US Pat. No. 9,161,247

METHOD AND APPARATUS FOR USING CHANNEL OUTPUT FEEDBACK IN MULTI USER WIRELESS SYSTEMS AND HYBRID-ARQ

Samsung Electronics Co., ...

1. A terminal for transmitting a signal using a channel output feedback, the terminal comprising:
a transmitter configured to transmit, to a base station, a first packet being applied a precoder received from the base station;
a receiver configured to receive, from the base station, a Channel Output Feedback (COF) of the transmitted first packet and
information for transmitting a second packet, wherein the information for transmitting the second packet is information on
a channel state between the terminal and the base station determined based on a channel output of the transmitted first packet;
and

a controller configured to prepare a variant of the second packet using the COF and the received information for transmitting
the second packet, and to control to transmit the prepared variant to the base station,

wherein the COF of the transmitted first packet is a received signal of first packet received by the base station.

US Pat. No. 9,130,742

KEY AGREEMENT IN WIRELESS NETWORKS WITH ACTIVE ADVERSARIES

CALIFORNIA INSTITUTE OF T...

1. A network of computers with error correction code configured to transmit keys secretly and securely by:
encoding a key on a first single computer-based workstation,
forwarding a plurality of encoded files via a plurality of computer-based workstations, and
decoding the plurality of encoded files on a second single computer-based workstation using a decoding algorithm to retrieve
the key; and the network comprising:

the first single computer-based workstation operating as a source node and configured to encode the key and forward, via a
first plurality of intermediate transmission links, a distinct encoded file to each intermediate node within a plurality of
intermediate nodes of the network,

the plurality of computer-based workstations operating as intermediate nodes and configured to receive via the first plurality
of intermediate transmission links the encoded source files from the source node and forward via a second plurality of intermediate
transmission links the encoded files to a receiver node when requested, and

the second single computer-based workstation operating as a receiver node and configured to receive, via the second plurality
of intermediate transmission links, encoded files from the plurality of intermediate nodes and decode the encoded files to
retrieve the key,

wherein a particular intermediate node, with corresponding intermediate transmission links from the first and second plurality
of intermediate transmission links, forms a two-hop path between the source node and the receiver node, and

wherein one or more of the encoded files received by the receiver node may be erroneous due to an erroneous intermediate transmission
link and/or an erroneous intermediate node.

US Pat. No. 9,203,030

RECYCLABLE ORGANIC SOLAR CELLS ON SUBSTRATES COMPRISING CELLULOSE NANOCRYSTALS (CNC)

Georgia Tech Research Cor...

1. A recyclable organic solar cell comprising:
a first electrode;
a second electrode;
a photoactive layer disposed between the first electrode and the second electrode;
an interlayer comprising a Lewis basic oligomer or polymer disposed between the photoactive layer and at least a portion of
the first electrode or the second electrode; and

a substrate comprising cellulose nanocrystals disposed adjacent to the first electrode or the second electrode;
wherein one or more of the first electrode, the second electrode, the photoactive layer, the interlayer, and the substrate
of the organic solar cell comprise recyclable material.

US Pat. No. 9,217,010

N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF

PURDUE RESEARCH FOUNDATIO...

1. A process for preparing a compound of the formula

without isolating an intermediate product, the process comprising: reacting a compound of the formula

with a compound of the formula

 and
cyclizing the intermediate product
wherein
Ra represents 1-4 substituents each of which is independently selected from the group consisting of hydrogen, halo, hydroxy,
optionally substituted alkyl, optionally substituted alkoxy, cyano, nitro, optionally substituted alkylthio, optionally substituted
alkylsulfonyl, carboxylic acid and derivatives thereof, and sulfonic acid and derivatives thereof; or Ra represents 2-4 substituents where 2 of said substituents are adjacent substituents and are taken together with the attached
carbons to form an optionally substituted heterocycle, and where any remaining substituents are each independently selected
from the group consisting of hydrogen, halo, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, cyano,
nitro, optionally substituted alkylthio, optionally substituted alkylsulfonyl, carboxylic acid and derivatives thereof, and
sulfonic acid and derivatives thereof;

Rd represents 1-4 substituents each of which is independently selected from the group consisting of hydrogen, halo, hydroxy,
optionally substituted alkyl, optionally substituted alkoxy, cyano, nitro, optionally substituted alkylthio, optionally substituted
alkylsulfonyl, carboxylic acid and derivatives thereof, and sulfonic acid and derivatives thereof; or Rd represents 2-4 substituents where 2 of said substituents are adjacent substituents and are taken together with the attached
carbons to form an optionally substituted heterocycle, and where any remaining substituents are each independently selected
from the group consisting of hydrogen, halo, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, cyano,
nitro, optionally substituted alkylthio, optionally substituted alkylsulfonyl, carboxylic acid and derivatives thereof, and
sulfonic acid and derivatives thereof.

US Pat. No. 9,460,485

SYSTEMS AND METHODS FOR GUIDED DE-NOISING FOR COMPUTED TOMOGRAPHY

GENERAL ELECTRIC COMPANY,...

1. A method comprising:
obtaining spectral computed tomography (CT) information via an acquisition unit comprising an X-ray source and a CT detector;
generating, with one or more processing units, using at least one image transform, a first basis image and a second basis
image using the spectral CT information;

performing, with the one or more processing units, guided processing on the second basis image using the first basis image
as a guide to provide a modified second basis image;

performing a first inverse image transform using the first basis image and the modified second basis image to provide a first
modified image; and

performing a second inverse image transform using the first basis image and the modified second basis image to provide a second
modified image.

US Pat. No. 9,595,430

LASER DESORPTION IONIZATION MASS SPECTROMETRY USING A PARTICULATE SEPARATION BED

LI-COR, INC., Lincoln, N...

1. A mass spectrometry method, said method comprising:
introducing a sample into interstitial spaces between a plurality of silica particles arranged in a regular, body centered
cubic crystalline structure, said plurality of silica particles extending in a longitudinal direction;

applying a voltage along said longitudinal direction to resolve one or more analytes from said sample;
irradiating a first analyte from said resolved one or more analytes in said interstitial spaces between said silica particles
under conditions sufficient to produce analyte ions;

separating a first analyte ion from said analyte ions using a mass analyzer; and
detecting said first analyte ion using a detector.

US Pat. No. 9,332,156

GLARE AND SHADOW MITIGATION BY FUSING MULTIPLE FRAMES

Hewlett-Packard Developme...

1. A method for glare nd shadow mitigation by fusing multiple frames comprising:
illuminating a target with light from a first illumination direction;
capturing a first frame of the target with a camera while the target is illuminated in the first illumination direction;
illuminating the target with light from a second illumination direction;
capturing a second frame of the target with the camera while the target is illuminated in the second illumination direction;
and

fusing, in a single operation, the first frame and the second frame such that glares and shadows are simultaneously mitigated
to form a composite image with mitigated glare and shadow areas.

US Pat. No. 9,163,398

SOUND BARRIER SYSTEMS

PURDUE RESEARCH FOUNDATIO...

1. A cellular material barrier system for reducing sound transmission comprising:
a planar cellular metamaterial arrangement, including at least one unit cell, the unit cell including
a sound normalizing arrangement; and
a planar metamaterial arrangement coupled to the sound normalizing arrangement on a first side, the planar metamaterial arrangement
including

a plate, and
a frame affixed to the plate,
the sound normalizing arrangement configured to normalize incident sound received at non-normal angles to thereby convey sound
at normal angles to the planar metamaterial arrangement.

US Pat. No. 9,170,912

SYSTEM AND METHODS FOR POWER AND ENERGY MODELING IN COMPUTING DEVICES USING SYSTEM CALL TRACING

Purdue Research Foundatio...

14. A computing device comprising:
a memory configured to store program data;
a processor operatively connected to the memory;
a component connected to the processor to enable the processor to communicate with the component; and
the processor being configured to:
receive data from an external power monitor corresponding to power consumption of the computing device in a first power state;
execute program instructions stored in the memory corresponding to a first system call, the processor operating a component
in response to execution of the first system call;

receive data from the external power monitor corresponding to power consumption of the computing device in a second power
state in response to execution of the first system call to identify a level of power consumption and a duration of the second
power state, the level of power consumption in the second power state being different than a level of power consumption in
the first power state;

receive data from the external power monitor corresponding to power consumption of the computing device in a third power state
after a transition from the second power state to identify a level of power consumption and a duration of the third power
state, the level of power consumption in the third power state being different than the level of power consumption in each
of the first power state and the second power state;

generate a finite state machine (FSM) model including the first power state, the second power state, and the third power state,
the FSM model including a transition from the first power state to the second power state being made with reference to the
execution of the first system call, a transition from the second power state to the third power state being made in response
to expiration of the duration of the second power state, and a transition from the third power state to the first power state
being made in response to expiration of the duration of the third power state; and

store the FSM model in the memory for estimation of energy usage of the computing device in response to execution of the first
system call by the processor in conjunction with the at least one other component.

US Pat. No. 9,062,057

CCR5 ANTAGONISTS FOR TREATING HIV

Purdue Research Foundatio...

1. A compound of the formula:

or a pharmaceutically acceptable salt thereof, wherein:
A is

R1 is hydrogen or optionally substituted alkyl;

R2 is alkylsulfonyl or arylsulfonyl, each of which is optionally substituted;

R3 is hydrogen or optionally substituted alkyl;

R4 is optionally substituted aryl; and

R5 is acyl, acylamino, sulfonyl, or sulfonylamino;

wherein acyl or acyl in acylamino is alkyloxycarbonyl, cycloalkyloxycarbonyl, heteroalkyloxycarbonyl, cycloheteroalkyloxycarbonyl,
alkylaminocarbonyl, cycloalkylaminocarbonyl, heteroalkylaminocarbonyl, cycloheteroalkylaminocarbonyl, aryloxycarbonyl, arylalkyloxycarbonyl,
arylaminocarbonyl or arylalkylaminocarbonyl, each of which is optionally substituted;

or A is:

R1 is hydrogen or optionally substituted alkyl;

R2 is alkylsulfonyl or arylsulfonyl, wherein the alkyl in alkyl sulfonyl is optionally substituted and the aryl in arylsulfonyl
is substituted;

R3 is hydrogen or optionally substituted alkyl;

R4 is optionally substituted aryl; and

R5 is acyl, acylamino, sulfonyl, or sulfonylamino;

wherein acyl or acyl in acylamino is alkyloxycarbonyl, cycloalkyloxycarbonyl, heteroalkyloxycarbonyl, cycloheteroalkyloxycarbonyl,
alkylaminocarbonyl, cycloalkylaminocarbonyl, heteroalkylaminocarbonyl, cycloheteroalkylaminocarbonyl, aryloxycarbonyl, arylalkyloxycarbonyl,
arylaminocarbonyl or arylalkylaminocarbonyl, each of which is optionally substituted.

US Pat. No. 9,295,064

METHODS, SYSTEMS AND APPARATUS TO FACILITATE RANKED NETWORK PRIORITY

Purdue Research Foundatio...

1. A method to allocate resources of a wireless network, comprising:
calculating a rank of a first wireless device relative to a plurality of wireless devices based on a first bid value associated
with the first wireless device;

allocating a first bit rate to the first wireless device based on the rank of the first wireless device at a first time; and
in response to detecting a change in availability of the first bit rate at a second time, applying a second bid value for
a second bit rate when the first wireless device is located in a first geographic area, and applying a third bid value for
the second bit rate when the first wireless device is located in a second geographic area different from the first geographic
area.

US Pat. No. 9,134,318

DETECTION OF OXIDIZED POLYPEPTIDES

Purdue Research Foundatio...

1. A method for determining whether a subject is afflicted with diabetes mellitus comprising:
obtaining a blood or plasma sample from said subject comprising at least one carbonylated protein selected from Table 15,
wherein the carbonylated protein comprises a plurality of carbonylated sites;

isolating the carbonylated protein from the other oxidized proteins in the sample via an affinity purification technique,
wherein the step of isolating comprises:

coupling a first member of a binding pair to the carbonylated protein;
contacting the sample to a chromatographic support matrix that comprises a second member of the binding pair such that the
carbonylated protein is retained in the support matrix via a binding between the first and second members of the binding pair
while the other oxidized proteins flow through the matrix;

digesting the isolated carbonylated protein into a plurality of different carbonylated peptides;
determining and quantitatively assessing by a liquid chromatography-mass spectrometry technique a degree of oxidation at each
of a plurality of carbonylated sites found in one or more of the carbonylated peptides obtained from the following carbonylated
proteins from as disclosed in Table 15: hemoglobin alpha 2 chain; major beta-hemoglobin; fibrinogen alpha chain; fatty acid
binding protein, immunoglobulin heavy chain, and complement component 3;

comparing the degree of oxidation at each of the plurality of carbonylated sites to a degree of oxidation at each of the same
sites found in one or more reference peptides; and

detecting a difference in the degree of oxidation at the plurality of the carbonylated sites between the one or more carbonylated
peptides and the reference peptides, wherein a greater than 1.5 fold increase in the degree of oxidation at the plurality
of the carbonylated sites is indicative of the subject being afflicted with diabetes mellitus.

US Pat. No. 9,335,420

DETECTION OF NEUTRINOS

Purdue Research Foundatio...

1. A flux detection apparatus comprising:
a radioactive sample having an atomic mass of at least about 19 and a decay rate capable of changing in response to neutrinos;
a detector associated with the radioactive sample, the detector responsive to at least one of a particle or radiation formed
by decay of the radioactive sample; and

a processor associated with the detector, the processor (i) correlating rate of decay of the radioactive sample to a flux
of the neutrinos and (ii) identifying a specific change in the flux of neutrinos.

US Pat. No. 9,073,832

CLASS II HMG-COA REDUCTASE INHIBITORS AND METHODS OF USE

Purdue Research Foundatio...

1. An inhibitor of Class II 3-hydroxy-3-methylglutaryl-coenzyme A reductase having one of the following structures:

wherein:
R1=is a hydroxyl;

R2=is H;

D is CR4, wherein R4 is (CH2)4CH(CH3)2, (CH2)3CH(CH3)2, (CH2)2C(CH3)3 cyclohexylethyl, or (CH2)mRc, wherein m=6-14 and RC=H;

R5=H;

A, B, E, X, Y, and Z are each CH;
or a pharmaceutically acceptable salts thereof.

US Pat. No. 9,058,967

DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE

Purdue Research Foundatio...

1. A method for analyzing a sample, the method comprising:
discontinuously receiving sample ions to a mass analyzer of a mass spectrometer in a manner in which the mass analyzer is
periodically open for a period of time that causes the pressure in the mass analyzer to increase above a pressure at which
mass analysis or ion manipulation can be conducted and is periodically closed while the mass analyzer is evacuated to a pressure
at which mass analysis or ion manipulation can be conducted; and

performing mass analysis on the sample ions while the mass analyzer is at a pressure at which mass analysis or ion manipulation
can be conducted.

US Pat. No. 9,211,611

LASER CRYSTALLIZATION OF THIN FILMS ON VARIOUS SUBSTRATES AT LOW TEMPERATURES

Purdue Research Foundatio...

1. A method of inducing crystallization in thin films with a laser system, the method comprising:
obtaining a thin film comprising a substrate and a target layer deposited on the substrate, wherein the target layer comprises
nano-scale particles;

determining the heat conduction between the target layer and the substrate of the thin film based on thermal input from the
laser system to identify operating parameters for the laser system that cause crystallization and crystal growth of the nano-scale
particles of the target layer in an environment at near room temperature with the substrate remaining at a temperature below
the temperature of the target layer;

transmitting a laser beam of the laser system along an optical path to impinge the target layer of the thin film; and then
pulsing the laser beam to create a localized rapid heating and cooling of the target layer, wherein the laser system is operated
at the operating parameters identified in the determining step to crystallize and induce crystal growth of the nano-scale
particles of the target layer and maintain the substrate at a temperature below the temperature of the target layer.

US Pat. No. 9,064,674

LOW TEMPERATURE PLASMA PROBE AND METHODS OF USE THEREOF

Purdue Research Foundatio...

1. A low temperature plasma probe, the probe comprising:
a hollow body having an open distal end;
a discharge gas inlet port coupled to the body such that gas may be injected through the port and into the body; and
an electrode at least partially disposed within the body that generates an electric field;wherein the probe is configured such that injected gas interacts with the electric field to form a low temperature plasma
that is ejected from the distal end of the body by the electric field produced by the electrode.

US Pat. No. 9,200,648

FLUID CONTROL VALVE SYSTEMS, FLUID SYSTEMS EQUIPPED THEREWITH, AND METHODS OF USING

Purdue Research Foundatio...

1. A method of operating a fluid control valve system comprising a bi-directional check valve assembly having a movable member
that is movable with a pilot valve assembly between a closed position that checks flow of a working fluid through the bi-directional
check valve assembly and an open position that allows the working fluid to flow through the bi-directional check valve assembly
between first and second fluid ports thereof, the method comprising:
controlling a pressure of at least one pilot fluid within the pilot valve assembly to enable the movable member of the bi-directional
check valve assembly to selectively check flow of the working fluid flowing from the first fluid port to the second fluid
port or check flow of the working fluid flowing from the second fluid port to the first fluid port;

selectively supplying the at least one pilot fluid at a first pressure to a first pilot chamber of the pilot valve assembly
and supplying the at least one pilot fluid at a second pressure to a second pilot chamber of the pilot valve assembly to check
flow of the working fluid flowing from the first fluid port to the second fluid port while the movable member of the bi-directional
check valve assembly is in the closed position; and

selectively supplying the at least one pilot fluid at the second pressure to the first pilot chamber of the pilot valve assembly
and supplying the at least one pilot fluid at the first pressure to the second pilot chamber of the pilot valve assembly to
check flow of the working fluid flowing from the second fluid port to the first fluid port while the movable member of the
bi-directional check valve assembly is in the closed position thereof.

US Pat. No. 9,166,228

METHOD OF EXPLOITING PARTICLE MORPHOLOGY TO OPTIMIZE GRANULAR STRUCTURE AND CHARGE/DISCHARGE PERFORMANCE OF LITHIUM ION BATTERY CATHODES

PURDUE RESEARCH FOUNDATIO...

1. A method of forming a high-capacity, high-rate lithium ion battery cathode material, comprising:
A) providing a plurality of synthesized electrochemically active plate-shaped nanoparticles;
B) adding a plurality of appropriately sized diluent particles to the electrochemically active plate-shaped nanoparticles
to form a mixed suspension;

C) removing any liquid from the suspension to form a composite material, thereby introducing steric defects between the electrochemically
active plate-shaped nanoparticles; and

D) processing the composite material to form a high-capacity, high-rate lithium ion battery cathode material, wherein the
processing step comprises: curing the composite material, and densifying the composite material, and the densifying step comprises
further introducing steric defects between the electrochemically active plate-shaped nanoparticles by passing the composite
material through a roll press,

said composite material having column heights limited to twice the thickness of the electrochemically active plate-shaped
nanoparticles in the [010] direction.

US Pat. No. 9,081,003

SYSTEMS AND METHODS FOR TESTING DRUGS AND DRUG DELIVERY SYSTEMS

Purdue Research Foundatio...

1. A fluidic system for performing tests on a three-dimensional (3D) cellular structure, comprising:
a bottom panel disposed beneath said top panel, said bottom panel defining;
a reservoir open at opposite ends for flowing a fluid therethrough and sized to contain the 3D cellular structure;
at least one side channel flanking said reservoir and coextensive with at least a portion of a length of said reservoir, said
at least one side channel open at its opposite ends for flowing a fluid therethrough; and

a side wall between said reservoir and a corresponding one of said at least one side channel, said side wall defining openings
for fluid communication between said reservoir and said corresponding side channel, said openings sized to simulate interstitial
transport to and from a lymphatic vessel of a living animal;

a top panel disposed above said bottom panel and defining a top channel open at opposite ends for flowing a fluid therethrough,
said top channel at least partially coincident with said reservoir; and

a porous membrane disposed between said top channel and said reservoir at least where said channels are coincident, said porous
membrane having pores sized to mimic transvascular transport through the endothelium of a blood vessel of the living animal.

US Pat. No. 9,173,919

COLLAGEN-TARGETED NANOPARTICLES

PURDUE RESEARCH FOUNDATIO...

1. A composition comprising at least one collagen binding polypeptide covalently bound to a polymeric nanoparticle, wherein
the polypeptide contains from 7 amino acids to 40 amino acids and wherein the polypeptide does not form a triple helix.

US Pat. No. 9,073,920

SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR

Purdue Research Foundatio...

