US Pat. No. 9,469,640

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound of formula (Ia):

or a pharmaceutically acceptable salt thereof,
wherein:
L1 is a bond or —N(H)C(O)—;

each R1 is optionally substituted lower alkyl or optionally substituted heteroaryl;

R2 is hydrogen or halogen;

R4 is hydrogen;

R3 is optionally substituted lower alkyl or optionally substituted aryl;

m is 0, 1, 2, 3, 4, or 5; and
Ar is a monocyclic heteroaryl containing 5 to 6 atoms wherein at least one atom is nitrogen.

US Pat. No. 9,663,517

COMPOSITIONS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A crystalline polymorph Form 1 of Compound I:

that exhibits a powder x-ray diffraction pattern having characteristic peak locations of approximately 4.7, 9.4, 11.0, 12.5,
and 15.4 degrees 2?.

US Pat. No. 9,712,876

IMAGE INFORMATION PROCESSING SERVER

Ripplex Inc., Tokyo (JP)...

1. A server comprising:
a network input and output part configured to connect via a network to a first information terminal and a second information
terminal, the first information terminal being arranged with an input and output part configured to input and output with
an image storage device configured to store image information taken by an imaging terminal; and

a storage part configured to store image identification information for identifying image information, summary image information
having a smaller amount of information than the image information, and device identification information for identifying the
image storage device, the storage part being configured to correlate the image identification information, the summary image
information, and the device identification information;

wherein
the network input and output part is configured to receive the image identification information, the summary image information,
and the device identification information from the first information terminal;

the storage part is configured to store the image identification information, the summary image information, and the device
identification information and to correlate the image identification information, the summary image information, and the device
identification information;

the server is configured to send the summary image information and the image identification information to the second information
terminal;

the server is configured to receive image identification information of summary image information, which is selected by the
second information terminal;

the server is configured to send to the first information terminal the device identification information correlated with the
image identification information, the device identification information being stored in the storage part;

the server is configured to the image information from the image storage device via the first information terminal;
the server is configured to send the image information to the second information terminal;
the storage part is configured to store image information of the external appearance of the image storage device and to correlate
the image information of the external appearance of the image storage device with the device identification information;

the server is configured to send the device identification information stored in the storage part to the second information
terminal; and

the server is configured to make the second information terminal display the image information of the external appearance
of the image storage device correlated with the device identification information on the second information terminal.

US Pat. No. 9,544,986

EXTREME ULTRAVIOLET SOURCE WITH MAGNETIC CUSP PLASMA CONTROL

PLEX LLC, Fall River, MA...

1. An extreme ultraviolet light source comprising: a chamber; a source of droplet targets; one or more lasers focused onto
the droplets in an interaction region; a flowing buffer gas; a reflective collector element to redirect extreme ultraviolet
light to a point on the collector optical axis which is an exit port of the chamber; an annular beam dump disposed around
the collector optical axis; a magnetic field provided by two sets of opposed magnetic field generators that create an asymmetrical
magnetic cusp with magnetic well conforming to the inside shape of the collector, wherein the laser-plasma interaction takes
place at or near the zero magnetic field point of the cusp and heat and target material particles are removed to a beam dump
via magnetically guided plasma flow in a cone-shaped plasma sheet with cone axis parallel to the optical axis.

US Pat. No. 9,447,089

COMPOSITIONS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A solid dispersion comprising Compound I having the formula:
wherein Compound I is molecularly dispersed within a polymer matrix formed by hydroxypropylmethyl cellulose acetate succinate
(HPMCAS) in its solid state, and wherein Compound I is substantially amorphous.

US Pat. No. 9,624,213

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound of formula:
or a pharmaceutically acceptable salt, a hydrate, a solvate, a tautomer, or a stereoisomer thereof.

US Pat. No. 9,856,259

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A compound of formula (I):

or a pharmaceutically acceptable salt, a prodrug, a solvate, a hydrate, a tautomer, a stereosiomer or a deuterated analog
thereof,

wherein
(i) Y1 and Y2 are N, Y3 is CR2, Y4 is CH or N and Y5 is CH; or

(iii) Y1 is N, Y2 is CH, Y3 is CR2, Y4 is N and Y5 is N; or

(iv) Y1 is C, Y2 is CH, Y3 is NR2, Y4 is N and Y5 is N;

L is —CHR5, wherein R5 is H, D, halogen, —OH, C1-6alkyl, deuterated C1-6alkyl, C2-6-alkenyl, C2-6alkynyl, aryl, aryl-C1-4alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, heterocycloalkyl heterocycloalkyl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, C1-6haloalkyl or C1-6-haloalkoxy, wherein the aliphatic or aromatic portion of R5 is further optionally substituted with from 1-3 Rc members, wherein each Rc member is independently halogen, CN, —OH, —NH2, —NO2, —C(O)OH, —CH?CH2, —C?CH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —ORd, —SRd, —OC(O)Rd, —OC(S)Rd, —P(?O)HRd, —P(?O)RdRd, —PH(?O)ORd, —P(?O)(ORd)2, —OP(?O)(ORd)2, —C(O)Rd, —C(S)Rd, —C(O)ORd, —C(S)ORd, —S(O)Rd, —S(O)2Rd, —C(O)NHRd, —C(S)NHRd, —C(O)NRdRd, —C(S)NRdRd, —S(O)2NHRd, —S(O)2NRdRd, —C(NH)NHRd, —C(NH)NRdRd, —NHC(O)Rd, —NHC(S)Rd, —NRdC(O)Rd, —NRdC(S)Rd, —NHS(O)2Rd, —NRdS(O)2Rd, —NHC(O)NHRd, —NHC(S)NHRd, —NRdC(O)NH2, —NRdC(S)NH2, —NRdC(O)NHRd, —NRdC(S)NHRd, —NHC(O)NRdRd, —NHC(S)NRdRd, —NRdC(O)NRdRd, —NRdC(S)NRdRd, —NHS(O)2NHRd, —NRdS(O)2NH2, —NRdS(O)2NHRd, —NHS(O)2NRdRd, —NRdS(O)2NRdRd, —NHRd, —NRdRd or Rd, wherein each Rd is independently C1-6alkyl or aryl; or two Rd groups when attached to the same nitrogen atom are taken together with the nitrogen atom to which they are attached form a
4- to 6-membered ring: wherein each Rd is further optionally substituted with from 1-3 Re, wherein each Re is independently halogen, CN, —OH, —NH2, —NO2, —C(O)OH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —ORf, —SRf, —OC(O)Rf, —OC(S)Rf, —P(?O)HRf, —P(?O)RfRf, —PH(?O)ORf, —P(?O)(ORf)2, —OP(?O)(ORf)2, —C(O)Rf, —C(S)Rf, —C(O)ORf, —C(S)ORf, —S(O)Rf, —S(O)2Rf, —C(O)NHRf, —C(S)NHRf, —C(O)NRfRf, —C(S)NRfRf, —S(O)2NHRf, —S(O)2NRfRf, —C(NH)NHRf, —C(NH)NRfRf, —NHC(O)Rf, —NHC(S)Rf, —NRfC(O)Rf, —NRfC(S)Rf, —NHS(O)2Rf, —NRfS(O)2Rf, —NHC(O)NHRf, —NHC(S)NHRf, —NRfC(O)NH2, —NRfC(S)NH2, —NRC(O)NHRf, —NRfC(S)NHRf, —NHC(O)NRfRf, —NHC(S)NRfRf, —NRfC(O)NRfRf, —NRfC(S)NRfRf, —NHS(O)2NHRf, —NRfS(O)2NH2, —NR'S(O)2NHRf, —NHS(O)2NRfRf, —NRfS(O)2NRfRf, —NHRf, —NRfRf or Rf, wherein each Rf is independently C1-6alkyl; or two Rf groups when attached to the same nitrogen atom are taken together with the nitrogen atom to which they are attached form a
4- to 6-membered ring;

R1 is optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted heteroaryl or optionally substituted
heterocycloalkyl;

R2 is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aryl-C1-2alkyl or optionally substituted heteroaryl-C1-2alkyl;

R3 is a 5-membered heteroaryl having from 1-4 heteroatoms as ring members that are each independently O, N or S and wherein the
heteroaryl is substituted with from 1-2 C1-2alkyl, which is optionally substituted with from 1-3 members that are each independently halogen, OH or CN; and

the notation is a single bond or a double bond to maintain ring A being aromatic.

US Pat. No. 9,169,250

COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR

Plexxikon Inc., Berkeley...

1. A pharmaceutical composition comprising a compound of formula:
and a pharmaceutically acceptable carrier, diluent or excipient.

US Pat. No. 9,096,593

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound having Formula II':

or a salt, a tautomer or a stereoisomer thereof,
wherein:
R6 is selected from the group consisting of methyl, —C(O)—N(H)—R14, and —N(H)—C(O)—R15;

R14 is lower alkyl;

R15 is lower alkyl; and

(i) R16 is H and R17 is —F, —Cl, —Br, lower alkyl, fluoro substituted lower alkyl, methoxy substituted lower alkyl, —CN or —O—R20; or

(ii) R17 is H and R16 is —F, —Cl, —Br, lower alkyl, fluoro substituted lower alkyl, methoxy substituted lower alkyl, —CN or —O—R20;

R18 is —F or —Cl;

R19 is H; and

R20 is lower alkyl, fluoro substituted lower alkyl, methoxy substituted lower alkyl, or cycloalkyl.

US Pat. No. 9,150,570

SYNTHESIS OF HETEROCYCLIC COMPOUNDS

Plexxikon Inc., Berkeley...

1. A compound of formula (I):

wherein:
Q is F or H;
P1 is H, 9-fluorenylmethoxycarbonyl, t-butoxycarbonyl, trimethylsilyl, or t-butyldiphenylsilyl;

P2 is 2,6-dichlorophenylcarbonyl; and

L1 is Br, Cl, I, R1—SO2O— or R2C(O)O—; wherein R1 and R2 are each optionally substituted aryl or optionally substituted C1-6alkyl.

US Pat. No. 9,128,512

IMAGE DATA PROCESSING SERVER

RIPPLEX INC., Tokyo (JP)...

1. A method of operating a server providing a network service comprising:
receiving from a first imaging terminal of a first user a first image data group comprised from a plurality of image data
and a first imaging terminal ID for uniquely specifying the first imaging terminal;

receiving a first scrambled PID and a second scrambled PID from a server of a bridge service in response to sending a first
image ID for uniquely specifying a first image data being one image data in the first image data group, a second image ID
for uniquely specifying a second image data being another image data, and the first imaging terminal ID to the server of the
bridge service, the first scrambled PID being generated based on the first image ID and the first imaging terminal ID, the
second scrambled PID being generated based on the second image ID and the first imaging terminal ID, the server of the bridge
server correlating the first scrambled PID with the first imaging terminal ID, the server of the bridge server correlating
the second scrambled PID with the first imaging terminal ID;

storing in a first storage means the first scrambled PID and the first image data with the first scrambled PID correlated
with the first image data;

storing in the first storage means the second scrambled PID and the second image data with the second scrambled PID correlated
with the second image data;

receiving a first user ID for specifying the first user among users of the network service and the first imaging terminal
ID from a first data terminal of the first user;

storing in a second storage means the first user ID and the first imaging terminal ID with the first user ID correlated with
the first imaging terminal ID;

searching in the second storage means using the first user ID as a search key and extracting the first imaging terminal ID
as a search result;

receiving the first scrambled PID and the second scrambled PID from the server of the bridge service in response to sending
the extracted first imaging terminal ID to the server of the bridge service, the first scrambled PID being correlated with
the extracted first imaging terminal ID, the second scrambled PID being correlated with the extracted first imaging terminal
ID;

searching in the first storage means using the received first scrambled PID as a search key and extracting the first image
data as a search result;

searching in the first storage means using the received second scrambled PID as a search key and extracting the second image
data as a search result;

generating a first summary image, which represents the extracted first image data, having a smaller amount of data than the
first image data;

generating a second summary image, which represents the extracted second image data, having a smaller amount of data than
the second image data;

storing in a third storage means the first summary image and the first scrambled PID with the first summary image correlated
with the first scrambled PID;

storing in the third storage means the second summary image and the second scrambled PID with the second summary image correlated
with the second scrambled PID; and sending the first summary image and the second summary image to the first data terminal.

US Pat. No. 9,260,437

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

4. A composition comprising a pharmaceutically acceptable carrier; and a compound according to claim 1.

US Pat. No. 9,814,714

KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method of treating or inhibiting a BRAF V600 mutation or BRAF fusion mutation related disease or condition, without activating
the MAPK pathway or inducing expression of MAPK pathway genes in cells harboring wild-type BRAF, in a subject suffering from
or at risk for a said disease or condition, comprising administering to the subject in need thereof a therapeutically effective
amount of a compound of Formula I:

or a pharmaceutically acceptable salt, isomer, tautomer or deuterated form thereof.

US Pat. No. 9,487,515

COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR

Plexxikon Inc., Berkeley...

1. A method for treating a subject suffering from a c-kit and/or c-fms mediated disease or condition, said method comprising
administering to the subject an effective amount of a compound in combination with an immunotherapy, wherein the compound
is:
or a salt, a prodrug, or a tautomer thereof.

US Pat. No. 9,873,700

COMPOUNDS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound having formula (Ic-1a)

or a pharmaceutically acceptable salt, a solvate, a tautomer or a stereoisomer thereof, wherein:
R16 is hydrogen, optionally substituted aryl or optionally substituted C1-6alkyl;

R19 is hydrogen or 2-(methoxycarbonylamino)propyl;

R4 is hydrogen, fluoro, chloro, —CH3, —CN, or —CF3; and

R1 and R2 are each independently optionally substituted alkyl.

US Pat. No. 9,745,298

SYNTHESIS OF A COMPOUND THAT MODULATES KINASES

Plexxikon Inc., Berkeley...

1. A compound of formula III:
or a salt thereof, wherein each PG independently is a protecting group wherein the protecting group is independently selected
from the group consisting of tert-butyloxycarbonyl, benzyloxycarbonyl and 9-fluorenylmethoxycarbonyl.

US Pat. No. 9,550,768

KINASE MODULATION AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method for treating a subject suffering from acute myeloid leukemia (AML), said method comprising administering to the
subject an effective amount of a compound having the formula:

or a pharmaceutically acceptable salt, tautomer or isomer thereof, wherein the subject has an FMS-like tyrosine kinase (Flt3)
gene with an internal tandem duplication (ITD) mutation.

US Pat. No. 9,358,235

KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method for treating a subject suffering from pigmented villonodular synovitis (PVNS) or tenosynovial giant cell tumor
(TGCT), said method comprising administering to the subject an effective amount of a compound having the formula:

or a pharmaceutically acceptable salt, a prodrug, tautomer or an isomer thereof.

US Pat. No. 9,864,555

IMAGE DATA PROCESSING SERVER

Ripplex Inc., Tokyo (JP)...

2. A system connected to an information terminal arranged with an input/output means, a first server, a second server and
a third server via a network, the system comprising:
the first server correlating and storing a first real image information with a first image ID information in a first table
included in the first server;

the second server correlating and storing a second real image information with a second image ID information in a second table
included in the second server;

the third server correlating a first storage ID information specifying the first server with a first server image representing
the first server, correlating a second storage ID information specifying the second server with a second server image representing
the second server, and storing the first storage ID information and the second storage ID information in a third table included
in the third server;

the third server correlating a first summary image information being reduced from the first real image information with the
first image ID information and the first storage ID information, correlating a second summary image information being reduced
from the second real image information with the second image ID information and the second storage ID information and storing
the first summary image information and the second summary image information in a fourth table included in the third server;

upon the third server receiving a request for an image list from the information terminal via the network, the third server
correlating the first server image extracted by searching the third table using the first storage ID information as a search
key with the first summary image information and the first image ID information, and correlating the second server image extracted
by searching the third table using the second storage ID information as a search key with the second summary image information
and the second image ID information, the server sending the first server image and the second server image to the information
terminal via the network; and

the input/output means of the information terminal correlating and displaying the first summary image information with the
first server image, and the second summary image information with the second server image respectively.

US Pat. No. 9,844,539

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound of formula (Ia):

or a pharmaceutically acceptable salt thereof,
wherein:
L1 is a bond or —N(H)C(O)—;

each R1 is optionally substituted lower alkyl or optionally substituted heteroaryl;

R2 is hydrogen or halogen;

R4 is hydrogen;

R3 is optionally substituted lower alkyl or optionally substituted aryl;

m is 0, 1, 2, or 3; and
Ar is a monocyclic heteroaryl containing 5 to 6 atoms wherein at least one atom is nitrogen.

US Pat. No. 9,440,969

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound having the chemical structure of Formula I,
or a pharmaceutically acceptable salt or a tautomer or a stereoisomer thereof,wherein:
R1 is aryl substituted with one or two trifluoromethyl, trifluoromethoxy, C1-6 alkyl or halogen;

Ar is selected from the group consisting of:

wherein:
W represents the point of attachment to the 5-position of the pyrrolo[2,3-b]pyridine ring of Formula I, wherein W is attached
at any available position of the 6-membered phenyl ring portion of Ar;

X represents the point of attachment to the 5-position of the pyrrolo[2,3-b]pyridine ring of Formula I, wherein X is attached
at any available position of the 6-membered ring portion of Ar;

Y represents the point of attachment to the 5-position of the pyrrolo[2,3-b]pyridine ring of Formula I, wherein Y is attached
at any available position of the bicyclic ring of Ar;

R24, R26, R28, R30, R32, R34, R36, R70 and R72 are selected from the group consisting of hydrogen, —C(O)—R45, —S(O)2—R46, and C1-6 alkyl, wherein C1-6 alkyl is optionally independently substituted with one or more fluoro, or, when R24, R26, R28, R30, R32, R34, and/or R36 is C2-6alkyl, R24, R26, R28, R30, R32, R34, and R36 are each optionally independently substituted with one or more C1-6 alkoxy, mono-alkylamino, di-alkylamino or cycloalkylamino;

each R25, R27, R29, R31, R33, R35, R37, R38, R39, R40, R41, R42, R43, R44, R71 and R73 are independently selected from the group consisting of —CN, —C(O)—R45, —S(O)2—R46, —O—R47, —N(R48)—R49, fluoro, chloro, C1-6 alkyl, and cycloalkylamino, and are attached at any available position of the bicyclic ring of Ar, wherein C1-6 alkyl is optionally independently substituted with one or more fluoro C1-6 alkoxy, mono-alkylamino, di-alkylamino or cycloalkylamino;

each R45 is independently selected from the group consisting of —O—R47, —NH2, C1-6 alkyl, mono-alkylamino, di-alkylamino, and cycloalkylamino;

each R46 are independently selected from the group consisting of —NH2, C1-6 alkyl, mono-alkylamino, di-alkylamino, and cycloalkylamino;

each R47 is independently or C1-6 hydrogen alkyl, wherein C1-6 alkyl is optionally independently substituted with one or more fluoro, or, when R47 is C2-6 alkyl, R47 is optionally substituted with one or more C1-6 alkoxy, mono-alkylamino, di-alkylamino or cycloalkylamino;

each R48 and R49 are independently selected from the group consisting of hydrogen, C1-6 alkyl, or cycloalkyl, wherein C1-6 alkyl is optionally independently substituted with C1-6 alkoxy, mono-alkylamino, di-alkylamino, or cycloalkylamino; and

each p is independently 0, 1, 2 or 3.
US Pat. No. 9,102,526

NODE POLYPEPTIDES FOR NANOSTRUCTURE ASSEMBLY

IMIPLEX LLC, Yardley, PA...

1. A nanostructure node, comprising
a multimeric protein having at least one polypeptide chain and a known three-dimensional structure with Cn symmetry with a
Cn symmetry axis or with Dn symmetry with a Dn symmetry axis,

wherein the multimeric protein has stable tertiary structure at a temperature of 70° C. or greater and a modified amino acid
sequence comprising a specific binding site positioned with predefined stoichiometry and orientation for attachment of a nanostructure
strut,

wherein the specific binding site comprises a pair of reactive amino acid residues, each reactive amino acid residue covalently
attached to a moiety independently selected from the group consisting of a biotin group, a biotin derivative group, iminobiotin,
an adenosine triphosphate (ATP) group, an adenosine triphosphate (ATP) derivative group, a nucleobase group, a nucleobase
derivative group, a nucleoside group, a nucleoside derivative group, a nucleotide group, and a nucleotide derivative group,
so that a pair of moieties are attached to the specific binding site,

wherein the nanostructure strut has three dyad axes and two pairs of moiety binding sites, the first pair of moiety binding
sites related to the second pair of moiety binding sites by a dyad axis, the first moiety binding site of the first pair related
to the second moiety binding site of the first pair by a dyad axis, and the first moiety binding site of the second pair related
to the second moiety binding site of the second pair by a dyad axis,

wherein the pair of moieties attached to the specific binding site of the multimeric protein can bind with the first or second
pair of moiety binding sites on the nanostructure strut, so that the Cn or Dn symmetry axis of the multimeric protein is parallel
to within 5 degrees to one of the three dyad axes of the nanostructure strut.

US Pat. No. 9,285,363

METHOD OF PROTEIN NANOSTRUCTURE FABRICATION

IMIPLEX LLC, Yardley, PA...

1. A protein nanostructure comprising,
a protein node;
a selectively patterned surface comprising at least one fixation site, the protein node bound with the at least one fixation
site

a second protein node,
wherein the protein node comprises an interaction domain and the second protein node comprises a second interaction domain
and

wherein the interaction domain of the protein node interacts with the second interaction domain of the second protein node;
a streptavidin bound to an adaptor protein comprising a binding domain; and
an antibody protein,
wherein the antibody protein is bound to the binding domain and
wherein the streptavidin is bound to the protein node.

US Pat. No. 9,695,169

SYNTHESIS OF HETEROCYCLIC COMPOUNDS

Plexxikon Inc., Berkeley...

1. A compound of formula (I):

wherein:
Q is F or H;
P1 is H, 9-fluorenylmethoxycarbonyl, t-butoxycarbonyl, trimethylsilyl or t-butyldiphenylsilyl;

P2 is R3—C(O)— or R4O—C(O)—, wherein R3 and R4 are each C1-6alkyl, aryl, heteroaryl, aryl-C1-2alkyl, heteroaryl-C1-2alkyl, C3-10cycloalkyl, C3-10cycloalkyl-C1-2alkyl, ethynyl, allyl, or vinyl, each of which is optionally substituted; and

L1 is Br, Cl, I, R1—SO2O— or R2C(O)O—; wherein R1 and R2 are each optionally substituted aryl, optionally substituted aryl-C1-4alkyl, or optionally substituted C1-6alkyl.

US Pat. No. 9,682,981

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

8. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

US Pat. No. 9,617,267

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method for alleviating or ameliorating one or more symptoms of melanoma or colon adenocarcinoma in a subject in need
thereof, said method comprising administering to said subject an effective amount of a compound of Formula I:

or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein
X is —N?;
Y is —N(R3)(R4); wherein:

R3 is hydrogen and R4 is selected from the group consisting of (i) hydrogen, —OR8 and lower alkyl optionally substituted with one or more R11; (ii) cycloalkyl optionally substituted with one or more R12; (iii) heterocycloalkyl optionally substituted with one or more R13; (iv) aryl optionally substituted with one or more R14; and (v) heteroaryl optionally substituted with one or more R15; or

R3 and R4 are both lower alkyl; or

R3 and R4 combine with the nitrogen atom to which they are attached to form cycloalkylamino;

R1 is selected from the group consisting of lower alkyl, haloalkyl, haloalkoxy, fluoro substituted lower alkyl, cycloalkyl optionally
substituted with one or more R7, heterocycloalkyl, mono-alkylamino, di-alkylamino, cycloalkylamino, heterocycloalkylamino, aryl optionally substituted with
one or more R6 and heteroaryl optionally substituted with one or more R7;

R2 is hydrogen, fluoro, chloro, or lower alkyl optionally substituted with one or more fluorine;

each R6, when present, is independently selected from the group consisting of fluoro, chloro, —CN, —NO2, lower alkyl, fluoro substituted lower alkyl, lower alkoxy, fluoro substituted lower alkoxy, —C(O)—O—R18, —N(H)—C(O)—R19, and heteroaryl optionally substituted with one or more lower alkyl;

each R7, when present, is independently selected from the group consisting of lower alkyl, fluoro substituted lower alkyl, lower
alkoxy, —C(O)—O—R20, and heteroaryl optionally substituted with one or more lower alkyl;

R8 is hydrogen, lower alkyl optionally substituted with one or more fluorine, or, when R8 is a C2-6 alkyl, said alkyl may optionally be substituted with one or more R21; cycloalkyl optionally substituted with one or more R21, or heterocycloalkyl optionally substituted with one or more R21;

each R11, when present, is independently selected from the group consisting of fluoro, —OH, lower alkoxy, fluoro substituted lower
alkoxy, —NH2, mono-alkylamino, di-alkylamino, cycloalkylamino, heterocycloalkylamino, cycloalkyl optionally substituted with one or more
R12, heterocycloalkyl optionally substituted with one or more R13, aryl optionally substituted with one or more R14, and heteroaryl optionally substituted with one or more R15;

each R12, when present, is independently selected from the group consisting of fluoro, lower alkyl, fluoro substituted lower alkyl,
—OH, lower alkoxy, fluoro substituted lower alkoxy, —NH2, mono-alkylamino, di-alkylamino, cycloalkylamino, heterocycloalkylamino, —N(H)—C(O)—R22, —N(H)—S(O)2—R23, C(O)—R24, and S(O)2—R25;

each R13, when present, is independently selected from the group consisting of fluoro, —OH, lower alkoxy, fluoro substituted lower
alkoxy, —NH2, mono-alkylamino, di-alkylamino, cycloalkylamino, heterocycloalkylamino, —N(H)—C(O)—R26, —N(H)—S(O)2—R27, C(O)—R28, S(O)2—R29, and lower alkyl optionally substituted with one or more R30;

each R14 and R15, when present, are independently selected from the group consisting of fluoro, chloro, —OH, —NH2, —CN, —NO2, —N(H)—C(O)—R31, —N(H)—S(O)2—R32, C(O)—R33, S(O)2—R34, lower alkyl, fluoro substituted lower alkyl, lower alkoxy, fluoro substituted lower alkoxy, mono-alkylamino, di-alkylamino,
cycloalkylamino, heterocycloalkylamino, aryl optionally substituted with one or more R35, and heteroaryl optionally substituted with one or more R36;

each R18 and R20, when present, are independently hydrogen, lower alkyl or fluoro substituted lower alkyl;

each R19, R22, R23, R26, R27, R31 and R32, when present, are independently lower alkyl or fluoro substituted lower alkyl;

each R21, when present, is fluoro, —OH, lower alkoxy, —NH2, mono-alkylamino, di-alkylamino, cycloalkylamino, or heterocycloalkylamino;

each R24, R25, R28, R29, R33, and R34, when present, are independently lower alkyl, fluoro substituted lower alkyl, —OH, lower alkoxy, fluoro substituted lower
alkoxy, —NH2, mono-alkylamino, di-alkylamino, cycloalkylamino, or heterocycloalkylamino;

each R30, when present, is independently fluoro, aryl optionally substituted with one or more R35 or heteroaryl optionally substituted with one or more R36;

each R35 and R36, when present, are independently selected from the group consisting of fluoro, chloro, —OH, —NH2, —CN, —NO2, lower alkyl, fluoro substituted lower alkyl, lower alkoxy, fluoro substituted lower alkoxy, mono-alkylamino, di-alkylamino,
cycloalkylamino, and heterocycloalkylamino.

