US Pat. No. 9,149,446

STABILIZED MUTANT OPSIN PROTEINS

UNIVERSITY OF WASHINGTON,...

1. A method of treating retinitis pigmentosa, comprising:
administering 9-cis-retinal to a human subject with retinitis pigmentosa due to expression of a mutant opsin protein with
a substitution of proline 23 by histidine, wherein the 9-cis-retinal is administered in an amount effective to bind the mutant
opsin protein to ameliorate loss of photoreceptor function.

US Pat. No. 9,320,452

MAGNETIC RESONANCE IMAGING OF AMYLOID PLAQUE IN THE BRAIN

MAYO FOUNDATION FOR MEDIC...

1. A method for acquiring an in vivo, high resolution magnetic resonance image from a subject, the steps comprising:
a) producing a trigger signal when the subject is in a preselected phase of the subject's respiratory cycle;
b) performing a pulse sequence to acquire an NMR signal when the trigger signal is produced, the pulse sequence including:
b)i) performing a preparatory pulse sequence to create uniform view-to-view longitudinal magnetization in the presence of
non-uniform view-to-view trigger times in which the longitudinal magnetization in a region of interest in the subject is set
to a preset amount by applying an rf nulling pulse with a substantially 90° flip angle followed by a preset null recovery
time (TN);

b)ii) producing transverse magnetization in the region of interest by applying an rf excitation pulse after step b)i);
b)iii) producing an NMR echo signal at a preselected time (TE) after application of the rf excitation pulse;
b)iv) acquiring the NMR echo signal in the presence of a readout magnetic field gradient;
c) changing a magnetic field gradient in the pulse sequence and repeating step b) to acquire another NMR signal; and
d) repeating step c) until sufficient NMR echo signals are acquired to reconstruct an image.

US Pat. No. 9,352,155

CHAOTIC DESYNCHRONIZATION OF NEURAL POPULATIONS WITH NON-PULSATILE INPUTS

The Regents of the Univer...

1. A method of brain stimulation for treatment of a neurological disease, comprising:
(a) stimulating neurons in a brain region;
(b) measuring or calculating a phase response curve for a population of interest of said stimulated neurons; and
(c) calculating by a computer programmed device and using said measured or calculated phase response curve, stimulus parameters
and waveforms to synchronize or desynchronize neuronal oscillators in said brain region, wherein said calculation is based
on a Lyapunov exponent described in terms of said measured or calculated phase response curve.

US Pat. No. 9,435,804

DETECTION, PREVENTION, AND TREATMENT OF ANTHRAX AND OTHER INFECTIOUS DISEASES

Board of Regents of the N...

1. A method of diagnosing infection by a PGA producing pathogen in a subject from a vertebrate species, comprising:
assaying soluble PGA in a biological sample obtained from the subject using an anti-PGA antibody, the assay generating a detectable
signal if the level of soluble PGA in the sample exceeds a predetermined amount, the predetermined amount is 140 pg/ml.

US Pat. No. 9,211,688

NON-WOVEN FIBERS-IN-FIBERS FROM MELT-BLOWN POLYMER BLENDS

CUMMINS FILTRATION IP, IN...

1. A method comprising melt-blowing a blend of a first polymer and an immiscible second polymer to form a composite polymeric
fiber having an island-in-sea morphology, wherein the first polymer forms a matrix that surrounds the second polymer and the
second polymer forms nanofibers within the matrix, the nanofibers having an average diameter of less than about 500 nm, and
wherein the second polymer comprises poly(ethylene-co-chlorotrifluoroethylene (PECTFE).
US Pat. No. 9,127,050

MULTICOMPONENT IMMUNOGENIC COMPOSITION FOR THE PREVENTION OF BETA-HEMOLYTIC STREPTOCOCCAL (BHS) DISEASE

Regents of the University...

1. An immunogenic composition comprising an effective amount of a first polypeptide encoded by a nucleic acid set forth as
SEQ ID NO:1 and an effective amount of a second polypeptide encoded by a nucleic acid set forth as SEQ ID NO:7.

US Pat. No. 9,363,679

ROBUST PARAMETRIC POWER SPECTRAL DENSITY (PSD) CONSTRUCTION

Regents of the University...

1. A method comprising:
sensing local radio-frequency (RF) interference spectrum at each of a plurality of sensors positioned at a plurality of locations
within a geographic region;

computing a basis expansion model from the sensed RF interference spectrum, wherein the basis expansion model comprises a
set of reference basis functions that represent a distribution of RF power emitted by RF-enabled devices throughout the geographic
region as a function of frequency and location;

computing coefficients for the reference basis functions of the basis expansion model using a group sparse least-absolute-shrinkage-and-selection
operator (GS-Lasso); and

constructing, in accordance with the basis expansion model, a power spectral density (PSD) map representative of the distribution
of RF power throughout the geographic region.

US Pat. No. 9,228,172

INDUCIBLE REGULATORY T-CELL GENERATION FOR HEMATOPOIETIC TRANSPLANTS

The Trustees of the Unive...

1. A method of generating and expanding an inducible T regulatory cell (iTreg), said method comprising
isolating a non-Treg from peripheral blood, wherein said non-Treg is selected from the group consisting of a CD4+cell, a CD4+CD25?cell, and a CD4+CD25?CD45RA+cell;

contacting the non-Treg with a combination of agents capable of converting said non-Treg into an iTreg, wherein the combination
of agents comprise a tryptophan catabolite, and a demethylating agent selected from the group consisting of 5-aza-2?-deoxycitidine,
5-Azacytidine, and any combination thereof;

contacting the iTreg with a mTOR inhibitor separate from the combination of agents, wherein the mTOR inhibitor inhibits non-Treg
growth and is selected from the group consisting of tacrolimus, rapamycin , rapamycin derivative, and any combination thereof;
and

expanding the iTreg under appropriate growth conditions.
US Pat. No. 9,862,928

GENERATION OF NATURAL KILLER CELLS AND LYMPHOID TISSUE INDUCER-LIKE (LTI-LIKE) NK-22 CELLS

Regents of the University...

1. A method to produce IL-22 expressing Lymphoid Tissue Inducer-Like (LTi-like) NK22 cells comprising
a) initially culturing CD34+ cells in the presence of IL-3 and irradiated stroma;

b) culturing the cells from a) in the presence of stem cell factor (SCF), FLT-3L, IL-7, IL-15 and irradiated stroma;
c) culturing the cells from b) in the presence of IL-1? and IL-23, but in the absence of IL-7, so as to produce IL-22 expressing
LTi-like NK22 cells.

US Pat. No. 9,522,081

METHODS AND DEVICES FOR BRAIN COOLING FOR TREATMENT AND/OR PREVENTION OF EPILEPTIC SEIZURES

University of Washington,...

1. An implantable passive cooling device configured to be inserted into an aperture in a skull for focally cooling a brain,
the device comprising:
a passive thermally conductive prosthesis sized and configured to be inserted into an aperture formed in a skull, the prosthesis
having an inner surface configured to contact a portion of a meninges or brain disposed in the skull, and an outer surface
configured to contact a corresponding portion of a scalp covering the skull;

wherein the passive thermally conductive prosthesis replaces a thermally insulating bone section to passively produce a focal
cooling in the contacted portion of the meninges or brain.

US Pat. No. 9,207,207

DRIFT TUBE ION MOBILITY SPECTROMETER FOR AEROSOL MEASUREMENT

Regents of the University...

1. A method comprising:
introducing a sample aerosol into a drift tube of an ion mobility spectrometer;
introducing a carrier gas into the drift tube of the ion mobility spectrometer such that at least a portion of the carrier
gas flows through the drift tube in a direction generally opposing migration of ionized particles through the drift tube,

wherein the sample aerosol and carrier gas are introduced into the drift tube such that the sample aerosol circulates within
a portion of the drift tube, and

wherein an applied electrostatic separation field blocks migration of ionized particles in the sample aerosol into a separation
region of the drift tube; and

applying a capturing electric field to the drift tube to increase the electrical potential of ionized particles within at
least a portion of the sample circulation to a potential greater than that of the applied electrostatic separation field to
allow the ionized particles at the increased potential to migrate in the drift tube down a gradient of the applied separation
field against the flow of the carrier gas to separate according to their ion mobility.

US Pat. No. 9,150,600

TRIPTOLIDE PRODRUGS

Regents of the University...

1. A method for treating cancer in a mammal, comprising administering to the mammal a compound of formula I:
wherein:
each R1 is independently H, (C1-C6)alkyl, aryl(C1-C6)alkyl-, (C3-C6)cycloalkyl or aryl; and each R2 is independently H, (C1-C6)alkyl, aryl(C1-C6)alkyl-, (C3-C6)cycloalkyl or aryl; or R1 and R2 together with the atom to which they are attached form a (C3-C7)cycloalkyl; wherein any alkyl or cycloalkyl of R1 or R2 may be optionally substituted with one or more groups selected from halo, (C1-C6)alkoxy and NRaRb and wherein any aryl of R1 or R2 may be optionally substituted with one or more groups selected from halo, (C1-C6)alkyl, (C1-C6)alkoxy, NRaRb, nitro and cyano;

Ra and Rb are each independently selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl and aryl; or Ra and Rb together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, azetidino, morpholino, or
thiomorpholino;

n is 1, 2 or 3; and
each X is H;
or a pharmaceutically acceptable salt thereof;
wherein the cancer is selected from pancreatic cancer, bile duct carcinoma, neuroblastoma, colon cancer, breast cancer, myeloma,
gastric cancer, liver cancer, glioblastoma, ovarian cancer, colorectal cancer, non-Hodgkin lymphoma, lung cancer, prostate
cancer, small-cell lung cancer, large cell lung cancer, kidney cancer, esophageal cancer, stomach cancer, cervical cancer
and lymphoma tumors.

US Pat. No. 10,035,719

SYSTEM AND MEMBRANE FOR WASTEWATER-GENERATED ENERGY AND GAS

Regents of the University...

1. An apparatus for producing a gas from a wastewater fluid, the apparatus comprising:a first layer including a first immobilized bacteria, wherein the first immobilized bacteria are configured to produce a first gas from one or more compounds in a wastewater fluid;
a second layer including a second immobilized bacteria, wherein the second immobilized bacteria are configured to produce a second gas from the one or more compounds in the wastewater fluid; and
a third layer at least partially disposed between the first layer and the second layer, the third layer configured to receive at least one of the first gas and the second gas from the first layer and the second layer, respectively.

US Pat. No. 9,230,539

AUTOMATIC MEASUREMENT OF SPEECH FLUENCY

Regents of the University...

1. A system comprising:
a computer-readable medium having stored thereon model data that includes at least one model of a characteristic of a language
spoken by a patient; and

a speech analyzer configured to analyze an audio sample including speech of the patient, identify phonemes from the speech
of the patient, analyze the identified phonemes to identify prosodic characteristics of the speech of the patient using the
model, and automatically measure fluency of the speech of the patient based on the prosodic characteristics.

US Pat. No. 9,216,044

STRIPPED PEDICLE SCREW DRIVER BIT

Regents of the University...

1. A pedicle screw driver bit comprising:
an elongated shank comprising a plurality of threads; and
a head connected to one end of the shank,
wherein the head is configured to be received by opposing rod-receiving slots of a tulip connected to a pedicle screw,
wherein the tulip comprises a cylindrical collar that includes a first end and a second end to which an end of the pedicle
screw is connected, and

wherein the threads of the shank are configured to engage a plurality of threads formed on at least one interior surface of
the tulip such that when the shank is rotated the tulip is drawn into engagement with the head such that the head is seated
in the opposing rod-receiving slots of the tulip, and the shank, the head, the tulip, and the pedicle screw are substantially
prevented from rotating relative to one another such that they rotate together as a unit to facilitate rotating the pedicle
screw with the pedicle screw driver bit.

US Pat. No. 9,073,038

CARBON COATED SILICA PARTICLES AND METHODS OF MAKING SAME

Regents of the University...

1. A method of preparing silica particles having a metal adsorbed thereon, the method comprising:
dispersing silica particles in an aqueous liquid having a pH of less than or equal to 7;
adding a soluble source for one or more metal cations to the aqueous liquid having the silica particles dispersed therein;
and

increasing the pH of the aqueous liquid with the metal cations and the silica particles dispersed therein sufficiently slowly
to provide homogeneous precipitation of the metal on a surface of the silica particles and form the silica particles having
the metal adsorbed thereon.

US Pat. No. 9,670,247

CONTRACEPTIVE AGENTS

The University of Kansas,...

1. A compound of formula:
wherein:
R1 is H, (C1-C6)alkyl, or Rc, wherein the (C1-C6)alkyl is optionally substituted with one or more halo or (C1-C6)alkoxy;

R2 is H or (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with one or more halo or (C1-C6)alkoxy;

R3 is H or (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with one or more halo or (C1-C6)alkoxy;

R4 is Ra, cyano, formyl, carboxy, hydroximinomethyl, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, aryl, heteroaryl, or (C1-C4)alkanoyl, wherein the (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, and (C1-C4)alkanoyl is optionally substituted with one or more groups selected from hydroxy, halo, aryl, and heteroaryl; wherein any
aryl and heteroaryl of R4 is optionally substituted with one or more Rb;

R5 is H or (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with one or more halo or (C1-C6)alkoxy;

R6 is H or (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with one or more halo or (C1-C6)alkoxy; and

R7 is H or (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with one or more halo or (C1-C6)alkoxy; or R6 and R7 taken together form a (C1-C6)alkylene;

Ra, is a 4, 5, or 6 membered saturated or partially unsaturated heterocyclic ring comprising at least one carbon atom and at
least one heteroatom selected from S, or NH in the ring, which ring is optionally substituted with one or more oxo (?O);

Rb, is aryl or aryl(C1-C6)alkyl, wherein the aryl or aryl(C1-C6)alkyl is optionally substituted with one or more (C1-C6)alkoxy or halo;

Rc, is a C-linked amino acid, a C-linked dipeptide, —C(?O)CH2CH2COOH, —P(?O)(OH)2, or:


Rd is H, (C1-C6)alkanoyl, or (C1-C6)alkyl, wherein the (C1-C6)alkanoyl and the (C1-C6)alkyl are each optionally substituted with one or more halo or (C1-C6)alkoxy; and Re is H, (C1-C6)alkanoyl, or (C1-C6)alkyl, wherein the (C1-C6)alkanoyl and the (C1-C6)alkyl are each optionally substituted with one or more halo or (C1-C6)alkoxy; or Rd and Re taken together form a (C1-C6)alkylene; and

Rf is H, (C1-C6)alkanoyl, or (C1-C6)alkyl, wherein the (C1-C6)alkanoyl and the (C1-C6)alkyl are each optionally substituted with one or more halo or (C1-C6)alkoxy;

or a salt thereof,
when Rc, is

then R4 is
with R being 4-fluorobenzyl or benzyl,
when R4 is carboxy, then R1 is methoxymethyl, R2 is H, R3 is methoxymethyl, R5 is methoxymethyl, and R6 and R7 taken together form —C(CH3)2?.

US Pat. No. 9,375,484

TAXANE SILICATE PRODRUGS AND NANOPARTICLES

REGENTS OF THE UNIVERSITY...

3. A compound of formula (Ia):

wherein R1 is a group of formula (I),

—Si(OR)3  (I)

wherein:
each R is independently selected from (C1-C20)alkyl, (C2-C20)alkenyl, (C2-C20)alkynyl, (C1-C20)alkanoyl, (C2-C20)alkenylcarbonyl, and (C2-C20)alkynylcarbonyl, wherein each (C1-C20)alkyl, (C2-C20)alkenyl, (C2-C20)alkynyl, (C1-C20)alkanoyl, (C2-C20)alkenylcarbonyl, and (C2-C20)alkynylcarbonyl, is optionally substituted with one or more hydroxy, (C1-C6)alkoxy, oxo, halo, or aryl;

or a salt thereof.
US Pat. No. 9,193,873

METHOD OF FACILITATING REMOVAL OF BIOORGANIC STAINS FROM SURFACES

Toyota Motor Corporation,...

1. A protein-polymer composite material, comprising:
one or more amylases dispersed in a two component non-aqueous organic solvent-borne polymer resin, said amylase in the form
of a particle with an average particle size, wherein said average particle size in the protein-polymer composite material
is in the range of 10 ?m (average diameter) or less.

US Pat. No. 9,097,769

SIMULTANEOUS TX-RX FOR MRI SYSTEMS AND OTHER ANTENNA DEVICES

Life Services, LLC, Minn...

1. A method comprising:
providing a magnetic-resonance (MR) coil having a plurality of antenna elements;
locating the MR coil in a bore of an MR magnet;
transmitting an MR transmit signal (TX signal) using the MR coil;
receiving an MR receive signal (RX signal) using the MR coil simultaneously with the transmitting of the MR transmit signal
(TX signal);

removing artifacts of the TX signal from the received MR receive signal (RX signal) to form a net received signal (NRX signal),wherein the removing artifacts of the transmit signal from the received MR receive signal further includes:
splitting an RF pulse into a first portion and a second portion, wherein the first portion is amplified and transmitted as
the MR transmit signal (TX), and

subtracting the second portion from the received MR receive signal (RX) to form the NRX signal; and
processing the net received signal (NRX signal) and generating MR output data from the processed NRX signal.

US Pat. No. 9,441,483

ADJUSTABLE LINKAGE FOR VARIABLE DISPLACEMENT

Regents of the University...

1. An apparatus comprising:
a crank-slider linkage, wherein the crank is coupled to the slider by a jointed connecting rod, the jointed connecting rod
having a first link and a second link, the first link coupled to the second link by a first revolute joint, the first link
coupled to the crank and having a longitudinal axis;

a rocker link having a rocker end and a ground end, the rocker end coupled to the jointed connecting rod and the ground end
coupled to ground by a second revolute joint, the rocker link and the second link disposed on a common side of the longitudinal
axis;

wherein the slider is configured for linear movement along a center axis, one end of the linear movement includes a first
position; and

wherein the second revolute joint is adjustable along an arc and wherein the location of the first position remains fixed
with a change in the position of the second revolute joint along the arc.

US Pat. No. 9,428,740

LIPASE-CONTAINING POLYMERIC COATINGS FOR THE FACILITATED REMOVAL OF FINGERPRINTS

Toyota Motor Corporation,...

