US Pat. No. 9,662,304

SUBSTITUTED GLUTAURINE COMPOUNDS AND SUBSTITUTED GLUTAURINE DERIVATIVES

ThermoLife International,...

1. A compound of Formula Id:

or a salt thereof.
US Pat. No. 9,353,143

ECDYSTERONE COMPOUNDS

ThermoLife International,...

1. A method for increasing in a human one of: bioavailability of ecdysterone; half-life of ecdysterone; and distribution to
skeletal muscle tissue of ecdysterone, the method comprising administering an effective amount of a physiologically active
ester of ecdysterone to the human.
US Pat. No. 9,573,883

SALTS OF CARNITINE DERIVATIVES AND METHODS OF PRODUCTION

ThermoLife International,...

1. A method of producing acetyl-L-carnitine nitrate comprising:
reacting L-carnitine with acetic anhydride to produce acetyl-L-carnitine free base;
isolating the acetyl-L-carnitine free base;
reacting the acetyl-L-carnitine free base with nitric acid to produce acetyl-L-carnitine nitrate; and
isolating the acetyl-L-carnitine nitrate,
wherein reacting L-carnitine with acetic anhydride to produce acetyl-L-carnitine free base comprises dissolving the L-carnitine
in acetic acid, and wherein the reaction between L-carnitine and acetic anhydride occurs at a temperature of between 30° C.
and 80° C.

US Pat. No. 10,435,356

AMINO ACID COMPOSITIONS

ThermoLife International,...

1. A composition for ingestion by a human, the composition comprising:a solid nitrate of a compound selected from the group consisting of agmatine, beta alanine, citrulline, creatine, glutamine, isoleucine, norvaline, ornithine, aspartic acid, cysteine, glycine, lysine, proline, tyrosine, and phenylalanine, wherein the nitrate of a compound is a salt of nitric acid (NO3—) or a mixed salt of nitric acid (NO3—), and
at least one pharmaceutically acceptable additive,
wherein the composition is formulated to ameliorate tolerance to dilator effects of nitrates, to increase bioabsorption of the compound, to increase the vasodilative characteristics of the compound, or to increase athletic performance in the human.
US Pat. No. 10,100,003

SALTS OF CARNITINE DERIVATIVES AND METHODS OF PRODUCTION

Thermolife International,...

1. A method of producing acetyl-L-carnitine nitrate comprising:reacting L-carnitine with acetic anhydride to produce acetyl-L-carnitine free base;
isolating the acetyl-L-carnitine free base;
reacting the acetyl-L-carnitine free base with nitric acid to produce acetyl-L-carnitine nitrate; and
isolating the acetyl-L-carnitine nitrate, wherein the step comprises.
distilling the reaction of acetyl-L-carnitine free base and nitric acid to remove the other products of the reaction;
washing the acetyl-L-carnitine nitrate with acetone; and
crystallizing the acetyl-L-carnitine nitrate.
US Pat. No. 10,426,750

AMINO ACID SUPPLEMENT FORMULATIONS

ThermoLife International,...

1. A supplement formulation for ingestion comprising:a nitrate of a compound selected from the group consisting of: agmatine, beta alanine, citrulline, creatine, glutamine, isoleucine, norvaline, ornithine, aspartic acid, cysteine, glycine, lysine, proline, tyrosine, and phenylalanine, wherein the nitrate of the compound is a salt of nitric acid (NO3?) or a mixed salt of nitric acid (NO3?); and
one or more additional components selected from the group consisting of: a binder, a colorant, and a flavoring agent,
wherein the supplement formulation is formulated to deliver an effective amount of the nitrate of the compound to ameliorate tolerance to dilator effects of nitrates, to increase bioabsorption of the compound, to increase the vasodilative characteristics of the compound, or to increase athletic performance in a human or animal.
US Pat. No. 10,426,792

AMINO ACID COMPOSITIONS

ThermoLife International,...

1. A composition or a supplement formulation for human ingestion comprising a nitrate of a compound selected from the group consisting of: carnitine, taurine, acetyl derivative of carnitine, acetyl derivative of taurine, propionyl derivative of carnitine, and propionyl derivative of taurine, wherein the nitrate is a salt of nitrate or a mixed salt of nitrate.
US Pat. No. 10,420,739

GLUTAURINE COMPOSITIONS AND THERAPEUTIC USES THEREOF

ThermoLife International,...

1. A method of regulating body weight comprising administering about 500-1000 mcg per day of glutaurine to an obese human subject.

US Pat. No. 10,471,032

SUBSTITUTED GLUTAURINE COMPOUNDS AND SUBSTITUTED GLUTAURINE DERIVATIVES

THERMOLIFE INTERNATIONAL,...

1. A compound selected from the group consisting of:
and
a salt of any of the foregoing.
US Pat. No. 10,472,322

AMINO ACID SUPPLEMENT FORMULATIONS

THERMOLIFE INTERNATIONAL,...

1. A supplement formulation for human ingestion comprising a nitrate of a compound selected from the group consisting of agmatine, citrulline, and norvaline, wherein the nitrate of the compound is a salt of a nitrate (NO3?) or a mixed salt of a nitrate (NO3?) and wherein the nitrate of the compound is a solid compound at standard ambient temperature and pressure.