US Pat. No. 9,771,369

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

14. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or excipient.

US Pat. No. 9,730,918

KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method for treating a subject suffering from malignant peripheral nerve sheath tumors (MPNST), said method comprising
administering to the subject sirolimus and an effective amount of a compound having the formula:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,771,363

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A compound of Formula (I):

or a pharmaceutically acceptable salt, a tautomer, a stereoisomer or a deuterated analog thereof, wherein:
R1 is cyano, halo, or (C1-C3)alkyl optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, methyl, ethyl,
methoxy and ethoxy; and

X, when present, is halo.

US Pat. No. 9,942,955

LED LAMP USING SWITCHING CIRCUIT

AMOSENSE CO., LTD. (CHEON...

1. An LED lamp using a switching circuit, comprising:a first input base on which a first terminal and a second terminal are formed;
a first rectifier circuit, which includes one or more diodes and is connected with the first terminal and the second terminal of the first input base;
an LED circuit, which includes one or more LEDs and is connected with the first rectifier circuit;
a second rectifier circuit, which includes one or more diodes and is connected with the LED circuit;
a second input base on which a third terminal and a fourth terminal are formed, the third terminal and the fourth terminal being connected with the second rectifier circuit; and the switching circuit, connected with at least one line that connects the first rectifier circuit and the LED circuit,
wherein the switching circuit comprises:
a switching element, a first end of which is connected with the first rectifier and a second end of which is connected with the LED circuit;
a driving element connected in parallel with the switching element in such a way that a first end thereof is connected with the first end of the switching element and a second end thereof is connected with the second end of the switching element and the LED circuit;
a photo-coupler, a first end of which is connected with the first end of the switching element and a second end of which is connected with the second end of the switching element and the second end of the driving element;
a resistor, a first end of which is connected with the second end of the switching element, the second end of the driving element and the second end of the photo-coupler and a second end of which is connected with the LED circuit; and
a light-emitting diode connected in parallel with the resistor in such a way that a first end thereof is connected with the first end of the resistor and a second end thereof is connected with the second end of the resistor.

US Pat. No. 9,822,109

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A compound of formula (III):

or a pharmaceutically acceptable salt, solvate, a tautomer, a stereoisomer or a deuterated analog thereof,
Y1 is N;

R1 is optionally substituted C1-6 alkyl, optionally substituted deuterated C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C3-6-cycloalkyl, optionally substituted cycloalkenyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl,
optionally substituted C3-6-cycloalkylalkyl, optionally substituted aryl-C1-4 alkyl, optionally substituted heteroarylalkyl, or optionally substituted heterocycloalkylalkyl,

R2 is H;

R3 is H, halogen, —CN, optionally substituted C1-6alkyl, optionally substituted deuterated C1- 6alkyl, optionally substituted aryl, optionally substituted aryl-C1-4alkyl, optionally substituted heteroaryl, optionally substituted heteroaryl-C1-4alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted C3-8 cycloalkenyl, optionally substituted C3-8 cycloalkyl-C1-4 alkyl, optionally substituted C2-6 alkynyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkyl-C1-4alkyl or Rj;

R4 is H;

R5 is:

each of which is optionally substituted with from 1-2 R11;
wherein the wavy line indicates the point of attachment to the rest of molecule and
each R11 is independently D, halogen, C1-6alkyl, deuterated C1-6alkyl, C1-4haloalkyl, C1-4haloalkoxy or CN;

L is —C(R6)(R7)—, —C(O)—, —S(O)—, —S—, —P(O)(Ra)—, —CH?C(Rb)—, or —Si(Rc)(Rc);

R6 is H or D;

R7 is H, D, halogen, —OH, C1-6alkyl, deuterated C1-6alkyl, C2-6alkenyl, C2-6alkynyl, aryl, aryl-C1-4 alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, heterocycloalkyl, heterocycloalkyl-C1-4alkyl, heteroaryl, heteroarylalkyl, C1-6haloalkyl, C1-6haloalkoxy, —ORd, —NRdRd, —C(O)ORd, —OC(O)Rd, —(O)C(O)ORd, —C(O)Rd, —NHC(O)Rd, —C(O)NRdRd, —SO2Rd, —NHSO2Rd or —SO2NRdRd,

wherein R7 is further optionally substituted with from 1-3 Rh groups;

Ra is optionally substituted C1-6alkyl, optionally substituted aryl or optionally substituted heteroaryl; and

Rb is H or C1-6alkyl;

each Rc is independently selected from H, C1-6alkyl or C1-6alkoxy;

each Rd is independently H, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl or aryl;

each Rh is independently halogen, —CN, —OH, —NH2, —NO2, —CH?C(Rk)(Rk), —C(O)OH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —ORi, —SRi, —OC(O)Ri, —OC(S)Ri, —P(?O)HRi, —P (?O)RiRi, —PH(?O)ORi,—P(?O)(ORI)2, —OP(?O)(ORi)2, —C(O)H, —O(CO)ORi, —C(O)Ri, —C(S)Ri, —C(O)ORi, —C(S)ORi, —S(O)Ri, —S(O)2Ri, —C(O)NHRi, —C(S)NHRi, —C(O)NRiRi, —C(S)NRiRi, —S(O)2NHRi, —S(O)2NRiRi, —C(NH)NHRi, —C(NH)NRiRi, —NHC(O)Ri, —NHC(S)Ri, —NRiC(O)Ri, —NRiC(S)Ri, —NHS(O)2Ri, —NRiS(O)2Ri, —NHC(O)NHRi, —NHC(S)NHRi, —NRiC(O)NH2, —NRiC(S)NH2, —NRiC(O)NHRi, —NRiC(S)NHRi, —NHC(O)NRiRi, —NHC(S)NRiRi, —NRiC(O)NRiRi, —NRiC(S)NRiRi, —NHS(O)2NHRi, —NRiS(O)2NH2, —NRiS(O)2NHRi, —NHS(O)2NRiRi, —NRiS(O)2NRiRi, Ri, —NHRi or —NRiRi , and

each Ri is independently C1-6alkyl, aryl, aryl-C1-2alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, heterocycloalkyl or heterocycloalkyl-C1-4alkyl;

Rj is halogen, —CN, —OH, —NH2, —NO2, —C(O)OH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —CH?C(Rk)(Rk), —ORk, —SRk, —OC(O)Rk, —OC(S)Rk, —P(?O)HRk, —P(?O)RkRk, —PH(?O)ORk, —P(?O)(ORk)2, —OP(?O)(ORk)2, —C(O)H, —O(CO)ORk, —C(O)Rk, —C(S)Rk, —C(O)ORk, —C(S)ORk, —S(O)Rk, —S(O)2Rk, —C(O)NHRk, —C(S)NHRk, —C(O)NRkRk, —C(S)NRkRk, —S(O)2NHRk, —S(O)2NRkRk, —C(NH)NHRk, —C(NH)NRkRk, —NHC(O)Rk, —NHC(S)Rk, —NRkC(O)Rk, —NRkC(S)Rk, —NHS(O)2Rk, —NRkS(O)2Rk, —NHC(O)NHRk, —NHC(S)NHRk, —NRkC(O)NH2, —NRkC(S)NH2, —NRkC(O)NHRk, —NRkC(S)NHRk, —NHC(O)NRkRk, —NHC(S)NRkRk, —NRkC(O)NRkRk, —NRkC(S)NRkRk, —NHS(O)2NHRk, —NRkS(O)2NH2, —NRkS(O)2NHRk, —NHS(O)2NRkRk, —NRkS(O)2NRkRk, —NHRk or —NRkRk; and

each Rk is independently H, C1-6alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, cycloalkyl or cycloalkylalkyl;
or two Rk groups when attached to the same carbon or nitrogen atom are taken together to form a 3- to 6- membered carbocyclic ring or
3- to 8- membered heterocyclic ring having from 1-2 heteroatoms as ring members selected from O, N and S, wherein the nitrogen
or sulfur ring atoms are optionally oxidized, and wherein Rk is optionally substituted with from 13 Rh.

US Pat. No. 9,802,932

SOLID FORMS OF A COMPOUND MODULATING KINASES

Plexxikon Inc., Berkeley...

1. A crystalline form of Compound I:

which is Compound I Form A, characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 7.1, 22.9 and 27.6
°2? as determined on a diffractometer usino Cu—K? radiation.

US Pat. No. 9,718,847

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A compound having formula (Va):

or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof,
wherein:
R2 is H;

R4 is H;

R6 is H;

R7 is H, —OH, C1-6 alkyl, aryl, heteroaryl, cycloalkyl, or heterocycloalkyl;

R1 is heteroaryl optionally substituted with from 1-3 Rj groups;

each Rj independently selected from halogen, —CN, —OH, —NH2, —NO2, —C(O)OH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —CH?C(Rk)(Rk), —ORk, —SRk, —OC(O)Rk, —OC(S)Rk, —P(?O)HRk, —P(?O)RkRk, —PH(?O)ORk, —P(?O)(ORk)2, —OP(?O)(ORk)2, —C(O)H, —O(CO)ORk, —C(O)Rk, —C(S)Rk, —C(O)ORk, —C(S)ORk, —S(O)Rk, —S(O)2Rk, —C(O)NHRk, —C(S)NHRk, —C(O)NRkRk, —C(S)NRkRk, —S(O)2NHRk, —S(O)2NRkRk, —C(NH)N HRk, —C(NH)NRkRk, —NHC(O)Rk, —NHC(S)Rk, —NRkC(O)Rk, —NRkC(S)Rk, —NHS(O)2Rk, —NRkS(O)2Rk, —NHC(O)NHRk, —NHC(S)NHRk, —NRkC(O)NH2, —NRkC(S)NH2, —NRkC(O)NHRk, —NRkC(S)NHRk, —NHC(O)NRkRk, —NHC(S)NRkRk, —NRkC(O)NRkRk, —NR kC(S)NRkRk, —NHS(O)2NHRk, —NRkS(O)2NH2, —NRkS(O)2NHRk, —NHS(O)2NRkRk, —NRkS(O)2NRkRk, —NHRk or —NRkRk;

each Rk is independently H, C1-6alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, cycloalkyl or cycloalkylalkyl;
or

two Rk groups when attached to the same carbon or nitrogen atom are taken together to form a 3- to 6-membered carbocyclic ring or
3- to 8-membered heterocyclic ring having from 1-2 heteroatoms as ring members selected from O, N or S, wherein the nitrogen
or sulfur ring atoms are optionally oxidized;

R3 is H, halogen, —CN, optionally substituted C1-6alkyl, optionally substituted deuterated C1-6alkyl, optionally substituted aryl, optionally substituted aryl-C1-4alkyl, optionally substituted heteroaryl, optionally substituted heteroaryl-C1-4alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted C3-8 cycloalkyl-C1-4alkyl, optionally substituted heterocycloalkyl, or optionally substituted heterocycloalkyl-C1-4alkyl; and

R5 is


 optionally substituted with from 1 to 2 R11 groups independently selected from D, halogen, C1-6alkyl, C1-4haloalkyl, C1-4haloalkoxy or —CN;

wherein the wavy line indicates the point of attachment to the rest of molecule.

US Pat. No. 9,776,998

SYNTHESIS OF HETEROCYCLIC COMPOUNDS

Plexxikon Inc., Berkeley...

1. A compound of formula (I):

or a pharmaceutically acceptable salt, a solvate, a tautomer or a stereoisomer thereof, wherein:
Q is F or H;
P1 is H,


R1 is H or halogen;

n is 0, 1 or 2;
m is 1 or 2;
P2 is —C(O)—R3 or —C(O)—OR4;

R3 is C1-6alkyl, aryl, heteroaryl, aryl-C1-2alkyl, heteroaryl-C1-2alkyl, C3-10cycloalkyl, C3-10cycloalkyl-C1-2alkyl, ethynyl, allyl or vinyl, each of which is optionally substituted with 1-3 Ra groups;

R4 is C1-6alkyl, aryl, heteroaryl, aryl-C1-2alkyl, heteroaryl-C1-2alkyl, C3-10cycloalkyl, C3-10cycloalkyl-C1-2alkyl, ethynyl, allyl or vinyl, each of which is optionally substituted with 1-3 Ra groups; and

each Ra group is independently halogen, C1-6alkyl, fluoro substituted C1-6alkyl, fluoro substituted C1-6alkoxy, aryl, heteroaryl, C1-6alkoxy, —CN, —NO2, —OH, —C(O)—O—C1-6alkyl, —CH?CH2 or —SiMe3, wherein the aliphatic or aromatic portion of Ra is further optionally substituted with from 1-3 Rb groups, wherein each Rb group is independently halogen, C1-6alkyl, C1-6alkoxy, —CN, —NO2 or —OH.

US Pat. No. 9,301,380

EXTREME ULTRAVIOLET SOURCE WITH MAGNETIC CUSP PLASMA CONTROL

PLEX LLC, Fall River, MA...

1. An extreme ultraviolet light source comprising: a chamber; a source of droplet targets; one or more lasers focused onto
the droplets in an interaction region; a flowing buffer gas; one or more reflective collector elements to redirect extreme
ultraviolet light to a point on the common collector optical axis which is an exit port of the chamber; an annular array of
plasma beam dumps disposed around the collector optical axis; a magnetic field provided by two sets of opposed, symmetrical
field coils that carry equal but oppositely directed currents to create a symmetrical magnetic cusp, wherein the laser-plasma
interaction takes place at or near the zero magnetic field point of the cusp and heat is removed via radial plasma flow in
a 360 degree angle range perpendicular to the optical axis toward the annular array of plasma beam dumps.

US Pat. No. 9,155,178

EXTREME ULTRAVIOLET SOURCE WITH MAGNETIC CUSP PLASMA CONTROL

PLEX LLC, Fall River, MA...

1. An extreme ultraviolet light source comprising: a chamber; a source of droplet targets; one or more lasers focused onto
the droplets in an interaction region; a flowing buffer gas; a reflective collector element to redirect extreme ultraviolet
light to a point on the collector optical axis which is an exit port of the chamber; a plasma sheet disposed perpendicular
to the collector optical axis, wherein the buffer gas is introduced into the space between the plasma sheet and the collector
element and is maintained via the pumping action of the plasma sheet at higher density within that space relative to its density
in the space between the plasma sheet and the exit port of the chamber that lies on the optical axis.

US Pat. No. 9,578,729

EXTREME ULTRAVIOLET SOURCE WITH DUAL MAGNETIC CUSP PARTICLE CATCHERS

PLEX LLC, Fall River, MA...

1. An extreme ultraviolet light source comprising: a chamber; a source of droplet targets; one or more lasers focused onto
the droplets in an interaction region; a flowing buffer gas; one or more reflective collector elements to redirect extreme
ultraviolet light to a point on the collector optical axis which is an exit port of the chamber; a pair of similar polarity
field coils that generate a parallel magnetic field through the interaction region with magnetic symmetry axis perpendicular
to the optical axis; a pair of opposed field coils outside of the first pair that generate cusps with magnetic null points
on the magnetic axis; a pair of cylindrical beam dumps coaxial with the magnetic axis that intercept the radial outflow from
the cusps, wherein waste heat and exhaust particles are able to escape from magnetic confinement at the cusp waists and are
intercepted by the beam dumps.

US Pat. No. 10,040,792

SYNTHESIS OF A COMPOUND THAT MODULATES KINASES

Plexxikon Inc., Berkeley...

1. A process for preparation of a compound of formula I:
or a salt thereof, comprising:
contacting a compound of formula IV:

or a salt thereof, with a compound of formula V:

or a salt thereof, under reductive amination conditions to provide the compound of formula I or a salt thereof.

US Pat. No. 9,325,604

SYSTEM AND METHOD FOR DATA CENTER OPTICAL CONNECTION

PLEXXI INC., Nashua, NH ...

1. A fiber shuffle device configured to implement connectivity for a chordal ring network, the fiber shuffle device comprising:
a housing that includes a connector panel;
a plurality of optical connectors mounted to the connector panel, each optical connector being operative to receive an optical
cable connection,

the plurality of optical connectors comprising optical connectors being identified with an optical node group and optical
connectors being identified with an expansion group,

each of the optical connectors in the optical node group and the expansion group being associated with a first or a second
topology direction;

a first plurality of optical fibers, each fiber of the first plurality of optical fibers coupling an optical connector in
the optical node group to an optical connector in the expansion group such that at least some of the optical connectors in
the optical node group that are associated with the first topology direction are coupled via optical fibers to optical connectors
in the expansion group that are associated with the second topology direction; and

a second plurality of optical fibers, each fiber of the second plurality of optical fibers coupling an optical connector in
the optical node group to another optical connector in the optical node group such that at least some of the optical connectors
in the optical node group that are associated with the first topology direction are coupled via optical fibers to optical
connectors in the optical node group that are associated with the second topology direction,

wherein the first plurality of optical fibers and the second plurality of optical fibers are internal connections within the
housing.

US Pat. No. 10,123,998

KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method of treating a c-fms or c-kit mediated disease or condition in a subject in need thereof, comprising administering to the subject an effective amount of a compound of formula:or a pharmaceutically acceptable salt thereof, wherein said disease or condition is neurofibromatosis-1 (NF1), cutaneous neurofibromas or plexiform neurofibromas.

US Pat. No. 9,397,747

METHOD AND APPARATUS FOR CONNECTIVITY CONTROL IN A DATA CENTER NETWORK

PLEXXI INC., Nashua, NH ...

1. A computer-implemented method of maintaining connectivity of nodes in a network, the method comprising:
receiving, at a first node in the network, a first message directed in a first direction along a supervisor channel from a
source node, the first message comprising an ordered list of active nodes and a first field;

determining, at the first node, if the first field is set to a first value or a second value;
if the first field is set to the first value then forwarding the first message from the first node in the first direction
along the supervisor channel;

if the first field is set to the second value then:
determining, at the first node, whether the source node immediately precedes the first node in the ordered list of active
nodes and if so, forwarding the first message from the first node in the first direction along the supervisor channel, otherwise:

sending, from the first node, an update message in a second direction, opposite the first direction, along the supervisor
channel to the source node;

modifying, at the first node, the first message by changing the first field to the first value and forwarding, from the first
node, the modified first message in the first direction along the supervisor channel,

wherein the update message indicates that the ordered list of active nodes is incorrect.

US Pat. No. 9,994,567

SYNTHESIS OF HETEROCYCLIC COMPOUNDS

Plexxikon Inc., Berkeley...

1. A method for preparing a compound of formula (I):
or a pharmaceutically acceptable salt, a solvate or a tautomer thereof, said method comprising:
contacting a compound of formula (Ia):
with L2-P1 under conditions sufficient to form the compound of formula (I), wherein:Q is F or H;
P2 is —C(O)—R3 or —C(O)—OR4;
P1 is

R1 is H or halogen;
n is 0, 1 or 2;
m is 1 or 2;
R3 is C1-6alkyl, aryl, heteroaryl, aryl-C1-2alkyl, heteroaryl-C1-2alkyl, C3-10cycloalkyl, C3-10cycloalkyl-C1-2alkyl, ethynyl or vinyl, each of which is optionally substituted with 1-3 Ra groups;
R4 is C1-6alkyl, aryl, heteroaryl, aryl-C1-2alkyl, heteroaryl-C1-2alkyl, C3-10cycloalkyl, C3-10cycloalkyl-C1-2alkyl, ethynyl or vinyl, each of which is optionally substituted with 1-3 Ra groups;
L2 is Br, Cl, I, tosyl-O—, mesyl-O—, trifluoromethanesulfonyl-O—, —C(O)—O—CF3 or —C(O)—O—CH3; and
each Ra group is independently halogen, C1-6alkyl, fluoro substituted C1-6alkyl, fluoro substituted C1-6alkoxy, aryl, heteroaryl, C1-6alkoxy, —CN, —NO2, —OH, —C(O)—O—C1-6alkyl, or —SiMe3, wherein the aliphatic or aromatic portion of Ra is further optionally substituted with from 1-3 Rb groups, wherein each Rb group is independently halogen, C1-6alkyl, C1-6alkoxy, —CN, —NO2 or —OH.

US Pat. No. 9,938,273

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound having Formula I:
or a pharmaceutically acceptable salt or a solvate thereof, wherein:
Z2 is alkynyl optionally substituted with Rb, aryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, or heteroaryl, wherein each aryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, or heteroaryl is optionally substituted with 1-3 R1 groups;
Z3 is hydrogen or halo;
Z5 is -Cy-L;
Cy is heterocycloalkylene, arylene, or heteroarylene, wherein Cy is optionally substituted with 1-2 Ra groups;
L is:
—C(O)NR3R4, wherein:
R3 is hydrogen or C1-6alkyl optionally substituted with 1-3 G groups, and
R4 is alkoxy, hydroxyalkylene, cyano, cyanoalkylene, or aminocarbonylalkyl, wherein R4 is optionally substituted with 1-3 G groups;
or R3 and R4, together with the N atom to which they are attached, join to form a heterocycloalkyl or heteroaryl moiety, wherein 1-2 carbon atoms of the heterocycloalkyl or heteroaryl moiety is substituted with 1-2 G groups; or
—C1-3alkyl-heterocycloalkyl, —C(O)-heterocycloalkyl, —N(H)-heterocycloalkyl, —C(O)-cycloalkyl, or —O-heterocycloalkyl, each of which is optionally substituted with 1-3 G groups; or
—C(O)—N(H)—O—R5 or —NH—C(O)—Rc, wherein:
R5 is hydrogen, C1-6alkyl, or cycloalkyl; and
Rc is C1-6alkyl, cycloalkyl, or heterocycloalkyl; or
—SO2—NR6R7, —N(H)C(O)NR6R7, or —N(H)—SO2—NR6R7, wherein:
R6 is hydrogen, C1-6alkyl, alkylcarbonyl, alkylsulfonyl, cycloalkylamino, or cycloalkyl, wherein each of the C1-6alkyl, alkylcarbonyl, alkylsulfonyl, cycloalkylamino, and cycloalkyl are optionally substituted with 1-3 G groups,
R7 is hydrogen or C1-6alkyl optionally substituted with 1-3 G groups;
or R6 and R7, together with the N atom to which they are attached, join to form a heterocycloalkyl or heteoraryl moiety, wherein 1-2 carbon atoms of the heterocycloalkyl or heteroaryl moiety is substituted with 1-2 G groups; or
heterocycloalkyl substituted with 1-3 G groups;
R1 is hydrogen, C1-6alkyl, cycloalkyl, —C(O)-cycloalkyl, —C(O)alkyl, cyano, cyanoalkyl, cyanocycloalkyl, cyanocycloalkylalkyl, hydroxy, alkoxy, alkoxyalkyl, hydroxyalkyl, halo, haloalkyl, oxo, aryl, arylalkyl, cycloalkylsulfonyl, alkylsulfonyl, alkylsulfonylalkyl, alkylcarbonylaminoalkyl, alkylsulfonylaminoalkyl, heterocycloalkyl optionally substituted with 1-2 Ra, heterocycloalkylalkyl, —NR6R7, —C1-6alkylene-NR6R7, —C(O)O-alkyl, heterocycloalkyl optionally substituted with 1-2 Rd groups, or heteroaryl optionally substituted with 1-2 Re groups;
each G is independently C1-6alkyl, C1-6haloalkyl, halo, amino, alkylamino, dialkylamino, alkylaminoalkyl, —(C1-6alkylene)-amino, —CN, —C(O)—C1-6alkyl, —C(O)—O—C1-6alkyl, —CO2H, —C(O)—N(H)—C1-6alkyl, oxo, —N(H)—C(O)—C1-6alkyl, —C(?NH)—NH2, —OH, —N(H)—C(O)—O— C1-6alkyl, —N(H)—C(O)—N(H)—C1-6alkyl, —N(H)—S(O)2—C1-6alkyl, —S(O)2—C1-6alkyl, hydroxyalkyl, cycloalkyl, cycloalkylamino, alkoxy, heterocycloalkyl, or heteroaryl,
each Ra is independently alkyl, oxo, halo, or hydroxy;
Rb is halo, C3-6cycloalkyl, aryl, heteroaryl, —NR6R7, or hydroxy;
each Rd is independently C1-6alkyl, halo, oxo, alkylaminosulfonyl, alkylsulfonyl, alkylcarbonyl, hydroxyalkyl, or hydroxy; and
each Re is independently C1-6alkyl, halo, or hydroxy;
provided that when G is cycloalkyl, Z2 is alkynyl optionally substituted with C3-C6cycloalkyl, —NR6R7, or hydroxy;
and further provided that the compound is not

US Pat. No. 9,975,894

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
X, when present, is halo.

US Pat. No. 10,160,755

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound of Formula I(b) or I(c):
or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein:
R1 is

R2 is:

each R4 is independently H, C1-C3 alkoxy, C1-C4 alkyl, halo, hydroxy, cyano, cyclopropyl, 5-6 membered heterocycloalkyl, C(O)(R7), pyrrolidinylsulfonyl, amino, dimethylamino, isopropylsulfonamide, n-propyl sulfonamide, ethylsulfonamide, methylsulfonamide, N-methylmethanesulfonamide, cyclopropylsulfonamide, cyclopropylcarbonyl, —N(H)—C(O)-methyl, cyclopropylaminocarbonyl, carboxyl-(C1-C4)alkyl, oxenatyl, or 3-methyloxenatyl, wherein each alkyl, alkoxy, cyclopropyl, or heterocycloalkyl moiety of R4 is optionally substituted with 1-3 groups independently selected from C1-C4 alkyl, methoxy, fluoro and chloro;
each R7 is independently H, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, alkyl, alkoxy, hydroxyalkyl, amino, hydroxy, arylalkyl, heteroarylalkyl, or alkylsulfonyl;
and
L is absent, ethynylene, —O-alkylene-, —N(H)—C(O)—, —C(O)—N(H)—, or —N(H)—S(O)2—.

