US Pat. No. 9,532,890

IMPLANTABLE EXPANDABLE MEDICAL DEVICES HAVING REGIONS OF DIFFERENTIAL MECHANICAL PROPERTIES AND METHODS OF MAKING SAME

Vactronix Scientific, Inc...

1. An implantable, geometrically expandable, generally tubular, nickel-titanium medical device, comprising:
a. a plurality of circumferentially self-expansible members interconnected by a plurality of first hinge regions;
b. a plurality of interconnecting members interconnecting adjacent pairs of circumferentially self-expansible members, the
plurality of interconnecting members having a first portion and a second portion comprising a greater part of the interconnecting
member than a second hinge member disposed between the first and second portions, the first and second portions being oblique
to the second hinge member at a point immediately adjacent to a junction between the second hinge member and either the first
or the second portions, wherein the majority of the second hinge member is martensitic in vivo and the first and second portions
are austensitic in vivo;

c. where each of the plurality of first hinge regions permits circumferential expansion of the device by at least one of elastic
or pseudoelastic deformation in vivo; and

d. where each of the plurality of second hinge regions is capable of deforming by at least one of plastic or pseudoplastic
deformation along a longitudinal axis of the device in vivo under the influence of a flexing load.

US Pat. No. 9,566,148

SELF-SUPPORTING LAMINATED FILMS, STRUCTURAL MATERIALS AND MEDICAL DEVICES MANUFACTURED THEREFROM AND METHODS OF MAKING SAME

Vactronix Scientific, Inc...

1. A medical device comprising a tubular self-supporting laminated structural member composed of metal films, foils, wires,
or seamless tubes, the tubular self-supporting laminated structural member having a first layer of a first metal biocompatible
material having a luminal surface disposed entirely within an abluminal surface of the first layer and a second layer of a
second metal biocompatible material integral with and extending radially from a fractional region of the abluminal surface
of the first layer, wherein the second layer of the second metal biocompatible material defines a plurality of structural
members, the structural members defining open regions therebetween in the second layer, and the first layer of the first metal
biocompatible material subtends substantially all of the open regions between adjacent pairs of the plurality of structural
members in the second layer.

US Pat. No. 9,566,633

STENTS HAVING A HYBRID PATTERN AND METHODS OF MANUFACTURE

Vactronix Scientific, Inc...

1. An implantable medical device comprising:
a. a plurality of circumferentially expansible members each comprising geometrically deformable closed cells interconnected
along a circumferential axis forming a tubular structure with a longitudinal axis;

b. a plurality of bridge members interconnecting the plurality of circumferentially expansible members along the longitudinal
axis, each bridge member forming a continuous undulating waveform linking a first interconnection between two geometrically
deformable closed cells in a first circumferentially expansible member of the plurality of circumferentially expansible members
at a peak of the continuous undulating waveform to a second interconnection between two geometrically deformable cells in
a second circumferentially expansible member of the plurality of circumferentially expansible members at a trough of the continuous
undulating waveform, wherein a peak to trough height of the waveform is defined by a number of geometrically deformable closed
cells interconnected along a circumferential axis between the peak and the trough; and

c. each of the plurality of bridge members is separated by at least two geometrically deformable closed cells of the plurality
of geometrically deformable closed cells interconnected along the circumferential axis of each of the plurality of circumferentially
expansible members.

US Pat. No. 9,662,230

IMPLANTABLE MEDICAL DEVICES HAVING CONTROLLED SURFACE PROPERTIES FOR IMPROVED HEALING RESPONSE

VACTRONIX SCIENTIFIC, INC...

1. An implantable medical device comprising: a vacuum deposited biomaterial, the implantable medical device having a substantially
tubular configuration with a luminal surface thereof, the luminal surface having a non-random distribution of cell attachment
sites or binding domains thereupon, the distribution being substantially homogenous about the luminal surface, the cell attachment
cites or binding domains further including oxidation and organic adsorption patterns.

