said second portion; and
a locking element supported by said second portion, said locking element having a first end accessible through said opening of said second portion and an opposite engagement end that upon movement of said locking element along said axis of the opening of the first portion extends into said rod receiving opening to thereby change said rod receiving opening from said first unlocked configuration to said second locked configuration, wherein said existing spinal rod is engaged between said engagement end of said locking element and said rod engagement member to thereby fixedly secure said first portion to said spinal existing rod.

US Pat. No. 10,456,173

SYSTEMS AND METHODS FOR CORRECTING SPINAL DEFORMITIES

NuVasive, Inc., San Dieg...

1. A spinal anchor assembly comprising:a bone screw;
a receiver assembly moveably coupled to the bone screw, the receiver assembly comprising a receiver; and
a collar positioned within the receiver assembly, said collar having a first side and a second side opposing the first side, wherein the first side and the second side are straight and parallel to each other, said collar having a third side and a fourth side opposing said third side, wherein the third side and the fourth side are rounded, and wherein the four sides define an inner cavity; wherein said opposing first and second sides each include a D-shaped facet feature on an interior surface thereof facing said inner cavity; wherein said D-shaped facet feature includes a straight edge portion and a curved portion, wherein the bone screw sits in said collar with a head of the bone screw pivotably coupled to said curved portion of the D-shaped facet feature, wherein the collar is positioned between the head of the bone screw and the receiver such that the head of the bone screw does not directly engage the receiver.

US Pat. No. 10,456,135

SURGICAL INSTRUMENT

Covidien LP, Mansfield, ...

1. A method of operating a surgical instrument, comprising:providing a surgical instrument including a tool assembly and an articulation mechanism,
the articulation mechanism including:
a lower clutch having a plurality of recesses; and
an upper clutch having a plurality of protrusions for engaging at least one of the recesses of the plurality of recesses of the lower clutch; andengaging a first protrusion of the plurality of protrusions of the upper clutch with a first recess of the plurality of recesses of the lower clutch, wherein engagement between the first protrusion of the plurality of protrusions and the first recess of the plurality of recesses retains the tool assembly in a first position, the first recess of the plurality of recesses being larger than other recesses of the plurality of recesses.

US Pat. No. 10,456,109

ULTRASONIC ENDOSCOPE

FUJIFILM Corporation, To...

1. An ultrasonic endoscope comprising:an insertion part that includes a tip, a base end, and a longitudinal axis;
an ultrasonic transducer that is provided at the tip of the insertion part;
a balloon mounting portion which is disposed closer to the base end of the insertion part than the ultrasonic transducer is and on which a balloon wrapping the ultrasonic transducer is detachably mounted;
a supply/discharge pipe line for a balloon that extends in the insertion part;
a groove portion which is formed along the longitudinal axis and includes a base end surface that is provided closer to the tip than the balloon mounting portion in a direction of the longitudinal axis, the base end surface being provided on a surface intersecting the longitudinal axis, and a side surface that is extended from the base end surface toward a distal direction along the longitudinal axis, wherein at least a part of a range in the direction of the longitudinal axis overlaps a range of the ultrasonic transducer in the direction of the longitudinal axis; and
a tip-side opening surface of the supply/discharge pipe line for a balloon, the tip-side opening surface being provided on the base end surface of the groove portion and having components normal to a direction of the longitudinal axis.

US Pat. No. 10,456,104

UNIVERSAL C-ARM CALIBRATION SEAT

1. A universal C-ARM calibration seat comprising:a base, wherein the base is annular and has a central axis, and wherein the base includes a correction plate mounting area;
at least three action units mounted on a side of the base opposite to the correction plate mounting area, wherein each of the at least three action units includes a sliding member; and
a driving and positioning device coaxially mounted to and rotatable relative to the base about the central axis, wherein the driving and positioning device includes a rotating unit configured to actuate each sliding member, wherein when the driving and positioning device rotates relative to the base, the rotating unit actuates each sliding member to simultaneously move toward the central axis.

US Pat. No. 10,456,101

BREAST TOMOSYNTHESIS WITH FLEXIBLE COMPRESSION PADDLE

GENERAL ELECTRIC COMPANY,...

1. A mammography imaging system, comprising:an X-ray source;
an X-ray detector spaced apart from the X-ray source; and
an image data acquisition system for acquiring mammography image data; and
compression assembly positioned between the X-ray source and the X-ray detector, the compression assembly including a movable flexible compression paddle and a support plate spaced apart from each other and configured to hold an object to be imaged therebetween, and wherein the movable flexible compression paddle is formed of a flexible film material or flexible mesh material held by a frame, and wherein the flexible film or flexible mesh material conforms to the shape and size of the object to be imaged.

US Pat. No. 10,456,095

X-RAY DIAGNOSIS APPARATUS AND IMAGE PROCESSING APPARATUS

CANON MEDICAL SYSTEMS COR...

1. An X-ray diagnosis apparatus comprising:processing circuitry configured:
to sequentially generate X-ray images based on X-rays radiated from an X-ray tube and passed through a subject;
to detect, each time one of the X-ray images is generated, a position of a feature point of a device retained in the subject on each of the X-ray images;
to generate, each time the position of the feature point is detected, a correction image by performing at least one of image shift and image transformation of a second X-ray image, based on a position of a feature point detected on a first X-ray image and a position of a feature point detected on the second X-ray image, the first X-ray image being generated before the second X-ray image;
to generate, each time the correction image is generated, an addition correction image obtained by adding together the correction image and at least one correction image generated before the correction image; and
to perform control of displaying, each time the addition correction image is generated, the generated addition correction image sequentially.

US Pat. No. 10,456,094

SYSTEMS AND METHODS FOR NUMERICALLY EVALUATING VASCULATURE

HeartFlow, Inc., Redwood...

1. A method for providing a cardiovascular score for a patient, the method comprising:receiving, using at least one computer system, non-invasively obtained patient-specific image data of multiple coronary arteries of the patient;
creating, using the at least one computer system, a three-dimensional model representing a plurality of portions of the one or more coronary arteries of the patient using the patient-specific image data;
segmenting, using the at least one computer system, one or more geometrical features from the non-invasively obtained patent-specific image data using the three-dimensional model;
analyzing, using the at least one computer system, the one or more geometric features segmented from the non-invasively obtained patient-specific image data to determine multiple characteristics of the one or more coronary arteries;
evaluating, using the at least one computer system, the multiple characteristics of the analyzed one or more geometrical features of the coronary arteries to obtain computer evaluations of the multiple characteristics; and
automatically generating, using the at least one computer system, the cardiovascular score from the computer evaluations of the multiple characteristics.

US Pat. No. 10,456,090

METHOD TO DETERMINE INDIVIDUALIZED INSULIN SENSITIVITY AND OPTIMAL INSULIN DOSE BY LINEAR REGRESSION, AND RELATED SYSTEMS

Bigfoot Biomedical, Inc.,...

1. An insulin delivery system, comprising:an insulin delivery mechanism; and
an insulin delivery control system comprising a memory and a processor operatively coupled to the memory, wherein the processor is configured to:
store data associated with a user of the insulin delivery system, the data comprising glucose concentration measurements, insulin dosing information, and dietary carbohydrate information;
determine rates of change of glucose concentrations responsive to the glucose concentration measurements;
train a first learned time-dependent glucose response model responsive to the rates of change of glucose concentrations and the insulin dosing information;
train a second learned time-dependent glucose response model responsive to the rates of change of glucose concentrations and the dietary carbohydrate information;
receive a time series of dietary carbohydrate intake;
determine glucose responses over a period of time using the first learned time-dependent glucose response model, the second learned time-depend glucose response model, the time-series of dietary carbohydrate intake, and a number of time series of insulin doses;
integrate the glucose responses over the period of time to determine total glucose responses;
determine a time series of insulin doses of the number of time series of insulin doses that minimizes total glucose responses associated with hyperglycemia and hypoglycemia; and
configure the insulin delivery system to provide insulin doses from the insulin delivery mechanism responsive to the determined time series of insulin doses.

US Pat. No. 10,456,073

SYSTEM, METHOD AND APPARATUS FOR RAPID BRIEF FEEDBACK INTRACEREBRAL STIMULATION BASED ON REAL-TIME DESYNCHRONIZATION

THE GOVERNING COUNCIL OF ...

1. A method of monitoring, detecting and stimulating a human patient with epilepsy, said method comprising:monitoring said patient for a seizure onset by intracranial EEG (icEEG) microelectrodes coupled to two hippocampi of the patient to obtain icEEG recordings in real time;
detecting said seizure onset using phase synchronization analysis, the phase synchronization analysis identifying phase desynchronization at theta wave in between the two hippocampi from said icEEG recordings at seizure onset; and
stimulating one of the two hippocampi of the patient upon detection of a seizure onset by said icEEG recordings of said two hippocampi to restore theta wave synchronization in between the two hippocampi.

US Pat. No. 10,456,066

WIRELESS, HANDHELD TISSUE OXIMETRY DEVICE

ViOptix, Inc., Newark, C...

1. A method comprising:enclosing in a housing a first printed circuit board comprising a processor and a memory, wherein the memory is coupled to the processor;
providing a display, coupled to the processor and the housing, wherein the display is visible from an exterior side of the housing, wherein a shape of the housing comprises:
a back surface of the housing which during use, rests between a thumb and forefinger of the hand,
a probe tip comprising a relatively planar surface comprising sensor openings, wherein the relatively planar surface is angled at a non-zero angle relative to the back surface,
a top surface of the housing comprising the display, wherein the top surface is angled at a non-zero angle relative to the back surface, and
a tubular hand grip region, comprising the back surface, coupled between the top surface and the probe tip;
forming a structure of the housing to retain the probe tip, wherein the probe tip is coupled to an exterior side of the enclosure, and the probe tip comprises at least a first sensor opening, a second sensor opening, a third sensor opening, and a fourth sensor opening,
wherein a first distance is between the first and second sensor openings, and a second distance is between the first and third sensor openings, a third distance is between the first sensor opening and the fourth sensor opening, and the first distance is different from the second distance, and the third distance is greater than the first distance and the second distance;
providing a first light source for the first sensor opening, wherein the first sensor opening is coupled via an optical fiber to the first light source;
providing light detectors for the second and the third sensor openings, wherein the second and the third sensor openings are coupled via channels to the light detectors, and the optical fiber has a length that is longer than each of the channels;
providing a second light source for the fourth sensor opening, wherein the first sensor opening is coupled via an optical fiber to the second light source;
configuring the probe tip to receive first data associated with the first and the second sensor openings;
configuring the probe tip to receive second data associated with the first and the third sensor openings; and
configuring the processor to perform spatially-resolved spectroscopy using the first and the second data to determine an oxygen saturation value.

US Pat. No. 10,456,052

ELECTRONIC DEVICE HAVING SEGMENTAL PORTION ON HOUSING THEREOF

Samsung Electronics Co., ...

