US Pat. No. 9,283,016

SYSTEM AND METHOD FOR FORMING POROUS BONE FILLING MATERIAL

Warsaw Orthopedic, Inc., ...

1. A bone augmentation system comprising:
a first vessel at least partially filled with a gaseous substance;
a second vessel at least partially filled with a flowable and settable bone filling material;
a mixing vessel in fluid communication with both the first and second vessels to receive the gaseous substance and the flowable
and settable bone filling material, the mixing vessel including a mixing mechanism for mixing the gaseous substance and the
bone filling material to form a bone augmentation material, the mixing mechanism comprising a plurality of projections extending
from an inner surface of the mixing vessel configured to disperse the gaseous substance throughout the bone filling material;
and

a dispensing instrument comprising a dispensing reservoir for receiving the bone augmentation material and comprising a cannulated
member adapted to deliver the bone augmentation material into a body region adjacent cancellous bone.

US Pat. No. 9,333,276

BONE/POLYURETHANE COMPOSITES AND METHODS THEREOF

Vanderbilt University, N...

1. A biodegradable composite, comprising:
a plurality of bone particles;
a NCO-terminated prepolymer, the NCO-terminated prepolymer comprising a polyisocyanate that includes about 10 wt % to about
55 wt % NCO and a first polyol that includes a molecular weight of about 100 g/mol to about 1000 g/mol; and

a second polyol;
wherein the composite in a hardened state is biodegradable and has a porosity of at least 3%.

US Pat. No. 9,066,758

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. An extender comprising:
an outer member defining a longitudinal axis and including a body defining a lateral opening, the outer member further including
a first extension defining a first axial cavity and a second extension defining a second axial cavity, each of the axial cavities
including a first portion, a second portion and a third portion; and

an inner member including a body defining a tab configured for disposal in the lateral opening, the inner member further including
a first arm having a first projection disposed for movement within the first axial cavity and a second arm having a second
projection disposed for movement within the second axial cavity,

wherein the inner member is configured for axial translation relative to the outer member such that the projections are disposable
between a first position such that the projections are disposed with the first portions of the respective axial cavity and
the outer member is disposed in a non-expanded orientation, a second position such that projections are disposed with the
second portions of the respective axial cavity and the outer member is disposed in an expanded orientation, and a third position
such that the projections are disposed with the third portions of the respective axial cavity and the outer member is disposed
in an expanded orientation,

wherein the lateral opening includes a locking cavity comprising a plurality of lock slots such that the tab is movable into
the locking cavity to fix the inner member relative to the outer member in each of the positions.

US Pat. No. 9,486,478

COMPOSITIONS AND METHODS FOR PREFERENTIAL DISTRIBUTION OF ACTIVE AGENTS TO INJURY SITES

Warsaw Orthopedic, Inc., ...

1. A method of preferential distribution of one or more active agents to a site of injury comprising: identifying a patient
having an organ affected by a biological condition known to cause vessels supplying the organ to leak; and administering to
the patient a composition comprising a delivery ligand and one or more active agents at a dose of about 0.5 to about 10 ml
of composition per kg of patient's weight.

US Pat. No. 9,220,608

FACET JOINT IMPLANT DEVICE

Warsaw Orthopedic, Inc., ...

1. A bone graft implant device for treating a tissue site, the device comprising:
an implant body including a demineralized portion, the implant body having an outer surface comprising fully demineralized
portions and surface demineralized portions located at discrete positions on the outer surface of the implant, the discrete
positions being surface demineralized to a depth of about 50 microns to about 5000 microns, the implant body comprising a
modulus of elasticity in the range of about 1×105 to about 2×105 dynes/cm2; and

at least one engagement member protruding from the demineralized portion, the engagement member comprising only a mineralized
portion.

US Pat. No. 9,220,536

SYSTEM AND METHOD FOR CORRECTION OF A SPINAL DISORDER

Warsaw Orthopedic, Inc., ...

1. A method for fusionless correction of a spine disorder, the method comprising the steps of:
accessing a spine;
disposing a first end of a longitudinal element in a first aperture of a first fixation element and disposing a second end
of the longitudinal element in a second aperture of a second fixation element;

engaging a first planar surface of the first fixation element with a first costovertebral surface of a first vertebra, threading
the longitudinal element in the costotransverse orientation through a plurality of costovertebral spaces disposed along a
plurality of vertebral levels, and engaging a second planar surface of the second fixation element with a second costovertebral
surface of a second vertebra such that the first and second planar surfaces face one another and the longitudinal element
is disposed in a costotransverse orientation along a selected section of the spine; and

constraining growth of the selected section of the spine with the longitudinal element.

US Pat. No. 9,131,933

SURGICAL RETRACTOR AND METHOD OF USE

Warsaw Orthopedic, Inc., ...

1. A retractor comprising:
a base;
a first wall extending from the base, the first wall defining a longitudinal axis and extending between a first end and a
second end, the first wall further defining at least a portion of a longitudinal cavity and a second cavity disposed at the
first end;

a rotatable shaft including an outer surface defining a groove, at least a portion of the shaft being disposed with the longitudinal
cavity, the shaft including a head for disposal in the second cavity;

a blade being disposed for movement along the longitudinal cavity;
a post connected with the blade and disposed with the groove such that rotation of the shaft causes axial translation of the
blade relative to the first wall between a first orientation and a second orientation, the post extending perpendicular to
the longitudinal axis; and

a cap configured to snap into engagement with a cavity in the base, the cap including a bottom surface defining a first spine
surface, the head including a second spline surface that engages the first spline surface such that rotation of the shaft
is prevented upon fixation of the second spline surface with the base, the cap preventing the shaft from moving proximally
along the longitudinal axis.

US Pat. No. 9,090,029

PULTRUSION PROCESS FOR PREPARING COMPOSITES HAVING LOW PERCENTAGE OF FIBERS AND ARTICLES MADE FROM SAME

Warsaw Orthopedic, Inc., ...

1. A pultrusion process for-preparing a low percent of continuous reinforcing fibers composite material comprising the steps
of:
continuously pulling reinforcing fibers through an impregnation chamber comprising a mixture containing precursors and initiators
that polymerize when heated above a reaction temperature to produce impregnated continuous reinforcing fibers, wherein the
temperature of the impregnation chamber is below the polymerization temperature of the precursors and initiators in the impregnation
chamber;

wrapping the continuous reinforcing fibers with strands of curable matrix material having a lower melting point than a melting
point of the continuous reinforcing fibers, the continuous reinforcing fibers being selected from the group consisting of
metallic wire, carbon fibers, polyolefin fibers, polyester fibers, and aromatic polyamide fibers;

directing the wrapped continuous reinforcing fibers through a heated curing die to melt the matrix material about the wrapped
continuous reinforcing fibers and cure the matrix material so as to produce a solid fiber reinforced composite; and

withdrawing the solid fiber reinforced composite from the curing die, wherein the percentage of continuous fibers in the solid
fiber reinforced composite is between about 10 percent by volume and about 45 percent by volume.

US Pat. No. 9,078,808

DEVICE TO DELIVER MAGNESIUM IN PEG FORMULATION

Warsaw Orthopedic, Inc., ...

1. A container to supply a medicinal formulation to a patient in need thereof, the container comprising:
a medicinal formulation comprising:
polyethylene glycol (PEG) comprising PEG3350 in an amount ranging from 10% to 60% by weight (g) per 100 ml volume of the medicinal
formulation;

up to 80 mg of a magnesium chloride per kg of said patient's weight, and the magnesium chloride is present in an amount ranging
from 0.1 to 20% by weight (g) of magnesium per 100 ml volume of the medicinal formulation; and

an aqueous solution,
a first compartment storing either the PEG or the magnesium chloride of the medicinal formulation;
a second compartment disposed within the first compartment such that the second compartment is fluidly isolated from the first
compartment, the second compartment storing the other of the PEG or the magnesium chloride of the medicinal formulation;

at least one first frangible barrier shared between the first compartment and the second compartment, wherein the first and
second compartments each comprise an outer perimeter and the outer perimeter of the first compartment and the outer perimeter
of the second compartment intersect one another such that the second compartment is disposed at the outer perimeter of the
first compartment; and

a fluidic outlet for dispensing from the container the medicinal formulation, the fluidic outlet comprising at least one second
frangible barrier disposed therein,

wherein rupturing said at least one first frangible barrier causes the content of said first and second compartments to mix
producing said medicinal formulation such that said medicinal formulation is stable for up to 6 months before administration
to said patient.

US Pat. No. 9,050,138

VERTEBRAL ROD CONNECTOR AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. A vertebral rod connector comprising:
a first portion configured to engage a fastener construct and define a first longitudinal axis; the fastener construct configured
to secure the first portion to a vertebra

a second portion including continuous top and bottom surfaces extending between opposite side surfaces that are each continuous
with the top and bottom surfaces, the second portion comprising an uninterrupted inner surface that defines an enclosed opening
positioned between the top and bottom surfaces and configured for disposal of a vertebral rod, the opening extending along
a second longitudinal axis disposed transverse to the first longitudinal axis, wherein the opening is configured to receive
a vertebral rod such that the inner surface prevents the rod from moving along the first longitudinal axis in opposite first
and second directions while allowing the rod to be movable along the second longitudinal axis; and

a flexible linking portion disposed for connecting the first portion with the second portion, the linking portion having a
bifurcated configuration oriented transverse to the first longitudinal axis.

US Pat. No. 9,283,020

SURGICAL TACK DELIVERY SYSTEM, METHOD AND KIT

Warsaw Orthopedic, Inc., ...

1. A system for delivering a surgical tack in tissue, the system comprising:
a driver, comprising:
a shaft having a slot and a channel defining a longitudinal axis, said slot extending entirely through a distal end of said
shaft, said shaft comprising a shaft lip extending transverse to said longitudinal axis; and

a handle slidably connected to said shaft such that said shaft extends upward into said handle, said handle having a driving
mechanism and a handle lip extending transverse to said longitudinal axis, said driving mechanism having a driving pin for
providing a downward force through said shaft, a top surface of the handle lip is configured to directly contact a bottom
surface of the shaft lip;

a tack cartridge comprising a passageway defined by upper and lower surfaces of said tack cartridge, said upper and lower
surfaces including pass-through holes at one end of said tack cartridge, said passageway having a plurality of tacks disposed
therein, said tack cartridge being positioned in said slot such that the shaft is in alignment with said pass-through holes,
said tack cartridge being adapted to feed said tacks between said driving mechanism and said channel; and

a spring engaging said tack cartridge and surrounding a portion of said driving pin such that said spring provides a force
to maintain contact between said shaft lip and said handle lip,

wherein said driving pin is movable between a first position in which said driving pin engages one of said tacks within said
passageway and a second position in which said driving pin engages said one of said tacks within said channel.

US Pat. No. 9,066,761

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. An extender comprising:
a first extension including a first wall and extending between a proximal end and a distal end, the first wall defining an
axial cavity including a distal portion having a first dimension, an intermediate portion having at least one ramp and a proximal
portion having a second dimension, the first dimension being greater than the second dimension, the distal end including at
least one fixation surface;

a second extension extending from adjacent the proximal end of the first extension to a distal end of the second extension,
the distal end including a projection; and

an actuator fixed with the second extension, the proximal end of the first extension including a threaded outer surface, the
actuator including an inner surface having a first threaded surface engageable with the threaded outer surface to cause axial
translation,

wherein the first extension is configured for axial translation relative to the second extension such that the projection
is disposable in the axial cavity in a first position such that the projection is disposed with the distal portion of the
axial cavity and the distal end of the first extension is disposed in a non-expanded orientation, and the projection is slidably
engageable with the at least one ramp for movement to a second position such that the projection is disposed with the proximal
portion of the axial cavity and the distal end of the first extension is disposed in an expanded orientation.

US Pat. No. 9,056,150

COMPOSITIONS FOR TREATING BONE DEFECTS

Warsaw Orthopedic, Inc., ...

1. A medical implant composition, comprising:
a malleable mechanically entangled mass of elongate, compliant noncollagenous scaffolding elements composed of one or more
synthetic polymers, forming a loaded scaffolding material, the mechanically entangled mass having an osteoconductive calcium-containing
particulate material incorporated therein, said scaffolding material comprising between 11% by weight of said composition
and 50% by weight of said composition;

a biodegradable barrier substance coating the exterior surface of the loaded scaffolding material;
sulfated glycosaminoglycan molecules bound to said scaffolding elements; and
a liquid organic binder coating said scaffolding elements comprising an aqueous medium comprising an alginate polymer having
an average molecular weight ranging from 2 to 100 kD and more than 50% alpha-L-guluronic acid, said liquid organic binder
having a viscosity in a range from about 1 centipoise to about 200 centipoises and being present in an amount that is effective
to increase the cohesivity of said mechanically entangled mass,

wherein said liquid organic binder comprises about 60% to about 75% by total weight of said composition.

US Pat. No. 9,186,197

NERVE AND SOFT TISSUE ABLATION DEVICE FOR TREATING PAIN

Warsaw Orthopedic, Inc., ...

1. A cryoablation device comprising: a probe having an exterior and an interior, the exterior comprising a tip and the interior
defining a passage having a filament and insulation disposed therein, the filament configured to conduct a pressurized material
at a temperature from ?180° C. to about 0° C. and having an opening configured to release the pressurized material into the
interior of the probe so as to cool the tip to a selected temperature to ablate nerve and/or soft tissue; and a bone piercing
instrument, the bone piercing instrument configured to pierce bone so as to allow entry of the probe into the bone, and a
pressure of the pressurized material is from about 3,000 to about 6,000 pounds per square inch (PSI).

US Pat. No. 9,375,240

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A sleeve extending along a longitudinal axis between a first end and a second end, the sleeve including a first arm, a
second arm and an inner surface defining an interior cavity therebetween, the first end comprising a smooth outer surface,
the smooth outer surface extending from a proximal end surface of the first end to the arms, each of the arms including a
radially flexible tab having an inward projection, wherein each of the tabs is resiliently biased in a direction that faces
the other tab such that the sleeve is movable between a first orientation in which the projections are spaced apart a first
distance and a second orientation in which an outward force is exerted on each tab such that the projections are spaced apart
from one another a second distance that is greater than the first distance, wherein each tab has a convex end surface extending
between planar sidewalls and a uniform width between the sidewalls and the convex end surface has a maximum width that is
equal to the width of the tab.
US Pat. No. 9,358,323

FLOWABLE CERAMIC PUTTY

Warsaw Orthopedic, Inc., ...

1. A bone void filling composition, comprising: an aqueous admixture of ceramic particles; a polysaccharide comprising alginate;
a therapeutic agent; a thermosetting polymer comprising a reverse Poloxamer; and a porogen, wherein the polysaccharide and
ceramic particles are present in ratio of between about 1:1 to about 1:20 by dry weight, and the porogen is organic and has
a particle size of from about 120 to about 400 microns, and a film of cross-linked alginate surrounding the bone void filling
composition, and the bone void filling composition comprises a viscosity enhancing agent.
US Pat. No. 9,125,917

FLUOCINOLONE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER

Warsaw Orthopedic, Inc., ...

1. An implantable drug depot for reducing or treating pain, inflammation, and/or tissue transplant rejection in a patient
in need of such treatment, the implantable drug depot comprising fluocinolone or a pharmaceutically acceptable salt thereof
in an amount from about 0.5 wt. % to about 25 wt. % of the drug depot, and at least one biodegradable polymer having an inherent
viscosity of 0.6 dL/g to 0.8 dL/g comprising poly(lactide-co-glycolide), D-lactide, D,L-lactide, L-lactide, D,L-lactide-caprolactone,
or D,L-lactide-glycolide-?-caprolactone or a combination thereof, wherein the drug depot is implanted by injection and has
a surface that releases a burst dose of the fluocinolone or the pharmaceutically acceptable salt thereof in an amount of 0.001
?g to 5 ?g within 24 hours at a site beneath the skin, and the depot releases an effective amount of the fluocinolone or a
pharmaceutically acceptable salt thereof over a period of at least fifty days, and the drug depot has a modulus of elasticity
from about 2×105 dynes/cm2 to about 5×105 dynes/cm2, and a particle size from about 10 to about 200 micrometers, and the drug depot further comprises mPEG.

US Pat. No. 9,055,936

OVER DILATION

WARSAW ORTHOPEDIC, INC., ...

1. A surgical dilation system, comprising:
a dilator having an outer tubular member and an inner tubular member sized to be movably received within an inside diameter
of said outer tubular member, said outer tubular member including a vertical slot running through a side of said outer tubular
member, said inner tubular member having an upper portion and a lower portion; and

a retractor having a proximal end including at least one mounting member protruding outwardly from a side surface of said
retractor and a distal end including at least one fanned blade protruding outwardly from said side surface, wherein when said
inner tubular member is oriented in a first position said vertical slot is in a closed state prohibiting said mounting member
from allowing said retractor to be completely introduced within said dilator, when said inner tubular member is oriented in
a second position said mounting member is permitted to travel downwardly a predetermined distance in said vertical slot, and
when said inner tubular member is positioned in a third state said mounting member is permitted to freely travel through said
vertical slot such that said dilator can be removed from a patient thereby leaving said retractor inserted into said patient.

US Pat. No. 9,358,113

DELIVERY SYSTEM

Warsaw Orthopedic, Inc., ...

1. A delivery system for delivering substances to a surgical site comprising:
a porous mesh covering comprising a biodegradable polymer, and a first compartment and a second compartment defined and formed
from the mesh covering;

a first substance comprising fully demineralized bone fibers provided in the first compartment; and
a second substance comprising surface demineralized bone chips provided in the second compartment;
wherein the mesh covering retains the first substance and the second substance for placement at the surgical site and facilitates
transfer of the first substance and the second substance or of surrounding materials, actively or passively through the mesh
covering, upon implantation, wherein the second compartment is disposed adjacent to the first compartment, and the biodegradable
polymer comprises at least one of poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and poly(lactic-co-glycolic acid) (PLGA).

US Pat. No. 9,237,907

SPINAL CORRECTION SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal correction construct comprising:
a first member defining a first longitudinal axis and configured for attachment to a first portion of vertebral tissue, the
first member having a first end and a second end;

a second member defining a second longitudinal axis and configured for attachment to a second portion of the vertebral tissue
spaced from the first portion, the second member having a first end and a second end; and

a third member defining a third longitudinal axis and having a non-flexible configuration relative to the first and second
members and being configured for attachment to an apical portion of the vertebral tissue and along at least a portion of at
least two vertebra, the third member extending between a first end connected to a first transition configured for attachment
to the first vertebral tissue and a second end connected to a second transition configured for attachment to the second vertebral
tissue,

wherein the second end of the first member is attached with the first transition and the first end of the second member is
attached with the second transition, and

wherein the first and second members each include a tether and the third member includes a spinal rod.
US Pat. No. 9,242,004

METHODS FOR PREPARING POLYMERS HAVING LOW RESIDUAL MONOMER CONTENT

Warsaw Orthopedic, Inc., ...

1. A method for preparing at least two polymers having a residual monomer content of less than 5%, the method comprising mixing
the at least two polymers in a solvent to form a polymeric mixture, the at least two polymers having similar solubilities
in the solvent, the polymeric mixture comprising at least one residual monomer and the polymeric mixture maintained at a pH
in the range from 4-6, wherein the at least two polymers comprise a first polymer that is polylactide (PLA) and a second polymer
that is polyglycolide (PGA) and wherein the polymeric mixture contains more PLA than PGA; and adding an antisolvent to the
polymeric mixture so as to separate the at least two polymers from the polymeric mixture, the antisolvent maintained at a
pH of about 7, wherein the residual monomer is soluble in the antisolvent and the at least two polymers are insoluble in the
antisolvent.

US Pat. No. 9,220,598

DELIVERY SYSTEMS, TOOLS, AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. A tool comprising:
a biodegradable polymer covering material; and
an elongated body extending between a first end and a second end, the first end including a handle, the second end including
an insertion head configured to receive the covering material and configured for compressing and shaping the covering material
in another direction such that the covering contacts endplates of a disc space, the elongated body including a suture retaining
mechanism that is spaced apart from the handle and the insertion head,

wherein the covering material is folded over an outer surface of the insertion head and is connected to the suture retaining
mechanism, and a bone graft material comprising fully demineralized bone fibers and surface demineralized bone chips is disposed
within the biodegradable polymer covering material, and the suture retaining mechanism comprises a first aperture and a second
aperture, the covering material extends between a first end and a second end, the first and second ends of the covering material
each including a pair of sutures extending therefrom, wherein two of the sutures are positioned in the first aperture and
two of the sutures are positioned in the second aperture.