US Pat. No. 10,160,747

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound having Formula II(a) or II(b):
or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein:
Ring A is phenyl, pyridyl, pyrimidinyl, or pyridazinyl;
Y is N or CR9; R9 is hydrogen, halo, amino, alkyl optionally substituted with alkoxy or hydroxy, haloalkyl, or alkoxy;
(i) is a single bond, wherein:
Z1 is CH or N, Z2 is C(R12)(R12a) and Z3 is C(R13)(R13a); or
Z1 is CH, Z2 is N(R12) and Z3 is C(R13)(R13a); or
Z1 is CH, Z2 is C(R12)(R12a) and Z3 is N(R13);
or
(ii) is a double bond, wherein:
Z1 is CH or N, Z2 is C(R12) and Z3 is C(R13); or
Z1 is CH, Z2 is N and Z3 is C(R13); or
Z1 is CH, Z2 is C(R12) and Z3 is N;
R2 is

wherein:
Ring B is a 5 or 6-membered saturated or unsaturated ring having 0-3 heteroatoms selected from O, N, and S;
each Q is independently hydrogen, alkyl, halo, cyano, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, oxo, —R20OR21, —R20OR21, —R20OC(O)R21, —R20C(O)N(R24)(R25), —R20S(O)tR22, —R20N(R24)(R25), or —R20N(R24)(R25), or —R20N(R24)C(O)R21, wherein each alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl is independently optionally substituted with 1 to 3 groups each independently halo, oxo, amino, alkyl, haloalkyl or —R20OR21,
Q1 is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, —R23OR21, —R23OR23OR21, —R23C(O)R21, —R23N(R24)(R25), —R23OC(O)R21, —R23C(O)OR21, —R23C(O)N(R24)(R25), or —R23S(O)tR22 , wherein each alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl is independently optionally substituted with 1 to 3 groups each independently halo, oxo, amino, alkyl, haloalkyl or —R20OR21;
each Q3 is independently hydrogen, cyano, —S —C1-C2 alkyl, halo, C2-C3 alkenyl, C2-C3 alkynyl, C1-C3 alkoxy, cyclopropyl, amino, —N(H)(C1-C3alkyl), —N(H)C(O)C(H)=CH2 or C1-C3 alkyl, wherein each Q3 is optionally substituted with 1-3 substituents each independently halo, hydroxy or methoxy;
Q4 is hydrogen, cyclopropyl, C1 -C4 alkoxy, or C1-C4 alkyl optionally substituted with 1-3 substituents each independently halo, hydroxy or methoxy;
each R20 is independently alkylene, alkenylene, alkynylene or a direct bond;
each R21 is independently hydrogen, alkyl, haloalkyl, alkenyl, alkynyl or cycloalkyl;
each R22 is independently alkyl, haloalkyl, alkenyl, alkynyl or cycloalkyl;
each R23 is independently alkylene, alkenylene or alkynylene;
R24 and R25 are each independently hydrogen or alkyl;
a is an integer from 0 to 3;
each t is independently 0, 1 or 2;
R3 is hydrogen or C1-C6 alkyl;
each R6 is independently hydrogen, halo, C1-C3alkyl, or C1-C3 alkoxy;
each R7 is independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6alkoxy, C3-C6 cycloalkyl, 4-6 membered heterocycloalkyl, C3-C6cycloalkylalkyl, —S(O)2alkyl, or a 4-6 membered heterocycloalkyl-C1-C6 alkyl, wherein each R7 is optionally substituted with 1 to 3 groups each independently hydroxy, halo, C1-C6 alkyl, cyano or C1-C6 haloalkyl;
R9a is hydrogen, halo, hydroxy-C1-C6 alkyl, C1-C6 alkyl, or C1-C6 alkoxy-C1-C6 alkyl;
each R11 is independently a 5-6 membered heterocycloalkyl, cyano, C1-C6 alkoxy, C1-C6alkyl, C1-C6 haloalkyl, —C(O)OCH3, or —C(O)OH;
R10 is C1-C6 alkyl, hydroxy-C1-C6 alkyl, C1-C6alkoxy-C1-C6 alkyl, 5-membered heteroaryl optionally substituted with alkyl, C3-C6 cycloalkyl, —C(O)OCH3, or —C(O)OH;
R12 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, —(CH2)0-2—N(R1b)2, halo, C3-C6 cycloalkyl, —C(O)—C3-C6cycloalkyl, phenyl optionally substituted with 1-2 R11 groups, 5-6 membered heteroaryl optionally substituted with 1-2 R11 groups, or alkynyl optionally substituted with R10;
R13 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, —C(O)—C1-C4 alkyl, halo, cyano, —(CH2)0-2—N(R1b)2, —C(O)NHCH3, amino, —NHC(O)CF3, C3-C6 cycloalkyl, —C(O)—C3-C6 cycloalkyl, phenyl optionally substituted with 1-2 R11 groups, 5-6 membered heteroaryl optionally substituted with 1-2 R11 groups, or alkynyl optionally substituted with R10;
each R1b is independently hydrogen or alkyl;
R12a is hydrogen; or
R12 and R12a, together with the carbon to which they are attached, join to form a C3-6 spirocycloalkyl; or
R12 and R12a form an oxo group;
R13a is hydrogen; or
R13 and R13a, together with the carbon to which they are attached, join to form a C3-6 spirocycloalkyl; or
R13 and R13a form an oxo group; and
m is 0, 1 or 2.
US Pat. No. 9,095,594

PHARMACEUTICAL COMPOSITIONS COMPRISING BETA-LACTAM ANTIBIOTIC, SULBACTAM AND BETA-LACTAMASE INHIBITOR

Wockhardt Ltd., Bandra-K...

1. A pharmaceutical composition comprising pharmaceutically effective amount of: (a) at least one beta-lactam antibiotic or
a pharmaceutically acceptable salt thereof, (b) sulbactam or a pharmaceutically acceptable salt thereof, and (c) trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo-[3.2.1]-octane-2-carboxamide
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,114,711

FAULT DETECTION AND CORRECTION FOR SINGLE AND MULTIPLE MEDIA PLAYERS CONNECTED TO ELECTRONIC DISPLAYS, AND RELATED DEVICES, METHODS AND SYSTEMS

CINEPLEX DIGITAL MEDIA IN...

1. A method comprising:duplicating data associated with each of a plurality of media players to a back-up media player,
each of the plurality of media players being configured to output a signal to one or more of a plurality of electronic displays, each of the electronic displays configured to switch source inputs between a corresponding media player and a video splitter, the back-up media player configured to drive the duplicated data associated with each of the plurality of media players via the video splitter;
determining whether a fault exists in any of the plurality of media players that affects a corresponding electronic display;
switching the source input of the corresponding electronic display to the back-up media player via the video splitter; and
playing, on the corresponding electronic display, the duplicated data from the video splitter for any of the plurality of media players for which the fault exists.

US Pat. No. 9,155,389

SYSTEM FOR CONTROLLING SEAT EFFECT FOR FACILITY OF SHOWING PICTURES

CJ 4D PLEX CO., LTD., Se...

1. A system configured to provide an effect synchronized with a picture in a facility of showing pictures, comprising:
a first controlling device of a seat configured to transmit control information including an effect type or an effect strength
inputted from a user;

a second effect controlling device positioned at a front space of the seat configured to provide the effect synchronized with
the picture to a space in the seat; and

a central control device configured to relay the control information received from the first controlling device to the second
controlling device,

wherein the central control device configured to verify a mapping between the first controlling device and the second controlling
device for relaying the control information; and

the second controlling device provides the seat effect in accordance with the control information relayed through the central
control device.

US Pat. No. 9,337,931

CONTROL AND PROVISIONING IN A DATA CENTER NETWORK WITH AT LEAST ONE CENTRAL CONTROLLER

Plexxi Inc., Nashua, NH ...

1. A controller for provisioning one or more forwarding topologies in a network having a plurality of nodes the controller
comprising: at least one memory storing program instructions; and at least one processor operative to execute the program
instructions to:
receive information pertaining to an affinity topology, the affinity topology specifying affinity link attributes that describe
policies and attributes for communications between a plurality of application components of the network along affinity links,
wherein an affinity link represents a logical link between at least two application components within the network;

compute one or more end-to-end forwarding topologies based at least in part on the affinity topology, each end-to-end forwarding
topology identifying one or more network segments for configuring interconnections between the plurality of nodes for forwarding
traffic through the network, wherein each end-to-end forwarding topology is defined by at least one candidate forwarding path,
and a forwarding path identifies at least one network segment for forwarding traffic through the network;

compute, for each path of the at least one candidate forwarding path in the one or more end-to-end forwarding topologies,
an associated cost based at least in part on whether the path satisfies affinity link attributes in the affinity topology,
and

provide the one or more end-to-end forwarding topologies to the plurality of nodes based at least in part on the associated
costs, for use by the plurality of nodes in selecting an end-to-end forwarding configuration for the network.

US Pat. No. 9,614,264

FILTER

MesaplexxPty Ltd, Queens...

1. A cavity filter, comprising:
first and second dielectric resonator structures comprising respective pieces of dielectric material, each piece of dielectric
material having a shape such that it can support at least one resonant mode for an electromagnetic signal having a given frequency,
wherein each dielectric resonator structure is substantially coated in a conductive material, wherein at least one of the
first and second dielectric resonator structures comprises an aperture in its respective conductive coating for receiving
an unfiltered signal, or for outputting a filtered signal, and wherein the first and second dielectric resonator structures
each comprises a coupling aperture in its respective conductive coating, the coupling apertures being in communication with
each other for passing electromagnetic energy between the first and second dielectric resonator structures; and a patch element
located in the coupling apertures, having a shape and size such that the patch element is non-resonant for the electromagnetic
signal having the given frequency, wherein the patch element increases power handling capability of the cavity filter relative
to without having the patch element and reduce sensitivity to variations in thicknesses of the conductive material, wherein
a gap between the patch element and an edge of the coupling apertures is sized to increase the power handling capability of
the cavity filter across a whole passband relative to without selecting the size, wherein the size of the gap is selected
such that an electric field in the gap as a result of a symmetric electric field pattern in the first and second dielectric
resonator structures is equal to an electric field in the gap as a result of an antisymmetric electric field pattern in the
first and second dielectric resonator structures.

US Pat. No. 10,189,833

SOLID FORMS OF A COMPOUND MODULATING KINASES

Plexxikon Inc., Berkeley...

1. A method for treating a subject suffering from a disease or condition mediated by a protein kinase selected from c-fms, c-kit, Flt3 or a combination thereof, or mediated by macrophages or microglia, comprising administering to the subject a therapeutically effective amount of a crystalline form of Compound I:characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 7.3, 23.3 and 28.2° 2? as determined on a diffractometer using Cu—K? radiation.

US Pat. No. 9,359,665

METHOD OF MANUFACTURING SWAGE MOUNT HAVING A MIXTURE OF CONDUCTIVE MATERIAL AND A COATING MATERIAL

INTRI-PLEX TECHNOLOGIES, ...

1. A method of manufacturing a swage mount for hard disk drives, the method comprising:
depositing a conductive material on a predetermined part of the swage mount;
depositing a coating material on the swage mount including the predetermined part; and
applying heat to the swage mount, forming a mixture of the conductive material and the coating material.

US Pat. No. 9,090,616

NITROGEN CONTAINING COMPOUNDS AND THEIR USE

Wockhardt Ltd., Bandra-K...

1. A pharmaceutical composition comprising: (a) at least one antibacterial agent or a pharmaceutically acceptable salt thereof,
and (b) a compound of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof; wherein M is a cation.

US Pat. No. 9,981,150

AERIAL FIRE SUPPRESSION SYSTEM

SIMPLEX MANUFACTURING CO....

1. A fire suppression apparatus for fighting fires from a helicopter, comprising:a tank assembly comprising
(a) a foam tank for housing a foam and configured for attachment to the helicopter,
(b) a water tank located downstream of the foam tank for housing water and configured for attachment to the helicopter, wherein the water tank is configured to receive a foam from the foam tank that when mixed with water in the water tank forms a liquid fire retardant in the water tank, and
(c) a tank assembly housing that encases the foam tank and the water tank;
a centrifugal pump with a radial outflow impeller mountable to the helicopter and driven by an electric motor, the pump including an air induction valve with an electrically variable valve opening disposed at and connected to a suction end of the pump so as to form an air inlet, wherein air and the fire retardant are drawn into the suction end and pressurized by the pump; and
a cannon assembly including an aimable boom mountable to the helicopter and connected to the pump by a conduit, the boom including a nozzle on a distal end of the boom from which the pressurized fire retardant and air is dispensed toward a target.

US Pat. No. 9,301,026

AFFINITY MODELING IN A DATA CENTER NETWORK

PLEXXI INC., Nashua, NH ...

1. A system for configuring a network, the network having network elements including a plurality of network nodes and host
computers communicably connected to corresponding ones of the network nodes, pairs of the plurality of network nodes being
interconnected by network links, the network having an associated network topology and a current network state, the system
comprising:
at least one memory storing program instructions; and
at least one processor operative to execute the program instructions to implement a modeling component, the modeling component
operative to:

obtain the network topology associated with the network, the network topology identifying at least the plurality of network
nodes and the network links;

obtain an affinity topology associated with the network, the affinity topology identifying a plurality of affinity elements
that represent application components, each application component being executable on at least one of the host computers,
the affinity topology specifying policies and attributes that describe communications between the application components;

create an affinity-network topology that represents a logical combination of the network topology and the affinity topology
by binding individual affinity elements to associated network nodes; and

compute a forwarding topology based at least in part on the affinity-network topology, the forwarding topology identifying
one or more of the network links for forwarding traffic through the network; and

a local controller associated with at least one of the network nodes, the local controller operative to configure the associated
at least one of the network nodes to deterministically arrive at a consistent end-to-end forwarding configuration for the
network as a function of the current network state based at least in part on the forwarding topology.

US Pat. No. 9,065,582

OPTICAL ARCHITECTURE AND CHANNEL PLAN EMPLOYING MULTI-FIBER CONFIGURATIONS FOR DATA CENTER NETWORK SWITCHING

PLEXXI INC., Nashua, NH ...

1. A system, comprising:
at least one optical node,
wherein the optical node includes:
at least one pair of optical ports including a first optical port and a second optical port, the first optical port including
a plurality of separate optical inputs arranged in a predetermined sequence and identified as inputs 1 to N, the second optical port including a plurality of separate optical outputs arranged in the predetermined sequence and
identified as outputs 1 to N;

a plurality of optical connections on each of the first optical port and the second optical port, the plurality of optical
connections including a first optical connection connected to input 1 of the first optical port, a second optical connection connected to output N of the second optical port, and a plurality
of optical connection paths connected between input 2 to input N of the first optical port and output 1 to output N?1 of the second optical port, respectively;

an electrical switch;
at least one optical transmitter operative to receive at least one first electrical signal from the electrical switch, and
to provide at least one first optical signal on a specified wavelength w corresponding to the at least one first electrical
signal;

a first optical multiplexer operative to receive the at least one first optical signal on the specified wavelength w from
the at least one optical transmitter, and to add the at least one first optical signal to a first selected one of the plurality
of optical connections connected to a specified output k of the second optical port, wherein 1?k?N;

a first optical de-multiplexer operative to drop at least one second optical signal on the specified wavelength w from a second
selected one of the plurality of optical connections connected to a specified input j of the first optical port, wherein 1?j?k;
and

at least one optical receiver operative to provide at least one second electrical signal corresponding to the at least one
second optical signal to the electrical switch.

US Pat. No. 9,288,555

DATA CENTER NETWORK ARCHITECTURE

PLEXXI INC., Nashua, NH ...

1. A data center network, comprising:
a plurality of nodes interconnected with one another by one or more network segments, wherein at least two of the nodes each
includes a respective local controller;

a modeling component including at least one processor configured to execute at least one program out of at least one memory
to model an affinity-network topology, the affinity-network topology representing a logical combination of a network topology
associated with the network and an affinity topology specifying policies and attributes that describe communications between
a plurality of application components,

a first central controller, communicably coupled to each local controller, configured to provide a plurality of end-to-end
forwarding topologies with accompanying constraints to each local controller, each end-to-end forwarding topology being based
at least in part on the affinity-network topology and identifying one or more network segments for forwarding traffic through
the network and the accompanying constraints defining one or more datagrams to which the corresponding forwarding topology
applies; and

wherein each local controller is configured to, independently of all other local controllers, deterministically apply or remove
one or more of the forwarding topologies, to or from, hardware or software components of the associated node as a function
of a current network state to deterministically arrive at a consistent end-to-end forwarding configuration for the network,
and

wherein each local controller is further configured to, independently:
deterministically select and utilize at least one of the end-to-end forwarding topologies as an initial forwarding topology,
wherein the non-selected end-to-end forwarding topologies are maintained as alternative forwarding topologies, and

in response to a change in the current network state, deselect the initial forwarding topology independently and deterministically
select and utilize at least one of the alternative forwarding topologies in place of the initial forwarding topology, and

wherein each local controller selects the same alternative forwarding topology.

US Pat. No. 9,204,207

HIERARCHY OF CONTROL IN A DATA CENTER NETWORK

PLEXXI INC., Nashua, NH ...

1. A network node for forwarding traffic through a network interconnecting one or more other nodes by one or more network
segments, the network node comprising:
a local controller configured to receive a plurality of end-to-end forwarding topologies with accompanying constraints, each
end-to-end forwarding topology identifying one or more network segments for forwarding the traffic through the network and
the accompanying constraints defining one or more datagrams to which the corresponding forwarding topology applies, the local
controller being configured to deterministically apply or remove the forwarding topologies, to or from, hardware or software
components of the associated node based on an availability of the network segments to deterministically arrive at a consistent
end-to-end forwarding configuration for the network as a function of a current network state representing an operational status
of all of the network segments in the network; and

a switch configured to forward the traffic through the network in accordance with the consistent end-to-end forwarding configuration,
the switch including at least one of:

a packet switch,
a circuit switch, and
an optical switch,
wherein the local controller is further configured to receive and store the end-to-end forwarding topologies from a central
controller using a transaction-based commit model, and to accept or reject the same end-to-end forwarding topologies as the
end-to-end forwarding topologies accepted or rejected by each of the other local controllers using the transaction-based commit
model.

US Pat. No. 9,340,350

METHOD AND APPARATUS FOR FORMING A NOTCHED HINGE CONNECTION IN A THERMOFORMED CONTAINER

Tekni-Plex, Inc., Wayne,...

1. A plastic thermoformed container comprising:
a thermoformed sheet comprising a lid and a base formed in a mold from a thermoformable plastic material;
the thermoformed sheet including a notched hinge connection between adjoining edges of the base and lid for pivoting of the
base and lid between open and closed positions;

the notched hinge connection between the lid and base comprising:
a hinge line aligned along a hinge axis;
abutting planar wall portions of the lid and base adjacent either side of the hinge line having upper planar wall surfaces
lying in a common plane while the lid and base are in the open position, wherein the upper planar wall surfaces are in mating
planar engagement when the lid and base are in the closed position;

a plurality of thermoformed connecting membranes formed in notched areas of the mold surface, and extending generally transverse
to the hinge axis, the connecting membranes being recessed from the common plane and extending outwardly from lower surfaces
of the abutting wall portions on an outer side of the hinge connection, away from a direction of folding of the lid and base,
so as not to interfere with hinge closing; and

the connecting membranes being spaced apart along the hinge axis between fully severed portions of the abutting wall portions,
wherein the connecting membranes are strong enough to withstand multiple openings of the lid and base during use.

US Pat. No. 10,227,357

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound of formula:
or a pharmaceutically acceptable salt, a solvate, a tautomer or a deuterated analog thereof, wherein:
R17 and R18 are each independently C1-4 alkyl;
L is a bond, NHSO2—, —SO2NH—, —NHC(O)—, —C(O)NH—, —SO2—, —C(O)O—, —NHC(O)NH— or —C(?NH)NH—;
Z is aryl, aryl-C1-4alkyl, heteroaryl, heteroaryl-C1-4 alkyl, heterocycloalkyl, C3-6cycloalkyl, cycloalkyl-C1-4alkyl, or heterocyclyl-C1-4alkyl, wherein the aliphatic or aromatic portion of Z is each independently optionally substituted with from 1-3 Rd groups, wherein each Rd is independently selected from C1-6alkyl, C1-6 haloalkyl, C1-6alkoxy, C1-6 haloalkoxy, heteroaryl, halogen, —CN, —NH2, —NO2, —N(H)C1-6alkyl or —N(C1-6alkyl)2,
wherein each Rd group is optionally further substituted with C1-6alkyl;
R1 is C3-6 cycloalkyl, C3-6 cycloalkyl-C1-4alkyl, aryl, aryl-C1-4alkyl, heteroaryl, heteroaryl-C1-4 alkyl, heterocyclyl, heterocyclyl-C1-4alkyl, —C(O)—Rg, —C(O)NHRg, wherein R1 is optionally substituted with from 1-4 R3 members, wherein
each R3 is independently selected from halogen, —CN, C1-6alkyl, C1-6alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C3-6cycloalkyl, C3-6 cycloalkyl-C1-4alkyl, aryl, aryl-C1-4alkyl, heteroaryl, heteroaryl-C1-4 alkyl, heterocycloalkyl, heterocycloalkyl-C1-4alkyl, —NHRi, NRiRi, —NHC(O)Ri, —C(O)NH2, —C(O)NHRi, —C(O)NRiRi-, —NHS(O)2Ri, p-CH3C6H4SO2NH—, NH2SO2—, —SO2NHRi, —S(O)2NRiRi, —C(O)Ri, or —C(O)ORi-;
each Rg is independently aryl, aryl-C1-2alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, heterocycloalkyl or heterocycloalkyl-C1-4alkyl; and
each Ri is independently C1-6alkyl, C3-6cycloalkyl, heterocycloalkyl or heterocycloalkyl-C1-4alkyl.

US Pat. No. 9,401,537

MULTI-MODE FILTER

Mesaplexx Pty Ltd., Quee...

1. A multi-mode dielectric filter comprising:
a dielectric body having at least first and second orthogonal resonant modes;
a first coupling element formed on a first face of the dielectric body for coupling energy to at least a first resonant mode,
said first face having a lengthwise direction and a widthwise direction; and

a second coupling element formed on the first face of the dielectric body for coupling energy from at least the first resonant
mode;

wherein said dielectric body is continuously covered on all sides, except for said first face, with a layer of conductive
material, said first coupling element and said second coupling element being electrically connected to said layer of conductive
material at a first point and a second point, respectively, and extending on said first face in both said lengthwise direction
and said widthwise direction to a first end and a second end, respectively, said first coupling element having a first orientation
on said first face and said second coupling element having a second orientation on said first face;

so that the dielectric body supports a first coupling path between the first coupling element and the second coupling element
via the first resonant mode; and

so that the dielectric body supports a second coupling path between the first coupling element and the second coupling element
via the second resonant mode, the second coupling path being such that at least partial cancellation of at least some coupled
energy takes place so as to form at least one zero in a response of the filter,

wherein relative positions of said first point and said second point, and of said first end and said second end, and the relative
orientations of said first coupling element and said second coupling element to one another determine relative phases and
strengths of the first and second coupling paths, thereby enabling zeros in a response of the multi-mode dielectric filter
to be obtained at desired locations relative to poles in the response.

US Pat. No. 9,388,656

SUBSEA WELLHEAD INCLUDING MONITORING APPARATUS

Plexus Holdings, PLC., A...

1. A securement arrangement for securing a hanger within a subsea wellhead comprising monitoring means for monitoring an annular
space located below the hanger, the hanger comprising an inner casing secured at a lower end thereof, the annular space being
located between an outer surface of the inner casing and an inner surface of an outer casing, the monitoring means comprising
a sleeve securable within the wellhead, wherein the hanger comprises an outer sealing surface which extends around the complete
periphery thereof and, in which, the securement arrangement comprises a clamping arrangement which is arranged, in use, to
distort the sleeve inwardly to create a seal between the outer sealing surface of the hanger and an inner surface of the sleeve,
wherein the sleeve includes a monitoring fluid passageway which fluidly connects the annular space to a monitoring aperture
located above the hanger.

US Pat. No. 9,340,343

EGG CARTON WITH MATING CELL AND LID POST STRUCTURE

Tekni-Plex, Inc., Wayne,...

1. A plastic egg carton comprising:
a tray and a lid hingedly connected to the tray for pivoting between open and closed positions, the tray and the lid having
respective peripheral edges that mate with each other in the closed position, the egg carton having in the closed position
a length, a width and a height;

the tray having a plurality of cells for receiving individual eggs, the cells being arranged successively adjacent each other
along the length and width of the carton;

each cell having a bottom and a flexible outwardly curved sidewall extending upwardly from the bottom to form a corresponding
one of the cells;

the tray having a plurality of cell posts extending upwardly toward the lid above the peripheral edge of the tray, each cell
post having a central axis aligned with the height of the carton and being formed at an intersection of four adjacent cells
as an extension of the sidewalls of the four adjacent cells;

each cell post having four generally planar ramp surfaces, one disposed respectively on each of the four sidewall extensions
between the outwardly curved sidewalls of two adjacent cells, the planar ramp surfaces being aligned at an angle of from about
20 to about 45 degrees relative to the central axis of the cell post; and,

the lid having a plurality of lid posts, wherein the cell posts and the lid posts are configured to hold each egg axially
aligned with the central axis, each lid post extending downwardly toward the tray and including complementary planar ramp
surfaces for mating with the planar ramp surfaces of the cell post when the lid is in the closed position and wherein each
lid post includes four downwardly extending fingers, each finger having one of the complementary planar ramp surfaces.

US Pat. No. 9,169,058

TRI-FOLD EGG CARTON WITH LID SIDEWALL PROTRUSIONS

Tekni-Plex, Inc., Wayne,...

