US Pat. No. 10,335,345

VIBRATION DEVICE USING SOUND PRESSURE, AND HUMAN BODY STIMULATION APPARATUS COMPRISING SAME

EVOSONIC CO., LTD., Wonj...

1. A vibration device for generating vibration using sound pressure, the vibration device comprising:a lower body being open at a top thereof, and defining an accommodation space therein;
a lower bracket being open at a top and a bottom thereof, and provided in the accommodation space of the lower body;
a magnetic body fixedly provided on a bottom surface of the lower body to generate a magnetic force;
a bobbin provided in the lower bracket to be located above the magnetic body;
a voice coil provided on an outer circumference of the bobbin to interact with the magnetic body;
a damper provided on an upper surface of the bobbin, coupled to an upper surface of an edge of the lower bracket, and vertically generating vibration by interaction between the magnetic body and the voice coil;
a connection member coupled at a lower end thereof to a central portion of the damper and a central portion of the upper surface of the bobbin, and coupled at an upper end thereof with a vibration probe for stimulating a human body, thus transmitting vibration from the damper to the vibration probe;
an upper body covering an open top of the lower body, the connection member being inserted into a center on an upper surface of the upper body; and
an upper bracket being open at a bottom thereof, and accommodated in an internal space of the upper body to be coupled with the lower bracket, the connection member being inserted into an upper surface of the upper bracket.

US Pat. No. 10,335,344

MASSAGE APPLIANCE, MANUFACTURING METHOD THEREOF, AND MANUFACTURING APPARATUS

TENGA CO., LTD., Tokyo (...

1. A manufacturing method of a massage appliance comprising:providing a motor, a vibrating piece configured to be driven by the motor, and a case configured to accommodate the motor and the vibrating piece and including a case opening at least in one place;
accommodating the motor and the vibrating piece in the case;
preparing a soft cover which includes a cover opening at a position corresponding to the case opening, the soft cover configured to surround an outer surface of the case;
coating the soft cover on the outer surface of the case to make the case opening communicate with the cover opening;
forming a space between the outer surface of the case and an inner surface of the soft cover by tightly fixing a peripheral edge of the cover opening over the entire peripheral of a peripheral edge of the case opening;
introducing a negative pressure into the space;
injecting a liquid resin as an undiluted solution of a soft resin into the space, the soft resin being interposed between the outer surface of the case and the soft cover, and being of a material which is more flexible than the soft cover, and being thicker than the soft cover; and
curing the liquid resin to become the soft resin.

US Pat. No. 10,335,340

MOBILE DENTAL INTELLIGENCE CENTER

Dr. Kevin T. Prince, Hon...

1. A portable dental and medical unit comprising:a wheelbase;
a plurality of 360 degree rotatable wheels extending from the wheelbase and configured to movably support the unit on an underlying support surface;
a central support beam extending upward from the wheelbase;
a rechargeable power supply positioned within a power supply compartment and a retractable wall plug mounted on the central support beam adjacent said wheelbase;
a cylindrical housing supported by the central support beam and spaced apart from the wheelbase, wherein the cylindrical housing is vertically adjustable with respect to the wheelbase by a unit height adjustor;
the cylindrical housing has a bottom and a top and comprises series of elements including:
a waste water reservoir with a reservoir drain positioned adjacent the bottom;
a clean water reservoir with a reservoir drain position adjacent the bottom;
a suction pump positioned adjacent said waste water reservoir or said clean water reservoir;
an air compressor positioned adjacent said waste water reservoir or said clean water reservoir;
a mouthwash reservoir positioned adjacent said suction pump;
a toothbrush rinser positioned adjacent said mouth wash reservoir;
a biofilm contamination sensor located near the waste water reservoir;
a water pump;
a unit control module; and
a unit supply platform positioned within a unit supply storage compartment adjacent the mouth wash reservoir, toothbrush rinser and unit control module and near a top of the cylindrical housing, wherein the unit supply platform includes a series of inter-unit supply line attachment ports and a series of USB ports;
a protrusion, including dual solar panels positioned on a surface thereof, extends upward from the top of the cylindrical housing and includes a foldable handle with slip-resistant grip mounted thereto and a 360 degree swivel digital display mounted thereto;
wiring and inter-unit supply lines and hoses extend through the central support beam and are configured to attach to at least one of the series of elements, the rechargeable power supply or an electric toothbrush, a computer monitor or an air-water syringe and connector;
wherein the 360 degree swivel digital display is configured to display information measured by one of said series of elements or an external health monitoring device including a digital blood pressure cuff, a digital thermometer, a digital pulse oximeter or a digital intra oral and extra oral camera connected to one of the series of USB ports.

US Pat. No. 10,335,338

APPARATUS FOR APPLYING MULTI-DIMENSIONAL TRACTION TO THE SPINAL COLUMN

Nichols Therapy Systems L...

1. A physical medicine table for treating a patient's spine comprising:a. a frame having a longitudinal axis and a transverse axis;
a plurality of support portions that are configured to receive a patient, wherein the plurality of support portions are attached to the frame and selectively spaced apart along the longitudinal axis of the frame;
c. wherein a first support portion comprises:
i. a first longitudinal movement subframe slidably mounted to the frame;
ii. a first lateral movement subframe slidably mounted to the first longitudinal movement subframe and configured to move in the transverse axis;
iii. a rotational adjustment subframe mounted to the first lateral movement subframe, the rotational adjustment subframe configured to selectively rotate;
d. a traction system comprising:
i. a first lateral actuator centrally mounted to the first longitudinal movement subframe and centrally disposed under the rotational adjustment subframe;
ii. wherein the traction system is configured to exert a first lateral force upon the first lateral movement subframe without rotating the first lateral movement subframe and without rotating the first support portion, wherein the first lateral force is perpendicular to the longitudinal axis of the frame, and the traction system is further configured to exert a longitudinal force upon at least one of the plurality of support portions; and
e. a control system that selectively controls the first lateral force and the longitudinal force exerted by the traction system.

US Pat. No. 10,335,336

INCUBATOR

Atom Medical Corporation,...

1. An incubator comprising:an incubator base that is provided on a main strut;
a bed base that is provided on the incubator base and on which a mattress is placed; and
a cassette tray accommodation space which is formed between the incubator base and the bed base, wherein the cassette tray accommodation space comprises at least three tray loading/unloading ports selected from: a front tray loading/unloading port, a rear tray loading/unloading port, a left tray loading/unloading port, and a right tray loading/unloading port.

US Pat. No. 10,335,333

MECHANICS OF THE BED SIDERAIL

LINET SPOL. S R.O., Slan...

1. A bed comprising:a frame,
a patient support connected to the frame,
at least two posts connected on one side of the bed to the frame of the bed,
at least one siderail with a frame,
a locking mechanism positioned between the two posts and at least one part of the frame of the siderail, and
a linkage for manipulation of the siderail with respect to the patient support, the linkage comprising a first arm and a second arm; the first arm having a first end connected in a rotating manner by a fixed pivot to the frame of the bed and a second end connected in a rotating manner to a center of the second arm; the second arm having a first end connected in a rotating manner by a sliding coupling to the frame of the bed and a second end connected in a rotating manner to the bed siderail.

US Pat. No. 10,335,332

TOP BAR ACCESSORY FOR WALKER

GANM, LLC, Paris, TN (US...

1. An accessory package for a walker, the accessory package comprising:a cross bar having opposite first and second ends; and
first and second pivot connections configured to connect to the respective first and second ends of the cross bar to the respective laterally opposite sides of a frame of the walker, each of the pivot connections comprising;
an eyelet portion adapted and configured to receive one of the first and second ends of the cross bar, the eyelet portion having a stem with a stem axis extending along a length of the stem; and
an upright piece adapted and configured to be removable attachable to the respective lateral opposite sides of the frame with mechanical fasteners, the upright piece having an outer shape formed to conform to a framework of the walker such that when the upright piece is removably connected to the framework of the walker with the mechanical fasteners, the upright piece is constrained from relative movement with the framework of the walker, the upright piece being adapted and configured to receive the stem and permit adjustment of the length of the stem received within the upright piece along the stem axis, the upright piece being adapted and configured to allow relative rotation of the stem within the upright piece about the stem axis thereby allowing pivoting of the upright piece about the stem axis;
further comprising a locking cap adapted and configured to be fitted to the respective first and second ends of the cross bar to secure the cross bar within the eyelet portion.

US Pat. No. 10,335,330

MOTOR-DRIVEN CHAIR STEERED BY SEAT ROTATION

TRAVELSYS4U LTD., Ramat ...

1. A motor-driven chair for propelling a user over an underlying surface, the chair comprising:(a) a seat element having support surfaces for supporting the user sitting in a seat-facing direction;
(b) a seat pole extending downwards from said seat element for supporting said seat element, said seat pole defining a vertical axis;
(c) a drive wheel rotatable about a horizontal axis of rotation so as to define a direction of forward motion perpendicular to said axis of rotation, said drive wheel being located beneath said seat element substantially on said vertical axis, said drive wheel being mechanically linked to said seat pole so as to maintain said direction of forward motion aligned with said seat-facing direction so that rotation of said seat element about said vertical axis causes a corresponding rotation of said direction of forward motion;
(d) a motor in driving connection to said drive wheel so as to drive said drive wheel to rotate about said horizontal axis of rotation, and thereby propel the chair in the seat-facing direction;
(e) a stabilizer assembly mechanically linked to said seat pole, said stabilizer assembly comprising a set of stabilizer wheels mounted on a support structure for supporting said seat pole in a vertical orientation, said stabilizer assembly allowing rotation of said seat pole about said vertical axis relative to said support structure; and
(f) a suspension arrangement associated with said seat pole, said drive wheel and said stabilizer assembly, said suspension arrangement being configured to distribute a load of the user sitting stably on said seat element so as to maintain a predefined range of proportions between a load supported by said drive wheel and a load supported by said stabilizer wheels.

US Pat. No. 10,335,326

SMART NURSING CONSUMABLE AND PHYSIOLOGICAL MONITORING DEVICE USING THE SAME

Sinopulsar Technology Inc...

1. A smart nursing consumable, comprising:an absorbent body, comprising a water-absorbing layer and a water draining layer disposed above the water-absorbing layer; and
a sensor module, disposed on the water draining layer and comprising a plurality of wires, a first porous sheet, a second porous sheet and a conductive pad, wherein the wires are disposed between the first porous sheet and the second porous sheet, the first porous sheet is disposed adjacent to the water-absorbing layer, and the conductive pad is connected to the wires through pores of the second porous sheet.

US Pat. No. 10,335,322

ADHESIVE SUPPORT DEVICES AND METHODS OF MAKING AND USING THEM

LightSide MD, LLC, Los A...

1. A method of making an adhesive support device having a three-dimensional shape, the method comprising:placing a planar sheet of material between a first tool and a second tool, wherein the sheet of material extends in a first plane and wherein the material has an elastic modulus of greater than 0.4 GPa;
stamping the planar sheet of material between the first tool and the second tool to deform a portion of the material so that it forms a cavity portion extending out of the first plane;
securing an adhesive substrate to a base region extending in the first plane wherein the base region is a portion of the planar sheet peripheral to the cavity portion; and
laser cutting one or more walls of the cavity portion using a laser that is oriented perpendicular to the first plane.

US Pat. No. 10,335,307

PENILE CONSTRICTION DEVICE

OVO JOINT VENTURE LLC, H...

1. A penile constriction device comprising:a ring-shaped body and an elongated head element having a length that is greater than its maximum width, wherein the head element extends lengthwise in a radial direction relative to the ring-shaped body;
wherein the ring-shaped body has an interior diameter sized to closely encircle a penis, and the head element is removably attached to the ring-shaped body; and
wherein the head element is disposed so that the head element can contact a clitoris during sexual intercourse when the ring-shaped body is positioned on the penis;
wherein the ring-shaped body has an outer peripheral portion at which the head element is provided;
wherein the head element extends in an essentially radial direction relative to the ring-shaped body;
wherein the ring-shaped body is provided with a coupling means for removably mounting the head element to the ring-shaped body; and
wherein the coupling means comprises a protruding portion extending away from the ring-shaped body and wherein the head element includes an opening adapted to accommodate the protruding portion.

US Pat. No. 10,335,305

SELF-ACTIVATED LIFTING VEST WITH SENSORY-FEEDBACK AND METHODS OF USE THEREOF

Strong Arm Technologies, ...

1. A support device comprising:a garment configured to be worn by a user, the garment including a back plate having an upper portion and a lower portion, the back plate configured and positioned to extend vertically along a central portion of a back of the user such that the upper portion of the back plate is proximate to an upper central portion of the back and the lower central portion of the back plate is proximate to a lower portion of the back when the garment is worn by the user;
a pivot point located at the upper portion of the back plate; and
at least one sensory feedback element coupled to the lower portion of the back plate, the at least one sensory feedback element configured to press into the back of the user in response to a non-ergonomic lifting posture by the user during a lifting operation, wherein the non-ergonomic lifting posture includes bending at the waist with a hunched back.

US Pat. No. 10,335,291

HYDRAULIC SYSTEM FOR A KNEE-ANKLE ASSEMBLY CONTROLLED BY A MICROPROCESSOR

PROTEOR, Saint-Apollinai...

1. A femoral knee-ankle prosthesis comprising:a femoral segment suitable for a femoral connection to a user and a tibial segment connected to the femoral segment based on an articulation which reproduces the movements of the knee, the tibial segment being articulated on one foot based on an articulation reproducing the movements of the ankle, a first hydraulic cylinder of which the ends are joined respectively with the femoral and tibial segments, and a second hydraulic cylinder of which the ends are joined respectively with the tibial segment and the foot, an upper chamber of the first hydraulic cylinder is connected to a lower chamber of the second hydraulic cylinder through a conduit connected laterally to the upper chamber of the first hydraulic cylinder, and an electronic control unit that controls both of the first hydraulic cylinder and the second hydraulic cylinder depending on the phase of the walking cycle and a situation faced by the user including a stance phase and a swing phase in such a manner that a first flexion of the knee allows a first dorsiflexion of the ankle in proportion to the movement of the knee during the stance phase and such that a second flexion of the knee results in a second dorsiflexion of the ankle in proportion to the movement of the knee during the swing phase.

US Pat. No. 10,335,288

SURGICAL IMPLANT SECURED BY PEGS AND ASSOCIATED METHODS

SpineSmith Partners, L.P....

1. An artificial disc comprising:an implantable device configured to be secured to two adjacent vertebrae, wherein the implantable device comprises:
an artificial disc that is insertable between a first vertebrae and a second vertebrae, and wherein said artificial disc comprises:
a first end plate comprising a concave inner surface;
a second end plate comprising a concave inner surface, the concave inner surface comprising a concave middle portion and a pair of concave outer portions disposed on opposite sides of the concave middle portion, wherein the pair of concave outer portions have a first curve that is different than a second curve of the concave middle portion; and
a bearing having an upper cylindrically-shaped convex surface and a lower convex surface, wherein the lower convex surface comprises a middle portion; and
wherein a first outer portion of the pair of concave outer portions is configured to be in contact with the bearing when the bearing translates within the concave inner surface of the second end plate in a first direction and a second outer portion of the pair of concave outer portions is configured to be in contact with the bearing when the bearing translates within the concave inner surface of the second end plate in a second direction that is opposite the first direction;
wherein the bearing is adapted to move relative to the first end plate and the second end plate and movement of the bearing relative to first end plate is independent of movement of the bearing relative to the second end plate; and
wherein an axis of the upper cylindrically-shaped convex surface and an axis of the lower convex surface are orthogonal to one another.

US Pat. No. 10,335,282

MAGNETIC JOINT REPLACEMENT

Richard A. Rogachefsky, ...

1. A hip joint prosthesis, comprising:a femoral head comprising a plurality of magnets positioned on an anterior surface of the femoral head, the plurality of magnets comprising a first femoral magnet and a second femoral magnet, the first femoral magnet configured to provide a stronger magnetic field than the second femoral magnet;
an acetabular cup corresponding to the femoral head, the acetabular cup comprising a second plurality of magnets positioned on a posterior surface of the acetabular cup, the second plurality of magnets comprising a first acetabular cup magnet and a second acetabular cup magnet, the first acetabular cup magnet configured to provide a stronger magnetic field than the second acetabular cup magnet;
wherein the femoral head is configured to rotate within the acetabular cup through a range of motion corresponding to about 0-120 degrees of hip flexion, the first femoral magnet positioned on a medial side of the anterior surface of the femoral head and the first acetabular cup magnet positioned on a lateral side of the posterior surface of the acetabular cup such that the first femoral magnet and the first acetabular cup magnet align to form the strongest magnetic force between the first femoral magnet and the first acetabular cup magnet when the femoral head is in a position corresponding to about 90-120 degrees of hip flexion.

US Pat. No. 10,335,264

VASCULAR GRAFT

Byung Choo Moon, Toronto...

1. An artificial blood vessel, comprising:a cylindrical inner tube having a hollow part formed therein;
an outer tube provided at an outer circumferential surface of the inner tube and surrounding the inner tube so as to form a double tube structure with the inner tube; and
a connecting line formed in circumferential directions of the inner tube and the outer tube to connect the inner tube and the outer tube, wherein the inner tube includes at least a first guide line in an axial direction, and the outer tube includes at least a second guide line in an axial direction and is positioned at a position corresponding to a position of the first guide line.

US Pat. No. 10,335,263

ORGAN FOR TRANSPLANTATION AND ORGAN STRUCTURE

BIOS CO., LTD., Tokyo (J...

1. An organ structure wherein a kidney, a first ureter, a first urinary bladder, a second ureter, and a second urinary bladder are sequentially connected in this order, wherein the first ureter, the first urinary bladder, the second ureter, and the second urinary bladder are derived from an animal.

US Pat. No. 10,335,259

3D FILTER FOR PREVENTION OF STROKE

FRID MIND TECHNOLOGIES, ...

1. An implantable endoluminal prosthesis comprising: a braided framework defining a cylindrical lumen devoid of impermeable membrane, said braided framework being self-expandable, comprising a plurality of layers of wires made of biocompatible material, each layer forming a mesh, the meshes forming a lattice with a plurality of wires of given layers, the lattice defining polygonal opening units when observed normal to a wall of the implantable endoluminal prosthesis, a diameter (?25) of the wires being at least 30 ?m and at most 150 ?m, a mean diameter (?27) of an inscribed circle of the polygonal opening units being at least 75 ?m and at most 200 ?m in a fully expanded state, characterized in that:the braided framework consists of at least 128 and at most 512 wires;
a ratio (T1?25) of a thickness (T1) of a wall of said implantable endoluminal prosthesis to the diameter (?25) of wire is at least 3.0;
in the fully expanded state, a surface coverage ratio (SCR) of said braided framework is more than 50% and less than 90%;
when the implantable endoluminal prosthesis is deployed in a curved lumen having a H/W ratio between 0.5 and 0.9, the mean diameter (?27) of the inscribed circle of opening units is at least 75 ?m and at most 200 ?m, a length-related compression ratio (LCR) being between 15% and 40%, and the surface coverage ratio (SCR) of the braided framework being more than 50% at a side of outer curve.

US Pat. No. 10,335,254

METHOD AND APPARATUS FOR RECORDING SPATIAL GINGIVAL SOFT TISSUE RELATIONSHIP TO IMPLANT PLACEMENT WITHIN ALVEOLAR BONE FOR IMMEDIATE-IMPLANT PLACEMENT

EVOLLUTION IP HOLDINGS IN...

1. A soft tissue preservation arrangement, comprising:a hollow shell with an interior volume and a shell axis, the hollow shell having an outer surface configured to engage a soft tissue socket after a tooth has been extracted from a bone socket, the shell having a first perimeter configured for placement toward the bone socket and a second perimeter configured for placement adjacent an outer surface of the soft tissue socket, the first perimeter being smaller than the second perimeter so that the shell tapers outwardly from the first perimeter to the second perimeter, the second perimeter having an asymmetrically scalloped shape; and
a temporary post having a maximum dimension that is less than a minimum dimension of the hollow shell such that when the temporary post extends in the interior volume of the hollow shell such that an interior space is formed between an outer surface of the temporary post an inner surface of the hollow shell,
wherein the minimum inside diameter of the first perimeter of the hollow shell is greater than the maximum outside diameter of the temporary post, whereby the hollow shell and the temporary post do not make physical contact during axial relative movement of the hollow shell and temporary post, wherein the temporary post has an upper end portion and a lower end portion, wherein the lower end portion is configured to engage with a dental implant such that the first outer perimeter is situated above the lower end portion.

US Pat. No. 10,335,253

TOOTH-POSITIONING APPLIANCE FOR CLOSING SPACES

Martz Inc., Bakersfield,...

1. A tooth-positioning appliance comprising:a first appliance segment having:
a shell with at least one recess for removably engaging a first tooth; and
a receptacle on the shell of the first appliance segment;
a second appliance segment having:
a shell with at least one recess for removably engaging a second tooth, wherein the first tooth and the second tooth are separated by a space; and
a tab extending laterally from the second appliance segment spanning the space and in sliding engagement with the receptacle of the first appliance segment, the shell of the second appliance segment and the tab of the second appliance segment being a single piece of material; and
an activating element connected between the first appliance segment and the second appliance segment exerting a force to change the space as the tab slides with respect to the receptacle.

US Pat. No. 10,335,250

THREE-DIMENSIONAL PRINTED DENTAL APPLIANCES USING LATTICES

uLab Systems, Inc., Redw...

1. A method for fabricating an oral appliance, comprising:capturing a three-dimensional representation of a dentition of a subject;
generating a free-form structure having a polymeric lattice structure via three-dimensional printing, wherein the lattice structure is based on the three-dimensional representation and is complementary to at least part of a surface of the dentition, wherein the lattice structure defines a plurality of open spaces such that the free-form structure is at least partially transparent; and
manufacturing the lattice structure by impregnating or covering a coating into or upon the lattice structure such that the oral appliance is formed.

US Pat. No. 10,335,244

MOBILE MEDICAL CART

NEONATAL PRODUCT GROUP, I...

1. A medical cart for transporting medical supplies, the cart comprising:a chassis having a plurality of wheels attached thereto;
a plurality of drawers supported on the chassis, wherein at least one of the drawers is slidable along a first axis toward the chassis to a closed orientation and slidable away from the chassis along the first axis to an open configuration, and wherein at least one of the drawers has a drawer lock shiftable between a locked position in which it secures the drawer in the closed orientation and an unlocked position in which it allows the drawer to be in the open configuration;
a plurality of drawer mounts disposed on interior surfaces of the chassis;
a plurality of interchangeable drawer slides attached to the plurality of drawers and removably attachable to the plurality of drawer mounts so that the drawer slides may be placed on different mounts thereby allowing different-sized drawers to be mounted to the chassis; and
a temperature-regulated compartment mounted within the chassis, the temperature-regulated compartment having a storage space with a door, a lock shiftable between a locked position in which it prevents the door from opening and an unlocked position in which it allows the door to open, and a temperature-regulating unit that regulates a temperature of the storage space at a predetermined temperature.

US Pat. No. 10,335,234

ABLATION CANNULA AND KIT WITH INSERT

ORTHOPAEDIC DEVELOPMENT, ...

1. An ablation tool comprising:a trocar;
a cannula comprising a hollow shaft, the hollow shaft of the cannula having a proximal segment and a distal segment, wherein the distal segment comprises a distal tip aligned with the hollow shaft of the cannula to permit passage of the trocar within the hollow shaft of the cannula, and having tissue-adhering irregular surfaces protruding therefrom;
an auxiliary port extending from an exterior surface of the cannula and defining a hollow passageway into the hollow shaft of the cannula; and,
an insert comprising an additional hollow shaft and adapted to be inserted into the hollow shaft of the cannula, the insert further comprising an auxiliary port extending from an exterior surface of the insert and defining a hollow passageway into the additional hollow shaft of the insert, the additional hollow shaft comprising an outside diameter of less than an interior diameter of the hollow shaft of the cannula so as to permit passage of a laser fiber through the additional hollow shaft of the insert.