US Pat. No. 9,144,439

VERTEBRAL RODS AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. A vertebral rod assembly comprising:
a first rod section defining a longitudinal axis;
a second rod section spaced from and coaxial with the first rod section, the sections each having a circular cross sectional
shape;

an intermediate section attached to each of the rod sections, the intermediate section defining a first portion of a pocket,
the first portion of the pocket having a concave inner surface and being offset from the longitudinal axis; and

an elastic bumper removably disposed in the pocket such that the elastic bumper engages the concave inner surface,
wherein the intermediate section and the elastic bumper are configured to provide variable resistance to movement of the first
and second sections.

US Pat. No. 9,597,124

SPINAL CORRECTION SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal construct comprising:
at least one spinal implant configured to be connected with vertebrae; and
a member extending between a first end and a second end configured for connection with the at least one spinal implant, the
member extends along a first plane and includes a clip extending laterally from the first end in a second plane oriented transverse
to the first plane, the clip includes inwardly biased arms for capturing tissue of a rib cage, wherein the clip is configured
for movement between an expandable orientation to receive tissue and a contracted orientation to capture tissue,

wherein a plate defines an opening configured for disposal of a bone fastener of the at least one implant,
wherein the at least one implant includes a spinal rod connected with the bone fastener, and
wherein the spinal construct further comprises a cover engageable with the plate and the bone fastener to attach the spinal
rod with the bone fastener.

US Pat. No. 9,387,197

METHODS FOR TREATING CONDITIONS SUCH AS DYSTONIA AND POST-STROKE SPASTICITY WITH CLONIDINE

Warsaw Orthopedic, Inc., ...

1. An implantable drug depot for reducing, preventing or treating dystonia and/or post-stroke spasticity in a patient in need
of such treatment, the drug depot comprising at least one biodegradeable polymer and clonidine or a pharmaceutically acceptable
salt thereof in an amount from about 0.1 wt. % to about 30 wt. % of the drug depot, wherein the drug depot has a surface that
has an initial burst release of about 5 wt. % to about 35 wt. % of the clonidine or pharmaceutically acceptable salt thereof
over a first period of between about 24 and 48 hours and is capable of releasing clonidine over a period of 5 to 135 days,
the at least one biodegradable polymer comprising poly(D,L-lactide-co-caprolactone), poly(L-lactide-co-caprolactone), poly(D,L-lactide),
or a combination thereof, the drug depot having an inherent viscosity of about 0.45 dL/g to about 0.55 dL/g.

US Pat. No. 9,364,583

OSTEOINDUCTIVE DEMINERALIZED BONE IMPLANT

Warsaw Orthopedic, Inc., ...

1. A bone graft delivery device comprising: a porous biodegradable graft body for inducing bone growth at a surgical site,
the porous biodegradable graft body having demineralized bone matrix (DBM) fibers disposed within the porous biodegradable
body, and DBM powder disposed on and adhering to the DBM fibers, the DBM powder having a particle size of about 25 to about
95 microns, wherein the porous biodegradable graft body facilitates transfer of cells into and out of the porous biodegradable
graft body to induce bone growth at the surgical site, and an adhesive to cause the DBM powder to adhere to the DBM fibers,
wherein the adhesive does not contain collagen.

US Pat. No. 9,351,959

ALPHA ADRENERIC RECEPTOR AGONISTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE

Warsaw Orthopedic, Inc., ...

1. A method of treating pain and/or inflammation from a degenerative disc and/or facet joint in a patient in need of such
treatment, the method comprising administering one or more biodegradable drug depots comprising a therapeutically effective
amount of an alpha adrenergic agonist at or near the degenerative disc and/or facet joint, the one or more biodegradable drug
depots comprising a biodegradable polymer comprising poly (lactide-co-glycolide) (PLGA), polylactide (PLA), polyglycolide
(PGA), D-lactide, D,L-lactide, L-lactide, D,L-lactide-caprolactone, D,L-lactide-glycolide-caprolactone or a combination thereof,
and having an inherent viscosity from about 0.45 dL/g to about 0.55 dL/g, wherein the drug depot releases an effective amount
of the alpha adrenergic agonist over a period of at least 1 day.

US Pat. No. 9,198,758

DELIVERY SYSTEMS

Warsaw Orthopedic, Inc., ...

1. A delivery system comprising a covering having at least one compartment comprising an elongated containment portion having
a first end and a second end opposite each other, a top surface comprising a hole having a diameter between about 1 mm and
about 10 mm, a bone material disposed within the covering, a bioactive agent disposed within the at least one compartment,
at least two access ports coupled to the at least one compartment and contacting or adjacent to the bone material, the at
least two access ports being oppositely positioned and offset from one another, the access ports configured to receive first
and second needles, the bone material comprising fully demineralized bone matrix fibers and surface demineralized bone chips
in a 30:60 ratio, the at least one compartment configured to receive the bioactive agent from the at least two access ports
for mixing with the bone material prior to delivery of the delivery system to a surgical site, and either the first end or
the second end or both ends of the elongated containment portion comprise a draw string sealing mechanism disposed about the
perimeter of either the first end or the second end or both ends, and a ratio of the covering to the bone material is about
1:50 by weight.

US Pat. No. 9,198,707

NERVE AND SOFT TISSUE ABLATION DEVICE AND METHOD

Warsaw Orthopedic, Inc., ...

1. An ablation device for ablating unwanted one of nerve tissue and soft tissue at a surgical site within a patient, the ablation
device comprising:
a probe configured to generate pressure and temperature for ablating the unwanted one of the nerve tissue and the soft tissue
at the surgical site within the patient, the probe comprising at least two prongs, each prong of the at least two prongs including
at least an exterior surface and a distal tip, each prong of the at least two prongs being configured to control at least
a temperature of each respective exterior surface to achieve an ablation temperature on each respective exterior surface,
the ablation temperature being adapted to ablate the unwanted one of the nerve tissue and the soft tissue at the surgical
site within the patient; and

at least one monitoring device coupled to the probe for recording and regulating temperature, pressure and position of the
probe;

wherein the distal tips of at least two prongs are configured to define, in combination, a probe geometry substantially matching
an anatomical tissue geometry of the unwanted one of the nerve tissue and the soft tissue at the surgical site within the
patient.

US Pat. No. 9,119,683

INTERSPINOUS IMPLANT WITH OVERLAPPING ARMS

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:
a first arm having opposing first and second ends;
a second arm having first and second ends, the second arm positioned across the first arm; and
a ball joint positioned along intermediate sections of the arms and formed by first and second extensions on opposing sides
of one of the first and second arms positioned respectively in first and second sockets defined by first and second inner
surfaces of the other arm, the first and second inner surfaces being spaced apart from one another, one of the first and second
arms including a gap formed between opposing fingers that extends inward from a first end of the arm to at least the ball
joint with the other arm positioned within the gap;

the first and second arms pivotal about the ball joint between first and second orientations with the first ends of each of
the arms and the second ends of each of the arms positioned a greater distance apart in the first orientation than in the
second orientation.

US Pat. No. 9,072,560

IMPLANT REMOVAL AID FOR USE WITH IMPLANTS UTILIZING A DATA CARRIER

Warsaw Orthopedic, Inc., ...

1. A medical device storage system comprising:
at least one medical device;
at least one data carrier comprising a proximal end and a distal end including a distal portion, the data carrier including
an enlarged substantially planar portion at the proximal end and a wall defining an opening, the substantially planar portion
comprising opposite top and bottom surfaces that are connected by a side surface of the substantially planar portion, the
substantially planar portion comprising a first lobe and a second lobe that are connected to each other at the distal portion,
planar end surfaces of the first and second lobes engage one another, the at least one medical device being disposed in the
opening such that the wall and the distal portion define an enclosure that extends completely around a proximal portion of
the at least one medical device;

a storage device comprising one or more cavities, the medical device being received in one of the cavities, the storage device
including a ledge and an inner surface defining a cut-out extending through opposite top and bottom surfaces of the storage
device, the data carrier being received in the cut-out such that the side surface engages the inner surface,

wherein pushing one side of the data carrier through the cutout causes the data carrier to pivot against the ledge such that
an opposite side of the data carrier rises up to allow the data carrier to be released from the storage device.

US Pat. No. 9,247,976

MULTI-THREAD BONE SCREW AND METHOD

Warsaw Orthopedic, Inc, ...

1. A bone screw configured to enter into tissue having a first hardness and a second hardness, the bone screw comprising:
a threaded shank extending along a longitudinal axis between a distal end portion and a proximal end portion, said threaded
shank defining a first threaded section extending from said distal end portion toward said proximal end portion, said threaded
shank defining a second threaded section extending contiguously from said first threaded section toward said proximal end
portion, said second threaded section comprising a finer thread pattern relative to said first threaded section, wherein said
threaded shank includes a first helical threading having a single thread type extending along said threaded shank from said
first threaded section and into said second threaded section, said threaded shank including a second helical threading interleaved
with said first helical threading to define said second threaded section, each of said first and second helical threadings
having a substantially equal thread pitch,

a head portion extending from said proximal end portion of said threaded shank, said bone screw being coaxial with said longitudinal
axis from said proximal end portion to said head portion, said head portion being configured to have a spinal implant coupled
thereto, wherein said head portion comprises a pair of spaced apart arms defining a U-shaped channel therebetween and said
spinal implant comprises a spinal rod that is configured to be captured within the U-shaped channel, and

a set screw having a threaded outer surface, wherein inner surfaces of said arms are threaded and are configured to engage
the threaded outer surface to couple said set screw to said head portion,

wherein said bone screw is configured for insertion into an inner region of said tissue having said first hardness and an
outer region of said tissue having said second hardness, said second hardness being greater than said first hardness, said
bone screw being configured for insertion into said tissue such that said first threaded section penetrates said inner region
after said first threaded section penetrates said outer region.

US Pat. No. 9,155,566

ADJUSTABLE BONE ANCHOR ASSEMBLY

Warsaw Orthopedic, Inc., ...

1. An orthopedic medical apparatus comprising:
a receiver member defining a longitudinal passageway having upper and lower portions extending along a longitudinal axis,
said lower portion including a pair of opposed substantially flat internal surfaces extending generally along said longitudinal
axis, said receiver member defining a channel transversely intersecting said upper portion and configured for receipt of an
elongated member;

a crown member positioned within said lower portion, said crown member having an interior region at least partially bound
by an interior lower surface, said crown member including a pair of opposite substantially flat external surfaces positioned
adjacent and arranged substantially parallel with said pair of opposed substantially flat internal surfaces of said receiver
member; and

a bone anchor member having a head portion and a bone engaging portion extending from said head portion, said head portion
at least partially positioned within said interior region and said longitudinal passageway, said head portion including an
upper surface positioned proximately adjacent said interior lower surface; and

wherein said receiver member, said crown member and said bone anchor member cooperate to substantially limit pivotal movement
of said bone anchor member relative to said receiver member within a single plane.

US Pat. No. 9,107,751

INJECTABLE AND MOLDABLE BONE SUBSTITUTE MATERIALS

Warsaw Orthopedic, Inc., ...

1. A composite osteoimplant comprising:
a plurality of particles comprising an inorganic material, a bone substitute material, a bone-derived material, or any combination
thereof; and

a polymer with which the plurality of particles has been combined;
wherein the composite is moldable at a temperature greater than about 40° C. and settable on implantation into bone at a temperature
of about 37° C.

US Pat. No. 9,358,223

FORMULATION FOR PREVENTING OR REDUCING BLEEDING AT A SURGICAL SITE

Warsaw Orthopedic, Inc., ...

1. A method of preventing or treating bleeding at a surgical site in a patient, the method comprising implanting one or more
biodegradable polymer drug depots comprising a therapeutically effective amount of a clonidine or a pharmaceutically acceptable
salt thereof locally to the surgical site to prevent or treat bleeding at the surgical site, wherein the one or more biodegradable
polymer drug depots releases an effective amount of the clonidine over a period of at least 3 days following a surgical procedure
to treat or prevent bleeding at the surgical site.

US Pat. No. 9,307,971

SURGICAL RETRACTOR INSTRUMENT SYSTEMS AND METHODS OF USING THE SAME

Warsaw Orthopedic, Inc., ...

1. A retractor system for percutaneous surgery in a patient, comprising:
a first connection assembly comprising a first lever assembly and a first retractor portion including a proximal end and a
distal end positionable in an incision, said first retractor portion including a concave inner surface and a convex outer
surface opposite said inner surface;

a second connection assembly comprising a second lever assembly and a second retractor portion including a proximal end and
a distal end positionable in the incision opposite the first retractor portion, said second retractor portion including a
concave inner surface facing said inner surface of said first retractor portion and a convex outer surface opposite said inner
surface of said second retractor portion, said first and second retractor portions defining a first axis extending therebetween,
said first and second lever assemblies being operable to rotate said first and second retractor portions about their proximal
ends to move their distal ends away from each other;

a controller in communication with said first and second retractor portions, wherein said first and/or second retractor portions
is responsive to said controller to cause movement of said first and said second retractor portions between a first position
in which the retractor portions are parallel and a second position in which the retractor portions are transverse independent
of the lever assemblies;

at least one pressure sensor configured to sense pressure applied to tissue that engages said first and second retractor portions
and being configured to generate a sensor signal representative of said pressure;

a timing circuit in communication with said at least one pressure sensor; and
a separation instrument defining a separation axis and engaging first and second connection members that extend from said
first and second connection assemblies, said separation instrument being operable to move said retractor portions toward one
another and away from one another along the first axis without said separation instrument rotating about said separation axis.

US Pat. No. 9,283,019

FLEXIBLE GUIDE WIRE

Warsaw Orthopedic, Inc., ...

1. A method of introducing a flexible guide wire to a pedicle of a vertebra of the spinal column to allow for the introduction
of a bone drill, bone tap, implant driver, and a threaded spinal implant over the guide wire and to the pedicle, comprising:
creating an incision in the body to provide access to a pedicle of a vertebra;
preparing a flexible guide wire to be introduced through the incision, the flexible guide wire comprising: a flexible wire
with a proximal end and a distal end, and a distal tip attached to the distal end of the flexible wire, the distal tip attachable
to the pedicle, wherein the distal end of the flexible wire is provided with a calibrated breaking point adjacent the distal
tip;

passing a removable sheath having a proximal end and a distal end over the flexible wire such that the sheath extends from
the proximal end to the distal end of the flexible wire and the sheath distal end is in contact with the distal tip of the
flexible guide wire;

introducing the flexible guide wire and sheath through the incision to attach the distal tip of the flexible guide wire to
the pedicle, applying an axial force to the sheath and the distal tip in a distal direction to embed the distal tip in tissue;

removing the sheath from about the flexible wire leaving the flexible wire and distal tip attached to the pedicle;
pulling the flexible wire taut from the proximal end of the flexible wire;
introducing the bone drill over the flexible wire to the pedicle to create a hole through the pedicle and into the vertebral
body, then removing the bone drill;

guiding the bone tap over the flexible wire into the hole to create a threaded hole, then removing the bone tap;
introducing the threaded spinal implant over the flexible wire;
threading the threaded spinal implant through the pedicle and into the vertebral body with the implant driver; and
removing the flexible wire from the pedicle by sharply pulling on the proximal end of the flexible wire to dislodge the distal
tip from the pedicle.

US Pat. No. 9,266,824

METHODS AND COMPOSITIONS FOR MAKING AN AMINO ACID TRIISOCYANATE

Warsaw Orthopedic, Inc., ...

1. A method of making an amino acid triisocyanate, the method comprising reacting an amino acid trihydrochloride with phosgene
to form the amino acid triisocyanate, wherein the phosgene is formed from triphosgene in the presence of a catalyst comprising
phenanthroline.

US Pat. No. 9,241,743

BONE SCREW EXTENDER REATTACHMENT SYSTEM AND METHODS

Warsaw Orthopedic, Inc., ...

1. A bone screw extender reattachment system comprising:
a bone screw comprising a receiver and a shank including a head;
a screw extender assembly comprising an inner sleeve, an outer housing and an extender head, the inner sleeve being coupled
to the receiver and positioned within the outer housing, the outer housing comprising spaced apart arms, the extender head
being positioned over the outer housing and comprising a locking tab configured to move between an unlocked position in which
the outer housing is movable relative to the receiver and a locked position in which the arms engage the receiver such that
the outer housing is fixed relative to the receiver;

an elongated reattachment rod having a proximal end and a distal end, the distal end having a tip configured to contact the
head of the bone screw, the screw extender assembly being configured to slide over the reattachment rod; and

a tension plunger having a plunger-type head and an elongated shaft configured to communicate with the screw extender assembly,
the tension plunger being positioned over the inner sleeve such that the tension plunger contacts a ledge of the inner sleeve
and an inner diameter of the outer housing.

US Pat. No. 9,066,816

SPINAL NUCLEUS REPLACEMENT IMPLANTS

Warsaw Orthopedic, Inc., ...

1. An intervertebral prosthesis apparatus implantable within a disc space, disposed between upper and lower vertebral endplates,
via an opening in the annulus extending around the disc space, comprising:
a first module comprising a generally L-shaped configuration comprising at least three planar surfaces; and
a second module comprising a generally L-shaped configuration comprising at least three planar surfaces;
wherein the first and second modules are insertable through the opening into the disc space, the at least three planar surfaces
of the first module and the at least three planar surfaces of the second module being complementarily-shaped and sized and
configured to engage within the disc space in a manner that the first and second modules form an assembled prosthesis of a
size substantially preventing it from being outwardly expelled from the disc space through the opening, the first and second
modules having bearing surfaces slidably engageable with the endplates to permit articulation between upper and lower vertebral
endplates.

US Pat. No. 9,283,089

INTERBODY BONE IMPLANT DEVICE

Warsaw Orthopedic, Inc., ...

1. An expandable implant device for implantation at a surgical site, the implant device comprising: a top piece and a bottom
piece, the bottom piece comprising bone material insertable into a disc space, the bottom piece having superior and inferior
surfaces and a longitudinal axis, said bottom piece configured to couple with the top piece comprising cortical bone and having
superior and inferior surfaces and a longitudinal axis, the bottom piece having a flat leading end face perpendicular to the
longitudinal axis of the bottom piece and the superior surface of the bottom piece having a ramped portion extending at an
incline relative to the longitudinal axis of the bottom piece and a non-ramped portion extending parallel to said longitudinal
axis, the ramped portion extending only partially along the length of the superior surface such that the leading end face
of the bottom piece comprises a greater height than an opposite end face of the bottom piece, the top piece having a leading
bullet-shaped end, the leading bullet-shaped end of the top piece configured to distract open an intervertebral disc space
by slidably inserting the top piece over the bottom piece, the inferior surface of the top piece having a ramped portion such
that the leading end of the top piece comprises a lesser height than an opposite end of the top piece, the implant device
is configured to contact host bone and the implant device comprises non-bone material, a contact surface area of the non-bone
material and the cortical bone to the host bone comprising from about 5% to about 50% of the implant, wherein the superior
surface of the bottom piece comprises a first pair of angled surfaces extending from the superior surface, the first pair
of angled surfaces forming a triangular valley extending longitudinally along the superior surface and the inferior surface
of the top piece comprises a second pair of angled surfaces extending from the inferior surface, the second pair of angled
surfaces forming a triangular peak extending longitudinally along the inferior surface, the triangular valley and triangular
peak configured to interlock with each other.

US Pat. No. 9,168,327

BONE/COLLAGEN COMPOSITES AND USES THEREOF

Warsaw Orthopedic, Inc., ...

1. A composition comprising:
approximately 10% to approximately 50% by weight of pressure treated collagen, wherein the pressure treated collagen is cross-linked
using a citric acid derivative under a compressive force of at least approximately 40 MPa, and the composition is load bearing
and has a wet compressive strength of from about 7 MPa to about 52 MPa;

harvested bone including a linker configured to facilitate interactions with the pressure treated collagen; and
the citric acid derivative.

US Pat. No. 9,078,671

SURGICAL TOOL

Warsaw Orthopedic, Inc., ...