25. A tri-fold plastic egg carton for accommodating jumbo eggs, in both oriented and non-oriented positions, in individual
cell pockets comprising:
a cell base, a cell cover and lid, wherein the egg carton can be assembled in a closed position having a length, a width and
a height with the cell cover closed over the cell base and the lid closed over the cell cover;

the cell base having opposing elongated edges aligned along the length of the carton;
the cell cover having a hinged connection to one of the elongated edges of the cell base for pivoting between open and closed
positions with respect to the cell base, the base and cover each having a complementary matrix of cells that together form
a matrix of cell pockets for holding individual eggs when the cover is closed over the base, each cell pocket having a largest
diameter portion transverse to the carton height to accommodate a jumbo egg in the cell pocket when the cell cover is closed
over the cell base;

the lid having a hinged connection to the other elongated edge of the base for pivoting between open and closed positions,
wherein when the cover and base are in the closed position the lid can be closed over the cover to form the assembled carton
in the closed position;

the lid having a top wall, depending front and rear sidewalls aligned along the length of the carton, and depending end walls
aligned along the width at opposite ends of the carton;

the lid having rounded corners between the lid sidewalls and end walls,
the base and cover having flat peripheral mating surfaces that engage in planar relation when the cover is closed over the
base,

the lid having a flat peripheral mating surface that lies over and engages in planar relation the flat peripheral mating surfaces
of the closed cover and base, and

wherein the lid corners between the front sidewall and the two end walls each have a lip tab extending from the flat peripheral
mating surface of the lip, each lip tab having a first wall that extends generally transverse to the flat peripheral mating
surface to restrain movement of the base with respect to the cover in the closed position, and a second wall that extends
from the first wall to form a finger tab for moving the lid to an open position away from the closed cover and base.

US Pat. No. 9,165,578

SWAGE MOUNT FOR HARD DISK DRIVES

INTRI-PLEX TECHNOLOGIES, ...

1. A swage mount for a hard disk drive, the swage mount comprising:
a planar flange body having four sides and a predetermined thickness, a hub surrounding an aperture in the flange body; and
a substantially ‘T’ shaped tip having a stem part and a cross-bar part, the stem part extending from a side of the flange
body substantially in the plane of the flange body, the tip part having a predetermined thickness greater than a predetermined
thickness of the flange body, the stem part of the tip tapering from a first width at a proximal end of the stem part extending
from a side of the flange body, to a second narrower width at a distal end of the stem part extending from the cross-bar part.

US Pat. No. 10,435,404

FORMULATIONS OF A COMPOUND MODULATING KINASES

Plexxikon Inc., Berkeley...

1. A composition comprising: 40% to 60% W/W of Compound I having the following structure:and wherein Compound I is a crystalline HCl salt characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 7.3, 23.3 and 28.2° 2? as determined on a diffractometer using Cu-K? radiation; 20% to 35% W/W of a poloxamer; 10% to 22% W/W of an excipient; 1% to 5% W/W of a disintegrant; and 0.5% to 3% W/W of a lubricant.

US Pat. No. 10,301,280

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method for treating a subject suffering from a disease or condition selected from Alzheimer's disease (AD), Parkinson's disease, melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, sarcoma, gastrointestinal carcinoma, liver cancer, biliary tract carcinoma, bile duct carcinoma, colorectal cancer, lung cancer, gallbladder cancer, breast cancer, pancreatic cancer, thyroid cancer, renal cancer, ovarian cancer, adrenocortical carcinoma, prostate cancer, lymphoma, neurofibromatosis, gastrointestinal stromal tumors, acute myeloid leukemia, myelodysplastic syndrome, leukemia, tumor angiogenesis, medullary thyroid cancer, carcinoid, small cell lung cancer, Kaposi's sarcoma, pheochromocytoma, cancer-related pain and mastocytosis, said method comprising administering to the subject in need thereof an effective amount of a compound having Formula (IV):
or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer, or a deuterated analog thereof, wherein:
ring A is a 5-membered fused heteroaryl ring having from 1-3 heteroatoms as ring members selected from O, N, or S;
each R7 is independently selected from C1-6alkyl, deuterated C1-6alkyl, C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, —X1-aryl, aryl-C1-4alkylene-X1—, heteroaryl-C1-4 alkylene-X1—, C3-6cycloalkyl-X1—, C3-6cycloalkyl-C1-4alkylene-X1—, C3-6cycloalkenyl-X1—, CH2?CH—X1, C3-6cycloalkyl-C2-4alkenylene-X1—, C3-6cycloalkyl-C2-4alkynylene-X1—, heterocyclyl-X1—, heterocyclyl-C1-4alkylene-X1— or R8, wherein R8 is selected from halogen, —CN, —OH, —NH2, —NO2, —C(O)OH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —ORa, —SRa, —OC(O)Ra, —OC(S)Ra, —C(O)Ra, —C(S)Ra, —C(S)ORa, —S(O)Ra, —S(O)2Ra, —C(O)NHRa, —C(S)NHRa, —C(O)NRaRa, —C(S)NRaRa, —S(O)2NHRa, —S(O)2NRaRa, —C(NH)NHRa, —C(NH)NRaRa, —NHC(O)Ra, —NHC(S)Ra, —NRaC(O)Ra, —NRaC(S)Ra, —NHS(O)2Ra, —NRaS(O)2Ra, —NHC(O)NHRa, —NHC(S)NHRa, —NRaC(O)NH2, —NRaC(S)NH2, —NRaC(O)NHRa, —NRaC(S)NHRa, —NHC(O)NRaRa, —NHC(S)NRaRa, —NRaC(O)NRaRa, —NRaC(S)NRaRa, —NHS(O)2NHRa, —NRaS(O)2NH2, —NRaS(O)2NHRa, —NHS(O)2NRaRa, —NRaS(O)2NRaRa, —NHRa, or —NRaRa, wherein each Ra is independently selected from C1-6alkyl, aryl, aryl-C1-2alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, heterocycloalkyl, or heterocycloalkyl-C1-4alkyl, wherein each Ra is further optionally substituted with 1-3 Rb substituents independently selected from C1-6alkyl, C1-6alkoxy, halogen, C1-6 haloalkyl, or C1-6 haloalkoxy; wherein X1 is a bond or —C(O)— and
wherein R7 is optionally substituted with from 1-5 R9 members selected from halogen, —CH?CH2, —CN, —OH, —NH2, —NO2, —C(O)OH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —ORc, —SRc, —OC(O)Rc, —OC(S)Rc, —P(?O)HRc, —P(?O)RcRc, —PH(?O)ORc, —P(?O)(ORc)2, —OP(?O)(ORc)2, —C(O)Rc, —C(S)Rc, —C(O)ORc, —C(S)ORc, —S(O)Rc, —S(O)2Rc, —C(O)NHRc, —C(S)NHRc, —C(O)NRcRc, —C(S)NRcRc, —S(O)2NHRc, —S(O)2NRcRc, —C(NH)NHRc, —C(NH)NRcRc, —NHC(O)Rc, —NHC(S)Rc, —NRcC(O)Rc, —NRcC(S)Rc, —NHS(O)2Rc, —NRcS(O)2Rc, —NHC(O)NHRc, —NHC(S)NHRc, —NRcC(O)NH2, —NRcC(S)NH2, —NRcC(O)NHRc, —NRcC(S)NHRc, —NHC(O)NRcRc, —NHC(S)NRcRc, —NRcC(O)NRcRc, —NRcC(S)NRcRc, —NHS(O)2NHRc, —NRcS(O)2NH2, —NRcS(O)2NHRc, —NHS(O)2NRcRc, —NRcS(O)2NRcRc, —NHRc, Rc, or —NRcRc; or two adjacent R9 substituents, together with the atoms to which they are attached, form a 5 or 6-membered ring having from 0-2 heteroatoms selected from O, N, or S;
wherein each Rc is independently selected from C1-6alkyl, aryl, aryl-C2alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, heterocycloalkyl, or heterocycloalkyl-C1-4alkyl, wherein each Rc is further optionally substituted with from 1-3 Rd groups independently selected from —CN, —OH, —N(Re)(Re), —NO2, —C(O)OH, —C(O)NH2, —S(O)2NH2, —NHC(O)NH2, —C(NH)NH2, —OC(O)Re, —OC(S)Re, —C(O)Re, —C(S)Re, —C(O)ORe, —P(?O)HRe, —P(?O)ReRe, —PH(?O)ORe, —P(?O)(ORe)2, —OP(?O)(ORe)2, —S(O)2Re, —C(O)NHRe, C1-6alkyl, C1-6alkoxy, halogen, C1-6 haloalkyl, or C1-6 haloalkoxy, wherein each Re is independently C1-6alkyl;
or two adjacent R7 substituents together with the atoms to which they are attached form a 4-, 5-, or 6-membered carbocyclic ring or heterocyclic ring having from 1-2 heteroatoms as ring members selected from O, N, or S;
Y2 is C—R10, wherein R10 is H, C1-6alkyl, C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, aryl-C1-4alkyl-, heteroaryl-C1-4 alkyl-, C3-6cycloalkyl-C1-4alkyl-, C3-6cycloalkenyl-C1-4alkyl-, CH2?CH—X2—, C3-6cycloalkyl-C2-4alkenylene-X2—, C3-6cycloalkyl-C2-4alkynylene-X2—, heterocyclyl-C1-4alkyl-, or R8, each of which is optionally substituted with from 1-5 R9 groups; wherein X2 is C1-4alkylene, —O—, —S—, or —NH—;
R3 and R4 are each independently selected from H, halogen, C1-6 alkyl, C1-4haloalkyl, C1-4haloalkoxy, cyclopropyl, phenyl, —CN, CN—CH2—, C1-6alkoxy, or Rg; or R3 and R4 are taken together with the atoms to which they are attached form an optionally substituted 4 to 8-membered ring having from 0-2 heteroatoms as ring members selected from O, N, or S;
wherein Rg is —OH, —NH2, —NO2, —C(O)OH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —ORh, —SRh, —OC(O)Rh, —OC(S)Rh, —C(O)Rh, —C(S)Rh, —C(O)ORh, —C(S)ORh, —S(O)Rh, —S(O)2Rh, —C(O)NHRh, —C(S)NHRh, —C(O)NRhRh, —C(S)NRhRh, —S(O)2NHRh, —S(O)2NRhRh, —C(NH)NHRh, —C(NH)NRhRh, —NHC(O)Rh, —NHC(S)Rh, —NRhC(O)Rh, —NRhC(S)Rh, —NHS(O)2Rh, —NRhS(O)2Rh, —NHC(O)NHRh, —NHC(S)NHRh, —NRhC(O)NH2, —NRhC(S)NH2, —NRhC(O)NHRh, —NRhC(S)NHRh, —NHC(O)NRhRh, —NHC(S)NRhRh, —NRhC(O)NRhRh, —NRhC(S)NRhRh, —NHS(O)2NHRh, —NRhS(O)2NH2, —NRhS(O)2NHRh, —NHS(O)2NRhRh, —NRhS(O)2NRhRh, —NHRh, or —NRhRh, wherein each Rh is independently H or Ca-2alkyl;
R5 is H or C1-4alkyl;
Y1 is N or C;
Y3 is CH; and
the subscript m is 0, 1, or 2.

US Pat. No. 9,539,757

PACKING TRAY HAVING CELL POCKETS WITH EXPANDABLE SIDEWALLS AND FLOATING BASE, AND METHOD OF MANUFACTURE

Tekni-Plex, Inc., Wayne,...

1. A packing tray for packaging pears and other pear shaped fruit, the packing tray comprising:
a plastic foam sheet comprising a top wall and an array of recessed cell pockets extending from the top wall;
the top wall having a peripheral surface surrounding the array of cell pockets and defining a top reference plane TRP;
each cell pocket comprising a pear shaped recess having an elongated longitudinal axis LA parallel to the TRP and configured
to be substantially aligned with a longitudinal axis of a pear or pear shaped fruit lying on its side in the recess, and a
transverse axis A;

the pear shaped recess including an upper tapered cell portion configured to receive an upper tapered portion of a pear and
a lower rounded cell portion configured to receive a larger diameter base of a pear lying on its side in the recess;

the tapered cell portion having a pair of opposing sidewalls that flare outwardly to join a rounded sidewall of the rounded
cell portion, and the tapered cell portion having a bottom surface inclined with respect to the TRP and joining the flaring
sidewall portions;

the rounded cell portion further including a bottom portion including a plurality of circumferential flutes surrounding a
central depression, the sidewall of the rounded cell portion including a plurality of linear flutes disposed substantially
transverse to the TRP;

wherein the sidewall flutes and circumferential flutes flex in response to the weight and dimensions of the fruit enabling
the depression to move both parallel to and laterally with respect to the transverse axis A to accommodate different dimensions
and weights of fruit disposed in each cell pocket.

US Pat. No. 9,273,532

SECUREMENT ARRANGEMENT FOR SECURING CASING INSIDE A SUBSEA WELLHEAD

Plexus Holdings, PLC., A...

1. A securement arrangement for securing a hanger within a subsea wellhead, comprising:
a hanger comprising:
an outer sealing surface;
a plurality of first longitudinal ribs located below the outer sealing surface and a plurality of second longitudinal ribs
located above the outer sealing surface, the outer radial extent of each of the first and second longitudinal ribs corresponds
to the radial extent of the outer sealing surface, and the first and second longitudinal ribs and the outer sealing surface
being in fixed positions relative to each other;

an abutment surface provided by the first longitudinal ribs;
a tubular member comprising an inner radial sealing surface and a retaining shoulder arranged to support the hanger in a first
position relative to the sleeve; and

a clamping arrangement arranged to secure the hanger in a second position relative to the sleeve and to form a seal between
the outer sealing surface of the hanger and the inner sealing surface of the tubular member;

wherein, in the first position the abutment surface is in contact with the retaining shoulder, the second longitudinal ribs
are in contact with the inner sealing surface, and a fluid passageway is provided through the first longitudinal ribs, over
the outer sealing surface and through the second longitudinal ribs, and

wherein, in the second position the first longitudinal ribs, second longitudinal ribs and the outer sealing surface are in
contact with the inner sealing surface such that fluid cannot flow around the outer sealing surface of the hanger.

US Pat. No. 9,149,966

FILM STRUCTURE WITH HIGH OXYGEN BARRIER PROPERTIES AND METHOD OF MANUFACTURING SUCH A FILM STRUCTURE

Tekni-Plex Europe, Naamlo...

1. A method for manufacturing a film structure, which method comprises co-extruding a multi-layered film structure comprising
at least five layers, including two outer layers (2) made of a polyolefin, on each of which is provided, on opposite sides a layer (4) forming a gas barrier, and wherein, between both gas barriers is provided a layer (3) made of a foamed synthetic material, the method including mixing base material for the two outer layers (2) of polyolefin with binder which makes it possible to bond the polyolefin layers (2) with the above-mentioned barrier layers (4).

US Pat. No. 10,421,761

COMPOUNDS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound of formula:or a pharmaceutically acceptable salt thereof, wherein:R1 and R2 are each independently selected from C1-6alkyl, C3-8cycloalkyl, C3-8cycloalkyl-C1-4alkyl, aryl, aryl-C1-4alkyl, heteroaryl and heteroaryl-C1-4alkyl, each of which is optionally substituted with 1, 2 or 3 Rh members selected from F, Cl, Br, I, —CN, —OH, —CF3, NH, CF3O—, CH3—, CH3O, —NO2, cyclopropyl, cyclopropylmethyl, cyclopropylamino, cyclopropylmethylamino, 1-cyanocyclopropyl, methylamino, dimethylamino, methylthio, acetoxy, acetyl, methoxycarbonyl, acetamido, methylcarbamoyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyridylmethyl, 3-pyridylmethyl, 4-pyridylmethyl, 2-oxetanyl, 3-oxtetanyl, 2-oxetanylmethyl, 3-oxtetanylmethyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrofuranylmethyl, 3-tetrahydrofuranylmethyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 2-tetrahydrothiophenyl, 3-tetrahydrothiophenyl, 4-morpholinyl, 2-morpholinyl and 3-morpholinyl; or
R1 and R2 taken together with the nitrogen to which they attach form an optionally substituted 5- or 6-membered heterocycloalkyl ring having from 0-1 additional heteroatoms as ring members selected from O, N and S;
R3 is H;
R4 is hydrogen, F, Cl, —CH3, —CN, or —CF3;
R16 is hydrogen, optionally substituted aryl or optionally substituted C1-6alkyl; and
R19 is hydrogen or 2-(methoxycarbonylamino)propyl.

US Pat. No. 9,494,955

METHOD FOR CONTROLLING A HEAT-GENERATING ELEMENT

Dimplex North America Lim...

1. A method of controlling a heat-generating element that generates heat when electric current is passed therethrough to control
an ambient temperature within a space in which a sensor for sensing temperatures is at least partially located, the method
comprising:
(a) sensing an initial temperature;
(b) permitting passage of the electric current through the heat-generating element at a preselected output for a preselected
initial time period;

(c) after the electric current has passed through the heat-generating element for the preselected initial time period, sensing
a second temperature;

(d) determining a first temperature difference between the initial temperature and the second temperature; and
(e) determining a maximum error between:
a sensed temperature sensed at a selected time after the initial time period, and
the ambient temperature at the selected time,
in accordance with a predetermined relationship between the first temperature difference and the maximum error.

US Pat. No. 10,508,085

COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A compound of Formula I(c):
or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein:
R4, R5 and R6 are each independently H, halogen, alkyl, haloalkyl, —OCH3 optionally substituted with 1-3 halogens, or C3-C6cycloalkyl optionally substituted with 1-3 halogens,
provided that at least one of R4, R5 or R6 is not H;
R7 is one of the following groups (a)-(f):
(a) cycloalkenyl optionally substituted with 1-7 Z1 and optionally substituted with 1 Z4;
(b) heterocycloalkyl substituted with 1-9 Z2 and optionally substituted with 1 Z5;
(c) a bridged heterocyclic ring optionally substituted with 1-5 Z2 and optionally substituted with 1 Z5;
(d) a spiro ring system containing two heterocycloalkyl groups joined by one common spiro carbon atom, wherein the spiro ring system is optionally substituted on its carbon atoms with 1-8 Z3, and wherein the spiro ring system is optionally N-substituted with alkyl, haloalkyl, —CO2-alkyl, —C(O)NR10R11, —SO2NR10R11, —SO2-alkyl, SO2-haloalkyl, or —SO2-cycloalkyl substituted with 1-6 halogens;

each Y is independently H, D, halogen, alkyl, or haloalkyl, or 2 Y groups join together with the carbon atom to which they are attached to form a cycloalkyl optionally substituted with 1-3 halogens;
R8 is H, —CH3, —CFH2, —CF2H or —CF3;
R8b is H, F, Cl, —CH3, —CFH2, —CF2H or —CF3;
R9 is —(CY2)0-3—R12;
or R8 and R9join together with the carbon atom to which they are attached to form one of the following groups (a)-(e):
(a) a cycloalkyl optionally substituted with 1-9 Z2 and optionally substituted with 1 Z5 or 1-2 Z6;
(b) a heterocycloalkyl optionally substituted with 1-9 Z2 and optionally substituted with 1 Z5;
(c) a spiro ring system containing two cycloalkyl groups joined by one common spiro carbon atom, wherein the spiro ring system is optionally substituted with 1-9 Z2 and optionally substituted with 1 Z5 or 1-2 Z6;
(d) a spiro ring system containing one cycloalkyl and one heterocycloalkyl joined by one common spiro carbon atom, wherein the spiro ring system is optionally substituted on its carbon atoms with 1-9 Z3, and wherein the spiro ring system is optionally N-substituted with alkyl, haloalkyl, —CO2-alkyl, —C(O)NR10R11, —SO2NR10R11, —SO2-alkyl, SO2-haloalkyl, or —SO2-cycloalkyl substituted with 1-6 halogens; or
(e) a spiro ring system containing one cycloalkyl and one a bridged ring joined by one common spiro carbon atom, wherein the spiro ring system is optionally substituted with 1-5 Z2 and optionally substituted with 1 Z5;
R10 is H, alkyl, or haloalkyl;
R11 is H, alkyl, haloalkyl, cyanoalkyl, CN, alkynyl, phenyl optionally substituted with 1-4 J3, heteroaryl optionally substituted with 1-4 J3, heterocycloalkyl optionally substituted with 1-4 J3, -alkylene-C(O)—OH, -alkylene-C(O)—NH2, -alkylene-C(O)—N(H)-alkyl, -alkylene-C(O)—N(alkyl)2, alkoxy, -alkylene-C(O)-phenyl optionally substituted with 1-4 J3, —C(O)—O-alkyl, alkylene-C(O)—O-alkyl, hydroxyalkyl, cycloalkyl optionally substituted with 1-4 J3, cycloalkylalkyl optionally substituted with 1-4 J3, -alkylene-phenyl optionally substituted with 1-4 J3, -alkylene-SO2-phenyl optionally substituted with 1-4 J3, -alkylene-SO2-alkyl, -alkylene-NH—SO2—C1-C6 alkyl, alkoxyalkyl, alkoxycarbonyl, alkylcycloalkyl optionally substituted with 1-4 J3, -alkylene-heterocycloalkyl optionally substituted with 1-4 J3, -alkylene-heteroaryl optionally substituted with 1-4 J3, or —C(O)— phenyl optionally substituted with 1-4 J3;
R12 is one of the following groups (a)-(g):
(a) a saturated cycloalkyl optionally substituted with 1-9 Z2 and optionally substituted with 1 Z5 or 1-2 Z6;
(b) an unsaturated cycloalkyl optionally substituted with 1-7 Z2 and optionally substituted with 1 Z5;
(c) a heterocycloalkyl optionally substituted 1-9 Z2 and optionally substituted with 1 Z5;
(d) phenyl optionally substituted with 1-2 Z2;
(e) a bridged ring optionally substituted with 1-5 Z2 and the bridged ring is optionally substituted on a carbon atom with —N(H)(SO)2-alkyl and the bridged ring is optionally N-substituted with alkyl, haloalkyl, —SO2-alkyl, —SO2-haloalkyl; —CO2-alkyl, —C(O)NR10R11, —SO2NR10R11, or —SO2-cycloalkyl substituted with 1-5 halogens;
(f) heteroaryl optionally substituted with 1-2 Z2; or
(g) alkyl optionally substituted with 1-2 G groups;
each G is independently —CF3, C3-6cycloalkyl, CN, NH2, N(H)alkyl, —N(H)C(O)-alkyl, or —N(C1-C6alkyl)2;
J1 is C1-C6alkyl optionally substituted with 1-4 J3, —C1-C6alkylene-C1-C6alkoxy, C1-C6cyanoalkyl, C1-C6hydroxyalkyl, C0-C3 alkylene-C3-C6 cycloalkyl optionally substituted with 1-4 J3, C0-C3 alkylene-phenyl optionally substituted with 1-4 J3, —C0-C3 alkylene-5-6 membered heteroaryl optionally substituted with 1-4 J3, —C0-C3 alkylene-4-6 membered heterocycloalkyl optionally substituted with 1-4 J3;
J2 is H, C1-C6alkyl, or C1-C6haloalkyl;
each J3 is independently halogen, C1-C6alkyl, C1-C6haloalkyl, OH, C1-C6alkoxy optionally substituted with 1-3 halogens, CN, —C0-C3 alkylene-4-6 membered heterocycloalkyl optionally substituted with C1-C3alkyl, —S(O)2—C1-C6alkyl, —NH2, —N(H)—C1-C6alkyl, or —N(C1-C6alkyl)2, provided that when J3 is attached to nitrogen, J3 cannot be halogen, OH, CN, NH2, —N(H)—C1-C6alkyl, or —N(C1-C6alkyl)2;
each Z1 is independently CN, halogen, alkyl, or haloalkyl;
each Z2 is independently —OH, CN, halogen, alkyl, cycloalkyl optionally substituted with 1-3 halogens, hydroxyalkyl, haloalkyl, —NH2, —N(H)alkyl, —N(alkyl)2, alkoxyl optionally substituted with halo or phenyl, 5-6 membered heterocycloalkyl, or 5-6 membered heteroaryl, provided that when Z2 is attached to nitrogen, Z2 cannot be —OH, CN, halogen, alkoxyl, —NH2, —N(H)alkyl, or —N(alkyl)2;
each Z3 is independently CN, halogen, alkyl or haloalkyl;
Z4 is alkoxyalkyl, phenyl optionally substituted with 1-3 halogens, —SO2-alkyl, —SO2-haloalkyl, —SO2-cycloalkyl optionally substituted with 1-6 halogens, —C(O)NR10R11, —SO2NR10R11, —N(H)SO2-alkyl, —N(H)SO2-cycloalkyl optionally substituted with 1-6 halogens, or —N(H)SO2-haloalkyl;
Z5 is alkoxyalkyl, —SO2-alkyl, —CO2-alkyl, —C(O)J1, CO2J2, —C0-C4alkylene-phenyl optionally substituted with 1-4 J3, —C0-C4alkylene-CH(phenyl)2 optionally substituted with 1-4 J3, —C0-C4alkylene-CH(C3-C6cycloalkyl)2 optionally substituted with 1-4 J3, —SO2-haloalkyl, —SO2-cycloalkyl optionally substituted with 1-6 J3, —SO2-heterocycloalkyl optionally substituted with 1-6 J3, —SO2-heteroaryl optionally substituted with 1-6 J3, —SO2-aryl optionally substituted with 1-6 J3, —C(O)NR10R11, —SO2NR10R11, —N(H)SO2-alkyl optionally substituted with 1-6 J3, —N(H)SO2-aryl optionally substituted with 1-6 J3, —N(H)SO2-cycloalkyl optionally substituted with 1-6 J3, —N(H)SO2-heterocyloalkyl optionally substituted with 1-6 J3, —N(H)SO2-heteroaryl optionally substituted with 1-6 J3, —N(H)SO2-haloalkyl, optionally substituted with 1-6 J3, —C(O)—N(H)SO2-alkyl optionally substituted with 1-6 J3, —C(O)—N(H)SO2-aryl optionally substituted with 1-6 J3, —C(O)—N(H)SO2-cycloalkyl optionally substituted with 1-6 J3, —C(O)—N(H)SO2-heterocyloalkyl optionally substituted with 1-6 J3, —C(O)N(H)SO2-heteroaryl optionally substituted with 1-6 J3, —C(O)N(H)SO2-haloalkyl, or —C(NW2)?N—T, provided that when Z5 is attached to nitrogen, Z5 cannot be —N(H)SO2-alkyl, —N(H)SO2-aryl, —N(H)SO2-cycloalkyl, —N(H)SO2-heterocyloalkyl, —N(H)SO2-heteroaryl, or —N(H)SO2-haloalkyl;
each W is independently H, alkyl or haloalkyl;
T is alkyl, haloalkyl, hydroxyalkyl, alkoxy or CN; and
each Z6 is independently halo, alkyl, haloalkyl, CN, OH, cycloalkyl, aryl or heteroaryl, provided that only one Z6 can be OH.

