US Pat. No. 9,198,365

METHOD TO DEVELOP HIGH OLEIC ACID SOYBEANS USING CONVENTIONAL SOYBEAN BREEDING TECHNIQUES

The Curators of the Unive...

6. A soybean plant comprising a first polynucleotide sequence encoding a mutant FAD2-1A and a second polynucleotide sequence
encoding a mutant FAD2-1B, wherein
said first polynucleotide sequence comprises a single base deletion of adenine (A) at position 543 or 544 of SEQ ID NO: 9,
and

said second polynucleotide sequence is selected from the group consisting of (a) a polynucleotide sequence encoding a FAD2-1B
mutant which includes an amino acid substitution of proline to arginine at position 137 (P137R) of SEQ ID NO: 12 and (b) a
polynucleotide sequence encoding a FAD2-1B mutant which includes an amino acid substitution of isoleucine to threonine at
position 143 (I143T) of SEQ ID NO: 12,

wherein oil from seed of said soybean plant has about 65% to about 85% oleic acid content.

US Pat. No. 9,068,346

ACOUSTIC ATTENUATORS BASED ON POROUS NANOSTRUCTURED MATERIALS

The Board of Regents of t...

1. An acoustic attenuating composition, wherein the composition comprises primary particles and secondary particles, wherein
said secondary particles are composed of the primary particles and the secondary particles are embedded in a network of nanofibers
and the composition contains pores ranging in size from less than 10 nm to more than one micron in diameter and further wherein
the composition exhibits acoustic transmission loss ranging from 20 to 60 dB/cm thickness of the composition.
US Pat. No. 9,204,603

SOYBEAN VARIETY S05-11482

The Curators of the Unive...

1. A plant of soybean variety S05-11482, representative seed of said soybean variety S05-11482 having been deposited under
ATCC designation PTA-12337.

US Pat. No. 9,299,526

METHOD TO FABRICATE PORTABLE ELECTRON SOURCE BASED ON NITROGEN INCORPORATED ULTRANANOCRYSTALLINE DIAMOND (N-UNCD)

UChicago Argonne, LLC, C...

1. A field emitter array device comprising,
a wafer substrate;
an electrical insulator layer disposed on the wafer substrate;
a plurality of metal tabs for establishing an electrical circuit;
a flat panel emitter layer comprising ultrananocrystalline diamond; and
a two dimensional electron extraction grid disposed above the flat panel emitter layer, thereby forming a two dimensional
field emitter array device.

US Pat. No. 9,474,271

METHOD FOR ENHANCING AMIDOHYDROLASE ACTIVITY OF FATTY ACID AMIDE HYDROLASE

Research Foundation of th...

1. A method for enhancing amidohydrolase activity of fatty acid amide hydrolase in a plant, the method comprising administering
a phenoxyacyl-ethanolamide composition to a plant such that hydrolysis of N-acylethanolamines (NAEs) by fatty acid amide hydrolase
(FAAH) in the plant is enhanced relative to a substantially identical plant that has not been administered with the phenoxyacyl-ethanolamide
composition, wherein the phenoxyacyl-ethanolamide in the composition is represented by a structure:
wherein R is an aliphatic side chain with between twelve and twenty carbons.

US Pat. No. 9,550,846

FLEXIBLE TO RIGID NANOPOROUS POLYURETHANE-ACRYLATE (PUAC) TYPE MATERIALS FOR STRUCTURAL AND THERMAL INSULATION APPLICATIONS

The Curators of the Unive...

1. A nanoporous material comprising a polyurethane-acrylate polymer formed by the polymerization of a urethane-acrylate star
monomer of the formula (I):

in the presence of a polymerization catalyst at 60° C. for 2-4 h, to give a wet gel, followed by aging of the wet gel for
24 h at 60° C., washing five times with acetone for 8 h per wash, and drying with supercritical fluid CO2;

wherein the nitrogen atoms of the urethane moieties in the urethane-acrylate star monomer of the formula (I) are independently
attached to their respective aryl rings at the 2, 3, or 4-positions of the aryl rings;

wherein each of W, X, and Y independently represents a C1-C6 straight chain alkyl group or a C1-C6 branched alkyl group;

wherein each of R1-R9 is independently a hydrogen, a C1-C6 straight chain alkyl group, or a C1-C6 branched alkyl group; and,

wherein the material is an aerogel.

US Pat. No. 9,562,927

FORCE DETECTION FOR MICROSCOPY BASED ON DIRECT TIP TRAJECTORY OBSERVATION

The Curators of the Unive...

1. An apparatus comprising:
a scanning probe microscope, the scanning probe microscope having a moveable tip, and wherein the scanning probe microscope
is configured to move the tip in a tapping mode to cause tapping movement for the tip;

a position detector, the position detector configured to (1) directly detect the tapping tip, and (2) generate an output signal
indicative of a plurality of positions for the detected tip over time; and

a processor configured for operation in conjunction with the position detector, the processor configured to (1) process data
representative of the output signal from the position detector, (2) determine a plurality of positions for the tapping tip
over time in at least one dimension based on the processed data, (3) process the determined tip positions, and (4) compute
a force for the tapping tip in at least one dimension based on the processed tip positions over time.

US Pat. No. 9,883,576

LOW-POWER, COMPACT PIEZOELECTRIC PARTICLE EMISSION

The Curators of the Unive...

1. A low-power, compact piezoelectric neutron generator comprising:
a piezoelectric transformer crystal formed from a piezoelectric material having an input end and an output end;
an output electrode electrically connected to the output end;
a voltage source electrically connected to the input end to apply a first voltage to the crystal and create a second voltage
that is higher than the first voltage at the output end caused by the piezoelectric effect, the second voltage creating an
electric field generally originating at the output electrode; an ion source configured to produce a plurality of ions, the
ions being accelerated as an ion beam by the electric field, the ion beam having an ion beam path; and,

an ion target electrically connected to the output electrode, the ion target being positioned in the ion beam path so that
the charged particles interact with the ion target to generate neutrons;

a vacuum chamber containing the piezoelectric transformer crystal, the ion source and the ion target.

US Pat. No. 9,507,367

METHOD AND SYSTEM FOR DYNAMIC STOCHASTIC OPTIMAL ELECTRIC POWER FLOW CONTROL

Clemson University, Clem...

1. An electrical power system comprising:
a dynamic stochastic optimal power flow (DSOPF) control system for receiving power flow commands and controlling an amount
of active and reactive power within an area controlled by said DSOPF control system;

a global scalable dynamic stochastic optimal power flow (S-DSOPF) controller configured to:
monitor one or more lines within the area;
determine global power flow commands based on the monitored lines and a global S-DSOPF model; and
communicate the global power flow commands to the DSOPF control system;
whereby said global S-DSOPF control system calculates said global S-DSOPF model representing an optimal power system state
for an electrical grid based upon condition data, and controls an amount of active and reactive power in said electrical grid;
and

whereby said DSOPF control system controls power flow within said area based on the global power flow commands and a DSOPF
model representing an optimal power system state for said area.

US Pat. No. 9,220,258

TISSUE PRESERVATION SYSTEM

The Curators of the Unive...

1. A process for osteochondral tissue preservation comprising storing the osteochondral tissue at room temperature in a container
comprising serum-free culture medium comprising dexamethasone for from at least 63 to 75 days prior to implantation, wherein
at least 70% of the cells of said osteochondral tissue remain viable after said storing compared to the viability of the cells
of the osteochondral tissue at day 0.
US Pat. No. 9,328,360

CONVERSION OF GLYCEROL TO 1,3-PROPANEDIOL UNDER HALOALKALINE CONDITIONS

The Curators of the Unive...

1. A method of producing 1,3-propanediol, said method comprising fermenting Halanaerobium hydrogeniformans with a source of glycerol in a fermentation reactor, whereby 1,3-propanediol is produced, said reactor comprising an inlet
for said source of glycerol, a fermentation chamber containing said H. hydrogeniformans in culture media, and an outlet for removing said 1,3-propanediol.

US Pat. No. 9,290,551

COMPOUNDS FOR TREATING PAPILLOMA VIRUS INFECTION

NanoVir LLC, Kalamazoo, ...

5. A method of treating HPV in a subject comprising administering to the subject an effective amount of a compound having
formula:
ImPP?PPI?PP?PP?PPP?PPP?Dp; ImPP?PPI?PP?PP?PPP?PPP?Ta; ImPP?PIP?PPI??P?PPP?PPP?Ta; ImPPP?PPP?PP?PPP?PPP?PPP?Dp; ImPPP?PPP?PP?PPP?PPP?PPP?Ta;
ImPP?PPI?PP?NH2PP?PPP?PPP?Ta; ImPP?PPI?PP?NH2PP?PPP?PPP?Dp; ImPP?PPI?PP?NH2PP?PPP?PPP?Dp; ImPP?PPI?PP?NH2PP?PPP?PPP?Ta; ImPP?PPI?PP?NHAcPP?PPP?PPP?Dp; ImPP?PPI?PP?PP?PPP?PPPPTa; or ImPP?PPP?PP?PPPPPTa;

or a pharmaceutically acceptable salt thereof;
wherein:
Im is desamino-imidazole;
P is 4-amino-2-carbonyl-N-methylpyrrole;
? is ?-alanine;
I is 4-amino-2-carbonyl-N-methylimidazole;
? is ?-amino butyric acid,
?NH2 is (R)-2,4-diaminobutyric acid reacted through either the 2-amino group or the 4-amino group;

?NHAc is (R)-2-(acetylamino)-4-aminobutyric acid;

Ta is 3,3?-diamino-N-methyldipropylamine; and
Dp is dimethylaminopropylamine.
US Pat. No. 9,119,769

METHOD FOR TRANSFORMING PHARMACEUTICAL CRYSTAL FORMS

The Curators of the Unive...

1. A method for transforming an organic solid from a first polymorphic form to a second polymorphic form, wherein the organic
solid is clarithromycin or lansoprazole, comprising the step of subjecting clarithromycin to a pressurized gas selected from
the group consisting of CO2 and N2 O or lansoprazole to a pressurized gas selected from the group consisting of CO2 N2 O and CH4 at less than 40 atm, at a temperature under 100° C. for a period of time, wherein said combinaton of pressure and temperature
is sufficient to cause a polymorphic transformation in said organic solid.

US Pat. No. 9,504,688

METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTION

THE REGENTS OF THE UNIVER...

8. A method of inhibiting the growth or biological activity of S. aureus and/or S. epidermidis, comprising contacting said S. aureus and/or S. epidermidis with a compound having the structure of Formula I, II, III or IV

Wherein X is S, NH, or O, R1 and R2 are, independently, selected from the group consisting of a C1-C8 alkyl, a C1-C8 alkenyl, and a C1-C8 cycloalkyl, wherein
said C1-C8 alkyl, a C1-C8 alkenyl, and a C1-C8 cycloalkyl are optionally substituted with F, CN, OR6, NR62, COR6, CO2R6, CONHR6, aryl or heteroaryl, wherein one or more alkyl carbons may be replaced by O;

R3 and R4 are independently H, a C1-C8 alkyl, or joined in a cycloalkyl ring of 3-7 carbons wherein at least one ring CH2 is replaced by O or N-G;

G is selected from the group consisting of H, C(?O)R6, SO2R6 and C(?O)OR6;

R5 is selected from the group consisting of H, C1-C6 alkyl, CN, OR6, NR62, COR6, CO2R6, CONHR6, aryl, heteroaryl, SO2R6, NHCOR6, SO2NHR6, and OCOR6;

R6 is selected from the group consisting of H, C1-C6 alkyl, C0-C3 alkyl-aryl, and C0-C3 alkyl-heteroaryl, all optionally substituted;

R7 and R8 are independently selected from the group consisting of H, C1-C6 alkyl, and joined in a cycloalkyl ring of 3-7 carbons, wherein
one of the ring CH2 groups may be replaced by O or N-G;

R9 is a C1-C5 alkyl;

R10 is a C2-C8 alkyl or alkenyl or cycloalkyl, optionally substituted with F, CN, OR6, NR62, CO2R6, CONHR6, aryl or heteroaryl, wherein one or more alkyl carbons may be replaced by O; and

R11 is H or a C1 alkyl,

wherein said compound inhibits the growth or biological activity of said S. aureus and/or S. epidermidis.

US Pat. No. 9,382,267

SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)

The Curators of the Unive...

1. A compound comprising Formula (I):
wherein,
B is a cluster boron;
X is an aromatic moiety having one or more nitrogen atoms;
n is an integer ranging from 1 and 6, and where n is greater than 1, the resulting hydrocarbyl chain may be saturated or unsaturated;
and

m is an integer ranging from 0 and 4, and where m is greater than 1, the resulting hydrocarbyl chain may be saturated or unsaturated.

US Pat. No. 9,333,232

METHODS FOR TREATING PAPILLOMA VIRUS INFECTION

NanoVir LLC, Kalamazoo, ...

21. A method of treating papilloma virus infected cells in a patient, the method comprising administering to a patient in
need thereof an effective amount of a compound selected from the group consisting of:
ImPP?PIP?PP?(NH2)PP?PPP?PPP?Ta;

ImPP?PPP?(NH2)PP?PPPP?Ta;

ImPPP?PP??PP?PPP?P?Ta;
ImPPP?PP??(NH2)PP?PPP?P?Ta;

ImPPP?PPP?PPP?PPP??Ta;
ImPP?PPP?PP?PPPP?Ta;
ImPPP?PP??(NH2)PP?PPP?P?Dp;

ImPPP?PP?PPP?(NH2)PPP?PPP?PPP?Dp; and

ImPPP?PP?PPP?PPP?PPP?PPP?Dp;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,173,693

APPARATUS AND METHOD FOR STERNAL CLOSURE

The Curators of the Unive...

1. A sternal closure fixation device, said device comprising:
a first sternum implant sized and structured to be disposed within an interior cavity of a cortical bone of a first half of
a severed sternum such that the first implant contacts at least opposing anterior and posterior faces of an interior wall
of the first half cortical bone of the severed sternum first half, the severed sternum first half having a first severance
face produced by severance of the sternum, the first implant comprising at least one pointed tine structured and operable
to at least one of contact and penetrate a costal margin face of the interior wall of the cortical bone of the first half
of the severed sternum when the first implant is disposed within the interior cavity of the first half of the severed sternum;

a second sternum implant sized and structured to be disposed within an interior cavity of a cortical bone of a second half
of the severed sternum, opposing the first implant, such that the second implant contacts at least opposing anterior and posterior
faces of an interior wall of the second half cortical bone of the severed sternum second half, the severed sternum second
half having a second severance face produced by severance of the sternum, the second implant comprising at least one pointed
tine structured and operable to at least one of contact and penetrate a costal margin face of the interior wall of the cortical
bone of the second half of the severed sternum when the second implant is disposed within the interior cavity of the second
half of the severed sternum; and

a cylindrical rigid fixation pin having a constant diameter along a length thereof that is sized and structured to be disposed
within an internal bore of the first implant and within an internal bore of the second implant, whereby when the first and
second halves of the severed sternum are joined to bring the first and second severance faces into contact with each other,
the first and second halves of the sternum are prevented from shear movement in any direction along a plane of the contacting
first and second severance faces, wherein the first and second implants each comprise at least two legs that define the respective
internal bore, and wherein each internal bore is tapered toward a distal end such that when the fixation pin is disposed within
the internal bores the legs of each respective implant will be forced radially outward such that each respective implant firmly
contacts the opposing faces of the interior wall of the respective cortical bone.

US Pat. No. 9,207,205

METHOD AND APPARATUS FOR CANCER SCREENING

The Curators of the Unive...

1. A method for screening for cancer in a mammal, the method comprising:
obtaining a biological sample from the mammal;
treating the biological sample with an oxidizing agent in a concentration sufficient such that at least about 90 wt % of concentration
of oncopterin (N2-(3-aminopropyl) biopterin) in the biological sample is in its fully oxidized state;

quantitatively measuring a concentration of oncopterin (N2-(3-aminopropyl) biopterin) in said biological sample by capillary
electrophoresis-lased induced fluorescence by subjecting the sample to capillary electrophoresis using laser-induced fluorescence
(CE-LIF) to cause the oxidized portion of said concentration of said oncopterin (N2-(3-aminopropyl) biopterin) to emit fluorescent
light, detecting the emitted fluorescence light, and analyzing the emitted fluorescence light to determine the concentration
of the oncopterin (N2-(3-aminopropyl) biopterin) in the biological sample; and

comparing the concentration of oncopterin (N2-(3-aminopropyl) biopterin) in the sample to an expected concentration of oncopterin
(N2-(3-aminopropyl) biopterin) for either a healthy or cancer-bearing mammal of the same species;

wherein the CE-LIF comprises directing laser light through a filter, a focal lens, and an iris of a first optical system and
into an electrophoresis capillary containing the biological sample to irradiate and cause fluorescence from the biological
sample; and receiving fluorescence emission from the biological sample through a second optical system comprising a confocal
lens having a magnification greater than 20× and an iris which focus emitted fluorescence onto a photomultiplier tube as a
light collection device for collecting fluorescent light emitted from the pteridine in the biological sample.

US Pat. No. 9,594,077

METHODS AND REAGENTS FOR EVALUATING THE BINDING OF MAMMALIAN SPERM

The Curators of the Unive...

1. A method of evaluating the ability of non-human mammalian sperm to bind to a mammalian egg, the method comprising:
(a) combining a sample of non-human mammalian sperm, a media that is conducive to maintaining the physiological activity of
the sperm, and at least one substrate that comprises bovine thyroglobulin on at least a portion of its surface, to allow for
at least a portion of the sample of non-human mammalian sperm to bind to the substrate, wherein the binding of sperm to the
substrate is indicative of the binding of sperm to a mammalian egg; and

(b) visualizing or quantitating the sperm bound to the substrate, thereby evaluating the ability of non-human mammalian sperm
to bind to a mammalian egg.

US Pat. No. 9,488,646

BIOMARKERS OF OSTEOARTHRITIS

The Curators of the Unive...

1. A method to detect osteoarthritis in a canine subject comprising:
(a) using a protein detection method to determine the levels of three or more different osteoarthritis marker polypeptides
in a synovial fluid sample collected from a first canine subject, wherein the three or more different osteoarthritis marker
polypeptides comprise MCP1, IL8, and KC;

(b) using the protein detection method to determine the levels of three or more different osteoarthritis marker polypeptides
in a biological fluid sample collected from a second canine control subject, wherein the three or more different osteoarthritis
marker polypeptides comprise MCP1, IL8, and KC;

(c) using the level of each of the three or more different osteoarthritis marker polypeptides in the first canine subject
and the second canine control subject to calculate a probability of the presence of osteoarthritis in the first canine subject,
and determining whether the probability is greater than or equal to at least about 80%; and

(d) when the probability from step (c) is greater than or equal to at least about 80%, determining that osteoarthritis is
present in the first canine subject.

US Pat. No. 9,204,606

SOYBEAN VARIETY S06-4649RR

The Curators of the Unive...

1. A plant of soybean variety S06-4649RR, representative seed of said soybean variety S06-4649RR having been deposited under
ATCC designation PTA-12641.

US Pat. No. 9,338,874

SYSTEMS AND METHODS TO GENERATE A SELF-CONFINED HIGH DESTINY AIR PLASMA

The Curators of the Unive...

14. An apparatus for generating a self-contained air plasma at an atmospheric pressure comprising:
a primary ignition region defined by a first shielding material positioned between an anode and a semi-permeable cathode,
the first shielding material having a first longitudinal cavity to contain a conductive wire extending between and in communication
with the anode and the cathode;

a primary high voltage circuit having at least one voltage source and at least one capacitor, the primary high voltage circuit
in communication with the anode and the cathode to apply a first high voltage pulse across the anode and cathode to cause
the wire to explode and generate an air plasma, wherein the first longitudinal cavity restricts radial expansion of the air
plasma;

a secondary ignition region defined by a second shielding material positioned between the cathode and a semi-permeable electrode,
the second shielding material having a second longitudinal cavity extending between the cathode and the electrode wherein
the second longitudinal cavity is in fluid communication with the first longitudinal cavity to receive the air plasma; and,

a secondary high voltage circuit having at least one other capacitor and in communication the voltage source, the secondary
high voltage circuit in further communication with the cathode and the electrode to apply a second high voltage pulse across
the gap between the cathode and the electrode wherein the second high voltage pulse heats and accelerates the air plasma as
it traverses the secondary ignition region and the electrode to form the self-contained air plasma at the atmospheric pressure.

US Pat. No. 9,132,175

BACILLUS BASED DELIVERY SYSTEM AND METHODS OF USE

The Curators of the Unive...

