US Pat. No. 9,526,161

HIGH-FREQUENCY POWER SUPPLY DEVICE

SHIMADZU CORPORATION, Ky...

1. A high-frequency power supply device of a self-oscillating method, the device comprising:
a DC power supply;
an LC resonant circuit including an induction coil for plasma generation, and a capacitor;
a switching circuit including a semiconductor device that switches DC power supplied from the DC power supply, and provides
high-frequency power to the LC resonant circuit; and

a transformer including a primary coil that is included in the LC resonant circuit, and a secondary coil that is connected
to a control terminal of the semiconductor device to turn on or off the semiconductor device,

wherein the transformer is formed into a substantially U shape,
wherein the primary coil and the secondary coil of the transformer are arranged in parallel, and
wherein a capacitor is connected to the control terminal of the semiconductor device, in parallel with the secondary coil.

US Pat. No. 9,214,489

PHOTODIODE AND METHOD FOR PRODUCING THE SAME, PHOTODIODE ARRAY, SPECTROPHOTOMETER AND SOLID-STATE IMAGING DEVICE

National University Corpo...

1. A photodiode, comprising:
a first-conduction-type region in a semiconductor layer made of silicon;
an insulator layer being in contact with the semiconductor layer; and
a second-conduction-type region located between the first-conduction-type layer and an interface between the semiconductor
layer and the insulator layer, the second-conduction-type region having a polarity opposite to the first-conduction-type region,

wherein a thickness of a non-depleted region of the second-conduction-type region is larger than roughness of the interface
between the semiconductor layer and the insulator layer in a region having a length of 1 ?m in a direction parallel to the
interface, and is smaller than a penetration depth of ultraviolet light at which an intensity of the ultraviolet light in
a wavelength range of 200-320 nm entering the semiconductor layer is equal to 1/e times the intensity of the same ultraviolet
light at an outermost surface of the silicon.

US Pat. No. 9,429,471

PHOTODIODE ARRAY FOR SPECTROMETRIC MEASUREMENTS AND SPECTROMETRIC MEASUREMENT SYSTEM

SHIMADZU CORPORATION, Ky...

1. A photodiode array for spectrometric measurements having a plurality of photodiodes arrayed in a one-dimensional form,
the photodiode array being arranged so that an array direction of the photodiodes is made to coincide with a wavelength-dispersing
direction of a light-dispersing element so as to concurrently detect wavelength components of light dispersed by the light-dispersing
element, wherein:
the photodiodes are divided into groups in such a manner that each group includes one or more photodiodes neighboring each
other in the array direction, with at least one group including two or more photodiodes; and

the groups are covered with an antireflection coating having a common transmittance characteristic for each group, and being
composed of a material different from a neighboring group or having a thickness different from a neighboring group.

US Pat. No. 9,420,210

SOLID-STATE IMAGE SENSOR FOR CAPTURING HIGH-SPEED PHENOMENA AND DRIVE METHOD FOR THE SAME

TOHOKU UNIVERSITY, Miyag...

1. A solid-state image sensor, comprising:
a pixel area in which a plurality of pixels each including a photoelectric conversion section for receiving light and producing
photocharges are arranged in a two-dimensional array; and

a memory area, which is an area separated from the pixel area and in which a burst reading memory section and continuous reading
memory section are arranged for each pixel,

the burst reading memory section having memory sections such that each pixel is connected to its own plurality of memory sections
in the burst reading memory section, the plurality of the memory sections being provided to hold output signals of one pixel
in the pixel area for a plurality of frames without being read to an outside of the memory area, and

separately from the burst reading memory section, the continuous reading memory section having memory sections such that each
pixel is connected to its own one memory section in the continuous reading memory section, and

in which an output signal line for reading signals held in the burst reading memory section and an output signal line for
reading a signal held in the continuous reading memory section are independently provided.

US Pat. No. 9,086,397

AUTOMATIC SAMPLER

SHIMADZU CORPORATION, Ky...

1. An automatic sampler comprising:
a sample container placing portion for placing a sample container containing a sample therein;
a sample suction mechanism for suctioning the sample from the sample container placed in the sample container placing portion;
a weight sensor fixed to the sample container placing portion, for measuring a weight of the sample container placed in the
sample container placing portion;

a sample suction amount setting part for setting an amount of sample to be suctioned from the sample container by the sample
suction mechanism;

a controller for controlling the sample suction mechanism in such a manner that the sample suction mechanism suctions the
sample from the sample container by the amount set in the sample suction amount setting part;

a sample amount calculating part for determining an amount of sample in the sample container placed in the sample container
placing portion based on a measurement value detected by the weight sensor; and

a sample suction amount calculating part for determining an amount of sample actually suctioned from the sample container
based on a change in the amount of sample contained in the sample container, determined by the sample amount calculating part
before and after a sample suction by the sample suction mechanism,

wherein the sample suction amount setting part includes an additional suction amount setting part for an amount equal to a
shortage as an additional suction amount in the case where the sample suction amount determined by the sample suction amount
calculating part is short by a predetermined amount or more with respect to the amount set in the sample suction amount setting
part, and

wherein the controller is configured to control the sample suction mechanism in such a manner that the sample suction mechanism
further suctions the sample from the sample container by the additional suction amount set in the additional suction amount
setting part,

and the automatic sampler further comprising a display configured to display an injection report including at least the amount
of sample to be suctioned set in the sample suction amount setting part and an actual sample suction amount including the
additional suction amount.

US Pat. No. 9,311,695

IMAGE PROCESSING METHOD AND RADIOGRAPHIC APPARATUS USING THE SAME

SHIMADZU CORPORATION, Ky...

1. An image processing method for image processing a radiographic image with a subject falling thereon, comprising the steps
of:
generating a first band image through high-pass filter processing to a source image having an image of a subject falling thereon;
generating a reduction image by reducing a size of the source image;
performing low-pass filter processing to the reduction image to generate a low-pass image;
magnifying the low-pass image to generate a magnified low-pass image;
generating a second band image by subtracting the first band image and the magnified low-pass image from the source image;
generating a third band image through performing of band-pass fitter processing to the reduction image; and
performing image processing to the source image with each of the band images.

US Pat. No. 9,250,219

COLUMN OVEN FOR LIQUID CHROMATOGRAPH

SHIMADZU CORPORATION, Ky...

1. A column oven for a liquid chromatograph, comprising:
a temperature control mechanism possessing a heater, the temperature control mechanism controlling a temperature by the heater;
and

a thermally conductive column holding member for holding an analytical column of a liquid chromatograph and for transferring
heat from the temperature control mechanism to the analytical column,

the column holding member being arranged in contact with the temperature control mechanism,
the column holding member including a space for containing the analytical column, the space being formed to have an opening
on one lateral side surface of the column holding member and to have a cross-sectional shape forming a part of an involute
curve along a vertical direction with respect to a longitudinal direction of the analytical column held in the column holding
member,

wherein the cross-sectional shape of the column holding member has a recess that is curved to below a lower end of the opening
and reaches an upper end of the opening after drawing the part of the involute curve, and

wherein a distance from the center of the involute curve to a wall surface on a cross-section of the space gradually decreases
from the upper end of the opening toward the lower end of the opening.

US Pat. No. 9,239,298

OPTICAL MEASUREMENT PROBE, AND OPTICAL MEASUREMENT DEVICE PROVIDED WITH THE SAME

SHIMADZU CORPORATION, Ky...

1. An optical measurement probe structured to guide light generated in a high temperature environment to an appliance, comprising:
an optical window for transmitting light incident on an incidence surface; and
a light guide for guiding light which has passed through the optical window to the appliance,
wherein the incident surface of the optical window is covered by a deposited protective film which is formed from a lipophobic
material and which protects the window from greasy dirt.

US Pat. No. 9,074,926

ELECTRONIC BALANCE WITH WINDPROOF CASE AND ELECTRICALLY CONDUCTIVE STRUCTURE

SHIMADZU CORPORATION, Ky...

1. An electronic balance in which a metal lower case and a resin upper case are attached, said electronic balance comprising
a load detection part for detecting the load of an object to be weighed and
a windproof case provided on a main body case,
wherein the object to be weighed is placed on a scale pan inside the windproof case so as to measure the weight thereof, and
said electronic balance is equipped with a metal tube structure constituting a rear wall of said windproof case and an electrically
conductive structure disposed under the tube structure for electrically connecting said tube structure and said lower case,
and

wherein the tube structure houses a substrate for performing measurements.

US Pat. No. 9,453,846

MASS SPECTROMETRY METHOD USING MATRIX

SHIMADZU CORPORATION, Ky...

1. A mass spectrometry method using, as a matrix, a 2,4,6-trihydroxyalkylphenone represented by the following general formula
(I):

where R is an alkyl group having 4 to 12 carbon atoms.

US Pat. No. 9,171,706

MASS ANALYSIS DEVICE AND MASS ANALYSIS METHOD

SHIMADZU CORPORATION, Ky...

1. A mass analysis device, comprising:
an ion trap which temporarily captures ions derived from a target compound which is the object of analysis, and promotes the
dissociation of the captured ions;

a gas supply which introduces cooling gas, for cooling the ions captured in the internal space of said ion trap, into said
ion trap;

an analysis execution unit which executes, on the same sample, multiple mass analyses with different gas pressure conditions
in said ion trap created by the gas supplied into the ion trap by said gas supply; and

a precursor ion selection unit which, by comparing the signal intensities of peaks of the same mass/charge ratio for the multiple
mass spectra acquired under the aforementioned different gas pressure conditions, distinguishes multiple ions having the same
basic structure and differing in the number of modifiers bonded to said basic structure, and selects at least one of those
ions as a precursor ion.

US Pat. No. 9,295,734

BRANCHED AMPHIPATHIC BLOCK POLYMER AND MOLECULAR AGGREGATE AND DRUG DELIVERY SYSTEM USING SAME

SHIMADZU CORPORATION, Ky...

1. A branched-type amphiphilic block polymer comprising:
a branched hydrophilic block comprising sarcosine; and
a hydrophobic block comprising polylactic acid;
wherein the branched-type amphiphilic block polymer has a structure represented by the following formula (I):

wherein n1, n2 and n3 represent numbers whose sum is 3 to 200, m represents a number of 15 to 60, and R represents a hydrogen
atom or an organic group.

US Pat. No. 9,470,280

IRREVERSIBLE MECHANISM

SHIMADZU CORPORATION, Ky...

1. An irreversible mechanism comprising:
an input shaft that receives input of rotational drive force;
an output shaft that receives transmission of torque from the input shaft;
a ball ramp part including a first plate on the output shaft, a second plate facing the first plate, and a ball that is placed
between a first ball ramp of the first plate and a second ball ramp of the second plate, the ball ramp part generating radial
force when load torque is applied to the output shaft and the first plate rotates relative to the second plate;

a brake lining that receives the radial force from the ball ramp part through the second plate;
a brake drum that the brake lining is pressed against when the brake lining receives the radial force from the ball ramp part;
and

a housing that accommodates the input shaft, the output shaft, the ball ramp part, the brake lining, the brake drum and an
energizing means inside.

US Pat. No. 9,431,226

HIGH-VOLTAGE POWER UNIT AND MASS SPECTROMETER USING THE POWER UNIT

SHIMADZU CORPORATION, Ky...

1. A high-voltage power unit, comprising, for selectively outputting a high voltage of positive or negative polarity:
a positive voltage generating circuit for generating a positive high voltage;
a negative voltage generating circuit for generating a negative high voltage; and
a control circuit for controlling each of the positive high voltage generated by the positive voltage generating circuit and
the negative high voltage generated by the negative voltage generating circuit, wherein

one of a pair of output terminals of the positive voltage generating circuit is connected to one of a pair of output terminals
of the negative voltage generating circuit to connect the two voltage generating circuits in a series connection, and

one of two terminals of the series connection is used as a reference side, while the other terminal is used to take out a
high-voltage output whose polarity is switched,

the high-voltage power unit further comprising:
a) a first impedance-variable circuit section connected between the pair of output terminals of the positive voltage generating
circuit;

b) a second impedance-variable circuit section connected between the pair of output terminals of the negative voltage generating
circuit;

c) a first output driver for driving the second impedance variable circuit section to change an impedance of the second impedance-variable
circuit section based on a voltage or a current appearing at the pair of output terminals of the positive voltage generating
circuit; and

d) a second output driver for driving the first impedance-variable circuit section to change an impedance of the first impedance-variable
circuit section based on a voltage or a current appearing at the pair of output terminals of the negative voltage generating
circuit.

US Pat. No. 9,389,239

LIQUID-SAMPLE COLLECTING SYSTEM AND LIQUID-SAMPLE COLLECTING METHOD

SHIMADZU CORPORATION, Ky...

1. A liquid-sample collecting system, comprising:
a sampling needle to be inserted into a sample container through a septum for collecting a liquid sample contained in the
sample container;

a driver for vertically moving the sampling needle;
an input unit for allowing a user to enter a kind of liquid sample to be collected for setting a first ascent speed of the
sampling needle;

an ascent-speed determiner for determining the first ascent speed based on the kind of liquid sample entered by the user;
a switch for selecting the first ascent speed or a second ascent speed, the second ascent speed being equal to a predetermined
descent speed; and

a controller for controlling the driver so as to move the sampling needle downward at the predetermined descent speed in a
descent phase, and upward unidirectionally at the first ascent speed or the second ascent speed, which is selected through
the switch, in an ascent phase,

wherein the ascent-speed determiner has a previously created data table in which kinds of liquid samples to be collected are
related to optimal ascent speeds, and sets the optimal ascent speed as the first ascent speed by referring to the data table
upon receiving the kind of liquid sample entered through the input unit by the user, the optimal ascent speed being determined
so as to detach the liquid-sample from an outer wall of the sampling needle while a tip of the sampling needle is immersed
in the liquid sample contained in the sample container, and the optimal ascent speed being slower than the predetermined descent
speed, and

wherein the data table is a table for relating the kinds of liquid samples to the ascent speeds of the sampling needle taking
into account a characteristic of a viscosity and/or density of the liquid samples.

US Pat. No. 9,188,238

FLOW CHANNEL SWITCHING VALVE

SHIMADZU CORPORATION, Ky...

1. A flow channel switching valve, comprising:
a housing that has a plurality of connection ports connecting flow channel piping, and an internal space, and is provided
with a flow channel connection portion as a plane projected from a periphery thereof, the flow channel connection portion
being a region where holes of end portions of flow channels respectively leading to the connection ports are arranged in a
flow channel connection plane, which is one plane of the internal space;

a stator that is contained inside the housing, is made of a flat plate-like member having a plane larger than the flow channel
connection portion, and is fixed to a side of the flow channel connection plane of the housing;

a packing that is made of a flat plate-like member having a plane larger than the flow channel connection portion, and is
sandwiched between the flow channel connection plane of the housing and the stator so that a central portion of one plane
thereof tightly adheres to the flow channel connection portion;

a rotor that has a plane in contact with a plane of the stator on an opposing side of the packing inside the internal space
of the housing, and is formed with a groove communicating between any one pair of the connection ports in the plane;

a rotor drive portion that rotates the rotor while sliding the rotor on the stator; and
a packing gland that is provided at a distance from the flow channel connection portion so as to surround an outer circumference
of the flow channel connection portion in the flow channel connection plane of the housing, and is in contact with a circumferential
edge portion of the packing on a same plane as the flow channel connection portion.

US Pat. No. 9,045,097

TWO-DIMENSIONAL POSITION MAP CORRECTING METHOD

SHIMADZU CORPORATION, Ky...

1. A two-dimensional position map correcting method used when detecting radiation with radiation detectors each formed of
a plurality of scintillator elements arranged in one dimension, two dimensions or three dimensions, and a light sensor optically
coupled thereto, for preparing a look-up table from a two-dimensional position map presenting, in two dimensions, signal strengths
obtained with the light sensor as corresponding to incident positions of the radiation incident on the scintillator elements,
the two-dimensional position map correcting method comprising:
a histogram preparing step for acquiring a histogram by preparing the histogram with a vertical axis representing signal strengths
of the two-dimensional position map and with a horizontal axis being in a coordinate axis direction of the two-dimensional
position map; and

a map determining step for applying a map determination condition using amounts of characteristic extracted from grid shapes
delimited vertically and horizontally on the two-dimensional position map, to areas delimited by delimiting points based on
the histogram acquired in the histogram preparing step, the map determining step being repeated until the map determination
condition is satisfied, by changing the areas delimited by the delimiting points,

wherein the map determining step is repeated by applying the map determination condition to the areas delimited by the delimiting
points, and changing the areas delimited by the delimiting points in the order of large total of the signal strengths until
the map determination condition is satisfied.

US Pat. No. 9,391,593

CIRCUIT FOR GENERATING A VOLTAGE WAVEFORM

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer including:
a circuit for generating a voltage waveform at an output node; and
a load capacitance to which the output node of the circuit is connected so that, in use, the load capacitance receives a voltage
waveform generated by the circuit; wherein the circuit includes:

a first voltage rail connected to the output node via a first voltage rail switch;
a second voltage rail connected to the output node via second voltage rail switch;
an anchor node connected to the output node via an inductor and a bidirectional switch, wherein the bidirectional switch includes
two or more transistors connected in series; and

a control unit configured to change the voltage at the output node by controlling the first voltage rail switch, the second
voltage rail switch, and the bidirectional switch so that a resonant circuit is established between the inductor and the load
capacitance;

wherein the control unit of the circuit is configured to control the circuit to operate according to a control method including:
opening the bidirectional switch and closing the first voltage rail switch so that the output node is clamped at a voltage
of the first voltage rail;

causing the voltage at the output node to swing towards the voltage of the second voltage rail by opening the first voltage
rail switch and closing the bidirectional switch so that a resonant circuit is established between the inductor and the load
capacitance;

opening the bidirectional switch and closing the second voltage rail switch so that the output node is clamped at a voltage
of the second voltage rail; and

causing the voltage at the output node to swing towards the voltage of the first voltage rail by opening the second voltage
rail switch and closing the bidirectional switch so that a resonant circuit is established between the inductor and the load
capacitance; and

wherein the control unit is configured to change a frequency at which the switching voltage waveform switches between the
voltage of the first voltage rail and the voltage of the second voltage rail.

US Pat. No. 9,373,490

TIME-OF-FLIGHT MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. Orthogonal acceleration-type time-of-flight mass spectrometer, comprising:
a) an orthogonal acceleration portion that accelerates ions introduced therein in a direction orthogonal to the optical axis
of the ion beam;

b) a repeller electrode provided parallel to the optical axis of the ion beam;
c) an extraction electrode provided opposite said repeller electrode across from the ion beam, which serves as a grid electrode;
d) a plurality of ring or cylindrical acceleration electrodes that together form the acceleration field that serves to accelerate
ions traversing the grid of said extraction electrodes in a direction orthogonal to the optical axis of the aforesaid ion
beam by means of the electric field formed between the aforesaid repeller electrode and the aforesaid extraction electrode;
and

e) a voltage input portion that, towards the aim of producing focusing action on the ions in a direction orthogonal to the
direction of acceleration, inputs to each of the aforesaid plurality of acceleration electrodes a voltage determined to form,
over at least a portion of the aforesaid acceleration field, an electric field in which the declining gradient of the potential
distribution along the central axis of the aforesaid plurality of acceleration electrodes increases gradually in the direction
of progress of the ions.

US Pat. No. 9,360,462

GAS CHROMATOGRAPH MASS SPECTROMETER

SHIMADZU CORPORATION, To...

1. A method of replacing a septum or glass insert of a gas chromatograph mass spectrometer, the gas chromatograph mass spectrometer
comprising:
an oven for gas chromatography provided with a housing, a column disposed inside said housing, and a first heater for heating
said housing;

a sample vaporization chamber provided with a casing having a sample introduction port through which a liquid sample is introduced,
a carrier gas introduction port through which a carrier gas is introduced, and a column connection port connected to the inlet
end of said column and a second heater for heating said casing;

a mass spectrometry part which is connected to the outlet end of said column and has a detector for detecting an ion intensity
signal of said liquid sample;

a gas supplying part for supplying a carrier gas to the carrier gas introduction port of said sample vaporization chamber;
and

a control part having an input device for inputting setting content including an analysis temperature;
wherein said septum into which the needle of a syringe containing a liquid sample is inserted is disposed in said sample introduction
port, said glass insert is disposed for vaporizing the liquid sample inside said casing, and said control part obtains an
ion intensity signal from said detector while controlling the first heater, the second heater, and the gas supplying part
based on the setting content inputted by said input part;

the method comprising:
receiving an input signal to said input device corresponding to starting a replacement operation for replacement of said septum
or glass insert;

in response to said input signal, said control part controls the gas supplying part so that the flow rate of said carrier
gas has a constant pressure and controls the heaters so that the temperature is equal to or less than a temperature at which
replacement is possible; and

when the temperature becomes equal to or less than the temperature at which replacement is possible and the replacement operation
of said septum or glass insert is completed, said control part obtains an ion intensity signal from said detector, calculates
the intensity of the mass spectrum of nitrogen based on the ion intensity signal and based on the intensity of the mass spectrum
of nitrogen determines to control the heaters so that the temperature becomes an analysis temperature, and then controls the
gas supplying part to employ the same control method for the flow rate of said carrier gas as that before the replacement
operation is begun

wherein said control part calculates an intensity ratio of the mass spectrum of a first ion with respect to a mass spectrum
of a second ion, and determines to control the heaters so that the temperature becomes an analysis temperature when the intensity
ratio is less than a threshold corresponding to a state in which there is not a prescribed amount of oxygen inside said column.

US Pat. No. 9,342,903

METHOD FOR GENERATING IMAGE FOR PET ATTENUATION CORRECTION FROM MR IMAGE AND COMPUTER PROGRAM

NATIONAL INSTITUTE OF RAD...

1. A method for generating an image for PET attenuation correction from an MR image, comprising:
segmenting an MR image captured by MRI into regions according to pixel values,
determining a radiation attenuation correction value in a region in which a radiation attenuation coefficient is considered
to be uniform by referring to an existing radiation attenuation correction value table, and

determining a radiation attenuation correction value in a region including multiple tissues having different radiation attenuation
coefficients by referring to a standard image.

US Pat. No. 9,303,239

METHOD FOR CLEANING MICROFLUIDIC DEVICE AND CLEANING LIQUID

SHIMADZU CORPORATION, Ky...

1. A method for cleaning a microfluidic device, said method comprising:
cleaning a channel that is formed in the microfluidic device by bringing the channel into contact with a cleaning liquid comprised
only of an organic solvent having solubility in at least the same volume of water at 25° C., or a cleaning liquid containing
50 vol % or more of the organic solvent in a buffer solution,

wherein the channel (1) has a surface having a silanol group thereon and a polymer coating covalently bonded to the surface,
and (2) has been brought into contact with a sample containing nucleic acid and/or protein as an object to be analyzed and
an impurity other than the object to be analyzed.

US Pat. No. 9,198,267

DEUTERIUM LAMP POWER SUPPLY CIRCUIT

SHIMADZU CORPORATION, Ky...

1. A deuterium lamp power supply circuit comprising:
a) a capacitor for applying a voltage between a positive electrode of a deuterium lamp and a negative electrode of the deuterium
lamp, with one terminal of the capacitor being connected to the positive electrode;

b) a power supply, installed between the capacitor and the negative electrode, for charging the capacitor; and
c) a two-terminal switch connected in parallel to the power supply.

US Pat. No. 9,306,108

RADIATION DETECTOR

SHIMADZU CORPORATION, Ky...