US Pat. No. 10,335,233

MYOMA/POLYP IN-OFFICE TREATMENT WITH LASERS

Biolitec Unternehmensbete...

1. A method for the laser treatment of uterine growths without the use of general or regional anesthetic consisting of the steps of:a. providing a paracervical anesthetic to a cervix;
b. inserting a hysteroscope into a uterus;
c. assessing size, location and type of unwanted uterine growth;
d. placing a distal end of said hysteroscope to a position proximate to said uterine growth;
e. inserting an optical waveguide, whose proximal end is connected to a radiation source and whose distal end comprises a radiation distribution device, into said hysteroscope, wherein said radiation distribution device comprises a needle-like fiber;
f. advancing said distal end of said waveguide through said distal end of said hysteroscope to a predetermined point inside said uterine growth;
g. irradiating said uterine growth with radiation from said radiation source so as to cut/vaporize said growth to cause reduction to a size/shape for easy mechanical removal or elimination by vaporization of said uterine growth, while not impairing a patient's fertility;
h. assessing results by ultrasound imaging; and,
i. repeating steps g. and h. until unwanted growth is removed.

US Pat. No. 10,335,199

SPINAL CORRECTION CONSTRUCT AND METHOD

Warsaw Orthopedic. Inc., ...

1. A method for treating a spinal disorder, the method comprising the steps of:disposing an expandable spinal construct in a selected configuration;
fixing the spinal construct in the selected configuration with a member;
attaching a first end of the spinal construct with a bone screw that is threaded with tissue;
attaching a second end of the spinal construct with a bone screw that is threaded with tissue; and
disengaging the member from the spinal construct to release the spinal construct from the selected configuration,
wherein the member comprises a plurality of openings and a bearing positioned in each of the openings, the bearings being configured to engage a tapered portion of a sleeve of the spinal construct to prevent movement of a rod of the spinal construct relative to the sleeve in one direction.

US Pat. No. 10,335,195

PERCUTANEOUS ACCESS SYSTEMS AND METHODS

Summit Access, LLC, Engl...

1. A percutaneous access system, comprising:a cannula with an internal passageway extending through a length thereof, the internal passageway including a tapered section within an expandable section at a distal portion of the cannula, the expandable section including a plurality of leaves that are circumferentially adjacent to one another and that are capable of being forced radially outward from one another;
an obturator capable of coaxial movement through the internal passageway through the cannula; and
a handle secured to a proximal end of the cannula, the handle including a channel capable of receiving the obturator, the handle further including:
a distal hub at a fixed location relative to the proximal end of the cannula;
a main body proximal to the distal hub, the distal hub secured to a distal end of the main body; and
a proximal hub coupled to the main body in a manner that enables selective rotation of the proximal hub relative to the main body and the distal hub, selective longitudinal movement of the proximal hub toward and/or away from the main body and the distal hub, and fixed coupling of the proximal hub to a coupling element at a proximal end of the obturator such that rotational movement and/or longitudinal movement of the proximal hub relative to the distal hub causes the obturator to be driven rotationally and/or longitudinally within the internal passageway through the cannula.

US Pat. No. 10,335,193

RETROGRADE ENTRY ANTEGRADE PLACEMENT FOR FEMORAL ARTERY ACCESS

POLR ANGIOSCIENCE, LLC, ...

1. An apparatus for aiding vascular access comprising:an access director having a first lumen and a second lumen;
the first lumen extending from a head of the access director to a tip of the access director, the first lumen sized to receive an air-to-air wire to diminish bleed-back, wherein the air-to-air wire extends from outside a skin of a subject and into and out of a vascular channel of the subject and out of the skin of the subject, and wherein the first lumen does not communicate with the vascular channel; and
the second lumen extending from the head of the access director to a point proximal to the tip that ends in an oval orifice, the oval orifice having a bump located at a leading edge of the oval orifice, wherein the second lumen communicates with the vascular channel and allows bleed-back when the oval orifice is within the vascular channel, the second lumen sized to receive a wire to diminish bleed-back when the wire is received in the second lumen, wherein when the oval orifice is within the vascular channel the wire is deflected by the bump and extended out of the oval orifice and into the vascular channel.

US Pat. No. 10,335,189

SYSTEMS AND METHODS FOR PERCUTANEOUS DIVISION OF FIBROUS STRUCTURES

PAVmed Inc., New York, N...

1. A device for dividing a fibrous structure, the device comprising:a catheter having a proximal end, a distal end, and lumen extending therebetween;
an expandable member positioned near the distal end of the catheter and in fluid communication with the lumen of the catheter so that the expandable member can be biased between an inflated state and a deflated state, the expandable member having a cross-sectional shape that expands radially in a first direction more than it expands in a second direction to provide the expandable member with an elongated cross-sectional shape when inflated; and
a cutting element situated on an outer surface of the expandable member at a location that expands in the second direction, such that, as the expandable member expands in the first direction and pushes the fibrous structure in opposing lateral directions, the fibrous structure is pulled taut against the cutting element to allow tensioning of the fibrous structure against a discrete portion of the cutting element, wherein the cutting element is a blade configured to apply a mechanical force to weaken or cut the fibrous structure.

US Pat. No. 10,335,175

APPARATUS FOR REMOVING CALCULUS IN VITRO

Zhengzhou Fujianda Medica...

1. A lithagogue equipment in vitro, characteristics in that, said lithagogue equipment comprises a vibrating bed and a control device provided outside the vibrating bed; said vibrating bed includes a primary oscillator located above a bed body and connected with said bed body via an adjustable mechanical arm, and a sub oscillator protruding from an upper surface of said bed body, said control device is used to control the vibration of the primary oscillator and the sub oscillator and the movement of the bed body,wherein a length of the sub oscillator is in a range of 200-300 mm, and a height of the sub oscillator from an upper surface of the bed body is adjustable in a range of 20-50 mm such that the sub oscillator is configured to be attached to a treatment area in a waist region of a patient,
wherein the primary oscillator and the sub oscillator are configured to remove a renal calculus with a vibrating frequency of 50 Hz or less,
wherein said lithagogue equipment further comprises a scanning imaging device which is provided above said bed body and adjustably combined with the bed body, said control device includes a displaying device and a work station, the work station transfers images scanned by the scanning imaging device to the displaying device, and
wherein a pressure sensor is provided inside of the primary oscillator, the pressure value applied by the primary oscillator is displayed by the displaying device of the control device.

US Pat. No. 10,335,167

DRILL BIT AND METHOD FOR PRODUCING A DRILL BIT

SURGIBIT IP HOLDINGS PTY ...

1. A medical device for use during surgery, said device comprising a shaft and a tapered tip for drilling into a surface of body material; the tip including a plurality of faces, each face having at least two sub-faces formed and arranged to define a generally pyramidal shaped remote end terminating in an extreme drill point whereby the remote end is adapted to pierce the surface and thereby locate the tip prior to drilling; and whereinthe shaft and tip includes at least one flute having a first portion and a second portion;
wherein the first portion is generally helical and extends at least partially along the shaft;
wherein the second portion is formed in the tip and associated with a respective sub-face and extends partway along the tip behind the drill point;
wherein the second portion includes a groove formed in the tip and adjacent at least one edge of the respective sub-face, thereby to enhance the cutting ability of the tip;
wherein the first portion intersects with the second portion to direct debris away from the tip during drilling; and
wherein the sub-faces are asymmetrically offset about a center line of the respective face.

US Pat. No. 10,335,166

SURGICAL BURS WITH DECOUPLED RAKE SURFACES AND CORRESPONDING AXIAL AND RADIAL RAKE ANGLES

MEDTRONICS PS MEDICAL, IN...

1. A surgical bur comprising:a plurality of flutes, wherein each of the plurality of flutes comprises a cutting edge;
a plurality of rake surfaces;
a planar clearance surface,
wherein the plurality of rake surfaces of one of the flutes comprises
a first rake surface having a first rake angle and a first distinct planar surface, and
a second rake surface having a second rake angle and a second distinct planar surface, wherein the second rake angle is decoupled from the first rake angle, and wherein the first rake surface and the second rake surface are distinct from the planar clearance surface; and
a plurality of lands, wherein each of the plurality of lands is disposed between a pair of the plurality of flutes;
wherein:
the first rake surface of the one of the flutes has a negative axial rake angle; and
the second rake surface of the one of the flutes has a positive radial rake angle.

US Pat. No. 10,335,160

TOURNIQUET BELT

Ballistipax, LLC, Melbou...

1. A tourniquet belt comprising:a first elongate fabric member having a first stiffness, a length, a first side, an opposing second side, a first end, and an opposing second end;
a second elongate fabric member having a first side, an opposing second side, a second stiffness greater than the first stiffness, and affixed to the first elongated fabric member with the second side of the second elongate fabric member proximate the first side of the first elongate fabric member, wherein an area of the second elongate fabric member, which overlays the first elongate fabric member, defines a tourniquet portion of the first elongate fabric member;
a third elongate fabric member having a length, a first side, an opposing second side, a first end, and an opposing second end, wherein the third elongate fabric member is secured to the first elongate fabric member with the second side of the third elongate fabric member proximate the first side of the first elongate fabric member and a second end of the third elongate fabric member proximate the tourniquet portion, wherein the first end of the third elongate fabric member extends distal the tourniquet portion and secures to the first elongate fabric member along the lengths of the third elongate fabric member and the first elongate fabric member to form a first pocket having a first pocket opening proximate the tourniquet portion of the first elongate fabric member;
a fourth elongate fabric member having a length, a first side, an opposing second side, a first end, and an opposing second end, wherein the fourth elongate fabric member is secured to the first elongate fabric member with the second side of the fourth elongate fabric member proximate the first side of the first elongate fabric member and a second end of the fourth elongate fabric member proximate the tourniquet portion, wherein the first end of the fourth elongate fabric member extends distal the tourniquet portion and secures to the first elongate fabric member along the lengths of the fourth elongate fabric member and the first elongate fabric member and the first end of the fourth elongate fabric member to form a second pocket having a second pocket opening proximate the tourniquet portion of the first elongate fabric member;
a fifth elongate fabric member carried within the first pocket, extending through the first pocket opening, across the tourniquet portion, through the second pocket opening, and carried within the second pocket;
a belt fastener secured to the first end of the first elongate fabric member, and
a windlass carried by the fifth elongate fabric member along the tourniquet portion.

US Pat. No. 10,335,156

SELF-ADAPTING FLOATING DIAMETER EMBOLIC COIL

NDI TIP TEKNOLOJILERI ANO...

1. A vaso-occlusive device, consisting of:a self-adaptive floating diameter member, consisting of:
a distal end with an anchoring loop for anchoring said self-adaptive floating diameter member to an inner surface of a vessel at a site of an embolization procedure;
a proximal end with a proximal loop for detaching from a gripper assembly adapted to deliver to said site of said embolization procedure;
a primary coil arrangement configured with a plurality of primary omega curves extending along a length of said self-adaptive floating diameter member between said proximal end and said distal end;
a secondary coil arrangement configured with a plurality of secondary omega curves extending along a trajectory along said length of said self-adaptive floating diameter member-between said proximal end and said distal end, said plurality of secondary omega curves configured in an arcuate curvature comprising an upper crest portion and a lower trough portion following said trajectory of said plurality of primary omega curves about a longitudinal axis of said self-adaptive floating diameter member between said proximal end and said distal end; and
whereby said primary coil arrangement and said secondary coil arrangement in a relaxed, state in the patient's body substantially assume a shape of said inner surface of said vessel at said site of said embolization procedure.

US Pat. No. 10,335,154

POLYMERIC ELECTROSPUN EMBOLIZATION DEVICE AND METHODS OF USE

IkoNano Venture Partners,...

1. A method of deploying an embolization device, the method comprising:inserting into a vessel the embolization device, the embolization device comprising a fiber section comprising a plurality of polymeric electrospun fibers, wherein the embolization device further comprises a plurality of fiber sections, wherein each fiber section is separated by a linker; and
applying an electrical current to one or more of the linkers, wherein the electrical current is from about 0.1 mA to about 100 mA.

US Pat. No. 10,335,149

ARTICULATABLE SURGICAL INSTRUMENTS WITH COMPOSITE FIRING BEAM STRUCTURES WITH CENTER FIRING SUPPORT MEMBER FOR ARTICULATION SUPPORT

Ethicon LLC, Guaynabo, P...

20. A surgical instrument, comprising:an elongate shaft assembly defining a shaft axis;
a surgical end effector operably coupled to said elongate shaft assembly by an articulation joint such that said surgical end effector is selectively articulatable relative to said elongate shaft assembly about an articulation axis that is transverse to said shaft axis;
a firing member movably supported for axial travel between a proximal end portion of said surgical end effector and a distal end portion of said surgical end effector;
a central firing beam support member axially aligned along said shaft axis and extending across said articulation joint and comprising a distal end coupled to said surgical end effector and a proximal end attached to said elongate shaft assembly; and
a longitudinally movable flexible firing beam assembly comprising a plurality of beam layers such that as said longitudinally movable flexible firing beam assembly is distally advanced, said longitudinally movable flexible firing beam assembly is bifurcated by said central firing beam support member so that portions of said longitudinally movable flexible firing beam assembly pass adjacent to each lateral side of said central firing beam support member, said longitudinally movable flexible firing beam assembly configured to drive said firing member between said proximal and distal end portions of said surgical end effector.

US Pat. No. 10,335,146

SURGICAL FASTENER APPLYING APPARATUS, KITS AND METHODS FOR ENDOSCOPIC PROCEDURES

Coviden LP, Mansfield, M...

1. An endoscopic surgical device, comprising;a handle assembly including a handle housing and a trigger operatively connected to the handle housing, and a drive mechanism actuatable by the trigger, wherein the handle housing includes a tooth projecting from a surface thereof, wherein the handle assembly includes a ferrule removably and rotatably connected to the handle housing, the ferrule defining an aperture therein that is in operative alignment with the drive mechanism of the handle assembly, the ferrule including a tooth projecting radially into the aperture of the ferrule, the ferrule having:
a first position wherein the tooth of the ferrule is radially aligned with the tooth of the handle housing; and
a second position wherein the tooth of the ferrule is radially out of alignment with the tooth of the handle housing; and
an endoscopic assembly selectively connectable to the handle assembly, the endoscopic assembly including:
an outer tube defining a lumen therethrough and having an outer helical thread disposed within the lumen thereof, the outer tube defining a proximal end and a distal end;
an inner tube rotatably supported in the outer tube, the inner tube defining a lumen therethrough and having a proximal end and a splined distal end, wherein the splined distal end of the inner tube is defined by a pair of opposed longitudinally extending tines and a pair of opposed longitudinally extending channels;
a plurality of surgical anchors loaded in the lumen of the inner tube of the endoscopic assembly, wherein each anchor of the plurality of surgical anchors includes a threaded body portion, and a head portion defining a pair of opposed radially outer threads and a pair of opposed radial recesses, wherein the pair of radial recesses of each head portion receives a respective tine of the pair of opposed longitudinally extending channel of the inner tube and wherein the pair of opposed radially outer threads of each head portion projects from the pair of opposed longitudinally extending channels of the inner tube and engage the inner helical thread of the outer tube; and
a connector having:
an outer connector member non-rotatably connected to the proximal end of the outer tube and being non-rotatably connectable to the handle assembly, the outer connector member including a channel formed therein, wherein:
the channel of the outer connector member receives the tooth of the handle housing when the endoscopic assembly is connected to the handle assembly; and
the tooth inhibits rotation of the outer connector member when the trigger is actuated to rotate the inner connector member of the endoscopic assembly; and
an inner connector member non-rotatably connected to the proximal end of the inner tube and being non-rotatably connectable to the drive mechanism, wherein the outer connector member and the inner connector member are rotatable with respect to one another.

US Pat. No. 10,335,135

FIXING DEVICE FOR SUTURE THREADS TO BE INSERTED INTO A BONE TISSUE

NCS LAB S.R.L., Carpi (I...

1. A fixing device for suture threads to be inserted into a bone structure, comprising a first portion (11, 21) and a second portion (12, 22), the device having an undeployed state, a deployed state, and a longitudinal dimension, the deployed state being a state when the device is deployed in a bone structure, the first portion (11, 21) being provided with a first eyelet (10, 20) or eye effectively sized to receive a first suture thread (4) therethrough, the first eyelet or eye defining an opening which extends through the device in a direction substantially perpendicular to the longitudinal dimension in the undeployed state, the second portion (12, 22) exhibiting a second eyelet or eye effectively sized to receive a second suture thread (4) therethrough, the second portion (12, 22) comprising an engagement portion which is effectively sized and shaped such that it can effectively contact and engage an interior surface of a transosseus seating or hole (5) afforded in the bone structure to thereby stably couple the device with the bone structure, the second portion (12, 22) having a neck portion located between the engagement portion and the first portion, the engagement portion being spaced apart from the first portion, the engagement portion having a medial portion and a distal portion, the medial portion being located between the neck portion and the distal portion, the device being configured so that, in use, the engagement portion is inserted, distal portion first, into the transosseus seating or hole (5), the neck portion having a first width transverse to the longitudinal dimension, the first portion comprising a mushroom-shaped portion having a second width transverse to the longitudinal dimension, the second width being larger than the first width in both the undeployed state and the deployed state, the second width being larger than the first width when the first eyelet or eye defines the opening in the undeployed state, the mushroom-shaped portion being integral with the neck portion, the neck portion being integral with the engagement portion, the mushroom-shaped portion extending beyond the neck portion in a first direction transverse to the longitudinal dimension in both the undeployed state and the deployed state, the mushroom-shaped portion extending beyond the neck portion in a second direction transverse to the longitudinal dimension in both the undeployed state and the deployed state, the second direction being opposite to the first direction, and wherein at least the second portion (12, 22) is elastically deformable in order to enable effective coupling to the transosseus seating or hole (5).

US Pat. No. 10,335,134

MAGNARETRACTOR SYSTEM AND METHOD

Attractive Surgical, LLC,...

1. A system for manipulating tissue inside a body of a patient, comprising:an intracorporeal apparatus comprising a body comprising
a first end comprising a clip, and
a second end comprising a magnet or magnetically responsive material, wherein the second end is adapted to engage with a placement apparatus; and
a placement apparatus comprising:
an elongated body comprising a proximal end and a distal end;
a shaft disposed within the elongated body and comprising
a shaft proximal end, and
a shaft distal end adapted to selectively engage and disengage the intracorporeal apparatus; and
a handle located at the proximal end of the elongated body and operably connected to the proximal end of the shaft.

US Pat. No. 10,335,127

BIOPSY DEVICE WITH SELECTABLE TISSUE RECEIVING APERATURE ORIENTATION AND SITE ILLUMINATION

SenoRx, Inc., Franklin L...

1. A method for collecting one or more tissue specimens from a target site within a patient, comprising:a. providing a biopsy device having:
i. a disposable elongated probe component comprising:
an elongated tubular section which has a longitudinal axis, which has an inner lumen extending therein, which has a penetrating distal tip and which has a tissue receiving aperture proximal to the penetrating distal tip configured to receive tissue from the target site,
a first driven gear coupled to the elongated tubular section and configured to rotate, to in turn rotate the elongated tubular section around the longitudinal axis,
an elongated tissue cutting member which is disposed within the elongated tubular section, which has a distal end having at least one tissue cutting edge and which has an inner lumen extending therein, the elongated tissue cutting member having a proximal end opposite the distal end, and
a second driven gear coupled to the elongated tissue cutting member and configured to rotate to longitudinally move the elongated tissue cutting member relative to the elongated tubular section along the longitudinal axis,
the first driven gear and the second driven gear being arranged coaxially and adjacent each other on the longitudinal axis;
ii. a driver component configured to receive a proximal portion of the disposable elongated probe component in an operational relationship, the driver component having:
a first driver unit configured to rotate the elongated tubular section of the disposable elongated probe component to orient the tissue receiving aperture of the elongated tubular section, the first driver unit having a first drive gear, and
a second driver unit configured to drive the elongated tissue cutting member longitudinally within the elongated tubular section to cut a tissue specimen from the tissue received in the tissue receiving aperture of the elongated tubular section, the second driver unit having a second drive gear positioned adjacent the first drive gear,
the first drive gear and the second drive gear of the driver component configured to respectively drivably engage the first driven gear and the second driven gear that are arranged coaxially and adjacent to each other on the longitudinal axis; and
iii. a tissue collection device located at the proximal end of the elongated tissue cutting member, a portion of the elongated tissue cutting member being positioned inside the tissue collection device;
b. advancing the disposable elongated probe component at least partially into or adjacent to tissue at the target site;
c. rotating the elongated tubular section about the longitudinal axis by the first driver unit to a predetermined aperture orientation of the tissue receiving aperture;
d. applying a vacuum within the elongated tubular section to draw the tissue at the tissue site through the tissue receiving aperture of the elongated tubular section into an interior thereof;
e. advancing the elongated tissue cutting member longitudinally within the elongated tubular section by the second driver unit to cut the tissue specimen from the tissue extending into the elongated tubular section; and
f. applying a vacuum to the proximal end of the elongated tissue cutting member for transporting the cut tissue specimen through the inner lumen of the elongated tissue cutting member to discharge the cut tissue specimen directly from the proximal end of the elongated tissue cutting member into the tissue collection device.

US Pat. No. 10,335,113

APPARATUS FOR ULTRASOUND FLOW VECTOR IMAGING AND METHODS THEREOF

VERSITECH LIMITED, Hong ...

1. An ultrasound imaging system comprising:a data acquisition unit, which transmits, via an ultrasonic array transducer, a series of plane waves into a tissue and receives waves reflected from the tissue to obtain beam-formed data frames;
a flow vector estimation unit which estimates flow vectors at pixels of the data frames using data of the data frames; and
a display rendering circuit which displays, on a display, the flow vectors estimated as color coded moving projectiles having varying lengths and colors themselves across the moving projectiles based on velocity magnitudes of one or more flow vectors of the flow vectors corresponding to the moving projectiles, wherein positions of the projectiles are dynamically updated between data frames based on axial lateral velocities of the projectiles representing the corresponding flow vectors across the data frames and one or more inter-frame periods between the data frames to depict movement of the projectiles corresponding to one or more flow patterns in the tissue.

US Pat. No. 10,335,098

PANORAMIC IMAGING APPARATUS AND DIAGNOSTIC IMAGING METHOD IN SAME APPARATUS

AXION JAPAN CO., LTD., S...

1. A dental panoramic imaging apparatus, comprising:an X-ray source irradiating X-rays;
a detector receiving the X-rays, converting the X-rays to digital electric signals pixel by pixel, and outputting, as frame data, the electric signal at a constant rate;
a moving member moving the X-ray source and the detector around a jaw portion of a subject being examined, the X-ray source and the detector being located opposite to each other with the subject therebetween;
a data storage unit storing therein the frame data outputted from the detector while the moving member moves the X-ray source and the detector around the jaw portion of the subject;
a display unit;
a processor; and
an operating unit operated by a user;
wherein the processor is configured to, responsively to user's instructions issued via the operating unit,
generate data of an optimally focused panoramic image of a section along curved dentitions in the jaw portion, based on the frame data stored in the data storage unit;
display the generated optically focused panoramic image on the display unit;
superimposedly display both information and a measurement line on the panoramic image displayed on the display unit, the information indicating a restricted range in a vertical direction on the panoramic image, the vertical direction being approximately vertical to a lateral direction which is along the dentitions, the measurement line positioned within the restricted range on the panoramic image in the vertical direction, wherein said measurement line is provided for analyzing a degree of loss of alveolar bone supporting teeth at a tooth row of the jaw portion of the subject;
designate; on the panoramic image, via interactive operator input on the input unit, a position of the measurement line by changing a position of the measurement line superimposed on the panoramic image within the restricted range in the vertical direction, such that the position of the measurement line is decided based on a feature point or a reference point associated with the feature point, the feature point indicating features of both one or more teeth being targeted among the whole teeth and a support portion which supports the one or more of the whole teeth at the alveolar bone;
measure a length on the panoramic image displayed on the display unit, wherein the length is decided based on the feature point or the reference point designated; and
analyze the degree of loss of the support portion of the alveolar bone, based on the measured length.

