US Pat. No. 9,486,621

IMPLANTING AN ELECTRODE ARRAY AGAINST THE SPINAL CORD INSIDE THE DURA FOR STIMULATING THE SPINAL CORD AND TREATING PAIN

University of Iowa Resear...

1. A method of intradurally implanting an electrode assembly in a subject against the spinal cord, comprising:
(a) surgically preparing the subject by exposing the dura that surrounds the subject's spinal cord;
(b) making an opening in the dura;
(c) inserting the electrode assembly though the opening so that a plurality of electrodes on the electrode assembly are placed
in direct contact with the surface of the spinal cord at a treatment site inside the dura;

(d) securing the electrode assembly such that the electrodes stay in place and the cerebrospinal fluid (CSF) filled space
is maintained, thereby sustaining direct contact between the plurality of electrodes and the surface of the spinal cord at
the treatment site while allowing CSF to flow between the electrode assembly and the dura; and

(e) surgically closing the dura around the electrode assembly.

US Pat. No. 9,604,890

COMPOSITIONS AND METHODS FOR HYDROCARBON FUNCTIONALIZATION

The Trustees of Princeton...

1. A method, comprising:
mixing AaXn, an iodine-based compound, and a source of functionalization to form a first mixture, wherein A is selected from the group
consisting of: hydrogen, lithium, sodium, potassium, beryllium, magnesium, calcium, strontium, barium, transition metals,
aluminum, gallium, thallium, indium, tin, sulfur, ammonium (NH4+), alkylammonium, phosphonium (PH4+), alkylphosphonium, arylphosphonium, or trimethyl sulfonium ([S(CH3)3]+) and a combination thereof, wherein X is chlorine or bromine, wherein subscript “a” is an oxidation state of X and subscript
“n” is an oxidation state of A; and

mixing the first mixture with a hydrocarbon in the gas phase to make a functionalized hydrocarbon.
US Pat. No. 9,468,660

ANTINEMATODAL METHODS AND COMPOSITIONS

Technion Research and Dev...

1. A method for fusing a first mammalian cell and a second mammalian cell; comprising:
(i) incubating a first mammalian cell expressing a nematode fusogenic protein with a second mammalian cell expressing a nematode
fusogenic protein; and

(ii) fusing the first and second mammalian cells, wherein the nematode fusogenic protein is selected from the group consisting
of anchor-cell fusion failure 1 (AFF-1) and epithelial fusion failure 1 (EFF-1) and wherein the first and second mammalian
cells are of the same species.

US Pat. No. 9,364,660

ELECTRODE ARRAY DEVICE CONFIGURED FOR PLACEMENT INSIDE THE DURA FOR DIRECT SPINAL CORD STIMULATION

University of Iowa Resear...

1. A system for treating pain in a patient, comprising:
(1) an electrode assembly configured for intradural implantation, which includes:
(a) a compliant backing;
(b) a plurality of electrodes forming an array along a surface of the backing;
(c) a support structure configured to secure the electrodes directly in contact with the spinal cord; and
(2) circuitry configured for electrical coupling with the electrodes to deliver electrical through the electrodes to a targeted
subregion of the spinal cord;

wherein the electrode assembly is configured to conform to the pial surface of the spinal cord of the patient, and has a sufficiently
thin profile such that when the array of electrodes is placed against the pial surface, the CSF filled space is maintained,
thereby separating the dura from the spinal cord, preventing mechanical constriction and obstruction of CSF flow between the
electrode assembly and the dura; and

wherein the electrodes are arrayed on the backing so as to provide a sufficiently concentrated stimulus field such that electrical
stimuli can be administered to the whole treatment zone from inside the dura without exciting dorsal nerve rootlets.

US Pat. No. 10,054,656

METHOD AND APPARATUS THAT ACQUIRE MAGNETIC RESONANCE DATA USING A 3D TURBO OR FAST SPIN ECHO PULSE SEQUENCE WITH A LENGTHENED ECHO SPACING

Siemens Healthcare GmbH, ...

1. A method of acquiring magnetic resonance (MR) data from a subject, comprising:with a computer, accessing or generating a modified form of a standard 3D turbo or fast spin echo (3D-TSE/FSE) imaging protocol, with said standard 3D-TSE/FSE imaging protocol comprising at least one echo spacing following a radiation of an excitation radio-frequency (RF) pulse, wherein a length of said at least one echo spacing in said standard 3D-TSE/FSE imaging protocol is determined by the radiation of a number of refocusing RF pulses, via an RF channel that comprises an RF amplifier, and a subsequent readout of an echo produced by nuclear spins excited by the radiated excitation RF pulse which have also been refocused by each refocusing RF pulse in said standard 3D-TSE/FSE imaging protocol;
from said computer, operating said MR data acquisition unit with a reduced loading of said RF amplifier, where the reduced loading of the RF amplifier is produced by modifying said at least one echo spacing of the standard 3D-TSE/FSE imaging protocol in order to lengthen the length of the at least one echo spacing to more than 500 ms, while also radiating a modified number of refocusing RF pulses that is less than the number of said refocusing RF pulses that occur in said standard 3D-TSE/FSE imaging protocol, and said MR data acquisition unit thereby acquiring raw MR data that is or has been read out from said echo; and
in said computer, executing an image reconstruction algorithm in order to convert said acquired raw MR data into MR image data representing an image of the subject, and making the MR image data that represents the image of the subject available in electronic form at an output of said computer.

US Pat. No. 9,910,118

SYSTEMS AND METHODS FOR CARTESIAN DYNAMIC IMAGING

University of Virginia Pa...

1. A method, comprising:
acquiring magnetic resonance data for an area of interest of a subject that is associated with at least one physiological
activity of the subject, wherein acquiring the magnetic resonance data comprises Cartesian sampling, and wherein the Cartesian
sampling comprises Cartesian k-space measurement wherein undersampling is performed in a phase encoding direction and k-space
is fully sampled or oversampled in a readout direction; and

performing image reconstruction comprising Kalman filtering or smoothing on Cartesian images of a Cartesian dynamic image
series associated with the acquired magnetic resonance data,

wherein the image reconstruction comprises increasing at least one of spatial or temporal resolution of the Cartesian images,
and

wherein a direct one-dimensional Fourier transform is performed along the readout direction and a Kalman filter is applied
for the image reconstruction along the phase encoding direction.

US Pat. No. 9,317,657

METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR TRACKING OF BLOOD GLUCOSE VARIABILITY IN DIABETES

University of Virginia Pa...

1. A system for visually tracking blood glucose variability in diabetes in a subject, said system comprising:
an acquisition module acquiring a plurality of blood glucose data of the subject over a predefined period of time;
a processor programmed to
compute blood glucose variability of the subject over said predefined period of time using said blood glucose data; and
plot the computed blood glucose variability on an output display in the form of data points on a graph having a coordinate
system representing hypoglycemic risk along one axis of said graph and hyperglycemic risk along another axis of said graph;

wherein the location of a data point in said coordinate system of said graph represents a variable degree of control of blood
glucose levels of said subject; and

wherein said tracking provides an area of optimal glucose control in said graph, and provides areas in said graph indicating
risk for hyperglycemia and hypoglycemia.

US Pat. No. 9,067,207

OPTICAL APPROACH FOR MICROFLUIDIC DNA ELECTROPHORESIS DETECTION

UNIVERSITY OF VIRGINIA PA...

1. A DNA analyzer, comprising:
an interface for coupling a microfluidic chip to the DNA analyzer, wherein the microfluidic chip includes:
a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, the DNA fragments being tagged
with fluorescent labels; and

a second domain fluidically coupled to the first domain to receive the DNA fragments, the second domain having a separation
channel for electrophoretic separation of the DNA fragments; and

a detection module configured to be optically coupled with the microfluidic chip that includes:
a laser source configured to generate a laser beam;
a set of optical elements configured to direct the laser beam to the separation channel to excite the fluorescent labels to
emit fluorescence while the DNA fragments migrate in the separation channel, and to collect the emitted fluorescence into
an optical signal, the set of optical elements including an objective lens configured to be aligned with the separation channel
to direct the laser beam to the separation channel and to collect the emitted fluorescence from the separation channel;

a motor configured to align the objective lens to the separation channel:
a filter module configured to filter the optical signal to allow a first portion of the optical signal having a first wavelength
to pass;

a photo-detector configured to generate an electrical detection signal in response to the filtered optical signal;
a modulation signal generator coupled to the filter module, the modulation signal generator being configured to generate a
modulation signal having a modulation frequency, and a reference signal having the modulation frequency, the modulation signal
being used by the filter module to modulate the filtered optical signal; and

a phase-sensitive detector configured to receive the reference signal and the electrical detection signal corresponding to
the modulated filtered optical signal, and demodulate the electrical detection signal based on the reference signal to remove
noise due to the photo-detector.

US Pat. No. 9,853,502

ENERGY HARVESTING AND CONTROL FOR SENSOR NODE

UNIVERSITY OF VIRGINIA PA...

1. A sensor node, comprising:
a regulator circuit including an input coupleable to an energy harvesting transducer;
a wireless receiver circuit coupled to the regulator circuit and configured to wirelessly receive at least enough operating
energy to establish operation of the sensor node without requiring the energy harvesting transducer;

a digital processor circuit coupled to the regulator circuit; and
a power management processor circuit configured to select an energy consumption level of the sensor node based on an input
to the regulator circuit;

wherein the digital processor circuit includes a subthreshold operational mode established by the power management processor
circuit based on the selected energy consumption level; and

wherein establishing the subthreshold operational mode includes adjusting or selecting a supply voltage provided by the regulator
circuit so as to establish subthreshold operation of a field effect transistor (FET) in the digital processor circuit.

US Pat. No. 9,977,652

SYSTEM, METHOD, AND COMPUTER-READABLE MEDIUM FOR HIGH THROUGHPUT PSEUDO-RANDOM NUMBER GENERATION

University of Virginia Pa...

1. A method for generating pseudo-random numbers, comprising:receiving, by at least one processor, range data indicating a range of numbers;
generating, based on the range data and by the at least one processor, a digitized finite state machine configured to produce pseudo-random output within the range of numbers;
providing, by the at least one processor to a specialized pattern-matching device, programmable instructions to implement the digitized finite state machine on the specialized pattern-matching device;
generating, by the at least one processor, a pseudo-random bit stream;
transmitting, by the at least one processor to the specialized pattern-matching device, the pseudo-random bit stream for processing by the digitized finite state machine; and
receiving, by the at least one processor from the specialized pattern-matching device, pseudo-random output from the digitized finite state machine based on the pseudo-random bit stream input to the digitized finite state machine.

US Pat. No. 9,275,630

ULTRASOUND IMAGING BEAM-FORMER APPARATUS AND METHOD

University of Virginia Pa...

1. An apparatus, comprising:
a transducer array, comprising a plurality of transducers, each configured to convert reflected ultrasound pulses to at least
one incoming signal, wherein each of the at least one incoming signals has a period and an amplitude;

a signal receiver comprising:
a first sample-and-hold circuit configured to sample a first amplitude of the at least one incoming signal from a transducer
at a first specified instant, the first sample-and-hold circuit configured to acquire at most one amplitude sample per an
ultrasound transmit pulse/receive acquisition cycle, the first sample representing an in-phase amplitude;

a separate second sample-and-hold circuit configured to sample a second amplitude of the at least one incoming signal from
the transducer at a second specified instant, the second specified instant offset in time from the first specified instant
by an amount less than about half the period of the incoming signal, the second sample-and-hold circuit configured to acquire
at most one amplitude sample per the ultrasound transmit pulse/receive acquisition cycle, the second sample representing a
quadrature amplitude;

at least one analog-to-digital converter configured to convert the sampled amplitudes to digital values after both of the
first and second sample-and-hold circuits have completed sampling; and

a focusing apparatus configured to combine the digital values and to generate at least one image point.

US Pat. No. 9,468,396

SYSTEMS AND METHODS FOR DETERMINING LOCATION OF AN ACCESS NEEDLE IN A SUBJECT

UNIVERSITY OF VIRGINIA PA...

1. A system for accessing one or more locations of a subject, said device comprising:
a needle having a distal end and a proximal end;
a first sensor in communication with said needle for sensing pressure frequency in the one or more locations of the subject;
a medical device configured to be inserted in the aperture of the needle; and
a processor configured to:
receive pressure frequency information from the first sensor; and
distinguish a current location of the needle from another location based on an algorithm including the pressure frequency
information.

US Pat. No. 9,333,193

COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS

UNIVERSITY OF VIRGINIA PA...

1. A method of treating a mycobacterium infection, said method comprising administering to a subject in need thereof a pharmaceutical composition comprising a pharmaceutically-acceptable
carrier and an effective amount of a compound selected from the group consisting of:

and optionally an additional therapeutic agent thereby treating a mycobacterium infection.

US Pat. No. 9,561,266

TARGET PEPTIDES FOR IMMUNOTHERAPY AND DIAGNOSTICS

University of Virginia Pa...

1. A composition comprising:
(a) at least one synthetic target peptide, wherein each synthetic target peptide:
(i) is between 8 and 50 amino acids long, and
(ii) comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 2164-2167 and 2374; and
(b) a therapeutically effective amount of an adjuvant.

US Pat. No. 10,100,022

SPHINGOSINE KINASE INHIBITORS

University of Virginia Pa...

1. A compound of formula (IA)whereinX is phenyl;
R1 and R2 are independently selected from the group consisting of H, OH, —(C1-C6)alkyl-OH, halo, NH2, NOH, NHOH, and CN;
or R1 and R2, if bound to adjacent carbon atoms, in combination with the existing carbon-carbon bond represent a double bond between the adjacent carbon atoms;
R3 is selected from the group consisting of (C1-C6)alkyl, (C3-C8)cycloalkyl, (C1-C6)haloalkyl, CN, and halo;
R4 is selected from the group consisting of H, (C1-C6)alkyl, (C3-C8)cycloalkyl, (C1-C6)haloalkyl, CN, and halo,
wherein one of R3 and R4 —CF3;
m=0 or 1;
W is CH2, O or, NH;
V is selected from the group consisting of H, (C1-C10)alkyl, (C2-C12)alkenyl, —(C1-C10)alkyl-(C6-C10)aryl, —(C2-C12)alkenyl-(C6-C10)aryl, —(C1-C10)alkyl-(C6-C10)aryl-(C1-C10)alkyl, —(C1-C10)alkyl-(C3-C8)cycloalkyl, and —(C1-C10)alkyl-heterocyclyl containing from 1 to 3 ring heteroatoms selected from N, O, and S;
wherein any aryl is optionally fused to (C6-C10)aryl, (C3-C8)cycloalkyl, or heterocyclyl containing from 1 to 3 ring heteroatoms selected from N, O, and S
wherein any alkyl, alkenyl, cycloalkyl, heterocyclyl, or aryl is optionally substituted by 1-4 substituents independently selected from the group consisting of F, Cl, Br, (C1-C6)alkyl, —O—(C1-C6)alkyl, (C2-C6)alkenyl, (C1-C6)haloalkyl, and CN;
Y1, Y2, and Y3 are independently selected from the group consisting of C, N, NH, O, and S;or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,301,683

INTUITIVE TECHNIQUES AND APPARATUS FOR OPHTHALMIC IMAGING

University of Virginia Pa...

1. An optical apparatus, comprising:
an optical lens system configured to relay an image of an anatomical target to an image acquisition assembly via an optical
imaging path provided by the optical lens system, the optical lens system including:

an objective lens configured to be located near the anatomical target; and
an alignment assembly configured to be user-positionable at least partially in the optical imaging path;
a laser module configured to generate a collimated beam;
a diffractive element configured to receive the collimated beam and, in response, to provide a modified beam comprising a
focusing target; and

a beam splitter located along the optical imaging path, the beam splitter configured to direct at least a portion of the of
the modified beam comprising the focusing target to the anatomical target via at least a portion of the optical imaging path
including the objective lens;

wherein an image presented via the optical imaging path includes a first field of view to provide an image of an anatomical
landmark when the alignment assembly is included at least partially in the optical imaging path, and a second field of view
to provide the image of the anatomical target when the alignment assembly is substantially excluded from the optical imaging
path; and

wherein the focusing target is produced and is presented to the image acquisition assembly without use of a prismatic focusing
aid.

US Pat. No. 9,171,707

REAGENTS FOR ELECTRON TRANSFER DISSOCIATION IN MASS SPECTROMETRY ANALYSIS

University of Virginia Pa...

1. A method of mass spectrometry analysis based on electron transfer dissociation (ETD) of multiply charged organic and/or
biomolecular cations, the method comprising the steps of
(a) introducing the multiply charged cations into an RF electric field ion containment device of a mass spectrometer; and
introducing polycyclic aromatic hydrocarbon anions as gas-phase electron transfer reagents into the ion containment device,
wherein the polycyclic aromatic hydrocarbon anions are anions of polycyclic aromatic hydrocarbons selected from the set consisting
of azulene, homoazulene, acenaphthylene, a homodimer of any of azulene, homoazulene, or acenaphthylene, and a heterodimer
comprising one each of azulene, homoazulene, or acenaphthylene; or any mixture thereof; and then

(b) mixing the introduced polycyclic aromatic hydrocarbon anions or derivative anions thereof, and the multiply charged cations
or derivative multiply charged cations thereof, wherein the derivative anions and the derivative multiply charged cations
are generated within the ion containment device during performance of the method, for electron transfer from the polycyclic
aromatic hydrocarbon anions or the derivative anions thereof to the multiply charged cations or the derivative multiply charged
cations thereof, to induce cleavage of covalent bonds and produce fragment and/or dissociation product cations; and mass (m/z)
analyzing and detecting said fragment and/or dissociation product cations or cations derived from the fragment and/or dissociation
product cations for mass spectrometric analysis.

US Pat. No. 9,044,735

DNA EXTRACTION USING A PHOTO-POLYMERIZED MONOLITH IN A CAPILLARY

University of Virginia Pa...

1. A method for preparing a monolithic column comprising the steps of:
(i) providing a vessel;
(ii) conditioning the interior surface of said vessel by contacting it with a silica-based flushing solution;
(iii) preparing a silica-based monomer solution through hydrolysis of a silica monomer;
(iv) forming a polymerizable mixture by admixing said silica-based monomer solution, an initiator material, and a porogenic
solvent;

(v) introducing said polymerizable mixture into the vessel;
(vi) initiating the in situ polymerization of said polymerizable mixture by exposing selected portions of the mixture to UV
light, thereby forming the UV photo-polymerized silica-based monolithic column within portions of the vessel;

(vii) flushing a silica-based monomer reagent through said UV photo-polymerized silica-based monolithic column, thereby forming
the grafted porous UV photo-polymerized silica-based monolithic column within portions of the vessel.

US Pat. No. 9,882,428

ENERGY HARVESTING AND CONTROL FOR SENSOR NODE

UNIVERSITY OF VIRGINIA PA...

1. A sensor node, comprising:
a regulator circuit including an input coupleable to an energy harvesting transducer;
a wireless receiver circuit coupled to the regulator circuit and configured to wirelessly receive at least enough operating
energy to establish operation of the sensor node without requiring the energy harvesting transducer;

a digital processor circuit coupled to the regulator circuit; and
a power management processor circuit configured to select an energy consumption level of the sensor node based on an input
to the regulator circuit;

wherein the digital processor circuit includes a subthreshold operational mode established by the power management processor
circuit based on the selected energy consumption level; and

wherein establishing the subthreshold operational mode includes adjusting or selecting a supply voltage provided by the regulator
circuit so as to establish subthreshold operation of a field effect transistor (FET) in the digital processor circuit.

US Pat. No. 9,656,261

DNA ANALYZER

LEIDOS INNOVATIONS TECHNO...

