US Pat. No. 9,353,143

ECDYSTERONE COMPOUNDS

ThermoLife International,...

1. A method for increasing in a human one of: bioavailability of ecdysterone; half-life of ecdysterone; and distribution to
skeletal muscle tissue of ecdysterone, the method comprising administering an effective amount of a physiologically active
ester of ecdysterone to the human.

US Pat. No. 9,662,304

SUBSTITUTED GLUTAURINE COMPOUNDS AND SUBSTITUTED GLUTAURINE DERIVATIVES

ThermoLife International,...

1. A compound of Formula Id:

or a salt thereof.
US Pat. No. 9,573,883

SALTS OF CARNITINE DERIVATIVES AND METHODS OF PRODUCTION

ThermoLife International,...

1. A method of producing acetyl-L-carnitine nitrate comprising:
reacting L-carnitine with acetic anhydride to produce acetyl-L-carnitine free base;
isolating the acetyl-L-carnitine free base;
reacting the acetyl-L-carnitine free base with nitric acid to produce acetyl-L-carnitine nitrate; and
isolating the acetyl-L-carnitine nitrate,
wherein reacting L-carnitine with acetic anhydride to produce acetyl-L-carnitine free base comprises dissolving the L-carnitine
in acetic acid, and wherein the reaction between L-carnitine and acetic anhydride occurs at a temperature of between 30° C.
and 80° C.

US Pat. No. 10,426,750

AMINO ACID SUPPLEMENT FORMULATIONS

ThermoLife International,...

1. A supplement formulation for ingestion comprising:a nitrate of a compound selected from the group consisting of: agmatine, beta alanine, citrulline, creatine, glutamine, isoleucine, norvaline, ornithine, aspartic acid, cysteine, glycine, lysine, proline, tyrosine, and phenylalanine, wherein the nitrate of the compound is a salt of nitric acid (NO3?) or a mixed salt of nitric acid (NO3?); and
one or more additional components selected from the group consisting of: a binder, a colorant, and a flavoring agent,
wherein the supplement formulation is formulated to deliver an effective amount of the nitrate of the compound to ameliorate tolerance to dilator effects of nitrates, to increase bioabsorption of the compound, to increase the vasodilative characteristics of the compound, or to increase athletic performance in a human or animal.
US Pat. No. 10,100,003

SALTS OF CARNITINE DERIVATIVES AND METHODS OF PRODUCTION

Thermolife International,...

1. A method of producing acetyl-L-carnitine nitrate comprising:reacting L-carnitine with acetic anhydride to produce acetyl-L-carnitine free base;
isolating the acetyl-L-carnitine free base;
reacting the acetyl-L-carnitine free base with nitric acid to produce acetyl-L-carnitine nitrate; and
isolating the acetyl-L-carnitine nitrate, wherein the step comprises.
distilling the reaction of acetyl-L-carnitine free base and nitric acid to remove the other products of the reaction;
washing the acetyl-L-carnitine nitrate with acetone; and
crystallizing the acetyl-L-carnitine nitrate.
US Pat. No. 10,435,356

AMINO ACID COMPOSITIONS

ThermoLife International,...

1. A composition for ingestion by a human, the composition comprising:a solid nitrate of a compound selected from the group consisting of agmatine, beta alanine, citrulline, creatine, glutamine, isoleucine, norvaline, ornithine, aspartic acid, cysteine, glycine, lysine, proline, tyrosine, and phenylalanine, wherein the nitrate of a compound is a salt of nitric acid (NO3—) or a mixed salt of nitric acid (NO3—), and
at least one pharmaceutically acceptable additive,
wherein the composition is formulated to ameliorate tolerance to dilator effects of nitrates, to increase bioabsorption of the compound, to increase the vasodilative characteristics of the compound, or to increase athletic performance in the human.
US Pat. No. 10,420,739

GLUTAURINE COMPOSITIONS AND THERAPEUTIC USES THEREOF

ThermoLife International,...

1. A method of regulating body weight comprising administering about 500-1000 mcg per day of glutaurine to an obese human subject.
US Pat. No. 10,472,322

AMINO ACID SUPPLEMENT FORMULATIONS

THERMOLIFE INTERNATIONAL,...