1. An electronic device comprising:a housing including a first surface, a second surface opposite to the first surface, and a side surface enclosing at least part of a space formed between the first and second surfaces, wherein the side surface includes a first member elongated along the side surface and formed of an opaque material, and at least one second member dividing the first member into at least two segments and formed of a light-transmittable material;
a display arranged on the first surface;
at least one sensor located in the space partially enclosed by the side surface adjacent to the at least one second member, and the at least one sensor is oriented to detect incident light received through the at least one second member;
a communication circuit electrically connected with at least a part of the first member; and
at least one processor electrically connected with the display, the at least one sensor and the communication circuit,
wherein the at least the part of the first member is used as an antenna radiator, and
wherein the at least one second member insulates the at least two segments from each other, and the at least one second member has a smaller width than a width of a light-receiving unit of the at least one sensor.

US Pat. No. 10,456,033

APPARATUS AND METHOD FOR MEASURING BLOOD FLOW OF VESSELS

SHENZHEN CERTAINN TECHNOL...

1. An apparatus for measuring blood flow of vessels, comprising:a light source, a light splitting module, a reference arm module, a sample arm module, a probing module, and a control system;
light emitted by the light source being split by the light splitting module to form a reference light and a probe light, the reference light being incident to the reference arm module, and the probe light being incident to the sample arm module; the sample arm module comprising a scanning unit and a rotatable optical-path shifting device, the rotatable optical-path shifting device being rotatable about a rotation axis, and the probe light having a main light on a rotating, a central line of the main light extending through a rotation axis of the scanning unit;
when the optical-path shifting device is rotated to be in a first position, the probe light being configured to be reflected by the scanning unit to enter the optical-path shifting device, to scan a vessel in a first direction and carry information of the vessel scanned after passing through the optical-path shifting device, to be returned by the sample arm module, and to interfere with the reference light returned from the reference arm module at the light splitting module to generate a first interference light; the first interference light being configured to be probed by the probing module and processed by the control system to obtain a first phase shift signal of the vessel; and
when the optical-path shifting device is rotated to be in a second position, the probe light being configured to be reflected by the scanning unit to enter the optical-path shifting device to scan the vessel in a second direction and carry information of the vessel scanned after passing through the optical-path shifting device, to be returned by the sample arm module, and to interfere with the reference light returned from the reference arm module at the light splitting module to generate a second interference light; the second interference light being configured to be probed by the probing module and processed by the control system to obtain a second phase shift signal of the vessel;
wherein a line extending through a point where the main light of the probe light irradiates on the scanning unit and a point where the main light of the probe light irradiates on the optical-path shifting device is collinear with the rotation axis of the optical-path shifting device.

US Pat. No. 10,456,028

APPARATUS FOR USE IN THE MEASUREMENT OF MACULAR PIGMENT OPTICAL DENSITY AND/OR LENS OPTICAL DENSITY OF AN EYE

Guardion Health Sciences,...

1. An apparatus for use in the measurement of macular pigment optical density in an eye under examination, the apparatus comprising illumination means wherein the illuminating means comprises a blue light source and a green light source which alternately illuminate an area constituted by a light diffusing surface wherein the light diffusing surface comprises an integrating sphere for illuminating an area with light, to provide a stimulus for said eye wherein the apparatus includes a photodetector for measuring the intensity of light in the sphere; intensity adjustment means for adjusting the intensity of light of one of the colors relative to light of another of the colors, until any flicker in the stimulus perceived by the eye is minimized or removed; measurement means for determining the intensity of light of said one of the colors at which said minimizing or removal of flicker occurs; wherein the apparatus includes size selection means for enabling the size of the stimulus to be selected from either a small size, in which all or most of the stimulus falls on the macula of the eye, or a large size, in which the stimulus extends to a portion of the retina of the eye at which there is substantially no macular pigment; and calibration means wherein the calibration means comprises adjusting the intensity using a calibrated photodiode prior to measurement of macular pigment optical density.

US Pat. No. 10,456,024

OVERTUBE AND ENDOSCOPIC SURGICAL DEVICE

FUJIFILM Corporation, To...

1. An overtube comprising:a cylindrical body having a distal end, a base end, and a longitudinal axis;
a distal end opening provided at the distal end of the cylindrical body;
a base end opening provided at the base end of the cylindrical body;
an endoscope insertion passage that is provided along the longitudinal axis of the cylindrical body, couples the distal end opening and the base end opening together, and allows an endoscope insertion part to be inserted therethrough so as to be movable forward and backward;
a fluid passage having a fluid supply and discharge port and a base-end-side connection port, wherein the fluid supply and discharge port is arranged in an inner wall surface of the endoscope insertion passage and opens to an inside of the endoscope insertion passage on a distal-end-side of the endoscope insertion passage, and the base-end-side connection port connects to a fluid supply/suction device that supplies and suctions a fluid; and
a pressure-contact member that positions a distal end of the endoscope insertion part at a first position closer to a base end side of the cylindrical body than a distal-end-side end of the fluid supply and discharge port,
wherein the pressure-contact member includes a locking part having a projection provided in the endoscope insertion passage for locking the endoscope insertion part to the cylindrical body when the endoscope insertion part moves to the base end side of the cylindrical body along the longitudinal axis of the cylindrical body.

US Pat. No. 10,456,014

WATER BOTTLE CAP ASSEMBLIES FOR AN ENDOSCOPIC DEVICE

UNITED STATES ENDOSCOPY G...

1. A water bottle cap assembly for use with an endoscopic device, the assembly comprising:a cap comprising a dome-shaped outer surface and an engageable member, wherein the engageable member is configured to sealingly engage with a water source, and wherein the dome-shaped outer surface defines a plurality of ports to allow for a plurality of output configurations that allow assembly of multiple different products all utilizing the same cap, wherein each of the plurality of ports are initially sealed via a removable sealing member to initially prevent fluid from flowing therethrough,
a plurality of tubular members, wherein each tubular member is coupled to a respective port so as to be in fluid communication therewith, wherein at least one of the tubular members being a single lumen tubular member comprising a coupling member for coupling to a gas supply unit;
an adaptor coupled to an end of one of the tubular members and configured to engage with an endoscopic device, at least one of the tubular members configured to convey at least one fluid between the water source and the endoscopic device; and
a filter disposed on the single lumen member and within 12 inches of the water source to filter contaminants from entering the water source and to prevent backflow to the gas supply unit, wherein the filter comprises pores of about 0.1 micron.

US Pat. No. 10,456,009

IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, AND COMPUTER-READABLE RECORDING MEDIUM

OLYMPUS CORPORATION, Tok...

1. An image processing apparatus, comprising:a hardware processor configured to:
detect, from an image acquired by imaging inside a lumen of a living body, a candidate region for a specific region that is a region where a specific part in the lumen has been captured;
acquire information related to the candidate region;
determine a difficulty of identification of whether or not the candidate region is the specific region;
select a type of identification for use in an identification of whether or not the candidate region is the specific region, wherein the selection is based on the information related to the candidate region and based on the difficulty of identification, and an identification accuracy of the selected type of identification is based on a type of the difficulty of identification; and
identify whether or not the candidate region is the specific region by using the selected type of identification.

US Pat. No. 10,455,993

TOILET

DAIKI CO., LTD., Tokyo (...

1. A toilet comprising:a main body part that receives excreted urine, the main body part including a first bottom surface part and a first side surface part and having a box shape; and
a first shielding member, provided projecting from an inner surface of the first side surface part toward the inside of the main body part, that blocks odor from the urine from rising.

US Pat. No. 10,455,974

CAPSULE KIT FOR USE IN A FOOD PREPARATION MACHINE

Societe des Produits Nest...

1. A kit of at least two capsules each for containing at least one specific food ingredient, the at least two capsules being adapted to be alternatively functionally inserted in a brewing cavity of a food preparation machine for preparation of a multi-ingredient food product, each of the at least two capsules in the kit comprises at least one deformable portion that is deformed when the corresponding capsule is inserted into the brewing cavity, and/or when the brewing cavity is closed, so that at least one machine operational parameter is set by detection of a reaction force on the brewing cavity by the deformed at least one deformable portion, a predetermined value for the at least one machine operational parameter is associated with the reaction force of deformation of the at least one deformable portion, and the at least two capsules in the kit comprise deformable portions with different predetermined mechanical properties to customize machine brewing functional parameters to each of the at least two capsules inserted therein such that the at least two capsules comprise a first capsule that produces a first reaction force of deformation, the first reaction force of deformation associated with a first predetermined value for the at least one machine operational parameter, and the at least two capsules further comprise a second capsule that produces a second reaction force of deformation, the second reaction force different than the first reaction force, the second reaction force associated with a second predetermined value different than the first predetermined value.

US Pat. No. 10,455,930

COSMETIC DEVICE

MTG CO., Ltd., Nagoya (J...

15. A cosmetic device having a main body portion, and a brush portion disposed outside the main body portion, the cosmetic device comprising:a vibration motor disposed in the main body portion and having a rotary shaft equipped with an eccentric weight;
a motor holding portion that holds the vibration motor;
a coupling portion disposed in the main body portion that connects the motor holding portion to the main body portion in a relatively displaceable state; and
a brush attachment portion extending from the motor holding portion and connected to the brush portion,
wherein the brush attachment portion extends in a direction different from an axial direction of the rotary shaft in the vibration motor, and
a vibration direction of the vibration motor is a brush length direction.

US Pat. No. 10,455,911

AUTOMATED UMBRELLA ASSEMBLY

1. An automated umbrella assembly being automatically urged between a deployed position and a stored position wherein said assembly is configured to shade an area without manual manipulation, said assembly comprising:an umbrella being positionable between a deployed position and a stored position, said umbrella including a plurality of ribs, a canopy being positioned on said ribs, a runner, a top tube, a bottom tube and a plurality of stretchers, said runner having a top end, a bottom end and an interior surface, each of said stretchers being pivotally coupled between said top end of said runner and a respective one of said ribs, said runner being slidably positioned around said top tube for sliding upwardly and downwardly along said top tube when said umbrella is positioned between said deployed position and said stored position, said top tube having a lower end and an inside surface, said bottom tube having an upper end, said lower end of said top tube being spaced from and being aligned with said upper end of said bottom tube;
a worm gear being rotatably coupled to said umbrella for urging said umbrella between said deployed position and said stored position;
a pole having said umbrella being pivotally coupled thereto, said pole having an uppermost end, a lowermost end and an outer wall extending therebetween, said pole being hollow, each of said uppermost end and said lowermost end being open, said uppermost end having a notch extending downwardly towards said lowermost end, said outer wall of said pole having a cut therein, said cut extending around an entire circumference of said pole to define a top portion of said pole and a bottom portion of said pole;
a base insertably receiving said pole such that said umbrella is spaced from said base;
a control circuit being positioned in said pole; and
a worm gear motor being coupled to said umbrella, said worm gear being rotatably coupled to said worm gear motor, said worm gear motor being electrically coupled to said control circuit, said worm gear motor rotating said worm gear in a first direction when said worm gear motor is turned on to rotate in a first direction wherein said umbrella is urged into said stored position, said worm gear motor rotating said worm gear in a second direction when said worm gear motor is turned on to rotate in a second direction wherein said umbrella is urged into said deployed position.

