1. A method of treating sickle cell crisis, comprising administering a therapeutically effective amount of a pharmaceutical
composition comprising a SAE-CD of Formula 1:
wherein: n is 4, 5, or 6; R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each, independently, O or a O(C2-C6 alkylene)SO3? group, wherein at least one of R1 to R9 is independently a O(C2-C6 alkylene)SO3? group; and S1, S2, S3, S4, S5, S6, S7, S8 and S9 are each, independently, a pharmaceutically acceptable cation, to the composition, and clopidogrel, in combination with a
second therapeutic agent is selected from the group consisting of: folic acid, hydroxyurea, NSAIDs, antibiotics, iron chelators,
bronchodilators, diuretics, anxiolytics, ?-agonists, hydralazine, pentoxifylline, diltiazem, gonatropin-releasing hormone
analogs, diethylstilbestrol, and combinations of the foregoing.