US Pat. No. 10,335,079

ASSESSING COGNITION USING ITEM-RECALL TRIALS WITH ACCOUNTING FOR ITEM POSITION

Medical Care Corporation,...

1. A computer-implemented method comprising:receiving data comprising responses, and lack thereof, for items of a cognitive test, wherein the cognitive test comprises multiple item-recall trials used to assess cognition;
processing the data using a stochastic model of a cognitive process, in which a conditional probability distribution of future states of the cognitive process depend only upon a present state; and
encoding a result of the processing on a non-transitory computer-readable medium to supply the result to a computer device for use in an assessment related to cognition;
wherein the processing using the stochastic model comprises representing recall of an item in the multiple item-recall trials using distinct cognitive states; and
wherein the processing using the stochastic model comprises adjusting separate memory storage and retrieval parameters for each of the distinct cognitive states in the modeled cognitive process to account for position of the items in each respective trial of the multiple item-recall trials.

US Pat. No. 10,335,064

SYSTEMS AND METHODS FOR APPLYING OR RECEIVING SIGNALS TO OR FROM BIOLOGICAL TISSUES

COMBOBUTRONICS LLC, Glen...

1. A method of applying and/or receiving an electrical signal via a biological tissue portion, the method comprising:positioning a first system against a first skin portion on a user's head, wherein the first system comprises:
a first body;
a first conductor configured to be electrically coupled to at least one of a power source and a detector;
a first electrode, the first electrode comprising a surface configured to contact the first skin portion and apply and/or receive an electrical signal to and/or from the first skin portion; and
a first magnetic element, the first magnetic element being selected from the group consisting of: a magnet, a toroid, a conductive coil, a magnetic powder, and a magnetic fluid;
positioning a second system against a second skin portion on the user's head, wherein the second system comprises:
a second body;
a second electrode, the second electrode comprising a surface configured to contact the second skin portion and apply and/or receive an electrical signal to and/or from the second skin portion; and
a second magnetic element, the first magnetic element being selected from the group consisting of: a magnet, a toroid, a conductive coil, a magnetic powder, and a magnetic fluid;
applying or receiving, using the first electrode, a first electrical signal via the first skin portion, wherein a first energy field applied or received by the first electrode is distributed in a different pattern than said first energy field would have been distributed if the first magnetic element were not present; and
applying or receiving, using the second electrode, a second electrical signal via the second skin portion, wherein the second energy field applied or received by the second electrode is distributed in a different pattern than said second energy field would have been distributed if the second magnetic element were not present
wherein the first signal is applied by the first electrode and the second signal is received by the second electrode, the method further comprising: generating data based on the second signal, wherein the second signal is related to the first signal such that the data generated based on the second signal is configured to be analyzed to assess whether the second signal was received after the first signal was applied.

US Pat. No. 10,335,063

SYSTEMS AND METHODS FOR APPLYING OR RECEIVING SIGNALS TO OR FROM BIOLOGICAL TISSUES

COMBOBUTRONICS LLC, Glen...

1. A system for applying and/or receiving an electrical signal, the system comprising:a first earpiece comprising:
a first conductive tip, the first tip comprising a first channel and a first outer surface having a shape that approximates a portion of a sphere or cone, the first tip being sized to fit within a user's first ear;
a first base configured to be coupled to the first tip, the first base comprising a first conductor in electrical contact with the first tip such that an electrical signal may pass between the first base and the first tip;
a second earpiece comprising:
a second conductive tip, the second tip comprising a second channel and a second outer surface, the second tip being sized to fit within a user's second ear;
a second base configured to be coupled to the second tip, the second base comprising a second conductor in electrical contact with the second tip such that an electrical signal may pass between the second base and the second tip;
a power source, the power source being connected to the first earpiece to apply a first electrical signal within the user's first ear via the first earpiece;
a detector, the detector being connected to the second earpiece to receive a second electrical signal from the user's second ear via the second earpiece;
wherein the system, using the power source and the detector, is configured to apply the first electrical signal to the first ear and receive the second signal from the user's second ear simultaneously; and
wherein the system, using a processor, is configured to generate data based on the second electrical signal, the second electrical signal being related to the first electrical signal such that the data generated based on the second electrical signal is configured to be analyzed to assess whether the second electrical signal was received after the first electrical signal was applied.

US Pat. No. 10,335,057

METHOD AND APPARATUS FOR DEPTH MEASUREMENT

Exaxion Scientific, LLC, ...

1. An apparatus for performing a measurement of the depth of a drilled hole, comprising:a controller module having a first and second input, and also having a first and second output;
a switch module having an output coupled to the first input of said controller module, and which provides a command interface to a human operator through a tactile element;
a stepper/encoder unit having an input coupled to the first output of said controller module, and also having an output;
a linear actuator driven by said stepper/encoder unit, and also having a segment which can be inserted into said drilled hole;
a position sensor mechanically coupled to said linear actuator, and also having an output; and
a display unit which is coupled to the second output of said controller module, and which provides a readout to a human operator,
wherein said controller module controls said stepper/encoder unit and, based on input from said position sensor, executes an algorithm for (i) at least one of semi-autonomous or fully autonomous alignment of said distal end of said linear actuator with a distal end of said drilled hole and (ii) calculating linear displacement of said linear actuator,
wherein said stepper/encoder unit converts commands from said controller module into discrete amounts of at least one of angular or linear mechanical movement,
wherein said linear actuator slides back and forth in response to the angular or mechanical movements of said stepper/encoder unit,
wherein said position sensor produces an electronic signal having a magnitude transition indicating when the end of said drilled hole has been reached, and
wherein the display unit provides a readout indicating a measure of the linear displacement of said linear actuator.

US Pat. No. 10,335,056

SENSOR FOR ELECTRICALLY MEASURING A FORCE HAVING A SPRING UNIT ARRANGED IN-BETWEEN SURFACES

Novel GmbH, Munich (DE) ...

1. A sensor for electrically measuring a force acting on the sensor within a specified measuring range, which force is distributed unevenly over a measurement surface of the sensor, wherein an electrical force measurement signal is generated, comprising:a spring device which is arranged between the measurement surface and a counter-surface,
a first measuring element arranged in or on the measurement surface and a second measuring element is arranged in or on the counter-surface, the first and second measuring elements comprising capacitor plates covering these surfaces,
wherein the measurement surface and the counter-surface plus the measuring elements are elastically deformable,
wherein the measuring elements generate a measuring signal from a distance between the measuring elements,
wherein the spring device has a large number of incompressible but elastically designed spring members which are arranged spaced apart from each other by gaps, wherein each spring member upon loading by the force or a fraction of this force can deform, into the gaps and hence in a space-consuming manner,
wherein the height for each spring member between the measurement surface and the counter-surface upon loading of the sensor by the force within the specified measuring range is linearly proportional to a partial force acting thereon,
wherein the measurement surface and the counter-surface further include shielding elements for electrically shielding the first and second measuring elements, the shielding elements being separated from the capacitor plates of the first and second measuring elements by a dielectric, and
further including a capacitance measuring device connected to the shielding elements and to the capacitor plates of the first and second measuring elements to measure the capacitances between the shielding elements and the capacitor plates to obtain a temperature signal to be used to correct the measuring signal.

US Pat. No. 10,335,054

METHOD FOR DETECTING FLUID IN CRANUIM VIA TIME VARYING MAGNETIC FIELD PHASE SHIFTS

CEREBROTECH MEDICAL SYSTE...

1. A method for monitoring intracranial fluid in a patient's head, the method comprising:placing a headset on the patient's head, wherein the headset includes a first transmitter positioned at a first location on the headset, a second transmitter positioned at a second location on the headset offset from the first location, a receiver positioned at a third location on the headset offset from the first and second locations, and a processor comprising a field-programmable gate array;
providing a first signal to the first transmitter from the frequency synthesis field-programmable gate array, wherein providing the first signal includes:
producing, with the frequency synthesis field-programmable gate array, a square wave clock signal for generating a first time-varying magnetic field in the first transmitter and a sampling signal at an offset in frequency from the square wave clock signal; and
amplifying the square wave signal;
transmitting from the first transmitter, in response to the first signal, the first time-varying magnetic field through the intracranial fluid and toward the receiver;
receiving the first time-varying magnetic field with the receiver based on the sampling signal;
generating, with the receiver, a second signal responsive to the received first time-varying magnetic field;
transmitting the second signal from the receiver to the processor;
determining, with the processor of the headset, a first phase shift between the transmitted first time-varying magnetic field and the received first time-varying magnetic field for a plurality of frequencies of the transmitted first time-varying magnetic field;
providing a third signal to the second transmitter from the frequency synthesis field-programmable gate array;
transmitting from the second transmitter, in response to the third signal, a second time-varying magnetic field through the intracranial fluid and toward the receiver;
receiving the second time-varying magnetic field with the receiver;
generating, with the receiver, a fourth signal responsive to the received second time-varying magnetic field;
transmitting the fourth signal from the receiver to the processor;
determining, with the processor, a second phase shift between the transmitted second time-varying magnetic field and the received second time-varying magnetic field for a plurality of frequencies of the transmitted second time-varying magnetic field; and
determining, with the processor, an analysis of the intracranial fluid based on the first phase shift and the second phase shift.

US Pat. No. 10,335,045

SELF-ADAPTIVE MATRIX COMPLETION FOR HEART RATE ESTIMATION FROM FACE VIDEOS UNDER REALISTIC CONDITIONS

Universita degli Studi Di...

1. A method of determining heart rate through observation of a human face, comprising:acquiring with at least one automated camera, a time series of images of a human face, wherein the time series of images are subject to variations between respective images of the time series in illumination and facial movements;
adaptively selecting, with the at least one automated processor, a subset of the regions of interest of respective images of the time series of images of the human face, that exhibit a more statistically reliable heart-rate-determined variation than a non-selected subset of regions of the respective images of the human face;
based at least on the adaptively selected subset of regions of interest of the respective images of the time series of the human face that exhibit the reliable heart-rate-determined variation, determining a heart rate, and updating the adaptively selected subset of the regions of interest that exhibit the reliable heart-rate-determined variation; and
outputting a signal corresponding to the determined heart rate.

US Pat. No. 10,335,038

SPECTRAL UNMIXING FOR IN-VIVO IMAGING

Xenogen Corporation, Ala...

1. A method for spectrally unmixing light data corresponding to light emitted from multiple light sources internal to an animal, the method comprising:selecting an excitation wavelength band for excitation light provided to the animal;
selecting an emission wavelength band that limits light wavelengths collected from the animal;
providing excitation light, into the animal, that is limited to the excitation wavelength band;
capturing a first image of at least a portion of the animal, where the first image includes light data that is limited in wavelength to the emission wavelength band and corresponds to light emitted by multiple fluorescent light sources internal to the animal;
changing the excitation wavelength band and/or the emission wavelength band;
capturing at least one additional image of at least the portion of the animal that uses a different combination of excitation wavelength band and emission wavelength band for each additional image, where each additional image includes light data that corresponds to light emitted by the multiple fluorescent light sources internal to the animal and is limited in wavelength to the emission wavelength band of the different combination; and
unmixing spectra for the multiple fluorescent light sources derived from the first image limited in wavelength to the emission wavelength band and the at least one additional image limited in wavelength to the emission wavelength band to determine a pure spectrum for each light source in the animal using an iterative solution process by a processor,
wherein said iterative solution process by the processor includes applying both a unimodality constraint that limits the pure spectrum for each light source in the process to having a single peak, and a bandpass constraint that limits the pure spectrum for each light source in the process to within a desired wavelength range.

US Pat. No. 10,335,036

PULSED ULTRASOUND MODULATED OPTICAL TOMOGRAPHY USING LOCK-IN CAMERA

HI LLC, Los Angeles, CA ...

1. An ultrasound modulated optical tomography (UOT) system, comprising:an acoustic assembly configured for delivering ultrasound into a target voxel within an anatomical structure;
an interferometer configured for delivering sample light into the anatomical structure, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that combines with the signal light to create a sample light pattern, the interferometer further configured for combining reference light with the sample light pattern to generate an interference light pattern;
a controller configured for operating the acoustic assembly and the interferometer to pulse the ultrasound and the sample light in synchrony, such that only the signal light is frequency shifted by the ultrasound, the controller further configured for operating the interferometer to sequentially modulate the interference light pattern to generate a plurality of different interference light patterns;
a lock-in camera having an array of detectors configured for simultaneously detecting spatial components of each different interference light pattern, wherein each detector of the lock-in camera respectively stores a plurality of values in a plurality of bins of the lock-in camera representative of the respective spatial components of the interference light patterns, wherein the controller is configured for synchronizing operation of the acoustic assembly, the interferometer, and the array of detectors of the lock-in camera, such that the different interference light patterns are detected at specific points on a cycle of the ultrasound; and
a processor configured for determining a physiologically-dependent optical parameter of the target voxel based on the plurality of values stored in the bins of each detector.

US Pat. No. 10,335,027

METHODS AND APPARATUS FOR ASSESSMENT OF REFRACTIVE CONDITION

EYENETRA, INC., Cambridg...

1. A method comprising:(a) capturing, with a light sensor, an unfocused image of a first spatial light modulator (SLM), which unfocused image is formed by light that has entered and exited an eye and then passed through a first lens-system;
(b) analyzing differences between a first visual pattern and a second visual pattern; and
(c) computing a refractive aberration of the eye, based at least in part on the differences;wherein(1) the first SLM is positioned optically between the eye and the light sensor,
(2) the first visual pattern comprises the unfocused image or comprises a transformation of the unfocused image,
(3) the second visual pattern comprises a second image of the first SLM that is not distorted by the refractive aberration of the eye,
(4) an artificial light source emits the light,
(5) a second SLM is positioned optically between the light source and the eye,
(6) the light passes through a second lens system that is optically between the light source and the eye, and
(7) the second lens system has an optical power that prevents the eye from focusing on the second SLM and from focusing on the light source.

US Pat. No. 10,335,016

REFLECTIVE OPTICAL OBJECTIVE

Ecole Polytechnique Feder...

1. A microscope comprising:an optical array of objectives, each objective comprising:
a first reflecting element having a convex or flat front surface and a back surface, wherein the front surface is reflective,
a second reflecting element having a concave reflecting surface facing the front surface of the first reflecting element, wherein the second reflecting element comprises a transmissive section permitting electromagnetic radiation to pass through the concave reflecting surface of the second reflecting element to the first reflecting element, and
a carrier material between at least the front surface of the first reflecting element and the concave reflecting surface of the second reflecting element;
a bundle of flexible waveguides, wherein each objective of the optical array is optically coupled to a single flexible waveguide of the bundle of flexible waveguides;
an inner housing that encloses the optical array and at least a portion of the bundle of flexible waveguides;
an outer housing that at least partially surrounds the inner housing; and
a micro-actuator attached to the outer housing that, upon activation, moves the inner housing relative to the outer housing such that the optical array moves with the inner housing along a scan pattern to collect light with the optical array of objectives at each of a plurality of positions in the scan pattern in order to form an image based on the light collected with all of the objectives of the optical array,
wherein a dimension of the scan pattern is no larger than a distance between adjacent objectives in the optical array of objectives.

US Pat. No. 10,335,015

MEDICAL BORESCOPES AND RELATED TIP ASSEMBLIES

Xenocor, Inc., Salt Lake...

1. A medical borescope, comprising:a handle;
a tube extending from the handle, wherein the tube comprises a non-conductive material;
a tip assembly positioned at a distal end of the tube, wherein at least a portion of the medical borescope device is disposable, and wherein the tip assembly comprises:
a housing;
a light source;
a lens assembly;
an image sensor; and
a printed circuit board; and
a dongle comprising an image processor configured to receive image data from the image sensor, wherein the dongle is removably coupleable with the handle of the medical borescope, and wherein the entire medical borescope including the handle, the tube and the tip assembly is disposable such that the dongle can be removed from the handle of the medical borescope and coupled with a handle of a new medical borescope upon disposal of the medical borescope.

US Pat. No. 10,334,997

TOILET PAPER DISPENSER

HANDY TISSUE, LLC, Liber...

1. A toilet paper dispenser which is rotatable for storage behind the toilet seat when not in use, the dispenser comprising:a) a proximal horizontal segment for mounting to a toilet bowl fixture via a mounting bolt of a toilet seat, the proximal horizontal segment including a bolt hole for receiving the mounting bolt, the bolt hole comprising:
i) an upper ledge;
ii) a lower ledge;
iii) an upper transverse wall;
iv) a lower transverse wall;
v) an upper straight wall; and
vi) a lower straight wall, wherein the upper transverse wall and the lower transverse wall form a transverse cylinder centered about an axis A of the bolt hole, wherein the upper straight wall and the lower straight wall do not engage the screw threads of the mounting bolt and form a straight cylinder centered about an axis B of the bolt hole when the mounting bolt is aligned with axis B, wherein each ledge engages the screw threads of the mounting bolt when the mounting bolt is aligned with axis B, and wherein the bolt hole allows the dispenser to be installed and secured in place on the mounting bolt without the need of a retaining nut;
b) a descending segment; and
c) a distal horizontal segment for receiving a roll of toilet paper, wherein the proximal horizontal segment, the descending segment, and the distal horizontal segment are made of a single piece construction.

US Pat. No. 10,334,994

BODY SCRUBBER HOLDING APPARATUS

Reach Your Clean, LLC, P...

1. A holder apparatus comprising:a proximal end opposite a distal end, with a handle disposed at the proximal end and a holder portion disposed at the distal end, with a body portion disposed between the proximal and distal ends, the body portion coupled to each of the handle and the holder portion;
the body portion being flexible, such that the body portion is capable of bending when experiencing a strain force, and return to its original orientation when no longer experiencing the strain force;
the holder portion including a frame having:
a top surface, a bottom surface, and a side wall connecting the top surface with the bottom surface, the top surface, bottom surface, and side wall defining a holding aperture;
a lip disposed on the bottom surface and extending radially from the side wall of the frame, such that the bottom surface includes a diameter less than a diameter of the top surface;
a plurality of retention pins disposed on the lip and extending transversely therefrom toward the holding aperture, the frame adapted to receive and retain a cleaning implement thereto, with the plurality of retention pins adapted to be at least partially secured within the cleaning implement.

US Pat. No. 10,334,988

FOOD PORTIONING SYSTEM

The Nutrition Group, Inc....

1. A food portioning system comprising:(a) a support comprising a plurality of rails defining an opening configured to receive a container; and
(b) a bracket coupled with the support, wherein the bracket comprises a pair of rods extending upwardly from the support and a scrape bar positioned above the opening, wherein the pair of rods couple the scrape bar with the support, wherein the pair of rods are coupled with the support such that the position of the plurality of rails of the support are fixed relative to each other, wherein the scrape bar is configured to portion food within a serving implement;
wherein the pair of rods comprises a first pair of openings aligned through a first lateral axis between the pair of rods and a second pair of openings aligned through a second lateral axis between the pair of rods, wherein the first lateral axis is positioned above the second lateral axis, and
wherein the scrape bar is selectively insertable within the first pair of openings and the second pair of openings such that a height of the scrape bar is adjustable relative to the support.

US Pat. No. 10,334,986

METHOD AND DEVICE FOR MAKING NUT BUTTER AND NUT MILK

ETERNAL EAST (HK) LTD., ...

1. A device for producing nut butter and/or nut milk from nuts, comprising:a base having a motor configured to drive a shaft;
an outer container positioned above the base;
a mixing container positioned within the outer container, the mixing container comprising inner sidewalls, a bottom surface, and at least one screen arranged in the inner sidewalls, the inner sidewalls being substantially vertical, the at least one screen having a plurality of holes sized just large enough to allow nut milk to freely pass through;
a cutting device positioned within the mixing container and mounted on the shaft, the cutting device configured to be driven by the motor during operation, the cutting device comprising a central hub and at least two blades, the at least two blades vertically offset and each having a blade tip, each blade tip positioned a radial distance from the inner sidewalls of the mixing container; and
one or more mixing arms arranged within the mixing container, the one or more mixing arms configured to scrape the inner sidewalls of the mixing container;
wherein the radial distance between the inner sidewalls and each blade tip is between approximately 2.29 and 2.79 mm (0.09 and 0.11 inches);
wherein a bottom blade of the at least two blades is spaced approximately 1.02 to 1.78 mm (0.04 to 0.07 inches) from the bottom surface of the mixing container;
wherein the plurality of holes of the at least one screen are approximately 100 mesh.

US Pat. No. 10,334,985

DISPOSABLE GRILL CLEANING DEVICE

Qloud Products LLC, Orla...

1. A grill cleaning device, comprising:a main body that is constructed from a grease absorbing material and includes a top surface having an outer perimeter, a bottom surface, and a plurality of side walls extending upward along an entirety of the outer perimeter;
a handle that extends upward from a center of the top surface of the main body, said handle being positioned equidistantly between the plurality of side walls;
a first plurality of elongated channels that are disposed along the bottom surface in a first direction; and
a second plurality of elongated channels that are disposed along the bottom surface in a second direction that is not parallel to the first direction.

US Pat. No. 10,334,984

APPARATUS AND METHODS FOR MAKING BREAD

iYukti LLC, Broadlands, ...

1. An apparatus, comprising:a cooking assembly including a first platen and a second platen, the first platen having a first flattening mass and a first heating surface movably coupled to the first flattening mass, the second platen having a second flattening mass and a second heating surface, the first heating surface between the first platen and the second heating surface, the second platen coupled to the first platen such that the first heating surface and the second heating surface define a platen volume within which an ingredient mixture can be disposed; and
an actuator assembly configured to move at least one of the first platen or the second platen to reduce the platen volume to place the cooking assembly in a flattening configuration, the first heating surface and the second heating surface each configured to contact the ingredient mixture when the cooking assembly is in the flattening configuration, the first heating surface in contact with the first flattening mass and the second heating surface in contact with the second flattening mass when the cooking assembly is in the flattening configuration, the actuator assembly configured to rotate at least one of the first platen or the second platen to transition the cooking assembly between a first orientation and a second orientation, the first heating surface below the second heating surface when the cooking assembly is in the first orientation, the second heating surface below the first heating surface when the cooking assembly is in the second orientation,
the actuator assembly configured to move at least one of the first platen or the second platen to increase the platen volume to place the cooking assembly in a cooking configuration when the cooking assembly is in the first orientation, the first heating surface contacting the ingredient mixture to apply heat to the ingredient mixture when the cooking assembly is in the cooking configuration, the first heating surface being spaced apart from the first flattening mass when the cooking assembly is in the cooking configuration.

US Pat. No. 10,334,973

ADJUSTABLE AND MOUNTABLE GALLERY DEVICE

ABK INNOVATIONS LLC, Gal...

1. A gallery apparatus, comprising:a pair of main supports extending in a first direction with respect to a surface, each main support having a main support cord terminated by first and second main support terminal ends that respectively couple to surface attachments associated with the surface so as to mount the pair of main supports to the surface; and
at least one item support extending in a second direction with respect to the surface and between the pair of main supports, the at least one item support having opposed ends respectively having item support terminal ends for coupling the at least one item support to the pair of main supports,
wherein the second direction is transverse to the first direction,
wherein the at least one item support is configured to provide an attachment point to support an item for display, and
wherein each item support terminal end of the at least one item support comprises:
a cord stop having an aperture;
a button having an opening and coupled to a spring, wherein compression of the spring via application of a force on the button aligns the aperture and the opening so as to enable the main support cord of one of the pair of main supports to pass through;
a neck portion defining a channel configured to receive a terminal end of an item support cord forming the item support; and
a sleeve configured to slide over the neck portion and secure the terminal end of the item support cord within the channel.

