US Pat. No. 9,310,366

ANTHRAX CARBOHYDRATES, SYNTHESIS AND USES THEREOF

University of Georgia Res...

1. An isolated trisaccharide having the formula

wherein R1=H and R2=

or
wherein R1=Me and R2=

or
wherein R1=Me and R2=


US Pat. No. 9,468,208

DISEASE CONTROL WITH TICK PHOSPHOLIPASE A2

University of Georgia Res...

1. A process of altering the viability of a bacterial organism comprising:
contacting a bacterial organism that is a member of the Spirochaetaceae family or the Treponemataceae family by administering
to a vertabrate host infected with the bacterial organism a salivary protein derived from Amblyomma americanum (A. americanum) wherein said protein has phospholipase A2 (PLA2)-like activity.

US Pat. No. 9,517,474

DEVICES AND METHODS FOR SEPARATING PARTICLES

University of Georgia Res...

1. A kit, comprising a device and a first liquid including a magnetic fluid and two or more types of particles having different
volumes;
wherein the device comprises a first fluid inlet and a second fluid inlet, each being in fluidic communication with a flow
channel, wherein the first fluid inlet includes at least two turns prior to the flow channel, wherein the first fluid inlet,
the second fluid inlet, or both flow the first liquid into the flow channel, wherein the flow channel has a tapered diameter
along a portion of the length of the flow channel;

wherein the device comprises a permanent magnet configured to direct a non-uniform magnetic force onto the magnetic fluid
to control the non-uniform magnetic force exerted on the particles and magnetic buoyancy force experienced by the particles;
and

wherein the device comprises a plurality of outlets, wherein the permanent magnet is configured so that the non-uniform magnetic
force causes the two or more types of particles to be separated and flow into different outlets based on the magnetic buoyancy
force and the volume of the particles, wherein the plurality of outlets includes three or more outlets for separating particles
based upon the different volumes.

US Pat. No. 9,463,227

LISTERIA-BASED ADJUVANTS

ADVAXIS, INC., Princeton...

1. A method of reconstituting an immune response in a subject in an antigen-independent manner, the method comprising the
step of administering a live attenuated recombinant Listeria strain to said subject, wherein said Listeria strain comprises a mutation or a deletion of a genomic internalin C (inlC) gene, and wherein said administration reconstitutes
an immune response in the subject in an antigen-independent manner.
US Pat. No. 9,649,371

RECOMBINANT MUMPS VIRUS VACCINE

UNIVERSITY OF GEORGIA RES...

1. An isolated nucleotide sequence comprising a cDNA sequence encoding the full length RNA genome of a mumps virus, wherein
the cDNA sequence encoding the full length RNA genome of the mumps virus comprises one or more mutations to the V/I/P gene
abrogating expression of a V protein product, wherein the mumps virus is an infectious mumps virus, wherein the one or more
mutations to the V/I/P gene abrogating expression of the V protein comprise replacing the nucleotide sequence GGGGGG with
the nucleotide sequence GAGGAGGG at the editing site in the P/V gene, wherein only a transcript encoding the P protein is
generated from the P/V transcript.
US Pat. No. 9,517,277

IMMUNE-STIMULATING PHOTOACTIVE HYBRID NANOPARTICLES

University of Georgia Res...

1. A multifunctional hybrid nanoparticle, comprising a nanoparticle core comprising a photosensitizer and a polymer, a plurality
of metallic nanoparticles disposed on the surface of the nanoparticle core, and an immunostimulant disposed on the plurality
of metallic nanoparticles, wherein the photosensitizer is zinc phthalocyanine, the nanoparticle core comprises a biodegradable
polymer of poly (D,L-lactic-co-glycolic acid)-b-poly(ethylene glycol), the metallic nanoparticles are gold nanoparticles,
and the immunostimulant disposed on the metallic nanoparticles is a CpG-ODN.
US Pat. No. 9,549,523

WHEAT VARIETY ‘GA 04434-11E44’

University of Georgia Res...

1. A seed of wheat cultivar ‘GA 04434-11E44’, wherein a representative sample of seed of the cultivar has been deposited under
American Type Culture Collection (ATCC) Accession No. PTA-123535.
US Pat. No. 9,587,256

SEQUESTRATION OF CARBON DIOXIDE WITH HYDROGEN TO USEFUL PRODUCTS

University of Georgia Res...

1. A genetically engineered microbe modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate,
wherein the 3-hydroxypropionate is produced at an increased level compared to a control microbe, wherein the microbe is a
hyperthermophile, wherein the microbe is a member of the domain Archaea or a member of the domain Bacteria, and wherein the
microbe comprises an exogenous coding region encoding a polypeptide, wherein the polypeptide has an activity selected from
acetyl/propionyl-CoA carboxylase activity, malonyl/succinyl-CoA reductase activity, and malonate semialdehyde reductase activity.
US Pat. No. 9,226,958

USE OF LISTERIA VACCINE VECTORS TO REVERSE VACCINE UNRESPONSIVENESS IN PARASITICALLY INFECTED INDIVIDUALS

UNIVERSITY OF GEORGIA RES...

1. A method of inducing a Th1 immune response in a subject having a parasitic infection, the method comprising the step of
administering to said subject a therapeutically effective dose of a Listeria vaccine vector, wherein the Listeria vaccine vector expresses and secretes an antigen fused to an additional immunogenic polypeptide or a signal sequence thereof,
wherein said antigen is an infectious disease antigen, and wherein said administering produces a Th1 cell-mediated immune
response in said parasite infected subject.
US Pat. No. 9,127,076

MODIFIED PEPTIDES HAVING TOXIN-ENHANCING EFFECTS

The University of Georgia...

1. A composition for inhibiting lepidopteran insects, wherein said composition comprises a Cry 1 protein and at least one
polypeptide that enhances inhibitory effects of said Cry 1 protein against said lepidopteran insect said polypeptide comprising
a Cry binding domain and wherein said modified fragment resists degradation by a protease and said polypeptide differs from
a wild-type fragment of an insect cadherin ectodomain comprising said binding domain by one or more amino acid deletions or
substitutions that make said polypeptide more resistant to protease degradation than said fragment, wherein said polypeptide
is at least 95% identical with SEQ ID NO:14, and wherein said lepidopteran insects are selected from the group consisting
of Heliothis virescens, Helicoverpa zea, Spodoptera fruqiperda, and Spodoptera exiqua.

US Pat. No. 9,227,943

ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS

University of Georgia Res...

1. A compound of the formula:
wherein:
each R1 is independently selected from the group consisting of hydrogen, halogen, hydroxy, alkoxy, nitrate, nitrite, sulfate, and
a C1-C10 organic group;

each R2 is independently selected from the group consisting of hydrogen, halogen, hydroxy, alkoxy, nitrate, nitrite, sulfate, and
a C1-C10 organic group;

X represents C?O, C?N—OR3, C?N—NR3R4, CHOR3, or CHNHR3;

each R3 and R4 independently represents hydrogen or an organic group; and

R8 represents an organic group.

US Pat. No. 9,732,358

PIV5 AS ONCOLYTIC AGENT

University of Georgia Res...

1. A method of treating a subject with a cancer, the method comprising administering to the subject an effective amount of
a composition comprising an isolated parainfluenza virus 5 (PIV5) virus, wherein the PIV5 virus consists of a virus of a wild
type PIV5 strain or a commercial kennel cough vaccine PIV5 strain and wherein the PIV5 virus does not further comprise a nucleotide
sequence encoding a heterologous polypeptide.

US Pat. No. 9,700,560

2?-FLUORO-6?-METHYLENE CARBOCYCLIC NUCLEOSIDES AND METHODS OF TREATING VIRAL INFECTIONS

UNIVERSITY OF GEORGIA RES...

1. A nucleoside compound according to the structure:

Where B is

Wherein R is H, CH3,


X is H;
Ra is H or a —C1-C4 alkyl group;

R1 and R1a are each independently, H, an acyl group, a C1-C20 alkyl or ether group, an amino acid residue (D or L), a phosphate, diphosphate, triphosphate, phosphodiester or phosphoramidate
group or together R1 and R1a form a carbodiester or phosphodiester group with the oxygen atoms to which they are bonded;

R2 is H, an acyl group, a C1-C20 alkyl or ether group or an amino acid residue (D or L);

Or a pharmaceutically acceptable salt or enantiomer thereof.
US Pat. No. 9,456,561

METHODS AND COMPOSITIONS FOR PRODUCING ALUMINUM TOLERANT ALFALFA

The Samuel Roberts Noble ...

1. A method for increasing the aluminum tolerance of an alfalfa line, said method comprising introgressing at least one chromosomal
locus contributing to aluminum tolerance from a parent alfalfa plant into a selected alfalfa line, wherein said chromosomal
locus maps between loci Mstri9857-18793A97 and AW260-24554 on linkage group 4.
US Pat. No. 9,119,364

METHODS TO IDENTIFY SOYBEAN APHID RESISTANT QUANTITATIVE TRAIT LOCI IN SOYBEAN AND COMPOSITIONS THEREOF

Monsanto Technology LLC, ...

1. A method of producing an aphid resistant population of soybean plants comprising:
A) Genotyping at least one soybean plant from a first population of soybean plants with respect to a soybean genomic nucleic
acid marker of SEQ ID NO: 96, wherein said nucleic acid marker is indicative of an allele conferring aphid resistance in a
soybean plant,

B) Selecting at least one soybean plant from the first population based upon said genotyping for the presence of said allele
conferring aphid resistance in a soybean plant, and

C) Growing from said selected at least one soybean plant a second population of soybean plants,
thereby creating an aphid resistant population of soybean plants comprising the soybean genomic nucleic acid marker of SEQ
ID NO: 96, wherein said nucleic acid marker is indicative of an allele conferring aphid resistance in a soybean plant.

US Pat. No. 9,329,169

VIVO ISOTOPIC LABELING METHOD FOR QUANTITATIVE GLYCOMICS

UNIVERSITY OF GEORGIA RES...

1. A method for comparing the relative abundance of one or more glycans of interest in a modulated biological sample compared
to a control sample comprising:
culturing a first biological sample to be modulated in a first culture medium further comprising 15N-glutamine;

culturing a control sample in a second culture medium identical to said first culture medium further comprising 14N-glutamine;

modulating said first sample during culturing;
processing said first sample and said control sample to extract proteins and/or lipids therefrom;
separating said proteins and/or lipids from said samples after said processing step;
optionally digesting said proteins into a plurality of peptides;
optionally releasing glycans from said proteins, peptides and/or lipids and separating said released glycans from said proteins,
peptides and/or lipids;

subjecting said proteins, said peptides, said lipids and/or said optionally released glycans to mass spectroscopy to develop
a mass spectrum; and

determining the relative abundance of said glycans of interest from each sample based upon said mass spectrum.
US Pat. No. 9,180,138

2?-FLUORONUCLEOSIDES

University of Georgia Res...

1. A method of reducing proliferation of HCV in a host infected with HCV comprising:
administering to the host a ?-D-2?-fluoronucleoside wherein the 2?-fluoro of the ?-D-2?-fluoronucleoside is alpha (?), or
a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier or diluent.

US Pat. No. 9,506,187

TEXTILE DYEING USING NANOCELLULOSIC FIBERS

University of Georgia Res...

1. A method, comprising:
preparing, from at least a plurality of wood pulp fibers, a dyed nanocellulose dispersion comprising a plurality of nanosized
cellulose fibrils using a homogenizer, wherein the dyed nanocellulose dispersion comprises a concentration of between 0.5%
and 6%; and

dyeing a textile material using the dyed nanocellulose dispersion, wherein dyeing the textile material using the dyed nanocellulose
dispersion comprises pad dyeing, rotary screen printing, or package dyeing the textile material.

US Pat. No. 9,566,338

VACCINE DELIVERY METHOD

University of Georgia Res...

1. A composition comprising as one component a peptide hydrogel that is a liquid at room temperature and a gel at physiological
pH, physiological salt concentrations and/or physiological temperatures and as another component one or more vaccine antigens,
wherein the vaccine antigen comprises a schistosomiasis antigen, and wherein the schistosome antigen comprises a SjCTPI polypeptide,
a SjCTPI-Hsp70 polypeptide, a SjC23 polypeptide, and/or a SjC23-Hsp70 polypeptide, or an antigenic fragment thereof.
US Pat. No. 9,422,575

POLYDNAVIRUS DELIVERY CONSTRUCTS

University of Georgia Res...

1. A method of integrating exogenous DNA into the genome of a cell thereby producing a genetically modified cell, comprising
introducing a polydnavirus delivery construct comprising an exogenous nucleic acid to a target cell to form the genetically
modified cell comprising the exogenous nucleic acid, wherein the polydnavirus delivery construct is derived from Microplitis demolitor bracovirus (MdBV).
US Pat. No. 9,353,390

GENETICALLY ENGINEERED MICROBES AND METHODS FOR PRODUCING 4-HYDROXYCOUMARIN

University of Georgia Res...

1. A genetically engineered microbe that comprises a metabolic pathway for the production of 4-hydroxycoumarin from a chorismate
intermediate, wherein the metabolic pathway comprises a salicylate:CoA ligase and an enzyme catalyzing the condensation of
a salicoyl-CoA and a malonyl-CoA to form 4-hydroxycoumarin.
US Pat. No. 9,109,235

METHODS AND COMPOSITIONS FOR DEGRADING PECTIN

University of Georgia Res...

1. A method for degrading pectin comprising:
contacting a composition comprising pectin with a composition comprising an enriched polypeptide, wherein the enriched polypeptide
has pectinase activity under conditions suitable for the degradation of the pectin, wherein the polypeptide comprises an amino
acid sequence, wherein the amino acid sequence and the amino acid sequence of SEQ ID NO:4 have at least 80% identity, and
wherein the pectin is degraded.

US Pat. No. 9,085,789

PAENIBACILLUS SPP. AND METHODS FOR FERMENTATION OF LIGNOCELLULOSIC MATERIALS

University of Georgia Res...

1. A method for producing ethanol comprising:
fermenting a composition comprising a pretreated lignocellulosic material, wherein the fermenting comprises contacting the
composition with an ethanologenic microbe and a Paenibacillus spp., wherein the Paenibacillis spp. produces an enzyme having saccharifying activity when incubated on a medium comprising inorganic salts and a carbon source
selected from glucose, mannose, xylose, arabinose, cellulose, pectin, starch, xylan, carboxymethylcellulose, or a combination
thereof.