22. A surgical tool for implanting devices within the body comprising:
a housing comprising a distal end, a proximal end opposite of the distal end, and a housing length defined as the distance
between the proximal end and the distal end;

a battery pack contained within the housing;
a motor;
an output shaft having a proximal end and a distal end opposite the proximal end, wherein the proximal end is connected to
the motor;

a segmented passage comprising a first portion disposed within an interior of the output shaft and a second portion extending
through an interior of the battery pack, the first portion extending parallel to the second portion, the first and second
portions being axially separated by an opening;

a chuck having a distal end and a proximal end opposite the distal end connected to the distal end of the output shaft; and
a handle connected to the housing and extending at an angle from the housing between the distal end and the proximal end,
the handle having a front surface including a trigger and a back surface opposite the front surface, wherein a cradle distance
defined as a distance between the back surface and the proximal end of the chuck is not greater than about 50% of the housing
length

an assembly configured to select between forward and reverse drive positions, the assembly comprising a sleeve having an inner
surface defining a lumen, the lumen having a member rotatably disposed therein, the member comprising a first pin that faces
toward the battery pack, the first pin being configured to engage openings in an anti-backdrive assembly of the tool, thereby
acting as a clutch configured to lock pawls within the anti-backdrive assembly in a particular location, the member comprising
an inner surface defining a channel, the output shaft extending through the lumen and the channel.

US Pat. No. 9,066,751

INSTRUMENTATION AND METHOD FOR MOUNTING A SURGICAL NAVIGATION REFERENCE DEVICE TO A PATIENT

Warsaw Orthopedic, Inc., ...

1. A method of mounting a surgical navigation reference device to a patient for performing an image-guided surgical procedure
adjacent the patient's spinal column, comprising:
providing a bone anchor;
anchoring the bone anchor to bone at a location remote from the patient's spinal column;
coupling the reference device to the bone anchor to mount the reference device in a substantially fixed position relative
to the patient's spinal column; and

performing an image-guided surgical procedure adjacent the patient's spinal column.
US Pat. No. 9,060,978

METHOD FOR TREATING AN INTERVERTEBRAL DISC DISORDER BY ADMINISTERING A DOMINANT NEGATIVE TUMOR NECROSIS FACTOR ANTAGONIST

Warsaw Orthopedic, Inc., ...

1. A method of treating an intervertebral disc disorder by inhibiting a proinflammatory agent in a patient in need of such
treatment, the method comprising administering 0.25 mg/kg to 20 mg/kg of a dominant negative tumor necrosis factor (DN-TNF)
antagonist XPRO®-1595 to a target tissue site at or near the intervertebral disc to reduce pain, inflammation, and/or tissue
destruction, wherein the proinflammatory agent comprises MMP-3, nitrous oxide, IL-1 or combinations thereof and the DN-TNF
is administered in a drug depot comprising polymers comprising poly (lactide-co-glycolide) (PLGA) and polyethylene glycol
(PEG) having a molar ratio of 4:1 and a pore forming agent, and the intervertebral disc disorder comprises disc compression,
herniated disc, bulging disc, collapsed disc, degenerative disc, back pain, inflamed nerve or combinations thereof, and the
DN-TNF antagonist is administered by a continuous infusion over 24 to 48 hours or the DN-TNF antagonist is released over at
least 3 days to 6 months.

US Pat. No. 9,283,091

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:
an implant body extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface
and a second vertebral engaging surface, the implant body further including an outer surface that defines an oblique surface;

a screw comprising a spheroid head disposed within the implant body and a post; and
a wall comprising spaced apart first and second openings and an aperture positioned between the openings, the post being disposed
within the aperture such that the wall is translatable relative to the oblique surface.

US Pat. No. 9,101,400

ROTATIONAL OFFSET OVAL VERTEBRAL ROD

Warsaw Orthopedic, Inc., ...

1. A flexible connection unit for use in a spinal fixation device comprising an elongated member having a first end portion,
a second end portion opposite the first end portion and a transition portion extending therebetween, wherein the first end
portion comprises an oval shape having a major diameter and the second end portion comprises an oval or non-oval shape, the
major diameter of the oval shape of the first end portion configured to be positioned substantially parallel to a sagittal
plane of a patient's body, wherein the major diameter of the first end portion is rotationally offset from a major diameter
of the second end portion between 1 and 180 degrees when the elongated member is in an unstressed state.

US Pat. No. 9,119,685

SURGICAL INSTRUMENT AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical instrument comprising:
a monolithic first member extending between a proximal end and a distal end, the distal end including a plurality of fingers
extending radially outward in a tapered configuration, the fingers each including an inner surface such that the inner surfaces
of the fingers jointly define a socket;

a second member extending between a proximal end and a distal end, the proximal end of the second member having a bit configuration
defined by a plurality of substantially planar side surfaces, the proximal end of the second member being configured to be
received within in the socket such that the side surfaces engage the inner surfaces to prevent rotation of the second member
relative to the first member; and

a third member having an inner surface defining a cavity, the cavity configured to receive and move the fingers of the first
member thereby fixing the first member to the second member,

wherein the first member includes a first thread form and the third member includes a second thread form, the thread forms
being engageable to fix the first member with the second member.

US Pat. No. 9,078,709

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant system comprising:
a first member comprising a proximal portion including a pair of spaced apart walls defining an implant cavity and a distal
portion including a tissue penetrating portion, each of the walls including a first end surface defining a first locking cavity,
a second end surface and an outer surface extending therebetween;

a second member including a first arm having an inner surface that defines a first cavity and a second arm having an inner
surface that defines a second cavity, the inner surface of the first arm including a first projection disposed within the
first cavity and the inner surface of the second arm including a second projection disposed within the second cavity; and

a third member including a first extension and a second extension that define a longitudinal cavity configured for disposal
of the second member, the first and second extensions being spaced apart by a transverse passageway that extends through a
bottommost end surface of the third member, the first extension having an inner surface that defines a first cavity and the
second extension having an inner surface that defines a second cavity,

wherein the third member is configured for axial translation relative to the second member between a first orientation such
that the first and second projections of the second member extend distal to the third member to engage the first locking cavities
and a second orientation such that the second end surfaces are disposed within the first and second cavities of the third
member and the first end surfaces are engaging the inner surfaces of the first and second arms,

wherein the inner surfaces of the first and second extensions are configured to directly and simultaneously engage the walls
that define the implant cavity when the third member is in the second orientation, and

wherein the system is configured to have a spinal rod positioned within the transverse passageway translate into the implant
cavity without removing the rod from the system.

US Pat. No. 9,078,712

PREFORMED DRUG-ELUTING DEVICE TO BE AFFIXED TO AN ANTERIOR SPINAL PLATE

Warsaw Orthopedic, Inc., ...

1. A drug-eluting device comprising:
an open cell drug-eluting matrix containing at least one elutable drug and at least one anti-adhesion substance that facilitates
non-irritating motion of the device across adjacent tissue; and

an anterior spinal plate comprising at least one affixation feature for providing affixation of the drug-eluting matrix to
said anterior spinal plate,

wherein said drug-eluting matrix is configured to engage a surface of said anterior spinal plate and comprises rifampin and
minocycline, wherein the rifampin and minocycline are configured to be eluted from said drug-eluting matrix towards said surface
of said anterior spinal plate, and

wherein said anterior spinal plate and said drug-eluting matrix are provided as two separately sterilized components, said
anterior spinal plate being sterilized using an autoclave and said drug-eluting matrix being sterilized using sterilizing
radiation or sterilant gas.

US Pat. No. 9,333,447

FILTRATION DEVICE

Warsaw Orthopedic, Inc., ...

1. A filtration device comprising:
an elongated housing having at least one wall defining a chamber disposed between a receiving end and a dispensing end including
an outlet to dispense;

a plunger slidably inserted within the chamber from the receiving end;
a first impermeable disc having a hole slidably receiving the plunger, said first impermeable disc being slidably and sealingly
moveable along a length of said plunger, and being slidably and sealingly movable along a length of said at least one wall
defining said chamber; and

a second disc including at least one filter, said second disc being fixed to an end of the plunger and located between the
first impermeable disc and said dispensing end, said second disc being slidably and sealingly movable along a length of said
at least one wall defining said chamber;

wherein, the shape of said discs substantially conforms to the shape of said chamber.
US Pat. No. 9,327,052

POLYURETHANES FOR OSTEOIMPLANTS

Warsaw Orthopedic, Inc., ...

1. A biodegradable polyurethane composite, comprising: a polyurethane matrix formed by reaction of a polyisocyanate with a
polyol to form a biodegradable polyurethane polymer; and a reinforcement embedded in the matrix, wherein the reinforcement
comprises a material selected from the group consisting of bone and bone substitutes.

US Pat. No. 9,247,967

ROD AND ANCHOR SYSTEM AND METHOD FOR USING

Warsaw Orthopedic, Inc., ...

1. A method comprising:
implanting an anchor into a bone, wherein the anchor comprises a receiving portion and a screw, the receiving portion comprising
a pair of spaced apart arms defining an inner surface defining a first cavity having a crown disposed therein and a U-shaped
second cavity, the screw comprising a screw head contained within the first cavity such that a portion of the screw head engages
the crown and another portion of the screw head engages the inner surface, wherein the anchor is a polyaxial screw that allows
the screw to pivot with respect to the receiving portion, the anchor comprising a ring positioned within a recess in the first
cavity that engages the screw head to retain the screw head in the first cavity, the ring being spaced apart from the crown
when the screw head and the crown are positioned in the first cavity and the ring is positioned within the recess, wherein
the receiving portion comprises a material having a greater yield strength than a material of the screw;

selecting a rod from a group of rod types, containing at least a first rod and a second rod wherein the first rod has a different
modulus of elasticity than the second rod;

positioning the first rod within the second cavity, and
selecting a set screw to secure the first rod to the receiving portion.

US Pat. No. 9,241,797

BONE DELIVERY SYSTEMS INCLUDING HOLDING AND FILLING DEVICES AND METHODS

Warsaw Orthopedic, Inc., ...

1. A delivery system comprising a biodegradable covering configured for implantation into a bone defect site, the covering
having at least one compartment, the at least one compartment defining an opening having a pre-attached closing member, a
pre-attached detachable holding member surrounding the opening of the at least one compartment and a pre-attached removable
filling member configured to fit within the opening of the at least one compartment for loading the at least one compartment
with at least one substance, wherein the pre-attached detachable holding member includes a collar, wherein the detachable
collar includes a gripping member comprising least two finger grips or finger depressions or a combination thereof.

US Pat. No. 9,308,190

METHODS AND COMPOSITIONS TO ENHANCE BONE GROWTH COMPRISING A STATIN

Warsaw Orthopedic, Inc., ...

1. An implantable medical device configured to fit at, near or in a bone defect, the medical device comprising a biodegradable
polymer, a therapeutically effective amount of a statin disposed throughout the medical device to facilitate bone growth,
and trehalose, the polymer comprising poly(DL-lactide-co-glycolide), the medical device having an inherent viscosity of about
0.34 dL/g, the statin comprising at least cerivastatin, atorvastatin, simvastatin, pravastatin, fluvastatin, lovastatin, rosuvastatin,
eptastatin, pitavastatin, velostatin, fluindostatin, dalvastain, or pharmaceutically acceptable salts thereof or a combination
thereof, wherein the medical device allows influx of at least progenitor, and/or bone cells at, near or in the bone defect.

US Pat. No. 9,173,701

RF ENABLED INFLATABLE BONE TAMP

Warsaw Orthopedic, Inc., ...

1. A device for performing a surgical procedure to ablate pathological tissue at a surgical site in a patient, the device
comprising:
an elongated shaft extending between a proximal end and a distal end, the shaft including an outer surface and an inner surface,
the shaft configured for insertion into the surgical site containing the pathological tissue and surrounding non-pathological
tissue;

an expandable member disposed at the distal end of the shaft configured to receive inflation material;
at least one electrode disposed with the expandable member, adapted to emit RF energy having a frequency sufficient for ablating
the pathological tissue at the surgical site;

a cooling mechanism including at least a spiral tube provided within the expandable member, the spiral tube configured to
receive a cooling medium therein; and

a sensor provided on the expandable member measuring temperature to determine an amount of ablation of at least one of the
pathological tissue and the surrounding non-pathological tissue, and to determine if emission of the RF energy should be continued
to further ablate the pathological tissues;

wherein the cooling medium in the spiral tube uniformly decreases the temperature of the expandable member, thereby deflating
the expandable member, and allowing at least removal of the device from the surgical site.

US Pat. No. 9,168,062

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A method for treating a spine, the method comprising the steps of:
percutaneously delivering a first fastener along a pedicle trajectory disposed in alignment with a first vertebral level of
vertebrae;

fastening the first fastener with the first vertebral level adjacent a lateral portion of the vertebrae;
percutaneously delivering a first spinal rod adjacent to the first fastener;
connecting the first spinal rod with the first fastener;
percutaneously delivering a second fastener along a cortical trajectory disposed in alignment with the first vertebral level;
fastening the second fastener with the first vertebral level adjacent a contralateral portion of the vertebrae;
percutaneously delivering a second spinal rod adjacent to the second fastener; and
connecting the second spinal rod with the second fastener,
wherein the pedicle and cortical trajectories each extend transverse relative to a sagittal plane that extends parallel to
spinous processes of the vertebrae.

US Pat. No. 9,131,975

NERVE AND SOFT TISSUE ABLATION DEVICE

Warsaw Orthopedic, Inc., ...

1. An ablation device comprising:
a probe comprising:
an outer tube having a first exterior surface, the first exterior surface comprising a proximal end and a distal end, and
a pointed tip defined at the distal end;

a first interior surface, the first interior surface defining a first internal passage, the first internal passage having
an inner tube disposed therein, the inner tube comprising a second exterior surface and a second interior surface, the second
interior surface defining a second internal passage, the second internal passage having an opening at a distal end thereof;
and

a filament disposed in the second internal passage, the filament having a distal end proximate the opening, and configured
to release a pressurized material into at least the second internal passage the pressurized material adapted to cool at least
a portion of the first exterior surface of the outer tube to a selected temperature;

wherein the ablation device further comprises an air gap between at least a portion of the second exterior surface of the
inner tube and the first internal passage so as to insulate the at least the portion of the second exterior surface from the
select selected temperature; and

wherein the pointed tip is configured for piercing, pushing through, and ablating at least one of nerve and soft tissue.

US Pat. No. 9,078,768

ARCUATE INTERBODY SPINAL FUSION IMPLANT HAVING A REDUCED WIDTH AND AN ANATOMICALLY CONFORMED TRAILING END

WARSAW ORTHOPEDIC, INC., ...

1. A spinal fusion implant for insertion into an implantation space formed into two adjacent vertebral bodies of a human spine,
said implant comprising:
a leading end for insertion into the implantation space, a trailing end opposite said leading end, a central longitudinal
axis extending through said leading and trailing ends, a length between said trailing end and said leading end along the central
longitudinal axis, said leading end being configured to facilitate insertion between the two adjacent vertebral bodies, and
said trailing end being sized and configured to fit into the implantation space between the two adjacent vertebral bodies;

opposed upper and lower arcuate surfaces connecting said leading and trailing ends, said upper and lower arcuate surfaces
including at least one opening, said openings being in communication with one another to permit for the growth of bone from
adjacent vertebral body to adjacent vertebral body through said implant, said upper arcuate surface, when said implant is
positioned in the implantation space, being oriented toward and facing an upper vertebral body of the two adjacent vertebral
bodies, and said lower arcuate surface, when said implant is positioned in the implantation space, being oriented toward and
facing a lower vertebral body of the two adjacent vertebral bodies; and

a medial side having a medial side surface and a lateral side having a lateral side surface, said medial side being configured
for placement adjacent a midline of the implantation space extending between anterior and posterior aspects of the human spine,
said implant having first width and a second width from said medial side to said lateral side in a first plane, the first
plane extending through the central longitudinal axis, through said medial and lateral sides, and through said leading and
trailing ends, said implant having a maximum height from said upper arcuate surface to said lower arcuate surface in a second
plane, the second plane bisecting the length of the implant along the central longitudinal axis, being perpendicular to the
central longitudinal axis, and extending through said upper and lower arcuate surfaces and through said medial and lateral
sides, the first width of said implant extending in the second plane and bisecting the maximum height of said implant, the
second width of said implant extending in a third plane, the third plane being positioned directly adjacent said leading end,
being perpendicular to the central longitudinal axis, and extending through said upper and lower arcuate surfaces, the medial
side surface having a first length in the first plane from the third plane to the trailing end, the lateral side surface having
a second length in the first plane from the third plane to the trailing end, the first length of said medial side surface
being greater than the second length of said lateral side surface, said trailing end being at least in part arcuate in the
first plane across more than half of the width of said implant and being arcuate in the first plane proximate an intersection
of the first plane with a fourth plane through the central longitudinal axis, through said leading and trailing ends, and
through said upper and lower arcuate surfaces, the fourth plane being perpendicular to the first, second, and third planes,
said upper and lower arcuate surfaces being at least in part arcuate in the second plane adjacent the maximum height of the
implant and adjacent the intersection of the second and fourth planes, and said implant having a maximum length along said
medial side surface measured from the third plane to said trailing end.

US Pat. No. 9,056,151

METHODS FOR COLLAGEN PROCESSING AND PRODUCTS USING PROCESSED COLLAGEN

Warsaw Orthopedic, Inc., ...

1. A medical implant comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural
collagen constituents, wherein the enzyme treatment comprises digesting the collagen with ficin and deactivating the ficin
with a non-alkaline sodium chlorite solution to maintain growth factors and morphogenic proteins otherwise stripped away by
exposure to an alkaline solution, wherein the collagen is lyophilized by exposing the collagen to a vapor phase cross-linking
agent, the cross-linking agent comprising at least one of acetaldehyde, dialdehyde starch, glycerol polyglycidyl ethers, polyethylene
glycol diglycidyl ethers, polyvalent metallic oxides, or a combination thereof, wherein the collagen comprises cartilage fragments,
a plasticizer and angiogenesis promoting factors, the angiogenesis promoting factors comprising SEMA3.

US Pat. No. 9,320,708

MEDICAL IMPLANTS WITH RESERVOIR(S)

Warsaw Orthopedic, Inc., ...

1. A medical article, comprising: a three-dimensional porous body formed of an implantable material; said three-dimensional
body being wettable with a biocompatible liquid; said three-dimensional body being disruptable upon wetting with the biocompatible
liquid so as to form a wetted, disrupted implant material; and said three-dimensional body defining one or more reservoirs
configured to receive and pool the biocompatible liquid, and the medical article comprises 50% to 75% by weight of the biocompatible
liquid, and the one or more reservoirs have a combined volume of at least about 1 cc.
US Pat. No. 9,289,409

SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL

Warsaw Orthopedic, Inc., ...

1. An implantable drug depot for reducing or treating pain and/or inflammation in a patient in need of such treatment, the
implantable drug depot comprising sulindac or a pharmaceutically acceptable salt thereof in an amount from about 20 wt. %
to about 40 wt. % based on the weight of the drug depot, and at least one biodegradable polymer comprising poly (lactic-co-glycolic
acid) capable of releasing the sulindac or a pharmaceutically acceptable salt thereof for at least 3 days, wherein the at
least one biodegradable polymer has an inherent viscosity of from 0.45 dL/g to 0.8 dL/g and the drug depot has a surface that
releases a burst dose of sulindac or a pharmaceutically acceptable salt thereof in an amount of 10% to 20% by weight based
on the total weight of the sulindac or pharmaceutically acceptable salt thereof in the drug depot within 72 hours and the
drug depot comprises an adherent gel that stiffens after delivery to a target site having a pre-dosed modulus of elasticity
of about 5×10 4 dynes/cm2 to about 1×105 dynes/cm2 and a post-dosed modulus of elasticity in the range of about 2×105 dynes/cm2 to about 5×105 dynes/cm2 and the drug depot comprises magnesium carbonate, and the drug depot further comprises a plasticizer comprising mPEG in an
amount of from about 0.05 wt. % to about 20 wt. %.