1. A compound of the formula

or a pharmaceutically acceptable salt thereof, wherein:
R6 is halo, hydroxy or a derivative thereof, thio or a derivative thereof, or amino or a derivative thereof;

RN is heteroalkyl, heterocyclyl, heterocyclyl-alkyl, arylalkyl, or heteroarylalkyl;

RN1 is hydrogen, heteroalkyl, heterocyclyl, heterocyclyl-alkyl, arylalkyl, or heteroarylalkyl;

RA and RD each represent 4 substituents, each independently selected from the group consisting of hydrogen, hydroxy and derivatives
thereof, amino and derivatives thereof, thio and derivatives thereof, and alkyl, alkenyl, alkynyl, cycloalkyl, heteroalkyl,
cycloheteroalkyl, cycloheteroalkenyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; and

W is O or S.

US Pat. No. 9,263,166

SHELL ACTIVATED SINTERING OF CORE-SHELL PARTICLES

Purdue Research Foundatio...

1. A sintered structure comprising:
a sintered core-shell compact comprised of a plurality of core-shell particles sintered at an annealing temperature, each
of the plurality of core-shell particles having a core material surrounded by a shell material prior to annealing, the shell
material being a metal material that diffuses faster than the core material at the annealing temperature, the shell material
being discontinuous in the sintered core-shell compact making the sintered core-shell compact behave electrically as a semiconductor
and not a metal;

wherein the sintered core-shell compact includes a plurality of sintered interfaces between the core-shell particles that
are in physical contact.

US Pat. No. 9,225,964

FIGURE-GROUND ORGANIZATION OF 3-D SCENES

PURDUE RESEARCH FOUNDATIO...

1. A method for locating objects in a pair of two-dimensional images of a three-dimensional scene taken by an imaging device
having two image capture planes, where the scene includes a floor, the method comprising:
recovering a 3-D point P for each of a plurality of points p that appear in both of the two-dimensional images;
estimating a 3-D orientation of the floor, a 3-D orientation of the image capture planes, and a height of the image capture
planes from the floor;

generating a projection C onto a plane parallel to the floor of the collection of points P that do not represent points on
the floor;

partitioning the projection C into regions representing objects; fitting one or more symmetric figures to the points in C
around the identified regions; and generating an output signal that encodes the one or more symmetric figures.

US Pat. No. 9,221,733

METHODS AND SYSTEMS USEFUL FOR DRYING ETHANOL

Purdue Research Foundatio...

1. A method of dehydrating an ethanol water mixture comprising,
a. contacting an ethanol:water mixture of at least 80% w/w ethanol with a first end of a column containing a bed of spherically
shaped pearled starch particles; and

b. removing a dehydrated ethanol product of at least 99% ethanol from a second end of the column.

US Pat. No. 9,140,853

ALL SILICON OPTICAL TRANSISTOR

Purdue Research Foundatio...

1. An optical device, comprising:
an optical cavity formed on a semiconductor substrate;
a first light guide formed on the semiconductor substrate and optically coupled to the optical cavity by a first optical coupling
strength;

a second light guide formed on the semiconductor substrate, the second light guide having a supply port and an output port,
the second light guide optically coupled to the optical cavity by a second optical coupling strength, the first optical coupling
strength stronger than the second optical coupling strength, wherein the second light guide and the optical cavity cooperate
to form a filter for light flowing from the supply port to the output port, the filter having a stop band; and

wherein the first coupling strength is selected such that a first optical signal on the first light guide having a first strength
causes a first shift in the stop band such that a first wavelength is within the stop band, and wherein the second coupling
strength is selected such that a second optical signal on the second light guide having the first strength causes a second
or no shift in the stop band such that the first wavelength is outside of the stop band.

US Pat. No. 9,408,555

SUPERSENSITIVE LINEAR PRESSURE TRANSDUCER

Indiana University Resear...

1. A microfabricated variable capacitor, comprising:
a stator including a plurality of electrically conductive plates each spaced apart from one another, each said pair of adjacent
plates forming a channel between, each of said plates being in a first common electrical communication;

a rotor including a plurality of electrically conductive blades, said rotor being suspended relative to said stator such that
each of said blades is received within a corresponding one of said channels and each said blade includes an area that overlaps
with an area of an adjacent said plate, each of said blades being in a second common electrical communication;

a flexible diaphragm; and
a suspension system for flexibly coupling said rotor and said diaphragm, said system configured and adapted to apply a load
from the diaphragm to the stator in one direction and unable to substantially apply a load from the diaphragm to the stator
in another direction;

wherein the capacitance between the first electrical communication and the second electrical communication varies in correspondence
to the overlapping areas between each said blade and an adjacent plate.

US Pat. No. 9,253,973

CRAWLING ARTHROPOD INTERCEPTING DEVICE AND METHOD

Purdue Research Foundatio...

1. A bed bug intercepting device for placement under a support leg of furniture or other object toward or from which bed bugs
travel, comprising an upstanding, exterior climbable surface that bed bugs can climb and first and second pitfall traps disposed
inwardly of the climbable exterior surface for trapping bed bugs, wherein the first pitfall trap comprises a bait-free inner,
support-leg receiving receptacle for receiving the support leg of furniture or other object wherein the inner receptacle is
bounded by an upstanding peripheral surface that has a surface roughness which is slippery to prevent bed bugs from climbing
out and the second pitfall trap comprises a bait-free outer receptacle wherein the outer receptacle includes upstanding inner
and outer peripheral surfaces that form the outer receptacle therebetween and that each have a surface roughness which is
slippery to prevent bed bugs from climbing out, wherein bed bugs are trapped in the inner receptacle or outer receptacle as
a result of being unable to climb out and wherein the inner receptacle includes a bottom surface on which the support leg
is received such that bed bugs traveling from the furniture or other object are trapped in the inner receptacle and bed bugs
traveling toward the furniture or other object are trapped in the outer receptacle.

US Pat. No. 9,206,193

SUBSTITUTED NORINDENOISOQUINOLINES, SYNTHESES THEREOF, AND METHODS OF USE

PURDUE RESEARCH FOUNDATIO...

1. A process for preparing a compound of the formula
or a pharmaceutically acceptable salt thereof,wherein
R is dimethylamino, pyrrolidin-1-yl, 1H-imidazolyl, 4-methylpiperazin-1-yl, 4-morpholino, or N,N,N?-trimethylethylenediamino;
the process comprising the step of treating a compound of formula

with a compound of formula

and an acid; wherein
R10 is alkyl; and

P is an aldehyde or protected acetal.

US Pat. No. 9,206,225

MATERIALS AND METHODS FOR ISOLATING PHOSPHOPEPTIDES

Purdue Research Foundatio...

1. A method for enriching for a phosphopeptide, comprising steps of:
providing a solid support and a composition for the recovery of phosphopeptides, said composition including: a soluble synthetic
nanopolymer; a metal or a metal oxide, wherein said metal or metal oxide has an affinity for at least one phosphorylated residue
in a phosphopeptide; a first functional group that chelates with the metal or the metal oxide; and a second functional group
that conjugates to the solid support, wherein the first functional group and the second functional groups are attached to
the soluble synthetic nanopolymer;

obtaining a sample wherein the sample includes at least one phosphopeptide; and
contacting the sample with the composition.

US Pat. No. 9,173,041

ENHANCING PERCEPTION OF FREQUENCY-LOWERED SPEECH

PURDUE RESEARCH FOUNDATIO...

1. A sound processing device system configured to assist a hearing-impaired human listener recognize sounds, the sound processing
device system comprising:
a memory device system; and
a data processing device system communicatively connected to the memory device system, the data processing device system configured
by a program stored in the memory device system at least to:

receive an input audio signal; and
generate an output audio signal at least by transposing and causing a negative rank ordering of frequency of at least a portion
of the input audio signal,

wherein the input audio signal is a first portion of an input audio signal stream, wherein the output audio signal is a first
portion of an output audio signal stream, and wherein the data processing device system is configured by the program at least
to:

identify a speech pattern present in the first portion of the input audio signal stream;
generate, in response to the speech pattern being identified as present in the first portion of the input audio signal stream,
the first portion of the output audio signal stream at least by inverting a frequency relationship of at least part of the
first portion of the input audio signal stream;

identify that the speech pattern is not present in a second portion of the input audio signal stream that is other than the
first portion of the input audio signal stream;

generate, in response to identifying that the speech pattern is not present in the second portion of the input audio signal
stream, a second portion of the output audio signal stream without inverting the frequency relationship of at least part of
the second portion of the input audio signal stream, the second portion of the output audio signal stream being other than
the first portion of the output audio signal stream;

identify that the first portion of the input audio signal stream exhibits higher energy at a high-frequency range as compared
to a mid-frequency range of the first portion of the input audio signal stream;

cause, by way of at least a gain, an attenuation, or both a gain and an attenuation, and in response to identifying that the
first portion of the input audio signal stream exhibits the higher energy at the high-frequency range, a low-frequency range
of the first portion of the output audio signal stream to be relatively emphasized or de-emphasized as compared to another
frequency range of the first portion of the output audio signal stream or another time segment of the output audio signal
stream to generate a perceptual cue to facilitate distinguishing of similar sounds, the low-frequency range of the first portion
of the output audio signal stream corresponding, prior to the inverting the frequency relationship of the first portion of
the input audio signal stream, to the high-frequency range of the first portion of the input audio signal stream;

identify a speech pattern present in a third portion of the input audio signal stream that is other than the first portion
of the input audio signal stream and the second portion of the input audio signal stream;

generate, in response to the speech pattern being identified as present in the third portion of the input audio signal stream,
a third portion of the output audio signal stream at least by inverting a frequency relationship of the third portion of the
input audio signal stream, the third portion of the output audio signal stream being other than the first portion of the output
audio signal stream and the second portion of the output audio signal stream;

identify that the third portion of the input audio signal stream exhibits higher energy at a mid-frequency range as compared
to a high-frequency range of the third portion of the input audio signal stream; and

output the third portion of the output audio signal stream without causing, by way of at least a gain, an attenuation, or
both a gain and an attenuation, a low-frequency range of the third portion of the output audio signal stream to be relatively
emphasized or de-emphasized as compared to another frequency range of the third portion of the output audio signal stream
or another time segment of the output audio signal stream, the low-frequency range of the third portion of the output audio
signal stream corresponding, prior to the inverting the frequency relationship of the third portion of the input audio signal
stream, to the high-frequency range of the third portion of the input audio signal stream.

US Pat. No. 9,275,203

METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR PREVENTING SOFTWARE PIRACY AND PROTECTING DIGITAL DOCUMENTS USING SAME

Purdue Research Foundatio...

1. A method for preventing software piracy, the method comprising: specifying a codemark that is intrinsic to a computing
system; providing an application with a first embedded silent guard, the first embedded silent guard including a first portion
that uses the codemark and produces a guarded value that depends on the codemark, the first silent guard further including
a second portion that uses the guarded value as a value for an ordinary program variable in the application and that produces
an output that depends on the guarded value; executing the first and second portions, wherein the second portion causes the
application to malfunction or take another protective action when the guarded value is not equal to an expected value; and
providing a second silent guard embedded in the application.

US Pat. No. 9,252,823

PHASE COMPENSATION FILTERING FOR MULTIPATH WIRELESS SYSTEMS

PURDUE RESEARCH FOUNDATIO...

1. A method for communicating over a wireless link, the method comprising:
a transmitter communicating a predefined test signal via an antenna;
a receiver receiving the test signal;
the receiver determining channel characteristics based on the received test signal;
the receiver communicating the determined channel characteristics;
the transmitter receiving the determined channel characteristics;
the transmitter using the determined channel characteristics in a pre-filter
the transmitter accepting data to transmit;
the transmitter modulating the accepted data;
the transmitter applying the pre-filter to the modulated data using a phase compensation topology based on the channel characteristics
between the transmitter and the receiver; and

the transmitter transmitting the pre-filtered data via an antenna, the frequency response of the pre-filter based on spectral
phase information of the channel such that the frequency response at the receiver is proportional to the magnitude of channel
frequency response.

US Pat. No. 9,227,883

MECHANICALLY ACTIVATED METAL FUELS FOR ENERGETIC MATERIAL APPLICATIONS

Purdue Research Foundatio...

1. A method for making mechanically activated metal fuels for energetic material applications, said method comprising:
mechanically treating micrometer-sized particles of at least one metal with particles of at least one fluorocarbon to form
composite particles containing the at least one metal and the at least one fluorocarbon in unreacted form, wherein the composite
particles contain the at least one metal in a realitve amount of at least about 70 wt. % and wherein the composite particles
contain the at least one fluorocarbon physically encased within particles of the at least one metal.

US Pat. No. 9,164,084

METHODS FOR DETERMINING AGGRESSIVENESS OF A CANCER AND TREATMENT THEREOF

Purdue Research Foundatio...

1. A method for determining aggressiveness of a cancer, the method comprising:
conducting an assay on a lipid droplet in order to detect an amount of a biomarker within the lipid droplet; and
determining aggressiveness of a cancer based upon the amount of the biomarker within the lipid droplet.

US Pat. No. 9,166,907

FAILURE REPAIR SEQUENCE GENERATION FOR NODAL NETWORK

PURDUE RESEARCH FOUNDATIO...

1. A failure repair sequence generation system comprising:
a data processing device system;
a memory device system communicatively connected to the data processing device system and storing a program executable by
the data processing device system, the memory device system storing network information indicating at least a network topology
comprising a plurality of nodes, the plurality of nodes comprising a plurality of root nodes and a plurality of leaf nodes,
each leaf node connected directly or indirectly to at least one root node of the plurality of root nodes, a subset of the
plurality of root nodes indicated by the network information as experiencing failure or indicated by the network information
prior to experiencing failure, a subset of the plurality of leaf nodes indicated by the network information as experiencing
failure or indicated by the network information prior to experiencing failure, and the data processing device system configured
by the program at least to:

acquire, from the memory device system, the network information;
generate a failure repair sequence based at least upon an analysis of at least a portion of the network information, the failure
repair sequence indicating a sequence of node sets in which the node sets are to be repaired, each node set comprising a node
of the plurality of nodes, and the analysis comprising:

(a)
(1) identifying a damage-priority-repair root node of the subset of the plurality of root nodes, which is also a subset of
the plurality of nodes, indicated as experiencing failure that has a greatest number of leaf nodes of the subset of the plurality
of leaf nodes indicated as experiencing failure as compared to at least some other root nodes of the subset of the plurality
of root nodes besides the damage-priority-repair root node,

(2) assigning the identified damage-priority-repair root node a damage-priority-repair position in the sequence of node sets
as compared to the at least some other root nodes of the subset of the plurality of root nodes besides the damage-priority-repair
root node, the damage-priority-repair position being a position in the sequence of node sets that indicates that the identified
damage-priority-repair root node is to be repaired with a higher priority than the at least some other root nodes of the subset
of the plurality of root nodes besides the damage-priority-repair root node, and

(b)
(1) identifying a preventability-priority-repair root node of the subset of the plurality of root nodes indicated as experiencing
failure or prior to experiencing failure that has a connected leaf node of the plurality of leaf nodes that (i) is not indicated
as experiencing failure and (ii) is connected to a fewest number of root nodes as compared to at least some other leaf nodes
of the plurality of leaf nodes not indicated as experiencing failure or prior to experiencing failure,

(2) assigning the identified preventability-priority-repair root node a preventability-priority-repair position in the sequence
of node sets as compared to at least some other root nodes of the subset of the plurality of root nodes besides the preventability-priority-repair
root node, the preventability-priority-repair position being a position in the sequence of node sets that indicates that the
identified preventability-priority-repair root node is to be repaired with a higher priority than the at least some other
root nodes of the subset of the plurality of root nodes besides the preventability-priority-repair root node;

and
storing the generated failure repair sequence in the memory device system.
US Pat. No. 9,155,607

COMPOSITIONS AND METHODS FOR REPAIR OR REGENERATION OF SOFT TISSUE

Purdue Research Foundatio...

1. A biocompatible scaffold substantially free of mineralized bone comprising demineralized cancellous bone substantially
devoid of all osteoinductive factors, the demineralized cancellous bone comprising at least a first region and a second region,
wherein a concentration gradient of crosslinks is configured to extend between the first region to the second region such
that the concentration of the crosslinks in the first region is substantially higher than the concentration of the crosslinks
in the second.

US Pat. No. 9,367,060

INTELLIGENT OPTIMIZATION METHOD AND SYSTEM THEREFOR

Purdue Research Foundatio...

1. A method of optimizing a complex manufacturing process performed on a subject to achieve a plurality of processing objectives,
the method comprising the steps of:
providing a system comprising a graphical user interface, a process module in communication with the graphical user interface,
and an optimization module in communication with the process module, the process module comprising a training module, an empirical
relationships database, an analytical equations database, a heuristic knowledge database, and a process models database, the
optimization module comprising an optimization engine, the system controlling an apparatus adapted to perform a grinding operation;

using the graphical user interface to input into the system at least one processing variable and constraints for the plurality
of processing objectives of the grinding operation, the at least one processing variable comprising at least one parameter
of the grinding operation, operating parameters of the apparatus for performing the grinding operation, and material of the
subject, the plurality of processing objectives comprising at least one of cost of the grinding operation, cycle time of the
grinding operation, and at least one desired property of the subject following the grinding operation, the at least one desired
property comprising at least one of surface roughness, residual stress, and out-of-roundness of the subject;

operating the apparatus to perform a trial of the grinding operation on a specimen of the subject using the at least one processing
variable;

inputting the at least one processing variable used in the trial and empirical data from the trial into the training module,
the training module generating at least one empirical relationship between the at least one processing variable used in the
trial and the empirical data from the trial and storing the at least one empirical relationship in the empirical relationships
database;

using the process module to generate a process model that takes into consideration heuristic knowledge of the grinding operation
stored in the heuristic knowledge database, the at least one empirical relationship stored in the empirical relationships
database, and optionally analytical equations stored in the analytical equations database and relating to the grinding operation;

storing the process model in the process models database; and
operating the optimization module by which the process model is employed to optimize the grinding operation by adjusting the
at least one processing variable and inputting the adjusted processing variable into the apparatus before again operating
the apparatus to perform the grinding operation and achieve the plurality of processing objectives.

US Pat. No. 9,275,620

FLEXIBLE PRINTED CIRCUIT BOARD PICKUP FOR STRINGED INSTRUMENTS AND METHOD OF USING THE SAME

PURDUE RESEARCH FOUNDATIO...

1. A retrofit pickup assembly for a stringed musical instrument, comprising:
an existing pickup assembly having an existing coil wound about a bobbin and a plurality of magnets disposed on the bobbin,
each magnet configured to be placed under a string of the stringed musical instrument; and

a flexible circuit having a plurality of wires and two connectors forming a coil when the connectors are engaged, the flexible
circuit terminating at terminals,

wherein the flexible circuit is configured to be placed over the bobbin and around the coil of the existing pickup assembly
to provide signals from the terminals to a downstream circuit based on movements of the strings of the stringed musical instrument.

US Pat. No. 9,272,468

APPARATUS AND METHOD FOR PRODUCING BIOBASED CARRIERS FROM BYPRODUCTS OF BIOMASS PROCESSING

Purdue Research Foundatio...

1. An apparatus for producing biobased carriers for dispersal of biological and chemical molecules, the apparatus comprising:
a premixer having a first inlet, a first outlet, a cavity configured for receiving a wet coproduct and a binder through the
first inlet, and stirring means within the cavity for premixing the wet coproduct and the binder into a mixture;

a shear mixer having a cylindrical housing and a shear mechanism within the housing, the housing defining an inner surface
and an opening, the shear mechanism comprising a screen covering the opening, a stationary stator, and a rotatable rotor disposed
within the stator, the rotor comprising a shaft and a plurality of rubbing bars mounted and radially spaced around the shaft
to rotate with the shaft, wherein each of the rubbing bars has an arcuate outer surface operable to move in a circumferential
direction along an inner surface of the screen when the shaft rotates and create flow and shear between the plurality of rubbing
bars, the screen, and the inner surface of the housing, force the mixture along the screen in the circumferential direction
thereof, and force and extrude the mixture through the screen and out of the housing in the form of particles, wherein at
least a portion of each respective arcuate outer surface defines a plurality of elements extending up or down from the arcuate
outer surface to enhance shear created between the plurality of rubbing bars, the screen, and the inner surface of the stator;

agglomerator means having an interior chamber sized and configured to receive the particles from the shear mixer and for transforming
the particles into spherical biomass pellets; and

a power source for controlling an operation of the apparatus.

US Pat. No. 9,225,338

SYSTEM AND METHOD FOR REMOVING FAR FIELD LIMITATIONS IN MICROWAVE PHOTONIC ARBITRARY WAVEFORM GENERATORS

PURDUE RESEARCH FOUNDATIO...