US Pat. No. 10,455,910

CANE WRAP AND WALKER SADDLE BAG

1. A walker saddle bag, consisting of:a first flap and a second flap coupled together with a central portion;
an exterior surface defined by the first flap, the second flap, and the central portion;
an interior surface defined by the first flap, the second flap, and the central portion;
a single column of compartments formed on an interior of the first flap;
a single column of compartments formed on an interior of the second flap, and;
one or more hook-and-loop fasteners formed on the interior surface at the central portion and configured to removably secure the central portion around a horizontal bar of one of a walker and a crutch;
wherein each of the compartments on the interior of the first flap comprises a longest length parallel with a longest length of the central portion, and wherein each of the compartments on the interior of the second flap comprises a longest length parallel with the longest length of the central portion.

US Pat. No. 10,455,905

INTERCHANGEABLE ACCESSORY ASSEMBLY AND METHOD OF USE

1. An interchangeable accessory assembly that is operably configured to be selectively removably coupled to a fashionable item, the fashionable item having an exterior side and an interior side opposite the exterior side, the interchangeable accessory assembly comprising:an anchor shell, the anchor shell having:
a first tapered portion; and
a second tapered portion opposite the first tapered portion, the first tapered portion and the second tapered portion defining a smooth outer surface having a length;
a first magnetic member disposed at least partially within the anchor shell; and
an accessory selectively removably mechanically couplable to the anchor shell, the accessory:
having a coupling side including a second magnetic member;
having a decorative side opposite the coupling side; and
being an item of jewelry;
wherein the first magnetic member mechanically couples to the second magnetic member, the first magnetic member and the second magnetic member together having a magnetic strength sufficient to couple each of the anchor shell and the accessory to the fashionable item.

US Pat. No. 10,455,901

INTERCHANGEABLE BUTTON SYSTEM TECHNOLOGY

1. An interchangeable button system for use with fabric, comprising:a fastener comprising a base having a first side comprising a plurality of prongs for extending through fabric and attaching the fastener to the fabric, and a second side;
a base button comprising a mating element on an outer circumference and a plurality of holes for receiving the plurality of prongs of the fastener, such that when the plurality of prongs is received by the plurality of holes, the base button is fastened to the fastener by the prongs; and
an interchangeable cap having a first side comprising a cap face and a second side comprising a recessed inner cap having a matching mating element for engaging the mating element of the base button and prong tracks for receiving ends of the plurality of prongs extending from the fastener;
wherein the interchangeable cap is removable from the base button by uncoupling the mating element of the base button from the mating element of the interchangeable cap, allowing the fastener and the base button to remain fixed to the fabric.

US Pat. No. 10,455,896

THREE-DIMENSIONAL PRINTING OF A TRACED ELEMENT

NIKE, Inc., Beaverton, O...

1. An upper for an article of footwear comprising a traced element, the traced element including:a first polymer layer;
a second polymer layer; and
a strand layer,
wherein the first polymer layer defines a polymer-trace path;
wherein the strand layer comprises a material strand disposed along a strand-trace path and over the first polymer layer, the strand-trace path extends at least partially along the polymer-trace path;
wherein the second polymer layer is disposed along at least a portion of the polymer-trace path and overlaps both the first polymer layer and the strand layer for at least the portion of the polymer-trace path; and
wherein the upper includes a plurality of openings surrounded by a portion of the traced element that includes the first polymer layer, the second polymer layer, and the strand layer.

US Pat. No. 10,455,894

AUXETIC STRUCTURES AND FOOTWEAR WITH SOLES HAVING AUXETIC STRUCTURES

NIKE, Inc., Beaverton, O...

1. A method of customizing a sole structure of an article of footwear, the method comprising:adjusting the flexibility of a sole component of the sole structure, the sole component having an inner surface and an opposite-facing outer surface;
wherein the sole component includes a plurality of inner recesses extending from the inner surface and a plurality of outer recesses extending from the outer surface, the plurality of inner recesses including a blind-hole inner recess, the plurality of outer recesses including a blind-hole outer recess, and wherein the blind-hole inner recess is generally aligned with the blind hole outer recess along a vertical direction;
wherein the plurality of inner recesses and the plurality of outer recesses are arranged to provide the sole component with an auxetic property; and
wherein adjusting the flexibility of the sole component includes selectively cutting or removing material from one or both of the blind-hole inner recess and the blind-hole outer recess.

US Pat. No. 10,455,873

COMBINATION GARMENT AND CARRY-ON BAG

1. A garment that is convertible between a garment configuration and bag configuration, the garment comprising:a back portion and a front portion;
an interior layer at the back portion of the garment;
one or more integrated storage compartments being securable with compartment fasteners;
the integrated storage compartments including external compartments configured for storing items, wherein the external compartments include compartment fasteners and the external compartments are positioned to permit access to stored items in the external compartments;
wherein the garment is convertible into a bag;
wherein the garment includes at least one lower portion fastener on a lower portion of the garment, where the lower portion fastener is configured to releasably attach to an upper portion of the garment in the bag configuration such that an outer surface of the back portion of the garment becomes an outer surface of the bag configuration due to the lower portion fastener attaching the upper portion of the garment to the lower portion of the garment;
wherein the compartment fasteners are configured to keep articles stored inside the integrated storage compartments from falling out of the integrated storage compartments when the garment is in the bag configuration;
wherein converting the garment between the garment configuration and the bag configuration causes the external compartments to become internally located in the bag configuration to conceal the external compartments of the garment configuration; and
wherein the garment includes handles attached on opposite ends of the garment such that when the garment is converted to the bag configuration, the handles meet for carrying the bag configuration; and
wherein one of the integrated storage compartments includes a hanger compartment, the hanger compartment including a rigid or semi-rigid hanger structure positioned in an internal space of the hanger compartment for suspending garments on the hanger structure within the hanger compartment.

US Pat. No. 10,455,840

SYSTEMS AND METHODS FOR RETARDER-TO-OVEN DOUGH PRODUCT

Aryzta LLC, Los Angeles,...

1. A method comprising:mixing ingredients to create a dough for making artisan bread at a desired thickness, the artisan bread to include a hard-crust exterior and a soft interior with a non-uniform cell structure, the ingredients including yeast and in a range of 7-14 wt % not including a chemical leavening agent;
bulk fermenting the dough within a temperature range to allow the yeast to rise and create the non-uniform cell structure within the dough;
sheeting the dough by a sheeter after the bulk fermenting the dough, the sheeter being adjusted to sheet the dough to substantially the desired thickness and without degassing the dough to substantially maintain the non-uniform cell structure developed during the bulk fermenting;
using one or more ultrasonic knives to portion the sheeted dough into portions of dough, the ultrasonic knives portioning the sheeted dough without degassing the dough to substantially maintain the non-uniform cell structure developed during the bulk fermenting;
using a blast chiller to freeze the portions of dough to create frozen portions of dough, the blast chiller freezing the portions of dough without degassing the dough to substantially maintain the non-uniform cell structure developed during the bulk fermenting;
packaging the frozen portions of dough without degassing the dough to substantially maintain the non-uniform cell structure developed during the bulk fermenting, thereby assembling packaged frozen portions of dough that a restaurant can receive, retard the frozen portions of dough in a retarder within a temperature range to create thawed portions of dough without proofing the thawed portions of dough to avoid causing the yeast to additionally rise and in order to substantially maintain the non-uniform cell structure developed during the bulk fermenting, and immediately bake the thawed portions of dough after retarding without proofing the thawed portions of dough before baking because the thawed portions of dough substantially maintain the non-uniform cell structure developed during the bulk fermenting; and
shipping the packaged frozen portions of dough to the restaurant.

US Pat. No. 10,455,838

WIPE FOR KILLING SPORES

American Sterilizer Compa...

1. A process for killing bacterial spores positioned on a substrate, comprising:contacting the bacterial spores with an aqueous composition using an absorbent sheet, the aqueous composition consisting essentially of water, peracetic acid, acetic acid, sulfuric acid, and hydrogen peroxide, the concentration of the hydrogen peroxide in the water being in the range from 0.1 to 0.8% by weight, the concentration of the peracetic acid being in the range from 0.005 to 0.08% by weight, the weight ratio of the peracetic acid to the hydrogen peroxide being in the range from 0.001 to 0.1, the concentration of acetic acid being in the range from 0.001 to 0.3% by weight, and the concentration of sulfuric acid being in the range from 0.001 to 0.3% by weight; and
maintaining the aqueous composition in contact with the bacterial spores at a temperature in the range from about 1° C. to about 40° C. for an effective period of time to effect at least a 4 log reduction in the number of bacterial spores capable of returning to vegetative growth.

US Pat. No. 10,455,815

PET LEASH WITH PET WASTE PICKUP/CARRY BAG

1. An apparatus, comprising:a pet leash having a pet connection end and a handle end;
a resilient frame secured to the pet leash, the resilient frame is moveable between an open configuration and a closed configuration, and the resilient frame is biased to the open configuration, and the resilient frame includes a bag retention mechanism;
the pet leash includes first and second portions between the pet connection end and the handle end, wherein the first and second portions form a loop, and the resilient frame is secured to the first and second portions within the loop formed thereby;
a pouch secured to the resilient frame;
the pouch defining an interior space, an upper end secured to the resilient frame, and a closed bottom end; the upper end of the pouch being open when the resilient frame is at the open configuration and the upper end of the pouch being closed when the resilient frame is at the closed configuration;
a disposable bag removably secured within the interior space of the pouch and lining walls of the pouch; the disposable bag having an upper end adjacent to the upper end of the pouch and releasably secured to the bag retention mechanism, and the disposable bag having a closed bottom end adjacent to the closed bottom end of the pouch, whereby the upper end of the disposable bag is open when the upper end of the pouch is open, and the upper end of the disposable bag is closed when the upper end of the pouch is closed.

US Pat. No. 10,455,809

CONFORMABLE AND REUSABLE LICK DETERRENT

Mark L. Anderson, Spring...

1. A method of using an electronic device worn by an animal or human, comprising:applying a device to a first area of the animal or human, the device comprising a flexible substrate having a first side surface and an opposite second side surface, the substrate being physically conformable in three directions, along its length, width and thickness, the substrate further being stretchable along its length (x) with a first conductive trace and a second conductive trace both on the first side surface of the substrate, the second trace electrically insulated from the first trace, the first and second conductive traces also being conformable in three directions and stretchable at least along their length, including conforming the device to the first area in the three directions; and
electrically connecting a first power source to the device, the first power source including a battery pack connected to the substrate, the battery pack retaining a battery having an anode and a cathode, the battery pack retaining at least one of the anode or the cathode electrically against the first trace, and the battery pack including a terminal extension for connecting the other of the anode or the cathode to the second conductive trace.

US Pat. No. 10,455,769

AGRICULTURAL BALER WITH IMPROVED NEEDLE COUPLING DEVICE

CNH Industrial America LL...

1. A baler comprising:a bale chamber;
a plunger configured to compress crop material in the bale chamber in order to form a bale;
a needle yoke comprising a plurality of needles configured to deliver twine through the bale chamber;
a plurality of knotters configured to receive the twine from the plurality of needles;
a bale length measurement and trigger device configured to measure a length of the bale in the bale chamber and to generate a trigger when a predetermined length is reached;
a driving shaft located above the bale chamber and extending in a traverse direction of the baler;
a gear box configured to continuously rotate the driving shaft when the baler is in operation; and
a needle coupling device between the driving shaft and the needle yoke, the needle coupling device configured for moving the needle yoke from a rest position to a twine delivery position and back when the bale length measurement and trigger device generates a trigger, the needle coupling device comprising:
a crank arm attached to the driving shaft and co-rotating with the driving shaft; and
a plurality of coupling members positioned between the crank arm and the needle yoke, the plurality of coupling members configured for establishing an uncoupling and a coupling between the crank arm and the needle yoke when the bale length measurement and trigger device generates a trigger.