US Pat. No. 9,392,764

SOYBEAN VARIETY ‘G12PR-63R2’

University of Georgia Res...

1. A seed of soybean variety ‘G12PR-63R2’, wherein a representative sample of seed of said variety has been deposited under
American Type Culture Collection (ATCC) Accession No. PTA-122508.
US Pat. No. 9,215,869

NON-CADHERIN POLYPEPTIDE POTENTITATORS OF CRY PROTEINS

UNIVERSITY OF GEORGIA RES...

1. A method of inhibiting mosquitos, said method comprising providing to said mosquito for ingestion, a mixture comprising
Bacillus Cry11Ba protein and a polypeptide that is residues 591-843 of SEQ ID NO:2, wherein said polypeptide binds said Cry11Ba protein
and enhances mosquitocidal activity of said Cry11Ba protein.
US Pat. No. 9,211,345

GLYCOPEPTIDE AND USES THEREOF

University of Georgia Res...

1. A glycolipopeptide comprising:
at least one carbohydrate component comprising a self-antigen comprising at least one B-epitope;
at least one peptide component comprising at least one T-epitope; and
at least one lipid component comprising Pam3CysSKn, wherein n=0, 1, 2, 3, 4, or 5.

US Pat. No. 9,452,954

METHOD FOR DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION

University of Georgia Res...

1. A method for decarboxylation of amino acids, the method comprising:
combining, in a pressurized reaction vessel, a mixture of an amino acid, a solvent, and a catalyst, wherein the solvent has
a lower boiling point than cyclohexanol and does not produce a maximum vapor pressure exceeding the vessel limit;

heating the mixture at about 180° C., or more, for about 5 minutes, or more, wherein the amino acid is converted to its imine;
cooling the reaction vessel to a temperature below the boiling point of the solvent;
adding an acid to the reaction mixture in the vessel; and
heating the acid reaction mixture to about 50° C., or more, to hydrolyze the imine to form an amine.
US Pat. No. 9,422,553

PROKARYOTIC RNAI-LIKE SYSTEM AND METHODS OF USE

University of Georgia Res...

1. A method for inactivating a target polynucleotide in a cell comprising:
introducing into a cell a psiRNA comprising at least 23 nucleotides, wherein the psiRNA comprises a psiRNA-tag and a guide
sequence, wherein the psiRNA-tag is the first 5 to 10 nucleotides of the psiRNA and comprises a nucleotide sequence chosen
from nucleotides of a repeat from a CRISPR locus that are immediately upstream of a spacer present in a microbe comprising
the CRISPR locus, wherein the guide sequence is located immediately downstream of the psiRNA-tag and comprises the remaining
nucleotides of the psiRNA, and wherein the guide sequence is complementary to, and hybridizes to, a target polynucleotide
which is cleaved.

US Pat. No. 9,309,276

SYNTHETIC LIPID A DERIVATIVE

University of Georgia Res...

1. A compound having formula I:

wherein:
R1 is an anomeric protecting group;

R2 is azido;

R3 is H or allyloxycarbonate (Alloc);

R4 is a hydroxyl protecting group;

R5 is —NHR11, wherein R11 is fluorenylmethoxycarbamate (Fmoc) or 2,2,2-trichloroethoxycarbonyl (Troc);

R6 is H, allyloxycarbonate (Alloc) or levulinate (Lev); provided that when R6 is H, R3 is allyloxycarbonate (Alloc); and

R7 and R8 are each independently H, a phosphate, a substituted phosphate, a hydroxyl protecting group, or together form a ring.

US Pat. No. 9,315,628

PERMANENT ATTACHMENT OF AGENTS TO SURFACES CONTAINING C-H FUNCTIONALITY

University of Georgia Res...

1. A compound comprising:
R1-(C?O)—R2-X—W, where R1 and R2 are independently selected from the group consisting of: a substituted or unsubstituted aliphatic
group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heteroaryl group; X is selected from
the group consisting of: O, NR3, a substituted or unsubstituted alkyl group, a S group, a substituted or unsubstituted aryl
group, and a substituted or unsubstituted heteroaryl group; wherein R3 is selected from the group consisting of: a substituted
or unsubstituted aliphatic group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heteroaryl
group; and wherein W is a pigment or a dye, wherein substituted includes substitution of one or more H independently with
a halogen or an aliphatic group.

US Pat. No. 9,202,606

FUNCTIONAL NANOSTRUCTURED “JELLY ROLLS” WITH NANOSHEET COMPONENTS

University of Georgia Res...

1. A functionalized multilayer micron-sized scroll structure comprising:
a first layer, wherein the first layer comprises a nanosheet wherein the nanosheet comprises graphene oxide (GO),
a second layer, wherein the second layer comprises titanium (Ti), and
a third layer, wherein the third layer comprises platinum (Pt),
wherein the first layer and the second layer roll spontaneously to form the multilayer micron-sized scroll structure, wherein
the scroll structure is open at both ends and hollow in the center, and wherein the Pt layer comprises the innermost layer
located within the interior of the scroll structure, and the GO layer comprises the outermost layer of the scroll structure.

US Pat. No. 9,416,357

METHOD FOR ISOLATING TOTAL RNA FROM CELLS

University of Georgia Res...

1. A method for isolating cellular ribonucleic acid (RNA), comprising:
(a) suspending cells in an extraction solution comprising formamide in an amount of at least 40% by volume of the extraction
solution;

(b) incubating the cells and formamide mixture of step (a); and
(c) pelleting cell debris, DNA, and protein to form an RNA-containing supernatant.

US Pat. No. 9,346,752

PERMANENT ATTACHMENT OF PIGMENTS AND DYES TO SURFACES CONTAINING CALKYL-OH FUNCTIONALITY

University of Georgia Res...

1. A compound comprising a formula:

wherein Q is selected from the group consisting of: a linear, branched, or cyclic, a substituted or unsubstituted, aliphatic
group, a substituted or unsubstituted aryl group, and R7 is


US Pat. No. 9,309,542

RECOMBINANT CALDICELLULOSIRUPTOR BESCII AND METHODS OF USE

University of Georgia Res...

1. A recombinant Caldicellulosiruptor microbe genetically modified to produce a greater amount of ethanol than a comparable wild type control, wherein the Caldicellulosiruptor microbe:
comprises a knock-out of the coding region of a lactate dehydrogenase and produces lactate in an amount less than a comparable
wild type control;

comprises at least one heterologous polynucleotide that encodes an enzyme in a metabolic pathway that converts acetyl-CoA
to ethanol, wherein the enzyme is an acetaldehyde dehydrogenase that can convert acetyl-CoA to acetaldehyde, an aldehyde dehydrogenase
that can convert acetyl-CoA to acetaldehyde, or a combination thereof; and wherein the Caldicellulosiruptor microbe is C. bescii, C. kristjansonii, C. obsidiansis, C. hydrothermalis, C. kronotskvensis, C. lactoaceticus, or C. saccharolvticus.
US Pat. No. 9,365,626

SIMUKUNIN

University of Georgia Res...

1. A method of inhibiting Factor Xa and inhibiting elastase and/or cathepsin G in a subject, the method comprising administering
to the subject a composition comprising a polypeptide comprising a Kunitz domain and one or more pharmaceutically acceptable
carriers,
wherein the polypeptide comprising a Kunitz domain consists of an isolated simukunin polypeptide comprising an amino acid
sequence at least 95% identical to SEQ ID NO:3 or a fragment thereof,

wherein a fragment thereof comprises a Kunitz domain comprising disulfide bonds between cysteine residues C5 to C55, C14 to
C38, and C30 to C51 of SEQ ID NO:3 and the reaction site loop (RSL) amino acid residues 12 to 17 of SEQ ID NO:3.

US Pat. No. 9,121,044

BIOSYNTHESIS OF CAFFEIC ACID AND CAFFEIC ACID DERIVATIVES BY RECOMBINANT MICROORGANISMS

UNIVERSITY OF GEORGIA RES...

1. A method for producing caffeic acid comprising:
culturing a genetically engineered cell comprising p-coumarate 3-hydroxylase (C3H) enzyme activity, wherein said cell has
been metabolically engineered to express or overexpress a tyrosine ammonia lyase (TAL) and to overexpress a 4-hydoxyphenylacetate
3-hydroxylase (4HPA3H) enzyme or enzyme complex, under conditions effective to produce caffeic acid; and

isolating the caffeic acid from the cell or the culture medium.

US Pat. No. 9,629,339

SYSTEMS AND METHODS FOR REARING INSECT LARVAE

The University of Georgia...

1. A system for rearing larvae, the system comprising:
a plurality of culture trays arranged in at least one stack of trays, each stack comprising multiple levels of trays, each
tray comprising an open-topped basin adapted to receive larvae and larval food;

a feed delivery system adapted to automatically deliver larval feed to individually selected culture trays, the feed delivery
system comprising multiple feed lines, one feed line provided above each level of culture trays of the at least one stack;
and

a water delivery system adapted to automatically deliver water to the culture trays.
US Pat. No. 9,315,468

METHODS INCLUDING LATENT 1,3-DIPOLE-FUNCTIONAL COMPOUNDS AND MATERIALS PREPARED THEREBY

University of Georgia Res...

1. A method of preparing a heterocyclic compound, the method comprising:
providing at least one latent 1,3-dipole-functional compound comprising i) an oxime or ii) an imidoyl chloride;
converting the at least one latent 1,3-dipole-functional compound into at least one active 1,3-dipole functional compound
in the presence of at least one cyclic alkyne, wherein the at least one active 1,3-dipole functional compound comprises a
nitrile oxide;

contacting the at least one active 1,3-dipole functional compound with the at least one cyclic alkyne; and
allowing the at least one active 1,3-dipole-functional compound and the at least one cyclic alkyne to react under conditions
effective for a cycloaddition reaction to form the heterocyclic compound.

US Pat. No. 9,175,260

EARLY MESODERM CELLS, A STABLE POPULATION OF MESENDODERM CELLS THAT HAS UTILITY FOR GENERATION OF ENDODERM AND MESODERM LINEAGES AND MULTIPOTENT MIGRATORY CELLS (MMC)

TheUniversity of Georgia ...

1. A method of differentiating primate Pluripotent Stem Cells (pPSCs) into Isl1+ mesoderm cells comprising (a) providing pPSCs;
(b) contacting the pPSCs with an effective amount of at least one GSK inhibitor selected from the group consisting of a GSK3
inhibitor and a Wnt protein in a cell differentiation medium for a period sufficient to produce mesendoderm cells; and (c)
subsequently contacting the cells obtained from step (b) with an effective amount of a bone morphogenic protein (BMP) and
optionally, a GSK inhibitor selected from the group consisting of a GSK3 inhibitor and a Wnt protein for a period sufficient
to produce said mesoderm cells; and (d) optionally, isolating said mesoderm cells.

US Pat. No. 9,249,440

HYDROGENASE POLYPEPTIDE AND METHODS OF USE

University of Georgia Res...

1. A genetically modified microbe comprising four exogenous polynucleotides, wherein the exogenous polynucleotides each encode
a subunit, wherein a first subunit comprises an amino acid sequence, and the amino acid sequence of the first subunit and
the amino acid sequence of SEQ ID NO:6 have at least 80% identity, wherein a second subunit comprises an amino acid sequence,
and the amino acid sequence of the second subunit and the amino acid sequence of SEQ ID NO:8 have at least 80% identity, wherein
a third subunit comprises an amino acid sequence, and the amino acid sequence of the third subunit and the amino acid sequence
of SEQ ID NO:2 have at least 80% identity, wherein a fourth subunit comprises an amino acid sequence, and the amino acid sequence
of the fourth subunit and the amino acid sequence of SEQ ID NO:4 have at least 80% identity, and wherein the four subunits
form a tetrameric polypeptide having hydrogenase activity, wherein the four subunits are expressed during growth in anaerobic
conditions.
US Pat. No. 9,446,144

GLYCOPEPTIDE AND USES THEREOF

University of Georgia Res...

1. A glycolipopeptide comprising:
at least one carbohydrate component comprising a MUC-1 glycopeptide comprising at least one B-epitope;
at least one peptide component comprising a microbial peptide comprising at least one T-epitope; and
at least one lipid component comprising Pam3CysSKn, wherein n=0, 1, 2, 3, 4, or 5.

US Pat. No. 9,426,955

SOYBEAN VARIETY ‘G06-3182RR’

University of Georgia Res...

1. A seed of soybean variety ‘G06-3182RR’, wherein a representative sample of seed of the variety has been deposited under
American Type Culture Collection (ATCC) Accession No. PTA-121835.

US Pat. No. 9,090,542

METHODS FOR LABELING A SUBSTRATE USING A HETERO-DIELS-ALDER REACTION

University of Georgia Res...

1. A method for selectively labeling a substrate, the method comprising:
providing a precursor compound having one of the formulas:

irradiating the precursor compound at a wavelength of 300 to 350 nm under conditions effective to form an o-naphthoquinone
methide having one of the formulas:

and
contacting the o-naphthoquinone methide with a polarized olefin attached to a surface of a substrate and having the formula:
under conditions effective to form a hetero-Diels-Alder adduct,wherein:
each R1 is independently H, halogen, or an organic group, with the proviso that at least one R1 comprises a detectable label;

each R2 is independently H or an organic group;

each R3 is independently H, halogen, or an organic group;

X is O or NR4;

Y is OR5 or NR53+(Z1/q)? wherein Z is an anion having a negative charge of q;

each R5 is independently H or an organic group;

optionally, two or more R1 groups may be combined to form one or more rings;

optionally, two or more R2 groups may be combined to form one or more rings;

optionally, two or more R3 and/or R4 groups may be combined to form one or more rings;

optionally, two or more R5 groups may be combined to form one or more rings; and

with the proviso that at least one R2, R3, or R4 comprises a linker group attached to the surface of the substrate.

US Pat. No. 9,714,481

PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF MAKING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF USING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, AND METHODS OF MAKING ARTICLES CONTAINING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS

THE UNIVERSITY OF GEORGIA...

1. A material having one of the following structures:

wherein Q is a photo cross-linkable moiety, X is selected from one of C, B, S, Al, Si, P, or Sn, wherein one or more additional
moieties, H or an alkyl group are attached to X as needed to satisfy the normal valence of the atom represented by X, R is
selected from: a substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl,
substituted or unsubstituted cycloalkenyl, substituted or unsubstituted biaryl, substituted or unsubstituted fused aryl, substituted
or unsubstituted alkenyl, and substituted or unsubstituted alkynyl, or a combination of one or more of these, and semicircle
P is selected from a polymer or a compound.