US Pat. No. 9,204,909

SPINAL ROD SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal rod system comprising:
at least one first instrument extending between a proximal portion and a distal portion along a longitudinal axis thereof,
the proximal portion defining an inner cavity extending along the longitudinal axis,

the at least one first instrument including at least one first arm extending along the longitudinal axis, the at least one
first arm includes a first leg extension and a second leg extension, the first and second leg extension each including a tapered
slot and a distal inner surface having a tapered configuration,

the at least one first arm defining at least a portion of a vertebral construct cavity disposed in communication with the
inner cavity and including a distal end being configured to engage a bone fastener;

an actuator arm movable along the longitudinal axis and comprising a distal head that tapers distally to an increased width,
the distal head being engageable with the distal inner surfaces to move the at least one first arm in a direction transverse
to the longitudinal axis between a first position and a second position such that the distal end of the at least one first
arm engages the bone fastener; and

a slide disposed with a slot at a distal end of the actuator arm to fix the slide axially relative to the actuator arm, the
slide having enlarged end portions movably disposed in the tapered slots,

wherein the actuator arm comprises an elongated portion including an aperture, the at least one first instrument comprising
a pin that is received in the aperture to connect the actuator arm with a handle, the pin extending through inner and outer
surfaces of the handle.

US Pat. No. 9,161,903

FLOWABLE COMPOSITION THAT HARDENS ON DELIVERY TO A TARGET TISSUE SITE BENEATH THE SKIN

Warsaw Orthopedic, Inc., ...

1. An implantable drug depot for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient,
the implantable drug depot comprising (i) a deployable balloon having a chamber, wherein the chamber comprises a channel and
a closure member that can close said channel; and (ii) a flowable composition comprising an effective amount of a therapeutic
agent, the composition disposed in the chamber of the balloon, wherein the flowable composition has a pre dosed modulus of
elasticity of about 1×104 to about 3×105 dynes/cm2 and is disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is
delivered at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period
of at least one day, and the drug depot comprises a polymer comprising polyethylene glycol with pendant hydroxyl groups (PEGH).
US Pat. No. 9,162,012

BONE MATRIX COMPOSITIONS AND METHODS

Warsaw Orthopedic, Inc., ...

1. An osteoinductive composition, the composition comprising: heat and gaseous supercritical carbon dioxide treated surface
demineralized bone particles, the bone particles ranging from approximately 1 mm to approximately 4 mm in their longest dimension,
and being approximately 10 to approximately 50% demineralized; demineralized bone matrix; and a delivery vehicle, and the
bone particles are surface demineralized at a depth of at least 50 microns.

US Pat. No. 9,452,183

COMPOSITIONS AND METHODS FOR TREATMENT OF HEMORRHAGE

Warsaw Orthopedic, Inc., ...

1. A method of treating a hemorrhage comprising: diagnosing one or more hemorrhaging vessels in a patient; and administering
to the patient a formulation of a vessel closing compound comprising polyethylene glycol (PEG) and an active agent comprising
magnesium having a concentration of about 0.8% weight per volume of the formulation, wherein a dose of the formulation is
administered within 30 to 90 minutes of a half-life of the PEG.

US Pat. No. 9,402,660

SURGICAL INSTRUMENT AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical instrument comprising:
a first member defining a longitudinal axis;
a second member disposed with the first member and being axially translatable relative to the first member;
a first body connected to the first member and being translatable along an arcuate path relative to the first member, the
first body being connected to a first implant support;

a second body connected to the second member and being translatable along an arcuate path relative to the second member, the
second body being connected to a second implant support; and

a first gear rack disposed with the first member and the first body such that the first body is translatable along the arcuate
path,

wherein the rack defines a first cavity disposed on a first lateral side and a second cavity disposed on a second lateral
side and the first body includes opposing flanges configured for mating engagement with the first and second cavities.

US Pat. No. 9,387,026

BONE FASTENER AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. A method for inserting a bone fastener, comprising the steps of:
puncturing bone with a distal tip of the bone fastener;
oscillating the bone fastener clockwise and counter-clockwise to axially advance the bone fastener to a first depth; and
rotating the bone fastener after the bone fastener has reached the first depth to threadingly engage bone and advance the
bone fastener to a second depth,

wherein the bone fastener oscillates clockwise and counter-clockwise as the bone fastener advances axially to the first depth.
US Pat. No. 9,504,749

MEDICAL DEVICES AND METHODS COMPRISING AN ADHESIVE SHEET CONTAINING A DRUG DEPOT

Warsaw Orthopedic, Inc., ...

1. A method of treating postoperative pain or inflammation in a patient in need of such treatment, the method comprising positioning
a medical device at or near a target tissue site beneath the skin of a patient, the medical device comprising an adhesive
sheet having an adhesive material disposed on all or a portion of the adhesive sheet, the adhesive sheet having a region including
one or more channels, holes, grooves or slits configured to receive a drug depot, the drug depot including loops, hooks, eyelets,
barbs, posts, tabs and/or clips corresponding to the one or more channels, holes grooves or slits of the region such that
the drug depot lies fixed within the region of the sheet to fix the drug depot with the sheet prior to implantation of the
medical device, and the drug depot having a therapeutically effective amount of a drug and at least one surface adapted to
release the therapeutically effective amount of the drug over a period of at least one day, and applying pressure to the adhesive
sheet and allowing the adhesive material to adhere to the target tissue site so as to limit movement of the medical device
at or near the target tissue site and wherein the sheet and the drug depot are biodegradable and the drug depot degrades slower
than the sheet.

US Pat. No. 9,387,018

SURGICAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical instrument comprising:
a first member extending along a longitudinal axis between a first end and a second end including a first jaw having a first
inner surface;

a second member comprising a second inner surface that defines a passageway having the first member disposed therein such
that the first member is rotatable relative to the second member about the longitudinal axis, the second member extending
between a first end and a second end including a second jaw having a third inner surface that faces the first inner surface
and is spaced apart from the second inner surface; and

a third member connected to the first end of the first member to relatively translate the second ends, the third member including
a part and a locking element engageable with the part,

wherein the part is disposable in a first locking orientation such that the first and third inner surfaces engage a spinal
construct, a second locking orientation such that the part disengages the locking element and is biased relative to the third
member and a non-locking orientation such that the part is moved relative to the third member and the second locking orientation
such that the first and third inner surfaces disengage the spinal construct.

US Pat. No. 9,345,547

APPARATUS AND METHOD FOR SIZING A CONNECTING ELEMENT FOR POSITIONING ALONG A BONE STRUCTURE

Warsaw Orthopedic, Inc., ...

1. An apparatus for measuring spacing between first and second bone screws engaged with first and second bone structures,
comprising:
a first arm having a distal end and a proximal end comprising a graduated scale extending therefrom;
a single pivot pin operably engaged with the first arm between the distal end and the proximal end thereof, wherein a proximal
portion of the first arm defines a first longitudinal axis and a distal portion of the first arm on the opposite side of the
single pivot pin defines a second longitudinal axis that is offset from the first longitudinal axis; and

a second arm operably engaged with the first arm via the single pivot pin, the second arm having a distal end defining a third
longitudinal axis and a proximal end defining a fourth longitudinal axis that intersects the single pivot pin, the proximal
end comprising an indicator segment slidably engaged with the graduated scale such that a position of the indicator segment
relative to the graduated scale is indicative of a spacing between the first and second bone screws, the distal portion being
movable relative to the second arm in a first plane and the proximal portion being movable relative to the second arm in a
second plane that is offset from the first plane, the proximal and distal ends of the second arm being movable relative to
the first arm in the first plane,

wherein the first arm comprises a first cylindrical element that extends along the second longitudinal axis and the distal
end of the second arm comprises a second cylindrical element that extends along the third longitudinal axis.

US Pat. No. 9,211,359

COHESIVE OSTEOGENIC PUTTY COMPRISING BONE MORPHOGENIC PROTEIN, INSOLUBLE COLLAGEN AND BIPHASIC CALCIUM PHOSPHATE

Warsaw Orthopedic, Inc., ...

1. An implantable osteogenic medical material, comprising:
a malleable, cohesive, shape-retaining putty comprising 60% to 75% by weight of an aqueous liquid medium and including a bone
morphogenic protein incorporated at a level of about 0.6 mg/cc to about 2 mg/cc of the putty;

said putty including mineral particles dispersed therein having an average particle diameter in the range of 0.4 mm to 5 mm
at a level of 0.25 g/cc to 0.35 g/cc in the putty;

said putty further including insoluble collagen fibers at a level of 0.04 g/cc to 0.1 g/cc of the putty, and soluble collagen
at a level of 0.01 g/cc to 0.08 g/cc of the putty,

wherein the mineral particles form a scaffold for bone ingrowth and comprise biphasic calcium phosphate that has a tricalcium
phosphate: hydroxyapatite weight ratio of 50:50 to 95:5.

US Pat. No. 9,155,573

SPINAL CORRECTION SYSTEM

Warsaw Orthopedic, Inc., ...

1. A spinal correction system comprising:
a first apparatus comprising a first member defining a longitudinal axis and including a first end comprising a first inner
surface that defines a first cavity and a second end comprising a second inner surface that defines a second cavity, the first
end being fixed relative to the second end, and a second member defining a longitudinal axis and including a first end comprising
a first inner surface that defines a first cavity and a second end comprising a second inner surface that defines a second
cavity, the members being connected along a first axis disposed in substantially parallel relation to the longitudinal axes
such that the first cavities are substantially aligned and the second cavities are substantially aligned;

a second apparatus comprising a first member defining a longitudinal axis and including a first end comprising a first inner
surface that defines a first cavity and a second end comprising a second inner surface that defines a second cavity, and a
second member defining a longitudinal axis and including a first end comprising a first inner surface that defines a first
cavity and a second end comprising a second inner surface that defines a second cavity, the members of the second apparatus
being connected along a second axis disposed in substantially parallel relation to the longitudinal axes of the members of
the second apparatus;

a frame configured for disposal of the first and second apparatuses;
a plurality of concave implant supports, each concave implant support configured for disposal within a respective cavity of
the first apparatus; and

a plurality of convex implant supports, each convex implant support configured for disposal within a respective cavity of
the second apparatus,

wherein the members of the first apparatus are rotatable about the first axis to space apart the members of the first apparatus
such that the inner surfaces forcibly engage the concave implant supports in releasable fixation and the members of the second
apparatus are rotatable about the second axis to space apart the members of the second apparatus such that the inner surfaces
forcibly engage the convex implant supports in releasable fixation.

US Pat. No. 9,277,943

SURGICAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:
a fastener;
a wall extending between a first end and a second end and defining a longitudinal axis, the wall having a first surface and
a second surface configured to engage tissue,

the wall defining at least one opening configured for disposal of a bone fastener,
the first end includes an inner surface comprising a first linear side and a second linear side, the linear sides being disposed
in substantial alignment with the axis, the inner surface further comprising an arcuate side connected to the linear sides
to define a cavity configured for disposal of the fastener, each of the linear sides including a flange, the fastener comprising
a threaded shaft that engages the flanges and the arcuate side to capture the fastener; and

a retaining element configured to resist and/or prevent inadvertent back out of the bone fastener from the at least one opening.

US Pat. No. 9,220,553

SYSTEM AND METHOD FOR PRESSURE MIXING BONE FILLING MATERIAL

Warsaw Orthopedic, Inc., ...

1. A bone augmentation system comprising:
a mixing vessel at least partially filled with a bone filling material, the mixing vessel comprising a mixing element, wherein
mixing the bone filling material with the mixing element creates a bone augmentation material including a plurality of voids;

a pressurization source connected to the mixing vessel and adapted to prevent at least some voids in the bone augmentation
material from escaping;

a dispensing instrument comprising a dispensing reservoir adapted to receive the bone augmentation material and comprising
a cannulated member adapted to deliver the bone augmentation material into a body region adjacent cancellous bone.

US Pat. No. 9,180,019

INTERBODY DEVICE AND PLATE FOR SPINAL STABILIZATION AND INSTRUMENTS FOR POSITIONING SAME

Warsaw Orthopedic, Inc., ...

1. A system for providing spinal stabilization, comprising:
a plate including a body having a top surface and an opposite bottom surface, the body including a superior first pair of
holes extending through the top and bottom surfaces at a cephalad end of the plate and an inferior second pair of holes extending
through the top and bottom surfaces at a caudal end of the plate, trajectories of each of the holes extending toward a common
point above the plate, the plate including a retaining element rotatably disposed on an outer surface of the plate, the retaining
element comprising a plurality of arms separated by gaps, the retaining element being rotatable between a first position where
the gaps are aligned with the holes and a second position where the arms overlap the holes.

US Pat. No. 9,427,261

SPINAL CORRECTION SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal correction apparatus comprising:
a body;
a ratchet disposed within the body;
a longitudinal element connected to the ratchet;
an actuator disposed with the body and connected to the ratchet, the actuator being rotatable relative to the body and the
ratchet to facilitate movement of the first longitudinal element relative to the body and the ratchet;

wherein the ratchet comprises a rack formed on an inner surface of the body and a carriage connected with the first longitudinal
element, the ratchet further comprising a pawl engageable with the carriage and the rack to facilitate axial movement of the
longitudinal element.

US Pat. No. 9,265,733

DRUG DEPOTS HAVING DIFFERENT RELEASE PROFILES FOR REDUCING, PREVENTING OR TREATING PAIN AND INFLAMMATION

Warsaw Orthopedic, Inc., ...

1. A method of reducing or treating pain and/or inflammation in a patient in need of such treatment, the method comprising
administering a plurality of implantable drug depots at or near a target tissue site beneath the skin of the patient, wherein
a first set of the plurality of drug depots comprises micelles capable of releasing a therapeutically effective bolus dose
of an analgesic and/or an anti-inflammatory agent or pharmaceutically acceptable salts thereof and a second set of the plurality
of drug depots comprises micelles capable of releasing a therapeutically effective amount of the analgesic and/or the anti-inflammatory
agent or pharmaceutically acceptable salts thereof over a period of at least three days, wherein the first and/or second set
of the plurality of drug depots comprises an adherent gel, the adherent gel comprising a polyethylene glycol (PEG) conjugate
or a PEG viscosity enhancing agent, and the gel has a pre-dosed modulus of elasticity in the range of about 1×104 to about 3×105 dynes/cm2 and a post-dosed modulus of elasticity in the range of about 1×105 to about 7×105 dynes/cm2.

US Pat. No. 9,402,659

SPINAL IMPLANT SYSTEM

Warsaw Orthopedic, Inc., ...

1. A surgical instrument comprising:
a first member including a first body connected to a pair of second bodies, the first body being configured for disposal of
an implant support having an outer surface and at least one of the second bodies including a capture element configured to
dispose an implant support having an outer surface with the at least one of the second bodies such that the outer surfaces
are spaced apart and each of the implant supports are engageable with a first implant, the first member comprising an elongated
member having an end that engages the first body, the end being positioned between the first body and one of the second bodies
such that the end engages one of the second bodies; and

a second member connected with the first member and engageable with a second implant,
wherein the members are relatively movable to dispose the second implant with the implant supports and in alignment with at
least one of the first implants.

US Pat. No. 9,241,722

SURGICAL PIN GUIDE AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. A surgical guide comprising:
a first component comprising a distal end and a proximal end and comprising a palpating portion and a non-palpating portion
disposed on an opposing side from the palpating portion, the palpating portion comprising a first ring defining the distal
end, a second ring defining the proximal end, and an opening defined along the palpating portion between the first and second
rings, the first component defining a channel extending therethrough; and

a second component attached to the non-palpating portion of the first component, the second component defining a guide channel
extending therethrough, the guide channel adapted to receive a guide member therethrough;

wherein the channel of the first component is adapted to receive a finger of a surgeon such that the finger extends outward
from the distal end of the first component and such that the finger is disposed between the palpating portion and the non-palpating
portion of the first component.

US Pat. No. 9,364,582

MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX

Warsaw Orthopedic, Inc., ...

1. A demineralized bone matrix (DBM) composition, comprising: bioresorbable solids admixed with a liquid carrier to form a
malleable implant composition, said bioresorbable solids present at a level of 0.1 grams per cubic centimeter to 0.7 grams
per cubic centimeter of said composition; said bioresorbable solids comprising a particulate solid collagen material and a
particulate solid DBM material, said particulate solid collagen material present in a weight ratio no less than 1:12 and no
greater than 1:2 relative to said particulate solid DBM material; and said liquid carrier comprising an aqueous gel of a biocompatible
polysaccharide comprising an alginate having more than 50% alpha-L-guluronic acid, wherein said biocompatible polysaccharide
is present at a level of 0.01 grams per cubic centimeter to 0.5 grams per cubic centimeter of said composition and comprises
a viscosity from 25 mPas to 1000 mPas, and the particulate solid DBM material comprises at least 20 weight % of DBM particles
having a maximum dimension of about 3 mm to about 5 mm and at least 20 weight % of DBM particles having a maximum dimension
of less than 1 mm.

US Pat. No. 9,364,341

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant system comprising:
an implant extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface
and a second vertebral engaging surface, the implant further including a first inner surface that defines at least a first
cavity and a second inner surface that defines a second cavity spaced from the first cavity, the first cavity being oriented
to implant a fastener oblique relative to a bilateral axis of a subject body and the second cavity being oriented to implant
a fastener in substantial alignment with the bilateral axis, the implant including a bore that extends transverse to each
of the cavities;

a member positioned in the bore such that a first through hole of the member is aligned with the first cavity and a second
through hole of the member is aligned with the second cavity, the through holes each having a circular cross section;

a plate connected with the implant via the fastener; and
a guide configured to connect the plate and the fastener with the implant along a surgical pathway.

US Pat. No. 9,050,143

SPINAL CORRECTION SYSTEM

Warsaw Orthopedic, Inc., ...

1. A spinal correction system comprising:
a bone fastener comprising a receiver defining a longitudinal axis; and
an implant support comprising:
a body comprising a housing and a tubular part that defines a central longitudinal axis,
a first member including a first portion extending through the housing and a second portion configured to engage the receiver,
the second portion extending in a transverse orientation from the first portion, and

a second member including a first portion extending through the housing and a second portion configured to engage the receiver,
the second portion of the second member extending in a transverse orientation from the first portion of the second member,

wherein at least one of the members is movable relative to the central longitudinal axis between a first configuration and
a second configuration such that the members are connected to the bone fastener and the central longitudinal axis is offset
relative to the longitudinal axis.

US Pat. No. 9,451,998

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. An extender comprising: an inner member defining a longitudinal axis and including a wall defining a thread form, the inner
member further including at least one extension defining a first axial cavity and a second axial cavity, each of the axial
cavities including a first portion, a second portion and a third portion, wherein the wall includes a first lock opening in
communication with the thread form, a second lock opening, and a third lock opening; and
an outer member including an actuator, the actuator including a protuberance, and at least one arm having a first projection
disposable with the portions of the first axial cavity and a second projection disposable with the portions of the second
axial cavity, the projections each extending directly from an inner surface of the at least one arm,

wherein the actuator is rotatable relative to the inner member so that the protuberance engages the thread form to axially
translate the inner member relative to the outer member such that the projections are disposable between a first position
in which the projections are disposed with the first portions of the respective axial cavity and the inner member is disposed
in a non-expanded orientation, a second position in which the projections are disposed with the second portions of the respective
axial cavity and the inner member is disposed in an expanded orientation, and a third position in which the projections are
disposed with the third portions of the respective axial cavity and the inner member is disposed in an expanded orientation.

US Pat. No. 9,132,085

COMPOSITIONS AND METHODS FOR TREATING POST-OPERATIVE PAIN USING CLONIDINE AND BUPIVACAINE

Warsaw Orthopedic, Inc., ...

1. An implantable drug depot useful for localized delivery to a site beneath the skin of a patient, the drug depot comprising:
a therapeutically effective amount of bupivacaine or pharmaceutically acceptable salt thereof and clonidine or pharmaceutically
acceptable salt thereof, wherein the drug depot is capable of releasing the bupivacaine or pharmaceutically acceptable salt
thereof and clonidine or pharmaceutically acceptable salt thereof over a period of at least one day, wherein the bupivacaine
is in the form of a base and the clonidine is in the form of a salt and the drug depot has a modulus of elasticity of about
2 ×104 to about 5 ×105 dynes /cm2, and wherein the drug depot comprises a polymer having an inherent viscosity of from about 0.10 dL/g to about 1.2 dL/g, and
the ratio of clonidine to bupivacaine is about 1:5, and wherein the drug depot further comprises a plasticizer comprising
mPEG.
US Pat. No. 9,359,417

CELL CULTURES AND METHODS OF HUMAN RECOMBINANT GROWTH AND DIFFERENTIATON FACTOR-5 (RHGDF-5)

Warsaw Orthopedic, Inc., ...