1. A photonic waveform generator, comprising:
an input port for receiving an optical signal;
a pulse shaper coupled to the input port and configured to Fourier transform the optical signal and apply a pre-distortion
waveform onto optical spectrum of the optical signal resulting in a shaped optical signal having both optical amplitude and
optical phase spectral shaping;

a dispersive pulse stretcher coupled to the pulse shaper and configured to provide a frequency dependent delay which disperses
the shaped optical signal;

an optical-to-electrical converter coupled to the dispersive pulse stretcher and configured to convert an optical input corresponding
to the dispersed shaped optical signal to an electrical output; and

an output port coupled to the optical-to-electrical converter and configured to output an electrical signal corresponding
to the electrical output,

the pre-distortion waveform of the transformed optical signal removes distortion of the electrical signal that exists in the
absence of the pre-distortion waveform caused by violation of far field limitation between the optical signal and the electrical
signal,

where the shaped optical signal having both optical amplitude and optical phase spectral shaping is given by Ain(?),

where Ain(?) is based on a Fourier transform of the time domain representation an(t) of the shaped optical signal,

where

where aFTM(t) is calculated so that the |AFTM(?=?t/?2|2 is equal to the desired electrical signal waveform,

where AFTM(?) is the Fourier transform of aFTM(t), and


where ?2 is a group delay dispersion of the dispersive pulse stretcher and ?(?) is a propagation constant in a medium in which the
optical signal travels, the medium having length L.

US Pat. No. 9,165,752

SYSTEMS AND METHODS FOR SAMPLE ANALYSIS

Purdue Research Foundatio...

10. A method for analyzing a sample, the method comprising:
introducing a sample to a porous substrate;
applying a discharge from an interaction of a voltage source with a heated gas onto the sample in order to desorb and ionize
the sample from the porous substrate, which passes through the porous substrate and into an inlet of a mass spectrometer,
which is operably associated with the porous substrate to receive ions of the sample, wherein the voltage source comprises
a needle; and

analyzing the ions of the sample in the mass spectrometer.
US Pat. No. 9,506,081

TRANSGENE CONSTRUCT TO IMPROVE FUSARIUM HEAD BLIGHT RESISTANCE IN WHEAT AND BARLEY

The United States of Amer...

1. A method of producing a transgenic plant comprising:
a) transforming a plant cell with a recombinant DNA construct comprising a nucleic acid sequence encoding the wheat ethylene-responsive
transcription factor TaERF7-1 operatively linked to a heterologous promoter effective for expression in said plant cell to
generate a transformed plant cell;

b) growing the transformed plant cell to a transgenic plant, wherein said TaERF7-1 comprises the amino acid sequence of SEQ
ID NO: 1; and wherein said transgenic plant is wheat or barley; and

c) selecting said transgenic plant which exhibit increased resistance to Fusarium head blight in comparison to a non-transformed control plant.

US Pat. No. 9,394,959

DYNAMIC LOAD-ABSORBING MATERIAL AND ARTICLES

PURDUE RESEARCH FOUNDATIO...

1. A composite material for protection of an object from a load, comprising:
a matrix material including at least three sizes of stress-concentrating features, including:
a plurality of first features having a first average characteristic dimension of between about ten microns and about two hundred
microns;

a plurality of second features having a second average characteristic dimension that is at least about one order of magnitude
larger than said first average characteristic dimension; and

a plurality of third features having a third average characteristic dimension that is at least about one order of magnitude
larger than said second average characteristic dimension;

wherein the material proximate to said first, second, and third features progressively buckles upon application of the load,
such that material proximate said third features tends to deform before the deformation of material proximate to said second
and first features, and material proximate said first features tends to deform after the deformation of material proximate
to said second and third features.

US Pat. No. 9,322,953

ENERGY ABSORBING MATERIALS

PURDUE RESEARCH FOUNDATIO...

1. A material, comprising:
an indefinite metamaterial configured to reduce the intensity of surface reflections for a wavelength,
wherein a substantially planar interface surface of the material has a surface roughness with a characteristic dimension in
a first direction perpendicular to the surface, the characteristic dimension substantially equal to the wavelength, and a
correlation length L of the roughness in a second direction parallel to the surface is smaller than the wavelength, the correlation
length L defined as the solution to the equation Ch(L)=Ch(0)/e, where e is 2.7182818, and Ch is defined as Ch(??)=, where ? is a two dimensional vector representing position on the surface and h is the height of the surface
in the first direction with respect to an average height of the surface in the first direction.

US Pat. No. 9,212,981

FEEDBACK SYSTEM AND METHOD FOR ASSESSING FIXATION AND STABILITY OF IMPLANTABLE LEADS

Purdue Research Foundatio...

1. A lead fixation and stability feedback assembly for testing stability and anchoring of a fixation tip of a distal end of
an implantable lead to a tissue, comprising:
a first member including a first coupling arrangement configured to couple to a proximal end of an implantable lead, wherein
the proximal end of the implantable lead is coupled to a distal end of the implantable lead configured to be anchored to a
tissue, first coupling arrangement including a lead clamp assembly configured to translate one or more of a mechanical force
and a magnetic force to grip the proximal end of the implantable lead; and

a second member including a second coupling arrangement configured to couple the first member to the second member, the second
coupling arrangement configured to decouple the second member from the first member when a predetermined force is applied
to pull the second member away from the first member to thereby test the anchoring of the distal end of the implantable lead
to the tissue.

US Pat. No. 9,341,629

SYNTHESIS AND COMPOSITION OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR THE TARGETED IMAGING OF TUMORS

Purdue Research Foundatio...

1. A kit comprising a compound having the formula:

or a pharmaceutically acceptable salt thereof,
or isotopes thereof, wherein:
X is an single amino acid or a single amino acid derivative thereof, wherein the single amino acid or single amino acid derivative
contains an —OH, —NH2, or —SH functional group, and

Y is a dye that has a fluorescence excitation and emission spectra in the near infra red range, wherein Y is represented by
the formula:


wherein, X? is independently selected from the group consisting of O, S, N and C, and
R? is independently selected from the group consisting of CH2 and CH2CH2,

and the compound maintains or enhances the fluorescence of the dye, Y.

US Pat. No. 9,211,539

VARIABLE VOLUME MIXING AND AUTOMATIC FLUID MANAGEMENT FOR PROGRAMMABLE MICROFLUIDS

Purdue Research Foundatio...

1. A programmable lab-on-a-chip (PLoC) arrangement, comprising:
a fluid channel configured to receive a first fluid from a first inlet and a second fluid from a second inlet;
a mixer connected to the fluid channel, the mixer including a mixer channel configured to receive a volume of the first fluid
and a volume of the second fluid from the fluid channel, the mixer channel defining a mixer capacity, wherein the mixer is
(i) configured to mix the volume of the first fluid and the volume of the second fluid in order to provide a mixture of the
first fluid and the second fluid when the combined volume of the first fluid and the second fluid is less than the mixer capacity,
and (ii) further configured to mix the volume of the first fluid and the volume of the second fluid in order to provide a
mixture of the first fluid and the second fluid when the combined volume of the first fluid and the second fluid is equal
to the mixer capacity; and

an air purging arrangement disposed in the mixer channel and configured to purge a volume of air from the mixer channel when
the volume of air is positioned between the volume of the first fluid and the volume of the second fluid in the mixer channel,
the air purging arrangement including a vent orthogonally oriented to a direction of flow of the fluids in the PLoC and including
a membrane configured to allow passage of gas and block passage of liquids.

US Pat. No. 9,068,949

SYSTEM AND METHOD FOR MULTIPLEX SPECTROSCOPIC IMAGING

Purdue Research Foundatio...

1. A system for measuring a sample, the system comprising:
a) an illumination source adapted to provide electromagnetic radiation pulses at a selected temporal frequency;
b) a microscope adapted to focus the provided electromagnetic radiation onto the sample, so that resultant electromagnetic
radiation is produced by an interaction of the provided electromagnetic radiation with the sample;

c) a plurality of optical sensors;
d) a disperser adapted to disperse wavelengths of the resultant electromagnetic radiation onto the plurality of optical sensors;
and

e) a plurality of resonant amplifiers corresponding to respective ones of the optical detectors, each resonant amplifier operative
to amplify signals having the selected temporal frequency.

US Pat. No. 9,386,817

DYNAMIC LOAD-ABSORBING MATERIALS AND ARTICLES

PURDUE RESEARCH FOUNDATIO...

1. A double-shell helmet, comprising:
an outer shell;
an impact absorbing material layer affixed to the outer shell on a first side of the impact absorbing material layer, the
impact absorbing material layer including

a matrix material including at least three sizes of stress-concentrating features and further including:
a plurality of first features having a first average characteristic dimension of between ten microns and two hundred microns,
a plurality of second features having a second average characteristic dimension that is at least one order of magnitude larger
than said first average characteristic dimension, and

a plurality of third features having a third average characteristic dimension that is at least one order of magnitude larger
than said second average characteristic dimension,

wherein the material proximate to said first, second, and third features progressively buckles upon application of a load,
such that material proximate said third features tends to deform before the deformation of material proximate to said second
and first features, and material proximate said first features tends to deform after the deformation of material proximate
to said second and third features;

an inner shell affixed to the impact absorbing material layer on a second side of the impact absorbing material layer opposite
the first side of the impact absorbing material layer; and

a foam layer affixed to the inner shell.

US Pat. No. 9,388,211

N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF

Purdue Research Foundatio...

1. A compound of the formula

or a pharmaceutically acceptable salt, hydrate, or solvate thereof,
wherein:
m is an integer from 0 to about 6;
R6 is selected from the group consisting of heteroaryl, heteroaryloxy, heteroarylamino, heteroarylalkylaminoalkylamino, heterocyclyl,
heterocyclylamino, amino, alkylamino, dialkylamino, trialkylammonium, bis(hydroxyalkyl)amino, and hydroxyalkylaminoalkylamino,
wherein each of heteroaryl, heteroaryloxy, and heteroarylamino, heteroarylalkylaminoalkylamino, heterocyclyl, and heterocyclylamino
is optionally substituted;

Ra represents 1-4 substituents each of which is independently selected from the group consisting of hydrogen, halo, hydroxy,
optionally substituted alkyl, optionally substituted alkoxy, cyano, nitro, optionally substituted alkylthio, optionally substituted
alkylsulfonyl, carboxylic acid, and sulfonic acid; or Ra represents 2-4 substituents where 2 of said substituents are adjacent substituents and are taken together with the attached
carbons to form an optionally substituted heterocycle, and where any remaining substituents are each independently selected
from the group consisting of hydrogen, halo, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, cyano,
nitro, optionally substituted alkylthio, optionally substituted alkylsulfonyl, carboxylic acid, and sulfonic acid; and

Rd represents 1-4 substituents each of which is independently selected from the group consisting of hydrogen, halo, hydroxy,
optionally substituted alkyl, optionally substituted alkoxy, cyano, nitro, optionally substituted alkylthio, optionally substituted
alkylsulfonyl, carboxylic acid, and sulfonic acid; or Rd represents 2-4 substituents where 2 of said substituents are adjacent substituents and are taken together with the attached
carbons to form an optionally substituted heterocycle, and where any remaining substituents are each independently selected
from the group consisting of hydrogen, halo, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, cyano,
nitro, optionally substituted alkylthio, optionally substituted alkylsulfonyl, carboxylic acid, and sulfonic acid, and

wherein at least one of Ra or Rd is not hydrogen.

US Pat. No. 9,359,619

BIOMASS LIQUEFACTION PROCESSES, AND USES OF SAME

Purdue Research Foundatio...

1. A method for liquefaction of solid lignocellulosic biomass, comprising:
(a) contacting the solid lignocellulosic biomass with a dicarboxylic acid for a period of time and under conditions effective
to form an acidic mixture containing liquefied lignocellulosic biomass components and unliquefied lignocellulosic biomass
components, wherein said contacting is conducted in the presence of from about 0.1% to 2% of the dicarboxylic acid relative
to the lignocellulosic biomass on a dry weight basis, wherein said contacting is conducted with said dicarboxylic acid in
an aqueous medium, and wherein the aqueous medium is at least 80% by weight aqueous;

(b) neutralizing the acidic mixture to form a neutralized mixture containing the liquefied lignocellulosic biomass components
and unliquefied lignocellulosic biomass components, wherein said liquefied lignocellulosic biomass components in the neutralized
mixture comprise phenols; and

(c) after said neutralizing, enzymatically hydrolyzing the unliquefied lignocellulosic biomass components in the presence
of at least a portion of the liquefied lignocellulosic biomass components, wherein said enzymatically hydrolyzing is conducted
sufficiently to form a flowable enzyme-hydrolyzed composition fluid having a yield stress of less than about 1000 Pascals,
and wherein said enzymatically hydrolyzing is conducted in the presence of a cellulase enzyme at a level of 3 Filter Paper
Units or less per gram of glucan in the solid lignocellulosic biomass.

US Pat. No. 9,160,333

CAPACITIVE MICROELECTROMECHANICAL SWITCHES WITH DYNAMIC SOFT-LANDING

PURDUE RESEARCH FOUNDATIO...

1. A microelectromechanical system (MEMS)-based electrical switch system, comprising:
at least one electrical switch, comprising:
a moveable electrode,
a dielectric layer disposed adjacent the moveable electrode on a first side of the dielectric layer and spaced apart from
the moveable electrode when the switch is in an inactivated position and in contact with the moveable electrode when the switch
is in an activated position, and

a substrate attached to the dielectric layer on a second side opposite to the first side;
at least one voltage source coupled to the switch; and
at least one resistive element positioned in series between the switch and the voltage source,
the resistive element is configured to brake movement of the moveable electrode prior to coming in contact with the dielectric
layer when the voltage source causes the switch to be switched between the inactivated state and the activated state;

the moveable electrode is formed from a plurality of electrically connected structures that are spaced from one another and
held together by an insulator, the electrically connected structures selected from the group consisting of:

a) cylindrical structures; and
b) spherical structures arranged in strips.

US Pat. No. 9,498,218

SYSTEM AND METHOD FOR ATTACHING SOFT TISSUE TO AN IMPLANT COMPRISING A NANOTEXTURED SURFACE

Purdue Research Foundatio...

1. A kit for repairing a diarthrodial joint, the kit comprising:
a metal implant construct, the construct comprising
a metal implant comprising a porous region, wherein the porous region exhibits a nano-textured surface;
a calcified material layer coating the nano-textured surface;
an extender graft comprising a naturally occurring extracellular matrix, and a mesh member coupled to the naturally occurring
extracellular matrix; and

a scaffold element, wherein the scaffold element comprises a biocompatible polymer matrix and a bioactive agent.

US Pat. No. 9,187,824

RAPID SYNTHESIS OF GRAPHENE AND FORMATION OF GRAPHENE STRUCTURES

Purdue Research Foundatio...

1. A method of graphene film synthesis, the method comprising:
a. providing a copper foil,
b. placing the foil in a microwave plasma chemical vapor deposition chamber,
c. evacuating the chamber to approximately 2 Torr,
d. providing hydrogen gas to the chamber,
e. exposing the foil to plasma,
f. providing methane gas maintaining approximately 10 Torr in the chamber,
wherein the foil is supported by a ceramic stud elevating the foil above a molybdenum puck.

US Pat. No. 9,190,269

SILICON-ON-INSULATOR HIGH POWER AMPLIFIERS

PURDUE RESEARCH FOUNDATIO...

1. A method comprising:
fabricating a power amplifier in a first silicon layer of a silicon-on-insulator (SOI) substrate, wherein the SOI substrate
comprises the first silicon layer, a second silicon layer, and a buried oxide layer disposed between the first and second
silicon layers;

removing at least some of the second silicon layer from the SOI substrate, after fabricating the power amplifier; and
securing the SOI substrate, after removing at least some of the second silicon layer, to an electrically non-conductive and
thermally conductive substrate;

wherein the power amplifier comprises:
a plurality of transistors formed in the first silicon layer of the SOI substrate such that the plurality of transistors are
each electrically isolated from one another within the SOI substrate; and

a plurality of biasing networks, each biasing network being configured to dynamically bias at least one of the plurality of
transistors;

wherein the plurality of transistors are electrically coupled in a series stack and an output of the power amplifier is provided
across the series stack.

US Pat. No. 9,184,036

SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE

PURDUE RESEARCH FOUNDATIO...

1. A system for analyzing a sample, the system comprising:
a mass spectrometry probe that generates sample ions by inductive charging, the probe comprising a spray emitter and a high
voltage source that externally applies an electric field to the spray emitter;

a discontinuous atmospheric interface; and
a mass analyzer;
wherein the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

US Pat. No. 9,101,655

METHODS AND COMPOSITIONS FOR TREATING MAMMALIAN NERVE TISSUE INJURIES

Purdue Research Foundatio...

1. A method for treating an injury to nerve tissue of a mammalian patient, the method comprising administering an effective
amount of a composition comprising polyethylene glycol to the patient so that the polyethylene glycol is delivered via the
patient's vascular system to the site of the injured nerve tissue and wherein the polyethylene glycol is about 15% to about
50% by weight in the composition.
US Pat. No. 9,393,262

CHITOSAN DERIVATIVES FOR INACTIVATION OF ENDOTOXINS AND SURFACE PROTECTION OF NANOPARTICLES

PURDUE RESEARCH FOUNDATIO...

1. A nanoparticle comprising a non-covalent, electrostatic complex between a poly(amidoamine) dendrimer (PAMAM dendrimer)
and a zwitterionic chitosan derivative having an anhydride to amine (An/Am) ratio of 0.3 to 0.7, wherein (1) the zwitterionic
chitosan derivative was synthesized by partial amidation of a chitosan with succinic anhydride and (2) the size of the nanoparticle
is between 250 nm and about 500 nm.

US Pat. No. 9,190,600

LARGE-DEFLECTION MICROACTUATORS

Purdue Research Foundatio...

1. An actuator, comprising:
a) a plurality of S-drives, each having a first end and a second end, the S-drives mechanically connected in series at their
first ends and second ends alternately, each S-drive including:

i) four piezoelectric elements disposed substantially in a respective common plane of the S-drive and arranged as a first
and a second pair of the piezoelectric elements, the piezoelectric elements in each pair spaced apart and mechanically coupled
at their ends, and the first and second pairs mechanically connected in series to define the first and second ends of the
S-drives; and

ii) first and second electrodes arranged so that voltage applied to the first electrode causes deformation of a first piezoelectric
element of the first pair and a second piezoelectric element of the second pair, and voltage applied to the second electrode
causes deformation of a second piezoelectric element of the first pair and a first piezoelectric element of the second pair;

iii) one or more common electrode(s), each common electrode arranged opposite the first electrode or opposite the second electrode
in a direction substantially normal to the respective common plane; and

b) a controller adapted to selectively apply voltage of a first polarity between the first electrode and at least one of the
common electrode(s) facing the first electrode, and contemporaneously apply voltage of a second polarity opposite to the first
polarity between the second electrode and at least one of the common electrode(s) facing the second electrode, so that each
of the S-drives deflects substantially in the respective common plane and substantially in a common deflection direction.

US Pat. No. 9,188,563

PERFORATED MOS STRUCTURE FOR SINGLE BIOMOLECULE DETECTION

PURDUE RESEARCH FOUNDATIO...

1. A perforated metal oxide semiconductor (MOS) sensor, comprising:
a sensing portion including
a doped substrate;
a highly doped region disposed within the substrate;
an oxide layer disposed on the substrate;
a first metal portion coupled to the highly doped region;
a first terminal coupled to the first metal portion;
a poly-silicon layer disposed within the oxide layer;
a second metal portion coupled to the poly-silicon layer;
a second terminal coupled to the second metal portion;
a nanochannel formed through the sensing portion configured to allow a solution containing particles to pass through the perforated
MOS sensor, the doped substrate, and the poly-silicon layer, wherein the first terminal and the second terminal are configured
to measure electrical parameters representative of change of electrical characteristics of the solution as a particle passes
through the perforated MOS sensor.

US Pat. No. 9,279,813

EX VIVO FLOW CYTOMETRY METHOD AND DEVICE

Purdue Research Foundatio...

1. A method of detecting an imaging agent bound to pathogenic cells comprising the steps of:
(i) combining 1) an ex vivo patient sample comprising the pathogenic cells collected from a patient, wherein the ex vivo patient
sample is a body fluid of the patient, and 2) a composition comprising a conjugate of the formula

Ab-X

wherein X is the imaging agent, wherein the imaging agent emits a detectable signal, and
wherein Ab comprises a prostate-specific membrane antigen binding ligand, and wherein the prostate-specific membrane antigen binding
ligand binds to the prostate-specific membrane antigen on the pathogenic cells; and

(ii) detecting, using flow cytometry, the signal from the imaging agent moiety of the conjugate that is bound to the pathogenic
cells, and wherein the conjugate of the formula Ab-X in the method allows quantitation of the pathogenic cells at about 1 to about 10 cells per two milliliters of the ex vivo
patient sample.