US Pat. No. 10,125,116

COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS

Brandeis University, Wal...

1. A compound, or a pharmaceutically acceptable salt thereof, represented by Formula XIII:
wherein, independently for each occurrence,
X is O;
m is 1;
one occurrence of R2 is hydrogen, and the other occurrence of R2 is alkyl;

p is 0, 1, 2, or 3;
q is 0, 1, 2, 3, or 4; and
R5 is halo, azido, alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, heterocycloalkyl, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, heteroaralkyl, hydroxy, alkoxy, haloalkyloxy, aryloxy, heteroaryloxy, amino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, acyl, carboxyl, alkoxycarbonyl, carboxylic acid, acyloxy, alkylthio, sulfonate, sulfonyl, sulfonamido, formyl, cyano, oxime, or isocyano;
wherein any of the aforementioned alkyl, aryl, or heteroaryl may be substituted with one or more groups independently selected from the group consisting of halo, azido, alkyl, haloalkyl, aralkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, heteroaralkyl, hydroxy, alkoxy, aryloxy, heteroaryloxy, amino, nitro, sulfhydryl, imino, amido, phosphonate, phosphinate, acyl, carboxyl, alkoxycarbonyl, acyloxy, silyl, alkylthio, sulfonate, sulfonyl, sulfonamido, formyl, cyano, and isocyano.

US Pat. No. 9,505,807

PARAINFLUENZA VIRUS 5 BASED VACCINES

University of Georgia Res...

1. A viral expression vector comprising a parainfluenza virus 5 (PIV5) genome comprising a heterologous nucleotide sequence
expressing a heterologous polypeptide, wherein the heterologous nucleotide sequence is inserted between the small hydrophobic
protein (SH) gene and the hemagglutinin-neuraminidase (HN) gene of the PIV5 genome.

US Pat. No. 9,439,421

PERMANENT ATTACHMENT OF AMMONIUM AND GUANIDINE-BASED ANTIMICROBIALS TO SURFACES CONTAINING -OH FUNCTIONALITY

UNIVERSITY OF GEORGIA RES...

1. A compound, comprising an antimicrobial moiety having a structure:
wherein Q is X; wherein R7 is selected from the group consisting of:
wherein X is an antimicrobial agent (AM).

US Pat. No. 9,175,235

TORREFACTION REDUCTION OF COKE FORMATION ON CATALYSTS USED IN ESTERIFICATION AND CRACKING OF BIOFUELS FROM PYROLYSED LIGNOCELLULOSIC FEEDSTOCKS

UNIVERSITY OF GEORGIA RES...

1. A method for reducing coke deposition on a catalyst used in cracking of a pyrolysis oil vapor, the method comprising:
(a) subjecting a biomass to torrefaction;
(b) pyrolyzing the torrefaction-treated biomass, thereby generating a heated pyrolysis oil vapor;
(c) catalytically esterifying the heated pyrolysis oil vapor or components thereof, thereby providing a heated pyrolysis oil
vapor having a reduced acid and aldehyde content compared to a heated pyrolysis oil vapor not catalytically esterified; and

(d) cracking the catalytically esterified heated pyrolysis oil vapor, thereby generating a bio-oil, wherein said cracking
step comprises contacting the heated pyrolysis oil vapor with a second catalyst, and wherein said catalyst accumulates a reduced
coke deposition compared to when the heated pyrolysis oil vapor is generated from a biomass not treated with torrefaction.

US Pat. No. 9,190,185

BULK PURIFICATION AND DEPOSITION METHODS FOR SELECTIVE ENRICHMENT IN HIGH ASPECT RATIO SINGLE-WALLED CARBON NANOTUBES

UNIVERSITY OF GEORGIA RES...

1. A method of purifying and depositing single-walled carbon nanotube (SWNT) networks comprising:
preparing a substrate;
preparing a suspension of SWNTs; and
depositing the SWNT suspension onto the substrate, wherein the deposition method provides control over a density and an alignment
of SWNTs and prevents the SWNTs from forming bundles during deposition, wherein the deposition comprises laminar flow deposition
(LFD),

wetting the substrate with the SWNT suspension on a sample surface;
drying the sample in a stream of gas;
rinsing the sample with water; and
drying the sample in a stream of gas.
US Pat. No. 9,861,652

2? FLUORONUCLEOSIDES

Emory University, Atlant...

1. A method of reducing HCV polymerase activity in a host infected with HCV comprising administering to the host a ?-D-2?-fluoronucleoside
wherein the 2?-fluoro of the ?-D-2?-fluoronucleoside is alpha (?), or a pharmaceutically acceptable salt or prodrug thereof,
optionally in a pharmaceutically acceptable carrier or diluent.

US Pat. No. 9,216,960

SPIRO[2.4]HEPTANES FOR TREATMENT OF FLAVIVIRIDAE INFECTIONS

University of Georgia Res...

1. A method for the treatment of a condition secondary to a hepatitis C infection, selected from the group consisting of weakness,
loss of appetite, weight loss, breast enlargement, rash, difficulty with clotting of blood, spider-like blood vessels on the
skin, confusion, encephalopathy, ascites, esophageal varices, portal hypertension, kidney failure, enlarged spleen, decrease
in blood cells, anemia, thrombocytopenia, jaundice, and hepatocellular cancer, in a host infected with hepatitis C infection,
comprising administering to the host an effective amount of a spiro[2.4]heptane of the following structure:

wherein:
R1 is a natural or non-natural heteroaryl or heterocyclic moiety;

R2 is methyl or F;

R3 is methyl, F, Cl, N3, or OR7;

R4 is OR7, H, methyl, F, Cl, or N3;

R5 is H, phosphate, a stabilized phosphate prodrug, phosphoramidate, acyl, alkyl, sulfonate ester, a lipid, a phospholipid, an
amino acid, a carbohydrate, a peptide, a cholesterol, or other pharmaceutically acceptable leaving group which when administered
in vivo is capable of providing a compound wherein R5 is H or mono, di, or tri-phosphate; and,

R7 is H, acyl, phosphate, sulfate, amino acid, peptide, or an oxygen-protecting group;

or its pharmaceutically acceptable salt;
optionally in a pharmaceutically acceptable carrier.
US Pat. No. 9,157,584

WHITE PHOSPHORS, METHODS OF MAKING WHITE PHOSPHORS, WHITE LIGHT EMITTING LEDS, METHODS OF MAKING WHITE LIGHT EMITTING LEDS, AND LIGHT BULB STRUCTURES

University of Georgia Res...

1. A structure comprising:
a light source and a phosphor composition disposed on the light source, wherein the light source emits radiation in a range
that the phosphor composition absorbs the radiation, and the phosphor composition emits radiation at a wavelength different
than the light source, wherein the phosphor composition includes:

a first phosphor compound (P1) that emits radiation in a specific color of the visible spectrum, and
a second phosphor compound (P2) that emits radiation in a color of the visible spectrum that is complementary to the color
emitted by P1, wherein the combined emissions of P1 and P2 is substantially white light,

wherein both P1 and P2 have a characteristic that they each are excited by incident radiation in the same range of wavelengths,
wherein a ratio of P1:P2 is determined from ?P1/?P2=mP2/mP1, wherein ?P1 denotes an efficiency of conversion of incident radiation into emitted radiation of a certain color b the precursor phosphor
P1, ?P2 denotes an efficiency of conversion of incident radiation into emitted radiation of a certain color b the precursor phosphor
P2, and mP1 and mP2 denote, respectively, the mass of P1 and P2 in the white phosphor.

US Pat. No. 9,334,273

EFFICIENT AND STEREOSELECTIVE SYNTHESIS OF 2?-FLUORO-6?-METHYLENE-CARBOCYCLIC ADENOSINE (FMCA)

UNIVERSITY OF GEORGIA RES...

1. A process for synthesizing the compound of formula 1:

comprising the steps of:
(a) diazotization of the amine of formula 8:

followed by an elimination reaction to produce the alkene of formula 9:

(b) removing the benzoyl protecting groups on the 2? and 3? hydroxyl positions of compound 9 and protecting the 3? and 5?
hydroxyl groups with a 1,1,3,3-tetraisopropyldisiloxane protecting group;

(c) stereoselective epoxidation of the silyl protected compound obtained from step (b) followed by fluorination to yield the
cis-fluoro-?-epoxide of formula 13:


(d) selective opening of the cis-fluoro-?-epoxide of formula 13 and introduction of a methylene group to yield D-2?-fluoro-6?-methylene
cyclopentenol of formula 15:


(e) coupling D-2?-fluoro-6?-methylene cyclopentenol of formula 15 with protected adenine using diisopropyl azodicarboxylate
(DIAD) and triphenylphosphine (TPP) in THF to produce a compound of formula 16, where P represents amine protecting group(s):


and
(f) removing P and the 1,1,3,3-tetraisopropyldisiloxane protecting group of the compound of formula 16 to yield the compound
of formula 1;

wherein the process can be done in one pot or in steps.
US Pat. No. 9,404,098

METHOD FOR CLEAVING A TARGET RNA USING A CAS6 POLYPEPTIDE

University of Georgia Res...

1. A method for cleaving a target RNA polynucleotide sequence comprising:
incubating an isolated target RNA polynucleotide with an isolated wild-type Cas6 (CRISPR-associated 6) polypeptide under conditions
suitable for cleavage of the target RNA polynucleotide to thereby cleave the target RNA polynucleotide,

wherein the target RNA polynucleotide comprises a wild-type CRISPR (Clustered regularly interspaced short palindromic repeats)
locus repeat present in a wild-type prokaryotic genome, and wherein the repeat comprises a recognition domain and a cleavage
site for the wild-type Cas6 polypeptide;

wherein the wild-type Cas6 polypeptide is encoded by said wild-type prokaryotic genome and has Cas6 endoribonuclease activity,
wherein the wild-type Cas6 polypeptide comprises a catalytic triad of tyrosine, histidine, and lysine, at residues corresponding
to Tyr31, His46, and Lys52, respectively, of SEQ ID NO: 2, and comprises a GhGxxxxxGhG (SEQ ID NO: 190) motif wherein h is
a hydrophobic amino acid, and wherein x is any amino acid; and

wherein the wild-type Cas6 polypeptide cleaves the target RNA polynucleotide at the cleavage site of the CRISPR locus repeat,
and wherein the cleavage site is located 5 to 20 nucleotides downstream of the recognition domain for the wild-type Cas6 polypeptide.

US Pat. No. 9,944,854

METHODS AND COMPOSITIONS TO REDUCE SOIL WATER REPELLENCY

University of Georgia Res...

1. A method of reducing soil water repellency (SWR) comprising:applying to an area of groundcover selected from turfgrass soils, farmlands, and agricultural grasslands, the groundcover having SWR associated with localized dry spot (LDS), basidiomycete induced fairy ring, or both and having a water droplet penetration time (WDPT) greater than 60 seconds, an effective amount of a composition comprising least one isolated enzyme capable of degrading or altering organic matter associated with SWR, wherein the isolated enzyme composition is effective to reduce the SWR of the area of groundcover, measured as WDPT, by a measureable amount after treatment with the enzyme composition, and wherein the enzyme is selected from the group of enzymes consisting of: laccase, pectinase, chitinase, cellulase, and a combination of two or more of these enzymes.
US Pat. No. 9,212,346

SUBSTRATE-SELECTIVE CO-FERMENTATION PROCESS

University of Georgia Res...

1. A method for producing a biochemical comprising:
contacting an organic material comprising a mixture of sugars, with a plurality of sugar-selective cells comprising at least
first and second sugar-selective Escherichia coli cells, wherein the first sugar-selective cell selectively metabolizes a first sugar that cannot be metabolized by the second
sugar-selective cell, and the second sugar-selective cell selectively metabolizes a second sugar that cannot be metabolized
by the first sugar-selective cell, wherein the first and second sugars are independently selected from the group consisting
of glucose, xylose, arabinose, and galactose, and wherein at least one of the sugar-selective cells can metabolize only one
sugar independently selected form the group consisting of glucose, xylose, arabinose, and galactose, to yield a co-culture
of sugar-selective cells, under conditions to allow the plurality of sugar-selective cells to produce the biochemical.

US Pat. No. 9,943,590

USE OF LISTERIA VACCINE VECTORS TO REVERSE VACCINE UNRESPONSIVENESS IN PARASITICALLY INFECTED INDIVIDUALS

The Trustees of the Unive...

1. A method of treating an infectious disease in a subject having a Th2 phenotypic profile, the method comprising the step of administering to said subject a therapeutically effective dose of a Listeria vaccine vector, wherein said Listeria vaccine vector expresses and secretes an antigen fused to an additional immunogenic polypeptide or a signal sequence thereof, wherein said antigen is an infectious disease antigen, wherein said Th2 phenotypic profile is parasite-induced, and wherein said administering produces a Th1 cell-mediated immune response in said subject.
US Pat. No. 9,079,977

ANTI-TRYPANOSOMAL PEPTIDES AND USES THEREOF

University of Georgia Res...

1. A composition formulated for the delivery of a hydrophobic drug, the composition comprising an isolated trypanocidal peptide,
wherein the isolated trypanocidal peptide consists of 17 to 25 amino acid residues and comprises a positively charged amino
acid at position minus five relative to the C-terminus of the trypanocidal peptide, and

wherein the trypanocidal peptide comprises at least seventeen consecutive amino acid residues of SEQ ID NO: 1 or a derivative
of SEQ ID NO: 1,

wherein a derivative of SEQ ID NO: 1 has a tryptophan substitution at position 1, 8, and/or 18, a deletion of a single leucine
from the C-terminal leucine triplicate, one hydrophobic amino acid residue of SEQ ID NO: 1 exchanged for another hydrophobic
amino acid, or one positively charged amino acid residue of SEQ ID NO: 1 exchanged for another positively charged amino acid
and

wherein the isolated trypanocidal peptide induces rigidification of the plasma membrane of a bloodstream form of a kinetoplastid
protozoan of the genus Trypanosoma.
US Pat. No. 10,064,898

LISTERIA-BASED ADJUVANTS

ADVAXIS, INC., Princeton...

