US Pat. No. 9,309,208

METHODS OF MAKING AND USING THIOXOTHIAZOLIDINE AND RHODANINE DERIVATIVES AS HIV-1 AND JSP-1 INHIBITORS

Southern Methodist Univer...

1. A thioxothiazolidin compound of formula (I):

wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halo, alkyl, aryl, hydroxyl, alkoxyl, aryloxyl, aralkoxyl,
cyano, nitro, alkylcarbamido, arylcarbamido, dialkylcarbamido, diarylcarbamido, alkylarylcarbamido, alkylthiocarbamido, arylthiocarbamido,
dialkylthiocarbamido, diarylthiocarbamido, alkylarylthiocarbamidb, amino, alkylamino, arylamino, dialkylamino, diarylamino,
arylalkylamino, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, dialkylaminocarbonyl, diarylaminocarbonyl, arylalkylamino-carbonyl,
alkylcarbonyloxy, arylcarbonyloxy, carboxyl, alkoxycarbonyl, aryloxycarbonyl, sulfo, alkylsulfonylamido, arylsulfonylamido,
alkylsulfonyl, arylsulfonyl, alkylsulfinyl, arylsulfinyl and heteroaryl.

US Pat. No. 9,171,251

CONTEXT-AWARE ANALYSIS AND ADAPTATION

TOYOTA JIDOSHA KABUSHIKI ...

1. A computer-implemented method for providing multi-dimensional context-aware adaptation in vehicular networks, the method
comprising:
collecting context data describing a context in a communication environment;
resolving the context data to a matching historical context;
determining one or more historical context groups associated with the matching historical context;
determining a subset of operating parameters from the one or more historical context groups;
distributing the subset of operating parameters to a network stack communication module;
measuring a network performance for the subset of operating parameters;
classifying the network performance, the context data, and the subset of operating parameters to form a context group;
determining that the context group is a distinct context group; and
responsive to the determination that the context group is distinct, storing the distinct context group including the context
data, data describing the network performance and the subset of operating parameters.

US Pat. No. 9,110,089

SYSTEM AND METHOD FOR PREDICTING A FORCE APPLIED TO A SURFACE BY A BODY DURING A MOVEMENT

Southern Methodist Univer...

1. A system comprising:
at least one memory; and
at least one processor operable to:
receive data of a body during a movement from a component that captures the data of the body during the movement;
convert, based at least on a conversion rule, the data of the body during the movement to a position or motion of one or more
points of the body during the movement;

based at least on the position or motion of the one or more points of the body during the movement:
calculate, using a first calculation rule, a first one or more curves indicative of a first force, wherein the first calculation
rule is based on previously measured data; and

calculate, using a second calculation rule, a second one or more curves indicative of a second force, wherein the second calculation
rule is based on previously measured data; and

predict a force applied to a surface by the body during the movement based at least on the first and second one or more curves.

US Pat. No. 9,362,876

LOOK-UP TABLE DIGITAL PREDISTORTION TECHNIQUE FOR HIGH-VOLTAGE POWER AMPLIFIERS IN ULTRASONIC APPLICATIONS

Southern Methodist Univer...

1. A digital controller for use with an ultrasound power amplifier circuit to increase linearity and efficiency of the ultrasound
power amplifier circuit, wherein the digital controller comprises:
a digital signal generator that has a first output and a second output;
a digital to analog converter that has an output coupled to an input of the ultrasound power amplifier circuit and an input
coupled to the first output of the digital signal generator;

a memory unit that has a first input coupled to the second output of the digital signal generator, an output coupled to the
input of the digital to analog converter, and the memory unit comprises a processor and a look-up table;

a delay adjustment block coupled to the input of the digital to analog converter;
a feedback circuit that has a first input comprising an analog to digital converter coupled to an output of the ultrasound
power amplifier circuit, a second input coupled to the delay adjustment block, and an output coupled to a second input of
the memory unit; and

the processor obtains an output signal from the ultrasound power amplifier circuit through the feedback circuit and an ideal
output signal from the digital signal generator that is delayed based on the delay adjustment block, and repeatedly operates
in a calibration mode followed by an evaluation mode, wherein the processor: (i) calculates a value of error based on a difference
between the delayed ideal output signal and the output signal obtained from the ultrasound power amplifier circuit, and stores
the value of error in the look-up table in the calibration mode, and (ii) equalizes an input signal from the digital signal
generator to reduce nonlinearity in the output signal of the ultrasound power amplifier circuit using the value of error stored
in the look-up table in the evaluation mode.