US Pat. No. 9,788,980

METHOD FOR MAKING GROOVES ON A LUMINAL SURFACE OF AN INTRAVASCULAR STENT

Vactronix Scientific, Inc...

1. A method of manufacturing an intravascular stent comprising the steps of: forming an intravascular stent having a longitudinal
axis; an inner surface and an outer surface; and forming at least one groove on the inner surface of the stent by a thermal
process, wherein the at least one groove is disposed in a cross-hatched manner, substantially parallel with the longitudinal
axis, or substantially perpendicular with the longitudinal.

US Pat. No. 9,668,852

METALLIC IMPLANTABLE GRAFTS AND METHOD OF MAKING SAME

Vactronix Scientific, Inc...

1. An implantable medical graft, comprising:
a. A generally seamless continuous tubular body member comprising a film selected from the group consisting of metallic and
pseudometallic materials and having a luminal wall surface, an abluminal wall surface, and a wall thickness intermediate the
luminal wall surface and the abluminal wall surface; and

b. At least a portion of the body member having a plurality of circumferential corrugations defined by a radially undulating
pattern of longitudinally alternating radially extending peaks and valleys in the abluminal wall surface of the body member
and a radially undulating longitudinally alternating pattern of radially extending peaks and valleys in the luminal wall surface
of the body member, wherein each peak in the luminal surface is longitudinally coincident with each peak in the abluminal
surface and each valley in the luminal surface is longitudinally coincident with each valley in the abluminal surface, wherein
a plurality of microperforations is disposed through the wall thicknesses composing the coincident peaks and the wall thicknesses
composing the coincident valleys and wherein the plurality of microperforations provide fluid migration between the luminal
and abluminal wall surfaces.

US Pat. No. 9,640,359

INVERTED CYLINDRICAL MAGNETRON (ICM) SYSTEM AND METHODS OF USE

Vactronix Scientific, Inc...

1. An inverted cylindrical magnetron (ICM) source comprising:
a co-axial central anode concentrically located within a first annular end anode and a second annular end anode;
a process chamber including a top end and a bottom end in which the first annular end anode and the second annular end anode
are coaxially disposed, whereby the first annular end anode, the second annular end anode, and the central anode form a 3-anode
configuration to provide electric field uniformity, and the process chamber including a central annular space wall coupled
to a tube insulator disposed about the central annular space wall;

a cathode concentrically coupled to the tube insulator and a target;
a plurality of multi-zone magnets surrounding the exterior of the process chamber providing a tunable magnetic field;
a temperature adjustable target cooling jacket coaxially disposed between the tube insulator and the target; and wherein the
plurality of multi-zone magnets are selected from the group consisting of electromagnets or hybrid electro-permanent magnets;

a plurality of working gas flow inlets and a plurality of pumping ports with adjustable flowing and pumping rates operably
coupled to the process chamber to provide a top flow, a top pumping, a bottom pumping, and a bottom flow; wherein the top
flow pressure and the bottom flow pressure can be independently adjusted;

an adjustable gap between cathode and the co-axial central anode; and
wherein the co-axial central anode includes a plurality of working gas inlets to provide a gas supply into the process chamber.

US Pat. No. 10,039,866

IMPLANTABLE MATERIALS HAVING ENGINEERED SURFACES AND METHOD OF MAKING SAME

VACTRONIX SCIENTIFIC, LLC...

7. An implantable, biocompatible material, comprising a plurality of layers of biocompatible materials formed upon one another into a self-supporting multilayer structure, wherein the plurality of layers includes a vacuum deposited surface layer having a homogeneous molecular pattern of distribution along the surface thereof and comprises a patterned array of geometric physiologically functional features configured as endothelial cell binding domains.

US Pat. No. 10,034,967

IMPLANTABLE BIOMATERIALS HAVING ENGINEERED FUNCTIONAL SURFACES

VACTRONIX SCIENTIFIC, LLC...

