US Pat. No. 9,382,349

POLYALPHAOLEFINS PREPARED USING MODIFIED SALAN CATALYST COMPOUNDS

ExxonMobil Chemical Paten...

1. A process comprising:
contacting one or more olefins with a catalyst system at a temperature, a pressure, and for a period of time sufficient to
produce a polyalphaolefin comprising at least 50 mol % C5 to C24 olefin;

the catalyst system comprising an activator and a catalyst compound according to Formula I, Formula II, Formula III, or a
combination thereof:

Formula I being represented by:

M is a Group 3, 4, 5 or 6 transition metal;
each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure, provided, however, where M is trivalent then X2 is not present;

each R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27 and R28 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or two
or more of R1 to R28 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof, or a combination thereof; and

Y is a divalent C1 to C20 hydrocarbyl;

Formula II being represented by:

where M is a Group 3, 4, 5 or 6 transition metal;
each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure, provided, however, where M is trivalent then X2 is not present;

each R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, and R21 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Group 13-17 of the periodic table of the elements, or two
or more of R1 to R21 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof; subject to the proviso that R19 is not a carbazole or a substituted carbazole radical, and

Y is a divalent C1 to C20 hydrocarbyl radical;

Formula III being represented by:

M is a Group 3, 4, 5 or 6 transition metal;
each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure, provided, however, where M is trivalent then X2 is not present;

R1 and R11 are C1-C10 hydrocarbyl radicals;

R4 and R14 are C1-C10 hydrocarbyl radicals or fluorine;

R6, R7, R8, R9, R10, R16, R17, R18, R19, and R20 are fluorine;

each R2, R3, R5, R12, R13, R15, R21, and R22 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Group 13-17 of the periodic table of the elements, or two
or more of R2, R3, R5, R12, R13, R15, R21, and R22 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof; and

Y is a divalent C1 to C20 hydrocarbyl radical.

US Pat. No. 9,464,148

VINYL TERMINATED POLYETHYLENE WITH LONG CHAIN BRANCHING

ExxonMobil Chemical Paten...

1. A polyolefin comprising:
a) at least 50% allylic vinyl chain ends;
b) an Mn of at least 200 g/mol, as determined by 1H NMR;

c) a ratio of long chain branching of at least 7 carbons per 1000 carbon atoms as determined by 13C NMR of greater than 0.5; and

d) at least 50 mole % ethylene.
US Pat. No. 9,556,287

VINYL TERMINATED MACROMONOMERS

ExxonMobil Chemical Paten...

1. A polyolefin, comprising:
i) at least 50 mole % ethylene;
ii) a ratio of saturated chain ends to allyl chain ends of greater than 1:1;
iii) a ratio of allylic vinyl groups per molecule as determined by 13C NMR of at least 50%;

iv) an Mw of 5,000 to 1,000,000 g/mol as determined by 1H NMR;

v) an allylic vinyl content of at least 50 mole %, based upon total number of moles of unsaturation, as determined by 1H NMR; and

vi) a ratio of long chain branching, of at least 7 carbons, of greater than 0.5 per 1000 carbon atoms, as determined according
to 13C NMR.

US Pat. No. 9,200,100

LONG-BRIDGED SALEN CATALYST

ExxonMobil Chemical Paten...

1. A catalyst compound represented by the formula:

comprising [O1,N1,N2]—[N1,N2,O2] in a fac-mer arrangement or a mer-fac arrangement or a fac-fac arrangement;

wherein each solid line represents a covalent bond and each dashed line represents a bond having varying degrees of covalency
and a varying degree of coordination;

wherein M is a Group 4, 5 or 6 transition metal;
wherein N1 and N2 are nitrogen and O1 and O2 are oxygen;

wherein each of X1 and X2 is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure;

wherein Y comprises an sp3 carbon directly bonded to N2 and is selected from the group consisting of divalent C1 to C40 hydrocarbyl radicals, divalent functional groups comprising elements from Groups 13-17 of the periodic table of the elements,
and combinations thereof;

wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Group 13-17 of the periodic table of the elements, or two
or more of R1 to R12 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure.

US Pat. No. 9,290,589

CYCLOPENTADIENYL-SUBSTITUTED SALAN CATALYSTS

ExxonMobil Chemical Paten...

1. A catalyst compound represented by the formula:

wherein each solid line represents a covalent bond and each arrow represents a bond having a varying degree of covalency and
a varying degree of coordination;

wherein M is a Group 3, 4, 5 or 6 transition metal;
N1 and N2 are nitrogen;

O is oxygen;
each of X1 and X2 is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13 to 17 of the periodic table of the elements, or
X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure, provided however when M is trivalent X2 is not present;

wherein each of R*1 and R*2 independently comprises a bulky functional group, an electron withdrawing group, or a combination thereof, and wherein at
least one of R*1 and R*2 independently comprises a cyclopentadienyl radical having the structure:


wherein C* indicates an attachment carbon of the radical;
each R1, R2, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, R14, R15, R16, and R17 is, independently, hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Groups 13 to 17 of the periodic table of the elements, two
or more of R1, R2, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, R14, R15, R16, and R17 independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof;

R7 is a C1-C40 hydrocarbyl radical or a functional group comprising elements from Groups 13 to 17 of the periodic table of the elements;
and

Y is a divalent C1 to C20 hydrocarbyl radical.

US Pat. No. 9,045,568

VINYL TERMINATED POLYETHYLENE WITH LONG CHAIN BRANCHING

ExxonMobil Chemical Paten...

1. A process comprising:
contacting one or more olefins with a catalyst system at a temperature, a pressure, and for a period of time sufficient to
produce a polyolefin comprising

a) at least 50% allyl chain ends; and
b) an Mn of at least 200 g/mol, as determined by 1H NMR;

the catalyst system comprising an activator and a catalyst compound according to Formula I, Formula II, or a combination thereof:
Formula I being represented by:

wherein M is a Group 4, 5 or 6 transition metal;
each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure;

each R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, and R28 is independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or two
or more of R1 to R28 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof, or a combination thereof; and

Y is a divalent C1 to C20 hydrocarbyl;

Formula II being represented by:

wherein M is a Group 4, 5 or 6 transition metal;
each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure;

each R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, and R21 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Group 13-17 of the periodic table of the elements, or two
or more of R1 to R21 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof; subject to the proviso that R19 is not a carbazole or a substituted carbazole radical, and Y is a divalent C1 to C20 hydrocarbyl radical.

US Pat. No. 9,193,813

PHENYLENE-BRIDGED SALALEN CATALYSTS

ExxonMobil Chemical Paten...

1. A catalyst compound represented by the formula:

wherein each solid line represents a covalent bond and each arrow represents a bond having a varying degree of covalency and
a varying degree of coordination;

wherein M is a Group 4 metal;
N1 and N2 are nitrogen;

O is oxygen;
each of X1 and X2 is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13 to 17 of the periodic table of the elements, or
X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure;

wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is, independently, hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Groups 13 to 17 of the periodic table of the elements, two
or more of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof.

US Pat. No. 9,200,099

SALENOL CATALYST

ExxonMobil Chemical Paten...

1. A catalyst compound represented by the formula:

wherein each solid line represents a covalent bond and each dashed line represents a bond having varying degrees of covalency
and a varying degree of coordination;

wherein M is a Group 3, 4, 5 or 6 transition metal;
wherein N1 and N2 are nitrogen and O1 and O2 are oxygen;

wherein n is 1 or 2;
wherein each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or where
n is 2 each X may join together to form a C4 to C62 cyclic or polycyclic ring structure;

wherein Y is selected from the group consisting of divalent C1 to C20 hydrocarbyl radicals, divalent functional groups comprising elements from Groups 13-17 of the periodic table of the elements,
and combinations thereof; and

wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Group 13-17 of the periodic table of the elements, or two
or more of R1 to R10 and Y may independently join together to form a C4 to C62 cyclic or polycyclic ring structure.

US Pat. No. 9,718,859

GLYCOGEN SYNTHASE KINASE-3 INHIBITORS

Ramot at Tel-Aviv Univers...

13. A method of inhibiting an activity of GSK-3, the method comprising contacting cells expressing GSK-3 with an effective
amount of a peptide, being of no more than 15 amino acid residues, and having an amino acid sequence which comprises a ZX1X2X3Z(p) recognition motif of a native GSK-3 substrate, wherein Z(p) is a phosphorylated serine residue or a phosphorylated threonine
residue; Z is a serine residue or a threonine residue, and each of X1, X2 and X3 is any amino acid,
the peptide having an amino acid sequence upstream said Z in which at least one polar or charged amino acid residue in an
amino acid sequence upstream said serine or threonine residue of said native GSK-3 substrate is replaced by at least one amino
acid residue selected from the group consisting of a non-polar amino acid residue, a non-charged amino acid residue (at a
physiological pH) and a hydrophobic amino acid residue,

the peptide exhibiting an inhibition activity towards GSK-3, such that when a GSK-3 reacts with a GSK-3 substrate in the presence
of the peptide, an apparent Michaelis Constant (app Km value) of the GSK-3 substrate is higher than a Michaelis Constant (Km
value) obtained in a similar assay in the absence of the peptide inhibitor.

US Pat. No. 10,115,584

COMPOSITION AND METHOD FOR FORMING A DIELECTRIC LAYER

Ramot at Tel-Aviv Univers...

1. A method of forming a porous layer, comprising:disassembling peptide supramolecular structures into discrete peptide nanospheres;
coating a substrate with a composition comprising a sol-gel precursor and a mixture of said discrete nanospheres in a medium that at least partially prevents assembly of said nanosphreres into supramolecular or colloidal structures, wherein a variance in a size of said nanosphreres is less than 2 nm2;
drying said composition; and
treating said dried composition so as to decompose said nanospheres, thereby forming voids in said dried composition.

US Pat. No. 9,102,595

COMPOUNDS SUITED AS NANOCARRIERS FOR ACTIVE AGENTS AND THEIR USE

Ramot at Tel-Aviv Univers...

1. A compound suited as an entity carrier, having the general formula (I)

with
PG denoting a linear or branched polyglycerol core,
X being
and being covalently bound to a carbon atom of the polyglycerol core, wherein the polyglycerol core carries a plurality of
groups of X, such that at least 50% of the free hydroxyl groups of the polyglycerol core are substituted by groups of X,
R1 being a methyl residue, and

R2? being an N-dimethyl ethyl amine residue.

US Pat. No. 9,688,719

GLYCOGEN SYNTHASE KINASE-3 INHIBITORS

Ramot at Tel-Aviv Univers...

1. A polypeptide consisting of the amino acid sequence of the formula
[Yn . . . Y1]ZX1X2X3S(p)W1F
wherein the polypeptide consists of 10 to 13 amino acid residues and optionally comprises a hydrophobic moiety attached thereto;wherein,
n is an integer from 3 to 6;
S(p) is a phosphorylated serine residue or a phosphorylated threonine residue;
Z is any amino acid residue except serine residue or threonine residue; and
X1-X3, Yn-Y1 and W1 are each independently any amino acid residue, wherein at least one of X1 and X2 is proline.

US Pat. No. 9,334,272

DERIVATIVES OF PURINIC AND PYRIMIDINIC ANTIVIRAL AGENTS AND USE THEREOF AS POTENT ANTICANCER AGENTS

Ramot at Tel-Aviv Univers...

1. A compound having Formula I:

wherein:
R1 is H;

R2 is an acyl moiety selected from the group consisting of valproyl, 4-phenylbutyryl, cinnamoyl, 2-(4-isobutylphenyl)propionyl,
1-(butyryloxymethoxy)succinyl, 1-(valproyloxymethoxy)succinyl, 1-(4-phenylbutyryloxymethoxy)succinyl, 1-(cinnamoyloxymethoxy)succinyl,
1-(phenylacetoxymethoxy)succinyl and 1-(2-(4-isobutylphenyl)propionyloxymethoxy)succinyl; and

R3 and R4 are each independently hydrogen or an acyl moiety selected from the group consisting of valproyl, 4-phenylbutyryl, cinnamoyl,
2-(4-isobutylphenyl)propionyl, 1-(butyryloxymethoxy)succinyl, 1-(valproyloxymethoxy)succinyl, 1-(4-phenylbutyryloxymethoxy)succinyl,
1-(cinnamoyloxymethoxy)succinyl, 1-(phenylacetoxymethoxy)succinyl and 1-(2-(4-isobutylphenyl)propionyloxymethoxy)succinyl.

US Pat. No. 9,991,458

NANOSHELL, METHOD OF FABRICATING SAME AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. A method of fabricating a nanoshell, comprising coating a nanometric core made of a first material by a second material, to form a core-shell nanostructure and applying non-chemical treatment to said core-shell nanostructure so as to at least partially remove said nanometric core, thereby fabricating a nanoshell, wherein said first material is a synthesized biological material and said second material comprises metal.

US Pat. No. 9,092,878

METHOD AND SYSTEM FOR PROCESSING AN IMAGE

Ramot at Tel-Aviv Univers...

1. A method of processing an image having a plurality of picture-elements, comprising:
preprocessing the image to selectively enhance contrast of some picture-elements of the image using a mapping function for
diminishing image data with intensity levels below an intensity threshold, thereby providing a preprocessed image, said mapping
function having a plateau region for intensity levels below said intensity threshold, and increasing monotonically for any
intensity level of said image above said intensity threshold;

employing a companding procedure for said preprocessed image, thereby providing a processed image; and
outputting said processed image to a computer readable medium or a display device.

US Pat. No. 9,365,661

POLYALPHAOLEFINS PREPARED USING MODIFIED SALAN CATALYST COMPOUNDS

ExxonMobil Chemical Paten...

1. A process comprising:
contacting one or more olefins with a catalyst system at a temperature, a pressure, and for a period of time sufficient to
produce a polyalphaolefin comprising at least 50 mol % C5 to C24 olefin;

the catalyst system comprising an activator and a catalyst compound according to Formula I, Formula II, Formula III, or a
combination thereof:

Formula I being represented by:

M is a Group 4, 5 or 6 transition metal;
each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure;

each R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, and R28 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or two
or more of R1 to R28 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof, or a combination thereof; and

Y is a divalent C1 to C20 hydrocarbyl;

Formula II being represented by:

where M is a Group 4, 5 or 6 transition metal;
each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure;

each R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, and R21 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Group 13-17 of the periodic table of the elements, or two
or more of R1 to R21 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof; subject to the proviso that R19 is not a carbazole or a substituted carbazole radical, and

Y is a divalent C1 to C20 hydrocarbyl radical;

Formula III being represented by

M is a Group 4, 5 or 6 transition metal;
each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or X1 and X2 join together to form a C4 to C62 cyclic or polycyclic ring structure;

R1 and R11 are C1-C10 hydrocarbyl radicals;

R4 and R14 are C1-C10 hydrocarbyl radicals or fluorine;

R6, R7, R8, R9, R10, R16, R17, R18, R19, and R20 are fluorine;

each R2, R3, R5, R12, R13, R15, R21, and R22 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Group 13-17 of the periodic table of the elements, or two
or more of R2, R3, R5, R12, R13, R15, R21, and R22 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure, or a combination thereof; and

Y is a divalent C1 to C20 hydrocarbyl radical.

US Pat. No. 9,150,676

THIO-SALALEN CATALYST

ExxonMobil Chemical Paten...

1. A catalyst compound represented by the formula:

wherein each solid line represents a covalent bond and each dashed line represents a bond having varying degrees of covalency
and a varying degree of coordination;

wherein M is a Group 3, 4, 5 or 6 transition metal;
wherein n is 1 or 2;
wherein each X is, independently, a univalent C1 to C20 hydrocarbyl radical, a functional group comprising elements from Groups 13-17 of the periodic table of the elements, or where
n is 2 each X may join together to form a C4 to C62 cyclic or polycyclic ring structure;

wherein Y is selected from the group consisting of divalent C3 to C20 hydrocarbyl radicals, divalent functional groups comprising elements from Groups 13-17 of the periodic table of the elements,
and combinations thereof; and

wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 is, independently, a hydrogen, a C1-C40 hydrocarbyl radical, a functional group comprising elements from Group 13-17 of the periodic table of the elements, or two
or more of R1 to R11 may independently join together to form a C4 to C62 cyclic or polycyclic ring structure.

US Pat. No. 9,474,787

MESENCHYMAL STEM CELLS FOR THE TREATMENT OF CNS DISEASES

Ramot at Tel-Aviv Univers...

1. An isolated non-genetically modified human cell differentiated ex vivo from a mesenchymal stem cell under conditions such
that the isolated non-genetically modified human cell expresses at least one mesenchymal stem cell marker and secretes brain-derived
neurotrophic factor (BDNF) and glial derived neurotrophic factor (GDNF), and does not secrete nerve growth factor (bNGF),
wherein said at least one mesenchymal stem cell marker is selected from the group consisting of CD73, CD90 and CD105, wherein
a basal secretion of said GDNF is at least two times greater than a basal secretion of said GDNF in a non-differentiated,
non-genetically modified human mesenchymal stem cell.
US Pat. No. 9,278,947

SEROTONIN REUPTAKE INHIBITORS AS DRUGS HAVING PERIPHERAL-SYSTEM-RESTRICTED ACTIVITY

Ramot at Tel-Aviv Univers...

1. A method of treating a disease or disorder in which reducing or preventing platelet aggregation and/or platelet-endothelial
interactions is beneficial, the method comprising administering to a subject in need thereof a therapeutically effective amount
of a serotonin reuptake inhibitor (SRI) compound which comprises citalopram modified so as to comprise at least one positively
charged group, said at least one positively charged group being a quaternary ammonium group, wherein said quaternary ammonium
group has the formula:
—(NR1R2R3)+Z?
wherein:
Z is an organic or inorganic anion;
R1 and R2 are each methyl; and

R3 is alkyl having from 1 to 4 carbon atoms.

US Pat. No. 9,118,518

TRANSMISSION SYSTEM WITH ISI CHANNEL AND METHOD OF OPERATING THEREOF

RAMOT AT TEL-AVIV UNIVERS...

1. A method of operating a communication system, the method comprising:
dividing a data sequence to be transmitted into a plurality of data blocks;
encoding one or more data blocks with one or more linear systematic cyclic codes thus giving rise to encoded data blocks;
transmitting said encoded data blocks over an ISI transmission channel;
upon receiving, applying a linear integer-forcing (IF) equalization to the received data blocks, wherein applying the linear
IF equalization comprises equalizing a channel response to impulse response followed by integer-valued filtering;

processing the output of the IF equalization thereby detecting for each encoded data block a valid codeword with maximal likelihood
of decoding, wherein the valid codeword is a result of cyclic convolution of a respective transmitted codeword with a filter
with integer-valued coefficients; and

reconstructing the data blocks using the respective detected valid codewords.

US Pat. No. 9,058,736

SYSTEM FOR AUTOMATIC FALL DETECTION FOR ELDERLY PEOPLE

Ramot at Tel-Aviv Univers...

1. Apparatus for detection of human falls, comprising:
an acceleration detector, for detecting vibration events, the acceleration detector attached to a floor, and configured to
sense low amplitude vibrations with accelerations up to 2 g;

a microphone, for placing in association with said acceleration detector for detection of sound events, and
a classification unit comprising an acceleration input for input of data relating to said vibration events from said acceleration
detector and a sound input for input of data relating to said sound events from said microphone, the unit configured to classify
separate events from said microphone and said acceleration detector respectively as concurrent events from said microphone
and said acceleration detector, thereby to determine whether a human fall is indicated, wherein said microphone has a frequency
range of substantially 20-16000 and an S/N ratio in excess of 58 dB.

US Pat. No. 9,122,955

METHOD AND SYSTEM OF CLASSIFYING MEDICAL IMAGES

Ramot at Tel-Aviv Univers...