US Pat. No. 10,455,767

CHOPPER KNIFE WITH HARDENING COATING

CNH Industrial America LL...

1. A chopper knife for an agricultural machine, the chopper knife comprising a plate-shaped blade having a front region and a rear region, in which the rear region is adapted for securing the blade to a blade support, the front region comprising at least one elongate cutting edge, the blade confined in transversal direction by longitudinal edges, the blade being provided with a coating extending across a surface of the blade,wherein a width and a thickness of the coating decreases in a direction from the front region towards the rear region of the blade.

US Pat. No. 10,455,752

AGRICULTURAL WHEEL

RFM AG Pty Ltd, Coolamon...

1. A ground driven agricultural wheel in the form of a press wheel or press harrow, comprisinga helical spring coil having
a first end located at a first end of the coil,
a second end located at a second end of the coil,
the first end being a different end to the second end, and
windings extending between the first end and the second end to form the spring coil,
the windings of the coil being flexible so as to be relatively movable with respect to one another in response to flexing movement of the coil,
the first end and the second end being mounted to a hub assembly,
wherein the first end is mounted to the hub assembly by an articulated link,
the articulated link providing relative movement between the first end and the hub assembly to vary the relative distance between the hub assembly and the first end.
US Pat. No. 10,457,829

PHOTOCURABLE RESIN COMPOSITION FOR TRANSFERRING SURFACE FREE ENERGY AND METHOD FOR PRODUCING SUBSTRATE USING SAME

DEXERIALS CORPORATION, T...

1. A photocurable resin composition for transferring surface free energy, the photocurable resin composition comprising:a first compound exhibiting low surface free energy;
a second compound exhibiting surface free energy higher than the surface free energy of the first compound; and
a photopolymerization initiator,
wherein the second compound comprises monofunctional (meth)acrylate, bifunctional (meth)acrylate and trifunctional or higher (meth)acrylate; andwherein a difference in transmittance of the photocurable resin composition to a wavelength of 450 nm between before and after addition of the first compound is less than 79.3%.
US Pat. No. 10,457,835

COATING AGENT COMPOSITION

THREEBOND CO., LTD., Hac...

1. A coating agent composition comprising the following components (A) to (D):(A) 100 parts by mass of a hydrolyzable silicone resin;
(B) 0.1 to 50 parts by mass of a curing catalyst;
(C) 100 to 5000 parts by mass of an organic solvent; and
(D) 10 to 150 parts by mass of dimethylpolysiloxane having one or more alkoxysilyl groups at both ends of the molecular chain, wherein (D) has a viscosity at 25° C. of 100 to 100,000 mPa·s, and
wherein the component (A) is a partial hydrolysis condensate of an alkoxysilane compound represented by the following structural formula (1):
R1x—Si(OR2)4?x  (1),
where R1 and R2 are each independently an optionally substituted aliphatic, alicyclic, or aromatic hydrocarbon group,
x is an integer of 0 to 3, and
a substituent of the aliphatic, alicyclic, or aromatic hydrocarbon group is a halogen, a hydroxyl group, an amino group, an imino group, a nitro group, a mercapto group, a vinyl group, or a carboxyl group.
US Pat. No. 10,455,785

CUCUMBER VARIETY NUN 52011 CUP

NUNHEMS B. V., Nunhem (N...

1. A plant, plant part or seed of cucumber variety NUN 52011 CUP, wherein a representative sample of seed of said cucumber variety is deposited under Accession Number NCIMB 43416.
US Pat. No. 10,457,840

FOAMED ADHESIVE

Zephyros, Inc., Romeo, M...

1. A hot melt adhesive formulation comprising:(i) one or more solid polymers, wherein at least one of the one or more solid polymers has a melt index within the range of about 320 to about 800 g/10 min;
(ii) a thixotropic filler;
(iii) a blowing agent system; and
(iv) a two-component cross linking system comprising:
a first benzoyl peroxide cross linking agent having an activation temperature within a temperature range of 80° C. to 150° C. and a short half-life within the temperature range so that when the adhesive is extruded in place at such a temperature range, the adhesive has a melt viscosity of from about 290 to 913 Pa·s at a shear rate of 100S?1 to flow during the application process but maintains its location on an oily substrate and is dry to the touch due to the presence of the first cross linking agent, and a second cross linking agent with an activation temperature above the activation temperature of the first cross linking agent, so that the adhesive foams and the viscosity of the adhesive is increased to retain gasses generated by the blowing agent system;
wherein the adhesive is adapted for shipment of the oily substrate including the adhesive to a second location prior to exposing the adhesive to temperatures suitable for foaming of the adhesive.
US Pat. No. 10,455,794

SOYBEAN CULTIVAR 51284052

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar 51284052, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125315.
US Pat. No. 10,455,796

SOYBEAN CULTIVAR 76420724

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar 76420724, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125317.
US Pat. No. 10,455,800

SOYBEAN CULTIVAR S170109

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S170109, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125456.
US Pat. No. 10,456,829

METHOD FOR MODIFYING REFRACTORY MOLDING PARTICLES AND REFRACTORY MOLDING PARTICLES OBTAINED THEREBY AND PROCESS FOR PRODUCING MOLD

Itochu Ceratech Corporati...

1. A method of modifying refractory particles for forming a casting mold using a furan resin as a binder, whereby a strength of the casting mold is improved, the method comprising the steps of:providing new refractory particles comprising an artificial aggregate which is artificially produced and which has an apparent porosity of not more than 5%; and
subjecting the artificial aggregate to a heat treatment, at a temperature of 400-1500° C. for a heat treatment period of at least 2 hours to 8 hours in a heating atmosphere having an oxygen concentration of not higher than 15%, to provide modified new refractory particles before forming the casting mold from the modified new refractory particles.
US Pat. No. 10,457,611

ARBUSCULAR MYCORRHIZAL SEED AND IN-FURROW COMPOSITIONS CONTAINING POLYETHYLENE GLYCOL AND METHODS OF THEIR USE

VALENT BIOSCIENCES LLC, ...

13. A plant growth composition comprising from about 0.2% to about 20% w/w Mycorrhizae technical powder concentrate from about 66% to about 97% w/w of a polyethylene glycol, and from about 0.5% to about 5% w/w of 1,2-propanediol cyclic carbonate wherein % w/w denotes percent weight by total weight of the composition.
US Pat. No. 10,456,337

OIL-IN-OIL TYPE COSMETIC COMPOSITION

SHISEIDO COMPANY, LTD., ...

1. A cosmetic composition comprising:(a) 10 to 70% by mass of non-volatile hydrocarbon oil,
(b) 5 to 60% by mass of methylphenylpolysiloxane, and
(c) 0.5 to 8% by mass of an ester of dextrin and fatty acid having 12-22 carbon atoms,wherein the ester of dextrin stabilizes an oil-in-oil emulsion of the non-volatile hydrocarbon and the methylphenylpolysiloxane, wherein the cosmetic composition does not comprise a volatile hydrocarbon oil, wherein the non-volatile hydrocarbon oil comprises a hydrogenated polyisobutene having a molecular weight of 1,000 to 2,650, andwherein the non-volatile hydrocarbon oil (a) and methylphenylpolysiloxane (b) are formulated at a ratio (mass ratio) of (a)/[(a)+(b)]=0.5 to 0.8.
US Pat. No. 10,456,339

ORGANIC HYDROPEROXIDE REDUCTION IN PERFUMERY RAW MATERIALS

FIRMENICH SA, Geneva (CH...

1. A method, wherein the method reduces the peroxide value (POV) of a perfume, body care product, cosmetic product, homecare product, perfumery raw material, flavored article, or food raw material, the method comprising:a. adding an ?-oxocarboxylic acid to the perfume, body care product, cosmetic product, homecare product, perfumery raw material, flavored article, or food raw material having a first POV level;
b. mixing the ?-oxocarboxylic acid into the perfume, body care product, cosmetic product, homecare product, perfumery raw material, flavored article, or food raw material for a time sufficient to reduce the first POV level to a pre-determined second lower level; and
c. removing the ?-oxocarboxylic acid from the formulated perfume, body care product, cosmetic product, homecare product, perfumery raw material, flavored article, or food raw material having the pre-determined second lower level.
US Pat. No. 10,455,833

METHODS OF RAPIDLY PREVENTING THE SPREAD OF AVIAN INFLUENZA VIRUS IN POULTRY FLOCKS

AGRO INNOVATION INTERNATI...

1. A method of rapidly inactivating Avian Influenza Virus (AIV) in the housing of a poultry flock in need thereof, comprising:applying a powdered composition to the floor of said housing in amounts effective to rapidly inactivate AIV, said floor of said poultry housing comprising bedding material, said composition comprising (i) salicylic acid in an amount ranging from about 1 wt % to about 5 wt %; and (ii) aluminum sulfate in an amount ranging from about 5 wt % to about 15 wt % and calcium sulfate in an amount ranging from about 80 wt % to about 90 wt %, wherein said inactivation of AIV occurs within about ten to fifteen minutes after application of said composition, and wherein said AIV is a low pathogenic strain.
US Pat. No. 10,456,356

USE OF ENCAPSULATED CELL THERAPY FOR TREATMENT OF OPHTHALMIC DISORDERS

Neurotech USA, Inc., Cum...

1. A method of improving optic nerve regeneration; preserving or improving the ganglion cell complex, the thickness of the outer retinal layer, or both the ganglion cell complex and the thickness of the outer retinal layer; or preserving or improving the retinal fiber layer in a patient in need thereof comprising: implanting into an eye of the patient a biocompatible capsule comprisinga) a core comprising 0.5-1×106 ARPE-19 cells that are genetically engineered to secrete a therapeutically effective amount of CNTF upon implantation, wherein the therapeutically effective amount is between 0.1 and 20 ng/day;
b) a semi-permeable membrane surrounding the core, wherein the membrane has a molecular weight cut off of 50 kD, permits the diffusion of the CNTF therethrough, and is between 90 and 120 ?m thick; and
c) a matrix disposed within the semi-permeable membrane, wherein said matrix comprises monofilaments that are twisted into a yarn that is in non-woven strands, wherein the cells are distributed thereon, and wherein the monofilaments comprise polyethylene terephthalate (PET) fibers that comprise 40-85% of the internal volume of the capsule;
wherein said biocompatible capsule produces 0.6-5.0 ng/day of CNTF for at least 12 months post implantation, and
wherein the capsule is configured as a hollow fiber having an internal diameter of 0.9-1.2 mm and a length of 4-11 mm.
US Pat. No. 10,455,849

METHOD FOR THE PREPARATION OF A PROTEIN PEPTIDE, A PROTEIN PEPTIDE AND USE THEREOF

INFINITUS (CHINA) COMPANY...