1. An implantable biomaterial having at least one surface thereof that comprises the biomaterial and a defined pattern of a plurality of functional features having a height above the at least one surface greater than 0?, each of the plurality of functional features having a greater endothelial cell binding affinity greater than an endothelial cell binding affinity of the biomaterial.

US Pat. No. 9,987,398

PATTERN TRANSFER DEVICE FOR MASS TRANSFER OF MICRO-PATTERNS ONTO MEDICAL DEVICES

VACTRONIX SCIENTIFIC, LLC...

1. A patterned masked electrode, comprising:a. A generally cylindrical electrically conductive electrode member having an outer surface, a first end, a second end and a stent mounting region intermediate the first end and the second end;
b. A non-conductive coating on the outer surface of the electrode member; and
c. A micro-pattern defined in the non-conductive coating passing through the non-conductive coating and exposing defined portions of the electrode member, the micro-pattern corresponding to a plurality of continuous elongate slots adapted to transfer electrical energy through the micro-pattern of a plurality of continuous elongate slots to a luminal surface of a stent positioned on the stent mounting region, and each of the plurality of continuous elongate slots extend along an entire longitudinal axis of the stent mounting region.

US Pat. No. 10,172,730

STENTS WITH METALLIC COVERS AND METHODS OF MAKING SAME

Vactronix Scientific, LLC...

1. A tubular medical device having an inner luminal surface and outer abluminal surface, comprising:a) a structural support member having first and second wall surfaces thereof, the structural support member having at least one open space passing through the first and second wall surfaces, and being comprised of at least one of a metallic and pseudometallic laminate material; and
b) at least one tubular cover member consisting of a coherent laminate film of at least one of a metallic and pseudometallic material, the at least one tubular cover member being positioned adjacent against at least a portion of both the luminal and abluminal surfaces of the medical device and covering the at least one open space of the structural support member.

US Pat. No. 10,206,772

IMPLANTABLE MEDICAL DEVICE HAVING ENHANCED ENDOTHELIAL MIGRATION FEATURES AND METHODS OF MAKING THE SAME

Vactronix Scientific, LLC...

1. An implantable endoluminal stent, comprising:a plurality of structural members, each of the plurality of structural members having an irregular polygonal transverse cross-sectional profile and defined by a plurality of surface facets, some of the plurality of surface facets defining a luminal surface and some of the plurality of surface facets defining an abluminal surface of the endoluminal stent; and
wherein the plurality surface facets defining the luminal surface of the endoluminal stent further comprise a concave curvilinear first surface facet having a second end projecting toward a luminal center, a concave curvilinear second surface facet having a first end projecting toward a luminal center and a planar third surface facet intermediate between and joining the first surface facet second end and the second surface facet first end.

US Pat. No. 10,259,080

ADAPTIVE GUIDE BUSHING FOR LASER TUBE CUTTING SYSTEMS

Vactronix Scientific, LLC...

1. A laser cutting system comprising:an adaptive guide bushing, the adaptive guide bushing comprising:
a. a bushing holder having a proximal end and a distal end, wherein the distal end of the bushing holder further comprises a raised feature having a proximal end, a distal end, and a first opening traversing a thickness between the proximal end and the distal end of the raised feature;
b. a first bushing and a second bushing, wherein the first bushing is at least partially disposed within the first opening of the raised feature at the proximal end and the second bushing is at least partially disposed within the first opening of the raised feature at the distal end; and
c. an elastic member concentrically disposed within the first opening and positioned between and adjacent to each of the first bushing and the second bushing, wherein the elastic member has an aperture with a diameter configured to expand to accommodate tubing and contract to retain the tubing within the first opening.

US Pat. No. 10,143,574

MONOLITHIC MEDICAL DEVICES, METHODS OF MAKING AND USING THE SAME

Vactronix Scientific, LLC...