US Pat. No. 10,370,374

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A method for treating a subject with a disease or condition mediated by a bromodomain, said method comprising administering to the subject in need thereof:(1) an effective amount of a compound of formula (II):

or a pharmaceutically acceptable salt thereof, wherein R1 is (C1-C3)alkyl; and
(2) optionally one or more additional therapeutic agents;
wherein the disease or condition is lung cancer, breast cancer, colon cancer, midline carcinomas, acral lentiginous melanoma, acute eosinophilic leukemia, acute erythroid leukemia, acute lymphoblastic leukemia, acute megakaryoblastic leukemia, acute monocytic leukemia, acute promyelocytic leukemia, adenocarcinoma, adult T-cell leukemia/lymphoma, aggressive NK-cell leukemia, AIDS-related lymphoma, anaplastic large cell lymphoma, angioimmunoblastic T-cell lymphoma, B-cell chronic lymphocytic leukemia, B-cell prolymphocytic leukemia, B-cell lymphoma, bone cancer, Burkitt's lymphoma, cutaneous T-cell lymphoma, colorectal cancer, diffuse large B-cell lymphoma, enteropathy-associated T-cell lymphoma, follicular lymphoma, glioblastoma multiforme, glioma, gastric cancer, hepatosplenic T-cell lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, leukemia, lymphoma, acute lymphocytic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia, small cell lung cancer, non-small cell lung cancer, MALT lymphoma, malignant peripheral nerve sheath tumor, mantle cell lymphoma, marginal zone B-cell lymphoma, mast cell leukemia, medullary carcinoma of the breast, medulloblastoma, melanoma, merkel cell cancer, mesothelioma, multiple myeloma, neuroblastoma, neurofibroma, nodular melanoma, osteosarcoma, ovarian cancer, precursor T-lymphoblastic lymphoma, primary central nervous system lymphoma, primary effusion lymphoma, prostate cancer, pancreatic cancer, skin cancer, T-cell lymphoma, or uveal melanoma.

US Pat. No. 10,316,032

SOLID FORMS OF A COMPOUND FOR MODULATING KINASES

Plexxikon Inc., Berkeley...

1. A crystalline form of Compound I:which is Compound I Form B, characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 10.4, 16.0, and 18.0 °2? as determined on a diffractometer using Cu—K? radiation.

US Pat. No. 10,060,851

SURFACE PLASMON DETECTION APPARATUSES AND METHODS

PLEXENSE, INC., Yongin-S...

1. A method of making a polymeric layer on a polymeric substrate, the method comprising:providing a liquid composition comprising a binder polymer and a solvent, the binder polymer comprising amine terminals;
providing an article comprising a polymeric surface with one or more functional groups reactive with amine, wherein the polymeric surface does not comprise inorganic glass or crystalline material;
causing the liquid composition to contact the polymeric surface;
applying a gas phase plasma at atmospheric pressure for a period between 1 millisecond and 1 minute to the liquid composition contacting the polymeric surface such that the liquid composition is interposed between the gas phase plasma and the polymeric surface, which to form a polymeric layer comprising cross-linked binder polymers bonded to the polymeric surface by chemical reactions between amine terminals of the binder polymer and the one or more functional groups of the polymeric surface, wherein the gas phase plasma does not comprise ammonia,
wherein causing the liquid composition to contact the plasma surface comprises immersing the article into the liquid composition such that the polymeric surface is submerged under the liquid composition when applying the gas phase plasma, and
wherein applying the gas phase plasma comprises generating the gas phase plasma using a plasma generator having at least one electrode, wherein while applying the gas phase plasma, none of the at least one electrode of the plasma generator electrically contacts the liquid composition.

US Pat. No. 10,027,616

PROXIMITY DISCOVERY SYSTEM AND METHOD

PLEXUS MEET, INC., La Ha...

1. A proximity discovery system comprising:a server for storing contact data; and
a plurality of user devices comprising a first user device and a second user device;
each of the plurality of user devices comprising:
a) an antenna and transceiver for exchanging discovery messages with a plurality of mobile devices within approximately 100 meters of the user device;
b) a proximity detector for estimating a distance from the user device to each of the other plurality of mobile devices within approximately 100 meters of the user device;
c) a user detection module configured to:
i) generate discovery messages to each of the other plurality of mobile devices; and
ii) detect the discovery messages from each of the other plurality of mobile devices;
iii) wherein the discovery messages consist of a user name and digital photo;
d) a connection module configured, if at least one user requests a connection, to:
i) transmit a user profile to the at least one user requesting the connection; and
ii) receive a user profile from the at least one user requesting the connection;
iii) wherein a user profile comprises user biographic information and user professional information in which social media contact data are shared.

US Pat. No. 9,216,068

OPTICS FOR VIDEO CAMERAS ON A SURGICAL VISUALIZATION SYSTEM

CAMPLEX, INC., Germantow...

1. A medical apparatus comprising:
a surgical retractor;
at least one video camera comprising imaging optics and an optical sensor, said at least one camera disposed on said surgical
retractor; and

a stop forward said imaging optics,
wherein said imaging optics comprises wafer-scale optics,
wherein said sensor is proximal said imaging optics with said imaging optics between said stop and said sensor, and
wherein said stop is the most distal optical element of said camera.

US Pat. No. 9,132,133

NITROGEN CONTAINING COMPOUNDS

Wockhardt Ltd., Bandra-K...

1. A method for treating a bacterial infection in a subject, said method comprising administering to said subject a pharmaceutically
effective amount of: (a) at least one antibacterial agent or a pharmaceutically acceptable derivative thereof, and (b) a compound
of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof:

wherein:
R1 is:

(a) hydrogen,
(b) (CO)n—R3, or

(c) COOR4.

n is 0, 1 or 2;
R2 is:

(a) SO3M,

(b) SO2NH2,

(c) PO3M,

(d) CH2COOM,

(e) CF2COOM,

(f) CHFCOOM, or
(g) CF3;

M is hydrogen or a cation;
R3 is:

(a) hydrogen,
(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8, NR5CONR6R7, heterocyclyl, heteroaryl, cycloalkyl or aryl,

(c) CN,
(d) NR6R7,

(e) CON R6R7,

(f) NHCONR6R7,

(g) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(h) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(i) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(j) cycloalkyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(k) cycloalkyl substituted with C1-C6 alkyl wherein C1-C6 alkyl is further substituted with one or more substituents independently selected from OR5, NR6R7, halogen, CN, or CONR6R7, or

(I) OR8;

R4 is:

(a) hydrogen,
(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8, heterocyclyl, heteroaryl, cycloalkyl or aryl,

(c) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(d) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(e) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7, or

(f) cycloalkyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7;

R5 and R8 are each independently:

(a) hydrogen, or
(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, CONR6R7, NR6R7, heterocyclyl, heteroaryl, cycloalkyl or aryl;

R6 and R7 are each independently:

(a) hydrogen,
(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR5R8, NR5R8, NR5COR8, heterocyclyl, heteroaryl, cycloalkyl or aryl,

(c) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR5R8, halogen, CN, CONR5R8, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR5R8,

(d) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR5R8, halogen, CN, CONR5R8, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR5R8,

(e) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR5R8, halogen, CN, CONR5R8, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR5R8,

(f) cycloalkyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR5R8, halogen, CN, CONR5R8, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR5R8, or

(g) R6 and R7 are joined together to form a four to seven member ring.

US Pat. No. 10,485,092

MULTILAYER BUS BOARD

INTERPLEX INDUSTRIES, INC...

1. A multilayer bus board comprising:a multilayer stacked assembly having a plurality of layers including a pair of electrically conductive layers and a dielectric layer disposed between and adjoining each of the conductive layers; and
a molded frame formed of an insulating polymer material, the frame having a peripheral portion encapsulating end portions of the dielectric layer and the conductive layers to maintain the conductive layers and the dielectric layer in position relative to each other, the frame defining an enlarged opening through which an external surface of an outer one of the layers is exposed.

US Pat. No. 10,028,651

SURGICAL VISUALIZATION SYSTEMS AND DISPLAYS

CamPlex, Inc., Germantow...

1. A medical apparatus comprising:at least one video camera configured to acquire video images of a surgical site, said at least one video camera being a surgical microscope camera having a field of view that can be configured to include the surgical site, wherein the surgical microscope camera is configured to provide a surgical microscope view of the surgical site;
a display housing; and
a plurality, of electronic displays disposed within the display housing, each of the plurality of electronic displays comprising a plurality of pixels configured to produce a two-dimensional image, at least one of the electronic displays is configured to produce a two-dimensional image from said surgical microscope camera,
wherein the plurality of electronic displays are configured to present superimposed images in a field of view of a person's eye, the superimposed images comprising at least one image from a first electronic display of the plurality of electronic displays and at least one image from a second electronic display of the plurality of electronic displays, the second electronic display different from the first electronic display, and
wherein said surgical microscope camera is not coupled to a direct view surgical microscope.

US Pat. No. 9,361,917

METHOD TO FABRICATE A BASE PLATE FOR PIEZO ACTUATION

INTRI-PLEX TECHNOLOGIES, ...

1. A method of fabricating a baseplate for a piezoelectric actuator for use in a disk drive, the steps of the method comprising:
providing a plate with a predetermined plate thickness and having first and second major surface and edges;
forming an aperture of a predefined perimeter in the baseplate, leaving a spanning portion extending across the aperture from
a first section on the aperture perimeter to a second different section along the aperture perimeter;

striking in a first direction, substantially normal to the first major surface of the plate, with a cutting punch to shear
the plate at the first and second section of the aperture perimeter by a shear distance less than the plate thickness;

striking the second major surface at the first and second sections of the aperture perimeters with a push back punch in a
second direction substantially normal to the second major surface, reducing the shear distance by less than the plate thickness;
and

leaving the sheared spanning portion in place, whereby the sheared spanning portion prevents interlocking of multiple base
plates packaged together, and adds structural integrity during shipping.

US Pat. No. 9,283,608

DISK SEPARATOR PLATES AND METHOD OF MAKING DISK SEPARATOR PLATES FOR HARD DISK DRIVES

INTRI-PLEX TECHNOLOGIES, ...

1. A method of making disk separator plates for mounting in a hard disk drive, each disk separator plate having a plurality
of mounting apertures for fastening the separator plate to the frame of a hard disk drive, the method comprising:
stamping a separator plate having a top, a bottom, an external edge, and mounting apertures, from a sheet of metal;
extruding a boss having an inner and outer diameter and a predefined height extending from the bottom of the separator plate,
around each mounting aperture; and

counterboring a larger diameter into the boss at the top of the separator plate for a predefined distance from the top of
the separator plate;

whereby a plurality of separator plates are nestable together, spaced apart by a distance predetermined by the offset bosses
of the separator plate fitting into the counterbore of a boss in an adjacent separator plate.

US Pat. No. 10,073,023

LIGHT EXTINCTION TOMOGRAPHY FOR MEASUREMENT OF ICE CRYSTALS AND OTHER SMALL PARTICLES

Plexar Associates, Inc., ...

1. A system, comprising:a support frame at least partially surrounding a cavity through which a flow of air can pass without substantial interference;
a plurality of electromagnetic emitters displaced along the support frame and configured to emit electromagnetic radiation toward the cavity to illuminate at least a cross-section of the flow of air;
a plurality of electromagnetic detectors displaced along the support frame and configured to detect the electromagnetic radiation emitted from the electromagnetic emitters; and
a controller configured to
cycle on-and-off each of the plurality of electromagnetic emitters in an illumination pattern,
acquire a measurement from each of one or more selected electromagnetic detectors during each on-cycle of an electromagnetic emitter,
reconstruct, from a plurality of acquired measurements, an extinction map of the cross-section of the flow of air using a tomography algorithm, and
determine one or more characteristics of particles in the flow of air from the reconstructed extinction map.

US Pat. No. 9,709,229

FLAME SIMULATING ASSEMBLY WITH FLICKER ELEMENT INCLUDING PADDLE ELEMENTS

Dimplex North America Lim...

1. A flame simulating assembly comprising:
at least one light source for producing light;
a screen to which the light from said at least one light source is directed, to provide a plurality of images of flickering
flames thereon;

a rotatable flicker element comprising:
an elongate rod defined by an axis thereof about which the rod is rotatable;
a plurality of paddle elements located in respective predetermined locations on the rod, each said paddle element comprising
at least one body portion having at least one reflective surface thereon, said at least one reflective surface comprising
a central region that is substantially centrally located on said at least one reflective surface and a perimeter region at
least partially located around the central region, the perimeter region substantially defining a perimeter plane;

the paddle elements being located to position the perimeter plane substantially perpendicular to the axis, for intermittently
reflecting the light from said at least one light source from said at least one reflective surface to predetermined regions
on the screen respectively as the flicker element rotates about the axis, to provide the images of flickering flames on the
screen; and

the central region being substantially non-planar and the perimeter region being at least partially planar, to cause the light
reflected therefrom to the screen as the flicker element rotates to have varying intensity at the respective predetermined
regions on the screen.

US Pat. No. 9,333,379

AERIAL FIRE SUPPRESSION SYSTEM

SIMPLEX MANUFACTURING CO....

1. A fire suppression apparatus for fighting fires from a helicopter, comprising:
a tank assembly comprising
(a) a foam tank for housing a foam and configured for attachment to the helicopter, and
(b) a water tank located downstream of the foam tank for housing water and configured for attachment to the helicopter, wherein
the water tank is configured to receive a foam from the foam tank that when mixed with water in the water tank forms a liquid
fire retardant in the water tank;

a pump mounted to and supported on one side of the tank assembly and driven by an electric motor, the pump including an air
induction valve connected to a suction end of the pump, wherein air and the fire retardant are drawn into the suction end
and pressurized by the pump; and

an aimable boom mounted to and supported on an opposite side of the tank assembly and connected to the pump by a conduit,
the boom including a nozzle on a distal end of the boom from which the pressurized fire retardant and air is dispensed toward
a target.

US Pat. No. 9,123,367

SWAGE MOUNT HAVING A MIXTURE OF A CONDUCTIVE MATERIAL AND A COATING MATERIAL AND METHOD OF MANUFACTURING THE SWAGE MOUNT

INTRI-PLEX TECHNOLOGIES, ...

1. A swage mount for a hard disk drive, the swage mount comprising:
a base material;
a mixture of a coating material and gold at a percentage greater than or equal to 8 percent and less than or equal to 14 percent
as a conductive material diffused through the coating material, the mixture covering a predetermined part of the base material;
and

the coating material covering other parts of the base material.

US Pat. No. 10,501,460

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A method for treating a subject suffering from a disease or condition mediated by a bromodomain, said method comprising administering to the subject in need thereof an effective amount of a compound of formula (III),wherein the disease or condition is breast cancer, midline carcinomas, acute myelogenous leukemia, chronic lymphocytic leukemia, non-small cell lung cancer, prostate cancer, or uveal melanoma,
wherein the compound of formula (III) has the following structure:

or a pharmaceutically acceptable salt, solvate, a tautomer, a stereoisomer, or a deuterated analog thereof,
Y1 is N;
R1 is deuterated C1-6alkyl, C1-6alkyl, aryl, aryl-C1-4alkyl, C3-6-cycloalkyl, C3-6- cycloalkylakyl, heteroaryl, heteroalkyl, heterocycloalkyl, heterocycloalkylalkyl, C2-6alkenyl, or C2-6alkynyl, each of which is optionally substituted with from 1-3 Rjgroups,
R2 is H;
R3 is deuterated C1-6alkyl, aryl, aryl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, C3-8cycloalkyl, C3-8 cycloalkenyl, C3-8 cycloalkyl-C1-4alkyl, C2-6 alkynyl, heterocycloalkyl, or heterocycloalkyl-C1-4alkyl, wherein each R3 is optionally substituted with 1-3 substituents independently selected from CN, -OH, -NH2, -NO2, -C(O)OH, - C(S)OH,-C(O)NH2, -C(S)NH2, -NHC(O)NH2, -NHC(S)NH2, -NHS(O)2NH2, -C(NH)N H2, -CH?C(Rn)(Rn), -ORn, -SRn, -OC(O)Rn, -OC(S)Rn, -P(?O)HRn, -P(?O)RnRn, -PH(?O)ORn, - P(?O)(ORn)2, -OP(?O)(ORn)2 , -C(O)H, - O(CO)ORn, -C(O)Rn, -C(S)Rn, -C(O)ORn, -C(S)ORn, -S(O)Rn, -S(O)2Rn, -C(O)NHRn, -C(S)NHRn, -C(O)NRnRn, -C(S)NRnRn, -S(O)2NHRn, -S(O)2NRnRn, -C(NH)NHRn, -C(NH)NRnRn, -NHC(O)Rn, -NHC(S)Rn, -NRnC(O)Rn, -NRnC(S)Rn, -NHS(O)2Rn, -NRnS(O)2Rn, -NHC(O)NHRn, -NHC(S)NHRn, -NRn, -NRnC(O)NH2, -NRnC(S)NH2, -NRnC(O)NHRn, -NRnC(S)NHRn, -NHC(O)NRnRn, -NHC(S)NRnRn, -NRC(O)NRRn, -NRnC(S)NRnRn, -NHS(O)2NHRn, -NRnS(O)2NH2, -NRnS(O)2NHRn, -NHS(O)2NRnRn, -NRnS(O)2NRnRn, -NHRn, Rn, and -NRnRn, wherein each Rn is independently H, C1-6alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, cycloalkyl, or cyclaoalkylylalkyl; or two Rn groups when attached to the same carbon or nitrogen atom are taken together to form a 3- to 6-membered carbocyclic ring or 3- to 8- membered heterocyclic ring having from 1-2 heteroatoms as ring members selected from O, N, and S, wherein the nitrogen or sulfur ring atoms are optionally oxidized, wherein the aliphatic or aromatic portion of Rn is further optionally substituted with from 1-3 Rh;
R4 is H;
R5 is:
each of which is optionally substituted with from 1-2 R11;wherein the wavy line indicates the point of attachment to the rest of molecule and each R11 is independently D, halogen, C1-6alkyl, deuterated C1-6alkyl, C1-4haloalkyl, C1-4haloalkoxy, or CN;
L is —C(R6)(R7)—, —C(O)—, —S(O)—, —S—, —P(O)(Ra)—, —CH?C(Rb)—, or —Si(Rc)(Rc);
R6 is H or D;
R7 is H, D, halogen, —OH, C1-6alkyl, deuterated C1-6alkyl, C2-6alkenyl, C2-6alkynyl, aryl, aryl-C1-4 alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, heterocycloalkyl, heterocycloalkyl-C1-4alkyl, heteroaryl, heteroarylalkyl, C1-6haloalkyl, C1-6haloalkoxy, —ORd, —NRdRd, —C(O)ORd, —OC(O)Rd, —OC(O)ORd, —C(O)Rd, —NHC(O)Rd, —C(O)NRdRd, —SO2Rd, —NHSO2Rd, or —SO2NRdRd,
wherein R7 is further optionally substituted with from 1-3 Rh groups;
Ra is optionally substituted C1-6alkyl, optionally substituted aryl, or optionally substituted heteroaryl;
Rb is H or C1-6alkyl;
each Rc is independently C1-6alkyl or C1-6alkoxy;
each Rd is independently H, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, or aryl;
each Rh is independently halogen, —CN, —OH, —NH2, —NO2, —CH?C(Rk)(Rk), —C(O)OH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —ORi, —SRi, —OC(O)Ri, —OC(S)Ri, —P(?O)HRi, —P(?O)RiRi, —PH(?O)ORi, —P(?O)(ORi)2, —OP(?O)(ORi)2, —C(O)H, —O(CO)ORi, —C(O)Ri, —C(S)Ri, —C(O)ORi, —C(S)OR1, —S(O)Ri, —S(O)2Ri, —C(O)NHRi, —C(S)NHRi, —C(O)NRiRi, —C(S)NRiRi, —S(O)2NHRi, —S(O)2NRiRi, —C(NH)NHRi, —C(NH)NRiRi, —NHC(O)Ri, —NHC(S)Ri, —NRiC(O)Ri, —NRiC(S)Ri, —NHS(O)2Ri, —NRiS(O)2Ri, —NHC(O)NHRi, —NHC(S)NHRi, —NRiC(O)NH2, —NRiC(S)NH2, —NRiC(O)NHRi, —NRiC(S)NHRi, —NHC(O)NRiRi, —NHC(S)NRiRi, —NRiC(O)NRiRi, —NRiC(S)NRiRi, —NHS(O)2NHRi, —NRiS(O)2NH2, —NRiS(O)2NHRi, —NHS(O)2NRiRi, —NRiS(O)2NRiRi, Ri, —NHRi, or —NRiRi,
each Ri is independently C1-6alkyl, aryl, aryl-C1-2alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, heterocycloalkyl, or heterocycloalkyl-C1-4alkyl;
Rj is halogen, —CN, —OH, —NH2, —NO2, —C(O)OH, —C(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —CH?C(Rk)(Rk), —ORk, —SRk, —OC(O)Rk, —OC(S)Rk, —P(?O)HRk, —P(?O)RkRk, —PH(?O)ORk, —P(?O)(ORk)2, —OP(?O)(ORk)2, —C(O)H, —O(CO)ORk, —C(O)Rk, —C(S)Rk, —C(O)ORk, —C(S)ORk, —S(O)Rk, —S(O)2Rk, —C(O)NHRk, —C(S)NHRk, —C(O)NRkRk, —C(S)NRkRk, —S(O)2NHRk, —S(O)2NRkRk, —C(NH)NHRk, —C(NH)NRkRk, —NHC(O)Rk, —NHC(S)Rk, —NRkC(O)Rk, —NRkC(S)Rk, —NHS(O)2Rk, —NRkS(O)2Rk, —NHC(O)NHRk, —NHC(S)NHRk, —NRkC(O)NH2, —NRkC(S)NH2, —NRkC(O)NHRk, —NRkC(S)NHRk, —NHC(O)NRkRk, —NHC(S)NRkRk, —NRkC(O)NRkRk, —NRkC(S)NRkRk, —NHS(O)2NHRk, —NRkS(O)2NH2, —NRkS(O)2NHRk, —NHS(O)2NRkRk, —NRkS(O)2NRkRk, —NHRk, or —NRkRk; and
each Rk is independently H, C1-6alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, cycloalkyl, or cycloalkylalkyl; or two Rk groups when attached to the same carbon or nitrogen atom are taken together to form a 3- to 6-membered carbocyclic ring or 3- to 8-membered heterocyclic ring having from 1-2 heteroatoms as ring members selected from O, N, and S, wherein the nitrogen or sulfur ring atoms are optionally oxidized, and wherein Rk is optionally substituted with from 1-3 Rh.

US Pat. No. 10,426,760

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method for treating a subject with melanoma, thyroid cancer, or colorectal cancer, said method comprising administering to the subject:an effective amount of a compound of formula (Ia):

or a pharmaceutically acceptable salt thereof,
wherein:
L1 is a bond or —N(H)C(O)—;
each R1 is —N(R5)—C(X)—R7, lower alkyl, or optionally substituted heteroaryl;
R2 is hydrogen or halogen;
R4 is hydrogen;
R3 is optionally substituted lower alkyl or optionally substituted aryl;
m is 0, 1, 2, or 3;
Ar is a monocyclic heteroaryl containing 5 to 6 atoms wherein at least one atom is nitrogen;
R5 is hydrogen;
X is O; and
R7 is lower alkyl.

US Pat. No. 10,399,975

SYNTHESIS OF A COMPOUND THAT MODULATES KINASES

Plexxikon Inc., Berkeley...

1. A process of preparing a crystalline form of Compound II:
comprising:
(1) adding Compound II to from about 0.4% v/v wet methyl tert-butyl ether (MTBE) to about 1.5% v/v wet MTBE to provide a reaction mixture;
(2) refluxing the reaction mixture;
(3) cooling the reaction mixture to about room temperature; and
(4) isolating the crystalline form of Compound II from the reaction mixture.

US Pat. No. 9,834,331

SCENT PERMEATION CONTAINER SEAL, CONTAINER INCLUDING SAID SEAL AND METHODS OF MAKING SAID SEAL AND SAID CONTAINER

Tekni-Plex, Inc., Wayne,...

1. An induction seal for a container containing a substance having a scent or aroma, comprising:
a one-piece, multi-layer body including a polyester film layer, a layer of EPE foam, a layer of aluminum foil and a sealing
layer;

at least one slit extending through fewer than all of the polyester film layer, the layer of EPE foam, the layer of aluminum
foil and the sealing layer of said multi-layer body, said at least one slit configured to pass scent or aroma from the substance
through the seal while restricting the passage of the substance through the seal; and

wherein the intact layer or layers of the multi-layer induction seal through which the at least one slit does not extend are
non-venting, such that they are configured to not permit a free flow of air or gas from inside the container to outside of
the container.

US Pat. No. 9,415,141

METHOD FOR MAKING BIODEGRADABLE ANTI-ADHESION MEMBRANES FOR CARDIAC SURGERY

Federal State Budgetary I...

1. A method for manufacturing a biodegradable membrane for preventing adhesion formation after cardiac surgery, the method
comprising:
dissolving a polyhydroxybutyrate/hydroxyvalerate (PHBV) copolymer in chloroform to form a composition;
adding at least one biologically active substance to the composition;
adding poly (D, L-lactide) to the composition and further dissolving the composition in the chloroform up to a concentration
of 6% to 9%; and

stirring the composition for about 2 hours using a magnetic stirrer at a temperature up to 35° C.,
wherein a ratio of dry PHBV copolymer and dry poly (D, L-lactide) in the composition is 3:1, and wherein the membrane is produced
by electrostatic spinning.

US Pat. No. 9,063,044

MAGNETIC AGGREGATING AND WASHING DEVICE FOR IN VITRO ASSAYS AND METHODS OF USE THEREOF

PLEXBIO CO. LTD., Taipei...

1. A method for washing a sample in an assay, the method comprising:
a) coupling a microtiter plate with a magnetic structure,
wherein the microtiter plate sits on top of the magnetic structure,
wherein the microtiter plate comprises a well comprising a sample and a plurality of magnetic beads,
wherein the magnetic structure comprises a plurality of magnets each having a first pole and a second pole, the first pole
and the second pole having opposite magnetic properties, and

wherein a first magnet of the magnetic structure and a second magnet of the magnetic structure are oriented in the magnetic
structure such that the first pole of the first magnet faces the first pole of the second magnet, the first magnet adjacent
to the second magnet in the magnetic structure;

b) rotating the microtiter plate such that the microtiter plate and the magnetic structure move together at a first speed
for a first duration to distribute the plurality of magnetic beads in the well, wherein the rotation of the microtiter plate
at the first speed produces a relative centrifugal force that exceeds the magnetic force between the magnetic beads in a well
of the microtiter plate and the magnetic structure; and,

c) rotating the microtiter plate such that the microtiter plate and the magnetic structure move together at a second speed
for a second duration to aggregate a majority of the plurality of magnetic beads at a portion of the well, the second speed
different from the first speed.

US Pat. No. 10,428,067

COMPOUNDS AND METHODS FOR KINASE MODULATION

Plexxikon Inc., Berkeley...