1. A cell culture media for growing a cell that expresses recombinant human growth and differentiation factor-5 (rhGDF-5)
protein, the cell culture media supporting growth of a cell that comprises an expression vector having a polynucleotide encoding
an rhGDF-5 protein under the control of a T5 or Trc promoter, and wherein the pH of the cell culture media ranges from about
6.5 to about 7.1, and the cell culture media does not contain glucose, and the rhGDf-5 protein comprising SEQ ID NO:4.

US Pat. No. 9,084,642

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical instrument comprising:
a first member defining a longitudinal axis and extending between a proximal end and a distal end configured to engage an
outer surface of a first implant, the distal end being movable between an expanded configuration and a contracted configuration
to engage the outer surface of the first implant;

a second member including an inner surface that defines a cavity configured for disposal of the first member, the second member
being engageable with a second implant connected to the first implant; and

an actuator connected to the first member, the actuator defining a first axis, the actuator being rotatable relative to the
longitudinal axis such that the actuator is movable between a first orientation in which the first axis is disposed at a first
angle relative to the longitudinal axis and a second configuration in which the first axis is disposed at a reduced second
angle relative to the longitudinal axis to axially translate the first member into engagement with the first implant and to
axially translate the second implant axially along the outer surface of the first implant.

US Pat. No. 9,320,559

NERVE AND SOFT TISSUE ABLATION DEVICE HAVING RELEASE INSTRUMENT

Warsaw Orthopedic, Inc., ...

1. An ablation device comprising:
a probe, the probe defining an axis and comprising an interior surface, the interior surface defining at least one internal
passage, and an exterior surface, the exterior surface comprising a probe tip, wherein the at least one internal passage includes
a filament, the filament being configured to release a pressurized material into the interior surface of the probe to cool
the exterior surface of the probe to a selected temperature, the selected temperature forming an ice ball at the probe tip,
the ice ball being adapted to ablate one of nerve and soft tissue, and wherein the at least one internal passage is configured
to recirculate the pressurized material through the probe; and

a release instrument, the release instrument comprising a sheath, the sheath including an exterior surface, a proximal end,
a distal end, the distal end including a distal edge, and an interior surface, the interior surface of the sheath being configured
for engagement with at least a portion of the outer surface of the probe, the distal edge of the release instrument being
configured to release the ice ball from the probe tip.

US Pat. No. 9,138,324

EXPANDABLE SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:
a first member including a wall that defines an axial cavity;
a second member extending between a first end and a second end and defining a longitudinal axis, the second member being configured
for disposal with the axial cavity and translation relative to the first member; and

a third member including an outer surface being engageable with tissue and an inner surface disposed to dynamically engage
the first end in response to the engagement of the outer surface with the tissue,

wherein the first end includes an outer surface that defines at least one cavity configured for movable disposal of a portion
of the third member to facilitate the dynamic engagement.

US Pat. No. 9,095,444

IMPLANT WITH AN INTERFERENCE FIT FASTENER

Warsaw Orthopedic, Inc., ...

1. A medical device for treating a patient comprising:
an implant having a maximum height defined by a distance between a superior surface and an inferior surface opposite the superior
surface, and a length defined by a distance between first and second ends that extend between the superior and inferior surfaces,
the height of the implant decreasing continuously from the first end to the second end;

a solid, non-threaded passage that extends from the superior surface through the implant to the inferior surface, the passage
having a length defined by a distance between a first end having a first diameter and a second end having a second diameter,
the first diameter wider than the second diameter, the first end extending through the superior surface and the second end
adjacent to the inferior surface, the passage having a first portion that includes the first end, and a first interference
section having a constant diameter width of the second diameter and including the second end;

a fastener with an elongated shape extending between a distal end and a proximal end, the fastener including an intermediate
portion between the distal end and the proximal end, the proximal end and the intermediate portion each being free of threads,
the distal end defining a second interference section extending along a length of the distal end and including a third diameter
that is greater than the second diameter, the intermediate portion having a maximum diameter which is less than a maximum
diameter of the distal end, the fastener comprising a helical thread extending continuously from a distal tip of the distal
end to a proximal edge of the second interference section;

one of the first and second interference sections constructed from a harder material and the other constructed from a softer
material;

a surface of the first interference section constructed from the softer material being modified by insertion of the fastener
into the passage to create an interference fit between the implant and the fastener.

US Pat. No. 10,070,871

SURGICAL TOOL

Warsaw Orthopedic, Inc., ...

1. A tool configured for removing a portion of an implant within a human comprising:a housing;
a motor contained within the housing;
a counter-torque sleeve extending along a longitudinal axis between opposite proximal and distal ends, wherein the proximal end is coupled to the housing and the distal end is configured to engage the implant;
an output shaft positioned within the counter-torque sleeve and comprising a proximal end coupled to the motor and an opposite distal end having an opening configured to engage the implant; and
an outer sleeve coupled to the housing and moveable along the longitudinal axis between a first position and a second position, the motor being in an off state when the outer sleeve is in the first position,
wherein upon a rotational force to the implant, forces transmitted by the output shaft and the counter-torque sleeve are balanced by the coupling of the output shaft and counter-torque sleeve through the housing.

US Pat. No. 9,308,296

TISSUE PROCESSING APPARATUS AND METHOD

Warsaw Orthopedic, Inc., ...

1. An apparatus for processing a biologic tissue sample, the apparatus comprising:
a controller;
an enclosure defining a reaction chamber for accepting the tissue sample, the tissue sample comprising bone material;
a reagent supply system configured to receive at least one reagent and to dispense said at least one reagent into said reaction
chamber in response to said controller;

a gas evacuation assembly communicated to said reaction chamber and configured to pump gas from said reaction chamber in response
to said controller;

a draining assembly communicated to said reaction chamber and configured to drain fluid from said reaction chamber in response
to said controller; and

a signal transmission system functionally interconnecting said controller with said reagent supply system, said gas evacuation
assembly, and said draining assembly,

wherein the controller comprises computer readable instructions to cause the controller to effect evacuation of said reaction
chamber to a predetermined pressure level by activating said gas evacuation assembly to evacuate gas from said reaction chamber
when said at least one reagent is dispensed into the reaction chamber.

US Pat. No. 9,072,546

SPINAL CONSTRUCTS WITH IMPROVED LOAD-SHARING

Warsaw Orthopedic, Inc., ...

1. A spinal construct for implantation in a patient to provide stabilization to a spinal structure with improved load sharing,
comprising:
a flexible spinal rod having a first end and a second end, the flexible spinal rod comprising a C-shaped flexible portion,
the spinal rod being configured to provide stabilization to the spinal structure;

a first bone fastener configured to securely attach to the flexible spinal rod; and
a second bone fastener configured to securely attach to the flexible spinal rod, the second bone fastener is a dynamic fastener
arranged to provide motion in one direction more than another direction, the second bone fastener is monolithic and extends
along a longitudinal axis between a proximal portion comprising a pair of spaced apart arms defining a cavity configured to
receive the flexible spinal rod and a distal portion configured to penetrate tissue, the second bone fastener includes a C-shaped
flexible portion positioned between the proximal and distal portions such that the proximal and distal portions are aligned
with the longitudinal axis and the C-shaped flexible portion includes a joint portion positioned offset from the longitudinal
axis, the flexible spinal rod and the second bone fastener are oriented to cooperate in a manner that achieves load sharing
by dynamically flexing under applied loads in a manner that distributes stresses and strains between the flexible spinal rod
and the second bone fastener.

US Pat. No. 9,517,143

ADAPTABLE INTERBODY IMPLANT AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. An intervertebral fixation implant comprising:
a body defining a longitudinal axis and extending between a first end that includes a first end surface and a second end that
includes a second end surface that is opposite the first end surface, a portion of each of the first and second walls extending
continuously from the first end surface to the second end surface, the body defining a first wall and a second wall opposite
the first wall, the first wall including a first and second lateral arms and the second wall including a third and fourth
lateral arms, the first and second lateral arms defining a first portion of a cavity therebetween and the third and fourth
lateral arms defining a second portion of the cavity therebetween, the first and third arms defining a first opening therebetween
that extends through the first end surface and the second and fourth arms defining a second opening therebetween that extends
through the second end surface, the arms being configured to collapse in the openings,

wherein the first wall is movable relative to the second wall such that the body is selectively deformable from a first, initial
implanted configuration in which the walls are spaced apart a first distance and a second configuration in which the body
is selectively deformed such that the walls are spaced apart a reduced distance relative to the first distance.

US Pat. No. 9,504,698

FLOWABLE COMPOSITION THAT SETS TO A SUBSTANTIALLY NON-FLOWABLE STATE

Warsaw Orthopedic, Inc., ...

1. A flowable composition for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient,
the flowable composition comprising (i) a solvent in an amount of about 15 wt. % of the composition, the solvent comprising
an alcoholic solution (ii) a polymer comprising repeating hydrophobic-hydrophilic polymer segments, wherein the hydrophobic
polymer segments are selected from a group consisting of poly(D,L-lactic acid), poly(L-lactic acid), poly(D-lactic acid),
poly(?-butyrolactone), poly(?-caprolactone-co-lactic acid), poly(c-caprolactone-co-glycolic acid-co-lactic acid), hydroxybutyric
acid, malic acid and poly(ethylene carbonate), and (iii) an effective amount of a therapeutic agent comprising from 1 to 30
wt %, the flowable composition being capable of increasing viscosity or developing a denser surface film to form a substantially
non-flowable composition at a physiological temperature or as the solvent contacts bodily fluid at or near the target tissue
site, wherein the flowable composition is capable of releasing the therapeutic agent over a period of at least one day and
the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near
the spinal nerve root, facet or synovial joint, or spinal canal, wherein the solvent has a Hildebrand Solubility Parameter
of at least about 7.5 or 8 (cal/cc)1/2 and the flowable composition comprises a modulus of elasticity of 2×104 to about 5×105 dynes/cm2, a predosed viscosity in the range of about 1 to about 200 cps and an inherent viscosity from about 0.10 dL/g to about 1.2
dL/g.

US Pat. No. 9,480,575

EXPANDABLE SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A method for treating a spine, the method comprising the steps of: providing a spinal implant comprising a first member
including a wall that defines a first cavity and a second member extending between a first end comprising spikes and a second
end that is disposed with the first member, the second member defining a longitudinal axis, the second member including a
wall defining a second cavity; selecting at least one first bone graft for disposal in the second cavity; axially translating
the second member relative to the first member between a first configuration and a second, expanded configuration such that
at least a portion of the at least one first graft is expanded within the first cavity and the first cavity includes a substantially
void portion; and selecting at least one second bone graft having a selective configuration and dimension for disposal within
the substantially void portion.

US Pat. No. 9,463,098

SPINAL FUSION IMPLANT WITH BONE SCREWS AND A BONE SCREW LOCK

WARSAW ORTHOPEDIC, INC., ...

1. An apparatus comprising:
an interbody spinal fusion implant for insertion at least in part into an implantation space formed across the height of a
disc space between adjacent vertebrae of a human spine, said implant comprising:

a leading end for insertion first into the disc space and a trailing end opposite said leading end, said implant having a
mid-longitudinal axis extending through said leading end and said trailing end, said implant having a length from said leading
end to said trailing end, the length of said implant being parallel to the mid-longitudinal axis;

opposed upper and lower exterior surfaces between said leading and trailing ends to contact and support the adjacent vertebrae,
said upper and lower exterior surfaces defining a maximum height of said implant, the maximum height extending between said
upper and lower exterior surfaces in a first plane perpendicular to the mid-longitudinal axis, said upper and lower exterior
surfaces of said implant including at least one opening in communication with one another for permitting for the growth of
bone from vertebra to vertebra through said implant, said upper and lower exterior surfaces of said implant including at least
one bone engaging projection for engaging the adjacent vertebrae;

opposite sides between said upper exterior surface and said lower exterior surface, and between said leading and trailing
ends, said opposite sides defining a maximum width of said implant being greater than the maximum height of said implant,
the maximum width extending between said opposite sides in a second plane perpendicular to the first plane and parallel to
the mid-longitudinal axis, each of said opposite sides having a straight portion in a direction from said leading end to said
trailing end along the length of said implant, the straight portions of said opposite sides being parallel to one another,
said leading end being at least in part curved in a third plane parallel to the second plane and having a first radius of
curvature, said trailing end being at least in part curved between said opposite sides in the third plane and having a second
radius of curvature greater than said first radius of curvature;

said trailing end having a recess including upper and lower angled interior surfaces converging in a direction toward said
leading end, said upper and lower angled interior surfaces including respective upper and lower bone screw receiving holes
passing through said upper and lower angled interior surfaces, said recess including a threaded opening spaced apart from
said bone screw receiving holes;

a plurality of bone screws configured to be inserted into said bone screw receiving holes; and
a bone screw lock for locking said plurality of bone screws, said bone screw lock having a top and a threaded portion, said
top and said threaded portion being part of unitary structure, said thread portion adapted to threadably engage said threaded
opening in said recess of said trailing end, said top being configured to cover at least a portion of each of said bone screws
to prevent said bone screws from backing out from said bone screw receiving holes.

US Pat. No. 9,427,328

INTERBODY IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. An interbody implant comprising:
a body comprising opposite top and bottom surfaces that are each configured to engage a vertebra, the body including an inner
surface defining a cavity, the cavity including a first opening that extends through the top surface and a second opening
that extends through the bottom surface; and

at least one member positioned within one of the openings so as to block a portion of one of the openings, the at least one
member having a thickness that permits bone growth therethrough and a surface configuration that resists and/or prevents egress
of bone graft from the cavity,

wherein the inner surface defines a recess that extends about the cavity, the recess including linear and arcuate portions,
the at least one member being disposed in the recess.

US Pat. No. 9,358,135

DEVICES, METHODS AND SYSTEMS FOR HYDRATING A MEDICAL IMPLANT MATERIAL

Warsaw Orthopedic, Inc., ...

1. A device for hydrating a medical implant material, comprising:
a container body defining therein a hydration chamber; and a barrier extending from one side of the hydration chamber to an
opposing side and separating the hydration chamber into a material holding area and a hydrating fluid bay,

the barrier being porous and defining a plurality of capillary apertures through which the material holding area fluidly communicates
with the hydrating fluid bay such that a hydrating fluid moves to the material holding area only by flowing through the plurality
of capillary apertures,

wherein said plurality of capillary apertures allow passage of the hydrating fluid from the hydrating fluid bay to the material
holding area,

wherein the device further comprises a removable seal effective to prevent passage of the hydrating fluid from the hydrating
fluid bay to the material holding area, the removable seal extending from the one side of the hydration chamber to the opposing
side adjacent to the barrier, the removable seal connected to a tab external to the container body, and the removable seal
and the tab configured to be pulled entirely free from the device to allow for passage of the hydrating fluid to the material
holding area,

wherein the container body is composed of a rigid material, wherein the container body comprises first and second portions
configured for alternate engagement with one another to form the hydration chamber, and disengagement from one another for
removal of a material from the material holding area,

the first and second portions being connected to one another by a hinge and a fastener,
wherein the first and second portions are separable from one another.
US Pat. No. 9,649,341

COLLAGEN MATRIX FOR TISSUE ENGINEERING

Warsaw Orthopedic, Inc., ...

1. A wound healing device comprising an active collagen matrix support material obtained from a tissue of a human, wherein
the active collagen matrix is crosslinked and contains growth factors native to the collagen in the tissue and provides a
biocompatible surface for cellular growth, the active collagen matrix comprising enzymatically removed proteoglycan groups,
the active collagen matrix including a polymer scaffold comprising a material comprising polylactide, polyglycolide, polyglycolic
acid, polylactide-co-glycolide, polylactic acid-polyethylene oxide copolymers, modified cellulose, polyhydroxpriopionic acid,
polycaprolactone, polycarbonates, polyamides and combinations thereof, wherein the support material comprises a population
of osteoblasts, chondrocytes, myocytes, cardiomyocytes, neurons or a combination thereof cultured directly on the support
material and the active collagen matrix comprises a leveling agent, wherein a surface of the active collagen matrix is treated
with a suspension of another active collagen, and the device comprises polynucleotide compositions and additional growth factors
comprising rhBMP12, BMP7, or a combination thereof, different from the growth factors native to the collagen such that the
amount of total growth factors is about 30% to about 50% greater than growth factors native to collagen, wherein the active
collagen matrix comprises particles having a size from about 25 microns to about 75 microns and the active collagen matrix
comprises native growth factors that are active, but excludes viable cells from the tissue.

US Pat. No. 9,220,539

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. An extender comprising:
a first arm defining a first longitudinal axis and including a first extension and a second extension,
the first extension including an outer surface and a projection extending from the outer surface, the projection including
a ramp and a first locking element, the first extension including an inner surface defining a longitudinal cavity, and

an actuator configured to cause axial translation of the second extension within the longitudinal cavity, wherein a cylindrical
in is inserted through an eyelet in the second extension and an opening in a locking element of the actuator such that the
locking element is pivotable relative to the first and second extensions,

wherein the projection is transversely moveable between a first configuration such that the projection extends beyond the
outer surface and a second configuration whereby the second extension axially translates within the longitudinal cavity and
engages the ramp such that the projection is disposed in alignment with the outer surface and the first locking element engages
an implant.

US Pat. No. 9,163,212

OSTEOGENIC CELL DELIVERY MATRIX

Warsaw Orthopedic, Inc., ...

1. A composition for augmenting bone formation, the composition comprising a matrix configured to allow growth of bone and/or
cartilage, the matrix having a porosity between about 50% to about 70% and comprising stem cells, calcium ions, phosphate
ions and demineralized bone matrix, the calcium ions being complexed to the phosphate ions as calcium phosphate ions, wherein
the calcium and phosphate ions are available in a quantity to have a biological effect on the stem cells, and the calcium
and phosphate ions are present in a ratio of about 1:5 to about 1:3 or about 5:1 to about 3:1.

US Pat. No. 9,055,982

SPINAL IMPLANT SYSTEM AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:
a first member extending between a first end configured for fixation with vertebral tissue adjacent a lamina and a second
end, the first member comprising a substantially arcuate intermediate portion between the first and second ends, the intermediate
portion including a surface that defines a recess configured to facilitate disposal of an instrument for engaging the lamina;

a second member extending between a first end configured for fixation with vertebral tissue adjacent the lamina and being
disposed in spaced apart relation to the first end of the first member, and a second end being connected to the second end
of the first member; and

a bone fastener,
wherein each of the second ends define a slot configured to be disposed in alignment with a spinous process, the bone fastener
extending through the slots such that the bone fastener is adapted to penetrate the spinous process to fix the spinal implant
to the spinous process prior to cutting a selected portion of the lamina and keep the spinous process in the same position
after cutting,

wherein the second ends are relatively movable in a configuration such that the members are expandable and/or contractible
the second ends each including knurled surfaces that are engageable to facilitate the relative movement.

US Pat. No. 9,848,919

SPINAL CONSTRUCT AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. A spinal construct comprising:
a first portion;
a second portion defining a longitudinal axis and being configured to penetrate tissue; and
a tether having a section positioned within the first portion such that the section is coaxial with the longitudinal axis
and a spinal implant connected with the tether is movable to a plurality of orientations relative to the longitudinal axis,

wherein the first portion defines a cavity having the section disposed therein, the first portion comprising a wall circumferentially
disposed about the cavity, the tether extending through the cavity.

US Pat. No. 9,474,559

BONE FASTENER WITH IN VIVO RESORBABLE INSULATING COATING FOR NEURO-MONITORING PURPOSES

Warsaw Orthopedic, Inc., ...

1. A bone anchor compatible for use with a neural integrity monitoring system, the bone anchor comprising:
a bone-engaging portion extending between a first end portion and a second end portion, the bone anchor comprising a thread
that extends across the first end portion, wherein the bone anchor comprises a coating that extends along an entire length
of the thread and covers upper and lower flank surfaces of the thread without covering an outer crest surface of the thread,
the coating comprising a resorbable non-electrically conductive polymer, the coating defining an insulated region of the bone
anchor, the second end portion including a conductive region of the bone anchor, the conductive region having reduced electrical
resistance relative to the insulated region, the insulated region being contiguous with the conductive region.