1. An intravascular stent device comprising:a plurality of circumferential ring members, each circumferential ring member having a plurality of struts defining a Z-pattern having a plurality of peaks defined by vertices formed from interconnecting adjacent struts and a plurality of troughs defined by an open space bounded by three sequential vertices, the plurality circumferential ring members are positioned along a longitudinal axis of the intravascular stent device in a spaced apart relationship relative to each other;
a plurality of generally S-shaped second members, each of the plurality of generally S-shaped second members having a first elliptical section and a second elliptical section, the first elliptical section being connected to a peak of a first circumferential ring member and the second elliptical section being connected to a circumferentially adjacent peak of a second circumferential ring member longitudinally adjacent the first circumferential ring member; and
wherein, when the intravascular stent device is in an expanded state, the first elliptical section is positioned between circumferentially adjacent peaks of the second circumferential ring member and nested within the open space of a trough of the second circumferential ring member and the second elliptical section is positioned between circumferentially adjacent peaks of the first circumferential ring member and nested within a trough of the open space of the first circumferential ring member.

US Pat. No. 10,106,884

COMPLIANT IMPLANTABLE MEDICAL DEVICES AND METHODS OF MAKING SAME

Vactronix Scientific, LLC...

1. An implantable medical device, comprising: a. a non-coiled tubular body member consisting essentially of a metallic or pseudometallic material film having a first surface, a second surface and a thickness intermediate the first surface and the second surface, the thickness being between 0.1 ?m to 75 ?m; and b. a plurality of microperforations passing through the thickness of the body member and communicating between the first surface and the second surface, whereby said plurality of microperforations are configured to geometrically deform, thereby allowing diametric expansion and both circumferential and longitudinal compliance of the body member.

US Pat. No. 10,092,390

METHOD OF MAKING IMPLANTABLE MEDICAL DEVICES HAVING CONTROLLED SURFACE PROPERTIES

Vactronix Scientific, LLC...

1. A method for controlling surface properties of an implantable medical device, comprising:vacuum depositing a device forming biomaterial selected from one of elemental nickel and elemental titanium or nickel-titanium alloy onto a cylindrical substrate maintained at a temperature range between about 300 to 1100 degrees Centigrade, the substrate having a pre-determined pattern of recesses in an outer surface thereof to form a tubular device forming biomaterial on the cylindrical substrate;
controlling the formation of heterogeneities at a blood or tissue contacting surface of the tubular device forming biomaterial during the vacuum depositing step, such that controlled heterogeneities are formed at the blood or tissue contacting surface; and
removing the medical device from the substrate.

US Pat. No. 10,363,125

METHOD OF MAKING IMPLANTABLE MEDICAL DEVICES HAVING CONTROLLED SURFACE PROPERTIES

Vactronix Scientific, LLC...

1. A method for controlling surface properties of an implantable medical device, comprising:a. vacuum depositing at least one device forming metal selected from one of elemental nickel, elemental titanium, chromium-cobalt alloy, nickel-titanium alloy and nickel-titanium ternary alloy onto a cylindrical substrate maintained at a temperature range between about 300 to 1100 degrees Centigrade, to form a tubular device forming biomaterial on the cylindrical substrate;
b. controlling the formation of heterogeneities at a blood or tissue contacting surface of the tubular device forming biomaterial during the vacuum depositing step, such that controlled heterogeneities are formed at the blood or tissue contacting surface; and
c. removing the formed biomaterial from the substrate.

US Pat. No. 10,433,989

STENTS HAVING A HYBRID PATTERN AND METHODS OF MANUFACTURE

Vactronix Scientific, LLC...