1. A composition for facilitating fingerprint removal comprising:
a polymeric coating material formed from crosslinkable non-aqueous organic solvent-borne resin; and
a lipase capable of degrading a fingerprint component, said lipase associated with said coating material so as to be capable
of facilitating fingerprint removal when said coating material is contacted by a fingerprint;

with the proviso that when the lipase is a triacylglycerol lipase, the triacylglycerol lipase is from Acinetobacter, Aedes aegypti, Anguilla japonica, Antrodia cinnamomea, Arabidopsis rosette, Arabidopsis thaliana, Arxula adeninivorans,
Aspergillus oryzae, Aspergillus tamarii, Aureobasidium pullulans, Avena sativa, Bacillus licheniformis, Bacillus sphaericus,
Bacillus stearothermophilus, Bacillus subtilis, Bacillus thermocatenulatus, Bacillus thermoleovorans, Bombyx mandarina, Bombyx
mori, Bos Taurus, Brassica napus, Brassica rapa, Burkholderia cepacia, Caenorhabditis elegans, Candida albicans, Candida antarctica,
Candida deformans, Candida parapsilosis, Candida rugosa, Candida thermophila, Canis domesticus, Chenopodium rubrum, Clostridium
beijerinckii, Clostridium botulinum, Clostridium novyi, Danio rerio, Galactomyces geotrichum, Gallus gallus, Geobacillus,
Gibberella zeae, Gossypium hirsutum, Homo sapiens, Kurtzmanomyces sp., Leishmania infantum, Lycopersicon esculentum L, Malassezia furfur, Methanosarcina acetivorans, Mus musculus, Mus spretus, Mycobacterium tuberculosis, Mycoplasma hyopneumoniae,
Myxococcus xanthus, Neosartorya fischeri, Oryctolagus cuniculus, Oryza sativa, Penicillium cye/opium, Phlebotomus papatasi,
Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas fragi, Pseudomonas sp, Rattus norvegicus, Rhizomucor miehei, Rhizopus oryzae, Rhizopus stolonifer, Ricinus communis, Samia Cynthia ricini, Schizosaccharomyces
pombe, Serratia marcescens, Spermophilus tridecemlineatus, Staphylococcus simulans, Staphylococcus xylosus, Sulfolobus solfataricus,
Sus scrofa, Thermomyces lanuginosus, Trichomonas vaginalis, Vibrio harveyi, Xenopus laevis, or Yarrowia lipolytica;
said composition uniformly coated onto a substrate.

US Pat. No. 9,341,691

SHORT TE 3D RADIAL SAMPLING SEQUENCE FOR MRI

Regents of the University...

4. A method of operating a magnetic resonance scanner, the method comprising:
providing a radio frequency excitation pulse to a specimen, the radio frequency excitation pulse having a duration;
concurrent with providing the radio frequency excitation pulse, applying a first gradient having a first polarity, wherein
applying the first gradient includes selecting a spoke in k-space data, the k-space data corresponding to a radial image;

applying a readout gradient at a time after the duration, the readout gradient having inverse polarity relative to the first
polarity;

acquiring magnetic resonance data from the specimen while applying the readout gradient; and
generating an image based on the magnetic resonance data.

US Pat. No. 9,285,218

SHORTEST TRAVEL PATH DETERMINATION USING CRITICAL START TIME POINTS

Regents of the University...

1. A method comprising:
obtaining a set of start times;
determining a shortest path from a source to a destination for a current start time in the set of start times;
a processor identifying a critical start time in the set of start times temporally separated from the current start time by
at least one intermediate start time in the set of start times wherein identifying a critical start time comprises:

identifying a shortest path from the source to a current node;
identifying at least two edges that extend from the current node;
for each edge that extends from the current node, determining path functions that indicate an earliest arrival time for traveling
from the source to an end of the edge opposite the current node for each start time in the set of start times after the current
start time;

comparing each of the path functions for each edge at each start time after the current start time; and
identifying each start time at which the edge with the earliest path function changes as a critical start time;
setting the shortest path from the source to the destination for the current start time as the shortest path for the at least
one intermediate start time without separately determining the shortest path for the at least one intermediate start time;

determining a different shortest path from the source to the destination for the critical start time than for the current
start time; and

generating a user interface displaying a plurality of shortest paths from the source to the destination.

US Pat. No. 9,222,845

FLEXIBLE SENSORS AND RELATED SYSTEMS FOR DETERMINING FORCES APPLIED TO AN OBJECT, SUCH AS A SURGICAL INSTRUMENT, AND METHODS FOR MANUFACTURING SAME

Regents of the University...

1. A method of manufacturing a flexible force sensor, the method comprising:
forming a first sensor part defining a central longitudinal axis and including a plurality of first electrode plates in a
first non-conductive material, an inner rim, and an outer rim, the first electrode plates being circumferentially spaced from
one another and located radially between the inner and outer rims relative to the longitudinal axis, wherein the inner and
outer rims project axially beyond the first electrode plates in a direction of the longitudinal axis;

forming a second sensor part including a plurality of second electrode plates in a second non-conductive material, the second
electrode plates being identical to the first electrode plates in at least shape and circumferential spacing; and

assembling the first sensor part to the second sensor part such that respective ones of the first electrode plates are aligned
with and spaced from respective ones of the second electrode plates to establish a plurality of capacitive sensing components;

wherein the step of assembling includes the first sensor part in direct, abutting contact with the second sensor part at the
inner and outer rims, including the first sensor part in direct, abutting contact with the second sensor part at a circumferential
region of direct interface having a minimum radius that is greater than a maximum radius of the first electrode plates relative
to the longitudinal axis;

wherein the respective first electrode plate of each of the capacitive sensing components is movable relative to the corresponding
respective second electrode plate to establish a variable gap therebetween;

wherein the first and second sensor parts are ring-shaped, such that upon final assembly, the flexible force sensor defines
a central bore.

US Pat. No. 9,133,319

CLAY-ISOCYANATE NANODISPERSIONS AND POLYURETHANE NANOCOMPOSITE PRODUCED THEREWITH

Huntsman International LL...

1. A method comprising:
adding a pre-exfoliated inorganic clay to an isocyanate, said pre-exfoliated inorganic clay is free from modification by an
organic counter ion and has not been introduced to an aqueous acidic medium;

causing the inorganic clay to delaminate to form a clay nanodispersion;
mixing said clay nanodispersion with an isocyante-reactive component and a blowing agent to form a reactive mixture; and
allowing the reactive mixture to foam thereby forming a rigid polyurethane foam having a closed cell content greater than
80%.

US Pat. No. 9,447,380

NON-STATIC SUSPENSION CULTURE OF CELL AGGREGATES

Regents of The University...

1. A method for making a cell culture composition comprising aggregates of stem cells that are not embryonic stem cells, embryonic
germ cells, or germ cells, wherein the aggregates are in non-static cell culture and wherein the cell density ranges from
about 5×104 cells/ml to about 108 cells/ml, the method comprising inoculating a cell culture with stem cell aggregates and expanding the inoculated aggregates
so that expansion produces a cell density of about 5×104 cells/ml to about 108 cells/ml.

US Pat. No. 9,374,143

ESTIMATING FREQUENCY-OFFSETS AND MULTI-ANTENNA CHANNELS IN MIMO OFDM SYSTEMS

Regents of the University...

1. A method comprising:
forming, with a wireless communication device, blocks of symbols by inserting training symbols within two or more blocks of
information-bearing symbols;

applying, with the wireless communication device, a hopping code to each of the blocks of symbols to insert a null subcarrier
within each of the blocks of symbols, wherein the hopping code causes a position of the null subcarrier to change from block
to block, wherein the position change caused by the hopping code is based, at least, on a block length and a cyclic prefix
length, wherein the cyclic prefix length is based, at least, on a characteristic of a wireless communication channel; and

outputting, via Nt antennas of the wireless communication device, a wireless transmission signal in accordance with the blocks of symbols, the
wireless transmission signal being configured to be received via Nr antennas, wherein each of Nt and Nr is an integer, and wherein at least one of Nt and Nr is an integer greater than one.

US Pat. No. 9,266,931

MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES

Regents of the University...

1. An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a vitamin K-dependent polypeptide that comprises
a modified gamma-carboxyglutamic acid (GLA) domain that enhances membrane binding affinity of said vitamin K-dependent polypeptide
relative to a corresponding native vitamin K-dependent polypeptide, wherein said modified GLA domain comprises the sequence
of SEQ ID NO:3 or SEQ ID NO:4 with one to five amino acid substitutions, wherein the proline residue at position 10 of SEQ
ID NO:3 or SEQ ID NO:4 is substituted with a glutamine, aspartic acid, or glutamic acid residue in the modified GLA domain.

US Pat. No. 9,050,611

HIGH MASS THROUGHPUT PARTICLE GENERATION USING MULTIPLE NOZZLE SPRAYING

REGENTS OF THE UNIVERSITY...

1. An apparatus for electrospraying particles, the apparatus comprising:
a particle source;
a dispensing device configured to receive source material from the particle source, wherein the dispensing device comprises
a slit defined by at least two opposing surfaces terminating at a dispensing end of the dispensing device, wherein the dispensing
device defines a plurality of nozzle structures spaced along the slit at the dispensing end of the dispensing device, wherein
each nozzle structure comprises at least one nozzle projection extending a distance beyond portions of the at least two opposing
surfaces terminating along the slit defined at the dispensing end of the dispensing device to provide a cone jet to spray
microdroplets; and

an electrode isolated from the dispensing end, wherein a nonuniform electrical field is created between the dispensing end
and the electrode such that a spray of microdroplets having an electrical charge applied thereto is dispensed from the dispensing
end of dispensing device.

US Pat. No. 9,051,421

NANOPOROUS LINEAR POLYETHYLENE MEMBRANES AND BLOCK COPOLYMER PRECURSORS FOR SAME

Regents of the University...

1. A process for preparing a polymer composite comprising:
(a) reacting a hydroxyl-terminated, linear polyolefin polymer with a cyclic ester in the presence of a ring opening catalyst
to form a block copolymer that includes at least one polyester block and at least one linear polyolefin block, the block copolymer
being in the form of a nano-structured, bicontinuous composite comprising a continuous matrix phase and a second continuous
phase, wherein the continuous matrix phase comprises the linear polyolefin block of the block copolymer, and the second continuous
phase comprises the polyester block of the block copolymer; and

(b) treating the bicontinuous composite to selectively remove the polyester block of the block copolymer to form a plurality
of pores.

US Pat. No. 9,364,406

OPEN CHAINED OR FUSED 1,1?-ALKYLENE-BIS-URACIL DERIVATIVES, USEFUL IN SKIN UV-PROTECTION

REGENTS OF THE UNIVERSITY...

1. A compound of formula I:

wherein:
each R1 is independently H, (C1-C6)alkyl, (C3-C7)carbocycle or RaC(?O); or the two R1 groups together form a —(C3-C8)alkyl- group, a —(C2-C6)alkyl-Y—(C2-C6)alkyl- group or a —(C1-C6)alkyl-Y?—(C1-C6)alkyl- group;

the dashed bonds labeled “a” are absent and the dashed bonds labeled “b” are double bonds; or all the dashed bonds are single
bonds;

R2 is H, (C1-C6)alkyl or aryl, wherein aryl is optionally substituted with one or more Z1 groups;

R3 is H, (C1-C6)alkyl or aryl, wherein aryl is optionally substituted with one or more Z1 groups;

R4 is carboxy, (C1-C6)alkoxycarbonyl, —OPO3H2, —ORc, or —NRdRe; and R5 is H;

Y is O, S, NH, P, P(?O) or POH;
Y? is Si(Rb)2 or —Si(Rb)2—O—Si(Rb)2—;

each Ra is independently (C1-C6)alkyl, (C3-C7)carbocycle or aryl, wherein aryl is optionally substituted with one or more Z1 groups;

each Rb is independently (C1-C6)alkyl, (C3-C7)carbocycle or aryl, wherein aryl is optionally substituted with one or more Z1 groups;

Rc is Rf or a C1-C20 saturated or C2-C20 unsaturated carbon chain that is optionally substituted with one or more groups independently selected from oxo (?O), hydroxy,
mercapto, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkanoyloxy, NRdRe, carboxy, and aryl, wherein aryl is optionally substituted with one or more Z1 groups;

Rd is H, (C1-C6)alkyl, or (C1-C6)alkanoyl;

Re is H or a C1-C20 saturated or C2-C20 unsaturated carbon chain that is optionally substituted with one or more groups independently selected from oxo (?O), hydroxy,
mercapto, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkanoyloxy, NRdRe, carboxy, and aryl, wherein aryl is optionally substituted with one or more Z1 groups;

each Rf is:


each Z1 is independently selected from (C1-C6)alkyl, halogen, —CN, —ORn1, —NRq1Rr1, —NRn1CORp1, —NRn1CO2Rp1, NO2, —C(O)Rn1, —C(O)ORn1 and —C(O)NRq1Rr1, wherein any (C1-C6)alkyl of Z1 is optionally substituted with one or more halogen;

each Rn1 is independently selected from H and (C1-C6)alkyl, wherein any (C1-C6)alkyl of Rn1 is optionally substituted with one or more halogen;

each Rp1 is independently (C1-C6)alkyl; and

Rq1 and Rr1 are each independently selected from H and (C1-C6)alkyl or Rq1 and Rr1 together with the nitrogen to which they are attached form a piperidine, pyrrolidine, morpholine, azetidine, thiomorpholine,
piperazine or 4-methylpiperazine;

or a salt thereof.
US Pat. No. 9,249,225

SINGLE CHAIN VARIABLE FRAGMENT ANTI-CD133 ANTIBODIES AND USES THEREOF

Regents of the University...

1. The hybridoma identified herein as Hybridoma Clone 7.

US Pat. No. 9,222,856

MEASUREMENT OF PARTICLE MORPHOLOGY USING FILTRATION

Regents of the University...

1. A system for characterizing a totality of particles, comprising:
a classification apparatus to select a class of the totality of particles having a defined mobility;
a first particle counter apparatus positioned in a first path of the system for use in determining total particle concentration
of the selected class of particles;

a filter apparatus positioned in a second path of the system, wherein the filter apparatus is defined such that particles
of the selected class with different morphologies correspond to different penetration levels therethrough;

a second particle counter apparatus positioned in the second path for use in determining a filtered particle concentration
indicative of particles of the selected class which penetrate the filter apparatus; and

a calibrator apparatus configured to determine at least one morphological parameter based on the fraction of particles of
the selected class penetrating the filter apparatus, the fraction determined as a function of the total particle concentration
and the filtered particle concentration, wherein the at least one morphological parameter comprises at least information about
the particles of the selected class penetrating the filter apparatus.

US Pat. No. 9,155,798

RECEPTOR-TARGETING REAGENTS CONTAINING EPIDERMAL FACTOR RECEPTOR-BINDING AGENTS AND IL-13 RECEPTOR-BINDING AGENTS OR IL-4 RECEPTOR-BINDING AGENTS

Regents of the University...

2. A linear fusion protein immunotoxic receptor-targeting reagent comprising SEQ ID NO: 1, SEQ ID NO:3, SEQ ID NO:18, or SEQ
ID NO:19.
US Pat. No. 9,085,757

PRODUCTION OF INSULIN PRODUCING CELLS

Regents of the University...

1. An in vitro method to differentiate stem cells to pancreatic progenitor cells comprising the steps of:
a) contacting the stem cells with at least one member of the TGF? family of cytokines and at least one member of the Wnt family
of proteins,

b) contacting the cells obtained from step a) with at least one member of the TGF? family of cytokines, at least one member
of the Wnt family of proteins, and an agent that inhibits sonic hedgehog activity; and

c) contacting the cells obtained from step b) with a member of the Epidermal growth factor (EGF) family of proteins;
so as to yield pancreatic progenitor cells.

US Pat. No. 9,194,802

LUMINESCENT PROBES HAVING A PHENANTHRIDINYL ANTENNA, AND METHODS OF USE

Regents of the University...

1. A luminescent probe comprising a structure of the formula:
wherein:
each R1 represents hydrogen, a C1-C10 hydrocarbon moiety, a halogen, or Z;

R2 represents hydrogen or a C1-C10 hydrocarbon moiety group;

R3 represents hydrogen, a C1-C10 hydrocarbon moiety, or a halogen;

wherein for molecules in which one or more of R1, R2, and/or R3 represents a C1-C10 hydrocarbon moiety, two or more of R1, R2, and R3 may optionally be joined with one another to form one or more fused rings;

n=0 or 1; and
Z represents a chelated luminescent Lanthanide (Ln) complex attached to the phenanthridine with a —C(R5)2NHC(O)CH2-Lanthanide (Ln) complex linkage, wherein each R5 independently represents hydrogen with the proviso that one R1=Z.

US Pat. No. 9,364,505

THERAPEUTIC COMPOSITION FOR TREATMENT OF GLIOBLASTOMA

REGENTS OF THE UNIVERSITY...

1. An anti-tumor composition comprising an adherent glioblastoma GBM6-AD stem cell, wherein the adherent glioblastoma GBM6-AD
stem cell is ATCC® Patent Deposit Designation PTA-11498.

US Pat. No. 9,243,916

OBSERVABILITY-CONSTRAINED VISION-AIDED INERTIAL NAVIGATION

Regents of the University...

1. A vision-aided inertial navigation system comprising:
at least one image source to produce image data for an environment;
an inertial measurement unit (IMU) to produce IMU data indicative of motion of the vision-aided inertial navigation system;
and

a hardware-based processor configured to execute an estimator that computes state estimates for the vision-aided inertial
navigation system based on the image data and the IMU data,

wherein the estimator applies a constrained estimation algorithm that computes the state estimates based on the IMU data and
the image data while preventing projection of information from the image data and IMU data along at least one unobservable
degrees of freedom for the vision-aided inertial navigation system.

US Pat. No. 9,149,450

ISCHEMIA/REPERFUSION PROTECTION COMPOSITIONS AND METHODS OF USING

Regents of the University...

1. A method for treating an individual who is experiencing or has experienced blood loss, comprising administering a composition
to the individual, wherein the composition comprises about 2 M to about 6 M D-beta-hydroxybutyrate or a pharmaceutically acceptable
salt thereof, about 25 mM to about 80 mM melatonin or a metabolite, precursor or analog thereof, and at least one solvent.

US Pat. No. 9,101,520

MOBILE MANUAL STANDING WHEELCHAIR

The United States of Amer...

1. A manually propelled standing wheelchair comprising:
a chassis having a front portion, a rear portion, a center portion, a left portion, a right portion, a top portion, and a
bottom portion;

at least two ground drive wheels, one of said two ground drive wheels being disposed on said left portion of said chassis,
and one of said two ground drive wheels being disposed on said right portion of said chassis;

a rotating structure, comprising a left rotating structure and a right rotating structure, wherein each of said left rotating
structure and said right rotating structure is attached, respectively, to said left portion and said right portion of said
chassis;

an adjustment actuator for raising and lowering at least a portion of said chassis between a seated position and a standing
position and any intermediate positions therebetween;

at least two user propulsion wheels, each laterally outset relative to said chassis and affixed proximate to said rotating
structure, one of said at least two user propulsion wheels being rotatably affixed to said left rotating structure, and one
of said at least two user propulsion wheels being rotatably affixed to said right rotating structure;

a linkage system connecting one of said at least two user propulsion wheels with one of said two ground drive wheels at said
left portion of said chassis, and another linkage system connecting one of said at least two user propulsion wheels with one
of said two ground drive wheels at said right portion of said chassis;

directional support wheels rotatably affixed to a foot rest which is affixed to a frontal extension disposed at said front
portion of said chassis, wherein said directional support wheels include a caster structure for affixment of said directional
support wheels to said foot rest, and said frontal extension retracts said foot rest and said directional support wheels off
the ground during seated operation, and lowers said foot rest and said direction support wheels to contact the ground during
standing operation;

a set of stabilizing rear wheels situated structurally opposite said directional support wheels; and
wherein each said at least two ground drive wheels is rotatably affixed to said center portion of said chassis, respectively,
adjacent said left portion and said right portion between said directional support wheels and said stabilizing rear wheels,
as a means for maintaining a stable center of gravity of said wheelchair at said center portion of said chassis and for focusing
a locus of force at each said ground drive wheels at said center portion of said chassis during both seated operation and
standing operation.