US Pat. No. 9,131,223

ENHANCING IMAGING PERFORMANCE THROUGH THE USE OF ACTIVE ILLUMINATION

Southern Methodist Univer...

1. A system comprising:
an illumination system operable to project a first illumination pattern having a first spatial periodicity and a second illumination
pattern having a second spatial periodicity onto an object, and each of the first illumination pattern and the second illumination
pattern comprise a superposition of sinusoids;

an imaging system having a position spatially disposed from a projector, the imaging system operable to capture a plurality
of images;

the plurality of images including a first image of an object acquired under the first illumination pattern in a first orientation,
wherein the image of the illuminated object is comprised of low frequency Moiré fringes encoding spatial frequencies inaccessible
to imaging optics of the imaging system;

the plurality of images including a second image of the object acquired under the second illumination pattern in a second
orientation, wherein the observed pattern exhibits phase deformations that encode object topography;

the first spatial periodicities oriented based on the position of the illumination system relative to the imaging system;
the second spatial periodicities oriented based on the position of the illumination system relative to the imaging system
and based on an orientation of the first spatial periodicities; and

a processor, the processor operable to:
based on the low frequency Moiré fringes, construct an image of the object whose resolution exceeds the resolving power of
the imaging system; and

based on the phase deformations, construct a depth map of the object.

US Pat. No. 9,684,489

SQUARING CIRCUIT

Southern Methodist Univer...

1. An apparatus comprising:
a squaring circuit configured to:
identify a fixed-point value with a fixed word size and a substring size for substrings of the fixed-point value, wherein
the fixed-point value comprises a string of digits and an initial operand;

for an initial iteration, determine a square of least significant digits of the initial operand;
for each subsequent iteration:
determine an operand for that iteration by decatenating least significant digits from an operand in a previous iteration,
wherein a length of the least significant digits from the operand of the previous iteration is equal to the substring size;
and

determine a square using the least significant digits of the operand for that iteration and the substring size; and
concatenate the squares from each iteration to estimate a square of the fixed-point value.

US Pat. No. 9,282,993

STEERABLE EXTENDABLE DEVICES

SOUTHERN METHODIST UNIVER...

1. An elongatable, steerable apparatus capable of growing from a proximal end to a distal end through a process of assembly
wherein one or more segments are added to the distal end of the apparatus, the apparatus comprising:
a first segment having a lumen therethrough, the first segment having a proximal end and a distal end;
a segment transporter that delivers one or more additional segments to the first segment through the lumen of the first and
any subsequent segment; and

a second segment having a lumen, a proximal end, and a distal end, wherein the second segment is attached to the distal end
of the first segment by the segment transporter, and wherein the second segment is capable of changing a growth direction
of the distal end of the apparatus and of one or more subsequent segments.

US Pat. No. 9,811,690

PROTECTING HIDDEN CONTENT IN INTEGRATED CIRCUITS

Southern Methodist Univer...

1. An integrated circuit comprising:
one or more hidden content;
a first segment insertion bit circuit connected to at least one of the one or more hidden content;
a second segment insertion bit circuit connected to the first segment insertion bit circuit;
the first segment insertion bit circuit and the second segment insertion bit circuit form all or part of a serial data path;
the first segment insertion bit circuit provides access to the at least one of the one or more hidden content whenever the
first segment insertion bit circuit is in a first specified state and prevents access to the at least one of the one or more
hidden content whenever the first segment insertion bit scan cell circuit is in a different state than the first specified
state;

the first segment insertion bit circuit does not interrupt the serial data path when the first segment insertion bit circuit
in the first specified state or the different state;

whenever the second insertion bit circuit changes to a second specified state, the second segment insertion bit circuit changes
an operational characteristic of the first segment insertion bit circuit by one or more of: (a) disabling the first segment
insertion bit circuit, (b) causing a delay in changing the first segment insertion bit circuit to the first specified state,
the different state, or both the first specified state and the different state, (c) causing the first segment insertion bit
circuit or another circuit connected to the first segment insertion bit circuit or another circuit within the serial data
path to operate at a slower scan shift frequency, (d) introducing a required change in a shift path voltage of the first segment
insertion bit circuit or another circuit connected to the first segment insertion bit circuit or another circuit within the
serial data path, or (e) automatically changing the first segment insertion bit circuit to the different state if the first
segment insertion bit circuit is in the first specified state or preventing the first segment insertion bit circuit from being
in the first specified state whenever one or more conditions are detected;

the second insertion bit circuit does not interrupt the serial data path when the second segment insertion bit is in any state;
and

the first segment insertion bit circuit or the second segment insertion bit circuit requires clocking of a correct update
value in an update cell and a correct key value in each of one or more key bits to change the segment insertion bit circuit
to: (a) the first specified state, the different state, or both the first specified state and the different state with respect
to the first segment insertion bit circuit, or (b) the second specified state, the different state, or both the second specified
state and the different state with respect to the second segment insertion bit circuit.