1. A compound having Formula I:or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer, or a deuterated analog thereof, wherein:A is N or —C(Z3)?;
W is —C(R2)? or N;
Z3 is hydrogen or halo;
Z2 is:

L is —SO2—NR6R7, —NHC(O)R4, or —C(O)NR3R4;
R1 is C1-6alkyl, halo, or halo-C1-6alkyl;
R2 is hydrogen, —CH3, —CH2F, —CHF2, —CF3, or halo;
R3 is hydrogen or C1-6alkyl;
R4 is C3-6cycloalkyl, C3-6cycloalkyl-C1-3alkylene, cyano-C3-6 cycloalkyl, cyano-C3-6 cycloalkyl-C1-3alkylene, cyano-C1-6alkylene, heterocycloalkyl, heteroaryl, or —(CH2)—[(CR10)]2-OH, wherein the C3-6cycloalkyl, C3-6cycloalkyl-C1-3alkylene, cyano-C3-6 cycloalkyl, cyano-C3-6 cycloalkyl-C1-3alkyl, cyano-C1-6alkylene, heterocycloalkyl, and heteroaryl are optionally substituted with 1-2 G groups;
or R3 and R4, together with the N atom to which they are attached, join to form a 4-6 membered heterocycloalkyl moiety substituted with 1-2 G groups;
R6 is hydrogen, C1-6alkyl, cyano-C1-6alkylene optionally substituted with 1-2 G groups, or C3-6cycloalkyl optionally substituted with 1-2 G2 groups;
R7 is hydrogen or C1-6alkyl;
or R6 and R7, together with the N atom to which they are attached, join to form a heterocycloalkyl moiety substituted with 1-2 G groups;
R8 is C1-3alkyl, hydroxy-C1-6alkyl, halo-C1-6alkyl, cyano-C1-6alkylene, —[C(R9)2]1-2—C3-6cycloalkyl, —[C(R9)2]1-2-heterocycloalkyl, —[C(R9)2]1-2-heteroaryl, —[C(R9)2]1-2—SO2—C1-3alkyl, —[C(R9)2]1-2—C(O)—C1-3alkyl, —[C(R9)2]1-2—C(O)—N(C1-3alkyl)2, —[C(R9)2]1-2—C(O)—NH2, —[C(R9)2]1-2—C(O)—C3-6cycloalkyl, or —[C(R9)2]1-2—C(O)-heterocycloalkyl, or —CH2—C(O)-pyridyl;
each R9 is independently selected from hydrogen, C1-6alkyl, C3-6cycloalkyl, halo, and halo-C1-6alkyl;
each R10 is C1-3alkyl or two R10, together with the C atom to which they are attached, join to form a C3-6 cycloalkyl;
each G is independently hydroxyl, C1-6alkyl, C3-6 cycloalkyl, or heterocycloalkyl;
each G2 is independently C1-6alkyl, halogen, or cyano;
m is 0, 1, or 2; and
n is 0 or 2;
provided that the compound is not
N-(2-cyano-2-methyl-propyl)-6-[2-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(2-cyano-2-methyl-propyl)-6-[2-[1-(difluoromethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-[1-(difluoromethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-(2-isopropyl-4-methyl-thiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
6-[2-[1-(2-cyanoethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(1-cyano-1-methyl-ethyl)pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-[1-(2-morpholinoethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-(1-isopropyl-3-methyl-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
6-[3-chloro-2-[1-(difluoromethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(1-cyano-1-methyl-ethyl)pyridine-2-carboxamide,
6-[3-chloro-2-(1-isopropyl-3-methyl-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(1-cyano-1-methyl-ethyl)pyridine-2-carboxamide,
N-(1-cyano-1-methyl-ethyl)-6-[2-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide,
N-(2-cyanopropan-2-yl)-6-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)picolinamide,
N-(2-cyanopropan-2-yl)-6-(2-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)picolinamide,
N-(2-cyanopropan-2-yl)-6-(2-(1-(oxetan-3-ylmethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)picolinamide, and
N-(2-cyanopropan-2-yl)-6-(2-(1-((methylsulfonyl)methyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)picolinamide.

US Pat. No. 9,492,065

SURGICAL RETRACTOR WITH VIDEO CAMERAS

CAMPLEX, INC., Germantow...

1. A medical apparatus comprising:
a surgical retractor configured to hold open an incision and thereby provide a pathway for access of surgical tools to a surgical
site, the surgical retractor having a first end, a second end, a retractor frame configured to support surfaces that hold
open the incision from of sides of the incision, and a longitudinal axis extending between the first and second ends, wherein
the pathway extends along the longitudinal axis into the surgical site and the first end is more proximal than the second
end;

a proximal support frame comprising a camera platform and a curved support, the camera platform configured to move along the
curved support the proximal support frame disposed above said retractor frame closer to said first end of said retractor than
said second end of said retractor; and

a plurality of video cameras inwardly facing toward the pathway, the video cameras comprising a distal video camera at a distal
location with respect to said first end of said surgical retractor within said pathway provided by said surgical retractor,
and a proximal video camera attached to the camera platform of said proximal support frame,

wherein said proximal video camera is configured to be moved from one location on said proximal support frame to another location
on said proximal support frame while still coupled to the proximal support frame.

US Pat. No. 9,361,929

DEBRIS REDUCING DISK CLAMP FOR DISK DRIVES

INTRI-PLEX TECHNOLOGIES, ...

1. A disk clamp and fastening screw combination for a disk drive, the disk drive including a hub rotated by a motor with the
fastening screw having a head and a shaft, the shaft threaded into the hub, and at least one storage disk supported on the
hub by the fastening screw and disk clamp combination, the disk clamp comprising a circular member having a center, a top
surface, a bottom surface and an outer diameter, at least one fastening hole centrally located in the circular member, a midsection
having a perimeter surrounding the fastening hole, the midsection having a downward slant from the perimeter toward the fastening
hole at an angle between 0° and ?3.5° from the top surface of the circular member so that when the head of the fastening screw
is tightened against the midsection of the circular member the outer diameter of the head contacts the midsection of the circular
member first, the midsection maintaining a downward slant during tightening of the fastening screw.

US Pat. No. 9,450,815

NETWORK NODE CONNECTION CONFIGURATION

PLEXXI INC., Nashua, NH ...

1. A network node configured to be connected in a network, the network node comprising:
first and second ordered sets of optical input/output fibers, each ordered set including positions 1 to N, wherein each optical
input/output fiber in the first ordered set corresponds in position to a like numbered optical input/output fiber in the second
ordered set, such that the network node is interconnectable with other like nodes upon interconnection of optical input/output
fibers in the first ordered set with like numbered optical input/output fibers of the second ordered set in adjacent nodes,
wherein the optical input/output fibers of the first and second ordered sets define an interconnection arrangement;

first and second communication components coupled to like numbered selected optical input/output fibers of the first and second
ordered sets of optical input/output fibers so as to provide communication between adjacent nodes upon interconnection of
the network node with other nodes having the same interconnection arrangement;

at least one direct optical pass-through connection pathway extending internally from a specified optical input/output fiber
of the first ordered set to a specified optical input/output fiber of the second ordered set that is offset in position from
the position of the specified optical input/output fiber in the first ordered set by one position, wherein each of the at
least one direct optical pass-through connection pathway provides a passive communication pathway through the network node;

a transmitter or receiver being connected to a first selected optical input/output fiber in the first ordered set or a first
selected optical input/output fiber in the second ordered set at a position from which at least one of the at least two chosen
optical input/output fibers is offset by one position;

a first optical component coupled to a second selected optical input/output fiber of the first ordered set and operative to
provide bidirectional communication via the second selected optical input/output fiber of the first ordered set; and

a second optical component coupled to a second selected optical input/output fiber of the second ordered set and operative
to provide bidirectional communication via the second selected optical input/output fiber of the second ordered set,

wherein the specified optical input/output fibers of the first and second ordered sets associated with the at least one direct
optical pass-through connection pathway and, the first and second selected optical input/output fibers of the first and second
ordered sets of optical input/output fibers associated with the first and second optical components, respectively, have positions
in the first and second ordered sets, such that upon series interconnection of a plurality of nodes that have an interconnection
arrangement that is the same as the network node, a plurality of direct optical interconnections having first and second endpoints
corresponding to the first and second optical components are formed between non-adjacent nodes,

wherein a number of direct optical pass-through connection pathways between the first and second endpoints of each direct
optical interconnection define a pass-through reach, and wherein the first and second optical components are endpoints on
at least the direct optical interconnections having the largest pass-through reach in the network formed upon such series
interconnection of the plurality of nodes.

US Pat. No. 9,437,916

FILTER

Mesaplexx Pty Ltd, Queen...

1. A multi-mode cavity filter comprising:
a dielectric resonator body incorporating a piece of dielectric material, the piece of dielectric material having a shape
supporting at least two substantially degenerate resonant modes and one face having a surface; and

a coupling structure on said surface of said one face, said coupling structure including a first plurality of independent
coupling elements arranged to couple input signals into the piece of dielectric material and a second plurality of independent
coupling elements arranged to recover output signals from the piece of dielectric material, wherein the first plurality of
independent coupling elements is distinct from the second plurality of independent coupling elements.

US Pat. No. 9,140,280

LATCH TO THE CORE FASTENER

Interplex Nascal, Inc., ...

1. A coupling system, comprising:
a hub having a first latch opening disposed therein and defining a first latch opening space;
a first latching feature disposed in the first latch opening and irremovably attached to, and extending from, an inner wall
of the first latch opening into the first latch opening space; and

a first fastener, disposed in the first latch opening, comprising a first set of opposing prongs releasably coupled to the
first latching feature positioned between the first set of opposing prongs,

wherein the first fastener is separate from the hub and configured to be completely removed from the first latch opening,
and

wherein the first latch opening is sized to provide a close slide fit to a base portion of the first fastener.

US Pat. No. 9,681,833

COEXTRUDED PLASTIC CAPILLARY TUBE

Tekni-Plex, Inc., Wayne,...

1. A capillary tube comprising:
a coextruded plastic multilayer capillary tube having a tubular sidewall defining a central channel and comprising at least
two coextruded polymer layers coaxially disposed along an axial length of the tube between open proximal and distal ends of
the tube, the tubular sidewall having an inner diameter sized to permit an aqueous or aqueous based fluid to flow into the
central channel by capillary action through an open end of the tube,
the at least two coaxial coextruded polymer layers comprising:
an innermost layer defining the surface of the central channel comprising a polyether block polyamide (PEBA) polymer material;
and

an outer layer of a material having a flexural modulus of at least about 250,000 pounds per square inch (psi).

US Pat. No. 9,642,606

SURGICAL VISUALIZATION SYSTEM

CamPlex, Inc., Germantow...

1. A surgical visualization system comprising:
a surgical retractor configured to hold open an incision, the surgical retractor having a plurality of cameras disposed thereon;
a surgical tool having at least one camera disposed thereon;
at least one video camera configured to acquire video images of a surgical site, said at least one video camera being a surgical
microscope camera having a field of view that can be configured to include the surgical site, wherein the surgical microscope
camera is configured to provide a surgical microscope view of the surgical site;

a binocular viewing platform comprising a housing and a plurality of oculars, the plurality of oculars configured to provide
views of at least one display disposed in the housing; and

electronics in communication with said at least one display and configured to display respective images from any one of said
surgical microscope camera, at least one of said plurality of cameras on said surgical retractor and said camera on said surgical
tool for viewing on said at least one display so that said images are viewable through said plurality of oculars;

wherein said surgical microscope camera is not coupled to a direct view surgical microscope.
US Pat. No. 9,284,423

CROSSLINKABLE COMPOSITION CROSSLINKABLE BY REAL MICHAEL ADDITION (RMA) REACTION

Nuplex Resins B.V., Berg...

1. A crosslinkable composition comprising
a. a component A with at least 2 RMA donor groups being acidic protons C—H in activated methylene or methine groups, and
b. a component B with at least 2 RMA acceptor groups being activated unsaturated groups, and
c. a catalyst system C that contains, or is able to generate, a basic catalyst capable of activating the RMA reaction between
components A and B,

d. wherein the cross-linkable composition further comprises an X—H group containing component D that is also a RMA addition
donor reactable with component B under the action of catalyst C, wherein X is N, P, O, S, or wherein X is C as part of an
acidic methyl group, wherein component A is malonate or acetoacetate, and wherein the X—H group of component D has a higher
acidity than the C—H groups in component A, wherein component D has a pKa, defined in aqueous environment, of at least one
unit less than that of the C—H groups in component A.

US Pat. No. 9,181,452

CROSSLINKABLE COMPOSITION CROSSLINKABLE WITH A LATENT BASE CATALYST

NUPLEX RESINS B.V., Berg...

1. A crosslinkable polymer coating composition comprising at least one crosslinkable component crosslinkable with a base catalyst
and a latent base crosslinking catalyst, which crosslinkable composition has a solids content of at least 55 wt % (dry weight
after crosslinking relative to the total weight of the crosslinking composition) and wherein the latent base catalyst is a
substituted carbonate salt according to formula 1

wherein X+represents a non-acidic cation and wherein R is hydrogen, alkyl, aryl or aralkyl group and in which latent base catalyst,
on drying, the carbonate salt decomposes releasing carbon-dioxide to produce a strong base catalysing crosslinking of the
at least one crosslinkable components.

US Pat. No. 9,119,819

ORAL LIQUID COMPOSITIONS OF RHEIN OR DIACEREIN

Wockhardt Ltd., Bandra-K...


wherein said composition exhibits a dissolution profile such that more than 75% of diacerein is released within 30 minutes,
wherein the release profile is measured in Apparatus 2 (USP, Dissolution, paddle, 75 rpm) using 1000 ml of pH 5.7 phosphate
buffer at 37° C.±0.5° C.; and,

wherein said composition results in a reduction of undesirable effects of soft stools.

US Pat. No. 9,739,433

FLAME SIMULATING ASSEMBLY WITH FLICKER ELEMENT INCLUDING PADDLE ELEMENTS

Dimplex North America Lim...

1. A flame simulating assembly comprising:
at least one light source for producing light;
a screen to which the light from said at least one light source is directed, to provide
a plurality of images of flickering flames thereon;
a rotatable flicker element comprising:
an elongate rod defined by an axis thereof about which the rod is rotatable;
a plurality of paddle elements located in respective predetermined locations on the rod, each said paddle element comprising
at least one body portion having at least one reflective surface thereon, said at least one reflective surface comprising
a central region and a perimeter region at least partially located around the central region, the perimeter region at least
partially defining a perimeter plane;

the paddle elements being located in the respective predetermined locations therefor to position the perimeter plane substantially
perpendicular to the axis, for intermittently reflecting the light from said at least one light source from said at least
one reflective surface to predetermined regions on the screen respectively as the flicker element rotates about the axis,
to provide the images of flickering flames on the screen;

the central region being substantially non-planar and the perimeter region being at least partially planar, to cause the light
reflected therefrom to the screen as the flicker element rotates to have varying intensity at the respective predetermined
regions on the screen; and

the perimeter region comprising at least one middle part and at least one side part, said at least one middle part being at
least partially defined by at least one channel partially separating said at least one middle part and said at least one side
part.

US Pat. No. 9,681,796

INTERFACE FOR VIEWING VIDEO FROM CAMERAS ON A SURGICAL VISUALIZATION SYSTEM

CamPlex, Inc., Germantow...

1. A surgical visualization system comprising:
a plurality of cameras configured to acquire video images of a surgical site, at least one of the plurality of cameras being
an endoscope camera and configured to acquire video images within the surgical site;

an auxiliary optical assembly comprising at least one of the plurality of cameras, the at least one of the plurality of cameras
being a surgical microscope camera having a field of view that can be configured to include the surgical site, wherein the
surgical microscope camera is configured to provide a surgical microscope view of the surgical site;

a binocular viewing assembly comprising a housing and a plurality of oculars, the plurality of oculars configured to provide
views of at least one display disposed in the housing, the plurality of oculars comprising a left ocular and a right ocular
each being tubular;

a viewing articulating arm, the binocular viewing assembly disposed on the viewing articulating arm, the viewing articulating
arm configured to adjust a position of the binocular viewing assembly;

a second articulating arm, the auxiliary optical assembly disposed on the second articulating arm so that the auxiliary optical
assembly can be positioned independently of the binocular viewing assembly; and

an image processing system in communication with the at least one display and the plurality of cameras including the surgical
microscope camera, the image processing system comprising processing electronics,

wherein the image processing system is configured to:
receive the video images acquired by the plurality of cameras including the surgical microscope camera;
receive input from a user indicating a selection of the endoscope camera or the surgical microscope camera;
based on the selection, switch between providing output video images based on the video images acquired by the endoscope camera
and providing output video images based on the video images acquired by the surgical microscope camera; and

display on the at least one display disposed in the housing the output video images that are provided based on the selection,
the output video images comprising video images acquired by the endoscope camera, video images acquired by the surgical microscope
camera, or both video images acquired by the endoscope camera and video images acquired by the surgical microscope camera,

wherein the surgical microscope camera is not coupled to a direct view surgical microscope, and
wherein the auxiliary optical assembly is smaller than the binocular viewing assembly.

US Pat. No. 9,492,073

BINOCULAR VIEWING ASSEMBLY FOR A SURGICAL VISUALIZATION SYSTEM

CAMPLEX, INC., Germantow...

1. A medical apparatus comprising:
a retractor configured to hold open an incision to provide a pathway for access of surgical tools to a surgical site, said
retractor comprising portions configured to be disposed about an open central region centrally located between said retractor
portions so as to permit access of surgical tools to the surgical site through said open central region;

a plurality of cameras configured to acquire video images of the surgical site, at least one of the plurality of cameras comprising
a first camera disposed on the retractor and configured to acquire video images within the opening provided by the retractor,
wherein said first camera of the plurality of cameras is configured to provide first video images, the first video images
being stereo video images;

an auxiliary optical assembly comprising a left-eye camera and a right-eye camera included in said plurality of cameras, said
left-eye camera and said right-eye camera configured to provide a stereoscopic surgical microscope view of the surgical site
and to provide second stereo video images corresponding to said stereoscopic surgical microscope view, said left-eye camera
and said right-eye camera configured to be disposed left and right with respect to each other and with respect to the surgical
sight to provide left and right views thereof;

a binocular viewing assembly comprising a housing and a plurality of oculars, the plurality of oculars configured to provide
views of at least one display disposed in the housing, said plurality of oculars including a left ocular and a right ocular
similarly disposed left and right with respect to said surgical site so as to coincide with said left-eye camera and said
right-eye camera, said at least one display configured to receive and to display output video images based on the first stereo
video images and the second stereo video images;

a viewing arm, the binocular viewing assembly disposed on the viewing arm, the viewing arm configured to support the binocular
viewing assembly; and

a support, the viewing arm attached to the support;
wherein said left-eye camera and said right-eye camera have optical inputs for receiving light from said surgical site and
the distance from said left and right oculars to said optical input of said left-eye camera and said optical input of said
right-eye camera is not larger than the size of said binocular viewing assembly such that when in use, a surgeon can ergonomically
perform surgery at a surgical site beneath the auxiliary optical assembly while viewing through the plurality of oculars the
output video images of the surgical site displayed on said at least one display, and

wherein said left-eye camera and said right-eye camera are not coupled to a direct view surgical microscope.

US Pat. No. 10,412,455

IMAGE MANAGEMENT DEVICE

RIPPLEX INC., Tokyo (JP)...

1. An image management device comprising:a storage part configured to store an identification information and an image information, the identification information identifying an external device connectable to a first information terminal from another external device, the storage part being configured to correlate the identification information with the image information;
a communication part;
a first receiving control part configured to control the communication part so as to receive the identification information from a second information terminal, the second information terminal being different from the first information terminal and connected with the external device; and
a transmitting control part configured to control the communication part so as to read the image information from the storage part and transmit the image information to the second information terminal, the image information being correlated with the identification information received by the first receiving control part.

US Pat. No. 10,019,815

METHODS AND SYSTEMS FOR IMAGE DIFFERENTIATED MULTIPLEX ASSAYS

PLEXBIO CO., LTD., Taipe...

1. A method for measuring flatness along a Z-axis of a detection stage, the method comprising:(a) at an electronic device comprising an objective, a light source, a camera, and the detection stage, positioning a substantially flat substrate on the detection stage perpendicular to the objective, the camera, and the light source;
(b) obtaining two or more images of a first XY coordinate on a substantially flat substrate positioned on the detection stage, wherein the two or more images represent different Z coordinates at the first XY coordinate;
(c) determining a sharpest Z coordinate at the first XY coordinate based on sharpness of the two or more images representing different Z coordinates at the first XY coordinate;
(d) obtaining two or more images of a second XY coordinate spaced apart from the first XY coordinate on the substantially flat substrate, wherein the two or more images of the second XY coordinate represent different Z coordinates at the second XY coordinate;
(e) determining a sharpest Z coordinate at the second XY coordinate based on sharpness of the two or more images representing different Z coordinates at the second XY coordinate;
(f) calculating a difference between the sharpest Z coordinate at the first XY coordinate and the sharpest Z coordinate at the second XY coordinate to measure the flatness of the detection stage along the Z-axis;
(g) positioning an assay plate on the detection stage perpendicular to the objective, the camera, and the light source, wherein the assay plate comprises:
a plurality of encoded microcarriers, and
a solution comprising at least a first analyte, wherein at least a first encoded microcarrier of the plurality comprises a capture agent specific for the first analyte;
(h) obtaining a first image of the assay plate, wherein first image comprises an image of the code of the first encoded microcarrier; and
(i) obtaining a second image of the assay plate, wherein the second image detects an amount of the first analyte bound to the first encoded microcarrier by the capture agent.

US Pat. No. 9,702,486

POLYURETHANE-POLYETHYLENE DELAMINATION RESISTANT TUBING WITH GAS BARRIER PROPERTIES

Tekni-Plex, Inc., Wayne,...

1. A tube comprising an inner layer, an outer layer and a barrier layer disposed between the inner layer and the outer layer,
wherein the barrier layer is bound to the outer layer by a layer of adhesive disposed between the outer layer and the barrier
layer and the barrier layer is bound to the inner layer by a layer of adhesive disposed between the inner layer and the barrier
layer, wherein the inner layer comprises a polyethylene, the outer layer comprises a thermoplastic polyurethane and the barrier
layer comprises a material that acts as a barrier to gas.

US Pat. No. 9,629,523

BINOCULAR VIEWING ASSEMBLY FOR A SURGICAL VISUALIZATION SYSTEM

CAMPLEX, INC., Germantow...

1. A medical apparatus comprising:
a retractor configured to hold open an incision to provide a pathway for access of surgical tools to a surgical site, said
retractor comprising portions configured to be disposed about an open central region centrally located between said retractor
portions so as to permit access of surgical tools to the surgical site through said open central region;

a plurality of cameras configured to acquire video images of the surgical site, at least one of the plurality of cameras comprising
a first camera disposed on the retractor and configured to acquire video images within the opening provided by the retractor,
wherein said first camera of the plurality of cameras is configured to provide first video images, the first video images
being stereo video images;

an auxiliary optical assembly comprising a left-eye camera and a right-eye camera included in said plurality of cameras, said
left-eye camera and said right-eye camera configured to provide a stereoscopic surgical microscope view of the surgical site
and to provide second stereo video images corresponding to said stereoscopic surgical microscope view, said left-eye camera
and said right-eye camera configured to be disposed left and right with respect to each other and with respect to the surgical
sight to provide left and right views thereof;

a binocular viewing assembly comprising a housing and a plurality of oculars, the plurality of oculars configured to provide
views of at least one display disposed in the housing, said plurality of oculars including a left ocular and a right ocular
similarly disposed left and right with respect to said surgical site so as to coincide with said left-eye camera and said
right-eye camera, said at least one display configured to receive and to display output video images based on the first stereo
video images and the second stereo video images;

a viewing arm, the binocular viewing assembly disposed on the viewing arm, the viewing arm configured to support the binocular
viewing assembly; and

a support, the viewing arm attached to the support;
wherein said left-eye camera and said right-eye camera have optical inputs for receiving light from said surgical site and
the distance from said left and right oculars to said optical input of said left-eye camera and said optical input of said
right-eye camera is not larger than the size of said binocular viewing assembly such that when in use, a surgeon can ergonomically
perform surgery at a surgical site beneath the auxiliary optical assembly while viewing through the plurality of oculars the
output video images of the surgical site displayed on said at least one display, and

wherein said left-eye camera and said right-eye camera are not coupled to a direct view surgical microscope.
US Pat. No. 9,534,081

CROSSLINKABLE COMPOSITION CROSSLINKABLE WITH A LATENT BASE CATALYST

NUPLEX RESINS B.V., Berg...

1. A crosslinkable composition comprising a base crosslinking catalyst and reactive components A, A2 and B, wherein A and
B each comprising at least 2 reactive groups wherein the at least 2 reactive groups of component A are acidic protons (C—H)
in activated methylene or methine groups and the at least 2 reactive groups of component B are activated unsaturated groups
(C?C) to achieve crosslinking by Real Michael Addition (RMA) reaction, wherein the component A2 comprises reactive acidic
protons, and wherein A2 has a higher acidity than component A and is reactive towards component B with an RMA reaction.

US Pat. No. 9,340,349

STANDARD FOOTPRINT EGG CARTON FOR HOLDING UP TO JUMBO SIZE EGGS

Tekni-Plex, Inc., Wayne,...

1. A plastic egg carton comprising:
a tray and a lid hingedly connected to the tray for pivoting between open and closed positions, the tray and the lid having
respective peripheral edges that mate with each other in the closed position, the egg carton having in the closed position
a length, a width and a height;

the tray having a plurality of cells for receiving individual eggs, the cells being arranged successively adjacent each other
along the length and width of the carton in a matrix of cells;

each cell having a bottom and a flexible outwardly curved sidewall extending upwardly from the bottom to form a corresponding
one of the cells;

the lid having a plurality of ovoid shaped contoured portions, axially aligned with the height of the carton in the closed
position, that mate with axially align the eggs in the cells of the tray;

the tray having a plurality of cell posts extending above the peripheral edge of the tray, each cell post having a central
axis aligned with the height of the carton and being formed at an intersection of four adjacent cells as a central dome and
an extension of the sidewalls of the four adjacent cells, each cell post having four generally planar ramp surfaces, each
planar ramp surface being disposed between the outwardly curved sidewalls of two adjacent cells and on a different one of
the four sidewall extensions at an angle to the axis of the cell post to provide resistance to compressive forces in the axial
direction; and

the lid having a plurality of lid posts, each lid post being axially aligned with a complimentary cell post and comprising
a central crown and four fingers extending downwardly toward the tray, each finger having a complimentary planar ramp surface
adapted to engage one of the four ramp surfaces of the complimentary cell post when the tray and lid are in the closed position
and axial compressive forces are present to resist distortion of the cell and lid posts such that the crown and dome need
not engage, while the flexible cell sidewalls yield and flex to protectively hold eggs in the cells.

