US Pat. No. 9,198,949

METHOD AND PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF CANCER

INSERM (INSTITUT NATIONAL...

1. A soluble peptide of formula (II):

US Pat. No. 10,510,439

SYSTEM AND METHOD FOR PROCESSING HEALTHCARE INFORMATION

UPMC, Pittsburgh, PA (US...

1. An apparatus programmed for processing healthcare information, the apparatus comprising:an electronic computer processor;
an electronic screen display operatively associated with the processor, the processor programmed for:
displaying data associated with a patient on the screen display, and
navigating from a first screen to a second screen displayed on the screen display, wherein only one screen is visible on the screen display at any point in time, in response to receiving a manual swipe on the screen display from a user; and
the processor further programmed to:
receive data from across multiple computer systems containing information associated with the selected patient data,
capture data associated with multiple events associated with the selected patient data from the multiple computer systems, wherein the events include a plurality of micro-events,
display on the screen display:
a list of providers associated with the selected patient data,
at least one graph representative of an interaction between two or more of the multiple computer systems and the selected patient data, wherein at least one of the interactions describes a relationship between a plurality of providers and the selected patient data,
data indicative of provider availability within a clinical situation involving provider data stored in the multiple computer systems,
a graphical representation of at least one latent tie associated with provider data contained in the multiple computer systems and the selected patient data, wherein the latent tie exists in a deactivated state until the latent tie is activated by receiving data indicating communication between or among at least a portion of the providers,
a graphical representation of at least one direct tie associated with provider data contained in the multiple computer systems and the selected patient data, wherein the direct ties and the latent ties are either permanent or transient for a period related to a specific episode of care, and
a graphical representation of at least one meta-event associated with occurrence of a plurality of the captured micro-event data,
follow across multiple communication platforms and adjust a preferred communication mode according to a currently utilized device associated with the selected patient data,
capture at least a portion of the patient data through multiple external interfaces associated with the multiple computer systems,
receive at least a portion of the patient data from at least one application specific listener programmed to translate application events to at least one of the external interfaces, and,
connect, through a load balanced web farm, to a highly available database through a database interface for accessing at least a portion of the patient data.

US Pat. No. 9,254,234

ROBOTIC STRONG ARM

The United States of Amer...

1. A robotic strong arm (RSA) for assisting in the transfer of a person from a first surface to a second surface, comprising:
first and second members, wherein each member comprises a prismatic joint having first and second ends and comprising inner
and outer shells and a motor for powered linear movement of the outer shell with respect to the inner shell;

a first powered joint interconnecting the second end of the first member with the first end of the second member, wherein
the first powered joint provides movement of the second member with respect to the first member;

wherein the first end of the first member is attached to a rotatable base and wherein the rotatable base is movably attached
for powered movement along a component associated with, and extending around at least a portion of a periphery about, the
first surface;

a computer controller for controlling movements of the outer shells, first powered joint, rotation of the rotatable base and
movement of the rotatable base and RSA along the component;

a sensor associated with one or both outer shells for sensing position information for one or both outer shells and providing
said position information to the computer controller; and

a user interface to the computer controller for inputting commands for movement of the RSA; wherein the computer controller
detects an onset of a dangerous positioning of the RSA and warns the user before and/or during said dangerous positioning
of the RSA.

US Pat. No. 9,688,767

METHOD OF PREDICTING SURVIVAL TIME IN MYOCARDIAL INFARCTION PATIENTS BY MEASURING BAFF LEVELS

Institut National de la S...

1. A method for predicting the survival time of a patient suffering from myocardial infarction or the recurrence of a myocardial
infarction in a patient who has suffered from a myocardial infarction and treating said patient, comprising the steps of
i) determining the expression level of B cell activating factor (BAFF) in a sample from said patient,
ii) comparing said expression level with a control value, wherein said control value is based on BAFF levels in a collection
of samples from patients suffering from myocardial infarction, or based on BAFF levels in a collection of samples from healthy
subjects,

iii) providing a good prognosis of the survival time or a low risk of the recurrence of a myocardial infarction when the expression
level is lower than the control value,

or providing a poor prognosis of the survival time or a high risk of the recurrence of a myocardial infarction when the expression
level is higher than the control value, and

iv) administering a therapeutically effective amount of an anti-CD20 antibody to said patient when a poor prognosis is provided
in step iii), wherein the therapeutically effective amount is sufficient to treat said patient.

US Pat. No. 9,471,747

APPARATUS AND METHOD FOR VIEWING MEDICAL INFORMATION

UPMC, Pittsburgh, PA (US...