US Pat. No. 9,301,946

CLONIDINE AND GABA COMPOUNDS IN A BIODEGRADABLE POLYMER CARRIER

Warsaw Orthopedic, Inc., ...

1. An implantable device for reducing or treating pain in a patient in need of such treatment, the implantable device comprising
clonidine and at least one gamma-aminobutyric acid (GABA) compound comprising gabapentin in an amount from about 0.1 wt. %
to about 99 wt. % of the implantable device, a pore forming agent comprising mannitol or trehalose in an amount from about
1% to about 5% by weight, and at least one biodegradable polymer, the polymer comprising an inherent viscosity between about
0.50 dLg to about 0.70 dL/g and comprises poly(D,L-lactide), poly(D,L-lactide-co-caprolactone), poly(L-lactide-co-caprolactone)
or a combination thereof, the device configured to have a burst release of about 5% to about 25% of the clonidine within 24
hours, wherein the implantable device is capable of releasing clonidine and the GABA compound over a period of at least three
additional days, and the weight ratio of gabapentin to clonidine is 300:1.

US Pat. No. 9,283,090

SPINAL CONSTRUCT AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal construct comprising:
a first member including a first cradle that defines a first cavity and a second cradle that defines a second cavity, the
first member being configured to engage a first vertebral surface, the first cavity defining a longitudinal axis that intersects
the second cradle;

a second member including a surface that defines a first cavity and a second cavity, the second member being configured to
engage a second vertebral surface; and

at least one spacer,
wherein the members are spaced and the first cavities are disposed in substantial alignment such that at least one first rod
is disposed in the first cavities and the second cavities are disposed in substantial alignment such that a plurality of second
rods are disposed in the second cavities and spaced via the at least one spacer disposed between the second rods within at
least one of the second cavities.

US Pat. No. 9,244,060

SITE LOCALIZATION AND METHODS FOR MONITORING TREATMENT OF DISTURBED BLOOD VESSELS

Warsaw Orthopedic, Inc., ...

1. A method of determining a size of a hemorrhage of an injured tissue in a patient, the method comprising:
administering to the patient a dose of a composition comprising a labeled delivery ligand comprising polyethylene glycol (PEG)
having a molecular weight of between about 1000 DA and about 9,000 DA, wherein the polyethylene glycol comprises about 15%
to about 60% weight per volume of the delivery ligand and the composition comprises about 0.8% weight per volume of a magnesium
salt and the delivery ligand and the magnesium salt accumulate at or near the hemorrhage;

detecting the labeled delivery ligand at or near the hemorrhage;
determining an initial ratio of PEG to magnesium salt accumulated at or near the hemorrhage where the ratio of PEG to magnesium
salt is 1 to 10;

administering five additional doses of the composition; and
determining a final ratio of PEG to magnesium salt accumulated at or near the hemorrhage where the final ratio of PEG to magnesium
salt is 1 to 6, which indicates a reduction in the size of the hemorrhage, and the injured tissue comprises a spinal cord.

US Pat. No. 9,622,790

ROD EXTENSION FOR EXTENDING FUSION CONSTRUCT

Warsaw Orthopedic, Inc., ...

1. A system comprising:
a fusion implant comprising a pedicle screw and a rod positioned in a receiver of the pedicle screw; and
a spinal fusion extension implant for interconnecting to the fusion implant, the spinal fusion extension implant comprising
a rod having a first portion that is substantially parallel with the rod of the fusion implant, the rod of the spinal fusion
extension comprising an offset beam extending from the first portion and a clamp extending from the offset beam that is coupled
to the rod of the fusion implant, wherein the offset beam extends over the pedicle screw.

US Pat. No. 9,241,754

NERVE AND SOFT TISSUE ABLATION DEVICE

Warsaw Orthopedic, Inc., ...

1. An ablation device comprising: a single probe having at least three prongs branching from the probe such that the at least
three prongs are spaced apart and parallel to each other, the at least three prongs each having an interior surface and an
exterior surface; an internal passage disposed in the interior surface of the at least three prongs; a filament disposed in
the internal passage of the at least three prongs, the filament having an opening configured to release a pressurized material
into the interior surface of the at least three prongs so as to cool the exterior surface of the at least three prongs to
a temperature for ablating nerve and/or soft tissue, wherein one of the at least three prongs is shorter in length than the
other prongs and the one prong shorter in length has a telescopic configuration to increase or decrease in length relative
to the other prongs.

US Pat. No. 9,232,969

DIRECTIONAL CONTROL FOR A MULTI-AXIAL SCREW ASSEMBLY

Warsaw Orthopedic, Inc., ...

1. A multi-axial screw assembly, comprising:
a receiver defining a longitudinal axis and comprising a channel extending transverse to the longitudinal axis for receiving
a rod and an aperture extending parallel to the longitudinal axis between a proximal portion and a distal portion;

a base member comprising an aperture extending parallel to the longitudinal axis through a planar uppermost surface and an
opposite bottom surface of the base member and an opening having a convex cutout extending from the bottom surface of the
base member into a sidewall of the base member, the base member configured to couple to the receiver such that the aperture
of the receiver is generally aligned with the aperture of the base member, the base member being rotatable relative to the
receiver;

a crown received in the receiver such that the crown is rotatable relative to the receiver, the crown being configured to
mate to the base member, the crown having a width that is less than a width of the distal portion and greater than a width
of the proximal portion, the crown having a mating feature configured to couple to the base member such that the crown rotates
the base member when the crown is rotated; and

a bone screw located between the base member and the crown such that a head of the bone screw directly engages a concave bottom
surface of the crown, the bone screw being movable between a first orientation in which a shaft of the bone screw is parallel
to the longitudinal axis and is spaced apart from the cutout and a second orientation in which the shaft is transverse to
the longitudinal axis and at least a portion of the shaft is disposed in the cutout.

US Pat. No. 9,119,672

FLEXIBLE SPINAL STABILIZATION ELEMENT AND SYSTEM

Warsaw Orthopedic, Inc., ...

1. An elongated connecting element for stabilizing a first vertebra with respect to a second vertebra, the elongated connecting
element comprising:
a. a first end member and a second end member substantially aligned along a longitudinal axis;
b. a resilient intermediate element positioned between and abutting the first end member and the second end member, the resilient
member having a length L;

c. a tether extending between the first end member and the second end member and through the resilient intermediate element;
and

d. a sheath positioned between the resilient intermediate element and the tether and at least partially surrounding the tether
along a portion of a length of the tether approximate to the abutments of the resilient intermediate element to the first
and second end members,

wherein a combined length of the first and second end members and the resilient intermediate element is greater than a maximum
length of the tether.

US Pat. No. 9,107,983

OSTEOCONDUCTIVE MATRICES COMPRISING STATINS

Warsaw Orthopedic, Inc., ...

1. An implantable osteoconductive matrix configured to fit at or near a target tissue site, the matrix being malleable and
cohesive and comprising a biodegradable polymer and a therapeutically effective amount of a statin disposed within the interior
of the matrix, the matrix having a load of the statin between about 20 mg and 500 mg, wherein the matrix allows influx of
at least progenitor, and/or bone cells therein, and the matrix comprises ceramic and collagen, the ceramic having a density
of about 0.15 g/cc to about 0.45 g/cc of the matrix and the collagen having a density of about 0.02 g/cc to about 1.0 g/cc
of the matrix and the matrix comprises mineral particles having a porosity of 5% to 25% dispersed therein having an average
particle diameter in the range of 0.1 mm to 2 mm, and the mineral particles overlap each other by at least 75%, and the matrix
comprises polyethylene glycol (PEG), magnesium, an antioxidant and trehalose, and wherein the matrix resist compression by
at least 85% when force is applied to the matrix.

US Pat. No. 9,066,770

SURGICAL DELIVERY INSTRUMENT AND METHOD

Warsaw Orthopedics, Inc.,...

1. A surgical instrument comprising:
a needle extending between a proximal end and a distal end, and defining a longitudinal axis, the needle including an elongated
cavity that defines an opening disposed proximal to the distal end; and

a wire extending between a proximal end and a distal end configured for fixation with tissue, the proximal end of the wire
extending parallel to the longitudinal axis and being movably disposed within the cavity, and the distal end of the wire being
positioned outside of the cavity, the distal end of the wire being wrapped helically about the needle;

the distal end of the wire defines a retainer configured to prevent advancement of the retainer within the tissue, and wherein
the elongated cavity is an open groove defined in an outer surface of the needle.

US Pat. No. 9,051,389

EXPRESSION CONDITIONS AND METHODS OF HUMAN RECOMBINANT GROWTH AND DIFFERENTIATION FACTOR-5 (RHGDF-5)

Warsaw Orthopedic, Inc., ...

1. A cell culture media for growing transformant pGDF-5-Trc-transformed cells, the cell culture media comprising a transformant
pGDF-5-Trc-transformed cells, wherein the pH of the cell culture media is from about 6.8 to about 7, and the GDF-5-Trc-transformed
cells comprise a polynucleotide sequence that encodes the amino acid sequence of SEQ ID NO: 4.

US Pat. No. 10,034,771

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:an implant body extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface and a second vertebral engaging surface;
a tab; and
a plate connectable with the implant body via a coupling member and defining a first opening oriented to implant a fastener with tissue, a second opening configured for disposal of the coupling member and a cavity having the tab positioned therein, the tab comprising a body and an arm that extends from one side of the body, the tab being movable between a first orientation in which the arm overlaps the openings and a second orientation in which the arm is spaced apart from the openings.
US Pat. No. 9,554,920

BONE MATRIX COMPOSITIONS HAVING NANOSCALE TEXTURED SURFACES

Warsaw Orthopedic, Inc., ...

1. A demineralized bone matrix composition comprising lyophilized demineralized bone particles comprising an imparted nanoscale
textured surface comprising collagen nanofibers electrospun onto the demineralized bone particles, wherein the imparted surface
includes at least 60% non-denatured collagen, wherein the composition has less than about 15% moisture content, wherein the
nanoscale textured surface comprises nanostructures each having a length ranging from approximately 40 nm to approximately
600 nm, the nanostructures comprising nanofibers, and the demineralized bone matrix composition further comprising a hydrogel
carrier.

US Pat. No. 9,474,538

SYSTEMS AND METHODS FOR GUIDING ANCHORS FOR FACET FIXATION

Warsaw Orthopedic, Inc., ...

1. An apparatus, comprising:
a retractor including an elongated body extending along a longitudinal axis between a distal end and an opposite proximal
end, said retractor defining a passage between said distal and proximal ends, said retractor further including a window through
said body opening into said passage adjacent to said distal end, said retractor being configured for positioning in a body
of a patient with said distal end adjacent an implantation location in the body of the patient while said proximal end is
located outside the body of the patient;

a guide member extending laterally from said proximal end of said retractor, said guide member including an elongated body
portion extending along an arc, said arc of said body defining a plurality of trajectories relative to said longitudinal axis
of said retractor and each of said plurality of trajectories further intersects said window of said retractor; and

an instrument removably mounted to said guide member, said instrument being movable along said guide member and securable
to said guide member in any selected one of said number of trajectories so that said instrument can be moved along a selected
one of said trajectories through said window, said instrument including a elongated shaft extending through a slot of said
guide member and a clamping mechanism, said elongated shaft being slidably disposed within a passageway of a sleeve member
of said clamping mechanism, said sleeve member being slidably disposed within a passageway of a clamping member of said clamping
mechanism, said clamping member and said sleeve member being configured to move relative to one another engage opposite surfaces
of said guide member to releasably secure said instrument in said selected trajectory through said window.

US Pat. No. 9,433,444

SURGICAL INSTRUMENT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical guide comprising:
a member including an inner surface defining at least one cavity configured for disposal of at least one surgical tool; and
at least one part movable relative to the member and including a lock element engageable with a lock element of a spinal implant,
wherein the locking element of the at least one part includes a pin and the locking element of the spinal implant includes
a slot.

US Pat. No. 9,387,094

OSTEOIMPLANT AND METHOD OF MAKING SAME

Warsaw Orthopedic, Inc., ...

1. An osteoimplant which comprises elongate bone particles selected from the group consisting of fully mineralized elongate
bone particles, fully demineralized elongate bone particles, substantially fully mineralized elongate bone particles, partially
demineralized elongate bone particles, superficially demineralized elongate bone particles, and mixtures thereof wherein mutually
contacting elongate bone particles are entangled with each other;
wherein the entangled bone particles form a coherent aggregate matrix, wherein the coherent aggregate matrix possesses an
open pore, flexible, sponge-like structure configured to absorb fluids while generally retaining predetermined dimensions;
and

wherein the osteoimplant comprises a core composed of the fully demineralized elongate bone particles which have not been
compacted and an outer surface composed of the superficially demineralized elongate bone particles which have not been compacted
surrounding the core.

US Pat. No. 9,326,803

RETAINING MECHANISM

Warsaw Orthopedic, Inc., ...

1. A retaining mechanism comprising:
a stratum comprising a first surface and an opposite second surface, the stratum comprising a hole extending through the first
and second surfaces;

a retaining element comprising a body including a cutout, the retaining element being rotatable between a first position in
which the cutout is aligned with the hole to permit a fastener to be passed through the hole and a second position in which
the body at least partially overlaps the hole; and

a spring element positioned between the stratum and the retaining element, the spring element being configured to engage the
retaining element to help maintain the retaining element in the first position and the second position.

US Pat. No. 9,289,243

METHODS FOR CORRECTING SPINAL DEFORMITIES

Warsaw Orthopedic, Inc., ...

1. A method of treating a patient with a spinal deformity comprising the steps of:
inserting an elongated corrective member into the patient with the corrective member in a first rotational position;
moving the corrective member through a first anchor attached to a first vertebral member;
further inserting the corrective member into the patient and moving the corrective member through a second anchor attached
to a second vertebral member and applying a first corrective force to move the second vertebral member relative to the first
vertebral member;

further inserting the corrective member into the patient and moving the corrective member through a third anchor attached
to a third vertebral member and applying a second corrective force to move the third vertebral member relative to the first
and second vertebral members; and

rotating the corrective member from the first rotational position to a second rotational position after moving the corrective
member through the third anchor to align the second vertebral member with the first vertebral member and align the third vertebral
member with the first and second vertebral members,

wherein the corrective member remains within the first rotational position as the corrective member moves through the anchors.

US Pat. No. 9,265,609

OSTEOGRAFT IMPLANT

Warsaw Orthopedic, Inc., ...

1. An osteograft comprising: a body comprising cortical bone extending along an axis between a first end and a second end
and including an outer surface configured to engage host bone of a patient, the body including an inner surface defining a
passage extending through a top and a bottom surface of the outer surface, the passage comprising two parallel side walls
and two parallel end walls; at least one recess extending transverse to the axis into the outer surface configured for disposal
of an insert; and at least one insert comprising demineralized bone disposed in the at least one recess, and the at least
one insert further comprises demineralized bone matrix powder and demineralized bone matrix fibers coated on an outer surface
of the at least one insert via an adhesive, and the two parallel side walls of the passage each comprise a plurality of recesses
extending perpendicular to the axis.

US Pat. No. 9,205,241

MEDICAL DEVICES AND METHODS COMPRISING AN ADHESIVE MATERIAL

Warsaw Orthopedic, Inc., ...

1. A medical device implantable at or near a target tissue site beneath the skin of a patient, the medical device configured
for implantation beneath the skin and comprising an adhesive sheet and a biodegradable solid or semi-solid drug depot, the
drug depot having at least one surface configured to release a therapeutically effective amount of a drug over a period of
at least one day, the adhesive sheet comprising a plurality of regions, each of the regions comprising at least two slits
substantially parallel to each other and disposed in or on the adhesive sheet, the drug depot being substantially perpendicular
to each of the slits, the drug depot being slidably received by each of the slits in one of the regions to hold the drug depot.

US Pat. No. 9,169,308

METHODS AND COMPOSITIONS OF HUMAN RECOMBINANT GROWTH AND DIFFERENTIATION FACTOR-5 (RHGDF-5) ISOLATED FROM INCLUSION BODIES

Warsaw Orthopedic, Inc., ...

1. A method of isolating recombinant GDF-5 protein from an inclusion body of a prokaryotic cell, the method comprising: disrupting
a prokaryotic host cell transformed with an expression vector having a T5 promoter operatively linked to a polynucleotide
sequence that encodes a GDF-5 protein such that the prokaryotic host cell releases the inclusion body of GDF-5 protein and
recovering the GDF-5 protein from the inclusion body by contacting the GDF-5 protein with a substrate, wherein the GDF-5 protein
is a recombinant human GDF-5 (rhGDF-5) protein comprising the amino acid sequence of SEQ ID NO: 4.
US Pat. No. 9,125,902

METHODS FOR TREATING AN INTERVERTEBRAL DISC USING LOCAL ANALGESICS

Warsaw Orthopedic, Inc., ...

1. A method of treating pain from an intervertebral disc in a patient in need of such treatment, the method comprising:
administering an immediate release analgesic at or near the intervertebral disc;
administering a bulking agent to at least partially bulk a tissue or fill a biological cavity after administering the immediate
release analgesic, the bulking agent remaining as a permanent or non-degrading implant, the bulking agent comprising a macromer
having a polyvinylalcohol backbone comprising units with a 1,2-diol structure and at least two pendent chains bearing crosslinkable
groups, the bulking agent further comprising an amphiphilic comonomer, wherein the implant has a yield load between 1000 to
6000 Newtons to facilitate replacement of a nucleus pulpous; and

administering a sustained release analgesic within the intervertebral disc after administering the bulking agent, wherein
the sustained release analgesic releases the analgesic over a period of at least one day.

US Pat. No. 9,072,550

SPINAL FIXATION SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal fixation system, comprising:
a first plate configured to be positioned to span between spinal processes of two adjacent vertebrae;
a post having one end fixedly attached to the first plate and a distal second end;
a second plate positioned opposite said first plate and configured to receive the distal end of said post, said second plate
being capable of at least axial translation along said post,

a locking mechanism configured to restrict translation of the second plate along the post, the locking mechanism comprising:
a tapered collet disposed around the post; and a tapered inboard surface of the second plate, wherein applying force to the
tapered collet causes an interference fit between the second plate and the post and restricts axial translation of the second
plate along said post.

US Pat. No. 9,844,397

SPINAL CORRECTION SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal construct comprising:
a first member configured for attachment to a first portion of vertebral tissue that defines a longitudinal axis; and
a second member that is detached from the first member and configured for attachment to a second portion of the vertebral
tissue such that the second portion is axially movable relative to the second member and sagittal movement of the second member
relative to the second portion is resisted and/or prevented.

US Pat. No. 9,585,764

BONE IMPLANT DEVICE

Warsaw Orthopedic, Inc., ...

1. An osteoimplant device comprising: a body, which comprises a nondemineralized cortical bone, the nondemineralized cortical
bone body includes a disc and at least one region comprising an enzymatically modified and ionically charged demineralized
bone comprising a regular or irregular shape comprising an annular periphery, a substantially crescent shape periphery, a
substantially semicircular shape periphery, a substantially O shape periphery or combinations thereof, wherein the implant
device is formable into a shape and size configured for implantation at a surgical site, and wherein the at least one region
of demineralized bone comprises demineralized bone fibers and demineralized bone chips in a ratio of from about 25:75 to about
75:25 fibers to chips and at a depth of from about 50 microns to about 5000 microns, and the osteoimplant comprises a compressive
modulus of from about 2,000 MPa to 3,800 MPa and exhibits resiliency and flexibility of from about 10 degree to about 45 degree
angles.

US Pat. No. 9,585,650

SURGICAL SPACER INSTRUMENT AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical instrument comprising:
a first member defining a longitudinal axis;
a second member being connected with a pivot; and
a third member defining a first axis disposed at an angular orientation relative to the longitudinal axis and being connected
with the pivot,

wherein the second member is translatable relative to the first member to rotate the pivot to move the third member between
a first orientation and a second orientation to space vertebral tissue,

wherein the third member includes a shaft connected with the pivot, and
wherein rotation of the pivot translates the shaft to move the third member between a first orientation and a second orientation
to space vertebral tissue.