1. A microfluidic chip, comprising:
an inlet configured to receive a template DNA extracted from a sample acceptor that is external of the microfluidic chip and
is fluidically coupled to the microfluidic chip on a cartridge;

a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, the first domain including a
thermal-coupler reservoir coupled with a PCR reservoir for PCR amplification, thermal cycles in the PCR reservoir being induced
based on temperature measured from the thermal-coupler reservoir;

a dilution domain having a reservoir that is fluidically coupled to the first domain and is configured to dilute a PCR mixture
received from the first domain with a dilutant in the reservoir; and

a second domain that is fluidically coupled to the dilution domain so as to receive the amplified DNA fragments, the second
domain including a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments.

US Pat. No. 9,350,294

LOW VOLTAGE CRYSTAL OSCILLATOR (XTAL) DRIVER WITH FEEDBACK CONTROLLED DUTY CYCLING FOR ULTRA LOW POWER

UNIVERSITY OF VIRGINIA PA...

7. An apparatus, comprising:
a crystal oscillator (XTAL) configured to generate an oscillation;
a XTAL driver communicatively coupled to the XTAL, the XTAL driver configured to generate a duty cycle signal to modulate
an envelope of the oscillation; and

a feedback control unit communicatively coupled to the XTAL driver and the XTAL, the feedback control unit configured to generate
an adjustment signal to adjust effective lengths of metal-oxide-semiconductor (MOS) transistors of the XTAL driver, the feedback
control unit configured to use feedback from the oscillation to repeatedly turn on the XTAL driver when an amplitude of the
envelope of the oscillation decays to a minimum value and turn off the XTAL driver when the amplitude of the envelope of the
oscillation reaches a maximum value.

US Pat. No. 9,244,160

ULTRASONIC TRANSDUCER DRIVE

University of Virginia Pa...

1. An ultrasonic transducer drive, comprising:
a signal generator for producing an outgoing signal;
a transducer for converting said outgoing signal to outgoing ultrasound and for converting at least a portion of reflected
ultrasound to an incoming signal, said transducer having a transmit side and a receive side;

said transmit side connected conductably to said signal generator during a first predetermined period of time;
said receive side connected conductably to a signal receiver during a second predetermined period of time; and
a shunt connectable between said receive side and a first reference potential;
wherein said signal generator is configured to generate said outgoing signal during said first predetermined period of time
while said shunt is configured to connect said receive side to said first reference potential during said first predetermined
period of time;

wherein said signal receiver is configured to receive said incoming signal during said second predetermined period of time
while said shunt is configured to be open during said second predetermined period of time and while said transmit side is
configured to connect to a second reference potential during said second predetermined period of time;

wherein said receive side is connected operably to a receive switch;
wherein said receive switch is connectable switchably to said signal receiver; and
wherein said receive switch is configured to connect said receive side to said signal receiver for said second predetermined
period of time;

wherein said transmit side is connected operably to a transmit switch;
wherein said transmit switch is connectable switchably to said signal generator and to said second reference potential;
wherein said transmit switch is configured to connect said transmit side to said signal generator for said first predetermined
period of time and said transmit switch is configured to connect said transmit side to said second reference potential for
said second predetermined period of time;

wherein said reflected ultrasound is elicited by said outgoing ultrasound; and
wherein said receive side is conductively isolated from said transmit side.
US Pat. No. 9,233,127

COMPOSITIONS AND METHODS FOR CXCR4 SIGNALING AND UMBILICAL CORD BLOOD STEM CELL ENGRAFTMENT

University of Virginia Pa...

1. A method for enhancing hemopoietic cell engraftment in a subject in need thereof, said method comprising contacting a population
of cells comprising hemopoietic cells with an effective amount of at least one agent that enhances engraftment of said hemopoietic
cells and administering said population of cells to said subject, wherein said population of cells comprising hemopoietic
cells is selected from the group consisting of umbilical cord blood cells, peripheral blood cells, and bone marrow cells,
wherein at least one of said at least one agents is complement protein fragment 3a (C3a) or active fragments and homologs
thereof, further wherein two populations of umbilical cord blood cells are administered and each of said administered populations
comprises at least 1.5×107 nucleated cells/kg.

US Pat. No. 9,221,764

INHIBITORS OF INV(16) LEUKEMIA

University of Virginia Pa...

1. A method of treating inv(16) leukemia in a subject in need thereof, said method comprising administering to said subject
a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a therapeutically effective amount of a
compound of the formula:

wherein R1, R2, R3, R4, R5, and R6 are each independently selected from hydrogen, —OH, —COOH, —OCNH2, —OCH3, halogen, —OC2H5, —SCH3, —OCF3, —CF3,


 and
X is selected from the group consisting of

or a pharmaceutically-acceptable salt, enantiomer, or tautomer thereof.

US Pat. No. 9,812,965

LOW INPUT VOLTAGE BOOST CONVERTER WITH PEAK INDUCTOR CURRENT CONTROL AND OFFSET COMPENSATED ZERO DETECTION

University of Virginia Pa...

20. An apparatus, comprising:
an inductor configured to pass through an inductor current;
a boost converter switch operatively coupled to the inductor, configured to receive a control signal to activate a boost converter
to generate the inductor current; and

a switch control circuit operatively coupled to the boost converter switch, the switch control circuit configured to:
receive an input voltage and generate a control signal having an amplitude proportional to the square of a magnitude of the
input voltage and having a pulse duration proportional to an inverse of the magnitude of the input voltage, and

vary an activation time of the boost converter switch based on the input voltage to maintain a peak inductor current of the
inductor substantially constant.

US Pat. No. 9,526,922

SYSTEM FOR TREATMENT AND IMAGING USING ULTRASONIC ENERGY AND MICROBUBBLES AND RELATED METHOD THEREOF

University of Virginia Pa...

21. A method of providing therapy to a treatment site of a subject, said method comprising:
advancing an ultrasound catheter to or in proximity to the subject's treatment site, said catheter having a proximal region
and a distal region;

infusing microbubbles from said distal region of said ultrasound catheter into or proximal to the treatment site;
administering a thrombus lysing agent to the subject's treatment site;
delivering therapeutic ultrasonic energy from within said distal region of said ultrasound catheter to said microbubbles to
focally deliver said microbubbles to the treatment site; and

delivering imaging ultrasonic energy from within said distal region of said ultrasound catheter to the treatment site to provide
real time imaging of the treatment site;

wherein the microbubbles are infused directionally toward a location from which said therapeutic ultrasonic energy is directed.
US Pat. No. 9,415,058

UNIT DOSAGE OF APADENOSON

University of Virginia Pa...

1. A method of chemically inducing stress and diagnosing myocardial perfusion abnormalities in a mammal, comprising:
(a) selecting a dose of Apadenoson between about 100-175 ?g on a basis that is independent of the weight of the mammal to
whom the dose will be administered;

(b) administering to said mammal, via bolus, the dose of Apadenoson as a unit dose comprising Apadenson and a pharmaceutically
acceptable carrier; and

(c) performing a technique to detect the presence of coronary artery stenoses in the mammal, to assess the severity of coronary
artery stenoses in the mammal, or a combination thereof, so as to diagnose myocardial perfusion abnormalities in said mammal.

US Pat. No. 9,322,896

SYSTEMS AND METHODS FOR REDUCED OFF-RESONANCE BLURRING IN SPIRAL IMAGING

University of Virginia Pa...

1. A method, comprising:
acquiring magnetic resonance imaging (MRI) data associated with an area of interest of a subject, comprising:
acquiring a first set of spiral interleaf data for each of one or more spiral-in/out interleaves by performing a first sampling
of each of one or more locations in k-space along a first redundant spiral-in/out trajectory,

acquiring a second set of spiral interleaf data for each of the one or more spiral-in/out interleaves by performing a second
sampling of each of the one or more locations in the k-space along a second redundant spiral-in/out trajectory,

wherein the second redundant spiral-in/out trajectory corresponds to a time-reversed trajectory of the first redundant spiral-in/out
trajectory, and

combining the first set of spiral interleaf data and the second set of spiral interleaf data with an averaging operation such
as to reduce artifacts.

US Pat. No. 9,064,321

IMAGING OR COMMUNICATIONS SYSTEM UTILIZING MULTISAMPLE APODIZATION AND METHOD

University of Virginia Pa...

1. A method for enhancing contrast resolution of an imaging or sensing system, comprising:
receiving information from an array of transducers using multiple data channels;
digitally filtering the received information on the multiple data channels using respective finite impulse response (FIR)
filters corresponding to respective data channels, the FIR filters having multiple taps, the taps including tap weights determined
(1) as a function of a distance of the array from an object that energy is being transmitted to or reflected from, and (2)
corresponding to an a priori system model; and

aggregating outputs of the finite impulse response filters to provide a sample.

US Pat. No. 9,051,630

AMORPHOUS STEEL COMPOSITES WITH ENHANCED STRENGTHS, ELASTIC PROPERTIES AND DUCTILITIES

University of Virginia Pa...

17. An amorphous steel composite comprised substantially of a composition represented by the formula:
[Fe1-a-b-c-d-e-fMnaCrbMoc(Ln1-xYx)dCeBf]100-?[CER]?,

wherein Ln represents an element in the Lanthanide series; and
wherein CER represents a ceramic consisting of one of three types:
i) a carbide or nitride comprised substantially of a composition represented by the formula: M0.5-yM?yC0.5-zNz
wherein M and M? represent one or two group IV or V refractory metals, and
wherein y and z satisfy the relations 0.5?y?0 and 0.5?z?0;
ii) an iron-refractory carbide comprised substantially of a composition represented by the formula: Fe1-y-zMyCz
wherein M represents a refractory or reactive metal, and
wherein y and z satisfy the relations 1.0?y>0 and 1.0?z>0; or
iii) an iron-refractory boride comprised substantially of a composition represented by the formula: Fe1-y-zMyBz
wherein M represents a refractory or reactive metal, and
wherein y and z satisfy the relations 1.0?y>0 and 1.0?z>0; and
wherein a, b, c, d, e, f, x, and a satisfy the relations:
0.05?a?0, 0.15?b?0.01, 0.16?c?0.10, 0.03?d?0.015, 0.16?e?0.14, 0.07?f?0.05, 1.0x?0, 10??>4,
wherein said composite is a bulk amorphous sample of at least about 2 mm in thickness in its minimum dimension,
wherein said composite has a shear modulus of at least about 85 GPa.

US Pat. No. 10,028,682

OXIDATION MEASUREMENT SYSTEM AND RELATED METHOD THEREOF

University of Virginia Pa...

43. A catheter system for measuring the oxidation state of biological molecules in a region of a measurement site of a subject, said system comprising:a catheter device having a lumen, said catheter device includes proximal region, a distal region, and a longitudinal region there between;
at least one emitter in mechanical communication with said catheter distal region and configured to make contact with a tissue wall of the subject;
at least one detector in mechanical communication with said catheter distal region and configured to make contact with the tissue wall of the subject;
an expandable component in mechanical communication with said catheter distal region, and said expandable component is located between said at least one emitter and said at least one detector and said catheter distal region;
wherein said expandable component is configured to assure that said at least one emitter and said at least one detector makes contact with the tissue wall;
said at least one emitter and said at least one detector are in electromagnetic radiation communication with one another, wherein the electromagnetic radiation communication allows visible radiation or near infrared radiation emitted by said at least one emitter to be detected by said at least one detector to determine tissue oxidation state of the region of the measurement site of the subject; and
a processor configured to perform algorithmic steps to determine the tissue oxygenation (StO2) of the region of the subject from detector data.

US Pat. No. 9,669,198

SYSTEM AND METHOD FOR INTRACRANIAL IMPLANTATION OF THERAPEUTIC OR DIAGNOSTIC AGENTS

University of Virginia Pa...

1. A system for intracranial delivery of a diagnostic or therapeutic solid agent to the brain of a subject, said system comprising:
an insertion device for delivery of the diagnostic or therapeutic solid agent to the brain, said insertion device being configured
to retain the diagnostic or therapeutic solid agent to the insertion device and to release the diagnostic or therapeutic solid
agent from the insertion device; and

an interface member configured to be attached to the subject's skull, said interface member being further configured to hold
said insertion device at a predetermined alignment angle with respect to the subject's skull,

wherein said insertion device comprises a sleeve configured to hold the diagnostic or therapeutic solid agent, an obturator
sized to fit in said sleeve, and a first locking mechanism configured to releasably couple said sleeve and said obturator
to move together as an assembly,

wherein said interface member comprises a second locking mechanism configured to secure said obturator from moving relative
to said interface member while allowing said sleeve to be withdrawn relative to said obturator, and

the diagnostic or therapeutic solid agent has an outer diameter substantially corresponding to an inner diameter of the sleeve.

US Pat. No. 9,325,240

LOW INPUT VOLTAGE BOOST CONVERTER WITH PEAK INDUCTOR CURRENT CONTROL AND OFFSET COMPENSATED ZERO DETECTION

UNIVERSITY OF VIRGINIA PA...

1. An apparatus, comprising:
an inductor configured to pass through an inductor current;
a boost converter switch operatively coupled to the inductor, the boost converter switch configured to receive an input voltage
and generate an output voltage when the boost converter switch is activated; and

a switch control circuit operatively coupled to the boost converter switch, the switch control circuit configured to sample
and measure the input voltage, the switch control circuit configured to determine a pulse duration of a control signal, the
pulse duration being proportional to an inverse of the input voltage, the switch control circuit configured to send the control
signal to activate the boost converter switch so as to maintain a peak inductor current substantially constant, the peak inductor
current being first-order independent of the input voltage and the output voltage.

US Pat. No. 9,279,011

PHOSPHOPEPTIDES AS MELANOMA VACCINES

The Johns Hopkins Univers...

1. A composition comprising: an isolated phosphopeptide consisting of between 9 and 30 contiguous amino acids selected from
SEQ ID NO:1 (MART-1) including motif YEKLSA (residues 104-109 of SEQ ID NO: 1) containing the serine at position 108 of MART-1,
wherein the serine is phosphorylated, wherein the phosphopeptide binds to HLA-DR1; and
an effective amount of an immune adjuvant.
US Pat. No. 9,345,755

COMPOSITION AND METHODS FOR TREATING MELANOMA

University of Virginia Pa...

1. A composition comprising at least one isolated or synthetic peptide selected from the group consisting of peptides SEQ
ID NOs: 1-8, optionally an adjuvant, and optionally a pharmaceutically acceptable carrier.

US Pat. No. 9,192,408

ACCESS TROCAR AND RELATED METHOD THEREOF

University of Virginia Pa...

1. A method for accessing a subject's anatomical space having a surface, the method comprising:
providing a first elongated member comprising a proximal end and a distal end, said distal end comprising a sharp end;
providing a second elongated member comprising a proximal end, a distal end, a first middle portion adjacent to said distal
end, and a second middle portion adjacent to said proximal end, said second middle portion of said second elongated member
including a helical groove, and said distal end comprising a helical tine engaging said surface with said helical tine;

providing a third elongated member comprising a longitudinal aperture, a distal end, a middle portion, and a proximal end,
wherein said third elongated member at least substantially encloses said first elongated member and said second elongated
member;

providing a driving mechanism including a driver tab, said driver tab adapted to pass through said longitudinal aperture of
said third elongated member and engage said helical groove of said second elongated member;

driving the second elongated member in a distal direction by moving the driver tab distally;
driving the second elongated member in a proximal direction by moving the driver tab proximally; and
turning said helical tine to cause lifting of said surface in a proximal direction, whereby the lifting assists in advancing
said surface in contact with said sharp end to cause an incision of the surface by said sharp end.

US Pat. No. 9,074,129

MECHANOCHROMIC LUMINESCENT DIFLUOROBORON BETA-DIKETONATES

University of Virginia Pa...

1. A composition comprising a mechanochromic luminescent solid-state form of a difluoroboron ?-diketonate of formula

US Pat. No. 9,046,462

CHIRPED PULSE FREQUENCY-DOMAIN COMB FOR SPECTROSCOPY

University of Virginia Pa...

1. A method, comprising:
generating a pulse train comprising chirped pulses of electromagnetic energy, the respective chirped pulses including a frequency
sweep across a first specified bandwidth during a respective chirped pulse duration, the respective chirped pulse duration
establishing a first frequency-domain comb peak separation; and

exciting a sample using the pulse train;
wherein a width of a frequency-domain comb peak is established at least in part by a total duration of the pulse train; and
wherein a bandwidth of a first frequency-domain comb is determined at least in part by the first specified bandwidth of the
frequency sweep of the respective chirped pulses.

US Pat. No. 9,882,660

METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR REAL-TIME DETECTION OF SENSITIVITY DECLINE IN ANALYTE SENSORS

ABBOTT DIABETES CARE INC....

1. A system for detecting signal attenuation comprising:
an analyte sensor for positioning under a skin surface in fluid contact with bodily fluid; and
a data processing device comprising a memory, wherein the data processing device is operatively coupled to the analyte sensor,
the data processing device configured to receive a first plurality of analyte sensor related signals from the analyte sensor
within a first predetermined time period determined within the first 24 hours of analyte sensor positioning under the skin surface,

wherein a computer program is stored on the memory such that, when executed, the computer program causes the data processing
device:

to determine a probability of signal attenuation associated with the analyte sensor based at least in part on the first plurality
of analyte sensor related signals,

to determine a sensitivity of the analyte sensor based on a second plurality of analyte sensor related signals from the analyte
sensor and a reference analyte measurement, the reference analyte measurement comprising a finger stick measurement of a blood
analyte level,

to determine a sensitivity ratio based on the determined sensitivity of the analyte sensor divided by a nominal sensitivity
determined prior to analyte sensor positioning, the nominal sensitivity comprising a sensitivity value of the analyte sensor
at the time of manufacture, and

to verify a presence of signal attenuation associated with a decline in analyte sensor sensitivity when the determined sensitivity
ratio is less than a first predetermined signal attenuation threshold level.

US Pat. No. 9,745,736

THREE-DIMENSIONAL SPACE FRAMES ASSEMBLED FROM COMPONENT PIECES AND METHODS FOR MAKING THE SAME

University of Virginia Pa...

1. A method for producing a space frame, said method comprising:
providing a plurality of first members comprising alternating linear struts with inflection areas between said alternating
linear struts, said first members having an anterior surface and a posterior surface, a recess at each said inflection area
of said first members to define an inflection recess, all of said inflection recesses disposed along said anterior surface
of said first member;

arranging said plurality of said first members into an array with a first portion of said plurality of said first members
arrayed substantially parallel to one another; and arranging a second portion of said plurality of said first members arrayed
substantially orthogonal to said arrayed first portion of said plurality of said first members, so as to define an intersecting
array structure;

wherein said first portion of said plurality of said first members is inverted with respect to said second portion of said
plurality of said first members so that said anterior surfaces of said first portion of said plurality of said first members
are in communication with said anterior surfaces of said second portion of said plurality of said first members;

said first portion of said plurality of said first members and said second portion of said plurality of said first members
aligned so that said inflection recesses of said inflection areas of said first portion of said plurality of said first members
are in communication with said inflection recesses of said inflection areas of said second portion of said plurality of said
first members to define a tenon or tenon-like structure;

providing a lattice shape member comprising struts disposed between nodes, each of said nodes having a mortise recess configured
to interface with said tenon or tenon-like structures, said struts configured such that said nodes are located such that said
mortise recesses are properly spaced so as to communicate with said tenons or tenon-like structures from the array comprised
of said plurality of said first members; and

disposing said lattice shape member such that said mortise recess of said nodes are in communication with said tenons or tenon-like
structures to provide said space frame.

US Pat. No. 9,589,345

SYSTEMS AND METHODS FOR ACCELERATED ARTERIAL SPIN LABELING USING COMPRESSED SENSING

University of Virginia Pa...