1. A radiation detector for detecting radiation, comprising:
a conversion film, having a first surface and a second surface opposite to the first surface, for converting radiation incident
on the first surface into an electric charge;

a plurality of first strip electrodes elongated in a first direction and arranged in parallel with each other on the second
surface of the conversion film; and

a plurality of second strip electrodes elongated in a second direction intersecting the first direction and arranged in parallel
with each other on the first surface of the conversion film,

the conversion film including a sensitive semiconductor film and joining semiconductor films,
the sensitive semiconductor film being sensitive to the incident radiation to generate the electric charge, and
the joining semiconductor films being formed respectively on surfaces of the sensitive semiconductor film, the surfaces of
the sensitive semiconductor film being on the sides of the first and second surfaces, respectively, the joining semiconductor
films each covering at least an entire sensitive region in the corresponding surface of the sensitive semiconductor film,
each having a resistance value higher than resistance value of the sensitive semiconductor film, and achieving suppressed
movement of the electric charge generated in the sensitive semiconductor film in directions in which the first strip electrodes
and the second strip electrodes are arranged when the electric charge passes through the joining semiconductor films.

US Pat. No. 9,261,448

PARTICLE SIZE DISTRIBUTION MEASURING APPARATUS

SHIMADZU CORPORATION, Ky...

1. A particle size distribution measuring apparatus, comprising:
a light source for emitting light for measurement;
a detector for detecting the light intensity distribution;
a sample cell placing portion for placing a sample cell in which a sample including particles to be measured is contained
along a light path between the light source and the detector;

a light intensity distribution obtaining unit for obtaining the light intensity distribution that occurs when the sample is
irradiated with the light for measurement from said light source through detection by the detector; and

a particle size distribution calculating unit for calculating the particle size distribution of the particles to be measured
included in said sample by using the light intensity distribution obtained by said light intensity distribution obtaining
unit, characterized by further comprising:

a temperature adjusting member for adjusting the temperature of said sample cell, wherein
said temperature adjusting member is movable between a first location along the light path around said sample cell and a second
location that is outside the light path, and

said temperature adjusting member is moved to the second location when the sample is irradiated with the light for measurement
from said light source.

US Pat. No. 9,460,903

GLYCOPEPTIDE ANALYZER

SHIMADZU CORPORATION, Ky...

1. A glycopeptide analyzer for performing an analysis on a glycoform mixture of a glycoprotein or glycopeptide, comprising:
a) an ion-trap mass spectrometer section having an ion trap capable of temporarily capturing ions generated from a sample
and fragmenting the captured ions, the ion-trap mass spectrometer section being configured to separate the ions according
to their mass to charge ratios by the ion trap or another mass separator and to detect the separated ions;

b) a time-of-flight mass spectrometer section for introducing ions generated from a sample into a flight space, for separating
the ions according to their mass-to-charge ratios within the flight space, and for detecting the separated ions;

c) a glycopeptide detector section for detecting peaks related to dissociation of a portion or the entirety of glycan on a
first MS1 spectrum created based on a result of a measurement by the ion-trap mass spectrometer section, for detecting molecular ion
peaks on a second MS1 spectrum created based on a result of a measurement by the time-of-flight mass spectrometer section, and for finding glycopeptide
ions from common peaks located on both MS1 spectra;

d) a quantitative analyzer section for determining, for the glycopeptide ion detected by the glycopeptide detector section,
a relative quantity of a glycoform using a relative peak intensity on the second MS2 spectrum; and

e) a structural analyzer section for performing, for the glycopeptide ion detected by the glycopeptide detector section, a
structural analysis of a glycoform using, at least, the result of an MSn analysis (where n is an integer equal to or greater than two) performed by the ion-trap mass spectrometer section.

US Pat. No. 9,373,487

MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer having one or more ion transport optical systems for transporting ions by an effect of an electric
field between an ion source and an ion detector, the mass spectrometer being capable of performing an SIM or MRM measurement
in which an operation of sequentially performing a mass spectrometry on each of a plurality of ions having previously specified
mass-to-charge ratios is cyclically performed, and the mass spectrometer comprising:
a) a voltage generator for applying a direct-current voltage corresponding to the mass-to-charge of an ion to be monitored,
to at least one of the ion transport optical systems in the SIM or MRM measurement; and

b) a controller for controlling the voltage generator so that, in a pause time during which collection of detection data by
the ion detector is suspended in conjunction with a switching of the mass-to-charge ratio of the ion to be monitored, if a
polarity of the ion to be monitored in an SIM or MRM measurement is unchanged before and after the switching of the mass-to-charge
ratio, then the direct-current voltage applied to the at least one ion transport optical system, while being switched from
one specific level to another specific level in the pause time, is temporarily changed to either a level at which the direct-current
voltage has a polarity different from the polarity of the direct-current voltage at those specific levels, or a level at which
the direct-current voltage has the same polarity as the direct-current voltage at those specific levels yet has a smaller
absolute value than the direct-current voltage at any of those specific levels.

US Pat. No. 9,285,381

ANALYZING APPARATUS CONTROL SYSTEM AND PROGRAM FOR CHROMATOGRAPH MEASUREMENTS

SHIMADZU CORPORATION, Ky...

1. An analyzing apparatus control system for controlling an analyzing apparatus so as to temporally separate a sample to be
examined by a chromatograph, and repeat unit measurements in each of one or more measurement time ranges set in a total measurement
time, where a unit measurement includes one or more measurements carried out under predetermined conditions, the analyzing
apparatus control system comprising:
a) a time range displayer for displaying time ranges, in each of which each of one or more measurements is carried out under
predetermined conditions and displayed as a range bar; and

b) a loop time displayer for computing a loop time, which is a summation of times of all measurements included in the unit
measurement and times for operations, for each of the measurement time ranges and displaying results of computations.

US Pat. No. 9,081,105

RADIATION DETECTOR

SHIMADZU CORPORATION, Ky...

1. A radiation detector comprising:
a scintillator, wherein scintillator crystals for converting radiation into the fluorescence are arranged in the crosswise
and lengthwise directions of the scintillator, and wherein a first, second, third and fourth layer are arranged in the height
direction of the scintillator; and

a plurality of reflecting plates that extend in the crosswise direction or the lengthwise direction, for reflecting the fluorescence,
in the gaps between mutually adjacent scintillator crystals, wherein:

reflecting plates that extend in the crosswise direction are arranged in the lengthwise direction with spacing equal to the
size of one scintillator crystal so as to alternate between the first layer and the second layer of the scintillator,

reflecting plates that extend in the lengthwise direction are arranged spanning the first layer and the second layer of the
scintillator and with spacing equal to the size of two scintillator crystals in the crosswise direction, and

the reflecting plates that extend in the crosswise direction and the reflecting plates that extend in the lengthwise direction
are fitted together to structure a reflecting plate lattice that has the same height as two layers of the scintillator.

US Pat. No. 9,364,188

X-RAY APPARATUS FOR ROUND VISIT

SHIMADZU CORPORATION, Ky...

1. An X-ray apparatus for round visit comprising:
an X-ray emitting device for emitting X-rays;
a movable carriage having the X-ray emitting device;
a lever handle attached to the movable carriage;
traveling drive wheels for moving the movable carriage;
motors for driving the traveling drive wheels;
a motor control device for controlling the motors based on travel controls detected with the lever handle;
a brake lever attached to the movable carriage;
brakes for stopping the movable carriage by mechanical braking; and
a brake control device for controlling the brakes based on a brake operation detected with the brake lever, wherein
the brake control device includes a deceleration control device for carrying out deceleration control of the movable carriage
when a brake operation is carried out at the brake lever; and

the brake control device is arranged to stop the movable carriage by driving the brakes after the movable carriage is decelerated
by the deceleration control.

US Pat. No. 9,202,663

FLAT FILAMENT FOR AN X-RAY TUBE, AND AN X-RAY TUBE

SHIMADZU CORPORATION, Ky...

1. A flat filament for an X-ray tube, comprising:
a first electron emission surface;
a first current supply leg connected to a first end region of the first electron emission surface;
a second current supply leg connected to a second end region opposite from the first end region of the first electron emission
surface;

a second electron emission surface disposed laterally of the first electron emission surface and connected to the first end
region of the first electron emission surface;

a third current supply leg connected to a second end region of the second electron emission surface;
a third electron emission surface disposed laterally of the first electron emission surface, opposite from the second electron
emission surface, and connected to the second end region of the first electron emission surface; and

a fourth current supply leg connected to a first end region of the third electron emission surface, wherein
the first, second, third, and fourth current supply legs have current supplied from a heating current supply source, and
the heating current supply source supplies the current directly to the first, second, third, and fourth current supply legs,
respectively.

US Pat. No. 9,360,466

SAMPLE INTRODUCTION MECHANISM FOR TOTAL ORGANIC CARBON METER

SHIMADZU CORPORATION, Ky...

1. A sample introduction mechanism configured to be used with a total organic carbon meter, the sample introduction mechanism
comprising:
a sample introduction rod comprising a sample tray for placing a sample thereon arranged at a front end part of the sample
introduction rod;

a case configured to be connected to one end of a combustion tube of a combustion furnace, wherein a sample introduction rod
opening is formed in the case;

wherein the sample introduction rod is configured to be inserted through the sample introduction rod opening such that the
sample tray is moved by the sample introduction rod in a set direction from one end of the combustion tube toward another
end, and the sample tray is thereby arranged inside a central part of the combustion tube whereby organic material inside
the sample combusts;

a cover formed on an outer circumferential surface of the sample introduction rod; and
an elastic member mounted on the sample introduction rod which urges the cover to move in the set direction in relation to
the sample introduction rod;

wherein the elastic member is coupled to the sample introduction rod such that insertion of the sample introduction rod through
the sample introduction rod opening causes a gap between the sample introduction rod opening and said sample introduction
rod to be closed by the cover.

US Pat. No. 9,285,043

FLOW CHANNEL SWITCHING VALVE

SHIMADZU CORPORATION, Ky...

1. A flow channel switching valve comprising:
a housing that has an internal space, the housing including a housing top having a plurality of connection ports connecting
flow channel piping in an outer surface thereof, and having, on a side of the internal space, a flow channel connection portion
where connection holes respectively leading to the connection ports are arranged on one plane, and a housing body detachably
holding the housing top;

a stator having through-holes corresponding to the connection holes of the flow channel connection portion, respectively,
and attached to a side of the housing top while keeping liquid tightness to the flow channel connection portion in a state
where the through-holes are positioned at the connection holes;

a rotor that has a plane in contact with a surface of the stator on an opposing side of the flow channel connection portion,
and is provided with a groove in the plane, the groove forming a flow channel selectively connecting between any one pair
of the through-holes of the stator;

a rotor drive portion that rotates the rotor while sliding the rotor on the stator; and
a stator fixing member that has a portion detachably mounted on the housing top from a side of the stator, and a portion holding
the stator, and fixes the stator to the housing top,

wherein the stator fixing member is a cylindrical member surrounding an outer circumference of the stator,
wherein an engagement portion that is engaged with a circumferential edge portion of a surface of the stator on a side of
the rotor is provided at one end of the stator fixing member as the portion holding the stator,

wherein the portion detachably mounted on the housing top is another end of the stator fixing member, and is configured so
as to be mounted on the housing top, and

wherein an circular groove into which the other end of the stator fixing member is fitted is formed around the flow channel
connection portion of the housing top.

US Pat. No. 9,274,030

SAMPLE INTRODUCTION DEVICE INCLUDING CHANNEL SWITCHING MECHANISM

SHIMADZU CORPORATION, Ky...

1. A sample introduction device, comprising:
a sample channel in which a sample tube wherein a sample has been captured is arranged;
a sample tube temperature regulation mechanism which performs heating and cooling of said sample tube;
a trap channel comprising a trap column for capturing sample desorbed from said sample tube;
a trap temperature regulation mechanism which performs heating and cooling of said trap column;
a sample introduction channel whereof one end is connected to an analysis channel comprising an analytical column for performing
separation of samples and a detector for detecting sample components separated in the analytical column;

a splitter which is arranged upstream of said analytical column in said sample introduction channel and which has a first
and second split outlets which split and feed out the supplied gas, wherein the first split outlet is connected to said analytical
column;

a first carrier gas supply channel which supplies carrier gas for transporting the sample from said sample tube to said trap
column;

a second carrier gas supply channel which supplies carrier gas for transporting the sample captured in said trap column to
said analysis channel simultaneously with or at a different timing from said first carrier gas supply channel; and

a channel switching mechanism which allows switching between a trap capture state in which said sample channel and said trap
channel are connected from the upstream side to downstream of said first carrier gas supply channel and said sample introduction
channel is connected to downstream of said second carrier gas supply channel, and a sample introduction and recapture state
in which said trap channel and said sample introduction channel are connected from the upstream side to downstream of said
second carrier gas supply channel and said sample channel is connected to the second split outlet of said splitter.

US Pat. No. 9,230,788

MASS SPECTROGRAPH APPARATUS AND METHOD OF DRIVING ION GUIDE

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer comprising an ion guide in which 2n (where n is an integer equal to or larger than 3) rod-like or plate-like
electrodes extending along an ion optical axis are arranged so as to surround the ion optical axis, the mass spectrometer
further comprising:
a) voltage generating means for generating a first radio-frequency voltage and a second radio-frequency voltage having a same
amplitude as and an inverted phase from the first radio-frequency voltage, as voltages for forming a radio-frequency electric
field in a space surrounded by the respective electrodes of the ion guide; and

b) electrical connecting means for electrically connecting the voltage generating means and the respective electrodes of the
ion guide such that the first radio-frequency voltage is applied to m (where m is an integer equal to or larger than 2 and
equal to or less than 2n?1) electrodes adjacent to each other around the ion optical axis among the 2n electrodes constituting
the ion guide, and the second radio-frequency voltage is applied to at least one of the other 2n?m electrodes;

the arrangement of the respective electrodes being rotationally symmetrical about the ion optical axis.

US Pat. No. 9,396,923

ION SELECTION METHOD IN ION TRAP AND ION TRAP SYSTEM

SHIMADZU CORPORATION, Ky...

1. An ion selection method for selecting an ion having a specific mass-to-charge ratio or an ion group having a specific range
of mass-to-charge ratios from among ions captured in an ion trap composed of three or more electrodes, the method comprising:
a) a low-mass side ion isolation step, in which unnecessary ions having mass-to-charge ratios lower than the specific mass-to-charge
ratio or the specific range of mass-to-charge ratios to be selected are removed by performing, on the ions captured in the
ion trap, an ion-discharging operation in which a portion of the ions are discharged by shifting a position of a working line
on a stability diagram based on a Mathieu equation and thereby changing a lower limit mass that can be captured; and

b) a high-mass side ion isolation step, in which unnecessary ions having mass-to-charge ratios higher than the specific mass-to-charge
ratio or the specific range of mass-to-charge ratios to be selected are removed by performing, on the ions captured in the
ion trap, an ion-discharging operation in which a portion of the ions are discharged by using a resonant excitation,

where the two steps are performed in this order, in a reverse order or simultaneously.

US Pat. No. 9,314,794

NEEDLE PORT

Shimadzu Corporation, Ky...

1. A needle port system comprising:
an in-port path; anda needle for inserting into the in-port path, the needle having a tapered portion on an end of a body and a path inside the
body through which a liquid passes,
wherein the in-port path comprises:
a) a guide section having an inside diameter which is larger than an outside diameter of the body of the needle;
b) a passage section having an inside diameter which is smaller than the outside diameter of the body of the needle and larger
than a tip diameter of the tapered portion of the needle; and

c) a tapered section for connecting the guide section and the passage section, the tapered section having a taper angle which
is larger than a taper angle of the tapered portion of the needle and half a difference between a largest inside diameter
and a smallest inside diameter of the tapered section is smaller than half a difference between the outside diameter of the
body of the needle and the tip diameter.

US Pat. No. 9,275,843

TIME-OF-FLIGHT MASS SPECTROMETER

Shimadzu Corporation, Ky...

1. An orthogonal acceleration time-of-flight mass spectrometer comprising:
an orthogonal acceleration unit for accelerating incident ions in a direction orthogonal to an incident axis of the ions;
and

an ion-injecting optical system for sending the ions into the orthogonal acceleration unit, wherein the ion-injecting optical
system comprises:

an electrostatic lens composed of five or more cylindrical electrodes arranged along an ion-optical axis;
a voltage supplier for applying voltages to the respective cylindrical electrodes so that the electrostatic lens becomes an
afocal system; and

a restrictor having an aperture of a predetermined size on the ion-optical axis, the restrictor being located on a common
focal plane of a first-stage virtual convex lens formed by a portion of the five or more cylindrical electrodes and a second-stage
virtual convex lens formed by a portion of the five or more cylindrical electrodes under a condition that the voltages for
making the electrostatic lens become an afocal system are applied from the voltage supplier, wherein the restrictor sets the
angular distribution of ions.

US Pat. No. 9,230,785

ION TRAP MASS SPECTROMETER AND ION TRAP MASS SPECTROMETRY METHOD

SHIMADZU CORPORATION, Ky...

1. An ion trap mass spectrometer in which ions obtained by ionizing a sample are captured in an ion trap, and the ions are
dissociated and subjected to mass spectrometry to perform MSn analysis (n is an integer of 2 or greater), the ion trap mass spectrometer comprising:
a MS1 measurement processing section configured to measure a MS1 spectrum by performing mass spectrometry of the ionized sample;

a precursor ion detection processing section configured to detect, as MS2 precursor ions, ions corresponding to a plurality of peaks with the intensity or S/N ratio falling within a predetermined
range, based on the MS1 spectrum; and

a MS2 measurement processing section configured to measure a MS2 spectrum by dissociation of a plurality of ions, which are detected as MS2 precursor ions, at a time in the ion trap and subjecting the ions to mass spectrometry.

US Pat. No. 9,200,715

PASSAGE-SWITCHING VALVE

SHIMADZU CORPORATION, Ky...

1. A passage-switching valve having a stator and a rotor, the rotor being rotatable while sliding relative to the stator,
the stator having a plurality of passages whose ends are open on a sliding surface on which the rotor is made to rotate and
slide, and the rotor having a passage groove for connecting two or more of the plurality of passages, wherein:
the rotor, at an edge of the passage groove, is in contact with the sliding surface of the stator at a contact angle greater
than 120°.

US Pat. No. 9,273,785

FLOW CHANNEL SWITCHING VALVE

SHIMADZU CORPORATION, Ky...

1. A flow channel switching valve comprising:
a housing that has an internal space, the housing including a housing top having a plurality of connection ports connecting
flow channel piping in an outer surface thereof, and having, on a side of the internal space, a flow channel connection portion
where connection holes respectively leading to the connection ports are arranged on one plane, and a housing body that has
a depressed portion with a top open inside thereof and detachably holds the housing top on an open portion of the depressed
portion;

a stator that is arranged inside the internal space of the housing, has through-holes corresponding to the connection holes
of the flow channel connection portion, respectively, and is attached to a side of the housing top while keeping liquid tightness
to the flow channel connection portion in a state where the through-holes are positioned at the connection holes;

a rotor that is arranged inside the internal space of the housing, has a plane in contact with a surface of the stator on
an opposing side of the flow channel connection portion, and is provided with a groove in the plane, the groove forming a
flow channel selectively connecting between any one pair of the through-holes of the stator;

a rotor drive portion that is provided on a side of the housing body, includes a rotor drive shaft extending from the side
of the housing body toward the side of the housing top to hold the rotor at a forefront portion of the rotor drive shaft,
on the side of the housing top, and rotates the rotor by rotating the rotor drive shaft with an axial center thereof as a
rotation center;

an elastic member that is contained in the housing body so as to be extendable in an axial direction of the rotor drive shaft,
is in a compressed state when the rotor drive shaft is at a normal position, which is a position when the housing top is attached
to the housing body, and biases the rotor drive shaft at the normal position to the side of the housing top; and

a drive shaft stopper that is made up of a first engagement portion provided in the rotor drive shaft, and a second engagement
portion provided in the housing body, and limits movement of the rotor drive shaft to the side of the housing top by engaging
the first engagement portion and the second engagement portion to each other when the rotor drive shaft moves to the side
of the housing top from the normal position.

US Pat. No. 9,232,925

X-RAY DIAGNOSTIC APPARATUS AND STORAGE MEDIUM STORING X-RAY DIAGNOSTIC PROGRAM

SHIMADZU CORPORATION, Ky...

1. An X-ray diagnostic apparatus, comprising:
an X-ray emitter configured to emit X-rays to a subject;
an X-ray detector configured to detect X-rays transmitting through the subject; and
a grid disposed on an X-ray incidence side of the X-ray detector to remove scattered X-rays, and configured to obtain an image
in accordance with output from the X-ray detector,

the X-ray diagnostic apparatus further comprising:
a peak frequency detector configured to detect a peak frequency of a first harmonic in a moiré pattern of the grid appearing
in the image;

a first and second harmonic remover configured to remove the first harmonic and a second harmonic in the moiré pattern from
the image in accordance with the peak frequency of the first harmonic to obtain a first and second harmonic removed image;

a third harmonic extracting-filter generating unit configured to calculate a peak frequency of a third harmonic in the moiré
pattern in accordance with the peak frequency of the first harmonic to generate a third harmonic extracting filter to extract
the third harmonic;

a third harmonic extracting unit configured to extract the third harmonic from the first and second harmonic removed image
based on the third harmonic extracting filter;

a third harmonic subtracting unit configured to subtract the extracted third harmonic from the first and second harmonic removed
image to obtain a third harmonic removed image;

a flatness calculating unit configured to calculate flatness in the first and second harmonic removed image to obtain flatness
information; and

an output selecting unit configured to output the third harmonic removed image within a flat region of the flatness information,
and output the first and second harmonic removed image within a region out of the flat region of the flatness information.

US Pat. No. 9,214,327

VACUUM ANALYZER UTILIZING RESISTANCE TUBES TO CONTROL THE FLOW RATE THROUGH A VACUUM REACTION CHAMBER

SHIMADZU CORPORATION, Ky...

1. A vacuum analyzer comprising: a) a vacuum reaction chamber; wherein the vacuum reaction chamber is a collision chamber
for collision-induced dissociation configured to be used in a mass analysis system; b) a gas source for supplying a gas into
said vacuum reaction chamber; c) a flow rate restricting resistance tube, the outlet end of which is connected to said vacuum
reaction chamber; d) a pressure detection means disposed upstream from said flow rate restricting resistance tube; e) a flow
rate adjustment means which is disposed between said pressure detection means and said gas source and adjusts the flow rate
of gas flowing out of said flow rate restricting resistance tube so that the detected value from said pressure detection means
reaches a prescribed value; f) a split flow path which divides the gas flowing from the upstream between said flow rate adjustment
means and said pressure detection means and is provided with a split resistance tube; g) an atmosphere release path which
divides the gas flowing from the upstream between said flow rate adjustment means and said pressure detection means and releases
the divided gas into the atmosphere; and h) a valve provided in said atmosphere release path;
wherein said split flow path is connected immediately downstream from said valve of said atmosphere release path; a gas purging
resistance tube is provided downstream from where said split flow path connects to said atmosphere release path; and a resistance
to gas flow at least atmospheric pressure due to a length and an inside diameter of said gas purging resistance tube is smaller
than a resistance to gas flow at least atmospheric pressure due to a length and an inside diameter of said flow rate restricting
resistance tube, and is smaller than a resistance to gas flow at least atmospheric pressure due to a length and an inside
diameter of said split resistance tube, such that a flow rate of gas through said split flow path is at least an order of
magnitude greater than a flow rate of gas into said vacuum reaction chamber.

US Pat. No. 9,194,849

COLUMN UNIT AND GAS CHROMATOGRAPHY DEVICE PROVIDED WITH THE SAME

SHIMADZU CORPORATION, Ky...