US Pat. No. 9,433,442

SPINAL CORRECTION SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal construct comprising:
at least one tether extending between a first end connectable with a first fastener connected with spinal tissue and a second
end connectable with a second fastener connected with spinal tissue, the at least one tether having a tension between the
fasteners; and

a ratchet engageable with the at least one tether to adjust the tension, the ratchet includes a rotatable reel configured
for rotation in two directions to adjust the tension, the rotatable reel being axially movable between a first configuration
in which the reel is rotatable relative to the ratchet and a second configuration in which rotation of the reel is resisted.

US Pat. No. 9,414,859

SURGICAL ROD MEASURING SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A system for measuring an implant, comprising:
a processor;
a probe in communication with the processor and configured to trace along a surface of the implant;
a tracking system in communication with the processor and the probe for generating first data representing at least one of
linear and rotational movement of the probe during a first trace along the surface of the implant;

wherein the processor is configured to receive the first data and generate a first graphical representation of the implant
based on the first data; and

a display in communication with said processor for displaying the first graphical representation of the implant based on the
first data,

wherein the processor is configured to calculate an angular offset between at least two portions of the implant based on the
first data and display the angular offset.

US Pat. No. 9,364,568

METHODS TO DIAGNOSE DEGENERATIVE DISC DISEASE

Warsaw Orthopedic, Inc., ...

1. A method for diagnosing a pain generator or a suspected pain generator in a patient suffering from neck or back pain, the
method comprising administering a diagnostic agent comprising a tracer that specifically binds to a pain marker at a location
inside of or adjacent to an intervertebral disc in the patient suffering from neck or back pain thereby labeling the pain
marker with the diagnostic agent; allowing the labeled pain marker to bind the pain generator or suspected pain generator;
and comparing the amount of labeled pain marker in a location inside of or adjacent to the intervertebral disc to a normal
range of the labeled pain marker inside of or adjacent to an intervertebral disc via imaging, wherein the amount of the labeled
pain marker outside of the normal range indicates the location of and diagnoses the pain generator or suspected pain generator,
and the labeled pain marker bound to the pain generator or suspected pain generator can be 30% or higher than the normal range
of labeled pain marker or labeled pain generator present, wherein the tracer has a binding affinity of at least 108M?1, and the pain marker comprises vascular endothelial growth factor, and the diagnostic agent is disposed in a matrix to retain
the diagnostic agent at the location inside of or adjacent to the intervertebral disc in the patient, the diagnostic agent
being in an amount of at least 35 wt. % of the matrix in microfiber particle form.

US Pat. No. 9,333,012

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant system comprising:
a first member extending along a longitudinal axis between a proximal portion and a distal portion, the proximal portion including
a pair of walls, inner surfaces of the walls defining an implant cavity, the distal portion including a tissue penetrating
portion, the walls each including first and second axial end surfaces that each extend from the inner surface of one of the
walls to an opposite outer surface of one of the walls, the outer surfaces each including a locking cavity;

a second member comprising a body and a pair of extensions that extend from the body, the extensions being spaced apart from
one another by a first cavity, the extensions each comprising opposing faces that engage the axial end surfaces of one of
the walls to couple the second member to the first member; and

a third member disposed in the first cavity, and including an inner surface having a protrusion extending therefrom,
wherein the third member is configured for axial translation relative to the second member between a first orientation in
which the protrusion is disposed in one of the locking cavities and a second orientation in which the protrusion is spaced
apart from the locking cavities.

US Pat. No. 9,308,292

FORMABLE AND SETTABLE POLYMER BONE COMPOSITE AND METHODS OF PRODUCTION THEREOF

Warsaw Orthopedic, Inc., ...

1. A method of preparing an osteoimplant, comprising:
forming a composite comprising bone-derived particles and a polymer into a predetermined shape, the composite being manipulated
into the predetermined shape at a temperature greater than about 40° C., the polymer comprising starch poly(caprolactone),
poly(caprolactone), poly(l-lactide), poly(dl-lactide-co-glycolide), poly(l-lactide-co-dl-lactide), enantiomers thereof, copolymers
thereof, and/or mixtures thereof, wherein the bone-derived particles are about 50% to about 75% by weight of the composite
and the bone-derived particles have a size between about 50 ?m and about 1 mm; and

causing the polymer to set.

US Pat. No. 9,277,939

SPINAL CORRECTION SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant system comprising:
at least one longitudinal element extending between a first portion and a second portion;
at least one fixation element extending a longitudinal axis between a first end and a second end configured for penetrating
tissue; and

a coupling member configured for disposal about the at least one longitudinal element, the coupling member including a first
part and a second part being movable relative to the first part between a first orientation and a second orientation such
that an inner surface of the parts are fixed with the at least one longitudinal element, the parts including an outer surface
such that in the second orientation the coupling member is configured for a snap fit engagement with the at least one fixation
element such that the coupling member is prevented from translating along the longitudinal axis.

US Pat. No. 9,265,830

IMPLANTABLE COMPOSITIONS AND METHODS FOR PREPARING THE SAME

Warsaw Orthopedic, Inc., ...

13. An implantable composition comprising:
a delivered material, and
a carrier comprising:
a gel base comprising alginate and dextran;
a hydrating agent; and
citric acid anhydrous;
wherein a water content of the implantable composition is about 5%, about 3%, or about 1% by weight of the composition.

US Pat. No. 9,204,904

VARIABLE ANGLE ADAPTIVE PLATE

Warsaw Orthopedic, Inc., ...

1. An apparatus, comprising:
a plate having a first end, a second end, an upper surface, an opposite lower surface, a perimeter, a first aperture extending
through said plate proximate said first end, and a second aperture extending through said plate proximate said second end;

an attachment member having a top surface, an opposite bottom surface and spaced apart first and second holes extending therethrough
from said top surface to said bottom surface, said attachment member adapted for anchoring to a vertebra and to connect to
said plate proximate one of said first and second apertures; and

first and second screws each having a shaft and a head portion at one end of said shaft for anchoring said attachment member
to bone, at least a portion of said head portion of said first screw being positioned in said first hole and at least a portion
of said head portion of said second screw being positioned in said second hole;

wherein at least a portion of said perimeter of said plate covers at least a portion of each of said head portions with said
lower surface of said plate positioned in contact with said top surface of said attachment member and with said head portions
at least partially positioned between said plate and said attachment member, and

wherein said attachment member comprises a first prong extending from said bottom base positioned at a first corner of said
attachment member and a second prong extending from said bottom base positioned at an opposite second corner of said attachment
member, said first and second prongs each including a pointed distal fixation end.

US Pat. No. 9,179,948

INSTRUMENTS AND METHODS FOR STABILIZATION OF BONY STRUCTURES

Warsaw Orthopedic, Inc., ...

1. A minimally invasive surgical system, comprising:
at least a pair of anchors for engaging a bony structure of a patient, each anchor having a passageway;
at least a first and a second anchor extension, each extension having a distal end mounted to at least one anchor;
a brace positionable within the patient, the brace having a longitudinal axis; and
an inserter in contact with the brace, the inserter operable to percutaneously position the brace so that the longitudinal
axis of the brace is inserted into the passageways of the anchors.

US Pat. No. 9,180,020

SYSTEM FOR STABILIZING A PORTION OF THE SPINE

Warsaw Orthopedic, Inc., ...

1. A spinal plate, comprising:
an elongate body including a length extending along a central longitudinal axis, the length of the elongate body being adapted
to span a space between adjacent vertebrae, the body including a first connection portion attachable to a first one of the
adjacent vertebrae and a second connection portion attachable to a second one of the adjacent vertebrae, and an intermediate
portion extending between the first and second connection portions, the first and second connection portions each including
spaced apart first and second openings and a countersunk portion positioned between the first and second openings, the intermediate
portion including a visualization opening extending therethrough for visualizing the space when the plate is attached to the
adjacent vertebrae, the visualization opening including at least one convexly curved side wall, the visualization opening
and the countersunk portion being located along the central longitudinal axis;

a plurality of washers, one of the washers being disposed in each of the countersunk portions; and
a plurality of bone screws, a respective one of the bone screws extending through a respective one of the washers such that
a head of the bone screw removably engages an inner surface of the washer.

US Pat. No. 9,144,503

EXPANDABLE SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:
a first member defining a longitudinal axis and including a wall that defines an axial cavity and at least one lateral opening
configured for disposal of an instrument;

a second member configured for disposal with the axial cavity and including a wall having an axial surface disposed along
a thickness thereof, the axial surface defining at least a portion of an axial opening and including a plurality of gear teeth
disposed therealong; and

a third member comprising a circumferential ring configuration, the third member being rotatable relative to the inner surface
and engageable with the second member,

wherein the instrument is directly engageable with the teeth to axially translate the second member relative to the first
member, and the first member comprises a lock selectively engageable with the third member to prevent the axial translation,
the lock being prevented from translating axially relative to the first member.

US Pat. No. 9,101,606

BONE DELIVERY SYSTEM HAVING A THERAPEUTIC AGENT

Warsaw Orthopedic, Inc., ...

1. A delivery system comprising: a covering configured for implantation into a bone defect site and comprising one or more
polymers, the covering being porous and comprising at least one compartment, and a score line extending partially across the
width of the covering; a demineralized bone matrix material comprising fully demineralized bone matrix fibers and surface
demineralized bone chips in a ratio of about 25:75 to about 75:25, the demineralized bone matrix material disposed within
the at least one compartment, wherein the covering retains the demineralized bone matrix material for placement at the bone
defect site and facilitates transfer of cells into and out of the covering and the covering comprises a therapeutic agent
disposed within the at least one compartment or on a surface of the covering, wherein the covering comprises a modulus of
elasticity of about 1×102 to about 6×105 dynes/cm2 before placement at the bone defect site, and a modulus of elasticity of 1×102 to about 6×105 dynes/cm2 after placement at the bone defect site, and the covering comprises edges comprising a polymer that is different and more
hydrophilic than the at least one or more polymers of the rest of the covering.

US Pat. No. 9,095,445

VERTEBRAL INTERBODY SPACER

Warsaw Orthopedic, Inc., ...

1. An interbody spacer for positioning between vertebrae, comprising:
an elongated central body portion extending along a longitudinal axis between a leading end portion and a trailing end opposite
said leading end portion, said body portion including a pair of opposite lateral side walls extending transverse to said longitudinal
axis from said leading end portion to said trailing end to define a length of said body portion, said body portion defining
a mid-length plane that is orthogonal to said longitudinal axis, said body portion comprising a receptacle extending along
said longitudinal axis through said trailing end, said receptacle comprising a blind end;

an upper bearing surface extending along said longitudinal axis that is curved between said leading end portion and said trailing
end, said upper bearing surface for placement against an endplate of a superior vertebra;

an opposite lower bearing surface extending along said longitudinal axis that is curved between said leading end portion and
said trailing end, said lower bearing surface for placement against an endplate of an inferior vertebra, said opposite upper
and lower bearing surfaces defining a maximum height between said bearing surfaces at a first location that is offset from
said mid-length plane toward said leading end portion, wherein:

said lateral side walls each define a continuous convexly curved profile extending from said leading end portion to said trailing
end, said continuous convexly curved profiles defining a maximum width of said body portion between said lateral side walls
at a second location that is offset from said mid-length plane toward said leading end portion; and

said upper and lower bearing surfaces each including a series of projections extending outwardly therefrom, said projections
having a uniform cross sectional shape, said projections being spaced longitudinally from one another from said leading end
portion to said trailing end, one of said projections adjacent said leading end portion and one of said projections adjacent
said trailing end extending continuously from one of said lateral side walls to the other of said lateral side walls.

US Pat. No. 9,060,817

SYSTEMS AND METHODS FOR MINIMALLY INVASIVE SURGICAL PROCEDURES FO SYSTEMS

Warsaw Orthopedic, Inc., ...

1. An anchor extender, comprising:
an elongated body extending between a proximal end portion and a distal end portion;
a first pair of engaging members coupled with said elongated body adjacent said distal end portion such that said first pair
of engaging members are pivotable relative to one another, said first pair of engaging members being movable between a first
configuration for receiving and releasing a first portion of a bone anchor and a second configuration for engaging said first
portion of said bone anchor;

a second pair of engaging members coupled with said elongated body adjacent said distal end portion and opposite of said first
pair of engaging members such that said second pair of engaging members are pivotable relative to one another, said second
pair of engaging members being movable between a first configuration for receiving and releasing a second portion of said
bone anchor and a second configuration for engaging said second portion of said bone anchor; and

a locking mechanism axially displaceable relative to said elongated body, wherein said locking mechanism is configured to
lock said first and second pairs of engaging members in said second configuration.

US Pat. No. 9,050,274

COMPOSITIONS AND METHODS FOR TREATING AN INTERVERTEBRAL DISC USING BULKING AGENTS OR SEALING AGENTS

Warsaw Orthopedic, Inc., ...

1. A composition for treating an intervertebral disc in a patient in need of such treatment, the composition comprising a
bulking agent or sealing agent comprising polyvinylalcohol in the form of fibers, the bulking or sealing agent comprises pendent
chains comprising crosslinkable groups of N-acrylamidoacetaldehyde dimethyl acetal in an amount of 6 to 21 crosslinkers per
polyvinylalcohol, the bulking agent or sealing agent adapted to be administered at or within the intervertebral disc to treat
leakage and/or augment the intervertebral disc, the bulking or sealing agent having a plurality of drug depots that are uniformly
distributed within the bulking or sealing agent, the drug depots each comprising an effective amount of a therapeutic agent
disposed therein, wherein the drug depots each comprise a biopolymer comprising polylactide (PLA) and polyglycolide (PGA),
the biopolymer comprising at least 80% PLA, the remainder of the biopolymer being PGA, wherein the biopolymer comprises at
least 50 wt % of the composition, and the drug depots are capable of releasing an effective amount of the therapeutic agent
over a period of 3 to 45 days.

US Pat. No. 10,070,971

SURGICAL INSTRUMENT AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical system comprising:a spinal implant;
a member including a body defining a longitudinal axis and a channel;
an inner shaft disposed within the channel, the inner shaft being translatable relative to the body, the inner shaft being connected with the spinal implant;
positioned in the channel, the rod being configured to translate relative to the body along the longitudinal axis, the spinal implant being connected with the rod;
a first image guide connected with the body such that the first image guide is rotatable relative to the body about the longitudinal axis, the first image guide being oriented relative to a sensor to communicate a signal representative of a three-dimensional position of the body;
a second image guide connected with the rod such that the second image guide is movable along the longitudinal axis, the second image guide being oriented relative to a sensor to communicate a signal representative of a position of the spinal implant; and
a grip connected with the body by a pin such that the grip is pivotable relative to the body about the pin, the grip being movable between a first orientation in which the inner shaft is fixed relative to the body and a second orientation in which the inner shaft is configured to translate relative to the body.
US Pat. No. 10,029,031

BONE VOID FILLER HAVING SUSTAINED THERAPEUTIC AGENT RELEASE

Warsaw Orthopedic, Inc., ...

1. A bone void filler material for sustained release of a therapeutic agent, the bone void filler material comprising a biodegradable matrix comprising collagen having ceramic particles and cement beads, the cement beads being settable and having a setting time from about 20 seconds to about 30 minutes, the cement beads comprising from about 1 to about 30% by weight of the matrix and loaded with from about 1 to about 35% by weight of a therapeutic agent to cause a burst release of the therapeutic agent, the cement beads having a size of about 1 micron to about 200 microns, the ceramic particles having a particle size of 1 micron to 200 microns and also being loaded with the therapeutic agent, the ceramic particles are coated with cross-linked collagen, the coating of the cross-linked collagen being from 1 micron to 5 microns thick to cause sustained release of the therapeutic agent, wherein the biodegradable matrix is in sponge form and the ceramic particles comprise 1% to 5% by weight of the biodegradable matrix, wherein the ceramic particles have a burst release surface that releases about 10% to about 30% of the therapeutic agent over 24 or 48 hours and the cement beads have a burst release surface that releases about 10% to about 50% of the therapeutic agent over 24 or 48 hours, wherein the bone void filler material is osteoinductive and osteoconductive and contains demineralized bone matrix (DBM) particles.

US Pat. No. 9,622,811

SURGICAL INSTRUMENT AND METHOD

Warsaw Orthopedic, Inc., ...

1. An electro-surgical instrument comprising:
a first member extending between a first end having a first electrode and a second end having spaced apart arms;
a second member extending along a longitudinal axis between a first end having a second return electrode and a second end
having a slot, the first ends defining a tissue cavity;

a lever comprising spaced apart extensions, outer surfaces of the extensions engaging inner surfaces of the arms and an outer
surface of the second end of the second member engaging inner surfaces of the extensions;

a first pin extending through the arms, the extensions and the slot; and
a second pin extending through the extensions and the second end of the second member, wherein pivoting the lever relative
to the second member about the second pin translates the first in within the slot to move the first member relative to the
second member along the longitudinal axis to selectively adjust a length of the cavity.

US Pat. No. 9,585,872

CLONIDINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER

Warsaw Orthopedic, Inc., ...

1. An implantable drug depot for reducing or treating pain in a patient in need of such treatment, the implantable drug depot
comprising clonidine in an amount from about 1 wt. % to about 20 wt. % of the drug depot, and at least one biodegradable polymer,
wherein the drug depot is capable of releasing clonidine over a period of at least three days, and the at least one biodegradable
polymer is poly(D,L-lactide) having an inherent viscosity of from about 0.45 dL/g to about 0.55 dL/g, and the clonidine is
in the form of clonidine hydrochloride.
US Pat. No. 9,492,461

METHODS AND COMPOSITIONS FOR TREATING INTERVERTEBRAL DISC HERNIATIONS

Warsaw Orthopedic, Inc., ...

1. A method of treating intervertebral disc herniation in a patient in need of such treatment, the method comprising administering
one or more biodegradable drug depots comprising a therapeutically effective amount of a glucocorticoid through a tear in
an annulus fibrosis and into a nucleus pulposus of the intervertebral disc herniation, wherein a portion of the nucleus pulposus
is leaving the tear, and the one or more biodegradable drug depots does not contain fibrin and is capable of releasing an
effective amount of the glucocorticoid over a period of at least 3 days to 6 months, the one or more drug depots comprising
a polymer having an inherent viscosity of 0.45 dL/g to 0.55 dL/g, the polymer comprising poly(DL-lactide) having ester end
groups and the glucocorticoid is fluocinolone in an amount of about 0.5% to 20% by weight based on the total weight of the
drug depot, and the fluocinolone has a particle size from about 10 ?m to 100 ?m, and the one or more biodegradable drug depots
comprises mPEG.

US Pat. No. 9,399,086

IMPLANTABLE MEDICAL DEVICES

Warsaw Orthopedic, Inc, ...

1. An implantable medical device, comprising:
a body including an external surface defining an outer profile of said device, said body further including:
a porous matrix having a compressive strength of about 10 MPa and including a series of interconnected macropores defined
by a plurality of interconnected struts, said struts each including a hollow interior;

a filler material substantially filling at least a portion of said series of interconnected macropores, said filler material
comprising a polymeric material selected from the group consisting of polyetheretherketone (PEEK), carbon-reinforced PEEK,
and polyetherketoneketone (PEKK); and

a plurality of openings extending through at least a portion of said external surface and communicating with said hollow interior
of at least a portion of said plurality of interconnected struts.

US Pat. No. 9,381,095

IMPLANT FOR TRANSFORAMINAL INTRACORPOREAL FUSION

Warsaw Orthopedic, Inc., ...

1. An implant for the transforaminal interbody fusion of lumbar vertebral column segments, comprising:
a main body including a top surface configured for disposal adjacent a first vertebral surface and a bottom surface situated
opposite the top surface configured for disposal adjacent a second vertebral surface, the main body having a sickle shape
and further including an inner side wall and an outer side wall situated opposite the inner side wall, and a first end portion
having a beak-like tapering and a second end portion situated opposite the first end portion, the second end portion having
a throughbore formed therein and oriented transversely in the main body in a direction between the top surface and the bottom
surface and the main body having at least one filling hole adjacent to and separate from the throughbore, the throughbore
comprising a bolt having a side wall and an insertion opening formed in the side wall extending through the bolt.

US Pat. No. 9,333,080

INJECTABLE AND MOLDABLE BONE SUBSTITUTE MATERIALS

Warsaw Orthopedic, Inc., ...