1. A method of reconstituting an immune response in a subject in an antigen-independent manner, the method comprising administering a live attenuated recombinant Listeria strain to said subject, wherein said Listeria strain comprises a mutation or a deletion of a genomic internalin C (inlC) gene and ActA gene, and wherein said administration reconstitutes said immune response in the subject in an antigen-independent manner.
US Pat. No. 9,790,474

ATTENUATION OF INFECTIOUS BRONCHITIS VIRUS VARIANT GA-13

University of Georgia Res...

1. An attenuated infectious bronchitis virus (IBV) GA13 isolate, wherein the attenuated IBV GA13 isolate comprises GA13 103505
Kd E86 deposited under ATCC Accession Number PTA-124038.

US Pat. No. 9,605,014

GLYCOMIMETICS TO INHIBIT PATHOGEN-HOST INTERACTIONS

University of Georgia Res...

1. A glycomimetic compound having the formula of Type III
and pharmaceutically acceptable salts thereof, wherein
P is independently selected from the group consisting of a halogen, OH, CF3, H, C1-C5 aliphatic ether, C1-C5 aliphatic thioether, NH2, C1-C5 aliphatic amine, C1-C6 aryl amine, C5-C10 aryl ether, C1-C20 aliphatic ester, C6-C20 aryl ester, OCH3, OBenzyl, and OCyclohexyl;

Q is independently selected from the group consisting of a halogen, OH, CF3, H, C1-C5 aliphatic ether, C1-C5 aliphatic thioether, NH2, C1-C5 aliphatic amine, C1-C6 aryl amine, C5-C10 aryl ether, C1-C20 aliphatic ester, and C6-C20 aryl ester;

R is independently selected from H, C1-C5 aliphatic ester, Ac (CH3C?O), C(O)CF3, triazole, and azide;

S is independently selected from the group consisting of an axial or equatorial halogen, OH, H, C1-C5 aliphatic ether, C1-C5 aliphatic thioether, NH2, C1-C5 aliphatic amine, C1-C6 aryl amine, C5-C10 aryl ether, C1-C20 aliphatic ester, and C6-C20 aryl ester;

T is independently selected from the group consisting of a halogen, OH, H, C1-C5 aliphatic ether, C1-C5 aliphatic thioether, NH2, C1-C5 aliphatic amine, C1-C5 aryl amine, C5-C10 aryl ether, C1-C20 aliphatic ester, and C6-C20 aryl ester;

U is independently selected from C1-C5 aliphatic, O, NH, S, and C1-C5 aliphatic amine;

V is independently selected from a C1-C5 aliphatic;

W is independently selected from C1-C5 aliphatic, O, NH, S, and C1-C5 aliphatic amine;

X is independently selected from H, OH, halogen C1-C5 aliphatic ester, C1-C5 aliphatic ether, C5-C10 arylether, C1-C20 aliphatic ester, C6-C20 aryl ester, OCH3, OBenzyl, and OCyclohexyl;

Z is independently selected from C1-C5 aliphatic, C1-C20 aryl, C1-C20 aliphatic ether, C1-C10 aliphatic thioether, NH2, C1-C5 aliphatic amine, C1-C5 aryl amine, C1-C20 aliphatic ester, C6-C20 aryl ether, and a monosaccharide.

US Pat. No. 9,706,959

SYSTEMS AND METHODS FOR MEASURING MITOCHONDRIAL CAPACITY

University of Georgia Res...

1. A system for measuring mitochondrial capacity, the system comprising:
a near-infrared spectroscopy device adapted to measure oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin
of a patient during arterial occlusions; and

a computing device in communication with the near-infrared spectroscopy device that comprises a processor and memory for determining
mitochondrial capacity, the memory comprising instructions stored thereon that when executed by the processor perform the
steps of:

receive measurements of the oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measured by the near-infrared
spectroscopy device,

calculating a blood volume correction factor that accounts for a change in blood volume that occurs during the arterial occlusions,
and

apply the correction factor to the oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements to obtain
corrected measurements, and calculating oxygen consumption using the corrected measurements.

US Pat. No. 9,689,939

SPLIT BIRDCAGE COIL, DEVICES, AND METHODS

University of Georgia Res...

1. A device comprising:
a dual-tuned birdcage coil comprising an inner multinuclear coil and a plurality of outer 1H coils, the plurality of outer coils being longitudinally separated along an axis from the inner coil and not directly connected
to the inner coil, the inner coil being inductively coupled to one or more of the outer coils, the inner coil being tunable
independently from one or more of the outer coils.

US Pat. No. 9,725,405

ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS

University of Georgia Res...

1. An alkyne of the formula:

wherein:
each R1 is independently selected from the group consisting of hydrogen, halogen, hydroxy, alkoxy, nitrate, nitrite, sulfate, and
a C1-C10 organic group;

each R2 is independently selected from the group consisting of hydrogen, halogen, hydroxy, alkoxy, nitrate, nitrite, sulfate, and
a C1-C10 organic group;

X represents C?O, C?N—OR3, C?N—NR3R4, CHOR3, or CHNHR3;

R3 represents a covalently bound fluorescent organic dye; and

R4 represents hydrogen or an organic group.

US Pat. No. 9,719,113

MICROBIAL PRODUCTION OF MUCONIC ACID AND SALICYLIC ACID

University of Georgia Res...

1. A genetically engineered microorganism comprising a genetically engineered metabolic pathway for the production of muconic
acid from a salicylic acid intermediate, said pathways comprising:
a plurality of enzymes associated with the biosynthesis of salicylic acid, said plurality of enzymes comprising an isochorismate
synthase (ICS) and an isochorismate pyruvate lyase (IPL); and

a plurality of enzymes associated with the conversion of salicylic acid to muconic acid, said plurality of enzymes comprising
a salicylate 1-monoxygenase (SMO) and a catechol 1,2-dioxygenase (CDO).

US Pat. No. 10,022,451

ENCAPSULATED AGENTS AND METHODS OF MAKING AND USING THEREOF

University of Georgia Res...

1. A composition, comprising:an apoprotein cage comprising a metal binding site, and
a therapeutic agent comprising a metal and a photosensitizer derived from a tetrapyrollic compound,
wherein the therapeutic agent is encapsulated within the apoprotein cage, and
wherein the composition comprises at least 10 wt % of the therapeutic agent.
US Pat. No. 9,968,671

AVIAN REOVIRUS VACCINES

University of Georgia Res...

1. An isolated avian reovirus, wherein the avian reovirus comprises:a sigma C protein comprising an amino acid sequence with at least 99% sequence identity to SEQ ID NO:4 and comprising at least one amino acid difference from SEQ ID NO:4,
wherein the avian reovirus is attenuated relative to an avian reovirus comprising a sigma C protein with an amino acid sequence comprising SEQ ID NO:4 by at least 25 passages in an egg or a host cell line.

US Pat. No. 9,691,998

SINGLE-WALLED CARBON NANOTUBES/QUANTUM DOT HYBRID STRUCTURES AND METHODS OF MAKING AND USE OF THE HYBRID STRUCTURES

UNIVERSITY OF GEORGIA RES...

1. A structure comprising:
a substrate,
a network of single-walled carbon nanotubes (SWCNTs), wherein the SWCNTs are substantially aligned, or, alternatively, wherein
the SWCNTs are oriented in a crossbar formation with the SWCNTs at least partially orthogonally distributed, wherein the orientation
of the SWCNTs is controlled by the direction of a unidirectional stream of nitrogen during successive drying cycles, and

a plurality of quantum dots (QDs) on the network of SWCNT, wherein the quantum dots are in contact with the SWCNTs in the
network providing a SWCNT/QD network.

US Pat. No. 9,603,329

WHEAT CULTIVAR ‘GA 04570-10E46’

University of Georgia Res...

1. A seed of wheat cultivar ‘GA 04570-10E46’, wherein a representative sample of seed of the cultivar has been deposited under
American Type Culture Collection (ATCC) Accession No. PTA-123659.
US Pat. No. 9,560,826

WHEAT VARIETY ‘GA 041293-11E54’

University of Georgia Res...

1. A seed of wheat cultivar ‘GA 041293-11E54’, wherein a representative sample of seed of the cultivar has been deposited
under American Type Culture Collection (ATCC) Accession No. PTA-123536.

US Pat. No. 9,839,213

PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF MAKING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF USING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, AND METHODS OF MAKING ARTICLES CONTAINING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS

THE UNIVERSITY OF GEORGIA...

1. A material comprising a structure selected from:
wherein Q is a photo cross-linkable moiety selected from the group consisting of: an aryl ketone, an aryl azide group, a diazirine
group, and a combination thereof, X? is selected from one of C, O, B, S, Al, Si, P, or Sn, wherein one or moieties are bonded
to X? to satisfy the valence of X?, R is selected from: a substituted or unsubstituted alkyl, substituted or unsubstituted
cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl,
substituted or unsubstituted biaryl, substituted or unsubstituted fused aryl, substituted or unsubstituted alkenyl, and substituted
or unsubstituted alkynyl, or a combination of one or more of these, semicircle P is a particle, and wherein Z is an acrylic
acid group, an ester of an acrylic acid group, an alcohol, a diol, a polyol, or a diacid.
US Pat. No. 9,663,768

PRECURSOR-DIRECTED BIOSYNTHESIS OF 5-HYDROXYTRYPTOPHAN

UNIVERSITY OF GEORGIA RES...

1. A microbial system for the production of 5-hydroxytryptophan (5-HTP) comprising a plurality of genetically engineered cells
comprising:
a first genetically engineered cell comprising (i) at least one shikimate pathway enzyme, (ii) at least one enzyme having
anthranilate synthase activity, and (iii) at least one enzyme having salicylate 5-hydroxylase (S5H) activity, which enzyme
further has activity toward anthranilate (AA); and

a second genetically engineered cell comprising at least one enzyme having tryptophan biosynthesis activity, wherein the enzyme
catalyzes the conversion of anthranilate (AA) to tryptophan and further has activity toward 5-hydroxyanthranilate (5-HAA).

US Pat. No. 9,732,322

COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPS), EPICARDIAL PROGENITOR CELLS (EPCS) AND MULTIPOTENT C56C CELLS (C56CS) AND METHODS OF PRODUCING AND USING SAME

UNIVERSITY OF GEORGIA RES...

1. A method of producing a population of human epicardial pluripotent cells (EPCs) from human ISL1+ multipotent progenitor
cells (IMPs) comprising providing a population of human IMPs produced from differentiating human pluripotent stem cells; exposing
said population of IMPs in a differentiation media to an effective amount of Wnt3a, BMP4 and retinoic acid to produce a population
of human EPCs; and optionally, isolating said human EPCs.

US Pat. No. 9,879,117

PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF MAKING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF USING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, AND METHODS OF MAKING ARTICLES CONTAINING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS

University of Georgia Res...

1. A structure, comprising:
a surface having a polymer, wherein the polymer comprises a linear or branched polyethylenimine polymer that has been quaternized
with a hydrophobic side chain moiety (R1) and a photo cross-linkable moiety (B), wherein the polymer is covalently attached
to the surface through the photo cross-linkable moiety, and wherein the structure has an antimicrobial characteristic, wherein
the linear or branched polyethylenimine polymer has the following structure:


wherein R1 is a hydrocarbon chain including a C?C group in the chain, wherein R2 is a hydrocarbon carbon chain linking moiety,
saturated or unsaturated, wherein the structure is selected from the group consisting of: a fabric, a textile article, a natural
fiber, a synthetic fiber, a porous membrane, a plastic structure, a oxide structure having a functionalized layer on the surface
of the structure, a metal structure having a functionalized layer on the surface of the structure, a glass structure having
a functionalized layer on the surface of the structure, and a combination thereof.

US Pat. No. 10,023,889

MICROBIAL APPROACH FOR THE PRODUCTION OF 5-HYDROXYTRYPTOPHAN

University of Georgia Res...

1. A genetically engineered bacterial cell comprising a modified bacterial phenylalanine-4-hydroxylase (P4H) that catalyzes the 5-hydroxylation of tryptophan in the presence of a tetrahydromonapterin (MH4) cofactor, wherein the modified P4H comprises a P4H from Xanthomonas campestris having an amino acid mutation at any one, any two, or all three of amino acid positions 98, 179, and 231 of SEQ ID NO: 1, or a modified P4H from Pseudomonas or Ralstonia, selected from the group consisting of: a P4H from P. aeruginosa comprising an amino acid mutation at any one, any two, or all three of amino acid positions 84, 162, and 213 of SEQ ID NO: 2, a P4H from P. putida having an amino acid mutation at any one, any two, or all three of amino acid positions 84, 162, and 213 of SEQ ID NO: 3, a P4H from P. fluorescence comprising an amino acid mutation at any one, any two, or all three of amino acid positions 84, 162, and 213 of SEQ ID NO: 4, or a P4H from R. eutropha H16 comprising an amino acid mutation at any one, any two, or all three of amino acid positions 113, 192, and 244 of SEQ ID NO: 5.

US Pat. No. 10,036,047

METHODS FOR HYDROXYLATING PHENYLPROPANOIDS

UNIVERSITY OF GEORGIA RES...

1. A method for producing an ortho-hydroxylated phenylpropanoid comprising:culturing a microbe comprising HpaBC activity in the presence of a phenylpropanoid substrate under conditions suitable to ortho-hydroxylate the phenylpropanoid substrate to result in an ortho-hydroxylated phenylpropanoid,
wherein the microbe comprises coding regions encoding HpaB and HpaC, the HpaB comprising an amino acid sequence having at least 95% sequence identity with the amino acid sequence of SEQ ID NO:1, and the HpaC comprising an amino acid sequence having at least 95% sequence identity with the amino acid sequence of SEQ ID NO:2,
wherein the phenylpropanoid substrate comprises a first six-carbon ring and at least one additional cyclic structure, and wherein the phenylpropanoid substrate comprises a structure having the formula

 wherein R1 is the position at which the phenylpropanoid substrate is ortho-hydroxylated by HpaBC, and
wherein R2 is a divalent organic linking group that comprises the additional cyclic structure and wherein R3 is a hydrogen or a nonring substituent, or
wherein R2 is joined to R3 to form the additional cyclic structure; and
isolating the ortho-hydroxylated phenylpropanoid from the microbe or the culture medium, or the combination thereof.

US Pat. No. 10,005,719

METHOD FOR DIRECTED CATALYTIC FUNCTIONALIZATION OF ALCOHOLS

University of Georgia Res...