1. A method comprising:
acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds
to at least one physiological activity of the subject and the acquiring comprises receiving data associated with arterial
spin labeling (ASL) of the area of interest of the subject;

performing image reconstruction, comprising compressed sensing reconstruction, on at least a portion of the acquired magnetic
resonance data; and

determining at least one characteristic of the physiological activity in the area of interest of the subject based on the
acquired magnetic resonance data.

US Pat. No. 9,579,120

ULTRASOUND FOR LOCATING ANATOMY OR PROBE GUIDANCE

University of Virginia Pa...

1. A hand-held apparatus, comprising:
a hand-held housing having a planar surface;
a probe guide configured to provide a specified path for guiding travel by a probe, the guide extending along a central axis
from an entry port to an exit port, the entry port configured for insertion of the probe into the probe guide by a user, the
exit port configured to provide an insertion location for the probe in a subject, the exit port disposed proximal to the planar
surface;

a piezoelectric element disposed proximal to the probe guide and configured to measure an angle of the central axis of the
probe guide;

one or more ultrasonic transducers located on or within the hand-held housing and configured to generate ultrasonic energy
directed into tissue of the subject at an angle parallel to the central axis of the probe guide, and configured to receive
ultrasonic energy reflected by a target, including underlying bone and an access site adjacent to the underlying bone;

a motion tracking circuit included in the housing and configured to provide information indicative of a motion of the hand-held
apparatus when the hand-held apparatus is mechanically scanned by the user;

a processor circuit configured to:
determine information about a relative location of the underlying bone and the access site with respect to a portion of the
hand-held apparatus using the received ultrasonic energy and the information indicative of the motion of the hand-held apparatus;
and

calculate the angle of the probe guide from an output of the piezoelectric element; and
a display mounted on or within the housing and configured to receive and display the determined information from the processor
circuit; wherein

the information about the relative location of the underlying bone with respect to the portion hand-held apparatus includes
information about a relative surface position of the underlying bone with respect to the portion of the hand-held apparatus
and information about a relative orientation of the underlying bone with respect to the portion of the hand-held apparatus;
and wherein

the probe guide includes a mechanical actuator configured to automatically adjust the angle of the probe guide according to
the calculated angle and the determined information.

US Pat. No. 9,430,022

METHOD AND APPARATUS FOR MODULAR POWER MANAGEMENT AND PROTECTION OF CRITICAL SERVICES IN AMBULATORY MEDICAL DEVICES

University of Virginia Pa...

1. A computer-implemented method for managing power consumption of a battery-operated device configured to provide a plurality
of services, comprising, performing by a processor:
receiving a battery level of said device, at least one parameter of a user of the device, and the services being provided
by the device, constructing time profiles encoding a probability of at least one of said battery level, user parameter, and
services being provided having certain values at each of a number of time segments k;

setting a fidelity policy u(k) for each time segment k, said fidelity policy defining a level of fidelity for each service,
based on said time profiles and battery level;

computing, based on said time profiles, an amount of time remaining before battery exhaustion under said battery level and
a mode of operation having a predefine power consumption rate, and taking a predetermined action based on the computed amount
of time remaining with respect to at least one preset threshold; and

regulating access of said services to resources of said device for performing said services, in accordance with said predetermined
action.

US Pat. No. 9,811,924

INTERFEROMETRIC TECHNIQUES FOR MAGNETIC RESONANCE IMAGING

University of Virginia Pa...

1. A method for reconstructing a spectroscopic image of an object, the method comprising:
(a) taking magnetic resonance imaging data of the object;
(b) temporally cross-correlating multiple k-space locations of said data to map a new correlation domain, the new correlation
domain representative of a Fourier transform of a function defining a spectroscopic image, squared; and

(c) forming the spectroscopic image using said new correlation domain as a representation for transmission to an output module
or display module or combination thereof, the forming including performing an inverse transform on the new correlation domain.

US Pat. No. 9,801,540

SELF-ILLUMINATED HANDHELD LENS FOR RETINAL EXAMINATION AND PHOTOGRAPHY AND RELATED METHOD THEREOF

University of Virginia Pa...

1. A self-illuminated handheld lens for wide angle retinal viewing of a subject eye, comprising:
an aspherical objective lens having a symmetric viewing axis and defining a viewing channel;
a contact lens positioned in front of said aspherical objective lens to be applied to said subject eye;
plurality of LEDs positioned around said viewing axis and configured to illuminate said subject eye outside from said viewing
channel;

a light baffle configured to block stray light of said LEDs from getting into said viewing channel; and
cross polarization means incorporated between said plurality of LEDs and said viewing channel of said aspherical objective
lens, wherein said cross polarization means comprises a first polarizer attached to cover said LEDs and a second polarizer
positioned in said viewing channel of said aspherical objective lens.

US Pat. No. 9,590,638

LOW POWER CLOCK SOURCE

University of Virginia Pa...

1. An apparatus, comprising:
a first oscillator circuit including a first oscillator output;
a second oscillator circuit including a configuration input and a second oscillator output; and
a comparator circuit including first and second comparator inputs respectively controllably coupleable to the first and second
oscillator outputs;

wherein a first oscillator output signal from the first oscillator output deviates from a specified output period by a first
output deviation and a second oscillator output signal from the second oscillator output deviates from the specified output
period by a second output deviation, the first output deviation being less than the second output deviation; and

wherein the second oscillator circuit is configured to adjust, using the configuration input, the second oscillator output
signal based on information obtained from the comparator circuit about a comparison between the first oscillator output signal
and the second oscillator output signal so as to reduce a difference between the first output deviation and the second output
deviation.

US Pat. No. 9,550,864

VISCOELASTIC SILICON RUBBER COMPOSITIONS

UNIVERSITY OF VIRGINIA PA...

1. A viscoelastic silicone rubber composition comprising:
(a) at least one polyorganosiloxane;
(b) at least one permanent crosslinking agent present in an amount to provide sufficient permanent crosslinks to give the
composition an equilibrium shape when cured;

(c) at least one temporary crosslinking agent present in an amount to provide sufficient temporary crosslinks to give the
composition a stiffness when cured that is greater on short timescales than it is on long timescales; and

(d) at least one softening agent present in an amount sufficient to make the average lifetime of the temporary crosslink of
shorter duration than the average lifetime of the temporary crosslink in the absence of the softening agent.

US Pat. No. 9,490,698

LOW INPUT VOLTAGE BOOST CONVERTER WITH PEAK INDUCTOR CURRENT CONTROL AND OFFSET COMPENSATED ZERO DETECTION

UNIVERSITY OF VIRGINIA PA...

1. A method, comprising:
receiving an input voltage;
generating two non-overlapping clock phase signals including a first clock phase signal and a second clock phase signal;
operating a boost converter to generate an output voltage according to the first clock phase signal while maintaining a peak
inductor current for an inductor substantially constant, the peak inductor current being first-order independent of the input
voltage and the output voltage; and

performing offset cancellation to remove offset at a comparator of the boost converter according to the second clock phase
signal.

US Pat. No. 9,357,920

HAND-HELD PORTABLE FUNDUS CAMERA FOR SCREENING PHOTOGRAPHY

University of Virginia Pa...

1. A hand-held portable fundus camera system comprising:
a module optical system capable of being integrated with a consumer camera device for auto focus photography by said consumer
camera device of the fundus of an eye;

said module optical system, comprising:
a composing image acquisition illumination observation source;
a final image acquisition illumination source;
an optical separator and transmitter for separating and transmitting said composing image acquisition observation illumination
source and said final image acquisition illumination source to an image mask, each of which is relayed to the retina of the
fundus through the use of a rear converging lens, redirecting mirror, a beam splitter and a front objective lens;

said image mask configured to provide light that illuminates the retina to output an image that is relayed through said objective
lens and captured by said consumer camera to provide an image of the retina;

a module interface system to integrate said module optical system with said consumer camera device;
wherein said module interface system enhances the macro focusing capability of said consumer camera device to enable auto-focus
photography by said consumer camera device of the fundus image produced by said front objective lens.

US Pat. No. 9,218,752

SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR SIMULATING EPICARDIAL ELECTROPHYSIOLOGY PROCEDURES

UNIVERSITY OF VIRGINIA PA...

1. An in vitro model system, said system comprising:
a thoracic cavity;
lungs disposed within said thoracic cavity;
said lungs configured to contain a lung fluid having a lung pressure-frequency profile;
a heart disposed within said thoracic cavity;
said heart configured to contain a cardiac fluid having a cardiac pressure frequency profile; and
a pericardium disposed within said thoracic cavity and configured to at least partially surround said heart;
said pericardium configured to contain—between said pericardium and said heart—a pericardial fluid having a pericardial pressure-frequency
profile.

US Pat. No. 9,606,123

COMPOSITIONS AND METHODS FOR DIAGNOSING AND MONITORING OVARIAN CANCER PROGRESSION AND TREATMENT

University of Virginia Pa...

1. A method for differentiating platinum-sensitive metastatic ovarian cancer from platinum-resistant metastatic ovarian cancer,
said method comprising administering an effective amount of a platinum-based chemotherapeutic agent to a subject with ovarian
cancer, determining the level of VCAM-1 expression in said subject following said administration and comparing said VCAM-1
level to the level of VCAM-1 expression in said subject prior to administration of said chemotherapeutic agent or to a standard
value of VCAM-1 levels, wherein said VCAM-1 levels in said subject are determined by administering to said subject an effective
amount of a VCAM-1 imaging probe that binds to VCAM-1 or contacting a biopsy from said subject with an effective amount of
a VCAM-1 imaging probe, and then determining the amount of VCAM-1 levels in said subject or in said biopsy, wherein said VCAM-1
probe is a multimeric peptide ligand complex comprising SEQ ID NO:1, each of said peptides is coupled to polyethylene glycol,
said polyethylene glycol is coupled to a chelating agent via a linking agent, and optionally at least one imaging agent is
coupled to said chelating agent, wherein a decrease in VCAM-1 levels following said administration is an indication that the
ovarian cancer is platinum-sensitive and no change in VCAM-1 levels is an indication that the ovarian cancer is platinum-resistant,
thereby differentiating platinum-sensitive metastatic ovarian cancer from platinum-resistant metastatic ovarian cancer.

US Pat. No. 9,570,559

GRAPHENE DEVICE INCLUDING ANGULAR SPLIT GATE

University of Virginia Pa...

1. An electronic device, comprising:
a dielectric layer;
a graphene layer including a first surface located upon the dielectric layer; and
a first electrode, a second electrode, and a third electrode each separated from the graphene layer by the dielectric layer;
wherein the first and second electrodes are spaced apart along the dielectric layer to define a first gap between the first
and second electrodes;

wherein the second and third electrodes are spaced apart along the dielectric layer to define a second gap between the second
and third electrodes;

wherein the sidewalls of the first and second electrodes defining the first gap are perpendicular with respect to a longitudinal
axis of the electronic device and the sidewalls of the second and third electrodes defining the second gap are angled with
respect to the longitudinal axis of the electronic device;

wherein the graphene layer includes a second surface opposite the first surface; and
wherein the electronic device includes:
a fourth electrode located upon the second surface of the graphene layer at a location along the longitudinal axis of the
electronic device; and

a fifth electrode located upon the second surface of the graphene layer at a location along the longitudinal axis of the electronic
device.

US Pat. No. 9,278,098

SUBSTITUTED PHTHALAZINES FOR INDUCING INSULIN SECRETION AND PROTECTING BETA-CELLS

UNIVERSITY OF VIRGINIA PA...

1. A method for protecting ?-cells in a mammal against apoptosis comprising administering to said mammal an effective amount
of a compound having formula III:

wherein:
(i) R3a is hydrogen and R3b is selected from C5-22alkyl, C2-22alkenyl, or C2-22alkynyl; or

(ii) R3b is hydrogen and R3a is selected from C9alkyl, C15-22alkyl, C9-22alkenyl, or C2-22alkynyl; or

(iii) R3a and R3b are the same or different and are selected from C9alkyl, C15-22alkyl, C4-22alkenyl, or C2-22alkynyl; or

a pharmaceutically acceptable salt thereof.

US Pat. No. 9,224,210

SYSTEMS AND METHODS FOR ACCELERATED DYNAMIC MAGNETIC RESONANCE IMAGING

University of Virginia Pa...

1. A method for motion-compensation and regional sparsity in accelerated magnetic resonance imaging (MRI), comprising:
(a) acquiring undersampled MRI data corresponding to a set of consecutive dynamic images associated with an area of interest
of a subject;

(b) defining the set of consecutive dynamic images as an initial set of estimated images;
(c) separating an image of the initial set of estimated images into a plurality of image regions;
(d) performing motion tracking for each image region of the plurality of image regions, throughout the initial set of estimated
images, based at least in part on motion data associated with motion of the subject;

(e) grouping the motion-tracked image regions into a plurality of clusters, based at least in part on spatial contents;
(f) applying a sparsity transform to the plurality of clusters to form a plurality of sparsity-exploited, transformed image
regions;

(g) forming a set of merged images from the plurality of sparsity-exploited, transformed image regions; and
(h) updating the set of merged images based on data fidelity, to form an updated set of estimated images.
US Pat. No. 9,890,407

METHOD FOR SYNTHESIZING CELLULOSE IN VITRO

University of Virginia Pa...

1. A method for synthesizing cellulose In vitro using purified bacterial components, said method comprising adding purified
bacterial cellulose synthase A (BcsA), or a biologically active fragment or homolog thereof, and purified bacterial cellulose
synthase B (BcsB), or a biologically active fragment or homolog thereof, to a mixture of uridine diphosphate glucose (UDP-Glc)
without lipid linked intermediates, a divalent cation, dimeric guanosine monophosphate (c-di-GMP) when the BcsA or a biologically
active fragment or homolog thereof is not constitutively active, a membrane mimetic, and a physiologic buffer to form a mixture,
wherein said BcsA and said BcsB are purified as a complex or said BcsA and said BcsB are purified separately, wherein said
membrane mimetic is selected from the group consisting of a detergent micelle, lipid vesicle, and planar lipid bilayer, thereby
synthesizing cellulose.

US Pat. No. 9,845,465

COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL ARTERIAL DISEASE

University of Virginia Pa...

1. A method of treating or preventing a disease, disorder, injury, or condition associated with skeletal muscle ischemia,
wherein said disease, disorder, injury, or condition is peripheral arterial disease, said method comprising administering
to a subject a pharmaceutical composition comprising an effective amount of an agonist of miRNA expression, levels, or activity,
a pharmaceutically-acceptable carrier, wherein said miRNA is miR-93, and optionally an additional therapeutic agent, thereby
treating said disease, disorder, or condition associated with ischemia.
US Pat. No. 9,623,128

COMPOSITIONS AND METHODS FOR DETECTING PLECTIN-1 AS A BIOMARKER FOR CANCER

University of Virginia Pa...

1. A method for detecting cancer, diagnosing cancer, monitoring the progression of cancer, or monitoring treatment of a cancer,
wherein cells of said cancer express Plectin-1 or a homolog or fragment thereof, said method comprising administering to a
test subject a pharmaceutical composition comprising a tetrameric peptide ligand complex, wherein said tetrameric peptide
ligand complex comprises an imaging agent, wherein said tetrameric peptide ligand complex has the formula (?AKTLLPTPGGS (SEQ
ID NO: 3)(PEG5000))4KKKK(SEQ ID NO: 23)DOTA?A-NH2, detecting said imaging agent and determining the levels and location of said imaging agent
in said test subject and comparing said levels and location with the levels and location of said imaging agent from an otherwise
identical location from an unaffected subject or with an unaffected area of said test subject, wherein a higher level or different
location of said imaging agent in said test subject compared with the level or location of said imaging agent in said sample
from an unaffected subject or from an unaffected area of said test subject, is an indication that said test subject has a
cancer expressing Plectin-1 or a homolog or fragment thereof, thereby detecting cancer, diagnosing cancer, monitoring the
progression of cancer, or monitoring treatment of a cancer, wherein said cancer cells express Plectin-1 or a homolog or fragment
thereof.

US Pat. No. 9,517,038

APPARATUS AND METHOD FOR BREAST IMMOBILIZATION

University of Virginia Pa...

1. An apparatus comprising:
a scanner configured to image internal structure of a biological specimen of a subject; and
an immobilization assembly configured to immobilize the specimen during an imaging session, wherein the immobilization assembly
includes:

a curved compression plate assembly having a first concave major surface;
a curved support plate assembly having a second concave major surface;
an assembly coupling configured to position the first concave major surface opposite the second concave major surface, wherein
a cross section view through the curved compression plate assembly and the curved support plate assembly includes two portions
of a single ellipse separated by a distance;

wherein the curved compression plate assembly and the curved support plate assembly are configured to immobilize the biological
specimen between the first concave major surface and the second concave major surface; and

wherein the curved compression plate includes a flat region contiguous with a portion of the first concave major surface,
wherein the flat region and a portion of the curved support plate assembly are configured to immobilize pectoral muscle of
the subject.

US Pat. No. 9,482,577

SEGMENTED CHIRPED-PULSE FOURIER TRANSFORM SPECTROSCOPY

University of Virginia Pa...

1. A method for obtaining an emission from a sample in response to excitation using a specified range of excitation frequencies,
the method comprising:
generating a chirped excitation signal;
applying the chirped excitation signal to the sample;
receiving an emission from the sample, the emission elicited at least in part by the chirped excitation signal; and
downconverting the received emission to provide a downconverted emission signal within the bandwidth of an analog-to-digital
converter (ADC);

wherein the generating the chirped excitation signal includes generating a first chirped waveform during a first duration,
and a second chirped waveform during a second duration, the first and second chirped waveforms including respective different
frequency ranges, the different frequency ranges having respective bandwidths specified based at least in part on the bandwidth
of the ADC and including a total bandwidth corresponding to the specified range of excitation frequencies.

US Pat. No. 9,741,833

EXTREMELY LARGE SPIN HALL ANGLE IN TOPOLOGICAL INSULATOR PN JUNCTION

UNIVERSITY OF VIRGINIA PA...

1. An electronic device comprising a topological insulator pn junction,
the topological insulator pn junction including:
a source;
a drain; and
a plurality of gates,wherein a chiral tunneling directs a movement of a plurality of electrons in the topological insulator pn junction.

US Pat. No. 9,366,697

MICROMACHINED ON-WAFER PROBES AND RELATED METHOD

University of Virginia Pa...

1. A device for probing a structure on a surface of an object substrate, said device comprising a compliant chip, wherein
said compliant chip comprises a monolithic integrated circuit assembly comprising integrated electrical interconnects, said
integrated electrical interconnects including:
at least one compliant beam oriented at a specified non-parallel angle with respect to said surface of said object substrate,
said at least one compliant beam configured to electrically and mechanically probe said structure on said object substrate;

at least one transmission circuit; and
a waveguide transition element, wherein said at least one transmission circuit suitable to electrically interconnect said
at least one compliant beam with said waveguide transition element.

US Pat. No. 9,337,204

MEMORY CELL

UNIVERSITY OF VIRGINIA PA...

9. A method of forming a memory cell including a pair of cross coupled inverters, said method comprising:
forming a metal 1 layer;
forming a first inverter, said first inverter including a substantially rectangular first gate conductor and a first contact;
forming a second inverter, said second inverter including a substantially rectangular second gate conductor and a second contact,
the second contact substantially aligned with a long axis of the first gate conductor, and the first contact substantially
aligned with a long axis of the second gate conductor; and

forming a buried conductive layer, the buried conductive layer providing connection for a PMOS diffusion, a pull down transistor
diffusion, and an access transistor diffusion on each side of the memory cell, and the buried conductive layer lying vertically
below and electrically insulated from the metal 1 layer.

US Pat. No. 9,265,410

SELF-ILLUMINATED HANDHELD LENS FOR RETINAL EXAMINATION AND PHOTOGRAPHY AND RELATED METHOD THEREOF

University of Virginia Pa...