1. A method of generating a category model for classifying medical images, comprising:
providing a plurality of anatomical medical images imaging at least one internal organ or area of a body;
in each of said plurality of anatomical medical images identifying a plurality of image patches, each image patch is represented
by a plurality of repeatable multidimensional features in a pixel area of a respective anatomical medical image and image
coordinates of said pixel area in said respective anatomical medical image, wherein said plurality of repeatable multidimensional
features of each of the plurality of image patches comprises at least one noise reduction based coefficient and a gray level
feature of the image patch;

for each of said image patches, weighting at least some of the noise reduction based coefficient, the gray level feature,
and the image coordinates, wherein said weighting is tuned experimentally on a cross-validation set;

generating a plurality of visual words by clustering said plurality of image patches represented by said weighted at least
one noise reduction based coefficient, gray level feature, and image coordinates of each one of said plurality of image patches;

modeling a category model mapping a relation between said plurality of visual words;
outputting said category model adapted to categorize a pathology in a new anatomical medical image based on a new set of image
patches from said new anatomical medical image and the coordinates of pixel areas of said new set of image patches in said
new anatomical medical image,

wherein at least one of said providing, generating, modeling, and outputting is performed by at least one processor.

US Pat. No. 9,402,565

METHOD AND SYSTEM FOR ANALYZING CRANIOFACIAL COMPLEX IMAGES

Mor Research Applications...

1. A method of analysis, comprising:
registering a target image to define a plurality of keypoints arranged in sets corresponding to polygons or linear segments
in the target image, said registering comprising ordering keypoints of at least one set, according to descriptor vectors associated
with said keypoints in said at least one set, so as to reduce an overall number of said sets, said ordering being by an ordering
operator calculated by applying to said database a procedure for detecting keypoints together with associated information
to provide a group of features, and projecting said descriptor vectors onto a first principal component of said group of features;

accessing a database of registered and annotated images, and employing a polygon-wise comparison between the target image
and each database image; and

using said comparison for projecting annotated locations from said database images into the target image.

US Pat. No. 9,153,022

METHOD AND SYSTEM FOR ANALYZING CRANIOFACIAL COMPLEX IMAGES

Mor Research Applications...

1. A method of analysis, comprising:
registering a target image to define a plurality of keypoints arranged in sets corresponding to polygons or linear segments
in the target image;

accessing a database of registered and annotated images, and employing a polygon-wise comparison between the target image
and each database image; and

using said comparison for projecting annotated locations from said database images into the target image;
wherein the target image is an image of a craniofacial complex of a subject, wherein said annotated locations correspond to
cephalometric landmarks and wherein the method further comprises extracting cephalometric features from the target image based
on said annotated locations and calculating characteristic pharyngeal airflow resistance, based, at least in part, on said
cephalometric features.

US Pat. No. 9,566,346

POSITIVELY CHARGED POLYSACCHARIDES FOR RNA TRANSFECTION

B.G. NEGEV TECHNOLOGIES A...

1. A complex for the delivery of a siRNA or miRNA, comprising the siRNA or miRNA complexed with a quaternized polysaccharide,
said polysaccharide being selected from the group consisting of starch, amylose, amylopectin, galactan and dextrin.
US Pat. No. 9,057,088

BIOLOGICALLY ACTIVE SILVER-COATED PROTEINS

Ramot at Tel-Aviv Univers...

1. A composition-of-matter comprising a protein having a solvent-accessible surface and further having a biological activity
and a metallic silver coating deposited over said surface and forming a silver-coated protein retaining said biological activity,
wherein said protein has at least one oxidized reducing moiety attached to at least a portion of said surface, said reducing
moiety being selected from the group consisting of hydrazine, hydrazide and imine, said oxidized reducing moiety being obtained
upon reducing silver ions to form said metallic silver coating, said silver coating is in a form of a continuous metallic
silver layer covering 0.1% to 60% of said surface, and wherein said protein is a hydrogen peroxide producing enzyme and said
biological activity is a catalytic reaction activity.
US Pat. No. 9,257,238

ELECTRODE AND METHOD OF MANUFACTURING THE SAME

Ramot at Tel-Aviv Univers...

1. An electroactive device, comprising a solid structure coated by at least one coating layer of peptide material forming
discrete peptide nanocrystals, wherein at least 70% of said peptide material in said at least one coating layer is devoid
of any non-covalent bonds.
US Pat. No. 9,221,779

SEROTONIN REUPTAKE INHIBITORS AS DRUGS HAVING PERIPHERAL-SYSTEM-RESTRICTED ACTIVITY

Ramot at Tel-Aviv Univers...

1. A serotonin reuptake inhibitor (SRI) compound comprising citalopram being modified so as to comprise at least one positively
charged group, said at least one positively charged group being a quaternary ammonium group, wherein said quaternary ammonium
group has the formula:
—(NR1R2R3)+Z?
wherein:
Z is an organic or inorganic anion;
R1 and R2 are each methyl; and

R3 is alkyl having from 1 to 4 carbon atoms.

US Pat. No. 9,155,828

APPARATUS AND METHODS FOR ENZYMATIC DEBRIDEMENT OF SKIN LESIONS

Ramot at Tel-Aviv Univers...

1. An apparatus for treating a skin lesion, said apparatus comprising:
(a) an applicator that comprises:
(i) a housing unit having a skin-facing opening and having an inlet tube having a plurality of openings and an outlet tube,
each providing a passageway for streaming of a solution therethrough and over a skin portion defined by said skin-facing opening;

(ii) means for affixing said applicator to the skin around the circumference of the skin lesion configured to maintain positive
or negative pressure at the site of the skin lesion; and

(iii) a separator being in fluid communication with said inlet tube and with a connector connecting to at least one reservoir,
to thereby reversibly disconnect and reconnect said inlet tube from said connector,

the applicator being configured for providing a continuous flow of a therapeutic solution into a wound bed of the skin lesion
effected by gravitation; and

(b) a spacer for occluding an area comprising the skin lesion, the spacer having a lower plane facing the skin, an upper plane
facing said housing, wherein the lower plane comprises adhesive means for affixing the spacer to the skin at the circumference
of said skin lesion.

US Pat. No. 9,284,274

CHEMICAL DERIVATIVES OF JASMONATE, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

RAMOT at Tel-Aviv Univers...

1. A compound represented by the structure of Formula II:

wherein
A is COR1;

R1 is an unsubstituted or substituted heteroaryloxy;

R2 is oxo;

R3, R4, R5, R6 and R7 are each hydrogen,

wherein the bond between C9 and C10 can be a single or double bond;

R15 and R16 are each hydrogen; and

n is selected from 0, 1 and 2;
including salts, hydrates, solvates, polymorphs, optical isomers, geometrical isomers, enantiomers, diastereomers, and mixtures
thereof.

US Pat. No. 9,494,665

MAGNETIC RESONANCE ANALYSIS USING A PLURALITY OF PAIRS OF BIPOLAR GRADIENT PULSES

Ramot at Tel-Aviv Univers...

1. A method of magnetic resonance analysis of a sample, comprising:
applying to the sample a plurality of pairs of bipolar gradient pulse subsequences,
wherein each bipolar gradient pulse subsequence of each pair comprises:
a first gradient pulse corresponding to a first activation of a gradient coil at a first amplitude for a first period of time,
a second gradient pulse corresponding to a second activation of said gradient coil at a second amplitude for a second period
of time, and

a radiofrequency sequence in which both said first gradient pulse and said second gradient pulse are embedded,
wherein said first and said second activations are along a gradient direction specific to said pair,
wherein said first and second amplitudes are of opposite polarity, and
wherein, in each pair, there is at least one radiofrequency pulse between every two successive gradient pulses;
acquiring a magnetic resonance signal from the sample;
analyzing the signal; and
issuing a report regarding said analysis.

US Pat. No. 9,203,425

LINEARIZED OPTICAL DIGITAL-TO-ANALOG MODULATOR

Ramot at Tel-Aviv Univers...

1. A circuit for converting a digital input data word having a plurality of bits into a modulated signal, comprising:
(a) an electrically controllable device, having a plurality of actuating electrodes, and operatively connected to an optical
output port, the electrically controllable device providing at the output port an optical signal that is modulated in response
to a binary actuation vector having a plurality of binary electrode-actuation voltages applied as electrode-actuation voltages
to the actuating electrodes;

wherein a number of said actuating electrodes is larger than a number of bits in the digital input data word; and
(b) an electrode actuating device having an electronic input for receiving the digital input data word and a digital-to-digital
converter, said electrode actuating device respectively supplying the plurality of binary electrode-actuation voltages to
the plurality of actuating electrodes;

wherein the digital-to-digital converter is enabled for presenting said binary actuation vector to the plurality of actuating
electrodes of the electrically controllable device to represent digital input data word.

US Pat. No. 9,365,828

GENETICALLY MODIFIED MUSCLE CELLS WHICH EXPRESS NEUROTROPHIC FACTORS

Ramot at Tel-Aviv Univers...

1. A method of treating Amyotrophic Lateral Sclerosis (ALS), comprising intramuscularly administering to a subject in need
thereof a therapeutically effective amount of the isolated cell population which comprises at least four subpopulations of
muscle progenitor cells, each of the at least four subpopulations being distinct in that they are genetically modified to
express a different neurotrophic factor, wherein the neurotrophic factor is selected from the group consisting of glial derived
neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic
factor (BDNF), thereby treating ALS.
US Pat. No. 9,364,511

ANTIVIRAL PREPARATIONS OBTAINED FROM A NATURAL CINNAMON EXTRACT

RAMOT AT TEL-AVIV UNIVERS...

1. A composition which is (1) an aqueous extract of cinnamon bark (Cinnamon sp.), (2) a precipitate of said aqueous extract or (3) a fraction of said extract or precipitate; said extract, precipitate
or fraction comprising an active fraction, said active fraction having an absorbance at 280 nm of between 15 and 20 OD, and
comprising at least one substance having a molecular weight greater than 10 kDa and antiviral activity.

US Pat. No. 9,682,098

COMPOUNDS SUITED AS NANOCARRIERS FOR ACTIVE AGENTS AND THEIR USE

Ramot at Tel-Aviv Univers...

1. A compound consisting of a linear or branched polyglycerol, wherein at least 50% of the free hydroxyl groups of the polyglycerol
core are substituted by an amine-containing group, said amine-containing group having a general formula selected from the
group consisting of:

wherein:
R1 and R2 are each independently selected from the group consisting of hydrogen, R3, and a linear or branched C1-C10-alkyl, which may be substituted and/or interrupted by one or more oxygen, sulphur and/or nitrogen atoms, provided that at
least one of R1 and R2 is not hydrogen;

R3 is selected from the group consisting of 4-aminobutyl, 4-(3-aminopropylamino)butyl, 3-(4-aminobutylamino)propyl, 3-(3-aminopropylamino)propyl,
3-(4-(3-aminopropylamino)butylamino)propyl, and


R4 is selected from the group consisting of hydrogen and a C1-C4-alkyl, which may be substituted and/or interrupted by one or more oxygen, sulphur and/or nitrogen atoms; and

n is an integer in a range of from 1 to 100.
US Pat. No. 9,446,226

DRUG-DELIVERING COMPOSITE STRUCTURES

Ramot at Tel-Aviv Univers...

1. A composite structure comprising a fibril core and a polymeric porous coat coating at least a part of said fibril core,
said fibril core being a fiber characterized by a tensile strength of at least 200 MPa, said coat comprising at least one
hydrophilic, amphiphilic or amphipathic bioactive agent encapsulated therein and/or applied thereon, wherein:
said coat has a microstructure of a freeze-dried water-in-oil emulsion, said emulsion comprises, prior to freeze-drying, a
dispersed aqueous solution and a continuous organic solution, said organic solution containing at least one second polymer
and said aqueous solution containing said at least one bioactive agent, and a ratio of said organic solution and said aqueous
solution is at least 8:1 and/or a concentration of said at least one second polymer ranges from 10 weight-to-volume percentages
to 25 weight-to-volume percentages; and wherein a plurality of droplets of said dispersed aqueous solution freeze-dry to form
microscopic capsules encapsulating said bioactive agent in a solid form of said continuous organic solution, in a form of
a plurality of discrete pores randomly dispersed within said polymeric porous coat,

wherein said microstructure is characterized by said plurality of discrete pores.

US Pat. No. 9,092,838

METHOD AND SYSTEM FOR PROCESSING AN IMAGE FEATURING MULTIPLE SCALES

Ramot at Tel-Aviv Univers...

1. A method of processing an image, comprising:
obtaining an image decomposed into a set of scaled images, each being characterized by a different image-scale;
for each of at least some scaled image of said set, calculating a relative luminance between said scaled image and another
scaled image of said set, using intensities in said scaled image and intensities in said another scaled image;

processing each scaled image of said set using an adaptation procedure featuring an image-specific effective saturation function
of said relative luminance, thereby providing a processed scaled image;

combining at least some of the processed scaled images to provide a combined image; and
outputting said combined image to a non-transitory computer readable medium.

US Pat. No. 10,237,974

METAL NANOWIRE THIN-FILMS

RAMOT AT TEL-AVIV UNIVERS...

1. A film comprising a plurality of nanowire bundles, each nanowire bundle comprising a plurality of conductive metal nanowires, the plurality of conductive metal nanowires comprising conductive metal nanowires having cross-sectional diameters between 3 and 5 nm and aspect-ratios of more than 500, wherein the conductive nanowires being a composite of 85-90% gold and 10-15% silver.

US Pat. No. 9,309,196

INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION

Ramot at Tel-Aviv Univers...

1. A compound of formula (I)

wherein
R1 is hydrogen, —C1-6-alkyl, —C(O)—R or —C(O)OR;

R2 is hydrogen, —C1-6-alkyl or cycloC3-12-alkyl;

R3 is —OR, —NHR or —NR2;

R4 is hydrogen, halogen, cyano, trifluoromethyl, or —C1-6-alkyl;

R5 is —C1-6-alkyl;

R6 is —C1-6-alkyl; or

R5 and R6 together with the carbon atoms carrying them form a cyclic system with 3 to 6 carbon atoms;

R is hydrogen, —C1-6-alkyl, or —C6-10-aryl;

X is a group —C(O)CH2—, —CH(OH)CH2—, —CH?CH— or —CH2—NH—C(O)—;

R7 is hydrogen, methyl, ethyl, propyl or cyclopropyl;

or an optical isomer or a pharmaceutically acceptable salt thereof.
US Pat. No. 9,289,453

TRANSPLANTATION OF CELLS INTO THE NASAL CAVITY AND THE SUBARACHNOID CRANIAL SPACE

Ramot at Tel-Aviv Univers...

1. A method of treating a cognitive disorder in a subject in need thereof, comprising transplanting a therapeutically effective
amount of pancreatic beta cells into the subarachnoid cavity, wherein said transplanting into said subarachnoid cavity is
performed between the frontal bone of the skull and the olfactory bulb of the subject, thereby treating the cognitive disorder.

US Pat. No. 9,173,568

METHOD AND SYSTEM FOR DETECTING NEUROPATHY

Ramot at Tel-Aviv Univers...

1. A system for diagnosing or monitoring neuropathy in a user, the system comprising:
a platform comprising a surface in which a two-dimensional array of stimulators is embedded, each stimulator being configured
to stimulate a region of user skin when applied to the platform;

a user feedback device configured to receive an input from the user about a location in the region of user skin where stimulation
caused by one or more stimulators of said two-dimensional array is sensed by the user, and to generate signals indicative
of the user input; and

a computer processing unit (CPU) configured to control the platform and activate said one or more stimulators, and to receive
from said user feedback device said signals indicative of the user input, and to process said signals and generate corresponding
data.

US Pat. No. 9,104,948

SYSTEM AND A METHOD FOR NANO IMPRINTING

Ramot at Tel-Aviv Univers...

1. A method of molding, comprising, creating a plurality of nanostructure mold replicas from a single nanostructure prototype,
wherein said nanostructure prototype provides a unique optical pattern when illuminated with a predefined illumination, and
wherein each nanostructure mold replica enables a creation of a nanostructure that is substantially similar to said nanostructure
prototype and which, when illuminated with the predefined illumination, provides the same unique optical pattern.

US Pat. No. 9,096,645

DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION

Ramot at Tel-Aviv Univers...

1. A dipeptide analog comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety, with the proviso that said
dipeptide analog is not a Trp-Aib dipeptide or ester thereof, wherein said beta sheet breaker moiety has a chemical structure
selected from the group consisting of:

and wherein said Trp moiety has a chemical structure selected from the group consisting of:

US Pat. No. 10,138,870

METHOD AND SYSTEM OF PROVIDING FLUID FLOW FOR A ROTOR

Ramot at Tel-Aviv Univers...

1. A rotor, comprising:a plurality of blades; and
a plurality of fluid routing devices, each mechanically connected to one of said plurality of blades and comprises:
a continuous channel with an inlet having a tip, and facing the opposite direction of rotation of said plurality of blades and an outlet, said continuous channel conducts fluid passing via said inlet and said inlet being placed in a lateral edge of said one of said plurality of blades, and
a flow directing element mechanically connected to said outlet so as to direct said conducted fluid into a duct inside said one of said plurality of blades to adjust a fluid flow in or on said blade;
wherein the inlet of each one of the plurality of fluid routing devices having an adjustable portion that shifts its tip in direction of the plane of said one of said plurality of blades when fluid flows via said inlet tip so that a phase shift is formed in an angle, a, between a leading segment of said one of said plurality of blades and said inlet tip, said phase shift increases a stagnation pressure as compared to that prevailing at the leading segment of said lateral edge.

US Pat. No. 9,465,103

METHOD AND SYSTEM FOR TARGET DETECTION

Ramot at Tel-Aviv Univers...

1. A method of detecting a physical target in a region-of-interest, comprising:
by an antenna or antenna array of a radiation transmitting-receiving system, transmitting a pulse of radiation into the region-of-interest,
and receiving an echo signal from the region-of-interest;

accessing, by a data processor, a computer readable medium storing a dictionary defined over a plurality of dictionary atoms
each describing a dictionary function corresponding to at least a time delay and a Doppler shift;

calculating, by the data processor, a coefficient for each dictionary function using said echo signal, thereby providing a
plurality of coefficients, wherein a linear combination of all dictionary functions respectively weighted by said coefficients
does not reconstruct said echo signal; and

determining, by the data processor, at least one of a range and a speed of the target based on said coefficients, and transmitting
a visual output indicative of said determination to a display.

US Pat. No. 9,192,670

REGULATION OF AMYLOID BETA MOLECULAR COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Ramot at Tel-Aviv Univers...

1. A method of treating Alzheimer's disease (AD) in a subject in need thereof, the method comprising:
(a) electrically stimulating a nerve pathway in a brain region of the subject with at least two high frequency spike bursts
of electrical currents, wherein a pattern of said high frequency spike bursts is a natural burst pattern of a healthy subject;
and

(b) administering to the subject an agent selected from the group consisting of a GABAB receptor agonist, an A1 receptor agonist, a metabotropic glutamate receptors group II agonist, an M2 muscarinic agonist, a CB1 endocannabinoid receptor agonist, Mu opioid receptor agonist, a voltage-dependent antagonist of voltage-gated calcium channels.

US Pat. No. 9,061,006

COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PHENYLKETONURIA (PKU)

Ramot at Tel-Aviv Univers...

1. A method of diagnosing Phenylketonuria (PKU) in a subject in need thereof, the method comprising detecting phenylalanine
fibrils in a tissue of the subject, wherein a presence or level above a predetermined threshold of said phenylalanine fibrils
in said tissue, is indicative of PKU in the subject.
US Pat. No. 10,086,354

FORMATION OF ORGANIC NANOSTRUCTURE ARRAY

Ramot at Tel-Aviv Univers...