1. A method for the preparation of a protein peptide comprising the steps:(1) mincing tuna from which head and viscera has previously been removed, heating after adding water or heating with water steam to obtain pretreated tuna;
(2) enzymolysing the pretreated tuna, deactivating the enzyme, centrifuging to obtain a supernatant;
(3) concentrating the supernatant and drying to obtain the peptide powder of interest, which is the protein peptide,
wherein the protease used in enzymolysis is one or more of acid protease and NEUTRASE® (neutral, zinc metallo endo-protease from Bacillus amyloliquefaciens), and the total amount of proteases used is 0.2% to 3.2% by weight of the pretreated tuna.
US Pat. No. 10,457,911

MEDIUM FOR STEM CELL USE

AJINOMOTO CO., INC., Tok...

1. A medium for culturing an iPS cell, comprising:polyvinyl alcohol; and
an albumin,
wherein the albumin and the polyvinyl alcohol are included in the medium in a weight ratio of 1:1.1 to 100, and
an amount of fatty acid binding to the albumin is not more than 2.2 mg per 1 g of the albumin.
US Pat. No. 10,457,915

CHEMICAL DIFFERENTIATION OF PLURIPOTENTSTEM CELLS INTO RETINAL EPITHELIAL CELLS

International Stem Cell C...

1. A method of producing retinal pigmented epithelial cells (RPEs) comprising: a) culturing human pluripotent stem cells (hpSCs) on a feeder layer; b) transferring the hpSCs to feeder layer free culture conditions; c) culturing the hpSCs simultaneously with a ROCK inhibitor, a TGF?R-1 inhibitor, a Wnt inhibitor, and a BMP inhibitor for a period of time sufficient to allow for the production of retinal epithelial progenitor cells; and d) culturing the retinal epithelial progenitor cells with a glycogen synthase kinase 3 (GSK-3) inhibitor, for a period of time sufficient to allow for the production of RPEs, wherein the RPEs express at least one RPE specific markers selected from the group consisting of POU5F1, BEST-1, MITF, OTX2, RLPB1, RPE65, SERPINF1, ZO1, MELANOSOME or a combination thereof.
US Pat. No. 10,456,380

COMPOSITIONS AND METHODS OF TREATING MUSCULAR DYSTROPHY WITH THROMBOXANE-A2 RECEPTOR ANTAGONISTS

CUMBERLAND PHARMACEUTICLS...

1. A method of treating Duchenne muscular dystrophy in a patient in need of treatment thereof, comprising administering a therapeutically effective amount of a thromboxane A2 receptor antagonist to the patient, wherein the thromboxane A2 receptor antagonist is [1S-(1?,2?,3?,4?)]-2-[[3-[4-[(Pentylamino)carbonyl]-2-oxazolyl-7-oxabicyclo[2.2.1]hept-2-yl]methyl]-benzenepropanoic acid (Ifetroban), or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,456,389

EXTENDED RELEASE NICOTINAMIDE FORMULATION

CONARIS RESEARCH INSTITUT...

1. A pharmaceutical composition comprising extended release granules of nicotinamide that include a granule core and at least 13% w/w of an ethylcellulose film coating, wherein the granule cores have a mean particle size less than 800 ?m and comprise a conductive filler in an amount of 35-79% w/w, wherein the granules are capable of remaining substantially free of static electricity at up to 10% weight gain of ethylcellulose film coating, and wherein the pharmaceutical composition releases the nicotinamide over at least 3 hours when assessed in a USP paddle apparatus operated at 100 rpm using purified water as a release medium.
US Pat. No. 10,457,933

MICROBIAL STRAIN IMPROVEMENT BY A HTP GENOMIC ENGINEERING PLATFORM

Zymergen Inc., Emeryvill...

1. A functionally agnostic method for rehabilitating and improving the phenotypic performance of a production microbial strain, which does not require prior knowledge regarding the underlying function of a given genetic variation, the method comprising the steps of:a. providing a parental lineage microbial strain and a production microbial strain derived therefrom, wherein the production microbial strain comprises a plurality of identified genetic variations selected from single nucleotide polymorphisms, DNA insertions, and DNA deletions, not present in the parental lineage microbial strain;
b. perturbing the genome of the parental lineage microbial strain to add one or more of the identified genetic variations present in the production microbial strain, or perturbing the genome of the production microbial strain to remove one or more of the identified genetic variations not present in the parental lineage microbial strain, to create an initial library of microbial strains, wherein each strain in the initial library comprises a genetic variation from the plurality of identified genetic variations between the parental lineage microbial strain and the production microbial strain, and wherein at least one of the strains of the initial library comprises a genetic variation that does not have a known enzymatic or regulatory function;
c. screening and selecting individual strains of the initial library for phenotypic performance improvements over a reference microbial strain, thereby identifying genetic variations that confer phenotypic performance improvements;
d. providing a subsequent plurality of microbes that each comprise a combination of genetic variations from the genetic variations present in at least two individual microbial strains screened in the preceding step, to thereby create a subsequent library of microbial strains;
e. screening and selecting individual strains of the subsequent library for phenotypic performance improvements over the reference microbial strain, thereby identifying combinations of genetic variation that confer additional phenotypic performance improvements; and
f. repeating steps d)-e) one or more times, in a linear or non-linear fashion, until a microbial strain exhibits a desired level of improved phenotypic performance compared to the phenotypic performance of the production microbial strain, wherein each subsequent iteration creates a new library of microbial strains, where each strain in the new library comprises genetic variations that are a combination of genetic variations selected from amongst at least two individual microbial strains of a preceding library; and
wherein the method enables analyzing genome-wide combinatorial effects of genetic variations across multiple disparate genomic regions, including uncharacterized genes and/or genes of no known function.
US Pat. No. 10,457,938

TTV MIRNA SEQUENCES AS AN EARLY MARKER FOR THE FUTURE DEVELOPMENT OF CANCER AND AS A TARGET FOR CANCER TREATMENT AND PREVENTION

DEUTSCHES KREBSFORSCHUNGS...

1. A vector comprising a TTV nucleic acid operatively linked to a promoter, wherein the TTV nucleic acid consists of a nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-4, 12, and 38-55.
US Pat. No. 10,456,400

AZA-ELLIPTICINE ANALOGS, METHODS OF SYNTHESIS AND METHODS OF TREATMENT

MUSC Foundation for Resea...

1. A compound, wherein the compound is:6H-indolo[2,3-b][1,5]naphthyridine;
6-propyl-6H-indolo[2,3-b][1,5]naphthyridine;
10-propyl-10H-indolo[2,3-b][1,7]naphthyridine;
9-methyl-6-propyl-6H-indolo[2,3-b][1,5]naphthyridine;
7-methyl-10-propyl-10H-indolo[2,3-b][1,7]naphthyridine;
9-methoxy-6-propyl-6H-indolo[2,3-b][1,5]naphthyridine;
9,11-dimethyl-6-propyl-6H-indolo[2,3-b][1,5]naphthyridine;
9-chloro-6-propyl-6H-indolo[2,3-b][1,5]naphthyridine;
7-chloro-10-propyl-10H-indolo[2,3-b][1,7]naphthyridine;
9-methoxy-6H-indolo[2,3-b][1,5]naphthyridine;
7-methoxy-10H-indolo[2,3-b][1,7]naphthyridine;
6H-indolo[2,3-b][1,5]naphthyridin-9-ol;
7-methoxy-6H-indolo[2,3-b][1,5]naphthyridine;
7-methoxy-10-propyl-10H-indolo[2,3-b][1,7]naphthyridine;
9-methyl-6H-indolo[2,3-b][1,5]naphthyridine;
11-butyl-9-methoxy-6H-indolo[2,3-b][1,5]naphthyridine;
6-acetyl-6H-indolo[2,3-b][1,5]naphthyridin-9-yl acetate; or
9-(trifluoromethoxy)-6H-indolo[2,3-b][1,5]naphthyridine,or a pharmaceutically acceptable salt or tautomer thereof.
US Pat. No. 10,461,269

CROSSLINKABLE, /POLYMERIZABLE AND COMBINATIONS THEREOF CHARGE-TRANSPORTING MOLECULAR GLASS MIXTURES, LUMINESCENT MOLECULAR GLASS MIXTURES, OR COMBINATIONS THEREOF FOR ORGANIC LIGHT EMITTING DIODES AND OTHER ORGANIC ELECTRONICS AND PHOTONICS APPLICATIONS A

Molecular Glasses, Inc., ...

1. A method of manufacturing an organic device comprising:a) providing a substrate;
b) providing a first set of addressing electrodes over the substrate;
c) forming an organic hole-transporting layer over the first set of addressing electrodes and over the substrate;
d) forming an organic light-emitting layer over the organic hole-transporting layer, the light-emitting layer comprising a crosslinkable non-polymeric organic light-emitting layer, wherein the light-emitting layer is plasticized with a compatible low-Tg crosslinkable additive and has a glass transition temperature (Tg) below 80 degrees Celsius;
e) forming a dopant layer over the organic light-emitting layer and patterning such dopant layer to form color pixels, said color pixels comprising color subpixels wherein the colored subpixels are formed by diffusing the patterned dopant layer into the organic light-emitting layer by thermal annealing at a temperature below 80 degrees Celsius without a solvent;
f) after all the color subpixels are formed, subjecting the organic light-emitting layer to actinic energy to crosslink the low-Tg crosslinkable additive organic light-emitting layer, and increase the thermal properties of the organic light-emitting layer;
g) forming an organic electron-transporting layer over the doped organic light-emitting layer; and
h) forming a second set of addressing electrodes over the organic electron-transporting layer so that the color subpixels can be individually addressed.
US Pat. No. 10,457,941

METHODS AND COMPOSITIONS TO TREAT LIVER DISEASES AND CONDITIONS

Asociacion Centro de Inve...

1. A method of increasing glycine N-methyltransferase (GNMT) enzyme activity in a cell, the method comprising contacting a cell with an miRNA-inhibitor compound that inhibits at least one of miRNA-873-5p and miRNA-518d-5p in an amount effective to increase GNMT enzyme activity in the cell, wherein the increase in GNMT enzyme activity reduces DNA hypermethylation in the cell.
US Pat. No. 10,457,948

BIOPHARMACEUTICAL PRODUCTION METHOD

University of Kent, Cant...

1. A method for the manufacture of a disulphide-requiring biopharmaceutical protein having an element of at least tertiary structure using wild type E. coli, the method comprising:a) culturing wild type E. coli transformed with a plasmid expressing the biopharmaceutical with an N-terminal TorA signal peptide;
b) inducing the E. coli to express the biopharmaceutical protein; and
c) obtaining the biopharmaceutical protein from a periplasmic fraction,wherein:the biopharmaceutical protein comprises no more than two disulphide bonds and has a molecular weight of less than 30 kDa, and
the element of at least tertiary structure is adopted in the cytoplasm of the wild type E. coli.
US Pat. No. 10,456,426

EGG CHALAZA HYDROLYSATE, METHOD FOR PREPARING THE SAME AND USAGE OF THE SAME

National Taiwan Universit...

