US Pat. No. 9,118,336

PHYSICAL SYSTEM FOR CHIP-SCALE CPT ATOMIC CLOCK

Wuhan Institute of Physic...

1. A physical system for a chip-scale coherent population trapping (CPT) atomic clock, the system comprising: a vertical-cavity
surface-emitting laser (VCSEL) device, a first polarizing beam splitter, a first ?/4 wave plate, a chip of an atomic vapor
cell, a second ?/4 wave plate, a reflection device, a lens, a second polarizing beam splitter, and a photo detector;
wherein
the first polarizing beam splitter, the first ?/4 wave plate, the chip of the atomic vapor cell, the second ?/4 wave plate,
and the reflection device are disposed in sequence;

the lens, the second polarizing beam splitter, and the photo detector are disposed in sequence;
a linearly polarized circular divergent beam is sent out by the VCSEL device and goes through the first polarizing beam splitter
to produce a first linearly polarized circular divergent beam;

the first linearly polarized circular divergent beam goes through the first ?/4 wave plate to produce a circularly polarized
circular divergent beam;

the circularly polarized circular divergent beam goes through the chip of the atomic vapor cell and the second ?/4 wave plate
respectively to produce a second linearly polarized circular divergent beam;

the second linearly polarized circular divergent beam is reflected by the reflection device to produce a first linearly polarized
reflected circular divergent beam;

the first linearly polarized reflected circular divergent beam goes through the lens to produce a first linearly polarized
parallel beam;

the first linearly polarized parallel beam is reflected by the second polarizing beam splitter to produce a first linearly
polarized reflected parallel beam;

the first linearly polarized reflected parallel beam is reflected by the first polarizing beam splitter and combined with
the first linearly polarized circular divergent beam; and

the first linearly polarized reflected parallel beam after being reflected by the first polarizing beam splitter goes through
the first ?/4 wave plate, the chip of the atomic vapor cell, the second ?/4 wave plate, respectively, is reflected by the
reflection device, goes through the lens, the second polarizing beam splitter, respectively, and is transmitted to the photo
detector and converted into a current output.

US Pat. No. 9,874,446

PHYSICAL UNIT OF CHIP-SCALE NMR GYROSCOPE

WUHAN INSTITUTE OF PHYSIC...

1. A physical unit of a chip-scale nuclear magnetic resonance (NMR) gyroscope, the physical unit comprising:
a) a vertical cavity surface emitting laser (VCSEL);
b) a silicon sheet comprising a recess, the recess comprising sides comprising reflecting mirrors;
c) a glass sheet;
d) an atomic vapor chamber;
e) a first right angle prism;
f) a quarter-wave plate;
g) a polarizing beam splitter; and
h) photodetectors;wherein:
the glass sheet is disposed on the silicon sheet;
the recess of the silicon sheet is in a structure of an inverted square frustum, and the reflecting mirrors are disposed on
sides of the recess; and

the atomic vapor chamber is an enclosed region formed between the recess and the glass sheet; andwhen in use:
the atomic vapor chamber is filled with alkali metal atoms, one or a plurality of inert gas atoms, and one or a plurality
of buffer gases;

a laser beam is transmitted from the VCSEL and is divided into a reflection beam and a transmission beam when passing through
the first right angle prism;

the reflection beam is reflected by a first reflecting mirror into the atomic vapor chamber as a probe light beam and interacts
with the atoms therein;

the transmission beam passes through the quarter-wave plate and is reflected by a second reflecting mirror into the atomic
vapor chamber as a pump light beam and interacts with the atoms therein;

the pump light beam and the probe light beam are orthogonal to each other within the atomic vapor chamber; and
the probe light beam after interacting with the atoms is reflected by a third reflecting mirror and is divided by the polarizing
beam splitter into two beams, and the two beams are detected by the photodetectors, respectively.

US Pat. No. 10,340,578

ELECTRON-NUCLEAR DOUBLE RESONANCE RESONATOR

Wuhan Institute of Physic...

1. An electron-nuclear double resonance resonator, comprisinga plurality of pairs of arc-shaped conductive plates, each of the arc-shaped conductive plates having side edges and being circumferentially distributed, two pairs of the arc-shaped conductive plates opposing each other and in each pair of the two pairs, the arc-shaped conductive plates facing each other with a recess on the adjacent side edge, and the recesses of the pairs of the arc-shaped conductive plates forming two radio-frequency coil windows, the plurality of the pairs of the arc-shaped conductive plates forming a cylindrical loop-gap resonator with the two radio-frequency coil windows, and the two radio-frequency coil windows being provided on the cylindrical loop-gap resonator opposing each other,
a lead connecting each of the arc-shaped conductive plates in series in turn to form a radio frequency coil that is a saddle-shaped coil having a same diameter as the cylindrical loop-gap resonator,
wherein
the radio-frequency coil generates a radio-frequency magnetic field that passes through the two radio-frequency coil windows in turn.