US Pat. No. 9,394,338

GLUTATHIONE ANALOGS AND USES THEREOF

REGENTS OF THE UNIVERSITY...

1. A compound of formula I:
wherein:
each R1 is independently H, (C1-C6)alkyl, (C3-C8)cycloalkyl, aryl(C1-C6)alkyl, or heteroaryl(C1-C6)alkyl;

each R1a is independently H, (C1-C6)alkyl, (C3-C8)cycloalkyl, aryl(C1-C6)alkyl, or heteroaryl(C1-C6)alkyl;

R2 is OH, NH2, —O—C(?O)—R1a, —NH—C(?O)—R1a or —NH—C(?O)O—R1a;

Z is —NH—, —O—, or —S—;
X is —S— or absent, R3 is H, —(CH2)CH(NHR6)CO2H or

and R7 is H; or X is absent, and R3 and R7 together with the atoms to which they are attached form a heterocycle, wherein the heterocycle is optionally substituted with
one or more groups selected from oxo (?O), (C1-C6)alkyl, (C3-C8)cycloalkyl, aryl(C1-C6)alkyl and heteroaryl(C1-C6) alkyl;
each R4 is independently H, (C1-C6)alkyl, (C3-C8)cycloalkyl, aryl(C1-C6)alkyl, or heteroaryl(C1-C6)alkyl;

R5 is OH, NH2, —O—C(?O)—R1a, —NH—C(?O)—R1a or —NH—C(?O)O—R1a;

R6 is H, (C1-C6)alkyl or —C(?O)—R1; and

Y is —CH2—, —S— or NH;

or a salt thereof;
provided the compound of formula I is not a compound of formula:

US Pat. No. 9,360,543

SYSTEM AND METHOD FOR PARALLEL MAGNETIC RESONANCE IMAGE RECONSTRUCTION USING DIGITAL BEAMFORMING

REGENTS OF THE UNIVERSITY...

1. A method for producing an image of a subject with a magnetic resonance imaging (MRI) system, the steps of the method comprising:
a) acquiring data from the subject using an MRI system by generating radio frequency (RF) energy with at least one transmit
RF element and measuring magnetic resonance signals formed in response thereto with at least two receive RF elements;

b) determining a directivity for each of the at least two receive RF elements;
c) reconstructing an image corresponding to each of the at least two receive RF elements by reconstructing data acquired in
step a) by the respective receive RF element; and

e) producing an image of the subject by combining the images reconstructed in step c) using the directivities for the at least
two receive RF elements.

US Pat. No. 9,322,121

STITCHED STRETCH SENSOR

Regents of the University...

1. A system comprising:
a stitched sensor comprising a plurality of threads stitched to a textile in a stitch geometry, the plurality of threads comprising
a conductive thread defining a plurality of loops in the stitch geometry, wherein the stitch geometry is configured such that
an electrical property of the stitched sensor changes based on at least one of stretching or relaxation of the textile that
causes at least two loops of the plurality of loops to change between a first configuration in which the at least two loops
contact each other and a second configuration in which the at least two loops are separated from each other and do not overlap
each other.

US Pat. No. 9,222,999

MAGNETIC RESONANCE RELAXATION ALONG A FICTITIOUS FIELD

Regents of the University...

1. A magnetic resonance (MR) system comprising:
a driving module configured to apply a perturbation to a sample;
a processor configured to generate RF modulated pulses, the RF modulated pulses configured to define a plurality of at least
three different rotating frames of reference relative to the perturbation, the plurality of at least three different rotating
frames of reference including at least two frames in which each frame of the at least two frames includes a fictitious field
and wherein at least one fictitious field is time variant, the fictitious fields are produced by an interaction of the plurality
of the at least three different rotating frames of reference, and each different rotating frame is associated with an effective
field, wherein the fictitious fields and the effective fields are associated with the generated modulated pulses and the modulated
pulses are produced by a recursive expansion; and

a readout module coupled to the processor and configured to generate an output based on a relaxation of spins of the sample
as a function of the perturbation in order to display or store a magnetic resonance output with the readout module.

US Pat. No. 9,180,413

ONE-STEP SYNTHESIS OF MESOPOROUS PENTASIL ZEOLITE WITH SINGLE-UNIT-CELL LAMELLAR STRUCTURAL FEATURES

Regents of the University...

1. A material, comprising:
a plurality of zeolite particles each having a unit-cell structure that is lamellar and has a single unit-cell thickness in
at least one dimension,

wherein the zeolite particles are intergrown to define pores that extend between the intergrown zeolite particles and so that
the lamellar unit cells intersect perpendicular to one another, and

wherein the plurality of zeolite particles are either MFI zeolite particles or pentasil zeolite particles.

US Pat. No. 9,169,216

METHOD FOR PREPARATION OF 5-SUBSTITUTED PYRIMIDINES

Regents of the University...

1. A method for preparing a 5-acylpyrimidine comprising:
(a) reacting a pyrimidine of formula (II):

wherein X is halo or a sulfonate leaving group, and a compound of formula
(R1CH2)(Li+)x(M++)y(X?)z  (V)

wherein R1 is an organic group, M is a metal cation, each X is halo, and x, y and z are selected so that the net charge of the compound
(V) is 0, wherein the coupling is carried out in the presence of an effective catalytic amount of a complexed metal, to yield
a compound of formula VI;

and
(b) oxidizing the compound of formula (VI) to yield a 5-acylpyrimidine compound of formula (VII):

US Pat. No. 9,315,650

BIO-RENEWABLE PLASTICIZERS DERIVED FROM VEGETABLE OIL

Regents of the University...

1. A composition comprising estolide esters of vegetable oil fatty acid alkyl esters, where the vegetable oil has an unsaturation
of greater than 90 IV, the fatty acid alkyl esters comprise unsaturated and saturated fatty acid alkyl esters, and each unsaturated
fatty acid alkyl ester has greater than one estolide ester functionality on average.
US Pat. No. 9,186,340

ISCHEMIA/REPERFUSION PROTECTION COMPOSITIONS AND METHODS OF USING

Regents of the University...

1. A method for treating ischemic damage and/or reperfusion injury in an individual who is experiencing or has experienced
hemorrhagic external blood loss, comprising administering a composition comprising 4M D-beta-hydroxybutyrate and 43 mM melatonin
to said individual, thereby treating ischemic damage and/or reperfusion injury in said individual.

US Pat. No. 9,084,635

INTRAOPERATIVE SPINAL STABILIZATION

Regents of the University...

1. A spinal stabilization device comprising:
a clamp configured to engage a vertebra of a spine;
a first rail connected to the clamp and comprising a first plurality of spikes distributed longitudinally along the first
rail; and

a second rail extending from the clamp offset laterally from the first rail and comprising a second plurality of spikes distributed
longitudinally along the second rail,

wherein the first rail and the second rail are biased toward one another with the first plurality of spikes pointing toward
the second plurality of spikes, and

wherein the offset between the first rail and the second rail is in a range from approximately 7 to approximately 15 millimeters.
US Pat. No. 9,353,238

COMPOSITIONS INCLUDING POLY(HYDROXYALKANOATES) AND GRAPHENE

REGENTS OF THE UNIVERSITY...

1. A composite comprising:
poly(hydroxyalkanoate) (PHA); and
graphene, wherein said graphene comprises two-dimensional sheets and is atomically thick two-dimensional sheet composed of
sp2 carbon atoms arranged in a honeycomb structure.

US Pat. No. 9,240,799

SPIN-BASED LOGIC DEVICE

Regents of the University...

1. A device comprising:
a conductive layer configured to output a spin-current based on an analog input value;
a plurality of magnetoresistive devices, each configured to receive a different reference voltage on a first side and the
spin-current on a second side, wherein a magnetization state of each of the magnetoresistive devices is set by respective
reference voltages and the spin-current; and

an encoder configured to output a digital value including a plurality of digital bits that is a digital representation of
the analog input value based on the magnetization states of the magnetoresistive devices.

US Pat. No. 9,072,501

MICRO-ORIFICE SURGICAL ACCESS SYSTEM

Regents of the University...

1. A surgical access system comprising:
a port access device including:
a port member defining a central passageway extending along a central longitudinal axis;
a plurality of blades circumferentially arranged about the longitudinal axis to collectively define an access region open
to and extending distally from the central passageway, wherein each of the blades terminates at a tip opposite the port member;
and

an articulation mechanism including a drive collar and configured to define a first pivot point along a length of each of
the blades, each of the first pivot points establishing an axis of rotation that extends through the port member, the articulation
mechanism being operable to articulate the blades between:

a collapsed state in which the tips collectively define a first diameter,
an expanded state in which the tips collectively define a second diameter greater than the first diameter,
wherein the articulation mechanism is configured such that the blades rotate about the corresponding first pivot point, and
the first pivot points move longitudinally relative to the port member parallel with the longitudinal axis, in transitioning
between the collapsed and expanded states.

US Pat. No. 9,374,111

MULTI-STAGE CHARGE RE-USE ANALOG CIRCUITS

Regents of the University...

1. A method comprising:
receiving, by a passive analog circuit, an analog input signal;
processing, by the passive analog circuit, the analog input signal in a charge domain to generate an analog output signal,
including performing, by a capacitor in the passive analog circuit, one or more charge stealing operations to steal charge
away from a shared output of two or more capacitors of the passive analog circuit; and

outputting, by the passive analog circuit, the analog output signal in the charge domain.

US Pat. No. 9,191,831

NON-PARAMETRIC POWER SPECTRAL DENSITY (PSD) MAP CONSTRUCTION

Regents of the University...

1. A method comprising:
sensing a local radio-frequency (RF) interference spectrum at each of a plurality of sensors positioned at a plurality of
locations within a geographic region;

computing a non-parametric basis expansion model from the sensed RF interference spectrum, wherein the non-parametric basis
expansion model comprises a set of reference basis functions that represent a frequency distribution of the RF power and a
set of kernel-based interpolating functions that represent a physical distribution of the RF power throughout the geographic
region, and wherein the kernel-based interpolating functions are computed in the non-parametric basis expansion model as coefficients
to the reference basis functions and operate as bases weighting functions in the non-parametric basis expansion model; and

constructing, in accordance with the non-parametric basis expansion model, a power spectral density (PSD) map representative
of a distribution of RF power throughout the geographic region as a function of frequency and location.

US Pat. No. 9,356,238

REPLICATION OF PATTERNED THIN-FILM STRUCTURES FOR USE IN PLASMONICS AND METAMATERIALS

Regents of the University...

1. A method of making a patterned device, the method comprising:
providing one or more periodically distributed surface feature in a first silicon substrate to form a patterned template;
coating the patterned template with a metal to form a thin-film layer structure on the one or more periodically distributed
surface feature;

coating the thin-film layer structure with a material to form an adhesive layer;
attaching a second silicon substrate to the adhesive layer; and
separating the thin-film layer structure from the patterned template.

US Pat. No. 9,334,571

METHOD OF FORMING INDIVIDUAL METALLIC MICROSTRUCTURES

Regents of the University...

1. A method of making a plurality of three-dimensional metallic microstructures, the method comprising:
masking a silicon-based substrate with a mask having a plurality of apertures therethrough;
etching the masked substrate to form a plurality of shaped cavities within the substrate;
depositing a metallic layer over the mask and into the plurality of shaped cavities in contact with the substrate, and thus
forming a metallic structure within each of the cavities that is shaped by the shaped cavity;

removing the metallic layer from over the mask;
removing the mask from the substrate to provide a plurality of individual metallic microstructures.
US Pat. No. 9,468,669

METHODS TO TREAT DYSREGULATED BLOOD GLUCOSE DISORDERS

REGENTS OF THE UNIVERSITY...

1. A method for treating a dysregulated blood glucose disorder in a mammal in need thereof comprising administering an effective
amount of D-serine or a pharmaceutically acceptable salt thereof, D-cycloserine or a pharmaceutically acceptable salt thereof,
or glycine or a pharmaceutically acceptable salt thereof to the mammal in need thereof.
US Pat. No. 9,393,257

TALEN-BASED GENE CORRECTION

Regents of the University...

1. A composition comprising:
a nucleic acid encoding at least one TALEN protein, wherein the at least one TALEN protein is capable of inducing a site-specific
double stranded DNA break in a target gene in a cell, wherein the target gene is a COL7A1 gene; and

a nucleic acid donor sequence,
wherein the donor sequence is a template for correction of a genetic mutation in the Col7A1 target gene, and further wherein
the genetic mutation is capable of causing epidermolysis bullosa.

US Pat. No. 9,339,482

METHODS TO TREAT DYSREGULATED BLOOD GLUCOSE DISORDERS

REGENTS OF THE UNIVERSITY...

1. A method for treating a dysregulated blood glucose disorder in a mammal in need thereof comprising administering an effective
amount of an N-methyl-D-aspartate receptor activator or a pharmaceutically acceptable salt thereof to the mammal in need thereof.

US Pat. No. 9,251,438

CONVEX MINIMIZATION AND DATA RECOVERY WITH LINEAR CONVERGENCE

Regents of the University...

1. A method comprising:
receiving, with an image processing device, multidimensional image data that captures a set of one or more features visible
within a physical environment, wherein the image data comprising a set of data points conforming to a plurality of dimensions
(D) and including outlier data points; and

removing one or more objects from the image data by iteratively processing the set of data points with the image processing
device to compute a reduced data set representative of the set of data points of the image data, wherein the reduced data
set conforms to a subspace having a reduced number of dimensions (d) less than the plurality of dimensions (D) of the set
of data points of the image,

wherein iteratively processing the set of data points of the image data to compute the reduced data set comprises:
determining, for each iteration, a scaled version of the set of data points by re-computing a corresponding coefficient for
each of the data points as a function of a proximity of the data point to a current estimate of the subspace, and

computing, for each iteration, an updated estimate of the subspace based on a minimization of a sum of least squares of the
scaled version of the set of data points; and

processing, with the image processing device, the reduced data set representative of the image data to identify one or more
features within the physical environment.

US Pat. No. 9,123,538

SILICON NANOCRYSTAL INKS, FILMS, AND METHODS

REGENTS OF THE UNIVERSITY...

1. A silicon nanocrystal ink comprising partially halide-terminated nanocrystals of silicon or an alloy thereof in an organic
solvent that is effective to form a colloidal dispersion of the silicon nanocrystals.

US Pat. No. 9,121,016

COATINGS CONTAINING POLYMER MODIFIED ENZYME FOR STABLE SELF-CLEANING OF ORGANIC STAINS

Toyota Motor Corporation,...

1. A water-stabilized bioactive coating composition comprising:
a base;
an enzyme associated with said base;
said enzyme associated with one or more of branched eight-arm polyoxyethylene to form a chemically modified enzyme; and
a first polyoxyethylene associated with said base, said first polyoxyethylene independent of said enzyme; wherein said base,
said enzyme, and said first polyoxyethylene form a water-stabilized active coating composition.

US Pat. No. 9,101,276

ANALYSIS OF BRAIN PATTERNS USING TEMPORAL MEASURES

REGENTS OF THE UNIVERSITY...

1. A system for classifying neurophysiologic activity of a first subject, the system comprising:
a data input configured to receive brain activity data corresponding to an idle state of the brain of the first subject, the
brain activity data representing a time series of neurophysiologic activity acquired by a sensor system arranged to detect
spatial and temporal neural signaling in the subject utilizing magnetic fields produced in a multiplicity of brain regions;
and

a processor communicatively coupled to the data input, and programmed to:
process each set of brain activity data to produce a corresponding dynamic model of neural activity representing time-dependent
coupling between neural populations of the brain of the first subject, including:

processing the brain activity data to produce a prewhitened time series;
computing partial cross correlations of the prewhitened time series to produce estimates of strength and sign of signaling
between groups of the multiplicity of brain regions representing interactions of neural populations, based on an analysis
of covariance of at least one type of partial cross correlations selected from the group consisting of: (a) positive partial
cross correlations of the partial cross correlations of the prewhitened time series, and (b) negative partial cross correlations
of the partial cross correlations of the prewhitened time series;

performing a classification of the partial cross correlations to produce a measure of correlation of the brain activity data
to validated reference data corresponding to a plurality of different neurophysiologic conditions.

US Pat. No. 9,665,680

CELL-LEVEL SIGNAL ELECTROMIGRATION

Regents of the University...

1. A circuit design system comprising:
a simulator that determines an average charging current provided by each current insertion point in a cell and an average
charging current along a path in the cell between a reference pin position and a candidate pin position;

a candidate pin placement tester that updates the average charging current along the path by adding the average charging current
of each insertion point to the average charging current along the path to produce an updated average charging current along
the path and using the updated average charging current along the path to determine a performance parameter value for the
cell, wherein the performance parameter value comprises a time-to-failure for the cell; and

a pin invalidator that invalidates candidate pin positions that have a performance parameter value below a threshold, wherein
the pin invalidator sets the threshold by determining a candidate pin position for each cell in a circuit that provides a
best performance parameter value for the cell and selecting the worst of the best performance parameter value as the threshold.

US Pat. No. 9,425,738

SPIN CURRENT GENERATION WITH NANO-OSCILLATOR

Regents of the University...

1. A device comprising:
a spin channel to transport a spin current;
a nano-oscillator having a magnetization state that, in response to a DC input voltage or current, oscillates between a first
state and a second state and induces the spin current within the spin channel; and

a magnetoresistive device that receives the spin current from the nano-oscillator, the magnetoresistive device having a magnetization
state that is set to a parallel or anti-parallel state by the received spin current.

US Pat. No. 9,296,728

THERAPEUTIC COMPOUNDS

Regents of the University...

1. A compound of the formula:

or a salt thereof.

US Pat. No. 9,224,447

GENERAL STRUCTURE FOR COMPUTATIONAL RANDOM ACCESS MEMORY (CRAM)

Regents of the University...

1. A cell array comprising:
a logic connection line;
a plurality of bit selection lines;
a plurality of cells, each cell comprising:
a memory element connected to a respective bit selection line; and
a logic switching element that selectively connects the memory element to the logic connection line;
wherein when logic switching elements of multiple separate cells connect their respective memory elements to the logic connection
line, the memory elements connected to the logic connection line operate as a logic device with an output of the logic device
stored in one of the memory elements.