1. A method of reducing contaminants in an environment comprising distributing to a contaminated environment a recombinant
Bacillus cereus family member expressing a fusion construct, wherein the fusion construct comprises at least one molecule of interest
(MOI) and:
a) a targeting sequence consisting of a 16 amino acid sequence having at least about 43% identity with amino acids 20-35 of
SEQ ID NO. 7, wherein the identity with amino acids 25-35 is at least about 54%;

b) a targeting sequence consisting of amino acids 1-35 of SEQ ID NO. 7;
c) a targeting sequence consisting of amino acids 20-35 of SEQ ID NO. 7;
d) a targeting sequence comprising SEQ ID NO. 13;
e) a targeting sequence consisting of SEQ ID NO. 7;
f) a targeting sequence comprising amino acids 1-27 of SEQ ID NO. 8;
g) a targeting sequence comprising amino acids 12-27 of SEQ ID NO. 8;
h) a targeting sequence comprising SEQ ID NO. 8;
(i) an amino acid sequence comprising the amino acid sequence encoded by the entire open reading frame of BAS3290, wherein
BAS3290 comprises an N-terminal domain comprising SEQ ID NO: 8;

j) a targeting sequence comprising amino acids 1-38 of SEQ ID NO. 9;
k) a targeting sequence comprising amino acids 23-38 of SEQ ID NO. 9;
l) a targeting sequence comprising SEQ ID NO. 9; or
m) a targeting sequence comprising a methionine residue covalently bound to an amino acid sequence consisting of 16 amino
acids having at least 43% identity with amino acids 20-35 of SEQ ID NO.7, wherein the identity with amino acids 25-35 is at
least 54%;
wherein the MOI is physically attached to the exosporium of the recombinant Bacillus cereus family member.

US Pat. No. 9,404,027

METHOD OF PRODUCING LOWER ALCOHOLS FROM GLYCEROL

The Curators of the Unive...

1. A process for producing antifreeze from a crude glycerol byproduct of either a C1 to C4 alkyl alcohol alcoholysis of a glyceride or hydrolysis of a glyceride, the process comprising:
neutralizing the crude glycerol byproduct to achieve a pH between 5 and 12 to form a neutralized crude glycerol byproduct;
separating C1 to C4 alcohol and water from the neutralized crude glycerol byproduct such that the combined concentrations of water and C1 to C4 alcohols is less than about 5 (wt) %, thereby forming a separated crude glycerol byproduct; and

contacting the separated crude glycerol byproduct with a hydrogenation catalyst and hydrogen at a pressure of between about
0.1 and 200 bar and at a temperature between about 100° C. and 290° C. for a period of time sufficient to achieve a conversion
of glycerol of between 60 and 90% to form the antifreeze, which comprises, on a water-free basis, from about 0.5% to about
60% glycerol and from about 20% to about 85% propylene glycol.

US Pat. No. 9,195,891

METHOD OF PREDICTING CROP YIELD LOSS DUE TO N-DEFICIENCY

The Curators of the Unive...

1. A method for determining a crop yield loss due to nitrogen deficiency in at least one or more crop fields based on an analysis
of at least one or more remote sensing images, the method comprising:
a. obtaining the one or more remote sensing images of the at least one or more crop fields;
b. assigning spatial coordinates to the at least one or more remote sensing images, represented by pixels or polygons comprised
of aggregated pixels, from the at least one or more remote sensing images;

c. establishing a reference color value for a reflectivity of a color for the at least one or more remote sensing images,
wherein the color is selected from red, blue, green, and infrared;

d. calculating a relative color value of each pixel in the at least one or more remote sensing images by dividing a color
value of each pixel by the reference color value;

e. estimating a yield loss (YL) of each pixel by substituting the relative color value (RC) of each pixel into the formula
YL=C1×RC?C2, wherein C1 and C2 are empirically derived constants; and,

f. constructing a yield loss map from a spatially referenced yield loss of each pixel; wherein the yield loss comprises a
decrease in crop yield per acre of a crop.

US Pat. No. 9,133,228

GUANIDINYL-SUBSTITUTED POLYAMIDES USEFUL FOR TREATING HUMAN PAPILLOMA VIRUS

NanoVir LLC, Kalamazoo, ...

1. A compound of the formula:
G-(X)n-?q-(X)m-A

or a pharmaceutically acceptable salt thereof, wherein
m is 5-12;
n is 4-10;
G is a guanidinyl radical is the formula

or its tautomer, wherein R1, R2, R3, or R4 is H, alkyl, aryl or aralkyl;

each X is independently selected from 4-amino-2-carbonyl-N-methylimidazole (Im), 4-amino-2-carbonyl-N-methylpyrrole (Py) or
?-alanine (?);

?q is ?-aminobutyric acid (?), 2,4-diaminobutyric acid (?NH2), or H2N(CH2)2CH(NHC(?O)NHR)CO2H, wherein R is —(CH2)3—N(CH3)—(CH2)3—NH2 (?NHR?) or —(CH2)3—N(CH3)2 (?NHR?); and

A is 3,3?-diamino-N-methyldipropylamine (Ta) or 3-(dimethylamino)propylamine (Dp).
US Pat. No. 10,231,383

NEMATODE RESISTANT CROPS

The Curators of the Unive...

1. A method for inhibiting plant parasitic nematode damage to a potato plant, said method comprising:(1) reducing the expression of an endogenous CLAVATA2-like (CLV2-like) gene by introducing into said potato plant one or more non-natural mutations in said CLV2-like gene, or by expressing in said potato plant RNAi to silence said CLV2-like gene, wherein said CLV2-like gene is set forth in SEQ ID NO: 11, and
(2) growing said potato plant comprising said one or more non-natural mutations or expressing said RNAi, thereby inhibiting plant parasitic nematode damage to said potato plant.

US Pat. No. 9,486,554

WOUND CARE COMPOSITIONS COMPRISING BORATE (B2O3) GLASS-BASED PARTICLES

The Curators of the Unive...

1. Glass-based particles of a biocompatible material intermixed into a carrier for angiogenesis in wound-care management,
wherein the glass-based particles comprise from 40 to about 80 wt % borate (B2O3);

wherein the carrier is a biocompatible ointment or cream or a surgical glue for closing a wound; and
wherein the glass-based particles are angiogenic.

US Pat. No. 9,482,626

WAVEGUIDE PROBE FOR NONDESTRUCTIVE MATERIAL CHARACTERIZATION

The Curators of the Unive...

1. An open-ended waveguide apparatus comprising:
a hollow guide structure and a signal source coupled thereto, said guide structure further having an open end defining an
aperture through which an electromagnetic signal generated by the signal source is transmitted to an object located remotely
from the aperture and through which an electromagnetic field reflected from the object is received by the aperture; and

a flange extending outwardly from the guide structure at the aperture, said flange having one or more continuously curved
edge margins shaped to reduce undesired electromagnetic scattering from one or more edges of the flange and received by the
aperture, wherein the guide structure is adapted for coupling to a receiver for sampling the reflected electromagnetic field
received by the aperture, and wherein the receiver is adapted for coupling to a processor for determining at least one material
characteristic of the object based on a sampled electromagnetic field reflected from the object.

US Pat. No. 9,176,281

CAPILLARY WALL COUPLED WHISPERING GALLERY MODE MICRORESONATOR

The Curators of the Unive...

1. A microresonator structure comprising:
a waveguide of elongated cylindrical shape including a first section of optical transmission material and a cavity section
axially aligned with the first section, the cavity section including a first hollow cavity adjacent to the first section including
a first sidewall of optical transmission material with an inner surface that tapers inward to an apex positioned adjacent
to the first section and a second hollow cavity positioned adjacent to the first cavity of cylindrical shape including a circumferential
second sidewall of optical transmission material that abuts the first sidewall; and

a microsphere with a spherical outer surface, the microsphere positioned within the cavity section such that the outer surface
contacts a portion of the first sidewall and a portion of the second sidewall,

wherein a portion of light coupled into the first section of the waveguide is coupled into the microsphere where the microsphere
contacts the waveguide.

US Pat. No. 9,107,385

ANIMAL KENNEL FOR SCIENTIFIC EXAMINATION

The Curators of the Unive...

1. An animal kennel comprising front, rear, top, bottom, and opposite side walls that collectively define a cavity, at least
a portion of the cavity having a horizontal cross-section that is bordered by the front, rear, and opposite side walls, the
cross-section being generally trapezoidal in shape and having a front portion and a rear portion, the front portion being
narrower between the opposite side walls than the rear portion, a majority of each of the front, rear, top, bottom and opposite
side walls being formed of a material that is translucent and radiolucent, the rear wall extending the width between the sidewalls
at the rear portion of the cross-section and the height between the top and bottom walls, the entire rear wall being hinged
to one of the side walls such that the rear wall is configured to selectively create an opening that permits access into the
cavity from an environment exterior to the kennel.

US Pat. No. 9,050,035

DEVICE TO MEASURE PUPILLARY LIGHT REFLEX IN INFANTS AND TODDLERS

The Curators of the Unive...

1. A pupillary light reflex system, said system comprising:
a remote tracking and imaging system that is structured and operable to generate and acquire high resolution pupil stimulus
and response data from a test subject while the test subject is moving and is disposed a distance from the remote tracking
and imaging system that is at least one-third of a meter, wherein the remote tracking and imaging system comprises:

a subject movement tracking camera structured and operable to acquire subject eye location data regarding movement of a location
of the subject's eyes within a field of view of the subject movement tracking camera;

an optical stimulation device structured and operable to generate light that causes a pupillary response of the test subject's
eyes;

at least one pupil data acquisition camera structured and operable to acquire the high-resolution pupillary stimulus and response
data;

a scanning lens structured and operable direct a line-of-sight of each pupil data acquisition camera(s) toward the test subject's
pupils;

a translational stage connected to the scanning lens and structured and operable to continuously linearly adjust a position
of the scanning lens along a length of the translational stage to maintain an on-axis line-of-sight of the pupil data acquisition
camera(s) with subject's pupils as the subject moves his/her head; and

a computer based system controller that is structure and operable to execute pupillary light reflex (PLR) software to control
the operation of the remote tracking and imaging system and compute PLR information based on the pupil stimulus and response
data acquired as the test subject is moving.

US Pat. No. 9,519,885

SYSTEM AND METHOD FOR LINKING A WEB-BASED RESOURCE WITH AN ELECTRONIC MEDICAL RECORD

The Curators of the Unive...

1. A data processing system comprising:
an electronic medical record (“EMR”) system through which solely health care providers can edit and store information in an
EMR of a patient, wherein the EMR system is configured to construct a message that is associated with the patient's EMR accessible
solely by health care providers, wherein the message includes: (i) a path to a web-based resource and (ii) medical data indicative
of a medical condition of the patient that is derived from the patient's EMR, the EMR system configured to store a hyperlink
to the web-based resource within the patient's EMR; and

a web server configured to
identify the web-based resource responsive to the message, wherein the web server is configured to modify the identified web-based
resource based on the medical data provided in the message, and

present the modified web-based resource in response to selection of the hyperlink.
US Pat. No. 9,422,545

LIPOPOLYSACCHARIDE-TARGETED PEPTIDE MIMIC VACCINE AGAINST Q FEVER

The Curators of the Unive...

1. A lipopolysaccharide-based peptide mimetic for protection against infection of gram negative intracellular bacteria in
a subject; wherein the lipopolysaccharide-based peptide mimetic sequence comprises a sequence of SLTWHKHELHRK (SEQ ID NO:
7) or SPPWHKHELHRK (SEQ ID NO: 8), or a peptide sequence having at least 90% identity to SLTWHKHELHRK (SEQ ID NO: 7) or SPPWHKHELHRK
(SEQ ID NO: 8), or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,397,345

CATHODES FOR LITHIUM-AIR BATTERY CELLS WITH ACID ELECTROLYTES

The Curators of the Unive...

1. A layered metal-air cathode for a metal-air battery, said cathode comprising three layers laminated together, the three
layers comprising:
an active catalyst layer;
a transition layer laminated to the active catalyst layer, the transition layer comprises carbon nanofibers; and
a backing layer laminated to the transition layer such that the transition layer is disposed between the active catalyst layer
and the backing layer.

US Pat. No. 9,371,541

GENES IMPLICATED IN RESISTANCE TO SOYBEAN CYST NEMATODE INFECTION AND METHODS OF THEIR USE

The Curators of the Unive...

1. A transgenic soybean plant generated from a host soybean plant, said transgenic soybean plant comprising a construct comprising
a nucleic acid encoding SEQ ID NO:166 operably linked to a heterologous promoter, wherein said transgenic soybean plant has
an increased expression level of said protein compared to the host soybean plant and is more resistant to nematode infection
when compared to the host soybean plant.
US Pat. No. 9,242,016

GOLD COATED LANTHANIDE NANOPARTICLES

The Curators of the Unive...

1. An ?-particle emitting nanoparticle comprising:
(a) an ?-particle emitting core that comprises an ?-emitting-radioisotope-doped LnPO4; and

(b) a sequestration shell enclosing the core that comprises LnPO4 and is free of an ?-emitting-radioisotope and that allows at least some of the ? emissions from the ?-emitting radioisotope
to pass therethrough and reduces the release of radioactive decay products of the ?-emitting radioisotope from the ?-particle
emitting nanoparticle compared to an otherwise equivalent ?-particle emitting nanoparticle comprising the same ?-particle
emitting core but not comprising the sequestration shell enclosing the core; and

wherein Ln of the ?-particle emitting core and the sequestration shell are separately selectable lanthanide elements from
the group consisting of La, Gd, Sm, Eu, Tb, Dy, Ho, Lu, Nd, Pm, and combinations thereof, and the ?-particle emitting radioisotope
is selected from the group consisting of 225AC, 223Ra, any radioactive decay products thereof, and combinations thereof, wherein the radioactive decay products of 225AC are selected from the group consisting of 221Fr, 217At, 213Bi, 213Po, 209Tl, 209Pb, and combinations thereof, and wherein the radioactive decay products of 223Ra are selected from the group consisting of 219Rn, 215Po, 211Pb, 211Bi, 207Tl, and combinations thereof.

US Pat. No. 9,061,054

ERBB-2 RECEPTOR TARGETING PEPTIDE

The Curators of The Unive...

1. A method for diagnosing ErbB-2-positive cancer in a subject comprising:
(a) administering to said subject a peptide-diagnostic agent complex, wherein said peptide is between 6 and about 100 residues
in length and comprises the sequence KCCYSL (SEQ ID NO: 1) and wherein the peptide binds to ErbB-2; and

(b) assessing the amount and/or localization in said subject, of the diagnostic agent.

US Pat. No. 9,508,007

METHOD OF PREDICTING CROP YIELD LOSS DUE TO N-DEFICIENCY

The Curators of the Unive...

1. A method for determining a crop yield loss due to nitrogen deficiency in at least one or more crop fields based on an analysis
of at least one or more remote sensing images, the method comprising:
a. obtaining the one or more remote sensing images of the at least one or more crop fields;
b. assigning spatial coordinates to the at least one or more remote sensing images, represented by pixels or polygons comprised
of aggregated pixels, from the at least one or more remote sensing images;

c. calculating a combination index value comprising at least two wavelengths at each pixel;
d. selecting a reference index value from the combination index values;
e. calculating a relative index value of each pixel in the at least one or more remote sensing images by dividing the combination
index value by the reference index value;

f. estimating a yield loss of each pixel from a function of the relative index values; and,
g. constructing a yield loss map from a spatially referenced yield loss of each pixel;
wherein the yield loss comprises a decrease in crop yield per acre of a crop.

US Pat. No. 9,481,036

METHOD FOR FABRICATING BIOCOMPATIBLE POROUS TITANIUM

The Curators of the Unive...

1. A method for fabricating biocompatible porous metals, the method comprising:
mixing a metal powder and a salt to form a mixture;
compacting the mixture in a die under pressure to form a construct comprising a predetermined shape; and
sintering the construct in a molten sodium chloride bath to produce a sintered construct.
US Pat. No. 9,358,310

EGCG STABILIZED GOLD NANOPARTICLES AND METHOD FOR MAKING SAME

The Curators of the Unive...

1. An environmentally friendly method for making epigallocatechin Gallate (EGCg) stabilized gold nanoparticles, the method
comprising:
mixing a solution of epigallocatechin Gallate (EGCg) as a reducing agent with an aqueous solution containing gold salts;
permitting reaction of the gold salts, in the absence of any other reducing agent, to form stabilized, biocompatible gold
nanoparticles.

US Pat. No. 9,456,890

SCAFFOLD FOR BONE AND TISSUE REPAIR IN MAMMALS

The Curators of the Unive...

1. A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, the scaffold comprising:
a rigid scaffold body having a scaffold central axis, a scaffold transverse dimension, and a scaffold lengthwise dimension
which is greater than the scaffold transverse dimension, the scaffold body having a compressive strength between about 20
and about 250 MPa and comprising:

biocompatible inorganic glass fibers each having a fiber transverse dimension and a fiber lengthwise dimension which is at
least about 10 times the fiber transverse dimension; and

wherein each of the fibers has a diameter between about 20 and about 5000 microns;
wherein at least about 75 vol % of the fibers are longitudinally co-aligned and lie generally lengthwise of the scaffold central
axis, are generally free of helical orientation about the scaffold central axis, and are arranged to define open channels
within the scaffold which allow fluid flow into and lengthwise within the scaffold; and

wherein adjacent longitudinally co-aligned fibers are bonded together.

US Pat. No. 9,046,605

THREE-DIMENSIONAL HOLOGRAPHICAL IMAGING

The Curators of the Unive...

1. A holographic imaging system comprising:
an antenna having a transmission line coupled thereto, said transmission line coupled to the antenna at one end and coupled
to a signal source at another end, said antenna defining an aperture through which a signal generated by the signal source
is transmitted incident to an object located remotely from the aperture and through which a signal reflected from the object
is received by the antenna aperture;

a standing wave probe located at a distance from the antenna aperture, wherein the distance of the standing wave probe from
the antenna aperture is a fraction of a wavelength of the signal generated by the signal source such that the standing wave
probe is phase-referenced to the antenna aperture for sampling the reflected signal;

a detector connected to the standing wave probe and configured to receive the sampled reflected signal, the detector providing
an output signal that represents a real-valued signal proportional to an in-phase component of the reflected signal from the
object and determining a reflection coefficient from the remote object measured at the aperture of the antenna; and

a processor configured to execute an imaging algorithm for generating a multi-dimensional profile representative of the object
based on the output signal from the detector.

US Pat. No. 9,488,637

COMBINATION OF SINGLE-CELL ELECTROPORATION AND ELECTRICAL RECORDING USING THE SAME ELECTRODE

THE CURATORS OF THE UNIVE...

1. A method for stimulating and measuring exocytosis from a cell, comprising:
applying at least one voltage pulse to a cell that is in the presence of an exogenous inorganic anion and in the absence of
exogenous free calcium ions through an electrode on a device to provide a voltage gradient in solution surrounding the cell,
said cell residing in a drop of solution such that said cell is adjacent to said electrode, said solution drop comprising
said exogenous inorganic anion, prepared without addition of a calcium ion source compound, and being confined to a part on
the device where the electrode is located such that said solution drop is sitting on a surface of said electrode, the applied
voltage and concentration of said inorganic anion being sufficient to cause a stimulation of said cell; and,

recording, through said same electrode while the cell remains adjacent to the electrode, a current signal indicative of a
release of an electrochemically active substance from said stimulated cell.

US Pat. No. 9,308,987

DRAG REDUCTION UTILIZING DRIVEN MICRO-CAVITIES

The Curators of the Unive...

1. A high-speed vehicle or device comprising:
a surface configured to move through a fluid such that the fluid flows across the surface in a primary flow direction, the
fluid flow across the surface defining a velocity gradient ranging from a first velocity adjacent the surface to a free stream
velocity at a position spaced a first distance from the surface in an outward direction that is at least substantially perpendicular
to the primary flow direction, with the fluid flow thereby defining a boundary layer having a boundary layer thickness at
least substantially equal to the first distance;

a subsurface spaced from the surface in an inward direction, the inward direction being at least substantially opposite the
outward direction; and

a plurality of cavity-defining structures projecting generally in the outward direction relative to the subsurface and extending
generally transverse to the primary flow direction,

said cavity-defining structures being spaced apart in the primary flow direction,
each of said cavity-defining structures presenting a generally upstream face, a generally downstream face, and a midpoint
spaced between the upstream face and the downstream face,

each adjacent pair of said cavity-defining structures and said subsurface at least in part cooperatively defining a cavity
therebetween,

each of said cavities presenting a cavity depth defined as a distance in the inward direction between the surface and the
subsurface,

each of said cavities presenting a cavity length defined as a distance between the midpoints of a corresponding pair of the
cavity-defining structures,

each of said cavity-defining structures at least in part defining at least one interconnecting channel extending between adjacent
ones of the cavities to fluidly interconnect said cavities.