1. A method for the ortho-arylation of a benzylic alcohol, comprising the steps of:(a) generating a quinolinyl hemiacetal benzoate scaffold having the formula II;

(b) reacting a benzylic alcohol of formula I
with the quinolinyl hemiacetal benzoate scaffold of formula II in the presence of trifluoroacetic acid to provide a compound of formula III:
(c) reacting the compound of formula III with an arylboronic pinacol ester having the formula IVa:
in the presence of a palladium acetate, rhodium acetate, or ruthenium acetate catalyst; an N-acetylated amino acid metal catalyst ligand selected from the group consisting of Ac-Glycine-OH, Ac-Valine-OH, Ac-Alanine-OH, Ac-Leucine-OH, Ac-Isoleucine-OH, and Ac-tert-butylleucine-OH; a silver salt; and a base selected from the group consisting of: Na2CO3, KHCO3, K2CO3, K3PO4, and Cs2CO3 to provide a compound of formula Va:
(d) reacting the compound formula Va of step (c) with an acid and an alcohol, said alcohol having the formula R13OH to provide an ortho-arylated benzylic alcohol of formula VIa
and a quinolinyl hemiacetal alkoxy scaffold having the formula VII;whereinR1, R2, and R3 are independently selected from the group consisting of: hydrogen, an alkyl, an aryl, R1 and R2 forming an aryl ring, and R2 and R3 forming an aryl ring;
R11 and R12 are independently hydrogen or an alkyl; and
R13 is an alkyl or substituted alkyl;
Ar is an unsubstituted or substituted aryl; and
n is 1 or 2.
US Pat. No. 9,907,822

THERAPEUTIC COMPOSITIONS AND METHODS FOR TREATING INFECTIONS

University of Georgia Res...

1. A composition comprising a transgenic T. cruzi that expresses a heterologous pathogen associated molecular pattern (PAMP) or a damage associated molecular patterns (DAMP).

US Pat. No. 10,004,809

PRECISE DELIVERY OF THERAPEUTIC AGENTS TO CELL MITOCHONDRIA FOR ANTI-CANCER THERAPY

University of Georgia Res...

1. A compound having Formula I the following formula:
where
p is from 1 to 3; and
X3 is a linker
or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,932,297

ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS

UNIVERSITY OF GEORGIA RES...

1. A compound of the formula:wherein:each R1 is independently selected from the group consisting of hydrogen, halogen, hydroxy, alkoxy, nitrate, nitrite, sulfate, and a C1-C10 organic group;
each R2 is independently selected from the group consisting of hydrogen, halogen, hydroxy, alkoxy, nitrate, nitrite, sulfate, and a C1-C10 organic group;
X represents C?O, C?N—OR3, C?N—NR3R4, CHOR3, or CHNHR3;
each R3 and R4 independently represents hydrogen or an organic group; and
R8 represents an organic group.

US Pat. No. 9,938,312

COMPOUNDS AND METHODS FOR CHEMICAL AND CHEMO-ENZYMATIC SYNTHESIS OF COMPLEX GLYCANS

University of Georgia Res...

1. An orthogonally protected branched oligosaccharide having the formula (I):
wherein each of R1, R4, R6 and R8 is independently an orthogonal protecting group or a permanent protecting group, provided that at least two of R1, R4, R6 and R8 are orthogonal protecting groups;
each of R2, R3, R5, R7, and R10 is independently a permanent protecting group;
R9 is an orthogonal protecting group, a permanent protecting group, or a glucosamine moiety;
X is —OR15 or —SR16;
R15 is H, alkyl, cycloalkyl, substituted alkyl or cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl or substituted aryl; a protecting group; an anomeric spacer or linker; a fluorous tag; or a leaving group; and
R16 is H, alkyl, cycloalkyl, substituted alkyl or cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, or substituted aryl.
US Pat. No. 9,901,616

APOPTOSIS-TARGETING NANOPARTICLES

UNIVERSITY OF GEORGIA RES...

1. A nanoparticle comprising:
cholesteryl oleate
a polymer consisting essentially of poly(lactic-co-glycolic acid) (PLGA);
a block copolymer comprising a PLGA block and a polyethylene glycol (PEG) block;
a first compound comprising PEG attached to a phospholipid, and a targeting moiety attached to the PEG or conjugated to a
lipid moiety for interaction with the phospholipid, wherein the targeting moiety is selected from the group consisting of
a zinc 2,2?-dipicolylamine (Zn2+- DPA) coordination complex, a PS-targeting polypeptide comprising an amino acid sequence selected from the group consisting
of LIKKPF (SEQ ID NO:1), PGDLSR (SEQ ID NO:2), and DAHSFS (SEQ ID NO:3), a triphenyl phosophonium (TPP) moiety, a Szeto-Shiller
peptide, and a rhodamine cation;

a second compound comprising a macrophage targeting moiety attached to a phospholipid, wherein the macrophage targeting moiety
is selected from the group consisting of a mannose moiety, a galactose moiety, or lactobionic acid moiety; and

an apoA-I peptide mimetic,
wherein the polymer consisting essentially of PLGA and the PLGA block of the block copolymer form a hydrophobic core of the
nanoparticle,

wherein the PEG block of the block copolymer forms a hydrophilic layer surrounding the core,
wherein the cholesterol oleate is bound to the core,
wherein the apoA-I peptide mimetic is bound to the core,
wherein the targeting moiety extends from the core, and
wherein the macrophage targeting moiety extends from the core.

US Pat. No. 9,816,948

COMPUTERIZED TOMOGRAPHY DETECTION OF MICROBIAL DAMAGE OF PLANT TISSUES

University of Georgia Res...

1. A non-transitory computer-readable medium embodying a program executable in at least one computing device, comprising code
that:
accesses a computed tomography (CT) image of an onion bulb;
processes the image of the CT image to adjust a quality of the CT image;
identifies an outline of the onion bulb in the CT image;
identifies a plurality of interior voids of the onion bulb;
generates a shape description of the onion bulb based at least in part on the plurality of interior voids, the outline of
the onion bulb, or a combination thereof;

generates a plurality of measurements for the interior voids of the onion bulb; and
generates a classification for the onion bulb describing a condition of the onion bulb based at least in part on the plurality
of measurements, the shape description, or a combination thereof, wherein performing image processing further comprises generating
a modified image of the onion bulb comprising only the plurality of interior voids of the onion bulb, wherein the classification
is generated based at least in part on the modified image.

US Pat. No. 9,954,619

PHOTONIC IMPLEMENTATION OF JAMMING AVOIDANCE RESPONSE

UNIVERSITY OF GEORGIA RES...

1. A jamming avoidance response (JAR) system, comprising:a photonic P-unit configured to generate optical pulses that correspond to a raising envelope of a beat signal associated with an interference signal and a reference signal;
a photonic ELL/T-unit configured to generate optical spikes that correspond to positive zero crossing points of the reference signal;
a photonic TS unit configured to provide a phase output that indicates whether the beat signal is leading or lagging the reference signal, the phase output based at least in part upon the optical spikes; and
a logic unit configured to determine an adjustment to a reference frequency based at least in part upon the optical pulses and the phase output.

US Pat. No. 9,873,126

DEVICES AND METHODS FOR SEPARATING PARTICLES

University of Georgia Res...

1. A method for separating particles from a liquid comprising a magnetic fluid and at least two types of particles having
different volumes, the method comprising:
flowing the liquid down a channel having two or more outlets in fluidic communication with the channel;
exposing the magnetic fluid to a non-uniform magnetic force to control the non-uniform magnetic force exerted on the particles
and magnetic buoyancy force experienced by the particles; and

separating the at least two types of particles into different outlets of the two or more outlets based on the magnetic buoyancy
force and the volume of the particles;

wherein the particles are cells.
US Pat. No. 10,053,667

DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TO MULTIPOTENT NEURAL CREST CELLS

University of Georgia Res...

1. A method of producing p75+ Hnk1+ Ap2+ multipotent neural crest-like cells from human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hiPSCs) comprising differentiating said stem cells in a differentiation medium in the absence of feeder cells consisting essentially of an effective amount of a glycogen synthase kinase (GSK) inhibitor in combination with an effective amount of an Activin A inhibitor to produce a population of cells comprising p75+ Hnk1+ Ap2+ multipotent neural crest-like stem cells and PAX6+ neural progenitor cells, wherein said GSK inhibitor is (2?Z,3?E)-6-Bromoindimbin-3?-oxime (BIO) and said Activin A inhibitor is SB 431542 and wherein said PAX6+ neural progenitor cells produced comprise no more than 10% of the total population of p75+ Hnk1+ Ap2+ multipotent neural crest-like cells and PAX6+ neural progenitor cells; and optionally isolating said neural p75+ Hnk1+ Ap2+ multipotent neural crest-like cells from said population of cells.

US Pat. No. 10,010,074

PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF MAKING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, METHODS OF USING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS, AND METHODS OF MAKING ARTICLES CONTAINING PHOTOCHEMICAL CROSS-LINKABLE POLYMERS

UNIVERSITY OF GEORGIA RES...

1. A structure, comprising:a surface having a polymer covalently attached to the surface, wherein the structure has an antimicrobial characteristic; and
wherein the polymer is a linear or branched polyethylenimine polymer that has been quaternized with a hydrophobic side chain moiety (R1) and a photo cross-linkable moiety (B), wherein the polymer is covalently bonded to the surface through the photo cross-linkable moiety, wherein the linear or branched polyethylenimine polymer has the following structure:

wherein R2 is a linking moiety and is a hydrocarbon carbon chain that includes 3 to 20 carbons and includes one or more double or triple bonds, wherein the R2 is substituted or unsubstituted, and wherein “m” and “n” are each independently 1 to 1000; wherein R1 is saturated and includes 1 to 20 carbons and is substituted or unsubstituted.

US Pat. No. 10,099,981

METHODS FOR META-ARYLATION OF AROMATIC ALCOHOLS

University of Georgia Res...

1. A method of meta-arylating an arene alcohol, the method comprising the steps of:(a) replacing a benzoate group of a quinolinyl hemiacetal benzoate with an aromatic alcohol or a substituted aromatic alcohol wherein the aromatic alcohol or a substituted aromatic alcohol has the formula II:
thereby forming form a compound of formula III:
(b) reacting the compound of formula III with an aryl iodide having the formula I:
in the presence of a palladium trifluoroacetate catalyst, silver acetate, trifluoroacetylglycine, and carboxymethyl norbornene to generate a meta-arylated arene-quinolinyl hemiacetal scaffold conjugate; and(c) incubating the meta-arylated arene-quinolinyl hemiacetal scaffold conjugate of step (b) with an alkyl alcohol under acid conditions to generate an alkylated quinolinyl hemiacetal scaffold having the formula V:
and a meta-arylated arene alcohol having the formula VI:wherein:R1, R2, or R3 are independently selected from the group consisting of: H, a halogen, an alkyl, a substituted alkyl, an aryl, a substituted aryl, an amino group, a substituted amino group, an alkoxy group, a heterocyclic group, R1 and R2 are linked to form a cyclic group and R2 and R3 are linked to form a cyclic group; and
R4 is selected from the group consisting of: H, a halogen, an alkyl, an alkoxy, a carboxyalkyl, an alkylbenzoate, a substituted amine, an ether group, a ketone group, an ester group, a carbamate group, a nitro group, and a halogenated alkyl group.
US Pat. No. 9,926,612

GLYCAN-SPECIFIC ANALYTICAL TOOLS

University of Georgia Res...

1. A method for generating a lectenz comprising an inactivated mutated carbohydrate-processing enzyme having enhanced affinity for its substrate compared to a corresponding wild-type carbohydrate-processing enzyme, the method comprising:(a) providing a 3D structure of an enzyme-substrate complex comprising a substrate bound to a catalytically inactive mutant carbohydrate-processing enzyme or a corresponding wild-type carbohydrate-processing enzyme, wherein the catalytically inactive carbohydrate-processing enzyme comprises an amino acid sequence comprising at least one inactivating mutation that eliminates catalytic activity of the enzyme;
(b) performing a computational simulation on the enzyme-substrate complex to predict the per-residue contributions to total interaction energy (?EMM) and/or total binding free energy (?GBinding) for amino acid residues of the enzyme;
(c) analyzing the per-residue energetic contributions to identify at least one amino acid residue as a potential mutation site for enhancing binding affinity of the inactivated enzyme for its substrate as compared to a wild-type enzyme, wherein an amino acid residue is identified as a potential mutation site for enhancing binding activity when
(i) for an amino acid residue located within 5 ? of the substrate in the enzyme-substrate complex, the per-residue contribution of the amino acid residue to at least one of ?EMM or ?GBinding is ??0.7 kcal/mol; and
(ii) for an amino acid residue located more than 5 ? from the substrate in the enzyme-substrate complex, the per-residue contribution of the amino acid residue to at least one of ?EMM or ?GBinding is ?0.0 kcal/mol;
(d) expressing a library of inactivated mutated carbohydrate-processing enzymes, each inactivated mutated enzyme comprising a plurality of amino acid mutations, wherein
each inactivated mutated enzyme comprises at least one inactivating mutation that eliminates catalytic activity of the enzyme; and
each inactivated mutated enzyme further independently comprises at least one potential affinity-enhancing mutation at a site identified in step (c);
(e) assaying the inactivated mutated enzymes of step (d) for their ability to form the enzyme-substrate complex; and
(f) identifying inactivated mutated enzymes from step (e) that exhibit binding affinities to the substrate that are at least 1.2-fold greater than those of the wild-type carbohydrate-processing enzyme.

US Pat. No. 9,930,065

MEASURING, CATEGORIZING, AND/OR MITIGATING MALWARE DISTRIBUTION PATHS

University of Georgia Res...

1. A system for event path traceback comprising:at least one processor; and
a data storage device having computer readable program code embodied therewith;
the at least one processor configured to execute the computer readable program code to perform processing associated with receiving network traffic from a network; and
an attack path traceback and categorization module in communication with the at least one processor, the attack path traceback and categorization module being configured to perform processing associated with identifying an event within the network traffic;
tracing a sequence of network transactions related to the event; and
outputting an annotated malware path including data about the event and the sequence of network transactions related to the event;
wherein performing processing associated with tracing the sequence of network transactions comprises:
reconstructing a sequence of transactions within the network traffic that led to the event based on a download referrer, at least one surrogate referrer indicator, and at least one of a drive-by uniform resource identifier similarity and a download domain recurrence, wherein the at least one surrogate referrer indicator is not the download referrer, and
filtering out unrelated traffic within the network traffic.
US Pat. No. 10,147,505

METHODS OF ASSESSING A RISK OF DEVELOPING NECROTIZING MENINGOENCEPHALITIS

The Translational Genomic...