1. A method for preparing an egg chalaza hydrolysate comprising the steps of:step 1: defrosting an egg chalaza and washing with distilled deionized water for removal of impurities; taking a first product at a lower layer after centrifugation;
step 2: heating the first product at 95° C. for 10-30 minutes and cooling down; then adding distilled deionized water to get a homogeneous solution of the egg chalaza;
step 3: mixing 100-200 g homogeneous solution of the egg chalaza with a hydrolase at a ratio of 100:1-500:1 (w/w) and getting a first hydrolysate solution after reacting a period of time;
step 4: heating the first hydrolysate solution at 95° C. for 10-30 minutes and cooling down; then taking a second hydrolysate solution at an upper layer after centrifugation; and
step 5: filtering and lyophilizing the second hydrolysate solution to get the egg chalaza hydrolysate.
US Pat. No. 10,458,991

SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES

The Regents of the Univer...

1. A method for simultaneously fixing and staining cells, the method comprising:initially incubating the cells in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand;
exposing the incubating cells to ultraviolet (UV) light; and
continuing to incubate the cells in the solution after UV light exposure.
US Pat. No. 10,457,710

ANTIMICROBIAL PEPTIDES, THEIR VARIANTS AND USES

Chain Antimicrobials Oy, ...

1. An antimicrobial peptide, comprising any of the synthetically prepared peptides selected from the group consisting of SEQ ID NO: 32 having the amino acid peptide sequence defined by KWIVWRWRFKR, SEQ ID NO: 34 having the amino acid peptide sequence defined by RRIVKLRWFKR, SEQ ID NO: 35 having the amino acid peptide sequence defined by RRLIWRRFKWLR, SEQ ID NO: 36 having the amino acid peptide sequence defined by KRIVRWRTRKR, SEQ ID NO: 37 having the amino acid peptide sequence defined by KRIVRWRWRKR, and SEQ ID NO: 39 having the amino acid peptide sequence defined by WRILRWRKLKR, SEQ ID NO: 40 having the amino acid peptide sequence defined by WRIVRWRKLKR, and SEQ ID NO: 41 having the amino acid peptide sequence defined by WRIVQWRKLKR, wherein the peptides have an antimicrobial activity against the microbes selected from the group consisting of bacteria, fungi, and yeast.
US Pat. No. 10,457,716

PROTEIN FOLDING AND METHODS OF USING SAME

University of Notre Dame ...

1. A method for microscale production of a complex protein comprising at least a first protein of interest and a second protein of interest, wherein at least one protein of interest is a recombinant protein, comprising the steps of:diluting a denatured solubilized protein preparation comprising a first protein of interest to provide a diluted preparation;
dialyzing the diluted preparation at a temperature of between 4° C. and 32° C. for 1 to 3 hours to provide a first correctly folded first protein of interest preparation; and
adding a volume of a second protein of interest to the first protein of interest preparation to form a complex protein preparation comprising the complex protein;
adding the complex protein preparation to a purification reagent, the purification reagent capable of capturing the complex protein; and
obtaining the complex protein,wherein the complex protein has a biologically active folded protein structure, said method is completed in less than 24 hours,at least one protein of interest comprises ?2-microglobulin (?2m), a class I major histocompatibility complex protein heavy chain (MHC-HC), or a class I MHC binding molecule, andwherein each preparation has a final volume of less than 1 milliliter.
US Pat. No. 10,457,972

MASS SPECTROMETRIC DETERMINATION OF MICROBIAL RESISTANCES

1. A method of analyzing the resistance or susceptibility of microbes from a sample under investigation to an antibiotic, the method comprising:providing a synthetic growth medium which contains proteinogenic amino acids, wherein at least one of the amino acids is isotopically labeled, and wherein all of the isotopically labeled amino acids are labeled with isotopes from the group consisting of carbon, nitrogen, oxygen and sulfur and have the same integer mass difference ?m in relation to corresponding unlabeled amino acids;
cultivating said microbes in a first culture using the synthetic growth medium with the addition of the antibiotic;
cultivating said microbes in a second culture using the synthetic growth medium without the addition of said antibiotic; and
acquiring mass spectra of the microbes from the first and second cultures and comparing them to each other to determine an extent of a mass shift by said integer mass difference in the spectrum of the first culture.
US Pat. No. 10,456,953

DEVICE AND METHOD FOR CYCLE- AND COST-OPTIMIZED THERMAL TRANSFORMATION OF HOSE BLANKS

1. Method for the thermal reshaping of hose blanks consisting of elastic raw hose material, wherein the hose blank is located in a hollow, single- or multi-part molding tool during the reshaping, wherein the inner side of the hollow mold corresponds as a negative to the shape that is to be impressed upon the hose blank, characterized in that the tempering of the molding tool that is necessary for reshaping occurs by means of tempering elements with half or partial shells which close form-fittingly over the mold, and the inner sides of said shells that face the molding tool are congruent with the outer side of said molding tool, wherein no tempering device, no ducts or other hollow spaces for circulating a tempering medium at all are integrated into the molding tool itself, and wherein the temperature of each tempering element is kept constant during the process, while, to modify the temperature of the molding tool, a different tempering element with a different constant temperature is positioned against the molding tool.
US Pat. No. 10,457,729

COMPOSITIONS AND METHODS FOR TREATING CANCER

The Trustees of the Unive...

1. An isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the isolated nucleic acid sequence comprises a nucleic acid sequence encoding an ?-folate receptor (FR?) antibody comprising the amino acid sequence of SEQ ID NO: 23.
US Pat. No. 10,457,985

METHODS FOR INDEXING SAMPLES AND SEQUENCING MULTIPLE POLYNUCLEOTIDE TEMPLATES

Illumina Cambridge Limite...

1. A method for sequencing nucleic acid sequences and identifying subsets of nucleic acid sequences, each subset of nucleic acid sequences isolated from a different source, the method comprising the steps of:(a) providing at least two different samples of randomly fragmented double stranded nucleic acid targets, wherein each of the randomly fragmented double stranded nucleic acid targets is isolated from a different source;
(b) ligating a sample specific tagged adaptor to each end of each target fragment of each sample to generate adaptor-target-adaptors, wherein the tagged adaptor comprises at least one region of single stranded nucleic acid and a region of double stranded nucleic acid comprising a sample specific tag sequence that differentiates adaptor-target-adaptors originating from different samples, and wherein the sample specific tag sequence is attached directly to the target fragment in each adaptor-target-adaptor with no intervening nucleotides;
(c) amplifying the adaptor-target-adaptors of each sample with a pair of amplification primers complementary to the sample specific tag sequence to generate amplified adaptor-target-adaptors from each sample;
(d) pooling the amplified adaptor-target-adaptors of the at least two different samples;
(e) immobilizing the pooled adaptor-target-adaptors on a surface;
(f) sequencing the immobilized adaptor-target-adaptors on the surface to determine a sequence read of each immobilised adaptor-target-adaptor and identify the sample specific tag sequence of each immobilised adaptor-target-adaptor, thereby determining nucleic acid sequences of the immobilized adaptor-target-adaptors and identifying each of the immobilized adaptor-target-adaptors as a member of a subset of nucleic acid sequences.
US Pat. No. 10,457,732

BISPECIFIC BINDING PROTEINS AND USES THEREOF

MEDIMMUNE, LLC, Gaithers...

1. A bispecific binding protein that binds to PD-1 and CTLA-4 comprising a first heavy chain comprising the amino acid sequence of SEQ ID NO: 9, a first light chain comprising the amino acid sequence of SEQ ID NO: 7, a second heavy chain comprising the amino acid sequence of SEQ ID NO: 12, and a second light chain comprising the amino acid sequence of SEQ ID NO: 4.
US Pat. No. 10,457,988

MIRNAS AS DIAGNOSTIC MARKERS

Siemens Aktiengesellschaf...

1. A pharmaceutical composition containing an isolated nucleic acid molecule consisting of SEQ ID NO:270, wherein at least one nucleotide of the isolated nucleic acid molecule is a modified nucleotide or nucleotide analog.
US Pat. No. 10,457,738

STIMULATION VIA TLR4/MD-2 TO REVERSE TYPE 1 DIABETES

University of Cincinnati,...

1. A method of treating Type I diabetes in a subject, comprising administering an agonistic monoclonal antibody to Toll-Like Receptor 4 (TLR4).
US Pat. No. 10,457,994

4-MIRNA SIGNATURE FOR PREDICTING CLEAR CELL RENAL CELL CARCINOMA METASTASIS AND PROGNOSIS

CITY OF HOPE, Duarte, CA...

1. A method for predicting existence of or risk for developing metastasis in a renal cell carcinoma comprising:detecting a test expression level of a set of one or more miRNAs of a renal cell carcinoma-specific expression signature comprising miR-10b, miR-139-5p, miR-130b, and miR-199b-5p in a biological sample from a subject having a renal cell cancer;
assigning a risk score to the test expression level, wherein the risk score is calculated by a formula:
Risk score=?1.275564×XmiR-10b+2.106701×XmiR-130b?2.278192×XmiR-139-5p+1.101139×XmiR-199b-5p; and
predicting the existence of or a high risk for developing metastasis when the test expression level is assigned a high risk score, predicting a low risk for developing metastasis when the test expression level is assigned a low risk score.
US Pat. No. 10,457,739

ANTI-CEACAM5 ANTIBODIES AND USES THEREOF

SANOFI, Paris (FR)

1. An isolated nucleic acid comprising a sequence encoding an antibody or antigen binding fragment thereof that binds to human CEACAM5 protein, wherein said antibody or antigen binding fragment thereof comprises a CDR1-H comprising an amino acid sequence of SEQ ID NO:7, a CDR2-H comprising an amino acid sequence of SEQ ID NO:8, a CDR3-H comprising an amino acid sequence of SEQ ID NO:9, a CDR1-L comprising an amino acid sequence of SEQ ID NO:10, a CDR2-L comprising an amino acid sequence of NTR or an amino acid sequence of NTK, and a CDR3-L comprising an amino acid sequence of SEQ ID NO:12.
US Pat. No. 10,458,007

QUENCH AND TEMPER CORROSION RESISTANT STEEL ALLOY

CRS HOLDINGS, INC., Wilm...


and the balance is iron and impurities wherein phosphorus is restricted to not more than about 0.005%, sulfur is restricted to not more than about 0.001%, and nitrogen is restricted to not more than about 0.03%.
US Pat. No. 10,457,752

SILANE FUNCTIONALIZED POLY (FARNESENE) AND RUBBER COMPOUND COMPRISING THE SAME

FINA TECHNOLOGY, INC., H...

1. A curable rubber composition comprising:a high molecular weight diene elastomer having a number average molecular weight Mn above 80,000 Da;
a silica;
a carbon black; and
a farnesene polymer produced via living anionic polymerization of at least one farnesene monomer, the farnesene polymer having at least one terminal end modified with at least one silane group, wherein the farnesene polymer has a number average molecular weight of 1,000 g/mol to 100,000 g/mol, a silane functionality of two or less and a glass transition temperature of equal to or less than ?40° C., wherein the farnesene polymer is produced by process i) or process ii):
i) a process comprising polymerizing farnesene monomers to obtain a living farnesene polymer having one or more living ends and capping the living ends of the living farnesene polymer with a silane ester;
ii) a process comprising polymerizing farnesene monomers to obtain a living farnesene polymer, modifying at least one terminal end of the living farnesene polymer by reacting the living farnesene polymer with an alkylene oxide followed by a proton source to produce a hydroxyl-terminated farnesene polymer having at least one terminal hydroxyl group, and modifying at least one terminal hydroxyl group of the hydroxyl-terminated farnesene polymer by converting the at least one terminal hydroxyl group to a silane group.
US Pat. No. 10,460,827

IDENTIFICATION OF THERAPEUTIC TARGETS FOR COMPUTER-BASED DESIGN OF DRUGS AGAINST BACTERIA CONTAINING THE PILT PROTEIN

EMPRESA BRASILEIRA DE PES...