US Pat. No. 9,139,456

CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS

The Curators of the Unive...

1. A compound of the formula:

wherein R1=hydrogen, sulfonamide, carbamoyl, carboxamide or benzyl, R2=hydrogen, methyl, ethyl, n-propyl, isopropyl or alkyl

and R3=


wherein x, y, and z vary independently from 1 to 4, X=CH2 and O, and R4=hydrogen, methyl, ethyl, n-propyl, isopropyl or alkyl;


wherein x, y, and z vary independently from 1 to 4, and R4=hydrogen, methyl, ethyl, n-propyl, isopropyl or alkyl;


wherein x and y vary independently from 1 to 4, X=CH2 and O, and R4=hydrogen, methyl, ethyl, n-propyl, isopropyl or alkyl;


wherein x and y vary independently from 1 to 4, X=CH2 and O, and R4=hydrogen, methyl, ethyl, n-propyl, isopropyl or alkyl;


wherein x varies from 1-4, y varies from 1-2, and z varies independently from 2 to 8, R4=hydrogen, methyl, ethyl, n-propyl, isopropyl or similar alkyl substituent, and R5=hydrogen, methyl, ethyl, n-propyl, isopropyl or alkyl; or


wherein x varies from 1-4, y varies from 1-2, and z varies independently from 2 to 8, R5=hydrogen, methyl, ethyl, n-propyl, isopropyl or similar alkyl substituent, and R6=hydrogen, methyl, ethyl, n-propyl, isopropyl or alkyl, or Ph or aryl.

US Pat. No. 9,045,746

NANOSTRUCTURED CARBON BASED BIOCATALYST FOR REMEDIATION OF ENVIRONMENTAL POLLUTANTS

The Curators of the Unive...

1. A method of reducing pollutants and/or toxins in an environment comprising the steps of introducing to a contaminated environment
an amide-functionalized ordered mesoporous carbon conjugated with a biotin conjugate and at least one toxin-degrading enzyme.

US Pat. No. 9,217,002

CLUSTER BORON COMPOUNDS AND USES THEREOF

The Curators of the Unive...

1. A method of treating a condition associated with sodium channel function in a subject in need of treatment, the method
comprising administering to the subject a carborane substituted lidocaine or carborane substituted lidocaine derivative comprising
Formulae (I)(b)-(g), (II), or (Ill):

wherein
B is a carborane;
R1 represents hydrocarbyl or substituted hydrocarbyl;

R2 and R3 are independently chosen from hydrocarbyl and substituted hydrocarbyl;

and R1, R2 and R3 may form one or more rings.

US Pat. No. 9,329,223

DEEP LEVEL TRANSIENT SPECTROMETER

The Curators of the Unive...

1. A method for detecting surface and bulk deep states in semiconductor materials, said method comprising:
setting a switch of a switching device of a detection circuit of charge based deep level transient spectrometer to one of
a closed position to configure the detection circuit in a parallel mode, wherein the the detection circuit is configured to
test a first type of semiconductor material, and an open position to configure the detection circuit in a series mode, wherein
the the detection circuit is configured to test a first type of semiconductor material,

inputting, via a user interface of the detection circuit user defined inputs, the user defined inputs comprising:
a charging time during which traps of a device under test will be excited;
a delay time during which integration of charge outputs from the device under test will wait to avoid the integration of switching
transients;

a read period for defining a duration of a single cycle for the excitation of the traps and a discharge of the charge output
of the device under test;

a number of sample array averages defining a number of iterations that a sample amplitude array parameter is averaged to increase
the signal-to-noise ratio;

a sampling rate defining a number of samples per unit time taken from a voltage charge output signal which are used to populate
an amplitude and time array; and

a number of samples points defining a size of the amplitude and time array;
inputting to the device under test, via a data acquition module of the detection circuit, excitation voltage pulses based
on the input user defined inputs and the switch setting, and via execution of an analog-to-digital conversion and timing program
by a control system of the charge based deep level transient spectrometer;

sampling, via the data acquistion module, digitized voltage charge outputs of the device under test generated in response
to the input excitation voltage pulses, based on the user inputs and via execution of the analog-to-digital conversion and
timing program by the control system; and

obtaining at least one of a trap density, a trap emission rate, and a trap activation energy for deep level transients of
the device under test based on the digitized voltage charge outputs via execution of a Q-DLTS data analysis program by the
control system.

US Pat. No. 9,051,581

DEFENSE PEPTIDES AGAINST FUNGAL INFECTION AND METHOD OF THEIR USE

The Curators of the Unive...

15. A method for conferring fungal resistance upon a host plant, said host plant being susceptible to fungal infection, said
method comprising:
(a) introducing into said host plant a polynucleotide to obtain a transgenic plant, said polynucleotide comprising a first
DNA fragment encoding a first polypeptide comprising SEQ ID NO: 1 and a second DNA fragment encoding a second polypeptide
facilitating the presentment of said first polypeptide to a pathogen, wherein said second polypeptide is a cytokinin oxidase
(CKX) or a coat protein of M13 phage; and

(b) allowing said first and second polypeptides to be expressed in said transgenic plant, wherein said transgenic plant is
more resistant than said host plant to fungal infection.

US Pat. No. 9,752,116

SELF-ASSEMBLING CELL AGGREGATES AND METHODS OF MAKING ENGINEERED TISSUE USING THE SAME

The Curators of the Unive...

1. A method of producing a tissue construct, comprising depositing cell aggregates from a dispensing device, and allowing
the cell aggregates to fuse.

US Pat. No. 9,314,157

DEVICE TO MEASURE PUPILLARY LIGHT REFLEX IN INFANTS AND TODDLERS

The Curators of the Unive...

1. A pupillary light reflex system, said system comprising:
a remote tracking and imaging system that is structured and operable to generate and acquire high resolution pupil stimulus
and response data from a test subject while the test subject's head is moving and the test subject is disposed a distance
from the remote tracking and imaging system that is at least one-third of a meter, wherein the remote tracking and imaging
system comprises:

a subject movement tracking camera structured and operable to continuously track 3-dimensional and rotational movement of
the test subject's head within a field of view of the subject movement tracking camera to acquire subject eye location data
regarding movement of a location of the subject's eyes within a field of view of the subject movement tracking camera;

an optical stimulation device structured and operable to generate light that causes a pupillary response of the test subject's
eyes; and

at least one pupil data acquisition camera structured and operable to acquire the high-resolution pupillary stimulus and response
data; and

a computer based system controller that is structure and operable to execute pupillary light reflex (PLR) software to control
the operation of the remote tracking and imaging system and compute PLR information based on the pupil stimulus and response
data acquired as the test subject is moving, and to correct a measured pupil size based on the subject's head position, orientation
and eye gaze direction.

US Pat. No. 9,081,045

HIGH FREQUENCY ANALYSIS OF A DEVICE UNDER TEST

The Curators of the Unive...

1. A phase shifter comprising a waveguide coupled to a transmission line, said transmission line having a standing wave thereon,
said standing wave being at a frequency greater than very high frequency and comprising a coherent addition of a signal incident
to a device under test and a signal reflected from the device under test, said waveguide having a plurality of slots formed
therein, said slots configured to minimally disturb the standing wave and each having dimensions that are sub-resonant with
respect to a wavelength of the standing wave on the transmission line, and said slots each having a controllable active element
corresponding thereto for selectively loading the slots to apply a plurality of phase shifts to the standing wave.

US Pat. No. 9,696,275

ADDRESSABLE ELECTRODE ARRAYS IN MULTIPLE FLUIDIC COMPARTMENTS AND USES THEREOF

The Curators of the Unive...

1. A method for measuring a signal corresponding to a characteristic of a fluid using an electrode array, the electrode array
comprising (1) a first working electrode, wherein the first working electrode is located in a first compartment that contains
the fluid and is in contact with the fluid, (2) a first reference electrode, wherein the first reference electrode is located
in the first compartment and is in contact with the fluid but not the first working electrode, (3) a second working electrode,
wherein the second working electrode is located in a second compartment that contains the fluid and is in contact with the
fluid, and (4) a second reference electrode, wherein the second reference electrode is located in the second compartment and
is in contact with the fluid but not the second working electrode, the method comprising:
enabling the first working electrode of the electrode array by controlling a first voltage potential relationship between
the enabled first working electrode and the first reference electrode,

while the first working electrode is enabled, disabling the second working electrode of the electrode array by controlling
a second voltage potential relationship between the disabled second working electrode and the second reference electrode;
and

measuring a signal produced by the enabled first working electrode while the second working electrode is disabled, the measured
signal corresponding to a characteristic of the fluid in the first compartment.

US Pat. No. 9,556,415

SELF-ASSEMBLING MULTICELLULAR BODIES AND METHODS OF PRODUCING A THREE-DIMENSIONAL BIOLOGICAL STRUCTURE USING THE SAME

The Curators of the Unive...

1. A method of producing a three-dimensional biological engineered tissue, the method comprising:
arranging a plurality of elongate multicellular bodies on a substrate according to a pattern such that each of the multicellular
bodies contacts at least one other multicellular body, wherein each multicellular body comprises a plurality of living cells,

arranging one or more filler bodies in the pattern with the multicellular bodies so that each filler body contacts at least
one multicellular body or another filler body, each filler body comprising a biocompatible material that resists migration
and ingrowth of cells from the multicellular bodies into the filler bodies and resists adherence of cells in the multicellular
bodies to the filler bodies,

allowing at least one of the multicellular bodies to fuse with at least one other multicellular body to produce a three-dimensional
biological engineered tissue; and

removing the one or more filler bodies.
US Pat. No. 10,070,614

SOYBEAN RESISTANT TO CYST NEMATODES

BOARD OF TRUSTEES OF SOUT...

1. A plant of an agronomically elite soybean variety with soybean cyst nematode (SCN) resistance, comprising an GmSHMT allele containing mutations P130R and N358Y operably linked to a promoter, wherein the promoter comprises a sequence comprises the entire length of SEQ ID NO: 4 having the nucleic acid substitutions C1080T and C2244T and the nucleic acid deletion ?2069A, or a functional fragment thereof, wherein the functional fragment comprises the nucleic acid substitutions C1080T and C2244T and the nucleic acid deletion ?2069A.

US Pat. No. 9,181,571

REUSABLE PCR AMPLIFICATION SYSTEM AND METHOD

The Curators of the Unive...

1. A method for amplifying a DNA sample on an amplification chip for DNA amplification, the method comprising:
providing the DNA sample having a concentration of 1 picogram per microliter or less;
denaturing the DNA sample on the amplification chip, wherein the inner surfaces of the amplification chip consist of a polydimethylsiloxane
layer bonded to a spin-on glass layer;

associating the DNA sample with primers on the amplification chip; and
amplifying the DNA sample on the amplification chip.

US Pat. No. 9,408,561

ACTIVITY ANALYSIS, FALL DETECTION AND RISK ASSESSMENT SYSTEMS AND METHODS

The Curators of the Unive...

1. A method comprising:
receiving, by at least one processor, depth image data from at least one depth camera, wherein the depth image data comprises
a plurality of frames that depict a person walking through a home environment over time, the frames comprising a plurality
of pixels;

performing, by the at least one processor, segmentation on the pixels of the frames;
in response to the segmentation, (1) generating, by the at least one processor, a three-dimensional (3D) data object based
on the depth image data, and (2) tracking, by the at least one processor, the 3D data object over a plurality of frames of
the depth image data, wherein the tracked 3D data object comprises time-indexed spatial data that represents the person walking
through the home environment over time;

identifying, by the at least one processor, a walking sequence from the tracked 3D data object, wherein the identifying step
comprises:

the at least one processor determining a speed for the tracked 3D data object over a time frame;
the at least one processor comparing the determined speed with a speed threshold;
in response to the comparison indicating that the determined speed is greater than the speed threshold, the at least one processor
assigning a state indicative of walking to the tracked 3D data object;

while the tracked 3D data object is in the assigned walking state:
the at least one processor determining a walk straightness for the tracked 3D data object;
the at least one processor determining a walk length for the tracked 3D data object;
the at least one processor determining a walk duration for the tracked 3D data object;
the at least one processor saving the tracked 3D data object in memory as the identified walking sequence when (i) the determined
walk straightness exceeds a straightness threshold, (ii) the determined walk length exceeds a walk length threshold, and (iii)
the determined walk duration exceed a walk duration threshold;

the at least one processor excluding from the identified walking sequence in the memory the time-indexed spatial data from
the tracked 3D data object corresponding to a time period where the determined walk straightness is less than the walk straightness
threshold;

the at least one processor repeating the speed determining step and the comparing step for the tracked 3D data object while
the tracked 3D data object is in the assigned walking state; and

the at least one processor assigning a state indicative of not walking to the tracked 3D data object in response to a determination
that the speed of the tracked 3D data object in the walking state has fallen below the speed threshold;

analyzing, by the at least one processor, the time-indexed spatial data from the identified walking sequence to generate one
or more gait parameters; and

performing, by the at least one processor, at least one health risk assessment based on the one or more gait parameters to
determine a health risk assessment score for the person.

US Pat. No. 9,351,966

COMPOSITION COMPRISING A COMBINATION OF OMEPRAZOLE AND LANSOPRAZOLE, AND A BUFFERING AGENT, AND METHODS OF USING SAME

The Curators of the Unive...

1. A method of inhibiting gastric acid secretion comprising administering to a subject in need thereof a pharmaceutical composition
comprising omeprazole in an amount of about 40 mg to about 120 mg, lansoprazole in an amount of about 40 mg to about 120 mg
wherein the ratio of omeprazole to lansoprazole is 1:1, and at least one buffering agent in an amount of about 100 mg to about
4000 mg.

US Pat. No. 9,561,303

CONTROLLING CALCIUM COMPOUND FORMATION IN BIOCOMPATIBLE MATERIALS FOR TISSUE REGENERATION AND REPAIR IN MAMMALS

The Curators of the Unive...

1. A biocompatible composition for tissue repair or regeneration in mammals comprising:
40 to 80 wt % B2O3;

2.5 to 50 wt % CaO;
one or more of MgO, SrO, and combinations thereof in a cumulative concentration of 5 to 40 wt %;
one or more of Li2O, Na2O, K2O, Rb2O and combinations thereof;

one or more director elements selected from the group consisting of Cu, Zn, Fe, Mn, Ba, Co, S, V, and/or Y in a cumulative
concentration between 0.05 and 5 wt % to promote in vivo calcium compound formation of calcium carbonate or other calcium-containing
materials other than hydroxyapatite;

wherein upon direct application of the biocompatible composition to a mammalian host, calcium carbonate or other calcium-containing
materials other than hydroxyapatite form upon bioreaction of the composition with bodily fluids;

wherein the composition is in a form of one or more of fibers, hollow fibers, tubes, ribbons, solid spheres, hollow spheres,
particles, bonded particles, and combinations thereof assembled in a scaffold which has a porosity of between about 15 and
about 90 vol % with at least about 75 vol % of pores being interconnected and suitable for application to a mammalian host
such that it is exposed to the mammalian host's bodily fluids for tissue repair or regeneration in mammals; and

wherein the composition is not water soluble.

US Pat. No. 9,486,747

NANOCOMPOSITE MEMBRANES WITH ADVANCED ANTIFOULING PROPERTIES UNDER VISIBLE LIGHT IRRADIATION

The Curators of the Unive...

1. Antifouling membranes for use in water treatment and materials separation, the membranes having integrating fillers with
visible light photocatalytic activity comprising nitrogen—doped TiO2 nanoparticles used to produce Poly(vinyledene fluoride) PVDF/N—TiO2 mixed matrix hollow fiber membranes (HFMs) which are activated by visible light, the membranes exhibiting an enhanced surface
hydrophilicity compared to a PVDF membrane, and with the fillers also affecting a surface cleaning through a photodegradation
process resulting from visible light irradiation so to enhance the fouling resistance of the membranes to organic materials
and biomaterials compared to a PVDF membrane.

US Pat. No. 9,435,039

PROTECTIVE CONVERSION COATING ON MIXED-METAL SUBSTRATES AND METHODS THEREOF

The Curators Of The Unive...

1. A method of forming a protective conversion coating on a mixed-metal substrate, the method comprising:
contacting a cerium salt and an oxidizing agent, sufficient to form a protective conversion coating solution;
providing a mixed-metal substrate having a plurality of joined metal surfaces, at least one of the surfaces comprising magnesium,
and at least one of the surfaces comprising ferrous metal, zinc, or aluminum; and

depositing the protective conversion coating solution on each metal surface of the mixed-metal substrate to form a protective
metal coating conversion solution layer, and wherein any metal present is selected from the group consisting of cerium and
one or more metals of the mixed-metal substrate.

US Pat. No. 9,395,353

NANOPORE-FACILITATED SINGLE MOLECULE DETECTION OF NUCLEIC ACID

The Curators of the Unive...

1. A method of detecting an oligonucleotide in a sample with a nanopore system, comprising the steps of:
a) mixing a sample suspected of comprising a target oligonucleotide and a probe, said probe comprising a central domain with
a complementary sequence to said target oligonucleotide and a terminal extension tagged to at least one of a 3? terminal or
a 5? terminal of the central domain, to produce a sample mixture wherein said central domain of said probe hybridizes to said
target oligonucleotide,

b) applying a voltage to said sample mixture in a cis compartment of a dual chamber nanopore system sufficient to drive translocation
of said hybridized probe and target oligonucleotide through a nanopore of said system by an unzipping process, and

c) analyzing an electrical current pattern in said nanopore system over time,
wherein a presence of said target oligonucleotide in said sample is indicated by at least one signature electrical current
block that is distinct from a background electrical current block that occurs with said sample alone or said probe alone.

US Pat. No. 9,652,691

METHOD OF PREDICTING CROP YIELD LOSS DUE TO N-DEFICIENCY

The Curators of the Unive...

1. A method for determining a crop yield loss due to nitrogen deficiency in at least one or more crop fields based on an analysis
of at least one or more remote sensing images, the method comprising:
a. obtaining the one or more remote sensing images of the one or more crop fields;
b. calculating a color value for each pixel of the one or more remote sensing images or a polygon comprising an aggregation
of pixels of the one or more remote sensing images, wherein the color value is an individual wavelength or a combination index
value comprising at least two wavelengths;

c. selecting a reference color value for the field that represents the color value of crop plants with sufficient nitrogen,
to be the same wavelength or combination of wavelengths used in (b);

d. calculating a relative color value of each pixel or polygon in the one or more remote sensing images by quantitatively
comparing the color value from that pixel or polygon from (b) to the reference color value from (c);

e. estimating a yield loss of each pixel or polygon from its relative color value using an empirically determined mathematical
relationship between the two quantities; and

f. presenting a summary of all yield loss estimates for the field,
wherein the yield loss comprises a decrease in crop yield per land area of a crop.
US Pat. No. 9,598,352

PROCESS AND DEVICE FOR THE PRODUCTION OF POLYHEDRAL BORANES

The Curators of the Unive...

1. A process for the production of a polyhedral borane in an amount greater than one kilogram, wherein the process comprises
a solid-phase, anhydrous, one-pot reaction of a tetraborohydride and a quaternary amine salt under anhydrous pyrolytic reaction
conditions without solvent, resulting in the formation of the polyhedral borane.
US Pat. No. 9,561,250

SCAFFOLD FOR TISSUE REGENERATION IN MAMMALS

The Curators of the Unive...


wherein two or more of Li2O, Na2O, K2O, and Rb2O are present in a cumulative concentration between about 1 and about 50 wt %,

wherein two or more of MgO, SrO, BaO, and CaO are present in a cumulative concentration between about 1 and about 50 wt %,
wherein the scaffold body has a porosity between about 15 and about 90 vol %.

US Pat. No. 9,427,483

RADIOISOTOPE TRITHIOL COMPLEXES

THE CURATORS OF THE UNIVE...

1. A radioisotope trithiol complex according to Formula I:

wherein each R1 is independently C1 to C5 substituted or unsubstituted hydrocarbyl;

mM is a radioisotope; and

X is a chemical moiety.

US Pat. No. 9,260,581

MULTIFUNCTIONAL POROUS ARAMIDS (AEROGELS) AND FABRICATION THEREOF

THE CURATORS OF THE UNIVE...

1. A polymeric ferrocene carboxamide aerogel comprising the following repeating units:

wherein:
G represents a group selected from aryl, (aryl)-R-(aryl), and (aryl)-R-(aryl)2; where each aryl independently represents an optionally substituted aromatic ring; and where R is a bond or a C1-C6 straight chain or branched chain alkyl group;

G2 represents a ferrocenyl moiety; and

(*) denotes a linkage point.
US Pat. No. 9,133,251

BACILLUS BASED DELIVERY SYSTEM AND METHODS OF USE

The Curators of the Unive...