US Pat. No. 10,334,971

ULTRAVIOLET SHADOW BOX

FINESSE DIAMOND CORP., N...

1. A box for displaying items, at least one of which is an ultraviolet-reactive item, the box being sized for insertion into a showcase, and the box comprising:a box structure for containing the items to be displayed, the structure including at least one shadowing surface, and at least one open or glazed surface;
lighting wired with the box structure and obscured by the at least one shadowing surface, the lighting including:
at least one compact ultraviolet LED assembly mounted on the extrusion, within which is disposed an LED circuit and a 365 nm ultraviolet LED diode disposed on the LED circuit, and
a controller for controlling the lighting; and
means for directing the position or orientation of the lighting so that the ultraviolet LED stimulates visible fluorescence in the ultraviolet-reactive item, while areas in the box are subject to ambient or showcase white light penetrating into the box structure through the at least one open or glazed surface; and areas in the box are subject to shadowing from the at least one shadowing surface.

US Pat. No. 10,334,969

MODULAR DISPLAY

Art Guild, Inc., West De...

1. A modular display unit comprising:at least two structural supports;
at least one separator that is positioned between and connected to the at least two structural supports; and
at least two product holders, each product holder has a forward wall, a rear wall, and a plurality of product holding slots;
the plurality of product holding slots are supported on a bulbous base that extends between the forward wall and the rear wall, and supports a dependent side wall; and,
the base and dependent side wall of the at least two product holders cooperate to define respective receiving areas that each receive a portion of a respective one of the at least two structural supports,
whereby a product is displayed in a product holding location defined by opposed slots in the at least two product holders.

US Pat. No. 10,334,968

BRACKET ASSEMBLIES FOR SIGNAGE SYSTEMS AND MERCHANDISING DISPLAY SYSTEMS

T.M. Shea Products, Inc.,...

1. A bracket assembly for suspending a merchandising display panel, the bracket assembly comprising:a generally L-shaped bracket having a first arm and a second arm, the first arm defining a planar base element;
first and second securing elements including first and second suction cups, respectively, and first and second attachment portions, respectively, the first and second attachment portions passing through first and second holes, respectively, of the planar base element; and
a planar mounting element defined by the second arm and carried by the base element, the planar mounting element engaging a planar merchandising display panel, the planar merchandising display panel perpendicular to the mounting element,
wherein the first and second attachment portions extend parallel to the planar merchandising display panel, and
wherein the planar merchandising display panel is flush against the second arm.

US Pat. No. 10,334,967

MERCHANDISER AND METHODS RELATING TO SAME

Retail Space Solutions LL...

1. A product display merchandiser comprising:a support member;
an intermediate member movably attached to the support member, the intermediate member being movable between at least a retracted position and an extended position; and
a product support slidably attached to the intermediate member and movable between at least a retracted display position and an extended stocking position;
wherein the intermediate member has a front portion, a rear portion and a longitudinal axis extending between the front portion and the rear portion, and the product support is slidable along the longitudinal axis or an axis parallel to the longitudinal axis so that the product support extends out relative to the front portion of the intermediate member beyond a generally vertical plane containing the front portion of the intermediate member when the product support is in the extended stocking position.

US Pat. No. 10,334,964

HOLDER ASSEMBLY

INVENTORY SYSTEMS GMBH, ...

1. A holder assembly for hanging goods to be displayed at a point of sale, comprising:at least one elongated holding member at which goods are to be hanged and to be arranged in a row of goods one behind the other so that the hanging goods may be slid along the at least one elongated holding member to a removal position at an end of the at least one elongated holding member where a good may be removed from the at least one elongated holding member; and
a carrier to which the at least one elongated holding member is mounted and at which an electronic detection element is provided,
wherein the at least one elongated holding member is displaceable between a first position and a second position with a motion component in the vertical direction,
wherein the at least one elongated holding member is configured to be displaced from the first position to the second position in order to allow a removal of at least one foremost good of a row of hanging goods arranged at the at least one elongated holding member from the at least one elongated holding member so that the at least one elongated holding member is displaced from the first position to the second position every time one good is removed from the at least one elongated holding member, and
wherein the electronic detection element is configured to detect a displacement of the at least one elongated holding member from the first position to the second position for emitting at least one signal every time one good is removed from the at least one elongated holding member.

US Pat. No. 10,334,957

MATTRESS ARRANGEMENT, SUCH AS A BED, HAVING ZONES WITH ADJUSTABLE HEIGHT/FIRMNESS

STARSPRINGS AB, Herrljun...

1. A mattress arrangement, comprising:an upper mattress;
a lower mattress beneath said upper mattress, the lower mattress having a same width as the upper mattress; and
a support structure beneath the upper mattress, the support structure including at least one flexible elongate element extending between two holding elements at opposite sides of at least one variable zone in said mattress arrangement,
wherein said holding elements are between the lower mattress and the upper mattress;
wherein the upper mattress is a pocket spring mattress including coil springs in separate pockets of a cover material, the cover material enclosing the upper mattress, and further includes a retraction device configured to control a slack of said flexible elongate element(s) by controlling a length of the flexible elongate element(s) between said holding elements, thereby controlling a height and/or firmness of the mattress arrangement in said variable zone(s); and
wherein the retraction device is configured to retract the flexible elongate element(s) by at least one of rolling up the flexible elongate element(s) around an axle, pulling an end of the flexible elongate element(s), and pushing an end of the flexible elongate element(s).

US Pat. No. 10,334,949

SYSTEM FOR FIXATION OF SHELF ACCESSORIES TO A SHELF

HL Display AB, Nacka Str...

1. System for fixation of shelf accessories to a shelf, the system comprising;an elongate front fixation device (120, 220, 320, 420,) having a longitudinal direction and being arranged to be fixed to a shelf (10), at or adjacent and in parallel with a front edge (11) of said shelf, said front fixation device comprising at least one channel wall (123, 223, 323, 423) defining a longitudinally extending, open engagement channel (124, 224, 324, 424), and
at least one shelf accessory (140, 240, 340, 440, 640) arranged to be supported on an upper surface of the shelf and comprising an engagement member (150, 250, 350, 450, 650) arranged to be brought into engagement with said channel wall, for fixation of the shelf accessory to the front fixation device and the shelf, whereinthe shelf accessory comprises a resilient member (158, 258, 358, 458, 441a, 600) arranged to press the engagement member into an engaged position at which the engagement member is in engagement with the channel wall and to allow the engagement member to be brought to a disengaged position at which the engagement member is disengaged from the channel wall by deformation of the resilient member, the resilient member is arranged to contact the front fixation device both in the engaged position and in the disengaged position of the engagement member.

US Pat. No. 10,334,948

ELECTRIC SHELF

Loctek Inc., Livermore, ...

16. An electric shelf, comprising:at least one column to be installed on a wall;
a slidable component arranged on the column to slide along the column vertically;
at least one layer of shelf board component connected to the slidable component to move simultaneously with the slidable component; and
a linear driving device connected to the slidable component and the colunm to actuate the slidable component to move relative to the column;
wherein the column is an interior tube fixed to the wall, and the slidable component is an exterior tube mounted outside the interior tube;
wherein each shelf board component comprises a frame and a board body, a frame connector is arranged between the frame and the exterior tube, the frame connector encircles the exterior tube near a central section of the frame connector, and the two ends of the frame connector are fixed to the frame.

US Pat. No. 10,334,946

MOVABLE CABINETS

CABINETICS INNOVATIONS LT...

1. A Highly Hung Vertically Moveable Cabinet (HHVMC), comprising:a cabinet having a bottom and a top essentially parallel thereto;
an electrical motion system including:
a first bracket configured for attachment to a ceiling,
a second bracket configured for attachment to said ceiling independently of said first bracket and
an electric tubular motor for wrapping a curtain attached between the cabinet and said first bracket; said electrical motion system configured to move the cabinet to a predetermined distance of at least 500 mm in a first direction and in a second opposite direction, both first direction and second direction being essentially normal to the bottom and top;
a retractable belt configured to remain attached between the cabinet and said second bracket independently from said tubular motor; said retractable belt passively extending and retracting as said cabinet is lowered and raised respectively;
a brake attached to said retractable belt to stop said extending in response to a sudden increased movement; and
switches coupled to the electrical motion system, to allow selection of movement in the first or second direction.

US Pat. No. 10,334,940

COMPOSITE HEAD TOOTHBRUSH HAVING SAFETY FEATURES

Loops LLC, Ferndale, WA ...

1. A toothbrush having a composite head, the composite head comprising:a rigid polymer inner core having a plurality of bristle holes for retention and holding a plurality of toothbrush bristles, the rigid inner core made from a 1st material;
a pliable flexible material completely surrounding the rigid inner core on a left and a right side in bottom plan view underside aspect, the pliable flexible material being made from a 2nd material; and
a bond at an interface between the rigid inner core and the pliable flexible material surrounding the rigid polymer inner core, wherein further the rigid polymer inner core is molded to the pliable flexible material thereby forming the composite head having the bond.

US Pat. No. 10,334,938

PERSONAL ITEM MANAGEMENT APPARATUS

THE BIG O, LLC, Dallas, ...

1. A personal management apparatus, comprising:a wearable band having a non-adjustable, fixed circumference that defines a first outer diameter; and
a clasp coupled to the wearable band, the clasp defining a second outer diameter that is less than the first outer diameter and being adapted to couple a personal item to the wearable band;
wherein the wearable band comprises:
an inner core formed from a rigid or non-flexible material, the inner core being ring-shaped; and
a cover surrounding the inner core, the cover defining an outer surface;
wherein a portion of the inner core of the wearable band is radially sandwiched between radially-spaced first and second portions of the outer surface of the cover of the wearable band;
wherein the first portion of the outer surface of the cover of the wearable band defines the first outer diameter;
wherein the second portion of the outer surface of the cover of the wearable band is generally circular in shape, and is sized so that the wearable band is adapted to be worn around a user's wrist and/or bicep;
wherein the outer surface of the cover of the wearable band extends continuously and uninterruptedly along the fixed circumference of the wearable band in its entirety;
wherein the outer surface of the cover of the wearable band is generally donut-shaped and defines a radially-extending cross-section, the radially-extending cross-section generally defining a circular shape that is constant and the same at any point along the fixed circumference of the wearable band and throughout the outer surface's continuous and uninterrupted extension along the fixed circumference of the wearable band in its entirety;
wherein the circular shape, which is generally defined by the radially-extending cross-section defined by the outer surface of the cover of the wearable band, is coplanar with the any point along the fixed circumference of the wearable band, and extends radially outward from the second portion of the outer surface of the cover to the first portion of the outer surface of the cover at the any point along the fixed circumference of the wearable band, the circular shape being radially bounded by the second portion of the outer surface of the cover and the first portion of the outer surface of the cover;
wherein the clasp comprises:
a clasp body forming an arcuate shape that defines the second outer diameter; and
a gate movable between a closed position and an open position, the gate having a first end pivotably coupled to one end of the clasp body and an opposing second end that moves relative to another end of the clasp body;
wherein, when the gate of the clasp is in the closed position, the opposing second end of the gate is locked to the another end of the clasp body;
wherein, when the gate of the clasp is in the open position, the opposing second end of the gate extends towards the clasp body;
wherein the gate of the clasp is spring loaded so that:
the gate of the clasp is biased into the closed position; and
the gate of the clasp is configured to be moved from the closed position to the open position in response to an application of a force against the gate;
wherein, when the gate is in the open position and the application of the force against the gate is released, the gate of the clasp self locks by moving from the open position to the closed position in which the opposing second end of the gate is locked to the another end of the clasp body;
wherein the opposing second end of the gate and the another end of the clasp body are configured so that an audible click is heard when the gate obtains the closed position in which the opposing second end of the gate is locked to the another end of the clasp body;
wherein a first inner region is defined by the cover of the wearable band;
wherein the first inner region is generally circular in shape;
wherein the clasp extends through the first inner region so that the wearable band extends around a portion of the clasp;
wherein a second inner region is at least partially defined by the clasp body of the clasp;
wherein the wearable band extends through the second inner region so that the clasp extends around a portion of the wearable band when the gate of the clasp is in the closed position;
wherein the extension of the clasp through the first inner region, and the extension of the wearable band through the second inner region, couples the clasp to the wearable band;
wherein the extension of the clasp through the first inner region, the extension of the wearable band through the second inner region, and the continuous and uninterrupted extension of the outer surface along the fixed circumference of the wearable band in its entirety, permits movement of the clasp relative to the wearable band and along the fixed circumference of the wearable band in its entirety, while the clasp remains coupled to the wearable band;
and
wherein at least the rigidity of the rigid or non-flexible material from which the inner core of the wearable band is formed is such that, when the personal item is coupled to the wearable band by the clasp and the personal item applies a gravity-induced load against the wearable band:
the first outer diameter of the wearable band remains generally constant;
the circular shape of the first inner region is generally maintained; and
since the first outer diameter of the wearable band remains generally constant and the circular shape of the first inner region is generally maintained, the clasp continues to be permitted to move relative to the wearable band and along the fixed circumference of the wearable band in its entirety, while the clasp remains coupled to the wearable band and the personal item is coupled to the clasp.

US Pat. No. 10,334,935

ONE-TOUCH COMPACT CASE HAVING REFILLABLE STRUCTURE

CTK CO. LTD., Seongnam-s...

1. A one-touch compact case having a refillable structure that includes a lower body and an upper cover unit having a cover and a lid inside the cover, the lower body and the upper cover unit being divided into halves and combined up and down, and in which predetermined sides of the lower body and the upper cover unit are combined by a pin and other sides are locked and unlocked by a locking unit so that the upper cover unit is opened and closed from a top of the lower body,wherein the upper cover unit is combined with or separated for refilling from the lower body, through the pin inserted into pin holes formed through ribs at predetermined sides of the cover and the lid and put into or out of a pin groove open downward at a rib at a side of the lower body, and the lower body receives and packs a cosmetic,
wherein a top of a storage space is hermetically closed by a cut plate having a circular cut line and a ring for cutting on a top and a bottom of the storage space is open and hermetically closed through a bottom plate that is hermetically bonded after the cosmetic is received in the storage space so that the cut plate is pulled with the ring for use in a single motion.

US Pat. No. 10,334,932

LIGHTENING COSMETIC CONTAINER

HUANIYA INTERNATIONAL CO....

1. A lightening cosmetic container, including:a main body, including a case, a cover and an attachment member, the cover having an inner surface including at least one recession disposed thereon, the attachment member being attached to the inner surface by an adhesive material and covering at least part of the at least one recession within which the adhesive material comes;
a lightening device, disposed on the main body, including at least one light source, a magnetic switch which is electrically connected with the at least one light source, and a magnetic member disposed corresponding to the magnetic switch; wherein the cover is openable relative to the case to change magnetic state of the magnetic switch and switch the magnetic switch on.

US Pat. No. 10,334,931

PUFF-EMBEDDED COSMETIC POWDER CONTAINER

CTK CO. LTD., Seongnam-s...

1. A puff-embedded cosmetic powder container, comprising:a main body having a space to hold cosmetic powder therein;
a shoulder cap including a coupling portion through which the shoulder cap is coupled to an upper end of the main body, and a net which is secured by a coupling ring to a powder discharge hole defined in a bottom portion thereof;
a puff receiving cap including on a first side thereof a hinge unit to open or close the puff receiving cap relative to the shoulder cap, a receiving portion receiving a puff therein, and an annular packing provided on a lower portion of the bottom portion to block the powder discharge hole; and
an upper cap coupled to the main body in a threaded fastening method to open or close the main body, and pressurizing the puff receiving cap when the upper cap is coupled to the main body in the threaded fastening method, thus allowing the annular packing provided on a lower portion of the puff receiving cap to forcibly seal the powder discharge hole of the shoulder cap,
wherein a sealing step is formed on an inner circumference in the space of the main body, and a sealing wing is formed on an outer circumference of a sidewall of the shoulder cap to correspond to the sealing step, so that the sealing wing is elastically and airtightly coupled to the sealing step when the shoulder cap is coupled to the main body, and a rotary portion included in the hinge unit of the puff receiving cap has a movable space in which a second end of a pin is movable up and down, a first end of the pin being press-fitted into a pin fixing portion of the shoulder cap, so that, when the upper cap is manipulated to be closed, the puff receiving cap is pressed down via the movable space, thus sealing the powder discharge hole of the shoulder cap.

US Pat. No. 10,334,930

NAIL SANITIZER TOOL

Freshnails Sanitizer, Inc...

1. A nail cleaning and sanitizing tool comprising:a) a main body housing a wadding section to store alcohol;
b) a nail penetrating device connected to and in fluid communication with the main body, the nail penetrating device further comprising:
i. a digger comprised of a body having a proximal portion, a tapered distal portion and a protrusion extending from a first side of the body adjacent the tapered distal portion, the protrusion forming a triangle pyramid shape having one face thereof a concave cavity bound along a periphery by first and second retaining walls, where the first and second retaining walls form edges between the one face and another two faces of the triangular pyramid shape and converge at an apex of the triangular pyramid to form a nub, wherein a continuous distal edge of the digger is formed by a distal-most edge of the tapered portion, a distal-most edge of the protrusion and the nub, where the nub is adjacent and continuous with the distal-most edge of the protrusion and disposed opposite the tapered portion, and,
ii a nib, the nib having a first side and a second side joined at one end by a wall, where the first and second sides converge and terminate at a curved peripheral edge opposite the wall, and wherein the nib is in fluid communication with the wadding section and the wall of the nib is directly coupled to a second side of the body of the digger opposite the first side,
c) wherein the curved peripheral edge provides optimal contact to sanitize an under the nail region, and,
d) wherein the concave cavity and the first and second retaining walls terminating in the nub remove and collect debris from the under the nail region.

US Pat. No. 10,334,929

HAIR PRODUCT APPLICATION DEVICE

The Pro-Motion Group, LLC...

1. A hair product application device consisting of:a glove comprising a plurality of digit portions; and
a blister pack disposed on at least one digit portion from among the plurality of digit portions, the blister pack consisting of:
a pocket containing a hair product composition, the pocket located on at least a portion of an exterior surface of the at least one digit portion of the glove; and
a rupturable membrane at least partially forming the pocket and configured to release at least a portion of the hair product composition when ruptured in response to a pressure differential between an internal pressure exerted on the rupturable membrane and an external pressure exerted on the rupturable membrane.

US Pat. No. 10,334,928

CONTAINER FOR MOBILE DEVICE

Zgonic Pty Ltd., Victori...

1. A container comprising: a housing including a chamber with a side opening formed in said housing and defined by a base wall and an upper wall, and said housing including a cover panel extended from said upper wall and foldable relative to said upper wall and movable toward said upper wall, said housing including a flap extended from said base wall and foldable relative to said base wall for covering the side opening of said chamber of said housing selectively, and said housing including a depression formed in said upper wall, a lock device attached to said cover panel, a lock member attached to said flap for selectively engaging with said lock device of said cover panel and for coupling said cover panel and said flap together, a mobile device selectively receiveable and engageable into said chamber of said housing through the side opening, a base plate engaged in said base wall of said housing, a support device foldably attached to said base plate with a hinge device, and said support device being foldable relative to said base plate and said housing, and a display attached to said support device and movable relative to said upper wall between an upwardly working position and a downwardly folded storing position, and said display being selectively receivable and engageable in said depression which is formed in said upper wall of said housing when said cover panel is folded toward said upper wall.

US Pat. No. 10,334,927

LUGGAGE SYSTEM EMPLOYING A TELESCOPICALLY-EXTENDABLE HANDLE AND BATTERY POWER SUPPLY ASSEMBLY EQUIPPED WITH A SEMI-AUTOMATIC BATTERY POWER MODULE EJECTION MECHANISM

JRSK, Inc., New York, NY...

1. A luggage system comprising:front and rear housing portions hinged together to provide a housing assembly provided with a set of spinner wheels; and
a telescopically-extendable handle and rechargeable power supply assembly mounted within the rear housing portion and having a pair of spaced-apart guide tubes mounted in the rear housing portion, and supporting a pair of telescopically-extendable rods joined to a handle structure, for pulling the luggage system on the set of the spinner wheels;
wherein the telescopically-extendable handle and rechargeable power supply assembly includes
(i) a base housing component mounted in an aperture formed in the rear housing portion, and having a top surface with a power port access opening;
(ii) a battery module casing mounted to and beneath the base housing component, and disposed substantially in the same plane as and between the pair of spaced-apart guide tubes; and
(iii) a semi-automatic battery power module ejection mechanism comprising a spring-biased platform mounted at the bottom of the battery module casing, for ejecting a battery power module from the battery module casing when the finger of a user presses down on the battery power module while retained in the battery module casing so that the battery power module automatically pops up above the surface of the power port access opening, for manual removal of the battery power module from the battery module casing, wherein the spring-biased platform has multiple configurable states including:
a first lockable state where the spring-biased platform is located at a first position in the battery module casing and supports the battery power module in the battery module casing at a first depth within the battery power module where the top of the battery power module resides at or below the surface of the power port access openings; and
a second lockable state where the spring-biased platform is located at a second position in a second depth within the battery power module where the top of the battery power module resides above the surface of the power port access opening so as to allow the battery power module to be manually removed and withdrawn from the battery module casing using the fingers of the user.

US Pat. No. 10,334,924

PROTECTIVE CASING FOR ELECTRONIC PRODUCT

SHENZHEN ILLUSDESIGN CREA...

1. A protective casing for electronic product, comprising:a flexible body; and
a support assembly coupled to the flexible body and comprising:
a fixing plate;
a support arm;
a pivot assembly disposed between the fixing plate and the support arm, wherein one end of the support arm is pivotally jointed to the fixing plate using the pivot assembly, and wherein another end of the support arm is pivotable around the pivot assembly in order to be opened or closed relative to the fixing plate; and
a mounting zone disposed along a short side direction of the flexible body and configured to mount the fixing plate,
wherein two openings are symmetrically arranged in the mounting zone,
wherein a connecting plate is disposed between the two openings,
wherein one end of the fixing plate penetrates through one of the two openings from a front side of the flexible body and is snap-fitted to the flexible body,
wherein the other end of the fixing plate penetrates through the other one of the two openings from the front side of the flexible body and is snap-fitted to the flexible body, and
wherein the connecting plate abuts against the fixing plate.

US Pat. No. 10,334,923

CARRIER APPARATUS FOR GARMENTS

FirstLight Projects Londo...

1. A carrier apparatus for supporting a garment, the apparatus comprising a hanger having first and second arm elements that project radially outwardly from a central hanging axis and which are connected by a hinged coupling which allows the first and second arm elements to be folded around said central axis or axes parallel to said central hanging axis to thereby substantially overlie one another, and a garment storage bag to which the hanger is couplable, wherein the garment storage bag is configured to fold at least first and second axes, the first and second axes being substantially normal to one another, and wherein the central axis of the hanger coincides with one of said first and second fold axes of the garment storage bag,wherein the garment storage bag has one or more fastenings that couple to fastenings provided to said hanger such that the central axis of the hanger coincides with one of said first and second fold axes of the garment storage bag.

US Pat. No. 10,334,919

BRAZED JOINT FOR ATTACHMENT OF GEMSTONES TO EACH OTHER AND/OR A METALLIC MOUNT

Forever Mount, LLC., Tuc...

1. A gemstone arrangement comprising:a first non-grooved gemstone having a first mounting surface;
a second non-grooved gemstone having a second mounting surface: and
at least one braze joint, the at least one braze joint being formed from a reactive metallic alloy, the braze joint adhering the first mounting surface to the second mounting surface, the braze joint being substantially concealed from a direct line of sight from a top portion of the gemstone preventing excessive alloy from getting outside a desired braze area.