US Pat. No. 9,200,068

COMPOSITIONS AND METHODS RELATED TO TAUOPATHY

Regents of the University...

1. An antibody preparation comprising a monoclonal antibody that specifically binds to SEQ ID NO:11 and requires no amino
acid residues outside of SEQ ID NO:11 to specifically bind to SEQ ID NO:11.
US Pat. No. 9,187,529

CATIONIC PEPTIDES AND USE OF SUCH PEPTIDES FOR INHIBITING EXOTOXIN PRODUCTION

Regents of the University...

1. An isolated peptide wherein said peptide is from 10 to 50 amino acids in length, and wherein the percentage of positively
charged amino acids above the number of negatively charged amino acids is 15% or higher, and wherein the peptide comprises
an amino acid as set forth in SEQ ID NO:5 or SEQ ID NO:6.
US Pat. No. 9,469,797

PRESSURE-SENSITIVE ADHESIVES HAVING HIGH BIO-BASED CONTENT AND MACROMONOMERS FOR PREPARING SAME

Regents of the University...

1. A macromonomer comprising the ring-opening reaction product of (a) a hydroxy-functional, ethylenically unsaturated monomer,
(b) a bio-based monomer, and (c) a modifying monomer that lowers the Tg of the macromonomer relative to the Tg of the same
macromonomer prepared in the absence of the modifying monomer, wherein monomers (a), (b), and (c) are different from each
other.
US Pat. No. 9,395,369

GUINEA PIG CYTOMEGALOVIRUS (CIDMTR STRAIN)

REGENTS OF THE UNIVERSITY...

1. A method for testing the effectiveness of a vaccine or therapeutic composition in preventing or ameliorating re-infection
with cytomegalovirus comprising:
a. administering a first guinea pig cytomegalovirus (GPCMV) to a guinea pig,
b. administering a vaccine or therapeutic composition, and
c. administering a second GPCMV to the guinea pig,
wherein the first GPCMV is strain ATCC/22122 and the second GPCMV is strain CIDMTR or wherein the first GPCMV is strain CIDMTR
and the second GPCMV is strain ATCC/22122; and

wherein
(a) the CIDMTR strain is ATCC® deposit number PTA-120714;
(b) the CIDMTR strain has at least 99% identity to SEQ ID NO:1;
(c) the CIDMTR Strain comprises 1) a glycoprotein (GP) having greater than 94% sequence identity to GPCMV glycoprotein 131
(GP131) (SEQ ID NO:3); and 2) a GP having greater than 84% sequence identity to GPCMV glycoprotein 129 (GP129) (SEQ ID NO:2),
greater than 78% sequence identity to GP74 (gO) (SEQ ID NO:4), greater than 99% sequence identity to glycoprotein 55 (gB)
(SEQ ID NO:6), greater than 93% sequence identity to glycoprotein 73 (gN) (SEQ ID NO: 7), greater than 99% sequence identity
to glycoprotein 115 (gL) (SEQ ID NO:8), or greater than 82% sequence identity to GP75 (gH) (SEQ ID NO:5);

(d) the CIDMTR Strain comprises open reading frame gp147.1;
(e) the CIDMTR Strain comprises 1) a glycoprotein (GP) having greater than 93% sequence identity to glycoprotein 73 (gN) (SEQ
ID NO: 7); and 2) a GP having greater than 84% sequence identity to GPCMV glycoprotein 129 (GP129) (SEQ ID NO:2), greater
than 94% sequence identity to GPCMV glycoprotein 131 (GP131) (SEQ ID NO:3), greater than 78% sequence identity to GP74 (gO)
(SEQ ID NO:4), greater than 99% sequence identity to glycoprotein 55 (gB) (SEQ ID NO:6), greater than 99% sequence identity
to glycoprotein 115 (gL) (SEQ ID NO:8), or greater than 82% sequence identity to GP75 (gH) (SEQ ID NO:5); or

(f) the CIDMTR Strain comprises 1) a glycoprotein (GP) having greater than 99% sequence identity to glycoprotein 115 (gL)
(SEQ ID NO:8); and 2) a GP having greater than 84% sequence identity to GPCMV glycoprotein 129 (GP129) (SEQ ID NO:2), greater
than 94% sequence identity to GPCMV glycoprotein 131 (GP131) (SEQ ID NO:3), greater than 78% sequence identity to GP74 (gO)
(SEQ ID NO:4), greater than 99% sequence identity to glycoprotein 55 (gB) (SEQ ID NO:6), greater than 93% sequence identity
to glycoprotein 73 (gN) (SEQ ID NO: 7) or greater than 82% sequence identity to GP75 (gH) (SEQ ID NO:5).

US Pat. No. 9,388,218

PRRSV COMPOSITIONS

Regents of the University...

1. A composition comprising a combination of proteins and antigens of PRRS virus isolated from a population of cells infected
with PRRS virus, cellular components and a detergent used to extract or elute the proteins and antigens of PRRS virus and
cellular components from cells infected with PRRS virus, wherein the composition is prepared by
a) providing the population of cells that have been infected with PRRS virus, wherein said cells produce viral proteins and
antigens encoded by PRRS virus so that said cells produce cell-free PRRS virus into the culture medium,

b) isolating the PRRS virus infected cells, away from cell-free PRRS virus in the culture medium about the cells, to form
isolated cells containing cell associated viral proteins and antigens encoded by PRRS virus, and

c) extracting or eluting the isolated cells with a detergent containing solution to form an extract or eluate containing the
cell associated viral proteins and antigens along with cellular components,

to form a composition comprising PRRS virus proteins and antigens from PRRS virus infected cells.

US Pat. No. 9,745,530

PRODUCTION OF BIODIESEL FROM SCUM

Regents of the University...

1. A method for production of a biodiesel comprising:
(a) separating solids from a waste oil composition to provide a clarified waste oil composition;
(b) acidifying the clarified waste oil composition to produce an acidified oil composition comprising free fatty acids derived
from the waste oil composition;

(c) converting at least a portion of the free fatty acids in the acidified oil composition to glycerides to provide a glyceride
composition; and

(d) reacting at least a portion of the glycerides in the glyceride composition with methanol to form fatty acid methyl esters
to provide a biodiesel composition.

US Pat. No. 9,504,982

THERMOCHEMICAL REACTOR SYSTEMS AND METHODS

REGENTS OF THE UNIVERSITY...

1. A thermochemical reactor system comprising:
a carrier having a longitudinal axis and configured to rotate about the longitudinal axis, wherein the carrier defines an
opening through at least a portion thereof along the longitudinal axis;

a reactive element, wherein the carrier comprises the reactive element;
an energy transfer element disposed within at least a portion of the opening of the carrier in a coaxial configuration, wherein
the energy transfer element rotates within the opening of the carrier in a direction opposite to the rotation of the carrier;

an inlet gas management system to provide at least an oxidizing compound to the carrier; and
an outlet gas management system to receive at least a fuel compound from the carrier.

US Pat. No. 9,341,692

MAGNETIZATION TRANSFER AND OFF-RESONANCE PROTOCOLS IN NMR

Regents of the University...

1. A magnetic resonance system comprising:
a driver unit configured to apply a perturbation to a spin system; and
a processor coupled to the driver unit, the processor programmed to generate an initial pulse followed by a data acquisition
train, wherein the data acquisition train provides data based on magnetization transfer or off-resonance irradiation, and

wherein the processor is programmed to generate an image or spectra corresponding to the spin system in which magnetization
is initially aligned with a positive z-axis of the spin system and programmed to generate an image or spectra corresponding
to the spin system in which magnetization is initially aligned with a negative z-axis of the spin system.

US Pat. No. 9,424,647

VISUAL-BASED INERTIAL NAVIGATION

Apple Inc., Cupertino, C...

1. An electronic computing system for performing navigation, the electronic computing system comprising an electronic processor
and memory operable to implement a sliding-window inverse filter module, wherein the sliding-window inverse filter module
is configured to:
receive sensor measurements from a pre-processing module, wherein the sensor measurements comprise image data and inertial
data for a device;

transfer information, derived from the sensor measurements, from a first set of variables associated with a first window of
time to a second set of variables associated with a second window of time, wherein the first and second windows consecutively
overlap in time; and

output, to a post-processing module, a state of the device based on the transferred information,
wherein each window in the pair is associated with a corresponding first information matrix, and each first information matrix
is for a plurality of first variables representing a position and/or orientation of at least one object proximate to the device
and a plurality of second variables representing a state of the device at two or more points in time, and

wherein transferring the information comprises:
marginalizing at least a subset of the first variables associated with the first information matrix of the first window to
obtain a second information matrix, which still maintains the association with the plurality of second variables;

marginalizing a subset of the second variables associated with the second information matrix to obtain a third information
matrix; and

scaling the third information matrix to obtain a fourth information matrix,
wherein the fourth information matrix is a summarized representation of the information about the state of the device and
of the position and/or orientation of the objects proximate to the device at points in time when the first window and the
second window in the pair overlap.

US Pat. No. 9,249,424

INTRANASAL DELIVERY OF AAV ENCODING THERAPEUTIC ENZYMES TO THE CENTRAL NERVOUS SYSTEM FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES

Regents of the University...

1. A method to prevent, inhibit or treat one or more neurological signs or symptoms associated with a deficiency in alpha-L-iduronidase,
iduronate-2-sulfatase, N-acetyl-alpha-D-glucosaminidase, beta-galactosidase, or beta-glucuronidase in a mammal in, comprising:
intranasally administering to the mammal a composition comprising an amount of a recombinant adeno-associated virus vector
comprising an open reading frame encoding a lysosomal storage enzyme comprising alpha-L-iduronidase, iduronate-2-sulfatase,
N-acetyl-alpha-D-glucosaminidase, beta-galactosidase, or beta-glucuronidase, effective to prevent, inhibit or treat the one
or more neurological signs or symptoms associated with the deficiency.

US Pat. No. 9,060,713

SENSING TISSUE PROPERTIES

Regents of the University...

1. A medical system, comprising:
a medical instrument having a distal portion insertable into a body and toward a targeted tissue;
one or more tissue elasticity sensors coupled to the distal portion of the medical instrument, the one or more tissue elasticity
sensors transmitting sensor signals in response to application of a force on the targeted tissue in the body that causes a
displacement of the targeted tissue, wherein each of the tissue elasticity sensors includes two or more flexible membranes
having different stiffness properties; and

a control unit to determine both the Young's modulus of the targeted tissue and the shear modulus of the targeted tissue in
the body in response to the sensor signals after the application of the force on the targeted tissue that causes the displacement
of the targeted tissue.

US Pat. No. 9,614,633

ESTIMATING FREQUENCY-OFFSETS AND MULTI-ANTENNA CHANNELS IN MIMO OFDM SYSTEMS

Regents of the University...

1. A method comprising:
forming two or more blocks of output symbols for orthogonal frequency division multiplexing (OFDM) transmissions over two
or more antennas, wherein the forming comprises encoding two or more blocks of information-bearing symbols for transmissions
over the two or more antennas, and inserting null values within the two or more blocks of information-bearing symbols so that
the position of the null values switches among subcarriers over time; and

transmitting, via the two or more antennas, transmission signals in accordance with the two or more blocks of output symbols,
wherein the two or more blocks of output symbols include a first block of output symbols and a second block of output symbols,
and wherein transmitting the transmission signals comprises:

transmitting, via a first antenna of the two or more antennas, a first transmission signal in accordance with the first block
of output symbols; and

transmitting, via a second antenna of the two or more antennas, a second transmission signal in accordance with the second
block of output symbols.

US Pat. No. 9,430,839

UNSUPERVISED FRAMEWORK TO MONITOR LAKE DYNAMICS

Regents of the University...

1. A method of reducing processing time when assigning geographic areas to land cover labels using satellite sensor values,
the method comprising:
a processor receiving a feature value for each pixel in a time series of frames of satellite sensor values, each frame containing
multiple pixels and each frame covering a same geographic location such that for each sub-area of the geographic location
there is a time series of pixel feature values;

for each sub-area of the geographic location, assigning the sub-area to one of at least three land cover labels;
the processor determining a fraction function for a first sub-area assigned to a first land cover label, the fraction function
based on means of pixel feature values of a first cluster of sub-areas assigned to a second land cover label and means of
feature values of a second cluster of sub-areas assigned to a third land cover label; and

reassigning sub-areas that were assigned to the first land cover label to one of the second land cover label and the third
land cover label based on the fraction functions of the sub-areas.

US Pat. No. 9,957,324

ANTI-FLT-1 ANTIBODIES IN TREATING DUCHENNE MUSCULAR DYSTROPHY

Shire Human Genetic Thera...

1. A method of treating Duchenne Muscular Dystrophy (DMD) comprising administering to an individual who is suffering from or susceptible to DMD an effective amount of an anti-Flt-1 monoclonal antibody, or an antigen binding fragment thereof, such that at least one symptom of DMD is reduced in intensity, severity, or frequency, or has delayed onset, and wherein the anti-Flt-1 monoclonal antibody, or antigen binding fragment thereof, inhibits binding of VEGF to Flt-1 receptor.
US Pat. No. 9,624,472

PRODUCTION OF INSULIN PRODUCING CELLS

Regents of the University...

1. A method to provide pancreatic cells to a subject in need thereof comprising:
a) contacting the stem cells with at least one member of the TGF? family of cytokines and at least one member of the Wnt family
of proteins, wherein the stem cells are induced pluripotent stem (iPS) cells,

b) contacting the cells obtained from step a) with at least one member of the TGF? family of cytokines, at least one member
of the Wnt family of proteins, and an agent that inhibits sonic hedgehog activity; and

c) contacting the cells obtained from step b) with a member of the Epidermal growth factor (EGF) family of proteins; and
administering the cells so as to provide pancreatic cells in the subject.

US Pat. No. 9,580,534

BLOCK COPOLYMER MATERIALS FOR DIRECTED ASSEMBLY OF THIN FILMS

Wisconsin Alumni Research...

1. A method of formulating a block copolymer material for directed assembly, comprising:
forming a modified block copolymer including an A block and a B? block, wherein the B? block is a B-C statistical or random
copolymer,

wherein the interaction parameter (?) of the modified block copolymer is larger than that of PS-b-PMMA at a particular temperature
of assembly and wherein surface or interfacial energies of the A and B? blocks are commensurate with each other such that
the BCP system can assemble in a thin film with non-preferential wetting of domains of the A and B? blocks at the surface
or interface of the thin film.

US Pat. No. 9,475,698

HYDROTHERMAL CARBONIZATION OF SEWAGE WASTES

REGENTS OF THE UNIVERSITY...

1. A method of obtaining a phosphate from a sewage material, the method comprising:
subjecting a wet sewage material to a hydrothermal carbonization process to produce a hydrochar and an aqueous product stream;
isolating the hydrochar from the aqueous product stream;
treating at least a portion of the isolated hydrochar with an aqueous acid under conditions effective to provide an aqueous
phosphate material; and

isolating the acid-treated hydrochar from the aqueous phosphate material.

US Pat. No. 9,513,244

ULTRA-COMPACT, PASSIVE, VARACTOR-BASED WIRELESS SENSOR USING QUANTUM CAPACITANCE EFFECT IN GRAPHENE

Regents of the University...

1. A sensor comprising:
a graphene quantum capacitance varactor having a graphene layer, wherein capacitance of the graphene layer changes in response
to electrical charge collected proximate to the graphene layer; and

a readout circuit responsive to the capacitance of the graphene layer and configured to output a signal indicative of the
electrical charge.

US Pat. No. 9,505,789

CYCLIZATION METHODS

REGENTS OF THE UNIVERSITY...

1. A method comprising cyclizing a compound including three triple bonds, wherein two of the triple bonds are in a conjugated
butadiyne subunit at a temperature below about 300° C. to provide a polycyclic compound having four carbon atoms from the
two triple bonds that were in the conjugated butadiyne subunit present in a six-membered carbocyclic ring of the polycyclic
compound.

US Pat. No. 9,500,727

SYSTEM AND METHOD FOR CONTROL OF RF CIRCUITS FOR USE WITH AN MRI SYSTEM

Regents of the University...

1. A radio-frequency (RF) system for use with a magnetic resonance imaging (MRI) system during a imaging process of a subject,
the RF system comprising:
a radio frequency (RF) element configured to at least one of transmit RF energy to and receive RF energy from the subject
during the medical imaging process;

an array of reactive components coupled to the RF element and configured to adjust at least one of an impedance transformation
and a frequency tuning associated with the RF element;

a mismatch detector circuit configured to measure a reflected signal from the RF element using a coupler including a coupling
port and an isolated port separated by a desired phase shift providing isolation therebetween; and

a feedback circuit configured to receive an indication of the reflected signal from the mismatch detector circuit and automatically
determine at least one of an impedance adjustment and a frequency tuning to be implemented by adjusting the array of reactive
components based on the reflected signal to effectuate transmit-receive isolation.

US Pat. No. 9,198,959

ADENOVIRUS VACCINE VECTOR AND METHODS OF USE

Regents of The University...

1. A viral particle comprising a genetically modified polynucleotide, the genetically modified polynucleotide comprising:
an Ad40-based polynucleotide comprising a genetic modification that comprises:
a partially deleted Ad40 E1 coding region; or
a deletion of a regulatory polynucleotide sequence that is required for expression of the Ad40 E1 coding region; and
a heterologous polynucleotide.

US Pat. No. 9,121,887

HIGH MAGNETIC MOMENT PARTICLE DETECTION

Regents of the University...

1. A device comprising:
a sensor surface including a first conductive layer separated from a second conductive layer by an intermediary layer, a magnetization
direction of the first conductive layer and a magnetization direction of the second conductive layer having a ground state
orientation of approximately 0 degrees;

a pair of electrodes coupled to the sensor surface and wherein an electrical resistance difference between the pair of electrodes
is determined by a magnetic field proximate the sensor surface and wherein the sensor surface has an aspect ratio, corresponding
to a length and a width of the sensor surface, that is sufficiently small such that a magnetic dipole field of a nanoparticle
proximate the sensor surface is detectable as an electrical resistance difference between the pair of electrodes; and

wherein the sensor surface is configured to detect proximity of a high magnetic moment particle, and the particles have a
magnetic moment that is seven times greater than that of magnetic oxide nanoparticles at 10 Oe magnetic field.

US Pat. No. 9,878,045

TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION

Regents of the University...

1. A compound of formula I or a salt thereof:

wherein n is an integer from 1 to 2.

US Pat. No. 9,858,816

DETERMINING PARKING SPACE OCCUPANCY USING A 3D REPRESENTATION

Regents of the University...

1. A method comprising:
receiving a plurality of two dimensional images of a parking stall within a parking facility, wherein receiving the plurality
of two dimensional images includes receiving the plurality of images from a single imaging source that is movable along a
trajectory relative to the parking facility, and wherein the trajectory includes a predefined path;

generating a three dimensional representation of the parking stall using the plurality of two dimensional images and based
on association of matching portions in the plurality of two dimensional images;

registering the three dimensional representation to align with the parking facility; and
processing the three dimensional representation to determine occupancy of the parking stall, the parking stall having a boundary
relative to the parking facility.