1. A method for treating a canine subject for necrotizing meningoencephalitis (NME), comprising:extracting genomic DNA from a sample from the canine subject;
assaying the genomic DNA for one or more single nucleotide polymorphisms (SNPs), wherein the one or more SNPs comprises BICF2P608380 corresponding to position 1575622 on SEQ ID NO: 1 and BICF2P178662 corresponding to position 453486 on SEQ ID NO: 1;
detecting a G allele at BICF2P608380 and an A allele at BICF2P178662 in the genomic DNA from the sample; and
administering an effective amount of an immunosuppressive treatment to the canine subject having the G allele at BICF2P608380 and the A allele at BICF2P178662, wherein the canine subject is selected from the group consisting of Pug, Chihuahua, and Maltese.
US Pat. No. 10,138,306

METHACRYLIC ACID PRODUCTION METHOD

University of Georgia Res...

1. A method of producing methacrylic acid comprising reacting a substrate with a palladium nitrate catalyst comprising a hydrotalcite under conditions sufficient to produce methacrylic acid in a single step, wherein the substrate is selected from the group consisting of 2-hydroxyisobutyric acid or salts thereof, itaconic acid or salts thereof, citric acid or salts thereof, citramalic acid or salts thereof, and combinations thereof.

US Pat. No. 10,542,932

SYSTEMS AND METHODS FOR MEASURING MITOCHONDRIAL CAPACITY

University of Georgia Res...

1. A method for measuring mitochondrial capacity, the method comprising:applying an occlusion device to a limb of a patient;
applying a sensor and at least one electrode of a near-infrared spectroscopy (NIRS) device to the limb at a point distal of the occlusion device;
performing one or more arterial occlusions on the patient's limb by constricting blood flow through the patient's arteries with the occlusion device;
measuring with the near-infrared spectroscopy device oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin within the patient's limb during the occlusions;
receiving with a computing device in communication with the near-infrared spectroscopy device measurements of the oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measured by the near-infrared spectroscopy device, the computing device comprising a processor and memory that stores instructions for determining mitochondrial capacity;
calculating with the computing device a blood volume correction factor that accounts for a change in blood volume that occurs during the arterial occlusions; and
applying with the computing device the correction factor to the measured oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements to compute corrected oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements.
US Pat. No. 10,137,188

CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE

University of Georgia Res...

1. An engineered cell line, wherein cells of the engineered cell line comprise decreased endogenous expression of at least one coding region selected from Table I compared to a control cell line, wherein the at least one coding region is selected from ZNF205, CNTD2, SEC61G, ETS1, TAF1L, MCCD1, LY6G6C, BTN2A1, GLRXL, GCGR, or EP300, and wherein the cells comprise an edited genome that results in decreased endogenous expression of the coding region, wherein the edited genome comprises a mutation of the genomic DNA of the engineered cell compared to a control cell line.
US Pat. No. 10,118,898

METHOD FOR DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION

UNIVERSITY OF GEORGIA RES...

1. A method for decarboxylation of amino acids to produce an amine via an imine intermediate, the method comprising:(a) combining, in a pressurized reaction vessel, a mixture of an amino acid, a solvent, and a catalyst, the catalyst comprising a ketone, enone, enal, aldehyde, or combination thereof;
(b) heating the mixture at about 180° C., or more, for about 5 minutes, or more, wherein the amino acid is converted to its imine;
(c) cooling the reaction mixture from step (b) in the reaction vessel to a temperature below the boiling point of the solvent;
(d) adding an acid to the cooled reaction mixture from step (c) in the vessel; and
(e) heating the acid reaction mixture from step (d) to about 50° C., or more, to hydrolyze the imine to form an amine.

US Pat. No. 10,547,280

PHOTONICS BASED TUNABLE MULTIBAND MICROWAVE FILTER

University of Georgia Res...

1. A radio frequency (RF) filter, comprising:a Lyot filter comprising a tunable birefringence loop comprising a length of polarization maintaining fiber (PMF), a circulator and a polarization controller (PC), the PC coupled to a distal end of the PMF through the circulator, where a received optical signal is provided to the PMF through a loop coupling circulator coupled to a proximal end of the PMF, the Lyot filter configured to generate an optical comb based at least in part upon the received optical signal and a polarization rotation angle of the PC; and
a phase modulator (PM) configured to generate a modulated tap signal by modulating the optical comb by a RF input signal.
US Pat. No. 10,421,788

SYNTHESIZING VACCINES, IMMUNOGENS, AND ANTIBODIES

THE GENERAL HOSPITAL CORP...

1. A method of synthesizing an immunogen, the method comprising:providing a plurality of variants of a glycoprotein antigen;
providing an antibody;
determining a binding profile of each of the plurality of variants for the antibody;
identifying a plurality of consensus glycosylation sites for each of the plurality of variants;
determining a glycan occupancy rate for each of the plurality of consensus glycosylation sites;
identifying a subset of the plurality of glycosylation sites that are glycan determinants based on the determined glycan occupancy rates and binding profiles using a probabilistic model with a machine learning algorithm; and
synthesizing an immunogen based on the glycoprotein antigen with an altered affinity for the antibody by modifying at least one of the subset of the plurality of glycosylation sites that are glycan determinants.

US Pat. No. 10,056,659

PHOTOSYNTHETIC ELECTROCHEMICAL CELLS

University of Georgia Res...

1. A photosynthetic electrochemical cell comprising:an anode composite comprising an anode, a matrix of nanostructured materials coupled to the anode, and at least one photosynthetic microorganism coupled to the anode via the matrix of nanostructured material in electrochemical communication with the photosynthetic microorganism, such that the photosynthetic microorganism is coupled to the matrix of nanostructured material and the matrix of nanostructured material is located between the anode and the photosynthetic microorganism, wherein the photosynthetic microorganism is capable of oxidizing water molecules and generating electrons using light induced photo-electrochemical reactions and wherein the anode composite is configured such that at least some electrons generated by the photosynthetic organism are conducted to the anode via direct electron transfer; and
a cathode composite comprising a cathode and at least one enzyme or metallic catalyst capable of reducing O2.
US Pat. No. 10,563,178

PIV5-BASED AMPLIFYING VIRUS-LIKE PARTICLES

University of Georgia Res...

1. An amplifying virus-like particle consisting of:(i) an isolated polynucleotide sequence consisting of genes encoding a PIV5 nucleocapsid protein (NP), a PIV5 phosphoprotein (V/P) and a PIV5 large RNA polymerase (L), and
(ii) an expressible heterologous non-PIV5 nucleotide sequence between the V/P and L genes.
US Pat. No. 10,227,617

SEQUESTRATION OF CARBON DIOXIDE WITH HYDROGEN TO USEFUL PRODUCTS

UNIVERSITY OF GEORGIA RES...

1. A genetically engineered microbe modified to convert acetyl CoA, molecular hydrogen and carbon dioxide to 4-hydroxybutyrate, wherein the 4-hydroxybutyrate is produced at increased levels compared to a control microbe, wherein the microbe is a hyperthermophile, wherein the microbe is a member of the domain Archaea or a member of the domain Bacteria, and wherein the microbe comprises an exogenous polynucleotide encoding a polypeptide, wherein the polypeptide has an activity selected from 3-hydroxypropionate:CoA ligase activity, 3-hydroxypropionyl-CoA dehydratase activity, acryloyl-CoA reductase activity, methylmalonyl-CoA epimerase activity, methylmalonyl-CoA mutase activity, and succinate semialdehyde reductase activity.
US Pat. No. 10,639,299

CALCIUM SENSING RECEPTORS, LIGANDS, COMPOSITIONS, AND METHODS OF USE

Georgia State University ...

1. A method of treating a disease in a subject, the method comprising the step of:administering an amount of L-1,2,3,4-tetrahydronorharman-3-carboxylic acid (TNCA) to the subject in need thereof, wherein the subject has a disease associated with a mutation of the extracellular calcium-binding domain (ECD) of a calcium-sensing receptor protein (CaSR) or a disease associated with abnormal CaSR expression or abnormal CaSR activity in a subject in need thereof.
US Pat. No. 10,398,663

MITOCHONDRIAL DELIVERY OF 3-BROMOPYRUVATE

UNIVERSITY OF GEORGIA RES...

1. A nanoparticle, comprising:a radiation excitable core;
hexokinase-2 inhibitor attached to the radiation excitable core; and
a mitochondrial targeting moiety attached to the radiation excitable core, wherein the mitochondrial targeting moiety comprises a lipophilic delocalized cation.
US Pat. No. 10,588,958

AVIAN REOVIRUS VACCINES

University of Georgia Res...

1. An isolated avian reovirus, wherein the avian reovirus is attenuated by at least 25 passages in an egg or a host cell line and wherein the avian reovirus comprises a sigma C protein comprising an amino acid sequence with at least about 98% sequence identity to SEQ ID NO:6.

US Pat. No. 10,536,415

2?-FLUORO-6?-METHYLENE CARBOCYCLIC NUCLEOSIDES AND METHODS OF TREATING VIRAL INFECTIONS

UNIVERSITY OF GEORGIA RES...

1. A nucleoside compound according to the structure:
Where B is

Wherein
R1 and R1a are each independently, H, an acyl group, a C1-C20 alkyl or ether group, an amino acid residue (D or L), a phosphate, diphosphate, triphosphate, phosphodiester or phosphoramidate group or together R1 and R1a form a carbodiester or phosphodiester group with the oxygen atoms to which they are bonded;
R2 is H, an acyl group, a C1-C20 alkyl or ether group or an amino acid residue (D or L); or
a pharmaceutically acceptable salt, or enantiomer thereof.

US Pat. No. 10,174,132

HEPARAN SULFATE SYNTHESIS

UNIVERSITY OF GEORGIA RES...

1. A library of disaccharides comprising compounds 41, 42, 43, and 44 as follows:

US Pat. No. 10,307,106

SYSTEMS AND METHODS FOR ESTIMATING AND REMOVING MAGNETIC RESONANCE IMAGING GRADIENT FIELD-INDUCED VOLTAGES FROM ELECTROPHYSIOLOGY SIGNALS

UNIVERSITY OF GEORGIA RES...

1. A method for correcting electrophysiology signals by removing voltages induced by magnetic field gradients generated by a magnetic resonance imaging (MRI) system, the steps of the method comprising:(a) providing gradient waveforms;
(b) computing derivatives of the provided gradient waveforms;
(c) acquiring electrophysiology signals from a subject positioned in the MRI system while the MRI system is generating magnetic field gradients based on the provided gradient waveforms;
(d) estimating fitting parameters for a physical model of gradient-induced voltages;
(e) estimating voltages induced by the generated magnetic field gradients by fitting the provided gradient waveforms, the computed derivatives of the gradient waveforms, and the estimated fitting parameters to the physical model of gradient-induced voltages;
(f) removing the estimated gradient-induced voltages from the acquired electrophysiology signals to produce corrected electrophysiology signals; and
(g) displaying the corrected electrophysiological signals on a display.
US Pat. No. 10,196,616

ALTERED AVIAN VIRUS FOR IN-OVO INOCULATION AND METHODS OF USE THEREOF

The United States of Amer...

1. A plasmid encoding an altered Newcastle Disease Virus (NDV) comprising an NDV sequence and a first polynucleotide encoding a reverse, complementary sequence of interleukin 4 (IL-4) or fragment thereof; wherein said altered NDV produces anti-sense RNA of IL-4 or fragment thereof.

US Pat. No. 10,082,519

BERRY IMPACT RECORDING DEVICE

University of Georgia Res...

1. A berry impact recording device, comprising:a waterproof shell;
a battery located within the waterproof shell;
an inductor located within the waterproof shell and electrically coupled to the battery;
a sensor located within the waterproof shell, wherein the sensor is configured to at least:
detect an acceleration of the berry impact recording device;
report the acceleration of the berry impact recording device to an integrated circuit within the waterproof shell;
detect a pressure applied to the berry impact recording device; and
report the pressure applied to the berry impact recording device to the integrated circuit; and
wherein the integrated circuit is configured to at least:
record the acceleration of the berry impact recording device and a timestamp corresponding to when the acceleration was reported or detected; and
record the pressure applied to the berry impact recording device and a timestamp corresponding to when the pressure was reported or detected.
US Pat. No. 10,633,672

GENE FOR INDUCTION OF PARTHENOGENESIS, A COMPONENT OF APOMICTIC REPRODUCTION

University of Georgia Res...

1. A method of propagating from one or more gametophytic or sporophytic cells in an ovule of a plant in the absence of egg cell fertilization, the method comprising:transforming a plant with an ASGR-BBML gene construct comprising a nucleic acid encoding a polypeptide having at least 95% sequence identity to the polypeptide of SEQ ID NO: 4, wherein the nucleic acid is operably linked to a promoter; and
growing and selecting a progeny plant from the one or more gametophytic or sporophytic cells, wherein the progeny plant contains one or more sets of chromosomes from the transformed plant, and wherein propagation of the plant occurs in the absence of egg cell fertilization.
US Pat. No. 10,626,379

PRODUCTION OF VIRUSES IN CELL CULTURE

Commonwealth Scientific a...

1. A method of replicating a virus, the method comprising1) inoculating a population of cells with a virus in vitro, the cells having a genetic modification which reduces the expression of the Interleukin 1 receptor type 1 (IL-1RA) gene in the cells by at least 50% when compared to isogenic cells lacking the genetic modification; and
2) culturing the cells for a predetermined period of time to replicate the virus, wherein the cells are capable of producing more virus than a population of the isogenic cells wherein the virus is an Orthomyxoviridae virus.

US Pat. No. 10,533,008

SYNTHESIS OF 2?-FLUORO-6?-METHYLENE-CARBOCYCLIC ADENOSINE (FMCA) AND 2?-FLUORO-6?-METHYLENE-CARBOCYCLIC GUANOSINE (FMCG)

UNIVERSITY OF GEORGIA RES...