US Pat. No. 10,334,911

BUCKLE

Lindnerhof-Taktik GmbH, ...

1. A buckle for releasable load coupling of two elements comprising:a first buckle component and a second buckle component configured for releasable engagement at a coupled position;
said first buckle component having a first connection area for connecting said first buckle component to a first element of said two elements, and a first coupling area including a first hook profile extending a width direction;
said second buckle component having a second connection area for connecting said second buckle component to a second element of said two elements, and a second coupling area including a second hook profile extending in said width direction;
a locking element for releasably locking said first buckle component to said second buckle component when said first buckle component and said second buckle component are at said coupled position,
wherein said first hook profile and said second hook profile are complementary and interengage at said coupled position to couple said first buckle component to said second buckle component in a form-fit manner; and
wherein the locking engagement of said locking element in said coupled position is adapted to be released by pulling an operating element connected to said locking element.

US Pat. No. 10,334,907

BIO HEEL PAD, BIO HEEL PAD SHOE AND METHODS OF MANUFACTURING SAME

BioFoot Pad, Incorporated...

1. A shoe having a bio foot pad for insertion into the shoe, comprising:a shoe counter having a bio foot pad, wherein the bio foot pad includes a plurality of circumferential elastic fibers uniformly located in an arcuate orientation throughout a viscoelastic material such that each fiber includes first and second fiber termination ends, wherein all of the first fiber termination ends are connected together and all of the second fiber termination ends are connected together at separate locations outside of the viscoelastic material for fixation to the shoe counter;
wherein the circumferential elastic fibers react to biphasic properties of the viscoelastic material such that the biphasic properties include a non-elastic phase and an elastic phase; and
wherein the circumferential elastic fibers are configured to, under a compression of the viscoelastic material due to an interaction of a heel area of a user of the shoe with the viscoelastic material that generates the elastic phase, develop a plurality of hoop stresses that allow axial forces exerted against the heel area of the user of the shoe to be evenly distributed along the heel area of the user of the shoe.

US Pat. No. 10,334,905

HEEL-SUSPENDING PROTECTIVE BOOT

Walgreen Health Solutions...

1. A protective boot for use by a person lying in a supine position and supporting a lower leg, heel, and foot thereof, the boot comprising:a body formed of a flexible and compressible foam material, the body having a proximal leg portion, a distal forefoot portion contiguous with and projecting from the leg portion in a transverse direction thereto, a continuous cavity defined by and within the leg and forefoot portions and being complementary in size and shape to support the lower leg of the person while supporting the foot of the person in an upright position, an anterior opening defined in the leg and forefoot portions to permit the foot and lower leg to pass therethrough into the cavity within the leg and forefoot portions, oppositely-disposed lateral regions defined by the leg portion and separated by the anterior opening, oppositely-disposed lateral regions defined by the forefoot portion and separated by the anterior opening, an interior surface defined by the leg and forefoot portions within the cavity, an exterior surface defined by the leg and forefoot portions, and a continuous rim separating the interior and exterior surfaces;
a cushion within the cavity within the lower leg portion for supporting the lower leg of the person and suspending the heel of the person within the cavity;
a first low-friction material defining the exterior surface at the leg and forefoot portions;
a trim being a second low friction fabric at the continuous rim separating the interior and exterior surfaces, the second low-friction fabric trim being a different material than the first low-friction material defining the exterior surface of the body and being sewn onto the body so as to form the continuous rim in its entirety by compressing and narrowing the foam material of the body along the entire perimeter of the anterior opening;
first means for adjustably closing the anterior opening in the leg portion with the lateral regions of the leg portion; and
second means for adjustably closing a portion of the anterior opening in the forefoot portion with the lateral regions of the forefoot portion by drawing the lateral regions of the forefoot portion inward and toward the medial and lateral sides of the foot of the person within the forefoot portion without applying pressure to the dorsum of the foot.

US Pat. No. 10,334,901

EMERGENCY HAIR WEAVE KIT

Anita Lucille Brooks, Oa...

1. A hair weaving kit comprising:a hair cap having a top side and a bottom side;
a plurality of pieces of precut lengths of hair with at least one first snap attached to an end of each of the plurality of pieces of precut lengths of hair; and
a plurality of mating second snaps for mating with the first snaps;
wherein there are no snaps attached to the hair cap; and
wherein the mating second snaps and the first snaps are configured to attach the plurality of pieces of precut lengths of hair to the hair cap by placing the plurality of pieces of precut lengths of hair on the top side of the hair cap, placing the mating second snaps on the bottom side of the hair cap, and locking the mating second snaps to the first snaps with the hair cap sandwiched in between such that the plurality of pieces of precut lengths of hair are attached to the hair cap.

US Pat. No. 10,334,896

CONVERTIBLE GARMENT

Peak Theory, Inc., Palo ...

1. A convertible garment comprising:a main body portion and a hood portion attached to the main body portion, the hood portion including inner and outer opposing surfaces and an interior volume formed therebetween, each of the inner and outer surfaces having opposing garment and ornamental plush toy sides, wherein the interior volume is accessible via an opening disposed on the inner surface of the hood portion; and
wherein the main body portion and hood portion are convertible between a garment configuration and a plush toy configuration, the ornamental plush toy sides of the inner and outer surfaces configured to face towards each other and form interior walls of the interior volume in the garment configuration, and the ornamental plush toy sides being invertible out of the opening such that they face away from each other in the plush toy configuration with the interior volume inverted therebetween.

US Pat. No. 10,334,894

SEALING ARRANGEMENT FOR GARMENTS

SI TECH AB, Brastad (SE)...

1. A sealing arrangement for garments to sealingly connect an annular layer and a wearable layer to said sealing arrangement, said sealing arrangement comprises a sealing device and a reinforcement clip,said sealing device comprising an annular sealing body and an annular base, said annular base comprising:
an inner annular wall portion,
an outer annular wall portion extending circumferentially around said inner annular wall portion,
a recess at least partly defined by said inner and outer annular wall portions, and
an annular sealing surface for circumferentially and sealingly connecting said annular layer to said annular base;
said annular sealing body being adapted to be locked into said recess to circumferentially and sealingly connect said wearable layer between said annular base and said annular sealing body;
said reinforcement clip comprising a sealing device locking portion arranged at a first end portion of said reinforcement clip, a counter acting portion arranged at a second end portion of said reinforcement clip, and a connecting portion connecting said sealing device locking portion and said counter acting portion;
wherein said sealing device locking portion is arranged to be locked to at least one of said inner annular wall portion and said outer annular wall portion of said sealing device and said counter acting portion is configured to, in use, counter act a relative movement of the outer and inner annular wall portions whereby the risk of said annular sealing body to be released from said recess is reduced,
wherein said counter acting portion comprises a base sub portion connected to said connecting portion, and a main protruding portion extending from said base sub portion at least partly in the same direction as said connecting portion, thereby forming a main reinforcement clip recess defined by at least a part of said connecting portion, at least a part of said base sub portion and at least a part of said main protruding portion.

US Pat. No. 10,334,892

CHEST WALL ADAPTER DEVICE AND METHOD OF USE

Hubbard Innovations, Inc....

1. A chest wall adapter apparatus for supporting a user's breasts, the apparatus having left and right sections and comprises:a horizontally extending and upwardly angled shelf configured to extend along and follow a contour along at least an underside of the breasts of the user;
a vertically extending adapter wall, having an inner face and an outer face, a top of the vertically extending adapter wall is integrally formed with the shelf and defines a curved edge corresponding to an inframammary fold of the breasts of the user, the inner face is configured to lie against the user's chest wall beneath the breasts of the user, and
an inwardly extending convex portion located midway of the left and right sections which is configured to lie against the chest wall of the user between the breasts.

US Pat. No. 10,334,889

ATHLETIC WEAR NURSING BRA

Just Bloomed, LLC, Media...

1. A nursing top for woman comprising:an inner layer and an outer layer,
the outer layer comprising shoulder straps,
the inner layer comprising a built in bra,
bra straps that connect the bra to the outer layer of the top, wherein an attachment mechanism is configured to hold and release the bra straps, wherein the bra straps are separate from the shoulder straps, wherein another mechanism is configured to adjust and release the shoulder straps,
an inner lining on the bra, the inner lining configured to be non-chafing and absorbent, and
a supporting elastic band encircling a bottom edge of the bra.

US Pat. No. 10,334,888

ELECTRONIC VAPORIZING DEVICE FOR VAPORIZING WATER-BASED COMPOSITIONS

LunaTech, LLC, Encino, C...

1. A personal vaporizer comprising:a device processor operable for controlling the personal vaporizer, wherein the device processor is operable to generate an activation command to initiate a vaporization process;
at least one container configured to store a water-based vaporizable liquid composition;
an ultrasonic vaporizing component operatively coupled to the device processor and controlled in part by the device processor, wherein the ultrasonic vaporizing component is in fluid communication with the at least one container for receiving at least a portion of the selected amount of the vaporizable liquid composition from the at least one container, wherein the ultrasonic vaporizing component comprises an ultrasonic vibration element operable to produce ultrasonic vibrations to vaporize at least a portion of the vaporizable liquid composition received therein;
a vapor outlet coupled to the ultrasonic vaporizing component and configured to receive a vapor generated by the ultrasonic vaporizing component, the vapor outlet operable to expel the generated vapor from the ultrasonic vaporizing component;
an input/output device operatively coupled to the device processor; wherein the input/output device is configured to receive a plurality of data for transmission to the device processor, wherein the input/output device is configured to transmit a plurality of data generated by the device processor; and
a power source operatively coupled to the ultrasonic vaporizing component, wherein the at least one power source is operable to generate a supply of power for operation of the ultrasonic vaporizing component;
wherein the device processor is further operable to,
receive a plurality of device activation parameters for controlling activation of the vaporization process;
generate at least one device activation control signal in accordance with at least a portion of the plurality of device activation parameters; and
transmit the at least one device activation control signal to the ultrasonic vaporizing component to initiate the vaporization process in accordance the at least one device activation control signal.

US Pat. No. 10,334,886

ATOMIZER AND ELECTRONIC CIGARETTE THEREOF

Changzhou Patent Electron...

1. An atomizer, comprising: a smoke channel, an atomizer head and a collecting container, wherein an end of the smoke channel is in fluid communication with the atomizer head, the collecting container is detachably provided in the smoke channel, and the collecting container comprises a collecting cavity and an air outlet in fluid communication with two ends of the smoke channel; the collecting cavity has a closed end near the atomizer head and an open end away from the atomizer head, and the open end of the collecting cavity is in fluid communication with a channel wall of the smoke channel located above the open end of the collecting cavity.

US Pat. No. 10,334,881

ELECTRONIC VAPORIZER

FUMA INTERNATIONAL, LLC, ...

1. An apparatus comprising:a power source,
wherein the power source includes a battery,
wherein the power source includes an electrically conductive portion; and
a cartridge having a housing that comprises an interior,
wherein the housing includes a first end and a second end that is opposite the first end, wherein the housing includes a first aperture on the first end and a second aperture on the second end,
wherein the housing includes an airflow passageway that extends centrally and axially with respect to the housing intermediate of the first aperture on the first end of the housing and the second aperture on the second end of the housing,
wherein the airflow passageway is configured to allow an airflow through the cartridge from the first aperture to the second aperture of the housing,
wherein the first end of the housing includes an electrically conductive portion that is adapted to mechanically and electrically couple to the electrically conductive portion of the power source,
wherein the housing includes a solution holding medium adapted to hold a solution in the interior of the housing,
wherein the housing includes a heating element located in the interior of the housing, wherein the heating element extends transversely across the airflow passageway, wherein the airflow through the passageway passes on both transverse sides of the element,
wherein the solution holding medium surrounds the airflow passageway and the heating element in the interior of the housing and intermediate of the first end and the second end,
wherein the heating element is electrically configured to vaporize at least a portion of the solution to be contained in the solution holding medium for oral provision to an individual in an airflow from the second aperture responsive to electrical power received from the battery through the electrically conductive portions of the cartridge and the power source.

US Pat. No. 10,334,878

HANDHELD VAPORIZING DEVICE

NURYAN HOLDINGS LIMITED, ...

1. A handheld electronic vaporizing device, comprising:a body defining a first cavity;
a mouthpiece connected to said body, said mouthpiece defining a second cavity;
an electroconductive textile heating element;
a deformable reservoir;
a power element;
a power connect element;
a capacitive touch sensor element;
a light element;
a first opening and a first valve located on a wall of said body to provide for a flow of air directly into said first cavity, wherein said first valve is normally closed and is opened by said flow, wherein said flow includes only air as said flow passes into said first cavity, and wherein said first opening includes a first opening area and said flow upon passing through said first opening and said first valve directly into said first cavity has a first velocity;
a second opening and a second valve connecting said first cavity and said second cavity, wherein said second valve is normally closed and is opened by said flow, wherein said flow passes from said first cavity through said second opening and said second valve and into said second cavity, wherein said flow causes said first valve and said second valve to be open at the same time, and wherein said second opening includes a second opening area greater than said first opening area and said flow after passing through said second opening has a second velocity, said first velocity being greater than said second velocity; and
a third opening disposed through a wall of said mouthpiece, wherein said electroconductive textile heating element, said reservoir, said power element and said power connect element are disposed inside said first cavity, and wherein said first velocity of said flow contributes to mixing said flow with a vapor in a space adjacent to said electroconductive textile heating element.

US Pat. No. 10,334,874

METHOD FOR PRODUCING MICROCRYSTALLINE CELLULOSE FROM TOBACCO AND RELATED TOBACCO PRODUCT

R. J. Reynolds Tobacco Co...

1. A dissolving grade pulp derived from tobacco, the dissolving grade pulp characterized by a brightness of at least about 83%, an alpha-cellulose concentration of at least about 88% by weight, a beta and a gamma cellulose content, and a degree of polymerization of about 100 to about 750, wherein the dissolving grade pulp is characterized by a kappa number between about 20 and about 30.

US Pat. No. 10,334,868

SYSTEM FOR PROVIDING A SINGLE SERVING OF A FROZEN CONFECTION

Sigma Phase, Corp., Lexi...

1. A method for providing a single serving of a frozen confection, the method comprising:inserting a pod containing one or more ingredients and a mixing paddle into a recess of a machine for providing the single serving of the frozen confection;
contacting a side wall of the pod against a side wall of the recess;
connecting a motor of the machine to a stem of the mixing paddle, the stem extending through an end wall of the pod;
rotating the mixing paddle inside the pod in a first direction while cooling the recess to form the frozen confection from the one or more ingredients; and
rotating the mixing paddle inside the pod in a second direction opposite the first direction to dispense the frozen confection from the pod into an edible cone or a collecting container while the pod is in the recess of the machine without the frozen confection coming into contact with another object exterior to the pod.

US Pat. No. 10,334,864

GRAIN MANAGEMENT BASED ON GROWING CHARACTERISTICS

IntelliFarms, LLC, Archi...

1. A system comprising:one or more processors; and
a non-transitory computer-readable medium comprising instructions stored therein, which when executed by the one or more processors, cause the one or more processors to perform operations comprising:
receiving data associated with a grain mass;
receiving at least one growing characteristic of grain in the grain mass, the growing characteristic being representative of a characteristic of the grain at or prior to a time of harvest of the grain;
determining a desired grain conditioning operation for the grain mass based at least on the data associated with the grain mass and the at least one growing characteristic; and
sending a signal representative of the desired grain conditioning operation to control grain conditioning equipment.

US Pat. No. 10,334,860

DOUGH STRETCHER

Somerset Industries, Inc....

1. A dough stretcher comprising:(a) a drive shaft mounted to rotate on a vertical system axis;
(b) a mechanism for rotating the drive shaft at a speed in the range of between 40 RPM and 100 RPM;
(c) a lower platen shaft having a bottom end, a top end, and an axis, the bottom end attached to the drive shaft and extending upwardly such that the lower platen shaft axis is at a tilt angle from the system axis in the range of from 1° to 4°;
(d) a lower platen with a top surface and a bottom surface, the bottom surface rotatably attached to the top end of the lower platen shaft such that the lower platen top surface rotates perpendicularly about the lower platen shaft axis; and
(e) an upper platen with a flat bottom surface and a center, the upper platen mounted above the lower platen to reciprocate vertically with the upper platen center on a system axis.

US Pat. No. 10,334,847

ANTIFUNGAL COMPOSITION

THE UNIVERSITY OF SUSSEX

1. An antifungal composition comprising an antifungal agent and a compound of formula I:—wherein R1 is CHO or CN;R2 is a hydroxyl group;
R3 is a branched alkylene with 4 to 12 C atoms;
R4 is a hydroxyl group;
R5 is a halogen group; and
R6 is a methyl group;
wherein the antifungal agent is Azoxystrobin, and the compound of formula I can synergize with the Azoxystrobin to treat a fungal infection.

US Pat. No. 10,334,845

OLFACTORY LIGANDS

UNIVERSITY COELLEGE CARDI...

1. A (S)-germacrene D analogue of general formula (I):
wherein
R1 is H, methyl, ethyl, n-propyl, iso-propyl or cyclopropyl;
R2 is methyl;
R3 is methyl;
R4 is H, methyl, ethyl, n-propyl, iso-propyl or cyclopropyl;
R5 is H, methyl, ethyl, n-propyl, iso-propyl or cyclopropyl.

US Pat. No. 10,334,840

BIRD ANTI-COLLISION WINDOW FILM

ARTSCAPE INC., Portland,...

1. A bird anti-collision film, comprising:a polymeric film having a first side configured to attach to a window;
a discontinuous textured layer forming a raised surface on a second side of the polymeric film and exposing a portion of the polymeric film, the textured layer configured to disrupt reflections of habitat from the window; and
a fluorescent dye mixed into only the textured layer that absorbs a first light wavelength range substantially detectable by birds and substantially undetectable by humans and fluoresces at a second light wavelength range substantially detectable by birds and only partially detectable by humans,
wherein the textured layer forms spaced apart raised rounded line patterns in a cross-hatched textured pattern on the polymeric film configured to absorb the first light wavelength range and radiate out the second light wavelength range from a substantially flat front surface and rounded side and back surfaces.

US Pat. No. 10,334,836

INSECT TRAP AND METHOD OF MAKING SAME

Willert Home Products, In...

1. An insect trap comprising:a flexible bag having a first edge and a second edge that are connected together at a seam; and
a nozzle secured between the edges adjacent the seam, wherein the nozzle comprises a tube defining a passageway for insects into the bag and a fin providing a transition for the edges extending over the tube from the seam.

US Pat. No. 10,334,832

BOWFISHING REEL

Joshua Noble, Las Vegas,...

1. A bowfishing reel, comprising:a housing comprising a generally cylindrical first portion having an aperture disposed about a center top portion of the cylindrical first portion, wherein the housing comprises a generally cylindrical second portion disposed about a bottom of the first portion and wherein the second portion of the housing has an outer perimeter that is less than an outer perimeter of the first portion of the housing and wherein a bottom of the second portion is substantially planar;
a crank arm disposed about a side of the housing, said crank arm comprising a mount that is disposed perpendicular to a longitudinal axis of the housing;
a handle disposed about the bottom of the second portion, said handle comprising a post disposed coaxial with a center of the aperture and further comprising a grip coupled to a distal end of the post and disposed perpendicular to the post, wherein the grip comprises a front and a back, the front having a radius of curvature equivalent to a radius of curvature of the back; and
wherein the crank arm is mounted on a first side of the housing, the reel further comprising a fastener disposed on a second side of the housing and coaxially with the mount of the crank arm.

US Pat. No. 10,334,828

CO-LOCATION OF A HEAT SOURCE COOLING SUBSYSTEM AND AQUACULTURE

DeepWater Desal LLC, Mos...

1. A system comprising:(a) a heat source comprising a water cooling subsystem configured to receive cool water from an ocean or sea and output warm water; and
(b) an aquaculture center co-located with the heat source and comprising:
a water temperature control subsystem configured to receive the output warm water;
a tank holding aquatic organisms and water; and
a water discharge for discharging water from the aquaculture center,
wherein the aquaculture center is located on land.

US Pat. No. 10,334,827

AQUARIUM WITH NIGHT LIGHT

PetSmart Home Office, Inc...

1. An aquarium apparatus comprising: a base including a central portion, one or more lighting elements disposed in the central portion, and a raised ridge disposed on at least a segment of a periphery of the central portion; a bowl including a body portion, a bottom portion connected to the body portion, and a neck portion at a top of the bowl defining a first opening at the top of the bowl, wherein the bowl is configured to retain liquid therein, wherein the bottom portion is dimensioned to fit within the raised ridge when the bowl is placed on top of the base; a lid dimensioned to fit over the first opening at the top of the bowl, wherein the lid comprises a planar surface with a central aperture defining an inner edge portion, wherein a horizontal ledge section is connected to the inner edge portion, wherein the horizontal ledge section is connected to a downwardly extending portion that surrounds the central aperture; and a hollow member removably or fixedly attached to the downwardly extending portion, wherein the hollow member extends into the bowl substantially towards the bottom of the bowl and aligns over the one or more lighting elements, and wherein the hollow member is dimensioned to receive light emitted by the one or more lighting elements when the lid is placed on top of the bowl, wherein the light emitted by the one or more lighting elements passes through the hollow member.

US Pat. No. 10,334,817

ANIMAL BED HAVING DUAL INDEPENDENT SUPPORT CHAMBERS

Advanced Comfort Technolo...

1. A bed for at least one animal comprising:a first chamber provided between a first belt and a second belt and configured to receive liquid, and a second chamber provided between the first belt and the second belt and configured to receive liquid, wherein the first and second chambers are fluidly isolated from one another and are each configured to support and/or float a pressure point of livestock.

US Pat. No. 10,334,815

ANIMAL ENCLOSURE

Edmonds Outdoors, LLC, B...

1. A portable animal enclosure apparatus, comprising:a kennel body having a front side, a back side, a top side and a bottom side;
a door positioned on the front side of the kennel body;
a first wheel disposed on the kennel body positioned to rotate about a fixed first wheel axis, the first wheel having a first wheel radius, the first wheel protruding from the bottom side of the kennel body a first wheel bottom distance, and protruding from the back side a first wheel back distance;
a second wheel disposed on the kennel body positioned to rotate about a fixed second wheel axis co-axially aligned with the first wheel axis, the second wheel having a second wheel radius, the second wheel protruding from the bottom side of the kennel body a second wheel bottom distance, and protruding from the back side a second wheel back distance;
a first foot, a second foot, a third foot and a fourth foot each attached to the kennel body, each of the first, second third and fourth feet protruding from the bottom side of the kennel body a foot bottom distance;
wherein the foot bottom distance is greater than the first wheel bottom distance and the second wheel bottom distance,
wherein each of the first foot, second foot, third foot and fourth foot is dimensioned to elevate the bottom side of the kennel body a distance equal to the foot bottom distance above a reference planar flat resting surface on which the apparatus may rest,
wherein the first and second wheels are positioned a first clearance height above the flat resting surface when the kennel body is level such that the first, second, third and fourth feet engage the flat resting surface but the first and second wheels do not engage the flat resting surface, and
wherein the first and second wheels advance downwardly toward and engage the flat resting surface when the front side of the kennel body is tilted upwardly at an angle relative to the flat resting surface.

US Pat. No. 10,334,796

METHODS AND SYSTEMS OF CULTIVATION

MJ Brain Bank, LLC, Denv...