1. A system for retinal photography, said system comprising:
a self-illuminated handheld fundus lens, comprising:
a viewing lens;
a contact lens configured to be applied to an eye of a subject;
an integrated light source;
an annular light channel through which light from the integrated light source is transmitted to the eye, wherein the annular
light channel comprises: a thinning of the contact lens, a portion of the contact lens that differs in power, a gap ground
into or provided in the contact lens, a gap around or adjacent to the contact lens, or a space behind or adjacent to the contact
lens; and

a light baffle separating the integrated light source and the light channel from a central aperture between the viewing lens
and the contact lens; and

an image recording device; and
a lens-to-camera interface, adapted to transmit an image from the lens to the image recording device.
US Pat. No. 9,244,075

COMPOSITIONS AND METHODS FOR DETECTING, DIAGNOSING, AND TREATING CANCER

University of Virginia Pa...

1. A method for treating SAS1R positive cancer comprising administering to a subject in need thereof an effective amount of
an antagonist of SAS1R, thereby treating a SAS1R positive cancer,
wherein said cancer is selected from the group consisting of uterine cancer, lung cancer, head and neck cancer, pancreatic
cancer, esophageal cancer, colorectal cancer, breast cancer, adenocarcinoma of the lung, squamous carcinoma of the lung, malignant
mixed mullerian tumor, leukemia, and lymphoma,

wherein said antagonist of SAS1R activity is an antibody that binds to one or more SAS1R protein fragments selected from the
group consisting of amino acids 1-25, 26-50, 51-75, 76-100, 101-125, 126-150, and 151-175 of SAS1R human variant 1 (SEQ ID
NO:23).

US Pat. No. 9,178,518

SUB-THRESHOLD FPGA AND RELATED CIRCUITS AND METHODS THEREOF

University of Virginia Pa...

1. A field programmable gate array (FPGA), comprising:
a circuit configured to operate in a sub-threshold voltage range,
wherein said circuit has a VDD level that is less than a threshold voltage of transistors in said circuit,

wherein said circuit employs a low-swing signaling scheme, and
wherein said low-swing signaling scheme is a signaling with a voltage swing that is less than said VDD level.

US Pat. No. 9,133,136

DUAL SMALL MOLECULE INHIBITORS OF CANCER AND ANGIOGENESIS

University of Virginia Pa...

1. A method to treat retinal or choroidal neovascularization or a disease associated therewith in a subject in need thereof
comprising administering to said subject an effective amount of at least one compound having the general structure of formula
I:

wherein R1, R3, and R4 are independently selected from the group consisting of NO2, H, halo, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 alkoxy, C5-C7 aryl, mono-, di- or tri-chloro, and mono-, di- or tri-methyl, R2 is H or R3 and R2 taken together with the atoms to which they are attached form an optionally substituted heterocyclic fused ring, or R3 and R4 taken together with the atoms to which they are attached form an optionally substituted cycloalkyl fused ring;

X is selected from the group consisting of NR5, —(NH(CH2)n)—, CH2, CHR5 and CO; wherein n is 1 or 2;

Z is selected from the group consisting of a bond, O, NH, S, CO, COO, CH2O, CH2NH, CONH, C1-C4 alkyl, C1-C4 alkenyl, and C1-C4 alkynyl; and

R2 and R5 are independently selected from the group consisting of H, halo, C5-C6 aryl, C1-C4 alkyl, C1-C4 alkenyl, and C1-C4 alkynyl, or R3 and R5 taken together with the atoms to which they are attached form an optionally substituted heterocyclic fused ring,

thereby treating retinal or choroidal neovascularization or a disease associated therewith in said subject, wherein the disease
associated with retinal or choroidal neovascularization is diabetic retinopathy, retinopathy of prematurity, macular degeneration,
or chronic retinal detachment.

US Pat. No. 9,873,852

GAS-EXPANDED LUBRICANTS FOR INCREASED ENERGY EFFICIENCY AND RELATED METHOD AND SYSTEM

University of Virginia Pa...

1. A method of lubricating at least one moving part with a medium, wherein said method comprises:
delivering the medium to at least one moving part for lubrication, wherein said medium when supplied to at least one moving
part for lubrication is comprised of a completely dissolved mixture of a lubricant and a compressed gas.

US Pat. No. 9,492,448

COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION

University of Virginia Pa...

1. A method for treating ischemia reperfusion injury wherein said method comprises administering to a subject in need thereof
a pharmaceutical composition comprising a pharmaceutically acceptable carrier, optionally at least one additional therapeutic
agent, and an effective amount of at least one compound selected from the group consisting of:

thereby treating ischemia reperfusion injury.

US Pat. No. 9,212,127

T TYPE CALCIUM CHANNEL INHIBITORS

University of Virginia Pa...

1. A compound of structural formula
wherein
R1 is hydroxy, or C1-C4 alkoxy;

Z is NH, NCH3, O, or S;

Y is CH2;

R2 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy;

m and n are independently selected from integers ranging from 1-5 with the proviso that m+
n=an integer ranging from 2-9; and
R3 is chloro;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,028,893

OSTOMY PUMP SYSTEM AND RELATED METHODS OF USE AND MANUFACTURE

University of Virginia Pa...

1. A device for refeeding bowel content of a subject, said device comprises:a proximal member configured to cover a proximal ostomy of a subject;
a distal member configured to cover a distal ostomy of a subject;
a bowel lumen member having a proximal end and a distal end, said proximal end of said bowel lumen is disposed at said proximal member and said distal end of said bowel lumen is disposed at said distal member, and wherein said bowel member is configured to carry bowel contents between the proximal ostomy and the distal ostomy;
a proximal balloon configured to be disposed in the bowel respective to the proximal ostomy;
a distal balloon configured to be disposed in the bowel respective to the distal ostomy;
a proximal inflation lumen configured to inflate said proximal balloon so as to engage and contact a circumferential area of a proximal bowel;
a distal inflation lumen configured to inflate said distal balloon so as to engage and contact a circumferential area of a distal bowel;
wherein said proximal member comprises a proximal member passage configured to allow the passage of said proximal end of said bowel lumen and proximal inflation lumen there through, and said proximal balloon is configured to allow for said bowel lumen to pass there through;
wherein said distal member comprises a distal member passage configured to allow the passage of said distal end of said bowel lumen and distal inflation lumen there through, wherein said distal balloon is configured to allow for said bowel lumen to pass there through; and
a multilumen structure, wherein:
said multilumen structure passes through said proximal member and configured to pass through the proximal ostomy,
said multilumen structure passes through said distal member and configured to pass through the distal ostomy,
said bowel lumen member passes through said multilumen structure,
said proximal balloon and said distal balloon are disposed inside said multilumen structure, and
said proximal inflation lumen and said distal inflation lumen passes through said multilumen structure.

US Pat. No. 10,032,950

ALLNASSB AVALANCHE PHOTODIODE AND RELATED METHOD THEREOF

University of Virginia Pa...

1. An avalanche photodiode comprising:a first contact layer;
a multiplication layer adjacent to said first contact layer, wherein said multiplication layer comprises AlInAsSb;
a charge layer adjacent to the multiplication layer opposite said first contact layer, wherein said charge layer comprises AlInAsSb;
an absorption layer adjacent to said charge layer, opposite said multiplication layer, wherein said absorption layer comprises AlInAsSb;
a blocking layer adjacent to said absorption layer, opposite said charge layer; and
second contact layer adjacent said blocking layer, opposite said absorption layer.

US Pat. No. 9,949,722

SYSTEM AND METHOD FOR BINDING DYNAMICS OF TARGETED MICROBUBBLES

University of Virginia Pa...

1. An ultrasound system, comprising:a receive beamformer configured to receive echo data from a transducer, wherein the echo data is reflected from a region of interest, wherein the echo data is elicited by a transmitted pulse sequence, wherein the transmitted pulse sequence includes imaging pulses and acoustic radiation force pulses, wherein the transmitted pulse sequence includes a first temporal period including acoustic radiation force pulses and a second temporal period not including acoustic radiation force pulses;
a processor coupled to the receive beamformer, the processor configured to:
determine a central tendency of a signal magnitude from regions of adherent microbubbles over time within the region of interest, using the echo data;
determine a time series of the central tendency of the signal magnitude;
determine an initial signal magnitude parameter, using the time series;
obtain a saturated signal magnitude parameter and a residual signal magnitude parameter using the time series, wherein the residual signal magnitude parameter is obtained from the second temporal period;
determine a relative indication of information indicative of the residual signal magnitude parameter versus the saturated signal magnitude parameter based on the initial signal magnitude parameter, the saturated signal magnitude parameter, and the residual signal magnitude parameter; and
a display configured to display the relative indication, wherein the relative indication is indicative of a concentration of specifically adherent microbubbles in the region of interest.

US Pat. No. 9,941,838

LOW VOLTAGE CRYSTAL OSCILLATOR (XTAL) DRIVER WITH FEEDBACK CONTROLLED DUTY CYCLING FOR ULTRA LOW POWER

UNIVERSITY OF VIRGINIA PA...

1. An apparatus, comprising:a crystal oscillator (XTAL) configured to generate an XTAL oscillation; and
a time constant generation circuit operatively coupled to the XTAL, the time constant generation circuit including:
a first comparator configured to set a high value for a counter to start counting when an amplitude of the XTAL oscillation crosses a first threshold voltage, and
a second comparator configured to set a zero value for the counter to stop counting when the amplitude of the XTAL oscillation crosses a second threshold voltage, a count of the counter corresponding to a time constant of the XTAL oscillation.

US Pat. No. 9,891,300

METHOD AND APPARATUS FOR ACQUIRING MAGNETIC RESONANCE DATA

University of Virginia Pa...

1. A method for acquiring magnetic resonance (MR) data from a subject comprising:
with a control computer, operating an MR data acquisition unit, in which a subject is situated, according to a single-slab
three-dimensional turbo spin-echo pulse sequence, in order to acquire raw MR data from the subject;

in said pulse sequence, selecting an inner volume of the subject in order to acquire said raw MR data only from said inner
volume, by activating a first gradient field in a first direction and activating a second gradient field in a second direction
that is not aligned with said first direction;

in said pulse sequence, exciting nuclear spins of the subject in said inner volume by radiating a radio-frequency (RF) excitation
pulse followed by at least one adiabatic RF pulse pair, with at least one of said RF excitation pulse and said at least one
adiabatic pulse pair being respectively simultaneously activated with one of said first and second gradient fields, with said
inner volume being defined by at least the first and second directions and the respectively simultaneously radiated RF pulses;
and

providing said raw MR data to a control computer and, via said control computer, entering said raw MR data into an electronic
memory organized as k-space, thereby producing k-space data in said electronic memory and, via said control computer, making
said k-space data available in electronic form as a data file from said control computer.

US Pat. No. 9,778,112

SEGMENTED CHIRPED-PULSE FOURIER TRANSFORM SPECTROSCOPY

University of Virginia Pa...

1. A method, comprising:
receiving a first emission signal from a sample, the first emission signal spanning a first bandwidth and elicited at least
in part by a first excitation signal applied to sample;

mixing the first emission signal with a first local oscillator (LO) to generate a first downconverted emission signal within
a conversion bandwidth of an analog-to-digital converter (ADC);

digitizing the first downconverted emission signal with the ADC to generate a first digital signal;
receiving a second emission signal from the sample, the second emission signal spanning a second bandwidth different than
the first bandwidth and elicited at least in part by a second excitation signal applied to the sample;

mixing the second emission signal with a second local oscillator (LO) to generate a second downconverted emission signal within
the conversion bandwidth of the ADC;

digitizing the second downconverted emission signal with the ADC to generate a second digital signal; and
combining the first digital signal and the second digital signal to form a combined digital signal having a bandwidth greater
than the conversion bandwidth of the ADC.

US Pat. No. 9,746,361

GASEOUS FLOW SENSOR AND RELATED METHOD THEREOF

University of Virginia Pa...

1. A low power electronic sensing device for use in measuring gaseous flow, said device comprising:
a dielectric layer with a first surface in communication with a flow to be measured;
a substrate in communication with a second surface of said dielectric layer, the substrate comprising silicon;
a cavity in said substrate, wherein a portion of said dielectric layer is substantially in communication with said cavity
to form a diaphragm; and

a conductive layer disposed on or inside said diaphragm;
wherein the dielectric layer is adhered to the substrate using a porous silicon attachment layer.

US Pat. No. 9,688,668

LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS

University of Virginia Pa...

1. A compound that is selected from the group consisting of:

and pharmaceutically acceptable salts thereof.

US Pat. No. 9,651,645

SYSTEMS AND METHODS FOR REDUCED OFF-RESONANCE BLURRING IN SPIRAL IMAGING

University of Virginia Pa...

1. A method, comprising:
acquiring imaging data associated with an area of interest of a subject, the acquiring comprising:
acquiring first spiral interleaf data for each of one or more spiral interleaves by performing a first sampling of each of
one or more locations in k-space with a spiral-in arm, and,

acquiring second spiral interleaf data for each of the one or more spiral interleaves by performing a second sampling of each
of the one or more locations in the k-space with a spiral-out arm,

wherein the second spiral interleaf data corresponds to a retracing of the spiral-in trajectory through k-space in an opposite
direction; and

averaging the first spiral interleaf data and the second spiral interleaf data to correct for one or more artifacts.

US Pat. No. 9,360,545

MAGNETIC RESONANCE SYSTEM AND OPERATING METHOD FOR FLOW ARTIFACT REDUCTION IN SLAB SELECTIVE SPACE IMAGING

Siemens Aktiengesellschaf...

1. A method for generating a magnetic resonance image, comprising:
operating a magnetic resonance image data acquisition unit according to an imaging pulse sequence comprising an excitation
radio-frequency (RF) pulse and a plurality of refocusing RF pulses temporally following said excitation RF pulse, said plurality
of refocusing RF pulses including a first refocusing RF pulse and a second refocusing RF pulse;

also operating said magnetic resonance image data acquisition unit in said imaging pulse sequence to shorten a time between
dephasing of signals and readout of magnetic resonance data, by activating no dephasing gradient between said excitation RF
pulse and said first refocusing RF pulse, and by activating a dephasing gradient in a readout direction between said first
refocusing RF pulse and said second refocusing RF pulse and, not until after said second refocusing RF pulse, activating a
readout gradient in said readout direction and, during said readout gradient, reading out magnetic resonance data from an
object, animal or human subject, with a substance therein exhibiting a flow, exposed to said imaging pulse sequence in said
magnetic resonance data acquisition unit; and

supplying said magnetic resonance data to a computerized processor and, in said computerized processor, reconstructing a magnetic
resonance image from said magnetic resonance data that is substantially free of artifacts related to said flow because of
the shortened time between said dephasing gradient and reading out said magnetic resonance data with said readout gradient,
and making said magnetic resonance image available as a data file at an output of said computerized processor.

US Pat. No. 9,151,708

ADAPTABLE CELL DESIGN FOR A SPECTROSCOPY APPARATUS

University of Virginia Pa...

1. An assembly comprising:
an optical cell apparatus comprising:
a hollow tubular body comprising a wall of the optical cell apparatus, the tubular body having longitudinally spaced first
and second body ends and surrounding a longitudinal axis of the optical cell to define a member lumen therethrough;

a first end member that is substantially rigid and attached to the first body end to define a first optical cell end;
a first optical element, located within the member lumen and fixedly attached to the first end member;
a second end member that is substantially rigid and attached to the second body end to define a second optical cell end; and
a second optical element, located within the optical cell and fixedly attached to the second end member; and
a first actuator mounted external to the member lumen and coupled to the first and second end members externally to the member
lumen, the first actuator configured to apply a force to displace the first end member relative to the second end member in
a direction substantially parallel to the longitudinal axis, the displacement sufficient to elastically deform the hollow
tubular body of the optical cell apparatus such that a longitudinal distance between the first optical element and the second
optical element is responsively altered.

US Pat. No. 9,993,585

METHOD SUCTION DEVICE AND RELATED METHOD THEREOF

University of Virginia Pa...

1. A medical suction device for use on a subject, wherein said device is to be used with a vacuum source for the purpose of transferring material from a region of the subject to a collection area, and for mitigating or preventing obstruction in said device, said device comprising:a lumen having an inner wall and an outer wall, said lumen having a distal end and a proximal end, said proximal end being in communication with the vacuum source, said distal end including a distal aperture, wherein said lumen is configured to be used in the region of the subject;
a retention member that is in communication with said lumen;
an elongated interacting member substantially aligned with said lumen, said elongated interacting member having a distal end and a proximal end;
an actuator in communication with said elongated interacting member, wherein said actuator is configured to drive said distal end of said elongated interacting member through said distal aperture and adjacent to said distal aperture to interact with the material in said distal aperture or lumen to assist the material transfer by mitigating or preventing obstruction in said distal aperture or said lumen by the material, and wherein said retention member is configured to have said elongated member routed there through, and wherein said retention member is configured to reroute a portion of said elongated member from said retention member through said distal aperture and adjacent to said distal aperture, while said lumen is configured to remain in communication with the vacuum source and remain in the region of the subject; and
wherein said distal end of said elongated interacting member that includes:
a ring and a plurality of protrusions that are circumferentially disposed on said distal end ring of said elongated interacting member, and
wherein said distal end of said lumen has a tip section that includes:
a plurality of side wall apertures traversing through said inner wall and outer wall of said lumen, wherein said plurality of side wall apertures are circumferentially disposed along said inner wall and outer wall of said lumen and are aligned to coincide with circumferential configuration of said plurality of circumferential protrusions, respectively, whereby the coinciding alignment provides a configuration whereby said plurality of circumferential protrusions obstruct said plurality of side wall apertures so as to improve suction through said distal aperture of said lumen.

US Pat. No. 9,709,029

MORPHING SEGMENTED WIND TURBINE AND RELATED METHOD

University of Virginia Pa...

1. A rotor blade for a wind turbine, said blade comprising:
a plurality of blade segments for use as part of a rotor;
each of said plurality of blade segments comprising an internal passage extending longitudinally from a first end to a second
end of each of said blade segments;

a plurality of spar members extending longitudinally through said internal passages of each of said blade segments such that
said plurality of said spar members are aligned and in communication end-to-end through said internal passages and said plurality
of blade segments are aligned and in communication with said aligned spar members and define a complete rotor blade from a
root that connects to a rotor hub to a blade tip of said rotor blade;

a tension member extending longitudinally through said aligned spar members, said tension member configured to exert a force
longitudinally toward said rotor hub to establish a first pitch configuration of said plurality of blade segments in the absence
of centrifugally-induced rotation of said blade segments about an axis of said longitudinally-extending plurality of spar
members;

wherein said aligned spar members are configured to rotate relative to one another about said axis in response to centrifugal
forces exerted on said blade segments and said aligned spar members due to a prevailing wind, and in response, said blade
segments are configured to rotate relative to one another to establish a second pitch configuration.

US Pat. No. 9,708,664

COMPOSITIONS AND METHODS FOR IDENTIFYING AND DIAGNOSING SALT SENSITIVITY OF BLOOD PRESSURE

University of Virginia Pa...

1. A method for determining salt sensitivity of blood pressure in a subject, said method comprising determining whether said
subject has at least one single nucleotide polymorphism associated with salt sensitivity of blood pressure, wherein a sample
from said subject is analyzed and detection of said at least one single nucleotide polymorphism in said sample is an indication
of salt sensitivity in said subject, wherein at least one of said single nucleotides polymorphisms is rs7571842 or rs10177833
of the sodium bicarbonate co-transporter gene (SLC4A5), thereby determining salt sensitivity of blood pressure in said subject.

US Pat. No. 9,682,078

COMPOSITIONS AND METHODS FOR TISSUE ENGINEERING AND CELL BASED THERAPIES

University of Virginia Pa...