US Pat. No. 9,492,271

SILICA-BASED COMPOSITE OCULAR DEVICE AND METHODS

REGENTS OF THE UNIVERSITY...

1. A corneal implant comprising a structure formed from an optically clear, biocompatible composite comprising a fibrillar
component and a silica component coating at least a portion of the fibrillar component.

US Pat. No. 9,296,730

AURORA KINASE INHIBITORS

Regents of the University...

1. A compound of formula I:
wherein:
ring A is substituted with one or more groups independently selected from hydroxy, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo;

R1 is H, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo; or R1 and R2 taken together are methylenedioxy or ethylenedioxy;

R2 is H, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo; or R1 and R2 taken together are methylenedioxy or ethylenedioxy; or R2 and R3 taken together are methylenedioxy or ethylenedioxy;

R3 is H, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo; or R2 and R3 taken together are methylenedioxy or ethylenedioxy; or R3 and R4 taken together are methylenedioxy or ethylenedioxy; and

R4 is H, halo, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, methylenedioxy, ethylenedioxy, or (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy is optionally substituted with one or more halo; or R3 and R4 taken together are methylenedioxy or ethylenedioxy;

or a salt thereof.

US Pat. No. 9,885,621

STITCHED STRETCH SENSOR

Regents of the University...

1. A stitched sensor comprising:
a plurality of threads stitched to a textile in a stitch geometry, the plurality of threads comprising a conductive thread,
wherein the stitch geometry is configured such that a resonance of the stitched sensor changes based on at least one of stretching
and relaxation of the textile.

US Pat. No. 9,863,985

STATE ESTIMATION OF ELECTRICAL POWER NETWORKS USING SEMIDEFINITE RELAXATION

Regents of the University...

1. A method for estimating a state for each of a plurality of alternating current (AC) electrical power buses within a power
grid, the method comprising:
receiving, with an energy management system for the power grid, measurements of an electrical characteristic from a plurality
of measurement units (MUs) positioned at a subset of the power buses within the power grid;

processing the measurements of the electrical characteristic with the energy management system to compute an estimate of the
electrical characteristic currently occurring at each of the power buses within the power grid, the estimates of the electrical
characteristic being nonlinearly related to the measurements of the electrical characteristic, wherein processing the measurements
of the electrical characteristic comprises:

applying semidefinite relaxation to compute a semidefinite programming model for the power buses within the power grid that
linearly relates the estimates for the electrical characteristic to the measurements of the electrical characteristic; and

iteratively processing the measurements of the electrical characteristic in accordance with the semidefinite programming model
to compute a convex minimization as a solution for the estimates of the electrical characteristic; and

controlling operation of one or more of the power buses based on the computed estimates.

US Pat. No. 9,847,471

METHOD AND REMOTELY ADJUSTABLE REACTIVE AND RESISTIVE ELECTRICAL ELEMENTS

Regents of the University...

1. A method comprising:
providing an RF circuit in a remote environment, wherein the RF circuit includes an electrical component having a characteristic
impedance at a resonance frequency of the RF circuit in the remote environment;

changing a characteristic of the remote environment that affects the characteristic impedance and the resonance frequency
of the RF circuit;

sensing a parameter of the RF circuit and generating an electrical feedback signal based on the sensed parameter; and
based on the electrical feedback signal, automatically changing the electrical component to adjust both the characteristic
impedance and the resonance frequency.

US Pat. No. 9,841,480

LOCALIZATION OF MAGNETIC PARTICLES BY MEANS OF SWIFT-MRI

Regents of the University...

1. A system comprising:
a magnetic resonance scanner; and
a processor coupled to the scanner and configured to generate magnetic resonance (MR) image data, the MR image data including
complex data having a first component and a second component for a subject, the processor configured to generate a first image
using the first component and generate a second image using the second component, the MR image data acquired in a time-share
mode and substantially simultaneous with excitation, the excitation including a short T2 sensitive sequence provided by the scanner, and wherein the first image corresponds to anatomy of the subject and the second
image corresponds to a magnetic material within the subject, the first image different from the second image, and the processor
configured to identify a position of the magnetic material within the subject based on the second image.

US Pat. No. 9,469,879

LYMPHOMA PROGNOSTIC METHODS AND KITS

REGENTS OF THE UNIVERSITY...

1. A method to distinguish lymphomas comprising:
analyzing a tumor tissue sample from a subject for expression of CD28, ABCA5, CCDC3, and SMOC2,
calculating an expression ratio between CD28 and ABCA5;
calculating an expression ratio between CCDS3 and SMOC2;
wherein:
a CD28:ABCA5 expression ratio greater than 1.0 in the tumor sample is indicative of a T-cell tumor;
a CD28:ABCA5 expression ratio less than 1.0 in the tumor tissue sample is indicative of a B-cell tumor;
and if a T-cell tumor is indicated, wherein:
a CCDC3:SMOC2 expression ratio of greater than 1.0 is indicative of a low grade T-cell tumor; and
a CCDC3:SMOC2 expression ratio of less than 1.0 is indicative of a high grade T-cell tumor.

US Pat. No. 9,403,778

AGENTS THAT PREVENT OR REPAIR SKIN DAMAGE

Regents of the University...

1. A compound of formula I:
wherein:
each R1 is independently H, (C1-C6)alkyl, (C3-C7)carbocycle or RaC(?O)—, and the two R4 groups together form a —(C3-C8)alkyl-group, a —(C2-C6)alkyl-Y—(C2-C6)alkyl-group or a —(C1-C6)alkyl-Y?—(C1-C6)alkyl-group; or

each R4 is independently H, (C1-C6)alkyl, (C3-C7)carbocycle or RaC(?O)—, and the two R1 groups together form a —(C3-C8)alkyl-group, a —(C2-C6)alkyl-Y—(C2-C6)alkyl-group or a —(C1-C6)alkyl-Y?—(C1-C6)alkyl-group; or

the two R4 groups together form a —(C3-C8)alkyl-group, a —(C2-C6)alkyl-Y—(C2-C6)alkyl group or a —(C1-C6)alkyl-Y?—(C1-C6)alkyl-group and the two R1 groups together form a —(C3-C8)alkyl-group, a —(C2-C6)alkyl-Y—(C2-C6)alkyl-group or a —(C1-C6)alkyl-Y?—(C1-C6)alkyl-group;

the dashed bonds labeled “a” are absent and the dashed bonds labeled “b” are double bonds; or all the dashed bonds are single
bonds;

R2 is H, (C1-C6)alkyl or aryl, wherein aryl is optionally substituted with one or more Z1 groups;

R3 is H, (C1-C6)alkyl or aryl, wherein aryl is optionally substituted with one or more Z1 groups;

Y is O, S, NH, NRc, P, P(?O) or POH;

Y? is Si(Rb)2 or —Si(Rb)2—O—Si(Rb)2—;

each Ra is independently (C1-C6)alkyl, (C3-C7)carbocycle or aryl, wherein aryl is optionally substituted with one or more Z1 groups;

each Rb is independently (C1-C6)alkyl, (C3-C7)carbocycle or aryl, wherein aryl is optionally substituted with one or more Z1 groups;

each Rc is independently Rg or a C1-C18 saturated or unsaturated carbon chain that is optionally substituted with one or more groups independently selected from oxo
(?O), hydroxy, mercapto, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkanoyloxy, NRdRe, carboxy, and aryl, wherein any aryl of Rc is optionally substituted with one or more Rf;

each Rd and Re is independently selected from H, (C1-C6)alkyl, (C1-C6)alkanoyl, phenyl, benzyl, and Rg;

each Rf is independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkanoyloxy, —C(?O)-phenyl, and —C(?O)CH2C(?O)-phenyl, wherein any phenyl is optionally substituted with one or more groups independently selected from (C1-C6)alkyl, —SO3H, and (C1-C6)alkoxy;

each Rg is


each Z1 is independently selected from (C1-C6)alkyl, halogen, —CN, —ORn1, —NRq1Rr1, —NRn1CORp1, —NRn1CO2Rp1, NO2, —C(O)Rn1, —C(O)ORn1 and —C(O)NRq1Rr1, wherein any (C1-C6)alkyl of Z1 is optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) halogen;

each Rn1 is independently selected from H and (C1-C6)alkyl, wherein any (C1-C6)alkyl of Rn1 is optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) halogen;

each Rp1 is independently (C1-C6)alkyl; and

Rq1 and Rr1 are each independently selected from H and (C1-C6)alkyl or Rq1 and Rr1 together with the nitrogen to which they are attached form a piperidine, pyrrolidine, morpholine, azetidine, thiomorpholine,
piperazine or 4-methylpiperazine;

or a salt thereof.

US Pat. No. 10,148,092

REAL TIME VOLTAGE REGULATION THROUGH GATHER AND BROADCAST TECHNIQUES

ALLIANCE FOR SUSTAINABLE ...

1. A device comprising:at least one processor configured to:
receive a plurality of voltage measurements, wherein voltage measurements in the plurality of voltage measurements correspond to respective nodes in a plurality of nodes of a distribution network;
determine, for each respective node in the plurality of nodes:
a respective value of a first voltage-constraint coefficient, based on a respective previous value of the first voltage-constraint coefficient, a respective minimum voltage value for the respective node, and a respective voltage measurement in the plurality of voltage measurements that corresponds to the respective node; and
a respective value of a second voltage-constraint coefficient based on a respective previous value of the second voltage-constraint coefficient, a respective maximum voltage value for the respective node, and the respective voltage measurement, wherein the respective minimum voltage value for the respective node and the respective maximum voltage value for the respective node represent a defined allowable voltage range at the respective node; and
cause at least one inverter-interfaced energy resource in a plurality of inverter-interfaced energy resources that are connected to the distribution network to modify an output power of the at least one inverter-interfaced energy resource based on the respective value of the first voltage-constraint coefficient for each respective node and the respective value of the second voltage-constraint coefficient for each respective node.
US Pat. No. 9,849,171

PRRSV COMPOSITIONS

Regents of the University...

1. A vaccine composition, comprising PRRS virus polypeptides, virus-infected cell lysate, a detergent, and an adjuvant.

US Pat. No. 9,812,457

ULTRA HIGH DENSITY INTEGRATED COMPOSITE CAPACITOR

REGENTS OF THE UNIVERSITY...

1. An integrated circuit (IC) chip comprising:
a metal-oxide-silicon (MOS) capacitor comprising a MOS transistor having a drain terminal, a source terminal, a gate terminal,
and a body terminal,

wherein the drain terminal and the source terminal are not electrically connected to any other node within the IC chip so
as to be electrically floating within the IC chip, and

wherein the gate terminal and the body terminal of the MOS transistor form respective first and second terminals of the MOS
capacitor;

a first conductor coupled to the gate terminal; and
a second conductor coupled to the body terminal,
wherein the first and second conductors set a potential at the gate terminal relative to a potential at the body terminal
to configure and operate the MOS capacitor in an accumulation mode.

US Pat. No. 9,768,005

ELECTROSPRAY IONIZER FOR MASS SPECTROMETRY OF AEROSOL PARTICLES

MSP Corporation, Shorevi...

1. A system for electrospray ionization of species in aerosol particles, comprising:
a source for providing a sample of aerosol particles;
an aerosol deposition apparatus including:
a chamber for electrically charging the sample of aerosol particles; and
a nozzle for directing the sample of aerosol particles to an electrospray tip;
a solvent delivery mechanism for delivering a liquid to the electrospray tip; and
a high-voltage source for setting the electrospray tip at a high voltage, in order to enable the release of charged droplets
carrying dissolved contents of the aerosol particles.

US Pat. No. 9,726,742

SYSTEM AND METHOD FOR ITERATIVELY CALIBRATED RECONSTRUCTION KERNEL FOR ACCELERATED MAGNETIC RESONANCE IMAGING

Regents of the University...

1. A method for reconstructing an image using a magnetic resonance imaging (MRI) system, the steps of the method comprising:
a) acquiring, using the MRI system, first k-space data from a plurality of different slice locations, wherein spins in each
slice location are excited using a single band radio frequency (RF) excitation pulse;

b) acquiring, using the MRI system, second k-space data from the plurality of different slice locations, wherein spins in
the plurality of different slice locations are excited using a multiband RF excitation pulse;

c) generating an initial reconstruction kernel from the first k-space data acquired in step a);
d) producing an initial image for each of the multiple slice locations by applying the initial reconstruction kernel generated
in step c) to the second k-space data acquired in step b);

e) producing an updated reconstruction kernel by deriving one of phase information and magnitude information from the initial
images produced in step d), generating updated k-space data by applying the derived one of phase information and magnitude
information to the first k-space data, and generating the updated reconstruction kernel from the updated k-space data; and

f) producing an image for each slice location by applying the updated reconstruction kernel to the second k-space data acquired
in step b).

US Pat. No. 9,655,562

SYSTEM AND METHOD FOR PATIENT-SPECIFIC PLANAR VISUALIZATION OF VOLUMETRIC MRI DATA

Regents of the University...

1. A method for evaluating tissue states using a magnetic resonance imaging (MRI) system, the method comprising:
acquiring, with an MRI system, T2* data from a portion of a subject including tissue surrounding a joint;
generating T2* maps based on the T2* data;
registering the T2* maps with 3-D anatomical MRI data;
segmenting the 3-D anatomical MRI data in an ROI;
generating a 3-D anatomic volume of at least the ROI;
flattening the 3-D anatomic volume into a 2-D flattened image; and
presenting the registered T2* maps on the 2-D flattened image.

US Pat. No. 9,647,745

CHANNEL TRACKING AND TRANSMIT BEAMFORMING WITH FRUGAL FEEDBACK

Regents of the University...

1. A method comprising:
sending, through a wireless communication channel by a transmitting device having multiple antennas, a pilot signal in accordance
with a first set of transmission parameters, wherein the first set of transmission parameters is determined based on a first
estimated state of the channel;

receiving, by the transmitting device, channel state feedback from a receiving device, wherein the channel state feedback
comprises a quantized representation of a difference between the pilot signal received by the receiving device and a pilot
signal predicted by the receiving device to be received based on a current estimate of the channel determined by the receiving
device, and wherein the quantized representation comprises at least a first binary digit representing a quantization of a
real part of the difference and at least a second binary digit representing a quantization of an imaginary part of the difference;

determining, by the transmitting device and based on the channel state feedback, an updated estimated state of the wireless
communication channel; and

sending, by the transmitting device and via the wireless communication channel, one or more data symbols in accordance with
a second set of transmission parameters, wherein the second set of transmission parameters is determined based on the updated
estimated state of the channel.

US Pat. No. 9,555,074

ANNEXIN II COMPOSITIONS

Regents of the University...

1. A composition comprising:
at least one annexin II monomer component consisting of:
at least one 36 kDa annexin II monomer, or
a fragment of the 36 kDa annexin II monomer that comprises SEQ ID NO:7;
at least one antigen; and
an adjuvant coupled to the annexin II monomer component.

US Pat. No. 9,549,744

SPINAL PROBE WITH TACTILE FORCE FEEDBACK AND PEDICLE BREACH PREDICTION

Regents of the University...

1. A spinal probe comprising:
a handle;
a shaft coupled to the handle;
a force sensor configured to detect one or more forces applied to a tip of the shaft in a plane orthogonal to the shaft; and
a controller configured to:
compare the one or more forces to a control limit, and
provide an alert to a user indicating that the tip of the shaft is predicted to breach a cortex of a pedicle of a patient
based on the one or more forces exceeding the control limit.

US Pat. No. 9,511,185

INTRAVENOUS LINE LIFTER DEVICES, SYSTEMS AND METHODS

REGENTS OF THE UNIVERSITY...

1. An intravenous line lifter system for supporting one or more IV lines that extend between a patient and patient care equipment,
the intravenous line lifter system comprising:
a first elongated support member having a first end and a second end, wherein the first elongated support member is selectively
couplable to a support for the patient care equipment;

a second elongated support member having a first end and a second end, wherein the first end of the second elongated support
member is permanently fixedly coupled to the second end of the first elongated support member;

a first line retention device coupled to the first elongated support member between the first and second ends of the first
elongated support member; and

a second line retention device coupled to the second elongated support member proximate the second end of the second elongated
support member.

US Pat. No. 9,505,778

MONOMERS, POLYMERS AND ARTICLES CONTAINING THE SAME FROM SUGAR DERIVED COMPOUNDS

REGENTS OF THE UNIVERSITY...

1. A compound of formula V below:
where R and R? are independently selected from the following:

in which R1 is independently selected from:


where X is a linking group;
n is an integer greater than or equal to 1; and
R2 is hydrogen, or an alkyl.

US Pat. No. 9,493,757

MODIFIED FACTOR VII OR FACTOR VIIA POLYPEPTIDES

Regents of the University...

1. A Factor VII or Factor VIIa polypeptide comprising a modified GLA domain that enhances membrane binding affinity of said
polypeptide relative to a corresponding native Factor VII or Factor VIIa polypeptide, said modified GLA domain comprising
at least one amino acid substitution at position 33, 34, or 35, wherein amino acid positions of the Factor VII or Factor VIIa
polypeptide are numbered according to SEQ ID NO:3.

US Pat. No. 9,478,038

UNSUPERVISED SPATIO-TEMPORAL DATA MINING FRAMEWORK FOR BURNED AREA MAPPING

Regents of the University...

1. A method of reducing processing time required to identify locations burned by fire, the method comprising:
receiving a feature value for each pixel in an image, each pixel representing a sub-area of a location;
grouping pixels based on similarities of the feature values to form candidate burn events;
for each candidate burn event, determining a probability that the candidate burn event is a true burn event based on at least
one further feature value for each pixel in the candidate burn event; and

removing candidate burn events that have a probability below a threshold from further consideration as burn events to produce
a set of remaining candidate burn events.

US Pat. No. 9,467,178

PSEUDO TRUE TIME DELAY FOR MULTI-ANTENNA SYSTEMS

Regents of the University...

1. A method comprising:
receiving, by two or more passive analog circuits, one or more analog input signals;
processing, by the two or more passive analog circuits, the one or more analog input signals in a charge domain to generate
one or more analog output signals, including performing, by the two or more passive analog circuits, at least one of spatial
filtering and spectral filtering of the one or more analog signals, and further including performing, by a capacitor in the
two or more passive analog circuits, one or more charge stealing operations to steal charge away from a shared output of two
or more capacitors of the two or more passive analog circuits; and

outputting, by the two or more passive analog circuits, the one or more analog output signals in the charge domain, wherein
the one or more passive analog circuits are included within a charge re-use analog Fourier transform (CRAFT) circuit.

US Pat. No. 9,858,665

MEDICAL IMAGING DEVICE RENDERING PREDICTIVE PROSTATE CANCER VISUALIZATIONS USING QUANTITATIVE MULTIPARAMETRIC MRI MODELS

Regents of the University...