1. A process for preparing the compound 2?-Fluoro-6?-Methylene-Carbocyclic Adenosine (FMCA) compound 10
from compound 8

Comprising condensing an amine protected 6-amino purine compound according to the chemical structure:

where P represents one or two amine protecting groups onto compound 8 in the presence of triphenylphosphine and diisopropylazidocarboxylate (DIAD) in solvent to produce compound 8P

where P represents one or two amine protecting groups; and
subjecting compound 8P to deprotection to produce compound 10 (FMCA)

wherein the synthesis may be conducted in a single pot or in steps, with separation and/or purification to produce either of compounds 8P and compound 10.
US Pat. No. 10,487,042

METHOD FOR SOLVENT-FREE DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION

University of Georgia Res...

1. A solvent-free method for decarboxylation of amino acids to produce an amine via an imine intermediate, the method comprising:(a) combining, in an open reaction vessel, a mixture of an amino acid and a co-reagent, the co-reagent comprising a ketone, enone, enal, aldehyde, or combination thereof, wherein the mixture does not contain a solvent;
(b) heating the mixture at about 150° C., or more, until the mixture becomes homogenous, wherein the amino acid is converted to its imine;
(c) cooling the reaction mixture from step (b) in the reaction vessel to a temperature below about 30° C.;
(d) adding an acid to the cooled reaction mixture from step (c) in the vessel; and
(e) heating the acid reaction mixture from step (d) to about 50° C., or more, to hydrolyze the imine to form an amine salt.

US Pat. No. 10,457,700

PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF

UNIVERSITY OF GEORGIA RES...

1. A compound of Formula I:
wherein L1 and L2 are each —(CH2)n—, where n is 5-15, and LG1 and LG2 are each Cl, Br, or I.

US Pat. No. 10,053,674

METHODS AND COMPOSITIONS USING FUNGAL LACCASES TO REDUCE TURF THATCH

University of Georgia Res...

1. A method of degrading turf thatch, comprising:contacting the turf thatch of an area of turfgrass, where the area of turfgrass forms a ground covering on a plot of land, with a composition comprising an isolated fungal laccase enzyme from a species of white rot fungi selected from: Trametes versicolor and a species from the Pycnoporus genus,
wherein the isolated laccase enzyme composition degrades thatch in the area of turfgrass and wherein the amount of turf thatch in the area of turfgrass, measured as thatch layer thickness, is reduced by a measureable amount after treatment with the isolated laccase enzyme composition, as compared to the amount of turf thatch in the area of turfgrass before treatment.

US Pat. No. 10,676,719

DEVICES AND METHODS FOR SEPARATING PARTICLES

University of Georgia Res...

1. A kit for separating unlabeled rare cells from a sample of whole blood, the kit comprising:a biocompatible magnetic fluid comprising a plurality of un-conjugated, nano-sized magnetic particles having an average diameter of about 5-10 nm, wherein the nano-sized magnetic particles are covered by a surfactant and suspended in a compatible carrier medium and wherein the volume fraction of nano-sized magnetic particles is about 0.2% to about 1%; and
a device comprising:
a serpentine microfluidic channel having a first end and a second end,
a first inlet at the first end of the serpentine microfluidic channel, wherein the first inlet is configured to flow the sample of whole blood into the serpentine microfluidic channel,
a filtration region disposed between the first end and the second end and after the first inlet, wherein the filtration region includes at least one filter in the serpentine microfluidic channel, wherein the filter removes one or both of fibrin and large debris from the sample of whole blood,
a curve along a length of the serpentine microfluidic channel located after the first inlet and the filtration region, wherein the angle of curvature of the curve is about 120° to about 180 °,
a second inlet located after the first inlet, the filtration region, and the curve, wherein the second inlet is configured to flow the biocompatible magnetic fluid into the serpentine microfluidic channel, to combine the magnetic fluid with the sample of whole blood, and to hydrodynamically focus the unlabeled rare cells into a stream by sheath flow,
one or more permanent magnets positioned adjacent and along a length of the serpentine microfluidic channel after the second inlet, wherein the permanent magnets are positioned to form a non-uniform magnetic field that produces a magnetization direction perpendicular to the flow of the stream containing the unlabeled rare cells such that the unlabeled rare cells and other components of the sample of whole blood experience a magnetic buoyancy force that causes the unlabeled rare cells and other components to spatially separate from one another in the microfluidic channel based on particle volume, and
two or more outlet channels positioned after the one or more permanent magnets at the second end of the microfluidic channel, wherein the unlabeled rare cells are separated from the sample of whole blood and into one of the two or more outlets with an average separation efficiency of greater than 65% when operated at a flow rate of about 20 ?/min to about 100 ?/min; and
wherein the unlabeled rare cells are still alive when they are separated from the sample of whole blood.
US Pat. No. 10,494,493

NITRIC OXIDE-RELEASING PACKAGING MEMBRANES

University of Georgia Res...

1. A multilayer packaging film comprisingat least one layer comprising:
an antibacterially effective amount of a monomer or polymer comprising an S-nitrosothiol group, wherein the weight percent of the monomer or polymer is from about 0.1% to about 10%; and
about 90-99.9 weight percent of a biodegradable polymer comprising a nanocelluslose and a chitosan, wherein the weight ratio of chitosan to nanocellulose is from 10:1 to 1:10.
US Pat. No. 10,260,054

ENGINEERED ORGANOPHOSPHORUS ACID ANHYDROLASES AND METHODS OF USE THEREOF

University of Georgia Res...

1. A genetically engineered organophosphorous acid anhydrolase (OPAA) polypeptide, wherein the genetically engineered OPPA polypeptide has broadened substrate specificity relative to the OPPA polypeptide of SEQ ID NO:5 by replacing at least one basic amino acid within the small pocket of the OPAA with an acidic amino acid or its amide,wherein the OPPA comprises an amino acid sequence at least 90% identical to the region from amino acid residue 212 to residue 343 of SEQ ID NO:12, and
wherein the amino acid at the residue corresponding to residue 343 of SEQ ID NO:12 is not a histidine.

US Pat. No. 10,548,993

METAL-ENCAPSULATED CARBONACEOUS DOTS

UNIVERSITY OF GEORGIA RES...

1. A nanoparticle, comprising: gadolinium encapsulated in an amorphous carbon shell, wherein the shell comprises carboxyl groups and wherein the average diameter of the nanoparticle is from about 2 nm to about 34 nm.
US Pat. No. 10,266,859

MICROBIAL APPROACH FOR THE PRODUCTION OF 5-HYDROXYTRYPTOPHAN

UNIVERSITY OF GEORGIA RES...

1. A genetically engineered bacterial cell comprising a modified bacterial phenylalanine-4-hydroxylase (P4H) wherein the modified P4H catalyzes the 5-hydroxylation of tryptophan in the presence of a tetrahydromonapterin (MH4) cofactor, and in the absence of a tetrahydrobiopterin (BH4) cofactor or 6,7-dimethyl-5,6,7,8-tetrahydropterine hydrochloride, wherein the modified bacterial P4H comprises an amino acid mutation at any one, any two, or all three of amino acid positions 98, 179, and 231 of X. campestris P4H (SEQ ID NO:1), or at any one, any two, or all three corresponding amino acid positions in a bacterial P4H enzyme from another species.
US Pat. No. 10,646,570

INDUCED PHOTODYNAMIC THERAPY USING NANOPARTICLE SCINTILLATORS AS TRANSDUCERS

UNIVERSITY OF GEORGIA RES...

1. A photodynamic therapy system, comprising:(a) a strontium aluminum oxide nanoparticle of formula SraAlbOc, where a, b and c are integers from 1 to 30, doped with Eu2+, Dy3+, Nd3+, or combinations thereof that emits electromagnetic radiation having a first wavelength when irradiated with electromagnetic radiation having a second wavelength and wherein nanoparticle is from 5 nm to 5000 nm;
(b) a photosensitizer which absorbs electromagnetic radiation of said first wavelength;
(c) a first shell comprising a biocompatible mesoporous silica that forms a coating on the surface of the nanoparticle; and
(d) a second shell comprising a solid layer of silica, wherein the second shell is between the first shell and the surface of the nanoparticle or the second shell surrounds the first shell,
wherein the photosensitizer is embedded in the mesoporous silica.

US Pat. No. 10,328,182

COMPOSITIONS AND METHODS FOR REDUCING NEOINTIMA FORMATION

University of Georgia Res...

1. A method of reducing proliferation of vascular smooth muscle cells or reducing neointima formation in a subject comprising implanting into the subject a medical device comprising an effective amount of a CTP synthase 1 (CTPS1) inhibitor to reduce proliferation of vascular smooth muscle cells (VSMC) in the subject to a greater degree than the inhibitor reduces endothelial cell proliferation in the subject,wherein the CTPS1 inhibitor is a nucleoside analog.
US Pat. No. 10,238,062

METHODS TO IDENTIFY SOYBEAN APHID RESISTANT QUANTITATIVE TRAIT LOCI IN SOYBEAN AND COMPOSITIONS THEREOF

Monsanto Technology LLC, ...

1. A method of producing an aphid resistant population of soybean plants, the method comprising:A) Genotyping at least one soybean plant from a first population of soybean plants with respect to a soybean genomic nucleic acid marker selected from the group consisting of SEQ ID NO: 100, 101, and 102, wherein said nucleic acid marker is indicative of an allele conferring aphid resistance in a soybean plant,
B) Selecting at least one soybean plant from the first population based upon said genotyping for the presence of said allele conferring resistance in a soybean plant, and
C) Crossing the selected soybean plant having said allele conferring aphid resistance with an aphid susceptible soybean plant to produce a second population of soybean plants having aphid resistance,
thereby creating an aphid resistant population of soybean plants comprising a soybean genomic nucleic acid marker selected from the group consisting of SEQ ID NO: 100, 101, and 102, wherein said nucleic acid marker is indicative of an allele conferring aphid resistance in a soybean plant.
US Pat. No. 10,741,863

ENGINEERED PHOTOSYNTHETIC ORGANISMS, PHOTOSYNTHETIC ELECTRODES INCLUDING THE ENGINEERED PHOTOSYNTHETIC ORGANISMS, PHOTOSYNTHETIC BIOELECTROCHEMICAL CELLS AND PHOTOSYNTHETIC FUEL CELLS

University of Georgia Res...

1. An engineered photosynthetic cyanobacterium comprising:an exogenous nucleic acid molecule encoding a non-native multi-heme outer membrane cytochrome (Omc) from an exoelectrogenic organism and capable of extracellular electron transport, and
a promoter operatively linked to the exogenous nucleic acid molecule encoding the Omc, such that the Omc is expressed in the cyanobacterium into which it is transformed,
wherein the engineered photosynthetic cyanobacterium has increased extracellular electron transport compared to a corresponding wild-type cyanobacterium that does not comprise the exogenous nucleic acid molecule encoding the non-native Omc capable of extracellular electron transport.
US Pat. No. 10,307,435

EXERCISE PERFORMANCE ENHANCERS

University of Georgia Res...

1. A method for enhancing exercise performance in a subject, comprising contacting the oral cavity of the subject with a composition comprising a sweet and caloric food product for a period of 5 seconds to 60 seconds without ingestion of the food product, wherein the oral cavity of the subject is contacted with the composition after fasting intervals of at least 6 to 10 minutes.

US Pat. No. 10,541,661

CONTINUOUSLY TUNABLE AND HIGHLY RECONFIGURABLE MULTIBAND RF FILTER

University of Georgia Res...

1. A multiband radio frequency (RF) filter, comprising:a Lyot loop filter comprising a tunable birefringence loop comprising a circulator, a birefringent device, and a polarization controller (PC), the Lyot loop filter configured to generate an optical comb based at least in part upon an input optical signal, the birefringent device, and a polarization rotation angle of the PC; and
a tunable Mach-Zehnder interferometer (MZI) providing the input optical signal to the Lyot loop filter, the tunable MZI comprising a tunable delay line configured to adjust comb spacing of the optical comb.
US Pat. No. 10,770,183

METHODS OF ASSESSING A RISK OF DEVELOPING NECROTIZING MENINGOENCEPHALITIS

The Translational Genomic...

6. A method for breeding a canine subject to reduce propensity to necrotizing meningoencephalitis (NME) in progeny resulting from the breeding, the method comprising:extracting genomic DNA from a sample from the canine subject;
assaying the genomic DNA for one or more single nucleotide polymorphisms (SNPs), wherein the SNPs comprise BICF2G630168244 corresponding to position 74522353 on canine chromosome 4 and rs8954494 corresponding to position 53338796 on canine chromosome 15;
detecting a T allele at BICF2G630168244 and an A allele at rs8954494 in the genomic DNA from the sample; and
breeding the canine subject with the T allele at BICF2G630168244 and the A allele at rs8954494 in the genomic DNA from the sample.

US Pat. No. 10,432,304

PHOTONIC IMPLEMENTATION OF JAMMING AVOIDANCE RESPONSE

University of Georgia Res...

1. A jamming avoidance response (JAR) system, comprising:circuitry configured to transmit a reference signal and receive an interference signal;
photonic circuitry configured to generate optical spikes corresponding to positive zero crossing points of the reference signal; and
photonic circuitry configured to provide a phase output that indicates whether a beat signal associated with the interference signal and the reference signal is leading or lagging the reference signal, the phase output based at least in part upon the optical spikes and the beat signal.
US Pat. No. 10,329,538

LIVE ATTENUATED ARKANSAS SEROTYPE INFECTIOUS BRONCHITIS VIRUS VACCINE

UNIVERSITY OF GEORGIA RES...

1. An infectious bronchitis virus (IBV) isolate, wherein the IBV isolate comprises the IBV isolate ArkGA p60 deposited at the ATCC under Patent Designation PTA-123783.
US Pat. No. 10,329,585

PIV5 AS AN ONCOLYTIC AGENT

UNIVERSITY OF GEORGIA RES...

1. A method of inducing tumor cell syncytia formation in a subject with a tumor, the method comprising administering to the subject a composition comprising an isolated parainfluenza virus 5 (PIV5) mutant in an amount effective to induce tumor cell syncytia, wherein the PIV5 mutant comprises a mutation lacking the C-terminus of the V protein (rPIV5VAC) and further comprises a heterologous nucleotide sequence encoding a tumor killing heterologous polypeptide and/or heterologous RNA.
US Pat. No. 10,881,072

SOYBEAN PLANT NAMED ‘G13LL-44’

University of Georgia Res...

1. A seed of soybean variety ‘G13LL-44’, wherein a representative sample of seed of the variety has been deposited under American Type Culture Collection (ATCC) Accession No. PTA-126862.