US Pat. No. 9,194,107

REGENERATIVE HYDRAULIC SYSTEMS AND METHODS OF USE

Purdue Research Foundatio...

1. A hydraulic system comprising:
at least first and second hydraulic actuators;
multiple sets of hydraulic valves fluidically connected to the first and second hydraulic actuators;
at least first and second variable displacement units each having pumping and motoring modes;
drive shafts associated with the first and second variable displacement units and interconnected with each other such that
the drive shafts are rotatably coupled and cause the first and second variable displacement units to operate in unison;

at least one motor connected to the drive shafts of the variable displacement units for rotating the drive shafts;
at least one reservoir from which the fluid can be drawn by the first and second variable displacement units when operating
in their pumping modes and to which the fluid can be returned by the first and second variable displacement units when operating
in their motoring modes;

a first conduit system containing at least a first hydraulic valve of each of the sets of hydraulic valves, the first conduit
system selectively fluidically connecting the first variable displacement unit to the first and second hydraulic actuators,
each of the first hydraulic valves selectively fluidically connecting the first variable displacement unit to one of the first
or second hydraulic actuators;

a second conduit system containing at least a second hydraulic valve of each of the sets of hydraulic valves, the second conduit
system selectively fluidically connecting the first and second hydraulic actuators to the reservoir, each of the second hydraulic
valves selectively fluidically connecting one of the first or second hydraulic actuators to the reservoir;

a third conduit system containing at least a third hydraulic valve of each of the sets of hydraulic valves, the third conduit
system selectively fluidically connecting at least the second variable displacement unit to the first and second hydraulic
actuators, each of the third hydraulic valves selectively fluidically connecting the second variable displacement unit to
one of the first or second hydraulic actuators, the third conduit system being adapted to transfer the fluid between the first
and second hydraulic actuators;

first valve means for selectively fluidically isolating the first conduit system from the third conduit system and selectively
fluidically connecting the first conduit system to the third conduit system; and

second valve means for selectively fluidically isolating the second conduit system from the third conduit system and selectively
fluidically connecting the second conduit system to the third conduit system;

wherein the hydraulic system is operable to:
transfer energy when one of the first and second hydraulic actuators is subjected to a resistive load and the other of the
first and second hydraulic actuators is subjected to an assistive load by transferring the fluid within the other of the first
and second hydraulic actuators to the one of the first and second hydraulic actuators through the third conduit system;

transfer energy when one of the first and second hydraulic actuators is subjected to a resistive load and the other of the
first and second hydraulic actuators is subjected to an assistive load by transferring the fluid from the reservoir to the
one of the first and second hydraulic actuators through the third conduit system while operating the second variable displacement
unit in the pumping mode thereof; and

recover energy when one of the first and second hydraulic actuators is subjected to an assistive load by transferring the
fluid within the one of the first and second hydraulic actuators to the reservoir through the third conduit system while operating
the second variable displacement unit in the motoring mode thereof.

US Pat. No. 9,190,099

HIGHER ORDER STRUCTURED DYES WITH ENHANCED OPTICAL FEATURES

PURDUE RESEARCH FOUNDATIO...

1. A multimer of an organic dye compound, the multimer comprising at least two molecules of the organic dye compound covalently
coupled together through a linker having the general formula:

wherein R is a halogen and where m and p are numbers from 2-20 indicating a carbon chain in which heteroatoms such as S, O
and N can be included, and where B, C, X, Y, E, G, J, L B?, C?, X?, Y?, E?, G?, J?, and L? are each independent hydrogen,
deuterium, or halogen substituents, and where Z is CH or N.

US Pat. No. 9,190,135

ORGANIC FERROELECTRIC MATERIAL BASED RANDOM ACCESS MEMORY

PURDUE RESEARCH FOUNDATIO...

1. A memory cell with non-destructive read out feature comprising:
a control transistor; and
a memory transistor, a drain of the memory transistor electrically connected to a gate of the control transistor, wherein
a channel of the memory transistor comprises a semiconductor and a gate oxide of the memory transistor comprises a ferroelectric;

wherein the control transistor is in depletion mode when no external bias is applied to either a word line or bit line for
the memory cell with a sense line being grounded.

US Pat. No. 9,096,541

INHIBITION OF MEMAPSIN 1 CLEAVAGE IN THE TREATMENT OF DIABETES

Oklahoma Medical Research...

1. A method of inhibiting memapsin 1 activity comprising contacting a memapsin 1 enzyme with a compound having a formula:
wherein R5 is:
wherein:
R9 is hydrogen or halo;

R10 is alkyl(C?4);

R6 is hydrogen, alkyl(C?8), aralkyl(C?8), or a substituted version of the alkyl(c?8) or aralkyl(C?8) groups; or a halogen; and

R7 is:



R8 is hydrogen, alkyl(C?8), or

wherein: R12 and R13 are each independently hydrogen, alkyl(C?8), or alkylsulfonyl(C?8),

wherein (i) if R9 is hydrogen, then R8 must be hydrogen or alkyl(C?8), and (ii) if R8 is


 then R9 must be halo, and one or both of R12 and R13 must be hydrogen,
or a pharmaceutically acceptable salt or tautomer.

US Pat. No. 9,068,123

MULTIPURPOSE COKE PLANT FOR SYNTHETIC FUEL PRODUCTION

Purdue Research Foundatio...

1. A method for producing coke, comprising:
providing a recovery coke oven capable of operation over a range of temperatures and a processing plant in fluid communication
with the coke oven;

providing a first coal from a first source;
providing a second coal from a second source different than the first source;
analyzing the volatile gas content of the first coal within the range of temperatures;
selecting a temperature from the range of temperatures that will release a desired concentration of at least one volatile
gas;

supplying a blend of the first coal and the second coal into the coke oven;
pyrolizing at the selected temperature the blend of the first coal and the second coal in the coke oven to release the gas;
and

providing the released gas to the processing plant.

US Pat. No. 9,359,685

FORMATION OF CONDUCTIVE POLYMERS USING NITROSYL ION AS AN OXIDIZING AGENT

Purdue Research Foundatio...

1. A method of forming a conductive polymer deposit on a substrate, the method comprising:
preparing a composition comprising monomers of the conductive polymer and a nitrosyl precursor, the nitrosyl precursor being
a nitrite;

contacting the substrate with the composition so as to allow formation of nitrosyl ion from the nitrite only on the exterior
surface of the substrate, the substrate comprising a proton-donating surface or a proton-preloaded surface that serves as
the only proton source used to convert the nitrite to the nitrosyl ion; and

allowing the monomers to polymerize into the conductive polymer, the polymerization being initiated by the nitrosyl ion generated
at the exterior surface of the substrate, and the conductive polymer being deposited only on the exterior surface of the substrate.

US Pat. No. 9,334,505

USING CORNGRASS1 TO ENGINEER POPLAR AS A BIOENERGY CROP

PURDUE RESEARCH FOUNDATIO...

1. A method of producing a poplar plant with decreased lignin content as compared to a control poplar plant, comprising:
inserting a Zea mays Cg1 gene into a Cg1 construct, wherein the Cg1 gene targets a gene having an SBP box;

introducing the Cg1 construct into a cell to yield a transformed cell;
generating a transgenic poplar plant from the transformed cell; and
growing the transgenic poplar plant, wherein the transgenic poplar plant exhibits decreased lignin content as compared to
the control poplar plant.

US Pat. No. 9,222,878

METHOD AND DEVICE FOR OPTICAL IMAGING WITH A RESONANT AMPLIFIER ASSEMBLY

Purdue Research Foundatio...

1. An optical imaging apparatus comprising:
an optical signal source configured (i) to generate an optical signal including a carrier signal and an imaging signal, and
(ii) to guide said optical signal to a sample;

an optical signal detector apparatus configured (i) to detect a modified optical signal from said sample, and (ii) to generate
an electrical image signal based on said modified optical signal, said electrical image signal including a background component
and a modulated image signal corresponding to an image of said sample; and

a resonant amplifier assembly electrically coupled to said optical signal detector apparatus and configured (i) to isolate
said modulated image signal from said background component, (ii) to amplify said modulated image signal, and (iii) to rectify
said modulated image signal.

US Pat. No. 9,504,047

METHOD AND APPARATUS FOR OPPORTUNISTIC USER SCHEDULING OF TWO-CELL MULTIPLE USER MIMO

Samsung Electronics Co., ...

1. A method for opportunistic user scheduling of a multi-user multiple input multiple output (MIMO) by a base station, the
method comprising:
broadcasting signals through a set of randomly generated beamforming vectors;
receiving channel quality information (CQI) from each of user terminals that receive the broadcasted signals; and
determining a best user set among the user terminals based on the CQI and inter-user interference of the user terminals,
wherein a number of beamforming vectors included in the set of randomly generated beamforming vectors is equal to a number
of user terminals included in the best user set,

wherein the CQI comprises CQI values corresponding to the beamforming vectors, respectively,
wherein each of the CQI values corresponding to the beamforming vectors is determined based on a post processing matrix to
be applied to the broadcasted signals, and an inter-user interference and an out-of-cell interference when a corresponding
beamforming vector is used for transmission,

wherein the post processing matrix for the corresponding beamforming vector is determined to maximize an achievable rate after
post processing with the post processing matrix to be applied to the broadcasted signals when the corresponding beamforming
vector is used for transmission, and

wherein the achievable rate after post processing is calculated based on a signal when the corresponding beamforming vector
is used for transmission, the inter-user interference and the out-of-cell interference when the corresponding beamforming
vector is used for transmission.

US Pat. No. 9,115,748

AXIAL SLIDING BEARING AND METHOD OF REDUCING POWER LOSSES THEREOF

Purdue Research Foundatio...

1. An axial piston machine comprising:
a cylinder block adapted to be rotated about an axis of the axial piston machine;
a plurality of cylindrical bores defined in the cylinder block and surrounding the axis;
a plurality of pistons reciprocably disposed within the cylindrical bores; and
a valve body having a fluid inlet through which a fluid enters the cylindrical bores and a fluid outlet through which the
fluid leaves the cylindrical bores as the pistons reciprocate within the cylindrical bores, the fluid forming a fluid film
within an interface between mating surfaces of the cylinder block and the valve body that face each other, the mating surface
of the cylinder block having a sealing land and a bearing land, the machine configured such that the mating surfaces slidably
move relative to each other in a first direction of motion while maintaining the interface therebetween and maintaining bearing
and sealing functions thereat;

wherein a surface profile comprising an oscillatory waveform is located at least either on the sealing land of the cylinder
block or on a portion of the valve body that directly faces the sealing land of the cylinder block, the oscillatory waveform
defining a circular path that is continuous in the first direction of motion, the oscillatory waveform having a peak-to-peak
amplitude of less than one hundred micrometers, the oscillatory waveform producing a hydrodynamic sealing effect sufficient
to provide a sealing function around the fluid inlet, the fluid outlet, and the cylindrical bores that limits fluid leakage
from the fluid film within the interface as the mating surfaces slidably move relative to each other in the first direction
of motion, the oscillatory waveform being a sinusoidal, a triangular, or a sawtooth waveform.

US Pat. No. 9,496,127

DIFFERENTIALLY PUMPED DUAL LINEAR QUADRUPOLE ION TRAP MASS SPECTROMETER

Purdue Research Foundatio...

1. A system comprising:
a first mass spectrometer comprising a first ion trap in a first vacuum chamber;
a second mass spectrometer comprising a second ion trap in a second vacuum chamber; and
a vacuum manifold operably connecting the first and second vacuum chambers such that charged particles travel from the first
vacuum chamber into the second vacuum chamber.

US Pat. No. 9,233,175

METHODS OF IMAGING INFLAMMATORY DISEASES BY LIGANDS CONJUGATED TO FLUORESCENT COMPOUNDS

Purdue Research Foundatio...

1. A method of imaging an inflammatory disease comprising the steps of:
a. administering to a patient in need of an effective amount of a compound capable of binding to an inflammatory cell having
the formula:


or a pharmaceutically acceptable salt or isotope thereof, wherein:
X is an single amino acid or a single amino acid derivative thereof, wherein the single amino acid or single amino acid derivative
contains an —OH, —NH2, or —SH functional group wherein the amino acid of the compound is selected from the group consisting of tyrosine, cysteine,
serine, lysine, a derivative of tyrosine, a derivative of cysteine, a derivative of serine and a derivative of lysine, and

Y is a dye that has a fluorescence excitation and emission spectra in the near infra red range, wherein Y is represented by
the formula:


wherein, X? is independently selected from the group consisting of O, S, N and C, and
R? is independently selected from the group consisting of CH2 and CH2CH2,

and the compound enhances the fluorescence of the dye, Y; and
b. fluorescent imaging of an area of the inflammatory disease in the patient's body where the compound has been bound to an
inflammatory cell.

US Pat. No. 9,184,038

ION FOCUSING

PURDUE RESEARCH FOUNDATIO...

1. An apparatus for focusing ions, the apparatus comprising:
an electrode comprising a cavity;
at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated
by the source is injected into the cavity of the electrode; and

an outlet;
wherein the cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity
are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions
and a distal end of the outlet is open to ambient pressure.

US Pat. No. 9,093,190

SYNTHESIS OF MULTINARY CHALCOGENIDE NANOPARTICLES COMPRISING CU, ZN, SN, S, AND SE

PURDUE RESEARCH FOUNDATIO...

1. A composition of matter comprising a plurality of discrete CZTSSe nanoparticles, said nanoparticles comprising copper,
zinc, tin, and at least one chalcogen species, the composition of matter having the non-stoichiometric chemical formula Cu2.04±0.25Zn0.89±0.19Sn1.11±0.05(S,Se)4 or the non-stoichiometric chemical formula Cu1.48±0.08Zn2.19±0.16Sn0.91±0.03(S,Se)4.

US Pat. No. 9,075,056

REAGENTS AND METHODS FOR PHOSPHORYLATION/DEPHOSPHORYLATION ANALYSES

Purdue Research Foundatio...

1. A reagent for the detection of phosphorylated molecules, the reagent comprising:
a linking core comprising at least one core selected from the group consisting of: a nanopolymer, a dendrimer molecule, and
a core including an amide moiety;

at least one moiety that includes a metal that is directly coupled to the linking core, the metal selected from the group
consisting of: Ti(IV), Zr(IV), Fe(III), Ga(IV), Al(III), Sn(IV), Cu(II), and Zn(II); and

at least one reporter group that is coupled to the linking core, the reporter group being selected from the group consisting
of: biotin, an antibody, a lectin, a thiol, a fluorescent group, a chromophore, a chemiluminescent group and a radioactive
group;

wherein the metal and the at least one reporter group are associated with each other via the linking core and the moieties
that include the metal bind to phosphorylated molecules.

US Pat. No. 9,943,603

COFERONS AND METHODS OF MAKING AND USING THEM

Cornell University, Itha...

1. A therapeutic dimer having:a boronate ester moiety formed from a phenylboronic acid linker element and a cis-1,2 diol binding partner;
a diversity element joined to the phenylboronic acid linker element through a connector; and
a diversity element joined to the cis-1,2 diol binding partner through another connector, wherein the diversity element joined to the cis-1,2 diol binding partner and the diversity element joined to the phenylboronic acid linker each bind to proximate locations on a target molecule, and wherein said diversity element is a molecule having a structure based on one or more of monocyclic scaffolds, bicyclic scaffolds, tetracyclic scaffolds, spiro scaffolds, or combinations thereof linked by a covalent bond forming multicore scaffolds; and wherein said target molecule is (1) G-protein coupled receptors, (2) nuclear receptors, (3) voltage gated ion channels, (4) ligand gated ion channels, (5) receptor tyrosine kinases, (6) growth factors, (7) proteases, (8) sequence specific proteases, (9) phosphatases, (10) protein kinases, (11) bioactive lipids, (12) cytokines, (13) chemokines, (14) ubiquitin ligases, (15) viral regulators, (16) cell division proteins, (17) scaffold proteins, (18) DNA repair proteins, (19) bacterial ribosomes, (20) histone deacetylases, (21) apoptosis regulators, (22) chaperone proteins, (23) serine/threonine protein kinases, (24) cyclin dependent kinases, (25) growth factor receptors, (26) proteasome, (27) signaling protein complexes, (28) protein/nucleic acid transporters, or (29) viral capsids.
US Pat. No. 9,499,854

TYROSINE KINASE BIOSENSORS AND METHODS OF USE

Purdue Research Foundatio...

1. A method for designing peptide substrates phosphorylated by a single target kinase family which, upon phosphorylation,
binds and enhances lanthanide ion sensitization, binding affinity and luminescent lifetime without the need for sensitizing
agents, the method comprising:
(a) curating kinase specific input data sets consisting of validated endogenous sequences for peptide substrates and the target
kinase family interacting partner sequences;

(b) encoding the input data sets from step (a) into positional scoring matrices;
(c) manipulating the positional scoring matrices generated in step (b) to identify positions required for kinase selectivity,
scoring amino acids overrepresented 4 residues upstream and downstream of a phosphorylated residue;

(d) generating a candidate list of peptide sequences based on combinatorial peptide sequences of a result in step (c);
(e) comparing the combinatorial peptide sequences of step (d) to the combinatorial peptide sequences for at least one other
kinase;

(f) using the results of steps (c)-(e), substitute residues at non-selective positions in selections from the candidate list
of peptide sequences from step (e) with terbium binding residues by comparing sequence similarity scores to a known terbium
binding motif; and

(g) screening the selections from the candidate list of peptide sequences with substituted residues from step (f) in vitro
for the ability to bind terbium in a phosphorylation dependent manner.

US Pat. No. 9,369,275

KEY AGREEMENT IN WIRELESS NETWORKS WITH ACTIVE ADVERSARIES

CALIFORNIA INSTITUTE OF T...

1. A network of computers with error correction code configured to transmit keys secretly and securely comprising:
a first computer-based workstation operating as a source node and configured to encode a key into a plurality of distinct
encoded source files, encoding being operatively implemented in one of: a) hardware, b) software, and c) a combination of
a) and b);

a plurality of computer-based workstations operating as a plurality of intermediate nodes and configured to each receive a
distinct encoded source file of the plurality of distinct encoded source files and transmit, to a receiver node, the distinct
encoded source file when requested by the receiver; and

a second computer-based workstation operating as the receiver node and configured to decode the plurality of distinct encoded
source files and retrieve the key, decoding being operatively implemented in one of: a) hardware, b) and/or software, and
c) a combination of a) and b);

wherein the encoding, transmitting and decoding of the key comprise the following steps:
generating the key to be transmitted from the source node to the receiver node,
generating one or more random packets independently and uniformly within the source node,
generating a distinct encoded file for each intermediate node in the network, the encoded file comprising a linear combination
of the key, the one or more random packets that were independently and uniformly generated and corresponding error detection
information,

forwarding each of the distinct encoded files generated by the source node to each corresponding intermediate node of the
plurality of intermediate nodes within the network via a first plurality of intermediate transmission links,

forwarding each of the distinct encoded files, upon request by the receiver node, from the corresponding intermediate node
via a second plurality of intermediate transmission links, and

decoding the key from the plurality of encoded files, the error detection information used to determine if an error was present
in either the intermediate transmission link and/or the intermediate node for a particular encoded file.

US Pat. No. 9,296,131

METHOD OF FORMING A CELLULOSE NANOCRYSTALLINE FILM

Purdue Research Foundatio...

1. A method of forming a substantially uniaxially-oriented, high content cellulose nanocrystal film, the method comprising:
providing a suspension of cellulose nanocrystals extracted from plant biomass;
altering the pH of the suspension to a substantially neutral pH;
shearing the neutralized suspension at a defined shearing rate using a doctor blade;
orienting cellulose nanocrystals of the neutralized suspension in a substantially axial direction;
removing water from the sheared cellulose nanocrystal suspension; and
forming a cellulose nanocrystal film having a substantially uniaxial orientation in the axial direction.

US Pat. No. 9,500,572

SAMPLE DISPENSER INCLUDING AN INTERNAL STANDARD AND METHODS OF USE THEREOF

Purdue Research Foundatio...