1. A method for mobilizing hemopoietic stem cells into circulation in a subject in need thereof, said method comprising administering
to said subject an effective amount of an S1P3 receptor antagonist and optionally a CXCR4 antagonist, wherein said CXCR4 antagonist is AMD3100:
and wherein said S1P3 receptor antagonist is selected from the group consisting of:
thereby mobilizing said hemopoietic stem cells into circulation.
US Pat. No. 9,662,406

UNIT DOSAGE OF APADENOSON

University of Virginia Pa...

1. A method of chemically inducing stress and diagnosing myocardial perfusion abnormalities in a mammal, comprising:
(a) selecting a dose of Apadenoson between about 76-175 ?g on a basis that is independent of the weight of the mammal to whom
the dose will be administered;

(b) administering to said mammal, via bolus, the dose of Apadenoson as a unit dose comprising Apadenson and a pharmaceutically
acceptable carrier; and

(c) performing a technique to detect the presence of coronary artery stenoses in the mammal, to assess the severity of coronary
artery stenoses in the mammal, or a combination thereof, so as to diagnose myocardial perfusion abnormalities in said mammal.

US Pat. No. 9,571,312

EXPURGATED PULSE POSITION MODULATION FOR COMMUNICATION

University of Virginia Pa...

1. A system comprising:
a digital modulator circuit configured to provide digitally encoded information using a pulse-position modulation (PPM) encoding
scheme, the pulse-position modulation encoding scheme including modulated information comprising a linear combination of expurgated
PPM (EPPM) symbols, the EPPM symbols selected from a constellation including (1) a cyclic series of symbols or (2) a combination
of the cyclic series of symbols and logical complements of the cyclic series of symbols; and

a wireless transmitter configured to receive the digitally encoded information from the digital modulator circuit and configured
to wirelessly transmit the modulated information by varying an amplitude of an output signal.

US Pat. No. 9,555,467

AMORPHOUS STEEL COMPOSITES WITH ENHANCED STRENGTHS, ELASTIC PROPERTIES AND DUCTILITIES

University of Virginia Pa...

1. A method for enhancing the toughness of amorphous steel alloy that comprises:
a) milling carbide or nitride ceramic particulates to obtain a desired particle size distribution;
b) mixing the milled particles with ingots of monolithic amorphous steel alloy;
c) compacting the mixture to form a pellet; and
c) melting the pellet at a temperature above the melting point for the steel but below the melting point for the ceramic to
form a composite ingot.

US Pat. No. 9,421,177

IMIDAMIDE SPHINGOSINE KINASE INHIBITORS

University of Virginia Pa...

1. A compound of formula IA:
wherein
R1 is hydrogen or OH;

Y is C?O (carbonyl);
Z is
A. (C12-C20)alkylaryl, wherein Z is optionally substituted with a (C6-C10)alkoxycycloalkyl, (C6-C10)alkoxyphenyl, phenyl, or a (C3-C7)cycloalkyl;

B. (C5-C12 )alkyl-4-phenyl substituted with (C5-C10)cycloalkyl—O; or

C. a substituent selected from the group consisting of
or a pharmaceutically acceptable salt or ester thereof.

US Pat. No. 9,962,071

SELF-ILLUMINATED HANDHELD LENS FOR RETINAL EXAMINATION AND PHOTOGRAPHY AND RELATED METHOD THEREOF

University of Virginia Pa...

1. A self-illuminated handheld lens for wide angle retinal viewing of a subject eye, comprising:an aspherical viewing lens having a symmetric viewing axis and defining a central aperture;
a contact lens positioned in front of said aspherical viewing lens to be applied to said subject eye;
plurality of LEDs positioned around said viewing axis and configured to illuminate said subject eye outside from said central aperture; and
a light baffle configured to block stray light of said LEDs from getting into said central aperture.

US Pat. No. 9,908,849

IMIDAMIDE SPHINGOSINE KINASE INHIBITORS

University of Virginia Pa...

1. A method for treatment of a disease selected from a neoplastic disease, an autoimmune disease, or asthma in a mammal suffering
therefrom, comprising administering to said mammal an effective amount of a compound of formula IA:
wherein
R1 is hydrogen or OH;

Y is C?O (carbonyl);
Z is
A. (C12-C20)alkylaryl, wherein Z is optionally substituted with a (C6-C10)alkoxycycloalkyl, (C6-C10)alkoxyphenyl, phenyl, or a (C3-C7)cycloalkyl;

B. (C5-C12)alkyl-4-phenyl substituted with (C5-C10)cycloalkyl-O; or

C. a substituent selected from the group consisting of
or a pharmaceutically acceptable salt or ester thereof.

US Pat. No. 9,761,154

TRACHEOSTOMY TRAINER DEVICE AND RELATED METHOD THEREOF

University of Virginia Pa...

1. A kit for training an operator to care for a subject with a tracheostomy, said kit comprising a device comprising: a container
or housing, wherein said container or housing comprises a rigid or semi-rigid surface; said container or housing having a
bottom, wherein said bottom of said container or housing includes a bottom aperture configured to accommodate a plug that
is configured to close said bottom aperture; said rigid or semi-rigid surface including at least one surface aperture; at
least one diaphragm in communication with said rigid or semi-rigid surface; at least one diaphragm aperture in each of said
at least one diaphragm; said at least one diaphragm aperture being smaller in size than said surface aperture; said at least
one diaphragm aperture being configured for an interference fit with an outer portion of a tracheotomy tube or penetrating
instrument; said interference fit configured to produce an initial resistance to insertion of said tracheotomy tube or penetrating
instrument followed by lower resistance after said tracheotomy tube or penetrating instrument is displaced past a threshold
of said at least one diaphragm aperture causing a sudden change in resistance; and said sudden change in resistance configured
to provide said inexperienced operator with a tactile sensation similar to that of insertion of a tracheotomy tube into the
tracheostomy of the subject; and wherein said kit is provided with said plug, wherein said plug is configured to close said
bottom aperture.

US Pat. No. 9,750,438

CGM-BASED PREVENTION OF HYPOGLYCEMIA VIA HYPOGLYCEMIA RISK ASSESSMENT AND SMOOTH REDUCTION OF INSULIN DELIVERY

UNIVERSITY OF VIRGINIA PA...

1. A computer-implemented method for preventing or mitigating hypoglycemia in a patient, comprising:
receiving by a processor continuous metabolic measurements associated with the subject from a metabolic measurement device
continuously making direct metabolic measurements;

continuously assessing by a processor a risk of hypoglycemia based on the received metabolic measurements;
evaluating by a processor risk of hypoglycemia based on the assessed risk of hypoglycemia; and
outputting to an output device a result of said evaluation, selected from one of:
a) no action being needed;
b) attenuation of insulin delivery being needed;
c) additional patient intervention being needed; and
d) attenuation of insulin delivery and additional patient intervention being needed.

US Pat. No. 9,314,265

ACCESS NEEDLE PRESSURE SENSOR DEVICE AND METHOD OF USE

University of Virginia Pa...

1. A system for accessing one or more locations of a subject, said device comprising:
an elongated member having a distal end and a proximal end;
a pressure sensor in communication with said elongated member;
a processor configured to:
receive sensed information from said pressure sensor, and
to detect a change in a sensed pressure frequency based on the sensed information;
a reading system configured to present the pressure frequency to a user; and
an alarm that is configured to provide an alert in response to a change in the sensed pressure frequency.
US Pat. No. 9,981,012

COMPOSITIONS AND METHODS FOR PROTECTING THE KIDNEY FROM ISCHEMIA REPERFUSION INJURY

University of Virginia Pa...

1. A method for preventing or treating renal ischemia reperfusion injury or acute kidney injury associated with renal ischemia reperfusion injury, said method comprising administering to a subject in need thereof a pharmaceutical composition comprising an effective amount of hepcidin or a biologically active fragment or homolog thereof, wherein said hepcidin or biologically active fragment or homolog thereof comprises a sequence selected from the group consisting of SEQ ID NOs:1, 2, 3, 4, and 5, thereby preventing or treating renal ischemia reperfusion injury or acute kidney injury associated with renal ischemia reperfusion injury.

US Pat. No. 9,977,112

OBJECT LOCALIZATION WITH RFID INFRASTRUCTURE

University of Virginia Pa...

1. A system comprising:a search circuit configured to search a plurality of transmission power levels established by a radio-frequency identification (RFID) reader, the search circuit configured to determine a measurement power level corresponding to a target, wherein to search the plurality of transmission power levels the search circuit uses at least one of a linear search or a binary search, wherein the linear search uses variable power step sizes to establish a fixed number of intervals within a variable power range, and wherein the binary search halves step sizes during each iteration of the search; and
a target localization circuit configured to:
select a reference location from a plurality of reference locations via determining a greater affinity between the measurement power level and a reference power level corresponding to a reference location than between the measurement power level and other reference power levels corresponding to other respective reference locations; and
determine a region that includes the target using information about a physical relationship between the RFID reader and the reference location via correlating the measurement power level to the reference power level, wherein the physical relationship between the RFID reader and the reference location is fixed with respect to the reference power level that was previously established via interrogation of the reference location by the RFID reader at a fixed position, and wherein the affinity between the measurement power level and the reference power level is determined by a heuristic selected from a group of heuristics that includes:


wherein:
T=Target;
J,K=Iteration variables for neighbourhood reference locations;
RJ=Reference location J;
RK=Reference location K;
?I(R)=|Power(T)?Power(R)| using reader I, wherein Power is the transmission power level;
M=Number of RFID readers used;
B=Set of neighbour reference locations;
H=Heuristic; and
L=Iteration variable for heuristics.

US Pat. No. 9,924,923

ULTRASOUND IMAGING OF SPECULAR-REFLECTING TARGET

University of Virginia Pa...

1. An ultrasound diagnostic apparatus, comprising:one or more ultrasonic transducers configured to mechanically scan a tissue region including an imaging target; and
a mechanical positioner configured to position the one or more ultrasonic transducers to:
receive first echo information corresponding to a first volume of tissue defined at least in part by a first location of one or more ultrasonic transducers; and
receive second echo information corresponding to a second volume of tissue defined at least in part by a second location of one or more ultrasonic transducers, the second volume spatially overlapping with the first volume of tissue in a portion of the tissue region; wherein the first location and the second location are separated by at least one wavelength corresponding to a center frequency of ultrasonic energy used for tissue insonification.

US Pat. No. 9,839,364

VENTRICULAR ACTIVATION (RR) ENTROPY CHANGE AS A PREDICTOR OF SUDDEN CARDIAC DEATH IN CARDIAC RESYNCHRONIZATION THERAPY PATIENTS

University of Virginia Pa...

1. A method for determining increased risk of mortality of a patient, comprising:
measuring a first cardiac rhythm of a patient at a first time;
identifying at least one segment of said first cardiac rhythm;
calculating a first entropy measurement for the at least one segment;
measuring a second cardiac rhythm of said patient at a second time subsequent to said first time;
identifying at least one segment of said second cardiac rhythm;
calculating a second entropy measurement for the at least one segment of said second cardiac rhythm;
calculating a change in entropy by comparing said second entropy measurement with said first entropy measurement; and
determining that said patient is at an increased risk of mortality when said change in entropy is above a predetermined value.

US Pat. No. 9,611,153

COMPOSITIONS AND METHODS FOR PREPARING COPPER-CONTAINING PAPER AND USES THEREOF

University of Virginia Pa...

1. A method of preparing a point-of-use water purification system comprising copper-containing paper, the method comprising:
contacting an absorbent cellulose blotting paper or filter paper with an alkaline solution of copper hydroxide and soaking
the paper in said solution, wherein copper is sorbed onto the paper;

wherein the alkaline copper hydroxide solution is prepared by adding 1 M NaOH to a 0.32 M CuSO4 solution to form gelatinous copper hydroxide (Cu(OH)2) and dissolving the gelatinous Cu(OH)2 in 500 ml of 10 M NaOH to form [Cu(OH)4]2?, thereby preparing the alkaline copper hydroxide solution;

removing the paper from the copper hydroxide solution and then contacting the paper with deionized water to remove excess
base;

following removing the excess base, reducing copper ions embedded in the paper by contacting the paper with an ascorbic acid
solution;

removing the paper from ascorbic acid solution; and
washing the paper with deionized water,
thereby preparing the point-of-use water purification system.

US Pat. No. 9,398,869

METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR IMPROVING THE ACCURACY OF GLUCOSE SENSORS USING INSULIN DELIVERY OBSERVATION IN DIABETES

University of Virginia Pa...

1. A processor implemented method for improving the accuracy of a glucose measurement device, said method comprising:
obtaining a glucose level readout of a subject, from said glucose measurement device;
obtaining insulin delivery information from an insulin delivery device;
performing a first intermediary computation using said glucose level readout from said glucose measurement device and said
insulin delivery information, to obtain an output of said first intermediary computation;

performing a second intermediary computation using said output of said first intermediary computation to obtain an output
of said second intermediary computation;

performing a third computation to reach an estimate of the blood glucose of the subject by applying a weighting scheme to
said readout from the glucose measurement device and said output of said second intermediary computation; and

determining, based at least in part on said estimate of the blood glucose of the subject, an amount of insulin to be delivered
to the subject by the insulin delivery device;

wherein the insulin delivery device is configured to deliver the determined amount of insulin to the subject.
US Pat. No. 9,075,059

COMPOSITIONS AND METHODS FOR DETECTING PLECTIN-1 AS A BIOMARKER FOR CANCER

University of Virginia Pa...

1. A tetrameric peptide ligand complex for binding to Plectin-1 or a homolog or fragment thereof, wherein said complex has
the formula (?AKTLLPTPGGS(PEG5000))4 KKKKDOTA?A-NH2, wherein said tetrameric complex has a Ki of about 8.3×10?7 M.

US Pat. No. 9,953,439

SYSTEMS AND METHODS FOR THREE-DIMENSIONAL SPIRAL PERFUSION IMAGING

University of Virginia Pa...

1. A method for perfusion imaging of a subject, comprising:acquiring perfusion imaging data associated with the heart of a subject, the acquiring comprising applying an imaging pulse sequence with a three-dimensional stack-of-spirals trajectory;
reconstructing perfusion images from the acquired perfusion imaging data, wherein the reconstructing comprises parallel imaging and motion-guided compressed sensing;
determining absolute perfusion values from the reconstructed perfusion images wherein the determining comprises transforming a volumetric imaging dataset associated with the reconstructed perfusion images into a set of time-intensity curves representative of time-intensity relationships; and
generating a quantitative volumetric perfusion flow map based on the determined absolute perfusion values;
wherein the absolute perfusion values are determined on a pixel-wise or segmental basis, from the time-intensity relationships, to quantify myocardial blood flow of the heart of the subject.

US Pat. No. 9,920,530

HEAT-MANAGING COMPOSITE STRUCTURES

University of Virginia Pa...

1. A structural arrangement, comprising:
an open-cell lattice-structure core;
a surface layer comprising a cellular sub-structure; and
a heat-transferring working fluid disposed within said core or said surface layer;
wherein the surface layer further comprises an outer arrangement that has lower thermal conductivity than the cellular sub-structure
of said surface layer.

US Pat. No. 9,921,170

APPARATUS AND TECHNIQUES FOR FOURIER TRANSFORM MILLIMETER-WAVE SPECTROSCOPY

University of Virginia Pa...

1. A method, comprising:
exciting a gaseous sample using a first pulsed excitation and a second pulsed excitation each including energy in a mm-wave
range of frequencies, the first pulsed excitation and the second pulsed excitation spaced apart in time by a specified duration
that is varied between respective measurement cycles, and the first and second pulsed excitations generated at least in part
using a frequency multiplier to provide the mm-wave range of frequencies;

obtaining respective time-domain representations elicited from the gaseous sample in response to the first and second pulsed
excitations corresponding to the respective measurement cycles;

determining a collisional relaxation time constant using the respective time-domain representations of the response; and
estimating a molecular mass of a species included in the gaseous sample at least in part using the determined collisional
relaxation time constant.

US Pat. No. 9,840,545

FUSION PROTEIN COMPRISING INTERLEUKIN-2 AND INTERLEUKIN-33

University of Virginia Pa...

1. A fusion protein comprising a biologically active domain of Interleukin-2 (IL-2) or a biologically active fragment thereof,
wherein said domain binds with the IL-2 receptor, and a biologically active domain of Interleukin-33 (IL-33) or a biologically
active fragment thereof, wherein said IL-33 domain binds with the IL-33 receptor, further wherein said IL-2 domain is linked
to said IL-33 domain with a linker sequence.
US Pat. No. 9,803,012

COMPOSITIONS AND METHODS FOR REGULATING SAS1R

UNIVERSITY OF VIRGINIA PA...

1. A method of identifying a compound which is an inhibitor of SAS1R, said method comprising:
(a) adding a test compound to a test sample comprising native SAS1R, wherein said test compound is an antibody that binds
to amino acids selected from the group consisting of 26-50, 51-75, 76-100, 101-125, 126-150, 151-175 and 176-200 of SAS1R
Variant 2 (SEQ ID NO:6); selected from the group consisting of 26-50, 51-75, 76-100, 101-125, 136-150, 151-175 and 176-200
of SAS1R Variant I (SEQ ID NO: 19); or selected from the group consisting of 26-50, 51-75, 76-100, 100-125, 126-150, 151-175
and 176-200 of SAS1R Variant I (SEQ ID NO:23);

(b) analyzing the level of SAS1R activity or expression in said test sample with the level of SAS1R activity or expression
in an otherwise identical sample comprising SAS1R not subjected to a test compound;

(c) wherein a lower level of SAS1R activity or expression in said test sample subjected to a test compound compared with the
level of SAS1R activity or expression in said otherwise identical sample is an indication that said test compound is an inhibitor
of SAS1R; and

(d) thereby identifying a compound which is an inhibitor of SAS1R.

US Pat. No. 9,642,534

SYSTEMS AND METHODS FOR DETERMINING LOCATION OF AN ACCESS NEEDLE IN A SUBJECT

University of Virginia Pa...

1. A method of inferring the location of a needle in a subject, the method comprising:
inserting a needle including a first sensor into a body of a subject;
receiving cardiac waveform information of the subject from a second sensor;
receiving pressure frequency information from the first sensor;
segmenting the pressure frequency information based at least in part on the cardiac waveform information;
processing the segmented pressure frequency information using an algorithm to obtain algorithm results; and
distinguishing, by a computer processor, a current location of the needle from another location based on comparing the algorithm
results to a plurality of predetermined threshold values.

US Pat. No. 9,442,079

CHIRPED PULSE FREQUENCY-DOMAIN COMB FOR SPECTROSCOPY

University of Virginia Pa...

1. A method, comprising: generating a plurality of pulse trains, each pulse train comprising chirped pulses of microwave,
millimeter-wave, and/or sub-millimeter wave electromagnetic energy; and exciting a sample using the plurality of pulse trains,
wherein generating the plurality of pulse trains comprises, for each chirped pulse of a first pulse train of the plurality
of pulse trains: generating a baseband chirped pulse; upconverting the baseband chirped pulse to generate an upconverted chirped
pulse; and frequency multiplying the upconverted chirped pulse to produce the chirped pulse in the first pulse train.
US Pat. No. 9,387,199

COMPOSITIONS AND METHODS FOR TREATING CLOSTRIDIUM INFECTION AND PREVENTING RECURRENCE OF INFECTION

University of Virginia Pa...

1. A method of treating a C. difficile infection in a subject using a short-term course of antibiotic treatment, said method comprising administering to said subject
a pharmaceutical composition comprising an antibiotic effective against C. difficile, wherein said antibiotic is selected from the group consisting of vancomycin, fidaxomicin, metronidazole, and nitazoxanide,
wherein said antibiotic is administered at a dosage ranging from about 0.1 mg/kg/day to about 20 mg/kg/day and said course
of antibiotic treatment is selected from the group consisting of 1, 2, 3 and 4 days, thereby treating the C. difficile infection in said subject using said short term course of antibiotic treatment.