1. A Bacillus exosporium molecule delivery (BEMD) system comprising a recombinant Bacillus cereus family member expressing a fusion construct, wherein the fusion construct comprises at least one molecule of interest (MOI)
and:
(a) a targeting sequence consisting of a 16 amino acid sequence having at least 43% identity with amino acids 20-35 of SEQ
ID NO.7, wherein the identity with amino acids 25-35is at least 54%;

(b) a targeting sequence consisting of amino acids 1-35 of SEQ ID NO. 7;
(c) a targeting sequence consisting of amino acids 20-35 of SEQ ID NO. 7;
(d) a targeting sequence comprising SEQ ID NO. 13;
(e) a targeting sequence consisting of SEQ ID NO.7;
(f) a targeting sequence comprising amino acids 1-27 of SEQ ID NO. 8;
(g) a targeting sequence comprising amino acids 12-27 of SEQ ID NO. 8;
(h) a targeting sequence comprising SEQ ID NO. 8;
(i) an amino acid sequence comprising the amino acid sequence encoded by the entire open reading frame of BAS3290, wherein
BAS3290 comprises an N-terminal domain comprising SEQ ID NO: 8;

(j) a targeting sequence comprising amino acids 1-38 of SEQ ID NO. 9;
(k) a targeting sequence comprising amino acids 23-38 of SEQ ID NO. 9;
(l) a targeting sequence comprising SEQ ID NO. 9; or
(m) a targeting sequence comprising a methionine residue covalently bound to an amino acid sequence consisting of 16 amino
acids having at least 43% identity with amino acids 20-35 of SEQ ID NO.7, wherein the identity with amino acids 25-35 is at
least 54%.

US Pat. No. 9,593,225

MULTIFUNCTIONAL POROUS ARAMIDS (AEROGELS), FABRICATION THEREOF, AND CATALYTIC COMPOSITIONS DERIVED THEREFROM

The Curators of the Unive...

1. A composition of matter comprising a carbonizable polymeric aerogel incorporating ferrocene in every repeating unit, wherein
said polymeric aerogel comprises the following repeating units:
wherein:
G represents a group selected from aryl, (aryl)-R-(aryl), and (aryl)-R-(aryl)2; where each aryl independently represents an optionally substituted aromatic ring; and where R is a bond or a C1-C6 straight chain or branched chain alkyl group;

G2 represents a ferrocenyl moiety;

(*) denotes a linkage point; andwherein the polymeric aerogel includes a mixture of polyamide and polyurea.
US Pat. No. 9,549,998

STABILIZED GOLD NANOPARTICLE AND CONTRAST AGENT

The Curators of the Unive...

1. A kit for providing a contrast enhancer in a mammal for contrasting during imaging of the mammal, the kit consisting of:
gold nanoparticles functionalized with a biomolecule for engagement with a target portion of the mammal, wherein the gold
nanoparticles are directly coated with bisphosphonate and gum arabic; and

an aqueous solution of the gum arabic.

US Pat. No. 9,316,734

FREE-HAND SCANNING AND IMAGING

The Curators of the Unive...

1. A wideband synthetic aperture radar (SAR) imaging system, comprising:
a probe having an aperture through which a signal is transmitted incident to an object located in a medium of interest remotely
from the probe and through which a plurality of nonuniformly sampled reflected signals from the object are received by the
probe as the probe moves in a measurement plane located a predetermined distance from the object;

a memory for storing measurement data representative of the reflected signals collected by the probe;
a processor for executing a plurality of computer-executable instructions for a SAR-based reconstruction algorithm, said instructions
comprising:

instructions for performing a spectral estimation based on the measurement data;
instructions for transforming a frequency component of the spectral estimation as a function of the medium of interest;
instructions for obtaining an intermediate three-dimensional SAR image from the transformed spectral estimation data using
Fourier transforms;

instructions for segmenting the intermediate three-dimensional SAR image into a plurality of segments in an image domain,
wherein each segment includes a spatial bandwidth of a plurality of spatial bandwidths of the intermediate three-dimensional
SAR image;

instructions for transforming each of the plurality of segments from the image domain to a measurement domain, wherein each
of the plurality of segments is represented as partial data;

instructions for performing an optimization operation on each of the plurality of segments based on a comparison between the
partial data thereof and the measurement data;

instructions for recombining the plurality of segments to produce a final three-dimensional SAR image; and
a display responsive to the processor for presenting the final three-dimensional SAR image to a user.
US Pat. No. 9,528,169

METHOD FOR SEPARATION OF CHEMICALLY PURE OS FROM METAL MIXTURES

The Curators of the Unive...

1. A method of separating an amount of osmium from a mixture comprising the amount of osmium and at least one additional metal,
the method comprising:
contacting the mixture with an oxidizing solution to form a volatile OsO4 vapor;

bubbling the OsO4 vapor through a KOH trapping solution to form an amount of K2[OsO4(OH)2] dissolved in the KOH trapping solution;

contacting the dissolved K2[OsO4(OH)2] with a reducing agent to form an Os precipitate; and

separating the Os precipitate from the KOH trapping solution, wherein the mixture is an irradiated osmium metal target comprising
at least one osmium isotope selected from the group consisting of Os-184, Os-186, Os-187, Os-188, Os-189, Os-190, and Os-192.

US Pat. No. 9,530,991

VISCOUS SEALING GLASS COMPOSITIONS FOR SOLID OXIDE FUEL CELLS

MO-SCI Corporation, Roll...

1. A sealant for forming a seal between at least two solid oxide fuel cell components wherein the sealant comprises a glass
material comprising:
40-60 mol % B2O3 as a principal glass former,

10-25 mol % BaO,
10-25 mol % SiO2,

2-10 mol % Al2O3,

optionally one or more alkaline earth oxides selected from CaO, SrO, and MgO, and
optionally a transition metal oxide selected from among ZnO, La2O3, and ZrO2;

wherein the glass material is substantially alkali-free;
wherein the glass material contains no more than 15 vol. % crystallized material; and
wherein the sealant glass material demonstrates viscous self-healing from cracking in an SOFC operational range of 650° C.
to 850° C.

US Pat. No. 9,849,101

METHOD FOR ENHANCING AMIDOHYDROLASE ACTIVITY OF FATTY ACID AMIDE HYDROLASE

Research Foundation of th...

1. A method for enhancing amidohydrolase activity of fatty acid amide hydrolase in an animal, the method comprising
administering a composition of matter consisting essentially of a phenoxyacyl-ethanolamide to the animal such that hydrolysis
of N-acylethanolamines (NAEs) by fatty acid amide hydrolase (FAAH) in the animal is enhanced relative to a substantially identical
animal that has not been administered with the phenoxyacyl-ethanolamide, wherein the phenoxyacyl-ethanolamide is represented
by a structure:


wherein R is an aliphatic side chain.

US Pat. No. 9,597,016

ACTIVITY ANALYSIS, FALL DETECTION AND RISK ASSESSMENT SYSTEMS AND METHODS

The Curators of the Unive...

1. A method for determining whether a person has fallen or is at a high risk of falling, and notifying a caregiver when the
person has fallen or is at high risk of falling, the method comprising:
acquiring depth image data of a person, as the person walks within a particular area, utilizing at least one depth camera
of a risk assessment system, the at least one depth camera located in the particular area;

receiving the depth image data from the at least one depth camera by at least one processor of a computer-based remote device
of the risk assessment system, wherein the depth image data comprises a plurality of frames that depict the person walking
through a home environment over time, the frames comprising a plurality of pixels, the remote device located remotely from
the at least one depth camera, the remote device comprising electronic memory on which an image analysis application is electronically
stored, and the at least one processor structured and operable to execute the image analysis application;

segmenting, by the at least one processor, the pixels of the frames of the depth image data; in response to the segmenting,
(1) generating, by the at least one processor, a three-dimensional data object based on the analyzed depth image data, and
(2) tracking by the at least one processor, the three-dimensional data object over a plurality of frames of the depth images
data, wherein the tracked three-dimensional object comprises time-indexed spatial data that represents the person walking
through the home environment over time;

identifying, by the at least one processor, a walking sequence from the tracked three-dimensional object, wherein the identifying
step comprises:

the at least one processor determining a speed for the tracked three-dimensional data object over a time frame;
the at least one processor comparing the determined speed with a speed threshold;
in response to the comparison indicating that the determined speed is greater than the speed threshold, the at least one processor
assigning a state indicative of walking to the tracked three-dimensional data object;

while the tracked three-dimensional data object is in the assigned walking state:
the at least one processor determining a walk straightness for the tracked three-dimensional data object;
the at least one processor determining a walk length for the tracked three-dimensional data object;
the at least one processor determining a walk duration for the tracked three-dimensional data object;
the at least one processor saving the tracked three-dimensional data object in memory as the identified walking sequence when
(i) the determined walk straightness exceeds a straightness threshold, (ii) the determined walk length exceeds a walk length
threshold, and (iii) the determined walk duration exceeds a walk duration threshold;

the at least one processor excluding from the identified walking sequence in the memory the time-indexed spatial data from
the tracked three-dimensional data object corresponding to a time period where the determined walk straightness is less than
the walk straightness threshold;

the at least one processor repeating the speed determining step and the comparing step for the tracked three-dimensional data
object while the tracked three-dimensional data object is in the assigned walking state; and

the at least one processor assigning a state indicative of not walking to the tracked three-dimensional data object in response
to a determination that the speed of the tracked three-dimensional data object in the walking state has fallen below the speed
threshold;

analyzing by the at least one processor, the time-indexed spatial data from the identified walking sequence to generate one
or more gait parameters;

performing, by the at least one processor, at least one health risk assessment based on the one or more gait parameters to
determine a health risk assessment score for the person, the health risk assessment score indicative of a level of risk at
which the person is of falling;

analyzing, by the at least one processor, the health risk assessment score to determine whether an alert incident has occurred,
the alert incident indicating at least one of:

the person has fallen; and
a high risk of the person falling is present; and
generating and sending, by the at least one processor, an alert message to at least one caregiver electronic device when it
is determined that the health risk assessment score indicates an alert incident has occurred.

US Pat. No. 9,624,282

MICRODYSTROPHIN PEPTIDES AND METHODS FOR TREATING MUSCULAR DYSTROPHY USING THE SAME

THE CURATORS OF THE UNIVE...

1. A therapeutic composition comprising:
a microdystrophin peptide having an amino acid sequence which consists essentially of dystrophin spectrin-like repeats 16
and 17 (R16/R17) (SEQ ID NO:7); and

a delivery vehicle, wherein the delivery vehicle is a cell-penetrating peptide.
US Pat. No. 9,807,987

RECOMBINATION ACTIVATING GENE 2 GENE TARGETING VECTOR, PRODUCTION OF SCID-LIKE MINIATURE PIGS BY TALEN-MEDIATED GENE TARGETING AND USE THEREOF

KONKUK UNIVERSITY INDUSTR...

1. A method for producing severe combined immunodeficiency (SCID)-like miniature pigs having a recombination activating gene
(RAG) 2-allelic mutation, the method comprising:
inducing an allelic mutation in a pig RAG 2 gene by exposing the gene to a transcription activator-like effector nuclease
(TALEN) that recognizes a TALEN-recognizing sequence region as set forth in SEQ ID NO. 1 in Chromosome 2 of the pig;

producing mutant embryos by using cells comprising the induced allelic mutation, wherein the producing is performed by somatic
cell nuclear transplantation (SCNT); and

transferring the embryos to a surrogate gilt and allowing the embryos to gestate to term.

US Pat. No. 9,151,709

MULTIPLE PHASE FLOW SYSTEM FOR DETECTING AND ISOLATING SUBSTANCES

The Curators of the Unive...

1. A multiple flow system for detecting substances in a fluid, the system comprising:
a first fluid tube containing a first fluid, wherein the first fluid comprises a first type of analyte and a second type of
analyte;

a second fluid tube containing a second fluid, wherein the first fluid is different from the second fluid, wherein the first
and second fluids are immiscible;

a common fluid tube;
a connector coupled to the first fluid tube, the second fluid tube, and the common fluid tube, wherein fluid flows from the
first fluid tube and the second fluid tube into the common fluid tube via the connector such that alternating discrete compartments
of the first fluid and the second fluid flow through the common fluid tube; and

a substance detector coupled to the common fluid tube, the substance detector configured to receive each alternating discrete
compartment and analyze each alternating discrete compartment, wherein the substance detector comprises a flow chamber having
an internal wall, wherein the internal wall is made of acrylamide gel that provides an acoustic path from an excited cell
to an acoustic sensor, wherein the alternating discrete compartments flow through the flow chamber and are analyzed by the
substance detector such that the substance detector is configured to identify a first signal corresponding to detection of
the first type of analyte and a second signal corresponding to the second type of analyte, wherein the substance detector
comprises a photoacoustic laser, wherein the photoacoustic laser is directed transversely to the flow or along the axis of
the flow using an optical waveguide to irradiate the entire discrete compartments, wherein the multiple flow system is for
photoacoustic detection of circulating tumor cells.

US Pat. No. 9,593,052

ARSENIC COMPLEXES FOR POTENTIAL DIAGNOSTIC APPLICATIONS

The Curators of the Unive...

1. A method of producing radiolabeled phenylarsonic acid, the method comprising:
(a) contacting a radiolabeled no-carrier added arsenic acid with a monothiol to form a first solution; and
(b) contacting the first solution with a copper-based catalyst and a phenyldiazonium salt to give a second solution comprising
the radiolabeled phenylarsonic acid.

US Pat. No. 9,574,228

NANOPORE-FACILITATED SINGLE MOLECULE DETECTION OF NUCLEIC ACIDS

The Curators of the Unive...

1. A method of detecting a first target oligonucleotide in a sample, the method comprising:
combining the sample with a probe molecule, wherein the probe molecule comprises a terminal extension and a sequence that
is fully complementary or partially complementary to the first target oligonucleotide, such that the probe molecule and the
target oligonucleotide form a probe/target complex;

applying a voltage across a nanopore system while the probe/target complex is on a first side of a partition of the nanopore
system, the partition including an opening; and

analyzing an electrical current pattern in the nanopore system over time, wherein a presence of the first target oligonucleotide
in the sample is indicated by a signature electrical current pattern comprising three sequential levels of electrical current,
each level having a duration and a current amplitude different from the other levels of the three sequential levels.

US Pat. No. 9,956,277

BACILLUS BASED DELIVERY SYSTEM AND METHODS OF USE

The Curators of the Unive...

1. A Bacillus exosporium molecule delivery (BEMD) system comprising a recombinant Bacillus cereus family member expressing a fusion construct, wherein the fusion construct comprises at least one molecule of interest (MOI) and:(a) a targeting sequence comprising amino acids 1-28 of SEQ ID NO: 10;
(b) a targeting sequence comprising amino acids 13-28 of SEQ ID NO: 10;
(c) a targeting sequence comprising SEQ ID NO: 10; or
(d) a targeting sequence having at least 50% identity with amino acids 13-28 of SEQ ID NO: 10, wherein the identity with amino acids 18-28 of SEQ ID NO: 10 is at least 63%;
and wherein expression of the fusion construct results in display of the MOI on the exosporium of the recombinant Bacillus cereus family member.
US Pat. No. 9,611,353

DRUG LOADING PENTABLOCK POLYMERS

THE CURATORS OF THE UNIVE...

1. A pentablock polymer according to the formula CBABC, comprising:
polyethylene glycol (PEG);
polyglycolic acid (PGA) or polylactic acid (PLA); and
poly(?-caprolactone) (PCL);
wherein the pentablock polymer has a PCL-PLA-PEG-PLA-PCL configuration or PCL-PGA-PEG-PGA-PCL configuration.
US Pat. No. 9,783,779

ARTIFICIAL OOCYTE ACTIVATION

The Curators of the Unive...

1. A method of activating an unfertilized porcine oocyte comprising decreasing intracellular Zn2+ concentration of the oocyte by contacting the oocyte with a Zn2+ binding moiety comprising approximately 200 ?M TPEN (N,N,N?,N?-tetrakis(2-pyridylmethyl)ethane-1,2-diamine), wherein the
contacting results in activating the oocyte.

US Pat. No. 9,266,844

SUPPRESSION OF SARS REPLICATION BY SARS HELICASE INHIBITORS

The Curators of the Unive...

1. A pharmaceutical composition comprising a compound of formula I:

or a pharmaceutically acceptable salt thereof; and one or more pharmaceutically acceptable excipients or carriers, wherein
the excipient or carrier is selected from the group consisting of an ion exchanger, alumina, aluminum stearate, lecithin,
a serum protein, human serum albumin, phosphate, glycine, sorbic acid, potassium sorbate, vegetable fatty acids, protamine
sulfate, disodium hydrogen phosphate, potassium hydrogen phosphate, a zinc salt, colloidal silica, magnesium trisilicate,
polyvinyl pyrrolidone, cellulose, polyethylene glycol, sodium carboxymethylcellulose, polyacrylates, wax, polyethylene-polyoxypropylene-block
polymer, polyethylene glycol, wool fat, lactose, dried corn starch, Ringer's solution, dextrose, Hank's solution, ethyl oleate,
isopropyl myristate, sucrose, sorbitol, mannitol, gum acacia, calcium phosphate, mineral oil, cocoa butter, oil of theobroma,
alginates, tragacanth, gelatin, methylcellulose, polyoxyethylene, sorbitan monolaurate, methyl hydroxybenzoate, propyl hydroxybenzoate,
talc and magnesium stearate, alcohol, mineral oil, petrolatum, propylene glycol, polyoxyethylene, and polyoxypropylene.

US Pat. No. 9,732,379

ENCODED NANOPORE SENSOR FOR MULTIPLEX NUCLEIC ACIDS DETECTION

The Curators of the Unive...

1. A set of probe molecules comprising at least a first probe molecule and a second probe molecule each comprising:
a) a capture domain that comprises a sequence with complementarity to a target nucleic acid;
b) a terminal extension that is covalently linked to the 5? end, the 3? end, or both the 5? end and the 3? end of the capture
domain; and

c) at least one polymer label branched from an internal residue located within at least one of the terminal extension(s),
wherein the nucleic acid capture domain of the first probe molecule comprises a sequence with complementarity to first target
nucleic acid and the nucleic acid capture domain of the second probe molecule comprises a sequence with complementarity to
a second target nucleic acid, wherein the polymer label is a polyglycol selected from the group consisting of polyethylene
glycol (PEG), methoxypolyethylene glycol (MPEG), polypropylene glycol (PPG), polybutylene glycols (PBG), and copolymers thereof
wherein the polymer label of the first probe molecule is different from the polymer label of the second probe molecule, and
wherein the polymer labels of the first and second probe molecules provide for independent detection of the first and second
target nucleic acids in a nanopore system.

US Pat. No. 9,805,928

LOW TEMPERATURE NANOWIRE GROWTH ON ARBITRARY SUBSTRATES

The Curators of the Unive...

1. A method of producing nanowires on arbitrary substrate, said method comprising:
depositing a thin non-zinc metal seed layer as a heterogeneous seed layer on a substrate, the non-zinc metal comprising at
least one of silver (Ag), wherein the substrate is at least one of curved and flexible;

oxidizing the non-zinc metal seed layer to produce an oxidation layer on the non-zinc metal seed layer and to reduce lattice
mismatch between the non-zinc metal seed layer and nanowire to be grown on the oxidization layer, wherein the oxidization
layer comprises a uniform layer of one of Ag2O ions or hydroxide ions, and oxidizing the non-zinc metal seed layer comprises
allowing the non-zinc metal seed layer to naturally oxidize in ambient air for a selected amount of time to provide the oxidation
layer comprising a uniform layer of the one of Ag2O or hydroxide ions; and

submersing the substrate with the oxidized non-zinc metal seed layer into a growth solution at a temperature of 5° C. to 150°
C., the growth solution comprising Zn+2 ions whereby the Zn+2 ions replace the one of Ag2O ions or hydroxide ions to form
one or more uniform layers of ZnO nuclei from which nanowire will grow.

US Pat. No. 10,047,112

FLUORESCENT LABELED INHIBITORS

THE CURATORS OF THE UNIVE...

1. A compound comprising a cyclic enolphosphonate or a cyclic enolphosphate, having the structure:wherein n is any of 1 to 20: wherein R is alkyl, benzyl, or aryl; wherein R? is any of C1 to C20:wherein X is O or CH2; and wherein Y is a fluorescent label; orwherein n is any of 1 to 20; wherein R is alkyl, benzyl, or aryl; wherein R? is any of C1 to C20;wherein X is O or CH2; and wherein Y is a fluorescent label.
US Pat. No. 9,820,475

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS RESISTANT ANIMALS

The Curators of the Unive...