1. A method for identifying drug candidates that inhibit motility of PilT-expressing Xylella fastidiosa, comprising:(a) selecting at least one interface-forming residue from a PilT protein from a PilT-expressing Xylella fastidiosa as a therapeutic target site, wherein said at least one interface-forming residue is selected from the group consisting of residue D184, E89, K187, E258, E74, K235, K249, R35, R90, D33, E248, R36, H152, E336, K58, R212, R335 and E65 from Xylella fastidiosa PilT; and
(b) identifying at least one drug candidate predicted to bind to said therapeutic target site, wherein said identifying comprises one or more of de novo drug design and virtual screening.
US Pat. No. 10,456,478

DUALLY DERIVATIZED CHITOSAN NANOPARTICLES AND METHODS OF MAKING AND USING THE SAME FOR GENE TRANSFER IN VIVO

1. A method of delivering a therapeutic nucleic acid to a subject in need thereof comprising administering to the subject a therapeutically effective amount of a dually derivatized (DD) chitosan nucleic acid polyplex, wherein said DD chitosan nucleic acid polyplex comprises a chitosan-derivative nanoparticle comprising chitosan coupled with gluconic acid and arginine and said therapeutic nucleic acid.
US Pat. No. 10,457,764

MODIFIED HYDROCARBON RESIN AND HOT MELT ADHESIVE COMPOSITION

ZEON CORPORATION, Chiyod...

1. A modified hydrocarbon resin obtained by hydrogenating a hydrocarbon resin comprising:a 1,3-pentadiene monomeric unit of 20 mass % to 70 mass %,
a C4-6 alicyclic monoolefin monomeric unit of 10 mass % to 35 mass %,
a C4-8 acyclic monoolefin monomeric unit of 5 mass % to 30 mass %,
an alicyclic diolefin monomeric unit of 0 mass % to 1 mass %, and
an aromatic monoolefin monomeric unit of 0 mass % to 40 mass %,
the modified hydrocarbon resin being characterized in that:a degree of hydrogenation of the olefins is within a range of 30% to 80%;a degree of hydrogenation of the aromatic rings, if an aromatic monomeric unit is included, is within a range of 5% to 20%;
a weight average molecular weight (Mw) is within a range of 1,000 to 4,000;
a Z-average molecular weight (Mz) is within a range of 2,500 to 10,000;
a ratio (Mz/Mw) of the Z-average molecular weight to the weight-average molecular weight is within a range of 1.5 to 2.5;
a Gardner color scale of a toluene solution of 50 mass % is 2 or lower; and
a difference between pre-hydrogenation and post-hydrogenation mixed aniline point (MMAP) is 5° C. or less.
US Pat. No. 10,461,358

RECHARGEABLE LITHIUM BATTERY

Samsung SDI Co., Ltd., Y...

1. A rechargeable lithium battery comprising:a positive electrode;
a negative electrode;
a separator between the positive electrode and the negative electrode;
a polymer layer on the separator, the polymer layer comprising polyvinylidene fluoride, the polyvinylidene fluoride loaded at a loading level of 1.5 to 2.5 g/m2; and
an electrolyte impregnating the separator, the electrolyte comprising a carbonate-based solvent and an alkyl propionate in a volume ratio of 4:6 to 5:5, the alkyl propionate comprising a compound selected from the group consisting of methyl propionate, ethyl propionate, and a combination thereof,
wherein the carbonate-based solvent comprises a cyclic carbonate-based solvent and a linear carbonate-based solvent in a volume ratio of 4:1 to 3:2, and the linear carbonate-based solvent is one or more selected from the group consisting of dimethyl carbonate, diethyl carbonate, dipropyl carbonate, methylpropyl carbonate, ethylpropyl carbonate, methylethyl carbonate, ethylmethyl carbonate and butylene carbonate.
US Pat. No. 10,457,773

METHOD OF PREPARING POLYALKYLENE CARBONATE RESIN

LG Chem, Ltd., Seoul (KR...

1. A method of preparing a polyalkylene carbonate resin, the method comprising the sequential steps of:preparing a reaction mixture comprising polyalkylene carbonate, a catalyst residue, unreacted residual monomers, a chlorinated solvent, and alkylene carbonate-comprising by-products by polymerizing monomers comprising carbon dioxide and an epoxide compound in the presence of the catalyst and the chlorinated solvent;
recovering residual monomers from the reaction mixture;
removing the by-products from the reaction mixture, from which the residual monomers have been removed, by using 200 parts by weight to 1000 parts by weight of water with respect to 100 parts by weight of the monomers;
removing the catalyst residue from the reaction mixture, from which the residual monomers and the by-products have been removed, by using a filter having a pore size of less than 50 um; and
removing the chlorinated solvent from the reaction mixture, from which the residual monomers and the catalyst residue have been removed.
US Pat. No. 10,457,022

SINGLE- OR MULTILAYER FILM COMPRISING BONDED POLYVINYL ALCOHOL

1. A single- or multilayer polymeric film, comprisingat least one (co)polyamide and
one or more water soluble polyvinyl alcohol (s) (PVAs),
wherein said film additionally comprises a bonded polyvinyl alcohol (PVAB), wherein said PVAB
i. is insoluble in water in a range of 18-100° C.,
ii. is soluble in C1 to C3 carboxylic acids,
iii. is capable of reaction with iodine, thereby producing a blue-colored product, and
iv. is capable of reaction with a primary amine, thereby becoming water-soluble,
wherein a ratio CB/CSis at least 0.05, wherein CB is a content of PVAB in said film and CS is a content of PVAS in the film, and
wherein the film is produced by a process comprising
one or more stages including thermal treatment and/or thermal-oxidative treatment of a PVA raw material with participation of elemental oxygen, resulting in at least one pelletized raw polymeric material comprising said PVAS, and
melt (co)extrusion of said film,
wherein said at least one pelletized raw polymeric material used for the melt (co)extrusion comprises at least one of two components, including
a. said PVAB in such concentration that the ratio CB/CS?0.05, and
b. said PVAS comprising
a carbonyl-modified PVA (PVACO), the PVACO being a product of the thermal treatment and/or thermal-oxidative treatment of the PVA raw material, a 4% aqueous solution of said PVACO mixed with an excess of 2,4-dinitrophenylhydrazine having an optical density not less than 0.1 at the wavelength of 490 nm.
US Pat. No. 10,458,068

METHOD FOR PRODUCING PAPER

KEMIRA OYJ, Helsinki (FI...

1. A method for manufacturing paper, comprising:producing a pulp slurry;
forming a paper sheet from the pulp slurry including cellulose fibers;
adding at least one aldehyde functionalized polymer to said pulp slurry or to the formed paper sheet, wherein the at least one aldehyde functionalized polymer covalently bonds to the cellulose fibers; and
adding a water soluble acid having a relative acidity (RA) value greater than 0.05 g/kg dry paper onto the formed paper sheet.

US Pat. No. 10,462,770

METHOD FOR TRANSMITTING UPLINK CONTROL INFORMATION, USER EQUIPMENT AND BASE STATION

Huawei Technologies Co., ...

1. A method for transmitting uplink control information, the method comprising:receiving a physical downlink control channel from a base station, wherein the physical downlink control channel includes indication information used to indicate a physical uplink control channel resource used to transmit uplink control information;
determining, according to the uplink control information, a resource group from semi-statically configured resource groups including a first resource group and a second resource group, wherein when the uplink control information includes periodic channel state information and hybrid automatic repeat request acknowledgment information, the determined resource group is the first resource group, and wherein when the uplink control information includes hybrid automatic repeat request acknowledgment information and a scheduling request but without periodic channel state information, the determined resource group is the second resource group, wherein a maximum number of information bits supported by physical uplink control channels corresponding to resources comprised in the first resource group is greater than a maximum number of information bits supported by physical uplink control channels corresponding to resources comprised in the second resource group;
determining, according to the indication information, the physical uplink control channel resource in the determined resource group; and
sending the uplink control information to the base station over a physical uplink control channel corresponding to the physical uplink control channel resource.

US Pat. No. 10,462,768

RECEPTION APPARATUS, RECEPTION METHOD, TRANSMISSION APPARATUS, AND TRANSMISSION METHOD

SONY CORPORATION, Tokyo ...

1. A reception apparatus, comprising:a receiver configured to receive a digital broadcast signal via a first communication path using an IP (Internet Protocol) transmission system;
a communication interface configured to access a server via a second communication path different from the first communication path; and
circuitry coupled to the receiver and the communication interface, the circuitry configured to:
receive first signaling information for acquiring broadcast content transmitted by the digital broadcast signal;
acquire second signaling information relating to characteristics of at least one service included in the broadcast content on the basis of the first signaling information, the second signaling information received from the server via the communication interface;
acquire, on the basis of pointer information included in the first signaling information, channel selection information included in the second signaling information transmitted in a second layer, the second layer being a different layer from a first layer in the hierarchy of the protocol of the IP transmission system, the first signaling information being transmitted in the first layer; and
control, on the basis of the second signaling information, operations of respective units that perform channel selection processing, wherein
the pointer information is information for accessing the channel selection information in a particular service in accordance with a channel selection operation, and
the pointer information includes a first identifier assigned to each broadcaster as a unique value, a second identifier assigned to each stream as a unique value, and a third identifier assigned to each service as a unique value.

US Pat. No. 10,462,762

METHODS FOR SYNCHRONIZING MULTIPLE DEVICES AND DETERMINING LOCATION BASED ON THE SYNCHRONIZED DEVICES

Wiser Systems, Inc., Ral...

1. A method for synchronizing multiple transceivers to a single master clock, the method comprising:receiving a message broadcast from a master device at at least one known device, the broadcasted message including a departure time in master clock time units (TDEPART-MD);
recording a time of arrival at the at least one known device in the at least one known device time units (TARRIVAL-KD);
repeatedly receiving messages including an associated departure time in master clock time units (TDEPART-MD) and recording associated times of arrival at the at least one known device in the at least one known device time units (TARRIVAL-KD) to provide a plurality of departure time, arrival time pairs (TDEPART-MD, TARRIVAL-KD); and
translating a time of any target event from known device time units to master device time units by applying a fit curve to the departure time, arrival time pairs and applying an offset of a known travel time for a radio frequency signal from the master device to the at least one known device in master clock time units (TTRAVEL-MD).

US Pat. No. 10,462,756

METHOD AND APPARATUS FOR CONTROLLING TRANSMISSION POWER OF TERMINAL IN MOBILE COMMUNICATION SYSTEM

Samsung Electronics Co., ...