6. A gas chromatography device comprising:
a column unit comprising:
a tubular housing including a first opening and a second opening, and an inner space separated from outside air by an insulating
material,

an air cooling section arranged on a side of the first opening of the housing, the air cooling section including a cooling
device,

a fan arranged on a side of the first or second opening of the housing, the fan being controlled to operate, when cooling
an inside of the inner space, to cause air to flow through the air cooling section in a direction from the side of the first
opening to a side of the second opening, and not to operate when heating the inside of the inner space or maintaining the
inside of the inner space at a constant temperature, and

a column section including a separation column, and a heater for heating the separation column, the column section being arranged
in the inner space of the housing in such a way that a gap through which air flows from the first opening to the second opening
when the fan is operated is formed between the column section and an inner wall of the inner space;

a sample injection section connected to an end of the separation column of the column unit;
a detector connected to another end of the separation column;
wherein the separation column is configured to include an inner channel, as a separation channel, on a flat channel substrate,
the heater is a flat heater, and is arranged on at least one plane of the separation column,
the column section has a stacked structure where the separation column and the heater are sandwiched between a pair of metal
plates, and the heater is pressed against the separation column by the pair of metal plates, and

the gap through which air is to flow is formed between the metal plates and the inner wall of the inner space.

US Pat. No. 9,164,028

SPECTROMETRIC MEASUREMENT DEVICE AND PROGRAM

SHIMADZU CORPORATION, Ky...

1. A spectrometric measurement device for casting an irradiation light into or onto a sample and measuring light obtained
from the sample due to an interaction between the irradiation light and the sample, comprising:
a) a data memory for storing first measurement data obtained by using, as the aforementioned sample, a solvent containing
no objective component and second measurement data obtained by using, as the aforementioned sample, the solvent containing
an objective component, each of the first and second measurement data being obtained by varying, over a redetermined wavelength
range, a wavelength of the irradiation light or a wavelength of light to be measured or by dispersing the light obtained from
the sample and simultaneously detecting the dispersed light at a plurality of wavelengths within a predetermined range; and

b) a sensitivity index estimator for calculating a value indicative of a degree of interaction between the objective component
and the irradiation light at each wavelength based on the first measurement data and the second measurement data, for calculating
an estimate of an amount of noise due to the solvent at each wavelength from the first measurement data, and for calculating
an estimate of a sensitivity index at each wavelength from a ratio between the value indicative of the degree of interaction
between the objective component and the irradiation light and the estimate of the amount of noise,

wherein:
the aforementioned interaction is an absorption by the sample, and the spectrometric measurement device is an absorbance determination
device including an irradiation optical system for casting light into or onto a sample and a transmission-light detector for
detecting the light that has passed through the sample;

the data memory is used for storing first measurement data obtained by using, as the aforementioned sample, a solvent containing
no objective component and second measurement data obtained by using, as the aforementioned sample, the solvent containing
an objective component, each of the first and second measurement data being obtained by varying, over a predetermined wavelength
range, a wavelength of the light cast into or onto the sample or a wavelength of the light to be detected, or by dispersing
the transmission light from the sample and simultaneously detecting the dispersed transmission light at a plurality of wavelengths
within a predetermined range;

the sensitivity index estimator is designed to calculate an absorbance of the objective component at each wavelength based
on the first measurement data and the second measurement data, to calculate an estimate of the amount of noise due to the
solvent at each wavelength from the first measurement data, and to calculate an estimate of the sensitivity index at each
wavelength from a ratio between the absorbance value of the objective component and the estimate of the amount of noise, and

the sensitivity index estimator calculates an output current Is of the transmission-light detector at each wavelength from the first measurement data and calculates an estimate ?A of the
amount of noise due to the solvent by a following equation:

?A=?{square root over (1/Is)}  (3)

US Pat. No. 9,466,474

TRIPLE QUADRUPOLE MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A triple quadrupole mass spectrometer having: a front quadrupole mass filter for selecting, as a precursor ion, an ion
having a specific mass-to-charge ratio from among various ions; a collision cell for dissociating the precursor ion by making
this ion collide with a predetermined collision gas; a rear quadrupole mass filter for selecting an ion having a specific
mass-to-charge ratio from among various product ions produced by the dissociation; and a detector for detecting the selected
product ion, the triple quadrupole mass spectrometer comprising:
a) a prior information storage section in which information showing a relationship between an optimum collision-gas pressure
giving a highest or nearly highest level of detection sensitivity and at least one parameter is previously stored, the one
parameter selected from a group consisting of a mass-to-charge ratio of the precursor ion, a mass-to-charge ratio of the product
ion, a sum of the mass-to-charge ratio of the precursor ion and the mass-to-charge ratio of the product ion, as well as a
collision energy; and

b) an optimum gas pressure calculator for calculating, based on the information stored in the prior information storage section,
the optimum collision-gas pressure corresponding to a measurement condition when at least one of following parameters is set
as the measurement condition: the mass-to-charge ratio of the precursor ion originating from a compound to be analyzed, the
mass-to-charge ratio of the product ion, and the collision energy in a measurement.

US Pat. No. 9,418,767

X-RAY FOCUSING DEVICE

Shimadzu Corporation, Ky...

1. An X-ray focusing device comprising:
a multi-capillary lens comprising a plurality of bundled capillaries for guiding X-rays, wherein at least one end face of
said multi-capillary lens is a converging end for concentrating and irradiating X-rays to a micro-area located outside of
the end face; and

a single-capillary lens comprising one capillary for guiding X-ray, wherein at least one end face of said single-capillary
lens is a converging end for irradiating X-ray to the micro-area located outside of the end face where the micro-area is smaller
than the irradiation area of the X-ray converged by the multi-capillary lens, and the other end face is a long-focal length
converging end or a parallel end capable of accepting parallel X-ray beams where the long-focal length converging end or the
parallel end has a focal length that is longer than the focal length of the converging end of the single-capillary lens for
irradiating X-ray, and

wherein the parallel end or the long-focal length converging end of said single-capillary lens is positioned outside the converging
end of said multi-capillary lens, and said multi-capillary lens and said single-capillary lens are positioned so that the
optical axis of said multi-capillary lens at the converging end coincides with the optical axis of the single-capillary lens
at the parallel end or the long-focal length converging end.

US Pat. No. 9,279,790

ANALYSIS METHOD FOR DYE FOR ORGANIC SOLAR CELL AND PURIFICATION METHOD THEREFOR

SHIMADZU CORPORATION, Ky...

1. An analysis method for analyzing a sample, the method comprising the steps of:
(A) providing a sample solution dissolved in an organic solvent, the sample solution containing a dye for dye-sensitized solar
cells;

(B) separating the sample solution by water-free normal-phase liquid chromatography; and
(C) detecting separated components,
wherein the dye is a metal complex having one or more aromatic heterocyclic ligands, and
wherein the water-free normal-phase liquid chromatography is an analysis method involving:
(B1) using a separation column filled with a column packing material which is prepared by modifying a base material with a
polar modifying group, and

(B2) using as an eluent a polar organic solvent containing an acid.

US Pat. No. 9,412,571

IMAGING MASS SPECTROMETRIC DATA PROCESSING METHOD AND IMAGING MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. An imaging mass spectrometric data processing method for processing imaging mass spectrometric data collected by performing
a mass spectrometry on each of a plurality of measurement points on a sample, the imaging mass spectrometric data including
a plurality of sets of mass spectrum data, where each set is composed of a one-dimensional array of ion-intensity values,
related to spatial position information of the measurement point, and the method comprising:
a) a compression step, in which a compression process is performed on the imaging mass spectrometric data of each measurement
point according to a predetermined algorithm, and the obtained compressed data are stored in a first storage area of a storage
unit;

b) a normalization coefficient preparation step, in which a normalization coefficient for normalizing the intensity values
in the imaging mass spectrometric data of each measurement point according to a predetermined criterion is calculated for
each measurement point, and the calculated result is stored in a second storage area of the storage unit;

c) a normalized spectrum creation step, in which at least one of an accumulated mass spectrum, an average mass spectrum or
a maximum intensity mass spectrum composed of maximum intensity values extracted at each mass-to-charge ratio, of normalized
mass spectra obtained at a plurality of designated or specific measurement points, is calculated as a normalized mass spectrum,
using the compressed data of the intensity values corresponding to each measurement point stored in the first storage area
of the storage unit, the normalization coefficient of each measurement point stored in the second storage area of the storage
unit, and the spatial position information of the measurement points; and

d) a normalized graphic creation step, in which an imaging graphic showing a two-dimensional distribution of the normalized
intensity values for a designated or specific mass-to-charge ratio or mass-to-charge-ratio range is created, using the compressed
data of the intensity values corresponding to each measurement point stored in the first storage area of the storage unit,
the normalization coefficient of each measurement point stored in the second storage area of the storage unit, and the spatial
position information of the measurement points.

US Pat. No. 9,079,972

METHOD OF SCREENING A SUBSTANCE FOR IMPROVING INSULIN RESISTANCE

SHIMADZU CORPORATION, Ky...

1. A method of screening a substance for improving cellular insulin resistance, comprising the steps of:
bringing an adipocyte capable of expressing or secreting a polypeptide having the amino acid sequence of SEQ ID NO: 1 into
contact with a candidate substance to stimulate the adipocyte to express or secrete the polypeptide;

isolating the polypeptide by solubilizing the adipocyte and extracting the polypeptide;
fragmenting the resulting polypeptide having the amino acid sequence of SEQ ID NO: 1 using trypsin;
measuring a level of a polypeptide fragment consisting of 13 continuous amino acids 297-309 of SEQ ID NO: 1 in the adipocyte
when the candidate substance is brought into contact; and

comparing the measured level of the polypeptide fragment consisting of the 13 continuous amino acids 297-309 of SEQ ID NO:
1 in the adipocyte when the candidate substance is brought into contact, with an expression level or a secretion level of
the polypeptide in the adipocyte when the candidate substance is not brought into contact,

wherein a reduction of the measured level of the polypeptide fragment consisting of the 13 continuous amino acids 297-309
of SEQ ID NO:1 when the candidate substance is brought into contact, compared with the expression level or the secretion level
when the candidate substance is not brought into contact, is regarded as one index for selecting the candidate substance as
a substance that improves cellular insulin resistance, and

wherein the step of bringing the adipocyte capable of expressing or secreting the polypeptide having the amino acid sequence
of SEQ ID NO: 1 into contact with a candidate substance is conducted in vitro.

US Pat. No. 9,370,589

SWITCHING FLUORESCENT NANOPARTICLE PROBE AND FLUORESCENT PARTICLE IMAGING METHOD USING SAME

SHIMADZU CORPORATION, Ky...

1. A fluorescent nanoparticle probe comprising:
a molecular assembly composed of an amphiphilie block polymer having a hydrophilic block chain and a hydrophobic block chain;
and

a fluorescent dye encapsulated in the molecular assembly, wherein
the amphiphilic block polymer is selected from the group consisting of a polysarcosine-polylactic acid amphiphilic block polymer,
a polyethylene glycol-polylactic acid amphiphilic block polymer, and a polysarcosine-poly (leucine-aminoisobutyric acid) amphiphilic
block polymer, and

the fluorescent dye is a cyanine compound represented by the following structural formula (I);

wherein R1 and R2 may be the same or different from each other and each is a hydrocarbon group Which may be substituted; R3 is a bivalent hydrocarbon group which may be substituted;

X is a halogen, an aryloxy group, or a thioaryloxy group; A? is an anion and m is 0 or 1; and a ring B and a ring D may be the same or different from each other and each is a nitrogen
containing bicyclic or tricyclic aromatic heterocycle, and

two or more molecules of the fluorescent dye are encapsulated in a self-quenching state by association in the single molecular
assembly,

wherein the fluorescent nanoparticle recovers fluorescence by contact with a blood component to deform the structure of the
molecular assembly composed of an amphiphilic block polymer and to dissociate the association of the two or more molecules
of the fluorescent dye; and

wherein fluorescence intensity in plasma is 10 times or more higher than that in phosphate buffered saline.

US Pat. No. 9,285,344

DISCHARGE IONIZATION CURRENT DETECTOR AND GAS CHROMATOGRAPH

SHIMADZU CORPORATION, Ky...

1. A discharge ionization current detector for detecting an ion current by introducing a sample gas into a tubular body through
a tubule, the tubular body having at a first end a cylindrical dielectric around the outer periphery of which an electrode
for discharge is formed, and the tubule for introducing a sample gas being inserted into the tubular body at a second end,
by ionizing said sample gas using plasma generated by applying a low frequency, alternating current voltage to said electrode
for discharge while allowing a gas for generating plasma to flow through said first end, and at the same time by collecting
the resulting ions around a collector electrode provided closer to said second end than said electrode for discharge, wherein
the discharge ionization current detector comprises:
an outlet for discharging a gas, created in said tubular body at a point closer to said second end than said collector electrode,
and

a partition, provided between the outlet for discharging a gas and said collector electrode in the direction in which the
tubular body is crossed, for separating the tubular body into a first chamber on the side of the first end where the sample
gas is ionized and a second chamber on the side of the second end, the first chamber having the electrode for discharge and
the collector electrode, the second chamber having the outlet for discharging the gas, the partition having a through hole
for allowing the first and second chambers to communicate with each other, wherein

the tubule is inserted into the through hole, and an opening at one end of the tubule is located closer to said first end
than the partition.

US Pat. No. 9,194,850

MEASUREMENT DEVICE FOR TOTAL ORGANIC CARBON

SHIMADZU CORPORATION, Ky...

1. A total organic carbon measuring device comprising:
a syringe pump for collecting sample water;
an oxidation reaction unit including a combustion tube for oxidatively decomposing and converting, into carbon dioxide carbon
components in the sample water collected by the syringe pump, and a heating furnace for heating the combustion tube;

a measurement unit including a sample cell, connected to an outlet portion of the combustion tube, for causing sample gas
containing carbon dioxide generated in the combustion tube to flow through, and a detector for measuring carbon dioxide concentration
in the sample gas flowing through the sample cell;

a carrier gas supply unit including a carrier gas introduction path for introducing, a carrier vas, a first supply path having
one end connected to a downstream end of the carrier gas introduction path and the other end connected in a manner capable
of communicating with the syringe pump, a second supply path, different from the first supply path, having one end connected
to the downstream end of the carrier gas introduction path and the other end connected to the combustion tube, a first flow
rate adjustment mechanism for adjusting a flow rate of the carrier gas flowing through the first supply path, and a second
flow rate adjustment mechanism for adjusting, independently from the first flow rate adjustment mechanism, a flow rate of
the carrier gas flowing through the second supply path;

a bypass path leading to the sample cell through neither the combustion tube nor the syringe pump for flowing the carrier
gas;

a path switching mechanism configured to switch between a sparging state and a normal state, the sparging state communicating
the other end of the first supply path with a drain through the syringe pump, and the normal state communicating the other
end of the first supply path to the sample cell through the bypass path; and

a system controller configured to control the first flow rate adjustment mechanism and the second flow rate adjustment mechanism
in such a way that the carrier gas flows through the first supply path and the second supply path at a predetermined flow
rate, the system controller including cell flow rate control means configured to control the first flow rate adjustment mechanism
and the second flow rate adjustment mechanism so that a flow rate of the carrier gas introduced into the sample cell through
the second supply path in the sparging state and a flow rate of the carrier gas introduced into the sample cell through both
the first and second supply paths in the normal state become the same.

US Pat. No. 9,194,391

SOLVENT DELIVERY PUMP PLUNGER BACKUP SEAL

SHIMADZU CORPORATION, Ky...

1. A solvent delivery pump comprising:
a pump head having a solution inlet for sucking a solution, a pump chamber for storing the solution sucked from the solution
inlet, and a solution outlet for discharging the solution in the pump chamber;

a plunger having a tip end inserted into the pump head to slide in the pump head;
a plunger seal mounted to a portion of the pump head through which the plunger is inserted, the plunger seal being disposed
at a position which is subjected to a high pressure of the pump chamber and having a ring shape provided with a hole through
which the plunger passes to seal a clearance between the pump head and the plunger; and

a disk-shaped backup ring mounted to a back face side of the plunger seal, provided with a hole through which the plunger
passes, wherein

the backup ring is a combined backup ring comprising first and second portions, the first portion having a face in contact
with the back face of the plunger seal and being substantially made of deformable resin, and the second portion having an
inner peripheral face of the hole through which the plunger passes and being substantially made of non-deformable resin;

the deformable resin has a higher elastic modulus than that of the plunger seal and has such an elastic modulus as to be able
to absorb deformation of the plunger seal, and the non-deformable resin has a higher elastic modulus than that of the deformable
resin;

wherein the first and second portions have triangular cross-sectional shapes in a plane common to an axis of the plunger.

US Pat. No. 9,472,386

CHROMATOGRAPH MASS SPECTROMETRY DATA PROCESSING APPARATUS

SHIMADZU CORPORATION, Ky...

1. A chromatograph mass spectrometry data processing apparatus for processing data collected by a chromatograph mass spectrometry
apparatus, the data processing apparatus performing alignment processing for correcting a shift in retention time in a plurality
of chromatograms obtained from data obtained for a plurality of specimens, and comprising:
a) a mass spectrum scaling processing unit for scaling signal intensities in a mass spectrum created, for each measurement
time point within an entire measurement time range or within part of the measurement time range, based on data obtained at
the measurement time point;

b) a total signal intensity value calculation unit for calculating, for each of the mass spectrum, a total signal intensity
value obtained by adding signal intensity values after being scaled by the mass spectrum scaling processing unit;

c) a chromatogram creating unit for creating, for each of a plurality of specimens, a total ion chromatogram from a plurality
of total signal intensity values calculated by the total signal intensity value calculation unit; and

d) an alignment execution unit for executing alignment processing using a plurality of chromatograms created by the chromatogram
creating unit.

US Pat. No. 9,279,802

CELL SORTER AND CELL SORTING METHOD

SHIMADZU CORPORATION, Ky...

1. A cell sorter comprising:
a well that has a microspace filled with a liquid and having a length of 1 mm or less and has a bottom surface made of a light-permeable
material allowing optical observation of an interior of the microspace;

a matrix provided on the bottom surface in the well;
a bone fragment placed on the matrix in the well; and
osteoclasts placed between the matrix and the bone fragment.

US Pat. No. 9,101,761

MOVING OBJECT TRACKING SYSTEM FOR RADIOTHERAPY

NATIONAL UNIVERSITY CORPO...

1. A moving object tracking system for radiotherapy for tracking a moving object concerning a treatment part by X-ray fluoroscopy
in order to irradiate the treatment part with radiation, comprising:
an X-ray tube having a fixed direction of X-ray irradiation for the X-ray fluoroscopy;
an X-ray detecting device with a detecting plane having a fixed direction for detecting X-rays emitted from the X-ray tube
to carry out the X-ray fluoroscopy; and

two U-shaped tracks for the X-ray tube and the X-ray detecting device, each having two straight tracks arranged opposite each
other, and a curved track connected thereto;

wherein the U-shaped track for the X-ray tube and the U-shaped track for the X-ray detecting device are arranged opposite
each other when seen in plane view.

US Pat. No. 9,046,533

METHOD AND SYSTEM FOR SYNCHRONOUSLY DRIVING LIGHT-DISPERSING ELEMENTS, AND DETECTOR FOR CHROMATOGRAPH

SHIMADZU CORPORATION, Ky...

1. A method for synchronously driving light-dispersing elements for driving a first light-dispersing element and a second
light-receiving element in a light-dispersing including:
a first light-dispersing unit having the first light-dispersing element and a first pulse motor for driving the first light-dispersing
element;

a second light-dispersing unit having the second light-dispersing element and a second pulse motor for driving the second
light-dispersing element; and

a pulse transmitter for transmitting a first pulse number of pulses to the first pulse motor and a second pulse number of
pulses to the second pulse motor,

wherein the first pulse number of pulses is necessary for sequentially changing, at predetermined intervals, a wavelength
of monochromatic light produced by the first light-dispersing device, and

wherein the second pulse number of pulses is necessary for sequentially changing, at predetermined intervals, a wavelength
of monochromatic light produced by the second light-dispersing device, and

the method comprising the steps of:
determining a transmission rate of the first pulse number of pulses based on a pulse rate within a start region, a stop region,
or a slew range of the first pulse motor;

calculating a first pulse transmission time from the first pulse number of pulses and the transmission rate of the first pulse
number of pulses; and

transmitting the second pulse number of pulses to the second pulse motor within the first pulse transmission time.

US Pat. No. 9,048,075

TIME-OF-FLIGHT TYPE MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A time-of-flight type mass spectrometer for accelerating ions generated from a sample, introducing the ions into a flight
space, and separating and detecting the ions in accordance with a mass/charge ratio within the flight space, the time-of-flight
type mass spectrometer comprising:
a) an extraction electrode disposed at a prescribed distance from a sample holding part for holding a sample;
b) one or a plurality of auxiliary electrodes disposed between the sample holding part and the extraction electrode;
c) a voltage generator for applying prescribed voltages to the sample holding part, the auxiliary electrode, and the extraction
electrode to form an electric field for extracting and accelerating ions from the sample surface in a space between the sample
holding part and the extraction electrode; and

d) a controller for controlling the voltage generator so as to keep the potential of the sample holding part higher than the
potential of the extraction electrode by a first potential difference so that an extraction electric field in which ions move
in accordance with the mass/charge ratio from the sample surface toward the extraction electrode is formed during a period
until a prescribed delay time has passed after the point in time when ion generation is begun, to sequentially increase the
potentials of the extraction electrode, the auxiliary electrode, and the sample holding part so that an acceleration electric
field in which ions present in the space between the sample holding part and the extraction electrode are simultaneously accelerated
in the direction of the extraction electrode and the slope of the potential gradient of the acceleration electric field along
the ion optical axis is a relatively larger polygonal line pattern on the sample holding part side than on the extraction
electrode side and to make the potential of the sample holding part with respect to the potential of the extraction electrode
higher than the first potential difference by a second potential difference at the point in time when the delay time has passed
and thereafter.

US Pat. No. 9,551,617

RAMAN SPECTROSCOPIC ANALYZER

SHIMADZU CORPORATION, Ky...

1. A Raman spectroscopic analyzer, comprising:
a) a sample-passing unit in a form of a tube, for passing a fluid sample in a longitudinal direction of the tube;
b) a beam-casting unit for converging a light beam generated by a light source on a predetermined position within the sample-passing
unit; and

c) a light-receiving unit placed at a distance in the longitudinal direction from the predetermined position, including a
light-receiving lens for receiving scattered light emitted from the fluid sample.

US Pat. No. 9,048,082

TIME-OF-FLIGHT MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A time-of-flight mass spectrometer in which ions are accelerated and introduced into a flight space, and in which the ions
are detected after being separated according to their mass-to-charge ratios while flying in the flight space, the time-of-flight
mass spectrometer having a grid-like electrode for creating an electric field for accelerating and/or decelerating the ions
while allowing the ions to pass through, wherein:
the grid-like electrode is a structure having a thickness equal to or greater than two times a size of a smaller dimension
of an opening of the grid-like electrode, the thickness being a dimension along the travelling direction of the ions passing
through the opening.

US Pat. No. 9,490,114

TIME-OF-FLIGHT MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A time-of-flight mass spectrometer comprising:
an ion ejector configured to impart a predetermined amount of energy to target ions;
an electric field-free ion drift region configured to let the ions drift;
an ion reflector, including a plurality of plate-like electrodes that provide an electric field, disposed along an ion path
and configured to receive ions from the electric field-free ion drift region and to reflect and return, with action of the
electric field, the ions to the electric field-free ion drift region;

a detector configured to detect the ions reflected by the ion reflector, wherein
a flight space of the ions in the ion reflector is sectioned into a first region where the ions passed through the electric
field-free ion drift region are decelerated and a second region where the ions passed through the first region are reflected,

wherein a plurality of electrodes disposed in the second region has a same thickness,
wherein a thickness of any electrode in the second region is smaller than a thickness of any electrode in the first region,
and

wherein a mass resolving power of the time-of-flight mass spectrometer is 10000 or more.