1. A method of cultivating cannabis hydroponically, the method comprising:placing a first cannabis plant of a plurality of cannabis plants in a first tray of a plurality of trays;
placing a second cannabis plant of the plurality of cannabis plants in a second tray of the plurality of trays, wherein:
the first tray is disposed on a first shelf of a first rack system,
the second tray is disposed on a second shelf of the first rack system,
the first shelf is at a first height,
the second shelf is at a second height, and
the first height is different from the second height;
flowing a first nutrient mixture from a first nutrient reservoir to the plurality of cannabis plants;
returning a portion of the first nutrient mixture to the first nutrient reservoir after flowing the first nutrient mixture to the plurality of cannabis plants;
exposing the plurality of cannabis plants to a first artificial light source having a first limited spectrum;
growing on the first rack system each cannabis plant of the plurality of cannabis plants without producing flowers;
transporting the plurality of trays from the first rack system to a second rack system;
flowing a second nutrient mixture from a second nutrient reservoir to the plurality of cannabis plants;
exposing the plurality of cannabis plants to a second artificial light source having a second limited spectrum, wherein the first limited spectrum comprises a different wavelength range than the second limited spectrum; and
growing flowers on each cannabis plant of the plurality of cannabis plants on the second rack system.

US Pat. No. 10,334,794

IRRIGATION IMPLEMENT

Millbrook Capital Managem...

1. A method of irrigating crops, comprising:attaching an irrigation tube to a singular tubular member consisting of:
a first end; and
a second end opposite the first end along a longitudinal axis of the member, the second end includes a heated pinched seal,
the member further defining a circular first opening disposed entirely along a longitudinal-oriented portion of a sidewall toward the second end,
wherein the first end defines a second opening having the same inner diameter as the inner diameter of the member extending between the first opening and the first end along the longitudinal axis;
the attachment causing the first opening to be sealed by the irrigation tube; and
providing water from the irrigation tube via the first opening to the member such that water free-flows from the second end to the first end into the ground to irrigate roots of the crops.

US Pat. No. 10,334,791

CONTAINER SYSTEMS AND METHODS FOR CONTROLLING PLANT GROWTH

Michael Newton, Laguna N...

1. A container system configured to control the growth of a plant, the container system comprising:a bottom section configured to accommodate and control the growth of a root part of the plant;
a middle section configured to accommodate and guide the growth of a stem part of the plant, wherein the middle section comprises a spiral part having a plurality of removable wall pieces that are bonded together to form a hollow spiral tunnel that is configured to guide the growth of the stem part along a spiral route in a spiral shape, and wherein the removable wall pieces shield the stem part of the plant from a light source; and
a top section configured to guide the growth of a vegetative part, a reproductive part or both of the plant.

US Pat. No. 10,334,773

SEED DISPENSER FOR A PRECISION AUTOMATIC SOWER

MATERMACC S.P.A., San Vi...

1. A single seed dispenser (10) for an automatic sower comprising:a cover (11) to contain seeds to be distributed, coupled to
a body (12) containing a cavity (24) in communication with an aspirator of the seeds through
a conduit (22) engaged in a hole (23) formed on said body (12),
a distribution disc (13) with holes (38, 54) contained in a compartment (20) delimited by said body (12) and by said cover (11);
a driving disc (31) joined by pins (53) to said distribution disc (13), both discs being put into rotation by means of
a shaft (29) driven by an actuator to control the rotation of the distribution disc (13) and the driving disc (31); and
a selector device (14) for the seeds pivoted on an edge of the body (12), wherein
the selector device (14) comprises a plate (142) which presents, on a side thereof facing a center of said distribution disc (13), at least two toothed portions (143, 144), having teeth of different sizes, wherein said selector device (14) is kept adherent to said distribution disc (13) by a spring (145) secured with a first end to said plate (142) and with a second end pushing against said cover (11); and
a curved sector (59) is mounted against a surface of the distribution disc (13) opposite the plate (142) and is provided with protrusions (591) having an inclined surface (592) facing the distribution disc (13) at the holes (38) of the distribution disc (13).
US Pat. No. 10,335,367

USE OF SELECTED ANTICHOLINERGIC ZWITTERIONS

BODOR LABORATORIES, INC.,...

1. A method for slowing progression of myopia in a child aged from about 6 to about 18 who is afflicted therewith, said method comprising topically administering to the eyes of said child, at least once per week for a time period of at least one year, an effective amount of at least one compound selected from the group consisting of:(a) (2R, 3?R) 3-(2-cyclopentyl-2-phenyl-2-hydroxyacetoxy)-1-(carboxymethyl)-1-methylpyrrolidinium inner salt;
(b) (2R, 3'S) 3-(2-cyclopentyl-2-phenyl-2-hydroxyacetoxy)-1-(carboxymethyl)-1-methylpyrrolidinium inner salt;
(c) (2R, 1?R) 3-(2-cyclopentyl-2-phenyl-2-hydroxyacetoxy)-1-(carboxymethyl)-1-methylpyrrolidinium inner salt; and
(d) (2R, 1'S) 3-(2-cyclopentyl-2-phenyl-2-hydroxyacetoxy)-1-(carboxymethyl)-1-methylpyrrolidinium inner salt;said at least one compound being optionally administered in the form of an ophthalmic composition comprising said effective amount of said compound and a non-toxic, ophthalmically acceptable carrier.
US Pat. No. 10,340,493

SEPARATOR FOR RECHARGEABLE BATTERY AND RECHARGEABLE BATTERY INCLUDING THE SAME

Smasung SDI Co., Ltd., Y...

1. A separator for a rechargeable battery, the separator comprising:a porous substrate, and
a heat-resistant layer on at least one surface of the porous substrate
wherein the heat-resistant layer includes a compound represented by Chemical Formula 1 or a cross-linked product thereof:
(R)n1—Ar—OH  [Chemical Formula 1]
wherein, in Chemical Formula 1,
Ar is a C6 to C20 aryl group;
n1 is an integer ranging from 5 to 19;
the Rs are the same or different and are independently hydrogen, a substituted or unsubstituted C1 to C50 alkyl group, a substituted or unsubstituted C2 to C50 alkenyl group, a substituted or unsubstituted C2 to C50 alkynyl group, a substituted or unsubstituted C3 to C50 cycloalkyl group, a substituted or unsubstituted C3 to C50 cycloalkenyl group, a substituted or unsubstituted C3 to C50 cycloalkynyl group, a substituted or unsubstituted C1 to C50 alkoxy group, a substituted or unsubstituted C6 to C30 aryl group, a substituted or unsubstituted C3 to C30 heterocyclic group, a halogen atom, a hydroxy group, a cyano group, or a combination thereof; and
at least one R is a substituted or unsubstituted C2 to C50 alkenyl group.
US Pat. No. 10,334,856

NON-TOXIC PEST CONTROL COMPOSITIONS AND METHODS AND USES THEREOF

Neozyme International, In...

1. A method of controlling a population of invertebrate pests, the method comprising applying an effective amount of a pest control composition to the population of the invertebrate pests and/or one or more locations where control of the population of the invertebrate pests is desired, the composition comprising a treated, fermented yeast supernatant including bio-nutrients, minerals and amino acids, and about 1% to about 15% by weight of one or more nonionic surfactants,wherein application of the composition creates microbubbles that increase oxygen dispersion resulting in higher dissolved oxygen levels and accelerate molecular interactions that mediate cleavage of chemical bonds,
wherein the treated, fermented yeast supernatant lacks any active enzymes, activatable pro-enzymes, or any enzymatic activity,
wherein the composition lacks any active enzymes, activatable pro-enzymes, or any enzymatic activity, and
wherein the composition has a pH below 5.0.
US Pat. No. 10,336,658

PULL MAT

IFG EXELTO NV, Ghent (Zw...

1. A pull mat for tunnel composting comprising:a layer of straight, unidirectionally-oriented threads oriented in the longitudinal direction of the pull mat, the layer consisting of a multitude of straight, individual threads which are placed essentially parallel to each other in a single plane, the straight, unidirectionally-oriented threads being spaced apart from each other,
a layer of open material being a woven fabric having warp and weft threads, and
a further layer of open material being a woven fabric having warp and weft threads,
wherein the layer of open material and the further layer of open material are positioned on opposite sides of the layer of straight, unidirectionally-oriented threads, wherein the layer of open material is arranged to face a compostable material and the further layer of open material is arranged to face a floor of the composting tunnel,
wherein warp and/or weft threads of the woven fabric of said layer of open material being part of the woven fabric of said further layer of open material so that the woven fabric of said layer of open material and the woven fabric of said further layer of open material form an interconnecting woven structure sandwiching the layer of straight, unidirectionally-oriented threads, and
wherein the pull mat as an air permeability of at least 1200 l/m sec, as determined according to ISO 9237-1995 at a pressure difference of 100 Pa.
US Pat. No. 10,335,389

BERAPROST-CONTAINING PATCH

TEIKOKU SEIYAKU CO., LTD....

1. A patch comprising a pasty preparation consisting of beraprost or a pharmacologically acceptable salt thereof, a water-soluble polymer, a polyhydric alcohol, a cross-linking agent, and, optionally, one or more ingredients selected from the group consisting of:one or more pH adjusters selected from the group consisting of acetic acid, formic acid, lactic acid, tartaric acid, oxalic acid, benzoic acid, glycolic acid, malic acid, citric acid, hydrochloric acid, nitric acid, sulfuric acid, sodium hydroxide, potassium hydroxide, methylamine, ethylamine, propylamine, dimethylamine, diethylamine, dipropylamine, trimethylamine, triethylamine, tripropylamine, monomethanolamine, monoethanolamine, monopropanolamine, dimethanolamine, diethanolamine, dipropanolamine, trimethanolamine, triethanolamine, and tripropanolamine;
one or more humectants selected from the group consisting of a saccharide and a high-absorbent resin;
one or more excipients selected from the group consisting of kaolin, diatomaceous earth, hydrous silica, zinc oxide, anhydrous silicic acid, talc, titanium, bentonite, aluminum silicate, titanium oxide, aluminum metasilicate, magnesium silicate, light anhydrous silicic acid, calcium hydrogen phosphate, calcium sulfate, magnesium carbonate, and calcium phosphate;
one or more stabilizing agents selected from the group consisting of an edetate, sodium citrate, gluconic acid, a parahydroxybenzoate, and tartaric acid;
one or more surfactants selected from the group consisting of polyoxyethylene sorbitan monooleate, sorbitan monooleate, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, alkyl ether carboxylate, alkanesulfonate, fatty acid monoglyceride sulfate, fatty acid amide amine salt, and benzethonium; and
water.
US Pat. No. 10,335,390

SECNIDAZOLE FOR USE IN THE TREATMENT OF BACTERIAL VAGINOSIS

Symbiomix Therapeutics, L...

1. A method of treating bacterial vaginosis in a subject in need thereof comprising administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the therapeutically effective amount of secnidazole is an amount of secnidazole that exhibits a maximum plasma concentration (Cmax) of about 34.5 ?g/ml to about 58.3 ?g/ml, or about 17.4 ?g/ml to about 26.5 ?g/ml in the subject, wherein the microgranule formulation comprises a plurality of microgranules having a particle size in the range of 400 micrometers to 841 micrometers, and wherein secnidazole is the sole drug in the microgranule formulation.
US Pat. No. 10,336,672

SYSTEM AND METHOD FOR PRODUCING NEOPENTYL GLYCOL

ClearWaterBay Technology,...

1. A method for producing neopentyl glycol from isobutyraldehyde, formaldehyde, and hydrogen, comprising the steps of:controlling the composition of feed to a first reaction step such that a homogeneous solution is formed, where the composition of the feed to the first reaction step is controlled such that a homogeneous solution is formed by adding a solvent that is miscible with both isobutyraldehyde and water, and where the solvent is comprised of neopentyl glycol at a concentration of 10% to 30% by weight in the feed to the first reaction step;
introducing the homogeneous solution to an aldol condensation reactor in the first reaction step, where at least a portion of the isobutyraldehyde and formaldehyde undergo an aldol condensation reaction to form a reaction mixture comprising hydroxypivaldehyde, in the presence of a suitable solid catalyst;
separating excess and unreacted aldehydes from the reaction mixture and recycling the aldehydes to the aldol condensation reactor;
contacting hydroxypivaldehyde with hydrogen in a hydrogenation reactor in a second reaction step, where hydroxypivaldehyde is converted to neopentyl glycol in the presence of a suitable hydrogenation catalyst;
isolating highly pure neopentyl glycol from the reaction mixture from the hydrogenation reactor; and
recovering neopentyl glycol from the reaction mixture from the hydrogenation reactor, so that the neopentyl glycol can be recycled to the first reaction step.
US Pat. No. 10,336,677

CURCUMIN PURIFICATION

BIOPTEQ SPRL, Nandrin (B...

1. A process for purification of curcumin comprising:(i) providing a curcuminoid composition;
(ii) contacting said curcuminoid composition with a basic amino acid or an amino acid derivative to form an amino acid salt of curcumin;
(iii) separating the salt of curcumin; and
(iv) recovering purified curcumin.
US Pat. No. 10,336,934

AQUEOUS CLEANING COMPOSITION AND METHOD

WELLRENEW, LLC, Lafayett...

1. A method of removing a deposit from a hydrocarbon system, comprising the steps of:a) providing a cleaning composition comprising: about 21% to about 33% of sodium metasilicate, about 30% to about 35% of sodium percarbonate or sodium perborate, about 6.7% to about 15% of sodium tripolyphosphate or tetrapotassium pyrophosphate, about 15% to about 29% of sodium carbonate or potassium carbonate, about 1% to about 10% of ethylene diamine tetra acidic acid tetra sodium salt 1-hydroxyethylidene-1,1-diphosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, or aminotris(methylenephosphonic acid), about 0.4% to about 1.5% of an ethoxy phosphate, about 0.6% to about 2% of a surfactant polymer mixture containing an equal amount of an ethylene oxide/propylene oxide block copolymer and an ethylene oxide/propylene oxide reverse polymer, and about 0.5% to about 2% of a wetting agent selected from the group consisting of sodium alkane sulfonate, a linear C10 diphenyl oxide disulfonate, and a nonionic ethoxylated alcohol;
b) treating the hydrocarbon system containing the deposit with an aqueous cleaning fluid containing a concentration of the cleaning composition; and
c) removing the deposit with the aqueous cleaning fluid from the hydrocarbon system.
US Pat. No. 10,336,947

PROCESS FOR CONVERSION OF A HYDROCARBON FEED

SMH Co., Ltd, Bangkok (T...

1. A process for conversion of a hydrocarbon feed comprising saturated hydrocarbon compounds to olefin products comprising contacting the hydrocarbon feed with a catalyst in an oxidic form comprising metals M1, M2, M3 and M4, wherein:M1 is selected from Si, Al, Zr, and mixtures thereof;
M2 is selected from Pt, Cr, and mixtures thereof;
M3 is selected from W, Mo, Re, and mixtures thereof; and
M4 is selected from Sn, K, Y, Yb and mixtures thereof;
wherein
mass fraction of M1 is in the range of 0.1 to 0.8;
mass fraction of M2 is in the range of 0.001 to 0.2;
mass fraction of M3 is in the range of 0.001 to 0.2;
mass fraction of M4 is in the range of 0.0001 to 0.2; and
mass fraction of oxygen is in the range of 0.1 to 0.8,
wherein the olefin products include ethylene, propylene, and butenes.
US Pat. No. 10,335,412

METHOD FOR ACTIVATING AMPK AND THE USE OF ADENINE

ENERGENESIS BIOMEDICAL CO...

1. A method for treating a condition selected from the group consisting of pre-diabetes, type 2 diabetes, and metabolic syndrome, comprising administrating to a mammal in need thereof with an effective amount of adenine and/or a pharmaceutically acceptable salt thereof to thereby increase glucose uptake into a cell and thereby treat the condition, wherein the effective amount is in a range of from 0.1 mg/kg body weight to 20 mg/kg body weight.
US Pat. No. 10,336,694

METHODS FOR IMPROVED PRODUCTION OF VITAMINS D2 AND D3

NUCELIS LLC, San Diego, ...

1. A method of production of vitamin-D2 using ergosterol or a dihydroxy derivative thereof as a starting material, or production of vitamin-D3 using 7-dehydrocholesterol or a dihydroxy derivative thereof as the starting material, comprising:(a) irradiating the starting material in a solution comprising an aliphatic amine or an aromatic amine organic base with ultraviolet light to obtain a product containing pre-vitamin-D2 or pre-vitamin-D3, and
(b) heating the product to convert the pre-vitamin-D2 or pre-vitamin-D3 to vitamin D2 or vitamin D3.
US Pat. No. 10,340,030

SYSTEMS AND METHODS FOR IDENTIFYING CANCER TREATMENTS FROM NORMALIZED BIOMARKER SCORES

BostonGene Corporation, ...

1. A system, comprising:at least one computer hardware processor;
at least one database that stores biomarker information; and
at least one non-transitory computer-readable storage medium storing processor-executable instructions that, when executed by the at least one computer hardware processor, cause the at least one computer hardware processor to perform:
obtaining sequencing data about at least one biological sample of a subject known to have or suspected of having cancerous cells or pre-cancerous cells;
accessing, in the at least one database, biomarker information indicating a distribution of values for each biomarker in at least a reference subset of a plurality of biomarkers across a respective group of people, each of the plurality of biomarkers being associated with at least one therapy in a plurality of therapies, the plurality of biomarkers including a first biomarker and the biomarker information including a distribution of values for the first biomarker;
determining, using both the sequencing data and the biomarker information:
a first set of normalized scores for a first set of biomarkers associated with a first therapy in the plurality of therapies,
a second set of normalized scores for a second set of biomarkers associated with a second therapy in the plurality of therapies, and
a third set of normalized scores for a third set of biomarkers associated with a third therapy in the plurality of therapies, wherein the first set of biomarkers is different from the second set of biomarkers, and wherein determining the first set of normalized scores comprises determining a first normalized score for the first biomarker using the distribution of values for the first biomarker at least in part by:
determining an un-normalized score for the first biomarker using the sequencing data,
determining a Z-score based on the first distribution of values for the first biomarker, and
determining a normalized score for the first biomarker based on the un-normalized score and the Z-score;
determining, using the first, second, and third sets of normalized scores and a statistical model, respective first, second, and third therapy scores for the first, second, and third therapies;
generating a graphical user interface (GUI), wherein the GUI comprises:
a first portion associated with the first therapy in the plurality of therapies, the first portion including a first plurality of GUI elements, each of the first plurality of GUI elements being associated with a respective biomarker in the first set of biomarkers and having at least one visual characteristic determined based on a normalized score of the respective biomarker in the first set of normalized scores;
a second portion associated with the second therapy in the plurality of therapies, the second portion including a second plurality of GUI elements different from the first plurality of GUI elements, each of the second plurality of GUI elements being associated with a respective biomarker in the second set of biomarkers and having at least one visual characteristic determined based on a normalized score of the respective biomarker in the second set of normalized scores; and
a third portion associated with the third therapy in the plurality of therapies, the third portion including a third plurality of GUI elements, each of the third plurality of GUI elements being associated with a respective biomarker in the third set of biomarkers and having at least one visual characteristic determined based on a normalized score of the respective biomarker in the third set of normalized scores; and
displaying the generated GUI.
US Pat. No. 10,340,031

SYSTEMS AND METHODS FOR IDENTIFYING CANCER TREATMENTS FROM NORMALIZED BIOMARKER SCORES

BostonGene Corporation, ...

1. A system, comprising:at least one computer hardware processor;
at least one database that stores biomarker information; and
at least one non-transitory computer-readable storage medium storing processor-executable instructions that, when executed by the at least one computer hardware processor, cause the at least one computer hardware processor to perform:
obtaining sequencing data about at least one biological sample of a subject known to have or suspected of having cancerous cells or pre-cancerous cells;
accessing, in the at least one database, biomarker information indicating a distribution of values for each biomarker, across a respective group of people, in at least a reference subset of the plurality of biomarkers, each of the plurality of biomarkers being associated with at least one therapy in a plurality of therapies, the plurality of biomarkers including a first biomarker and the biomarker information including a distribution of values for the first biomarker;
determining, using both the sequencing data and the biomarker information:
a first set of normalized biomarker scores for a first set of biomarkers associated with a first therapy in the plurality of therapies,
a second set of normalized biomarker scores for a second set of biomarkers associated with a second therapy in the plurality of therapies, and
a third set of normalized biomarker scores for a third set of biomarkers associated with a third therapy in the plurality of therapies,
wherein the first set of biomarkers is different from the second set of biomarkers, and wherein determining the first set of normalized biomarker scores comprises determining a first normalized biomarker score for the first biomarker using the distribution of values for the first biomarker at least in part by:
determining an un-normalized score for the first biomarker using the sequencing data,
determining a Z-score based on the first distribution of values for the first biomarker, and
determining a normalized score for the first biomarker based on the un-normalized score and the Z-score; and
determining, using the first, second, and third sets of normalized biomarker scores and a statistical model, respective first, second, and third therapy scores for the first, second and third therapies;
wherein the plurality of therapies comprise at least three therapies selected from the group consisting of: an anti-PD1 therapy, an anti-CTLA4 therapy, an IL-2 therapy, an IFN alpha therapy, an anti-cancer vaccine therapy, an anti-angiogenic therapy, and an anti-CD20 therapy, and
wherein the first, second, and third sets of biomarkers associated with the first, second and third each comprises at least three biomarkers selected from the group of biomarkers associated with the respective therapy in Table 2.
US Pat. No. 10,336,706

CRYSTALLINE FORM OF ELTROMBOPAG FREE ACID

HETERO RESEARCH FOUNDATIO...

1. A process for the preparation of crystalline Eltrombopag Form H1 having 2? angle positions at about 6.3, 7.0, 9.0, 11.5, 12.7, 14.2, 20.5, 23.1, 25.5 and 28.6±0.2 degrees, which comprises:a) dissolving Eltrombopag in dimethyl formamide;
b) heating the solution to reflux at 50-100° C.;
c) cooling the solution to below 35° C. and adding an alcoholic solvent selected from methanol, ethanol, n-butanol, and isopropanol;
d) heating the solution to reflux at 50-100° C. and e) isolating the crystalline Eltrombopag Form H1.
US Pat. No. 10,335,427

TUMOR PREVENTION AND TREATMENT DRUG AND APPLICATIONS THEREOF

Jianping Cai, Beijing (C...

1. A method for at least one of the treatment and control of tumors, comprising the following steps of:Step 1, preparing a medicament by mixing a biologically acceptable excipient or a carrier with 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) to obtain a therapeutically effective dose of 8-oxo-dGTP; and
Step 2, administration, to a mammal, the medicament containing the therapeutically effective dose of 8-oxo-dGTP.
US Pat. No. 10,335,428

P-ETHOXY NUCLEIC ACIDS FOR LIPOSOMAL FORMULATION

BIO-PATH HOLDINGS, INC., ...

1. A method of treating a subject with a cancer, an autoimmune disease, or an infectious disease comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a population of oligonucleotides, phospholipids, and a pharmaceutically acceptable carrier, wherein oligonucleotides of the population are composed of nucleoside molecules linked together through phosphate backbone linkages, wherein at least one of the phosphate backbone linkages in each oligonucleotide is a p-ethoxy backbone linkage, wherein no more than 80% of the phosphate backbone linkages in each oligonucleotide are p-ethoxy backbone linkages, and wherein the oligonucleotides and phospholipids form an oligonucleotide-lipid complex.
US Pat. No. 10,339,274

VIRAL NEOEPITOPES AND USES THEREOF

NANTOMICS, LLC, Culver C...