US Pat. No. 9,243,006

MULTI-THIOL MERCAPTOALKOXYSILANE COMPOSITIONS

Southern Methodist Univer...

1. A mercaptoalkoxysilane composition comprising the formula:
wherein at least one of the R2, R3, and R4 groups are independently an alkoxy having the formula —O(CH2)nSH, an alkyl, an aryl, or derivatives thereof wherein n is an integer between 1 and 30.

US Pat. No. 9,108,711

GENERATION OF A PULSED JET BY JET VECTORING THROUGH A NOZZLE WITH MULTIPLE OUTLETS

SOUTHERN METHODIST UNIVER...

18. A system for vectored jet thrust comprising:
a vehicle having an outer surface, wherein two or more vectored jet thrusters are mounted within the vehicle, each of the
two or more vectored jet thrusters comprising:

a jet of substantially constant flow whose downstream trajectory is vectored at one or more angles with respect to an axis
of an upstream portion of the jet;

two or more fluid conduits in fluid communication with the jet; and
one or more outlets in fluid communication with the fluid conduits, the one or more outlets positioned on the outer surface
of the vehicle and configured to exhaust at the outer surface of the vehicle, wherein a fluid flow through the conduits is
transiently varied by alternately vectoring the jet to the conduits fluidically, mechanically, or electromagnetically, wherein
exhaust from the one or more outlets is transient while the jet is substantially constant;

wherein jet exhaust from the two or more vectored jet thrusters causes the vehicle to move in at least one of straight cruise,
horizontal/vertical translation, and rotation about the pitch, yaw, or roll axes.

US Pat. No. 9,493,452

COMPOUNDS AND DERIVATIVES OF 2H-PYRIDO (3,2-B)(1, 4) OXAZIN 3)4H)-ONES AS RAF KINASE AND LRRK2 INHIBITORS

Southern Methodist Univer...

1. A pharmaceutical composition of formula:
wherein R3, R5, R7, R8, and R10 are independently a hydrogen or a halogen in a pharmaceutical carrier to inhibit raf Kinase,
LRRK2 or both.

US Pat. No. 9,447,124

MULTI-THIOL MERCAPTOALKOXYSILANE COMPOSITIONS

Southern Methodist Univer...

1. The mercaptoalkoxysilane composition having the formula:

US Pat. No. 9,476,755

CALIBRATION TUBE FOR MULTIPHASE FLOWMETERS

Southern Methodist Univer...

1. An automated calibration device for a multiphase flowmeter, wherein the calibration device is placed vertically and comprises:
a tube for holding a liquid multiphase sample, wherein the tube comprises two or more valves for trapping the multiphase sample;
a temperature sensor;
a pressure sensor; and
three ultrasound transducer pairs positioned at one or more specific locations in or around the tube, wherein the three transducer
pairs comprise:

a bottom/transversal (BT) pair at the bottom of the tube that is positioned to measure a liquid phase of the multiphase sample;
a top/transversal (TT) pair at the top of the tube that is positioned to measure a gas phase of the multiphase sample; and
a longitudinal (LTLB) pair that is positioned transverse to the BT and TT pairs and that measures across the gas phase and
the liquid phase of the multiphase sample.

US Pat. No. 9,963,362

METHOD FOR ELECTROCHEMICAL BROMIDE AND/OR CHLORIDE REMOVAL

Southern Methodist Univer...