US Pat. No. 9,384,957

MASS ANALYSIS DEVICE AND MASS CALIBRATION METHOD

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer provided with an ion dissociator for dissociating ions originating from a compound in a sample and
a mass analyzer for performing mass analysis on ions generated by an ion dissociation operation of the ion dissociator and
configured to be able to perform MSn (where n is an integer equal to or larger than 2) analysis, the mass spectrometer comprising:
a) an analysis controller for causing the ion dissociator to perform a dissociation operation with a dissociation condition
adjusted such that a peak corresponding to a known mass-to-charge ratio and observed in an MS1 spectrum obtained without performing an ion dissociation operation remains in an MSn spectrum;

b) a spectrum creator for creating the MSn spectrum based on spectral data obtained when the dissociation operation is performed by the ion dissociator under control
of the analysis controller; and

c) a mass calibration processing unit for detecting the peak corresponding to the known mass-to-charge ratio in the MSn spectrum created by the spectrum creator and calibrating mass-to-charge ratios at respective peaks in the MSn spectrum using a difference between an actual measured value and a known value of the mass-to-charge ratio at the peak,

wherein
the peak corresponding to the known mass-to-charge ratio is a peak of a precursor ion for MSn analysis or a peak of an isotopic ion which has a same composition of elements as the precursor ion and contains an element
other than a stable isotope.

US Pat. No. 9,354,114

SPECTROPHOTOMETER INCLUDING PHOTODIODE ARRAY

SHIMADZU CORPORATION, Ky...

1. A spectrophotometer comprising:
a) a slit;
b) a diffraction grating which wavelength-disperses an incident light passing through the slit; and
c) a photodiode array including a plurality of light intensity measurement elements arranged in a direction of the wavelength
dispersion by the diffraction grating, wherein

a first plane which is perpendicular to a grating line and passes through an intersection point between an optical axis of
the incident light and a grating surface of the diffraction grating is not coincident with a second plane which is perpendicular
to surfaces of the light intensity measurement elements and passes through a central line of the photodiode array;

wherein the central line of the photodiode array is a line connecting centers of the plurality of light intensity measurement
elements.

US Pat. No. 9,298,906

ANALYZING APPARATUS VALIDATING SYSTEM AND PROGRAM FOR THE SYSTEM

SHIMADZU CORPORATION, Ky...

1. An analyzing apparatus validating system that executes validation of an analyzing apparatus system, the analyzing apparatus
validating system comprising a computer comprising:
a parameter acquiring unit acquiring a parameter for qualification implementation of the analyzing apparatus system from an
electronically supplied qualification plan document describing a qualification plan and an electronically supplied qualification
implementation procedure manual of the analyzing apparatus system describing a qualification implementation procedure, both
the electronically supplied qualification plan document and the electronically supplied qualification implementation procedure
manual being prepared by an apparatus manufacturer and a user;

a validation executing unit executing the validation of the analyzing apparatus system using the acquired parameter for qualification
implementation; and

a report creating unit creating, in a predetermined format, a qualification report of the analyzing apparatus system on a
basis of a validation result obtained by executing the validation.

US Pat. No. 9,826,613

X-RAY TUBE ASSEMBLY AND METHOD FOR ADJUSTING FILAMENT

Shimadzu Corporation, Ky...

1. An X-ray tube assembly for generating an X-ray, comprising:
a filament including a plurality of electric flow paths; and
an adjustor configured to adjust at least one of values of current flowing through the plurality of electric flow paths, by
varying a non-zero current value of the at least one of values of current flowing through the plurality of electric flow paths,
to adjust an electron emission area of the filament.

US Pat. No. 9,839,932

SURFACE CHEMICAL TREATMENT APPARATUS FOR DRAWING PREDETERMINED PATTERN BY CARRYING OUT A CHEMICAL TREATMENT

SHIMADZU CORPORATION, Ky...

5. A surface chemical treatment apparatus, comprising:
a container that contains a liquid phase medium in which a solid phase surface on which a patterning process is to be carried
out is immersed;

a stage on which said container is placed;
a moving mechanism for moving said stage;
a dual conduit made up of a first conduit having a first opening at the bottom end and a second conduit which is arranged
so as to surround said first conduit and which has a second opening that surrounds said first opening;

a pipe which communicates with the upper end of said first conduit and through which a patterning solution is supplied via
a pump for injection;

a conduit for supplying a sheath liquid which is connected to an opening for sheath formation provided in proximity to the
upper end of said first conduit and through which the sheath liquid is supplied via a pump for supplying the sheath liquid;
and

a pipe that communicates with the upper end of said second conduit and is connected to a pump for discharge that suctions
a liquid, wherein

said first opening and said second opening are arranged so as to face the solid phase surface within said liquid phase medium,
and

a pattern is drawn on the solid phase surface through a chemical treatment by moving said stage while allowing the patterning
solution to be dispensed through the first opening, and at the same time, allowing the patterning solution to be suctioned
up together with the liquid phase medium through the second opening.

US Pat. No. 9,147,269

RADIATION TOMOGRAPHIC IMAGE GENERATING METHOD, AND RADIATION TOMOGRAPHIC IMAGE GENERATING PROGRAM

SHIMADZU CORPORATION, Ky...

1. A radiation tomographic image generating method for generating tomographic images based on a plurality of radiological
images acquired by radiation beams emitted from different directions to an inspection object, respectively, the radiation
tomographic image generating method comprising:
an extraction separation step for extracting and separating, from the acquired radiological images, images of a substance
extraneous to a substance forming an area of interest in the inspection object;

an area interpolation step for generating interpolation images by interpolating an area of the extraneous substance, from
peripheral regions thereof, in the images of the extraneous substance extracted and separated in the extraction separation
step;

a first tomographic image generating step for generating tomographic images from the interpolation images generated with the
area of the extraneous substance interpolated in the area interpolation step;

an extraneous projection data generating step for generating extraneous projection data which is projection data of the extraneous
substance, from differences between the acquired radiological images and the interpolation images;

a second tomographic image generating step for generating tomographic images from the extraneous projection data generated
in the extraneous projection data generating step; and

a tomographic image synthesizing step for synthesizing the tomographic images generated in the first tomographic image generating
step and the tomographic images generated in the second tomographic image generating step.

US Pat. No. 9,588,125

METHOD AND SYSTEM FOR ANALYZING PROTEIN OR PEPTIDE

SHIMADZU CORPORATION, Ky...

1. A method for analyzing a protein or peptide for determining at least an amino-acid composition of a protein or a peptide,
an amino-acid sequence of the protein or the peptide or quantities of amino acids in the protein or the peptide, comprising:
a) a fragmentation step, in which a peptide originating from an analysis target which is either a peptide or a protein is
broken down into peptide fragments by breaking peptide bonds using a broad-spectrum endopeptidase;

b) a separation step, in which a mixture of the peptide fragments obtained in the fragmentation step is separated according
to kinds of peptide fragments and collected in a form of fractions, each fraction containing a same kind of peptide fragment,

c) a fragment composition deduction step, in which mass spectrum data are obtained by performing a mass spectrometry on each
of the peptide fragments separated in the separation step and in which an amino-acid composition of each peptide fragment
is deduced based on mass spectrum data; and

d) a sequence deduction step, in which the amino-acid sequence of the peptide or protein is deduced, based on the amino-acid
sequence of each of the peptide fragments deduced in the fragment composition deduction step, by combining different peptide
fragments, the different peptide fragments include at least a first peptide fragment, a second peptide fragment, and a third
peptide fragment; the first peptide fragment including a sequence pattern located in an end portion of the first peptide fragment
that matches a sequence pattern located in a beginning portion of the second peptide fragment, and the second peptide fragment
including a sequence pattern located in an end portion of the second peptide fragment that matches a sequence pattern located
in a beginning portion of the third peptide fragment;

wherein the amino-acid composition of the protein or the peptide before fragmentation, the amino-acid sequence of the protein
or the peptide or the quantities of amino acids in the protein or the peptide before fragmentation is deduced by performing
step (d) for each of the peptide fragments separately collected in the separation step.

US Pat. No. 9,877,368

OPTICAL ANALYZER

SHIMADZU CORPORATION, Ky...

1. An optical analyzer for analyzing a sample, the optical analyzer comprising:
a) a light source driven by a driving current for emitting light from a first light emitting point and a second light emitting
point;

b) an optical unit provided on an optical line from the light source to the sample for producing focused light from light
emitted from the first light emitting point, the focused light being focused on the sample, while producing unfocused light
from light emitted from the second light emitting point;

c) a photodetector arranged at a same side of the optical unit as the sample which the unfocused light reaches; and
d) a controlling unit for controlling the driving current based on an intensity signal generated by the photodetector such
that an amount of light emitted from the light source is at a fixed level.

US Pat. No. 9,721,776

SAMPLE PREPARATION METHOD AND SAMPLE PREPARATION DEVICE FOR MALDI INCLUDING DEPOSITING MATRIX SUBSTANCE ON SAMPLE SUBSTRATE IN TWO STEPS

SHIMADZU CORPORATION, Ky...

1. A sample preparation method for MALDI, the sample preparation method for preparing a sample for mass spectroscopy using
a matrix assisted laser desorption ionization method and configured to execute steps, comprising:
a) a matrix depositing step for vaporizing a matrix substance in vacuum and depositing the matrix substance to form a matrix
layer on a surface of a sample substrate on which a sample to be measured is placed;

b) a solvent introducing step for bringing a predetermined solvent in gaseous or liquid into contact with a surface of the
matrix film layer formed on the sample substrate so as to infiltrate the solvent into the matrix film layer; and

c) a matrix re-depositing step for vaporizing the matrix substance in vacuum and depositing the matrix substance again on
the surface of the matrix film layer in a state where the solvent is infiltrated, or in a state where the infiltrated solvent
is volatilized.

US Pat. No. 9,338,868

RADIOGRAPHIC EQUIPMENT

SHIMADZU CORPORATION, Ky...

1. Radiographic equipment for detecting, by an x-ray detector, x-rays that have been emitted from an x-ray tube and that have
passed through an examination subject, comprising:
storage storing, as a filament current setting value, a filament current that is to be supplied to a filament of the x-ray
tube under imaging conditions, from the imaging conditions of the tube current and tube voltage that are supplied to the x-ray
tube at the time of radiographic imaging;

a tube current value difference measuring device measuring over time, as a tube current value difference, a difference between
an anticipated value for the tube current when x-ray emission is performed at a given filament current and a measured value
for the tube current when x-ray emission is actually performed at that filament current; and

a filament current setting value correcting device correcting the filament current setting value that has been stored in the
storage so that the tube current value difference is reduced, when a calculation processing value from tube current value
differences obtained by a plurality of x-ray exposure during a specific period exceeds a setting value that has been set in
advance.

US Pat. No. 9,322,786

SOLAR CELL INSPECTION APPARATUS AND SOLAR CELL PROCESSING APPARATUS

SHIMADZU CORPORATION, Ky...

1. A solar cell inspection apparatus adapted to inspect a solar cell deposited with an antireflective film, the solar cell
inspection apparatus comprising:
visible light irradiation means adapted to irradiate visible light to the solar cell from an antireflective film side of the
solar cell;

reflection image measuring means adapted to measure a reflection image based on the visible light that is irradiated from
the visible light irradiation means and reflected by the antireflective film of the solar cell;

infrared light irradiation means adapted to irradiate infrared light from a side opposite to the antireflective film of the
solar cell;

transmission image measuring means adapted to measure a transmission image based on the infrared light that is irradiated
from the infrared light irradiation means and transmits through the solar cell;

comparison means adapted to compare the reflection image measured by the reflection image measuring means and the transmission
image measured by the transmission image measuring means with each other; and

determination means adapted to determine, of areas respectively appearing as bright spots in the reflection image, an area
appearing as a dark spot in the transmission image as an area including a foreign substance present on the antireflective
film, and also determine, of the areas respectively appearing as the bright spots in the reflection image, an area other than
the area determined as the area including the foreign substance as an area including a pinhole formed in the antireflective
film.

US Pat. No. 9,050,023

X-RAY APPARATUS

SHIMADZU CORPORATION, Ky...

1. An X-ray apparatus for conducting X-ray radiography, comprising:
an X-ray irradiating device for irradiating a subject with X-rays;
an X-ray detecting device for detecting X-rays transmitting through the subject;
an image combining device for combining two or more X-ray images;
a light illuminating device for illuminating the subject;
an edge determining device for determining an edge of an imaging area of an image combined by the image combining device based
on the illumination by the light illuminating device; and

a control device for performing control such that light from the light illuminating device is not emitted outside beyond a
possible imaging area, set in advance, when the edge of the imaging area determined by the edge determining device is beyond
the possible imaging area.

US Pat. No. 9,366,680

METHOD FOR EVALUATING MYOCARDIAL ISCHEMIC STATE USING BLOOD SAMPLE

SHIMADZU CORPORATION, Ky...

4. A method for assessing coronary restenosis in a test subject after percutaneous coronary intervention (PCI) based on a
ratio between specific B-type natriuretic hormone (BNP) molecules, the method comprising:
immunologically enriching a B-type natriuretic hormone (BNP) molecular group containing BNP 5-32 molecule (SEQ ID No. 4) and
a molecule having a mass number larger than that of BNP 5-32 molecule by 16 Da from a blood sample obtained from the test
subject at a time after PCI by contacting the blood sample with a solid phase-immobilized or -immobilizable antibody specific
for the BNP molecular group to form an immobilized immune complex, wherein the antibody is KYBNPII anti-BNP monoclonal antibody,

isolating the immobilized immune complex from other components of the blood sample,
eluting the BNP molecular group from the isolated immune complex,
detecting levels of the BNP 5-32 molecule (SEQ ID No. 4) and the molecule having a mass number larger than that of the BNP
5-32 molecule by 16 Da in the eluate, thereby distinguishing and quantifying the individual BNP molecules different in mass
number in the blood sample,

calculating a ratio between the detected level of the molecule having a mass number larger than that of the BNP 5-32 molecule
by 16D to the detected level of the BNP-5-32 molecule, and

assessing coronary restenosis after PCI in the test subject based on the calculated ratio, wherein a ratio higher than that
in control test subjects without restenosis is indicative of coronary restenosis after PCI in the test subject.

US Pat. No. 9,312,115

MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer comprising:
a mass analyzer for mass-separating ions to be analyzed provided inside a vacuum chamber configured to be evacuated by a vacuum
pump; and

a detector for detecting the mass-separated ions provided inside the vacuum chamber,
wherein:
the detector is fixed to the vacuum chamber via a cushioning member.

US Pat. No. 9,134,274

DISCHARGE IONIZATION CURRENT DETECTOR

SHIMADZU CORPORATION, Ky...

1. A discharge ionization current detector comprising:
a dielectric tube through which plasma generating gas flows;
a plasma generating unit formed from one section of the dielectric tube in a flow direction of the plasma generating gas,
the plasma generating unit including, in the section, a plurality of discharging electrodes attached on an outer circumferential
surface of the dielectric tube so as to encircle an outer circumference of the dielectric tube, wherein the plurality of discharging
electrodes are arranged, spaced from one another, along the flow direction of the plasma generating gas and wherein plasma
is generated by generation of dielectric barrier discharge among the discharging electrodes;

a casing including a connection portion to which a lower end portion, in the flow direction of the plasma generating gas,
of the dielectric tube is connected, a space having an inner diameter larger than an outer diameter of the end portion of
the dielectric tube, a sample gas inlet, provided at a position facing the connection portion, for introducing sample gas
into the space, and an exhaust port for exhausting gas inside the space;

a sample ionization unit provided inside the casing; and
an ion current detection unit for detecting a sample component ionized by the sample ionization unit,
wherein the lower end, in the flow direction of the plasma generating gas, of the dielectric tube protrudes into the space
inside the casing.

US Pat. No. 9,437,390

X-RAY TUBE DEVICE

SHIMADZU CORPORATION, Ky...

1. An X-ray tube device comprising:
a cathode generating an electron beam;
an anode generating an X-ray by collision of the electron beam from the cathode;
an envelope internally housing the cathode and the anode;
a magnetic field generator including a magnetic pole arranged to be opposed to the envelope, generating a magnetic field for
focusing and deflecting the electron beam from the cathode to the anode; and

an electric field relaxing electrode arranged between the magnetic pole and the envelope, having an outer surface having a
rounded shape.

US Pat. No. 9,396,920

IONIZATION CHAMBER

SHIMADZU CORPORATION, Ky...

1. An ionization chamber provided between a liquid chromatograph unit and a mass spectrometer, comprising:
an atomization means for spraying a liquid sample that has been fed from said liquid chromatograph unit in the Z direction
in said ionization chamber while ionizing the liquid sample; and

an ion introducing pipe of which an entrance portion is created within said ionization chamber in the horizontal direction
that is perpendicular to the Z direction and of which an exit portion is created so as to introduce ions into said mass spectrometer
unit, characterized in that

an opening in said entrance portion has such a form as to correspond to the spread in the XY plane of the liquid sample sprayed
in the Z direction.

US Pat. No. 9,384,953

TANDEM QUADRUPOLE MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A tandem quadrupole mass spectrometer comprising: a front-stage quadrupole mass filter for selecting, as precursor ions,
ions having a specific mass-to-charge-ratio from among a variety of ions; a collision cell for causing the precursor ions
to collide with a predetermined gas to dissociate the ions; a rear-stage quadrupole mass filter for selecting ions having
a specific mass-to-charge-ratio from among a variety of product ions produced through the dissociation; and a detector for
detecting the selected product ions, the tandem quadrupole mass spectrometer further comprising:
a) a gas supplier for supplying the predetermined gas to an inside of the collision cell;
b) a setting information memory for storing information on a gas pressure of the predetermined gas inside the collision cell
or control information for supplying the predetermined gas, in association with a scan speed of a mass scan in a measurement
mode in which the front-stage quadrupole mass filter performs the mass scan; and

c) an analysis controller for controlling the gas supplier such that the gas pressure of the predetermined gas inside the
collision cell accords with a scan speed of a mass scan to be performed, based on the information stored in the setting information
memory, during execution of a measurement mode in which at least the front-stage quadrupole mass filter performs the mass
scan.

US Pat. No. 9,257,257

ELECTRON BEAM CONTROL METHOD, ELECTRON BEAM GENERATING APPARATUS, APPARATUS USING THE SAME, AND EMITTER

SHIMADZU CORPORATION, Ky...

1. An electron beam control method comprising an electron beam generating step of emitting electrons from the conical end
of an emitter sharpened in the shape of a cone on the emission side of an electron beam by using a Schottky effect under an
electric field applied to the conical end to thereby generate an electron beam, the method further comprising:
a curvature radius adjusting step of adjusting a radius of curvature of the conical end;
an electron gun focal length control step of controlling an electron gun focal length of an electron beam by a radius of curvature
adjusted in the curvature radius adjusting step; and

an angular current density control step of controlling an angular current density of an electron beam with a focal length
controlled by the electron gun focal length control step,

wherein the electron beam generating step is conducted each time emission of an electron beam in a state where an angular
current density is controlled after the angular current density control step.

US Pat. No. 9,508,535

ION-MOBILITY SPECTROMETER INCLUDING A DECELERATING ION GATE

SHIMADZU CORPORATION, Ky...

1. An ion mobility spectrometer comprising:
an ion source for generating ions;
an ion detector for recording ions, and
a number of substantially flat diaphragm electrodes arranged substantially perpendicular to a straight system axis that passes
through apertures in said diaphragms, with the diaphragms being arranged in a series of cells with each cell comprising an
entrance diaphragm and an exit diaphragm and a short region in between, wherein the exit diaphragm of one cell is identical
to the entrance diaphragm of the next cell, and wherein said cells of said ion mobility spectrometer are grouped into three
parts:

an ion-beam forming region comprising at least one of said cells with its diaphragms having circular, elliptical or polygonal
apertures of substantially equal areas ?0;

an ion analyzing region comprising at least one of said cells with its diaphragms having circular, elliptical or polygonal
apertures whose areas are substantially equal but larger than ?0; and

a decelerating ion gate placed downstream of said ion-beam forming region and upstream of said ion analyzing region wherein
said decelerating ion gate comprises at least two cells, an initial cell A of length lA and a final cell B of length lB, wherein an entrance diaphragm of said cell A is equal to or greater than a last diaphragm of the ion-beam forming region
having an aperture of area ?0, while an exit diaphragm of said cell B is identical to a first diaphragm of the ion analyzing region having an aperture
whose area is substantially larger than ?0, while diaphragms between the entrance diaphragm of said cell A and the exit diaphragm of said cell B have apertures whose
areas are in between the area of the aperture of the entrance diaphragm of said cell A and the area of the aperture of the
exit diaphragm of said cell B.

US Pat. No. 9,480,442

ACCESSORY MOUNTING DEVICE AND ACCESSORY HAVING THE SAME FOR A RADIOGRAPHIC APPARATUS

SHIMADZU CORPORATION, Ky...

1. An accessory mounting device, wherein the accessory mounting device is operative to mount an accessory used in radiography
to a spacing support of a radiographic apparatus, comprising:
a fixing member having a pin engageable with a fixing concave element formed in said spacing support;
said fixing member operative to move between an engagement position where said pin engages with said concave element and a
distant position where said pin is distant from said fixing concave element;

a movement restriction member;
said movement restriction member operative to move between a restriction position wherein said movement restriction member
operably restricts said fixing member arranged at said engagement position from moving from said engagement position to said
distant position and a safe position operably allowing said fixing member to move between said engagement position and said
distant position;

a lock mechanism selectively operative to prevent an unintended movement of said movement restriction member from said restriction
position to said safe position; and

a bias member that provides a bias force to said movement restriction member in a direction toward said restriction position.

US Pat. No. 9,459,150

FOURIER TRANSFORM INFRARED SPECTROPHOTOMETER

SHIMADZU CORPORATION, Ky...

1. A Fourier transform infrared spectrophotometer comprising:
a) a sample chamber,
b) an accessory detachably installed in the sample chamber to which accessory information representing a type of the accessory
is provided,

c) an interference optical system,
d) a common base on which the sample chamber and the interference optical system are mounted;
e) an accessory information reader for reading the accessory information when the accessory is mounted in the sample chamber;
and

f) a setting condition changer having a parameter table for changing a setting condition for the interference optical system
depending on the accessory based on the accessory information read by the accessory information reader.

US Pat. No. 9,418,415

TRABECULAR BONE ANALYZER

SHIMADZU CORPORATION, Na...

1. A trabecular bone analyzer, comprising:
a radiation source configured to emit radiation at a discrete number of intermittent periods;
a radiation source moving unit configured to move the radiation source in a linear direction along an axis of a subject;
a detector configured to detect radiation that has passed through the subject at the discrete number of intermittent periods;
a detector moving unit configured to move the detector synchronously with movement of the radiation source in the linear direction
and maintain a consistent distance between the radiation source and the detector;

an image generator configured to generate images based on radiation detected at each of the discrete number of intermittent
periods by the detector as the radiation source and the detector move in the linear direction; and

an image reconstructing computing device configured to divide each of the images into a plurality of image sections according
to an angle of incidence of radiation and connect image sections having a same angle of incidence of radiation to form multiple
long images along the axis of the subject,

wherein each of the multiple long images has an angle of incidence of radiation that is different from others of the multiple
long images.

US Pat. No. 9,366,656

ANALYSIS DEVICE PROVIDED WITH DISCHARGE IONIZATION CURRENT DETECTOR

SHIMADZU CORPORATION, Ky...

1. An analysis device comprising:
a discharge ionization current detector including a plasma generation section that generates dielectric-barrier discharge
by applying high AC voltage between a plurality of electrodes attached on an outer circumference of a dielectric tube, a sample
ionization section that is arranged on a side of one end of the dielectric tube and that ionizes a sample by excitation light
emitted at a time of discharge in the plasma generation section, and a sample ion detection section that detects a sample
ionized by the sample ionization section as a current;

a plasma gas supply section for supplying plasma gas from a side of the other end of the dielectric tube while variably adjusting
a flow rate of the plasma gas;

a sample gas supply section for supplying sample gas to the sample ionization section from a side opposite the dielectric
tube;

a flow rate setting condition holding section for holding, as a flow rate setting condition, a relationship between a sample
gas supply flow rate from the sample gas supply section and a supply flow rate of plasma gas to be set with respect to the
sample gas supply flow rate; and

a gas flow rate controller configured to set a plasma gas supply flow rate from the plasma gas supply section to a flow rate
according to the sample gas supply flow rate, based on the flow rate setting condition held in the flow rate setting condition
holding section,

wherein the flow rate setting condition held in the flow rate setting condition holding section includes, as a minimum setting
condition, a relationship between the sample gas supply flow rate and a minimum plasma gas supply flow rate that does not
allow sample gas to enter the plasma generation section, as contrasted with the sample gas supply flow rate.