1. A method of making an intravascular stent, comprising the steps of:a. providing a thin film of material having a predetermined thickness and width;
b. patterning a stent pattern onto at least one surface of the thin film, wherein the pattern comprises a first plurality of interconnected closed cells connected along a first lateral axis, and at least a second plurality of interconnected closed cells connected along a second lateral axis longitudinally offset from the first lateral axis, the first plurality of interconnected closed cells and the at least a second plurality of interconnected closed cells interconnected by a plurality of bridge members along a longitudinal axis, each bridge member forming a continuous undulating waveform linking a first interconnection between two closed cells in the first plurality of interconnected closed cells at a peak or a trough of the continuous undulating waveform to a second interconnection between two interconnected closed cells in the at least second plurality of interconnected closed cell members at a respective trough or a respective peak of the continuous undulating waveform;
c. winding the thin film around a cylindrical mandrel;
d. forming the wound thin film into a generally tubular stent shape.

US Pat. No. 10,398,830

DEVICE FOR IN VIVO DELIVERY OF BIOACTIVE AGENTS AND METHOD OF MANUFACTURE THEREOF

Vactronix Scientific, LLC...

1. An endoluminal stent for delivering a bioactive agent to a situs in a body comprising:a radially expandable cylindrical member formed of a plurality of undulating hollow members, each of the plurality of undulating hollow members abutting a portion of an adjacent undulating hollow member and each of the plurality of undulating hollow members being joined to an adjacent undulating hollow member;
a continuous void space formed entirely within at least one of the plurality of undulating hollow members, wherein the continuous void space is bounded by internal wall surfaces of the at least one of a plurality of undulating hollow tubular members, the internal wall surface having a thickness;
a plurality of pores formed in and passing through an external wall surface and internal wall surface thickness of at least one of the plurality of undulating hollow tubular members and communicating between the continuous void space and the external wall surface and being open to an exterior surface of the radially expandable cylindrical element, further wherein each of the pores has a cross section smaller than a smallest cross section of the continuous void space; and at least one bioactive agent retained within the continuous void space and elutable through the plurality of pores.

US Pat. No. 10,373,767

STRUCTURAL SUPERCAPACITOR COMPOSITE AND METHOD OF MAKING SAME

VACTRONIX SCIENTIFIC, LLC...

1. An electrical capacitor assembly, comprising a plurality of modular electrical capacitors formed into a three-dimensional structural member and coupled to a primary electrical power source, each of the plurality of electrical capacitors comprising at least one conductive layer having at least one conductive projection extending from the at least one conductive layer and at least one dielectric layer adjacent to the at least one conductive layer; wherein adjacent electrical capacitors are electrically coupled to each other by engaging the at least one conductive projection of a first electrical capacitor with the at least one conductive layer of a second electrical capacitor adjacent the first electrical capacitor.

US Pat. No. 10,327,925

ENDOLUMINAL DEVICE FOR IN VIVO DELIVERY OF BIOACTIVE AGENTS

Vactronix Scientific, LLC...

1. A method of making an implantable device comprising:a. forming a base layer of structural material;
b. depositing a pattern of sacrificial material onto the base layer, the sacrificial material forming internal cavity regions;
c. depositing at least a second layer of structural material over the sacrificial material and over the base layer forming a strut having a an upper surface, lower surface, and lateral surface bounding the sacrificial material;
d. forming one or more microholes in the structural material providing fluid flow communication between the sacrificial material and the area external to the at least one of upper surface, lower surface, or lateral surface; and
e. removing the sacrificial material forming at least one internal cavity bound intermediate the upper surface, lower surface, and lateral surface wherein the one or more microholes are in fluid communication with the internal cavity.

US Pat. No. 10,292,849

BALLOON CATHETER HAVING METAL BALLOON AND METHOD OF MAKING SAME

Vactronix Scientific, LLC...

1. A catheter comprising: at least two balloons, the at least two balloons comprising a first metallic balloon, the first metallic balloon having a solid balloon thickness, the balloon thickness consisting of metal, and a second polymer balloon, the at least two balloons positioned concentrically relative to each other and at least one annular lumen defined there between.

US Pat. No. 10,465,274

IMPLANTABLE GRAFT AND METHODS OF MAKING SAME

Vactronix Scientific, LLC...