1. A method for the oxidation of ions in an aqueous electrolyte solution by an electrochemical technique comprising the steps of:providing a treatment chamber comprising at least one electrochemical cell to contain an aqueous electrolyte solution and an inlet and an outlet, wherein the aqueous electrolyte solution comprises 20-200 ppm bromide ions, 20-200 ppm chloride ions or a mixture of 20-200 ppm bromide ions and 20-200 ppm chloride ions;
at least one anode in the treatment chamber; and
at least one cathode in the treatment chamber;
a pH adjusting mechanism connected to the treatment chamber comprising an acid reservoir for holding an acid and supplying the acid to the treatment chamber to maintain the pH between 0.1 to 2.0;
a pH monitor in communication with the treatment chamber to determine the pH of the aqueous electrolyte solution;
a bromine detector in communication with the treatment chamber to detect bromine in the aqueous electrolyte solution;
an aqueous electrolyte solution flow controller in communication with the treatment chamber and the inlet, the outlet or both to control the flow of the aqueous electrolyte solution into the treatment chamber; and
a control unit in communication with
the aqueous electrolyte solution flow controller to control the flow of the electrolyte solution,
the at least one anode to control the oxidization reaction,
the at least one cathode to control the reduction reaction,
the bromine detector to determine the bromine concentration,
the pH monitor to determine the pH, and
the acid reservoir to control the pH and to oxidize bromide to bromine;
connecting a power supply to the control unit to supply power to the at least one anode and the at least one cathode to generate an electric current sufficient to generate bromine, chlorine, or a combination thereof and reduce bromate formation in the aqueous electrolyte solution;
providing an electrolyte reservoir for holding the aqueous electrolyte solution connected to the inlet and the aqueous electrolyte solution flow controller;
adjusting the aqueous electrolyte solution flow controller to flow a selected volume of the electrolyte solution between the electrolyte reservoir and the electrochemical cell;
adjusting the pH of the aqueous electrolyte solution to between 0.1 to 2.0 with the pH adjusting mechanism by adding the acid from the acid reservoir to the aqueous electrolyte solution;
adjusting the power supply to provide an electrical current between 0.01 to 5.0×105 A and a voltage between 0.1 to 1000 V sufficient to generate bromine, chlorine or a combination thereof in the aqueous electrolyte solution;
oxidizing bromide ions to bromine, chloride ions to chlorine, or both, through oxidation at the one or more anodes or oxidizing bromide ions to bromine indirectly through generating electrochemically generated intermediate oxidants that oxidize bromide ions to bromine, chloride ions to chlorine, or both;
determining the amount of bromine produced using the bromine detector;
adjusting a bromide ion concentration to between 20-100 ppm;
generating chlorine at the at least one anode;
adjusting the chloride ion concentration to between 62 and 125 ppm;
determining a SO4?2 concentration;
adjusting the SO4?2 concentration to between 700-2000 ppm; and
generating peroxodisulfate at the at least one anode.

US Pat. No. 9,818,000

PROTECTING HIDDEN CONTENT IN INTEGRATED CIRCUITS

Southern Methodist Univer...

1. An integrated circuit comprising:
a first scan cell segment;
a second scan cell segment connected to one or more hidden content;
a segment insertion bit circuit connected to the first scan cell segment and the second scan cell segment, wherein the segment
insertion bit circuit forms all or part of a serial data path, provides access to the first scan cell segment and prevents
access to the second scan cell segment whenever a state of the segment insertion bit circuit is a first specified state, provides
access to the second scan cell segment and prevents access to the first scan cell segment whenever the state of the segment
insertion bit circuit is in a second specified state, and the segment insertion bit circuit requires clocking of a correct
update value in an update cell and a correct key value in each of one or more key bits to change the state of the segment
insertion bit circuit;

wherein the segment insertion bit circuit automatically switches to provide access to the first scan cell segment or prevents
the state of the segment insertion bit circuit from being changed whenever one or more conditions are detected; and

wherein the one or more conditions comprise a circuit reset, a specified data from a real time clock, a specified time period
since the segment insertion bit circuit was changed to the first specified state, a specified number of clock cycles since
the first segment insertion bit circuit was changed to the first specified state, a specified number of shift cycles since
the segment insertion bit circuit was changed to the first specified state, a specified number of shift-update cycles since
the segment insertion bit circuit was changed to the first specified state, a specified number of capture cycles since the
segment insertion bit circuit was changed to the first specified state, a specified number or set of shift signal toggles,
a specified number of capture signal toggles, a specified number of update signal toggles, a data read or produced by an embedded
instrument, a specified data obtained from a geographic location signal, a data obtained from a wireless connection, a data
obtained from one or more inputs of the integrated circuit, or a combination thereof.

US Pat. No. 9,561,227

INHIBITORS OF MULTIDRUG RESISTANCE TRANSPORTER P-GLYCOPROTEIN

Southern Methodist Univer...