US Pat. No. 9,341,566

RESIN TYPE IDENTIFICATION METHOD AND RESIN TYPE IDENTIFICATION APPARATUS

Mitsubishi Electric Corpo...

1. A resin type identification method for identifying a resin type of resin pieces conveyed in succession to a measurement
range by having a controller execute signal processing on the basis of time-series signal powers corresponding to infrared
reflection intensities obtained by emitting infrared light onto said measurement range at predetermined time intervals, said
controller implementing:
a selection step of selecting at least one identifying signal power for identifying the resin type of said resin pieces from
said time-series signal powers corresponding to measurement position of said each resin piece conveyed in succession, on the
basis of respective magnitudes of said time-series signal powers, the selection step selecting the at least one signal power
within a predetermined threshold range defined in advance as said identifying signal power from said time-series signal powers
corresponding to the measurement position of said each resin piece conveyed in succession; and

an identification step of identifying the resin type of said resin pieces on the basis of an infrared reflection spectrum
corresponding to said selected identifying signal power in the predetermined threshold range defined in advance.

US Pat. No. 9,220,465

RADIOGRAPHIC APPARATUS

SHIMADZU CORPORATION, Ky...

1. A radiographic apparatus comprising:
a radiation source for emitting radiation;
a radiation detecting device having a detecting surface for detecting the radiation;
a strut extending in a vertical direction for supporting the radiation detecting device;
(A1) a strut moving device for moving the strut in a horizontal direction that is orthogonal to a direction from the radiation
source toward the radiation detecting device;

(B1) a strut-movement control device for controlling the strut moving device;
a detector vertically-moving device for moving the radiation detecting device vertically relative to the strut;
a detector vertical-movement control device for controlling the detector vertically-moving device;
an image generating device for successively generating images of a subject based on detection data outputted from the radiation
detecting device;

a connecting device for connecting two or more images successively taken to generate a single image; and
an input unit for inputting an operator's instruction of a moving path for the radiation detecting device, the moving path
extending in a direction different from the vertical and horizontal directions,

the detecting surface being placed along a plane formed by the vertical and horizontal directions,
the strut-movement control device and the detector vertical-movement control device being configured to control the strut
moving device and the detector vertically-moving device to move the radiation detecting device along the moving path for successively
taking the images of the subject.

US Pat. No. 9,144,832

NEEDLE WASHING MECHANISM

Shimadzu Corporation, Ky...

1. A needle washing mechanism having: a plurality of needles which stand on a base side by side and each of which has a path
inside thereof through which a liquid passes; a plurality of washing ports each of which includes a washing hole having an
opening into which any one of the needles is inserted; and a needle cleaning liquid supply means for supplying a needle cleaning
liquid to each of the washing holes, the needle washing mechanism comprising:
a) a cap section, which is provided on an outer circumferential surface of each of the plurality of needles, for closing the
opening of each of the washing holes when the needle is inserted into the washing hole;

b) a biasing means for biasing each of the plurality of washing ports toward the opening; and
c) a disposal passage, which is provided in the washing port, for discharging the needle cleaning liquid from each of the
plurality of the washing holes.

US Pat. No. 9,134,441

TOMOGRAPHIC EQUIPMENT, IMAGING SYSTEM PROVIDED THEREWITH, AND IMAGING DATA ACQUISITION METHOD

SHIMADZU CORPORATION, Ky...

1. Tomographic equipment for performing coincidence of radiation generated from a subject with radiopharmaceutical administered
thereto to obtain a sectional image, comprising:
a counting device that counts radiation generated from the subject with radiopharmaceutical administered thereto;
a first physical quantity calculation device that calculates physical quantity with respect to a size of the subject;
a second physical quantity calculation device that calculates a noise equivalent count or an image noise in accordance with
radiation counted by the counting device; and

a third physical quantity calculation device that calculates a noise equivalent count or an image noise per size of the subject
by dividing the noise equivalent count calculated by the second physical quantity calculation device or the image noise calculated
by the second physical quantity calculation device by the physical quantity calculated by the first physical quantity calculation
device.

US Pat. No. 9,623,122

MOLECULAR ASSEMBLY USING BRANCHED AMPHIPHILIC BLOCK POLYMER, AND DRUG TRANSPORTATION SYSTEM

SHIMADZU CORPORATION, Ky...

1. A molecular assembly comprising:
a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising a polysarcosine and a hydrophobic
block comprising a polylactic acid chain; and

a functional substance F comprising a functional site and a polylactic acid chain, wherein
the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units,
and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or

the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units,
and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units, wherein the functional
site of the functional substance F is a site selected from the group consisting of a signal agent and a drug.

US Pat. No. 9,435,774

GAS CHROMATOGRAPH APPARATUS

SHIMADZU CORPORATION, Ky...

1. A gas chromatograph apparatus having a column which separates respective components contained in a gas sample introduced
via a carrier gas over time, wherein an analysis mode in which an analysis of said gas sample is executed and a standby mode
in which an analysis is not executed can be switched and executed, said gas chromatograph apparatus comprising:
a) a carrier gas flow path for introducing said carrier gas into said column;
b) a column protection gas flow path for introducing a column protection gas separate from said carrier gas into said column;
c) a flow path switching part provided between said carrier gas flow path and said column protection gas flow path and said
column so that only one of said carrier gas or said column protection gas is introduced into the column;

d) a flow path control part for introducing said carrier gas into said column at the time of said analysis mode and introducing
said column protection gas into said column at the time of said standby mode;

e) a flow controller having at least one control mode from among a constant linear velocity mode, a constant flow volume mode,
and a constant pressure mode as a mode for controlling a flow state of a gas introduced into said column;

f) a determination part for estimating at least one value of a linear velocity, a flow volume of the column protection gas,
and a pressure of the column protection gas when the gas introduced into said column is changed from said carrier gas to said
column protection gas without changing the control mode of said flow controller and parameters related to said mode at the
time of a transition from said analysis mode to said standby mode and determining whether the estimated value is within a
preset range; and

g) a change indication part for prompting a user to change the control mode of said flow controller and/or the parameters
related to said mode by means of a predetermined method if said determination part determines that said estimated value is
not within said range.

US Pat. No. 9,423,329

TESTING APPARATUS

Hitachi, Ltd, Tokyo (JP)...

1. A testing apparatus, comprising:
a plurality of 1-axis testing structures, each 1-axis testing structure comprising:
an actuator, which is configured to move linearly, thereby to apply a load onto a test body;
an actuator fixing base, which is configured to fix said actuator at a predetermined position;
a reaction base comprising a first chucking tool, which first chucking tool is configured to chuck the test body in cooperation
with a second chucking tool, which second chucking tool is provided at an end portion of said actuator; and

a base, on which said actuator fixing base and said reaction base are mounted,
wherein an axis of each of the plurality of 1-axis testing structures essentially passes through an axial center of each actuator,
respectively, wherein axes of the plurality of 1-axis testing structures cross at one point, and wherein said plurality of
1-axis testing structures are arranged so that the axes of the plurality of 1-axis testing structures are included in a same
plane, and

wherein said base of said one of said plurality of 1-axis testing structures is movable with respect to bases of other ones
of the plurality of 1-axis testing structures.

US Pat. No. 9,147,560

MASS SPECTROMETRY METHOD OF PHOSPHORYLATED PEPTIDES AND SUGAR CHAINS

SHIMADZU CORPORATION, Ky...

1. A method for mass spectrometry of phosphorylated peptides or sugar chains, the method comprising using, as a liquid matrix,
an ionic liquid comprising a 3-aminoquinoline ion and a p-coumaric acid ion.
US Pat. No. 9,517,472

DEVICE AND METHOD FOR PROCESSING TARGET COMPONENT IN TUBE

SHIMADZU CORPORATION, Ky...

1. A device for manipulating a target component in a manipulation tube, comprising:
a manipulation tube comprising a tube having an optionally-closeable open end for supplying a sample containing a target component
at one end and a closed end at the other end, and a manipulation medium accommodated in the tube and having a gel layer and
an aqueous liquid layer alternately layered in a longitudinal direction of the tube, wherein the gel layer is a gel plug provided
on either side of the aqueous liquid layer so that the aqueous liquid layer is sandwiched between the gel plugs in the longitudinal
direction of the tube, and is fixed in a predetermined position in the tube;

magnetic particles that should capture and transport the target component; and
a magnetic field applying member capable of applying a magnetic field to the manipulation tube to move the magnetic particles
in the longitudinal direction of the manipulation tube through the gel layer in a gel state.

US Pat. No. 9,507,031

RADIATION DETECTOR AND TOMOGRAPHIC EQUIPMENT PROVIDED WITH THE SAME

SHIMADZU CORPORATION, Ky...

1. A radiation detector comprising a scintillator formed of two or more scintillation counter crystals to convert radiation
emitted from a radiation source into fluorescence, and a fluorescence detection device to detect fluorescence from the scintillator,
the radiation detector comprising a first reflector frame in which two or more first reflectors that extend along a first
direction while being arranged in a second direction perpendicular to the first direction and two or more second reflectors
that extend along the second direction while being arranged in the first direction are arranged in a lattice pattern, and
a second reflector frame having two or more reflectors arranged in a lattice pattern as well as the first reflector frame,

the first reflector frame and the second reflector frame being laminated along a third direction that is perpendicular to
the first direction and the second direction,

each of the scintillation counter crystals being inserted in the third direction through the first reflector frame and the
second reflector frame, whereby two or more scintillation counter crystals are arranged in the first direction and the second
direction to form a first scintillation counter crystal layer, and

a position of the first reflector frame provided in the first scintillation counter crystal layer differing from a position
of the second reflector frame provided in the first scintillation counter crystal layer.

US Pat. No. 9,502,228

ION TRAP ANALYZER AND ION TRAP MASS SPECTROMETRY ANALYSIS METHOD

SHIMADZU CORPORATION, Ky...

1. An ion trap analyzer, comprising:
multiple confining electrodes,
an ion trapping space enclosed by the multiple confining electrodes,
a voltage source configured to apply a trapping voltage to at least one confining electrode of the multiple confining electrodes,
so as to generate a trapping electric field in the ion trapping space,

at least one ion ejection outlet provided on a side of the ion trapping space, the ion ejection outlet defining an ion ejection
direction, and

an excitation voltage source,
wherein confining electrodes on the same side of the ion trapping space as the ion ejection outlet are divided into multiple
electrode parts in a direction perpendicular to the ion ejection direction,

wherein the voltage source is further configured to overlay at least one of in-phase alternating trapping voltages or DC trapping
voltages on the multiple electrode parts so as to form a substantially quadratic trapping electric field in the ion ejection
direction, and

wherein the excitation voltage source is configured to overlay an alternating voltage signal whose amplitude is less than
or equal to a maximum absolute value of the trapping voltage on a first electrode part of the multiple electrode parts, the
first electrode part being adjacent to the ion ejection outlet, so as to select a motion range of ions by means of resonant
excitation, and such that no voltage signal having the same phase as said alternating voltage signal is applied on a second
electrode part of the multiple electrode parts except the first electrode part, and

wherein the excitation voltage source is further configured to overlay an alternating voltage signal inverted to the alternating
voltage signal on the second electrode part.

US Pat. No. 9,445,770

NUCLEAR MEDICINE DIAGNOSTIC APPARATUS

Shimadzu Corporation, Ky...

1. A nuclear medicine diagnostic apparatus comprising:
a support unit for supporting an inspection object at one side of a supporting surface of the support unit, the support unit
having an opening for receiving a breast of the inspection object;

a radiation detector disposed on another side of the supporting surface, the other side being an opposite side to the one
side of the supporting surface, for detecting radiation generated from the breast;

a first mat provided on the one side of the supporting surface around the opening for supporting a chest of the inspection
object; and

a second mat provided on the one side of the supporting surface outward of the first mat for supporting the inspection object,
wherein the first mat includes a material having a greater compression rate than the second mat.

US Pat. No. 9,653,275

IONIZATION APPARATUS

SHIMADZU CORPORATION, Ky...

1. An ionization apparatus for ionizing predetermined sample molecules or atoms, the ionization apparatus comprising:
a) an ionization chamber having: an electron introduction port for introducing thermal electrons to an internal space of the
ionization chamber; an electron discharge port for discharging thermal electrons that have passed through the internal space;
and an ion emission port for emitting sample-derived ions produced in the internal space to an outside;

b) a thermal electron source for producing the thermal electrons, the thermal electron source being arranged on an outer side
of the electron introduction port;

c) an electron trapping unit for trapping the thermal electrons discharged through the electron discharge port, the electron
trapping unit being arranged on an outer side of the electron discharge port;

d) a repeller electrode for forming, in the ionization chamber, a repelling electric field that repels the sample-derived
ions produced in the ionization chamber toward the ion emission port, the repeller electrode being arranged inside of the
ionization chamber so as to be opposed to the ion emission port; and

e) an ion focusing electrode for forming, in the ionization chamber, a focusing electric field that focuses the sample-derived
ions produced in the ionization chamber around a central axis of an ion flow formed by repelling the sample-derived ions by
the repelling electric field, the ion focusing electrode being arranged any one or both of between the thermal electron source
and the electron introduction port and between the electron discharge port and the electron trapping unit.

US Pat. No. 9,448,240

HYDROPHILIC THIOL PROBE

SHIMADZU CORPORATION, Ky...

13. A mass spectrometry method for a protein, comprising the steps of:
obtaining a modified protein by reacting a thiol probe for a protein with a protein; and
subjecting the modified protein to mass spectrometry,
wherein the thiol probe for a protein is represented by the following formula (I):

wherein R1 represents a linker group, and R2 represents a substituted amino group, and

wherein the substituted amino group is a group represented by —NHR3, wherein R3 represents a hydrocarbon group or a nitrogen-containing group.

US Pat. No. 9,423,302

SPECTROSCOPIC ANALYSIS DEVICE, SPECTROSCOPIC ANALYSIS METHOD AND PROGRAM FOR SPECTROSCOPIC ANALYSIS DEVICE

SHIMADZU CORPORATION, Ky...

1. A spectroscopic analysis device which separates light which has passed through a sample in an optical path into lights
of different wavelengths by a spectroscope and receives the lights of different wavelengths with respective different light
receiving elements to compute the quantity of light of each wavelength in a light quantity computation unit based on a signal
from each light receiving element, said spectroscopic analysis device comprising:
a stray light ratio computation unit which computes a stray light ratio at a specified wavelength based on a ratio of:
a quantity of light at said specified wavelength computed by said light quantity computation unit in a state where there is
no sample having absorption in said optical path; and

a quantity of light of said specified wavelength computed by said light quantity computation unit when the light is transmitted
through a reference sample having absorption at said specified wavelength; and

a stray light quantity computation unit which computes the stray light quantity at each wavelength through computations based
on a product of the stray light ratio at said specified wavelength, the quantity of light at said specified wavelength computed
by said light quantity computation unit in the state where there is no sample having absorption in said optical path, and
different unique values for each wavelength, the stray light quantity corresponding to a magnitude of stray light.

US Pat. No. 9,360,569

POSITRON CT APPARATUS AND A TIMING CORRECTION METHOD

SHIMADZU CORPORATION, Ky...

1. A positron CT apparatus having a plurality of detectors for detecting radiation released from a positron-emitting radioactive
drug given to a patient, comprising:
a computing device, in connection with a time lag histogram showing a count value distribution of time lag variations for
each pair of detectors which count coincidences of the radiation, for:

(i) selecting a first detector as a reference detector and a second detectors as a count detector which count coincidences,
to obtain a time lag histogram of the first detector and the second detector, and selecting a group of detectors including
the second detector,

(ii) selecting a detector different from the second detector from the group of detectors,
(iii) correcting a time lag histogram of the first detector and the selected different detector using the time lag histogram
of the first detector and the second detector,

(iv) newly selecting a detector, which has not been previously selected, from the group of detectors, and correcting a time
lag histogram of the first detector and the newly selected detector using the time lag histogram of the first detector and
the second detector,

(v) repeating (iv) until all of the detectors in the group of detectors are subjected to (iv), and
repeating (i)-(v) by selecting a new reference detector, a new counter detector and a new group of detectors until all of
the plurality of detectors in the positron CT apparatus are subjected to the selection and correction, the new reference detector
being selected from a previously selected group of detectors; and

a coincidence counting circuit for counting coincidences of the radiation based on the time lag histogram for each pair of
detectors repeatedly corrected by the computing device.

US Pat. No. 9,308,530

REACTION CONTAINER PLATE AND REACTION TREATMENT APPARATUS

SHIMADZU CORPORATION, Ky...

1. A reaction container plate comprising:
a sealed reaction container;
a reaction container channel connected to the reaction container;
a sealed container provided separately from the reaction container;
a sealed container channel connected to the sealed container,
a syringe for sending a liquid;
a switching valve for connecting the syringe to the reaction container channel or the sealed container channel; and
a sealed container air vent channel of which one end is connected to the sealed container.

US Pat. No. 9,228,828

THICKNESS MONITORING DEVICE, ETCHING DEPTH MONITORING DEVICE AND THICKNESS MONITORING METHOD

SHIMADZU CORPORATION, Ky...

1. A thickness monitoring device comprising:
a light source which produces a measurement light having a predetermined wavelength bandwidth;
a detection unit which detects, for each wavelength, interference light of said measurement light reflected from an object
of measurement whereof the thickness changes over time; and

a thickness computation unit which computes the thickness of said object of measurement based on change over time of a plurality
of single-wavelength components of the interference light detected by said detection unit,

wherein the thickness computation includes extracting a value at a predetermined time of each of said plurality of single
wavelengths.

US Pat. No. 9,194,505

FLOW CHANNEL SWITCHING VALVE

SHIMADZU CORPORATION, Ky...

1. A flow channel switching valve comprising:
a housing that has an internal space, and includes connection ports connecting flow channel piping in an outer surface, the
connection ports leading to the internal space through flow channels;

a stator that is provided inside the internal space of the housing, has a plane fixed to the housing to form one wall surface
of the internal space, and is provided with a plurality of connection holes in the plane, the plurality of connection holes
being end portions of the flow channels leading the connection ports to the internal space;

a rotor that is arranged inside the internal space so as to come into contact with the plane of the stator where the connection
holes are provided while keeping liquid tightness, and is provided with a groove in a surface in contact with the stator,
the groove forming a flow channel selectively connecting any one pair of the connection holes;

a rotor drive portion that includes a rotor drive shaft having, at a forefront, a rotor holding portion that holds the rotor,
and is arranged perpendicular to the plane of the stator where the connection holes are provided, the rotor drive portion
rotating the rotor drive shaft to thereby rotate the rotor while sliding the rotor on the stator;

a depressed portion receiving liquid at a position below the rotor inside the housing; and
an opening provided in the housing to guide the liquid received by the depressed portion outside the housing.

US Pat. No. 9,128,073

NEEDLE MOVING DEVICE

SHIMADZU CORPORATION, Ky...

1. A needle moving device comprising:
a performing device which includes
a needle,
a needle driving portion for moving the needle in at least a horizontal plane direction by driving of a motor, and
an encoder provided to the motor to measure a moving distance of the needle based on a rotation number of the motor, and
the performing device outputting a measurement signal produced by the encoder;
an arithmetic processing device connected to the performing device to transmit, to the performing device, a signal for moving
the needle to a position;

a detector provided in the performing device, the detector being configured to detect whether, after the performing device
moves the needle, a needle position after the movement based on the measurement signal from the encoder coincides with the
signal transmitted to the performing device by the arithmetic processing device; and

a determining portion provided in the arithmetic processing device, the determining portion being configured to determine
whether, after the performing device moves the needle, the needle position after the movement based on the measurement signal
from the encoder coincides with a designated position that is inputted into the arithmetic processing device from outside,

wherein the needle moving device is configured to (i) compare the needle position after the movement with the designated position
that is inputted into the arithmetic processing device from outside, and (ii) compare the needle position after the movement
with the signal transmitted to the performing device by the arithmetic processing device, so as to determine whether a fault
in the movement of the needle to the designated position is caused by the performing device or by the signal provided by the
arithmetic processing device to the performing device.

US Pat. No. 9,065,369

MOTOR DRIVING DEVICE AND VACUUM PUMP

Shimadzu Corporation, Ky...

1. A motor driving device comprising:
an inverter for driving a motor, the inverter having a plurality of switching elements;
a first arithmetic section for calculating a rotational speed and a magnetic pole electrical angle of a motor rotor based
on information about motor phase voltage and information about motor phase current;

a driving command generating section for generating a sinusoidal wave driving command based on a difference between the rotational
speed and a target rotational speed and the magnetic pole electrical angle; and

a PWM signal generating section for generating a PWM control signal for controlling an ON/OFF state of the plurality of switching
elements based on the sinusoidal wave driving command, wherein

the first arithmetic section includes
a counter electromotive voltage arithmetic section for calculating a first counter electromotive voltage in a fixed coordinate
?? system based on the information about the motor phase voltage and the information about the motor phase current,

a converting section for receiving the magnetic pole electrical angle through feedback and converting the first counter electromotive
voltage into a second counter electromotive voltage in a rotating coordinate dq system based on the magnetic pole electrical
angle,

a second arithmetic section for calculating a magnetic pole phase error based on the second counter electromotive voltage,
a third arithmetic section for calculating the rotational speed based on at least the information about the motor phase voltage
in the information about the motor phase voltage and the information about the motor phase current, and

a fourth arithmetic section for calculating an integrated value of the rotational speed calculated by the third arithmetic
section, and

the first arithmetic section outputs a sum of the magnetic pole phase error and the integrated value as the magnetic pole
electrical angle.

US Pat. No. 9,063,087

RADIATION DETECTOR SIGNAL PROCESSOR AND RADIATION DETECTOR PROVIDED THEREWITH

SHIMADZU CORPORATION, Ky...

1. A radiation detector signal processor comprising:
a spectrum obtaining device configured to receive detection data from a radiation detector provided with a scintillator and
a plurality of light detecting elements, and configured to obtain an energy spectrum of radiation corresponding to the detection
data for each of the light detecting elements;

a peak value obtaining device configured to obtain a peak value of the energy spectrum for each of the light detecting elements;
and

a variation obtaining device configured to obtain a variation in fluorescence detection intensity among the light detecting
elements in accordance with the peak value and a specified number of light spread, the specified number indicating how the
fluorescence generated in the scintillator spreads spatially until reaching each of the detecting elements.

US Pat. No. 9,054,006

RADIATION DETECTOR WITH DEFECTIVE PIXELS PREVENTION STRUCTURE

SHIMADZU CORPORATION, Ky...

1. A radiation detector comprising:
a matrix substrate arranged two-dimensionally and configured to read out signals from each of detecting elements;
a semiconductor layer configured to generate carriers upon incidence of radiation; and
an electrode layer configured to apply voltage, the matrix substrate, the semiconductor layer, and the electrode layer being
laminated in this order,

the semiconductor layer comprising a center portion with a layer thickness under the electrode layer and a tapered end portion
thinner than the center portion,

the matrix substrate comprising electric wires which cross each other, wherein
a crossing portion where the electric wires cross each other when seen from the semiconductor layer is disposed in a position
covered with the center portion of the semiconductor layer except for a position covered with the end portion.