1. A composite osteoimplant comprising:
a plurality of particles comprising an inorganic material, a bone substitute material, a bone-derived material, or any combination
thereof; and

a polymer with which the plurality of particles has been combined;
wherein the composite is moldable or flowable; and
wherein the composite becomes set upon exposure to suitable conditions for setting the composite, the suitable conditions
comprising cooling.

US Pat. No. 9,289,250

EXTENDER COLLAR SYSTEM

Warsaw Orthopedic, Inc., ...

1. A collar configured for connection to a proximal end of an extender comprising:
a body extending along a longitudinal axis between opposite proximal and distal end surfaces, the body including an outer
surface and an inner surface configured to define a first cavity, a second cavity and an intermediate cavity disposed therebetween,
the inner surface including at least one wall projecting therefrom and being disposed about the intermediate cavity, wherein
the first and second cavities receive the proximal end of the extender to prevent splaying and the intermediate cavity includes
a passageway configured for disposal of a surgical instrument,

wherein the body further comprises a stop member positioned at a proximal end of at least one of the first and second cavities
such that the stop member forms a portion of the proximal end surface, the stop member being permanently fixed relative to
the inner surface and configured to block at least a portion of a respective one of the first and second cavities to prevent
the extender from protruding past the proximal end of at least one of the first and second cavities.

US Pat. No. 9,211,198

METHOD FOR USING A GUARD FOR CREATING A SOCKET POSTERIORLY IN THE LUMBAR SPINE

WARSAW ORTHOPEDIC, INC., ...

11. A method for inserting a bone implant into a posterior aspect of the human spine, comprising:
placing a guard against the posterior aspect of the spine, the guard having a passage therethrough;
forming a socket through a portion of a facet joint using a bone removal device inserted through the passage of the guard,
wherein forming the socket includes compacting portions of bone forming the socket to increase the density of the bone forming
the socket, the socket having a maximum height; and

inserting a bone implant having a circular cross section into the socket, the bone implant having a leading end, a trailing
end, a mid-longitudinal axis through the ends, and a height transverse to the mid-longitudinal axis, the height of the bone
implant being greater than the maximum height of the socket.

US Pat. No. 9,173,689

RETAINING MECHANISM

Warsaw Orthopedic, Inc., ...

1. A retaining mechanism for use in affixing a stratum to bone, the mechanism comprising:
a stratum comprising a first surface, a second surface, and a hole extending between the first surface and the second surface,
the hole having a central longitudinal axis that extends substantially perpendicular to the first surface and the second surface,
wherein the second surface is configured to engage at least a portion of the bone;

a retaining element comprising:
a first position that permits a fastener to be passed through the hole, and
a second position that at least partially overlaps the hole, the retaining element being configured to rotate from the first
position to the second position; and

a spring element configured to engage the stratum and the retaining element such that the spring element maintains the retaining
element in its second position so as to prevent inadvertent backing out of the fastener after the fastener has been fully
inserted into the hole.

US Pat. No. 9,138,209

ANNULUS REPAIR SYSTEM

Warsaw Orthopedic, Inc., ...

1. An annulus repair system comprising:
a tubular blocking component extending between a first end and a second end, the blocking component having an interior facing
surface defining a continuous passageway extending between the first and second ends and an exterior facing surface that covers
a hole in an annulus from within a disc space, said exterior facing surface configured to contact an interior surface of the
annulus;

a stabilizing component having an interior facing surface and an exterior facing surface that helps stabilize the blocking
component from within a disc space, the stabilizing component being configured for disposal within the passageway such that
said exterior facing surface of said stabilizing component contacts the interior facing surface of the blocking component;
and

a suturing material that connects the two components together.

US Pat. No. 9,101,405

VERTEBRAL IMPLANT AND CONNECTOR

Warsaw Orthopedic, Inc., ...

1. An implant system comprising:
a fastener including a proximal portion and a distal portion, the proximal portion including an inner surface that defines
a first cavity that defines a first axis, the distal portion being configured for penetrating tissue and defining a longitudinal
axis disposed transverse to the first axis;

a connector extending between a first end and a second end configured for disposal in the first cavity, the first end of the
connector including a side surface defined between a lower surface and an upper surface of the first end of the connector;
and

a receiver attachable to the first end of the connector and including a laterally extending arcuate arm, the side surface
and the arcuate arm defining an implant cavity defining a second axis, the implant cavity being configured for disposal of
an implant such that the implant engages an inner surface of the arcuate arm and the side surface, the implant cavity being
rotatable about a third axis disposed transverse to the second axis such that an implant disposed in the implant cavity and
lateral to the first end of the connector is rotatable in a first plane relative to the first end of the connector in a configuration
for selective fixation with the first end of the connector,

wherein the first end of the connector includes a first disk being disposed in a co-axial orientation with the second end
of the connector and the implant, the first disk having a first splined surface, and the receiver including a second disk
having a second splined surface that mates with the first splined surface.

US Pat. No. 9,839,722

BONE VOID FILLER HAVING CALCIUM COATINGS

Warsaw Orthopedic, Inc., ...

1. A bone void filler material for sustained release of a therapeutic agent, the bone void filler material comprising a biodegradable
matrix having ceramic particles disposed within the matrix, the ceramic particles being adsorbed with the therapeutic agent
and coated with a settable ceramic cement to cause sustained release of the therapeutic agent, and the therapeutic agent comprises
an antibiotic, the ceramic particles are loaded with the therapeutic agent in an amount of about 20% to about 80% based on
a total weight of the ceramic particles, wherein the biodegradable matrix has pores ranging from about 1 micron to about 1,000
microns in size, the ceramic particles have a size ranging from about 1 micron to about 800 microns, and the coating thickness
of the settable ceramic cement on the ceramic particles is from about 10 to about 40 microns, and the ceramic particles have
a burst release surface that releases about 10% to about 30% of the therapeutic agent over 24 or 48 hours.

US Pat. No. 9,655,738

EXPANDABLE SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:
a first member defining a longitudinal axis and including a wall that defines a first axial cavity and a lateral opening configured
for disposal of an instrument; and

a second member configured for disposal with the first axial cavity and including a wall that defines a second axial cavity,
the wall of the second member having a first axial surface and a second axial surface that faces the first axial surface,
at least one of the axial surfaces including a plurality of mating elements disposed therealong, wherein the first member
is spaced apart from the first and second axial surfaces and the instrument is engageable with the mating elements to axially
translate the second member relative to the first member.

US Pat. No. 9,622,788

IMPLANT ASSEMBLY WITH A RIGID INTERFACE

Warsaw Orthopedic, Inc., ...

1. An implant assembly comprising:
a receiver extending along a longitudinal axis between a proximal end and a distal end, the proximal end configured for receiving
an elongated member, the distal end comprising a threaded inner surface defining a cylindrical shaped opening that receives
a correspondingly shaped threaded head of a bone anchor such that the threads on the inner surface engage the threads on the
head, the bone anchor having a tip opposite the head, the tip configured to engage bone, a connector member that contacts
at least the distal end of the receiver and at least the head of the bone anchor to provide a rigid interface between the
receiver and the head of the bone anchor such that the receiver is fixed relative to the bone anchor, the assembly further
comprising a saddle, separate from the connector member, inserted into the receiver such that the saddle can pivot therein.

US Pat. No. 9,504,480

METHODS AND INSTRUMENTS FOR USE IN VERTEBRAL TREATMENT

Warsaw Orthopedic, Inc., ...

18. An instrument configured to remove tissue from a facet joint comprising:
a body for use in controlling the placement of the instrument;
a first cutting face coupled to the body and configured to be oriented toward a first articular process of the facet joint,
the first cutting face comprising a plurality of rasp teeth;

a second cutting face coupled to the body and positioned opposite the first cutting face, the second cutting face extending
parallel to the first cutting face and configured to be oriented toward a second articular process of the facet joint when
the first cutting face is oriented toward the first articular process, the second cutting face comprising a plurality of rasp
teeth;

opposite first and second lateral surfaces extending between the first and second cutting faces, the first and second lateral
surfaces being smooth and free of any protrusions;

a stop that extends from the first cutting face such that the stop extends perpendicular relative to the first cutting face,
the stop being configured to restrict advancement of the instrument into the facet joint at least in part by contacting a
portion of a vertebra, the stop being smooth and free of any protrusions, a longitudinal axis defined by the stop intersecting
the second cutting face; and

a self-distracting leading end positioned between the first and second cutting faces and between the first and second lateral
surfaces, the self-distracting leading end being configured to separate vertebrae from each other when the leading end is
introduced into the facet joint, the self-distracting leading end being smooth and free of any protrusions, the self-distracting
leading end having a curved incline that is more curved near the first cutting face than the second cutting face.

US Pat. No. 9,492,375

FOAM CARRIER FOR BONE GRAFTING

Warsaw Orthopedic, Inc., ...

1. An osteogenic composition for implantation at or near a target tissue site, the osteogenic composition having no demineralized
bone particles and comprising:
polymeric beads comprising immediate release beads and sustained release beads for delivering an isolated osteoinductive agent
comprising a sterile growth factor at or near the target tissue site, the polymeric beads being biodegradable and synthetic;
the polymeric beads comprising the growth factor, mPEG as an excipient in an amount of from about 0.05 wt. % to about 85 wt.
%, a viscosity enhancing agent, degradation/release modifiers and sterile preservative free material; and

a porous foam comprising layers for confining the polymeric beads at or near the target tissue site, wherein the immediate
release beads and sustained release beads are disposed throughout the layers of the foam, the porous foam being biodegradable
and containing a plurality of pores having a size between about 100 micrometers and about 350 micrometers at their widest
points; and

wherein the growth factor comprises bone morphogenic protein;
wherein the amount of bone morphogenic protein is from 1 to 2 mg per cubic centimeter of said osteogenic composition;
wherein the foam has a density of between about 0.2 g/cm3 to about 1.1 g/cm3; and

wherein the porous foam comprises seeded hone cells or tissue.

US Pat. No. 9,427,325

INTERBODY IMPLANT AND METHOD

Warsaw Orthopedic, Inc., ...

1. An interbody endcap comprising:
a wall having a first surface connected to an interbody implant and a second surface including an arcuate portion configured
for engagement with a vertebral endplate surface when the interbody endcap and a second endcap that is coupled to the interbody
implant are each in contact with vertebral endplate surfaces, the wall having an opening that extends through the first and
second surfaces and a first mating part positioned within the opening that is configured to engage a second mating part of
the interbody implant,

wherein the second surface extends outwardly from the interbody implant to at least adjacent a perimeter of the vertebral
endplate surface.

US Pat. No. 9,364,270

SURGICAL TOOL

Warsaw Orthopedic, Inc., ...

1. A battery pack for a surgical tool comprising:
a housing with an elongated body and opposing first and second ends, the housing including an elongated shape with a longitudinal
axis that extends through the first and second ends, the housing including an interior space between the body and the first
and second ends;

a passage positioned within the interior space of the housing and through the first and second ends, the passage including
an exterior wall that segregates the passage from the interior space and an open interior, the passage is coaxial with the
longitudinal axis of the housing; and

at least one power cell positioned within the interior space of the housing.

US Pat. No. 9,301,849

ENDPLATE PUNCH TEMPLATE AND METHOD OF USE

Warsaw Orthopedic, Inc., ...

1. An instrument for penetrating an endplate surface of a vertebra comprising:
a first plate having an endplate engaging surface comprising a plurality of extensions projecting therefrom to form a first
extension template, the first extension template including a centrally disposed extension and at least one extension radially
disposed about the centrally disposed extension wherein the first extension template is configured to penetrate a first endplate
surface of a vertebra when advanced into the first endplate surface of the vertebra; and

a second plate having an endplate engaging surface comprising a plurality of extensions projecting therefrom to form a second
extension template, the second extension template including a centrally disposed extension and at least one extension radially
disposed about the centrally disposed extension wherein the second extension template is configured to penetrate a second
endplate surface of the vertebra when advanced into the second endplate surface of the vertebra,

wherein at least one of the plurality of extensions projecting from the first and second extension endplates is rotatable
relative to the first and second plates in communication with at least one of the plurality of extensions, wherein the rotation
of the at least one extension relative to the first and second plates is about a longitudinal axis of the extension which
passes along a length of the extension.

US Pat. No. 9,271,844

EXPANDABLE SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

13. A spinal implant comprising:
an outer body including a wall having an inner surface that defines a chamber;
an inner body extending between a first end comprising spikes and defining an opening and a second end, the inner body defining
a longitudinal axis, the inner body including a wall defining an axial channel;

at least one cylindrical insert comprising demineralized cancellous bone particles and demineralized cortical bone particles,
the at least one insert being selectively configured and dimensioned for disposal within the axial channel and expansion upon
exposure to liquid in vivo into the chamber;

wherein the second end is disposable within the chamber such that the inner body is axially translatable relative to the outer
body between a first configuration and a second, expanded configuration such that at least a portion of the at least one insert
is disposed within the chamber and the chamber includes a substantially void portion; and

bone graft having a selective configuration and dimension for disposal within the substantially void portion.

US Pat. No. 9,271,846

EXPANDING INTERBODY IMPLANT AND ARTICULATING INSERTER AND METHOD

Warsaw Orthopedic, Inc., ...

1. A device to space vertebral members comprising:
a first member having an interior side with a first angled section and an exterior side with a first contact surface;
a second member having a second interior side and a second exterior contact surface;
a third member positioned between the first member and the second member, the third member having a first side with a second
angled section positioned towards the first angled section, and a second side positioned towards the interior surface of the
second member;

the device positionable between a first orientation with the first angled section engaged with the second angled section and
having a first maximum height extending between the first contact surface and the second exterior contact surface and a second
orientation with the first angled section spaced apart from the second angled section and having an increased second maximum
height between the first contact surface and the second exterior contact surface.

US Pat. No. 10,070,908

SURGICAL INSTRUMENTS FOR CUTTING ELONGATED ELEMENTS AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. A surgical instrument for cutting an elongated element comprising:first and second arms each with an elongated shape, a distal section, a proximal section, and a cutting element positioned at the distal section;
the first arm further including a first aperture that extends longitudinally through at least a portion of the distal section and includes an inlet and an outlet spaced away from the inlet;
the distal section of the second arm further including a pair of spaced apart walls that form a longitudinal channel;
the distal section of the first arm being positioned in the channel of the second arm such that the distal section of the first arm overlaps the walls of the second arm;
a pivot member positioned in overlapping portions of the first and second arms, the pivot member being fixedly attached to the first arm and movable relative to the second arm, the pivot member including a second aperture that aligns with the first aperture;
a passage formed by the first aperture in the first arm and the second aperture in the pivot member, the passage extending through the pivot member to receive a portion of the elongated element; and
a force mechanism attached to the proximal sections of the first and second arms to pivot the first and second arms about the pivot member between an open orientation with the cutting elements spaced apart and a closed orientation with the cutting elements positioned in proximity to each other.

US Pat. No. 9,597,202

METHOD FOR USING A GUARD FOR CREATING A SOCKET POSTERIORLY IN THE SPINE

Warsaw Orthopedic, Inc., ...

1. A method for inserting a bone implant into a posterior aspect of a human spine, comprising:
placing a guard against the posterior aspect of the spine, the guard having a passage therethrough;
inserting a bone removal device into the passage of the guard, the bone removal device having a cutting portion;
removing a portion of a facet joint with the bone removal device; and
inserting a bone implant through the passage of the guard and into the spine, the bone implant having a leading end, a trailing
end, a mid-longitudinal axis through the ends, and a height transverse to the mid-longitudinal axis, the bone implant promoting
fusion between two adjacent vertebra.

US Pat. No. 9,451,999

SURGICAL INSTRUMENT ADAPTOR

Warsaw Orthopedic, Inc., ...

1. An adaptor comprising:
a member defining a longitudinal axis and being configured for connection to an image guide configured to generate a signal
representative of a position of a surgical instrument,

the member extending between a first end and a second end, and
the first end including a first mating part configured for releasable engagement with a mating part of an actuator and the
second end including a second mating part configured for releasable engagement with a mating part of the surgical instrument,

wherein the member comprises a shaft that includes a circumferential flange integrally formed with the shaft, wherein the
circumferential flange comprises opposite first and second end surfaces, an outer surface of the circumferential flange being
continuously tapered from the second end surface to the first end surface.

US Pat. No. 9,445,919

EXPANDABLE INTERBODY IMPLANT AND METHODS OF USE

Warsaw Orthopedic, Inc., ...

1. An intervertebral implant comprising:
a first component extending along a longitudinal axis and comprising an outer tissue engaging surface and an inner surface
opposite the outer tissue engaging surface comprising an inclined portion;

a second component connected to the first component such that the first component is pivotable relative to the second component
about a pin extending transverse to the longitudinal axis through the first and second components, the second component comprising
an outer tissue engaging surface and a planar inner surface opposite the outer tissue engaging surface of the second component
extending parallel to the longitudinal axis, the second component including an actuator comprising a distal end and an opposite
proximal end that includes a tool socket; and

a third component disposed for engagement and being movable relative to the first and second components, the third component
comprising a planar lower surface extending parallel to the longitudinal axis and an opposite upper surface including at least
a first ramp and a second ramp axially spaced apart from the first ramp,

wherein the pin is spaced apart from the third member and the distal end of the actuator comprises a flange that engages a
wall of the third component to retain the actuator with the third component and effect translation of the third component
in opposite directions along the longitudinal axis such that the planar lower surface of the third component slidably engages
the planar inner surface of the second component and the ramps slidably engage the inclined portion to move the components
between a first, collapsed configuration and a second, expanded configuration.

US Pat. No. 9,433,453

IMPLANT WITH AN INTERFERENCE FIT FASTENER

Warsaw Orthopedic, Inc., ...

1. A medical device for treating a patient comprising:
an implant comprising opposite superior and inferior surfaces that are each configured to engage vertebral tissue, the superior
and inferior surfaces each extending between opposite side walls;

a solid, non-threaded passage that extends through one of the sidewalls and the inferior surface of the implant without extending
through the superior surface, the passage including a first interference section with a first diameter, the first interference
section extending along an entire length of the passage, the first diameter being a constant diameter along the entire length
of the passage;

a fastener with an elongated shape and a distal end and a proximal end, the fastener including a second interference section
located between the ends that includes a second diameter that is greater than the first diameter;

one of the first and second interference sections constructed from a harder material and the other constructed from a softer
material;

a surface of the interference section constructed from the softer material being modified by insertion of the fastener into
the passage to create an interference fit between the implant and the fastener.

US Pat. No. 9,421,221

COMPOSITIONS AND METHODS FOR INHIBITING ADHESION FORMATION

Warsaw Orthopedic, Inc., ...

1. A matrix for reducing, preventing or treating adhesions in a patient in need thereof, the matrix comprising a biodegradable
polymer and dextran sulfate loaded in the matrix in an amount of at least 70 wt. % based on a total weight of the matrix,
wherein the matrix is configured to release from about 20% to about 90% of the dextran sulfate loaded in the matrix within
24 to 48 hours, and the matrix is in sponge form having a burst release surface that releases about 10% of the dextran sulfate
over 24 hours, and the biodegradable polymer comprises purified type I bovine fibrillar collagen comprising from about 1.0
wt. % to about 2.0 wt. % based on a total weight of the matrix, and an average sulfur content for the dextran sulfate is between
about 15 to 20%.

US Pat. No. 9,414,864

ANTERIOR SPINAL PLATE WITH PREFORMED DRUG-ELUTING DEVICE AFFIXED THERETO

Warsaw Orthopedic, Inc., ...

1. A drug-eluting device comprising a drug-eluting biocompatible matrix comprising a layer of a bioresorbable polymer and
at least one antibacterial elutable drug comprising clindamycin at a level of from 1 to about 20 weight percent of the drug-eluting
biocompatible matrix in combination with rifampin at a level of from 1 to about 20 weight percent of the drug-eluting biocompatible
matrix, and minocycline at a level of from 1 to about 20 weight percent of the drug-eluting biocompatible matrix, said device
comprising at least one locking element configured to attach with an anterior spinal plate, wherein the matrix comprises a
non-bioresorbable layer disposed in between the plate and the bioresorbable layer and each layer comprises distinct zones
of concentration within the matrix with the drugs clindamycin, rifampin and minocycline.