1. A fluid dispensing system, the system comprising:
an elongated inlet configured to extend external to the fluid dispensing system, wherein an entirety of only an inner wall
of the elongated inlet comprises an internal standard, the elongated inlet being configured such that fluid introduced to
the elongated inlet must interact with the entirety of the inner wall of the elongated inlet that comprises the internal standard
prior to flowing through an outlet of the fluid dispensing system; and

a dispenser that couples to an external wall of the elongated inlet and controls movement of fluid within the elongated inlet.

US Pat. No. 9,487,877

CONTACT METALLIZATION OF CARBON NANOTUBES

PURDUE RESEARCH FOUNDATIO...

1. A method of metallizing an array of carbon nanotubes, comprising:
fabricating a template including a base conducting layer, a first layer of a material on top of the conductive layer, a second
layer of catalytic material on top of the first layer, and a third layer of the material on top of the second layer;

forming a plurality of pores in the first, second, and third layers;
synthesizing at least one carbon nanotube from the catalytic layer in each of a plurality of pores;
placing the porous template in a solution containing metallic ions after said synthesizing; and
electrodepositing a quantity of metal in each of the plurality of pores sufficient to establish electrical contact from the
nanotube to the conductive material.

US Pat. No. 9,433,943

THERMAL CONTROL OF DROPLETS BY NANOSCALE FIELD EFFECT TRANSISTORS

The Board of Trustees of ...

1. A method of selectively heating a fluid droplet, the method comprising the steps of:
providing a nano-heater transistor having a receiving surface, wherein the nano-heater transistor comprises a field effect
transistor;

introducing a fluid droplet to the receiving surface, the fluid droplet having a droplet volume that is less than 10 nL;
surrounding the fluid droplet exposed surface with a gas phase atmosphere;
heating the nano-heater by applying an AC voltage to the field effect transistor to selectively heat a fluid droplet interior
portion to a fluid droplet maximum temperature without substantially heating the gas phase atmosphere that surrounds the fluid
droplet,

wherein the gas phase atmosphere has a gas phase average temperature and the fluid droplet has an outermost layer having a
thickness selected from a range that is between 1 ?m and 10 ?m with a fluid droplet minimum temperature, and the minimum fluid
droplet temperature is within 10% of the gas phase average temperature and the fluid droplet maximum temperature is more than
100% different than the minimum fluid droplet temperature;

thereby selectively heating the fluid droplet.
US Pat. No. 9,416,282

ANTIFOULING BY ADHESION SUPPRESSION

Purdue Research Foundatio...

1. An antifouling coating comprising:
an antioxidant coating coupled to surfaces submerged in sea water,
wherein the antioxidant is chemically unaltered by the coating,
wherein the antioxidant is present in the coating in an amount sufficient to suppress oxidant-induced marine adhesion and
free radical-induced marine adhesion, and

wherein the antioxidant coating is one of a plurality of coats.

US Pat. No. 9,402,842

SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (TDP1)—TOPOISOMERASE I (TOP1) INHIBITORS

Purdue Research Foundatio...

1. A method for treating a disease or condition responsive to tyrosyl-DNA phosphodiesterase I (Tdp1) inhibition in a host
animal, the method comprising the step of administering to the host animal an effective amount of a compound of the formula
or a pharmaceutically acceptable salt thereof, wherein the compound reduces the activity of Tdp1, when said compound is in
contact with Tdp1; andwherein:
n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, or 12,
RT is amino, methylamino, or dimethylamino, or —(CH2)n—RT represents

in which:
(N) represents the ring nitrogen;
X is a group having the general structure —(CH2)m—[(CH2)x—NRM—(CH2)y]z—(NRN)p—(CH2)q—, where m is 0 or 1, x and y are integers independently ranging from 1 to about 4, z is an integer ranging from 1 to about
4, p is 0 or 1, q is 0 or an integer ranging from 1 to about 2, and where RM and RN are independently selected in each instance from hydrogen and methyl;

Ra and Ra? each independently represent 1-4 substituents each of which is independently selected from the group consisting of hydrogen,
halo, hydroxy, optionally substituted (1-4C)alkyl, optionally substituted (1-4C)alkoxy, cyano, nitro, amino, carboxymethylamino,
optionally substituted alkylthio, optionally substituted alkylsulfonyl, carboxylic acid and derivatives thereof, and sulfonic
acid and derivatives thereof; or Ra and Ra? each represent 2-4 substituents where 2 of said substituents are adjacent substituents and are taken together with the attached
carbons to form an optionally substituted heterocycle, and where any remaining substituents are each independently selected
from the group consisting of hydrogen, halo, hydroxy, optionally substituted (1-4C)alkyl, optionally substituted (1-4C)alkoxy,
cyano, nitro, optionally substituted (1-4C)alkylthio, optionally substituted (1-4C)alkylsulfonyl, carboxylic acid and derivatives
thereof, and sulfonic acid and derivatives thereof; and

Rd and Rd? each independently represent 1-4 substituents each of which is independently selected from the group consisting of hydrogen,
halo, hydroxy, optionally substituted (1-4C)alkyl, optionally substituted (1-4C)alkoxy, cyano, nitro, optionally substituted
(1-4C)alkylthio, optionally substituted (1-4C)alkylsulfonyl, phenyl (which may bear one or more amino, hydroxyl, halo, thiol,
(1-6C)alkyl or halo(1-6C)alkyl substituents), carboxylic acid and derivatives thereof, and sulfonic acid and derivatives thereof;
or Rd and Rd? each independently represent 2-4 substituents where 2 of said substituents are adjacent substituents and are taken together
with the attached carbons to form an optionally substituted heterocycle, and where any remaining substituents are each independently
selected from the group consisting of hydrogen, halo, hydroxy, optionally substituted (1-4C)alkyl, optionally substituted
(1-4C)alkoxy, cyano, nitro, optionally substituted (1-4C)alkylthio, optionally substituted (1-4C)alkylsulfonyl, carboxylic
acid and derivatives thereof, and sulfonic acid and derivatives thereof, and
wherein said disease or condition responsive to tyrosyl-DNA phosphodiesterase I (Tdp1) inhibition is cancer.

US Pat. No. 9,325,052

TUNABLE CAVITY RESONATOR HAVING A POST AND VARIABLE CAPACITIVE COUPLING

Purdue Research Foundatio...

1. A tunable cavity resonator comprising:
a housing defining an interior, the housing having at least one sidewall, a first end, and a second end;
a post within the interior connecting the first end to the second end, the post and the housing defining a resonating cavity;
and

a controllably variable capacitive coupling disposed in the housing.

US Pat. No. 9,250,238

PATHOGEN DETECTION

Purdue Research Foundatio...

1. An article comprising:
a substrate; and
one or more mutation-resistant ligands affixed in a predetermined periodic pattern to at least a portion of the substrate,
wherein the one or more mutation-resistant ligands is affixed to the substrate via a linker, wherein the one or more mutation-resistant
ligands can be bound by pathogens wherein the predetermined periodic pattern is indicative of the pathogen to be selectively
bound to the mutation resistant ligand and is recognizable when a pathogen is bound to the ligand, and

wherein the mutation-resistant ligands are involved in functions important to or essential to virulence of the pathogens.

US Pat. No. 9,192,682

FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES

Endocyte, Inc., West Laf...

1. A process of preparing EC0284:

comprising the reaction of EC0616

and EC0285

in the presence of PyBOP, NHS, and DIPEA.
US Pat. No. 9,056,109

COMPOUNDS AND METHODS FOR TREATING MULTIPLE SCLEROSIS

Purdue Research Foundatio...

1. A method for treating a patient with multiple sclerosis, the method comprising the step of administering to the patient
a therapeutically effective amount of one or more fused hydrazinopyridazines.

US Pat. No. 9,585,376

AUTOMATIC MONITORING OF INSECT POPULATIONS

PURDUE RESEARCH FOUNDATIO...

1. An electronic insect monitoring device (EIMD) comprising:
a lure for attracting at least one target insect species;
one or more bio-impedance sensors configured to generate one or more output signals in response to an insect approaching the
lure, the one or more bio-impedance sensors comprising a high-voltage electric discharge grid; and

an electronic controller configured to determine if the insect approaching the lure belongs to the at least one target insect
species using the one or more output signals.

US Pat. No. 9,517,237

COMPOUNDS AND METHODS FOR TREATING MULTIPLE SCLEROSIS

Purdue Research Foundatio...

1. A composition comprising a fused hydrazinopyridazine in a therapeutically effective amount for treating a patient with
multiple sclerosis, wherein the amount is at least about 2-fold lower than a therapeutically effective amount for treating
hypertension.

US Pat. No. 9,503,681

SIMULATED TRANSPARENT DISPLAY WITH AUGMENTED REALITY FOR REMOTE COLLABORATION

Purdue Research Foundatio...

1. A system comprising:
a first computing device, the first display device comprising:
a first processor;
a first camera coupled to or operable by the first processor, the first camera configured to capture a reference image and
a current image of a view field;

a display configured to display the current image;
a depth acquisition module coupled to or operable by the first processor, the depth acquisition module configured to acquire
geometry information of the view field; and

a first transceiver coupled to or operable by the first processor, the first transceiver configured to:
transmit the reference image and the geometry information; and
receive annotation information to be displayed on the first display; and
a second computing device communicatively connectable with the first computing device, the second computing device comprising:
a second processor;
a user-operable input device coupled or operable by to the second processor;
a second transceiver coupled or operable by to the second processor, the second transceiver configured to receive the reference
image and the geometry information from the first computing device;

an annotation module coupled to or operable by the second processor to receive input via the input device and determine at
least one annotation based at least in part on the input; and

a second display coupled to or operable by the second processor, the second display configured to display the reference image
and to display the at least one annotation superimposed over the reference image,

wherein:
the second transceiver is further configured to transmit reference frame data to the first computing device, the reference
frame data associated, at least in part, with the reference image, the geometry information, and the at least one annotation;
and

the first computing device is further configured to display the at least one annotation anchored to the displayed current
image based on the received reference frame data.

US Pat. No. 9,487,541

FUSED TRICYCLIC ETHER CARBAMATES AND THEIR USE

Purdue Research Foundatio...

1. A compound selected from the group consisting of compounds of the formulas
or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,437,228

NEAR FIELD TRANSDUCER FOR HEAT ASSISTED MAGNETIC RECORDING

PURDUE RESEARCH FOUNDATIO...

1. An antenna for heat assisted magnetic recording, comprising:
an optically opaque material; and
an optically transparent material disposed on the optically opaque material, the optically transparent material including
a half bowtie shape having

a first half-wing substantially shaped in form of trapezoid, having a height substantially equal to the overall height of
the half bowtie;

a second half-wing substantially shaped in form of a mirror image of the first half-wing and formed proximate and coupled
to the first half-wing by a substantially rectangular aperture having a tip width and an aperture gap,

the aperture gap as small as between 1 nm to 5 nm.

US Pat. No. 9,228,154

METHOD OF LOWERING THE CLOUD POINT OF FATTY ACID ESTERS

Purdue Research Foundatio...

1. A method of lowering the cloud point of fatty acid esters, comprising:
(a) providing fatty acid esters;
(b) adding solvent to the fatty acid esters;
(c) adding urea to the fatty acid esters;
(d) mixing the fatty acid esters, solvent and urea;
(e) evaporating the solvent, thereby forming a clathrate-liquid mixture, wherein substantially all of the urea added in step
(c) is used to form clathrates; and

(f) separating the clathrates from the liquid in the mixture formed in step (e), thereby forming refined fatty acid esters
having a lower cloud point than that of the fatty acid esters provided in step (a).

US Pat. No. 9,116,154

ION GENERATION USING WETTED POROUS MATERIAL

Purdue Research Foundatio...

1. A method for analyzing a protein or peptide in a sample, the method comprising:
contacting a sample comprising a protein or peptide to a probe comprising a porous material that tapers to a tip, wherein
the probe operates without pneumatic assistance;

applying a voltage to the porous material such that an electric field is generated at the tip of the material so as to generate
ions of the protein or peptide in the sample that are expelled from the tip; and

analyzing the expelled ions, thereby analyzing the protein or peptide in the sample.

US Pat. No. 9,517,361

CRYSTAL ENCAPSULATED NANOPARTICLES METHODS AND COMPOSITIONS

Purdue Research Foundatio...

1. A method for making a composite of nanometric particles encapsulated by crystals, said method comprising:
crystallizing a solution comprising nanometric particles, a micelle-forming material, a nonpolar dispersant for the micelle-forming
material and a crystal-forming material to form crystal-encapsulated nanometric particles.

US Pat. No. 9,359,317

SMALL MOLECULE INHIBITORS OF HIV PROTEASES

Purdue Research Foundatio...

1. A pharmaceutical composition comprising compound of the formula:

Wherein:
R1 is optionally substituted alkyl or aryl;

R2 is hydrogen or optionally substituted alkyl;

R5 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, or nitrile;

R7 is hydrogen;

R8 is optionally substituted arylalkyl; and

R11 is hydrogen, alkyl, arylalkyl, or a pro-drug moiety; and one or more carriers, diluents or excipients, and combinations thereof.

US Pat. No. 9,246,207

ANTENNA AIMING SYSTEM AND METHOD FOR BROADBAND WIRELESS ACCESS

Purdue Research Foundatio...

1. A method for automatically aiming an antenna to locate a signal transmitted by a remote broadband wireless communication
network device and then initialize and maintain a functional two-way network communication session with the remote broadband
wireless communication network device, the method comprising:
automatically moving the antenna along a path to search for a signal transmitted by the broadband wireless communication network
device before establishing a network communication session between the antenna and the broadband wireless communication network
device;

automatically determining a signal quality value of the signal transmitted by the broadband wireless communication network
device and received by the antenna at a plurality of different locations as the antenna is moved along the path;

automatically storing the determined signal quality values and associated antenna coordinates at the plurality of different
locations as the antenna is moved along the path;

automatically selecting an optimal antenna position based on the stored signal quality values and the associated antenna coordinates;
automatically positioning the antenna at the selected optimal antenna position;
establishing a two-way network communication session between the antenna and the remote broadband wireless communication network
device positioned at the optimal antenna position;

automatically determining whether a trigger event has occurred after the two-way network communication session is established;
automatically moving the antenna along an optimization scan path in an area adjacent the optimal antenna position upon occurrence
of the trigger event while maintaining the two-way network communication session;

automatically determining a signal quality value of a signal transmitted by the broadband wireless communication network device
and received by the antenna at a plurality of different locations along the optimization scan path;

automatically determining whether a new optimal antenna position exists based the signal quality values determined as the
antenna moves along the optimization scan path; and

automatically moving the antenna to the new optimal antenna position upon determining that a new optimal antenna position
exists to optimize the two-way network communication session;

wherein the trigger event occurs when the signal quality value of the signal received by the antenna from the broadband wireless
communication network device decreases below a threshold value; and

wherein a rate of movement along the optimization scan path and a dimension of the optimization scan path adjusted is based
upon at least one of how fast the signal quality value is decreasing and how far the antenna is from the remote broadband
wireless communication network device.

US Pat. No. 9,193,763

PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING

Purdue Research Foundatio...

1. A conjugate selected from the group consisting of

US Pat. No. 9,527,134

METHOD OF PRODUCING TEXTURED SURFACES

Purdue Research Foundatio...

1. A method of machining a body to produce chips and generate a machined surface having a predetermined surface texture, the
method comprising:
performing a simulation in which multiple predicted surface textures are generated for multiple values for modulation amplitudes
and multiple values for modulation frequencies;

selecting the predetermined surface texture for a surface of the body; and then
imposing a superimposed sinusoidal feed-modulation on a cutting tool so as to move the cutting tool in a feed direction relative
to the body while machining the body with the cutting tool to generate the predetermined surface texture in a machined surface
of the body, the superimposed sinusoidal feed-modulation comprising a modulation frequency and a modulation amplitude in the
feed direction;

wherein the predetermined surface texture of the machined surface is intentionally controlled by at least the modulation amplitude
and the modulation frequency of the superimposed sinusoidal feed-modulation;

wherein the step of selecting the predetermined surface texture comprises selecting one of the multiple values for the modulation
amplitudes and one of the multiple values for the modulation frequencies as the modulation frequency and the modulation amplitude
used in the step of imposing the superimposed sinusoidal feed-modulation to generate the predetermined surface texture.

US Pat. No. 9,517,246

CHITOSAN DERIVATIVES FOR INACTIVATION OF ENDOTOXINS AND SURFACE PROTECTION OF NANOPARTICLES

PURDUE RESEARCH FOUNDATIO...

1. An anti-tumor nanoparticle comprising a non-covalent, electrostatic complex between (1) a conjugate comprising a poly(amidoamine)
dendrimer (PAMAM dendrimer) and an anti-tumor agent and (2) a zwitterionic chitosan derivative having an anhydride to amine
(An/Am) ratio of 0.3 to 0.7, wherein (A) the zwitterionic chitosan derivative was synthesized by partial amidation of a chitosan
with succinic anhydride, (B) the weight ratio of zwitterionic chitosan derivative to PAMAM dendrimer is greater than or equal
to 1 but less than or equal to 4, and (C) the size of the anti-tumor nanoparticle is between 250 nm and about 500 nm.

US Pat. No. 9,500,623

SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE

Purdue Research Foundatio...

1. A method for monitoring a reaction in real-time, the method comprising:
selecting a solvent that is compatible as both a reaction solvent and an ionization solvent;
conducting a reaction in the solvent in a vessel;
flowing a portion of the solvent from the vessel to an ion generating device;
generating ions of one or more analytes in the solvent with the ion generating device using the flowed portion of the solvent
from the vessel as the ionization solvent; and

analyzing the ions, thereby monitoring the reaction in real-time.

US Pat. No. 9,359,303

OCTAHYDROBENZOISOQUINOLINE MODULATORS OF DOPAMINE RECEPTORS AND USES THEREFOR

Purdue Research Foundatio...

1. A compound of the formula
or a pharmaceutically acceptable salt thereof, wherein:
RA is 7,8-dihydroxy;

RB is phenyl, optionally substituted with substituents selected from the group consisting of hydroxy, amino, and carboxylic acid;
and

RN is hydrogen; and

wherein the chiral carbons have the following relative stereochemistry

US Pat. No. 9,306,261

MAGNETIC FIELD SYSTEM AND METHOD FOR MITIGATING PASSIVE INTERMODULATION DISTORTION

PURDUE RESEARCH FOUNDATIO...

1. A magnetic field method for mitigating passive intermodulation distortion (PIM), comprising applying an external static
magnetic field to a passive RF component which contains a ferromagnetic material and thereby reducing the intermodulation
distortion produced by the passive RF component, wherein said static magnetic field is sufficiently strong to substantially
saturate the magnetization of the ferromagnetic material in the RF component and reduce magnetic permeability of the passive
RF component, and wherein the RF component is a nickel-containing package lead on an RF circuit board.

US Pat. No. 9,222,158

METHOD OF PRODUCING PARTICULATE-REINFORCED COMPOSITES AND COMPOSITES PRODUCED THEREBY

Purdue Research Foundatio...

1. A particulate-reinforced composite material produced by a process comprising:
forming a melt of a first material;
introducing particles of a second material into the melt and subjecting the melt to high-intensity acoustic vibration, wherein
the particles of the second material have a melting temperature that is higher than the temperature of the melt, wherein a
chemical reaction initiates between the first and second materials that produces reaction products in the melt, the reaction
products comprising a solid particulate phase in the melt, the high-intensity acoustic vibration fragmenting and/or separating
the reaction products into solid particles that are dispersed in the melt and are smaller than the particles of the second
material, wherein the first material is aluminum or an aluminum-based alloy and the second material is titanium or a titanium-based
alloy and the solid particulate phase and the solid particles formed therefrom comprise Al3Ti, wherein the solid particles are spherical or blocky in shape.

US Pat. No. 9,129,786

SYSTEMS AND METHODS FOR ANALYZING A SAMPLE

Purdue Research Foundatio...

1. A sample analysis system, the system comprising:
a discontinuous sample introduction interface;
an ionization mechanism comprising a tube and an electrode; and
a mass analyzer for a miniature mass spectrometer that is located in a vacuum chamber that is separate and distinct from and
operably associated with the ionization mechanism, wherein the ionization mechanism is positioned between the discontinuous
sample introduction interface and the mass analyzer to interact with a sample gas after it has passed through the discontinuous
sample introduction interface and produce ions of the sample gas that are received by the mass analyzer from the separate
and distinct ionization mechanism, and wherein operation of the ionization mechanism is synchronized with opening and closing
of the discontinuous sample introduction interface.

US Pat. No. 9,066,511

CRAWLING ARTHROPOD INTERCEPTING DEVICE AND METHOD

Purdue Research Foundatio...