US Pat. No. 10,107,560

MULTIFUNCTIONAL THERMAL MANAGEMENT SYSTEM AND RELATED METHOD

University of Virginia Pa...

1. An anisotropic thermal management system for thermally protecting a load-bearing surface, structure, or component against heat being transferred from a heat source to the load-bearing surface, structure, or component, said system comprising:a high thermal conductivity layer comprising a high thermal conductivity material, said high thermal conductivity layer providing in-plane heat spreading across said high thermal conductivity layer, said high thermal conductivity material is an alloy of aluminum, silver, copper, diamond, graphite, or other high thermal conductivity material with a thermal conductivity greater than about 10 W/mK, said high thermal conductivity layer having a flat layer structure with uniform thickness, said high thermal conductivity layer comprising a heat pipe system having multiple heat pipes or heat pipe channels located within said thickness of said high thermal conductivity layer and surrounded and enclosed within said high thermal conductivity layer; and
a low thermal conductivity layer comprising a low thermal conductivity material, said low thermal conductivity layer reducing heat transfer from the heat source through said high thermal conductivity layer and said low thermal conductivity layer to the load-bearing surface, structure, or component, said low thermal conductivity material comprises at least one of the following materials: aramid, polymer, polymer foams, wood, plaster, cement, concrete or any other low thermal conductivity material with a thermal conductivity less than about 1 W/mK,
wherein the anisotropic thermal management system is configured to be installed or located between the heat source and the load-bearing surface, structure, or component to thermally and reduce heat transfer from the heat source to the load-bearing surface, structure, or component,
wherein the low thermal conductivity layer is disposed atop the load-bearing surface, structure, or component,
wherein the high thermal conductivity layer is disposed atop the low thermal conductive layer, and
wherein the heat source is located atop and facing the high thermal conductivity layer.
US Pat. No. 10,046,030

COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING INFECTION

University of Virginia Pa...

1. A method for treating a Clostridium difficile (C. difficile) infection in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a pharmaceutically-acceptable carrier, an effective amount of IL-25 and optionally an additional therapeutic agent, thereby treating said C. difficile infection.
US Pat. No. 10,035,848

ANTIBODY TARGETING CELL SURFACE DEPOSITED COMPLEMENT PROTEIN C3D AND USE THEREOF

The United States of Amer...

1. An anti-C3d antibody or antibody fragment comprisinga heavy chain variable region comprising
SEQ ID NO: 1 as heavy chain complementary determining region-1 (CDRH1);
SEQ ID NO: 2 as heavy chain complementary determining region-2 (CDRH2); and
SEQ ID NO: 3 or 4 as heavy chain complementary determining region-3 (CDRH3); and
a light chain variable region comprising
SEQ ID NO: 5 as light chain complementary determining region-1 (CDRL1);
SEQ ID NO: 6 as light chain complementary determining region-2 (CDRL2); and
SEQ ID NO: 7 as light chain complementary determining region-3 (CDRL3).

US Pat. No. 9,962,101

ANALYSIS OF CARDIAC RHYTHM USING RR INTERVAL CHARACTERIZATION

University of Virginia Pa...

1. A method for analyzing at least one cardiac rhythm having an RR interval series, the method comprising:characterizing RR intervals by at least one dynamic parameter, including entropy;
combining the at least one dynamic parameter with at least one density parameter, including mean, standard deviation, or coefficient of variation (CV);
classifying the at least one cardiac rhythm based on the combination of the at least one dynamic parameter and the at least one density parameter; and
generating a diagnostic output based on the classification,
wherein the method employs multivariate statistical models.
US Pat. No. 9,937,234

COMPOSITIONS AND METHODS FOR USING AND IDENTIFYING ANTIMICROBIAL AGENTS

University of Virginia Pa...

1. A method for identifying antimicrobial agents, said method comprisingcontacting a parent E coli strain and a derivative strain with a candidate compound, wherein the derivative strain has been modified relative to said parent strain to be deficient in pyruvate dehydrogenase complex (PDHC) function further wherein said candidate compound is not an aminoglycoside;
culturing the parent E coli strain and said derivative strain under conditions suitable for growth;
identifying those candidate compounds that inhibit the growth of parent E. coli strain relative to the PDHC-deficient E. coli derivatives as antimicrobial agents.

US Pat. No. 9,931,086

APPARATUS AND METHOD FOR BREAST IMMOBILIZATION

University of Virginia Pa...

1. An immobilization assembly configured to couple to a scanner and to immobilize a biological specimen during an imaging session of the scanner, the immobilization assembly comprising:a curved compression plate assembly having a first concave major surface;
a curved support plate assembly having a second concave major surface;
an assembly coupling configured to position the first concave major surface opposite the second concave major surface, wherein a cross section view through the curved compression plate assembly and the curved support plate assembly includes two portions of a single ellipse separated by a distance;
a lead screw configured to simultaneously move the curved compression plate assembly and the curved support plate assembly along the linear axis; and
wherein the curved compression plate assembly and the curved support plate assembly are configured to immobilize the biological specimen between the first concave major surface and the second concave major surface.

US Pat. No. 9,895,158

METHOD AND APPARATUS FOR ACCELERATED DISINTEGRATION OF BLOOD CLOT

University of Virginia Pa...

134. A method of treating a blood clot, said method comprising:
inserting a catheter into a patient;
delivering low stability microbubbles from a microfluidics device within the catheter toward the blood clot in the patient,
wherein the microfluidics device is configured to focus gas and liquid streams at a nozzle to generate said microbubbles for
delivery out of said catheter and toward the blood clot;

real-time monitoring at least one of production rate and size of microbubbles produced, wherein said real-time monitoring
is performed in an automatic feedback loop;

automatically adjusting at least one of gas pressure, gas flow rate, liquid pressure and liquid flow rate to maintain stable
production rate and size of the microbubbles; and

applying ultrasonic energy to the microbubbles to vibrate the microbubbles.

US Pat. No. 9,865,713

EXTREMELY LARGE SPIN HALL ANGLE IN TOPOLOGICAL INSULATOR PN JUNCTION

UNIVERSITY OF VIRGINIA PA...

1. An electronic device comprising a topological insulator pn junction,
the topological insulator pn junction including:
a source;
a drain; and
a plurality of gates,wherein a chiral tunneling directs a movement of a plurality of electrons in the topological insulator pn junction.

US Pat. No. 9,748,430

STAIRCASE AVALANCHE PHOTODIODE WITH A STAIRCASE MULTIPLICATION REGION COMPOSED OF AN AIINASSB ALLOY

Board of Regents, The Uni...

1. A photodiode, comprising:
an avalanche multiplication region, wherein a combination of all layers of said avalanche multiplication region comprise a
graded aluminum indium arsenide antimonide (AlInAsSb) alloy grown lattice-matched or psuedomorphically strained on either
indium arsenide (InAs) or gallium antimonide (GaSb), wherein said graded avalanche multiplication region comprises multiple
bandgap steps in which a bandgap is varied from small to large and vice-versa; and

a photoabsorption layer for absorbing photons.

US Pat. No. 9,729,189

ULTRA LOW POWER SENSING PLATFORM WITH MULTIMODAL RADIOS

UNIVERSITY OF VIRGINIA PA...

1. An apparatus, comprising:
a system on a chip (SoC) including:
a power supply circuit;
a power management circuit operatively coupled to the power supply circuit;
a first wireless communications circuit configured to receive an RF signal and operatively coupled to the power supply circuit
and the power management circuit,

the first wireless communications circuit, when receiving an input signal power, has an output signal power that is no greater
in magnitude than the input signal power such that a net radio frequency (RF) power gain of the first wireless communications
circuit is at most unity and,

the first wireless communication circuit configured to remain operational at least nearly constantly during operation of the
SoC; and

a second wireless communications circuit operatively coupled to the power supply circuit and the power management circuit,
the second wireless communications circuit configured to be inactive or duty-cycled during at least an ultra-low power consumption
mode,

the first wireless communications circuit configured to consume less power than the second wireless communications circuit
during an operation of the SoC when the first wireless communications circuit and the second wireless communications circuit
are both operational in a same operational mode established by the power management circuit.

US Pat. No. 9,701,978

COMPOSITIONS AND RELATED METHODS FOR MODULATING ALKALOID PRODUCTION BY CONTROLLING PMT PROMOTER ACTIVATION MEDIATED BY TRANSCRIPTIONAL FACTORS ERF AND MYC

University of Virginia Pa...

1. An isolated cDNA molecule comprising a nucleotide sequence having at least 95% sequence identity to the nucleotide sequence
of SEQ ID NO:1.

US Pat. No. 9,635,033

METHODS, SYSTEMS AND COMPUTER READABLE MEDIA FOR DETECTING COMMAND INJECTION ATTACKS

University of Virginia Pa...

1. A system for detecting command injection attacks based on command instructions to be received from a client processor or
client data memory, said system comprising:
a memory unit operative to store software code; and
a processor configured to:
extract string fragments from said software code to provide extracted signature fragments;
receive said client command instructions;
convert the received command instructions into command fragments;
identify critical parts from said command fragments:
determine if said critical parts are untrusted or trusted by matching with said extracted signature fragments;
identify potential attacks upon the condition that a command includes critical parts that are untrusted; and
communicate said identification of potential attacks to an output device,
wherein the command fragments are different from external data processed by the software code, and the critical parts of the
command fragments do not originate from previously identified command fragments.

US Pat. No. 9,617,197

COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES

University of Virginia Pa...

1. A method to inhibit or treat inflammation, comprising: administering to a mammal in need thereof an amount of a composition
having a compound of formula (I) effective to enhance or augment aminopeptidase activity of leukotriene A4 hydrolase,wherein the compound of formula (I) is

US Pat. No. 9,610,370

COMPOSITIONS AND METHODS FOR TUMOR IMAGING AND TARGETING BY A CLASS OF ORGANIC HEPTAMETHINE CYANINE DYES THAT POSSESS DUAL NUCLEAR AND NEAR-INFRARED PROPERTIES

University of Virginia Pa...

1. A Dual Nuclear/NIR Agent having one of the following structures:

US Pat. No. 9,539,242

MOLECULAR GENETIC APPROACH TO TREATMENT AND DIAGNOSIS OF ALCOHOL AND DRUG DEPENDENCE

University of Virginia Pa...

1. A method of treating an alcohol-related disease or disorder, comprising: administering to a patient in need thereof a therapeutically
effective amount of ondansetron, wherein the disease or disorder is selected from: alcohol abuse, heavy drinking, excessive
drinking, and alcohol dependence and the patient's HTR3B gene and optionally serotonin transporter gene SLC6A4 and/or HTR3A
gene is known to have a genotype selected from sets (a.)-(d.):
(a.) the AC genotype of rs17614942;
(b.) the AC genotype of rs17614942, the LL genotype of 5-HTTLPR, and the TT genotype of rs1042173;
(c.) the AC genotype of rs17614942 and the LL genotype of 5-HTTLPR;
(d.) the AC genotype of rs17614942 and at least one genotype selected from:
i. the AA genotype of rs1176719;
ii. the LL genotype of 5-HTTLPR; and,
iii. the TT genotype of rs1042173.

US Pat. No. 9,445,780

TRACKED ULTRASOUND VESSEL IMAGING

University of Virginia Pa...

1. A non-transitory processor-readable medium comprising instructions that, when performed by the processor, cause the processor
to:
construct a first image of a plane parallel to the surface of an ultrasonic imaging transducer, the plane corresponding to
a locus at a specified depth within a first region of tissue, using information obtained from the imaging transducer;

obtain information about a location of a vessel in the first image;
obtain, from a second region of tissue, imaging information corresponding to loci in planes parallel to the surface of the
transducer, the planes at depths automatically determined at least in part using the obtained information about the location
of the vessel in the first image;

automatically determine an adjusted depth corresponding to the location of the vessel in the second region including:
determining a first depth using obtained imaging information indicative of a shallow boundary of the vessel, closer to the
imaging transducer in depth than a deep boundary of the vessel;

determining a second depth indicative of the deep boundary of the vessel;
estimating a depth corresponding to the center of the vessel between the shallow and deep boundaries; and
assigning the estimated depth as the adjusted depth; and
construct a second image of a plane parallel to the surface of the transducer, the plane corresponding to the adjusted depth
within the tissue;

wherein the first and second regions are offset from each other.

US Pat. No. 9,433,398

SEPARABLE BEAMFORMING FOR ULTRASOUND ARRAY

UNIVERSITY OF VIRGINIA PA...

1. An ultrasonic imaging system for use with an ultrasonic transducer array, the ultrasonic transducer array including transducer
elements arranged in a two-dimensional array defining a transducer plane and configured to insonify a tissue region with ultrasonic
energy, the system comprising a processor circuit configured to:
obtain, from the ultrasonic transducer array, information indicative of the reflected ultrasonic energy, including obtaining
complex samples of the reflected ultrasonic energy; and

construct a representation of an imaging plane, within the tissue region, including using the obtained information indicative
of the reflected ultrasonic energy including:

separately determining, for respective focusing locations in an imaging plane including a specified focusing location, respective
first sums of complex samples of reflected ultrasonic energy obtained via respective first lines of transducers in the ultrasonic
transducer array, the complex samples obtained via respective first lines of transducers corresponding to respective orthogonal
projections of the respective focusing locations in the imaging plane onto the respective first lines in the transducer plane;
and

separately determining, for the specified focusing location in the imaging plane, a second sum of at least some the respective
first sums of complex samples of reflected ultrasonic energy, the second sum corresponding to a second line of transducers
in the ultrasonic transducer array, the second line of transducers aligned along an axis different from an axis of the respective
first lines in the transducer plane and corresponding to the orthogonal projection of the specified focusing location in the
imaging plane onto the transducer plane;

wherein the separately determining the first or second sums of complex samples includes phase-rotating at least some of the
complex samples.

US Pat. No. 9,376,430

BROAD SPECTRUM BENZOTHIOPHENE-NITROTHIAZOLIDE AND OTHER ANTIMICROBIALS

UNIVERSITY OF VIRGINIA PA...

1. A method of treating or inhibiting a microbial infection or biofilm formation in a subject, said method comprising administering
to said subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier, optionally at least one additional
therapeutic agent, and a therapeutically effective amount of a compound selected from the group consisting of:

or a pharmaceutically acceptable salt or prodrug thereof.

US Pat. No. 9,183,626

SYSTEMS AND METHODS FOR ACCELERATED ARTERIAL SPIN LABELING USING COMPRESSED SENSING

UNIVERSITY OF VIRGINIA PA...

1. A method, comprising:
acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds
to at least one physiological activity of the subject; and

performing image reconstruction, comprising compressed sensing reconstruction, on at least a portion of the acquired magnetic
resonance data,

wherein acquiring the magnetic resonance data comprises receiving data associated with arterial spin labeling (ASL) of the
area of interest of the subject, and

wherein performing the image reconstruction comprises estimating a current state of the area of interest from image data corresponding
to a past state of the area of interest based on spatiotemporal sparsity.

US Pat. No. 9,102,799

VISCOELASTIC SILICONE RUBBER COMPOSITIONS

University of Virginia Pa...

6. A viscoelastic silicone rubber composition comprising the reaction product of:
(a) a silanol-terminated polorganosiloxane base;
(b) a boron-containing crosslinking agent; and
(c) a siloxane bond-forming crosslinking agent in an amount sufficient to give the viscoelastic silicone rubber composition
an equilibrium shape, wherein:

the boron-containing crosslinking agent is present in an amount ranging from 20% to 200% saturation; and
the siloxane bond-forming crosslinking agent is present in an amount ranging from 20% to 100% saturation.

US Pat. No. 9,050,596

PASSIVE COMPONENTS FOR MICRO-FLUIDIC FLOW PROFILE SHAPING AND RELATED METHOD THEREOF

University of Virginia Pa...

1. A fluidic capacitor comprising
a first layer having a continuous fluid path thereon;
a second layer having a recess thereon;
a third layer of elastomeric material, wherein the third layer is sandwiched between the first layer and second layer such
that the recess is in direct alignment with the fluid path, the recess fluidically isolated from the continuous fluid path
by the elastomeric material;

wherein the continuous fluid path, the recess on the second layer, and the elastomeric material are configured to control
a fluid flow rate through the continuous fluid path on the first layer in response to a predetermined frequency of a time-varying
fluid input pressure imposed on a fluid in the continuous fluid path.

US Pat. No. 10,332,615

METHOD AND SYSTEM FOR MODEL-BASED TRACKING OF CHANGES IN AVERAGE GLYCEMIA IN DIABETES

University of Virginia Pa...

1. A computer-implemented method for providing a real-time estimate of glycosylated hemoglobin (HbA1c) of a patient from a self-monitoring blood glucose (SMBG) measurement, and tracking changes in average glycemia of said patient over time, said method comprising:receiving, by a processor, a fasting SMBG measurement from said patient;
computing, by a processor, a glycation value using said fasting SMBG measurement in a predetermined glycation equation;
outputting, by a processor, said glycation value as an initial estimate of HbA1c upon initialization of tracking of said patient's average glycemia;
updating, by a processor, said glycation value by using an updated SMBG value in said predetermined glycation equation, said updated SMBG value being based on a subsequent fasting SMBG measurement from said patient;
computing, by a processor, an updated estimate of HbA1c using said initial estimate of HbA1c and said updated glycation value in a predetermined HbA1c estimation equation; and
outputting, by a processor, said updated estimate of HbA1c to a user.

US Pat. No. 10,052,047

SYSTEM AND METHOD FOR FUNCTIONAL GAIT RE-TRAINER FOR LOWER EXTREMITY PATHOLOGY

University of Virginia Pa...

1. A gait device for rehabilitating or developing a subject's lower extremity, said device comprising:a movable belt configured for the subject to ambulate thereon;
a track disposed above said movable belt generally aligned with said movable belt;
a coupler that is configured to travel along said track and attach to the distal portion of the lower extremity of the subject while the subject is ambulating on said movable belt;
wherein said distal portion of the lower extremity includes two ankles of the subject, lower portion of the two legs of the subject, and two feet of the subject;
said track is positioned to be located between the two ankles, between the lower portion of the two legs, or between the two feet; and
said coupler is configured to apply a medial force to the distal portion of the lower extremity during the ambulation to strengthen the ankle, knee and/or hip musculature of the subject.

US Pat. No. 10,052,089

DEVICE AND METHOD FOR SAFELY EXPANDING MINIMALLY INVASIVE SURGICAL INCISIONS

University of Virginia Pa...

1. An apparatus comprising:a surgical retractor device for receiving a surgical tool, said surgical retractor device comprising:
a retraction member having a proximal portion and a distal portion, said distal portion configured for insertion through an incision in a cavity wall and into a cavity of a subject, wherein:
said cavity wall is an abdominal wall, pelvic wall, or thoracic wall, and said cavity is an abdominal cavity, a pelvic cavity, or a thoracic cavity, respectively;
said proximal portion comprising an aperture disposed in said proximal portion, said aperture configured to accommodate at least a portion of the surgical tool for insertion there through said aperture;
said distal portion comprises a first surface and a second surface, said distal portion being a tongue-like shape that when the surgical tool is passed through said aperture, said distal portion's second surface is configured to block and displace an organ in the cavity of the subject away from the surgical tool to protect the organ of the subject; and
wherein said distal portion comprises a retention guide disposed on said distal portion's first surface and wherein said retention guide has a configuration configured to receive and guide the portion of the surgical tool, which is inserted through the aperture, for a travel along the retention guide disposed on the distal portion's first surface to prevent the surgical tool from contacting the organ.
US Pat. No. 10,011,686

VISCOELASTIC SILICONE RUBBER COMPOSITIONS

UNIVERSITY OF VIRGINIA PA...