1. A genetically modified swine comprising inactivating mutations in both alleles of a CD163 gene, wherein the swine does
not comprise an inactivating mutation in an allele of a SIGLEC1 gene.

US Pat. No. 9,668,754

SYSTEM, APPARATUS, AND METHOD FOR GRAFTING TISSUE

The Curators of the Unive...

1. A cutting apparatus, comprising:
an annular cutting surface adapted to contract from a first diameter to a second diameter that is less than the first diameter
to provide a tapered tissue graft;

the tapered tissue graft having an exposed end and an insertion end separated by a length, the annular cutting surface adapted
to automatically contract over the length of the tapered tissue graft from the first diameter at the exposed end to the second
diameter at the insertion end, the length between the exposed end and the insertion end defining an external taper of the
tapered tissue graft.

US Pat. No. 9,771,577

METHODS FOR ANALYZING LARIAT RNA

THE CURATORS OF THE UNIVE...

1. A method of enriching an RNA population for lariat RNA comprising:
a. providing an RNA population isolated from a population of cells; and,
b. contacting the RNA population with (i) a 5? cap removing enzyme followed by a 5? exonuclease, (ii) a 3? exonuclease and
a 5? exonuclease with or without prior contact with a 5? cap removing enzyme, or (iii) a 5?/3? exonuclease with or without
prior contact with a 5? cap removing enzyme to form a lariat RNA enriched population.

US Pat. No. 10,070,889

INORGANIC PYROPHOSPHATE AND USES THEREOF

The Curators of the Unive...

1. A method of artificial insemination comprising providing sperm and inorganic pyrophosphate (PPi) to a reproductive tract of a female, wherein the concentration of PPi is between 1 ?M to 200 ?M.
US Pat. No. 10,058,079

INTERLEUKIN 2 RECEPTOR GAMMA GENE TARGETING VECTOR, PRODUCTION OF IMMUNE CELL-DEFICIENT TRANSGENIC CLONED MINI PIG HAVING VECTOR INTRODUCED THEREIN, PREPARATION METHOD THEREFOR AND USE THEREOF

KONKUK UNIVERSITY INDUSTR...

1. A method for producing an immune cell-deficient transgenic miniature pig having an allelic mutation that disrupts the interleukin-2 receptor gamma (IL2RG) gene, the method comprising the steps of:(a) introducing into a miniature pig somatic cell a TALEN that recognizes a TALEN recognition sequence, wherein the TALEN recognition sequence is nucleotides 1-19 and 32-50 of SEQ ID NO:1 of the IL2RG gene on chromosome X of the pig somatic cell, and wherein said TALEN produces a deletion of nucleotides 26-29 of SEQ ID NO:1 of the IL2RG gene, and wherein said deletion results in an allelic mutation represented by SEQ ID NO:24 and a premature stop codon in the IL2RG gene;
(b) producing a nuclear transfer miniature pig embryo by introducing the pig somatic cells produced in step (a) into enucleated miniature pig oocyte; and
(c) transferring the embryo into a surrogate gilt and allowing the embryo to gestate to term to produce a transgenic miniature pig comprising a disruption in the IL2RG gene on chromosome X, wherein said disruption ablates IL2RG expression, and wherein the transgenic pig is immune cell deficient.

US Pat. No. 9,689,964

ELECTRONIC RECEIVER DEVICE DETECTION SYSTEM AND METHOD

The Curators of the Unive...

8. An electronic receiver device detection system comprising:
a stimulation component comprising a signal generator to generate a radio-frequency (RF) stimulation signal and a receiver
to receive a response unintended electromagnetic emission (UEE) signal;

an alert device; and
a computing system comprising at least one processor and at least one memory for storing a statistical correlation component
executed by the at least one processor to:

generate a noise floor statistical self-similarity parameter for an area, the noise floor statistical self-similarity parameter
generated using the signal generator in the absence of any super regenerative receiver (SRR) in the area and prior to detecting
the response UEE signal;

store the generated noise floor statistical self-similarity parameter in the at least one memory;
receive via the receiver the response UEE signal emitted from the SRR within an area, the response UEE signal generated in
response to the RF stimulation signal that is transmitted in the area;

determine a SRR statistical self-similarity parameter from the response UEE signal; and
generate an alert signal by the alert device when the determined SRR statistical self-similarity parameter exceeds the noise
floor statistical self-similarity parameter.

US Pat. No. 9,728,660

OPTICALLY-TRIGGERED LINEAR OR AVALANCHE SOLID STATE SWITCH FOR HIGH POWER APPLICATIONS

The Curators of the Unive...

1. A modular laser-switched system comprising:
an optically-triggered switch array module, the array module comprising at least one optically-triggered switch, wherein the
at least one optically-triggered switch further comprises:

a substrate;
a semiconductor material having a top surface and a bottom surface,
wherein the bottom surface is connected to the substrate;
one or more conductive contacts connected to the top surface of the semiconductor material;
one or more grounding electrodes connected to a substrate bottom surface; and
wherein, the semiconductor material undergoes an avalanche breakdown providing a conductive region therein, when contacted
by an optical signal;

an energy storage system;
a power supply connected with the energy storage system and the optically-triggered switch array module;
a processing device comprising at least one processor and a user interface, the processing device connected with the energy
storage system, the power supply, and the optically-triggered switch array module; and

an antenna array comprising one or more antennas, wherein the antenna array is connected with the optically-triggered switch
array module.

US Pat. No. 9,716,202

OPTICALLY ACTIVATED LINEAR SWITCH FOR RADAR LIMITERS OR HIGH POWER SWITCHING APPLICATIONS

The Curators of the Unive...

14. An optically-activated semiconductor switch device configured as a switch, the switch device comprising:
at least one compensation-doped semiconductor material comprising nitride;
two or more conductive contacts engaged to a surface of the at least one compensation-doped semiconductor material, wherein
the two or more conductive contacts define an illumination region on the surface of the at least one compensation-doped semiconductor
material therebetween;

wherein the illumination region defines a conductive channel between the conductive contacts;
wherein an optical signal received at the illumination region on the surface decreases the resistance of the at least one
compensation-doped semiconductor material to permit an incident signal received at at least one of the two or more conductive
contacts to traverse the illumination region.

US Pat. No. 10,039,277

TISSUE PRESERVATION SYSTEM

The Curators of the Unive...

1. A process for osteochondral tissue preservation comprising storing the osteochondral tissue at room temperature in a container comprising a serum-free culture medium comprising dexamethasone for from about 7 days to about 70 days prior to implantation, wherein at least 70% of the cells of said osteochondral tissue remain viable after said storing compared to the viability of the cells of the osteochondral tissue at day 0.

US Pat. No. 10,080,570

SYSTEM, APPARATUS, AND METHOD FOR GRAFTING TISSUE

The Curators of the Unive...

1. A method of grafting tissue at a tissue site, comprising:inserting a tapered graft tissue having an external taper into a corresponding tapered socket at the tissue site, wherein the tapered graft tissue having an external taper is obtained by:
positioning a plunger at a distal end of an elongate housing defining a bore having a longitudinal axis to place an annular cutting surface defined by a plurality of elongate cutting members in a first diameter, the plunger having an external surface slidably disposed in the bore of the elongate housing, and wherein the elongate cutting members are biased against the external surface of the plunger at the distal end of the elongate housing;
inserting the annular cutting surface longitudinally into a donor tissue source;
displacing the plunger toward a proximal end of the elongate housing with donor tissue entering the bore of the elongate housing as the annular cutting surface advances into the donor tissue source; and
contracting the annular cutting surface from the first diameter to a second diameter that is less than the first diameter along a tapered profile as the plunger is displaced.

US Pat. No. 9,872,647

DETECTION OF EARLY STAGE ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT

The Curators of the Unive...

4. A system for screening a patient for Alzheimer's disease or mild cognitive impairment, the system comprising:
a microperimeter;
an optical coherence tomographer;
a computer having at least one processor, wherein the computer performs the following steps:
(A) receiving retinal sensitivity data from the microperimeter,
(B) receiving retinal thickness data from the optical coherence tomographer,
(C) comparing, with the at least one processor, the retinal sensitivity data and retinal thickness data with age and gender
matched control subjects, and

(D) based on the comparing, determining, with the at least one processor, whether to diagnose the patient with Alzheimer's
Disease or mild cognitive impairment, wherein the determining comprises diagnosing a patient with Alzheimer's Disease or mild
cognitive impairment when the retinal sensitivity data shows a reduction in sensitivity in the inner macula compared to the
age and gender matched control subjects and the retinal thickness data shows a reduction in thickness of the inner macula
compared to the age and gender matched control subjects, and wherein the diagnosing a patient with Alzheimer's Disease or
mild cognitive impairment comprises diagnosing the patient with Alzheimer's Disease when the retinal sensitivity data shows
a reduction in sensitivity of at least 20% of the inner macula and a reduction in sensitivity of at least 10% of the inferior,
temporal, and nasal portions of the retina compared to the age and gender matched control subjects.

US Pat. No. 9,862,697

PH-SENSITIVE FLUORESCENT SENSORS FOR BIOLOGICAL AMINES

The Curators of the Unive...

1. A fluorescence sensing compound for detecting and visualizing a synaptic release of one or more primary amine neurotransmitters,
the fluorescence sensing compound having the following formula:

wherein:
the sulfamidyl group at the C7-position is an electron-donor that confers an internal charge transfer mechanism to the compound
upon deprotonation, which occurs at a pH that is between that of a synaptic vesicle and that of a synaptic cleft;

the aldehyde group at the C3-position is an electron-acceptor and enables an iminium-ion formation with said primary amine
neurotransmitter(s);

R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkylene, aryl, and cycloakyl;

R3 is selected from the group consisting of hydrogen, alkyl, alkylene, aryl, and cycloakyl; and

the fluorescence sensing compound has a pKa that is in a range of 6.0 to 7.4.

US Pat. No. 10,133,045

OPTICAL POLARIZATION TRACTOGRAPHY METHODS

The Curators of the Unive...

1. A method of producing 3D images of a fibrous target tissue sample, the method comprising:focusing a polarized incident light with one or more optical polarizations in a first direction on one or more surface locations of a fibrous target tissue sample, whereby at each surface location of the incident light in the first direction the incident light propagates inside the fibrous target tissue sample and comes out from different depths within the fibrous target tissue sample to provide a first signal resulting from the incident light in the first direction;
analyzing polarization characteristics of the of first signal to derive fiber orientation data within the fibrous target tissue sample at each depth relative to a first projection plane defined by the first direction of the incident light and a 3D position of the fibrous target tissue sample;
constructing a first 3D image volume of fiber orientation of the fibrous target tissue sample utilizing the fiber orientation data derived at each depth relative to the first projection plane at each of the surface locations of the incident light in the first direction;
focusing the polarized incident light with one or more optical polarizations at at least one additional direction that is different than the first direction on one or more additional surface locations of the fibrous target tissue sample, whereby at each surface location of the incident light in the at least one additional direction the incident light propagates inside the fibrous target tissue sample and comes out from different depths within the fibrous target tissue sample to provide an additional signal resulting from the incident light in the at least one additional direction;
analyzing polarization characteristics of the additional signal to derive fiber orientation data at each depth within the fibrous target tissue sample relative to at least one additional projection plane defined by the at least one additional direction of the incident light and the 3D position of the fibrous target tissue sample;
constructing at least one additional 3D image volume of the fiber orientation of the fibrous target tissue sample utilizing the fiber orientation data derived at each of the depths relative to the at least one additional projection plane at each of the additional incident light surface locations;
registering the first 3D image volume of fiber orientation of the fibrous target tissue sample and the at least one additional 3D image volume of fiber orientation of the fibrous target tissue sample to construct a combined 3D image volume of 3D fiber orientation of the fibrous target tissue sample at the intersection of the first projection plane and the at least one additional projection plane;
determining 3D image properties of the fibrous target tissue sample utilizing the combined 3D image volume of the 3D fiber orientation of the fibrous target tissue sample; and
transmitting the 3D image properties of the fibrous target tissue sample to a processor to produce 3D images of the fibrous target tissue sample.
US Pat. No. 9,766,252

PEPTIDE WITH GOLD BINDING AND EGFR RECEPTOR AFFINITY AND SAME ATTACHED TO GOLD NANOSTRUCTURE

The Curators of the Unive...

1. A peptide comprising four domains, wherein domain I consists of thioctyl or monothiol, domain II consists of 2 to 3 positively
charged amino acids selected from the group consisting of lysine and arginine, domain III consists of a dimeric ethylene unit;
and domain IV comprises the peptide with SEQ ID No. 1.

US Pat. No. 9,976,011

POLYMER COMPOSITES AND FABRICATIONS THEREOF

THE CURATORS OF THE UNIVE...

1. A polymer composite, comprising: a polymer matrix and a reinforcing filler wherein the reinforcing filler comprises calcium phosphate nanofibers, submicron fibers, or combinations thereof, wherein the reinforcing filler has a gelatin coated surface comprising amine moieties, carboxylic acid moieties, or combinations thereof, and wherein the reinforcing filler has a diameter or thickness ranging between about 10 nm and about 1 ?m and an aspect ratio ranging between about 50 and about 5,000 and is present in an amount ranging from about 0.6 wt. % to about 15 wt. %.

US Pat. No. 9,888,909

ENDOSCOPIC-ENABLED TONGUE DEPRESSOR AND ASSOCIATED METHOD OF USE

THE CURATORS OF THE UNIVE...

1. An apparatus for opening upper airway during an upper airway procedure with accommodations for both intubation and visualization
comprising: a tongue-covering member configured to be inserted into a patient's mouth, said tongue-covering member having
a first groove/indentation on a back portion for placement of intubation tubing and a second groove/indentation on a top portion
for placement of an optic means, wherein both grooves/indentations are in the longitude direction along the entirety of said
tongue-covering member, wherein said second groove/indentation is a partially enclosed design that is enclosed at a proximal
end while open at a distal end, wherein said back portion is configured to be placed in direct contact with a patient's tongue
and said top portion is configured to be facing an upper airway of the patient's mouth, said first groove/indentation facing
the patient's tongue so that intubation tubing placed within the first groove/indentation is secured solely within the first
groove/indentation and configured for direct contact of the patient's tongue onto each the back portion and the placed intubation
tubing; and a handle member attaching to the proximal end of said tongue-covering member and securable to a mouth gag frame
while said tongue-covering member is inserted into said patient's mouth.

US Pat. No. 9,861,958

MULTIFUNCTIONAL CERIUM-BASED NANOMATERIALS AND METHODS FOR PRODUCING THE SAME

The Curators of The Unive...

1. A cerium-containing nano-coating composition, the composition comprising:
an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and
crystalline regions including one or more of crystalline cerium oxide, crystalline cerium hydroxide, and crystalline cerium
phosphate;

wherein the crystalline regions are embedded in the amorphous matrix, wherein the thickness of the amorphous matrix with embedded
crystalline regions is at least 100 nanometers and the diameter of each crystalline region is less than 50 nanometers.

US Pat. No. 10,103,357

FABRICATION OF MULTILAYER NANOGRATING STRUCTURES

The Curators of the Unive...

14. A nanograting structure, comprising:a substrate;
a polymer grating treated with a crosslinker,
wherein the polymer grating has been annealed for further crosslinking, and
wherein the polymer grating has been treated a hydrophilicity agent to render a surface of the polymer grating hydrophilic;
a fluorescence-enhancing reflective layer over the polymer grating; and
a capping layer on top of the reflective layer.
US Pat. No. 10,059,599

SYNTHESIS OF BORANE COMPOUNDS

THE CURATORS OF THE UNIVE...

1. A process for the synthesis of alkali metal tetrahydroborates comprising the following steps:first, reacting 10B-enriched boric acid with a C2-C4 alcohol in a reaction mixture that does not include toluene, xylene, mesitylene, benzene, or 1,2-dichlorhoethane to produce trialkylborate-10B;
second, reacting the trialkylborate-10B with a metal aluminum hydride in the presence of an amine to produce amine borane-10B; and
third, reacting the amine borane-10B with a reagent selected from the group consisting of alkali metal hydride and alkali metal methoxide to produce alkali metal tetrahydroborate-10B.

US Pat. No. 9,918,943

SYSTEMS AND METHODS FOR ENDOTOXIN REMOVAL FROM FLUIDS

The Curators of the Unive...

1. An endotoxin removal system, comprising:
a plurality of polymeric nanoparticles, each polymeric nanoparticle of the plurality of polymeric nanoparticles having a maximum
dimension between 300 nm and 500 nm; and

a support member associated with the plurality of polymeric nanoparticles, wherein, when an aqueous solution comprising endotoxin
molecules is exposed to the endotoxin removal system, the support member and the plurality of polymeric nanoparticles are
cooperatively configured to separate at least a portion of the endotoxin molecules from the aqueous solution, and wherein
each polymeric nanoparticle of the plurality of polymeric nanoparticles has an endotoxin removal capacity of at least 1×109 endotoxin units per gram of polymeric nanoparticle (EU/g).

US Pat. No. 9,901,617

CELL PERMEABLE INHIBITORS OF THE SCAFFOLD PROTEIN PLENTY OF SH3 DOMAINS (POSH) OR SH3RFL

The Curators of the Unive...

1. A composition comprising at least one chimeric peptide, wherein the at least one chimeric peptide comprises: i) a first
amino acid portion comprising the amino acid sequence selected from the group consisting of: EGKEPGDLKFSKGDIIILRR (SEQ ID
NO: 1); KEADKDCLPFAKDDVLTVIR (SEQ ID NO: 2); RKEDELELRKGEMFLVFER (SEQ ID NO: 3); PQSEAELELKEGDIVFVHKK (SEQ ID NO: 4); and
an amino acid sequence having over its total length at least 85% sequence identity with any one of SEQ ID NOs: 1 to 4; and
ii) a second amino acid portion comprising a cell internalization moiety adapted to internalize the at least one chimeric
peptide into a cell to bind to POSH (Plenty of SH3 Domains) for inhibiting and disrupting POSH scaffold networks.
US Pat. No. 9,885,040

SMN2 ELEMENT 1 ANTISENSE COMPOSITIONS AND METHODS AND USES THEREOF

The Curators of The Unive...

1. A composition for blocking the repressive activity of the Element 1 of the SMN2 pre-mRNA, the composition comprising an
antisense oligonucleotide that comprises the nucleic acid sequence SEQ ID NO: 17 (v1.11) or the nucleic acid sequence SEQ
ID NO: 17 (v1.11) except for consisting of one nucleotide substitution,
wherein the antisense oligonucleotide comprises a Morpholino backbone.

US Pat. No. 9,624,500

METABOLIC ENGINEERING OF PLANTS FOR INCREASED HOMOGENTISATE AND TOCOCHROMANOL PRODUCTION

The Curators of the Unive...

1. A plant comprising a mutated Glyma12g20220 allele, a representative sample of seed comprising said mutated allele having
been deposited under ATCC Accession No. PTA-12919.
US Pat. No. 10,045,973

COMPOSITIONS AND METHODS FOR TREATING NOCTURNAL ACID BREAKTHROUGH AND OTHER RELATED DISORDERS

THE CURATORS OF THE UNIVE...

1. A method for treating nocturnal acid breakthrough in a subject in need thereof, the method comprising: administering to the subject a solid pharmaceutical composition comprising an inner core, an outer layer, and at least one intermediate layer, wherein;(a) the inner core comprises an acid labile proton pump inhibitor that is not enteric coated and is present in the composition in an amount of about 5 mg to about 60 mg and is selected from the group of omeprazole, tenatoprazole, lansoprazole, rabeprazole, esomeprazole, pantoprazole, pariprazole, leminoprazole and nepaprazole or a free base, a free acid, or a salt, ester, amide, enantiomer, isomer, or tautomer of the proton pump inhibitor;
(b) the outer layer comprises a buffering agent that is present in the composition in an amount of about 300 mg to about 3000 mg and comprises a bicarbonate salt of a Group IA metal;
(c) the at least one intermediate layer that exists between the inner core and the outer layer and comprises an inert and non-pH sensitive coating materials;
(d) the administration step is performed between about 8:00 pm and about 12:00 am and at such a time so as to result in a blood serum concentration of the proton pump inhibitor of at least about 0.1 micromolar at any time point from about 12:00 am to about 6:00 am following administration; and
(e) upon administration of the composition to a subject, the subject exhibits a Cmax of the proton pump inhibitor of about 500 ?g/ml to about 2000 ?g/ml; a Tmax of the proton pump inhibitor of about 0.15 to about 2 hours; and/or an AUC(0-inf) of the proton pump inhibitor of about 1000 to about 3000 ng*hr/ml.
US Pat. No. 9,908,874

SEPARATION METHOD FOR ACTIVE PHARMACEUTICAL INGREDIENTS (APIS) FROM EXCIPIENTS IN PHARMACEUTICAL FORMULATIONS

The Curators of the Unive...