1. A method of fabricating a nanostructure array, the method comprising dispensing on a substrate a solution of uncapped phenylalanine-phenylalanine dipeptides dissolved in an organic volatile solvent, and evaporating said solvent while generating conditions for self assembling of said peptide monomers such as to form peptide nanostructures arranged generally perpendicularly on said substrate, each of said peptide nanostructures being comprised of phenylalanine-phenylalanine peptides, wherein said substrate is a siliconized glass and said organic volatile solvent is hexafluoroisopropanol.

US Pat. No. 9,123,954

THREE-DIMENSIONAL MICROBATTERY HAVING A POROUS SILICON ANODE

RAMOT AT TEL-AVIV UNIVERS...

1. An electrical energy storage device, comprising:
a silicon substrate, which has opposing first and second surfaces and is formed so as to define a multiplicity of micro-containers
having porous silicon walls, which are configured to serve as an anode layer, the multiplicity of the micro-containers comprising
first and second sets of the micro-containers, which are respectively formed in the opposing, first and second surfaces of
the substrate in an interlaced pattern, in which the micro-containers in the first set are interdigitated with neighboring
micro-containers in the second set;

a cathode layer overlying and extending into only the first set of the micro-containers; and
a separator layer extending into only the first set of the micro-containers, intermediate the anode layer and the cathode
layer.

US Pat. No. 9,953,802

METHOD AND DEVICE FOR MANIPULATING PARTICLE BEAM

Ramot at Tel-Aviv Univers...

1. A method of manipulating a particle beam, comprising transmitting the beam through a phase mask selected to spatially modulate a phase of a wavefront of the beam over a cross-section thereof, wherein said phase mask has a non-uniform thickness that varies gradually or discretely across said phase mask and is characterized by a thickness function that does not exceed a critical point in which the accumulated phase equals a predetermined threshold.

US Pat. No. 9,141,875

METHOD AND SYSTEM FOR CORRECTING GAZE OFFSET

Ramot at Tel-Aviv Univers...

13. An imaging system, comprising:
(a) a camera for capturing an image of at least one individual having eyes; and
(b) a processer configured for:
processing the image so as to extract locations of at least one eye over the image, processing the image to replace imagery
data associated with each location of each eye with replacement data being previously-recorded imagery data respectively corresponding
to the same eye but a different gaze, wherein said replacing is based, at least in part, on eye parameters defining a shape
of said eye and being computed using a non-specific database of eye images, thereby providing a corrected image; and

transmitting said corrected image to a display device.

US Pat. No. 10,002,275

OPTICAL ELEMENT HAVING TWO PHASE MASKS

Ramot at Tel-Aviv Univers...

1. An optical element, comprising:a first phase shift mask formed on a first optical material and constituted to generate a positive phase shift, and
a second phase shift mask formed on a second optical material and constituted to generate a negative phase shift,
wherein said first mask forms an etched pattern of depth h1 in said first optical material, and said second mask forms a relief pattern of height h2 on said second optical material, wherein said phase shift masks are arranged serially on an optical axis, and wherein a refractive index of at least one of the first and second optical materials varies with the temperature at a rate of at least 50×10?6 per degree Kelvin.
US Pat. No. 9,925,143

LIPIDATED GLYCOSAMINOGLYCAN PARTICLES FOR THE DELIVERY OF NUCLEIC ACIDS

RAMOT AT TEL-AVIV UNIVERS...

1. A composition comprising water insoluble lipidated glycosaminoglycan particles comprising(i) a plurality of lipids forming a particulate lipid composition, wherein the plurality of lipids comprises monocationic lipid N-[1-(2,3-Dioleoyloxy)]-N,N,N-trimethylammonium propane (DOTAP), 1,2-dilauroyl-Lphosphatidyl-ethanolamine (DLPE), and cholesterol, wherein the relative molar amount of DOTAP is greater than the relative molar amount of DLPE and the relative molar amount of cholesterol, and wherein the relative amount of DLPE in the composition is 11% to about 25%, and
(ii) a nucleic acid encapsulated within the particles,
wherein the weight ratio of the nucleic acid to lipids is less than 1:1, and wherein the composition is not a liposome.

US Pat. No. 9,687,562

POLYMERS HAVING THERAPEUTICALLY ACTIVE AGENTS CONJUGATED THERETO, PROCESSES OF PREPARING SAME AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. A conjugate represented by the Formula:

wherein:
y ranges from 50 to 99.9 mol percent;
x ranges from 0.1 to 20 mol percent; and
n ranges from 0 to 10 mol percents.

US Pat. No. 9,243,034

GLYCOGEN SYNTHASE KINASE-3 INHIBITORS

Ramot at Tel-Aviv Univers...

1. A peptide having the amino acid sequence I:
[Yn . . . Y1]ZX1X2X3S(p)[W1 . . . Wm]  (I)

wherein,
m equals 1 or 2;
n is 3, 4, 5, 6 or 7, such that said peptide consists of 10 to 13 amino acid residues;
S(p) is a phosphorylated serine residue or a phosphorylated threonine residue;
Z is any amino acid residue excepting serine residue or threonine residue;
Y1-Yn and W1-Wm are each independently any amino acid residue;

each of X1 and X2 is independently a hydrophobic amino acid residue selected from the group consisting of glycine, alanine, leucine, isoleucine,
valine, proline, phenylalanine, methionine, cysteine and tryptophan; and

X3 is a proline residue.

US Pat. No. 10,130,682

METHODS OF USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT AND PREVENTION OF AGENT-INDUCED GONADAL OR UTERINE TOXICITY

Ramot at Tel-Aviv Univers...

5. A method of treating gonadal toxicity induced by an agent in a subject in need thereof, the method comprising:(a) administering to the subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF) peptide; and
(b) determining gonadal function in said subject, thereby treating the gonadal toxicity induced by the agent in the subject.

US Pat. No. 9,885,619

PUMP-POWER-INDEPENDENT DOUBLE SLOPE-ASSISTED DISTRIBUTED AND FAST BRILLOUIN FIBER-OPTIC SENSOR

Ramot at Tel-Aviv Univers...

1. A method for determining local variations in strain and/or temperature along an optical fiber, the method comprising:
obtaining a reference Brillouin gain spectrum (BGS) representative of steady state or average conditions in various locations
of the optical fiber along its length;

generating, based on the reference BGS, a probe wave being a complex waveform comprising a first and second set of waveforms,
each set having waveforms tailored to match an opposite slope of the reference BGS, at said various locations;

performing stimulated Brillouin scattering at said various locations by applying a pump pulse wave to said probe wave; and
deducing the local Brillouin frequency shift (BFS) at said various locations.
US Pat. No. 9,334,308

PLIF MULTIMERIC PEPTIDES AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. A dimer comprising two identical peptide monomers covalently linked to one another, each of said two peptide monomers comprising
the amino acid sequence as set forth in SEQ ID NO: 1, wherein said two peptide monomers are no longer than 30 amino acids,
wherein the dimer is capable of reducing binding of Placenta Immunomodulatory Factor (PLIF) to human leukocytes.
US Pat. No. 9,394,523

INDUCED PLURIPOTENT STEM CELLS DERIVED FROM HUMAN PANCREATIC BETA CELLS

Ramot at Tel-Aviv Univers...

1. A method of generating insulin producing cells, comprising:
(a) expanding human pancreatic beta cells so as to generate dedifferentiated cells which express a lower amount of insulin
or PDX-1 than differentiated pancreatic beta cells as assayed by Immunohistochemistry or RT-PCR; and subsequently

(b) generating induced pluripotent stem (iPS) cells from said dedifferentiated cells by expressing OCT4, SOX2, KOF4 and cMYC,
wherein said iPS cells have an open chromatin structure in either the PDX-1 or insulin promoter; and

(c) differentiating said induced pluripotent stem cells into insulin producing cells.

US Pat. No. 9,368,875

ANTENNA SYSTEM AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. An antenna system, comprising a first end-fire antenna element and a second end-fire antenna element facing each other
in a planar arrangement, said antenna elements having a thickness which is larger than a skin depth of a material forming
said antenna elements, said antenna elements being positioned to form one or more air gaps therebetween, and being configured
to cause destructive interference between individual end-fire radiations of said elements, while maintaining constructive
interference generally perpendicular to said planar arrangement.
US Pat. No. 10,052,363

MESENCHYMAL STEM CELLS FOR THE TREATMENT OF CNS DISEASES

Ramot at Tel-Aviv Univers...

1. A method of treating a neurodegenerative disorder comprising administering to the central nervous system of an individual in need thereof a therapeutically effective amount of non-genetically modified human cells which express at least one mesenchymal stem cell marker and secrete brain-derived neurotrophic factor (BDNF) and glial derived neurotrophic factor (GDNF), and do not secrete nerve growth factor (bNGF), wherein said at least one mesenchymal stem cell marker is selected from the group consisting of CD73, CD90 and CD105, wherein a basal secretion of said GDNF in the cells is at least two times greater than a basal secretion of said GDNF in non-differentiated, non-genetically modified human mesenchymal stem cells, wherein the neurodegenerative disease is selected from the group consisting of Parkinson's Disease, amyotrophic lateral sclerosis (ALS) and Huntington's disease, wherein said non-genetically modified human cells are differentiated ex vivo from bone marrow derived mesenchymal stem cells.
US Pat. No. 9,394,628

METHOD OF FORMING A FIBER MADE OF PEPTIDE NANOSTRUCTURES

Ramot at Tel-Aviv Univers...

1. A fiber comprising a plurality of peptide nanostructures, wherein each peptide in each of said plurality of peptide nanostructures
comprises no more than 4 amino acids, at least one of said 4 amino acids being an aromatic amino acid, the fiber being at
least 100 nm in length.

US Pat. No. 9,575,068

METHOD AND SYSTEM FOR DETECTING A TARGET WITHIN A POPULATION OF MOLECULES

Ramot at Tel-Aviv Univers...

1. A method of detecting at least one target molecule within a population of molecules, the method comprising:
contacting a plurality of labeled probe molecules, each selectively binds to at least one target molecule, with the population
of molecules potentially containing a target of said at least one target molecule;

directing an excitation beam in a first direction through the plurality of probe molecules, thereby producing a background
signal and potentially a probe specific signal emitted if at least one of said plurality of labeled probe molecules is bound
to at least a portion of said target;

detecting said probe specific signal over said background signal by performing a preferential modulation to at least one of
said acquisition and an emission of said probe specific signal, wherein said preferential modulation includes moving the at
least one of said plurality of labeled probe molecules bound to at least a portion of said target in a second direction, in
and out of the excitation beam, wherein said detecting according to said probe specific signal includes detecting relative
movement between the excitation beam and the target molecule, wherein said relative movement results in the labeled probe
molecules bound to at least the portion of the target being positioned in and out of the excitation beam, and;

detecting at least one of the presence, the absence and the amount of said at least one target molecule in said target according
to said probe specific signal.

US Pat. No. 9,543,385

HEAVILY DOPED SEMICONDUCTOR NANOPARTICLES

YISSUM RESEARCH DEVELOPME...

1. A nanoparticle comprising
a semiconductor material, the semiconductor material being doped with at least two atoms of a dopant material, wherein
the at least two atoms of the dopant material are heterovalent to atoms of the semiconductor material, said at least two atoms
of the dopant material being dispersed within the semiconductor material, and

the nanoparticle is free of dopant islands within the nanoparticle and free of dopant islands on the surface of the nanoparticle.

US Pat. No. 9,459,148

SNAPSHOT SPECTRAL IMAGING BASED ON DIGITAL CAMERAS

Ramot at Tel-Aviv Univers...

1. An optical element for use in a spectral imaging system comprising: a patterned structure that modifies a point spread
function (PSF) of the spectral imaging system at each wavelength in a spectral range such that a resulting linear transformation
of a source object into a diffused and dispersed image at an image sensor satisfies a restricted isometry property (RIP) condition.
US Pat. No. 9,181,555

PHOTOCATALYTIC HYDROGEN PRODUCTION AND POLYPEPTIDES CAPABLE OF SAME

Ramot at Tel-Aviv Univers...

1. An isolated polypeptide comprising an algal Fe-only hydrogenase attached to an algal ferredoxin, comprising an amino acid
sequence as set forth in SEQ ID NOs: 23, 25 or 27.
US Pat. No. 9,427,474

CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES

Ramot at Tel-Aviv Univers...

1. A conjugate comprising a polymeric backbone having attached thereto an anti-angiogenesis agent and a bisphosphonate bone
targeting moiety, said polymeric backbone being derived from a polymer selected from the group consisting of dextran, a water
soluble polyamino acid, a polyethylenglycol (PEG), a polyglutamic acid (PGA), a polylactic acid (PLA), a polylactic-co-glycolic
(PLGA), a poly(D,L-lactide-co-glycolide) (PLA/PLGA), a polyglycerol, a polyamidoamine (PAMAM), and a polyethylenimine (PEI),
the conjugate being represented by the general formula I:
[A1]x[A2-L1-B]y[A3-L2-D]w  Formula I

wherein:
x is an integer having a value such that x/(x+y+w) multiplied by 100 is in the range of from 70 to 99.8;
y is an integer having a value such that y/(x+y+w) multiplied by 100 is in the range of from 0.1 to 15; and
w is an integer having a value such that w/(x+y+w) multiplied by 100 is in the range of from 0.1 to 15,
A1, A2, and A3 are each backbone units covalently linked to one another and forming said polymeric backbone, wherein:

B is said anti-angiogenesis agent;
D is said bone targeting moiety; and
each of the L1 and L2 is independently a linker or absent;

such that [A2-L1-B] is a backbone unit having attached thereto said anti-angiogenesis agent; and

[A2-L2-D] is a backbone unit having attached thereto said bone targeting moiety;

wherein each of the [A1], the [A2-L1-B] and the [A3-L2-D] is either a terminal backbone unit being linked to one of the [A1], the [A2-L1-B] and the [A3-L2-D], or is linked to at least two of the [A1], [A2-L1-B] and the [A3-L2-D], whereby A1, A2 and/or A3 are linked to one another to thereby form said polymeric backbone.

US Pat. No. 9,335,820

METHOD AND SYSTEM FOR CORRECTING GAZE OFFSET

Ramot at Tel-Aviv Univers...

1. A method of correcting gaze offset in an image of at least one individual having eyes, comprising:
processing the image so as to extract location of at least one eye over the image;
determining whether an eyelid of said at least one eye is close or open; and
conditionally to a determination that said eyelid is open, processing the image to replace imagery data associated with each
location of each eye with replacement data, said replacement data being previously-recorded imagery data which respectively
correspond to the same eye but a different gaze, thereby providing a corrected image, and transmitting said corrected image
to a display device.

US Pat. No. 9,228,991

METHODS AND KITS FOR DETECTION OF DRUGS

RAMOT AT TEL-AVIV UNIVERS...

1. A method for determining the presence/absence of a drug in a liquid medium, the method comprising:
providing one or more solvent mixture(s) having a predetermined optical parameter, said solvent mixture(s) being capable of
undergoing a change in at least one optical parameter in the presence of a drug; and

contacting said solvent mixture with a liquid medium sample suspected of containing an amount of said drug;
whereby a change in the predetermined optical parameter of said solvent mixture following the contacting thereof with said
liquid medium sample, indicates the presence of said drug in said liquid medium,

wherein the change in the predetermined optical parameter being dependent on the full or partial insolubility of the drug
in the solvent mixture.

US Pat. No. 9,243,032

COMPOSITIONS FOR TREATMENT OF NEURODEGENERATIVE DISEASES

Ramot at Tel-Aviv Univers...

1. A peptide being less than 20 amino acids in length, the peptide comprising the amino acid sequence as set forth in SEQ
ID NO: 55.

US Pat. No. 9,158,990

SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR MOTION DETECTION USING SETS OF TRINARY BITS

RAMOT AT TEL-AVIV UNIVERS...

1. A method for motion detection, the method comprises:
receiving multiple frames;
generating a set of digits for each pixel of multiple pixels of each frame of the multiple frames to provide sets of digits;
wherein each set of digits represents a pixel that belongs to a patch of a frame and represents relationships between (a)
first similarities between the patch and a set of patches of a next frame that are located in locations that differ from each
other and differ from a location of the patch; and (b) second similarities between the patch and a set of patches of a previous
frame that are located in locations that differ from each other and differ from a location of the patch;

and
processing the sets of digits to detect motion;
wherein the generating of the sets of digits comprises generating sets of trinary digits;
wherein each trinary digit of the set of trinary digits represents a relationship between (a) a first similarity between the
patch and a next patch of the set of patches of the next frame; and (b) a second similarity between the patch and a previous
patch of the set of patches of the previous frame, wherein the next patch and the previous patch are located at the same location;

wherein the generating of sets of trinary digits comprises:
assigning a first value to the trinary digit if the first similarity is more significant that the second similarity;
assigning a second value to the trinary digit if the second similarity is more significant that the first similarity; and
assigning a third value to the trinary digit if the first similarity is equal to the second similarity.
US Pat. No. 9,730,998

TILAPIA LAKE VIRUS VACCINES

Ramot at Tel-Aviv Univers...

1. A vaccine composition comprising an attenuated strain of Tilapia Lake Virus (TiLV) for protecting tilapia fish against infection by (TiLV), wherein the attenuated strain is obtained by at least 12 sequential passages in tissue culture.

US Pat. No. 9,405,119

IMAGING SYSTEM AND METHOD FOR IMAGING OBJECTS WITH REDUCED IMAGE BLUR

RAMOT AT TEL-AVIV UNIVERS...

1. An imaging system comprising:
an imaging device comprising a basic lens system and a phase encoder unit, the imaging device defining an effective aperture,
the phase encoder unit defining a first pattern located in a first region within a part of the effective aperture of the imaging
device leaving a remaining part of the effective aperture free of the first pattern, a geometry of the first region and configuration
of the first pattern therein being selected to define a predetermined first phase correction function induced by the first
pattern onto light passing therethrough, the first correction pattern being selected in accordance with a Condition Number
defined by an algebraic representation of the imaging device;

an image detection unit located at an image plane of the imaging device and configured to generate image data based on light
collected by the imaging device; and

a control system configured and operable to: (i) receive image data from the image detection unit, and (ii) process and analyze
the image data to determine and output a restored image in accordance with the algebraic representation of the imaging device
such that the restored image has reduced image blur.

US Pat. No. 9,403,756

N-PHENYL ANTHRANILIC ACID DERIVATIVES AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. A method of blocking a transient receptor potential vanilloid 1 (TRPV1) in a subject in need thereof, the method comprising
administering to the subject a therapeutically effective amount of a compound represented by Formula IV:
wherein:
Z is an A-G(=K)—X—Y group,and wherein:
A is alkyl or absent;
G is selected from the group consisting of C, S and PRa;
K is selected from the group consisting of O and S;
X is selected from the group consisting of NRb, O, S or absent; and
Y is selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, cycloalkyl, heteroalicyclic, aryl and a polyalkylene
glycol residue,

R1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl or aryl;

each of R2, R3, R4, R5, R6, R7, R8, R9 and R10 is independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl,
aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl,
cyano, nitro, an electron-withdrawing group, amino and —NR15R16, or, alternatively, at least two of R2, R3, R4, R5 and R6, of R7, R8, R9 and R10 form a five- or six-membered aromatic, heteroaromatic, alicyclic or heteroalicyclic ring;

R15 and R16 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl and sulfonyl, or,
alternatively R15 and R16 form a five- or six-member heteroalicyclic ring; and

each of said Ra and Rb is selected from the group consisting of hydrogen, alkyl, cycloalkyl and aryl,
wherein said electron-withdrawing group is selected from the group consisting of nitro, ammonium, cyano, halo, trihaloalkyl,
sulfonate, a —C(?O)X group wherein X is halide, a carboxy moiety, and a —C(?O)—R? group wherein R? is hydrogen, alkyl, cycloalkyl
and aryl, said carboxy group being selected from carboxylate, amide, thiocarboxylate, dithiocarboxylate, thioamide, imide,
N-substituted imide, thioimide and amidine.