US Pat. No. 9,588,050

TOTAL NITROGEN MEASUREMENT APPARATUS

SHIMADZU CORPORATION, Ky...

1. A total nitrogen measurement apparatus comprising:
an ultraviolet lamp comprising a light emission section and a holding section for holding a base portion of the light emission
section;

a reaction vessel having a space where the light emission section is to be inserted and a sample water is to be contained
around the light emission section for converting nitrogen compounds in the sample water contained in the reaction vessel into
nitrate ions by oxidative decomposition using ultraviolet rays from the light emission section; and

a measurement section configured to perform absorbance measurement on the sample water including the nitrate ions,
wherein the holding section is arranged at a position which is out of the space of the reaction vessel and is not immersed
in the sample water, and the holding section is formed of a material not including iron.

US Pat. No. 9,537,422

HIGH-FREQUENCY POWER SUPPLY APPARATUS FOR SUPPLYING HIGH-FREQUENCY POWER

SHIMADZU CORPORATION, Ky...

1. A high-frequency power supply, comprising:
a direct current voltage source;
at least one half-bridge drive circuit;
a constant-current conversion circuit, and
a series resonant circuit,
wherein the direct current voltage source controls voltage of the at least one half-bridge drive circuit; the at least one
half-bridge drive circuit comprises at least one pair of semiconductor switching elements, a control terminal of each of the
semiconductor switching elements is connected to a secondary winding of a feedback transformer for switching alternately between
an ON state and an OFF state, wherein the two secondary windings respectively connected to two primary windings of the feedback
transformer with connection to the constant-current conversion circuit, the control terminal of each of the semiconductor
switching elements is directly connected to a capacitor and the secondary winding of the feedback transformer, the semiconductor
switching element is a metal-oxide-semiconductor field-effect transistor (MOSFET), and the capacitor is connected in parallel
with the secondary winding of the transformer between the control terminal and a source terminal of the each of the semiconductor
switching elements;

the series resonant circuit comprises an induction coil, at least one capacitor and primary windings of the transformers connected
in series, and a sum of reactance at a specific resonant frequency ? becomes zero; and

the constant-current conversion circuit is a T-type constant-current conversion circuit or a ?-type constant-current conversion
circuit at the specific resonant frequency ?.

US Pat. No. 9,486,178

RADIATION TOMOGRAPHIC IMAGE GENERATING APPARATUS, AND RADIATION TOMOGRAPHIC IMAGE GENERATING METHOD

SHIMADZU CORPORATION, Ky...

1. A radiation tomographic image generating apparatus comprising:
an actual measurement image reconstruction unit for carrying out image reconstruction of a plurality of actual measurement
projection data acquired from different directions with respect to an inspection object including a high radiation absorber,
to generate an actual measurement reconstruction image;

a high absorber area identifying unit for identifying a high absorber area of the actual measurement projection data from
the actual measurement projection data and the actual measurement reconstruction image, to acquire high absorber area identification
data;

a data replacing unit for carrying out, using the high absorber area identification data, data replacement of the high absorber
area of the actual measurement projection data with data obtained from pixels adjacent the high absorber area, to acquire
replacement projection data;

a replacement image reconstruction unit for carrying out image reconstruction of the replacement projection data to generate
a replacement reconstruction image;

a difference processing unit for determining a difference between the actual measurement projection data and the replacement
projection data to acquire difference projection data;

a difference image reconstruction unit for carrying out image reconstruction of the difference projection data to generate
a difference reconstruction image; and

a composite image generating unit for generating a composite reconstruction image by selecting at least one image from among
the actual measurement reconstruction image, the replacement reconstruction image and the difference reconstruction image
on an area-by-area basis.

US Pat. No. 9,453,825

CHROMATOGRAM PEAK PURITY DETERMINATION APPARATUS

SHIMADZU CORPORATION, Ky...

1. A chromatogram peak purity determination apparatus for use in a data processing apparatus for chromatographs, which use
photodiode array detector as a detector for collecting 3-dimensional data whose dimensions consist of retention time, wavelength
and absorbance, for determining the purity of a peak that exists in a chromatogram that is prepared based on said 3-dimensional
data and comprising:
a) an absorbance accumulation means for accumulating, at each retention time, absorbance in the wavelength direction for all
or a part of a wavelength range in a predetermined retention time range;

b) an equal absorbance accumulation value group extracting means for extracting a plurality of groups wherein, for each group,
the absorbance accumulation value is the same for one point on a rising slope and one point on a falling slope with respect
to a peak that exists on a chromatogram that is prepared based on a 2-dimensional data whose dimensions are said absorbance
accumulation value and retention time;

c) a similarity calculation means for calculating similarity between absorption spectrum pattern at one point on the rising
slope and absorption spectrum pattern at one point on the falling slope for each group that is extracted by said equal absorbance
accumulation value group extracting means; and

d) a determination means for determining, with respect to the plurality of groups that are extracted by said absorbance accumulation
value group extracting means, whether or not said peak consists of a single component based on similarity that is calculated
by said similarity calculation means.

US Pat. No. 9,435,777

ANALYZING SYSTEM AND CONTROL METHOD THEREOF

SHIMADZU CORPORATION, Ky...

1. An analyzing system comprising:
a plurality of units for operating to analyze a sample;
a condition setting device for setting a condition regarding operations of the plurality of units; and
a control device capable of performing transmission/reception of data with the plurality of units and the condition setting
device, the control device being for controlling the plurality of units according to the condition set by the condition setting
device,

wherein the plurality of units include operation sections allowing setting of conditions regarding operations of respective
units, and

setting of a condition using the operation section is restricted at least when transmission/reception of data is being performed
between the condition setting device and the control device.

US Pat. No. 9,429,543

ION MOBILITY ANALYZER, COMBINATION DEVICE THEREOF, AND ION MOBILITY ANALYSIS METHOD

SHIMADZU CORPORATION, Ky...

1. An ion mobility analyzer, comprising:
an electrode system around an analytical space; and
a first power supply adapted to apply voltages to the electrode system for forming a moving drift electric field in at least
a portion of the analytical space along an axis, such that specific analyte ions are always in and have the same moving direction
as that of the drift electric field during ion mobility analysis, wherein radio frequency voltages for radial ion confinement
are not applied for at least one portion of the analysis time in order to avoid damage on resolution of ion mobility separation
through heating by the radio frequency voltages.

US Pat. No. 9,429,505

PARTICLE SIZE DISTRIBUTION MEASURING APPARATUS

SHIMADZU CORPORATION, Ky...

1. A particle size distribution measuring apparatus, comprising:
a light source unit for emitting a parallel light beam;
a condensing lens for condensing scattered;
a photodetector for detecting the distribution of light intensity of the scattered light that has been condensed by said condensing
lens;

a cell base, on which a cell that contains an object to be measured including a group of particles to be measured is placed,
located between said light source unit and said condensing lens; and

a control unit for calculating the distribution of particle size of the group of particles to be measured included in said
object to be measured by allowing said photodetector to detect the scattered light generated by irradiating said object to
be measured with a parallel light beam from said light source unit after being condensed by said condensing lens, characterized
in that

a detecting surface for adjusting the optical axis is formed on said photodetector, and
wherein the particle size distribution measuring apparatus further comprises:
a lens for adjusting the optical axis which is placed between said light source unit and said cell base unit and which has
an entrance plane through which a parallel light beam from said light source unit enters and an exit plane that is not parallel
to the entrance plane; and

a lens drive mechanism that can rotate said lens for adjusting the optical axis so that the angle at which a parallel light
beam from said light source unit enters into said entrance plane can be changed; and

wherein the detecting surface of said photodetector is placed parallel to the YZ plane in the case wherein the direction along
a line connecting said light source unit to said photo detector is the X direction, one direction perpendicular the X direction
is the Y direction, and the direction perpendicular to the X and Y directions is the Z direction,

wherein said lens for adjusting the optical axis comprises a first lens of which the angle between the entrance plane and
the exit plane is a first predetermined angle as viewed from the Y direction and a second lens of which the angle between
the entrance plane and the exit plane is a second predetermined angle as viewed from the Z direction, and

wherein said lens drive mechanism makes it possible for said first lens to be rotated around an axis in the Y direction and
for said second lens to be rotated around an axis in the Z direction.

US Pat. No. 9,347,919

GAS-LIQUID CONTACT EXTRACTION METHOD AND APPARATUS

Shimadzu Corporation, (J...

11. A gas-liquid contact extraction method using a gas-liquid contact extractor to which a sample liquid is continuously introduced
from above and a purge gas from beneath, for extracting an analyte in the sample liquid by gas-liquid contact between the
sample liquid and the purge gas, the method comprising discharging the sample liquid through a liquid sump provided to a discharge
pipe connected to a bottom of the gas-liquid contact extractor, while blocking outflow of the purge gas from the liquid sump,
wherein the gas-liquid contact extractor is provided in a temperature-controlled oven, and a temperature of a flow channel
to a collection tube for condensing the gas-liquid contact extracted analyte is set to a temperature equal to or higher than
an oven temperature (gas-liquid extraction temperature), so that the gas-liquid extracted analyte is condensed in the collection
tube.

US Pat. No. 9,301,728

X-RAY APPARATUS

SHIMADZU CORPORATION, Ky...

1. An X-ray apparatus configured to obtain a reference mask image of a subject and a live image of the subject which includes
information to be examined and is different from the reference mask image, and extract the information from the live image
based on the reference mask image, the X-ray apparatus comprising:
an X-ray irradiating device for irradiating a subject with X-rays;
an X-ray detector for detecting X-rays transmitting through the subject;
an imaging-condition setting section for setting X-ray imaging conditions for the X-ray irradiating device to irradiate the
subject with the X-rays;

a mask-image taking time calculating section for
(i) setting a first imaging time for obtaining a first mask image of the subject, in accordance with the X-ray imaging conditions,
and

(ii) calculating a second imaging time for obtaining a mask image of the subject to be taken subsequent to the first mask
image in accordance with imaging time and brightness of a mask image taken previously such that average brightness of the
mask image taken previously and a mask image to be taken next is target brightness;

a live-image taking time calculating section for calculating an imaging time for the live image in accordance with an imaging
time of the mask image to which X-rays are emitted from the X-ray irradiating device based on the first imaging time and an
imaging time of the mask image to which X-rays are emitted from the X-ray irradiating device based on the second imaging time;
and

an image processor for receiving detection signals of the X-rays detected by the X-ray detector and calculating a subtraction
image based on a difference between the reference mask image and the live image, the reference mask image being obtained through
averaging the mask image taken in accordance with the first imaging time and the mask image taken in accordance with the second
imaging time.

US Pat. No. 9,232,627

RADIO-FREQUENCY OSCILLATION CIRCUIT

SHIMADZU CORPORATION, Ky...

1. A self-oscillating radio-frequency oscillation circuit, comprising: a DC voltage source; an LC resonance circuit including
a coil and a capacitor; a switching circuit including a switching element for switching a DC power supplied from the DC voltage
source and for supplying the power to the LC resonance circuit; and a transformer formed by a primary winding included in
the LC resonance circuit and a secondary winding connected to a control terminal of the switching element so as to turn on
and off this switching element, the radio-frequency oscillation circuit further comprising:
a) a starting transformer having a secondary winding connected inside the LC resonance circuit; and
b) a starter for supplying a primary winding of the starting transformer with a radio-frequency current whose frequency is
close to a resonant frequency of the LC resonance circuit during a certain period of time in a starting phase, so as to start
a self-oscillation in the radio-frequency oscillation circuit.

US Pat. No. 9,159,544

MASS ANALYSER AND METHOD OF MASS ANALYSIS

SHIMADZU CORPORATION, Ky...

1. An electrostatic ion trap for mass analysis comprising: a first array of electrodes and a second array of electrodes, spaced
from the first array of electrodes, voltage being supplied, in use, to electrodes of the first and second arrays of electrodes
to create an electrostatic field in the space between the electrode arrays, wherein electrodes of the first array and electrodes
of the second array are supplied, in use, with substantially the same pattern of voltage, whereby the distribution of electrical
potential in said space is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory
motion in said space, focused substantially mid-way between said first and second arrays, and
wherein at least one electrode of said arrays is connected to amplifier circuitry for detection of image current having frequency
components related to the mass-to-charge ratio of ions undergoing said periodic oscillatory motion in said space between the
first and second arrays of electrodes and

wherein said first and second arrays of electrodes each comprise concentric, circular or part-circular electrically conductive
rings, and further including a full, or part-toroidal ion trap, or ion guide injector extending around said electrically conductive
rings for respectively temporarily storing or guiding ions and then pulsing the ions radially inwards into said space between
the first and second arrays of electrodes.

US Pat. No. 9,125,626

LIGHT MEASUREMENT DEVICE

Shimadzu Corporation, Ky...

1. A light measurement device for obtaining measurement data that shows change over time in hemoglobin concentration while
a subject is performing a load during a task period, said light measurement device comprising:
a light transmission/reception unit comprising light transmission probes arranged to be positioned on the surface of a scalp
of said subject and light reception probes arranged to be positioned on the surface of said scalp;

a light transmission/reception unit controller for obtaining received light amount information regarding measurement sites
of a brain of said subject by controlling so that said light transmission probes emit light to the scalp surface and said
light reception probes detect light that emerges from the scalp surface;

a calculation unit for calculating the change in hemoglobin concentration based on said received light amount information;
a biomonitor arranged to be positioned on the skin surface of said subject for detecting biological information related to
heart rate, blood pressure or respiration of said subject;

a biomonitor controller for obtaining biological information from said biomonitor; and
a task period start time determination unit for determining a starting time for said task period based on said biological
information.

US Pat. No. 9,103,810

SEALING STRUCTURE FOR LIQUID PASSAGE CONNECTION PART

Shimadzu Corporation, Ky...

1. A sealing structure, including:
a) a sealing member having a through-hole for allowing a passage of a sample;
b) a housing having a cavity for holding the sealing member, the cavity having a sample introduction hole at a bottom thereof,
the sample introduction hole communicating with the through-hole; and

c) a pressure device for pressing the entire sealing member from an opening of the cavity toward the bottom of the cavity,
wherein the cavity is shaped so that the wall surface of the cavity fits with the external shape of the sealing member in
pressure-free state from the opening of the cavity to a predetermined depth thereof while a space is left between the wall
surface of the cavity and the external shape of the sealing member in pressure-free state at and around the bottom of the
cavity from the aforementioned depth.

US Pat. No. 9,075,073

COMPOUND-ANALYZING METHOD, COMPOUND ANALYZER AND COMPUTER READABLE MEDIUM RECORDING A COMPOUND-ANALYZING PROGRAM

SHIMADZU CORPORATION, Ky...

1. A compound-analyzing method for detecting a cathinone-based compound having cathinone as a basic skeleton and for estimating
a structure of the cathinone-based compound, using a chromatograph mass spectrometer capable of an MS/MS measurement, the
compound-analyzing method comprising:
a) a measurement execution step, in which a sample which contains or possibly contains a compound which is an analysis target
is separated into components by a chromatograph and two or three kinds of MS/MS measurements are repeatedly performed on the
sample, the two or three kinds of measurements including:

a1) one or both of following two kinds of measurements: an MRM measurement, in which a benzoyl part produced by ?-cleavage
during an ionization process is selected as a precursor ion, a benzene part produced by dissociation of a carbonyl group from
the benzoyl part is selected as a product ion, and a plurality of MRM transitions corresponding to possible values of a mass
of a third functional group bonded to a benzene ring are specified as measurement conditions; and a second product-ion scan
measurement performed for a benzoyl part produced by ?-cleavage during an ionization process, in which each of a plurality
of kinds of benzoyl parts corresponding to the possible mass values of the third functional group is selected as a precursor
ion; and

a2) a first product-ion scan measurement performed for an amine part produced by ?-cleavage during an ionization process,
in which each of a plurality of kinds of amine parts corresponding to possible values of a total mass of a first functional
group and a second functional group respectively bonded to different sites on the amine part is selected as a precursor ion;

b) a compound presence checking step, in which a presence of a cathinone-based compound is judged by determining whether or
not a common peak exists at a same retention time on chromatograms respectively corresponding to the two or three kinds of
measurements, the chromatograms being created based on data respectively obtained by the MRM measurement and/or the second
product-ion scan measurement as well as the first product-ion scan measurement; and

c) a structure estimation step, in which a kind of the third functional group is estimated based on the data obtained by the
MRM measurement and/or the second product-ion scan measurement, kinds of the first functional group and the second functional
group are estimated based on the data obtained by the first product-ion scan measurement, and results of these estimations
are combined to estimate a structure of a cathinone-based compound whose presence is confirmed in the compound presence checking
step.

US Pat. No. 9,075,782

MASS SPECTROMETRY DATA ANALYSIS METHOD AND ANALYSIS DEVICE

SHIMADZU CORPORATION, Ky...

1. A mass spectrometry data analysis method for analyzing data collected by executing mass spectrometry on each of a plurality
of micro areas set in a two-dimensional region of a sample by a mass spectrometry device, the method comprising:
a) a peak detection step in which peak information including the intensities and mass/charge ratios of peaks is collected
by executing peak detection processing on mass spectrum data obtained for each of said plurality of micro areas by a processor;

b) an intensity standardization step in which the peak information for each micro area obtained in said peak detection step
is collected and the intensity values of each micro area are standardized so that the spatial intensity distributions can
be compared for each mass/charge ratio for all of the peaks by the processor;

c) a clustering execution step in which the mass/charge ratios that are made to correspond to the spatial intensity distributions
are classified into a prescribed number of clusters by using the clustering of the spatial intensity distributions of each
mass/charge ratio after standardization by said intensity standardization step by the processor; and

d) an identification step in which the mass/charge ratios of ions derived from the same substance are identified using at
least differences in a plurality of mass/charge ratios classified into the same cluster by the processor.

US Pat. No. 9,068,932

SPECTROPHOTOMETER

Shimadzu Corporation, Ky...

1. A spectrophotometer comprising:
a specimen cell;
a light source unit for emitting measurement light to said specimen cell;
a photodetector for detecting measurement light that has passed through said specimen cell;
a memory unit for storing output strength signals obtained by said photodetector; and
a control unit for calculating transmittance or absorbance based on the output strength signal (S) that is stored in said
memory unit; wherein:

said controller calculates the true output strength signal (sN) of the Nth period removed of the effects of output strength signals (SN?1, SN?2, SN?3, . . . ) of the incidence duration of the (N?1)th period and earlier that are included in the output strength signal (SN) of the incidence duration of the Nth period.

US Pat. No. 9,065,309

MAGNETIC LEVITATION TYPE VACUUM PUMP AND MAGNETIC LEVITATION DEVICE

SHIMADZU CORPORATION, Ky...

1. A magnetic levitation type vacuum pump, comprising:
a rotor in which an exhausting unit is formed;
a motor, rotationally driving the rotor;
an electromagnet, magnetically levitating the rotor by a magnetic force and an electromagnet coil wound around a core;
an electromagnet driving circuit, supplying an electromagnet current to the electromagnet coil, wherein the electromagnet
current comprises a magnetic levitation control current component for magnetically levitating the rotor and a carrier wave
current component having a frequency band higher than that of the magnetic levitation control current component and for detecting
a levitated position of the rotor;

a levitated position detecting circuit, detecting the carrier wave current component and generating a levitated position signal
of the rotor;

a magnetic levitation control circuit, inputting a current command of the magnetic levitation control current component to
the electromagnet driving circuit based on the levitated position signal;

wherein the electromagnet coil has a primary coil and a secondary coil connected in parallel with the primary coil, and
an interrupting circuit connected in series with the secondary coil, the carrier wave current component passing therethrough
and interrupting the magnetic levitation control current component.

US Pat. No. 9,691,598

IONIZER AND MASS SPECTROMETER INCLUDING FIRST SECTION FOR IONIZING SAMPLE UNDER ATMOSPHERIC PRESSURE WHILE VAPORIZING OR DESORBING THE SAMPLE COMPONENT AND SECOND SECTION FOR GENERATING CORONA DISCHARGE

SHIMADZU CORPORATION, Ky...

1. An ionizer for producing a sample-derived ion under atmospheric pressure and for introducing the ion through an ion introduction
opening into a subsequent section maintained at a lower gas pressure, the ionizer comprising:
a) a first ionization section for ionizing a sample component in a solid or liquid sample under atmospheric pressure while
vaporizing or desorbing the sample component; and

b) a second ionization section located in an area through which gaseous molecules containing ions produced by the first ionization
section travel to the ion introduction opening, the second ionization section including a needle electrode with a tip portion
having a curved surface, the ion introduction opening being formed within another electrode, an ionization condition regulator
for adjusting a position and/or an angle of the needle electrode relative to the other electrode within which the ion introduction
opening is formed, and a voltage supplier for applying a voltage to the needle electrode, wherein the second ionization section
generates a corona discharge by applying the voltage from the voltage supplier to the needle electrode irrespective of the
position and/or the angle of the needle electrode relative to the ion introduction opening, the corona discharge between the
needle electrode and the other electrode producing a reactant ion by ionizing an atmospheric component or solvent molecule,
and the reactant ion ionizing a sample molecule by reacting with the sample molecule.

US Pat. No. 9,478,014

IMAGE PROCESSING METHOD FOR EXTRACTING LINEAR PATTERNS

SHIMADZU CORPORATION, Ky...

1. An image processing method comprising the steps of:
generating an evaluation image used for evaluating for each of pixels whether or not a pixel belongs to a linear configuration
in an original image;

generating a direction image based on the original image, the direction image indicating a direction of pixels corresponding
to the linear configuration in the original image;

generating a difference image based on the direction image, the difference image being obtained by subtracting pixel values
other than the linear configuration from pixel values of the linear configuration in the original image;

generating an extraction image with the linear configuration in the original image extracted therefrom based on the evaluation
image and the difference image; and

connecting fragments of the linear configuration in the extracted image to generate a fragment eliminated image by obtaining
an extending direction of the linear configuration based on the direction image, determining a start point pixel and an end
point pixel arranged in the extending direction in the extraction image, and interpolating between the two pixels.

US Pat. No. 9,470,235

VACUUM PUMP

Shimadzu Corporation, Ky...

1. A vacuum pump comprising:
an exhaust portion having a plurality of rotating blade portions arranged in multiple stages, each of the rotating blade portions
having a plurality of rotor blades, and a plurality of stationary blade portions arranged between the rotating blade portions,
in which outer circumferential rims are supported via spacers, each of the stationary blade portions having a plurality of
stator blades, wherein

in at least one stationary blade portion among the plurality of stationary blade portions, a blade height on the inner circumferential
side of the plurality of stator blades provided in the stationary blade portion is set to be smaller than a blade height on
the outer circumferential side of the plurality of stator blades, and

in the at least one stationary blade portion the gap between the upper surface of the stationary blade portion on the inner
circumferential side and the lower surface of the rotating blade portion on the upper stage side is larger than the gap between
the lower surface of the stationary blade portion on the inner circumferential side and the upper surface of the rotating
blade portion on the lower stage side, the stationary blade portion is supported by the spacers in such a manner that the
inner circumferential side of the stationary blade portion is floated up toward an intake port side.

US Pat. No. 9,460,901

DATA-PROCESSING SYSTEM FOR CHROMATOGRAPH MASS SPECTROMETRY

SHIMADZU CORPORATION, Ky...

1. A data-processing system for chromatographic mass spectrometry for creating a chromatogram by processing data repeatedly
collected by a chromatograph quadrupole mass spectrometer capable of setting a mass spectrometric measurement condition for
each of segments corresponding to a plurality of time ranges continuously or discontinuously set on a time axis, comprising:
a) a memory for storing a parameter value specified as a mass spectrometric measurement condition for each of the segments;
b) a determiner for retrieving, from the memory, a predetermined parameter value for each of a pair of continuously located
segments, and for determining whether the retrieved parameter values are identical; and

c) a chromatogram creation processor for creating a chromatogram by connecting partial chromatograms based on the data collected
for each of the aforementioned pair of segments under the corresponding measurement condition, when the determiner has determined
that the retrieved parameter values are identical.