US Pat. No. 10,501,758

RECOMBINANT BACULOVIRUS AND METHOD FOR USING THE SAME FOR PREPARING RECOMBINANT ADENO-ASSOCIATED VIRUS VECTOR

WUHAN INSTITUTE OF PHYSIC...

1. A recombinant baculovirus, comprising: an adeno-associated virus (AAV) Rep gene, an AAV Cap gene, and a recombinant adeno-associated virus (rAAV) genome ITR-GOI (gene of interest) flanked by AAV inverted terminal repeats (ITR); wherein:the ITR-GOI comprises a 5? terminal nucleic acid fragment and a 3? terminal nucleic acid fragment; and
the ITR-GOI is linked to an expression cassette of the Cap gene and an expression cassette of the Rep gene through the 5? terminal nucleic acid fragment and the 3? terminal nucleic acid fragment, respectively.

US Pat. No. 10,921,191

ATOMIC SENSING METHOD AND CHIP-SCALE ATOMIC SENSOR

WUHAN INSTITUTE OF PHYSIC...

1. A method, comprising:1) providing a polarization converter;
2) emitting a linearly polarized polychromatic laser beam to the polarization converter;
3) converting, by the polarization converter, the linearly polarized polychromatic laser beam into a circularly-polarized laser beam and a linearly-polarized laser beam;
4) combining the circularly-polarized laser beam and the linearly-polarized laser beam thereby yielding a multi-polarization polychromatic laser beam;
5) transmitting the multi-polarization polychromatic laser beam to an atomic vapor cell comprising alkali metal atoms;
6) polarizing the multi-polarization polychromatic laser beam into two laser beams; and
7) detecting the two laser beams by two photodetectors, respectively.

US Pat. No. 10,705,169

DEVICE HAVING INERT GAS NUCLEUS CHANNEL AND METHOD FOR MAGNETIC RESONANCE IMAGING USING THE SAME

Wuhan Institute of Physic...

1. A device having an inert gas nucleus channel, comprisinga magnetic resonance control system,
a radio frequency generator having an input terminal and an output terminal,
a first mixer having a first input terminal, a second input terminal, and an output terminal,
a frequency synthesizer having an output terminal,
an inert gas nucleus coil,
a second power amplifier,
a second T/R switch having a transmission channel and a reception channel,
a second mixer having a first input terminal, a second input terminal, and an output terminal,
a second pre-amplifier, and
an RF amplifier and AD converter,
wherein the magnetic resonance control system is connected to the input terminal of the radio frequency generator,
the output terminal of the radio frequency generator is connected to the first input terminal of the first mixer,
the second input terminal of the first mixer is connected to the output terminal of the frequency synthesizer,
the output terminal of the first mixer is connected to the inert gas nucleus coil through the second power amplifier and the transmission channel of the second T/R switch,
the inert gas nucleus coil is connected to the first input terminal of the second mixer sequentially through the reception channel of the second T/R switch and the second pre-amplifier,
the second input terminal of the second mixer is connected to the output terminal of the frequency synthesizer,
the output terminal of the second mixer is connected to the magnetic resonance control system through the RF amplifier and AD converter, and
the magnetic resonance control system is connected to the second T/R switch.

US Pat. No. 10,795,171

OPTICAL-FIBER ATOMIC LIGHT-FILTERING APPARATUS

Wuhan Institute of Physic...