1. An endoluminal covered-stent including a radially expandable stent having a proximal end, a distal end and an intermediate region between the proximal end and the distal end and at least one of a plurality of attachment members configured to attach to a metal stent cover member, the radially expandable stent having a plurality of interconnected structural members and a plurality of stent fenestrations, the improvement comprising:a) the metal stent cover member being comprised of a generally tubular thin film metal cover member having a plurality of microporous openings and a thickness between about 0.1? to about 20?, wherein each of the plurality of microporous openings has an open surface area less than an open surface area of each of the plurality of stent fenestrations, the generally tubular thin film metal cover member is concentrically joined to at least one of a luminal surface or an abluminal surface of the stent and joined to the stent only at the plurality of attachment members, such that the generally tubular thin film metal cover member at least partially occludes the plurality of stent fenestrations; and
b) wherein the joined radially expandable stent and the generally tubular thin film metal cover member are capable of radial expansion together with one another.

US Pat. No. 10,449,030

SELF-SUPPORTING LAMINATED FILMS, STRUCTURAL MATERIALS AND MEDICAL DEVICES MANUFACTURED THEREFROM AND METHODS OF MAKING SAME

Vactronix Scientific, LLC...

1. An implantable medical graft comprising an abluminal film composed of biocompatible metal layers and a self-supporting luminal film concentrically positioned within the abluminal film, wherein the self-supporting luminal film is composed of biocompatible metal layers, wherein an interfacial region is defined where the abluminal film and luminal film are in immediate juxtaposition and co-extensive with one another; and the interfacial region has a thermodynamic parameter change relative to a thermodynamic parameter of the abluminal film or the luminal film, each of the abluminal film and luminal film having a plurality of openings passing there through, wherein each opening of the plurality of openings are dimensioned to be capable of permitting cellular migration without permitting fluid flow there through.

US Pat. No. 10,357,354

MONOLITHIC BIOCOMPATIBLE IMPLANTABLE LAMINATED MATERIALS

Vactronix Scientific, LLC...

6. A biocompatible implantable material, comprising a substantially monolithic structural member comprising an implantable medical device, the substantially monolithic structural member having plural layers selected from the group of metal and metal-like materials, each of the plural layers having a columnar grain structure, wherein adjacent layers of the plural layers have a discontinuous columnar grain structure relative to each other.

US Pat. No. 10,314,949

IMPLANTABLE BIOMATERIALS HAVING FUNCTIONAL SURFACES

Vactronix Scientific, LLC...

1. An implantable medical device made from a biocompatible material, the biocompatible material forming at least one surface of the implantable medical device, the at least one surface of the biocompatible material further having a patterned array of functional features on the at least one surface of the biocompatible material, wherein each of functional features has a surface energy higher than a surface energy of a remainder of the at least one surface of the biomaterial, and wherein the patterned array of functional features has a spacing between adjacent functional features configured to promote cell propagation between adjacent functional features and along the at least one surface of the implantable medical device.

US Pat. No. 10,258,719

PATTERN TRANSFER DEVICE FOR MASS TRANSFER OF MICRO-PATTERNS ONTO MEDICAL DEVICES

Vactronix Scientific, LLC...

1. A patterned masked electrode, comprising: a. A generally cylindrical electrically conductive electrode member having an outer surface, a first end, a second end and a workpiece mounting region intermediate the first end and the second end; b. A non-conductive coating on the outer surface of the electrode member; and c. A micro-pattern defined in the non-conductive coating passing through the non-conductive coating and exposing defined portions of the electrode member, the micro-pattern corresponding to a plurality of continuous elongate slots adapted to transfer electrical energy through the micro-pattern of a plurality of continuous elongate slots to a surface of a workpiece positioned on the workpiece mounting region, and each of the plurality of continuous elongate slots extend along an entire longitudinal axis of the workpiece mounting region.