US Pat. No. 9,400,245

DRIFT CALCULATION DEVICE AND LIGHT DETECTION DEVICE PROVIDED WITH THE SAME

SHIMADZU CORPORATION, Ky...

1. A drift calculation device for calculating a drift based on measurement intensity that is input at a predetermined cycle,
the drift calculation device comprising:
a plurality of sum buffers assigned respectively to a plurality of following sum functions that take as a variable, with respect
to a coefficient included in a following calculation formula for calculating the drift by using a least squares method, at
least one of measurement intensity and measurement time forming the coefficient;


wherein x1 is the measurement time, v1 is measurement intensity;

a data update unit for updating, every time the measurement intensity is input according to the predetermined cycle, data
in the plurality of sum buffers based on at least one of the measurement intensity and the measurement time at the time; and

a drift calculation unit for calculating the drift by substituting the data in the plurality of sum buffers updated by the
data update unit in the calculation formula.

US Pat. No. 9,347,489

MAGNETIC BEARING DEVICE AND VACUUM PUMP

Shimadzu Corporation, Ky...

1. A magnetic bearing device for supporting a body to be supported using an electromagnet in a non-contact manner, comprising:
a sine wave discrete value generating section for generating a sine wave discrete value by a digital arithmetic process;
a carrier wave generating section for generating a carrier wave signal based on the sine wave discrete value;
a displacement detecting section for modulating the carrier wave signal depending on a supporting position of the body to
be supported so as to output a modulation wave signal;

an AD converting section for AD-converting the modulation wave signal into a digital signal at a sampling frequency fs that
satisfies fc=(n+½)·fs (n is an integer of not less than 0) and at a predetermined timing that synchronizes with the sine wave
discrete value when a frequency of the carrier wave signal is denoted by fc;

a demodulation arithmetic section for performing demodulation arithmetic based on the AD-converted digital signal; and
a controller for controlling a current of the electromagnet based on a demodulation calculated result of the demodulation
arithmetic section so as to control the supporting position of the body to be supported, wherein

the predetermined timing is a timing at which the sampling timing is in a vicinity of a maximum peak position of the carrier
wave signal and a timing at which the sampling timing is in a vicinity of a minimum peak position, and

the demodulation arithmetic section outputs, as the demodulation calculated result, a value d3 calculated with d3=(d1?d2)/2
when a data value of the digital signal sampled in the vicinity of the maximum peak position is denoted by d1 and a data value
of the digital signal sampled in the vicinity of the minimum peak position is denoted by d2.

US Pat. No. 9,316,625

MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer having: an ion source for ionizing a component in a sample; a mass analyzer for separating ions generated
by the ion source according to their mass-to-charge ratios; and an ion detector for detecting the ions separated by the mass
analyzer, the ion detector having a conversion dynode for converting ions into electrons and a secondary electron multiplier
for multiplying and detecting the electrons, the mass spectrometer comprising:
a) a voltage supplier for applying high voltage to the conversion dynode, where the high voltage is independent from a voltage
applied to other components of the mass spectrometer;

b) an analysis executer for changing the voltage applied to the conversion dynode by the voltage supplier to a plurality of
levels, and for obtaining, for every change in the voltage applied to the conversion dynode, a noise signal under an analysis
condition at that point in time and a detection signal corresponding to an ion originating from a target component; and

c) an optimum voltage setter for calculating an SN ratio based on the noise signal and the detection signal obtained by the
analysis executer for each different level of the applied voltage, and for determining, based on the calculated result, the
voltage to be applied to the conversion dynode in an analysis of the target component.

US Pat. No. 9,255,742

SAMPLE COOLING DEVICE AND SAMPLING APPARATUS

SHIMADZU CORPORATION, Ky...

1. A sample cooling device for cooling a sample container held in a heat conductive rack, the sample cooling device comprising:
a cooler;
a heat conductive member having an upper surface configured to support a rack thereon, said heat conductive member being in
contact with the cooler such as to be cooled by said cooler; and

a heat conductive water absorbing member disposed at least partly in a region defined between the upper surface of the heat
conductive member and a rack position and configured such as to be in contact with both of the heat conductive member and
a rack positioned in said rack position, the water absorbing member having a structure for absorbing water by a capillary
force,

wherein the water absorbing member is a porous member provided with a plurality of pores, each having an inner diameter enough
to allow a capillary force to act.

US Pat. No. 9,224,225

MASS SPECTROMETRY DATA PROCESSING DEVICE

SHIMADZU CORPORATION, Ky...

1. A mass spectrometry data processing device which processes and displays, on a display screen, data collected by comparing
peaks appearing in an MSm?1 spectrum, obtained by performing MSm?1 analysis (2?m?n) over time, to predetermined precursor selection parameters and automatically selecting a precursor ion and
performing MSm analysis by means of a chromatograph-mass spectrometer combining a chromatograph and a mass spectrometer capable of MSn analysis (where n is an integer equal to or greater than 2), which mass spectrometry data processing device processes data
under conditions wherein excluded ions which are not to be selected as precursor ions and priority ions which are to be preferentially
selected as precursor ions regardless of other conditions, have been stipulated as one of said precursor selection parameters,
the mass spectrometry data processing device comprising:
a) a spectrum display processing means which displays an MSm?1 spectrum for an arbitrary retention time designated by the user and an MSm spectrum for a precursor ion selected based on said MSm?1 spectrum next to each other on the same screen;

b) an information collection means which collects information relating to excluded ions and priority ions corresponding to
the retention time of the MSm?1 spectrum and MSm spectrum displayed by said spectrum display processing means; and

c) an additional display processing means which graphically displays, over the MSm?1 spectrum displayed by said spectrum display processing means, the mass-charge ratio or mass-charge ratio range of excluded
ions and priority ions at the retention time of said spectrum, collected by said information collection means.

US Pat. No. 9,188,572

LIQUID CHROMATOGRAPHY ANALYZING DEVICE

Shimadzu Corporation, Ky...

1. A liquid chromatograph analyzing device comprising:
an analysis flow path through which a mobile phase for transporting a sample flows;
a sample injection section for injecting a sample into said analysis flow path;
a separation column disposed in said analysis flow path at a position downstream of said sample injection section and for
separating into individual components a sample that is injected from said sample injection section;

a detection device disposed in said analysis flow path at a position further downstream of said separation column and for
detecting individual components separated by said separation column;

a computation section for creating a chromatogram of a sample based on detection signals obtained by said detection device;
a correction parameter holding section for holding, as correction parameters, measurement environmental conditions that affect
a chromatogram; and

a correction formula setting unit for setting correction formulas for reflecting said correction parameters in a chromatogram;
wherein:
said computation section successively obtains detection signals that are obtained by said detection device and, at the same
time, obtains correction parameters corresponding to said detection signals from said correction parameter holding section
and successively creates chromatograms that reflect the obtained correction parameters based on the correction formulas that
are set by said correction formula setting unit.

US Pat. No. 9,123,515

ION MOBILITY SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. An ion mobility spectrometer comprising an ionization section which generates ions derived from sample components, a drift
region which causes the ions generated in the ionization section to move such that they separate according to mobility, and
a shutter gate grid for extracting the ions in short pulses and feeding them to said drift region,
characterized in that said shutter gate grid comprises:
a first conductive disc-shaped member wherein multiple conductive wires are secured in parallel in a central opening and multiple
threaded holes are formed in the periphery; a second conductive disc-shaped member wherein multiple conductive wires are secured
in parallel in a central opening and multiple fan-shaped screw insertion holes are formed in the periphery; and an insulation
sheet member which has a central opening and multiple screw insertion holes formed in the periphery,

wherein, in a state where said insulation sheet has been sandwiched between said first conductive disc-shaped member and said
second conductive disc-shaped member, these members are integrally joined by means of a plurality of screws having electrical
insulative characteristics, which are inserted in sequence through the fan-shaped screw insertion holes of said second conductive
disc-shaped member, the screw insertion holes of said insulation sheet member, and into the threaded holes of said first conductive
disc-shaped member.

US Pat. No. 9,086,491

RADIATION TOMOGRAPHY APPARATUS

SHIMADZU CORPORATION, Ky...

1. A radiation tomography apparatus, comprising:
a plurality of radiation detectors; and
a plurality of modules, wherein
the modules are connected to the radiation detectors respectively, and are connected to one another, and
the modules send and receive detected data outputted from the radiation detectors mutually, thereby sharing the detected data
and counting the number of coincidence events.

US Pat. No. 9,589,174

IMAGING MASS SPECTROMETER AND MASS SPECTROMETRY DATA PROCESSING METHOD

Shimadzu Corporation, Ky...

1. A mass spectrometry data processing method, said method comprising:
generating mass spectrometry data that is obtained from each of a plurality of micro-regions that are set within a predetermined
two-dimensional area on a specimen;

extracting specific sites from microscopy images, which are obtained by labeling specific sites in said two-dimensional area
or a portion thereof with a visualization marker;

categorizing each of said micro-regions into a plurality of clusters based on similarity/dissimilarity of mass spectrometry
data for each of the micro-regions so that micro-regions of high similarity belong to the same cluster; and

determining the total number of clusters based on the results of a comparison between the spatial distribution of the specific
sites that are extracted and the spatial distribution of all micro-regions that belong to one of the plurality of clusters
into which each of said micro-regions are classified.

US Pat. No. 9,508,765

PHOTODIODE ARRAY DETECTOR WITH DIFFERENT CHARGE ACCUMULATION TIME FOR EACH LIGHT RECEIVING ELEMENT WITHIN ONE UNIT

SHIMADZU CORPORATION, Ky...

1. A photodiode array detector used for detecting light which has undergone wavelength separation by a spectroscopic element,
said photodiode array detector comprising:
a) a light receiving element array wherein, taking a plurality of light receiving elements which detect light of the same
wavelength range as one unit, a plurality of such units are arrayed in a wavelength dispersion direction; and

b) a charge accumulation time setting unit which sets a different charge accumulation time for each of the plurality of light
receiving elements within said one unit.

US Pat. No. 9,506,475

SENSORLESS MAGNETIC LEVITATION VACUUM PUMP AND SENSORLESS MAGNETIC LEVITATION DEVICE

Shimadzu Corporation, Ky...

1. A sensorless magnetic levitation vacuum pump comprising:
a rotor provided with an exhaust function unit;
a motor for rotating the rotor;
an electromagnet for magnetically levitating the rotor using magnetic force;
an electromagnet drive circuit for supplying, to the electromagnet, an electromagnet current including a magnetic levitation
control current component for magnetically levitating the rotor and a carrier current component for detecting a levitation
position of the rotor, the carrier current component having a higher frequency band than the magnetic levitation control current
component;

a levitation position detecting circuit for detecting the carrier current component to generate a levitation position signal
of the rotor; and

a magnetic levitation control circuit for inputting a current command of the magnetic levitation control current component
to the electromagnet drive circuit based on the levitation position signal, wherein

the electromagnet comprises a core having a pair of magnetic poles; a primary coil wound around the core; and a series circuit
of a first secondary coil wound around the first one of the magnetic poles of the core, a second secondary coil wound around
the second one of the magnetic poles of the core, and a capacitor, the primary coil and the series circuit being connected
in parallel, and

each of the first and second magnetic poles is divided into a plurality of divided magnetic poles, the first secondary coil
comprising a plurality of split secondary coils wound around the plurality of divided magnetic poles, respectively, of the
first magnetic pole so that the mutual inductance with the primary coil becomes zero, and the second secondary coil comprising
a plurality of split secondary coils wound around the plurality of divided magnetic poles, respectively, of the second magnetic
pole so that the mutual inductance with the primary coil becomes zero.

US Pat. No. 9,354,108

ELECTRONIC BALANCE

SHIMADZU CORPORATION, Ky...

1. An electronic balance, comprising:
a scale pan;
a load detector for supporting said scale pan and outputting the load value of a load placed on said scale pan; and
a weight change calculator configured to calculate changes in the weight of a sample to be measured based on:
sample load measurement values outputted from said load detector when said sample is placed on said scale pan at two different
points in time;

reference weight load measurement values outputted from said load detector when a reference weight is placed on said scale
pan before and after said respective sample load measurement values are outputted; and

load-free measurement values outputted from said load detector in the load-free state before and after each of said sample
load measurement values is outputted and before and after each of said reference weight load measurement values is outputted.

US Pat. No. 9,348,033

POSITRON CT APPARATUS

SHIMADZU CORPORATION, Ky...

1. A positron computed tomography (CT) apparatus for detecting gamma rays released from a patient, comprising:
a first detecting device for detecting gamma rays around a first site of interest of the patient;
a second detecting device for detecting gamma rays, which is disposed separately across part of the first site of interest
and a second site of interest spaced from an imaging area of the first detecting device;

a first image processing device for producing an Radio Isotope (RI) distribution image from coincidence data obtained from
the first detecting device;

a second image processing device for producing a real planar image corresponding to gamma rays released in a predetermined
projecting direction, based on coincidence data obtained from the second detecting device;

a calculated planar image calculating device for calculating, based on the RI distribution image produced, a calculated planar
image of a time when the imaging area of the first detecting device is projected in the same direction as the projecting direction;
and

a correcting device for subtracting the calculated planar image from the real planar image.

US Pat. No. 9,269,558

MS/MS TYPE MASS SPECTROMETER AND PROGRAM THEREFOR

SHIMADZU CORPORATION, Ky...

1. An MS/MS type mass spectrometer, comprising:
a first mass separator, selecting, from various kinds of ions, a product ion having a specific mass-to-charge ratio as a precursor
ion;

an ion fragmentation unit, subjecting the precursor ion to fragmentation;
a second mass separator, selecting a product ion having a specific mass-to-charge ratio from various kinds of product ions
generated by the fragmentation;

a detector, detecting the product ion selected by the second mass separator; and
a control unit, controlling the first mass separator, the ion fragmentation unit, the second mass separator and the detector
to execute an analysis, and analyzing data resulting from the executed analysis,

wherein the control unit further comprises:
an event preparation unit, preparing, with respect to the precursor ion of a certain component, a plurality of product ion
scan events among product ion scan events with conditions of at least one of the ion fragmentation unit and the second mass
separator being changed as well as product ion scan events without the conditions being changed;

an event execution unit, executing the prepared plurality of product ion scan events; and
a detecting unit, detecting a mass peak with the highest appearance frequency from all mass spectra generated by all the executed
product ion scan events,

wherein the mass peak with the highest appearance frequency is selected determined to be an optimum product ion peak of the
precursor ion by the control unit.

US Pat. No. 9,230,784

MASS SPECTROMETER AND MASS SPECTROMETRY METHOD

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer in which sample components separated by a liquid chromatograph are ionized, and the obtained ions are
cleaved and subjected to mass spectrometry to perform MSn analysis (n is an integer of 3 or greater), the mass spectrometer comprising:
a MS measurement processing section configured to measure a MS spectrum which represents a relation of a mass-to-charge ratio
and an intensity by performing mass spectrometry of the ionized sample components;

an ion detection processing section configured to detect, as a MS/MS precursor ion, an ion, the intensity distribution of
which forms a peak waveform at both of each retention time and each mass-to-charge ratio, based on three-dimensional information
of a retention time, a mass-to-charge ratio and an intensity, which is obtained by correlating the MS spectrum with the retention
time;

an overlap determination processing section configured to determine whether or not isotopic distributions of a plurality of
ions detected as MS/MS precursor ions have overlapping m/z ranges at each retention time; and

an execution determination processing section configured to determine whether or not MS3 analysis is performed for each ion detected as a MS/MS precursor ion, based on the result of determination by the overlap
determination processing section.

US Pat. No. 9,218,948

MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer equipped with an ion transport optical element between an ion source and a detector, and provided with
an adjustment function to optimize a voltage applied to the ion transport optical element based on a result of mass spectrometry
of a predetermined component in a sample, comprising:
a) voltage application means for changing a value of voltage applied to the ion transport optical element stepwise at a predetermined
step size, and for changing the step size according to the value of voltage; and

b) optimum voltage searching means for obtaining ion intensity information on an ion originating from a predetermined component
each time the applied voltage is changed by the voltage application means, and for finding a value of voltage which gives
a maximum ion intensity based on the ion intensity information.

US Pat. No. 9,183,621

IMAGE PROCESSING APPARATUS AND RADIOGRAPHIC APPARATUS HAVING THE SAME

SHIMADZU CORPORATION, Ky...

1. An image processing apparatus for processing an image obtained by fluoroscopying a subject, the image processing apparatus
includes:
(A) a device configured to generate a band image by extracting a part of frequency components in an original image with a
figure of the subject appearing therein;

(B) a device configured to calculate magnitude and a direction of gradient of a pixel value for each pixel of the band image;
(C) an isotropic blurring device configured to generate an isotropic blur image by applying an isotropic smoothing filter
to the band image;

(D) an anisotropic blurring device configured to generate an anisotropic blur image by applying an anisotropic smoothing filter
to the band image, the anisotropic smoothing filter depending on the direction of the gradient;

(E) a device configured to calculate an index for the each pixel in accordance with the magnitude of the gradient and pixel
values surrounding the pixel in the band image; and

(F) a processed image generating device configured to superimpose the band image, the isotropic blur image, and the anisotropic
blur image for the each pixel with weighting based on the index, thereby generating a processed image with a noise component
removed from the original image.

US Pat. No. 9,082,577

ADJUSTMENT METHOD FOR ELECTRON BEAM DEVICE, AND THE ELECTRON BEAM DEVICE THUS ADJUSTED

SHIMADZU CORPORATION, Ky...

1. An adjustment method for an electron beam device comprising an electron source which generates an electron beam; three
lenses for controlling the characteristics of the electron beam, comprising a first lens, second lens and third lens arranged
in sequence starting on the upstream side in the electron beam emission direction; and a beam definition aperture arranged
on said second lens, the adjustment method comprising:
adjusting a position of the second lens such that a total lens magnification ratio obtained under maximum beam current will
substantially match an ideal lens magnification ratio specified on the basis of electro-optical characteristics.

US Pat. No. 9,060,701

MEDICAL DIAGNOSTIC IMAGING APPARATUS

SHIMADZU CORPORATION, Ky...

1. A medical diagnostic imaging apparatus comprising:
a Positron Emission Computer Tomography (PET) apparatus including a first gantry, the first gantry having a first tunnel into
which a patient is inserted; and

an x-ray Computed Tomography (CT) apparatus including a second gantry having a second tunnel into which the patient is inserted,
wherein

the first gantry is dividable into PET units along a first direction of inserting the patient into, or a second direction
of removing the patient from, the first tunnel of the first gantry, each PET unit comprising a PET detector configured to
detect a gamma ray, each PET unit being configured to be movable in the first and second directions,

the PET apparatus further comprises a guide configured to move each PET unit in the first and second directions, and
the PET apparatus has an operation mode and a maintenance mode, in the operation mode, the PET units are connected together
to allow the patient to be inserted into the first gantry for obtaining a PET image, and in the maintenance mode, at least
one PET unit is separated from others along the guide to perform maintenance of the PET apparatus.

US Pat. No. 9,648,719

HIGH-FREQUENCY POWER SUPPLY DEVICE

SHIMADZU CORPORATION, Ky...

12. A high-frequency power supply device comprising:
a DC power supply;
a series resonant circuit including an induction coil for plasma generation, and a capacitor;
a switching circuit of a half-bridge configuration or a full-bridge configuration, the switching circuit including a semiconductor
device that switches DC power supplied from the DC power supply, and provides high-frequency power to the series resonant
circuit;

a voltage detection unit configured to detect a high-frequency input voltage of the series resonant circuit;
a current detection unit configured to detect a high-frequency input current of the series resonant circuit;
a plasma input power detection unit configured to detect plasma input power based on the high-frequency input voltage and
the high-frequency input current;

an amplitude detection unit configured to detect amplitude of the high-frequency input voltage or the high-frequency input
current, or a frequency detection unit configured to detect frequency of the high-frequency input voltage or the high-frequency
input current;

an impedance detection unit configured to detect a value indicating an impedance of the induction coil based on the amplitude
detected by the amplitude detection unit or the frequency detected by the frequency detection unit; and

an impedance determination unit configured to compare a detection value of the impedance detection unit with a threshold value
that is set in advance.

US Pat. No. 9,672,330

MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer, comprising:
a mass analyzer unit that provides an MSn analysis (where n is an integer greater than two), the mass analyzer unit including an ion source and a detector, and the
mass analyzer unit performing MSm?1 analysis (where m is an integer greater than two and no greater than n) on a first component and a second component to obtain
mass analysis data for the first component and mass analysis data for the second component from the detector and performing
an MSm analysis including a dissociation operation on the first component and/or the second component;

a controller configured to control the dissociation operation; and
a data processor configured for
a) creating an MSm?1 spectrum (where m is an integer greater than two and no greater than n) based on the mass analysis data for the first component,
and creating an MSm?1 spectrum based on the mass analysis data for the second component;

b) extracting a common peak having a same mass to charge ratio in the two MSm?1 spectrums relating to the first component and the second component;

c) either excluding an ion corresponding to the common peak, or giving a low degree of priority to this ion, as a candidate
of a precursor ion for an m-1-th stage of the dissociation operation in the MSm analysis on the first component and/or the second component;

d) designating an ion corresponding to a complementary peak as the precursor ion for the m?1-th stage of the dissociation
operation in the MSm analysis on the first component and/or the second component while excluding or giving a low degree of priority to the ion
corresponding to the common peak; and

e) acquiring a subsequent MSm spectrum from the dissociation operation.

US Pat. No. 9,601,323

ION TRANSPORT APPARATUS AND MASS SPECTROMETER USING THE SAME

SHIMADZU CORPORATION, Ky...

1. An ion transport apparatus for transporting ions to a subsequent stage while trapping the ions by an effect of an electric
field, comprising:
a) an electrode group composed of a plurality of ring electrodes arranged in a substantially concentric pattern around an
aperture for sending the ions to the subsequent stage, each ring electrode having a radial sectional shape in which at least
a portion facing a side from which the ions arrive has a curved shape or a quasi-curved shape formed by a chain of line segments;
and

b) a voltage application unit for applying voltages to each of the ring electrodes included in the electrode group, in such
a manner as to apply two radio-frequency voltages whose phases are inverted from each other by 180 degrees to any two ring
electrodes neighboring each other in a radial direction among the plurality of ring electrodes, and simultaneously, to apply
a different level of direct-current voltage to each of the ring electrodes so as to form a direct-current potential gradient
which urges the ions from an outer ring electrode to an inner ring electrode of the electrode group.

US Pat. No. 9,588,088

GAS SAMPLE INTRODUCTION DEVICE

SHIMADZU CORPORATION, Ky...

1. A gas sample introduction device for introducing sample gas into a gas analysis device, comprising:
a) a metering tube having a predetermined volume;
b) a sample gas supply channel for introducing sample gas into said metering tube;
c) a carrier gas supply channel for introducing carrier gas into said metering tube;
d) an evacuation channel for discharging gas which has passed through said metering tube to the outside;
e) a concentrating means which comprises a collection tube containing an adsorbent and concentrates the sample gas through
thermal desorption;

f) a first channel changeover valve which switches between a load state in which said metering tube is interposed between
said sample gas supply channel and said evacuation channel and an injection state in which said metering tube is interposed
between said carrier gas supply channel and said gas analysis device; and

g) a second channel switching valve which, in said load state and said injection state, switches between a collection tube
interposition state and a collection tube shunt state,

wherein, in said collection tube interposition state, said collection tube is interposed between said sample gas supply channel
and said metering tube when said first channel changeover valve is in said load state, and

wherein, in said collection tube shunt state, said collection tube is disconnected from said sample gas supply channel and
said metering tube.

US Pat. No. 9,570,266

X-RAY GENERATING APPARATUS

Shimadzu Corporation, Ky...