1. A method of intercepting bed bugs between a leg of a bed, an upholstered sofa, or an upholstered chair and a floor, comprising
placing a bed bug intercepting device on the floor under the leg of the bed, upholstered sofa, or the upholstered chair with
a lower end of the leg received on a bottom wall of an inner most receptacle to provide a path for bed bugs departing from
the bed, upholstered sofa, or upholstered chair to enter the innermost receptacle, wherein the innermost receptacle is formed
by an upstanding peripheral surface that is slippery to prevent bed bugs from climbing out of the innermost receptacle, wherein
the innermost receptacle provides a liquid-free inner pitfall trap of the intercepting device and with an underside of the
bottom wall resting directly on the floor, and surrounding the inner pitfall trap by a second liquid-free outer pitfall trap
formed by multiple upstanding pitfall trap surfaces disposed between the inner pitfall trap and an upstanding, exterior bed
bug-climbable surface of the intercepting device, the second outer pitfall trap comprising an upwardly directed receptacle
open at a top thereof, and using a human on the bed, the upholstered sofa, or the upholstered chair as a bed bug bait in capturing
bed bugs in one of more of the inner or outer pitfall traps as a result of the upstanding peripheral surface and the pitfall
trap surfaces being slippery so that bed bugs cannot climb the upstanding peripheral surface and the pitfall trap surfaces,
including capturing any bed bugs departing from the bed, the upholstered sofa, or the upholstered chair in the inner pitfall
trap and capturing any bed bugs approaching the bed, the upholstered sofa, or the upholstered chair, from the floor in the
outer pitfall trap, whereby an individual can determine whether bed bugs are departing from the bed, upholstered sofa or upholstered
chair, or approaching the bed, upholstered sofa or upholstered chair, or both, by visual inspection of the intercepting device.

US Pat. No. 10,052,722

METHODS OF FORMING HOLES AND ETCHING SURFACES IN SUBSTRATES AND SUBSTRATES FORMED THEREBY

Purdue Research Foundatio...

1. A method comprising:directing a first laser beam pulse towards a substrate to form a hole in a surface thereof having a cross-sectional dimension at a location along a depth of the hole, and to form a plasma plume at least partially within the hole, the plasma plume having insufficient thermal energy and expansion velocity to etch a sidewall of the hole; and
directing a second laser beam pulse into the plasma plume to increase the temperature and expansion velocity of the plasma plume such that the sidewall is etched causing an increase in the cross-sectional dimension at the location in the hole.
US Pat. No. 9,649,354

POLYPEPTIDE INHIBITORS OF HSP27 KINASE AND USES THERFOR

Purdue Research Foundatio...

1. A method for treating a disease, disorder or a condition in a subject in need thereof characterized by inhibiting excretion
of TNF-? from monocytes selected from the group consisting of intimal hyperplasia, Crohn's disease, inflammatory bowel disease,
and psoriasis, the method comprising the step of:
administering a therapeutic amount of a composition comprising an isolated polypeptide and a pharmaceutically acceptable carrier;
wherein the polypeptide comprises a sequence Z1-X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-Z2 (Formula I) (SEQ ID NO: 69);
wherein Z1 and Z2 are independently absent or are transduction domains; and
wherein X1-X2-X3-X4-X5-X6-X7-X8-X9-X10 is an amino acid sequence
selected from the group consisting of the amino acid sequence KALARQLGVAA (SEQ ID NO: 62), the amino acid sequence KALNRQLAVAA
(SEQ ID NO: 66), and the amino acid sequence KALNRQLGVA (SEQ ID NO: 68).

US Pat. No. 9,596,988

PRESSURE SENSORS FOR SMALL-SCALE APPLICATIONS AND RELATED METHODS

Purdue Research Foundatio...

1. A system for monitoring fluid pressure within an eye, the system comprising:
a substrate;
a pressure sensor coupled with the substrate;
an integrated circuit coupled with the substrate and electrically coupled with the pressure sensor;
an antenna coupled with the substrate and electrically coupled with the integrated circuit, the antenna and integrated circuit
adapted to receive a first wireless signal for powering the system and transmit a second wireless signal, the second wireless
signal providing an indication of the fluid pressure; and

an LED coupled with the substrate and electrically coupled with the integrated circuit, wherein a maximum width of the LED
is not greater than the maximum width of the substrate, wherein the light intensity of the LED output provides an indication
of power being received by the system from a wireless external power source.

US Pat. No. 9,498,477

COMPOSITIONS AND USES THEREOF TO AMELIORATE PAIN

Purdue Research Foundatio...

1. A unit dosage form for treating pain, the unit dosage form comprising one or more fused hydrazinopyridazines in a therapeutically
effective amount for treating a patient with a pain disorder, wherein the one or more fused hydrazinopyridazines are the only
active ingredients in a therapeutically effective amount for treatment of pain in the unit dosage, and wherein the at least
one fused hydrazinopyridazine is a compound of the formula

or a pharmaceutically acceptable salt thereof, wherein:
R is independently selected in each instance from hydrogen, acyl, or sulfonyl; or alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl,
heteroalkyl, heteroalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl comprising 3-10 ring members, heteroaryl comprising
3-10 ring members, arylalkyl comprising 3-10 ring members, or heteroarylalkyl comprising 3-10 ring members, each of which
is optionally substituted; and

RA represents three substituents, one of which is selected from the group consisting of hydrogen, halo, hydroxy and derivatives
thereof, amino and derivatives thereof, thio and derivatives thereof, acyl, carboxylate or a derivative thereof, hydroxylamino
and derivatives thereof, hydrazino and derivatives thereof, sulfinyl or a derivative thereof, or sulfonyl or a derivative
thereof; or alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heteroalkyl, heteroalkenyl, cycloheteroalkyl, cycloheteroalkenyl,
aryl comprising 3-10 ring members, heteroaryl comprising 3-10 ring members, arylalkyl comprising 3-10 ring members, or heteroarylalkyl
comprising 3-10 ring members, each of which is optionally substituted; and two of RA are taken together with the attached carbons to form an optionally substituted saturated, unsaturated, or aromatic carbocycle
or heterocycle.

US Pat. No. 9,500,630

ION GENERATION USING MODIFIED WETTED POROUS MATERIALS

Purdue Research Foundatio...

1. A system for analyzing a sample material comprising:
at least one porous substrate connected to a voltage source, wherein the porous substrate is coated with a material that substantially
prevents diffusion of a sample into the substrate in a manner that the sample remains substantially on top of the substrate
until a solvent is applied to the substrate; and

a mass analyzer.

US Pat. No. 9,488,620

WEAK BOND DETECTION

Purdue Research Foundatio...

1. A method, comprising the acts of:
vibrating a structure of bonded layers at a first amplitude by impacting the surface of the structure;
vibrating the structure at a second amplitude different from the first amplitude by impacting the surface of the structure;
evaluating a modal response of the structure to said vibrating at a first amplitude;
evaluating a modal response of the structure to said vibrating at a second amplitude;
correlating the modal responses; and
determining the existence of weak bonding between layers of the structure by identifying a weak correlation between the modal
responses.

US Pat. No. 9,353,072

ANTIMICROBIAL SUBSTITUTED THIAZOLES AND METHODS OF USE

Purdue Research Foundatio...

1. A compound having the structure:

US Pat. No. 9,230,792

ION GENERATION USING MODIFIED WETTED POROUS MATERIALS

PURDUE RESEARCH FOUNDATIO...

1. A system for analyzing a sample material comprising:
at least one porous substrate connected to a high voltage source, wherein at least a portion of the porous substrate comprises
an internal standard and a plurality of pores of the porous substrate are filled with a composition comprising particles of
silica gel that are sized to fit within the pores of the porous substrate; and

a mass analyzer.

US Pat. No. 9,075,140

GNSS EPHEMERIS WITH GRACEFUL DEGRADATION AND MEASUREMENT FUSION

Purdue Research Foundatio...

1. A method for providing an extended propagation ephemeris model for a satellite in Earth orbit comprising:
obtaining within a ground station data associated with a satellite's orbital position over a first period of time;
calculating within the ground station, from the data, coefficients defining osculating Keplarian orbital elements and harmonic
perturbation parameters associated with a coordinate system defining an extended propagation ephemeris model that can be used
to estimate the satellite's position during the first period;

applying a Fourier transform to data derived from the calculated coefficients to determine dominant frequencies of the harmonic
perturbation parameters;

weighting the extended propagation ephemeris model according to a weighing function so that the extended propagation ephemeris
model generates a highest level of accuracy at a beginning of the first period; and

providing the weighted extended propagation ephemeris to a receiver.

US Pat. No. 9,061,057

SYNTHESIS AND COMPOSITION OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR THE TARGETED IMAGING OF TUMORS

Purdue Research Foundatio...

1. A compound having the formula:

or a pharmaceutically acceptable salt thereof,
or isotopes thereof,
wherein:
X is a single amino acid or a single amino acid derivative thereof, wherein the single amino acid or single amino acid derivative
contains an —OH, —NH2, or —SH functional group, and

Y is a dye that has a fluorescence excitation and emission spectra in the near infra red range, wherein Y is represented by
the formula:

wherein, X? is independently selected from the group consisting of O, S, N and C, and R? is independently selected from the
group consisting of CH2 and CH2CH2, and the compound maintains or enhances the fluorescence of the dye, Y.

US Pat. No. 9,850,478

COMPOSITES MATERIAL WITH SUSPENDED PARTICLES AND METHOD OF USING THE SAME

Purdue Research Foundatio...

1. A method of depositing biomolecules or chemical material on a surface, the method comprising:
suspending spores in a hydrogel, generating a hydrogel-spore composite (first composite);
embedding biomolecule or chemical material (agent) into the first composite thereby allowing absorption of the agent by the
spores generating a second composite; and

micro-manipulating the second composite proximate to a surface resulting in deposition of the agent on the surface.

US Pat. No. 9,719,181

SYSTEMS AND METHODS FOR PRODUCING METAL CLUSTERS; FUNCTIONALIZED SURFACES; AND DROPLETS INCLUDING SOLVATED METAL IONS

PURDUE RESEARCH FOUNDATIO...

1. A method for providing droplets comprising metal ions, the method comprising:
contacting a solvent to a metal to produce solvated metal ions;
applying voltage to produce solvent droplets comprising the solvated metal ions; and
directing the solvent droplets comprising the solvated metal ions to a mass spectrometer.

US Pat. No. 9,552,859

ELECTRONIC MEMORY INCLUDING ROM AND RAM

PURDUE RESEARCH FOUNDATIO...

1. A combination random-access memory (RAM) and read-only memory (ROM) electronic data-storage device, comprising:
at least two bit lines;
at least two current sources, each of the current sources connected to a corresponding one of the bit lines;
a plurality of bit cells, the bit cells each comprising a series connection of a selection element and a variably-resistive
storage element, the bit cells each comprising a cell input node having a permanent connection to only one of the bit lines
and a cell output node connected to a source line, the selection element having a control input connected to a word line;

a first sensing amplifier connected to a first one of the bit lines, the first sensing amplifier configured to output a first
voltage when the first bit line is driven above a reference voltage and a second voltage when the first bit line is driven
below the reference voltage;

a second sensing amplifier connected to a second one of the bit lines, the second sensing amplifier configured to output the
first voltage when the second bit line is driven above the reference voltage and the second voltage when the second bit line
is driven below the reference voltage.

US Pat. No. 9,506,084

PRODUCTION OF HYDROGEN USING AN ANAEROBIC BIOLOGICAL PROCESS

Purdue Research Foundatio...

1. A method for producing hydrogen comprising:
providing an organic waste;
fermenting the organic waste in a substantially anaerobic environment, wherein hydrogen is produced from the fermenting;
directing the hydrogen to one of a fuel cell and a heat engine; and
heating the organic waste at a temperature effective to substantially sterilize the organic waste, wherein the heating occurs
subsequent to the fermenting.

US Pat. No. 9,497,928

SYSTEM FOR AUTOMATING ANIMAL TESTING PROTOCOLS

PURDUE RESEARCH FOUNDATIO...

1. A housing system for conducting high throughput animal experiments comprising:
a home cage sized to house a plurality of animals;
at least one rotatable turnstile enclosed by a turnstile housing to form two or more isolation chambers;
one or more action stations functionally linked to one or more of said isolation chambers;
wherein the turnstile comprises one or more separation members rotatable about a vertical axis, each of said isolation chambers
being bounded by at least two of said separation members and a portion of the turnstile housing, each of said isolation chambers
being sized to accommodate only a single animal;

wherein at least one of the one or more action stations comprises a device facilitating completion of an animal-directed or
experimenter-initiated action, and

wherein the turnstile housing comprises a base, walls, and a ceiling, each of the base and ceiling being connectively linked
to the turnstile and the walls, the walls laterally extending around the turnstile to form one or more open regions configured
for connective engagement to the one or more action stations, rotatable turnstiles, or tunnel passageways.

US Pat. No. 9,499,558

COMPOUNDS AND METHODS FOR TREATING HIV

Purdue Research Foundatio...

1. A compound of the formula (I)
or a pharmaceutically acceptable salt thereof, wherein
A is a group of the formula

wherein (*) indicates the point of attachment; in which RQ is amino or alkylamino, which is optionally substituted; or

a group of the formula
wherein (*) indicates the point of attachment; and wherein
m is an integer selected from 0, 1, 2 or 3;
Y1 is oxygen and Y2 is methylene; and Rh amino or alkylamino, which is optionally substituted;

Q and W are each oxygen;
R1 is hydrogen;

X is C(RaRb)n, where n is 1, 2, or 3, and each of Ra and Rb is independently selected in each instance from the group consisting of hydrogen, alkyl, and alkoxy;

R2 is phenyl substituted with one or more methoxy, isopropoxy, hydroxymethyl, methoxymethyl, methoxyethyl, halo or 2-(morpholino)ethoxy
groups;

R3 is hydrogen;

R4 is alkyl, which is optionally substituted;

Z is S(O)2;

R5 is 4-aminophenyl, 4-methoxyphenyl, 4-isopropoxyphenyl, 4-hydroxymethylphenyl; 3-amino-4-methoxyphenyl, 3-amino-4-isopropoxyphenyl,
4-amino-3-fluorophenyl, 3-fluoro-4-methoxyphenyl, 3,4-methylenedioxyphenyl, or a group of the formula:

wherein (*) indicates the point of attachment; in which X5 is O, S or NH; and RY is (1-4C)alkylthio, (1-4C)alkylsulfinyl, (1-4C)alkylsulfonyl or NHRX or NRXRZ and each of RX and RZ is independently methyl, isopropyl, cyclopropyl, isobutyl, tert-butyl, cyclohexyl, 4-piperidinyl 1-cyclopentylpiperidin-4-yl,
or the group NRXRZ is optionally substituted pyrrolidino, piperidino or piperazino.
US Pat. No. 9,500,654

METHODS FOR IDENTIFYING PROTEIN-PROTEIN INTERACTIONS

Purdue Research Foundatio...

1. A method for analyzing two transiently interacting proteins in a sample, wherein a first protein is fused with a first
fragment of a reporter protein and a second protein is fused with a second fragment of said reporter protein, the method comprising:
conducting a protein-fragment complementation assay on the sample to form a protein-protein complex transiently under physiological
conditions;

separating the complex from the sample using a moiety that specifically binds a fused form of the reporter protein but not
either of the first and second proteins individually, and applying a washing condition to the sample that removes the first
and second proteins in their free form while preserving the complex; and

quantitatively analyzing at least one protein of the complex using a mass spectrometry technique.
US Pat. No. 9,493,508

POLYPEPTIDE INHIBITORS OF HSP27 KINASE AND USES THEREFOR

Purdue Research Foundatio...

1. A method for treating a disease, disorder or a condition in a subject in need thereof characterized by inhibiting excretion
of TNF-? from monocytes selected from the group consisting of osteoarthritis, rheumatoid arthritis, gliosis, and scar formation
in the central nervous system, the method comprising the step of:
administering a therapeutic amount of a composition comprising an isolated polypeptide and a pharmaceutically acceptable carrier;
wherein the polypeptide comprises a sequence Z1-X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-Z2 (Formula I) (SEQ ID NO: 69);
wherein Z1 and Z2 are independently absent or are transduction domains; and
wherein X1-X2-X3-X4-X5-X6-X7-X8-X9-X10 is an amino acid sequence selected from the group consisting of the amino acid sequence
KALARQLGVAA (SEQ ID NO: 62), the amino acid sequence KALNRQLAVAA (SEQ ID NO: 66), and the amino acid sequence KALNRQLGVA (SEQ
ID NO: 68).

US Pat. No. 9,391,730

METHOD AND APPARATUS FOR INTERFERENCE ALIGNMENT IN A WIRELESS COMMUNICATION SYSTEM

Samsung Electronics Co., ...

1. An interference alignment method of a base station in a wireless communication system including a first base station managing
a first cell and a second base station managing a second cell, the method comprising:
measuring, at the first base station, a channel of a serving base station and interference channel of neighbor base station
from terminals located in the first and second cells;

generating an interference alignment plane based on a result of the measurement;
calculating a transmission precoder, based on the interference alignment plane, for the terminal located in the second cell,
the transmission precoder preventing the terminal located in the second cell from being influenced by interference a channel
from the first cell to which the interference alignment plane is applied; and

transmitting the transmission precoder to the terminal located in the second cell,
wherein the interference alignment plane is generated by mapping a predetermined column of a null space matrix orthogonal
with the interference channel to a predetermined row of the interference alignment plane.

US Pat. No. 9,363,880

METHOD AND SYSTEM FOR TREATING PACKAGED PRODUCTS

PURDUE RESEARCH FOUNDATIO...

1. A system for processing a product, comprising:
a working gas;
a closed storage volume for containing the product and the working gas; and
a dielectric barrier discharge apparatus (DBD) comprising a first electrode, a second electrode and a dielectric material
disposed therebetween,

wherein the closed storage volume is dimensioned to be insertable between the first electrode and the second electrode of
the DBD; and

wherein the DBD is configured to create an atmospheric non-equilibrium plasma (ANEP) only within the closed storage volume
inserted between the first electrode and the second electrode; the working gas includes a noble gas in a percentage sufficient
to reduce a voltage gradient needed to create the ANEP with respect to an atmospheric pressure air manufacturing environment;
and, the dielectric material is disposed in an atmospheric pressure air manufacturing environment that is accessible by manufacturing
personnel during application of the voltage gradient to the DBD.

US Pat. No. 9,359,277

COMPOSITIONS AND PROCESSES OF PREPARING AND USING THE SAME

Purdue Research Foundatio...

1. A composition comprising a base and a compound of Formula (I)

wherein
R1 is H, halo, or C1-8 alkyl;

R2 is H, halo, or C1-8 alkyl; and

R3 is H, halo, C2-8 alkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, (CO)R6, (CO)OR6, (CO)SR6, (CO)NR6R7, (SO2)R6, (PO)R6R7, or C(NR6)R7, wherein R6 and R7 are independently selected from H, C1-8 alkyl, O—C1-5 alkyl, C3-6 cycloalkyl, aryl-C1-5 alkyl, and heteroaryl-C1-5 alkyl, aryl, substituted aryl, heteroaryl, and substituted heteoaryl

or R2 and R3, together with the carbon atom to which they are attached, form a 4-7 membered cycloalkyl group or cyclo(hetero)alkyl group.

US Pat. No. 9,180,215

POSITRON EMISSION TOMOGRAPHY IMAGING METHOD

Purdue Research Foundatio...

1. A method of diagnosing or monitoring in a patient a folate receptor expressing cancer, the method comprising the steps
of:
a. administering to the patient an effective amount of a composition comprising a compound of the formula
wherein V is a folate receptor binding moiety, or an analog or derivative thereof; L is an optional bivalent linker; n is
an integer selected from 1 to about 100; and Ar is an aryl group that includes one or more independently selected substituents,
Rf, wherein Rf comprises a radiophore or a precursor to a radiophore; and an optional carrier therefor;
b. allowing sufficient time for the compound to bind to the cancer;
c. detecting the compound bound to the cancer with an extra-corporeal PET imaging device; and
d. diagnosing or monitoring the cancer extra-corporally using positron emission tomography.

US Pat. No. 9,183,466

CORRELATING VIDEOS AND SENTENCES

Purdue Research Foundatio...

19. A method of testing a video against an aggregate query, the video including image data of each of a plurality of frames,
the method comprising automatically performing the following steps using a processor:
receiving an aggregate query defining one or more participant(s) and one or more condition(s) with respect to the participant(s);
detecting one or more candidate object(s) in each of the plurality of frames of the video;
providing a unified cost function using the detected candidate object(s) for computing how closely an input combination of
the candidate object(s) corresponds to one or more object track(s) and how closely the corresponding one or more object track(s)
correspond to the participant(s) and the condition(s);

determining whether the video corresponds to the aggregate query by mathematically optimizing the unified cost function to
select a combination of the detected candidate object(s) that has an aggregate cost with respect to the participant(s) and
the condition(s).