1. A method comprising:
receiving, by a computing device, a first parametric map that maps imaged tissue of a patient using values of a first parameter,
and a second parametric map that maps the imaged tissue using values of a second parameter, wherein the first parametric map
and the second parametric map are generated from medical imaging data for the imaged tissue;

applying, by the computing device, a multiparametric model to the first parametric map and the second parametric map to generate
a Composite Biomarker Score (CBS) map that maps the imaged tissue using a respective CBS value for one or more voxels of the
imaged tissue, wherein the multiparametric model specifies a multiparametric operation based on at least the first parameter
and the second parameter that is based on co-registered histopathology data and respective sets of medical imaging training
data;

determining, by the computing device, locations of the CBS map that correspond to CBS values that satisfy a threshold;
generating, by the computing device, a visual indication of the determined locations of the CBS map as regions of the imaged
tissue predicted to include cancer; and

outputting, by the computing device, the visual indication.

US Pat. No. 9,763,055

TRAVEL AND ACTIVITY CAPTURING

Regents of the University...

1. A mobile device comprising:
a positioning module sampling at least a position of the mobile device at a sampling rate when active and providing values
comprising at least the position of the mobile device, wherein the positioning module provides values comprising at least
one of velocity values and acceleration values for the mobile device;

a processor generating features from the provided values, applying the features to a model to determine a travel mode for
each of a collection of respective time points, and smoothing the travel modes for the collection of respective time points
to identify a travel mode for a trip segment for the mobile device, wherein generating features comprises generating at least
a first set of features from the values for a first time interval and a second set of features from the values for a second
time interval and wherein applying the features to a model comprises applying at least the first set of features and the second
set of features to the model to determine a travel mode for a single point in time.

US Pat. No. 9,651,508

THERMAL CONTRAST ASSAY AND READER

Regents of the University...

1. A thermal contrast assay reader comprising an energy source, a sensor, I/O circuitry and an opening to receive an assay
strip, the reader configured to convert the sensor results to an output signal upon activation of the energy source onto the
test region of the assay strip, wherein the sensor is an infrared sensor configured to measure thermal contrast in the test
region of the assay strip.

US Pat. No. 9,610,061

VASCULAR CHARACTERIZATION USING ULTRASOUND IMAGING

REGENTS OF THE UNIVERSITY...

1. A system for vascular imaging, comprising:
one or more ultrasound transducers, wherein the one or more transducers are configured to deliver ultrasound energy to a vascular
region resulting in pulse-echo data therefrom; and

processing apparatus configured to:
control the capture of pulse-echo data at a frame rate such that measured displacement of a vessel wall defining at least
one portion of a blood vessel in the vascular region and measured average blood flow through the at least one portion of the
blood vessel have a quasi-periodic profile over time to allow motion tracking of both the vessel wall and the blood flow simultaneously,
wherein the frame rate is at least greater than 100 frames per second;

generate strain and shear strain image data for the region in which the at least one portion of the vessel is located using
speckle tracking, wherein the speckle tracking comprises using multi-dimensional correlation of pulse-echo data of one or
more speckle regions undergoing deformation in the region in which the at least one portion of a blood vessel is located,
wherein the multi-dimensional correlation comprises determining a cross-correlation peak for the sampled pulse-echo data based
on phase and magnitude gradients of the cross-correlated pulse-echo data;

simultaneously measure displacement of a vessel wall defining at least one portion of a blood vessel in the vascular region
and average blood flow through the at least one portion of the blood vessel based on the strain and shear strain image data;

identify at least one vascular characteristic of the vascular region in which at least one portion of a blood vessel is located
based on the strain and shear strain image data and the simultaneously measured displacement of the vessel wall defining the
at least one portion of a blood vessel in the vascular region and average blood flow through the at least one portion of the
blood vessel, wherein the at least one vascular characteristic comprises a structural characteristic associated with the blood
vessel, wherein the structural characteristic identified comprises one or more vessel wall boundaries; and

modify, when using the speckle tracking, a characteristic of at least one of the one or more speckle regions being tracked
based on the one or more vessel wall boundaries identified such that the at least one speckle region is entirely within or
outside of the vessel wall.

US Pat. No. 9,401,306

SELF-ALIGNED CAPILLARITY-ASSISTED MICROFABRICATION

REGENTS OF THE UNIVERSITY...

1. A method for manufacturing an electronic device, comprising:
providing a substrate having a microchannel and a reservoir in communication with the microchannel; and
disposing a first liquid composition comprising a liquid carrier and a first electronic material in the reservoir to cause
the first liquid composition to move via capillarity through the microchannel.

US Pat. No. 9,874,203

DEVICES HAVING A VOLUME-DISPLACING FERROFLUID PISTON

Regents of the University...

1. A device for use in compressing and/or expanding a working fluid comprising:
a container;
a piston having a piston face, the piston face and the container defining an interior cavity having a volume that varies in
response to movement of the piston relative to the container;

working fluid contained in the interior cavity;
ferrofluid contained in the interior cavity; and
at least one magnetic component having a magnetic field that exerts magnetic forces on the ferrofluid that stabilize the ferrofluid
in a subset of the interior cavity, wherein the working fluid is displaced within the interior cavity by the ferrofluid.

US Pat. No. 9,658,070

INVERSE SLIDING-WINDOW FILTERS FOR VISION-AIDED INERTIAL NAVIGATION SYSTEMS

Regents of the University...

1. A vision-aided inertial navigation system comprising:
at least one image source to produce image data along a trajectory of the vision-aided inertial navigation system (VINS) within
an environment, wherein the image data contains a plurality of features observed within the environment at a plurality of
poses of the VINS along the trajectory;

an inertial measurement unit (IMU) to produce IMU data indicative of motion of the vision-aided inertial navigation system;
and

a hardware-based processing unit comprising an estimator that determines, based on the image data and the IMU data, estimates
for at least a position and orientation of the vision-aided inertial navigation system for a plurality of poses of the VINS
along the trajectory,

wherein the estimator determines the estimates by:
classifying, for each of the poses, each of the features observed at the respective pose into either a first set of the features
or a second set of the features,

maintaining a state vector having states for a position and orientation of the VINS and for positions with the environment
for the first set of features for a sliding window of two or more of the most recent poses along the trajectory without maintaining
states for positions of the second set of features within the state vector, and

applying an inverse sliding window filter to compute constraints between the poses within the sliding window based on the
second set of features and compute, in accordance with the constraints, the state estimates within the state vector for the
sliding window.

US Pat. No. 9,556,488

SPINOCEREBELLAR ATAXIA TYPE 8 AND METHODS OF DETECTION

REGENTS OF THE UNIVERSITY...

1. A method for sequencing a SCA8 coding sequence in a human subject, comprising:
(a) providing a first reaction mixture comprising a DNA molecule in a biological specimen from a human subject and a first
primer pair, wherein the DNA molecule comprises a SCA8 coding sequence, and wherein the primers in the first primer pair hybridize
to a nucleotide sequence selected from the group consisting of nucleotides 1-448 and nucleotides 726-1159 of SEQ ID NO:1 or
complements thereof, nucleotides 1-1070 and nucleotides 1350-1472 of SEQ ID NO:2 or complements thereof, and nucleotides 1-636
and nucleotides 915-1037 of SEQ NO:3 or complements thereof;

(b) amplifying the SCA8 coding sequence from the human subject to produce a first amplified DNA fragment;
(c) providing a second reaction mixture comprising the first amplified DNA and a second primer pair;
(d) amplifying the SCAB coding sequence to produce a second amplified DNA, fragment; and
(e) sequencing the second amplified DNA fragment.
US Pat. No. 9,526,747

USE OF MULTIPOTENT ADULT STEM CELLS IN TREATMENT OF MYOCARDIAL INFARCTION AND CONGESTIVE HEART FAILURE

Regents of the University...

1. A method of providing cardiac muscle to a subject in need thereof, said method comprising administering to the subject,
in an amount effective to provide new cardiac muscle, isolated expanded human multipotent non-ES, non-germ cells that express
telomerase, have the capacity to undergo 40 cell doublings in culture and have a normal karyotype, wherein the existing cardiac
muscle is damaged by disease or injury.

US Pat. No. 9,508,945

SPECTRALLY TUNABLE BROADBAND ORGANIC PHOTODETECTORS

Regents of the University...

1. A photodetector device comprising:
a plurality of organic photodetector subcells arranged in a stack, each organic photodetector subcell being configured to
generate an electrical current in response to absorbing light over a corresponding range of wavelengths,

wherein each organic photodetector subcell comprises a photoactive region composed of an intimate mixture of at least one
electron donor material and at least one electron acceptor material, and wherein the photoactive region of each organic photodetector
subcell in the stack is in direct physical contact with the photoactive region of at least one other organic photodetector
subcell in the stack.

US Pat. No. 9,239,319

VALVE AND SPLITTING SYSTEM FOR MULTI-DIMENSIONAL LIQUID ANALYSIS

Regents of the University...

13. A multi-dimensional liquid analysis system, comprising:
a first separation system including a first separation column for chromatographically separating a liquid mobile phase into
a first dimension outflow having a first outflow rate;

a flow splitter for separating the first dimension outflow into a first split outlet flow and a second split outlet flow;
a second separation system including a second separation column for chromatographically separating the second split outlet
flow; and

a flow control pump fluidly coupled to the flow splitter and configured to withdraw the second split outlet flow from the
flow splitter at a controlled withdrawal flow rate to obtain a representative sampling of compounds in the first dimension
outflow, wherein the controlled withdrawal flow rate defines a first split outlet flow rate as the difference between the
first outflow rate and the withdrawal flow rate, wherein the withdrawal flow rate is controlled by:

Fc?VL/(T2a+T2e)
wherein,
Fc=controlled flow rate at syringe pump flow stream;

VL=volume of sample loop;

T2a=analysis time of second dimension chromatograph; and

T2e=equilibration time of second dimension.

US Pat. No. 9,852,637

VEHICLE-TO-VEHICLE CONGESTION MONITORING USING AD HOC CONTROL

Regents of the University...

1. A vehicle-to-vehicle communication unit comprising:
a vehicle communication transceiver that transmits messages from a first vehicle that the vehicle communication transceiver
is installed in to other vehicles and that receives, while the first vehicle is moving on a roadway, at least one safety message
from a second vehicle positioned ahead of the first vehicle on the roadway that indicates that the second vehicle has decreased
its velocity;

a processor that, based on the safety message, generates a message for the other vehicles indicating that the vehicle-to-vehicle
communication unit has designated itself as an ad hoc host for determining information about a congestion area on a roadway
and provides the generated message to the vehicle communication transceiver, which transmits the generated message to the
other vehicles.

US Pat. No. 9,850,497

GENE TARGETING METHODS AND TOOLS

Regents of the University...

1. An in vitro method to correct a dysfunctional gene, wherein the dysfunction is caused by a genetic mutation, the method
comprising: introducing one or more nucleic acids encoding a TALEN and a nucleic acid donor sequence into a cell comprising
said dysfunctional gene, wherein the TALEN comprises a plurality of TAL effector sequences that can bind to a target site
of insertion in the dysfunctional gene,
wherein said nucleic acid donor sequence comprises a stop codon and a nucleic acid encoding a wild-type, functional coding
region of said dysfunctional gene flanked by sequences homologous to the target site of insertion, wherein the cell expresses
said TALEN and said TALEN introduces a site-specific double stranded break at the target site of insertion in said dysfunctional
gene, thereby introducing a stop codon into the dysfunctional gene in the cell and introducing a wild-type, functional coding
region of said dysfunctional gene into said cell.

US Pat. No. 9,660,582

SPIN CURRENT GENERATION WITH NANO-OSCILLATOR

Regents of the University...

6. A device comprising:
a nano-oscillator;
a spin channel coupled to the nano-oscillator, the spin channel configured to receive an input current and output amplified
current;

a first source configured to apply DC input voltage or current to the nano-oscillator to oscillate a magnetization state of
the nano-oscillator between a first state and a second state and induce a spin current in the spin channel; and

a second source configured to apply a gate voltage or current to the spin-channel to amplify the input current received by
the spin channel with the spin current to generate the amplified current.

US Pat. No. 9,623,035

TRIPTOLIDE PRODRUGS

Regents of the University...

1. A method for inhibiting cancer cell growth in HSP70-expressing cancer in a mammal comprising administering to the mammal
a compound of formula I:
wherein:
each R1 is independently H, (C1-C6)alkyl, aryl(C1-C6)alkyl-, (C3-C6)cycloalkyl or aryl; and each R2 is independently H, (C1-C6)alkyl, aryl(C1-C6)alkyl-, (C3-C6)cycloalkyl or aryl; or R1 and R2 together with the atom to which they are attached form a (C3-C7)cycloalkyl; wherein any alkyl or cycloalkyl of R1 or R2 may be optionally substituted with one or more groups selected from halo, (C1-C6)alkoxy and NRaRb and wherein any aryl of R1 or R2 may be optionally substituted with one or more groups selected from halo, (C1-C6)alkyl, (C1-C6)alkoxy, NRaRb, nitro and cyano;

Ra and Rb are each independently selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl and aryl; or Ra and Rb together with the nitrogen to which they are attached form a pyrrolidino, piperidino, piperazino, azetidino, morpholino, or
thiomorpholino;

n is 1, 2 or 3; and
each X is H;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,607,401

CONSTRAINED KEY FRAME LOCALIZATION AND MAPPING FOR VISION-AIDED INERTIAL NAVIGATION

Regents of the University...

1. A vision-aided inertial navigation system comprising:
an image source to produce image data for a first keyframe, one or more non-keyframes and a second keyframe along a trajectory
of the vision-aided inertial navigation system (VINS), the one or more non-keyframes located between the first keyframe and
second keyframe along the trajectory;

an inertial measurement unit (IMU) to produce IMU data indicative of a motion of the VINS along the trajectory for the keyframe
and the one or more non-keyframes; and

a processing unit comprising an estimator that processes the IMU data and the image data to compute respective state estimates
for a position and orientation of the VINS for the first keyframe and for the second keyframe,

wherein, when computing the state estimates, the estimator constrains the state estimates for the second keyframe relative
to the state estimates for the first keyframe based on the IMU data and the image data from the one or more non-keyframes,
and

wherein, when constraining the state estimates, the estimator treats a landmark observed within the image data for the first
keyframe or the second keyframe as different from the same landmark observed within the image data for the non-keyframes.

US Pat. No. 9,580,689

INDUCED PLURIPOTENT STEM CELLS

Regents of the University...

1. A method to increase efficiency of reprogramming cells to form induced pluripotent stem cells (iPSC) comprising a) introducing
i) a nucleic acid encoding a fusion protein comprising a transactivation domain from MyoD fused to the N-terminus or C-terminus
of Oct4 operably linked to a promoter, and ii) at least one nucleic acid encoding Sox2, Klf4, and optionally c-Myc operably
linked to a promoter into a somatic cell, wherein the somatic cell expresses the nucleic acids of i) and ii); and
b) culturing said somatic cell for a time to reprogram into a pluripotent stein cell, wherein the fusion protein increases
the efficiency of reprogramming the somatic cell into a iPSC.

US Pat. No. 9,576,593

AUTOMATED VERBAL FLUENCY ASSESSMENT

Regents of the University...

1. A method comprising:
obtaining, by a computing device via a speech analyzer, a waveform representing a digital recording of audio speech of a person,
the speech analyzer comprising at least one of a microphone, an interface to a sound recorder, an interface to a database,
or an interface to a data storage system;

measuring, by the computing device, amplitudes of waves within the waveform, the waves corresponding to samples of the digital
recording of the audio speech of the person;

classifying, by a silence detector of the computing device, the samples of the digital recording of the audio data of the
speech of the person, based on the measured amplitudes of the samples and on a silence threshold, into a first class of samples
including speech or sound and a second class of samples including silence, wherein classifying the samples comprises:

sorting, by the silence detector, the samples of the audio data in an order defined by the amplitudes of the samples of the
audio data;

determining, by the silence detector, the silence threshold based on the amplitudes of the samples of the audio data, wherein
determining the silence threshold comprises:

calculating, by the silence detector, linear regressions of the sorted samples in the sorted order; and
determining, by the silence detector, the silence threshold as the amplitude of one of the samples for which a slope of the
calculated linear regression exceeds a predetermined value;

classifying, by the silence detector, samples having amplitudes above the silence threshold as belonging to the first class;
and

classifying, by the silence detector, samples having amplitudes below the silence threshold as belonging to the second class;
analyzing, by the computing device, the first class of samples to determine a number of words spoken by the person;
calculating, by the computing device, a verbal fluency score for the person based at least in part on the determined number
of words spoken by the person, and

outputting, by the computing device, the verbal fluency score.

US Pat. No. 9,502,382

COPLANER WAVEGUIDE TRANSITION

Regents of the University...

16. A semiconductor device comprising:
a first semiconductor chip;
a second semiconductor chip; and
a coplanar waveguide transition electrically coupling the first semiconductor chip to the second semiconductor chip, the coplanar
waveguide transition comprising:

a substrate;
a first coplanar waveguide on a first side of the substrate, the first coplanar waveguide electrically coupled to the first
semiconductor chip;

a second coplanar waveguide on a second side of the substrate, the second coplanar waveguide electrically coupled to the second
semiconductor chip;

a first, a second, and a third via through the substrate electrically coupling the first coplanar waveguide to the second
coplanar waveguide; and

voids through the substrate between the first, second, and third vias and edges of the first coplanar waveguide and edges
of the second coplanar waveguide,

wherein the voids comprise:
a first void between the first via and the second via;
a second void between the second via and the third via;
a third void between the first via and an edge of the first coplanar waveguide and an edge of the second coplanar waveguide;
and

a fourth void between the third via and an edge of the first coplanar waveguide and an edge of the second coplanar waveguide.

US Pat. No. 9,878,002

COMPOSITIONS AND METHODS INVOLVING ENDOGENOUS RETROVIRUS PROTEINS

REGENTS OF THE UNIVERSITY...

1. A method of slowing cellular growth, the method comprising: overexpressing an endogenous HR1-HR2 superfamily retrovirus
envelope protein in at least one cell, wherein the cell expresses p53 and expression of the retrovirus envelope protein is
controlled by p53; and exposing the cell to conditions that upregulate expression of p53.
US Pat. No. 9,815,808

RECOVERY OF MONOMER FROM POLYURETHANE MATERIALS BY DEPOLYMERIZATION

REGENTS OF THE UNIVERSITY...

1. A method for recovering ?-methyl-?-valerolactone (MVL) from a polyurethane polymer comprising poly(?-methyl-?-valerolactone)
(PMVL) block, the method comprising:
heating the polymer to cause depolymerization and release of the MVL from the PMVL block; and
recovering the released MVL.

US Pat. No. 9,737,244

SENSOR HAVING FERROGEL WITH MAGNETIC PARTICLES

Purdue Research Foundatio...