1. An x-ray generating apparatus comprising:
a vacuum container having a main body to which an electron gun is fixed, and a moving member coupled movably and airtightly
to the main body via a vacuum bellows, the moving member being provided with a target and an x-ray irradiation window; and

a guide mechanism, provided on an outer side of the vacuum container, for regulating the movement and inclination of the moving
member in an approaching/separation direction with respect to the electron gun to maintain a distance between an electron
beam irradiation surface of the target and the electron gun constant upon movement of the moving member, wherein

the guide mechanism includes
a guide portion where a guide flat surface along a plane orthogonal to a central axis of the electron beam is formed, the
guide portion being provided on the main body side,

a guided portion where a guided flat surface facing the guide flat surface is formed, the guided portion being provided on
the moving member side, and

at least three rolling elements placed between the guide flat surface and the guided flat surface.

US Pat. No. 9,570,281

ION GENERATION DEVICE AND ION GENERATION METHOD

SHIMADZU CORPORATION, Ky...

1. An ion generation device, comprising:
a chamber, wherein the pressure is lower than the atmosphere pressure;
an electrospray ion source, located in said low pressure chamber, and used for generating ions in said chamber;
an ion guide device, located in said chamber and at the downstream of said ion source, wherein said ion guide device being
divided into at least two electrically insulated parts in the radial direction, wherein an offset voltage being applied between
said at least two parts, wherein said generated ions are guided along the direction which deviates from the spray direction
under said offset voltage; and

an ion outlet port, located at the downstream of said ion guide device, by which the ions being guided out of said chamber,
wherein the direction of ions being guided out deviates from the spray direction,

wherein the spray direction is substantially opposite to the ion outlet direction.

US Pat. No. 9,530,603

FLAT EMITTER

Shimadzu Corporation, Ky...

1. A flat emitter used for an electron source, the flat emitter comprising:
four current-supply heating legs; wherein
half lighting for a small focus in which a current is supplied to heat only a region narrower than an entire region to emit
electrons and full lighting for a large focus in which a current is supplied to heat the entire region to emit electrons are
selectable according to the combination of the legs,

all of the four current-supply heating legs are folded at a base part of an electron emission portion, and
either one of a set of the two full-lighting current-supply heating legs for the full lighting and a set of the two half-lighting
current-supply heating legs for the half lighting is linearly formed, and the other is formed to be bent plural times in zigzag
to set the space between the full-lighting current-supply heating leg and the half-lighting current-supply heating leg, which
are adjacent to each other, at their terminals to be larger than the space at their base parts.

US Pat. No. 9,506,849

MATERIAL TESTING MACHINE

SHIMADZU CORPORATION, Ky...

1. A material testing machine comprising:
a lower unit, the lower unit comprising:
a pair of first moving members each having a chuck for gripping a specimen, the first moving members being movable toward
and away from each other along a first axis by being guided by a guide member;

a pair of second moving members each having a chuck for gripping the specimen, the second moving members being movable toward
and away from each other along a second axis by being guided by a guide member;

an upper unit, separable from the lower unit, the upper unit comprising:
a load member for receiving a load applied by a loading mechanism; and
four link members for connecting the pair of first moving members and the pair of second moving members to the load member,
respectively;

the load applied to the load member being transmitted through the four link members to the pair of first moving members and
the pair of second moving members, thereby synchronously to move the pair of first moving members away from each other along
the first axis, and to move the pair of second moving members away from each other along the second axis;

wherein either the first moving members and the second moving members or the link members have seat surfaces formed thereon,
while the other have contact portions formed thereon and shaped to correspond to the seat surfaces; and

the seat surfaces and the contact portions are movable into contact with each other, respectively, thereby to connect the
pair of first moving members and the pair of second moving members to the load member through the four link members.

US Pat. No. 9,395,387

SCANNING PROBE MICROSCOPE

SHIMADZU CORPORATION, Ky...

1. A scanning probe microscope, wherein a cantilever comprising a probe is installed and is scanned along the surface of a
sample while causing the cantilever to vibrate at a frequency near the resonance point by driving with an actuator, thereby
obtaining information on the sample surface based on changes in the vibration of the cantilever due to interactions between
the sample surface and the probe, the scanning probe microscope comprising
an imaging means which images said cantilever to provide a cantilever image, and
a resonance frequency estimation means which estimates the resonance frequency of the cantilever from the cantilever image
imaged by the imaging means.

US Pat. No. 9,348,787

METHOD AND SYSTEM FOR PROCESSING ANALYSIS DATA

Shimadzu Corporation, Ky...

1. An analysis data processing method for processing signal-strength data collected for each of a plurality of samples under
two or more dimensional separation factors, comprising:
collecting the signal-strength data by using an analyzing device having: a separator section for separating a plurality of
components in a sample along a one-dimensional direction with time serving as the separation factor; and an analyzer section
for acquiring, for a sample separated into components by the separator section in the direction of time, a signal strength
in a separated form in one or more dimensional directions corresponding to one or more separation factors other than time;

performing automatically a first processing step, in which a process is performed to create a first one-dimensional table
in which, while a second variable based on the separation factor in the separator section is sequentially varied under a condition
that a first variable based on the separation factor in the analyzer section is fixed, the signal-strength data themselves
obtained for respective values of the second variable are arranged in an array direction of the numerical values of the second
variable, and this process is repeated, while changing the first variable, to create a plurality of first one-dimensional
tables for each of the plurality of samples;

performing automatically a second processing step, in which the plurality of first one-dimensional tables created for the
same sample in the first processing step are joined in the array direction of the numerical values of the second variable
to create, for each of the plurality of samples, a second one-dimensional table consisting of an array of first one-dimensional
tables, which each has a series of signal-strength values associated with a same value of the first variable; and

performing automatically a third processing step, in which the second one-dimensional tables respectively created for different
samples in the second processing step are arranged in a direction orthogonal to a dimension of the one-dimensional tables
to create a two-dimensional table.

US Pat. No. 9,305,755

MASS ANALYSIS DATA PROCESSING METHOD AND MASS ANALYSIS DATA PROCESSING APPARATUS

Shimadzu Corporation, Ky...

1. A mass analysis data processing method for processing data collected by a mass spectrometer capable of an MSn analysis where n is an integer equal to or more than two, comprising:
providing a mass spectrometer unit with samples for analysis;
running the mass spectrometer unit to collect MS1 and MSn spectrum data based on the samples provided;

executing an MS1 data-analysis step for analyzing the MS1 spectrum data collected by the mass spectrometer unit;

executing an MSn data-analysis step for performing a multivariate analysis of a matrix in which MSn analysis information based on the MSn spectrum data collected by the mass spectrometer unit is described; and

executing a display processing step for displaying, on a same window, a result of the analysis processing in the MS1 data-analysis step and a result of the multivariate analysis in the MSn data-analysis step.

US Pat. No. 9,226,703

HOLDER AND LIGHT MEASUREMENT DEVICE EMPLOYING SAME

SHIMADZU CORPORATION, Ky...

1. A holder configured to be place on a head of a subject and to hold a light-transmitting probe for emitting light to the
head and a light-receiving probe for receiving light from the head, the holder comprising:
a linear backbone portion extending in a first direction; and
at least two linear branch portions extending in a second direction different from said first direction, wherein
one of the at least two linear branch portions has at least one of probe mount portions for receiving the light-transmitting
probe and the light-receiving probe, respectively, the probe mount portions being configured to allow tips of the light-transmitting
probe and the light-receiving probe to project from the at least one of the two linear branch portions toward the side of
the head,

the probe mount portions have supports for supporting the tips, respectively, and
each support tapers off in the second direction in a plan view.

US Pat. No. 9,142,394

TANDEM QUADRUPOLE MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A tandem quadrupole mass spectrometer having front-stage and rear-stage quadrupole mass filters with a collision cell for
fragmenting an ion in between, the tandem quadrupole mass spectrometer having a function of performing a multiple reaction
monitoring (MRM) measurement condition optimization for searching for an optimum MRM measurement condition for one or a plurality
of compounds while conducting an MRM measurement of a sample, and the tandem quadrupole mass spectrometer comprising:
a) a preferred ion registry for registering a mass-to-charge ratio of one or a plurality of product ions to be preferentially
selected as a target, for each precursor ion, as a measurement condition for optimizing the MRM measurement condition; and

b) an MRM measurement condition optimizer for performing the MRM measurement condition optimization for a target precursor
ion originating from one compound by retrieving information about a preferred product ion for the precursor ion from the preferred
ion registry, and if the preferred product ion is detected as a product ion for the precursor ion, controlling each section
of the mass spectrometer so as to perform the MRM measurement condition optimization for a combination of the mass-to-charge
ratios of the precursor ion and the preferred product ion and obtain an optimum value of a control parameter.

US Pat. No. 9,083,146

SOLID STATE LASER DEVICE

SHIMADZU CORPORATION, Ky...

1. A solid state laser device, comprising:
a semiconductor laser which generates an excitation laser light;
a solid state laser medium which is excited by said excitation laser light and generates a fundamental wave;
a second harmonic generating element and third harmonic generating element, arranged inside an optical resonator formed containing
said solid state laser medium, for generating a third harmonic of the fundamental wave generated in said optical resonator;

a first temperature controller for controlling the temperature of said second harmonic generating element;
a second temperature controller for controlling the temperature of said third harmonic generating element;
a third harmonic output detector which detects the third harmonic output; and
a temperature tuning mechanism which sweeps the temperature of said third harmonic generating element to determine the optimal
temperature Ttp in a state where the temperature of said second harmonic generating element has been set to a temperature
shifted away from the vicinity of the optimal temperature, and which sweeps the temperature of said second harmonic generating
element to determine the optimal temperature Tsp in a state where the temperature of said third harmonic generating element
has been set to a temperature shifted away from the vicinity of the optimal temperature.

US Pat. No. 9,601,090

GRAPH DISPLAY PROCESSING SYSTEM

SHIMADZU CORPORATION, Ky...

1. A graph display processing system for performing a process in which each of a plurality of graphs created on a basis of
data collected by an analysis or measurement on a sample is placed in one of a plurality of windows and the windows are arranged
in a previously determined display frame on a display screen, comprising:
a) an initial position specifier for allowing an operator to independently move each of the plurality of windows in the display
frame to an arbitrary position according to an operation by the operator;

b) an initial position information acquirer for acquiring, as initial position information, information on a position of the
plurality of windows after being moved by the initial position specifier;

c) an arrangement pattern specifier for allowing the operator to perform an operation for specifying an arrangement pattern
on the display screen;

d) a post-arrangement display information calculator for calculating a display size and display position information of each
window after arrangement, based on the initial position information of each window acquired by the initial position information
acquirer and the arrangement pattern specified by the arrangement pattern specifier; and

e) an arrangement processor for resizing each window according to the display size calculated by the post-arrangement display
information calculator, and for displaying the resized windows in an arranged form according to the post-arrangement display
position information calculated by the post-arrangement display information calculator.

US Pat. No. 9,528,967

LIQUID CHROMATOGRAPH AND COLUMN OVEN FOR USE THEREIN

SHIMADZU CORPORATION, Ky...

1. A column oven for adjusting a temperature of a separation column of a liquid chromatograph, the column oven comprising:
a gas sensor configured to detect vaporized gas of a solvent contained in a mobile phase, which outputs a signal having an
intensity dependent on a value detected; and

a liquid leakage decision unit configured to receive the signal output from the gas sensor at regular time intervals to determine
whether liquid leakage of the solvent is present or not, the liquid leakage decision unit comprising,

a leak sensor value storage part configured to store a leak sensor value that is based on the intensity of the signal received
from the gas sensor,

a difference calculation part configured to, when the signal is received from the gas sensor, identify the leak sensor value
that is based on the intensity of the signal as a current leak sensor value, identify a leak sensor value that is based on
an intensity of a signal previously received from the gas sensor as a previous leak sensor value, and calculate, as a difference
value, a value obtained by subtracting the previous leak sensor value stored in the leak sensor value storage part from the
current leak sensor value, and

a liquid leakage detection part configured to detect liquid leakage in the column oven by comparing the difference value calculated
by the difference calculation part with a preset threshold,

wherein the threshold is set to a value greater than an amount of change of the leak sensor value due to a temporal change
in a sensitivity of the gas sensor.

US Pat. No. 9,518,961

LIQUID CHROMATOGRAPH AND COLUMN OVEN USED THEREFOR

SHIMADZU CORPORATION, Ky...

1. A column oven for performing temperature control on a separation column in a liquid chromatograph, comprising:
a gas sensor for detecting a vaporized gas of a solvent forming a mobile phase;
a reference-threshold-value holding part for holding, as a reference threshold value Vtho, a threshold value determined from a detected value resulting from measurement by the gas sensor, for a vaporized gas of
a certain solvent having a lower concentration than an explosive limit concentration;

a calibration-factor holding part for preliminarily holding, as a device constant, a calibration factor Ge indicating a difference
between sensitivities of the gas sensor to different solvents;

a threshold-value calibration part for calculating a threshold value Vth from the reference threshold value Vtho held in the reference-threshold-value holding part and from the calibration factor Ge held in the calibration-factor holding
part, according to

Vth=Vtho×Ge,
when a type of a solvent to be used is input; and
a liquid leakage detection part for comparing a detected value from the gas sensor with the threshold value calculated by
the threshold-value calibration part to detect a liquid leakage within the column oven, during use of the column oven.

US Pat. No. 9,498,154

MEASURING SYSTEM CAPABLE OF SEPARATING LIQUID AND DETERMINING BOUNDARY OF SEPARATED LIQUID

SHIMADZU CORPORATION, Ky...

1. A measuring system for measuring light generated from a luminescent or fluorescent substance included in a liquid to be
measured, or radiation included in the liquid to be measured, comprising:
a separating device for separating the liquid to be measured;
an imager forming an image of the separated liquid; and
a boundary calculating device for determining boundaries of the separated liquid in the image, wherein:
the measuring system measures the light or the radiation from the separated liquid within the determined boundaries, respectively;
the separating device is a flat plate having grooves of a predetermined size, the liquid being in one of the grooves in which
the liquid is separated;

an edge enhancing device is provided for enhancing shading differences in the image of the separated liquid in the flat plate,
the shading differences being treated as edges;

a flow path position extracting device is provided for extracting, based on design information on the grooves having the predetermined
size in the flat plate, and the flat plate, positions of the grooves by adjusting positions of pixels of the edges in the
image; and

the boundary calculating device determines the boundaries based on the pixels of the edges in the image comprising a detecting
device for simultaneously and two-dimensionally detecting the light or radiation included in the liquid to be measured to
obtain two-dimensional image information of the light or radiation, and a superimposition processing device for carrying out
a superimposition process to superimpose the image of the separated liquid in the separating device picked up by the image
pickup device and a distribution image of the two-dimensional image information obtained by the detecting device, wherein,
based on areas of the liquid divided by the boundary calculating device, and areas in the distribution image superimposed
thereon, information on the light or radiation in these areas is obtained; wherein the liquid to be measured is blood including
radiation, the separating device carries out plasma separation which centrifuges and separates the blood into plasma and blood
cell, and the boundary calculating device determines boundaries between plasma and blood cell, the detecting device simultaneously
and two-dimensionally detects the radiation included in the blood to obtain two-dimensional image information of the radiation,
the superimposition processing device carries out a superimposition process to superimpose the image resulting from the plasma
separation and the distribution image of the two-dimensional image information obtained by the detecting device, and based
on the plasma and blood cell divided by the boundary calculating device and the plasma and blood cell in the distribution
image superimposed thereon, a radioactive concentration is determined for each of the plasma and blood cell.

US Pat. No. 9,347,463

TURBO-MOLECULAR PUMP

Shimadzu Corporation, Ky...

1. A turbo-molecular pump comprising:
a turbo-molecular pump case;
a rotor accommodated in the turbo-molecular pump case, the rotor having rotor blades arranged in multiple steps;
a rotor shaft provided coaxially with the rotor;
a plurality of stator blades provided in the turbo-molecular pump case and arranged between the rotor blades; and
a plurality of spacers for supporting the stator blades,
wherein
one of the plurality of spacers has a cooling thick portion which covers an outer peripheral side surface of at least one
of an adjacent upper spacer and an adjacent lower spacer included among the plurality of said spacers, and

a cooling pipe through which a cooling medium is circulated is provided in the cooling thick portion.

US Pat. No. 9,341,188

BOLT-FASTENING SYSTEM FOR TURBOMOLECULAR PUMP, AND A PUMP CONTAINING THE SAME

SHIMADZU CORPORATION, Ky...

1. A bolt-fastening system for a turbomolecular pump, comprising:
a first member is fastened in a shaft direction of said turbomolecular pump with respect to a second member by a plurality
of bolts arranged concentrically with respect to a rotor shaft center,

a pair of non-penetrating pinholes of which a plurality are arranged concentrically with respect to said rotor shaft center
formed opposing one another in the respective opposing faces of said fastened first and second members,

a pin that provided for every said pair of pinholes and inserted into the respective pair of pinholes, and
wherein if a gap-size between said bolt and said bolt hole formed in said first member is Db, and a gap-size between said
pin and the pair of pinholes formed in said first member and second members is respectively Dp1, Dp2, the gap-size Db, Dp1, Dp2 satisfies an equation, D?(Dp1+Dp2).

US Pat. No. 9,322,814

MASS SPECTROMETER

SHIMADZU CORPORATION, Ky...

1. A mass spectrometer in which a sample is introduced into an ion source in such a manner that a temporal change in a concentration
of one or a plurality of sample components forms a peak, and in which a component in the sample is ionized and the generated
ions are detected with a pulse-counting detector after being separated according to their mass-to-charge ratios, the mass
spectrometer comprising:
a) a memory for storing information showing a relational expression obtained based on a result of a preliminary experiment,
the relational expression showing a relationship between the number of ions included in one chromatograph peak and a CV value
serving as an index of measurement reproducibility; and

b) a computation processor for calculating the number of ions from given measurement conditions including a loop time and
a dwell time as well as a given value of a chromatogram peak area of a target component, and for calculating a reference CV
value by comparing the calculated number of ions with the relational expression based on the information stored in the memory,
the loop time being a measurement cycle with which a measurement for sequentially detecting ions originating from one or a
plurality of specified components is repeated, the dwell time being a period of time allotted for detecting the ions originating
from the target component within the loop time, and the value of the chromatogram peak area being given as a result of an
actual or virtual measurement.

US Pat. No. 9,194,846

NEEDLE ADAPTOR AND AUTOMATIC SAMPLER USING THE SAME

SHIMADZU CORPORATION, Ky...

1. A needle adaptor mounted to a flow path switching valve to form an injection port into which a needle is inserted to inject
a sample from a tip end of the needle, comprising:
a dummy pipe having the same outer diameter as a normal pipe connected to the flow path switching valve;
a port fixing portion configured to be separated from the flow path switching valve for fixing and connecting the dummy pipe
to one of a plurality of pipe connecting ports, wherein the flow path switching valve includes the plurality of pipe connecting
ports, all of the pipe connecting ports having the same structure, and in which the needle adapter is mounted to one of the
pipe connecting ports to form the injection port;

a needle seal arranged on the end of the dummy pipe for retaining the tip end of the needle to connect the needle and the
dummy pipe; and

a needle seal housing mounted to the port fixing portion to retain the needle seal,
wherein the port adapter is configured separately from the flow path switching valve, and
wherein the port fixing portion and a port fixing, which is configured separately from the port fixing portion for the dummy
pipe, of a pipe connecting member for connecting the normal pipe to the pipe connecting port have the same shape.

US Pat. No. 9,082,602

MASS ANALYSER PROVIDING 3D ELECTROSTATIC FIELD REGION, MASS SPECTROMETER AND METHODOLOGY

SHIMADZU CORPORATION, Ky...

1. A mass analyser for use in a mass spectrometer, the mass analyser having:
a set of electrodes including electrodes arranged to form at least one electrostatic sector, the set of electrodes being spatially
arranged to be capable of providing an electrostatic field in a reference plane suitable for guiding ions along a closed orbit
in the reference plane, wherein the set of electrodes extend along a drift path that is locally orthogonal to the reference
plane, wherein the drift path curves around a reference axis included in the reference plane, so that, in use, the set of
electrodes provide a 3D electrostatic field region;

wherein the mass analyser is configured so that, in use, the 3D electrostatic field region provided by the set of electrodes
guides ions having different initial coordinates and velocities along a single predetermined 3D reference trajectory that
curves around the reference axis.

US Pat. No. 9,813,002

MOTOR CONTROLLER AND TURBO-MOLECULAR PUMP

SHIMADZU CORPORATION, Ky...

1. A motor controller comprising:
a rotation angle estimator estimating and computing a rotation angle of a motor repeatedly based on the current and voltage
of the motor without using a motor rotation angle detector;

a speed calculator calculating a period of a signal waveform of the rotation angle that is repeatedly estimated and calculated
by the rotation angle estimator and for calculating an actual rotational speed of the motor by taking the inverse of the period
of the signal waveform of the rotation angle;

a drive signal generator generating a drive signal to drive and control the motor based on at least a deviation between the
actual rotational speed and a target rotational speed and the rotation angle; and

a switching circuit that is switched based on the drive signal to provide drive power to the motor,
wherein the speed calculator comprises a binarization section binarizing the signal of the rotation angle obtained by the
rotation angle estimator, and

a calculator for calculating the period based on the binary signal obtained by the binarization section.

US Pat. No. 9,588,009

ULTRASONIC FATIGUE TESTING MACHINE AND ULTRASONIC FATIGUE TESTING METHOD

SHIMADZU CORPORATION, Ky...

1. An ultrasonic fatigue testing machine comprising:
an oscillator that outputs an electrical signal adapted to generate a high frequency wave;
an ultrasonic transducer that receives the electrical signal from the oscillator to oscillate;
a horn of which a fore end is attached with a test piece, the horn amplifying ultrasonic oscillation from the ultrasonic transducer
to transmit the amplified ultrasonic oscillation to the test piece; and

a displacement meter that is arranged in a position away, by a predetermined distance, from an end surface of a free end of
the test piece on a side opposite to an end part fixed to the horn, and measures a distance to the end surface of the test
piece, and

performing a fatigue test in an intermittent operation mode that repeats excitation applied to the test piece and a pause,
the ultrasonic fatigue testing machine including

a control part that has an internal temperature estimation part that, from a variation in the distance that is measured by
the displacement meter and from the displacement meter to the end surface of the test piece, estimates internal temperature
of the test piece, the internal temperature being due to internal heat generation of a material, the internal heat generation
being caused by the ultrasonic oscillation, and on a basis of the internal temperature of the test piece, the internal temperature
being estimated by the internal temperature estimation part, controls a start and a stop of the signal output from the oscillator.

US Pat. No. 9,535,034

ION CHROMATOGRAPH

SHIMADZU CORPORATION, Ky...

1. An ion chromatograph comprising:
a separation path including a separation column for performing separation of an ion component in a sample;
a measurement path including an electrical conductivity meter for measuring electrical conductivity; and
a suppressor including an eluate path, connecting between the separation path and the measurement path, for passing an eluate
from the separation column, a regenerant path, arranged facing the eluate path, for passing a regenerant, and an ion exchange
film, interposed between the eluate path and the regenerant path, for causing ion exchange to be performed between the paths,
the suppressor being for suppressing background electrical conductivity of the eluate from the separation column,

wherein the suppressor is structured by an ion exchange section structured by an eluate path forming member forming the eluate
path, the ion exchange film, and a regenerant path forming member forming the regenerant path being stacked with one another,
and a heat-conductive heat block covering the ion exchange section,

wherein the electrical conductivity meter and the suppressor are accommodated in a common constant temperature bath, and
wherein the ion chromatograph further comprising a suppressor temperature adjustment mechanism, having a heater to heat the
suppressor, attached to the suppressor and accommodated in the common constant temperature bath, for adjusting temperature
of the suppressor to constant temperature same as temperature in the constant temperature bath.