1. A supplement formulation for human ingestion comprising a nitrate of a compound selected from the group consisting of agmatine, citrulline, and norvaline, wherein the nitrate of the compound is a salt of a nitrate (NO3?) or a mixed salt of a nitrate (NO3?) and wherein the nitrate of the compound is a solid compound at standard ambient temperature and pressure.
US Pat. No. 10,426,792

AMINO ACID COMPOSITIONS

ThermoLife International,...

1. A composition or a supplement formulation for human ingestion comprising a nitrate of a compound selected from the group consisting of: carnitine, taurine, acetyl derivative of carnitine, acetyl derivative of taurine, propionyl derivative of carnitine, and propionyl derivative of taurine, wherein the nitrate is a salt of nitrate or a mixed salt of nitrate.
US Pat. No. 10,485,777

AMINO ACID COMPOSITIONS

THERMOLIFE INTERNATIONAL,...

1. A composition for human ingestion comprising a nitrate of a compound selected from the group consisting of agmatine, citrulline, and norvaline, wherein the nitrate of the compound is a salt of a nitric acid (NO3?) or a mixed salt of a nitric acid (NO3?) and is a solid at standard ambient temperature and pressure.
US Pat. No. 10,555,921

AMINO ACID COMPOSITIONS

ThermoLife International,...

1. An oral composition for human ingestion comprising:at least one isolated nitrate salt selected from the group consisting of a salt of an amino acid and an inorganic nitrate salt; and
at least one constituent amino acid selected from the group consisting arginine, agmatine, beta alanine, citrulline, creatine, glutamine, L-histidine, isoleucine, leucine, norvaline, ornithine, valine, aspartic acid, cysteine, glycine, lysine, methionine, proline, tyrosine, and phenylalanine,
wherein the isolated nitrate salt is a separate constituent from the at least one constituent amino acid and the oral composition is in a dosage form selected from the group consisting of a capsule, a cachet, a pill, a tablet, a pellet, a bead, a troche, a lozenge, and a gel.

US Pat. No. 10,471,032

SUBSTITUTED GLUTAURINE COMPOUNDS AND SUBSTITUTED GLUTAURINE DERIVATIVES

THERMOLIFE INTERNATIONAL,...

1. A compound selected from the group consisting of:
and
a salt of any of the foregoing.
US Pat. No. 10,702,796

ENRICHED ROOT POWDER PRODUCTS AND METHODS OF PRODUCING THEREOF

THERMOLIFE INTERNATIONAL,...

1. A method of increasing nitrate content and reducing sugar content in dried beetroot product, the method comprising:mixing dried beetroot product with an extraction mixture comprising an alcohol and an acid, wherein the alcohol is a low molecular weight alcohol that is liquid at room temperature;
steeping the mixture of the dried beetroot product and the extraction mixture to produce a steeped mixture;
filtering the steeped mixture to produce a filtered product; and
drying the filtered product to produce a dried filtered product, wherein the nitrate content of the dried filtered product is greater than the nitrate content of the dried beetroot product and the sugar content of the dried filtered product is less than the sugar content of the dried beetroot product.
US Pat. No. 10,646,508

METHOD OF SAFELY ADMINISTERING NITRATE DIETARY SUPPLEMENTS AND COMPOSITIONS

THERMOLIFE INTERNATIONAL,...

1. A method of safely administering to a subject a nitrate with a reduced side effect, the method comprising:combining a quantity of an inorganic nitrate with a quantity of an amino acid compound to produce a composition or a dietary supplement comprising an amino acid nitrate salt, wherein the combining of the inorganic nitrate salt with the amino acid compound reduces the side effect or toxicity of the inorganic nitrate; and
orally administering to the subject the composition or dietary supplement, wherein the subject has reduced side effect or toxicity from the inorganic nitrate and the quantity of the amino acid compound is at least the quantity of the inorganic nitrate,
wherein the side effect is selected from the group consisting of nausea, gastric distress, gastric ulcer, diarrhea, abdominal pain, and methemoglobinemia, and the amino acid compound is selected from the group consisting of agmatine, arginine, asparagine, aspartic acid, beta alanine, betaine, carnitine, citrulline, creatine, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, norvaline, phenylalanine, ornithine, proline, taurine, tyrosine, and valine.