1. A cured viscoelastic silicone rubber composition comprising:(a) at least one crosslinked polyorganosiloxane;
(b) sufficient permanent crosslinks to give the composition an equilibrium shape;
(c) sufficient temporary crosslinks to give the composition a stiffness that is greater on short timescales than it is on long timescales; and
(d) at least one softening agent present in an amount sufficient to make the average lifetime of the temporary crosslink of shorter duration than the average lifetime of the temporary crosslink in the absence of the softening agent.

US Pat. No. 9,989,611

SYSTEMS AND METHODS FOR IMAGE RECONSTRUCTION USING VARIABLE-DENSITY SPIRAL TRAJECTORY

University of Virginia Pa...

1. A method for data sampling and image reconstruction, comprising:acquiring magnetic resonance data corresponding to an area of interest of a subject, wherein acquiring the magnetic resonance data comprises:
determining a two-dimensional (2D) multi-level undersampling pattern based on:
a distance, rk, between each sampling point of a plurality of sampling points in k-space and a center of the k-space, and
a probability that each of the sampling points is acquired;
determining a desired variable-density spiral trajectory based on the multi-level undersampling pattern, wherein the desired variable-density spiral trajectory has a density according to a function of rk;
generating one or more spiral gradient waveforms based on the desired variable-density trajectory;
tracing a variable-density spiral trajectory using the one or more spiral gradient waveforms; and
sub-sampling the magnetic resonance data based on the variable-density spiral trajectory; and
reconstructing, using one or more image reconstruction functions that comprise compressed sensing, one or more images of the area of interest based on the acquired magnetic resonance data.

US Pat. No. 9,987,576

FREQUENCY-BASED FILTERING OF MECHANICAL ACTUATION USING FLUIDIC DEVICE

University of Virginia Pa...

1. A method, comprising:actuating a mechanical input to a closed fluidic filter network, the fluidic filter network comprising respective branches fluidically coupling the mechanical input to respective deformable mechanical outputs of the fluidic filter network, the respective deformable mechanical outputs located on an exterior surface of the fluidic filter network;
selectively transmitting a mechanical displacement from a selected deformable mechanical output of the fluidic filter network to a deformable mechanical input of a microfluidic device, the microfluidic device positioned on the exterior surface of the fluidic filter network;
controlling a fluid flow in a portion of the microfluidic device using the transmitted displacement;
wherein the selected deformable mechanical output is selected at least in part by actuating the mechanical input to produce a displacement having energy in a specified range of frequencies; and
wherein the fluidic filter network is fluidically isolated from the microfluidic device.

US Pat. No. 9,921,037

HYBRID PERIODIC CELLULAR MATERIAL STRUCTURES, SYSTEMS, AND METHODS FOR BLAST AND BALLISTIC PROTECTION

University of Virginia Pa...

1. A sandwich structure for supporting loads, mitigating blast pressure, and resisting projectile penetration, said structure
comprising:
a) a core, wherein said core comprises:
a first open-cell lattice structure layer,
a second open-cell lattice structure layer, and
an intermediate panel disposed between said first open-cell lattice structure layer and said second open-cell lattice structure
layer;

b) a first layer panel in mechanical communication with said first open-cell lattice structure layer distal from said second
open-cell lattice structure layer;

c) a second layer panel in mechanical communication with said second open-cell lattice structure layer distal from said first
open-cell lattice structure layer;

d) a plurality of elongated interstitial housings that continuously span across a full length of at least one of said first
open-cell lattice structure or said second open-cell lattice structure, wherein said interstitial housings conform to voids
in said open cells of said open-cell lattice structures such that said interstitial housings substantially fill said voids,
and wherein said plurality of elongated interstitial housings are arranged to be in parallel with each other; and

e) a filler portion disposed in any spaces between said interstitial housings and open cells of said open-cell lattice structures;
and in voids created by said open cells of said open-cell lattice structures.

US Pat. No. 9,874,623

SYSTEMS AND METHODS FOR REGULARIZED RECONSTRUCTIONS IN MRI USING SIDE INFORMATION

University of Virginia Pa...

1. A method comprising:
obtaining a first magnetic resonance (MRI) image using hydrogen (1H);
obtaining a second MRI image using a secondary nucleus other than hydrogen; and
reconstructing the second image using side information from the first image, wherein reconstructing the second image comprises
regularizing the image using a quadratic roughness penalty, and wherein the quadratic roughness penalty comprises a differencing
matrix and a plurality of weights.

US Pat. No. 9,874,566

COMPOSITIONS AND METHODS FOR MAKING AND USING OXYGEN SENSING NANOFIBERS AND SCAFFOLDS

University of Virginia Pa...

1. A dual layered scaffold for measuring oxygen levels in tissues or cells, said dual layered scaffold comprising an electrospun
boron dye-polymer conjugate nanofiber layer and an electrospun structural support nanofiber layer, wherein said polymer is
poly(lactic acid) (PLA), wherein difluoroboron dibenzoylmethane (BF2dbmOH) or iodide substituted difluoroboron dibenzoylmethane (BF2dbm(I)OH) are used to prepare said boron dye-polymer conjugate, wherein said electrospun structural support layer comprises
poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and polycaprolactone (PCL), wherein the boron dye emits a phosphorescence
signal and a fluorescence signal and the ratio of the signals is dependent on the oxygen levels present.

US Pat. No. 9,770,349

NANOPOROUS STENTS WITH ENHANCED CELLULAR ADHESION AND REDUCED NEOINTIMAL FORMATION

University of Virginia Pa...

1. A stent for insertion into a body, the stent comprising a metal stent having a dealloyed porous surface, wherein the stent
with only the porous surface and devoid of a therapeutic agent exhibits reduced neointimal formation compared to a bare metal
stent having the same configuration as the metal stent and lacking the porous surface.
US Pat. No. 9,701,714

COMPOSITIONS AND METHODS FOR REGULATING ARTERIAL TONE

University of Virginia Pa...

1. A peptide consisting of amino acid sequence LSFPTTKTYFPHFDLSHGSA (SEQ ID NO:1) or a peptide consisting of amino acid sequence
LSFPTTKTYF (SEQ ID NO:2), said peptide further comprising a plasma membrane permeability sequence.

US Pat. No. 9,640,369

COAXIAL HOLLOW CATHODE PLASMA ASSISTED DIRECTED VAPOR DEPOSITION AND RELATED METHOD THEREOF

University of Virginia Pa...

1. An apparatus for applying at least one coating onto at least one substrate, said apparatus comprising:
a deposition chamber,
at least one evaporant source,
at least one energetic beam for impinging said evaporant source forming a vapor plume,
at least two hollow cathodes aligned at least substantially coaxially with said at least one evaporant source for delivering
a discharge current, and wherein said apparatus is configured wherein said at least one evaporant source is disposed outside
said at least two hollow cathodes,

at least one plasma-forming gas emitted from each of said at least two hollow cathodes,
at least one anode for electrostatically attracting said discharge current from at least one of said two hollow cathodes,
and

wherein a) said plasma jet at least partially shapes said vapor plume b) said plasma jet at least partially entrains said
vapor plume and at least partially assists in transporting said vapor plume to said substrate to provide said at least one
coating onto said substrate.

US Pat. No. 9,211,405

ELECTRODE CATHETER FOR ABLATION PURPOSES AND RELATED METHOD THEREOF

UNIVERSITY OF VIRGINIA PA...

1. A device, comprising:
an energy source;
an endocardial ablation catheter electrically connected to the energy source and configured to be disposed in a heart and
to transmit energy received from the energy source for ablating a portion of the heart;

an electrode catheter configured to be disposed in the middle mediastinum of the thorax of a subject and configured for use
with the endocardial ablation catheter, said electrode catheter comprising:

a proximal portion, a distal portion, and a longitudinal structure there between;
at least one distal fluid aperture adapted for passage of a fluid; and
an electrode in communication with said electrode catheter,
wherein said electrode is configured to receive the transmitted energy from the endocardial ablation catheter, and
wherein said electrode catheter is configured to be placed outside of the heart, and to receive the transmitted energy from
the endocardial ablation catheter via said electrode while the endocardial ablation catheter is disposed inside of the heart.

US Pat. No. 10,256,906

POSITION LOCALIZATION USING VISIBLE LIGHT COMMUNICATION

University of Virginia Pa...

1. A system, comprising:an optical transmitter circuit, the optical transmitter configured to modulate light provided by an optical emitter to provide an optical communication signal;
a receiver circuit configured to receive information indicative of a measured characteristic of the light emitted from the optical emitter, the measured characteristic obtained from a user equipment (UE) device separate from the optical transmitter;
a location determination circuit comprising a memory circuit and a processor circuit, the memory circuit including information indicative of a fingerprint map of a region containing the UE device, the memory circuit comprising instructions that, when executed by the processor circuit, cause the location determination circuit to estimate, using a Bayesian estimator, a spatial location of the UE device within the region using the fingerprint map and the measured characteristic obtained from the user device;
wherein the measured characteristic is provided as an input to the Bayesian estimator without requiring conversion of the input into a spatial representation of the measured characteristic; and
wherein the fingerprint map includes a mapping of values representing optical intensity to spatial locations within the region.

US Pat. No. 9,998,124

LOW POWER CLOCK SOURCE

UNIVERSITY OF VIRGINIA PA...

1. An apparatus, comprising:a first oscillator circuit including a first oscillator output, the first oscillator circuit having a first power consumption level and a first stability characteristic;
a second oscillator circuit including a configuration input, a field effect transistor (FET) biased in an off-state and a second oscillator output, the second oscillator circuit having a second power consumption level and a second stability characteristic,
the first stability characteristic indicating an enhanced stability over the second stability characteristic, and the first power consumption level being greater than the second power consumption level; and
a comparator circuit including a first comparator input and a second comparator input respectively controllably coupleable to the first oscillator output and the second oscillator output;
the second oscillator circuit being configured to adjust, using the configuration input, a second oscillator output signal from the second oscillator output based on, at least in part, (1) a leakage of the FET biased in the off-state and (2) information obtained from the comparator circuit about a comparison between a first oscillator output signal from the first oscillator output and the second oscillator output signal so as to maintain an operational stability substantially comparable to the first stability characteristic at the second power consumption level.

US Pat. No. 9,926,290

INHIBITORS OF INV(16) LEUKEMIA

University of Virginia Pa...

1. A compound selected from the group consisting of:

US Pat. No. 9,698,685

METHODS AND APPARATUS FOR A SINGLE INDUCTOR MULTIPLE OUTPUT (SIMO) DC-DC CONVERTER CIRCUIT

UNIVERSITY OF VIRGINIA PA...

1. An apparatus, comprising:
a single-inductor multiple-output (SIMO) DC-DC converter circuit, the SIMO DC-DC converter circuit having a plurality of output
nodes; and

a panoptic dynamic voltage scaling (PDVS) circuit operatively coupled to the SIMO DC-DC converter circuit, the PDVS circuit
having a plurality of operational blocks, each operational block from the plurality of operational blocks drawing power from
one supply voltage rail from a plurality of supply voltage rails, each output node from the plurality of output nodes being
uniquely associated with a supply voltage rail from the plurality of supply voltage rails.

US Pat. No. 9,237,898

SYSTEMS AND METHODS FOR ULTRASOUND IMAGING AND INSONATION OF MICROBUBBLES

University of Virginia Pa...

1. A catheter system comprising:
an elongate tubular member having a proximal end portion, a distal end portion and a lumen extending through at least a portion
of a length of said elongate tubular member, said distal end portion dimensioned and adapted to advance to or in proximity
to a treatment site of a subject;

a microbubble device in fluid communication with said lumen, said microbubble device including at least one input port for
receiving a flow of material into said device and an output port configured to output microbubbles from said microbubble device;

a second tubular member in fluid communication with one of said at least one input ports; and
a pressure fitting arrangement adapted to maintain a seal between said second tubular member and said input port;
wherein said pressure fitting arrangement comprises an elongated insertion recess in said port;
wherein said elongated insertion recess has a width greater than an outside diameter of said second tubular member and said
elongated insertion recess has a height less than said outside diameter of said second tubular member; and

wherein said pressure fitting arrangement comprises a macro chamber surrounding said microbubble device except for said output
port, said macro chamber configured to be pressurized internally to an internal pressure greater than a pressure outside of
said macro chamber.

US Pat. No. 9,885,652

MINIATURIZED MULTIWELL PLATE READER FOR PHENOTYPIC SCREENING

University of Virginia Pa...

1. A multi-well plate reader, comprising:
an emitter assembly including a plurality of electromagnetic emitters mounted to a first alignment plate and oriented to transmit
electromagnetic radiation through a first window defined by the first alignment plate;

a receptor assembly including a plurality of receptors mounted to a second alignment plate and oriented to receive electromagnetic
radiation through a second window defined by the second alignment plate;

a spacer element separating and positioning the emitter assembly to the receptor assembly to define a plate slot for receiving
a multi-well plate between the first alignment plate and the second alignment plate and align the multi-well plate with the
first and second windows,

a microprocessor operably coupled to one of the first alignment plate and the second alignment plate and operably linked to
each receptor; and

a footing element extending from at least one of the first alignment plate and the second alignment plate, the footing element
comprising a coupling element is configured to couple the multi-well plate to at least one of a structural feature within
an incubation chamber of an incubator or a second multi-well plate reader;

wherein each electromagnetic emitter is operable to transmit electromagnetic radiation at a predetermined intensity to one
receptor of the plurality of receptors along a generally linear optical path through the first window, traversing the plate
slot, and through the second window, wherein the microprocessor operably coupled to one of the first alignment plate and the
second alignment plate and is programmed to determine real time growth of a biological sample in the multi-well plate during
incubation of the multi-well plate within the plate slot by evaluating changes between at least two received intensity values
measured by the corresponding receptor.

US Pat. No. 9,986,910

INTUITIVE TECHNIQUES AND APPARATUS FOR OPHTHALMIC IMAGING

University of Virginia Pa...

1. An optical apparatus, comprising:an optical lens system configured to relay an image of an anatomical target to an image acquisition assembly via an optical imaging path provided by the optical lens system, the optical lens system including:
an objective lens configured to be located near the anatomical target; and
an alignment assembly configured to be user-positionable at least partially in the optical imaging path;
wherein an image presented via the optical imaging path includes a first field of view to provide an image of an anatomical landmark when the alignment assembly is included at least partially in the optical imaging path, and a second field of view to provide the image of the anatomical target when the alignment assembly is substantially excluded from the optical imaging path;
wherein a focusing target is produced by the optical lens system and is presented to the image acquisition assembly without use of a prismatic focusing aid;
wherein the image acquisition assembly comprises a digital camera configured to automatically obtain a focus on a desired portion of the anatomical target using a reflection of the focusing target relayed to the image acquisition assembly via the optical lens system without using a prismatic focusing aid; and
wherein, the optical apparatus is configured to automatically perform at least one of repositioning the alignment assembly, enabling a projection of the focusing target onto the anatomical target for at least a specified duration during which the digital camera obtains focus, or disabling projection of the focusing target after the digital camera obtains focus.

US Pat. No. 9,989,497

FRONT END CIRCUITRY WITH ANALOG SAMPLING AND DECODING FOR ULTRASOUND IMAGING SYSTEMS AND METHODS OF USE

University of Virginia Pa...

1. A pulse-echo imaging system comprising:a pulse generation circuit configured to provide electrical signals representative of a transmit code sequence;
a transducer configured to receive the electrical signals provided by the pulse generation circuit as pulses using coded excitation according to said transmit code sequence, and to transduce said electrical signals to pulses of energy other than electrical signals; said transducer being further configured to receive echoes of said pulses of energy other than electrical signals and convert the echoes to received electrical signals; and
a receive circuit configured to:
receive said received electrical signals;
perform analog sampling of the received electrical signals;
perform analog decoding of the received electrical signals using information about the coded excitation and using an analog decoder circuit; and
provide a weighted, summed digital signal using information obtained from the analog sampling and the analog decoding;
processing circuit configured to;
receive weighted sum digital signal; and
generate image using the digital signal;
display coupled to processing circuit to display the image.

US Pat. No. 9,891,165

CHIRPED PULSE FREQUENCY-DOMAIN COMB FOR SPECTROSCOPY

University of Virginia Pa...

1. A method, comprising:
generating a pulse train comprising phase-coherent frequency-chirped pulses of at least one of microwave, millimeter-wave,
or sub-millimeter wave electromagnetic energy;

applying a time-domain window to at least one frequency-chirped pulse in the pulse train; and
exciting a sample using the pulse train.

US Pat. No. 9,636,487

METERS FOR IN-VIVO MONITORING

University of Virginia Pa...

1. An apparatus for use in monitoring treatment of hydrocephalus, comprising:
an implantable shunt;
a meter including one or more microfluidic channels connected to the shunt and configured to detect at least one of pressure
and fluid flow rate through the shunt and to be read out remotely by a wirelessly coupled external device,

the meter further includes a plurality of volumetric reservoirs in fluid communication with the one or more microfluidic channels,
each of the plurality of reservoirs having different dimensions and configured as separate passive resonant tank (LC) circuits.

US Pat. No. 10,227,924

PARTICLE SEPARATOR

Rolls-Royce North America...

1. An air-inlet duct for a gas-turbine engine, the air-inlet duct comprisingan outer wall spaced apart from an engine rotation axis,
an inner wall located between the outer wall and the engine rotation axis, the inner wall and the outer wall defining an air-inlet passageway therebetween,
a splitter located between the outer wall and the inner wall and including an outer splitter surface cooperating with the outer wall to define a scavenge channel therebetween and an inner splitter surface cooperating with the inner wall to define an engine channel therebetween, and
a flow regulator configured to regulate a portion of an inlet flow including particles to cause a size and duration of a separated flow region formed along the outer wall and upstream of a scavenge inlet to the scavenge channel to be minimized so that the particles are collected in the scavenge channel and an amount of particles entering the engine channel are minimized,
wherein the flow regulator includes a series of flow control devices, each flow control device coupled to the outer wall to extend radially inward from the outer wall, and terminating at a free end exterior to the engine rotation axis and the inner wall, and each flow control device has a pair of parallel sides and is arranged to lie in spaced-apart circumferential relation to one another and located upstream of the separated flow region.

US Pat. No. 9,979,348

LOW VOLTAGE CRYSTAL OSCILLATOR (XTAL) DRIVER WITH FEEDBACK CONTROLLED DUTY CYCLING FOR ULTRA LOW POWER

UNIVERSITY OF VIRGINIA PA...

1. An apparatus, comprising:a crystal oscillator (XTAL) driver having an amplifier with metal-oxide-semiconductor (MOS) transistors, the XTAL driver configured to produce an operating signal to operate a XTAL while the MOS transistors are operated at a sub-threshold operating regime;
the XTAL driver configured to adjust effective lengths of the MOS transistors based on a comparison of an output of the XTAL driver and a voltage reference such that a value of a negative resistance of the amplifier of the XTAL driver is adjusted for operation of the MOS transistors at the sub-threshold operating regime.

US Pat. No. 10,310,047

SYSTEMS AND METHODS FOR FREE-BREATHING CINE DENSE MRI USING SELF-NAVIGATION

University of Virginia Pa...

1. A method comprising:acquiring magnetic resonance data for an area of interest of a subject, wherein the acquiring comprises performing sampling with phase-cycled, cine displacement encoding with stimulated echoes (DENSE) during free-breathing of the subject;
identifying, from the acquired magnetic resonance data, a plurality of phase-cycling data pairs corresponding to matched respiratory phases of the free-breathing of the subject;
reconstructing, from the plurality of phase-cycling data pairs, a plurality of intermediate self-navigation images of the area of interest of the subject;
performing motion correction by estimating, from the plurality of intermediate self-navigation images, the respiratory position associated with the plurality of phase-cycling data pairs; and
reconstructing a plurality of motion-corrected cine DENSE images of the area of interest of the subject.