US Pat. No. 9,213,882

DEVICES AND METHODS OF READING MONOCHROMATIC PATTERNS

Ramot at Tel-Aviv Univers...

1. A device of extracting data from an identifiable monochromatic pattern, said device comprising:
an optical assembly having a mask with at least one concentric ring for separating a polychromatic optical signal received
from an object with an identifiable monochromatic pattern into a plurality of wavelength components;

an image sensor which separately captures each of said plurality of wavelength components in one of a plurality of color channels;
and

a processing unit which reconstructs a plurality of images each from a different color channel of said plurality of color
channels that includes a different wavelength component of said plurality of wavelength components, detects said identifiable
monochromatic pattern in at least one of said plurality of images, and extracts data associated with or encoded by said identifiable
monochromatic pattern;

wherein each of said plurality of images has a different depth of field, wherein said at least one concentric ring for optically
delivering an exhibited phase shift of ? (modulus 2?) for a first wavelength component a phase shift of 0 (mod 2?) for the
second wavelength component, and an exhibited phase shift of ?/2 (mod 2?) for the third wavelength component.

US Pat. No. 10,036,686

METHOD AND SYSTEM FOR AN ULTIMATELY FAST FREQUENCY-SCANNING BRILLOUIN OPTICAL TIME DOMAIN ANALYZER

Ramot at Tel-Aviv Univers...

1. A method comprising:simultaneously launching two pairs of optical signals into an optical fiber, each pair comprising a pulsed pump wave and a counter-propagating constant wave (CW) probe wave, wherein the pulsed pumps have orthogonal States of Polarization (SOPs), and wherein the two CW probe waves have a same SOP;
scanning common pump-probe frequency difference, over a frequency range that encompasses a respective Brillouin Gain Spectrum (BGS) and current and expected spectral shifts of the BGS in a plurality of locations along the optical fiber;
deriving, a local Brillouin Frequency Shift (BFS), in said plurality of locations along the optical fiber, wherein said local BFS is the pump-probe frequency difference which maximizes the Brillouin gain on the BGS;
determining strain and/or temperature in said plurality of locations along the optical fiber, based on the respective local BFS; and
evaluating dynamic structural changes to a structure to which the optical fiber is attached thereto, or planted therein, based on the determined strain or temperature.

US Pat. No. 9,193,398

METHODS AND APPARATUS FOR REDUCTION OF AERODYNAMIC DRAG

Ramot at Tel-Aviv Univers...

1. An apparatus adapted to reduce aerodynamic drag on a vehicle moving through a fluid, the apparatus comprising:
(a) an apparatus housing including:
a first outer surface adapted to extend outward with a downward inclination from an upper edge of the vehicle while the housing
is mounted on a trailing surface of the vehicle; and

a second outer surface adapted to extend outward at substantially right angles from the trailing surface of the vehicle from
a location below the upper edge; and

(b) a flow generator within the housing, the flow generator adapted to generate at least one flow which controls an external
flow at an edge of the vehicle on which the apparatus housing is mounted.

US Pat. No. 10,071,983

ACTIVATABLE FLUOROGENIC COMPOUNDS AND USES THEREOF AS NEAR INFRARED PROBES

Ramot at Tel-Aviv Univers...

1. A fluorogenic compound comprising three acceptor-containing moieties and a donor-containing moiety arranged such that:(i) said three acceptor-containing moieties and said donor-containing moiety form a conjugated ?-electron system devoid of resonating electrons, such that the compound is incapable of emitting NIR infrared light; and
(ii) upon a chemical event, said donor-containing moiety rearranges so as to transfer ?-electrons to one of said acceptor-containing moieties and, as a result, said acceptor-containing moiety becomes a donor-containing moiety to the other acceptor-containing moieties, to thereby enable emission of near infrared light,
wherein each of said acceptor-containing moieties is independently selected from an ammonium form of an indolenine or an ammonium form of a pyridine,
and wherein said donor containing moiety comprises an aryl substituted by at least one electron-donating group, and is such that upon said chemical event, it rearranges by undergoing a quinonemethidine-like rearrangement,
said donor-containing moiety being independently linked to each of said three acceptor-containing moieties either directly or via a linking moiety, said linking moiety comprising a carbomethine-containing chain of at least one —CR??CR?— moiety, wherein R? and R? are each independently hydrogen, alkyl or cycloalkyl, or, alternatively, R? and R? form together an aryl, and is such that said acceptor-containing moieties and said donor containing moiety form said conjugated ?-electron system.

US Pat. No. 9,734,638

THREE-DIMENSIONAL MODELING FROM SINGLE PHOTOGRAPHS

Ramot at Tel-Aviv Univers...

1. A method of obtaining a three-dimensional digital model of an artificial object, the artificial object made up of a plurality
of two-dimensional geometric primitives, the artificial object being in a single two-dimensional photograph or drawing in
a plane, the method comprising:
defining a two-dimensional outline of said artificial object within the photograph or drawing;
interactively allowing a user to define cross-sectional profiles of successive ones of said geometric primitives within said
artificial object, said cross-sectional profiles being perpendicular to said plane, thereby defining a third dimension relative
to said photograph or drawing;

interactively allowing a user to provide sweep input to define sweeps of respectively defined cross-sectional profiles along
extents of corresponding ones of said two-dimensional geometric primitives within the artificial object, said sweeps being
defined in respective directions parallel to said plane;

carrying out sweeping of said cross-sectional profiles along said extents parallel to said plane according to said sweep input;
dynamically adjusting said profiles using a pictorial context on the photograph or drawing and automatically snapping photograph
lines to said profiles during said sweeping;

said sweeping generating successive thee-dimensional model primitives from existing detected edges of said corresponding two-dimensional
geometric primitives and said sweeping of said respective profiles; and

aligning said plurality of three-dimensional model primitives to form said three-dimensional model.
US Pat. No. 9,717,772

INTERVAL THERAPY FOR THE TREATMENT OF LOSS OF EYESIGHT IN HUMANS WITH GLAUCOMA AND OTHER DEGENERATIVE EYE DISEASES

Ramot at Tel-Aviv Univers...

1. A method for the treatment of at least one optical condition associated with ?-amyloid (A?) toxicity in a subject in need
thereof, the method comprising administering to the subject the peptide D-Trp-Aib (SEQ ID NO. 30), which peptide is administered
daily for a first period of at least one (1) day in at least a therapeutically effective dose, followed by a second period
of at least one (1) week wherein the peptide is not administered,
followed by repeating said first period of at least one (1) day wherein said peptide is administered daily, wherein said peptide
is not administered as a depot,

and wherein said at least one optical condition is selected from the group consisting of primary angle-closure glaucoma, secondary
open-angle glaucoma, wide-angle glaucoma, steroid-induced glaucoma, traumatic glaucoma, pigmentary dispersion syndrome, pseudo-exfoliation
syndrome, secondary angle-closure glaucoma, neovascular glaucoma, uveitis and glaucoma, age-related macular degeneration,
and diabetic retinopathy.

US Pat. No. 9,095,618

CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES

Ramot at Tel-Aviv Univers...

1. A conjugate comprising a polymeric backbone derived from polyglutamic acid (PGA) and comprising a plurality of backbone
units covalently linked to one another, wherein a portion of said plurality of backbone units has an anti-angiogenesis agent
attached thereto, and another portion of said plurality of backbone units has a bisphosphonate bone targeting moiety attached
thereto, the conjugate being represented by the general formula I:
[A1]x[A2-L1-B]y[A3-L2-D]w  Formula I

wherein:
x is an integer having a value such that x/(x+y+w) multiplied by 100 is in the range of from 70 to 99.8;
y is an integer having a value such that y/(x+y+w) multiplied by 100 is in the range of from 0.1 to 15; and
w is an integer having a value such that w/(x+y+w) multiplied by 100 is in the range of from 0.1 to 15,
A1, A2 and A3 are each backbone units covalently linked to one another and forming said polymeric backbone, wherein:

B is said anti-angiogenesis agent;
D is said bone targeting moiety; and
each of the L1 and L2 is independently a linker or absent;

such that [A2-L1-B] is a backbone unit having attached thereto said anti-angiogenesis agent; and

[A2-L2-D] is a backbone unit having attached thereto said bone targeting moiety;

wherein each of the [A1], the [A2-L1-B] and the [A3-L2-D] is either a terminal backbone unit being linked to one of the [A1], the [A2-L1-B] and the [A3-L2-D], or is linked to at least two of the [A1], the [A2-L1-B] and the [A3-L2-D], whereby A1, A2 and/or A3 are linked to one another to thereby form said polymeric backbone.

US Pat. No. 10,265,412

ENZYME REPLACEMENT THERAPY FOR TREATING LYSOSOMAL STORAGE DISEASES

Ramot at Tel-Aviv Univers...

1. A chimeric protein for the delivery of a therapeuticenzyme across the blood brain barrier, the chimeric protein comprising a protein hormone which is granulocyte colony stimulating factor (G-CSF) or a precursor or an active fragment thereof having an the amino acid sequence as set forth in any one of SEQ ID NOSs: 5-6 and 9-10,
covalently linked to a therapeutic enzyme which is ?-hexosaminidase A (HEXA) or a precursor or active fragment thereof, having the amino acid sequence as set forth in any one of SEQ ID NOS: 13-16, wherein the G-CSF is able to cross the blood brain barrier; and wherein ?-hexosaminidase A is an enzyme whose deficiency is linked to GM2-gangliosidosis type I/TaySachs disease.

US Pat. No. 9,403,030

LOW LEVEL LASER THERAPY FOR ALZHEIMER'S DISEASE

RAMOT AT TEL-AVIV UNIVERS...

1. An apparatus for administration of biostimulatory phototherapy radiation to a bone of a subject, the apparatus comprising:
a transparent output interface,
an appliance adapted to hold the output interface into contact with a skin surface overlying the bone or into contact with
the bone; and

a source of coherent light, which is configured to emit the radiation through the output interface so as to irradiate marrow
of the bone at a sufficient intensity to improve brain function when the source of coherent light avoids irradiating a brain
of the subject.

US Pat. No. 9,784,731

METHODS OF MONITORING AND ANALYZING METABOLIC ACTIVITY PROFILES DIAGNOSTIC AND THERAPEUTIC USES OF SAME

Ramot at Tel-Aviv Univers...

1. A method of diagnosing and treating solid cancer in a subject-in-need thereof, the method comprising:
(a) providing a biological sample of the subject which comprises non-pathogenic lymphocytes;
(b) measuring acidification in an extracellular defined solution having a calibrated buffered capacity of said non-pathogenic
lymphocytes in a time-dependent manner so as to generate a time dependent acidification profile,

wherein said at least one time dependent acidification profile is due to secretion of:
(i) non-volatile soluble metabolic products and volatile soluble metabolic products;
(ii) non-volatile soluble metabolic products; or
(iii) volatile soluble metabolic products,
wherein measuring acidification profile of said (ii) is effected in an air-exposed chamber, and wherein measuring acidification
profile of said (i) is effected in an air-sealed chamber, and wherein measuring acidification profile of said (iii) is by
subtracting an acidification profile of said (ii) from an acidification profile of said (i), wherein a statistically significant
change in said time dependent acidification profile as compared to that in a control unaffected sample obtained under identical
conditions, is indicative of a solid cancer diagnosis; and

(c) treating the subject with an anti cancer agent to the solid tumor.

US Pat. No. 9,341,630

ACTIVATABLE FLUOROGENIC COMPOUNDS AND USES THEREOF AS NEAR INFRARED PROBES

Ramot at Tel-Aviv Univers...

1. A fluorogenic compound comprising at least two acceptor-containing moieties and a donor-containing moiety arranged such
that:
(i) said at least two acceptor-containing moieties and said donor-containing moiety form a conjugated ?-electron system devoid
of resonating electrons, such that the compound is incapable of emitting NIR infrared light; and

(ii) upon a chemical event, said donor-containing moiety rearranges so as to transfer ?-electrons to one of said acceptor-containing
moieties and, as a result, said acceptor-containing moiety becomes a donor-containing moiety to at least one another acceptor-containing
moiety, to thereby enable emission of near infrared light,

the fluorogenic compound having the general Formula I:

wherein:
Q1 and Q2 are each independently an acceptor-containing moiety, and A1 and A2 are each an acceptor group in said acceptor-containing moieties, said acceptor group being an ammonium ion and said acceptor-containing
moiety being independently a substituted or unsubstituted, positively charged, nitrogen-containing heterocyclic moiety represented
by

wherein R is hydrogen, alkyl and cycloalkyl, at least one of said Q1 and Q2 being an ammonium form of an indolenine or ammonium form of a pyridine;
Z and Y form said donor-containing moiety, said donor-containing moiety comprising an aryl substituted by at least one electron-donating
group, and is such that upon said chemical event, it rearranges by undergoing a 1,4-quinonemethidine-like rearrangement; and;

L1 and L2 are each independently a linking moiety or absent, said linking moiety comprising a carbomethine-containing chain of at least
one —CR??CR?—moiety, whereine R? and R? are each independently hydrogen, alkyl or cycloallkyl, or alternatively, R? and R?
form toegther an aryl,

wherein said donor-containing moiety forms a part of, or is attached to, said carbomethine-containing chain and wherein each
of L1 and L2 is such that said Q1 and Q2 acceptor-containing moieties and said Z-Y donor containing moiety form said conjugated-?-electron system.

US Pat. No. 9,624,291

BI- AND MONOSPECIFIC, ASYMMETRIC ANTIBODIES AND METHODS OF GENERATING THE SAME

Ramot at Tel-Aviv Univers...

1. A method of preparing a bispecific antibody comprising an Fc region and a Fab region,
(a) providing a first nucleic acid molecule encoding a first heavy chain having a tryptophan at position 366 on a CH3 domain so as to generate a protuberance;

(b) providing a second nucleic acid molecule encoding a second heavy chain having a serine at position 366, an anlanine at
position 368 and a valine at position 407 on a CH3 thereof wherein the VH domain of said second heavy chain further comprises a cysteine at position 44 and an alanine at position 222;

(c) providing a third nucleic acid molecule encoding a native first light chain;
(d) providing a fourth nucleic acid molecule encoding a second light chain, wherein the VL domain thereof has a cysteine at position 100 and has a cysteine deletion at the position of its native disulfide bond with
said second heavy chain;

(e) culturing host cells comprising said first, second, third and fourth nucleic acid molecules under conditions that permit
expression of the nucleic acid molecules; and

(f) recovering the antibody,
wherein the numbering of said position is according to Kabat and Wu.

US Pat. No. 10,054,562

MOLECULAR SENSOR BASED ON VIRTUAL BURIED NANOWIRE

Ramot at Tel-Aviv Univers...

1. A method of sensing molecules in a gas or liquid sample with a multi-gate field effect transistor having a conducting channel connecting a source region to a drain region, a position of the conducting channel in a lateral direction controllable by changing two lateral gate voltages, and the conductivity of the conducting channel affected by the molecules adhering to a sensing surface of the transistor at a position near the conducting channel, the method comprising:a) exposing the sensing surface to the gas or liquid sample;
b) changing the position of the conducting channel in the lateral direction, and measuring a conductivity of the channel at a plurality of positions of the channel; and
c) detecting the molecules by observing a change in conductivity of the conducting channel when it is in a position such that it passes close to one of the adhering molecules, or close to a fluctuation in a concentration of the adhering molecules on the sensing surface.
US Pat. No. 9,598,785

NANOSTRUCTURES AND PROCESS OF PREPARING SAME

Ramot at Tel-Aviv Univers...

1. A process of preparing a plurality of nanostructures, each having a base surface and a top surface, and being composed
of at least three different target materials arranged layerwise across a thickness direction thereof such that said layers
are exposed at a periphery of said nanostructure between said base surface and said top surface, at least one of said target
materials being an electropolymerized polymer or a semiconductor material selected from the group consisting of CdTe, CdS,
CdSe, ZnS, ZnO, GaAs, ZnTe, CdTeSe, GaAs, gallium phosphide, gallium nitride, TiO2, and TiS2, wherein at least one of said nanostructures comprises a polyaniline segment and a polypyrrole segment, the process comprising:
depositing a blocking layer onto a first side of a porous membrane having pores of nanometric diameter, so as to substantially
block said pores from said first side while leaving said pores open from a second side of said membrane;

sequentially electrodepositing a first material and said at least two target materials into said open pores, to thereby obtain
within said pores nanometric rods, each of said nanometric rods having a plurality of segments wherein any two adjacent segments
are made of different materials; and

etching said membrane and said first material, thereby obtaining the nanostructures.
US Pat. No. 9,821,089

COMPOSITES COMPRISING COLLAGEN EXTRACTED FROM SARCOPHYTON SP. CORAL

Ramot at Tel-Aviv Univers...

1. An isolated composite comprising bundles of collagen fibers embedded in a matrix, said collagen fibers being isolated from
a Sarcophyton sp. coral, and said matrix comprising a material selected from the group consisting of a polysaccharide, a polypeptide, polylipid,
a synthetic polymer, a metal and a mineral, wherein said bundle of collagen fibers comprise woven fibers, twisted fibers,
braided fibers, knitted fibers, tied fibers, or sutured fibers.

US Pat. No. 9,995,678

QUANTITATIVE ASSESSMENT OF SOIL CONTAMINANTS, PARTICULARLY HYDROCARBONS, USING REFLECTANCE SPECTROSCOPY

Ramot at Tel-Aviv Univers...

1. Method for quantitative assessment of chemical constituents of a substance using reflectance spectroscopy, the method comprising:obtaining a plurality of samples of said substance, the samples having respective chemical constituents;
spectrally analyzing each sample of said substance using reflectance spectroscopy, said reflectance spectroscopy obtaining spectroscopy data of said respective sample;
applying to said sample spectroscopy data of each respective sample of said substance a plurality of combinations from a set of preprocessing operations;
removing ones of said combinations;
from each remaining combination generating a respectively different version of said sample spectroscopy data, each version being a respective perturbation of the sample spectroscopy data, each perturbation thereby being generated according to a respective one of said combinations of preprocessing operations, wherein said set of preprocessing operations comprises initial smoothing, multiplicative scatter correction, signal normal variate, absorption, continuum removal, first derivative, second derivative, and final smoothing;
using all of said perturbations, generating a model relating said preprocessed spectral data to respective chemical constituents, and
using said model with spectroscopy data of an additional sample of said substance having unknown chemical constituents to determine respective unknown chemical constituents thereby characterizing the chemical constituents of said additional sample of said substance.

US Pat. No. 9,493,587

METAL COMPLEXES OF SALAN-TYPE LIGANDS AND USES THEREOF AS CATALYSTS FOR POLYMERIZATION OF ALPHA-OLEFINS

Ramot at Tel-Aviv Univers...

1. A process of polymerizing an alpha-olefin, the process comprising contacting the alpha-olefin with a catalyst system which
comprises:
(i) a pre-catalyst comprising a group 4 element being in coordination with a Salan ligand, said Salan ligand comprising two
substituted or unsubstituted phenol moieties and a sequential diamino-containing skeleton unit linking said phenol moieties,
wherein said sequential diamino-containing skeleton unit is non-symmetric and said pre-catalyst is devoid of a symmetry element;
and

(ii) a co-catalyst,
thereby polymerizing the alpha-olefin.

US Pat. No. 9,496,783

PARTIAL ARBITRARY MATRIX TOPOLOGY (PMAT) AND GENERAL TRANSPOSED SERIAL-PARALLEL TOPOLOGY (GTSP) CAPACITIVE MATRIX CONVERTERS RELATED APPLICATIONS

RAMOT AT TEL-AVIV UNIVERS...