US Pat. No. 9,181,453

CROSSLINKABLE COMPOSITION CROSSLINKABLE WITH A LATENT BASE CATALYST

NUPLEX RESINS B.V., Berg...

1. A crosslinkable polymer composition comprising reactive components A and B each comprising at least 2 reactive groups wherein
the at least 2 reactive groups of component A are acidic protons (C—H) in activated methylene or methine groups and the at
least 2 reactive groups of component B are activated unsaturated groups (C?C) to achieve crosslinking by Real Michael Addition
(RMA), wherein the component A is a malonate containing component and wherein components A and B react on drying of the crosslinkable
polymer composition by deblocking of latent base catalyst C by evaporation of carbon dioxide, which latent base crosslinking
catalyst, is a substituted carbonate salt according to formula 1
wherein X+ represents a non acidic cation and wherein R is hydrogen, alkyl, aryl or aralkyl group.

US Pat. No. 9,127,004

NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS

Wockhardt Ltd., Bandra-K...

1. A pharmaceutical composition comprising a compound of Formula (I)
or a stereoisomer or a pharmaceutically acceptable salt thereof;wherein:
Q is a monocyclic or polycyclic aromatic hydrocarbon group wherein one or more carbon atoms have been replaced with hetero
atoms selected from the group consisting of nitrogen, oxygen and sulfur;

R1 is:

hydrogen,
(CO)n—R3, or

COOR4,

n is 0, 1 or 2;
R2 is:

(a) SO3M,

(b) SO2NH2,

(c) PO3M,

(d) CH2COOM,

(e) CF2COOM,

(f) CHFCOOM, or
(g) CF3;

M is hydrogen or a cation;
R3 is:

(a) hydrogen,
(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8, NR5CONR6R7,

(c) CN,
(d) NR6R7,

(e) CONR6R7,

(f) NHCONR6R7,

(g) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(h) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(i) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(j) cycloalkyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(k) cycloalkyl substituted with C1-C6 alkyl wherein C1-C6 alkyl is further substituted with one or more substituents independently selected from OR5, NR6R7, halogen, CN, or CONR6R7, or

(l) OR8;

R4 is:

(a) hydrogen,
(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR6R7, NR6R7, NR5COR8,

(c) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(d) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7,

(e) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7, or

(f) cycloalkyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR6R7, halogen, CN, CONR6R7, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR6R7;

R5 and R8 are each independently:

(a) hydrogen, or
(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, CN, CONR6R7, NR6R7;

R6 and R7 are each independently:

(a) hydrogen,
(b) C1-C6 alkyl optionally substituted with one or more substituents independently selected from halogen, OR5, CN, COOR5, CONR5R8, NR5R8, NR5COR8,

(c) aryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR5R8, halogen, CN, CONR5R8, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR5R8,

(d) heterocyclyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR5R8, halogen, CN, CONR5R8, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR5R8,

(e) heteroaryl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR5R8, halogen, CN, CONR5R8, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR5R8,

(f) cycloalkyl optionally substituted with one or more substituents independently selected from C1-C6 alkyl, OR5, NR5R8, halogen, CN, CONR5R8, SO2-alkyl, SO2-aryl, OSO2-alkyl, OSO2-aryl, or NHCONR5R8, or

(g) R6 and R7 are joined together to form a four to seven member ring.

US Pat. No. 9,124,776

SYSTEMS AND METHODS FOR DOCUMENTING ELECTRONIC MEDICAL RECORDS RELATED TO ANESTHESIA

PLEXUS TECHNOLOGY GROUP, ...

1. A patient monitoring system, comprising:
at least one patient monitoring device for monitoring a physical condition of a patient in an operating room during an operation
on the patient;

a video device for capturing a video image of the patient during the operation and transmitting video data associated with
the video image; and

a controller unit located in the operating room and configured to control an infusion device coupled to the patient, the controller
unit including

a communication interface for communicating with the at least one patient monitoring device and the video device, and
a user interface having a display for displaying to a user patient data and the video image of the patient during the operation,
and a user input device for receiving at least one of instructions and data from the user;

wherein the video image of the patient is positioned on the display to enable the user to monitor the visual status of the
patient during the operation while entering instructions or data via the input device; and

wherein the user interface includes a touch screen display that integrates the user input device and the display.

US Pat. No. 10,519,177

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A method for treating a subject suffering from a disease or condition mediated by a bromodomain, said method comprising administering to the subject in need thereof an effective amount of a compound of formula (Va),wherein the disease or condition is breast cancer, midline carcinomas, acute myeloid leukemia, chronic lymphocytic leukemia, non-small cell lung cancer, prostate cancer, or uveal melanoma,
wherein the compound of formula (Va) has the following structure:

or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer, or a deuterated analog thereof,
wherein:
R2 is H;
R4 is H;
R6 is H;
R7 is H, —OH, C1-6 alkyl, deuterated C1-6 alkyl, aryl, cycloalkyl, or heterocycloalkyl;
R1 is heteroaryl optionally substituted with from 1-3 Rj groups;
each R1 is independently halogen, —CN, —OH, —NH2, —NO2, —C(O)OH, —(S)OH, —C(O)NH2, —C(S)NH2, —S(O)2NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —C(NH)NH2, —CH?C(Rk)(Rk), —ORk, —SRk, —OC(O)Rk, —OC(S)Rk, —P(?O)HRk, —P(?O)RkRk, —PH(?O)ORk, —P(?O)(ORk)2, —OP(?O)(ORk)2, —C(O)H, —O(CO)ORk, —C(O)Rk, —C(S)Rk, —C(O)ORk, —C(S)ORk, —S(O)Rk, —S(O)2Rk, —C(O)NHRk, —C(S)NHRk, —C(O)NRkRk, —C(S)NRkRk, —S(O)2NHRk, —S(O)2NRkRk, —C(NH)NHRk, —C(NH)NRkRk, —NHC(O)Rk, —NHC(S)Rk, —NRkC(O)Rk, —NRkC(S)Rk, —NHS(O)2Rk, —NRkS(O)2Rk, —NHC(O)NHRk, —NHC(S)NHRk, —NRkC(O)NH2, —NRkC(S)NH2, —NRkC(O)NHRk, —NRkC(S)NHRk, —NHC(O)NRkRk, —NHC(S)NRkRk, —NRkC(O)NRkRk, —NRkC(S)NRkRk, —NHS(O)2NHRk, —NRkS(O)2NH2, —NRkS(O)2NHRk, —NHS(O)2NRkRk, —NRkS(O)2NRkRk, —NHRk, or —NRkRk;
each Rk is independently H, C1-6alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, cycloalkyl, or cycloalkylalkyl; or
two Rk groups when attached to the same carbon or nitrogen atom are taken together to form a 3- to 6-membered carbocyclic ring or 3- to 8-membered heterocyclic ring having from 1-2 heteroatoms as ring members selected from O, N, and S, wherein the nitrogen or sulfur ring atoms are optionally oxidized;
R3 is H, halogen, —CN, optionally substituted C1-6alkyl, optionally substituted deuterated C1-6alkyl, optionally substituted aryl, optionally substituted aryl-C1-4alkyl, optionally substituted heteroaryl, optionally substituted heteroaryl-C1-4alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted C3-8 cycloalkyl-C1-4alkyl, optionally substituted heterocycloalkyl, or optionally substituted heterocycloalkyl-C1-4alkyl; and
R5 is
optionally substituted with from 1 to 2 R11 groups independently selected from D, halogen, C1-6alkyl, deuterated C1-6alkyl, C1-4haloalkyl, C1-4haloalkoxy, and —CN;wherein the wavy line indicates the point of attachment to the rest of molecule.

US Pat. No. 9,657,475

SUSPENDED CEILING UNIT

SIMPLEX STRIP DOORS, LLC,...

4. A drop panel unit, arranged to form a portion of a suspended ceiling system, the drop panel unit comprising:
a frame, with sides of the frame defining a drop panel opening;
a single drop panel, having dimensions for completely covering the drop panel opening, the drop panel having a hinge along
one edge for hinging the drop panel to a side of the frame, to provide for the drop panel to rotate by gravity from a horizontal
orientation to a vertical orientation;

a mounting beam having end portions thereof terminating on opposing sides of the frame and extending completely across between
the opposing sides of the frame, and the mounting beam being disposed to lie above and overlying the drop panel opening defined
by the sides of the frame;

an electromagnetic support disposed between the mounting beam and the drop panel to magnetically hold the drop panel in the
horizontal orientation when electric power is provided to the electromagnetic support; and

a damper disposed between the mounting beam and the drop panel to slow the rotation of the drop panel from the horizontal
orientation to the vertical orientation when electric power to the electromagnetic support is removed.

US Pat. No. 9,425,253

PASSIVATED NANOPARTICLES

Crystalplex Corporation, ...

1. A method for fabricating a passivated semiconductor nanocrystal, said method comprising the steps of:
synthesizing an alloy-gradient nanoparticle, said nanoparticle comprising Cd, S and Se;
applying a semiconductor coating comprising Zn and S over said alloy-gradient nanoparticle, said coating having a wider band
gap than the alloy-gradient nanoparticle to provide a semiconductor coated alloy-gradient nanoparticle;

coating the surface of the semiconductor coated alloy-gradient nanoparticle by growing monolayers of aluminum on the surface
of the semiconductor coated alloy-gradient nanoparticle; and

oxidizing the surface of said aluminum layer by exposure to an ambient environment to form an aluminum oxide layer thereon
to provide a passivated semiconductor nanocrystal;
wherein the semiconductor coated alloy-gradient nanoparticle with the aluminum oxide layer has less of a reduction in fluorescence
than a semiconductor coated alloy-gradient nanoparticle not having an aluminum oxide layer.

US Pat. No. 10,577,366

CRYSTALLINE FORMS OF A COMPOUND THAT INHIBITS BROMODOMAIN

Plexxikon Inc., Berkeley...

1. A crystalline form of Compound I of Form B having the formula:characterized by an X-ray powder diffractogram comprising the following peaks: 19.0, 21.0, and 24.8 °2?±0.2 °2?, as determined on a diffractometer using Cu-K? radiation.

US Pat. No. 10,066,714

DRIVE APPARATUS OF CHAIR ASSEMBLY FOR 4D THEATER

CJ 4DPLEX CO., LTD, Seou...

1. A drive apparatus of a chair assembly for a 4D theater, comprising:a lower plate which is in contact with the ground;
an upper plate which is positioned above the lower plate so as to be spaced apart from the lower plate;
a first actuator which is positioned at a left portion between the lower plate and the upper plate;
a second actuator which is positioned at a right portion between the lower plate and the upper plate; and
a spline device,
wherein the first actuator is installed to have a predetermined first angle with respect to a horizontal centerline of the lower plate,
wherein the second actuator is installed to have a predetermined second angle with respect to the horizontal centerline of the lower plate, and
wherein each of the first angle and the second angle is 10 degrees to 25 degrees.

US Pat. No. 9,882,259

FILTER

Mesaplexx Pty Ltd., Quee...

1. A cavity filter comprising:
at least first and second dielectric resonator bodies, each of said first and second resonator bodies incorporating a piece
of dielectric material having a shape supporting at least a first resonant mode, said first dielectric resonator body adjoining
said second dielectric resonator body at an interface therebetween, said second dielectric resonator body further having a
second interface;

at least one excitation device for at least one of:
establishing an electromagnetic field within said first dielectric resonator body, and
extracting energy from an electromagnetic field located within said first dielectric resonator body;
a layer of electrically conductive material in contact with and covering surfaces of the first dielectric resonator body and
surfaces of the second dielectric resonator body, including said interface therebetween;

at least one aperture in the layer of electrically conductive material on said interface for at least one of inputting signals
into the second dielectric resonator body and outputting signals from the second dielectric resonator body, said at least
one aperture being aligned with said at least one excitation device; and

at least one additional aperture in the layer of electrically conductive material on said second interface of said second
dielectric resonator, said at least one additional aperture not being aligned with said at least one excitation device and
said at least one aperture,

wherein the at least one excitation device is arranged to directly excite the first resonant mode, or directly extract energy
from the first resonant mode, in the second dielectric resonator via the at least one aperture.

US Pat. No. 9,830,949

METHOD AND SYSTEM FOR PROVIDING 4D CONTENT PRODUCTION SERVICE AND CONTENT PRODUCTION APPARATUS THEREFOR

CJ 4DPLEX CO., LTD., Seo...

1. A system for providing a Four-Dimensional (4D) content production service, the system comprising:
a terminal device configured to
transmit content source including at least one of a picture, text and video, synopsis information and video time information
to a content production apparatus,

receive content and special effect codes from the content production apparatus,
select a special effect code corresponding to each play interval of the content, and
transmit special effect selection information indicating selected special effect codes to the content production apparatus;
and

the content production apparatus configured to
produce content using the content source on the basis of the synopsis information and video time information received from
the terminal device,

transmit the produced content and the special effect codes to the terminal device,
receive the special effect selection information from the terminal device, and
generate 4D content using the special effect selection information,
wherein the terminal device is configured to transmit playback information including a play date, time and place,
wherein the playback information is free from synchronization with the content, and
wherein the special effect codes are used to create special effects in synchronization with each play interval of the content.

US Pat. No. 9,536,571

DEBRIS REDUCING DISK CLAMP FOR DISK DRIVES

INTRI-PLEX TECHNOLOGIES, ...

1. A disk clamp for a disk drive, the disk drive including at least one storage disk supported on a hub rotated by a motor,
the disk clamp comprising:
a circular member having a center, a top surface and a bottom surface and an outer diameter, at least one fastening hole centrally
located in the circular member sized for passing a shaft of a fastening screw that threads into the hub, the fastening screw
having a head diameter larger than the shaft diameter, a moat having a plurality of spike trenches surrounding the fastening
hole, each trench angled toward the fastening hole, formed into the circular member around the fastening hole, the moat having
a diameter larger than the fastening hole but smaller than the head diameter of the fastening screw.

US Pat. No. 9,437,910

MULTI-MODE FILTER

Mesaplexx Pty Ltd, Queen...

1. A dielectric resonator body for a multi-mode cavity filter, the resonator body comprising:
a piece of first dielectric material, said piece of first dielectric material having a substantially flat face for mounting
said piece of first dielectric material on a substrate and a plurality of external sides in addition to said substantially
flat face, the piece of first dielectric material having a first dielectric constant and a shape supporting at least a first
resonant mode and a spurious response generated at least partially by a higher-order resonant mode of the first resonant mode;

at least one region of a second dielectric material, said at least one region of said second dielectric material being located
on one of said plurality of external sides of said piece of first dielectric material and not covering all of said one of
said plurality of external sides, said second dielectric material having a second dielectric constant different from said
first dielectric constant; and

a layer of conductive material at least partially coating an outer surface of said piece of first dielectric material and
said at least one region of second dielectric material, said substantially flat face being substantially not covered by said
layer of conductive material,

whereby the presence of the at least one region of second dielectric constant alters the frequency separation between the
first resonant mode and the spurious response.

US Pat. No. 9,145,752

CLAMPING ARRANGEMENT

Plexus Holdings, PLC., A...

1. A clamping arrangement for clamping a first tubular well casing and a second tubular well casing wherein the first tubular
well casing and the second tubular well casing are axially aligned and extend in opposite directions such that an end of the
first well casing abuts an end of the second well casing, the arrangement comprising:
a collar having an internal surface and an externally tapered surface;
an annular component with an internally tapered surface arranged to cooperate with the tapered surface of the collar; and
a continuous tubular member having an internal surface and an external surface, and the tubular member being located between
the collar and the first and second tubular well casings, such that the internal surface of the tubular member contacts an
external surface of both of the first and second well casings,

wherein the collar and the annular component are relatively axially moveable between a first position in which the tapered
surface of the annular component exerts no radial force on the collar and a second position in which the tapered surface of
the annular component exerts sufficient radial force to urge the collar inwardly so as to elastically deform the tubular member
such that the internal surface of the tubular member simultaneously grips and abuts the external surfaces of both the first
tubular well casing and the second tubular well casing so as to form a seal between the tubular member and the first well
casing and a seal between the tubular member and the second well casing.

US Pat. No. 9,115,131

NITROGEN CONTAINING COMPOUNDS AND THEIR USE

Wockhardt Ltd., Bandra-K...

1. A compound of Formula (I)

wherein said compound having X-ray powder diffraction peaks at: 5.18 (±0.2), 5.33 (±0.2), 10.21 (±0.2), 17.52 (±0.2), 18.57
(±0.2), 19.37 (±0.2), 20.29 (±0.2), 25.40 (±0.2), 26.39 (±0.2) and 30.52 (±0.2) degrees 2 theta.

US Pat. No. 10,226,125

EFFECT CONTROL SYSTEM OF SCREENING FACILITY CHAIR AND METHOD THEREOF

CJ 4DPLEX CO., LTD., Seo...

1. An effect control system of a screening facility chair, the system comprising:an input device for transmitting chair angle control information or effect control information input from a user to a management server;
the management server for transmitting the chair angle control information or the effect control information to a corresponding motion chair;
a first motion chair for adjusting a slope according to the chair angle control information and providing an effect synchronized with an image according to the effect control information, and
a second motion chair placed in a front row of the first motion chair,
wherein a nozzle angle of an injector arranged on a backside of each of the first motion chair and the second motion chair is adjusted according to slope of the first motion chair or the second motion chair.

US Pat. No. 10,022,041

HYDRAULIC SYSTEM FOR SURGICAL APPLICATIONS

CamPlex, Inc., Germantow...

1. A surgical visualization system comprising:a surgical retractor configured to hold open an incision and thereby provide a pathway for access of surgical tools to a surgical site, said retractor comprising portions configured to be disposed about an open central region centrally located between said retractor portions so as to permit access of surgical tools to the surgical site through said open region;
at least one camera configured to acquire video images of the surgical site, said at least one camera disposed on the retractor and configured to acquire video images within said surgical site to which the retractor provides access; and
a hydraulic pressure system including at least one valve to generate fluid pulses, a part of said hydraulic pressure system disposed on said retractor, said part of said hydraulic pressure system configured to deliver said fluid pulses and pulses of pressurized air to an optical component of said at least one camera, said fluid pulses and said pulses of pressurized air reducing image obscuration by said fluid pulses being sufficiently brief, low volume and high pressure pulses such that said fluid pulses remove obstructions from said optical component and said fluid pulses are removed by said pulses of pressurized air before evaporating on said optical component.

US Pat. No. 10,011,415

PACKING TRAY FOR STACK OF HOLLOW CONICAL OBJECTS

Tekni-Plex, Inc., Wayne,...

1. A packing tray for conical ice cream cones and other hollow conical objects, the packing tray comprising:a plastic foam sheet having a top wall surrounding one or more recessed elongated pockets, the top wall defining a top reference plane (TRP) and the pockets extending downwardly from the TRP;
each pocket having an elongated axis parallel to the TRP and being configured to hold a stack of nested conical objects between opposing elongated sidewalls, first and second end walls, and a bottom wall;
each pocket further including: a) a conical portion adjacent the first end wall to accommodate an outer conical object of the stack, the conical portion including an upwardly angled wall, at an acute angle to the TRP, disposed between the bottom wall and the first end wall; and b) a rectilinear portion including the bottom wall and disposed adjacent the second end wall to accommodate the remainder of the stack;
a bottom floating pad disposed in the rectilinear portion above the bottom wall, the bottom floating pad comprising a bottom platform disposed upwardly of the bottom wall and joined to the bottom wall by a plurality of expandable flutes;
an angled floating pad disposed in the conical portion above the angled wall, the angled floating pad comprising an angled platform disposed upwardly of the angled wall and joined to the angled wall by a plurality of expandable flutes, wherein a gap is defined between the angled floating pad and bottom floating pad to allow a top open end lip of the outer conical object of the stack to hang freely in the gap between the angled wall and the bottom wall; and
wherein the expandable flutes flex in response to the weight and dimensions of the stack of conical objects enabling the bottom platform to move with respect to the bottom wall and the angled platform to move with respect to the angled wall.

US Pat. No. 9,967,657

DIRECTIONAL LOUDSPEAKER BOX WITH DIRECTIONAL ACOUSTIC TRANSMISSION HOLES

LONGINESTENO TECHNOLOGY C...

1. A directional loudspeaker box with directional acoustic transmission holes, comprising:a hollow housing formed as a barrel-shaped housing, wherein the hollow housing is provided therein with a receiving space, has a front end provided with a front opening in communication with the receiving space, and has a peripheral portion adjacent to the front opening and formed with a plurality of said directional acoustic transmission holes; and each said directional acoustic transmission hole penetrates the hollow housing, is in communication with the receiving space, and has a smaller area than the front opening; and
a loudspeaker fixed in the hollow housing and dividing the receiving space into a front acoustic cavity and a rear acoustic cavity, wherein the front opening and the directional acoustic transmission holes correspond to the front acoustic cavity, the front opening has a central axis coinciding with a central axis of the loudspeaker, each said directional acoustic transmission hole has a central axis forming an included angle with the central axis of the loudspeaker, and each said included angle is a function of an axial distance between a corresponding said directional acoustic transmission hole and the loudspeaker along an axial direction of the hollow housing, wherein the smaller the axial distance between a said directional acoustic transmission hole and the loudspeaker, the larger the included angle formed by the central axis of the directional acoustic transmission hole with the central axis of the loudspeaker, and the larger the axial distance, the smaller the included angle.

US Pat. No. 9,936,863

OPTICAL ASSEMBLY PROVIDING A SURGICAL MICROSCOPE VIEW FOR A SURGICAL VISUALIZATION SYSTEM

CamPlex, Inc., Germantow...

1. A surgical visualization system comprising:a binocular viewing assembly comprising a housing and a pair of eyepieces, said eyepieces configured to provide a view of at least one display disposed in the housing;
an optical assembly configured to provide a surgical microscope view of a surgical site, the optical assembly comprising at least one auxiliary camera;
an articulating arm, the binocular viewing assembly disposed on the articulating arm, the articulating arm configured to adjust a position of the binocular viewing assembly; and
an image processing system in communication with the optical assembly and the at least one display, the image processing system comprising at least one physical processor,
wherein the image processing system is configured to:
receive video images acquired by the at least one auxiliary camera,
provide output video images based on the received video images, and
present the output video images on the at least one display so that the output video images are viewable through the pair of eyepieces,
wherein the optical assembly is configured to provide a working distance that is between about 15 cm and about 45 cm, and
wherein the optical assembly is mounted to an isocenter positioning system, the isocenter positioning system comprising an isocenter track, said isocenter positioning system configured to allow the at least one auxiliary camera to be moved along the isocenter track to a plurality of locations and to position the at least one auxiliary camera such that at said plurality of locations, said at least one auxiliary camera remains a fixed distance away from a common point.

US Pat. No. 9,723,976

OPTICS FOR VIDEO CAMERA ON A SURGICAL VISUALIZATION SYSTEM

CamPlex, Inc., Germantow...

1. A medical apparatus comprising:
at least one video camera comprising imaging optics and an optical sensor, said video camera including an optical path through
said imaging optics to said optical sensor, said at least one video camera configured to acquire video images of a surgical
site, said at least one video camera being a surgical microscope camera having a field of view that can be configured to include
the surgical site, wherein the surgical microscope camera is configured to provide a surgical microscope view of the surgical
site;

a binocular viewing platform comprising a housing and a plurality of oculars, the plurality of oculars configured to provide
views of at least one display disposed in the housing, said at least one video camera disposed on said platform; and

processing electronics in communication with the at least one display, wherein the processing electronics is configured to:
receive video images acquired by the at least one video camera,
provide output video images based on the received video images, and
present the output video images on the at least one display so that the output video images are viewable through the oculars,
wherein said imaging optics comprises a turning mirror or turning prism to fold the optical path underneath the viewing platform
to decrease the physical extent of the at least one video camera under the viewing platform, and

wherein the surgical microscope camera is not coupled to a direct view surgical microscope.

US Pat. No. 9,604,411

MULTI-MATERIAL THREE DIMENSIONAL PRINTER

EoPlex Limited, Hong Kon...

1. A multi-material three dimensional printer, comprising in combination:
a build plate;
a major transport mechanism movable along a major axis of said build plate and a minor transport mechanism movable along a
minor axis of said build plate, said transport mechanisms in engageable coordination with each other,

a first powder dispenser of a plurality of powder dispensers mountable on said major transport mechanism movable over at least
portions of said build plate to place a first powder layer above said build plate;

a binder jet of a plurality of binder jets mountable on said minor transport mechanism movable over at least portions of said
build plate along said minor axis to place binder and bind the first powder together in locations where the binder is placed;

a first powder remover mountable on said major transport mechanism movable over at least portions of said build plate along
said major axis to remove unbound first powder in the first powder layer;

a second powder dispenser of the plurality of powder dispensers movable over at least portions of said build plate along said
major axis to place a second powder layer above said build plate, the second powder different from the first powder.

US Pat. No. 9,325,046

MULTI-MODE FILTER

MESAPLEXX PTY LTD, Eight...

19. A multi-mode cavity filter, comprising:
a dielectric resonator body incorporating a piece of dielectric material, the piece of dielectric material having a shape
such that it can support at least a first resonant mode and a second substantially degenerate resonant mode; and

a coupling structure comprising a first coupling portion and a second coupling portion, the first coupling portion being arranged
to generate a first magnetic field for coupling to at least one of the first resonant mode and the second resonant mode within
the dielectric resonator body, the second coupling portion being arranged to generate a second magnetic field for coupling
to at least one of the first resonant mode and the second resonant mode within the dielectric resonator body, the second magnetic
field having a magnitude and a direction so as to partially cancel the coupling due to the first magnetic field,

wherein the first and second magnetic fields are for coupling primarily to the first resonant mode within the dielectric resonator
body, and

wherein the coupling structure further comprises a third coupling portion and a fourth coupling portion, the third coupling
portion being arranged to generate a third magnetic field for coupling primarily to the second resonant mode within the dielectric
resonator body, the fourth coupling portion being arranged to generate a fourth magnetic field for coupling primarily to the
second resonant mode within the dielectric resonator body, the fourth magnetic field having a magnitude and a direction so
as to partially cancel the coupling due to the third magnetic field.

US Pat. No. 9,184,114

LEAD CARRIER WITH PRINT-FORMED TERMINAL PADS

EOPLEX LIMITED, Hong Kon...