1. A method of treating a subject having prostate cancer or liver cancer that is resistant to one or more chemotherapeutic
drugs comprising the steps of:
identifying a subject having one or more drug resistant prostate or liver cancer cells that express a P-glycoprotein;
administering to the subject a pharmaceutically effective amount of an inhibitor compound having the following structural
formula:

and
contacting one or more drug resistant cancer cells with the inhibitor compound to reduce the drug resistance of the prostate
or liver cancer cells.

US Pat. No. 9,329,699

METHOD FOR SUBJECT CLASSIFICATION USING A PATTERN RECOGNITION INPUT DEVICE

SOUTHERN METHODIST UNIVER...

1. A method for classifying a user using pattern recognition of an input device comprising the steps of:
providing an input device having a user input interface, one or more sensors, a processor and a memory, wherein (a) a keystroke
object is created whenever a single user input is received by the user input interface, and (b) the keystroke object includes
three or more key attributes comprising (1) a vector of variable length representing pressure data measured by the one or
more sensors during entry of the single user input, (2) timing data measured by the one or more sensors during entry of the
single user input, and (3) a unique symbol, function or command associated with the single user input;

receiving a series of the keystroke objects via the user input interface;
determining a typing signature for the series of keystroke objects using the processor by analyzing the three or more key
attributes for each keystroke object within the series of keystroke objects using a pattern recognition algorithm;

comparing the typing signature to one or more user typing signatures stored in the memory using the processor, wherein each
stored user typing signature includes a user specific inconsistency/consistency factor for each of the key attributes of the
series of keystroke objects that either permits or penalizes a variability in the each of the key attributes of the stored
typing signature; and

classifying the user based on whether or not the typing signature is statistically similar to one of the stored user typing
signature, and updating the stored user typing signature for the user whenever the typing signature is statistically similar
to the stored user typing signature of the user.

US Pat. No. 10,093,681

COMPOUNDS AND DERIVATIVES OF 2H-PYRIDO (3,2-B)(1, 4) OXAZIN 3)4H)-ONES AS RAF KINASE AND LRRK2 INHIBITORS

Southern Methodist Univer...

1. A compound selected from 3-(3,5-dibromo-4-hydroxybenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 3-(3,5-dibromobenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 3-(3,5-dibromo-4-hydroxybenzylidene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; 3-(3,4,5-trimethoxybenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 4-chloro-3-(3,5-dibromobenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-3-(1H-pyrrol-2-yl)methylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-3-(1H-pyrrol-2-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; 4-chloro-3-(3,4,5-trimethoxybenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 3-(3,4,5-trimethoxybenzylidene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; 3-(4-(dimethylamino)benzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 4-chloro-3-(4-(dimethylamino)benzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 3-(4-(dimethylamino)benzylidene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; (Z)-3-(1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; (Z)-3-(1H-indol-3-yl)methylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-3-(1H-indol-3-yl)methylene)-4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-3-(thiophen-2-ylmethylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; (Z)-3-(thiophen-2-ylmethylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-4-chloro-3-(thiophen-2-ylmethylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; and (E)-3-(furan-2-ylmethylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one.

US Pat. No. 9,913,146

USING GEOGRAPHICAL FEATURES TO REDUCE IN-FIELD PROPAGATION EXPERIMENTATION

Southern Methodist Univer...

1. An apparatus for determining cell coverage in a region with reduced in-field propagation measurements comprising:
a cell phone or equivalent device comprising a code segment that obtains wireless signal strength and global positioning system
coordinates;

a data base that comprises geographical features of the region; and
a processor that comprises a non-transitory computer readable medium, comprising instructions stored thereon, that when executed
by a computer having a communications interface, one or more databases and one or more processors communicably coupled to
the interface and one or more databases, perform the steps comprising:

predicting a number of measurements required to accurately characterize a path loss in the region by obtaining RSSI readings
in terms of dBm, wherein the measurements are obtained when an API reports RSSI in terms of Arbitrary Strength Units (ASU),
which quantizes obtained RSSI values in the equation:

Prx(dBm)=2*Prx(ASU)?113  (1)

Prx(ASU)=[0,31]  (2)

to determine relative path loss accuracy;
oversampling a suburban and a downtown region from cell measurements that comprise signal strength and global positioning
system coordinates to determine the path loss prediction accuracy of wardriving and crowdsourcing; and

using a statistical learning framework to build a relationship between the geographical features and the measurements, thereby
reducing the number of measurements needed to determine path loss accuracy.