1. A direct current (DC) to DC converter, comprising: input ports for receiving an input DC voltage; output ports for outputting
an output DC voltage; a first matrix of capacitors and switches; and a control circuit, coupled to the switches of the first
matrix, configured to repetitively:
configure the first matrix to a charge configuration and couple the first matrix to the input ports;
maintain the charge configuration for a first period of time;
configure the first matrix to the discharge configuration and couple the first matrix to the output ports; and
maintain the discharge configurations for a second period of time;
wherein the charge configuration and the discharge configurations of the first matrix differ from each other by a replacement
of serial connections of capacitors of the matrix to parallel connections of capacitors of the matrix;

wherein the charge configuration and a discharge configuration the first matrix are responsive to required conversion ratio
between the input DC voltage and the output DC voltage;

wherein different required conversion ratios result in different charge and discharge configurations; and wherein the first
matrix comprises at least four capacitors; and

wherein the first matrix comprises a modular cell, wherein the modular cell comprises a first switch, coupled between a first
port and a sixth port; a second switch, coupled between the sixth port and a second port; a capacitor, coupled between the
second port and a third switch; said third switch is coupled between the capacitor and a fifth port; a fourth switch coupled
between the capacitor and a third port; and a fifth switch coupled between the third port and a fourth port.

US Pat. No. 9,421,172

LIPIDATED GLYCOPROTEIN PARTICLES AND METHODS OF USE

RAMOT AT TEL-AVIV UNIVERS...

1. A method for treating a patient suffering from osteoarthritis, comprising administering to the patient in need thereof
an effective amount of a lipidated glycoprotein microparticle or macroparticle encapsulating diclofenac, wherein the lipidated
glycoprotein microparticle or macroparticle has a solid porous interior and comprises the reaction product of at least one
amino-containing glycoprotein covalently bound with at least one lipid having a primary amino group.
US Pat. No. 10,000,737

GENERATION OF CYTOTOXIC TUMOR SPECIFIC CELL LINES AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. An in-vitro method of activating T cells, the method comprising incubating tumor-specific T cells with allogeneic HLA-A2 matched tumor cells in the presence of a dimer comprising two identical peptide monomers covalently linked to one another, each of said two peptide monomers comprising the amino acid sequence as set forth in SEQ ID NO: 1, wherein said two peptide monomers are each no longer than 30 amino acids, wherein said method is carried out under conditions which allow expansion of said tumor-specific T cells.

US Pat. No. 9,786,943

DIRECT LIQUID FUEL CELL HAVING AMMONIA BORANE, HYDRAZINE, DERIVATIVES THEREOF OR/AND MIXTURES THEREOF AS FUEL

Ramot at Tel-Aviv Univers...

1. A fuel cell system comprising an anode compartment which comprises an anode having a copper catalyst layer, a cathode configured
as an air cathode, and a solid electrolyte membrane interposed between said anode and said cathode, the fuel cell being operable
by contacting the anode with an amine-derived fuel and contacting the cathode with oxygen or air, wherein said air cathode
comprises a metal complex which is a cobalt porphyrin complex.

US Pat. No. 9,788,753

METHOD AND SYSTEM FOR CHARACTERIZING CORTICAL STRUCTURES

Ramot at Tel-Aviv Univers...

1. A method of identifying brain structures, comprising:
using magnetic resonance imaging system for imaging the cortex of the brain via inversion recovery magnetic resonance imaging,
said imaging comprises applying to the brain energy that is resonantly absorbed in the brain, said energy being applied as
a resonance pulse sequence selected such that, for each of at least two areas or regions in the cortex, a longitudinal magnetization
of the respective area or region is suppressed compared to a longitudinal magnetization of all other areas or regions, wherein
each of these areas or regions is characterized by a different characteristic recovery time;

using an image processor for classifying said at least two areas or regions to a laminar pattern based on characteristic recovery
time and associating said at least two areas or regions with different brain structures, thereby identifying brain structures;
and

graphically displaying said identified laminar patterns on a display.
US Pat. No. 9,534,201

CULTURE OF PLURIPOTENT AUTOLOGOUS STEM CELLS FROM ORAL MUCOSA

RAMOT AT TEL-AVIV UNIVERS...

1. A culture comprising pluripotent stem cells that originated in the lamina propria of the oral mucosa, in an in vitro culture
medium that ensures growth in vitro without production of differentiated progeny cells at the expense of the pluripotent stem
cells, wherein said stem cells each display all of the markers Nestin, p75, Sox2, Oct4 and Nanog.
US Pat. No. 9,249,522

ELECTROPHORETIC DEPOSITION OF THIN FILM BATTERIES

Ramot at Tel-Aviv Univers...

1. A method, comprising the steps of:
a) forming on a substrate a first polarity thin film battery electrode comprising a first active material; and
b) electrophoretically depositing on the first polarity battery electrode a glass-ceramic material to serve as a battery separator.

US Pat. No. 10,190,940

SPECTRALLY EFFICIENT OPTICAL FREQUENCY-DOMAIN REFLECTOMETRY USING I/Q DETECTION

DSIT Solutions Ltd., Giv...

1. A system for fiber-optic reflectometry, the system comprising:an optical source, which is configured to generate an optical interrogation signal that is transmitted into an optical fiber;
a beat detection module, which is configured to receive from the optical fiber an optical backscattering signal in response to the optical interrogation signal, and to mix the optical backscattering signal with a reference replica of the optical interrogation signal using In-phase/Quadrature (I/Q) mixing, so as to produce a complex beat signal having In-phase (I) and Quadrature (Q) components; and
a processor, which is configured to sense one or more events affecting the optical fiber by analyzing the I and Q components of the complex beat signal, including defining in the complex beat signal at least:
a first time interval, during which an instantaneous frequency of the optical backscattering signal is guaranteed to be lower than the instantaneous frequency of the reference replica; and
a second time interval, during which the instantaneous frequency of the optical backscattering signal is guaranteed to be higher than the instantaneous frequency of the reference replica.

US Pat. No. 9,574,868

PORTABLE INTERFEROMETRIC DEVICE

RAMOT AT TEL-AVIV UNIVERS...

1. An interferometric device comprising a light directing optical arrangement for directing light to an optical detector,
wherein the light directing optical arrangement is configured for defining first and second substantially overlapping optical
paths towards said optical detector, the light directing optical arrangement comprising:
a beam splitter/combiner unit for receiving an input beam having an amplitude and phase modulation and splitting said input
beam into first and second light beams;

first and second reflective surfaces accommodated in the first and second optical paths of said first and second light beams
to direct said first and second light beams back to said beam splitter/combiner that directs the combined beam to the detector,
wherein one of said first and second reflective surfaces comprises a retro-reflector configured and operable to reflect said
first light beam and shift a Fourier plane center of the reflected light beam, so that an off-axis angle is created between
said first and second light beams, wherein said retro-reflector is positioned in the Fourier plane of the reflected light
beam; and

a spatial filter comprising a pinhole accommodated in front of one of the first and second reflective surfaces and a Fourier
optics assembly comprising two lenses, one lens being in a 4f configuration with respect to the other;

wherein the beam splitter/combiner unit directs one of the first and second light beams through said spatial filter to enable
amplitude and phase demodulation thereof and formation of a reference beam with respect to the other modulated beam.

US Pat. No. 9,237,750

ORNIDAZOLE AND RELATED COMPOUNDS FOR USE AS HERBICIDES

RAMOT AT TEL-AVIV UNIVERS...

1. A method of inhibiting the growth of a photosynthetic organism, comprises applying to the photosynthetic organism and/or
to its habitat where the photosynthetic organism is growing or will grow a compound or a plurality of compounds having the
general formula I, or a salt thereof:

wherein:
R1 is H, halogen or C1-C4 alkyl;

one of R2 and R3 is H or halogen and the other is NO2; and

X is a halogen;
thereby inhibiting the growth of said photosynthetic organism, and
wherein said photosynthetic organism is selected from the group consisting of plants, algae and cyanobacteria.

US Pat. No. 9,236,504

SYSTEM AND METHOD FOR CONTROLLING A GROUP OF PHOTOVOLTAIC GENERATORS

RAMOT AT TEL-AVIV UNIVERS...

1. A system for controlling a group of photovoltaic energy generators, the system comprising a power feedback circuit configured
to provide, to a junction that is coupled to a component of a first photovoltaic energy generator (PEG), power generated by
multiple PEGs of the group of photovoltaic energy generators (PRGs) such as to increase the power generated from the PEGs;
wherein the group of PEGs comprises the first PEG and a second PEG; wherein each PEG of the group of PEGS comprises a photovoltaic
cell.

US Pat. No. 10,031,267

OPTICAL ELEMENT HAVING TWO PHASE MASKS

Ramot at Tel-Aviv Univers...

1. An optical element, comprising:a first phase shift mask formed on a first optical material and constituted to generate a positive phase shift, and
a second phase shift mask formed on a second optical material and constituted to generate a negative phase shift,
wherein said first mask forms an etched pattern of depth h1 in said first optical material, and said second mask forms a relief pattern of height h2 on said second optical material, and wherein a difference between a refractive index characterizing said first optical material and a refractive index characterizing said second optical material is at least 0.1.
US Pat. No. 9,717,761

STEM CELL-DERIVED NEURAL CELLS FOR CELL THERAPY IN NEUROLOGICAL DISORDERS

RAMOT AT TEL-AVIV UNIVERS...

1. A method for inducing selective differentiation of oral mucosa stem cells (OMSC) into neuron-supporting glial cells, comprising:
(a) obtaining oral mucosa stem cells (OMSC) from oral mucosa;
(b) incubating the OMSC of (a) in a pre-differentiating medium, comprising N-2 supplement, basic fibroblast growth factor
2 (bFGF) and epidermal growth factor (EGF); and

(c) after incubation of the OMSC in (b), replacing the pre-differentiation medium of (b) with a differentiating medium comprising
dibutyryl cyclic adenosine monophosphate (dbcAMP), IBMX (3-Isobutyl-1-methylxanthine), neuregulin, and platelet-derived growth
factor (PDGF) and incubating the OMSC from (b) in the differentiation medium to selectively differentiate OMSC into neuron-supporting
glial cells secreting neurotrophic factors.

US Pat. No. 9,574,210

CELL-TARGETING NANOPARTICLES COMPRISING POLYNUCLEOTIDE AGENTS AND USES THEREOF

RAMOT AT TEL-AVIV UNIVERS...

1. A particle for delivery of a polynucleotide to a target cell, generated according to a method comprising:
(a) contacting the polynucleotide with a composition comprising 1,2-Dilauroyl-sn-Glicero-3-Phosphoethanolamine (DLPE) and
1,2-Dilauroyl-sn-Glicero-3-Glycerol (DLPG), wherein said DLPE and DLPG condense the polynucleotide by electrostatic interactions
to generate a complex, and wherein said DLPE and DLPG are not comprised in a liposome; and

(b) covalently binding said complex to a glycosaminoglycan targeting moiety at a pH equal to or below about 4.5, thereby generating
the particle for delivery of the polynucleotide agent to the target cell.

US Pat. No. 9,516,621

METHOD AND SYSTEM FOR ESTIMATING POSITION

Ramot at Tel-Aviv Univers...

1. A method of estimating a position of an object, comprising:
receiving a plurality of signals transmitted between each of a respective plurality of reference stations of known position
and the object;

for each received signal: processing said signal using a matrix featuring a characteristic power delay profile and a characteristic
signal waveform to provide a processed signal, and partitioning said signal into at least a first segment containing noise
and a second segment containing at least a multipath signal corresponding to a plurality of paths between the object and a
respective reference station; and

calculating a direct estimate of the position of the object based, at least in part, on said processed signals and on said
segments.

US Pat. No. 9,486,467

METHOD OF TREATING COLORECTAL CANCER THAT EXPRESSES A MUTATED APC GENE BY ADMINISTERING ERYTHROMYCIN OR TYLOSIN

RAMOT AT TEL-AVIV UNIVERS...

1. A method for treating a human subject having colorectal cancer that expresses a mutated APC gene that contains a premature
stop codon caused by a nonsense mutation, comprising treating the human subject by administering to the human subject, as
active agent, a therapeutically effective amount of tylosin or erythromycin, or a pharmaceutically acceptable salt or prodrug
of tylosin or erythromycin, wherein said treating excludes preventing the colorectal cancer.

US Pat. No. 9,283,279

TARGETED POLYMERIC CONJUGATES AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. A conjugate having the structure:

wherein n is an integer that ranges from 10 to 1000.

US Pat. No. 9,823,126

APPARATUS AND METHOD FOR SNAPSHOT SPECTRAL IMAGING

Ramot at Tel-Aviv Univers...

1. An apparatus for obtaining a plurality of spectral images of a source object in a snapshot, comprising:
a) an imaging section of a digital camera that includes a lens and a pixelated image sensor, the imaging section configured
to obtain a diffused and dispersed (DD) snapshot image Y; and

b) a digital processor configured to perform two-dimensional compressed sensing spectral cube reconstruction (2D CS-SCR) from
snapshot image Y by applying a 2D framelet transform separately to arrays representing different wavebands of spectral cube
data derived from snapshot image Y, thereby providing images of the source object in a plurality of spectral bands.

US Pat. No. 9,479,191

LINEARIZED OPTICAL DIGITAL-TO-ANALOG MODULATOR

Ramot at Tel-Aviv Univers...

1. A system for converting digital data into a modulated optical signal, comprising:
(a) an electrically controllable device having M actuating electrodes for actuating said device, the device providing an optical
signal that is modulated in response to binary voltages applied to the actuating electrodes; and

(b) an electrode actuating device having an electronic input for receiving digital input data words having a plurality of
bits, and at least one digital-to-digital converter being enabled to provide a mapping of the input data words to binary actuation
vectors of M bits and supplying the binary actuation vectors as M bits of binary actuation voltages to the M actuating electrodes,
where M>N, N representing a number of bits in each input data word;

wherein the at least one digital-to-digital converter is enabled to map each digital input data word to a binary actuation
vector of M bits by selecting a binary actuation vector from a subset of a total 2M possible binary actuation vectors of M bits available to represent each of the received input data words of N bits.

US Pat. No. 10,088,418

METHOD AND SYSTEM FOR MICROSCOPY

Ramot at Tel-Aviv Univers...

29. A system of microscopy, comprising:an optical system configured for directing a pulse of a pump optical beam to form an optical spot on a substance;
a measuring system configured for measuring changes in a temperature-dependent or photo-excited property of said substance; and
an analysis system configured for analyzing said measured changes to distinguish between information pertaining to said property at a portion of said spot, and information pertaining to said property at other portions of said spot;
wherein a largest diameter of said portion of said spot is less than a central wavelength of said pump optical beam.

US Pat. No. 9,833,187

DETECTION, DIAGNOSIS AND MONITORING OF OSTEOPOROSIS BY A PHOTO-ACOUSTIC METHOD

Ramot at Tel-Aviv Univers...

1. An apparatus for examining bone in vivo, comprising:
a laser source configured to produce a laser beam;
an acousto-optic modulator, configured to modulate said laser beam at acoustic frequencies being frequencies that are able
to give rise to acoustic waves;

a waveform generator configured to drive said acousto-optic modulator with a modulation signal at a range of said acoustic
frequencies, thereby to produce a modulated multiple frequency acousto-optic beam able to cause excitation at a plurality
of frequencies;

a spectrum analyzer, configured to analyze received signals from said bone, said received signals including signals resulting
from acoustic waves traveling within said bone caused by said modulated multiple frequency acousto-optic beam, wherein said
spectrum analyzer is further configured to analyze said received signals of said modulated multiple frequency acousto-optic
beam at optical wavelengths and acoustic frequencies, and to scan said optical wavelengths and acoustic frequencies to map
a bone transfer function, and further to analyze amplitude and phase with variation of said frequency to determine a speed
of sound dispersion and a broadband ultrasonic attenuation, said spectrum analyzer being further configured to determine a
mineral density and a bone quality for said bone from said analyzing.

US Pat. No. 9,816,077

USE OF INTEGRASE FOR TARGETED GENE EXPRESSION

RAMOT AT TEL-AVIV UNIVERS...

1. A composition for transient expression of an exogenous protein of interest specifically in a human cancer cell, comprising
at least one nucleic acid molecule, wherein said at least one nucleic acid molecule comprises:
(a) a first nucleotide sequence encoding an exogenous HK022 integrase and including a first tissue specific promoter sequence
operably linked to said sequence encoding said exogenous HK022 integrase, said first tissue specific promoter being capable
of activating expression specifically in a human cancer cell and being selected from the group consisting of hTERT, DF3/MUC1,
HE4, and MSLN promoters;

(b) a second nucleotide sequence encoding the exogenous protein of interest and including a second tissue specific promoter
sequence operably linked to said sequence encoding the exogenous protein of interest, said second tissue specific promoter
being capable of activating expression specifically in a human cancer cell and being selected from the group consisting of
hTERT, DF3/MUC1, HE4, and MSLN promoters; and

(c) a third nucleotide sequence comprising a transcription terminator, an attL sequence and an attR sequence, said transcription
terminator being located between the attL and attR sequences, said third nucleotide sequence being located upstream of the
sequence encoding the exogenous protein of interest and between said sequence encoding the exogenous protein of interest and
the second tissue specific promoter sequence.

US Pat. No. 9,773,669

METHOD OF FABRICATING A NANORIBBON AND APPLICATIONS THEREOF

Ramot at Tel-Aviv Univers...

1. A method of fabricating a nanostructure, comprising:
forming an elongated tubular nanostructure having a core-shell structure on a generally planar substrate such that a longitudinal
axis is generally parallel to said substrate;

forming on said substrate a protective layer having a thickness less than a diameter of said tubular nanostructure, thereby
partially burying said tubular nanostructure in said protective layer;

generating conditions for said tubular nanostructure to unwrap, by etching an unburied portion of said tubular nanostructure
and removing said protective layer; and

selectively removing said core following said removal of said protective layer;
thereby forming a non-tubular nanostructure.

US Pat. No. 9,718,538

SYNCHRONIZATION OF FLUIDIC ACTUATORS

Ramot at Tel-Aviv Univers...

1. A fluidic system, comprising:
a plurality of fluidic oscillatory actuators, each actuator having a joining channel, a pair of control ports at opposite
sides of said joining channel, and a feedback conduit directly connecting said control ports of said pair to each other; and

a plurality of external synchronization conduits connecting at least two of said actuators, wherein for at least two of said
external synchronization conduits, each conduit directly connects control ports that are on the same side of a respective
joining channel.

US Pat. No. 9,632,158

MRI IMAGING AND CONTRAST METHOD

Ramot at Tel-Aviv Univers...

1. A method for calculating an image which, in a subject whose tissue has already been or is already being subject to a thermal
ablation procedure, distinguishes between thermally damaged tissue and non-thermally-damaged tissue, comprising:
a) using an MRI scanner, exposing tissues to a first set of MR pulses which result in a proton magnetization exchange between
water molecules and macromolecules of said tissues, followed by applying a first imaging sequence, said first set of MR pulses
comprising a first pulse sequence which comprises a first pulse, a second pulse, and a third pulse, a first time interval
between said first and said second pulses of said first pulse sequence being sufficiently long to allow relaxation of transverse
magnetization of said macromolecules and sufficiently short to prevent significant relaxation of transverse magnetization
of said water molecules, and a second time interval between said second pulse and said third pulse of said first pulse sequence
being sufficiently long to allow substantial transfer of magnetization from said water molecules to said macromolecules;

b) using the MRI scanner, exposing said tissues to a second set of MR pulses, which second set results in substantially less
proton magnetization exchange between water molecules and macromolecules of said tissue, followed by applying a second imaging
sequence, said second set of MR pulses comprising a second pulse sequence which comprises a first pulse, a second pulse, and
third pulse;

c) calculating an image representing spatially differentiated differences between intensities of signals detected from said
first and from said second imaging sequences, using a data processor, comprising calculating a difference between a first
signal generated in response to said first pulse sequence and a second signal generated in response to said second pulse sequence;
and

d) using the image to measure physical changes brought about in the tissue by the thermal ablation procedure;said calculated image distinguishing between thermally damaged tissue and non-thermally damaged tissue based on differences
between proton magnetization exchange rates of thermally damaged tissue and of non-thermally damaged tissue.