US Pat. No. 9,175,937

GASLESS IGNITION SYSTEM AND METHOD FOR MAKING SAME

Purdue Research Foundatio...

1. A method for making a gasless ignition system for igniting a material charge, comprising the steps of:
providing a housing having a first end and an opposing second end and defining an elongate channel extending between the first
and second ends;

mechanically activating a reactive material comprising at least first and second elements;
packing said housing with the mechanically activated reactive material;
positioning an initiator element at the first end of the housing and in contact with the mechanically activated reactive material;
and

positioning the second end of the housing adjacent a combustible material,
wherein, upon actuation of the initiator element, the mechanically activated reactive material burns from its point of ignition
at the first end of the housing to the opposite second end of the housing to ignite the combustible material,

wherein the gasless ignition system provides a delay measured as the time it takes for the mechanically activated reactive
material to burn from its point of ignition at the first end of the housing to the opposite second end of the housing and
the mechanically activated reactive material in said housing has an ignition input energy level, and

wherein at least one of the duration of the delay and the ignition input energy level is selectively determined by varying
at least one of the intensity and duration of the mechanical activation.

US Pat. No. 9,173,994

TOUCH-ACTUATED MICROPUMP FOR TRANSDERMAL DRUG DELIVERY AND METHOD OF USE

PURDUE RESEARCH FOUNDATIO...

1. A micropump device, comprising:
a first layer forming a first chamber storing a working material;
a second chamber defined by a deflectable membrane separating the second chamber from the first chamber and configured to
deflect in response to a volume increase in the first chamber, the second chamber storing a drug compound to be delivered
to a subject's vascular system; and

at least one needle in fluid communication with the second chamber and configured to penetrate a subject's skin to pump the
drug compound in response to deflection of the deflectable membrane;

wherein the working material in the first chamber is a phase-change material that increases in volume in response to application
of heat from a user's skin to the first layer,

the deflectable membrane in fluid contact with the phase-change material in the first chamber and in fluid contact with the
drug compound in the second chamber.

US Pat. No. 9,165,754

DIFFERENTIALLY PUMPED DUAL LINEAR QUADRUPOLE ION TRAP MASS SPECTROMETER

Purdue Research Foundatio...

1. A mass spectrometry system comprising:
a first linear quadrupole ion trap mass spectrometer in a first vacuum chamber;
a second linear quadrupole ion trap mass spectrometer in a second vacuum chamber, the second linear quadrupole ion trap mass
spectrometer configured to analyze the mass-to-charge ratio of a charged particle provided from the first linear quadrupole
ion trap mass spectrometer; and

a vacuum manifold operably coupled between the first and second vacuum chambers and configured to allow the charged particle
to travel from the first linear quadrupole ion trap mass spectrometer in the first vacuum chamber to the second linear quadrupole
ion trap mass spectrometer in the second vacuum chamber.

US Pat. No. 9,165,097

PROGRAMMABLE MICROFLUIDIC SYSTEMS AND RELATED METHODS

PURDUE RESEARCH FOUNDATIO...

1. A method to facilitate translating from a programming language to a set of execution requests for a programmable microfluidic
chip, comprising the steps of:
reading a description file that includes information regarding hardware components of the programmable microfluidic chip including
a number of reservoirs, a number of fluidic functional units, and a number of channels connected to a set of external hardware
instrumentation;

receiving a program file comprising a sequence of instructions;
generating a sequence of execution requests by translation based on the description file and the program file;
interfacing between the set of execution requests and the hardware components of the programmable microfluidic chip by mapping
each execution request of the sequence to a single state of hardware components;

executing the sequence of execution requests;
triggering the hardware components of the programmable microfluidic chip according to said executing step; and
activating the external hardware instrumentation.

US Pat. No. 10,072,969

NONLINEAR MASS SENSORS BASED ON ELECTRONIC FEEDBACK AND METHODS OF USING THE SAME

Purdue Research Foundatio...

1. A method for mass sensing, wherein the mass sensing comprises: obtaining a first linear signal generated through contacting a material to be sensed with a functional surface layer of a mass sensor; applying one or more non-linear electrical operations through a non-linearity feedback subsystem to said first linear signal to generate a second non-linear signal, wherein said one or more non-linear electrical operations are capable of generating bifurcation in said second non-linear signal when said one or more non-linear electrical operations are applied to the first linear signal; and wherein the second non-linear signal is summed to an excitation signal to excite the mass sensor.
US Pat. No. 9,771,345

COFERONS AND METHODS OF MAKING AND USING THEM

Cornell University, Itha...

1. A therapeutic dimer comprising:
covalently or non-covalently linked monomers, each monomer comprising either a boronic acid linker element or a binding partner
linker element,

wherein the monomer comprising the boronic acid linker element is selected from the group consisting of:
[2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1H-indol-4-yl]boronic acid; (2-{[5-(aminomethyl)-2H-spiro[1-benzofuran-3,4?-piperidine]-1?-yl]carbonyl}-1H-indol-4-yl)boronic
acid; (5-{[5-(aminomethyl)-2H-spiro[1-benzofuran-3,4?-piperidine]-1?-yl]carbonyl}naphthalen-2-yl)boronic acid; [5-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic
acid; [2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1H-indol-5-yl]boronic acid; [5-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1H-indol-2-yl]boronic
acid; [2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1H-indol-6-yl]boronic acid; [8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic
acid; (2-{[5-(aminomethyl)-2H-spiro[1-benzofuran-3,4?-piperidine]-1?-yl]carbonyl}-1H-indol-6-yl)boronic acid; (2-{[5-(aminomethyl)-2H-spiro[1-benzofuran-3,4?-piperidine]-1?-yl]carbonyl}-1H-indol-5-yl)boronic
acid; (2-{[5-(aminomethyl)-2H-spiro[1-benzofuran-3,4?-piperidine]-1?-yl]carbonyl}-1H-indol-5-yl)boronic acid; (5-{[5-(aminomethyl)-2H-spiro[1-benzofuran-3,4?-piperidine]-1?-yl]carbonyl}-1H-indol-3-yl)boronic
acid; [4-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1-benzofuran-2-yl]boronic acid; (3-{[5-(aminomethyl)-2H-spiro[1-benzofuran-3,4?-piperidine]-1?-yl]carbonyl}-1H-indol-6-yl)boronic
acid; and

wherein the monomer comprising the binding partner linker element is selected from the group consisting of:
4-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)-2-hydroxybenzamide; 4-[(1E)-3-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-3-oxoprop-1-en-1-yl]-2-hydroxybenzamide;
5-[(1E)-3-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-3-oxoprop-1-en-1-yl]-2-hydroxybenzamide; 8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1,3-dihydroxynaphthalene-2-carboxamide;
3-[(1E)-3-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-3-oxoprop-1-en-1-yl]-2,6-dihydroxybenzamide; (2R)-2-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-2-hydroxy-2-phenylacetic
acid; (2R)-2-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-2-cyclopentyl-2-hydroxyacetic acid; (2R)-2-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-2-cyclopropyl-2-hydroxyacetic
acid; 4-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-7,8-dihydroxy-2H-chromen-2-one; 3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-6,7-dihydroxy-2H-chromen-2-one;
4-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)-6,7-dihydroxy-2H-chromen-2-one; 3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-7,8-dihydroxy-2H-chromen-2-one;
3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)-6,7-dihydroxy-4-methyl-2H-chromen-2-one; 3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)-7,8-dihydroxy-4-methyl-2H-chromen-2-one;
4-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)-7, 8-dihydroxy-2H-chromen-2-one; (1S,2S,3R,5S)-2-{2-[4-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]ethyl}-6,6-dimethylbicyclo[3.1.1]heptane-2,3-diol;
(1R,2R,4S,5R,6S)—N-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-5,6-dihydroxybicyclo[2.2.2]octane-2-carboxamide;
(1R,2R,3R,4R,5S)-4-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-2,6,6-trimethylbicyclo[3.1.1]heptane-2,3-diol;
(1R,2R,4S,5S,6R)—N-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-5,6-dihydroxybicyclo[2.2.2]octane-2-carboxamide;
(1S,2R,3R,4R,5R)-4-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-2,6,6-trimethylbicyclo[3.1.1]heptane-2,3-diol;
(1R,2R,4S,5R,6S)—N-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-5,6-dihydroxybicyclo[2.2.1]heptane-2-carboxamide;
(1S,2R,3S,4S,5R)-5-[4-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-5-methylbicyclo[2.2.1]heptane-2,3-diol;
(1S,2R,4R,5S,6R)—N-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-5,6-dihydroxybicyclo[2.2.2]octane-2-carboxamide;
(1R,2R,3S,4R,5S)-5-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]bicyclo[2.2.2]octane-2,3-diol; (1R,2S,3R,4R,5S)-5-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-5-methylbicyclo[2.2.1]heptane-2,3-diol;
(2R)-3-{[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]carbamoyl}-2-hydroxy-2-phenylpropanoic acid; (2S)-3-{[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]carbamoyl}-2-hydroxy-2-phenylpropanoic
acid; (2R)-2-[4-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-]H-indol-2-yl]-2-hydroxypropanoic acid; (2S)-3-{[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]carbamoyl}-2-hydroxy-2-methylpropanoic
acid; (2S)-3-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-2-hydroxy-2-phenylpropanoic acid; (2R)-3-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-2-hydroxy-2-phenylpropanoic
acid; (2S)-3-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-2-hydroxy-2-methylpropanoic acid; (2R)-3-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-2-hydroxy-2-methylpropanoic
acid; (2S)-2-[2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1H-indol-4-yl]-2-hydroxypropanoic acid; (2R)-2-[2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-]H-indol-4-yl]-2-hydroxy-2-phenylacetic
acid; (2R)-2-[2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1H-indol-4-yl]-2-hydroxypropanoic acid; (2R)-2-[2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1H-indol-6-yl]-2-hydroxypropanoic
acid; 2-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-1-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]ethan-1-one;
(2R)-3-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]propane-1,2-diol; 2-[(1E)-3-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-3-oxoprop-1-en-1-yl]-6-hydroxybenzamide;
8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-3-hydroxynaphthalene-2-carboxamide; (1R,2S,3R,4R,5S)-5-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]bicyclo[2.2.2]octane-2,3-diol;
(1R,2S,4S,5S,6R)—N-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-5,6-dihydroxybicyclo[2.2.2]octane-2-carboxamide;
(2S)-3-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenoxy]-2-cyclopentyl-2-hydroxypropanoic acid; (2S)-3-{[4-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]carbamoyl}-2-hydroxy-2-phenylpropanoic
acid; (2R)-2-[2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-]H-indol-6-yl]-2-hydroxy-2-phenylacetic acid; (2R)—S-[3-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)phenyl]-3,3,3-trifluoro-2-hydroxypropane-1-sulfonamido;
1-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-(3,4-dihydroxyphenyl)ethan-1-one; (2R)-2-[3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]-2-hydroxy-2-phenylacetic
acid; (2S)-2-[5-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]-2-hydroxypropanoic acid; (2S)-2-[2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-]H-indol-6-yl]-2-hydroxypropanoic
acid; (2S)-2-[2-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)-1H-indol-6-yl]-2-hydroxy-2-phenylacetic acid; (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone;
(E)-1-(4-(3-(aminomethyl)phenyl)piperidin-1-yl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one; (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6,7-dihydroxynaphthalen-1-yl)methanone;
and 4-(aminomethyl)-N-(4-(2-((3R,4S)-3,4-dihydroxypyrrolidin-1-yl)-2-oxoethoxy)benzyl)benzamide.

US Pat. No. 9,518,114

TREATING BLADDER TUMOR CELLS USING FIBRONECTIN ATTACHMENT PROTEIN AS A TARGET

Purdue Research Foundatio...

1. A method of enhancing targeted uptake of therapeutic or diagnostic agents by a patient's cells, said method comprising
the steps of:
providing a multivalent complex comprising at least one carrier and a plurality of fibronectin attachment proteins or functional
equivalents thereof attached to the carrier such that each fibronectin attachment protein or functional equivalent thereof
is positioned within submicrons of at least one other fibronectin attachment protein or functional equivalent to form a cluster
and wherein said complex is linked to a therapeutic or diagnostic agent; and

administering said complex to said patient;
wherein upon contact between receptors of a patient cell and the fibronectin attachment proteins or functional equivalents
thereof of the complex, the cluster further comprises the receptors of the patient cell.

US Pat. No. 9,499,444

ALKYL ESTER POLYSTYRENE BLENDS FOR USE IN CONCRETE

Purdue Research Foundatio...

1. A method of treating a porous material, comprising:
providing fatty acid alkyl esters having 16 to 22 carbon atoms;
dissolving polystyrene in the fatty acid alkyl esters to form a blend composition; and
applying the blend composition to a cementitious material.
US Pat. No. 9,488,582

METHODS FOR MEASURING CONCENTRATIONS OF CHLORINATED SOLVENTS THROUGH RAMAN SPECTROSCOPIC OBSERVATION OF THE VIBRATIONAL MODES OF WATER

PURDUE RESEARCH FOUNDATIO...

1. A method comprising:
providing a plurality of non-turbid aqueous chlorinated solvent calibration solutions, the calibration solutions comprising
solutions of water and a chlorinated solvent, each calibration solution having a concentration of the chlorinated solvent
within a predetermined concentration range, at least two of the chlorinated solvent calibration solutions having different
concentrations of the chlorinated solvent within the predetermined concentration range;

measuring intensity of Raman return at a predetermined Raman shift associated with O—H stretching region of water for each
of the plurality of non-turbid aqueous chlorinated solvent calibration solutions;

developing a calibration profile for non-turbid solutions relating chlorinated solvent concentrations of the plurality of
the non-turbid aqueous chlorinated solvent calibration solutions to the measured intensities;

obtaining a non-turbid aqueous solution sample whose chlorinated solvent concentration has to be determined, the sample containing
the chlorinated solvent;

measuring intensity of Raman return at the predetermined Raman shift associated with O—H stretching region of the non-turbid
aqueous solution sample;

comparing the intensity of Raman return at the predetermined Raman shift associated with O—H stretching region of the non-turbid
aqueous solution sample to the calibration profile for non-turbid solutions; and

determining the concentration of the chlorinated solvent in the non-turbid aqueous solution sample.

US Pat. No. 9,383,267

WIRELESS SENSOR FOR ROTATING ELEMENTS

Purdue Research Foundatio...

1. A system for measuring a physical characteristic of a bearing, comprising:
a permanent magnetic coupled directly to at least a portion of a bearing, the permanent magnet having a magnetic field that
changes as a function of the physical characteristic; and

a magnetic sensor operably disposed in a magnetic field sensing relationship with the permanent magnet, the magnetic sensor
configured to generate a voltage or current signal corresponding to a sensed magnetic field.

US Pat. No. 9,379,313

NON-VOLATILE SPIN SWITCH

PURDUE RESEARCH FOUNDATIO...

1. A circuit element, comprising:
a first nanomagnet inductively coupled to a first current carrying element, the first nanomagnet configured to change polarity
responsive to current in the first current carrying element;

a second nanomagnet magnetically coupled to the first nanomagnet and inductively coupled to a second current carrying element;
a first fixed magnet disposed on the second nanomagnet and having a first fixed polarity; and
a second fixed magnet disposed on the second nanomagnet and having a second fixed polarity.

US Pat. No. 9,343,088

NEAR FIELD TRANSDUCER FOR HEAT-ASSISTED MAGNETIC RECORDING

PURDUE RESEARCH FOUNDATIO...

8. A method of heat-assisted magnetic recording, using a localized surface plasmon resonance (LSPR) for data storage, comprising:
sending a beam of light through a waveguide into a near-field transducer (NFT), wherein said NFT contains a nanostructure
endpoint made of a ceramic material, the ceramic material containing essentially only plasmonic refractory transition metal
nitride and a layer of protective dielectric material over said ceramic plasmonic material, wherein a first portion of a total
surface area of the NFT is only in contact with the waveguide and a second portion of the total surface area of the NFT which
accounts for an entire surface area of the NFT when combined with said first portion is only in contact with the layer of
protective dielectric material, wherein the layer of protective dielectric material is not part of the waveguide and said
second portion of the total surface area of the NFT is both substantially perpendicular and substantially parallel to an air-bearing
surface (ABS), creating a surface plasmon-enabled local heating in said nanostructure endpoint; and said heated endpoint of
said NFT interfacing through the ABS to a recording disk, thus enabling magnetic recording.

US Pat. No. 9,804,159

IMMUNOREACTIVE ANTIGENS OF MYCOPLASMA HAEMOFELIS AND DIAGNOSTIC IMMUNOASSAY

Purdue Research Foundatio...

1. A peptide complex comprising one or more different recombinant fusion peptides and a solid support, wherein the one or
more recombinant fusion peptides each comprises
an amino acid sequence selected from the group consisting of SEQ ID NO: 1 through SEQ ID NO: 60 and a terminal amino acid
sequence covalently linked at the carboxy or amino terminus of the one or more recombinant fusion peptides;

wherein the one or more recombinant fusion peptides does not encode a native amino acid sequence of Mycoplasma haemofelis; and

wherein the one or more recombinant fusion peptides are immobilized on the solid support.

US Pat. No. 9,504,936

METHOD OF PACKING CHROMATOGRAPHIC COLUMNS

Purdue Research Foundatio...

1. A method for packing a chromatographic column comprising silica particles, the method comprising the steps of
a) introducing the silica particles into the chromatographic column, wherein the chromatographic column has a length of 2
to 10 cm and an inner diameter of 25 ?m to 5 cm, and the silica particles have a diameter of 100 nm to 900 nm;

b) ultrasonicating the chromatographic column; and
c) applying pressure to the silica particles,
wherein steps a)-c) are performed simultaneously and wherein a packed chromatographic column with an eddy diffusion term of
less than 1 ?M is formed, wherein the silica particles are uniformly packed and exhibit no cracks or uninterrupted contact
between the inner surface of the column and the silica particles, and wherein the packed chromatographic column is suitable
for HPLC, UHPLC, or FPLC.

US Pat. No. 9,474,909

WIRELESS MAGNETIC TRACKING

PURDUE RESEARCH FOUNDATIO...

1. A wireless magnetic tracking system comprising: a plurality of transmitting coils each configured to generate a magnetic
field when energized;
an active transponder configured to simultaneously (i) obtain measurements of the magnetic field when one of the plurality
of transmitting coils is energized and (ii) transmit a wireless signal containing data concerning the measurements;

a computing device configured to (i) cause each of the plurality of transmitting coils to be sequentially energized, (ii)
receive the data concerning the measurements, and (iii) determine a position and an orientation of the active transponder
relative to the plurality of transmitting coils in response to the data concerning the measurements;

a coil driver circuit configured to selectively supply an excitation signal to each of the plurality of transmitting coils,
wherein the computing device is configured to control the coil driver circuit; and

a receiver configured to (i) receive the wireless signal from the active transponder and (ii) provide the data concerning
the measurements to the computing device;

wherein the receiver comprises a plurality of antennas configured to simultaneously receive the wireless signal from the active
transponder and a combiner configured to sum the wireless signals received by the plurality of antennas.

US Pat. No. 9,408,930

GENERATION OF MICROBIOCIDE INSIDE A PACKAGE UTILIZING A CONTROLLED GAS COMPOSITION

PURDUE RESEARCH FOUNDATIO...

1. A method of treating an object, comprising:
providing a dielectric barrier discharge (DBD) device;
providing a container suitable for substantially completely enclosing the object;
inserting the object into the container;
filling the container with a working gas at substantially atmospheric pressure;
disposing a portion of the container with respect to the DBD device such that reactive species are produced in the container
by the DBD apparatus; and,

activating the DBD device for a first period of time by applying a voltage gradient,
wherein the voltage gradient applied to the DBD device is greater than approximately 1.4 times an ionization voltage gradient
of the working gas and the method is performed with a surface of the container at substantially atmospheric pressure.

US Pat. No. 9,364,584

DEMINERALIZED CANCELLOUS BONE SCAFFOLDS

Purdue Research Foundatio...

1. A cancellous bone scaffold configured for insertion into a calcified bone matrix to repair a soft connective tissue interface
with a bone, the cancellous bone scaffold comprising a contiguous scaffold having a mineralized cancellous bone segment and
a demineralized cancellous bone segment and at least one partially demineralized interface between the mineralized segment
and the demineralized segment, the partially demineralized interface comprising 2% to 10% calcium, wherein both the mineralized
segment and the demineralized segment are crosslinked, wherein the cancellous bone scaffold has been treated to remove osteoinductivity
from at least the demineralized segment, and wherein the cancellous bone scaffold is capable of forming a direct or indirect
insertion into a calcified bone matrix.