1. A method of physically separating an active pharmaceutical ingredient (API) from a pharmaceutical formulation comprising
an API and excipients, the method comprising:
providing the pharmaceutical formulation in powdered form, the powdered form comprising a mixture of API particulates and
excipient particulates;

generating a first liquid separation medium having a selected density greater than the density of the API particulates and
less than the density of at least a portion of the excipient particulates;

introducing the particulates to a vessel containing the first liquid separation medium;
centrifuging the vessel containing the first liquid separation medium and the particulates so that the particulates having
a density less than the density of the first liquid separation medium are floated to form a first floated fraction and the
particulates having a density greater than the first liquid separation medium forms a first pellet fraction at the bottom
of the vessel, the first floated fraction comprising at least a portion of the API particulates; and

removal of the first floated fraction comprising at least a portion of the API particulates;
wherein the API particulates are insoluble in the first liquid separation media and wherein the API particles have a density
of between about 1.1 g/cm3 to about 1.5 g/cm3.

US Pat. No. 10,128,111

LOW TEMPERATURE NANOWIRE GROWTH ON ARBITRARY SUBSTRATES

The Curators of the Unive...

1. A method of producing nanowires on arbitrary substrate, said method comprising:depositing a thin non-zinc metal seed layer as a heterogeneous seed layer on a substrate having a low melting point between 5° C. and 150° C., wherein the substrate is at least one of curved and flexible;
oxidizing the non-zinc metal seed layer at low temperature between 5° C. and 150° C. to produce an oxidation layer on the non-zinc metal seed layer and to reduce lattice mismatch between the non-zinc metal seed layer and nanowire to be grown on the oxidization layer, wherein the oxidization layer comprises a uniform layer of one of silver oxide ions or hydroxide ions; and
submersing the substrate with the oxidized non-zinc metal seed layer into a growth solution comprising Zn+2 ions whereby the Zn+2 ions replace the one of silver oxide ions or hydroxide ions to form one or more uniform layers of ZnO nuclei from which nanowire will grow,
wherein depositing the non-zinc metal seed layer comprises depositing a thin layer of at least one of silver (Ag), nickel (Ni), iron (Fe), aluminum (Al), titanium (Ti), molybdenum (Mo), tungsten (W), and copper (Cu) on the substrate, and
wherein oxidizing the non-zinc metal seed layer at low temperature comprises applying an oxidizing agent to the non-zinc metal seed layer, wherein the oxidizing agent comprises at least one of silver (Ag), copper (Cu), gold (Au), platinum (Pt), palladium (Pd) ions and related alloys.

US Pat. No. 9,958,561

APPARATUS AND METHOD FOR THE DETERMINATION OF ONE OR MORE NEUTRON SOURCE CHARACTERISTICS

The Curators of the Unive...

1. An apparatus for determination of one or more neutron source characteristics comprising:a neutron detector including:
a plurality of neutron detector assemblies, each of the neutron detector assemblies including a plurality of neutron detection devices, wherein the neutron detection devices are configured to detect one or more characteristics of neutrons emanating from one or more neutron sources and impinging on one or more neutron detection devices; and
a moderating volume, wherein the plurality of neutron detector assemblies are disposed within the moderating volume so as to form a three-dimensional array of neutron detection devices within the moderating volume, wherein the moderating volume is configured to moderate the energy of neutrons impinging on one or more of the neutron detector assemblies; and
an analyzer communicatively coupled to each of the neutron detection devices of the plurality of neutron detector assemblies, the analyzer configured to:
receive one or more measured response signals from each of the neutron detection devices, the one or more measured response signals indicative of a detected neutron event; and
perform one or more analysis procedures to determine one or more characteristics associated with the one or more neutron sources based at least on the received one or more measured response signals.

US Pat. No. 9,830,422

IN SILICO BIOLOGICAL AND PHARMACEUTICAL MODELING

The Curators of the Unive...

1. A computerized method carried out by at least one server having at least one processor for utilizing protein structural
information to superimpose multiple protein structures, the method comprising:
selecting a stationary template protein;
testing, using the at least one processor, a set of input mobile proteins against the template protein by rotating and translating
each mobile protein relative to the template protein in a three-dimensional (3D) coordinate space by a predefined distance
and predefined angle to generate a set of pseudostates for the each mobile protein;

scoring the set of pseudostates based on a statistical likelihood of superimposing on the template protein;
retaining as a subset of the set of pseudostates those pseudostates having scores above a predefined threshold;
iteratively optimizing and refining the subset of pseudostates for each mobile protein by incrementally decreasing the translational
and rotational coordinates until a predefined lower limit is reached to generate successive subsets of pseudostates, wherein
low-scoring pseudostates are eliminated after each iteration;

subsequent to this step, selecting as a new template protein a pseudostate having the least mean center error distance (MCED)
as compared to the remaining pseudostates;

testing the remaining pseudostates against the new template protein with the translational and rotational coordinates being
limited as a function of the each pseudostate's respective MCED such that the remaining pseudostates converge towards their
lower MCED; and

retaining as the each mobile protein's final structural alignment, the pseudostate having the highest statistical likelihood
of superimposing on the new template protein.

US Pat. No. 9,556,321

HIGH DIELECTRIC CONSTANT COMPOSITE MATERIALS AND METHODS OF MANUFACTURE

THE CURATORS OF THE UNIVE...

1. A composite material having a high dielectric constant greater than 20 and high dielectric strength of at least 1 MV/cm
, the composite material comprising:
a distribution of high dielectric constant ceramic particles dispersed in a polymeric material;
the polymeric material, wherein the polymeric material is cured and bonds directly to the distribution of high dielectric
constant ceramic particles;

wherein the distribution of high dielectric constant ceramic particles is a trimodal distribution; and
wherein a diameter of the ceramic particles of a largest diameter distribution of the trimodal distribution is between 40
?m and 220 ?m.

US Pat. No. 9,898,016

VARIABLE PRODUCT AGROCHEMICALS APPLICATION MANAGEMENT

The Curators of the Unive...

1. A computer-implemented method of managing application of agrochemical to an area made up of a plurality of location points
of land, the method comprising:
determining an attribute value, for each location point of said plurality of location points in an application area, that
represents a degree to which said location point possesses a certain characteristic, thereby resulting in a set of attribute
values;

delineating a first zone based on said set of attribute values, wherein said first zone is made up of location points having
attribute values belonging to a range of values;

from a set of agrochemical-application parameters, based on a subset of agrochemical application parameters that relate to
limitations of physically applying agrochemical, logically partitioning said application area to define at least one application
cell;

(1) wherein at least a portion of said first zone falls within said at least one application cell; and
(2) wherein said at least one application cell encompasses a subset of the plurality of location points, thereby resulting
in a subset of attribute values that are associated with said at least one application cell;

receiving at least one application parameter from said set of application parameters;
from among a number of agrochemical types, determining an application schedule of agrochemical to be applied to said application
cell based on said subset of attribute values and at least one application parameter, wherein said at least one agrochemical-application
parameter includes an attribute-value threshold; and further comprising:

comparing said attribute-value threshold to an attribute value representative of said first zone;
based on said comparison, designating said first zone for receiving a certain agrochemical type.

US Pat. No. 9,514,386

IDENTIFYING GEOGRAPHIC AREAS BASED ON CHANGE PATTERNS DETECTED FROM HIGH-RESOLUTION, REMOTELY SENSED IMAGERY

The Curators of the Unive...

1. One or more computer-readable media having computer-useable instructions embodied thereon for performing a method of utilizing
high-resolution remotely sensed imagery (“imagery”) to identify terrestrial objects that have changed in a certain manner,
the method comprising:
receiving a query that includes one or more inputs, which are related to 1) a first terrestrial object (“first object”) and
2) source change-detection information that describes change associated with the first object;

applying the query to a dataset that includes indexed information that describes the imagery;
based on the one or more inputs, determining a query result by:
(1) determining a source feature set that describes a set of features associated with the first object,
(2) comparing the determined source feature set against stored featured sets within the dataset,
(3) determining a set of regions in the dataset that:
i) have feature sets similar to the source feature set, and
ii) are respectively associated with change information that is similar to that of the source change-detection information,
wherein the query result comprises the determined set of regions; and

presenting on a presentation device indications of the query result comprising at least a portion of the identified set of
regions.

US Pat. No. 10,080,353

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS RESISTANT ANIMALS

The Curators of the Unive...

1. A genetically modified swine comprising an inactivating mutation in an allele of a CD163 gene.

US Pat. No. 9,984,781

SOLID-STATE NUCLEAR ENERGY CONVERSION SYSTEM

The Curators of the Unive...

1. A nuclear energy conversion system for providing current to a load comprising:a crystalline insulator;
a radiation source;
wherein radiation from the radiation source bombards said crystalline insulator to free a plurality of electrons from a lattice structure of said crystalline insulator;
wherein freeing said plurality of electrons from said lattice structure generates a plurality of holes;
a first electrode attached to a first end of said crystalline insulator and a second electrode attached to a second end of said crystalline insulator;
a voltage source connected in parallel to said crystalline insulator and the load;
wherein the voltage source biases said crystalline insulator such that said freed electrons collect at the first end and said holes collect at the second end causing a first current flow;
wherein said first current flow is supplied to the load; and
a diode connected in series with said voltage source and said load to inhibit a second current flow from the voltage source to the load.
US Pat. No. 9,687,477

MODULATION OF SPHINGOSINE 1-PHOSPHATE METABOLIZING ENZYMES FOR THE TREATMENT OF NEGATIVE-STRAND RNA VIRUS INFECTIONS

The Curators of the Unive...

1. A method of inhibiting the production of a negative-strand RNA virus in a eukaryotic cell, comprising administering a composition
comprising one or more agents which modulate the level or activity of a polypeptide involved in the synthesis or degradation
of sphingosine-1-phosphate in said cell, wherein said negative-strand RNA virus is in a family selected from the group consisting
of Orthomyxoviridae, Paramyxoviridae, Rhabdoviridae, Filoviridae, Bornaviridae, and Bunyaviridae.
US Pat. No. 10,091,975

PATHOGEN-RESISTANT ANIMALS HAVING MODIFIED CD163 GENES

The Curators of the Unive...

1. A porcine animal or offspring thereof or a porcine cell comprising a modified chromosomal sequence in at least one allele of a gene encoding a CD163 protein, wherein the modified chromosomal sequence in the at least one allele comprises a deletion and the deletion consists ofan 11 base pair deletion from nucleotide 3,137 to nucleotide 3,147 as compared to reference sequence SEQ ID NO: 47.

US Pat. No. 9,924,586

SYSTEMS AND METHODS TO GENERATE A SELF-CONFINED HIGH DENSITY AIR PLASMA

The Curators of the Unive...

8. An apparatus for generating a self-contained toroidal air plasma at an atmospheric pressure comprising:
a primary ignition region comprising a first shielding material that defines a first longitudinal cavity to contain a plasma
source;

an ignition device in communication with the primary ignition region to generate an air plasma from the plasma source;
a secondary ignition region adjacent to the primary ignition region, the secondary ignition region comprising a second shielding
material that defines a second longitudinal cavity, wherein the second longitudinal cavity is in fluid communication with
the first longitudinal cavity to receive the air plasma; and

a high voltage circuit comprising at least one capacitor, the high voltage circuit in communication with a voltage source
to apply a high voltage pulse to the air plasma, wherein the high voltage pulse heats and accelerates the air plasma away
from the apparatus to form the self-contained toroidal air plasma at the atmospheric pressure.

US Pat. No. 10,143,686

OXIDOSQUALENE CYCLASE AS A PROTEIN TARGET FOR ANTICANCER THERAPEUTICS

The Curators of the Unive...

1. A method of treating cancer comprising the step of administering to a patient in need thereof a therapeutically effective amount of an inhibitor of a protein target other than HMG-CoA reductase in the cholesterol biosynthetic pathway, wherein the inhibitor is a compound having the formula of Formula I:
or a salt thereof, wherein:
X is chosen from hydrogen, halogen, O, NR3R4, S, CH2, and CH;
Y is chosen from null, a bond, O and CH;
Z is chosen from O, N, and CH;
dashed bonds may be present or absent if present, the bond may be single or double as valency allows;
R, R1 and R2 are independently chosen from alkyl, alkene, aryl, alkyne, cycloalkyl, and alkylcycloalkylalkyl, any of which may be optionally substituted;
R3 and R4 are independently chosen from a bond, hydrogen, lower alkyl, lower alkene, lower alkyne, aryl, and cycloalkyl, any of which may be optionally substituted; and
Q is chosen from bromine, chlorine and fluorine; and wherein the compound is not PRIMA-1, wherein said protein target is oxidosqualene cyclase and wherein said cancer has cells selected from the group consisting of:
a) cancer cells that do not have a p53 mutation;
b) breast cancer cells which are HER2/neu positive
c) breast cancer cells which are estrogen receptor and progesterone receptor positive;
d) breast cancer cells which are triple negative for estrogen receptor, progesterone receptor, and HER2/neu; and
e) cancer cells that undergo apoptosis.
US Pat. No. 10,081,790

BACILLUS BASED DELIVERY SYSTEM AND METHODS OF USE

The Curators of the Unive...

1. A method of producing an energy source comprising distributing to a biomass material a recombinant Bacillus cereus family member expressing a fusion construct, wherein the fusion construct comprises at least one molecule of interest (MOI) and:(a) a targeting sequence comprising amino acids 1-28 of SEQ ID NO: 10;
(b) a targeting sequence comprising amino acids 13-28 of SEQ ID NO: 10;
(c) a targeting sequence comprising SEQ ID NO: 10;
(d) a targeting sequence having at least 50% identity with amino acids 13-28 of SEQ ID NO: 10, wherein the identity with amino acids 18-28 of SEQ ID NO: 10 is at least 63%; or
(e) a targeting sequence comprising at least the first 35 amino acids of a BacillusBclB protein;
wherein expression of the fusion construct results in display of the MOI on the exosporium of the recombinant Bacillus cereus family member; and wherein the MOI comprises an enzyme, the enzyme comprising an oxidoreductase, a transferase, a hydrolase, a lyase, an isomerase, a ligase, a ?-galactosidase, a lipase, a hydrogenase, a laccase, a redox enzyme, or an enzyme capable of hydrolyzing starch, sucrose, lactose, cellulose, or hemicellulose into fermentable sugars.

US Pat. No. 10,073,200

NANO-GAP GRATING DEVICES WITH ENHANCED OPTICAL PROPERTIES AND METHODS OF FABRICATION

The Curators of the Unive...

1. A grating structure comprising:a substrate including a smooth upper surface;
a base layer positioned on the substrate, the base layer including
a first surface with a plurality of grating elements positioned adjacent one another, each grating element including a longitudinal peak and a longitudinal valley, and
a second surface, opposing the first surface, in contact with the upper surface of the substrate; and
a contiguous first functional layer conformally covering the second surface of the base layer applied at a deposition angle away from normal on the second surface of the base layer, such that the first functional layer has a non-uniform thickness and such that the deposition angle of the first functional layer produces an enhanced fluorescence of a sample,
wherein the first functional layer includes a nanogap in the longitudinal valley,
wherein the nanogap measures between 10 nanometers and 30 nanometers in lateral width; and
wherein the nanogap produces the fluorescence enhancement in the vicinity of the nanogap.

US Pat. No. 9,994,516

FLEXIBLE TO RIGID NANOPOROUS POLYURETHANE-ACRYLATE (PUAC) TYPE MATERIALS FOR STRUCTURAL AND THERMAL INSULATION APPLICATIONS

The Curators of The Unive...

1. A norbornene-containing star monomer formed by the reaction of a norbornene-containing hydroxyl compound of the formula (IX)
with a tris(isocyanatophenyl)methane of formula (III)

wherein W is a C1-C6 straight chain or branched alkyl or alkoxyalkyl group;
wherein R1, R2, and R3 are each independently hydrogen or C1-C6 straight chain or branched alkyl group; and,
wherein m is an integer from 1 to 5.

US Pat. No. 9,929,654

HIGH VOLTAGE GAIN DC/DC POWER ELECTRONIC CONVERTERS

The Curators of the Unive...

7. A non-isolated DC/DC power converter providing high voltage gain using integrated voltage multiplier (VM) stages, the power converter comprising:a first boost stage performing a first sequence according to a first control signal, the first sequence comprising a first storing sequence and a first releasing sequence;
a second boost stage electrically connected with the first boost stage and performing a second sequence according to a second control signal, the second sequence distinct from the first sequence and comprising a second storing sequence and a second releasing sequence;
a first VM stage electrically connected in parallel between the first boost stage and the second boost stage, the first VM stage comprising a first diode and a first capacitor; and,
a second VM stage electrically connected in series between the first diode and the first boost stage, the second VM stage comprising a second diode and a second capacitor;
wherein the first VM stage receives energy from the first boost stage during the first storing sequence; and,
wherein the second VM stage receives energy from the second boost stage and from the first capacitor of the first VM stage during the second releasing sequence.
US Pat. No. 10,240,163

INCREASING THE CONTENT OF LONG CHAIN FATTY ACIDS IN SEED OIL

Donald Danforth Plant Sci...

1. A method selected from the group consisting of:(i) producing an enhanced amount of oil in seeds of an oilseed plant compared to the amount of oil produced in seeds by an otherwise identical control oilseed plant grown under the same conditions;
(ii) producing oil in seeds of an oilseed plant containing an enhanced amount of C20 and C22 fatty acids compared to the amount of C20 and C22 fatty acids in oil produced in seeds by an otherwise identical control oilseed plant grown under the same conditions;
(iii) producing oil in seeds of an oilseed plant containing an enhanced amount of C56, C58, and C60 triacylglycerols compared to the amount of C56, C58, and C60 triacylglycerols in oil produced in seeds by an otherwise identical control oilseed plant grown under the same conditions;
(iv) producing an enhanced amount of oil in seeds of an oilseed plant containing an enhanced amount of C20 and C22 fatty acids compared to the amount of oil and C20 and C22 fatty acids produced in seeds by an otherwise identical control oilseed plant grown under the same conditions;
(v) producing an enhanced amount of oil in seeds of an oilseed plant containing an enhanced amount of C56, C58, and C60 triacylglycerols compared to the amount of oil and C56, C58, and C60 triacylglycerols produced in seeds by an otherwise identical control oilseed plant grown under the same conditions;
(vi) producing an enhanced amount of oil in seeds of an oilseed plant containing an enhanced amount of C20 and C22 fatty acids and an enhanced amount of C56, C58, and C60 triacylglycerols compared to the amount of oil, C20 and C22 fatty acids, and C56, C58, and C60 triacylglycerols, respectively, produced in seeds by an otherwise identical control oilseed plant grown under the same conditions; and
(vii) producing enhanced levels of mRNA transcripts for one or more genes selected from the group consisting of glycerol-3-phosphate acyltransferase (GPAT), lysophosphatidic acid acyltransferase (LPAT), phosphatidic acid phosphohydrolase (PAH), and diacylglycerol acyltransferase (DGAT) in seeds of an oilseed plant compared to the levels of mRNA transcripts for said genes produced in seeds by an otherwise identical control oilseed plant grown under the same conditions,
wherein said oilseed plant is a plant other than Arabidopsis,
wherein said method comprises expressing a pPLAIII? protein from a heterologous nucleotide sequence in the genome of the plant, the pPLAIII? protein having at least 95% sequence similarity to an Arabidopsis pPLAIII? protein of SEQ ID NO: 57, and
wherein said pPLAIII? protein exhibits enzymatic activity in the range of from about 75% to about 125% or more of the enzymatic activity of said Arabidopsis pPLAIII? protein of SEQ ID NO 57.

US Pat. No. 10,067,079

SOLID STATE NMR SPECTROSCOPY/IMAGING IN SITU MEASURING DEVICES AND METHODS FOR CALIBRATION AND DETERMINING ONE OR MORE QUANTITATIVE PROPERTIES OF A TARGET SAMPLE

The Curators of the Unive...

1. A method for performing one or more quantitative measurements of a target sample using solid state Magic Angle Spinning (MAS) Nuclear Magnetic Resonance (NMR) spectroscopy, the method comprising:providing an in situ measuring device, the in situ measuring device comprising a solid state MAS NMR rotor and at least one sealed capillary tube positioned inside the solid state MAS NMR rotor, the at least one sealed capillary tube having a reference material sealed inside the at least one capillary tube between first and second fused glass ends of the at least one sealed capillary tube, wherein a target sample is positioned on the inside of the solid state MAS NMR rotor, and wherein a first portion of the target sample is in contact with an inner surface of the solid state MAS NMR rotor and a second portion of the target sample is in contact with an outer surface of the at least one sealed capillary tube;
obtaining MAS NMR spectra of the target sample and the reference material; and
determining one or more quantitative properties of the target sample, the one or more quantitative properties comprising one or more of a quantity of the target sample, a chemical identity of the target sample, or a temperature of the target sample.
US Pat. No. 10,138,273

PEPTIDE LIGANDS FOR HEPATIC STELLATE CELLS

The Curators of the Unive...