US Pat. No. 9,953,427

METHOD AND SYSTEM FOR PROCESSING AN IMAGE

Ramot at Tel-Aviv Univers...

1. A method of processing an image, comprising:decomposing the image into a plurality of channels, each being characterized by a different depth-of-field, and storing said decomposed image in a memory;
accessing, by a digital image processor, a non-transitory computer readable medium storing an in-focus dictionary defined over a plurality of dictionary atoms, and an out-of-focus dictionary defined over a plurality of sets of dictionary atoms, each set corresponding to a different out-of-focus condition;
computing, by said image processor, at least one sparse representation of said decomposed image over said dictionaries, and storing said at least one sparse representation in a memory, wherein said image is divided into a plurality of patches, and wherein said computing is performed by expressing each patch as a combination of atoms of a sub-dictionary of said out-of-focus dictionary; and
generating by said image processor a processed image using said sparse representation, and displaying said processed image on a display device.

US Pat. No. 9,882,223

CATALYSTS AND ELECTRODES FOR FUEL CELLS

RAMOT AT TEL-AVIV UNIVERS...

1. An anode comprising a support and a catalyst dispersed thereon, wherein said catalyst comprises at least one precious metal
selected from Pt, Ru, Re, Pd and Ir, wherein said catalyst composition catalyzes, in the presence of a halogen ion or a mixture
of halogen ions, (a) a hydrogen oxidation charging reaction (HOR) and a hydrogen evolution discharging reaction (HER) in a
regenerative fuel cell and/or (b) a reaction between a fuel and an oxidant to generate an electric current; wherein said catalyst
composition is selected from the group consisting of (i) Ir, Ru, Pd, Pt, Re, and mixtures thereof, and alloys thereof; (ii)
alloys of Ir, Ru, Pd, Pt and Re with one or more transition metals selected from Cr, Mo, Ta, Ni, Co and Fe; (iii) (PtRe) in
combination with M, (PdRe) in combination with M, and (PtM) in combination with Ir, wherein M is a precious metal selected
from Pt, Ru, Re, Pd and Ir, or a transition metal; and (iv) PtRe, PdRe, PtIr, PdIr, PtCr, PtRu, Pt in combination with Ir
in combination with Ru, PtReCo, PtReMo, Ir in combination with Ru, (PtRe) in combination with Ir, (PtRu) in combination with
Ir, (PtReMo) in combination with Ir, and (PtReCo) in combination with Ir; wherein the catalyst composition is dispersed on
the anode that is part of a membrane electrode assembly (MEA) in a regenerative fuel cell; wherein the regenerative fuel cell
has a nanoporous proton conducting membrane capable of exhibiting operational stability in the regenerative fuel cell, having
pores with a diameter size which is essentially smaller than 50 nm, and comprises: (i) 5% to 60% by volume of an electrically
nonconductive inorganic powder having acid absorption capacity, wherein the powder comprising essentially nanosize particles;
(ii) 5% to 50% by volume of a polymeric binder that is chemically compatible with acid, oxygen and fuel; and (iii) 10 to 90%
by volume of an acid or aqueous acid solution.
US Pat. No. 9,598,478

PEPTIDES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Ramot at Tel-Aviv Univers...

1. A method of treating Huntington's Disease (HD) in a subject in need thereof, the method comprising administering to the
subject a therapeutically effective amount of an isolated peptide comprising a Huntingtin (Htt) amino acid sequence being
no longer than 15 amino acids which comprises the sequence as set forth in SEQ ID NO: 2, thereby treating the Huntington's
Disease (HD).
US Pat. No. 10,183,072

TILAPIA VIRUS AND USES THEREOF

KIMRON VETERINARY INSTITU...

1. An isolated nucleic acid having a sequence selected from the group consisting of SEQ ID NOs: 1-11, or complementary to a sequence selected from the group consisting of SEQ ID NOs: 1-11, wherein the nucleic acid is cDNA.
US Pat. No. 10,118,943

COMPOUNDS AND METHODS FOR INHIBITING CELL DEATH

Ramot at Tel-Aviv Univers...

1. An isolated peptide consisting of the amino acid sequence of SKIP (SEQ ID NO: 6), which is acetylated at the N-terminus and amidated at the C-terminus in an effective amount to inhibit cell death or increase cell plasticity.

US Pat. No. 10,033,465

LINEARIZED OPTICAL DIGITAL-TO-ANALOG MODULATOR

Ramot at Tel-Aviv Univers...

1. A method for converting digital electrical data into modulated optical streams, said method comprisinginputting into an optical modulator N bits of digital data in parallel, N being larger than 1;
mapping a set of N input values corresponding to said N bits of digital data to a vector of M voltage values where M is equal to or larger than N;
driving at least M electrodes of the optical modulator, enabled to pulse modulate at least an input optical stream, responsively to the M voltage values, to provide at least a pulse modulated output optical stream.

US Pat. No. 9,900,562

SYSTEM AND METHOD FOR LIGHT-FIELD IMAGING

RAMOT AT TEL-AVIV UNIVERS...

1. A light-field imaging system comprising:
a detector unit comprising an array of detector elements and configured and operable to generate image data indicative of
light collected by the detector elements,

an imaging lens unit configured for collecting input light from a scene and generating a corresponding image of the scene
on the detector array to produce the image data,

a polychromatic patterned filter defining a predetermined sensing matrix indicative of a configuration of the polychromatic
patterned filter and located in an optical path of the collected light, being at an intermediate plane between the lens unit
and the array of detector elements, the polychromatic patterned filter providing mixing of light properties between the detector
elements, and

a control unit configured and operable for receiving and processing the image data from the array of detector elements, said
image data being indicative of the mixing of light properties between the detector elements corresponding to the sensing matrix
of the polychromatic patterned filter, applying data about said sensing matrix to the received image data thereby providing
a reconstructed polychromatic light-field image of said scene,

wherein said control unit comprises a processing utility, said processing utility comprises a data optimizing module configured
and operable to iteratively determine data indicative of the reconstructed image data in accordance with data about the polychromatic
patterned filter to thereby determine a reconstructed polychromatic light-field data of said scene.

US Pat. No. 9,790,254

SELF-ASSEMBLED PEPTIDE NANOSTRUCTURES

Ramot at Tel-Aviv Univers...

1. A composition comprising a plurality of tubular nanostructures, wherein at least 80% of said nanostructures are characterized
by a length smaller than 10 microns, each of said nanostructures being formed of a plurality of aromatic dipeptides, said
plurality of aromatic dipeptides comprising at least two different types of aromatic dipeptides, at least one type of said
aromatic dipeptides being an end-capping modified aromatic dipeptide and at least one type of aromatic dipeptides being a
non-modified aromatic dipeptide,
wherein each of said non-modified aromatic dipeptides is a phenylalanine-phenylalanine dipeptide and each of said end-capping
modified dipeptides is an N-terminus modified peptide, said end capping moiety being tert-butoxycarbonyl (Boc),

wherein a molar ratio of said at least two types of aromatic dipeptides in said plurality of aromatic dipeptides is such that
provides tubular nanostructures characterized by said length.

US Pat. No. 9,750,817

AMPHOTERICIN B DERIVATIVES

RAMOT AT TEL-AVIV UNIVERS...

1. A compound according to formula [I]:

wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble PEG polymer having p PEG monomers, wherein p is from 6 to 40, and pharmaceutically acceptable salts, solvates,
hydrates, and diastereomers of the compound of Formula [I].

US Pat. No. 9,630,989

DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION

Ramot at Tel-Aviv Univers...

1. A method of treating an amyloid-associated disease or disorder in a subject in need thereof, the method comprising administering
to the subject a therapeutically effective amount a dipeptide analog comprising a tryptophan (Trp) moiety coupled to a beta-sheet
breaker moiety, with the proviso that either said Trp moiety is not Trp or said beta-sheet breaker moiety is not ?-aminoisobutyric
acid (Aib) or that said dipeptide analog is not an ester of a Trp-Aib dipeptide,
wherein said beta sheet breaker moiety has a chemical structure selected from the group consisting of:
and wherein said Trp moiety has a chemical structure selected from the group consisting of:

thereby treating the disease or disorder.

US Pat. No. 9,331,342

ELECTROCHEMICAL SYSTEMS AND METHODS OF OPERATING SAME

RAMOT AT TEL-AVIV UNIVERS...

1. An electrochemical system comprising:
(a) an energy storage system comprising a regenerative fuel cell system which generates electrical energy and reactant product
from fuel and oxidizer in a fuel cell mode, and which generates the fuel and oxidant from the reactant product and electrical
energy in an electrolysis mode; at least one fuel storage vessel in fluid communication with said regenerative fuel cell system;
and at least one reactant product storage vessel in fluid communication with said regenerative fuel cell system;

wherein the regenerative fuel cell system comprises one or more stacks of regenerative fuel cells, an electrolyte feed inlet
connected to one or more stacks of regenerative fuel cells, an electrolyte feed line extending from the electrolyte feed inlet
to at least one electrolyte holding vessel, an electrolyte discharge outlet connected to one or more stacks of regenerative
fuel cells and a electrolyte discharge line extending from the electrolyte discharge outlet to the at least one electrolyte
holding vessel;

wherein at least a portion of the electrolyte feed line adjacent to the electrolyte feed inlet has a coiled configuration,
and at least a portion of the electrolyte discharge line adjacent to the electrolyte discharge outlet opening has a coiled
configuration;

said regenerative fuel cells comprising a housing; a nanoporous proton conducting membrane having a first surface and a second
surface, disposed in said housing to partition it into an anode side and a cathode side; an anode formed on said first surface
so as to connect said first surface to the anode side; a cathode formed on said second surface so as to connect said second
surface to the cathode side; said anode comprising a support and a catalyst dispersed thereon; said cathode comprising a support,
or a support and a catalyst dispersed thereon; wherein the catalyst dispersed on said anode and the catalyst dispersed on
said cathode are the same or different and are capable of catalyzing, in the presence of an acid or a mixture of acids, or
a halogen ion or a mixture of halogen ions, a charging reaction in electrolysis mode and a discharging reaction in fuel cell
mode in said regenerative fuel cells; and

an energy source electrically connected to the regenerative fuel cell system to provide electrical energy to the regenerative
fuel cell system operating in the electrolysis mode; or

(b) a regenerative fuel cell system which generates electrical energy and reactant product from fuel and oxidizer in a fuel
cell mode, and which generates the fuel and oxidant from the reactant product and electrical energy in an electrolysis mode;

wherein the regenerative fuel cell system comprises one or more stacks of regenerative fuel cells, an electrolyte feed inlet
connected to one or more stacks of regenerative fuel cells, an electrolyte feed line extending from the electrolyte feed inlet
to at least one electrolyte holding vessel, an electrolyte discharge outlet connected to one or more stacks of regenerative
fuel cells and an electrolyte discharge line extending from the electrolyte discharge outlet to the at least one electrolyte
holding vessel;

wherein at least a portion of the electrolyte feed line adjacent to the electrolyte feed inlet has a coiled configuration,
and at least a portion of the electrolyte discharge line adjacent to the electrolyte discharge outlet opening has a coiled
configuration;

said regenerative fuel cells comprising a housing; a nanoporous proton conducting membrane having a first surface and a second
surface, disposed in said housing to partition it into an anode side and a cathode side; an anode formed on said first surface
so as to connect said first surface to the anode side; a cathode formed on said second surface so as to connect said second
surface to the cathode side; said anode comprising a support and a catalyst dispersed thereon; said cathode comprising a support,
or a support and a catalyst dispersed thereon; wherein the catalyst dispersed on said anode and the catalyst dispersed on
said cathode are the same or different and are capable of catalyzing, in the presence of an acid or a mixture of acids, or
a halogen ion or a mixture of halogen ions, a charging reaction in electrolysis mode and a discharging reaction in fuel cell
mode in said regenerative fuel cells;

a reactant product delivery or storage device in fluid communication with said regenerative fuel cell system; the reactant
product delivery device providing excess reactant product to the regenerative fuel cell system operating in the electrolysis
mode, in addition to or instead of the reactant product generated by the regenerative fuel cell system in the fuel cell mode,
such that fuel in excess of fuel required to operate the regenerative fuel cell system in the fuel cell mode is generated
in the electrolysis mode; the reactant product storage device storing excess reactant product to be provided to the regenerative
fuel cell system operating in the electrolysis mode, in addition to the reactant product generated by the regenerative fuel
cell system operating in the fuel cell mode; and

a product/fuel storage device in fluid communication with said regenerative fuel cell system; the product/fuel storage device
storing products and excess fuel from the charging reaction in electrolysis mode and the discharging reaction in fuel cell
mode.

US Pat. No. 9,976,149

MODIFIED LISTERIA BACTERIA AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. A Listeria monocytogenes bacterium comprising a first mutation in the multidrug resistance transporter M (MdrM) gene having the gene ID: 12553832, a second mutation in the multidrug resistance transporter T (MdrT) gene having the gene ID: 12554851 and at least one additional mutation in a multidrug resistance transporter gene selected from the group consisting of MdrA gene having the gene ID: 12552738, MdrB gene having the gene ID: 12555124, MdrC gene having the gene ID: 12555097, MdrE gene having the gene ID: 12555105, wherein said Listeria monocytogenes bacterium which comprises said first mutation, said second mutation and said at least one additional mutation decreases interferon-? production in macrophages as compared to wild-type Listeria monocytogenes bacterium as measured by PCR.

US Pat. No. 9,553,315

DIRECT LIQUID FUEL CELL HAVING AMMONIA BORANE OR DERIVATIVES THEREOF AS FUEL

Ramot at Tel-Aviv Univers...

1. A fuel cell system comprising:
an anode compartment, a cathode compartment, and a separator interposed between said cathode and said anode compartments,
wherein an anode of said anode compartment comprises a catalyst layer consisting of a metal selected from the group consisting
of copper, gold, silver, and an alloy of at least one of copper, silver and gold, said catalyst layer being devoid of a platinum
group metal,

the fuel cell system being identified as operable by contacting said anode compartment with a fuel composition which comprises
a compound having the formula R1R2R3N—BR4R5R6 as fuel, contacting said cathode compartment with an oxidant, and electrochemically reacting said fuel composition and said
oxidant,

wherein each of R1-R6 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteroalicyclic, alkoxy, and amine,
provided that at least one of R4, R5 and R6 is hydrogen.

US Pat. No. 9,464,052

POTASSIUM ION CHANNEL MODULATORS AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. A compound of formula (I) or a pharmacologically acceptable salt or pro-drug thereof wherein:

Ar1 and Ar2 are each phenyl;

a is 1;
R1 is halogen;

b is an integer of from 0 to 3;
R2 is selected from the group consisting of alkyl having from 1 to 3 carbon atoms, halogen, haloalkyl having from 1 to 3 carbon
atoms, alkoxy having from 1 to 3 carbon atoms, haloalkoxy having from 1 to 3 carbon atoms, carboxyl, amino, hydroxyl and cyano,
and where b is greater than 1, each substituent R2 may be the same or different;

V is (CR3aR3b)pCON(R3b)X, wherein said group is in the 3- (meta) or 4- (para) position with respect to the substituent Z;

W is NR4a, wherein R4a is selected from the group consisting of hydrogen, alkyl having from 1 to 3 carbon atoms and phenyl; X is a substituent selected
from the group consisting of hydroxyalkyl having from 1 to 4 carbon atoms, polyalkylene glycol residue of general formula:

HO—[(CR6aR6b)c1—O—(CR6cR6d)c2]c3—

wherein c1 and c2 are the same or different and each is an integer of from 1 to 3, c3 is an integer of from 1 to 10 and R6a,R6b R6c and R6d may be the same or different and each is a hydrogen or an alkyl having from 1 to 4 carbon atoms, alkoxyalkyl comprising an
alkyl having from 1 to 4 carbon atoms that is substituted with at least one alkoxy having from 1 to 4 carbon atoms, carboxyalkyl
comprising an alkyl having from 1 to 4 carbon atoms that is substituted with at least one carboxy, carboxyalkyl comprising
alkyl having from 1 to 4 carbon atoms which are substituted with at least one carboxy and alkoxycarbonylalkyl comprising alkyl
having from 1 to 4 carbon atoms which are substituted with at least one alkoxycarbonyl having from 2 to 5 carbon atoms;

Y and Z are each a group of formula (CR5aR5b)n1 wherein each n1 is 0;

R3a and R3b are the same or different and each is selected from the group consisting of hydrogen and alkyl; and

p is an integer of from 0 to 2.
US Pat. No. 10,174,343

LACTIC ACID BACTERIA FOR THE PRODUCTION OF ETHANOL FROM BIOMASS MATERIAL

Yeda Research and Develop...

1. A bacterial culture comprising a biomass composition and a population of lactic acid bacteria which comprises:(i) a first population of lactic acid bacteria which has been genetically modified to express a secreted cellulase;
(ii) a second population of lactic acid bacteria which has been genetically modified to express a secreted xylanase, wherein the ratio of the first population: second population is selected such that the specific activity of cellulase: xylanase in the culture is greater than 4:1 or less than 1:4; and
(iii) a third population of lactic acid bacteria which has been genetically modified to produce ethanol.

US Pat. No. 9,785,655

DYNAMIC MAPS FOR EXPLORING AND BROWSING OF IMAGES

Ramot at Tel-Aviv Univers...

1. A method of mapping a collection of items of high dimensional data, said high dimensional data being any of images or text
documents or three dimensional objects or higher than three dimensional objects, onto a navigable grid for browsing, said
browsing being via a user interface: the method comprising:
obtaining for respective items of said collection a list of nearest neighbor items and scores indicating degrees of similarity
between a respective item and each of said listed nearest neighbors, said scores being based on item content;

placing a first item of said collection on a first cell within said navigable grid;
from a respective list of nearest neighbor items of said first item of said collection, selecting items from said list to
place on a given cell, said items being selected to maximize a compatibility score with items already placed on neighboring
cells of said given cell of said grid, said maximizing using respective similarity scores; and

as a user pans across said grid in a pan direction to reveal additional cells, taking an item placed in said pan direction
and obtaining a further list of nearest neighbor items for said item placed in said pan direction and placing items of said
list on neighboring cells of said placed item according to scores indicating degrees of similarity between said items of said
list and respectively placed neighboring items, said scores being based on item content, and continuing to obtain new lists
and place further items on said grid at cells revealed by said panning, by said maximizing of respective compatibility scores,
until all cells visible to a user are filled with items.

US Pat. No. 9,655,933

FILAMENTOUS BACTERIOPHAGE AS AN ANGIOGENESIS MODULATOR

RAMOT AT TEL-AVIV UNIVERS...

1. A method for treating cancer, comprising administering to a subject in need thereof an effective amount of a filamentous
bacteriophage carrying bacterial Lipopolysaccharide (LPS) endotoxin on its surface in the form of a bacteriophage-LPS endotoxin
complex, with the proviso that the filamentous bacteriophage does not display an antibody or a tumor specific peptide.

US Pat. No. 9,528,830

ANGULAR RATE SENSOR

RAMOT AT TEL-AVIV UNIVERS...