US Pat. No. 9,357,928

VIBRATIONAL PHOTOACOUSTIC TOMOGRAPHY USING RAMAN LASER

Purdue Research Foundatio...

1. A method of noninvasively imaging tissue within a body, the method comprising:
irradiating the tissue with radiation from an imaging laser including a Raman-based laser tuner, radiation including a plurality
of laser pulses from the imaging laser to the tissue, each pulse having energy greater than 100 mJ;

receiving an acoustic signal generated by vibrational energy in the tissue,
wherein the vibrational energy is a result of selective overtone excitation of molecules in the tissue by radiation; and
automatically converting the acoustic signal to an image representative of the tissue using a processor;
the irradiating step includes providing energy to a cavity of the imaging laser using Nd:YAG laser,
and the Nd:YAG laser has an output wavelength between 1044 nm 1084 nm, the imaging laser has an output wavelength between
1177 nm and 1217 nm, and the tissue includes atoms having C—B bonds, so that radiation from the imaging laser excites a second
overtone vibration band of the C—H bonds.

US Pat. No. 9,354,125

HIGHLY-RELIABLE MICRO-ELECTROMECHANICAL SYSTEM TEMPERATURE SENSOR

Purdue Research Foundatio...

1. A sensor arrangement for wirelessly measuring temperature and vibration, comprising:
a sensor element affixed on a device;
a sensor coil affixed on the device, coupled to the sensor element;
a readout coil configured to be magnetically coupled to the sensor coil at a first distance, having a coupling factor dependent
on the first distance, configured to:

energize the sensor coil with an energizing signal,
provide a natural frequency of the sensor element, the sensor coil, and the readout coil, and
provide amplitude modulations of the energizing signal, the amplitude modulations being induced by changes in the coupling
factor of the readout coil and the sensor coil;

an energizing circuit coupled with the readout coil and configured to energize the readout coil with the energizing signal;
and

a readout circuit coupled to the readout coil and configured to store or display information regarding the natural frequency
and the amplitude modulations.

US Pat. No. 9,327,008

CELL-PERMEANT PEPTIDE-BASED INHIBITOR OF KINASES

Purdue Research Foundatio...

1. A method for treating an inflammatory disorder characterized by IL-6 expression induced by IL-1?, TNF-?, or a combination
thereof, the method comprising the step of:
administering a kinase inhibiting composition to a subject in need thereof, wherein the kinase inhibiting composition comprises
(a) a therapeutic amount of a therapeutic MK2 kinase inhibitor peptide comprising a protein transduction domain and a therapeutic
domain, wherein the therapeutic domain has amino acid sequence KALARQLGVAA [SEQ ID NO: 23]; and

(b) a pharmaceutically acceptable carrier,
wherein the therapeutic amount of the composition is effective
(a) to inhibit an MK2 kinase; and
(b) to reduce expression of IL-6 induced by IL-1?, TNF-?, or a combination thereof, and thereby treat the inflammatory disorder.

US Pat. No. 9,319,251

MULTIPLE-INPUT MULTIPLE-OUTPUT (MIMO) COMMUNICATION SYSTEM USING A CODEBOOK AND METHOD OF DESIGNING THE CODEBOOK

Samsung Electronics Co., ...

1. A communication method of a receiver, the communication method comprising:
calculating an eigenvector matrix comprising eigenvectors of a channel matrix or a channel covariance matrix;
generating a codebook for each eigenvector of the eigenvector matrix such that each codebook has a different size based on
eigenvalues of the channel matrix or the channel covariance matrix;

quantizing each of the eigenvectors using the respective codebook for each eigenvector; and
transmitting, to a transmitter, information associated with each of the quantized eigenvectors;
wherein the generating comprises generating a largest size codebook for a codebook corresponding to a dominant eigenvector
from among the eigenvectors,

wherein the quantizing comprises:
quantizing an ith eigenvector using the codebook corresponding to the ith eigenvector;
projecting the codebook corresponding to an (i+1)th eigenvector onto a null space of the quantized ith eigenvector; and
quantizing the (i+1)th eigenvector using the projected codebook corresponding to the (i+1)th eigenvector.

US Pat. No. 9,175,002

SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (TDP1)—TOPOISOMERASE I (TOP1) INHIBITORS

Purdue Research Foundatio...

1. A compound of the formula
or a pharmaceutically acceptable salt thereof,wherein:
RT is amino, Ra is 3-carboxymethylamino and Rd is hydrogen; or

RT is amino, Ra is 3-amino and Rd is 9-methoxy; or

RT is amino, Ra is 3-iodo and Rd is hydrogen; or

RT is dimethylamino, Ra is 3-iodo and Rd is 9-methoxy; or

RT is dimethylamino, Ra is 3-cyano and Rd is hydrogen.

US Pat. No. 9,169,128

SYNTHESIS OF METAL OXIDE-BASED THERMOELECTRIC MATERIALS FOR HIGH TEMPERATURE APPLICATIONS

PURDUE RESEARCH FOUNDATIO...

1. A process for forming nanowires, the process comprising:
combining cobalt oxide nanowires with a solution comprising KOH mixed with calcium nitrate or sodium nitrate to create a combination;
and,

processing the combination by heating the combination at a temperature above 200° C. for at least one day to form an end product.

US Pat. No. 9,159,540

SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS

Purdue Research Foundatio...

1. A system for analyzing a sample, the system comprising:
an ionizing source for converting molecules of a sample into sample ions;
an ion analysis device;
a pump external to the ion analysis device; and
an ion transfer member, wherein the pump facilitates collection of the sample ions in the ion transfer member, which sample
ions are transferred through the ion transfer member to an inlet of the ion analysis device, wherein the ion transfer member
is a tube that has a diameter greater than a diameter of the inlet of the ion analysis device.

US Pat. No. 9,086,499

CLUSTERING PROTOCOL FOR DIRECTIONAL SENSOR NETWORKS

Purdue Research Foundatio...

1. A method of tracking target objects in a network of unidirectional sensors which correspond to nodes on the network, the
method comprising
identifying the presence of a target object by a first unidirectional sensor,
determining a first value for the relationship of the target object to the first unidirectional sensor,
sending a message to at least one second unidirectional sensor which is a neighbor to the first unidirectional sensor, the
message including a unique identification of the target object and the first value,

monitoring messages from at least one second unidirectional sensor sending a second value indicative of the relationship of
the target object to the at least one second unidirectional sensor,

ranking the first value and second value, if available, and the first unidirectional sensor utilizing the ranking of the first
and second criterion to determine

whether to elect itself the head of a cluster including at least the first unidirectional sensor or join a cluster headed
by a second unidirectional sensor, and

propagating the cluster by dropping a sensor from the cluster when the target object gets out of the sight of the sensor.
US Pat. No. 9,867,905

COLLAGEN-BASED MATRICES WITH STEM CELLS

PURDUE RESEARCH FOUNDATIO...

1. A tissue graft composition, said composition comprising:
an engineered, purified collagen-based matrix comprising collagen fibrils, wherein the matrix has a collagen fibril microstructure
including fibril-fibril branching; and

a network of lumenized, endothelial cell-lined vessels formed in vitro, said vessels capable of persisting for more than 7
days in vitro;

wherein said collagen fibrils are polymerized from a pig skin collagen source comprising a mixture of type I collagen monomers
and oligomers, wherein the concentration of collagen in the polymerization reaction is 0.3 mg/ml to 1 mg/ml, wherein the vessels
are formed from endothelial progenitor cells, and wherein the matrix has a shear storage modulus of 40 Pa to 50 Pa and a fibril
volume fraction of 5% to 10%; and

wherein the tissue graft composition is produced by engineering the purified collagen-based matrix, and seeding the matrix
at a density of 1×105 to 5×105 endothelial progenitor cells per milliliter to form one or more vessels within the matrix.

US Pat. No. 9,839,724

SYSTEM AND STENT FOR REPAIRING ENDOVASCULAR DEFECTS AND METHODS OF USE

Purdue Research Foundatio...

1. A coating for improving cellular adhesion, differentiation, and proliferation for use with stents, the coating comprising:
a layer of a magnetic material deposited on a portion of an outer surface of the stent, wherein the magnetic material comprises
a bacterial nanocellulose polymer impregnated with a magnetic metal material; and

an ion-beam nanostructured biocompatible layer deposited on the layer of magnetic material.

US Pat. No. 9,737,244

SENSOR HAVING FERROGEL WITH MAGNETIC PARTICLES

Purdue Research Foundatio...

1. A sensor for detecting a condition, the sensor comprising:
a container;
a hydrogel arranged within the container and configured to change thickness or volume in response to the condition;
a plurality of magnetic particles arranged in the hydrogel so that a magnetic property of the hydrogel changes with changes
of thickness or volume of the hydrogel; and

a device coil arranged within the container and arranged with respect to the hydrogel so that changes in the magnetic property
modulate an electrical property of the sensor, wherein terminals of the device coil are open.

US Pat. No. 9,549,992

FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES

Purdue Research Foundatio...

1. A conjugate of formula ALDm, wherein
A is an antifolate of the formula:

wherein
(1) X?OH, R?H, and Y=Glu; or
(2) X?OCH3, R?H, and Y=Glu; or

(3) X?OH, R?H, and Y=Valine; or
(4) X?OH, R?H, and Y=Suberate; or
(5) X?OH, R?CH3, and Y=Glu;

m is 1 to 3;
D is an independently selected drug; and
L is a linker comprising at least one releasable linker.
US Pat. No. 9,526,802

NUCLEIC ACID COMPLEXES

Purdue Research Foundatio...

1. A nucleic acid complex comprising a nucleic acid, a macrocyclic compound, and a pendant polymer, wherein the pendant polymer
comprises a polymer backbone and is modified with a hydrophobic group, wherein the macrocyclic compound and the pendant polymer
form a host:guest polymer complex, and wherein the nucleic acid is siRNA, mRNA, tRNA, rRNA, cDNA, miRNA, ribozymes, antisense
oligonucleotides, decoy oligonucleotides, plasmid DNA (pDNA), peptide nucleic acids, triplex-forming oligonucleotides (TFOs),
aptamers, or genes, or a derivative or analog thereof, or a combination thereof.
US Pat. No. 9,512,192

COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS, PREPARATION, AND METHODS OF USE

Purdue Research Foundatio...

1. A synthetic peptidoglycan comprising a glycan and from 1 to 50 collagen binding peptides, each of which is covalently bonded
to the glycan, wherein the peptides comprise amino acids 1-18 (RRANAALKAGELYKSILY) of SEQ ID NO: 1.

US Pat. No. 9,484,195

SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS

Purdue Research Foundatio...

1. A system for analyzing a sample, the system comprising:
an ionizing source for converting molecules of a sample into sample ions;
an ion analysis device;
a pump external to the ion analysis device;
an ion transfer member external the ion analysis device, wherein the pump facilitates collection of the sample ions in the
ion transfer member that is external the ion analysis device, which sample ions are transferred through the ion transfer member
to an inlet of the ion analysis device.

US Pat. No. 9,381,110

METHOD AND SYSTEM FOR TRAINING VOICE PATTERNS

PURDUE RESEARCH FOUNDATIO...

1. A voice enhancement device comprising:
an earpiece configured to be positioned in or near an ear of a user;
a microcontroller operatively coupled to the earpiece;
an accelerometer operatively coupled to the microcontroller, wherein the accelerometer is configured to detect speech by the
user and provide an output signal to the microcontroller,

wherein the microcontroller has at least a first state in which multitalker babble is retrieved and provided to the earpiece
in response to the received output signal from the accelerometer when the received output signal is above a reference level
configured to indicate detected speech by the user, wherein the multitalker babble is retrieved and provided to the earpiece
at all levels of detected speech by the user, and a second state without the retrieval and provision of the multitalker babble
when the received output signal is below the reference level indicating an absence of detected speech by the user.

US Pat. No. 9,354,237

METHODS FOR ISOLATING PROTEINS

Purdue Research Foundatio...

1. A method for isolating a plurality of proteins, the method comprising:
preparing a plurality of sample preparations, each preparation comprising one or more intact cells;
introducing a capture unit to a plurality of the preparations, the capture unit comprising a member that transiently interacts
with one or more proteins in the cells and a reactive functional group;

incubating the sample preparations;
initiating a reaction at a different time points in a plurality of the preparations such that a protein within the cell that
specifically interacts with the member of the capture unit becomes bound to the capture unit via the reactive functional group
to form protein/capture unit complexes;

lysing the cells according to the different time points at the initiating reaction step; and
isolating the protein/capture unit complexes.
US Pat. No. 9,315,778

ENGINEERED EXTRACELLULAR MATRICES CONTROL STEM CELL BEHAVIOR

Purdue Research Foundatio...

1. A tissue graft composition, said composition comprising
a synthetic collagen-based matrix comprising collagen fibrils, wherein the matrix has an elastic or linear modulus of about
0.5 kPa to about 40 kPa; and

a population of mesenchymal stem cells,
wherein the matrix is prepared by a process comprising the step of controlling the elastic or linear modulus to make the stem
cells adipogenic or osteogenic.

US Pat. No. 9,228,761

ELECTROMAGNETIC WAVE CONCENTRATOR AND ABSORBER

PURDUE RESEARCH FOUNDATIO...

1. A solar panel, comprising:
a planar substrate;
a plurality of solar cells mounted to the substrate; and
a plurality of half-cylindrical energy absorber structures mounted to the planar substrate and overlaying the solar cells,
each of the plurality of solar cells disposed at the center of curvature of each of the plurality of half-cylinder energy
absorber structures, the energy absorber structures comprising a material having a spatial variation of permittivity selected
such that the change of the permittivity with a radial distance from the center of curvature of each of the plurality of half-cylindrical
structures is inversely proportional to at least the square of the radius of curvature of each of the plurality of half-cylinder
energy absorber structures.

US Pat. No. 9,808,527

METHODS AND COMPOSITIONS FOR TREATING HIV INFECTIONS

Purdue Research Foundatio...

1. A method for treating a patient with HIV, AIDS, or an AIDS-related disease, the method comprising administering to the
patient a therapeutically effective amount of at least one compound having protease dimerization inhibitory activity and protease
inhibitory activity, wherein the compound is:

and pharmaceutically acceptable salts thereof.
US Pat. No. 9,651,551

METHODS AND SYSTEMS USEFUL FOR FOODBORNE PATHOGEN DETECTION

Purdue Research Foundatio...

1. A method for processing a food sample, comprising:
preparing a liquefied extract of a food sample; and
processing the liquefied extract by hollow fiber membrane filtration to form a concentrate of cells from the liquefied extract,
said processing including:

(i) circulating the liquefied extract in a fluid loop to repeatedly pass the liquefied extract through an interior of one
or more hollow fiber membrane filters so that the liquefied extract is reduced in volume and concentrated in cells over time;
and

(ii) during said circulating, passing an aqueous medium against an exterior surface of the one or more hollow fiber membrane
filters while maintaining a positive pressure gradient from the interior of the hollow fiber membrane to the exterior of the
hollow fiber membrane.

US Pat. No. 9,610,565

CATALYSTS FOR OXIDATIVE COUPLING OF METHANE AND SOLUTION COMBUSTION METHOD FOR THE PRODUCTION OF THE SAME

Purdue Research Foundatio...

1. A method for producing metal oxide catalysts for oxidative coupling of methane reactions, comprising:
measuring predetermined stoichiometric amounts of metal cation contributors to define a predetermined metal cation precursor;
measuring a predetermined amount of reducing fuel;
mixing the predetermined amount of fuel, the predetermined metal cation precursor and water to define an aqueous solution;
evaporating water from the aqueous solution to define a concentrated solution;
igniting the concentrated solution;
combustively reacting the metal cation precursor with the fuel to yield a metal oxide;
flowing methane from a first source over the metal oxide;
flowing oxygen from a second source over the metal oxide;
mixing methane from the first source with oxygen from the second source in the presence of the metal oxide; and
catalyzing an oxidative coupling of methane reaction with the metal oxide;
wherein the methane from the first source and the oxygen from the second source are kept separate until they are introduced
and mixed together in the presence of the metal oxide;

wherein the metal cation precursor is selected from the group consisting of strontium nitrate, aluminum nitrate nonahydrate,
sodium tungsten oxide dihydrate, manganese nitrate tetrahydrate, tetraethoxysilane, and combinations thereof, and wherein
the reducing fuel is selected from the group consisting of glycine, hydrazine, oxalates, and combinations thereof.

US Pat. No. 9,533,975

DUAL-ACTION, UNNATURAL PROLINE-RICH PEPTIDES AS ANTIBIOTIC AGENTS AND METHODS THEREOF

Purdue Research Foundatio...

1. A compound having the structure:

wherein R1 is an alkyl substituent, the alkyl substituent being straight, branched or cyclic, an aryl substituent, an acyl substituent,
an acetyl substituent, a dye, a fluorophore, a conjugating agent, an intracellular directing group or an antimicrobial agent;

wherein R2 and R3 are each independently, a hydrophobic alkyl or aryl moiety; and

wherein n is from about 3 to about 10.
US Pat. No. 9,452,218

COMPOSITIONS AND METHODS FOR DELIVERY OF KINASE INHIBITING PEPTIDES

Purdue Research Foundatio...

1. A composition comprising:
(i) at least one kinase inhibiting peptide incorporated with a nanoparticle, wherein the kinase inhibiting peptide is of Formula
I:

Z1-X1-X2-X3-X4 X5-X6-X7-X8-X9-X10-Z2
wherein Z1 and Z2 are independently absent or are transduction domains;
X1 is KA;
X2 is L;
X3 is selected from the group consisting of V, L, I, A, G, Q, N, S, T, and C;
X4 is R;
X5 is Q;
X6 is L;
X7 is selected from the group consisting of S, A, C, T, and G;
X8 is V;
X9 is A; and
X10 is A or is absent,
wherein the nanoparticle comprises at least one copolymerized monomer having an anionic side chain and at least one additional
copolymerized monomer, wherein the at least one copolymerized anionic monomer is 2-acrylamido-2-methyl-1-propanesulfonic acid
(AMPS), wherein the AMPS is effective to increase drug loading and control drug release;

(ii) a crosslinker, wherein the crosslinker is selected from the group consisting of N,O dimethacryloylhydroxylamine, divinyl
adipate, N,N-Bis(acryloyl)cystamine and N,N?-methylenebisacrylamide; and

(iii) a stabilizer that is coupled to the nanoparticle, wherein the stabilizer is effective to reduce aggregation of the nanoparticles
to maintain the stability of the nanoparticles.

US Pat. No. 9,381,603

INTEGRATED LASER MATERIAL PROCESSING CELL

Purdue Research Foundatio...

1. A process for integrating machining with directed material deposition, comprising:
positioning a primary laser emitter within a workspace;
positioning a powder delivery nozzle within said workspace and adjacent said primary laser emitter;
delivering powder material through said nozzle onto a substrate within said workspace;
melting said material into a solidified layer with heat from a laser beam emitted from said primary laser emitter;
positioning a cutting tool within said workspace, over said substrate and adjacent said solidified layer;
heating said solidified layer adjacent said cutting tool to a temperature that facilitates material removal with said cutting
tool; and

cutting material from said solidified layer with said cutting tool;
wherein said melting and cutting are performed substantially simultaneously.

US Pat. No. 9,333,270

SYNTHESIS AND COMPOSITION OF AMINO ACID LINKING GROUPS CONJUGATED TO COMPOUNDS USED FOR THE TARGETED IMAGING OF TUMORS

Purdue Research Foundatio...

1. A method of optical imaging of a biological tissue that expresses a folate receptor, the method comprising:
(a) contacting the biological tissue with a composition comprising a compound having the formula:

or a pharmaceutically acceptable salt thereof,
or isotopes thereof, wherein:
X is an single amino acid or a single amino acid derivative thereof, wherein the single amino acid or single amino acid derivative
contains an —OH, —NH2 or —SH functional group, and

Y is a dye that has a fluorescence excitation and emission spectra in the near infra red range, wherein Y is represented by
the formula:


wherein, X? is independently selected from the group consisting of O, S, N and C, and
R? is independently selected from the group consisting of CH2 and CH2CH2;

and the compound maintains or enhances the fluorescence of the dye, Y;
(b) allowing time for the compound in the composition to distribute within the biological target;
(c) illuminating the tissue with an excitation light of a wavelength absorbable by the compound; and
(d) detecting the optical signal emitted by the compound.