1. A composition comprising:a polypeptide comprising an amino acid sequence having the amino acid sequence of SEQ ID NO: 6, wherein the polypeptide binds to at least a portion of an insulin-like growth factor 2 receptor (IGF2R) extracellular domain; and
at least one of an anti-fibrotic agent, an anti-cancer agent, or a proapoptotic agent.

US Pat. No. 10,080,513

ACTIVITY ANALYSIS, FALL DETECTION AND RISK ASSESSMENT SYSTEMS AND METHODS

The Curators of the Unive...

1. A method for determining the risk of a person to falling, the method comprising:acquiring by at least one processor of a computer-based remote device, depth image data from at least one depth camera, wherein the depth image data comprises a plurality of frames that depict the person moving within an observation environment over time, the frames comprising a plurality of pixels, the remote device located remotely from the at least one depth camera, the remote device comprising electronic memory on which an image analysis application is electronically stored, and the at least one processor structured and operable to execute the image analysis application;
extracting, by the at least one processor, a foreground object from the depth image data;
segmenting, by the at least one processor, the pixels of the frames of the depth image data corresponding to the foreground object;
generating, by the at least one processor, a three-dimensional data object based on the foreground object, the three-dimensional data object representative of the person within the observation environment;
tracking, by the at least one processor, the three-dimensional data object over a plurality of frames of the depth images data; and
determining, by the at least one processor, that the person is walking within the observation environment, wherein the determining the person is walking comprises:
determining, by the at least one processor, a speed for the tracked three-dimensional data object over a time frame;
comparing, by the at least one processor, the determined speed with a speed threshold; and
stipulating the person to be walking wherein the determined speed is greater than the speed threshold;
assigning, by the at least one processor, a state indicative of the walking to the tracked three-dimensional data object;
then, once the person has been determined to be walking and the tracked three-dimensional object has been assigned a state indicative of walking:
determining, by the at least one processor, a walk straightness for the tracked three-dimensional data object;
determining, by the at least one processor, a walk length for the tracked three-dimensional data object;
determining, by the at least one processor, a walk duration for the tracked three-dimensional data object;
identifying and saving, by the at least one processor, the tracked three-dimensional data object in memory as a walking sequence when the determined walk straightness exceeds a straightness threshold, the determined walk length exceeds a walk length threshold, and the determined walk duration exceeds a walk duration threshold;
generating, by the at least one processor, one or more gait parameters from the identified walking sequence; and
determining a level of risk at which the person is of falling by comparing, by the at least one processor, the one or more gait parameters against a standard clinical measure of the one or more gait parameters.

US Pat. No. 9,827,323

CONJUGATED POLYMERIC MATERIAL AND USES THEREOF

THE CURATORS OF THE UNIVE...

1. A composition comprising collagen covalently bound to particles, wherein covalent amide bonds are formed between free carboxylic
acid groups of isolated or purified collagen and amine reactive groups of the particles, wherein the particles have an average
particle diameter size ranging from 50 to 1000 nanometers, and wherein collagen is not cross-linked through the particles,
and wherein the particles comprise ceramic material, biodegradable material, or metallic material of gold, silver, platinum,
titanium, nickel, or copper.
US Pat. No. 10,087,454

METHOD TO DEVELOP HIGH OLEIC ACID SOYBEANS USING CONVENTIONAL SOYBEAN BREEDING TECHNIQUES

THE CURATORS OF THE UNIVE...

1. A stably reproducing population of soybean seeds comprising a first polynucleotide sequence encoding a mutant FAD2-1A and a second polynucleotide sequence encoding a mutant FAD2-1B, whereinsaid first polynucleotide sequence comprises a single base deletion of adenine (A) at position 543 or 544 of SEQ ID NO: 9, said FAD2-1A mutant is nonfunctional or has a reduced activity compared to wild-type FAD2-1A; and
said second nucleotide sequence is selected from the group consisting of (a) a polynucleotide sequence encoding a FAD2-1B mutant which includes at least one mutation comprising a non-conserved amino acid substitution at amino acid position 137 of SEQ ID NO: 12, and (b) a polynucleotide sequence encoding a FAD2-1B mutant which includes at least one mutation comprising a non-conserved amino acid substitution at amino acid position 143 of SEQ ID NO: 12, said FAD2-1B mutant is nonfunctional or has reduced activity compared to wild-type FAD2-1B,
wherein oil from said population of soybean seeds has about 65% to about 85% oleic acid content.

US Pat. No. 10,083,770

HIGH ENERGY-DENSITY RADIOISOTOPE MICRO POWER SOURCES

The Curators of the Unive...

7. A solid-state high energy-density micro radioisotope power source device; said device comprising:a dielectric and radiation shielding body having an internal cavity formed therein;
an ohmic contact layer comprising a conductive material disposed at a first end of the cavity, and a rectifying contact layer comprising a conductive material disposed at an opposing second end of the cavity and spaced apart from the ohmic contact layer such that a micro chamber is provided therebetween;
a solid-state composite voltaic semiconductor disposed within the micro chamber between and in contact with the ohmic contact layer and the rectifying layer, the solid-state composite voltaic semiconductor comprising at least one non-radioactive semiconductor material uniformly mixed with at least one radioisotope material; and
a rectifying junction formed between the rectifying contact layer and the solid-state composite voltaic semiconductor, the rectifying junction having a depletion region within the solid-state composite voltaic semiconductor that converts the energy of the radioisotope material uniformly mixed with the at least one non-radioactive semiconductor material to an electric field generated within the depletion region.
US Pat. No. 10,548,989

NANOPARTICLE IMMUNOCONJUGATES

Memorial Sloan Kettering ...

1. An immunoconjugate comprising:a nanoparticle coated with an organic polymer; and
an antibody fragment conjugated to the organic polymer-coated nanoparticle,
wherein the nanoparticle has a diameter no greater than 20 nanometers,
wherein the nanoparticle comprises a silica-based core and a silica shell surrounding at least a portion of the core, and
wherein the antibody fragment is a single chain variable fragment (scFv).

US Pat. No. 10,447,135

DEVICE FOR GENERATING ELECTRICAL POWER FROM LOW FREQUENCY OSCILLATIONS

The Curators of the Unive...

1. An energy harvesting device for generating electrical power from low frequency oscillations, the device comprising:a high-frequency cantilever having a free end;
a plurality of low-frequency cantilevers, each having a free end configured to contact the high-frequency cantilever in response to environmental vibrations having a frequency within a near-resonance frequency range associated with said low-frequency cantilever; and
a generator that produces electrical power in response to contact between at least one of the plurality of low-frequency cantilevers and the high-frequency cantilever.

US Pat. No. 10,295,487

IN SITU NMR PARAMETER MONITORING SYSTEMS AND METHODS FOR MEASURING PH AND TEMPERATURE

The Curators of the Unive...

1. A device for in situ pH monitoring of a sample using Nuclear Magnetic Resonance (NMR) spectroscopy, the device comprising:a sample housing member configured to house a target sample;
at least one pH sensor configured to exhibit an NMR spectral change due to a change in pH value of the target sample; and
a pH sensor containment member having an interior portion, the pH sensor containment member configured to maintain the at least one pH sensor in the interior portion, where the pH sensor containment member is positioned inside at least a portion of the sample housing member, wherein at least a portion of the pH sensor containment member comprises one or more pores, wherein the one or more pores are configured to allow bidirectional diffusion of hydronium cations and hydroxide anions while maintaining the at least one pH sensor in the interior portion and while precluding direct interaction of the at least one pH sensor and the target sample.
US Pat. No. 10,087,503

METHOD FOR SEPARATION OF CHEMICALLY PURE OS FROM METAL MIXTURES

The Curators of the Unive...

1. A method of producing an amount of chemically pure Re-186 isotope, comprising:irradiating a metal target comprising an amount of isotopically enriched osmium isotope consisting of Os-189, Os-192, or a combination thereof in a thermal proton flux to form a mixture comprising at least one osmium isotope and at least one additional metal comprising the Re-186 isotope;
contacting the mixture with an oxidizing solution to form a volatile OsO4 vapor comprising the at least one osmium isotope;
distilling the OsO4 vapor from the oxidizing solution to form a second solution comprising the Re-186 isotope dissolved in the oxidizing solution; and
separating the Re-186 isotope from the second solution.

US Pat. No. 10,547,044

DRY POWDER BASED ELECTRODE ADDITIVE MANUFACTURING

Worcester Polytechnic Ins...

1. In battery electrode manufacturing, a method of depositing an electrode material on a planar substrate comprising:depositing onto a substrate defined by a planar electrode, a dry electrode mixture resulting from a combination of a plurality of types of constituent particles, the particle types including at least an active charge material and a binder, depositing further including:
generating a fluidized mixture of constituent particles of the dry electrode mixture using a carrier gas;
dispensing the dry electrode mixture onto a mold, the mold having an array of receptacles, each receptacle defining a shape and a spacing from adjacent receptacles to form a plurality of molded structures on the substrate;
inverting the mold onto the substrate; and
releasing the molded structures onto the substrate for forming a deposition pattern on the substrate corresponding to the array of receptacles;
heating the deposited mixture to activate the binder for adhering the mixture to the substrate; and
compressing the deposited mixture using heated rollers to a thickness for eliminating gaps between the molded structures and forming a continuous layer of charge material for achieving an electrical sufficiency of the compressed, deposited mixture as an electrode in a battery.

US Pat. No. 10,485,584

SUPPLEMENT FOR CULTIVATION OF MAMMALIAN EMBRYOS

Lekarska fakulta v Plzni,...

1. A method for in vitro cultivation of a mammalian embryo, comprising the step of incubating a fertilized oocyte in a culture medium containing N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine at least up to blastocyst stage.

US Pat. No. 10,101,059

THERMALLY DRIVEN HEAT PUMP FOR HEATING AND COOLING

The Curators of the Unive...

1. A thermally driven heat pump comprising:a low temperature evaporator for evaporating a cooling fluid to remove heat;
a primary fluid evaporator for evaporating primary fluid by application of heat;
an ejector including a converging/diverging chamber, nozzle apparatus in fluid communication with the primary fluid evaporator to receive the primary fluid vapor and to eject the primary fluid vapor into the converging/diverging chamber, the low temperature evaporator being in fluid communication with the converging/diverging chamber so that cooling fluid vapor from the low temperature evaporator is aspirated into the converging/diverging chamber;
a heat exchanger located at an outlet of the converging/diverging chamber of the ejector for receiving a flow of the primary fluid vapor and the cooling fluid vapor ejected from the ejector for condensing a portion of at least one of the cooling fluid vapor and the primary fluid vapor;
absorption apparatus located at the outlet of the converging/diverging chamber, the absorption apparatus including an absorber associated with the heat exchanger for absorbing the cooling fluid vapor into an absorbing fluid thereby to reduce a pressure in the heat exchanger;
a generator for separating the cooling fluid from the absorbing fluid; and
a separator in fluid communication with the heat exchanger, the low temperature evaporator and the primary fluid evaporator for use in separating the primary fluid from the cooling fluid for returning to the low temperature evaporator and the primary fluid evaporator, respectively.

US Pat. No. 10,591,418

FIBER-OPTIC MICRO-PROBES FOR MEASURING ACIDITY LEVEL, TEMPERATURE, AND ANTIGENS

The Curators of the Unive...

1. A micro-probe for measuring a non-cellular substance or an intracellular or intercellular pH of a cellular substance of a single cell, the micro-probe comprising:an elongated transparent shaft having opposing proximal and distal ends and tapering from the proximal end to the distal end such that the distal end is narrower than the proximal end, the shaft including a central fiber and a plurality of surrounding fibers twisted around the central fiber;
a mirror coating applied to at least a part of the central fiber;
mirror coatings applied to at least a part of the surrounding fibers;
a tip extending from the central fiber and surrounding fibers at the distal end of the shaft for contacting or being inserted into the substance;
a luminescent dye doped coating applied to at least part of the tip; and
a mirror coating applied to at least part of the tip,
wherein the micro-probe is configured such that:
a light ray transmitted through the central fiber will reflect off of the mirror coating of the central fiber so as to continue travelling through the central fiber towards the distal end of the shaft, enter into the tip, reflect off of the mirror coating of the tip, and be at least partially absorbed by the luminescent dye doped coating so that the luminescent dye doped coating emits a luminescent light signal having a property value indicative of the pH of the cellular substance, and
the luminescent light signal will pass from the tip into the surrounding fibers near the distal end of the shaft and reflect off of the mirror coatings of the surrounding fibers so as to propagate through the surrounding fibers towards the proximal end of the shaft so that the property value can be measured from the luminescent light signal for determining the pH of the cellular substance.

US Pat. No. 10,566,638

RADIOLYTIC ELECTROCHEMICAL GENERATOR

The Curators of the Unive...

1. A radiolytic electrochemical system comprising:(a) a cathode;
(b) an anode that comprises:
(i) a semiconductor component, wherein the semiconductor component has a nanoscale morphology that comprises nanopores that have an average diameter in a range 10 nm to 500 nm, wherein the nanopores are spaced a distance apart that is in a range of 10 nm to 500 ?m; and
(ii) a conduction component comprising an ohmic metal in contact with the semiconductor component thereby forming a non-rectifying metal-semiconductor junction; and
(c) an aqueous electrolyte solution in contact with the cathode and the anode, but not the conduction component of the anode, wherein solvated free radical ions are formed in the aqueous electrolyte solution when it is subjected to ionizing radiation of sufficient energy to split water molecules therein; and
(d) ionizing radiation, some of which splits water molecules in the aqueous electrolyte solution to form positively and negatively charged free radical ions that are solvated in the aqueous electrolyte solution; andwherein negatively charged solvated free radical ions are released from their surrounding water molecules and participate in redox reactions at the cathode/solution interface and positively charged solvated free radical ions are released from their surrounding water molecules and participate in redox reactions at the anode/solution interface thereby producing electrical current capable of performing work when the anode and cathode are electrically connected.

US Pat. No. 10,188,295

INTEGRATED SENSOR NETWORK METHODS AND SYSTEMS

The Curators of the Unive...

1. A method comprising:processing sensor data from a plurality of motion sensors and a bed sensor deployed in a living unit for a first time period to establish a frame of reference for an activity pattern by a person residing in the living unit, wherein the activity pattern frame of reference represents a health condition of a person residing in the living unit, wherein the processed sensor data for the first time period comprises a plurality of data values corresponding to a plurality of subintervals within the first time period, wherein each subinterval data value represents (1) a total number of sensor hits during that subinterval of the first time period or (2) a total time for sensor firings during that subinterval of the first time period, and wherein the activity pattern frame of reference comprises a statistical value about the subinterval data values over the first time period;
computing a standard deviation for the processed sensor data over the first time period based on the subinterval data values;
defining a statistical parameter threshold, wherein the statistical parameter threshold comprises a defined number of the standard deviations;
processing additional sensor data from the plurality of motion sensors and the bed sensor deployed in the living unit for a second time period, the second time period occurring after the first time period;
computing a value for the activity pattern for the second time period based on the processed additional sensor data, the computed activity pattern value of the second time period also representing a health condition of the person, wherein the computed activity pattern value comprises (1) data about a total number of sensor hits during the second time period if the activity pattern frame of reference is based on the total number of sensor hits during the first time period or (2) data about a total time for sensor firings during the second time period if the activity pattern frame of reference is based on the total time for sensor firings during the first time period;
comparing the computed activity pattern value with the activity pattern frame of reference and the defined statistical parameter threshold to determine whether the computed activity pattern value deviates from the activity pattern frame of reference by more than the defined number of the standard deviations;
generating an alert based on a determination that the computed activity pattern value deviates from the activity pattern frame of reference by more than the defined number of standard deviations;
receiving a feedback response to the alert, the feedback response including feedback regarding clinical relevance of the alert; and
adjusting the defined number of the standard deviations for the statistical parameter threshold to a different defined number of the standard deviations based on the feedback response to the alert.

US Pat. No. 10,434,032

INSTRUMENT-ASSISTED SOFT TISSUE MOBILIZATION TOOL

The Curators of the Unive...

15. A method of ameliorating bodily tissue comprising the steps of:a) identifying an area of the bodily tissue of a subject for amelioration,
b) providing a device for application to the bodily tissue comprising
a single-piece body having a substantially teardrop shaped longitudinal cross-section across an entire width of the body, the body comprising a first portion and a second portion,
the first portion comprising a substantially flat top surface, a substantially flat bottom surface, a continuously arcuate back disposed between the substantially flat top and bottom surfaces, and a first lateral side and an opposing second lateral side, the first portion providing a substantially bulbous handle part of the device adapted for ease of grasping and manipulation at the first portion, and
the second portion integrally formed with and extending longitudinally from the first portion and comprising a substantially tapered converging double-beveled lateral linear edge adapted for facilitated application to the bodily tissue at the second portion; the second portion additionally including at least one lip comprising a vertical wall extending substantially vertically from a surface of the second portion near the double-beveled lateral linear edge and a flat horizontal wall extending substantially orthogonally from the vertical wall, the at least one lip extending across substantially an entire width of the body,
c) grasping the device,
d) manipulating the device to contact the subject's bodily tissue with an application portion of the device, and
e) applying pressure to the bodily tissue of the subject.

US Pat. No. 10,364,195

BRAZE FOR CERAMIC AND CERAMIC MATRIX COMPOSITE COMPONENTS

Rolls-Royce Corporation, ...

1. A method comprising:positioning a first part comprising a ceramic or ceramic matrix composite (CMC) and a second part comprising a ceramic or a CMC adjacent to each other to define a joint region between adjacent portions of the first part and the second part;
delivering a solid braze material in the joint region, wherein the solid braze material comprises at least a filler material, an organic binder comprising a preceramic polymer, and a metal or alloy, and wherein the solid braze material comprises at least one of a wire, ribbon, thread, rod, or strand; and
locally heating, using at least one of a laser or a plasma arc source, the solid braze material, wherein a constituent of the filler material reacts with a constituent of the molten metal or alloy to join the first part and the second part.

US Pat. No. 10,301,719

AMORPHOUS HYDROGENATED BORON CARBIDE LOW-K DIELECTRIC AND METHOD OF MAKING THE SAME

The Curators of the Unive...

1. A method comprising:positioning the substrate within a plasma enhanced chemical vapor deposition (PECVD) chamber;
providing an ortho-carborane precursor;
passing a carrier gas through the ortho-carborane precursor, wherein the carrier gas uptakes at least a portion of the ortho-carborane precursor, wherein the carrier gas passed through the ortho-carborane precursor is provided at a partial flow rate of 90 to 97.5% of a total flow rate;
providing methane at a partial flow rate of 2.5 to 10% of the total flow rate;
introducing the methane and the carrier gas passed through the ortho-carborane precursor into the PECVD chamber to form a methane-ortho-carborane mixture;
applying radio frequency power within the PECVD chamber to the carrier gas-methane-ortho-carborane mixture to form one or more plasmas containing one or more species containing at least one of boron, carbon or hydrogen; and
depositing amorphous hydrogenated boron carbide to form a layer of an interconnect device structure of an electronic device, wherein the introduction of methane at a partial flow rate of 2.5 to 10% provides sufficient bond termination and network bridging to establish a carbon level between 10 and 20% by atomic weight, a dielectric constant (k), measured at 1×106 Hz, between approximately 2.5 and 2.7, a density between approximately 0.8 and 1.3 g/cm3, and a leakage current density (J) between 1×10?9 and 1×10?7 A/cm2, measured at 2 MV/cm, in the layer of the interconnect device structure;
wherein the temperature of the substrate is maintained between approximately 175 and 275° C. during the depositing of the amorphous hydrogenated boron carbide.
US Pat. No. 10,294,489

SOYBEAN RESISTANT TO CYST NEMATODES

BOARD OF TRUSTEES OF SOUT...