US Pat. No. 10,587,938

ULTRA HIGH-SPEED PHOTONICS BASED RADIO FREQUENCY SWITCHING

University of Georgia Res...

14. A method, comprising:modulating an input radio frequency (RF) signal onto an optical carrier to generate a single-sideband (SSB) signal;
notch filtering the SSB signal by a tunable phase modulator incorporated loop mirror filter (PM-LMF) in response to a control signal, wherein the tunable PM-LMF switches between notch filtering at a first frequency and notch filtering at a second frequency in response to the control signal; and
generating a RF output signal based upon the SSB signal.

US Pat. No. 10,526,633

ELECTROCHEMICAL SENSORS AND METHODS FOR USING ELECTROCHEMICAL SENSORS TO DETECT PLANT PATHOGEN INFECTION

UNIVERSITY OF GEORGIA RES...

19. A method for monitoring a condition of a plant or crop of plants, the method comprising:(1) periodically sampling volatile emissions from the plant or one or more crop plants using a plant volatile detection system, the plant volatile detection system comprising:
(a) a volatile collection reservoir adapted to collect volatile compounds emitted from a plant;
(b) an electrochemical sensor comprising:
(i) an electrochemical cell comprising:
at least two volatile detection electrodes in fluid communication with the volatile collection reservoir such that volatile compounds collected in the reservoir can be transferred to a detection surface of each volatile detection electrode, each volatile detection electrode having an electrode substrate and a bio-nanocomposite detection element on a detection surface of the electrode substrate and in electrochemical communication with the electrode substrate, the bio-nanocomposite detection element having a nanomaterial transducer material and one or more enzymes capable of specific reaction with a stress-induced plant volatile compound or its hydrolysis product, a plant-pathogen emitted volatile compound or its hydrolysis product, or both, wherein the one or more enzymes are immobilized to the nanomaterial transducer material, and wherein at least one volatile detection electrode detects a different target volatile compound than at least one other volatile detection electrode,
a counter electrode, and
a reference electrode, both the counter electrode and the reference electrode in electrochemical communication with the volatile detection electrode; and
(ii) a potentiostat to supply an electric current to the electrochemical cell and monitor changes in the electric current produced at the volatile detection electrode; and
(c) a signal processing mechanism in operative communication with one or more elements of the electrochemical sensor, the signal processing mechanism having data transfer and evaluation software protocols configured to transform raw data from the electrochemical sensor into diagnostic information regarding the presence or absence or levels of the plant volatile compound; and
(2) determining the presence of a plant disease associated with the one or more volatile compounds based on the information provided by the signal processing mechanism regarding the presence or absence or levels of the plant volatile compound.
US Pat. No. 10,501,726

POPULATION OF ISOLATED CHICKEN CELLS REPROGRAMMED FROM SOMATIC CELLS

UNIVERSITY OF GEORGIA RES...

1. A population of isolated chicken cells which have been reprogrammed from chicken somatic cells, wherein said isolated chicken cells comprise exogenous nucleic acid sequences encoding OCT4, SOX2, LIN28 and NANOG genes, and wherein said isolated cells exhibit the following characteristics:the cells express Alkaline Phosphotase, SSEA1, EMA1, Chicken Vasa Homolog (CVH), DAZL, CXCR4, C-KIT and telomerase; and
the cells are capable of differentiating into all 3 germ layers in vitro.

US Pat. No. 10,898,307

SYSTEM AND METHOD FOR FOWL VACCINATION

University of Georgia Res...

1. A method for vaccinating fowl in need thereof comprising wetting a population of fowl with an effective amount of a refrigerated pressurized aqueous composition,the aqueous composition comprising a vaccination agent wherein the aqueous composition is applied at a substantially constant temperature sufficient to maintain a concentration of the vaccination agent during wetting via a vessel configured to contain a pressurized aqueous vaccination composition;
wherein the population of fowl is continuously transported;
wherein the aqueous composition is applied via a valve at a substantially constant pressure and flow rate and for a duration of time that is a function of a speed at which the population of fowl passes by a nozzle dispersing the aqueous composition;
wherein the nozzle is in fluid communication with the valve, the valve remaining open for a duration of the continuous transport; and
wherein the substantially constant pressure is from about 30 psi to about 50 psi.
US Pat. No. 11,027,008

RECOMBINANT MUMPS VIRUS VACCINE

UNIVERSITY OF GEORGIA RES...

1. A live-attenuated recombinant mumps virus (rMuV) comprising one or more mutations to the V/I/P gene abrogating expression of the V protein compared to a parent mumps virus from which the live-attenuated rMuV is mutated.

US Pat. No. 10,995,093

SYNTHESIS OF 2?-FLUORO-6?-METHYLENE-CARBOCYCLIC ADENOSINE (FMCA) AND 2?-FLUORO-6?METHYLENE-CARBOCYCLIC GUANOSINE (FMCG)

UNIVERSITY OF GEORGIA RES...

1. A process for preparing the compound 2?-Fluoro-6?-Methylene-Carbocyclic Adenosine (FMCA) compound 10 from compound 8
Comprising condensing an amine protected 6-amino purine compound according to the chemical structure:

where P represents one or two amine protecting groups (preferably two BOC groups) onto compound 8 in the presence of triphenylphosphine and diisopropylazidocarboxylate (DIAD) in solvent to produce compound 8P

where P represents one or two amine protecting groups; and
subjecting compound 8P to deprotection to produce compound 10 (FMCA)

wherein the synthesis is conducted in steps, wherein both compound 8P and 10 are separated and purified.
US Pat. No. 10,907,133

PRODUCTION OF VIRUSES IN AVIAN EGGS

Commonwealth Scientific a...

1. An avian egg comprising a genetic modification which reduces the expression of an antiviral gene in the egg when compared to an isogenic egg lacking the genetic modification, wherein the antiviral gene is selected from IL-1RA, IL-6, CNOT4, BACE2, UBA5, ZFPM2, TRIM50, DDI2, NPR2, CAPN13, DNASE1L2, PHF21A, PCGF5, LAMP1, EFR3A, ABI1, GADL1, PLVAP, CYYR1, ASAP1, NXF1, NSUN6, ANGPTL7, SIL1, BCAR3, GOLPH3L, HN1, ADCY7, CBLN4, CXORF56, DDX10, EIF2S3, ESF1, GCOM1, GTPBP4, IFT43, KPNA3, LRRIQ1, LUC7L, MRPL12, PWP2, RPL7A, SMYD2, XPO1 and ZKSCAN7.
US Pat. No. 10,905,678

SITE-SPECIFIC ANTIBODY-DRUG GLYCOCONJUGATES AND METHODS

UNIVERSITY OF GEORGIA RES...

1. An antibody-drug conjugate thereof, comprising at least one N-linked oligosaccharide comprising at least one terminal sialoside, said terminal sialoside covalently linked to a cytotoxic drug, wherein said N-linked oligosaccharide is glycosylated to an IgG-class antibody through an asparagine residue in the heavy chain,wherein the linker comprises a cycloaddition product between a 1,3 dipole and strained alkyne or alkene.
US Pat. No. 10,883,086

METHODS AND COMPOSITIONS RELATED TO INCREASED INFLUENZA VIRUS PRODUCTION

University of Georgia Res...

1. An in vitro method of increasing influenza virus production of one or more influenza viruses comprising infecting a cell with an influenza virus; wherein the cell comprises reduced expression of at least one gene selected from HD, PLA2G1B, PYCR1, EMX2, FGF2, RHOBTB2, B4GALT2, ALOXE3, ADAMTS6, TRIM4, NRF1, SIM1, SOX10, CYP17A1, GPR155, GPR115, UGT1A3, TYR, F1114466, TMPRSS6, TRUB1, GCNT2, RFP2, PRDX6, MYO7A, ACCN2, CNGA4, WBSCR27, PYGL, ANXA9, MAK3, RBP4, PCGF1, ERCC6, ORAI1, ZNF205, and DUSP19 genes.

US Pat. No. 10,870,710

SYNTHETIC OLIGOSACCHARIDE SUBUNITS OF THE PSL EXOPOLYSACCHARIDE OF PSEUDOMONAS AERUGINOSA AND USES THEREOF

MedImmune Limited, Cambr...

1. A method comprising
(a) reacting a thiomannosyl donor 7 with acceptor

saccharide 10 to form disaccharide 13, and then partially deprotecting disaccharide 13 to form disaccharide 14:

(b) reacting disaccharide 14 and with thiomannoside 8
to form trisaccharide 15 then partially deprotecting the trisaccharide to form compound 16,then reacting compound 16 with CC13 CN, and Cs2 CO3, in dichloromethane to form the trichloroacetimidate trisaccharide 17:and
(c) reacting the trichloroacetimidate trisaccharide 17 with compound 12in the presence of trimethylsilyl trifluoromethanesulfonate and dichloromethane at ?30° C. to form a linear tetrasaccharide 18then partially deprotecting linear tetrasaccharide 18 with hydrofluoric acid in pyridine to form the linear tetrasaccharide 19:
and wherein Nap is 2-methylnaphthyl, Ph is a phenyl group, Bn is a benzyl group, Bz is a benzoyl group, All is allyl ether, and TBS is t-butyldimethylsilyl.
US Pat. No. 10,822,380

DISRUPTION OF THE WAVE3 PROTEIN COMPLEX FOR SUPPRESSION OF INVASION AND METASTASIS

University of Georgia Res...

1. A synthetic polypeptide, comprising an amino acid sequence that comprises SEQ ID NO: 1 or SEQ ID NO: 2.
US Pat. No. 10,752,916

PARAINFLUENZA VIRUS 5 BASED VACCINES

UNIVERSITY OF GEORGIA RES...

1. A viral expression vector comprising a parainfluenza virus 5 (PIV5) genome comprising a heterologous nucleotide sequence expressing a heterologous polypeptide, wherein the heterologous nucleotide sequence replaces the small hydrophobic (SH) gene nucleotide sequence of the PIV5 genome, and wherein the heterologous polypeptide is not derived from mumps virus.
US Pat. No. 10,731,185

GENETICALLY ENGINEERED MICROBES AND METHODS FOR PRODUCING CITRAMALATE

UNIVERSITY OF GEORGIA RES...

1. A genetically engineered microbe which accumulates citramalate,wherein the microbe comprises a first exogenous polynucleotide encoding a citramalate synthase which catalyzes the condensation of acetyl CoA and pyruvic acid, and
wherein the microbe comprises a second exogenous polynucleotide encoding a citrate synthase which catalyzes the condensation of acetyl CoA and oxaloacetate, and the citrate synthase activity in the microbe is reduced compared to a control microbe.
US Pat. No. 10,416,167

NANOPARTICLES FOR MITOCHONDRIAL TRAFFICKING OF AGENTS

University of Georgia Res...

1. A nanoparticle, comprising:a hydrophobic nanoparticle core;
a hydrophilic layer surrounding the core; and
a mitochondria targeting moiety tethered to the core,
wherein the nanoparticle has a diameter of from about 10 nanometers to about 200 nanometers or less and has a zeta potential of about 0 mV or greater.
US Pat. No. 10,358,637

CARBOHYDRATE-BINDING PROTEIN

University of Georgia Res...

1. An isolated catalytically inactive carbohydrate-binding PNGase F protein with binding specificity and affinity to an O-linked glycan, said protein having a plurality of amino acid mutations compared to a corresponding wild-type PNGase F protein, said plurality of mutations comprising(a) at least one first mutation that reduces or eliminates the catalytic activity of the PNGase F protein; and
(b) at least one second mutation that provides binding specificity and affinity to an O-linked glycan;
wherein the at least one second mutation comprises an amino acid substitution at position D57 of SEQ ID NO: 1, or a corresponding position in a homologous PNGase F sequence, with leucine, alanine, methionine, arginine, lysine, cysteine, or tryptophan.

US Pat. No. 11,062,607

SYSTEMS AND METHODS FOR QUANTITATIVELY ASSESSING COLLISION RISK AND SEVERITY

Kennesaw State University...


1. A method comprising:receiving, by a first computing device, image data associated with a first body and a second body;
determining, based on the image data, an affinity to collision of the first body and the second body, wherein the determining the affinity to collision is further based at least on a displacement between the first body and the second body determined from the image data;
determining, based on the determined affinity to collision, a proximity to collision of the first body and the second body;
determining, based on the determined proximity to collision, a collision risk of the first body and the second body; and
transmitting, to a second computing device, an indication of the determined collision risk.

US Pat. No. 10,989,865

STRETCHABLE FIBER OPTIC SENSOR

UNIVERSITY OF GEORGIA RES...

1. A fiber optic sensor, comprising:a deformable silicone substrate; and
an optical fiber comprising a single core, the optical fiber being embedded within and bonded to the deformable silicone substrate, the optical fiber comprising fiber Bragg gratings (FBG), and the optical fiber being embedded within the deformable silicone substrate in a sinusoidal shape, wherein the sinusoidal shape is configured to enable stretching and elongation of the fiber optic sensor by up to about thirty percent by unfolding the optical fiber in a manner that avoids its delamination from the deformable silicone substrate.
US Pat. No. 10,953,036

COMPOSITIONS AND METHODS OF MODULATING HIF-2A TO IMPROVE MUSCLE GENERATION AND REPAIR

UNIVERSITY OF GEORGIA RES...

1. A method of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof comprising administering the subject an effective amount of HIF-2? inhibitor.

US Pat. No. 10,800,989

METHODS OF IGNITING A FUEL SOURCE, LIGHTER FLUID COMPOSITIONS AND SELF-LIGHTING CHARCOAL BRIQUETTES

University of Georgia Res...

1. A method of igniting a fuel source, the method comprising:contacting a fuel source with a lighter fluid composition comprising a fusel oil component comprising one or more dehydration products of fusel oil, wherein the dehydration products include a multicomponent alcohol mixture, and
igniting the lighter fluid composition.
US Pat. No. 10,787,678

CADHERIN FRAGMENTS FOR MANAGING INSECT RESISTANCE TO CRY PROTEINS

University of Georgia Res...

1. An expression vector comprising DNA that encodes an AdCad1 fragment, wherein the AdCad1 fragment consists of: a polypeptide with at least 95% sequence identity with AdCad1-CR9 (SEQ ID NO: 4); or a polypeptide with at least 95% sequence identity with AdCad1-MPED (SEQ ID NO: 6).