1. A sensor for detecting a condition, the sensor comprising:
a container;
a hydrogel arranged within the container and configured to change thickness or volume in response to the condition;
a plurality of magnetic particles arranged in the hydrogel so that a magnetic property of the hydrogel changes with changes
of thickness or volume of the hydrogel; and

a device coil arranged within the container and arranged with respect to the hydrogel so that changes in the magnetic property
modulate an electrical property of the sensor, wherein terminals of the device coil are open.

US Pat. No. 9,714,997

LOCALIZATION OF MAGNETIC PARTICLES BY MEANS OF SWIFT-MRI

Regents of the University...

1. A system comprising:
a magnetic resonance scanner; and
a processor coupled to the scanner and configured to generate magnetic resonance (MR) image data, the MR image data including
complex data having a first component and a second component for a subject, the processor configured to generate a first image
using the first component and generate a second image using the second component, the MR image data acquired in a time-share
mode and substantially simultaneous with excitation, the excitation including a short T2 sensitive sequence provided by the scanner, and wherein the first image corresponds to anatomy of the subject and the second
image corresponds to a magnetic material within the subject, the first image different from the second image, and the processor
configured to identify a position of the magnetic material within the subject based on the second image.

US Pat. No. 9,649,620

PARTICULATE SORPTION MEDIUM PREPARED FROM PARTIALLY DECOMPOSED ORGANIC MATTER

American Peat Technology,...

1. A process for the production from partially decomposed organic matter of a sorption media for use in the treatment of aqueous
solutions to remove at least one type of aqueous contaminant, comprising the steps of:
(a) supplying an amount of the partially decomposed organic matter to a granulating machine;
(b) granulating the partially decomposed organic matter;
(c) drying the granules;
(d) thermally activating the granules without chemical activation using an activation heat medium at a temperature of about
175-287° C., wherein the granule has a Ball-Pan Hardness number of about 75%-100% and is suitable for sorption of the aqueous
contaminant found in the aqueous solution; and

(e) chemically treating the thermally-activated granule, comprising:
(i) treatment of the granule with an acid solution to dissolve out the mineral form of at least one type of media contaminant
naturally found in the partially decomposed organic matter starting material to place the mineral form of the media contaminant
into the acid solution and onto the active sorption sites in the granule followed by separation of the acid solution containing
the dissolved mineral form of the media contaminant from the granule;

(ii) followed by treatment of the resulting acid-treated granule with a salt solution to displace the media contaminant off
the active sorption sites in the granule and into the salt solution;

(f) wherein the thermally-activated and chemically-treated granules can sorb the aqueous contaminant from the aqueous solution
without introducing the media contaminant into the treated aqueous solution.

US Pat. No. 9,648,942

TOOTHBRUSH

Regents of the University...

1. A toothbrush comprising:
first and second flexible anchor portions extending along a longitudinal axis and away from the longitudinal axis in a first
direction that is perpendicular to the longitudinal axis;

a plurality of bristles coupled to said first and second flexible anchor portions;
a soft pivot bar longitudinally aligned with the longitudinal axis and operably coupled to said flexible anchor portions,
the soft pivot bar including a tooth-engaging portion that extends in the first direction and into a cavity formed between
the first and second flexible anchor portions, a cross-sectional shape of the tooth-engaging portion taken in a plane that
is perpendicular to the longitudinal axis tapers to a pointed end portion; and

a plurality of bristles extending from the tooth-engaging portion of the soft pivot bar;
wherein a chewing force applied to said pivot bar causes said pivot bar and said anchor portions to compress against a tooth
surface to cause a cleaning action.

US Pat. No. 9,551,687

HIGH MAGNETIC MOMENT PARTICLE DETECTION

Regents of the University...

1. A device comprising:
a sensor having a surface, the surface including a plurality of conductive layers interspersed by a plurality of intermediary
layers, a magnetization direction of a first subset of the plurality of conductive layers and a magnetization direction of
a second subset of the plurality of conductive layers having a ground state orientation of approximately 0 degrees, wherein
the first subset is exclusive of the second subset; and

a pair of electrodes coupled to the sensor surface and wherein an electrical resistance difference between the pair of electrodes
is determined by a magnetic field proximate the sensor surface and wherein the sensor surface has an aspect ratio, corresponding
to a length and a width of the sensor surface, that is sufficiently small such that a magnetic dipole field of a nanoparticle
proximate the sensor surface is detectable as an electrical resistance difference between the pair of electrodes.

US Pat. No. 9,493,948

SELF-SUPPORTING ROOF PANEL

Regents of the University...

1. A roof panel for a building, said roof panel being supported only at a side wall of the building and at a roof ridge of
the building, said roof panel comprising:
spaced apart first and second face sheets, each face sheet having a surface defined by spaced longitudinal edges and end edges;
a load carrying support web structure of strength to support the roof panel secured to the surfaces of the spaced apart face
sheets, said web structure providing strength to permit supporting the roof panel only at the side wall and the roof ridge
of the building without intervening supports;

an insulation layer secured on an exterior of either the first face sheet or the second face sheet, the insulation layer extending
to cover the entire surface of the first face sheet or the second face sheet and wherein the insulating layer is non-structural;
and

a longitudinally extending connector member along one longitudinal edge for joining a second self supporting roof panel longitudinal
edge, said connector member underlying the insulation layers of the joined self supporting roof panels, with no portion of
the support web structure and connector passing though the insulation layers.

US Pat. No. 9,464,902

SYMBIOTIC UNMANNED AERIAL VEHICLE AND UNMANNED SURFACE VEHICLE SYSTEM

Regents of the University...

1. A system comprising:
an unmanned aerial vehicle having a memory storing a plurality of collection points and at least one sensor for collecting
sensor data from each of the collection points;

an unmanned surface vehicle capable of moving to a plurality of locations, the unmanned surface vehicle comprises a memory
storing a plurality of soil measurement locations and a landing time and a landing location for the unmanned aerial vehicle
and at least one soil sensor and wherein the unmanned surface vehicle collects at least one soil measurement using the at
least one soil sensor at each of the soil measurement locations;

wherein the unmanned aerial vehicle travels through the air between at least two collection points stored in the memory and
wherein the unmanned aerial vehicle is carried between at least two collection points stored in the memory by the unmanned
surface vehicle.

US Pat. No. 9,411,033

METHODS AND APPARATUS FOR IMAGING WITH MAGNETIC INDUCTION

REGENTS OF THE UNIVERSITY...

1. An apparatus comprising:
a magnetic energy source configured to provide a static magnetic field oriented along a direction and a magnetic signal that
induces electrical currents in a sample, the magnetic signal being oriented along the same direction as the static magnetic
field;

a detector configured to detect an acoustic energy signal that is produced in response to forces generated by a combination
of the induced electrical currents and the static magnetic field; and

a computer to process the acoustic energy signal to:
determine an electrical impedance distribution of the sample;
produce an electrical impedance image that depicts the determined electrical impedance distribution of the sample;
display the electrical impedance image in a displaying device, in conjunction with other anatomic imaging results; and
identify cancer from impedance contrast in the electrical impedance distribution of the sample.
US Pat. No. 9,050,372

HIGH MOLECULAR WEIGHT DERIVATIVES OF VITAMIN K-DEPENDENT POLYPEPTIDES

Regents of the University...

1. An isolated or recombinant mutant Factor VII or Factor VIIa polypeptide linked to a polyethylene glycol (PEG) polymer,
wherein the polypeptide comprises a modified gamma-carboxyglutamic acid (GLA) domain having an amino acid sequence with two,
three, four, or five substitutions relative to the amino acid sequence of the wild-type human Factor VII or Factor VIIa GLA
domain, wherein the substitutions comprise P10Q and K32E, and wherein the circulation lifetime of the polypeptide linked to
PEG is increased as compared to a corresponding polypeptide not linked to PEG, and offsets any reduction in coagulation function
as compared to a corresponding polypeptide not linked to PEG.
US Pat. No. 9,981,067

BIOMIMETIC HYBRID GEL COMPOSITIONS AND METHODS OF USE

BIOACTIVE REGENERATIVE TH...

1. A hybrid gel composition comprising:dextran sulfate;
at least one polycationic macromolecule;
a solvating fluid;
embedded endocrine cells; and
embedded pluripotent cells;
wherein the dextran sulfate, at least one polycationic macromolecule, and solvating fluid form a three-dimensional hybrid gel composition comprising a network of insoluble, polyelectrolytic complexes, wherein the network of insoluble, polyelectrolytic complexes has regions of unreacted dextran sulfate and regions of unreacted polycationic macromolecules.

US Pat. No. 9,851,316

SYSTEM AND METHOD FOR DETERMINING A SPATIAL THERMAL PROPERTY PROFILE OF A SAMPLE

Regents of the University...

1. A sensing system for determining a thermal conductivity of a sample, the sensing system comprising:
a lossy electrical conductor configured to thermally contact the sample;
a driver configured to electrically power the lossy electrical conductor at a driving frequency, the electrically powered
lossy electrical conductor configured to carry a current therethrough, the current having a current value at the driving frequency;

an analyzer configured to measure a voltage across the lossy electrical conductor and extract from the measured voltage a
fundamental voltage value at the driving frequency and a third harmonic voltage value at a third order harmonic of the driving
frequency; and

a processor coupled to the driver and the analyzer and configured to determine the thermal conductivity of the sample based
on the current value, the fundamental voltage value, and the third harmonic voltage value.

US Pat. No. 9,796,993

LIGNIN-DEGRADING METHODS

REGENTS OF THE UNIVERSITY...

1. A method comprising:
contacting a lignin sample with an isolated flavin-dependent monooxygenase and forming at least partially degraded lignin;
and

contacting the lignin sample with an auxiliary compound that disrupts noncovalent interaction between the at least partially
degraded lignin and the flavin-dependent monooxygenase.

US Pat. No. 9,573,888

THERAPEUTIC COMPOUNDS

REGENTS OF THE UNIVERSITY...

1. The compound:

or a salt thereof.

US Pat. No. 9,568,572

BANDAGE OR GARMENT COMBINED WITH A WIRELESSLY COUPLED MAGNETIC RESONANCE COIL

Regents of the University...

1. A radio frequency magnetic resonance coil current element coupled to a bandage and a wireless communication circuit comprising:
at least one magnetic resonance coil current element configured as a volume coil or a surface coil configured for imaging
a specimen, a magnetic resonance coil current element including a first conductive element, a second conductive element, and
a dielectric element, the first conductive element and the second conductive element being separated by the dielectric element,
wherein the at least one current element is configured for transmitting, and/or receiving at least one radio frequency signal
to and/or from a region of interest of the specimen;

a wireless communication circuit coupled to the at least one current element, the wireless communication circuit configured
to provide a wireless communication link between the at least one current element and a computer system of a magnetic resonance
(MR) system that is configured for providing information pertaining to the at least one radio frequency signal, with the wireless
communication circuit displacing a volume of space distinct from volumes of space displaced by the first conductive element,
the second conductive element, and the dielectric element; and

a bandage coupled to the at least one magnetic resonance coil current element and the wireless communication circuit, wherein
the bandage includes an adhesive coated surface that permits removably affixing the at least one magnetic resonance coil current
element to a skin surface of a subject;

wherein the magnetic resonance coil is disposed proximal to a main magnet of the MR system and the computer system of the
MR system is disposed distal to the main magnet of the MR system.

US Pat. No. 9,499,800

METHODS OF MAKING AND USING CHEMICALLY SELF ASSEMBLED-NANORINGS

Regents of the University...

1. A compound of formula I:
wherein:
A is a divalent, branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 2 to 25 carbon atoms, wherein
one or more of the carbon atoms is optionally replaced by (—O—), and wherein the chain is optionally substituted on carbon
with one or more substituents selected from (C1-C6)alkoxy, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, azido, cyano, nitro, halo, hydroxy, oxo (?O), carboxy, aryl, aryloxy, heteroaryl, and heteroaryloxy;

B is a divalent, branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 2 to 25 carbon atoms, wherein
one or more of the carbon atoms is optionally replaced by (—O—), and wherein the chain is optionally substituted on carbon
with one or more substituents selected from (C1-C6)alkoxy, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, azido, cyano, nitro, halo, hydroxy, oxo (?O), carboxy, aryl, aryloxy, heteroaryl, and heteroaryloxy;

X is N or

Y is a divalent, branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 20 to 250 carbon atoms,
wherein one or more of the chain carbon atoms is optionally replaced by O, S, NRa, (C?O) or a 5 or 6-membered heterocycle, wherein each Ra is independently H or (C1-C6)alkyl, and wherein the chain is optionally substituted on carbon with one or more substituents selected from (C1-C6)alkoxy, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, azido, cyano, nitro, halo, hydroxy, oxo (?O), carboxy, aryl, aryloxy, heteroaryl and heteroaryloxy;

R1 is a branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 3 to 30 carbon atoms; and

R2 is a branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 3 to 30 carbon atoms;
or a salt thereof.

US Pat. No. 9,848,934

THERMOCHEMICAL ABLATION OF BODILY TISSUE

Regents of the University...

1. A thermochemical ablation system, comprising:
a percutaneous fluid delivery cannula comprising first and second lumens extending from a proximal portion to a distal portion,
the distal portion comprising a first exterior port along a distal exterior portion of the percutaneous fluid delivery cannula
and a second exterior port along the distal exterior portion of the percutaneous fluid delivery cannula, the first exterior
port being in fluid communication with the first lumen, and the second exterior port in fluid communication with the second
lumen;

first means for containing a first thermochemical ablation liquid and communicating the first thermochemical ablation liquid
through the first lumen to the first exterior port along the distal exterior portion of the percutaneous fluid delivery cannula;
and

second means for containing a second thermochemical ablation liquid and communicating the second thermochemical ablation liquid
through the second lumen to the second exterior port along the distal exterior portion of the percutaneous fluid delivery
cannula so that the second thermochemical ablation liquid is isolated from the first thermochemical ablation liquid before
exiting from the second exterior port of the percutaneous fluid delivery cannula, the second thermochemical ablation liquid
being reactive with the first thermochemical ablation liquid,

means for simultaneously delivering the first and second thermochemical ablation liquids out of the respective first and second
exterior ports along the distal exterior portion of the percutaneous fluid delivery cannula to provide simultaneous dispersion
and mixing of the first and second thermochemical ablation liquids proximate to the distal exterior portion, the second thermochemical
ablation liquid being reactive with the first thermochemical ablation liquid to generate tissue ablation heat via an exothermic
chemical reaction.

US Pat. No. 9,827,228

OPIOID RECEPTOR MODULATORS AND USE THEREOF

National Health Research ...

1. A pharmaceutical composition for treating an opioid receptor-associated condition, the pharmaceutical composition comprising
a pharmaceutically acceptable carrier, a mu-opioid receptor antagonist, and a compound of Formula (I):

wherein
U is H, C1-6 alkyl, C3-8 cycloalkyl, C2-8 heterocycloalkyl, C6-14 aryl, or C1-13 heteroaryl;

V is H, C1-6 alkyl, C3-8 cycloalkyl, C2-8 heterocycloalkyl, or C1-13 heteroaryl; and

Z is O or S,
in which
each of C1-6 alkyl, C3-8 cycloalkyl, C2-8 heterocycloalkyl, C6-14 aryl, and C1-13 heteroaryl, independently, is optionally mono-, di-, or tri-substituted with halo, OH, CN, NH2, NO2, COOH, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C3-8 cycloalkyl, C2-8 heterocycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylamino, C2-6 dialkylamino, C7-12 aralkyl, C1-12 heteroaralkyl, —C(O)OR, —C(O)NRR?, —NRC(O)R?, —S(O)2R, —S(O)2NRR?, —NRS(O)2R?, —C(O)R, or —NRS(O)2NR?R?; or is optionally fused with C3-8 cycloalkyl, C2-8 heterocycloalkyl, C6-14 aryl, or C1-13 heteroaryl; each of R, R?, and R?, independently, being H, halo, OH, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C3-8 cycloalkyl, C2-8 heterocycloalkyl, C6-14 aryl, or C1-13 heteroaryl.

US Pat. No. 9,745,586

THERAPEUTIC POLYNUCLEOTIDES, COMPOSITIONS, AND METHODS

REGENTS OF THE UNIVERSITY...

1. A method of treating cardiac disease, the method comprising:
administering to a subject a composition comprising:
an xNA molecule comprising at least six nucleotides, in an amount effective to increase the rate of myocyte relaxation, wherein
a dissociation constant of the xNA molecule with phospholamban is less than 260 nM; and

a pharmaceutically acceptable carrier.

US Pat. No. 9,766,074

VISION-AIDED INERTIAL NAVIGATION

Regents of the University...

1. A vision-aided inertial navigation system comprising:
at least one image source to produce image data for a plurality of poses of a frame of reference along a trajectory within
an environment over a period of time, wherein the image data includes features that were each observed within the environment
at poses of the frame of reference along the trajectory, wherein one or more of the features were each observed at multiple
ones of the poses of the frame of reference along the trajectory;

a motion sensor configured to provide motion data of the frame of reference in the environment for the period of time; and
a hardware-based processor communicatively coupled to the image source and communicatively coupled to the motion sensor, the
processor configured to compute estimates for at least a position and orientation of the frame of reference for each of the
plurality of poses of the frame of reference along the trajectory,

wherein the processor is configured to:
determine, from the image data, feature measurements corresponding to the features observed from the poses along the trajectory;
group the feature measurements according to the features observed within the image data;
for one or more of the features observed from multiple poses along the trajectory, compute based on the respective group of
feature measurements for the feature, one or more constraints that geometrically relate the multiple poses from which the
respective feature was observed; and

determine the position and orientation of the frame of reference for each of the plurality of poses along the trajectory by
updating, in accordance with the motion data and the one or more computed constraints, state information within a state vector
representing estimates for the position and orientation of the frame of reference along the trajectory while excluding, from
the state vector, state information representing estimates for positions within the environment for the features that were
each observed from the multiple poses and for which the one or more constraints were computed.

US Pat. No. 9,717,660

FLUORIDE RELEASING DENTAL COMPOSITION AND DENTAL APPLIANCE

Regents of the University...

1. A fluoride-releasing dental composition, comprising:
a polymeric compound chosen from butyl methacrylate, ethylene vinyl acetate, and mixtures and combinations thereof; and
about 50 wt% of a fluoride compound chosen from NaF, SnF, and mixtures and combinations thereof.

US Pat. No. 9,605,219

SOLAR GASIFIER

Regents of the University...