1. A method of treating a patient having a virus-associated tumor, comprising:obtaining a biopsy sample from the virus-associated tumor of the patient and analyzing the biopsy sample to identify a non-patient nucleic acid in the virus-associated tumor;
determining a plurality of nucleic acid sequences encoding patient-specific and tumor-specific neoepitopes for the virus-associated tumor by identifying overlaps between the non-patient nucleic acid and a reference nucleic acid of a virus known to be related to the virus-associated tumor, wherein each of the neoepitopes has a length of between 5 and 30 amino acids, and wherein the non-patient nucleic acid includes a mutation compared to the reference nucleic acid of the virus related to the virus-associated tumor, and wherein the mutation occurs upon insertion of the non-patient nucleic acid into a patient's host genome;
identifying an HLA-matched neoepitope from the plurality of patient-specific and tumor-specific neoepitopes, wherein the HLA-matched neoepitope includes the non-patient nucleic acid, includes the mutation, and has a dissociation constant equal to or less than 100 nM with an HLA-type of the patient; and
administering to the patient having the virus-associated tumor an immunotherapeutic composition comprising a recombinant virus that includes the nucleic acid encoding the HLA-matched neoepitope or a recombinant cell expressing a recombinant protein that targets the HLA-matched neoepitope, thereby triggering an immune response against the HLA-matched neoepitope of the virus-associated tumor.
US Pat. No. 10,335,430

INULIN PRODUCTS WITH IMPROVED NUTRITIONAL PROPERTIES

TIENSE SUIKERRAFFINADERIJ...

1. A food or feed composition or supplement, comprising a human or animal food or feed, a mixture of an easily fermentable inulin (EFI) component and a hardly fermentable inulin (HFI) component, said food or feed composition or supplement consisting of the following combination of functional ingredients: a weight ratio of EFI and HFI ranging from about 40/60 to about 45/55, wherein the EFI component is free from agave inulin and consists of a short-chain inulin with a number average degree of polymerization (DP)<10, the HFI component consists of a long-chain chicory inulin with a number average degree of polymerization (DP)>20, and the total content of inulin in the combined EFI and HFI components with (DP)=9 and (DP)=10 is maximally 5 wt % based on total inulin, determined by gas liquid chromatography (GLC), and a bio-available mineral, said composition providing improved beneficial nutritional properties of inulin without causing adverse intestinal side effects.
US Pat. No. 10,340,050

METHOD OF DECONTAMINATING METAL SURFACES IN A COOLING SYSTEM OF A NUCLEAR REACTOR

FRAMATOME GMBH, Erlangen...

1. A method of decontaminating metal surfaces in a cooling system of a nuclear reactor, wherein the metal surfaces are coated with metal oxides including containing radioisotopes, and wherein the cooling system comprises one or more primary loops including at least one reactor coolant pump, and a residual heat removal system, the method comprises conducting a plurality of treatment cycles, with each of the treatment cycles comprising:a) an oxidation step wherein the metal oxides containing radioisotopes are contacted with an aqueous solution of a permanganate oxidant;
b) a decontamination step wherein the metal oxides subjected to the oxidation step are contacted with an aqueous solution of an organic acid selected from the group consisting of oxalic acid, formic acid, citric acid, tartaric acid, picolinic acid, gluconic acid, glyoxylic acid and mixtures thereof, so as to dissolve at least part of the metal oxides and the radioisotopes; and
c) a cleaning step wherein at least the radioisotopes are immobilized on an ion exchange resin;
wherein the oxidation step comprises at least one acidic oxidation step and at least one alkaline oxidation step carried out one after another in either the same or different treatment cycles, and wherein the plurality of treatment cycles comprises at least one treatment cycle including a high temperature oxidation step, during which high temperature oxidation step the permanganate oxidant solution is kept at a temperature of at least 100° C. and wherein the at least one reactor coolant pump is used to circulate and heat the oxidation solution inside the one or more primary loops and the residual heat removal system is used to control the temperature of the oxidant solution during the high temperature oxidation step.
US Pat. No. 10,335,440

DIRECT-FED MICROBIALS

Microbial Discovery Group...

1. A method of feeding an animal, the method comprising the step of administering to the animal a feed composition or drinking water comprising an effective amount of an additive comprising an isolated Bacillus strain selected from the group consisting of Bacillus strain 101 (NRRL No. B-67218), Bacillus strain 235 (NRRL No. B-67219), Bacillus strain 77 (NRRL No. B-67274), Bacillus strain 177 (NRRL No. B-67275), Bacillus strain 102 (NRRL No. B-67276), a strain having all of the identifying characteristics of Bacillus strain 101 (NRRL No. B-67218), a strain having all of the identifying characteristics of Bacillus strain 235 (NRRL No. B-67219), a strain having all of the identifying characteristics of Bacillus strain 77 (NRRL No. B-67274), a strain having all of the identifying characteristics of Bacillus strain 177 (NRRL No. B-67275), a strain having all of the identifying characteristics of Bacillus strain 102 (NRRL No. B-67276), and combinations thereof, wherein the Bacillus strain causes E. coli inhibition in the animal.
US Pat. No. 10,339,799

METHOD AND SYSTEM TO IDENTIFY CONGESTION ROOT CAUSE AND RECOMMEND POSSIBLE MITIGATION MEASURES BASED ON CELLULAR DATA AND RELATED APPLICATIONS THEREOF

CELLINT TRAFFIC SOLUTIONS...

5. A method for analyzing a root cause of congestion at a specific route section, the method comprising the actions of:collecting signaling data from a cellular network;
identifying people who travel at the specific route section during congestion;
tracking the people that were detected in the congestion and identifying the root cause of the congestion by analyzing Origin Destination (OD) data before and after they were detected on the specific route section; and
identifying origins, destinations or combinations thereof, that are contributing the larger amount of cars and/or travelers to the specific route section thereby causing the congestion.
US Pat. No. 10,340,055

EMULSIONS WITH IMPROVED STABILITY

ELANTAS PDG, INC., St. L...

1. A method of impregnating or coating an electrical or electromechanical device, wherein the method comprises adding a low VOC emulsion to the electromechanical device and curing the applied emulsion, the low VOC emulsion comprisinga1) an unsaturated polyester or a mixture of unsaturated polyesters,
a2) water,
b) at least one radical polymerisation initiator or a mixture of radical polymerisation initiator and promoter,
c) at least one surfactant having an HLB-value of greater than 15,
d) optionally, at least one reactive diluent, and
e) optionally, further additives.
US Pat. No. 10,335,444

METHOD FOR EXTRACTING HIGH CONTENT OF CHLOROGENIC ACIDS FROM GREEN COFFEE BEANS

Pawan Kumar Goel, Panchk...

1. A method to produce an enriched extract having chlorogenic acids content ranging between 70-80 weight %, from dried coffee beans, wherein the method comprises the steps of:i. powdering the dried coffee beans;
ii. extracting the powdered coffee beans by adding a water-alcohol mixture in quantity four times the dried coffee beans by volume and stirring at a temperature between 45-55° Celsius for 4 hours to form a mixture;
iii. filtering the mixture;
iv. repeating the extraction of steps ii) and iii) 2-3 times until the powdered coffee beans are completely exhausted and a hydro-alcoholic mixture is obtained;
v. concentrating the hydro-alcoholic mixture by vacuum to reduce the volume to one fourth and to obtain an aqueous layer;
vi. removing fats from the aqueous layer by washing with hexane;
vii. removing caffeine by washing with a chlorinated solvent;
viii. extracting chlorogenic acids with a polar solvent which has polarity less than that of alcohols; and
ix. evaporating the polar solvent to obtain a dry powder extract in which the content of chlorogenic acids ranges between 70-80 weight % wherein the step of removing caffeine by washing with a chlorinated solvent takes place after the powdered coffee beans are extracted by adding the water-alcohol mixture.
US Pat. No. 10,336,982

TARGETED MUTAGENESIS IN SPIRULINA

LUMEN BIOSCIENCE, INC., ...

1. A non-naturally occurring, stable transformant Arthrospira cell, comprising:a. an introduced targeted nucleotide mutation incorporated into the cell's genome,
wherein the introduced targeted nucleotide mutation is flanked on each side by a region of nucleotides that are homologous to nucleotide homology arms contained in a vector utilized to transform said cell and wherein the introduced targeted nucleotide mutation is stable for at least 50 generations.
US Pat. No. 10,335,449

RHO ASSOCIATED KINASE (ROCK) INHIBITORS AND THEIR USE IN TREATING DISEASE

University of Houston Sys...

1. A method of treating cardiovascular disease and/or conditions involving remodeling comprising administering to a subject in need thereof a pharmaceutical composition comprising (a) a peptide consisting of 4-30 residues and exhibiting the sequence ERTYSPS (SEQ ID NO: 69) and (b) a pharmaceutically acceptable buffer, excipient or diluent.
US Pat. No. 10,335,456

METHODS OF USING ZSCAN4 FOR REJUVENATING HUMAN CELLS

Elixirgen Therapeutics, I...

1. A method of treating bone marrow failure associated with Fanconi anemia, dyskeratosis congenita or Hoyeraal-Hreidarsson syndrome, comprising:i. contacting one or more human bone marrow or blood cells with an isolated nucleic acid molecule encoding Zscan4 or a Zscan4 protein, and wherein the isolated nucleic acid molecule encoding the Zscan4 or the Zscan4 protein induces extension of telomeres in the one or more human bone marrow or blood cells; and
ii. engrafting the contacted one or more human bone marrow or blood cells into the subject to treat the bone marrow failure associated with the Fanconi anemia, dyskeratosis congenita or Hoyeraal-Hreidarsson syndrome, wherein the bone marrow failure is caused by telomere shortening, and wherein the associated bone marrow failure is ameliorated.
US Pat. No. 10,335,461

INTERFERON THERAPY

Trizell Limited, Chinnor...

1. A method of treating a human patient with interferon comprising:a. diagnosing in a human patient a cancer which may be treated with interferon, and then
b. administering to the human patient interferon or an agent which induces interferon in a therapeutically effective amount, wherein interferon up-regulates programmed death protein ligand (PD-L1), and
c. administering to the human a monoclonal antibody against programmed cell death protein 1, the monoclonal antibody against programmed cell death protein 1 administered in an amount effective to ameliorate the decrease in T cell function which interferon would cause,whereby the monoclonal antibody against programmed cell death protein 1 ameliorates the decrease in T cell function caused by interferon.
US Pat. No. 10,335,977

METHOD FOR TREATING A WOOD BOARD

SURFACTOR GERMANY GMBH, ...

1. A method for treating a plywood or an oriented strand board for use as a mold form for molding concrete, the method comprising: (a) providing a hydrophobic composition containing a hydrophobic agent in an amount of 60 to 100% by weight on a surface of the plywood or the oriented strand board; (b) coating the plywood or the oriented strand board with a coating agent to form a coating layer on the surface of the plywood or the oriented strand board treated with the hydrophobic composition to form a treated plywood or oriented strand board, wherein the hydrophobic agent comprises alkene ketene dimer, and wherein the hydrophobic composition and the coating layer are provided on the plywood or the oriented strand board by hot pressing sufficient to cause the hydrophobic agent to penetrate into wood grains in the plywood or the oriented strand board, and wherein the amount of hydrophobic composition provided on the surface of the plywood or the oriented strand board is 30-50 g/m2, and wherein the coating agent forms a film and comprises one or more resins selected from phenolic resin, amino resin, acrylate resin, urea resin, melamine resin, or urea melamine resin; and (c) molding concrete using the treated plywood or oriented strand board.
US Pat. No. 10,335,466

AADC POLYNUCLEOTIDES FOR THE TREATMENT OF PARKINSON'S DISEASE

VOYAGER THERAPEUTICS, INC...

1. An adeno-associated virus (AAV) vector genome comprising, in order:a) a 5? inverted terminal repeat (ITR), wherein said 5? ITR is 141 nucleotides in length;
b) a cytomegalovirus (CMV) sequence region comprising from 5? to 3? a CMV enhancer or a fragment thereof of at least 250 nucleotides, and a CMV promoter or a fragment thereof of at least 150 nucleotides, wherein said CMV sequence region is at least 500 nucleotides;
c) an immediate early 1 (IE1) sequence region comprising IE1 exon1 or a fragment thereof of at least 50 nucleotides, and IE1 intron 1 or a fragment thereof of at least 20 nucleotides;
d) a human beta globin (HB) sequence region comprising HB intron 2 or a fragment thereof of at least 250 nucleotides, and HB exon 3 or a fragment thereof of at least 40 nucleotides;
e) an Aromatic L-amino acid decarboxylase (AADC) sequence region, said AADC sequence region comprising a nucleotide sequence encoding SEQ ID NO: 1;
f) a poly(A) signal sequence region comprising a human growth hormone (hGH) poly(A) signal or a fragment thereof of at least 200 nucleotides; and
g) a 3? ITR, wherein said 3? ITR is 141 nucleotides in length;wherein the AAV vector genome comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 17 and variants having at least 95% identity thereto.
US Pat. No. 10,335,467

METHODS OF TREATMENT USING ALPHA-1-ANTITRYPSIN COMPOSITIONS

CSL Behring L.L.C., King...

1. A method of treating alpha-1-antitrypsin (AAT) deficiency in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a pharmaceutical composition comprising plasma-derived alpha-1-antitrypsin (AAT), wherein said composition further comprises:(a) 2% or less contaminating proteins based on total protein weight and as determined by SDS-PAGE; and
(b) less than 0.5% antithrombin III based on total protein weight;
wherein the specific activity of the AAT is at least 0.99 mg functional AAT per milligram of protein when using as an extinction coefficient E1 cm, 280 nm1%=5.3;
wherein less than 8% of the composition is of a higher molecular weight than monomeric AAT as determined by size-exclusion high-performance liquid chromatography (HPLC);
wherein the total protein weight is measured using a Bradford assay or by absorbance at 280 nm using as an extinction coefficient E1 cm, 280 nm1%=5.3.
US Pat. No. 10,335,472

THERAPEUTIC CANCER VACCINE

Cadila Pharmaceuticals Lt...

1. A method for inducing an anticancer immune response in a mammalian subject having a cancer, said method comprising harvesting cancer cells cultured in vitro, washing the cells to remove traces of serum, culturing the cancer cells in vitro in the presence of Mycobacterium w. for a period of time sufficient to induce the expression by the cancer cells of p38, separating the cancer cells from the Mycobacterium w. cells by centrifugation, measuring the level of p38 expression in the cancer cells, collecting cancer cells overexpressing p38 as compared to cancer cells not contacted with Mycobacterium w., irradiating or killing the cancer cells, and administering to the subject an effective amount of the irradiated or killed cancer cells overexpressing p38 to induce an anticancer immune response.
US Pat. No. 10,335,473

PEPTIDE MIXTURE

TARGOVAX ASA, Oslo (NO)

1. A peptide mixture suitable for eliciting an immune response comprising a first, a second a third, a fourth, a fifth, a sixth, a seventh and an eighth, peptide, each corresponding to a fragment of the RAS protein wherein:the first, second, third, fourth, fifth, sixth, seventh and eighth peptides are:
a peptide comprising the amino acid sequence of SEQ ID NO: 19,
a peptide comprising the amino acid sequence of SEQ ID NO: 20,
a peptide comprising the amino acid sequence of SEQ ID NO: 21,
a peptide comprising the amino acid sequence of SEQ ID NO: 22,
a peptide comprising the amino acid sequence of SEQ ID NO: 23,
a peptide comprising the amino acid sequence of SEQ ID NO: 24,
a peptide comprising the amino acid sequence of SEQ ID NO: 25, and
a peptide comprising the amino acid sequence of SEQ ID NO: 26;and whereineach peptide comprises no more than 30 amino acids.
US Pat. No. 10,337,012

METHOD AND COMPOSITION FOR THE TREATMENT, PREVENTION, AND DIAGNOSIS OF CANCER CONTAINING OR DERIVED FROM CANCER STEM CELLS

3-D Matrix, Ltd., Tokyo ...

1. A method of treating a cancer containing or derived from cancer stem cells comprising a step of administering an siRNA-carrier complex comprising an siRNA against ribophorin II (RPN2) and a transport carrier to a subject in need thereof, wherein the cancer stem cells have a mutated p53 gene, and wherein the siRNA interferes with RPN2 gene expression in an in vitro assay.
US Pat. No. 10,337,015

MODULATION OF PRE-MRNA USING SPLICE MODULATING OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS IN THE TREATMENT OF DISEASE

Drexel University, Phila...

1. A composition comprising: a splice modulating oligonucleotide (SMO) sequence that specifically binds a complementary sequence of a pre-mRNA that undergoes splicing to form a mRNA encoding a glutamate activated ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit (GluR), wherein said SMO decreases expression of the flip isoform of said GluR in a cell, wherein said SMO comprises SEQ ID NO: 143 and is selected from SEQ ID Nos 65, 66, 68, 69, 83, 84, 85, 102, 103, 104 and 122, and wherein at least one nucleotide in said SMO contains a non-naturally occurring modification.
US Pat. No. 10,337,017

METHOD OF STIMULATING TLR9-ACTIVATED IMMUNE RESPONSE

National Health Research ...

1. A method of stimulating a TLR9-activated immune response or enhancing a TLR9-activated immune response to an antigen, comprising administering to a rabbit or a mouse an effective amount of an immunogenic composition comprising an antigen and a CpG-oligodeoxynucleotide (CpG-ODN) comprising a GACGTT motif or a AACGTT motif; wherein said CpG-ODN consists of the sequence of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 5, or SEQ ID NO: 6.
US Pat. No. 10,337,019

FUNGAL ARTIFICIAL CHROMOSOMES, COMPOSITIONS, METHODS AND USES THEREFOR

INTACT GENOMICS, INC., S...

1. A fungal artificial chromosome (FAC) comprising a bacterial artificial chromosome (BAC) vector comprising:a low-copy number bacterial origin of replication;
an inducible high-copy number bacterial origin of replication;
an E. coli selectable marker gene;
an Aspergillus selectable marker gene; and
an AMA1 filamentous fungal autonomous replicating element,wherein the FAC is a plasmid that replicates extrachromosomally in an E. coli host and in an Aspergillus fungal host.
US Pat. No. 10,337,020

NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM

22nd Century Limited LLC,...

1. A method for reducing a nicotinic alkaloid in a Nicotiana plant, comprising down-regulating a transcription factor that positively regulates nicotinic alkaloid biosynthesis, wherein the transcription factor is down-regulated by:(a) introducing into a Nicotiana plant cell a nucleic acid comprising at least 21 consecutive nucleotides of a cDNA molecule comprising a nucleotide sequence selected from the group consisting of:
(i) a nucleotide sequence set forth in SEQ ID NO: 11 or SEQ ID NO: 12;
(ii) a nucleotide sequence that encodes a polypeptide having the amino acid sequence set forth in SEQ ID NO: 13;
(iii) a nucleotide sequence that is at least 90% identical to the nucleotide sequences of (i) or (ii), and which encodes a transcription factor that positively regulates nicotinic alkaloid biosynthesis; and
(iv) a nucleotide sequence that hybridizes under high stringency conditions to the nucleotide sequences of (i), (ii), and/or (iii), and which encodes a transcription factor that regulates nicotinic alkaloid biosynthesis, wherein the high stringency conditions comprise hybridization at 68° C., washing with 2×SSE and 0.05% SDS five times at 68° C., and washing with 0.1×SSC and 0.1% SDS at 68° C. for 1 hour;
wherein the consecutive nucleotides are in sense orientation, antisense orientation, or both;
(b) producing a Nicotiana plant comprising the Nicotiana plant cell; and
(c) growing the Nicotiana plant under conditions whereby the nucleotide sequence decreases levels of the transcription factor in the Nicotiana plant as compared to a control Nicotiana plant grown under similar conditions.
US Pat. No. 10,335,492

INCREASING SERUM HALF-LIFE OF HUMAN IL-11 VARIANTS BY N-TERMINAL BRANCHED PEGYLATION

NANSHA BIOLOGICS (HONG KO...

1. A method of increasing serum half-life of an interleukin 11 (IL-11) compound, comprising:providing an IL-11 conjugate preparation by covalently coupling an IL-11 polypeptide chain to a PEG moiety by a process that selectively couples the PEG moiety to the N-terminus of the IL-11, wherein the PEG moiety has an average molecular weight of between 10-50 Kd and has at least two branches, and wherein an equimolar to 2-fold molar excess of the PEG moiety relative to the IL-11 is present during coupling;
wherein the IL-11 conjugate preparation comprises a monosubstituted IL-11 conjugate at a purity of greater than 93%; and
wherein the IL-11 polypeptide chain is a human IL-11 or truncated human IL-11 polypeptide chain.
US Pat. No. 10,337,033

CARBONYL REDUCTASE OLIGOMERS AND THEIR APPLICATION IN SYNTHESIS OF CHIRAL ALCOHOLS

Jiangnan University, Wux...

1. A carbonyl reductase oligomer, wherein said carbonyl reductase oligomer comprises two of the same carbonyl reductase polypeptide, wherein the C-terminus of a first carbonyl reductase polypeptide is connected to the N-terminus of a second carbonyl reductase polypeptide by a sortase A (Srt A) recognition sequence via a Srt A mediated ligation mechanism, wherein said carbonyl reductase is selected from a group consisting of SCRII of SEQ ID NO: 1, SCR1 of SEQ ID NO:18, SCR3 of SEQ ID NO:19, CR2 of SEQ ID NO:20, and CR4 of SEQ ID NO:21; and wherein said carbonyl reductase oligomer has higher specific activity than that of the wild-type counterpart enzyme.
US Pat. No. 10,335,498

RNA BASED BIOMATERIAL FOR TISSUE ENGINEERING APPLICATIONS

University of Iowa Resear...

1. A composition comprising chemically modified RNA (cmRNA) encapsulated in or complexed with a non-viral delivery vehicle comprising polyamidoamine (PAMAM) dendrimers or polyethylenimine (PEI) and a biocompatible, bioresorbable scaffold comprising collagen, wherein at least 90% of the cytosine (C) and uridine (U) in the cmRNA are substituted with 5-methylcytidine-5 triphosphate, pseudouridine-5-triphosfate, or a combination thereof, and wherein the composition comprises sequences that encode at least two proteins selected from the group consisting of a BMP, osteocalcin, type I collagen, core binding factor, PDGF, TGF-beta, antibody to sclerostin or the antigen binding fragment thereof, antibody to receptor activator of nuclear factor kappa-B ligand (RANKL) or the antigen binding fragment thereof, osterix, HGF, bFGF, NGF, neuregulin, or activin.
US Pat. No. 10,338,061

METHOD FOR DIAGNOSIS OF DISEASES USING MORPHOLOGICAL CHARACTERISTICS OF LUTERIAL

Young Ah Kwon, Seoul (KR...

1. A method of treating a cancer patient, said method comprising:(a) imaging luterial from a sample of a body fluid of the patient, by microscopy, to present luterial shape(s), wherein the patient has a cancer selected from the group consisting of lung cancer, breast cancer, pancreatic cancer, common bile duct cancer, pleural mesothelioma thyroid cancer, ovarian cancer, biliary track cancer, prostate cancer, acute lymphoblastic leukemia, liver cancer, angiosarcoma of liver, colorectal cancer, uterine cancer, gastric cancer, rectal cancer, acute myeloid leukemia, rectal cancer, and non-small cell lung cancer;
(b) based on the luterial shape(s) in the luterial imaged by microscopy from the sample of the body fluid of the patient, diagnosing a progressionary stage of said cancer; and
(c) administering to the cancer patient a cancer treatment based on the progressionary stage of said cancer that is diagnosed in step (b).
US Pat. No. 10,335,501

CYCLIC PEPTIDES WITH ENHANCED NERVE-BINDING SELECTIVELY, NANOPARTICLES BOUND WITH SAID CYCLIC PEPTIDES, AND USE OF SAME FOR REAL-TIME IN VIVO NERVE TISSUE IMAGING

Memorial Sloan Kettering ...

1. A cyclic nerve-binding peptide conjugate comprising:from one to twenty cyclic nerve-binding peptide ligands, each having from 5 to 20 amino acid residues and/or a 15 atom to 60 atom macrocycle, wherein the one to twenty cyclic nerve-binding peptide ligands comprise the peptide sequence NTQTLAKAPEHT (SEQ ID NO: 1);
a silica-based nanoparticle, wherein the silica-based nanoparticle has a diameter less than 10 nm;
a fluorescent agent; and
a linker moiety attached to the silica-based nanoparticle, thereby coating the nanoparticle, wherein the one to twenty cyclic nerve-binding peptide ligands are attached to the coated silica-based nanoparticle.
US Pat. No. 10,338,065

DETECTION OF AMNIOTIC FLUID IN VAGINAL SECRETIONS OF PREGNANT WOMEN DUE TO PREMATURE RUPTURE OF FETAL MEMBRANES

Clinical Innovations, LLC...