US Pat. No. 9,567,305

QUINOXALINE COMPOUNDS AND DERIVATIVES

Southern Methodist Univer...

1. A compound or pharmaceutical salts thereof, wherein the compound has the formula:

US Pat. No. 10,254,499

ADDITIVE MANUFACTURING OF ACTIVE DEVICES USING DIELECTRIC, CONDUCTIVE AND MAGNETIC MATERIALS

Southern Methodist Univer...

1. A method for segmenting and feeding a fiber comprising:providing a continuous fiber;
providing a capillary having a lumen;
advancing the fiber through the lumen in a downstream direction;
locally damaging the fiber in a region upstream of the capillary;
advancing the fiber downstream until the damaged region is inside the capillary;
clamping the fiber inside the capillary at a location downstream of the damaged region so the fiber cannot move;
applying tension to the fiber upstream of the capillary to break the fiber in the damaged region and yield a downstream wire segment;
releasing the downstream wire segment within the capillary so the downstream wire segment can be advanced;
advancing the downstream wire segment by pushing the downstream wire segment with the fiber upstream of the segment,
wherein a fiber segment of the desired length is delivered by the capillary.

US Pat. No. 10,336,006

METHODS AND APPARATUS FOR ADDITIVE MANUFACTURING

Southern Methodist Univer...

1. A method for additive manufacturing of a composite article comprising:forming a three-dimensional mesh comprising a plurality of fibers by:
alternately inserting a first subset of the plurality of fibers along the X-axis between a third subset of the plurality of fibers along the Z-axis followed by inserting a second subset of the plurality of fibers along the Y-axis between the third subset of the plurality of fibers along the Z-axis to form a layer, fibers in each subset separated by gaps which form voids between the plurality of fibers;
introducing a flowable, solidifiable material into the layer; and
solidifying the material;
wherein the material at least partially surrounds the fibers and wherein portions of the material are solidified to form a solid matrix embedding the fibers.

US Pat. No. 10,292,982

INHIBITORS OF MULTIDRUG RESISTANCE TRANSPORTER P-GLYCOPROTEIN

Southern Methodist Univer...

1. A method of treating a subject having cancer that is resistant to one or more chemotherapeutic drugs comprising the steps of:identifying a subject having one or more drug resistant prostate cancer cells that express a P-glycoprotein;
administering to the subject a pharmaceutically effective amount of an inhibitor compound having one of the following structural formulas:

contacting the one or more drug resistant prostate cancer cells with the inhibitor compound to reduce the drug resistance of the cancer cells.

US Pat. No. 10,172,855

INHIBITORS OF MULTIDRUG RESISTANCE TRANSPORTER P-GLYCOPROTEIN

Southern Methodist Univer...

1. A method of treating a subject having cancer that is resistant to one or more chemotherapeutic drugs comprising the steps of:identifying a subject having one or more drug resistant cancer cells that express a P-glycoprotein, wherein the cancer cells are prostate cancer cells, or liver cancer cells;
administering to the subject a pharmaceutically effective amount of an inhibitor compound having one of the following structural formula:
andcontacting one or more drug resistant cancer cells with the inhibitor compound to reduce the drug resistance of the cancer cells.

US Pat. No. 10,371,898

ENHANCED COUPLING STRENGTH GRATING HAVING A COVER LAYER

Southern Methodist Univer...

1. A grating, comprising:a substrate;
a core disposed on the substrate, wherein the core has an index of refraction (ncore);
one or more ridges and one or more grooves formed on the core, wherein the one or more grooves are adjacent to, or between the one or more ridges, wherein the ridges and grooves form a grating;
a liner layer disposed on at least a portion of a grating cycle, wherein the liner layer has a liner thickness of between 5 and 50 nm and an index of refraction (nliner);
an amorphous or crystalline cover layer disposed on the liner layer, wherein the cover layer has a cover thickness of between 100 and 300 nm, and an index of refraction (ncover);
a superstrate or air layer disposed above the cover layer;
wherein a first material selected for the core and ridges and a second material selected for the liner layer are selected to provide a first difference in the index of refraction between the first material (ncore) and second material (nliner) that is sufficient to provide a contrast therebetween; and
wherein a third material is selected for the amorphous or crystalline cover layer to provide a second difference in the index of refraction between the second material (nliner) and the third material (ncover), and the third material is not the same as the first material.