1. A rotation sensing device comprising a structure comprising:
a proof mass arrangement comprising at least one pair of proof masses spaced-apart from one another along a first axis;
a suspension assembly comprising flexible suspension beams having a main axis deformable between their substantially straight
and curved states, the suspension assembly coupling the proof masses to an anchor assembly, while allowing a drive-mode oscillatory
movement of the proof masses at least along a second axis substantially perpendicular to the main axis of the beams;

an actuation mechanism configured and operable to apply an electrostatic force to the proof masses, causing deformation of
the beams and periodic variation of the beams' stiffness, to thereby parametrically excite the drive-mode oscillatory movement
of the proof masses in opposite directions along said second axis, thereby generating a sense-mode oscillatory movement of
the proof masses during the rotation of the device about at least one rotation axis perpendicular to said second axis, said
sense-mode movement being indicative of a rate of the rotation.

US Pat. No. 10,465,004

FRIZZLED RECEPTOR ANTIBODIES FOR TREATMENT OF CANCER

Tel HaShomer Medical Rese...

1. A method for treating a tumor characterized by elevated expression of a Frizzled7 receptor in a subject, said method comprising the step of administering a therapeutically effective dose of an isolated antibody or antigen-binding portion thereof that binds to a Frizzled7 receptor, wherein the antibody binds to the cytoplasmic portion of said receptor and wherein the antibody has complementarity determining regions (CDRs) of the antibody produced by the hybridoma cell line 288-1 deposited in the American Type Culture Collection, Manassas, Va., USA, under the Registration Number PTA-123746; or the antibody produced by the hybridoma cell line 288-5 deposited in the American Type Culture Collection, Manassas, Va., USA, under the Registration Number PTA-123744.

US Pat. No. 10,275,680

MAGNETIC RESONANCE MAPS FOR ANALYZING TISSUE

Tel HaShomer Medical Rese...

1. Apparatus for analyzing magnetic resonance images, comprising:an input circuit configured for receiving a first and a second Magnetic Resonance Imaging (MRI) scan of a tissue at a beginning and end of a predetermined time interval post contrast agent administration, wherein said tissue is a brain of a subject and wherein said predetermined time interval is at least fifty minutes;
a memory for storing said first and said second MRI scans;
an image processor having a circuit configured for subtracting said first and said second MRI scans from one another to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which contrast clearance is faster than contrast accumulation; and
an output circuit configured for converting said scans to a displayed subtraction map on which distributions of said two primary populations are distinguished,
wherein said fast population is displayed as a tumor that is selected from a group consisting of a tumor demonstrating hyper cellularity, a tumor demonstrating mitoses, a tumor demonstrating high Ki67, a tumor demonstrating pseudo-palisading necrosis, and any combination thereof, and
wherein said slow population is displayed as a non-tumoral tissue region selected from a group consisting of (i) treatment effect, (ii) pseudo-progression, (iii) radiation-necrosis, (iv) inflammation, (v) post-surgical changes, (vi) tumor necrosis, and any combination thereof.

US Pat. No. 10,175,246

METHOD AND SYSTEM FOR DETECTING A TARGET WITHIN A POPULATION OF MOLECULES

Ramot at Tel-Aviv Univers...

1. A system for analysis of a population of molecules, wherein the population of molecules contains a plurality of probe molecules including at least one labeled probe molecule, wherein the plurality of probe molecules is in contact with a population of molecules potentially containing a target comprising a plurality of target molecules, wherein at least some of the plurality of probe molecules selectively bind to at least some target molecules, so that the at least one labeled probe molecule is bound to at least a portion of the target, said system comprising:a vessel adapted to contain the population of molecules;
a fluorescent excitation source adapted to direct an excitation beam in a first direction through said vessel, the beam configured to cause at the least one labeled probe molecule to emit a probe specific signal;
a detector adapted to detect said probe specific signal and produce a detection output accordingly;
a signal modulator configured to perform a preferential modulation to at least one of the probe specific signal and said detection output, wherein said signal modulator is configured to create a cyclic magnetic field gradient using two electromagnetic poles driven with a frequency of cycling of current between the two poles, wherein said poles are configured to achieve an increase in said magnetic field gradient outside said poles, wherein said magnetic field gradient is configured to increase a local concentration of probe molecules with bound target molecules to form a cloud of condensed particles, wherein said magnetic field gradient causes the cloud of condensed target molecules with bound magnetic particles to cross a path of the fluorescence excitation energy beam as the cloud of condensed target molecules with bound magnetic particles crosses between said electromagnetic poles in a cyclical manner, wherein said detection output includes data regarding at least one of the following:
at least one of said at least one labeled probe molecule bound to at least a portion of the target; and
the cloud of condensed particles; and
wherein the detection includes detecting by analyzing a signal provided by the excitation beam when there is relative movement between the excitation beam and the probe molecules, wherein said relative movement results in the probe molecules being positioned in and out of the excitation beam.

US Pat. No. 10,084,631

TECHNIQUE FOR PAPR REDUCTION IN COMMUNICATION CHANNEL

RAMOT AT TEL-AVIV UNIVERS...

1. A method of mapping suitable for Peak to Average Power Ratio (PAPR) reduction while transmitting data portions via a communication channel limited by a peak power ppeak constraint,the mapping being performed by using a pulse shape filter with duration spanning over Ks symbols, and
a mapper configured to utilize a Markovian symbol transition probability distribution with quantized probabilities and to select, for a specific data portion at a current channel state, such a binary symbol, called thinned label,
wherein:
said Markovian distribution is based on a System model according to which the current channel state at time k, denoted sk, comprises a Ks?1 symbols sequence (ck?Ks+1, . . . , ck?1), a combination of the channel state sk and a symbol ck determines the next channel state sk+1;
the mapping utilizing said Markovian distribution comprises successively mapping the data portions into binary symbols in a manner that
a current binary symbol depends on said current channel state,
use of binary symbols, supposed to produce peak values exceeding the ppeak constraint, is avoided,
each binary symbol is expected to be used with its specific transition probability at the current channel state,
the Markovian distribution is quantized by forming at least one group of close transition probabilities and assigning to said group a common binary symbol and a rounded group probability, thus obtaining a non-uniform symbol distribution where the binary symbols, including said common binary symbol, are expected to be used with different transition probabilities;
said common binary symbol is replaced with said selected thinned label being a binary symbol comprising non-transmittable bits;
said thinned label thereby enables reduction of peak power produced by said label if transmitted, by allowing to puncture one or more bits in the thinned label's bit sequence before transmission,
the mapping thereby ensures reduction of peak values produced by said binary symbols, including said thinned label whenever selected for transmission, thus contributing to PAPR reduction.

US Pat. No. 10,016,154

PLACEABLE SENSOR AND METHOD OF USING SAME

Ramot at Tel-Aviv Univers...

1. A sensor system, comprising:a flexible substrate, having a front side and a back side;
a sensing assembly having a plurality of electrodes formed on said front side and being configured to provide electrochemical sensing;
a plurality of electrical contacts, formed on said back side and being in electrical communication with said sensing assembly via a plurality of interconnects passing through said substrate and extending at least from said front side to said back side; and
a mounting member configured for mounting said back side onto a tip of a movable device;
wherein when said flexible substrate is contacted with a target substance, said flexible substrate containing said electrodes deform, causing said electrodes to conform with a shape of said target substance and to contact said target substance.

US Pat. No. 9,953,402

IMAGING SYSTEM AND METHOD FOR IMAGING OBJECTS WITH REDUCED IMAGE BLUR

RAMOT AT TEL-AVIV UNIVERS...

1. A method for use in image processing for reducing image blur, the method being carried out by a computer system having data input and output utilities, memory and at least one data processor, the method comprising:receiving image data by the data input utility and storing the image data in the memory, the image data comprising a first image data piece obtained from light collection by a first optical arrangement having first numerical aperture and a second image data piece obtained from light collection by a second optical arrangement having a second numerical aperture being lower than the first numerical aperture, the first and second image data pieces being collected with respect to a common field of view,
processing, by the processor, the first and second image data pieces to obtain a reconstructed image of the field of view, including:
processing the second image data piece and determining shifted image data including: (i) digital summation of a weighted combination of N shifted image duplications of the second image data piece shifted with respect to the first image data piece, and (ii) determining combined image data being a summation of the first image data piece and the shifted data, thereby obtaining reconstructed image data based on the combined image data; and
generating output data indicative of the reconstructed image data by the output utility.
US Pat. No. 9,901,619

COMPOSITIONS COMPRISING PEDF AND USES OF SAME IN THE TREATMENT AND PREVENTION OF OVARY-RELATED SYNDROMES

Ramot at Tel-Aviv Univers...

1. A method of treating infertility associated with endometriosis in a subject in need thereof, the method consisting of administering
to the subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF) and an ovarian stimulating medication,
wherein said PEDF is administered subcutaneously, intramuscularly or orally, thereby treating infertility associated with
endometriosis in the subject.
US Pat. No. 9,879,225

ISOLATED CELLS AND POPULATIONS COMPRISING SAME FOR THE TREATMENT OF CNS DISEASES

Ramot at Tel-Aviv Univers...

1. A method of treating amyotrophic lateral sclerosis (ALS) or Parkinson's disease comprising administering to an individual
in need thereof a therapeutically effective amount of non-genetically modified GDNF-secreting cells which are ex vivo differentiated
from human mesenchymal stem cells, wherein said GDNF-secreting cells express glutamate transporter 1 (GLT1), wherein said
GDNF-secreting cells express CD90 and wherein a secretion of said GDNF is at least 5 times greater than a basal secretion
of said GDNF in a non-differentiated, non-genetically modified human mesenchymal stem cell, thereby treating ALS or Parkinson's.

US Pat. No. 9,629,824

INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION

Ramot at Tel-Aviv Univers...

1. A method for treating glaucoma comprising the step of administering to a patient in need thereof a therapeutically effective
amount of a compound of formula (I)
wherein:
R1 is hydrogen, —C1-6-alkyl, cycloC3-12-alkyl, —C(O)—R or —C(O)OR;

R2 is hydrogen, —C1-6-alkyl or cycloC3-12-alkyl;

R3 is —OR, —NHR or —NR2;

R4 is hydrogen, halogen, cyano, trifluoromethyl, —C1-6-alkyl, —C6-10-aryl, heteroaryl, —OR, —NHR, —NRR, —C(O)—R or —C(O)—NHR;

R5 is hydrogen, —C1-6-alkyl or C2-6-alkenyl;

R6 is hydrogen, —C1-6-alkyl or C2-6-alkenyl; or

R5 and R6 together with the carbon atoms carrying them form a cyclic system with 3 to 6 carbon atoms;

R is hydrogen, —C1-6-alkyl, or —C6-10-aryl;

X is —C(O)CH2—, —CH(OH)CH2—, —CH?CH— or —CH2—NH—C(O)—; and

R7 is hydrogen, methyl, ethyl, propyl or cyclopropyl;

or an optical isomer or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,591,853

JELLYFISH-DERIVED POLYMER

RAMOT AT TEL-AVIV UNIVERS...

1. A jellyfish polymer comprising jellyfish protein and at least one additive, wherein the additive is selected from the group
consisting of: a metal particle, an antibiotic agent, a coloring, guar, agar, alginic acid or a salt thereof, agarose, cellulose,
gelatin, glycerol, PVA (polyvinyl alcohol), PANPS (poly(2-acrylamido-2-methylpropanesulfonic acid)), hyaluronic acid; a nanoparticle,
a carbon nanotube, a multiwalled nanotube, fullerene, a nanodot, a dye, a nanorod, a cluster compound, graphene, a metal cluster
and a polyoxometalate cluster;
wherein the jellyfish protein comprises mucin and collagen.

US Pat. No. 10,565,716

METHOD AND SYSTEM FOR PROCESSING AN IMAGE

Ramot at Tel-Aviv Univers...

1. A method of processing an image, comprising:decomposing the image into a plurality of channels, each being characterized by a different depth-of-field;
accessing a computer readable medium storing an in-focus dictionary defined over a plurality of dictionary atoms, and an out-of-focus dictionary defined over a plurality of sets of dictionary atoms, each set corresponding to a different out-of-focus condition, said out-of-focus dictionary comprising a plurality of sub-dictionaries, each being characterized by a defocus parameter, wherein different sub-dictionaries correspond to different values of said defocus parameter; and
expressing the image as a combination of atoms of said dictionaries.
US Pat. No. 10,420,845

TAGGABLE HETEROAROMATIC DRUGS AND CONJUGATES THEREOF

Ramot at Tel-Aviv Univers...

1. A compound of the formula I:Y—CF2—(CR1R2)n—X—(CR1R2)m—R1  I
wherein
Y is a drug or a bioactive reagent, comprising a heteroaromatic ring and linked via a carbon atom of said heteroaromatic ring;
X is carbonyl, or cyclic ketal substituted with 1 to 4 groups each independently is phenyl or naphtyl substituted ortho to the carbon of attachment with —NO2, and optionally further substituted at any position other than ortho to the carbon of attachment with one or more groups each independently selected from the group consisting of —O—(C1-C8), —(C1-C8)alkyl, —N(R?)2, and halogen, wherein R? each independently is —(C1-C8)alkyl or H;
R1 and R2 each independently is H, halogen, —OR3, —CO—R3, —CO—OR3, —OCO—OR3, —OCO—N(R3)2, —CN, —NO2, —SR3, —N(R3)2, —CO—N(R3)2, —(C1-C8)alkyl, —(C2-C8)alkenyl, —(C2-C8)alkynyl, (C3-C10)cycloalkyl, (C6-C14)aryl, or 4-12-membered heterocyclyl;
R3 is H, —(C1-C18)alkyl, —(C2-C18)alkenyl, or —(C2-C18)alkynyl; and
n and m each independently is an integer of 1-8,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,253,251

NANOMATRIX SEPARATION OF CHROMOPHORES AND USES THEREOF IN LUMINESCENT DEVICES

RAMOT AT TEL-AVIV UNIVERS...

1. A multicolored organic light emitting diode (OLED) device comprising a film and optionally further an electrode assembly; said device having a monolayered or multilayered structure; wherein said film being a blend combination of a first association product of a first interactable material with a first glycoprotein shielding agent, said first association product having a first optical profile; a second association product of a second interactable material with a second glycoprotein shielding agent, said second association product having a second optical profile; and optionally a further interactable material, said further interactable material being optionally associated with a further glycoprotein shielding agent to form a further association product having an optical profile being different from the first and second optical profiles; wherein the blend combination has an optical profile being substantially an accumulation of the optical profiles of each of said association products present in the combination, wherein at least one of said first, second, and further interactable materials is a nanostructure.

US Pat. No. 9,925,275

AMPHOTERICIN B DERIVATIVES

RAMOT AT TEL-AVIV UNIVERS...

1. A pharmaceutical composition comprising:at least one compound according to Formula [I]

wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble PEG polymer having p PEG monomers, wherein p is from 6 to 40, or pharmaceutically acceptable salts, solvates, hydrates, and diastereomers thereof, including mixtures thereof in all ratios, and
a pharmaceutically acceptable carrier or diluent.

US Pat. No. 9,910,256

PORTABLE INTERFEROMETRIC DEVICE

RAMOT AT TEL-AVIV UNIVERS...

1. An optical system comprising:
a beam splitter/combiner unit for receiving an input beam of certain amplitude and phase modulation and splitting said input
beam into first and second light beams of the same amplitude and phase modulation and combining reflections of the first and
second light beams to produce an output combined beam;

a first and second reflective surfaces accommodated in the first and second optical paths of the first and second light beams
to thereby direct the first and second light beams back to the beam splitter/combiner;

a spatial filter comprising a pinhole accommodated in front of one of the first and second reflective surfaces in the optical
path of the first split light beam to apply amplitude and phase demodulation thereto and thereby form a demodulated reference
beam with respect to the second modulated beam and a Fourier optics assembly comprising two lenses;

thereby producing an interferogram comprising an interference pattern resulting from interaction of the reference and modulated
beams to be indicative of said amplitude and phase modulation,

wherein said interferometric system comprises an optical detector configured to receive said output combined beam and being
shifted to an edge of the interference pattern so that the interferogram appears on an area where the fringes are parallel
straight lines such that said interferometric system is configured and operable to reconstruct the sample phase profile using
a single interferogram exposure.

US Pat. No. 10,080,838

CATHETER CANNULA WITH ANCHORING ELEMENTS, CATHETER INCLUDING THEREOF, AND/OR CATHETERIZATION METHOD USING THEREOF

Ramot at Tel-Aviv Univers...

1. A cannula for fluid exchange with a body lumen, the cannula comprising:an elongated flexible tube having a single distal aperture, said elongate flexible tube coupleable to a needle such that said elongated flexible tube concentrically surrounds the needle, and having an invasive section and a non-invasive section and defining a lumen for fluid transfer; and
at least one anchoring element integral with said tube invasive section and permanently radially extending away from said tube, said tube having said at least one radially extending anchoring element extending away from an outermost surface of said tube invasive section adapted to be inserted into the body lumen when said at least one radially extending anchoring element extends away from said tube and said at least one anchoring element adapted to contact an inner wall of the body lumen, each of said at least one anchoring element configured for contacting the inner wall of the body lumen without damaging the inner wall of the body lumen, wherein said invasive section and said at least one anchoring element are formed from a single piece;
wherein a wall of said elongate flexible tube has a first thickness at a portion of said wall without one of said at least one anchoring elements and has a second thickness at a portion of said wall from which one of said at least one anchoring elements protrudes, said second thickness being greater than said first thickness; and
wherein each of said at least one anchoring element includes a leading edge and a trailing edge sloping away in a proximal direction from said leading edge.

US Pat. No. 9,627,693

ENERGY STORAGE AND GENERATION SYSTEMS

RAMOT AT TEL-AVIV UNIVERS...

1. An energy storage and generation system comprising:
at least one vessel suitable for holding an electrolyte;
at least one vessel suitable for holding a gas;
one or more stacks of regenerative fuel cells, said regenerative fuel cells comprising a housing; a proton conducting membrane
having a first surface and a second surface, disposed in said housing to partition it into an anode side and a cathode side;
an anode disposed on said first surface so as to connect said first surface to the anode side; a cathode disposed on said
second surface so as to connect said second surface to the cathode side; said anode comprising a support and a catalyst dispersed
thereon; said cathode comprising a carbon powder or a support and a catalyst dispersed thereon; wherein the catalyst dispersed
on said anode support and the catalyst dispersed on said cathode support are the same or different and are capable of catalyzing,
in the presence of an electrolyte or mixture of electrolytes, a charging reaction and a discharging reaction in said regenerative
fuel cells;

wherein said at least one vessel suitable for holding an electrolyte is in fluid communication with said one or more stacks
of regenerative fuel cells, and said one or more stacks of regenerative fuel cells are in fluid communication with said at
least one vessel suitable for holding an electrolyte, to form at least an electrolyte circulation loop;

wherein said at least one vessel suitable for holding a gas is in fluid communication with said one or more stacks of regenerative
fuel cells, and said one or more stacks of regenerative fuel cells are in fluid communication with said at least one vessel
suitable for holding a gas, to form at least a gas circulation loop; and

wherein said proton conducting membrane has pores with a diameter size which are smaller than 30 nm and comprises: (i) 5%
to 60% by volume of an electrically nonconductive inorganic powder having acid absorption capacity, wherein the powder comprising
essentially sub-micron particles; (ii) 5% to 50% by volume of a polymeric binder that is chemically compatible with acid,
oxygen and fuel; and (iii) 10 to 90% by volume of an acid or aqueous acid solution;

wherein the one or more stacks of regenerative fuel cells further comprise (i) an electrolyte feed inlet opening and an electrolyte
feed line extending from the electrolyte feed inlet opening exteriorly from the one or more stacks of regenerative fuel cells,
said electrolyte feed line in fluid communication with said at least one vessel suitable for holding an electrolyte, for delivery
of electrolyte into the one or more stacks of regenerative fuel cells; and (ii) an electrolyte discharge outlet opening and
an electrolyte discharge line extending from the electrolyte discharge outlet opening exteriorly from the one or more stacks
of regenerative fuel cells, said electrolyte discharge line in fluid communication with said at least one vessel suitable
for holding an electrolyte, for removal of electrolyte from the one or more stacks of regenerative fuel cells;

wherein at least a portion of the electrolyte feed line adjacent to the electrolyte feed inlet opening has a coiled configuration,
and at least a portion of the electrolyte discharge line adjacent to the electrolyte discharge outlet opening has a coiled
configuration; and

wherein the diameter and length of at least a portion of the electrolyte feed line adjacent to the electrolyte feed inlet
opening having a coiled configuration, and the diameter and length of at least a portion of the electrolyte discharge line
adjacent to the electrolyte discharge outlet opening having a coiled configuration, are determined by the equation

R=3.14*(D/2)2*X*S
(Volts)—the total voltage in the array of stacks connected in series,
I (Amp)—the operating current of each stack,
L (%)—approved percentage of shunt current losses in the system,
IL (Amp)—current losses by shunt=I*L,
R (Ohm)—tubing ionic resistance=V/IL,
S (Ohm/cm3)—solution resistance,

D (cm)—tubing diameter, and
X (cm)—tubing length.
US Pat. No. 10,633,706

ANALYSIS OF METHYLATION STATUS AND COPY NUMBER

Ramot at Tel-Aviv Univers...