1. A method for the detection of biomarkers in vaginal secretions of pregnant women indicative of premature rupture of fetal membranes, the method comprising:a) obtaining a fluid sample by placing a sterile swab in a vaginal vault of a pregnant woman;
b) removing the swab from the vaginal vault after a period of time from about fifteen seconds to about three minutes, and placing the swab in a vial containing a buffer solution;
c) allowing time for the fluids from the swab to be released into the buffer solution;
d) adding a few drops of the buffer solution that has been exposed to the fluids from the swab to a chromatographic specific binding assay strip device, the device created by including the following components:
i) a non-permeable platform strip;
ii) a permeable membrane testing strip positioned on top of the non-permeable platform strip, the permeable membrane testing strip further comprising a test site for the detection of the premature rupture of fetal membranes, the site comprising a blend, the blend comprising at least:
1) a first set of polyclonal antibodies for the detection of a first biomarker, the first biomarker indicating the premature rupture of fetal membranes, the first biomarker being alpha-fetoprotein;
2) a second set of polyclonal antibodies for the detection of a second biomarker, the second biomarker being indicative of the premature rupture of fetal membranes, the second biomarker being placental protein 12;
3) a first set of monoclonal antibodies for the detection of the first biomarker being indicative of the premature rupture of fetal membranes, the first set of monoclonal antibodies being specific for alpha-fetoprotein; and
4) a second set of monoclonal antibodies for the detection of a second biomarker, the second biomarker being indicative of the premature rupture of fetal membrane the second set of monoclonal antibodies being specific for placental protein 12;
wherein the ratio of polyclonal antibodies blended together are about 75% placental protein 12 to about 25% alpha-fetoprotein antibodies;
iii) a sample receiving pad positioned on top of and at a proximal end of the non-permeable platform strip while in contact with a proximal end of the permeable membrane testing strip;
iv) a reservoir pad positioned on top of and at a distal end of the non-permeable membrane testing strip while in contact with a distal end of the permeable membrane test strip; and
v) a conjugate pad positioned on top of or below the sample receiving pad, the conjugate pad comprising a permeable membrane containing a conjugate, the conjugate comprising a colorant attached to antibodies that can attach to analytes in the sample, wherein the conjugate of the sample binds to the analytes forming conjugate tagged analytes;
e) allowing time for the conjugate tagged analytes to migrate along the length of the permeable membrane strip to the test site; and
f) detecting binding between the biomarkers and their respective the monoclonal antibodies and the polyclonal antibodies by the presence of an indicator line at the test site.
US Pat. No. 10,335,761

METHOD OF MANUFACTURING BIO-DIESEL AND REACTOR

Louisiana Eco Green, L.L....

1. A method of forming bio-diesel comprising:emulsifying a mixture comprising water, alcohol and a source of fatty acids, wherein said alcohol comprises between about 7 and about 16 percent, by weight, of the mixture;
pressurizing and heating said emulsion until said alcohol is super-critical;
pumping said emulsion through a vessel under substantially non-laminar flow;
maintaining said substantially non-laminar flow of said emulsion and said super-criticality of said alcohol in said emulsion for at least about 1.5 minutes.
US Pat. No. 10,337,042

METHOD FOR PRODUCING GALACTOOLIGOSACCHARIDES FROM LACTOSE

Vitalus Nutrition Inc., ...

1. A galactooligosaccharide (GOS) composition comprising:galactose;
glucose;
?-D-Galp-(1?3)-D-Galp;
?-D-Galp-(1?6)-D-Galp;
?-D-Galp-(1?3)-D-Glcp;
?-D-Galp-(1?4)-D-Glcp;
?-D-Galp-(1?6)-?-D-Galp-(1?4)-D-Glcp;
?-D-Galp-(1?2)-D-Glcp;
?-D-Galp-(1?3)-DGlcp;
?-D-Galp-(1?4)-?-D-Galp-(1?4)-D-Glcp;
?-D-Galp-(1?3)-?-D-Galp-(1?4)-D-Glcp;
?-D-Galp-(1?6)-?-D-Galp-(1?6)-?-D-Galp-(1?4)-D-Glcp;
?-D-Galp-(1?6)-?-D-Galp-(1?3)-?-D-Galp-(1?4)-D-Glcp; and
?-D-Galp-(1?6)-?-D-Galp-(1?4)-?-D-Galp-(1?4)-D-Glcp.
US Pat. No. 10,335,763

MICROPOROUS CARBON MONOLITHS FROM NATURAL CARBOHYDRATES

Entegris, Inc., Billeric...

1. A carbon pyrolyzate characterized by:derivation from naturally-occurring carbohydrate source material;
<1% total ash content, as determined by the procedure of ASTM D2866-11;
piece density in a range of from 0.50 g/cc to 1.40 g/cc;
N2 BET surface area greater than 750 m2/gm;
having from 40% to 90% of its pore volume in micropores having a size in a range of 0.3 nm to less than 2.0 nm; and
methane adsorption capacity, at 21° C. and 35 bar pressure, of greater than 100V/V.
US Pat. No. 10,335,509

PRESSURE-SENSITIVE ADHESIVE AGENT FOR SKIN, PRESSURE-SENSITIVE ADHESIVE SHEET FOR SKIN, AND FACE PLATE OF OSTOMY APPLIANCE

ALCARE CO., LTD., Tokyo ...

1. A pressure-sensitive adhesive agent for skin, consisting of:5 to 20% by weight of a hydrogenated styrene-butadiene rubber,
35 to 55% by weight of at least one hydrophilic polymer compound selected from the group consisting of sodium carboxymethyl cellulose, pectin, karaya gum, and gelatin,
a softener component comprising a single softener of 25 to 30% by weight, wherein said single softener is selected from the group consisting of polyisobutylene, polyisoprene, polybutadiene, polybutene, styrene-isoprene rubber, ethylene-propylene rubber, styrene-ethylene-propylene rubber, and derivatives thereof,
0.05 to 3% by weight of a ceramide,
2 to 20% by weight of a mineral oil,
1 to 25% by weight of a tackifying resin comprising a petroleum resin,
and optionally one or more components selected from the group consisting of:
one or more thermoplastic elastomers, one or more hydrophilic polymers,
one or more physiologically active agents selected from the group consisting of sphingolipid, urea, glycolic acid, amino acids and derivatives thereof, protein hydrolysates, mucopolysaccharides and derivatives thereof, a vitamin B group, ascorbic acids, retinoids, vitamin D, vitamin E and derivatives thereof, carotenoids, enzymes, coenzymes, and ?-oryzanol,
one or more oils selected from the group consisting of vegetable oils, animal oils, and synthetic oils,
one or more adhesiveness-imparting resins selected from the group consisting of aliphatic copolymers, aromatic copolymers, aliphatic-aromatic copolymers, alicyclic copolymers, coumarone-indene resins, terpene resins, terpene-phenol resins, rosin resins; (alkyl) phenol resins, xylene resins, and hydrogenated resins thereof, and one or more ingredients selected from the group consisting of powder and pH adjusters.
US Pat. No. 10,338,072

METHOD OF DETECTING CANCER

Sienna Cancer Diagnostics...

1. A method for detecting bladder cancer epithelial cells comprising:performing a cytological assessment of cells in a fluid sample comprising bladder epithelial cells, wherein said performing detects bladder epithelial cells having atypical cell morphology that is indeterminate of malignancy, wherein the sample is from a subject suspected of having bladder cancer;
contacting the sample with an anti-telomerase antibody; and
detecting binding of the anti-telomerase antibody to the bladder epithelial cells having atypical cell morphology that is indeterminate of malignancy.
US Pat. No. 10,336,793

FLAGELLIN-BASED AGENTS AND USES INCLUDING EFFECTIVE VACCINATION

GENOME PROTECTION, INC., ...

1. A method of vaccinating a subject against a disorder, comprising administering an effective amount of a vaccine comprising:(a) an adjuvant comprising:
a flagellin-based agent comprising an amino acid sequence having at least 95% identity with SEQ ID NO: 2, and
an aluminum gel or salt,
wherein the ratio (w/w) of flagellin-based agent to aluminum gel or salt is about 1:500 or less and
(b) an antigen which stimulates protective immunity against the disorder,
wherein the antigen is a constituent of an infectious agent selected from a live and attenuated, killed, inactivated, and toxoid infectious agent;
and wherein the disorder is selected from infectious diseases, cancers, and allergies.
US Pat. No. 10,335,515

HYDROGEL PRECURSORS HAVING NANOPARTICLES

The University of Kansas,...

1. A shape retaining implantable hydrogel precursor composition comprising:a cross-linkable hyaluronic acid polymer having a cross-linkable functional group forming a cross-linkable polymer matrix that is biocompatible;
a photoinitiator; and
a plurality of polymer nanoparticles in the cross-linkable polymer matrix, wherein the polymer nanoparticles are cross-linked hyaluronic acid,
wherein:
the cross-linkable hyaluronic acid polymer is present from about 2% to about 10%;
the polymer nanoparticles are present from about 10% to about 40%; and
the cross-linkable hyaluronic acid polymer matrix having the polymer nanoparticles is a non-flowable gel or paste and has a yield stress in Pa at zero shear rate s?1, wherein:
the cross-linkable functional group is cross-linkable with the photoinitiator, and
the shape retaining implantable hydrogel precursor composition has a shape and shape retention thereof.
US Pat. No. 10,336,796

TREATMENT OF ISCHEMIA

MOREHOUSE SCHOOL OF MEDIC...

1. A method of manufacturing a medicament for treatment of ischemia, comprising:combining an effective amount of an acid sensing ion channel 1a (ASIC1a) inhibitor with a vehicle to produce a medicament for administration to an ischemic subject for treatment of ischemia.
US Pat. No. 10,337,053

LABELING HYDROXYMETHYLATED RESIDUES

THE UNTTED STATES OF AMER...

1. A method comprising:(a) labeling covalently, a hydroxyl group on a hydroxymethylated residue in a mammalian nucleic acid to generate a labeled 5-hydroxymethylcytosine residue, wherein said labeling comprises glycosylating the hydroxyl group by employing an alpha-glucosyltransferase, a beta-glucosyltransferase, or a beta-glucosyl-alpha-glucosyl-transferase; and
(b) sequencing said mammalian nucleic acid comprising said labeled hydroxymethylated residue.
US Pat. No. 10,335,517

POROUS POLYMER MATERIAL, PREPARATION METHOD THEREFOR, AND BIOMATERIAL USING SAME

Dankook University Cheona...

1. A porous polymer material having a porous structure over a surface and an inside of the polymer material,wherein the porous structure includes a plurality of first pores formed over the surface of the polymer material, a plurality of second pores in the form of column pores and formed up to a certain distance from the surface of the polymer material, and a plurality of third pores connected to each other and disposed under the plurality of second pores,
wherein the porous polymer material may be in the form of particles, and an average particle size of the particles is 10 to 3000 ?m.
US Pat. No. 10,338,081

TYPE 2 DIABETES BIOMARKERS AND USES THEREOF

Caprion Biosciences Inc.,...

1. A method for monitoring the effectiveness of a diabetic treatment in a subject having type 2 diabetes, the method comprisingdetermining the level of carboxypeptidase M (CPM), insulin-1 (INS), matrilysin (MMP7), and low-density lipoprotein receptor (LDLR) in a first fluid sample(s) obtained from the subject prior to the initiation of the treatment,
wherein the determining of the level of CPM, INS, MMP7, and LDLR in the first fluid sample(s) is performed using mass spectrometry or immunoassay;
determining the level of CPM, INS, MMP7, and LDLR in a second fluid sample(s) obtained from the subject after the treatment has been administered,
wherein the determining of the level of CPM, INS, MMP7, and LDLR in the second fluid sample(s) is performed using mass spectrometry or immunoassay; and
comparing the level of CPM, INS, MMP7, and LDLR in the first sample(s) with a level of CPM, INS, MMP7, and LDLR in the second sample(s), wherein a lower level of CPM, INS, and MMP7, and a higher level of LDLR in the second sample(s) as compared to the level of CPM, INS, MMP7, and LDLR in the first sample(s) indicates that the subject is responding to the diabetic treatment, thereby monitoring the effectiveness of the treatment in the subject.
US Pat. No. 10,336,033

RELEASE FILMS

Airtech International, In...

1. A release film comprising:a first outer layer having a first adhesion affinity and comprising a first base polymer comprising an ethylene tetrafluoroethylene (ETFE); and
a second outer layer having a second adhesion affinity that is different from the first adhesion affinity of the first outer layer, the second outer layer comprising:
a second base polymer comprising an ethylene tetrafluoroethylene (ETFE), and
an adhesion adjusting additive comprising a polyvinylidene fluoride (PVDF) or an ethylene tetrafluoroethylene (ETFE) additive that is different from the second base polymer.
US Pat. No. 10,338,082

METHODS FOR IN VITRO INVESTIGATING MITOCHONDRIAL REPLICATION DYSFUNCTION IN A BIOLOGICAL SAMPLE, KITS AND USES THEREOF, THERAPEUTIC METHODS AGAINST PROGEROID-LIKE SYNDROMES OR SYMPTOMES AND SCREENING METHOD FOR IDENTIFYING PARTICULAR PROTEASE INHIBITOR(S)

INSTITUT PASTEUR, Paris ...

1. An in vitro method to detect a protein in a sample from a subject suspected of having Cockayne syndrome (CS), comprising:a) providing at least one sample from a subject suspected of having CS; and
b) detecting in said sample at least one protein selected from the group consisting of: POLG1, POLG2, HTRA3, and HTRA2.
US Pat. No. 10,336,804

CHIMERIC NK RECEPTOR AND METHODS FOR TREATING CANCER

TRUSTEES OF DARTMOUTH COL...

1. A nucleic acid construct comprising: a first nucleic acid sequence encoding a promoter operably linked to a second nucleic acid sequence encoding a chimeric receptor polypeptide, said second nucleic acid sequence comprising a nucleic acid encoding a C-type lectin-like type II natural killer cell receptor polypeptide fused to a nucleic acid encoding an immune signaling receptor polypeptide comprising SEQ ID NO:1, wherein when the nucleic acid construct is introduced into a T-lymphocyte, said chimeric receptor polypeptide is expressed on the surface of the T-lymphocyte, and said C-type lectin type II natural killer receptor polypeptide binds a ligand and activates said immune signaling receptor polypeptide comprising SEQ ID NO: 1.
US Pat. No. 10,336,038

FIRE RESISTANT COATINGS FOR WOOD VENEER PANELS

Chase Corporation, Westw...

1. A method for treating panels comprising:coating a wood substrate with a polymeric solution comprising urethane acrylate; and
curing the coated wood substrate by subjecting the coated wood to a source of ultraviolet radiation and causing the polymeric solution to crosslink to produce a fire-resistant veneer, the ultraviolet radiation comprising a UV C dose between about 0.15 and about 0.6 J/cm2, a UV V dose between about 0.75 and about 3.5 J/cm2, a UV C irradiance between about 0.15 and about 0.24 W/cm2 and a UV V irradiance between about 0.7 and about 1.3 W/cm2.
US Pat. No. 10,336,810

CHIMERIC ANTIGEN RECEPTORS, ENCODING NUCLEIC ACIDS AND METHODS OF USE THEREOF

University Health Network...

1. A chimeric antigen receptor (CAR) comprising i) an extracellular domain capable of binding to a predetermined antigen, ii) a transmembrane domain and iii) an intracellular segment comprising a) one or more intracellular signaling domains selected from a cytoplasmic domain of an interleukin receptor chain and a cytoplasmic co-stimulatory domain and b) a CD3? intracellular signaling domain comprising an exogenous Signal Transducer and Activator of Transcription (STAT) 3 association motif, wherein the intracellular segment comprises an endogenous or exogenous JAK-binding motif and a STAT5 association motif.
US Pat. No. 10,336,811

MEMBRANE SPAN-KINASE FUSION PROTEIN AND THE USES THEREOF

VIB VZW, Ghent (BE) Univ...

1. A recombinant protein complex comprising:a first fusion protein consisting of a membrane spanning domain fused to a tyrosine kinase domain, wherein the tyrosine kinase domain has at least 95% sequence identity to amino acids 589-1187 of SEQ ID NO: 1, and
a second fusion protein consisting of an interaction domain fused to a reporter phosphorylation domain, wherein the phosphorylation domain has the amino acid sequence of SEQ ID NO: 2, and
wherein the tyrosine kinase domain can phosphorylate the tyrosine of the reporter phosphorylation domain upon the formation of a recombinant protein complex via an interaction between the membrane spanning domain and the interaction domain.
US Pat. No. 10,337,069

METHOD FOR DIAGNOSING HEPATIC FIBROSIS

VAIOMER, Labege (FR)

1. A method for diagnosing and treating a subject suffering from obesity for a treatment regimen targeting liver fibrosis and/or complications from liver fibrosis, said method comprisinga1) measuring the concentration of bacterial 16S rDNA, or the ratio of the quantity of bacterial 16S rDNA to the quantity of total DNA in a biological sample of a subject;
b) diagnosing liver fibrosis in the subject suffering from obesity based on the result of the measurement in a1); and
c) administering a drug treatment targeting liver fibrosis and/or complications from liver fibrosis to the subject.
US Pat. No. 10,336,814

METHOD FOR OBTAINING THIN FIBRIL COLLAGEN BY CONTACTING NATIVE COLLAGEN WITH AN ANTIBODY

MATRIX ODYSSEY, LLC, Nor...

1. A fibril collagen:wherein the fibril collagen is obtained by providing isolated collagen fibers, wherein the collagen fibers comprise native type II collagen fibers; and
treating the collagen fibers with an antibody to obtain the thin collagen fibrils, wherein the antibody comprises an anti-biglycan antibody and the thin collagen fibrils have a diameter of about 11.5 to about 12.5 nanometers.
US Pat. No. 10,340,150

NI:NIGE:GE SELECTIVE ETCH FORMULATIONS AND METHOD OF USING SAME

Entegris, Inc., Billeric...

1. A composition comprising about 0.01 wt % to about 10 wt % of at least one non-oxidizing acid, about 0.01 wt % to about 10 wt % of at least one unreacted metal dissolution agent, about 0.01 wt % to about 5 wt % of at least one germanium passivation agent, about 0.01 wt % to about 5 wt % of at least one metal germanide passivation agent, and about 70 wt % to about 99.96 wt % of at least one solvent,wherein the at least one non-oxidizing acid comprises a species selected from the group consisting of methanesulfonic acid, oxalic acid, citric acid, tartaric acid, picolinic acid, succinic acid, lactic acid, sulfosuccinic acid, benzoic acid, propionic acid, formic acid, oxalic acid, maleic acid, malonic acid, fumaric acid, malic acid, ascorbic acid, mandelic acid, heptanoic acid, butyric acid, valeric acid, glutaric acid, phthalic acid, hypophosphorous acid, 5-sulfosalicylic acid, hydrochloric acid, and combinations thereof, preferably oxalic acid, 5 sulfosalicylic acid, or combinations thereof;
wherein the unreacted metal dissolution agent comprises a species selected from the group consisting of ammonium sulfite monohydrate, ammonium sulfate, ammonium hypophosphite, tetrabutyl ammonium cyanate, sodium sulfite, potassium sulfite, sodium erythorbate, tocopherol, naringenin, glutathione, and combinations thereof;
wherein the germanium passivation agent comprises a species selected from the group consisting of boric acid, ammonium biborate, ammonium pentaborate, sodium tetraborate, 3-hydroxy-2-naphthoic acid, malonic acid, alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, decyltrimethylammonium chloride, carnitine, betaine, and combinations thereof;
wherein the metal germanide passivation agent comprises a species selected from the group consisting of 2-isopropylmalic acid, 2-propylmalic acid, 3-(4-hydroxyphenyl)lactic acid, 3-propylmalic acid, 4 hydroxymandelic acid, 2-hydroxyoctanoic acid, mandelic acid, squaric acid, 2-oxo-carboxylic acids, 5-sulfosalicylic acid, ethyl thioglycolate, 1,2-ethanedithiol, cysteine, methionine, dibenzothiophene, S-adenosylmethionine, taurine, glutathione, thiolactic acid, thiosalicylic acid, 2,2?-thiodiacetic acid, 3,3?-thiodipropionic acid, thioglycolic acid, dithiodiglycolic acid, 2,2?-(ethylenedithio)diacetic acid, 3-methoxybutyl thioglycolate, methyl thioglycolate, and combinations thereof and wherein the composition selectively removes unreacted metal relative to metal germanide, metal-III-V materials and germanium from the microelectronic device having the same thereon; and
wherein the solvent comprises a species selected from the group consisting of water, methanol, ethanol, isopropanol, butanol, pentanol, hexanol, 2-ethyl-1-hexanol, heptanol, octanol, and higher alcohols, 4-methyl-2-pentanol, ethylene glycol, propylene glycol, butylene glycol, butylene carbonate, ethylene carbonate, propylene carbonate, dipropylene glycol, diethylene glycol monomethyl ether, triethylene glycol monomethyl ether, diethylene glycol monoethyl ether, triethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, diethylene glycol monobutyl ether, triethylene glycol monobutyl ether, ethylene glycol monohexyl ether, diethylene glycol monohexyl ether, ethylene glycol phenyl ether, propylene glycol methyl ether, tripropylene glycol methyl ether (TPGME), dipropylene glycol dimethyl ether, dipropylene glycol ethyl ether, propylene glycol n-propyl ether, dipropylene glycol n-propyl ether (DPGPE), tripropylene glycol n-propyl ether, propylene glycol n-butyl ether, dipropylene glycol n-butyl ether, tripropylene glycol n-butyl ether, propylene glycol phenyl ether, and combinations thereof.
US Pat. No. 10,337,080

PROCESS FOR THE PRODUCTION OF GRAIN NON-ORIENTED ELECTRIC STEEL STRIP, WITH AN HIGH DEGREE OF COLD REDUCTION

CENTRO SVILUPPO MATERIALI...

1. A process for the production of a grain non-oriented electric steel strip, wherein the steel comprises by weight:Si 1.8%-6%
Al 0.2%-4%
Mn 0.2%-3%
S 0.0005%-0.01%
N 0.001%-0.01%
C 0.001%-0.01%
being Mn %/S %>100 and Al %/N %>200,
and, after casting and solidification in the form of a slab having a thickness Sp equal to or greater than 20 mm, is subjected to the following thermo-mechanical treatment:
optionally, heating of the slab at a temperature between 1000° C. and 1330° C.,
hot rolling of the slab to a temperature between 1300° C. and 700° C., with a total reduction rate between 70% and 99%, to obtain a hot rolled sheet (NAC) with thickness ranging between 2.5 mm and 12.0 mm,
cold rolling of the previously hot-rolled sheet, with a total reduction rate of not less than 80% according to the following sequence:
a) a first step of cold rolling (LAF) with a reduction rate between 20% and 70%, at a temperature below 300° C.;
b) an intermediate annealing softening at a temperature between 700° C. and 1100° C. for a time between 10 s and 900 s; and
c) a second step of cold rolling (LAF) with a reduction rate between 20% and 70%, wherein if said second step is repeated, it is preceded by an optional further intermediate annealing softening at a temperature between 700° C. and 1100° C. for a time between 10 [s] seconds and 900 [s] seconds,
final annealing for recrystallization and grains' growth, in continuous, of the cold-rolled sheet at a temperature between 800° C. and 1200° C. for a time of between 10 [s] seconds and 900 [s] seconds.