1. An optical-fiber atomic light-filtering apparatus, comprisingan optical-fiber coupling focusing collimating mirror,
a pure iron frame shaped like a Chinese character “” the pure iron frame shaped like the Chinese character “” further comprising a closed pure iron outer frame and a holed pure iron partition plate arranged in a middle of the pure iron outer frame, wherein the holed pure iron partition plate is provided with through holes, and the pure iron frame shaped like the Chinese character “” is partitioned by the holed pure iron partition plate into an upper cavity and a lower cavity,
a heat preservation box being arranged in the pure iron outer frame, wherein the heat preservation box is partitioned by the holed pure iron partition plate into an upper heat preservation box body and a lower heat preservation box body, the upper heat preservation box body is arranged in the upper cavity, the lower heat preservation box body is arranged in the lower cavity, and the upper heat preservation box body is communicated with the lower heat preservation box body via the through holes on the holed pure iron partition plate,
a first capillary atomic cell, the first capillary atomic cell being arranged in the upper heat preservation box body and having a first end and a second end,
a second capillary atomic cell, the second capillary atomic cell being arranged in the lower heat preservation box body and having a first end and a second end,
a first armored twisted-pair heating wire being arranged outside the first capillary atomic cell,
a second armored twisted-pair heating wire being arranged outside the second capillary atomic cell, wherein the first armored twisted-pair heating wire is connected with the second armored twisted-pair heating wire,
an armored twisted-pair heating wire formed by the connection of the first armored twisted-pair heating wire and the second armored twisted-pair heating wire,
a thermostat being connected with the armored twisted-pair heating wire through a cable,
a temperature sensor being connected with the thermostat and being arranged in the heat preservation box,
a first permanent magnetic ring and a second permanent magnetic ring, wherein the first permanent magnetic ring and the second permanent magnetic ring are arranged in the upper cavity and respectively located at two ends of the first capillary atomic cell,
a third permanent magnetic ring and a fourth permanent magnetic ring, wherein the third permanent magnetic ring and the fourth permanent magnetic ring are arranged in the lower cavity and respectively located at two ends of the second capillary atomic cell,
a first polarizing optical fiber having a first end and a second end, wherein the first end of the first polarizing optical fiber is connected with the optical-fiber coupling focusing collimating mirror, and the second end of the first polarizing optical fiber sequentially penetrate through the pure iron frame shaped like the Chinese character “,” an inner hole of the first permanent magnetic ring, and the upper heat preservation box body to be connected with the first end of the first capillary atomic cell,
a second polarizing optical fiber having a first end and a second end, wherein the first end of the second polarizing optical fiber sequentially penetrate through the pure iron frame shaped like the Chinese character “,” an inner hole of the second permanent magnetic ring, and the upper heat preservation box body to be connected with the second end of the first capillary atomic cell, and the second end of the second polarizing optical fiber sequentially penetrates through the pure iron frame shaped like the Chinese character “,” an inner hole of the third permanent magnetic ring, and the lower heat preservation box body to be connected to the first end of the second capillary atomic cell, and
a third polarizing optical fiber having a first end and a second end, wherein the first end of the third polarizing optical fiber sequentially penetrates through the pure iron frame shaped like the Chinese character “,” the fourth permanent magnetic ring, and the lower heat preservation box body to be connected with the second end of the second capillary atomic cell, and
a photoelectric detector, the photoelectric detector being connected to the second end of the third polarizing optical fiber.
US Pat. No. 10,829,784

METHOD FOR PREPARING RECOMBINANT ADENO-ASSOCIATED VIRUS

WUHAN INSTITUTE OF PHYSIC...

1. A method for producing recombinant adeno-associated virus, the method comprising:(1) transforming a gene of interest (GOI) into a recombinant baculovirus, wherein the recombinant baculovirus has a genome integrated with AAV Rep gene, Cap gene, and rAAV genome ITR-GOI; and the ITR-GOI is linked to expression cassette of the Cap gene and the Rep gene by a 5? terminal nucleic acid segment or a 3? terminal nucleic acid segment of the ITR-GOI; and the 5? terminal nucleic acid segment or the 3? terminal nucleic acid segment is a ligation nucleic acid sequence having a length ranging from 80 to 140 bp;
(2) infecting host insect larvae with the recombinant baculovirus prepared in (1) to produce the rAAV in vivo in the host insect larvae; and
(3) lysing the host insect larvae obtained in (2), and extracting and purifying the rAAV,
wherein the infecting host insect larvae with the recombinant baculovirus prepared in (1) to produce the rAAV in vivo in the host insect larvae comprises:
(2-1-1): feeding hatched host insect larvae to between a 4th instar stage and a 5th instar stage;
(2-1-2): inoculating the host insect larvae obtained in (2-1-1) by subcutaneously injecting 10-20 ?L, of the recombinant baculovirus at a titer of 1×107 VG/mL to 1×109 VG/mL prepared in (1); and
(2-1-3): feeding the host insect larvae injected with the recombinant baculovirus obtained in (2-1-2) until the larvae have the symptoms of appetite loss, sluggish movement, and swollen somite, and then stopping feeding, and harvesting the larvae.