1. A method of diagnosing a disease associated with a DNA repeat sequence comprising:(a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject by covalently attaching to the DNA molecules a detectable moiety which labels said repeats of said DNA sequence using i) a sequence-specific CpG-methylation-insensitive DNA methyltransferase (DNA MTase) or ii) a sequence specific nicking enzyme in a nick-labeling-repair (NLR) reaction or both i) and ii); and
(b) determining the CpG methylation status of said DNA molecules, wherein the number of repeats of said DNA sequence and the CpG methylation status of said DNA molecules is indicative of the disease,
wherein the number of repeats and the CpG methylation status are determined for the same DNA molecules of said sample by dual labeling.

US Pat. No. 10,636,832

SYSTEM AND METHOD FOR SENSING LIGHT

Ramot at Tel-Aviv Univers...

1. A light sensor, comprising a nanostructure connectable to a source electrode and a drain electrode, and light sensitive moiety covalently attached to a surface of said nanostructure, said light sensitive moiety comprising a light sensitive molecule having an absorbance spectrum in a visible range, said light sensitive molecule being selected such that upon irradiation of the light sensor by light having a central wavelength within said absorbance spectrum, said sensitive molecule transfers or extracts an electron to or from said surface of said nanostructure.
US Pat. No. 10,537,631

TILAPIA LAKE VIRUS VACCINES

Ramot At Tel-Aviv Univers...

1. A vaccine composition comprising an attenuated strain of Tilapia Lake Virus (TiLV) obtained by selection of avirulent strain by serially passaging in vivo, for protecting tilapia fish against infection by virulent TiLV.

US Pat. No. 10,205,527

LINEARIZED OPTICAL DIGITAL-TO-ANALOG MODULATOR

Ramot at Tel-Aviv Univers...

1. A modulator system for converting input digital data word into analog modulation of an input optical signal, the modulator system comprising:an electronic input for receiving digital input data word comprising a plurality of bits;
a plurality of optical waveguide branches carrying at least an input optical signal passing therein, and a plurality of actuating electrodes disposed over the plurality of optical waveguide branches; and
wherein the modulator system is responsive to an input of said digital input data word to supply a binary actuation vector of binary electrode-actuation voltages to the plurality of actuating electrodes, wherein a number of said actuating electrodes is at least equal to a number of bits in the digital input data word; and
wherein the binary electrode-actuation voltages supplied to said actuating electrodes modulate the power and optical phase delay of at least the input optical signal to generate a modulated optical output signal.
US Pat. No. 10,040,836

PEPTIDES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Ramot at Tel-Aviv Univers...

1. A method of treating Alzheimer's disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence as set forth in SEQ ID NO: 2, wherein the peptide is capable of specifically inhibiting the activity of caspase 6, thereby treating the Alzheimer's disease.

US Pat. No. 10,709,867

GAZE-CONTINGENT MUSIC REWARD THERAPY

RAMOT AT TEL-AVIV UNIVERS...

1. A computerized method for treating a psychopathological condition, the method comprising using at least one hardware processor for:presenting, using an audio playback device, at least audio media to a patient;
receiving, from an eye tracker, a gaze direction of at least one eye of the patient;
computing a difference angle between a target direction and the gaze direction; and
pausing the audio media for a period of time, based, at least in part, on said computing,
wherein subsequent to the pausing, the audio media is at least in part rewound.

US Pat. No. 10,635,934

METHOD AND SYSTEM FOR IMAGE CONTENT RECOGNITION

Ramot at Tel-Aviv Univers...

1. A method of recognizing image content, comprising:applying a neural network to the image, said neural network comprising an input layer for receiving the image, a plurality of hidden layers for processing the image, and an output layer for generating output pertaining to an estimated image content based on outputs of said hidden layers;
applying a neural network branch to an output of at least one of said hidden layers, said neural network branch being independent of said neural network and having an output layer for generating output pertaining to an estimated error level of said estimate; and
generating a combined output indicative of the estimated image content and the estimated error level.

US Pat. No. 10,548,502

LOCALIZING ELECTRICAL ACTIVITY IN THE BRAIN USING VIBRATION OF THE CEREBRAL CORTEX

RAMOT AT TEL-AVIV UNIVERS...

1. A diagnostic method, comprising:applying a vibration at a selected frequency to a location within a brain of a living subject;
measuring electrical signals resulting from the vibration at multiple positions on a scalp of the subject;
processing the measured electrical signals in order to compute an electrical gain matrix between the location within the brain and the positions on the scalp;
measuring electroencephalogram (EEG) signals at the multiple positions on the scalp; and
filtering the EEG signals using the gain matrix in order to identify brain electrical activity originating from the location.

US Pat. No. 10,497,537

METHOD AND DEVICE FOR MANIPULATING PARTICLE BEAM

Ramot at Tel-Aviv Univers...

1. A method of manipulating a particle beam, comprising:transmitting the beam through a phase mask selected to spatially modulate a phase of a wavefront of the beam over a cross-section thereof, wherein said phase modulation is selected to at least partially compensate for aberration generated by a beam focusing system; and
applying a multipole electromagnetic field to the beam so as to also at least partially compensate for aberrations generated by said beam focusing system;
wherein said compensation by said multipole electromagnetic field is complementary to said compensation by said phase mask.

US Pat. No. 10,422,780

ELECTROCHEMICAL DETECTION OF PEROXIDE-CONTAINING COMPOUNDS

Ramot at Tel-Aviv Univers...

1. A sensing electrode comprising a carbon electrode and a functional moiety being in association with at least a portion of a surface of said electrode, said functional moiety comprising at least one metal species that promotes decomposition of hydrogen peroxide, wherein said functional moiety comprises an organic salt of said metal which comprises metal ions and organic anions and particles of said metal, wherein a mol ratio of said metal ions and said particles of said metal ranges from 70:30 to 30:70, and wherein said metal is silver.
US Pat. No. 10,251,943

PLIF MULTIMERIC PEPTIDES AND USES THEREOF

Ramot at Tel-Aviv Univers...

1. A method of treating breast cancer, the method comprising administering a therapeutically effective amount of a dimer to a subject in need thereof, said dimer comprising two peptide monomers covalently linked to one another, each of said two peptide monomers comprising the amino acid sequence as set forth in SEQ ID NO: 1, wherein said two peptide monomers are no longer than 30 amino acids, thereby treating the breast cancer.

US Pat. No. 10,403,414

CONDUCTIVE NANOWIRE FILMS

RAMOT AT TEL-AVIV UNIVERS...

1. A process for the preparation of a conductive film, said process comprising:(a) obtaining an aqueous precursor solution comprising at least one metal precursor, at least one surfactant and at least one metal reducing agent;
(b) forming a thin-film of the precursor solution on at least a portion of a surface of a substrate; and
(c) allowing formation of a first layer of metal nanowires;
wherein one or both of the steps (d) and (e) are carried out:
(d) forming a stacking of two or more metal nanowire layers by forming a further layer or layers on a surface of the first layer of metal nanowires, wherein the further layer or layers is formed in same manner as that of the formation of the first layer of metal nanowire; and
(e) treating the layer of metal nanowires or the stacking of metal nanowire layers with a solution comprising at least one surfactant, at least one metal precursor and at least one weak metal reducing agent;
to thereby obtain the conductive film of nanowires on at least a portion of said surface of the substrate,
the conductive film comprising
at least one conductive layer, comprising
an arrangement of electrically conductive metal nanowires, the nanowires having on average an aspect-ratio of at least 100,000, at least 70% of said nanowires being arranged in one or more clusters, wherein each cluster comprising two or more nanowires oriented parallel to each other along the same axis, wherein the inter-wire spacing within the cluster is below 20 nm.
US Pat. No. 10,238,722

PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT OF UTERINE FIBROIDS

Ramot at Tel-Aviv Univers...

1. A method of treating uterine fibroid in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating the uterine fibroid in the subject.
US Pat. No. 10,179,113

CELL-TARGETING NANOPARTICLES COMPRISING POLYNUCLEOTIDE AGENTS AND USES THEREOF

RAMOT AT TEL-AVIV UNIVERS...

1. A particle comprising a core and a shell, wherein the core comprises 1,2-Dilauroyl-sn-Glicero-3-Phosphorylglycerol (DLPG), a lipid having an amino group which is 1,2-Dilauroyl-sn-Glicero-3-Phosphoethanolamine (DLPE), a polynucleotide, and optionally a cationic lipid and/or cholesterol; wherein the shell comprises a glycosaminoglycan targeting moiety; and wherein the particle is not a liposome.
US Pat. No. 10,570,369

PLURIPOTENT AUTOLOGOUS STEM CELLS FROM ORAL MUCOSA AND METHODS OF USE

RAMOT AT TEL-AVIV UNIVERS...

1. In a method of treating a tissue disorder or disease, comprising administering to a patient in need thereof multipotent or pluripotent stem cells and providing conditions for differentiation of said cells into cells characterizing said tissue, thereby treating the individual suffering from the tissue disorder or disease, the improvement wherein said pluripotent or multipotent stem cells are pluripotent or multipotent stem cells derived from the lamina propria of the mucosa of the gastrointestinal tract, wherein said stem cells express at least one stem cell marker selected from the group consisting of Oct-4, Tra-1-61, Tra1-81, Tra-2-49, Tra-2-54, SSEA1-4, Rex1, Nanog, Sox2 ABCG2, hTert, Bmi1, CD29, CD44, CD 73, CD90, CD105, CD106, CD117 CD146, CD166 and Strol+.

US Pat. No. 10,488,175

MULTI WAVELENGTH MULTIPLEXING FOR QUANTITATIVE INTERFEROMETRY

RAMOT AT TEL-AVIV UNIVERS...

1. An off-axis interferometric module comprising a light directing optical arrangement for directing light to an optical detector, wherein the light directing optical arrangement is configured for defining at least two substantially overlapping optical paths towards the optical detector, the light directing optical arrangement comprising:at least one wavelength selective filter, configured for receiving a multiple-wavelength light beam having a modulated complex wave front and having at least two spectral bandwidths and separating the multiple-wavelength modulated beam into at least two wavelength-separated beams, each defining N different wavelength channels;
at least two reflecting surfaces defining a certain angle with respect to each other and positioned at the output of said wavelength selective filter; each reflecting surface being configured for receiving and rotating each wavelength-separated beam of each wavelength channel at a certain angle and back reflecting each wavelength-separated beam towards the detector through a beam combiner being configured for receiving and combining reflections of each wavelength-separated beam with a reference beam to produce at least two output combined beams propagating along said at least two substantially overlapping optical paths; said at least two output combined beams being thereby at least two off-axis overlapping interferograms to be optically multiplexed into a single off-axis interferogram, containing interference fringe orientation in different directions.

US Pat. No. 10,461,866

LINEARIZED OPTICAL DIGITAL-TO-ANALOG MODULATOR

Ramot at Tel-Aviv Univers...

1. A modulation system for modulating and transmitting an optical signal over at least one optical fiber in response to an input digital data word of N bits, the modulation system comprising:an input enabled for receiving the digital data word into the modulation system;
an electrically controllable modulator having one or more waveguide branches, where each branch receives an input of an unmodulated optical signal;
a digital to digital converter enabled for converting the N bits of the input digital data word to a digital drive vector corresponding to M drive voltage values, where M>N and N>1;
the electrically controllable modulator further enabled for coupling the drive voltage values corresponding to the digital drive vector to the unmodulated optical signal(s), said coupling enabling pulse modulation of the unmodulated optical signal(s), thereby generating pulse modulated optical signal(s), and outputting said pulse modulated optical signal(s) to one or more outputs;
the one or more outputs enabled for transmitting the pulse modulated optical signal(s) over at least one optical fiber.

US Pat. No. 10,311,555

IMAGING SYSTEM AND METHOD FOR IMAGING OBJECTS WITH REDUCED IMAGE BLUR

RAMOT AT TEL-AVIV UNIVERS...

1. A system comprising, an imaging system and a processor utility, the imaging system comprising:first and second lens systems having corresponding first and second numerical apertures and both directed for imaging of a common object plane, the second numerical aperture is smaller than the first numerical aperture;
an image detection unit for detecting light collected by the first and second lens systems and generating corresponding first and second image data pieces indicative of the object plane from a common direction; and
the processor utility is configured to:
receive the first image data piece and the second image data piece that are collected with respect to the common object plane, and
process the first and second image data pieces to provide a reconstructed image of the field of view.

US Pat. No. 10,337,851

FAST PHASE PROCESSING OF OFF-AXIS INTERFEROGRAMS

RAMOT AT TEL-AVIV UNIVERS...

23. A system for rapidly processing off-axis interferogram images, said system comprising at least one processing unit and one or more computer-readable media storing computer executable modules executed by said at least one processing unit, said computer executable modules comprising:an input module configured to receive at least two interferogram images generated using an optical setup configured to generate said at least two of the interferogram images with association with a sample;
an image generation module configured to generate a combined interferogram image for exploiting empty spatial-frequency domain areas, and ensure separation between auto-correlation and cross-correlation spatial-frequency domain terms, of the generated combined interferogram image, by combining said at least two interferogram images by at least one of multiplexing and complex summation, said multiplexing comprising image rotation and superimposition and in said complex summation at least one of said at least two interferogram images is used in a real part of said complex summation and at least another one of said at least two interferogram images is used in an imaginary part of said complex summation;
a transformation module configured to decompose said combined interferogram image within a single spectral decomposition operation of said combined interferogram image and generate spectra data of said at least two interferogram images;
a cropper module configured to crop respective at least two portions of said spectra data, each of said at least two portions having a substantially reduced size with respect to the respective interferogram image;
an inverse transformation module configured to generate from the at least two cropped spectra data portions having the substantially reduced size respective at least two complex images having the substantially reduced size and being indicative of phase data of said at least two interferogram images; and
a phase unwrap module configured to rapidly unwrap phase image of said respective at least two complex images having the substantially reduced size and generate respective phase images therefrom.

US Pat. No. 10,532,113

POLYMERIC SYSTEMS AND USES THEREOF IN THERANOSTIC APPLICATIONS

Ramot at Tel-Aviv Univers...

1. A polymeric conjugate comprising a polymeric backbone composed of a plurality of backbone units and having attached to at least a portion of said backbone units a fluorogenic moiety, said fluorogenic moiety being attached to said portion of backbone units via a cleavable linking moiety such that upon cleavage of said linking moiety, a fluorescent moiety is generated, wherein said fluorescent moiety is a cyanine dye, and wherein the polymeric conjugate further comprises a quenching agent, the polymeric conjugate having a molecular weight in a range of from 10 kDa to 60 kDa, and is being such that said plurality of backbone units comprises two or more different portions of backbone units that differ from one another by the presence and/or nature of the moiety attached thereto, wherein one portion of the backbone units have said fluorogenic moiety attached thereto via said cleavable linking moiety and one another portion of the backbone units do not have a moiety attached thereto or have said quenching agent attached thereto, and wherein said different backbone units are randomly dispersed within said polymeric backbone,the polymeric conjugate being represented by Formula IA:

wherein:
A1, A2 and A4 are said backbone units;
F is said fluorogenic moiety;
Q is said quenching agent;
L2 is said cleavable linking moiety, linking said fluorogenic moiety to each of backbone units A2;
S2 is a first spacer, linking said fluorogenic moiety to L2, or is absent;
L4 is a cleavable or non-cleavable linking moiety linking said quenching agent to backbone units A4, or is absent;
S4 is a spacer linking said quenching agent to L4, or is absent;
w is an integer having a value such that w/(x+s+w) multiplied by 100 is in the range of from 70 to 99.9;
x is an integer having a value such that x/(x+s+w) multiplied by 100 is in the range of from 0.1 to 20; and
s is a positive integer having a ratio to said x in a range of from 20:1 to 1:20,
such that:
each [A2-L2-S2-F] independently represents a backbone unit having attached thereto said fluorogenic moiety; and
each [A4-L4-S4-Q] independently represents a backbone unit having attached thereto said quenching agent,
wherein said [A1], [A2-L2-S2-F] and [A4-L4-S4-Q] backbone units are arranged in any order.

US Pat. No. 10,363,169

SYSTEM AND METHOD FOR TREATING AN EYE

TEL HASHOMER MEDICAL RESE...

1. A method, comprising:providing a system that comprises a laser source and a hardware-implemented beam-shaping device comprising one or more optical elements;
generating electromagnetic radiation by the laser source; and
irradiating one or more regions of a trabecular meshwork of an eye with the electromagnetic radiation generated by the laser source, by directing the electromagnetic radiation using the beam-shaping device through an entire thickness of a scleral limbus of the eye without any contact with the eye.

US Pat. No. 10,270,535

LINEARIZED OPTICAL DIGITAL-TO-ANALOG MODULATOR

Ramot at Tel-Aviv Univers...

2. A method of modulating and transmitting an optical signal over an optical fiber in response to N bits of digital data in parallel, the method comprising:inputting the N bits of digital data into an optical modulator having a plurality of waveguide branches, where each branch has an input of an unmodulated optical signal;
converting the N bits of digital data to M drive voltage values, where M>N and N>1; coupling the M drive voltage values to the unmodulated optical signal, said coupling enabling modulation of the unmodulated optical signal by QAM, thereby generating a QAM modulated optical signal; and
transmitting the QAM modulated optical signal over an optical fiber.
US Pat. No. 10,543,278

IMMUNOPARTICLES AND METHODS OF GENERATING AND USING SAME

Ramot at Tel-Aviv Univers...

1. An immunoparticle comprising a humanized secondary antibody coupled on an outer surface of a particle, wherein said secondary antibody is bound specifically to an Fc region of an isolated humanized or human primary antibody.

US Pat. No. 10,310,287

SYSTEM AND METHOD FOR CONTROLLING LIGHT BY AN ARRAY OF OPTICAL RESONATORS

Ramot at Tel-Aviv Univers...

1. An optical system, comprising a refractive optical element, and an array of optical resonators, said refractive optical element and said array being positioned on the same optical axis,wherein said array of optical resonators comprises at least a first type of optical resonators each having a resonant response to an optical field at a first wavelength, and a second type of optical resonators each having a resonant response to an optical field at a second wavelength, being different from said first wavelength, said resonant responses being selected to reduce chromatic aberrations associated with said refractive optical element;
wherein different types of optical resonators engage different surfaces.