1. A solar gasifier comprising:
a first wall delineating a reaction chamber configured to hold a catalyst and a reactant, the reaction chamber being cylindrical
and extending along a longitudinal axis from a first end to a second end, the longitudinal axis horizontally disposed;

a reactant inlet port fluidly connected to the reaction chamber;
a product outlet port fluidly connected to the reaction chamber; and
a second wall located within the reaction chamber and delineating a heating chamber configured to receive light, the heating
chamber extending along the longitudinal axis from the first end to the second end, the second wall preventing the catalyst
and the reactant from entering the heating chamber, wherein at least a portion of the heating chamber is positioned within
the reaction chamber such that a heat flow from the heating chamber into a portion of the reaction chamber holding the catalyst
and the reactant results in an upward flow of the catalyst and the reactant proximate an exterior surface of the second wall
and in a downward flow of the catalyst and the reactant proximate an interior surface of the first wall.

US Pat. No. 9,592,196

METHODS AND COMPOSITIONS FOR APPLYING PHARMACOLOGIC AGENTS TO THE EAR

Regents of the University...

1. An aqueous composition comprising:
A suitable amount of a viscogenic agent such that the composition has a gelation temperature is greater than the ambient temperature
and less than or equal to the temperature of the tympanic membrane, wherein the composition is a liquid below the gelation
temperature and is a gel over the gelation temperature, and wherein the composition comprises 5% to 45% of the viscogenic
agent; a therapeutic amount of at least one pharmacologic agent; and a diluent; wherein the formulation is flowable and has
a viscosity less than 100,000 cps at 25° C.

US Pat. No. 9,541,615

SYSTEM AND METHOD FOR MULTI-ROI MRI IMAGING USING AN RF LOOP COIL

Regents of the University...

1. A method for producing a dental image of a subject with a magnetic resonance imaging (MRI) system, the steps comprising:
a) providing an intra-oral radio frequency (RF) coil, the intra-oral RF coil being a shape of a human dental arch;
b) positioning the intra-oral RF coil between an upper jaw and a lower jaw of the subject in an occlusal plane, wherein the
intra-oral RF coil extends along the occlusal plane and is orthogonal to a static magnetic field (B0) of the MRI system;

c) acquiring image data from the upper jaw and the lower jaw utilizing a transverse component of an excitation field (B1)
generated using the MRI system, the transverse component of the B1 field being parallel to the occlusal plane that the intra-oral
RF coil is positioned in; and

d) reconstructing an image of the upper jaw and the lower jaw from the image data.

US Pat. No. 9,534,236

MEMBRANES FOR WASTEWATER-GENERATED ENERGY AND GAS

Regents of the University...

1. An apparatus for producing a hydrogen gas from a wastewater fluid, comprising:
a membrane including:
a first layer of a first polymer;
immobilized acetogenic bacteria, wherein the immobilized acetogenic bacteria are immobilized within the first polymer and
configured to produce a hydrogen gas in a hydrogen production zone from one or more compounds in a wastewater fluid,

a second layer of a second polymer, the second layer adjacent the first layer;
a third layer of a third polymer, the third layer adjacent the first layer, the second layer and the third layer being substantially
abiotic, the second layer and the third layer configured to isolate the hydrogen production zone from the wastewater fluid;
and

a plurality of hollow fibers embedded within the first layer, the plurality of hollow fibers configured to convey the hydrogen
gas produced by the immobilized acetogenic bacteria away from the membrane.

US Pat. No. 9,980,503

CHEWING GUMS AND GUM BASES COMPRISING MULTI-BLOCK COPOLYMERS

Regents of the University...

1. A chewing gum composition comprising at least a flavoring agent, a sweetener and a chewing gum base comprising a multi-block copolymer having at least four homopolymeric blocks, each homopolymer block having at least three monomeric units, wherein the multi-block copolymer comprises a repeating sequence of at least two different homopolymeric blocks, wherein at least one of the homopolymeric blocks is a polyester selected from the group consisting of polyester homopolymers of lactic acid, D,L-lactide, D-lactide, L-lactide, and combinations thereof, and wherein there are at least two such sequences present in the multi-block copolymer.
US Pat. No. 9,943,826

POROUS SILICA HAVING HIGH PORE VOLUME AND METHODS OF MAKING AND USING SAME

REGENTS OF THE UNIVERSITY...

1. Hollow silica particles comprising an outer shell portion having a mesoporous structure, wherein the hollow silica particles have a pore volume of at least 4 cm3/g, wherein the pore volume is determined by nitrogen physisorption at partial pressures of P/Po of 0.99.

US Pat. No. 9,880,243

SIDEBAND PROCESSING FOR MAGNETIC RESONANCE

Regents of the University...

1. A method comprising:
applying a pulse train to a spin system in a scanner, the pulse train having a plurality of discontinuities in a time domain;
receiving a plurality of responses from the spin system, each response of the plurality of responses including baseband content
and sideband content;

generating a correction factor based on the baseband content and the sideband content, wherein generating the correction factor
includes processing a first response of the plurality of responses and processing a second response of the plurality of responses
wherein a gate position of a transmitter and a receiver for the first response is time shifted relative to the gate position
of the transmitter and receiver for the second response;

calculating a correction based on the correction factor; and
generating an image based on the correction.

US Pat. No. 9,823,316

MAGNETIC BIOMEDICAL SENSORS AND SENSING SYSTEM FOR HIGH-THROUGHPUT BIOMOLECULE TESTING

REGENTS OF THE UNIVERSITY...

1. A magnetic biosensing system comprising:
a probe array comprising a plurality of probes;
a magnetic biosensor array comprising:
a plurality of electrical contacts located along at least one peripheral edge of the magnetic biosensor array, wherein the
plurality of electrical contacts of the magnetic biosensor array are configured to receive respective ones of the plurality
of probes;

a sample container;
a plurality of magnetic biosensors each located adjacent to a surface of the sample container, each magnetic biosensor of
the plurality of magnetic biosensors comprising a magnetic sensor comprising a free layer and a fixed layer, wherein one of
the free layer or the fixed layer has a magnetic moment canted out of a major plane of the free layer or the fixed layer at
an inclined angle between 1 and 90 degrees, respectively, in an absence of an external magnetic field, and wherein the other
of the free layer or the fixed layer has a magnetic moment oriented parallel to the major plane of the free layer or the fixed
layer in the absence of the external magnetic field; and

a plurality of capture antibodies attached to the surface of the sample container;
a motor configured to move the probe array toward and away from the magnetic biosensor array to engage and disengage the plurality
of probes and the plurality of electrical contacts; and

a magnetic field generator located below the magnetic biosensor array to apply a magnetic field in a direction perpendicular
to a major plane of the magnetic biosensor array.

US Pat. No. 9,597,290

PARTICLE FUNCTIONALIZATION

Regents of the University...

1. A method of preparing polymer-functionalized particles, the method comprising:
(a) introducing a sputtering gas into a particle source under ultra-high vacuum conditions;
(b) ionizing the gas;
(c) passing the ionized gas through a plasma region in the opening(s) between targets or through the targets to liberate atoms
from the target, thereby yielding a gas comprising the liberated atoms;

(d) condensing the gas comprising the liberated atoms to yield particles;
(e) collecting the particles on a collection device that comprises a substrate and a polymeric functionalization coating disposed
on the substrate, wherein the particles impinge upon, and form bonds with molecules of the functionalization coating; and

(f) washing collected polymer-functionalized particles obtained in step (e), thereby removing the functionalized particles
coated with polymer molecules of the polymeric functionalization coating from the substrate.

US Pat. No. 9,585,579

SYSTEMS AND METHODS FOR NONINVASIVE SPECTRAL-SPATIOTEMPORAL IMAGING OF CARDIAC ELECTRICAL ACTIVITY

REGENTS OF THE UNIVERSITY...

1. A system for non-invasively generating a report of cardiac electrical activities of a subject, the system comprising:
a first input configured to receive anatomical information acquired from a region of interest in the subject including a heart
of the subject;

a second input configured to receive physiological information acquired from the subject related to the heart of the subject;
a non-transitory memory having stored thereon instructions;
a processor configured to access the memory to receive and execute the instructions and, following the instructions, to:
determine, using the physiological information, equivalent current densities (ECDs);
determine, using the ECDs, activation sequences (AS) and dominant frequency (DF) information for the heart of the subject;
and

generate a map of the heart of the subject using the anatomical information and the AS and DF information illustrating a spatial
distribution of electrical information over at least a portion of the heart of the subject.

US Pat. No. 9,556,412

INLET AND OUTLET GEOMETRIES FOR A VERTICAL THREE-STREAM MICROFLUIDIC DEVICE

Regents of the University...

1. A method of separating cells from a fluid sample under the influence of a force, comprising:
receiving a fluid through a centrally located top inlet of a plenum, the plenum having a diminishing volume in a direction
of the force with a first cross-sectional area proximate the inlet larger than a second cross-sectional area proximate a bottom
outlet of the plenum;

directing the fluid toward the bottom outlet disposed below the top inlet, the fluid directed against respective side-walls
of the plenum, the side walls each extending at an acute angle with respect to the direction of the force and positioned to
the side of the inlet and the bottom outlet; and

flowing the fluid in the plenum under the force, the plenum having a distance between each of two or more side outlets and
the bottom outlet, the distance selected such that cells in the fluid exit through the bottom outlet under the force while
a non-cell portion of the fluid exits through the two or more side outlets above the bottom outlet.

US Pat. No. 10,071,248

SYSTEMS AND METHODS FOR TUNING CLOSED-LOOP PHASIC BURST STIMULATION BASED ON A PHASE RESPONSE CURVE

Regents of the University...

1. A method for controlling a closed-loop stimulation system having one or more electrodes configured to apply stimulating electrical signals and to receive electrophysiological signals, the method comprising:a. measuring, with the one or more electrodes of the closed-loop stimulation system, electrophysiological signals from a subject;
b. estimating a phase response curve from the measured electrophysiological signals;
c. computing a slope of the phase response curve, wherein determining the electrical stimulation settings includes determining a phase window during which electrical stimulation is to be applied, wherein the phase window includes a range of phases during which the slope of the phase response curve has a positive slope;
d. determining electrical stimulation settings based on the computed slope of the phase response curve; and
e. controlling the closed-loop stimulation system to apply electrical stimulation based on the determined electrical stimulation settings.

US Pat. No. 9,861,464

CARDIO-EMBOLIC STROKE PREVENTION

Regents of the University...

1. An embolic protection device comprising:
an expandable and substantially cylindrical frame, wherein the frame is configured to expand to engage an inner wall of a
blood vessel, wherein the frame defines a longitudinal passageway through the frame when expanded, and wherein the expanded
frame includes an inner circumference; and

an embolus-deflection element within and coupled to the frame,
wherein the embolus-deflection element extends around a portion of the inner circumference of the frame less than the entire
inner circumference, and extends from the frame into the longitudinal passageway,

wherein the embolus-deflection element comprises a leading, embolus-deflection surface and a trailing surface,
wherein the leading, embolus-deflection surface and the trailing surface form a hydrofoil shape, and
wherein the embolus-deflection element is coupled to the frame such that the leading, embolus-deflection surface faces the
predominant flow of blood and is configured to deflect an embolus within the vessel when the embolic protection device is
implanted within the vessel.

US Pat. No. 9,721,767

EMBEDDED MASK PATTERNING PROCESS FOR FABRICATING MAGNETIC MEDIA AND OTHER STRUCTURES

Regents of the University...

1. A method comprising:
depositing a functional layer over a substrate;
depositing a granular layer over the functional layer, the granular layer including a first material defining a plurality
of grains separated by a second material defining grain boundaries of the plurality of grains, wherein the second material
defining the grain boundaries of the plurality of grains comprises at least one of a metal oxide or nitride;

removing the second material from the granular layer such that the plurality of grains of the granular layer define a hard
mask layer on the functional layer; and

removing portions of the functional layer not masked by the hard mask layer,
wherein the depositing of the functional layer, the depositing of the granular layer, removing the second material, and removing
the portions of the functional layer are performed in a vacuum environment.

US Pat. No. 9,709,649

SYSTEM AND METHOD FOR ASSESSING ADENOSINE TRIPHOSPHATE HYDROLYSIS RATE USING DOUBLE SATURATION TRANSFER MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY

Regents of the University...

1. A magnetic resonance imaging (MRI) system comprising:
a magnet system configured to generate a polarizing magnetic field about at least a region of interest (ROI) in a subject
arranged in the MRI system;

a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;
a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from a ROI;
a computer system programmed to:
control the plurality of gradient coils and the RF system according to a pulse sequence to acquire data including intrinsic
longitudinal relaxation time of phosphocreatine (PCr), T1,PCrint, acquired using an inversion recovery data acquisition with saturation of a gamma phosphate in adenosine triphosphate (ATP?);

control the plurality of gradient coils and the RF system according to a pulse sequence to acquire data including an intrinsic
longitudinal relaxation time of ATP?, T1,ATP?int, acquired using an inversion recovery data acquisition with both PCr and inorganic phosphate (Pi) saturation;

measure equilibrium magnetization of PCr (M0,PCr) and equilibrium magnetization of ATP? (M0,ATP?) using a relaxed control phosphorous-31 (P-31) spectrum acquired without saturation;

measure steady-state magnetization of PCr (Mss,PCr) using a P-31 spectrum acquired with ATP? saturation;

measure steady-state magnetization of ATP? (Mss,ATP?) using a P-31 spectrum acquired with both PCr and Pi saturation; and

calculate an ATP hydrolysis rate using the intrinsic longitudinal relaxation times of PCr and ATP?, the equilibrium magnetization
of PCr and ATP?, and the steady-state magnetization of PCr and ATP?.

US Pat. No. 9,700,085

PROTECTIVE GARMENTS AND METHODS OF MAKING

Regents of the University...

1. A protective garment comprising:
a body comprising a front portion, a rear portion and a neck opening;
a left sleeve attached to the body at a left sleeve opening and a right sleeve attached to the body at a right sleeve opening;
a left leg and a right leg each extending from the body;
a left shoulder region located between the left sleeve opening and the neck opening;
a right shoulder region located between the right sleeve opening and the neck opening;
a crotch region comprising a crotch point where the left and right legs meet the body, wherein a crotch axis extends horizontally
through the crotch point when the garment is worn by a person standing upright;

a first strap comprising a first strap upper portion and a first strap lower portion, and a second strap comprising a second
strap upper portion and a second strap lower portion, wherein the first strap and the second strap are each directly attached
to a material forming the rear portion of the body wherein at least a portion of the first strap comprises an elastic strap
that returns to at or near an original length after removal of an elongation force causing elastic elongation of the elastic
strap of 10% or more, and wherein the first strap is directly attached to the material forming the rear portion of the body
while the at least a portion of the first strap comprising the elastic strap is elastically elongated such that the material
forming the rear portion is shirred where directly attached to the first strap when the first strap is in a relaxed configuration;
and

a first strap line extending from the left shoulder region to the right leg on the rear portion of the body and a second strap
line extending from the right shoulder region to the left leg on the rear portion of the body, wherein the first strap line
and second strap line intersect at an intersection;

wherein the first strap upper portion is positioned coincident with the first strap line above the intersection, and the second
strap upper portion is positioned coincident with the second strap line above the intersection, and further wherein the first
strap lower portion is positioned coincident with one of the first strap line or the second strap line below the intersection,
and the second strap lower portion is positioned coincident with the other of the first strap line or the second strap line
below the intersection

wherein the body comprises a waist region located entirely below the left and right sleeve openings and entirely above the
crotch point, and wherein the intersection of the first strap line and the second strap line is located within the waist region.

US Pat. No. 9,700,601

COMPOSITIONS AND METHODS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS

Regents of The University...

1. A method for treating a lysosomal storage disorder comprising administering stem cells to a subject having a lysosomal
storage disorder, wherein the stem cells are isolated expanded human non-embryonic stem, non-germ cells, that express telomerase,
have undergone about 10-40 doublings in culture, and can differentiate into cell types of at least two of the endodermal,
ectodermal, and mesodermal lineages, and wherein the stem cells naturally express an amount of lysosomal enzyme effective
to treat said disorder, wherein the non-embryonic non-germ non-embryonic germ cells are derived from bone marrow.

US Pat. No. 9,670,199

ERGOLINE DERIVATIVES AS DOPAMINE RECEPTOR MODULATORS

REGENTS OF THE UNIVERSITY...

1. A compound of formula I:

wherein:
R1 is —C(?O)NRaRb;

R2 is (C1-C6)alkyl;

R3 is methyl;

R4 is H, halo, —C(?O)NRhRk, —C(?O)OK, (C1-C6)alkyl, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, or (C1-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, or (C1-C6)alkanoyloxy can optionally be substituted with one or more halo, hydroxy, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkanoyloxy, or NRmRn;

Ra is —C(?O)NRfRg;

Rb is (C1-C6)alkyl that is substituted with one or more NRfRg;

Rc is H, (C1-C6)alkyl, or aryl;

Rf and Rg are each independently H or (C1-C6)alkyl; or Rf and Rg together with the nitrogen to which they are attached form a heterocyclic ring;

Rh and Rk are each independently H, (C1-C6)alkyl or (C1-C6)alkanoyl, wherein any (C1-C6)alkyl or (C1-C6)alkanoyl can optionally be substituted with one or more NRfRg; or Rh and Rk together with the nitrogen to which they are attached form a heterocyclic ring; and

Rm and Rn are each independently H or (C1-C6)alkyl; or Rm and Rn together with the nitrogen to which they are attached form a heterocyclic ring;

or a salt thereof.

US Pat. No. 10,105,208

DECELLULARIZED BIOLOGICALLY-ENGINEERED TUBULAR GRAFTS

Regents of the University...

1. A method of making a decellularized, biologically-engineered, molded tubular graft, comprising:combining matrix-producing cells, fibrinogen and thrombin to produce a cell-seeded fibrin gel, wherein the matrix-producing cells are fibroblasts and are grown for between five passages and seven passages before being combined with the fibrinogen and thrombin;
molding the cell-seeded fibrin gel into a hollow tube;
circumferentially stretching or distending the hollow tube while providing or allowing for an axial length of the hollow tube to shorten in the presence of culture medium to result in a biologically-engineered, molded tubular graft comprising a cell-produced extracellular matrix; and
decellularizing the biologically-engineered, molded tubular graft to produce the decellularized, biologically-engineered, molded tubular graft, wherein the decellularized, biologically-engineered, molded tubular graft consists essentially of circumferentially aligned fibers and exhibits greater tensile stiffness in the circumferential direction than in the longitudinal direction and a burst pressure of at least 4000 mm Hg.

US Pat. No. 10,073,522

ARTICLES OF HANDWEAR FOR SENSING FORCES APPLIED TO MEDICAL DEVICES

REGENTS OF THE UNIVERSITY...

1. An article of handwear for grasping a medical device in a medical environment, the article of handwear comprising:a base adapted to be worn by a hand of a wearer;
a sensor assembly carried by the base, the sensor assembly adapted to sense a force applied by the hand of the wearer, via the article of handwear, to the medical device, and the sensor assembly adapted to send a signal comprising information regarding a total force of the force sensed by the sensor assembly and a first component of the force sensed by the sensor assembly; and
a processor in operable communication with the sensor assembly, the processor adapted to receive the signal and determine at least one shear component of the force sensed by the sensor assembly by using the first component and the total force.