US Pat. No. 10,107,744

FREQUENCY HOPPING SPREAD SPECTRUM (FHSS) FOURIER TRANSFORM SPECTROSCOPY

University of Virginia Pa...

1. An apparatus, including:a pattern generator circuit configured to output a pulse sequence, the pulse sequence including durations during which frequencies selected from a first frequency range are output, including a count N of different frequencies output serially within the pulse sequence, the pulse sequence further comprising a count M of unique permutations of an order in which the count N of different frequencies are output, the count N being at least three;
a frequency multiplier circuit operably coupled to the pattern generator circuit and configured to upconvert the pulse sequence to an upconverted pulse sequence having a higher second range of frequencies beyond the first range of frequencies;
a sample cell in electromagnetic communication with the frequency multiplier circuit and configured to receive the upconverted pulse sequence as an excitation to a sample; and
an analog-to-digital converter configured to acquire a digital representation of an output from the sample cell elicited in response to the upconverted pulse sequence.

US Pat. No. 10,131,086

MICRO-STRUCTURE AND NANO-STRUCTURE REPLICATION METHODS AND ARTICLE OF MANUFACTURE

University of Virginia Pa...

1. A method for replicating at least one textured surface, said method comprising the following steps:providing at least one master having at least one textured surface with microtexture cones, wherein said microtextured cones of said at least one master includes nanoscale features on surfaces of said microtexture cones of said at least one master;
providing at least one substrate;
providing at least one replicating material, wherein said at least one replicating material is in communication with said at least one substrate;
placing said at least one textured surface of said at least one master in contact with said at least one replicating material;
applying an embossing force to the combination of said at least one master, said at least one replicating material, and said at least one substrate;
heating at least one of said at least one master, said at least one replicating material, and said at least one substrate;
reducing or eliminating said heating;
removing said embossing force;
separating said at least one master from said at least one replicating material to provide a replica of said at least one textured surface with microtexture cones of said at least one master, wherein said microtexture cones of said replica includes nanoscale features on surfaces of said microtexture cones of said replica, wherein said nanoscale features of said replica are the result of correctly replicating said at least one master;
wherein said separating step directly provides said replica without any additional processing steps to accomplish said replica, and wherein said surface of said replica is superhydrophobic.

US Pat. No. 10,126,438

SYSTEMS AND METHODS FOR POLARIZED NUCLEAR IMAGING AND SPECTROSCOPY

UNIVERSITY OF VIRGINIA PA...

1. A method for examining a subject, comprising:polarizing nuclei of a radioactive substance such that the spins of the nuclei are oriented in a specific direction, to generate a polarized radioactive tracer with anisotropic gamma ray emission probability;
introducing the tracer into a subject;
applying at least one of radio frequency oscillating (RF) magnetic fields and spatially varying magnetic fields to the tracer in the subject that are configured to manipulate the orientation of the spins such as to manipulate the directional dependence of anisotropic gamma ray emission from the tracerin the subject;
detecting gamma rays from the gamma ray emission; and
obtaining, based on the detected gamma rays and properties associated with the gamma ray emission, at least one of imaging data and spectroscopic data associated with the tracer in the subject wherein the applying of at least one of radio frequency oscillating (RF) magnetic fields and spatially varying magnetic fields to the tracer in the subject includes applying the at least one of radio frequency oscillating (RF) magnetic fields and spatially varying magnetic fields to the tracer in the subject prior to the detecting of gamma rays from the gamma ray emission.

US Pat. No. 9,942,262

CYBER-PHYSICAL SYSTEM DEFENSE

University of Virginia Pa...

1. A system for cyber-physical system defense, the system comprising:a sensor interface to receive sensor data from a plurality of sensors;
a sampling circuit set to sample sensor disagreements between the plurality of sensors over time;
a cluster circuit set to perform cluster analysis on the sampled sensor disagreements including the cluster circuit set to perform a cluster analysis algorithm to calculate a time period and determine whether a predetermined number of the sampled sensor disagreements occurred within the calculated time period, wherein the calculated time period is calculated via an inverse Gamma function with a probability parameter, a sample-size parameter, and a time-of-arrival parameter, the time-of-arrival parameter determined via measurement of a sensor system during normative testing; and
an alert circuit set to provide a deviation indication in response to the cluster analysis resulting in disagreement density beyond a threshold, the deviation indication including an alarm.
US Pat. No. 10,253,069

COMPOSITIONS AND METHODS FOR REGULATING ARTERIAL TONE

University of Virginia Pa...

1. A method to treat a disease or condition comprising administering to a subject in need thereof a pharmaceutical composition comprising a physiologically acceptable carrier and an effective amount of:a) a peptide consisting of amino acid sequence LSFPTTKTYFPHFDLSHGSA (SEQ ID NO:1); or
b) a peptide consisting of amino acid sequence LSFPTTKTYF (SEQ ID NO:2),
and said peptide further comprises a plasma membrane permeability sequence, wherein said method increases nitric oxide, inhibits or reduces vasoconstriction, regulates blood pressure, or relaxes resistance arterioles, so as to treat said condition or disease.
US Pat. No. 10,363,299

COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING RHINOVIRUS INFECTIONS

UNIVERSITY OF VIRGINIA PA...

1. A method for inducing an immune response against a rhinovirus (RV) or for activating antigen-experienced RV-specific CD4+ T cells in a subject, said method comprising administering to said subject a pharmaceutical composition comprising an effective amount of at least one RV peptide epitope, wherein at least one of said RV peptide epitopes is a conserved RV peptide epitope recognized by antigen-experienced RV-specific CD4+ T cells, wherein said at least one RV peptide epitope is selected from the group consisting of SEQ ID NOs:1-53, 56, and 57, and biologically active fragments and homologs of said at least one RV peptide epitope.

US Pat. No. 10,308,663

INHIBITORS OF PTP4A3 FOR THE TREATMENT OF CANCER

University of Virginia Pa...

4. A method for treating a subject suffering from cancer, the method comprising administering to the subject a therapeutically effective amount of a compound according to Formula III or a pharmaceutically acceptable salt thereof:whereinR4 is selected from the group consisting of H, —OH, —OC1-4 alkyl, —ORa, trifluoroC1-4 alkoxy, —SC1-4 alkyl, —SRa, —SO2—C1-4 alkyl, —SO2Ra, —SOC1-4 alkyl, —SORa, —SO2NHRb, —NRCRd, halo, —C1-12 alkyl, —C2-6 alkenyl, —C2-6 alkynyl, —C3-6 cycloalkyl, phenyl, benzyl, monocyclic heteroaryl optionally substituted with Rb, C4-7 heterocycloalkyl containing one or two of O, S, and N, —OC(O)Rb, —OC(O)Rb, —P(O)(ORb)1-2, —P(S)(ORb)1-2, —P(O)(NRCRd)1-2, —P(S)(NRCRd)1-2, —O(CH2—CH2—O)1-4CH3, —CN, —NO2, —C(O)C1-4 alkyl, and —C(O)—Rb,
Ra is selected from the group consisting of —C3-6 cycloalkyl, —C2-6 alkenyl, —C2-6 alkynyl, phenyl, benzyl, and monocyclic heteroaryl, wherein the phenyl, benzyl, or monocyclic heteroaryl is optionally substituted with Rb;
Rb in each instance is independently selected from the group consisting of H, halo, —OH, —COOH, —C1-12 alkyl, phenyl, benzyl, and monocyclic heteroaryl, wherein the phenyl, benzyl, or monocyclic heteroaryl is optionally substituted with —C2-6 alkenyl, —C2-6 alkynyl, trifluoroC1-4 alkoxy, —OC1-4 alkyl, —O(CH2—CH2—O)1-4 CH3, —O-phenyl, —O-benzyl, —NC1-4 alkyl, —N-phenyl, and —N-benzyl, or —N-monocyclic heteroaryl;
RC and Rd are each independently selected from the group consisting of H, —C1-4 alkyl, —C(O)—C1-4 alkyl, —SO2—Ra, —SO2—C1-4 alkyl, phenyl, benzyl, and monocyclic heteroaryl, wherein the phenyl, benzyl, or monocyclic heteroaryl is optionally substituted with Rb,
or RC and Rd taken together with the nitrogen to which they are attached represent an optionally substituted monocyclic heterocycloalkyl containing one or more of O, S, and N.

US Pat. No. 10,159,464

SEPARABLE BEAMFORMING FOR ULTRASOUND ARRAY

University of Virginia Pa...

1. An ultrasonic imaging system for use with an ultrasonic transducer array, the ultrasonic transducer array including transducer elements arranged in a two-dimensional array defining a transducer plane and configured to insonify a tissue region with ultrasonic energy, the system comprising a processor circuit coupled to a memory circuit, the memory circuit comprising instructions that, when performed by the processor circuit, cause the processor circuit to:obtain, from the ultrasonic transducer array, information indicative of the reflected ultrasonic energy; and
construct a representation of an imaging plane, within the tissue region, including using the obtained information indicative of the reflected ultrasonic energy including:
separately determining, for respective focusing locations in an imaging plane including a specified focusing location, respective first sums of samples of reflected ultrasonic energy obtained via respective first lines of transducers in the ultrasonic transducer array, the samples obtained via respective first lines of transducers corresponding to respective orthogonal projections of the respective focusing locations in the imaging plane onto the respective first lines in the transducer plane; and
separately determining, for the specified focusing location in the imaging plane, a second sum of at least some of the respective first sums of samples of reflected ultrasonic energy, the second sum corresponding to a second line of transducers in the ultrasonic transducer array, the second line of transducers aligned along an axis different from an axis of the respective first lines in the transducer plane and corresponding to the orthogonal projection of the specified focusing location in the imaging plane onto the transducer plane.
US Pat. No. 10,393,755

COMPOSITIONS AND METHODS FOR TREATING EYE INFECTIONS AND DISEASE

University of Virginia Pa...

1. A sterile, aqueous pharmaceutical composition for topical administration to an ocular surface, the composition comprising:a peptide, or a pharmaceutically acceptable salt thereof,
wherein the peptide, or a pharmaceutically acceptable salt thereof, has an amino acid sequence consisting of SEQ ID NO: 5,
wherein the C-terminus of the peptide is amidated,
wherein the N-terminus of the peptide is acetylated, and a pharmaceutically acceptable aqueous carrier,
wherein the sterile, aqueous pharmaceutical composition is suitable for topical administration to an ocular surface of a subject, and
wherein the sterile, aqueous pharmaceutical composition is free of any type of enzymatic, chemical or biochemical molecule capable of breakdown of the peptide at its termini that is sequential degradation of the peptide at a terminal end thereof in the absence of the C-terminus amidation and the N-terminus acetylation.

US Pat. No. 10,340,972

ULTRA LOW POWER SENSING PLATFORM WITH MULTIMODAL RADIOS

University of Virginia Pa...

1. An apparatus, comprising:a system on chip (SoC) having a first memory circuit portion and a second memory circuit portion, the first memory circuit portion configured to operate at a subthreshold voltage that establishes subthreshold operation of one or more field effect transistors associated with the first memory circuit portion, the subthreshold operation including conduction of current by the one or more field effect transistors, the second memory circuit portion configured to operate at a superthreshold voltage,
the SoC configured to access the second memory circuit portion in response to at least one of (1) signals being sent from the SoC, or (2) signals being received at the SoC.

US Pat. No. 10,240,816

SMART WATER HEATER SYSTEM, METHOD AND COMPUTER READABLE MEDIA

University of Virginia Pa...

16. The method of claim 15, wherein the controller determines a probability of a short event and when the probability is greater than a short event threshold set point the controller adjusts the mixing of the cold water and hot water such that no hot water is directed to the domestic water system.

US Pat. No. 10,201,947

METHOD OF FORMING A SPECTRAL SELECTIVE COATING

University of Virginia Pa...

10. A spectral selective coating, comprising:a substrate; and
a sintered layer disposed on the substrate, the sintered layer being formed of particles sintered under atmospheric pressure, wherein:
the particles include submicron particles; and
the sintered layer is textured and has a submicron surface roughness height on the sintered layer.

US Pat. No. 10,193,927

METHOD OF INSTRUCTION LOCATION RANDOMIZATION (ILR) AND RELATED SYSTEM

University of Virginia Pa...

1. A system for computer security that defines a specification for relocating arbitrarily sized blocks of computer instructions included in a computer code to arbitrary locations, said system comprising:an input module configured to receive blocks of instructions, said blocks of instructions being of an arbitrarily-selectable size;
a microprocessor configured to define in a specification how to relocate said blocks of instructions to arbitrary locations; and
an output module configured to transmit the specification,
wherein the specification is configured to determine the arbitrary locations to which the blocks of instructions will be moved based at least in part on a randomization function,
wherein said microprocessor is further configured to determine the size of said blocks based at least in part on another randomization function, and to identify indirect branch targets among said blocks of instructions,
wherein the specification includes rules for relocating all of the identified indirect branch targets to randomized locations, and rules for modifying a call instruction for an original address of at least one of the indirect branch targets so that the call instruction is directed to the randomized location for the at least one of the indirect branch targets, and
wherein the relocation may occur according to the specification that defines how to perform the relocation, the relocated blocks of instructions may be re-relocated at any time, and the re-relocation may include only a portion of the blocks of instructions.

US Pat. No. 10,172,639

DEVICES AND METHODS FOR PROTECTING AN INTERNAL CHANNEL OF A SUBJECT

UNIVERSITY OF VIRGINIA PA...

1. A device for protecting an internal channel of a subject, comprising:a first end portion having a first diameter and defining a first opening;
a second end portion, opposite the first end portion, having a second diameter that is less than the first diameter and defining a second opening that is in communication with the first opening; and
a body portion defined between the first end portion and second end portion and defining an interior passage between the first opening and second opening, wherein the body portion is configured to expand in a longitudinal direction from a collapsed state to an expanded state to extend in length, wherein the second diameter is less than the first diameter when the body portion is in the expanded state and the second end portion is at least partially inside the internal channel of the subject, wherein the internal channel of the subject corresponds to a nasal passage of the subject, and
wherein the second end portion is configured to selectively engage an instrument for pushing the second end portion into the internal channel of the subject to expand the body portion in the longitudinal direction from the collapsed state to the expanded state such that the first end portion extends at least partially outside of an opening to the internal channel of the subject and the second end portion is at least partially inside the internal channel of the subject.

US Pat. No. 10,176,324

SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR PROTECTING SOFTWARE VIA CONTINUOUS ANTI-TAMPERING AND OBFUSCATION TRANSFORMS

University of Virginia Pa...

1. A computer method of increasing the tamper-resistance and/or obscurity of computer software code, said method comprising:one or more first preparation transformations;
preparing, by a computer processor, designated computer software code for execution in a designated execution environment by applying the one or more first preparation transformations, wherein said preparation makes it difficult to execute the designated computer software code independently from the designated execution environment, the designated software code being inextricably tied to the designated execution environment;
one or more second preparation transformations;
preparing, by the computer processor, the designated execution environment by applying the one or more second preparation transformations, wherein the one or more second preparation transformations allow only the designated computer software code to execute within the designated execution environment;
one or more execution transformations; and
applying, by the computer processor, the one or more execution transformations during execution of the designated computer software code, wherein the one or more execution transformations are applied to the designated computer software code and to the designated execution environment,
wherein said designated execution environment comprises at least one of: software dynamic translation (SDT), virtual machine (VM), Java VM, Strata VM, program simulators, program emulators, and virtualization systems.

US Pat. No. 10,159,782

METHOD AND SYSTEM FOR ENHANCED IMAGING VISUALIZATION OF DEEP BRAIN ANATOMY USING INFUSION

University of Virginia Pa...

1. A catheter system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system, said catheter system comprising:a catheter device including a first lumen, said first lumen having a first lumen proximal region, a first lumen distal region, and a first lumen longitudinal region there between;
said first lumen configured to convey a diagnostic agent within said first lumen, and at least a portion of said first lumen having one or more ports configured to allow the conveyed diagnostic agent to exit from said first lumen to at least a portion of the brain site; and
wherein a portion of said catheter device having a cross-sectional area greater than portions of said catheter located proximally therefrom is configured to define a seal within at least a portion of the brain site to prevent the exited diagnostic agent from travelling proximally beyond the seal while at least a portion of the brain site can be visualized on a medical imaging system, and wherein the exited diagnostic agent exits distally beyond the seal through the one or more ports, wherein the one or more ports comprise a circumferentially arranged array of holes extending along a length of the first lumen distal region, distally beyond the seal.

US Pat. No. 10,159,619

HIP CONTINUOUS PASSIVE MOTION DEVICE AND RELATED METHODS

University of Virginia Pa...

1. A system for moving a subject's upper leg configured to apply a moment of force to the subject's upper leg, said system comprising:a retention surface, said retention surface generally having a width to define a retention surface lateral direction and a length to define a retention surface longitudinal direction;
a leg support member generally having a width to define a leg support lateral direction and a length to define a leg support longitudinal direction; wherein the leg support member longitudinal direction is offset at an angle laterally from the retention surface longitudinal direction;
said leg support member configured to be able to support the subject's leg during movement of said leg support member;
said retention surface being configured to be able to support the subject on said retention surface; and
an actuator in communication with said leg support member to provide the movement of the leg support member, wherein the movement of the leg support member:
is aligned with the leg support longitudinal direction and offset from the retention surface longitudinal direction, and
generates said moment of force to the leg support member to displace leg support member about the location of the subject's corresponding hip relative to said retention surface to define a retention surface-hip location so as to allow the leg support member to move posterior and anterior to a plane of the retention surface thereby providing for both extension and flexion of said leg support member relative to said retention surface-hip location.

US Pat. No. 10,401,327

SYSTEMS AND METHODS FOR MULTISPECTRAL PHOTOACOUSTIC MICROSCOPY

UNIVERSITY OF VIRGINIA PA...

1. A reflection-mode multispectral photoacoustic microscopy (PAM) system, comprising:a reflective microscope objective;
an ultrasonic transducer attached to a primary reflective surface of the reflective microscope objective, wherein a plurality of optical paths are formed between the primary reflective surface and a plurality of internally positioned reflective surfaces, and wherein the primary reflective surface is a hemispherical mirror coated with ultraviolet enhanced material configured to cause an obscuration of one of the optical paths formed between the primary reflective surface and a center of an incoming optical path of an optical system; and
an optical and acoustic foci positioned opposite the internally positioned reflective surfaces, wherein an acoustic path is formed between the ultrasonic transducer and the optical and acoustic foci.
US Pat. No. 10,302,658

COMPOSITIONS AND METHODS FOR TREATING EYE INFECTIONS AND DISEASE

University of Virginia Pa...

1. A method comprising determining the concentration of 90 kDa deglycanated syndecan-1 (SDC-1) in a tear sample and determining if a decreased level of 90 kDa deglycanated SDC-1 is present in the sample relative to a predetermined standard, and/or detecting the presence of 25 kDa SDC-1 in a tear sample.
US Pat. No. 10,292,989

GENERAL ANESTHETICS THAT ARE NOT NEUROTOXIC

University of Virginia Pa...

1. A method for anesthetizing a pediatric subject and reducing the risk of neurotoxicity and of impairing developmental synaptogenesis associated with a neurotoxic general anesthetic, said method comprising administering to said subject an effective amount of a neuroactive steroid analgesic, wherein said neuroactive steroid analgesic has reduced neurotoxicity compared to said neurotoxic general anesthetic, wherein said neuroactive steroid analgesic is (3?,5?,17?)-3-hydroxyandrostane-17-carbonitrile (3?-OH) and is administered at a dose ranging from about 5 mg/kg/body weight to about 25 mg/kg body weight, thereby anesthetizing said subject and reducing the risk of neurotoxicity and of impairing developmental synaptogenesis associated with said neurotoxic general anesthetic.