1. A transgenic soybean plant resistant to soybean cyst nematode (SCN), or a seed, plant part, or progeny thereof, the soybean plant transformed with an artificial DNA construct comprising, as operably associated components in the 5? to 3? direction of transcription:(a) a promoter that functions in a soybean plant;
(b) a transcribable nucleic acid molecule comprising
(i) a nucleotide sequence at least 99% identical to SEQ ID NO:3, wherein said nucleotide sequence comprises a C163225G mutation, and wherein said nucleotide sequence encodes a polypeptide having soluble NSF-attachment protein (SNAP) activity;
(ii) a nucleotide sequence encoding a polypeptide at least 99% identical to SEQ ID NO:6, wherein said polypeptide comprises a D208E mutation, and wherein said polypeptide has SNAP activity, or;
(iii) a nucleotide sequence which is the full length complement of (i) or (ii); and
(c) a transcriptional termination sequence;
wherein the promoter is heterologous to the transcribable nucleic acid molecule, and the transgenic soybean plant exhibits increased SCN resistance compared to a control transgenic soybean plant expressing SEQ ID NO:3.

US Pat. No. 10,202,406

BORON CLUSTER COMPOUNDS AND USES THEREOF

THE CURATORS OF THE UNIVE...

1. A method of treating acute pain in a subject in need of treatment, the method comprising administering to the subject a carborane substituted lidocaine selected fromor 2-(diethylamino)-N-(1,7-dimethyl-1,7-dicarba-closo-dodecaboran-9-yl)acetamide, wherein closed spheres represent a carbon atom bonded to a hydrogen atom, open spheres represent a boron atom bonded to a hydrogen atom, and hollow spheres represent a boron atom.
US Pat. No. 10,179,795

SYNTHESIS OF AMINE BORANES AND POLYHEDRAL BORANES

THE CURATORS OF THE UNIVE...

1. A method for synthesizing mixtures of salts of polyhedral boranes, comprising:combining a methyltriethylammonium halide with an alkali metal tetrahydroborate in a reaction mixture;
reacting the methyltriethylammonium halide and the alkali metal tetrahydroborate to form a methyltriethylammonium tetrahydroborate intermediate and an alkali metal halide; and
pyrolyzing the methyltriethylammonium tetrahydroborate intermediate to produce a product mixture comprising methyltriethylammonium decahydrodecaborate and methyltriethylammonium dodecahydrododecaborate.

US Pat. No. 10,490,679

FABRICATION OF MULTILAYER NANOGRATING STRUCTURES

The Curators of the Unive...

1. A method of manufacturing a nanoscale grating structure, comprising the steps of:spin-coating a mold in a solution of a polymer dissolved in a solvent;
curing the solution of the polymer in the mold to obtain a grating;
transferring the grating to a substrate;
applying a hydrophilicity treatment to the grating;
coating the treated grating in a fluorescence-enhancing reflective layer;
coating the fluorescence-enhancing reflective layer with a protective layer.

US Pat. No. 10,350,330

METHOD TO PRODUCE INORGANIC NANOMATERIALS AND COMPOSITIONS THEREOF

The Curators of the Unive...

1. A method for making nanoparticles, comprising:mixing a glass raw material with a nanoparticle base material to form a parent glass mixture; heating the parent glass mixture to a first temperature, forming a parent glass melt;
cooling the parent glass melt to a second temperature to solidify the parent glass melt, forming a parent glass;
heat or thermal treating the parent glass to form the nanoparticle base material into a plurality of nanoparticles suspended within the glass raw material, wherein contacting the glass raw material with the solvent or fluid releases the plurality of nanoparticles, and
contacting the parent glass with a body fluid, wherein the parent glass is reacted or degraded in vivo.

US Pat. No. 10,235,884

WIRELESS BEACON COLLISION WARNING SYSTEM

The Curators of the Unive...

1. A system for alerting a user of an impending collision, comprising:a first device comprising:
a first transmitter periodically transmitting a first 802.11 wireless network association beacon including position, speed, and direction information associated with the first device;
a second device comprising:
a first receiver operable to receive the first 802.11 wireless network association beacon;
one or more sensors operable to determine position, speed, and direction information associated with the second device;
a first processor;
one or more computer-readable media storing non-transitory computer-executable instructions that, when executed by the first processor, perform a method of alerting the user of the impending collision comprising the steps of:
determining that the second device has a lower time of closest approach to the first device than at least one other device;
processing, based on the time of closest approach, the position, speed, and direction information associated with the second device before information associated with the at least one other device;
determining, based on the position, speed, and direction information associated with the first device and the position, speed, and direction information associated with the second device, that a distance between the first device and the second device will be less than a predetermined threshold at a future time;
generating a first alert of the impending collision; and
presenting the first alert to the user.
US Pat. No. 10,213,447

PREPARATION OF ACETATE SALT COMPOSITIONS OF PHARMACEUTICAL AGENTS

The Curators of the Unive...

1. A process for improving the aqueous solubility of a material in a first aqueous solution wherein the material has a water solubility at a pH of about 6 to about 8 selected from the group consisting of about 1 mg/mL to about 500 ?g/mL, about 400 ?g/mL to about 300 ?g/mL, about 300 ?g/mL to about 200 ?g/mL, about 200 ?g/mL to about 100 ?g/mL to, about 100 ?g/mL to about 50 ?g/mL, about 50 ?g/mL to about 25 ?g/mL, about 25 ?g/mL to about 10 ?g/mL, and about 10 ?g/mL to about 1 ?g/mL, the process comprising:(a) forming a second aqueous mixture comprising nanoparticles of the material and one or more acetate salts selected from the group consisting of LiOAc, NaOAc, KOAc, and CsOAc, where the acetate salt is formed in situ from acetic acid and an added base containing an appropriate counter ion; and
(b) freeze drying the second aqueous mixture from (a) to yield nanoparticles of the material coated with a shell of the acetate salt wherein the material has improved aqueous solubility when the solid is mixed with the first aqueous solution.

US Pat. No. 10,180,118

ELECTRICAL/CHEMICAL THRUSTER USING THE SAME MONOPROPELLANT AND METHOD

The Curators of the Unive...

1. An electrical/chemical thruster for a spacecraft operable in a chemical mode and in an electrospray mode that utilizes a liquid monopropellant for operation in both of said chemical mode and said electrospray mode, said electrical/chemical thruster having a plurality of microthrusters, each microthruster of said plurality of microthrusters comprising a microtube having a bore therethrough and having an inlet end and an outlet end with each inlet end being in communication with a supply of said liquid monopropellant, each microtube comprising a catalytic material capable of being heated to a preheat temperature sufficient to decompose said liquid monopropellant as said liquid monopropellant flows therethrough at a first flowrate so as to generate relatively high thrust when operated in said chemical mode as compared to when operated in said electrospray mode, and wherein said electrical/chemical thruster further includes an extractor proximate each outlet end, whereby when said electrical/chemical thruster is operated in said electrospray mode with said extractor being energized to produce an electric field so that as said liquid monopropellant flows through each microtube at a second flowrate less than said first flowrate, ions and charged droplets discharged from each microtube are accelerated so as to yield a relatively high specific impulse as compared to operation of each microtube when operated in the chemical mode.

US Pat. No. 10,624,982

WOUND CARE COMPOSITIONS

The Curators of the Unive...


two or more alkali oxides selected from the group consisting of Li2O, Na2O, K2O, and Rb2O in a cumulative concentration between 5 and 25 wt %;
two or more alkaline earth oxides selected from the group consisting of MgO, SrO, BaO, and CaO in a cumulative concentration between 1 and 30 wt %;
wherein the glass-based particles comprise from 50 to 80 wt % B2O3, 1 to 25 wt % Na2O, 1 to 25% K2O, 1 to 40 wt % CaO, 1 to 25 wt % MgO, and 1 to 10 wt % P2O5;
and optionally one or more trace elements selected from the group consisting of Ag, Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn in a concentration between about 0.05 and 10 wt % per trace element chemically dissolved in the biocompatible material;
wherein the carrier is a biocompatible ointment or cream or a surgical glue.

US Pat. No. 10,542,911

SYSTEM AND METHOD FOR LARYNGEAL REFLEX EXAMINATION

The Curators of the Unive...

1. A system for delivering one or more pulses of pressure to the larynx of a subject to elicit a laryngeal adductor reflex (LAR) in the subject, the subject having a larynx comprising left and right vocal folds (VFs), said system comprising:a pressure pulsing component configured to provide an adjustable pulse of pressure to the larynx;
a respiratory sensor component configured to measure the respiratory cycle of the subject that is utilized to control operation of the pressure pulsing component;
a control system component in functional communication with the pressure pulsing component and the respiratory sensor, the control system configured to:
generate a respiratory waveform based on the respiratory cycle measurements received from the respiratory sensor by the respiratory sensor;
analyze the respiratory waveform to determine a start of an inspiration of the subject;
apply a system operator defined delay to the start of inspiration; and
trigger the pressure pulsing component to deliver a pulse of pressure at the end of the delay from the start of inspiration to control the timing of pulses of pressure delivered by the pressure pulsing component in one or more respiratory cycles.
US Pat. No. 10,421,783

PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) TARGETING PEPTIDES

The Curators of the Unive...

1. A peptide consisting of the amino acid sequence of SEQ ID NO: 2.
US Pat. No. 10,329,528

METHOD OF FORMING MICROPARTICLES FOR USE IN CELL SEEDING

The Curators of the Unive...

1. A method for forming microparticles useful for cell seeding comprising:obtaining an organic solution comprising poly(D,L-lactide-co-glycolide) (PLGA);
obtaining a first aqueous solution comprising polyvinyl alcohol (PVA);
obtaining a second aqueous solution comprising PVA in a higher concentration than said first aqueous solution;
co-injecting a stream of the organic solution and a carrier stream of the first aqueous solution into a flow focusing tube to form organic droplets within the carrier stream;
introducing the carrier stream comprising the organic droplets into the second aqueous solution to form microparticles of the PLGA in the second aqueous solution;
evaporating the organic solvent; and
removing the PVA, wherein the ratio of the PLGA to the organic solvent is from 5% (w/v) to 15% (w/v).

US Pat. No. 10,465,258

GRAIN REFINEMENT IN IRON-BASED MATERIALS

The Curators of the Unive...

1. A process for manufacturing an austenitic stainless steel comprising, in sequence:a) feeding iron-bearing material into a melting furnace and melting the iron-bearing material into molten metal;
b) introducing elements into the molten metal to react with dissolved oxygen and/or carbon in the molten metal to form targeted oxide and/or carbide dispersoids in the molten metal;
c) after said forming of the targeted oxide and/or carbide dispersoids in the molten metal, maintaining the molten metal at a temperature above a liquidus temperature of the molten metal and introducing one or more metal grain refiner elements into the molten metal to precipitate metal nitrides of the metal grain refiner elements to yield a molten metal containing the metal nitrides; and
d) cooling the molten metal containing said metal nitrides therein to a temperature below the solidus temperature of the molten metal to form solidified austenitic stainless steel.

US Pat. No. 10,330,673

FLUORESCENT CHEMICAL SENSOR FOR BIOLOGICAL AMINES

The Curators of the Unive...

1. A fluorescence sensing compound having the following formula:
wherein
Aryl is an unsubstituted or substituted aryl moiety, wherein the aryl moiety is selected from the group consisting of a monocyclic or polycyclic benzene-based moiety and, if the benzene-based moiety is polycyclic, the benzene-based moiety is homocyclic or heterocyclic, wherein the benzene-based moiety has the following formula:
wherein R3, R4, R5, and R6 are each independently selected from the group consisting of hydrogen, alkyl, alkylene, aryl, cycloalkyl, halo, hydroxyl, alkoxyl, aryloxy, alkylthio, arylthio, carboxyl, and alkoxycarbonyl, or one or more of R3, R4, R5, and R6, which are adjacent, are each a constituent of a fused unsubstituted or substituted aryl; andR1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkylene, aryl, and cycloalkyl.
US Pat. No. 10,159,735

PHOTOCLEAVABLE DRUG CONJUGATES

The Curators of the Unive...

1. A depot suitable for implantation into a patient comprising a photocleavable drug conjugate,said photocleavable drug conjugate comprising a plurality of drug molecules crosslinked to other drug molecules with a plurality of crosslinkers;
wherein the drug molecules are selected from the group consisting of insulin, its analogs, its derivatives and combinations thereof;
wherein the crosslinkers comprise crosslinkers having 2 to 5 photocleavable groups linked to a central bridging molecule;
wherein the conjugate does not comprise a polymer chain that functions as a backbone; and
wherein the ratio of the insulin to the crosslinkers is from 80:20 to 95:5 based on molecular weight.

US Pat. No. 10,689,260

SALT-ASSISTED ULTRASONIC DISAGGREGATION OF NANODIAMOND

The Curators of the Unive...

1. A method of disaggregating nanodiamond clusters, the method comprising:(a) combining aggregated nanodiamond clusters with a disaggregating agent in a liquid medium comprising a solvent, with the disaggregating agent being present in a concentration above its solubility limit in the solvent to form a mixture of solvent, disaggregating agent, and nanodiamond clusters; and
(b) sonicating the mixture for a time sufficient to produce nanodiamond particles having a median particle size less than the median particle size of the aggregated nanodiamond clusters,
wherein a mass ratio of disaggregating agent to nanodiamond particles in the liquid medium is from about 10:1 to about 100:1.

US Pat. No. 10,556,393

MONITORING OF CURE STATE THROUGH THE USE OF MICROWAVES

The Curators of the Unive...

1. A method of manufacturing a tire, comprising:curing the tire in a curing press;
applying microwave energy at a given frequency band into the tire during the curing of the tire;
monitoring the interaction between the microwave energy and the tire to obtain a complex reflection coefficient;
calculating a root-mean-squared error using the measured complex reflection coefficient and a reference reflection coefficient, wherein the reference reflection coefficient is from a fully cured tire made from the same material as the tire;
continuing to monitor the interaction to obtain the complex reflection coefficient and continuing to calculate the root-mean-squared error at different times during the curing of the tire in the curing press; and
using the calculated root-mean-squared errors to determine whether to stop the curing of the tire in the curing press.
US Pat. No. 10,329,576

METHOD TO DEVELOP HIGH OLEIC ACID SOYBEANS USING CONVENTIONAL SOYBEAN BREEDING TECHNIQUES

The Curators of the Unive...

1. A stably reproducing population of soybean seeds comprising a first polynucleotide sequence encoding a mutant FAD2-1A and a second polynucleotide sequence encoding a mutant FAD2-1B, whereinsaid first polynucleotide sequence is selected from the group consisting of (a) a polynucleotide sequence encoding a FAD2-1A mutant which includes at least one mutation comprising a non-conserved amino acid substitution of serine to asparagine at amino acid position 117 of SEQ ID NO: 10, and (b) a polynucleotide sequence encoding M23 mutant characterized by deletion of a FAD2-1A gene having the sequence as set forth in SEQ ID NO: 5, said FAD2-1A mutant is nonfunctional or has a reduced activity compared to wild-type FAD2-1A; and
said second nucleotide sequence is selected from the group consisting of (a) a polynucleotide sequence encoding a FAD2-1B mutant which includes at least one mutation comprising a non-conserved amino acid substitution of proline to a polar amino acid selected from the group consisting of arginine, glycine, serine, threonine, cysteine, asparagine, tyrosine, glutamine, lysine and histidine at amino acid position 137 of SEQ ID NO: 12, and (b) a polynucleotide sequence encoding a FAD2-1B mutant which includes at least one mutation comprising a non-conserved amino acid substitution of isoleucine to a polar amino acid selected from the group consisting of arginine, glycine, serine, threonine, cysteine, asparagine, tyrosine, glutamine, lysine and histidine at amino acid position 143 of SEQ ID NO: 12, said FAD2-1B mutant is nonfunctional or has reduced activity compared to wild-type FAD2-1B,
wherein oil from said population of soybean seeds has about 65% to about 85% oleic acid content.

US Pat. No. 10,238,772

BIODEGRADABLE COMPOSITE SCAFFOLD FOR REPAIRING DEFECTS IN LOAD-BEARING BONES

The Curators of the Unive...

1. A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, including load-bearing bone tissue, the scaffold comprising:a core consisting of biocompatible, biodegradable inorganic glass fibers; and
only a biocompatible, biodegradable, flexible polymer film surrounding the core and adhered to the core;
wherein the core with surrounding polymer film is characterized by a flexural strength of at least about 40 MPa; and
wherein the core is characterized by open and interconnected porosity to facilitate fluid flow into and lengthwise within the scaffold.

US Pat. No. 10,980,130

METAL FOILS WITH ORDERED CRYSTAL STRUCTURE AND METHOD FOR PRODUCING METAL FOILS

THE CURATORS OF THE UNIVE...

1. A method for producing a metal foil comprising:depositing metal onto an oxidizable substrate comprising single crystal Si to form a metal film on the substrate;
oxidizing the substrate at an interface between the metal film and the substrate; and
removing the metal film from the substrate to yield a metal foil.

US Pat. No. 10,759,774

INHIBITORS OF HEPATITIS B VIRUS TARGETING CAPSID ASSEMBLY

THE CURATORS OF THE UNIVE...

1. A composition comprising a compound of formula:

US Pat. No. 10,706,983

MASS PRODUCTION METHOD OF LOADING RADIOISOTOPES INTO RADIOVOLTAICS

The Curators of the Unive...

1. A method of producing an integrated circuit-type active radioisotope battery, the method comprising exposing at least a portion of an electronically functional, unactivated integrated circuit-type battery that is either on a substrate or comprises the substrate, wherein the unactivated integrated circuit-type battery comprises an unactivated cell that comprises:a conversion device for converting energy from decay products of a radioisotope into electrical energy capable of performing work; and
a non-radioactive, transmutable material associated with the conversion device, wherein the transmutable material is located in one or more of the following: a layer in contact with the conversion device; the substrate; and the conversion device;to radiation to transmute at least a portion of the transmutable material to a radioisotope thereby producing an active cell, wherein the energy from the decay products of the radioisotope material are converted by the conversion device into electrical energy capable of performing work, thereby producing the integrated circuit-type active radioisotope battery.

US Pat. No. 10,548,319

COMPOSITIONS AND METHODS FOR SYNTHETIC AMPHIPHILE-INDUCED CHANGES IN PLANT ROOT MORPHOLOGY

The Curators of the Unive...

1. A method for increasing the lateral root density of a plant, the method comprising treating one or more plants with a composition comprising a lariat ether amide with the structure of formula III:
wherein n is 4 to 20, and
wherein the increase in the lateral root density of the plant is in comparison to the average lateral root density of a statistically significant control population of plants that has not been treated with the lariat ether amide.

US Pat. No. 10,451,479

MULTICHANNEL ULTRA-SENSITIVE OPTICAL SPECTROSCOPIC DETECTION

The Curators of the Unive...

1. A system, comprising:a reflective grating configured to angularly resolve a collimated light beam and permit selection of a reference wavelength from a wavelength region in which optical absorption of a sample is negligible, wherein the reference wavelength corresponds to a reference voltage for use by a differential voltage analyzer;
an optical device coupled to the reflective grating and configured to receive and focus the angularly resolved light beam;
a multichannel array detector configured to receive the focused light beam and output signals representative of a plurality of wavelength components of the light beam;
a low-noise preamplifier coupled to the multichannel array detector and configured to convert the signals outputted by the multichannel array detector into independent voltage signals, wherein the independent voltage signals correspond to a cancellation coefficient and a proportional constant; and
a differential voltage analyzer coupled to the low-noise preamplifier and configured to generate a differential voltage signal representative of each of the wavelength components relative to a noise reduction reference value, wherein the differential voltage signal is based on the independent voltage signals, the reference voltage, the cancellation coefficient, and the proportional constant.
US Pat. No. 10,273,522

RAPID DETECTION OF VIABLE BACTERIA SYSTEM AND METHOD

The Curators of the Unive...

1. A system to detect viable organisms in a fluid sample, the system comprising:a sample collection system containing a growth medium to receive the fluid sample;
a channel to receive a portion of the fluid sample from the collection system; and
a detection system in communication with the channel to measure a bulk capacitance of the portion of the fluid sample received in the channel, where the bulk capacitance corresponds to a concentration of the viable organisms within the fluid sample; wherein the detection system generates a plurality of analysis frequencies from 1 kHz up to and including 100 Mhz.

US Pat. No. 10,259,158

METHOD AND APPARATUS FOR FABRICATING CERAMIC AND METAL COMPONENTS VIA ADDITIVE MANUFACTURING WITH UNIFORM LAYERED RADIATION DRYING

The Curators of the Unive...

1. A multilayered extrusion fabrication process for producing three-dimensional ceramic and metal objects, comprising:a) preparing an aqueous paste;
b) extruding the aqueous paste onto a target surface in an oil tank to define an extruded layer having a top surface and at least one side surface;
c) filling the oil tank with sufficient oil to submerge the at least one side surface of the extruded layer in oil;
d) uniformly drying the extruded layer with an application of thermal energy through the top surface remove moisture contained therein; and
e) repeating steps b) through d) to define a green body made of a plurality of stacked, dried layers.