1. An apparatus comprising:
a computer system programmed to retrieve medical data related to an individual patient from a plurality of medical data sources;
the computer system including a plurality of vault query services using a business rule configuration to create a real-time
virtual patient object for the individual patient by a singleview framework wherein the singleview framework integrates or
remove data sources without historical data migration;

an adapter for each of the data sources, each adapter translating an interface for one of the data sources to a vault query
service interface; and

a cross-vault query service providing an interface for data communication between an application program and the plurality
of vault query services; and using the real-time virtual patient object when a query is requested to query the data sources,
wherein the cross-vault query service splits the query from the application program into N independent queries, asynchronously
queries each of the medical data sources, combines medical data relating to the individual patient retrieved in response to
the independent queries, wherein the application program interacts with an Enterprise Master Patient Index through a cross-vault
query rules engine, and wherein the Enterprise Master Patient Index identifies multiple patient instances and presents a single
aggregated dataset of the medical data for the individual patient to the application program; and

a user display for displaying the medical data relating to the individual patient retrieved from the data sources in response
to the query.

US Pat. No. 10,138,278

FLUOROGEN ACTIVATING AND SHIFTING TAG (FAST)

CENTRE NATIONAL DE LA REC...

1. A a functional photoactive yellow protein (PYP) polypeptide comprising the sequence of SEQ ID NO: 48, or a sequence having at least 70% identity with the sequence of SEQ ID NO: 48, wherein said sequence further comprises one or more amino acid substitutions in the amino acid region at position 94-101 with reference to SEQ ID NO: 48, one of said substitutions being a proline at position 97 with reference to SEQ ID NO: 48, and wherein said polypeptide binds reversibly a fluorogenic chromophore with:a KD ranging from about 0.05 to about 10 ?M when measured at a temperature of about 25° C.; and/or
a koff ranging from about 1 to about 50 s?1 when measured at a temperature of about 25° C.; and/or
a kon ranging from about 0.1×107 to about 50×107 M?1s?1 when measured at a temperature of about 25° C.
US Pat. No. 10,414,768

COMPOUNDS FOR TREATING CYSTIC FIBROSIS

Centre National de la Rec...

1. A compound, selected from the group consisting of(S)-2-((2-chloro-9-(4-(hydroxymethyl)phenyl)-9H-purin-6-yl)amino)propanoic acid;
(S)-tert-butyl 2-((2-chloro-9-(4-(hydroxymethyl)phenyl)-9H-purin-6-yl)amino)propanoate;
4-(2-chloro-6-(diethylamino)-9H-purin-9-yl)benzamide;
4-(6-amino-2-chloro-9H-purin-9-yl)benzamide;
4-(2-chloro-6-((1,3-dihydroxypropan-2-yl)amino)-9H-purin-9-yl)benzamide;
(S)-2-((9-(4-carbamoylphenyl)-2-chloro-9H-purin-6-yl)amino)-3-hydroxypropanoic acid;
2-((9-(4-carbamoylphenyl)-2-chloro-9H-purin-6-yl)amino)acetic acid;
tert-butyl 2-((9-(4-carbamoylphenyl)-2-chloro-9H-purin-6-yl)amino)acetate;
4-(2-chloro-6-((4-methoxybenzyl)amino)-9H-purin-9-yl)benzamide;
(S)-2-((9-(4-carbamoylphenyl)-2-chloro-9H-purin-6-yl)amino)propanoic acid;
(S)-tert-butyl 2-((9-(4-carbamoylphenyl)-2-chloro-9H-purin-6-yl)amino)propanoate;
(4-(6-amino-2-chloro-9H-purin-9-yl)phenyl)methanol;
(S)-2-((9-(4-(hydroxymethyl)phenyl)-2-((3-phenylpropyl)amino)-9H-purin-6-yl)amino)propanoic acid; and
4-(6-((4-methoxybenzyl)amino)-2-((3-phenylpropyl)amino)-9H-purin-9-yl)benzamide.

US Pat. No. 9,471,747

APPARATUS AND METHOD FOR VIEWING MEDICAL INFORMATION

UPMC, Pittsburgh, PA (US...

1. An apparatus comprising:
a computer system programmed to retrieve medical data related to an individual patient from a plurality of medical data sources;
the computer system including a plurality of vault query services using a business rule configuration to create a real-time
virtual patient object for the individual patient by a singleview framework wherein the singleview framework integrates or
remove data sources without historical data migration;

an adapter for each of the data sources, each adapter translating an interface for one of the data sources to a vault query
service interface; and

a cross-vault query service providing an interface for data communication between an application program and the plurality
of vault query services; and using the real-time virtual patient object when a query is requested to query the data sources,
wherein the cross-vault query service splits the query from the application program into N independent queries, asynchronously
queries each of the medical data sources, combines medical data relating to the individual patient retrieved in response to
the independent queries, wherein the application program interacts with an Enterprise Master Patient Index through a cross-vault
query rules engine, and wherein the Enterprise Master Patient Index identifies multiple patient instances and presents a single
aggregated dataset of the medical data for the individual patient to the application program; and

a user display for displaying the medical data relating to the individual patient retrieved from the data sources in response
to the query.