1. A method for transmitting data by a terminal in a mobile communication system, the method comprising:receiving, from a base station, first control information in a first time point, wherein the first control information instructs the terminal to transmit a first uplink data in a fourth time point;
receiving, from the base station, second control information in a second time point after the first time point, wherein the second control information instructs the terminal to the terminal to transmit a second uplink data in a third time point before the fourth time point;
transmitting, to the base station, the second uplink data in the third time point based on the second control information; and
determining a transmission power of the first uplink data corresponding to the first control information based on a transmission power of the second uplink data.

US Pat. No. 10,462,751

METHOD AND APPARATUS FOR COORDINATING RESOURCES BETWEEN DIFFERENT TYPES OF COMMUNICATIONS

Telefonaktiebolaget LM Er...

1. A method for use in a terminal device for coordinating resources between two different types of communications, comprising:receiving resource allocation information indicating an allocation of resource units for the two different types of communications;
determining, based on the resource allocation information, whether a collision will occur between the two different types of communications on a specific resource unit, wherein the two different types of communications comprises device to device communications and cellular communications;
in response to determining that a collision will occur between the two different types of communications on the specific resource unit, adjusting one of the two different types of communications on the specific resource unit to avoid the collision, wherein adjusting of the one of the two different types of communications on the specific resource unit comprises reducing transmission power of the one of the two different types of communications to minimize interference to the other of the two different types of communications; and
resuming the adjusted one of the two different types of communications on a next non-colliding resource unit allocated for the adjusted one of the two different types of communications at a normal transmission power level,
wherein the resource allocation information comprises information regarding a pre-set uplink-downlink configuration and one or more resource units allocated for the device to device communications and further comprises information regarding a subset of the one or more resource units allocated for the device to device communications and cellular transmissions.

US Pat. No. 10,462,749

METHOD AND APPARATUS FOR CONTROLLING UPLINK POWER IN WIRELESS COMMUNICATION SYSTEM

LG Electronics Inc., Seo...

1. A method for operating a user equipment (UE) in a wireless communication system, the method comprising:determining whether a second uplink (UL) transmission to a second eNodeB (eNB) cannot occur in a second subframe, wherein the second subframe overlaps with a first subframe in time;
when it is determined that the second UL transmission to the second eNB cannot occur in the second subframe, determining a transmission power for a first UL transmission to a first eNB in the first subframe within a power which is used in subframes where only the first UL transmission to the first eNB can occur;
when it is determined that the second UL transmission to the second eNB can occur in the second subframe, determining the transmission power for the first UL transmission to the first eNB in the first subframe within a power which is used in subframes where both the first UL transmission to the first eNB and the second UL transmission to the second eNB can occur; and
performing the first UL transmission to the first eNB in the first subframe based on the transmission power,
wherein the UE is connected to both the first eNB and the second eNB in dual connectivity.

US Pat. No. 10,462,746

SETTING INFORMATION CONFIGURATION METHOD, TERMINAL, AND SERVER

HUAWEI TECHNOLOGIES CO., ...

1. A setting information configuration method, implemented by a terminal, the setting information configuration method comprising:obtaining, by the terminal, an analysis result, wherein the analysis result is obtained after local setting information of the terminal is analyzed according to an improper setting information set, wherein the analysis result comprises at least improper setting information input by a user and a setting suggestion, wherein the improper setting information causes greater power consumption to the terminal, and wherein the setting suggestion comprises lowering a screen luminance value when the improper setting information comprises that the screen luminance value is greater than a first preset threshold;
displaying, by the terminal, the improper setting information and the setting suggestion;
receiving, by the terminal, a setting instruction from the user according to the displayed improper setting information and the setting suggestion; and
configuring, by the terminal, the local setting information according to the setting instruction.

US Pat. No. 10,462,731

SYSTEM INFORMATION BLOCK TRANSMISSION

QUALCOMM Incorporated, S...

1. A method for wireless communication, comprising:receiving synchronization information from a base station over a first frequency range;
identifying a second frequency range based at least in part on an offset of the second frequency range from the first frequency range used for the synchronization information;
receiving control information from the base station within the second frequency range;
receiving a reference signal within the second frequency range; and
decoding the control information based at least in part on the reference signal.

US Pat. No. 10,462,730

EXTENDED SYSTEM INFORMATION DISTRIBUTION MECHANISMS

Telefonaktiebolaget LM Er...

1. A method implemented by a network node in a wireless communication network of transmitting system information to a plurality of wireless terminals, the method comprising:transmitting a first group of system information blocks (SIBs) via a first physical channel, the first physical channel configured to be read by a first group of wireless terminals and also by a different, second group of wireless terminals;
transmitting a second group of additional SIBs via a different, second physical channel, the second physical channel configured to be read by only one of the first and second group of wireless terminals;
wherein:
the first physical channel is a Primary Common Control Physical Channel (P CCPCH);
the second physical channel is one of a Secondary Common Control Physical Channel (S-CCPCH) and a High Speed Physical Downlink Shared Channel (HS PDSCH); and
transmitting the second group of additional SIBs via the second physical channel comprises:
transmitting, via the second physical channel according to a first repetition period, one or more first SIBs that only include static system information; and
transmitting, via the second physical channel according to a different, second repetition period, one or more second SIBs that only include dynamic system information.

US Pat. No. 10,462,727

MEDIA DISTRIBUTION VIA A SCALABLE AD HOC GEOGRAPHIC PROTOCOL

1. A method comprising:receiving, via an ad hoc network, a message at a device, the message comprising a media segment and an indication of a geocast region of intended reception;
determining a first distance from the device to a point in the intended reception area of the message;
determining a plurality of distances between the point and each of a plurality of sources from which the device previously had received the message; and
retransmitting the message to another device via the ad hoc network based on the first distance being less than each of the plurality of distances.

US Pat. No. 10,462,721

METHOD AND APPARATUS FOR CELL RESELECTION IN MOBILE COMMUNICATIONS

MEDIATEK SINGAPORE PTE. L...

1. A method, comprising:receiving, by a processor of an apparatus, a redirection frequency;
receiving, by the processor, a dedicated frequency offset value corresponding to the redirection frequency;
determining, by the processor, a cell-ranking criterion for a serving cell according to the dedicated frequency offset value by:
counting, based on a valid timer value for the dedicated frequency offset value, a time period in applying the dedicated frequency offset value in the determining of the cell-ranking criterion;
measuring a reference symbol received power (RSRP) of the serving cell;
measuring a RSRP of a neighboring cell at a the redirection frequency;
and comparing results of the measuring of the RSRP of the serving cell and the measuring of the RSRP of the neighboring cell; and
performing, by the processor, cell reselection to the neighboring cell at the redirection frequency from the serving cell based on a result of the comparing.

US Pat. No. 10,462,714

METHOD AND APPARATUS FOR MOBILITY MANAGEMENT

Samsung Electronics Co., ...

1. A method to operate a terminal in a wireless communication network, the method comprising:transmitting a connection request message to a target base station, wherein the connection request message is a radio resource control (RRC) connection reestablishment request message;
receiving, from the target base station, a terminal information request message including information indicating that radio link failure information is requested; and
transmitting, to the target base station, a terminal information response message including information on a source base station where radio link failure is detected, in response to the terminal information request message, wherein the information on the source base station comprises a tracking area code (TAC).

US Pat. No. 10,462,711

CONTROLLING TCP DATA TRANSMISSION

Futurewei Technologies, I...

1. A method, comprising:detecting, by a mobile device, a handover for the mobile device;
receiving, by the mobile device via a Transmission Control Protocol (TCP) session between the mobile device and a remote TCP server, a sequentially first TCP data packet after the handover;
generating, by the mobile device, a first acknowledgement (ACK) associated with the sequentially first TCP data packet, wherein the first ACK comprises a first Selective ACK (SACK) option that causes the remote TCP server to enter a slow speed period that exists between the handover and a slow-start process, a TCP congestion window is set in minimum during the slow speed period, and a speed of sending TCP data packets is limited by the TCP congestion window that is kept in minimum;
determining, by the mobile device, a gap between data in the sequentially first TCP data packet and data received before the handover, wherein the gap is determined when a most right edge in the first SACK option is larger than a cumulative ACK sequence number of the first ACK;
removing, by the mobile device in response to the gap between the data in the sequentially first TCP data packet and the data received before the handover, the first SACK option from the first ACK; and
sending, by the mobile device, the first ACK in which the first SACK option is removed to the remote TCP server via the TCP session, wherein the first SACK option has one or more boundary items, each including a left edge and a right edge.

US Pat. No. 10,462,703

VEHICLE-TO-X COMMUNICATION DEVICE

1. A vehicle-to-X communication device, comprising:a first processing unit for the processing of received vehicle-to-X messages; and
a second processing unit,
wherein the second processing unit is configured to send vehicle-to-X messages during a starting sequence of the first processing unit, and
wherein the second processing unit has a shorter start time compared with the first processing unit.

US Pat. No. 10,462,695

DEVICE AND METHOD FOR HANDLING MEASUREMENT CONFIGURATION IN DUAL CONNECTIVITY

HTC Corporation, Taoyuan...

1. A communication device for handling measurement configuration in dual connectivity (DC), comprising:at least one storage device; and
at least one processing circuit, coupled to the at least one storage device, wherein the at least one storage device stores, and the at least one processing circuit is configured to execute instructions of:
establishing a first signaling radio bearer (SRB) for communicating with a first base station (BS);
being configured a first measurement configuration by the first BS;
transmitting a first measurement report associated to the first measurement configuration on the first SRB, to the first BS;
receiving a first radio resource control (RRC) message on the first SRB from the first BS, wherein the first RRC message configures a second BS as a secondary node (SN) such that the communication device is in a DC with the first BS and the second BS;
establishing a second SRB for communicating with the second BS, while the communication device is in the DC;
being configured a second measurement configuration by the second BS;
transmitting a second measurement report associated to the second measurement configuration on the second SRB to the second BS, while the communication device is in the DC;
detecting a first failure on a first connection with the first BS; and
releasing the second measurement configuration in response to the first failure on the first connection with the first BS.

US Pat. No. 10,462,690

RLC STATUS REPORTING FOR EIGHT-CARRIER HSDPA

Telefonaktiebolaget LM Er...

1. A method performed in a mobile terminal for signaling radio link control status reports to a wireless network node, the method comprising:calculating a throughput estimate for data transmissions to the mobile terminal;
receiving a threshold value from the wireless network node;
determining, based on the throughput estimate, a single rate at which radio link control status reports are to be sent from the mobile terminal,
wherein the single rate indicates a time between radio link control status reports or a frequency of reporting the radio link control status reports;
wherein the determining the single rate comprises selecting the single rate by selecting one of a plurality of values for a prohibit timer, the plurality of values comprising a first value for selection when the throughput estimate is above the threshold value and a second value, different from the first value, for selection when the throughput estimate is below the threshold value; and
wherein the prohibit timer prohibits sending of all radio link control status reports for a certain amount of time; and
sending a plurality of radio link control status reports to the wireless network node at the determined single rate, wherein one or more of the plurality of radio link control status reports report at least one data transmission to the mobile terminal was defective, and one or more of the plurality of radio link control status reports report at least one data transmission to the mobile terminal was successfully received by the mobile terminal.