1. A lead carrier and semiconductor combination, comprising in combination:
a plurality of terminal pads formed of electrically conductive material;
said terminal pads each having an upper side opposite a lower side, with edges between said upper side and said lower side;
said terminal pads each being a sintered structure of electrically conductive material;
a semiconductor having a base opposite an upper surface;
a wire bond between at least one of said terminal pads and said semiconductor;
said terminal pads, said semiconductor and said wire bonds at least partially encapsulated within a substantially electrically
non-conductive material; and

wherein said lower side of each said terminal pad and said base of said integrated circuit are each located within a substantially
common plane.

US Pat. No. 10,647,716

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Plexxikon Inc., Berkeley...

1. A process of making compound 13:said process comprising contacting compound 12:with potassium tert-butoxide and iodomethane under conditions sufficient to form compound 13.

US Pat. No. 10,495,275

FLAME SIMULATING ASSEMBLY

Glen Dimplex Americas Lim...

1. A flame simulating assembly for viewing by a viewer positioned in front of the flame simulating assembly, the flame simulating assembly comprising:at least one light source for producing light;
a screen to which the light from said at least one light source is directed, to provide a plurality of images of flames thereon viewable via a front surface of the screen;
at least one trim subassembly, comprising at least one simulated fuel element that is located in front of the screen, and proximal to the front surface of the screen;
a rotatable flicker element located behind the screen, comprising:
an elongate rod defined by an axis thereof about which the rod is rotatable, the rod being positioned at a preselected elevation above a base of the flame simulating assembly and horizontally spaced apart from said at least one simulated fuel element;
a plurality of paddle elements located in respective predetermined locations on the rod, for intermittently reflecting the light from said at least one light source from the paddle elements to the screen respectively as the flicker element rotates about the axis, to provide the images of flames on the screen;
a flame effect element for configuring the light from said at least one light source that is reflected from the flicker element toward at least one predetermined region on the screen located above said at least one simulated fuel element to provide the images of flames therein;
a holding bracket for locating said at least one light source at the preselected elevation and proximal to the flicker element, to provide the images of flames at said at least one predetermined region on the screen;
said at least one trim subassembly being at least partially positioned at the preselected elevation, to at least partially conceal the holding bracket from the viewer; and
the flicker element being positioned to reflect a portion of the light from said at least one light source that is reflected toward the screen to at least partially avoid the flame effect element, to provide a glowing effect in at least one lower region of the screen that is positioned below said at least one simulated fuel element.

US Pat. No. 10,136,053

SYSTEM AND METHOD FOR CONTROLLING A SPECIMEN SCANNER REMOTELY

Innova Plex, Inc., Sugar...

1. A method for controlling a specimen scanner remotely comprising the stepsreceiving by a server real-time image data of a specimen from a specimen scanner over a network, said specimen scanner comprising a stage that supports said specimen, a camera pointed at said stage, one or more lenses, and one or more light sources directed at said stage;
transmitting said real-time image data to a remote computer over said network such that a user at said remote computer can view said real-time image data;
providing by said server a graphical user interface to said remote computer connected to said network, said remote computer not local to said specimen scanner, said graphical user interface operable to receive instructions to control said stage, choose a lens of said one or more lenses, or adjust said one or more light sources;
receiving said instructions by said server from said remote computer;
transmitting said instructions to said specimen scanner to control said specimen scanner based on said instructions, said instructions adjusting said real-time image data being captured by said specimen scanner; and
transmitting to said remote scanner adjusted real-time image data to said remote computer over said network such that said user at said remote computer can view said updated real-time image data.

US Pat. No. 9,800,472

NETWORK NODE CONNECTION CONFIGURATION

PLEXXI Inc., Nashua, NH ...

1. A network switch configured to be connected in a network having a plurality of like network switches, the network switch
comprising:
first and second ordered sets of external connections, wherein each external connection provides direct, optical communication
between an external element outside the network switch and at least one internal element within the network switch;

a first, unidirectional communication component being one of a transmitter and a receiver, the first, unidirectional communication
component being in communication with a first external connection of the first ordered set of external connections;

a second, unidirectional communication component being the other of the transmitter and the receiver, the second, unidirectional
communication component being in communication with a first external connection of the second ordered set of external connections;

a first, bidirectional communication component in communication with a second external connection of the first ordered set
of external connections;

a second, bidirectional communication component in communication with a second external connection of the second ordered set
of external connections, wherein the second external connection of the second ordered set is offset in position from the position
of the second external connection in the first ordered set by at least one position; and

a direct, optical, pass-through connection pathway extending internally from a third external connection in the first ordered
set to a third external connection in the second ordered set that is offset in position from the position of the third external
connection in the first ordered set by at least one position, wherein the direct, optical, pass-through connection pathway
provides a passive communication pathway through the network switch;

wherein, upon interconnection of the network switch into the network by connecting (a) external connections in the first ordered
set of the network switch with like positioned external connections in the second ordered set of a first adjacent network
switch of the plurality of like network switches via a corresponding first plurality of network links and (b) external connections
in the second ordered set of the network switch with like positioned external connections in the first ordered set of a second
adjacent network switch of the plurality of like network switches via a corresponding second plurality of network links, the
network switch is configured to:

provide a direct, unidirectional, optical interconnection between the first, unidirectional communication component within
the network switch and a corresponding second, unidirectional communication component within the first adjacent network switch
or between the second, unidirectional communication component within the network switch and a corresponding first, unidirectional
communication component within the second adjacent network switch;

provide a direct, optical pass-through interconnection that includes the direct, optical, pass-through connection pathway,
the direct, optical pass-through interconnection terminating at one end at a transmitter and at the other end at a receiver,
wherein the transmitter and receiver are disposed in network switches other than the network switch, and

provide a direct, bidirectional, optical interconnection (a) between the first, bidirectional communication component within
the network switch and a corresponding second, bidirectional communication component within a first non-adjacent network switch
such that the direct, bidirectional, optical interconnection includes a direct, optical, pass-through connection pathway within
the first adjacent network switch; or (b) between the second, bidirectional communication component within the network switch
and a corresponding first, bidirectional communication component within a second non-adjacent network switch such that the
direct, bidirectional, optical interconnection includes a direct, optical, pass-through connection pathway within the second
adjacent network switch;

wherein a number of direct, optical, pass-through connection pathways included in the direct, bidirectional, optical interconnection
defines a pass-through reach of the direct, bidirectional, optical interconnection, and

wherein the pass-through reach of the direct, bidirectional, optical interconnection is equal to a largest pass-through reach
in the network.

US Pat. No. 9,615,728

SURGICAL VISUALIZATION SYSTEM WITH CAMERA TRACKING

CamPlex, Inc., Germantow...

1. A method comprising:
inserting a retractor into an opening in a body through an incision, the retractor comprising a plurality of video cameras
disposed thereon; and

electronically tracking the locations of said video cameras;
wherein said electronically tracking comprises tracking the position of a first video camera relative to the position of a
second video camera.

US Pat. No. 9,559,398

MULTI-MODE FILTER

Mesaplex Pty Ltd., Queen...

1. A multi-mode cavity filter comprising:
a dielectric resonator, said dielectric resonator including a piece of dielectric material, said piece of dielectric material
having a substantially cubic shape having six sides, whereby said dielectric resonator is capable of supporting multiple degenerate
resonant modes in parallel, said piece of dielectric material being free of cutouts and coupling structures extending therewithin;

a covering of conductive material on five of said six sides of said piece of dielectric material, wherein said sixth side
of said piece of dielectric material is not covered by said conductive material except around a perimeter thereof so as to
form an aperture allowing signals to be input to and output from said dielectric resonator;

a planar coupling structure extending adjacent to said sixth side of said piece of dielectric material within said aperture
for coupling to said multiple degenerate resonant modes in parallel for at least one of coupling input signals to the dielectric
resonator and extracting filtered output signals from the dielectric resonator; and

a printed circuit board structure having at least one ground plane layer, said sixth side of said piece of dielectric material
not covered by said conductive material being in contact with said at least one ground plane layer of said printed circuit
board structure so that said at least one ground plane layer is electrically coupled to the covering of conductive material
around said perimeter of said sixth side, said planar coupling structure being completely between said piece of dielectric
material and said printed circuit board structure, said at least one ground plane layer covering said aperture to minimize
any leakage of electromagnetic energy from said dielectric resonator.

US Pat. No. 9,406,988

MULTI-MODE FILTER

Mesaplexx Pty Ltd, Queen...

1. A multi-mode cavity filter comprising:
a dielectric resonator body incorporating a piece of dielectric material, the piece of dielectric material being free of cutouts
and holes for coupling probes and having a shape supporting at least a first resonant mode and a second substantially degenerate
resonant mode;

a conductive layer substantially covering the dielectric resonator body but having one or more apertures therein allowing
access to a surface of the dielectric resonator body; and

a coupling structure arranged in an aperture of the one or more apertures, said coupling structure being on or contacting
the surface of the dielectric resonator body, said coupling structure comprising at least one coupling path for at least one
of coupling an input signal to the first and second resonant modes and coupling an output signal from the first and second
resonant modes, the coupling path having an open-circuit end located adjacent to an edge of the aperture for controlling a
strength of electric field generated by the coupling structure,

wherein the open-circuit end is a first open-circuit end, wherein the edge of the aperture is a first edge of the aperture,
and wherein the coupling path comprises a second open-circuit end located adjacent to a second edge of the aperture, and

wherein the first open-circuit end is located a first distance from the first edge of the aperture, wherein the second open-circuit
end is located a second distance from the second edge of the aperture, and wherein the second distance is greater than the
first distance.

US Pat. No. 9,406,993

FILTER

Mesaplexx Pty Ltd, Queen...

1. A cavity filter comprising:
a dielectric resonator structure including a piece of dielectric material having a shape supporting a first resonant mode
and a second resonant mode, said second resonant mode being substantially degenerate with the first resonant mode;

and
a coupling structure for exciting at least one of the first resonant mode and the second resonant mode within the piece of
dielectric material or for extracting energy from at least one of the first resonant mode and the second resonant mode within
the piece of dielectric material,

wherein the coupling structure includes a single patch element in contact with a surface of the piece of dielectric material,
the patch element being a substantially flat conductive element arranged to couple directly to said first and second resonant
modes simultaneously,

the cavity filter further including first and second feedpoints connected to the patch element for feeding input signals to
the patch element or for receiving output signals from the patch element,

wherein the first and second feedpoints are connected to the substantially flat conductive element so as to generate a circularly
polarized field.

US Pat. No. 9,328,187

WATERBORNE HYBRID POLYMER DISPERSION

NUPLEX RESINS B.V., Berg...

1. A process for the manufacture of an auto-oxidatively cross-linking hybrid polymer comprising the step of reacting in a
mini-emulsion process, in the presence of a radical initiator and a surfactant, one or more ethylenically unsaturated monomers
to form an addition polymer, wherein the addition polymer is a vinyl polymer in the presence of a modified auto-oxidatively
crosslinkable (AOC) polymer which is an alkyd resin comprising unsaturated fatty acids, wherein the AOC alkyd polymer is a
hydrophobic alkyd polymer having an acid number from 5 to 20 mg KOH/g and an oil length of the resin between 40 and 95%, and
wherein the modified AOC alkyd polymer is prepared by reaction of (a) a carboxyl functional alkyd polymer and (b) a glycidyl
ester of an acrylic or methacrylic acid.
US Pat. No. 9,260,626

CROSSLINKABLE COMPOSITION

Nuplex Resins B.V., Berg...

1. An RMA crosslinkable composition for making thick coating layers comprising at least one crosslinkable component comprising
reactive components A and B each comprising at least 2 reactive groups wherein the at least 2 reactive groups of component
A are RMA donor group being C—H acidic protons in activated methylene or methine groups, and the at least 2 reactive groups
of component B are RMA acceptor group being activated C?C unsaturated groups, to achieve crosslinking by Real Michael Addition
reaction, said composition further comprising a base catalyst C, an X—H group containing component D, of a nature different
from A, that is also a Michael addition donor reactable with component B under the action of base catalyst C, wherein X is
C, N, P, O or S; wherein component D comprises one or more components D(1) comprising C—H acidic protons, X is C, in activated
methylene, methyl, or methine groups, and one or more components D(2) different from component D(1).

US Pat. No. 10,016,683

REAL TIME PHYSICAL REALITY IMMERSIVE EXPERIENCES HAVING GAMIFICATION OF ACTIONS TAKEN IN PHYSICAL REALITY

GAME COMPLEX, Inc., Aust...

2. A system for gamification of real time physical reality immersive experiences, comprising, in combination:At least a physical medium comprising multiple checkpoints at locations arrayed along a course, each checkpoint comprising a data capture spot to capture choices of multiple independent users traversing the course;
at least one unique identifying device for connecting to and monitoring the progress of at least one of the users;
a master control system operatively linked to the physical medium;
a versioning control system whereby the users may complete real time physical reality immersive experiences simultaneously;
wherein the master control system simultaneously manages, for the multiple independent users, challenge interactions with checkpoints and resultory scoring totals as the users traverse the course, while being interactively viewed by both multiple independent users and other observers of said system;
further comprising an operations team who design, program, manage, control and update involved control systems;
wherein the versioning control system comprises versioning software and communication interfaces along with hardware implementing the same;
wherein the system is operable to produce multiple versions existing concurrently at locations which are remote relative to each other while being interactively viewed by both multiple independent users and other observers of said system;wherein each location of a subject experience is identical and all participants are deemed to have participated in a contemporaneous version of the involved real time physical reality immersive experience.

US Pat. No. 9,976,773

CONVECTION HEATER ASSEMBLY PROVIDING LAMINAR FLOW

GLEN DIMPLEX AMERICAS LIM...

1. A convection heater assembly to be located at a substantially vertical wall for heating air in a room at least partially defined by the wall, the convection heater assembly comprising:at least one elongate heating element to provide heat, said at least one heating element being positioned substantially horizontally and substantially parallel to the wall;
a plurality of heat transfer elements substantially vertically positioned on said at least one heating element, each said heat transfer element being spaced apart from an adjacent one of the heat transfer elements adjacent thereto for transferring heat therefrom to columns of the air moving substantially upwardly past the heat transfer elements;
each said heat transfer element being at least partially defined by top and bottom sides thereof and by inner and outer sides thereof positioned proximal to the wall and distal to the wall respectively;
the bottom side being located at least partially orthogonal to the wall, and inner and outer sides being located substantially parallel to the wall;
the inner side extending upwardly to an inner side tip at a top end of the inner side;
the outer side extending upwardly to an outer side tip at a top end of the outer side above the inner side tip;
the top side of each said heat transfer element extending between the inner wall tip and the outer wall tip;
the heat transfer elements adjacent to each other guiding an outer portion of the column of the air rising therebetween along an outer path proximal to the outer sides thereof, and guiding an inner portion of the column of air along an inner path proximal to the inner sides thereof;
the outer path being longer than the inner path, whereby more heat is transferred to the outer portion than to the inner portion from the heat transfer elements guiding the column of air as the column of air moves upwardly therebetween, to cause the outer portion to rise faster than the inner portion;
a housing at least partially defining a cavity therein in which said at least one heating element and the heat transfer elements positioned thereon are located, the housing comprising at least one inlet through which the air enters into the housing, and at least one outlet through which the columns of warmed air exit the housing; and
said at least one outlet being unobstructed for substantially vertical upwardly flow of the columns of warmed air from the heat transfer elements through said at least one outlet, permitting the cooler inner portion of each said column to be at least partially entrained by the warmer outer portion in each said column to provide substantially laminar flow of the columns of warmed air relative to the wall upon the columns exiting the convection heater assembly.

US Pat. No. 9,972,882

MULTI-MODE CAVITY FILTER AND EXCITATION DEVICE THEREFOR

MESAPLEXX PTY LTD., Quee...

1. A multi-mode cavity filter comprising:a first dielectric resonator body incorporating a first piece of dielectric material, the first piece of dielectric material having a shape supporting at least a first resonant mode and at least a second resonant mode substantially degenerate with the first resonant mode;
a second dielectric resonator body incorporating a second piece of dielectric material, the second piece of dielectric material having a shape supporting at least one resonant mode, said first dielectric resonator body adjoining said second dielectric resonator body at an interface therebetween, said interface having at least one edge;
an excitation device for at least one of:
establishing an electromagnetic field in said second dielectric resonator body external to, but immediately adjacent to, a face of the first dielectric resonator body, and
extracting energy from an electromagnetic field in said second dielectric resonator body located external to, but immediately adjacent to, a face of the first dielectric resonator body;
a layer of conductive material in contact with and covering the first and second dielectric resonator bodies, and extending over said interface between the first and second dielectric resonator bodies; and
at least one aperture in the layer of conductive material extending over said interface, said at least one aperture being for passing signals between the first dielectric resonator body and the second dielectric resonator body, said at least one aperture being adjacent to said at least one edge of said interface and not extending to a geometric center of said interface,
wherein the excitation device is located, in at least two dimensions, at a null in the electric field present close to, or on, the at least one face of the second dielectric resonator body for one or more modes having a higher order than said first and second resonant modes.

US Pat. No. 9,782,159

SURGICAL VISUALIZATION SYSTEMS

CAMPLEX, INC., Germantow...

1. A medical apparatus comprising:
a surgical microscope camera configured to acquire video images of a surgical site, the surgical microscope camera configured
to provide a surgical microscope view of the surgical site;

a surgeon viewing assembly comprising a surgeon display housing, at least one surgeon display within the surgeon display housing,
and surgeon binoculars configured to provide a view of the at least one surgeon display, the at least one surgeon display
being configured to provide images from the surgical microscope camera;

an assistant viewing assembly comprising an assistant display housing, at least one assistant display within the assistant
display housing, and assistant binoculars configured to provide a view of the at least one assistant display, the at least
one assistant display being configured to provide images from the surgical microscope camera; and

an image processing system configured to rotate images from the surgical microscope camera and provide the rotated images
to the at least one assistant display.

US Pat. No. 10,250,542

PROXIMITY DISCOVERY SYSTEM AND METHOD

PLEXUS MEET, INC., La Ha...

1. A proximity discovery system comprising:a server for storing contact data; and
a plurality of user devices comprising a first user device and a second user device;
each of the plurality of user devices comprising:
a) an antenna and transceiver for exchanging discovery messages with any one or more of a plurality of mobile devices;
b) a proximity detector for estimating a distance from the user device to any one or more of the other plurality of mobile devices;
c) a user detection module configured to:
i) generate discovery messages for any one or more of the other plurality of mobile devices; and
ii) detect the discovery messages from any one or more of the other plurality of mobile devices;
iii) wherein the discovery messages comprise information for identification of a human;
d) a connection module configured to:
i) transmit a first user profile; and
ii) receive a second user profile;
iii) wherein the user profile comprises biographic information; and
e) an alert generator configured to detect when a person previously determined by a user to be of interest has been detected.

US Pat. No. 9,876,572

CONFIGURING A COMPUTER NETWORK TO SATISFY MULTICAST DISPERSION AND LATENCY REQUIREMENTS USING AFFINITY AND NETWORK TOPOLOGIES

PLEXXI INC., Nashua, NH ...

1. A method for configuring a computer network having a plurality of network elements, the network elements including a plurality
of nodes interconnected by network links, the method comprising:
obtaining a network topology specifying a topology of the network elements and interconnections of the network elements by
the network links;

obtaining an affinity topology including a multicast dispersion descriptor requirement specifying a maximum acceptable difference
in arrival times of a multicast message transmitted by a first affinity element at at least two destination affinity elements;

computing an affinity-network topology that represents a logical combination of the network topology and the affinity topology
that satisfies the multicast dispersion descriptor requirement; and

configuring the plurality of nodes in accordance with the computed affinity-network topology so that the multicast message
transmitted by the first affinity element is received by the at least two destination affinity elements in satisfaction of
the multicast dispersion descriptor requirement.

US Pat. No. 9,843,083

MULTI-MODE FILTER HAVING A DIELECTRIC RESONATOR MOUNTED ON A CARRIER AND SURROUNDED BY A TRENCH

Mesaplexx PTY LTD, Queen...

1. An apparatus, comprising:
a carrier comprising one or more layers; and
a multi-mode filter formed on the carrier, comprising:
a dielectric resonator mounted on the carrier, the dielectric resonator having a covering of an electrically conductive material
in which there is provided an aperture; and

at least one coupling structure formed in the aperture for coupling input signals to the dielectric resonator or for extracting
filtered output signals from the dielectric resonator,

an enclosing formation of electrically conductive material provided as part of the carrier, where the enclosing formation
is electrically coupled to the electrically conductive covering of the dielectric resonator, such that the covering and the
enclosing formation together form an electrically conductive enclosure for the dielectric resonator, wherein the enclosing
formation comprises a continuous or almost continuous formation of grounded electrically conducting material and a trench
of electrically conductive material which surrounds the dielectric resonator and which resides in the one or more layers of
the carrier, the trench being electrically grounded.

US Pat. No. 9,595,302

HARD DISK DRIVE COVER WITH DIFFERENTIAL INNER AND OUTER SURFACE ROUGHNESS

INTRI-PLEX TECHNOLOGIES, ...

1. A hard disk drive cover made of a single piece of metal material for covering a hard disk drive base assembly, comprising:
an outer surface having a predetermined roughness average; and
an inner surface having a “BA” metal finish as defined by ASTM standard 480, chemically or mechanically treated to provide
a surface having a predetermined roughness average greater than or equal to 0.05 micrometers and less than or equal to 0.1
micrometers, the roughness average being less than the predetermined roughness average of the outer surface.

US Pat. No. 9,586,121

ADJUSTABLE GOLF DRIVING SURFACE ASSEMBLY

Sports Complex Design Gro...

1. A golf driving practice assembly, comprising:
a base, comprising:
a downwardly extending recess; and
an insert having first and second sides that is removably receivable in said recess of said base, said insert comprising:
a generally flat driving surface on said first side of said insert, that extends horizontally when said insert is received
within said recess of said base with said first side disposed upwardly; and

a generally sloped driving surface on said second side of said insert, that extends at an angle when said insert is received
within said recess of said base with said second side disposed upwardly.

US Pat. No. 10,584,122

SOLID FORMS OF A COMPOUND MODULATING KINASES

Plexxikon Inc., Berkeley...

1. A process of preparing a capsule comprising a crystalline form of Compound I:
which is Compound I Form C, characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 7.3, 23.3 and 28.2° 2? as determined on a diffractometer using Cu-Ka radiation, comprising combining Compound I Form C with a pharmaceutically acceptable carrier or excipient.

US Pat. No. 10,555,728

SURGICAL VISUALIZATION SYSTEM

CAMPLEX, INC., Germantow...

1. A method comprising:illuminating a surgical site via one or more light emitters;
receiving from at least one camera disposed on a retractor a first plurality of image data, said retractor configured to hold open an incision formed in a body thereby providing access to the surgical site;
receiving from at least one camera associated with a surgical tool a second plurality of image data;
processing the first plurality of image data to produce a first image;
processing the second plurality of image data to produce a second image, wherein the at least one camera disposed on the retractor or the at least one camera associated with the surgical tool or both the at least one camera disposed on the retractor and the at least one camera associated with the surgical tool comprises at least one stereo camera configured to provide stereo imagery; and
directing fluid to the one or more light emitters via a hydraulic system.

US Pat. No. 10,408,982

POLARIZING FILM, PREPARATION METHOD THEREOF, POLARIZING LENS COMPRISING THE SAME

TRIAPLEX CO., LTD., Hwas...

1. A polarizing lens comprising:a polarizing film; and
a urethane-based lens or a thiourethane-based lens,
wherein the polarizing film comprising
a transparent film substrate;
a first polyvinyl alcohol-based resin layer formed on one side of the transparent film substrate; and
a second polyvinyl alcohol-based resin layer formed on the other side of the transparent film substrate,
wherein at least one of the first and the second polyvinyl alcohol-based resin layers is a polarizing resin layer,
wherein the transparent film substrate and the first and the second polyvinyl alcohol-based resin layers are attached by an adhesive layer comprising a non-aqueous adhesive, an aqueous adhesive, or a mixture thereof, and
wherein one of the first and the second polyvinyl alcohol-based resin layers is directly adhered to the urethane-based lens or the thiourethane-based lens.

US Pat. No. 10,166,594

SPRING FORMING DEVICE, METHOD FOR FORMING A HELICAL SPRING AND CORRESPONDING COMPUTER PROGRAM

SIMPLEX RAPID S.R.L., Sa...

1. Spring forming device comprising:a system for feeding a wire for forming a helical spring;
a winding system suitable for winding said wire according to a helical configuration having a predefined diameter (D) extending along a helix development axis (A);
one or more pitch tools, each adapted to act on wire such that it takes on said cylindrical helix configuration with a predetermined pitch (p);
a system for detecting an actual pitch (peff) of the spring forming in the device starting from said wire and
a control unit comprising means for detecting an amount (I) of the fed wire;
said control unit is configured to:
determine an actual length (Leff) of the spring forming in the device, based on the actual fed wire amount (I) and pitch (peff) detected for spring portions already formed in the device;
determine a reference length (L) as a function of said actual amount (I) of fed wire;
determine an error between said reference length (L) and said actual length (Leff); and
generate a command signal such that, during spring formation, the configuration of one of said one or more pitch tools is varied as a function of said error.

US Pat. No. 9,896,394

METHOD FOR IMPROVING PROPANE DEHYDROGENATION PROCESS

National Industrializatio...

1. A method for purifying propylene obtained from a propane dehydrogenation process by converting dehydrogenation by-products
comprising:receiving a hydrogen-free first hydrocarbon stream comprising methyl acetylene, propadiene, butadiene, propane and propylene
from a propane dehydrogenation process;at least one step of heating and pressurizing the first hydrocarbon stream;contacting the first hydrocarbon stream with a first catalyst in the presence of injected hydrogen to at least partially hydrogenate
methyl acetylene and propadiene and form a second hydrocarbon stream;contacting the second hydrocarbon stream with a second catalyst to complete the hydrogenation of methyl acetylene and propadiene,
and removing at least a portion of residual hydrogen to form a third hydrocarbon stream comprising propane and propylene in
an amount of 99.0-99.99% w/w and less than 0.000001% w/w of methyl acetylene, propadiene, butadiene and hydrogen; andcontacting the third hydrocarbon stream with a third catalyst which catalyzes removal of residual hydrogen from the third
hydrocarbon stream at a level of less than 0.000001% w/w to form a hydrogen-free third hydrocarbon stream;wherein
the first catalyst has a selectivity towards hydrogenation of methyl acetylene and propadiene to propylene of at least 85%
w/w and a surface area of 70-120 m2/g; and

each of the second and the third catalysts has a selectivity towards hydrogenation of methyl acetylene and propadiene to propylene
of no more than 75% w/w and a surface area of 50-90 m2/g;
wherein the first catalyst is located in a first catalyst bed, the second catalyst is located in a second catalyst bed and
downstream of the first catalyst bed, and the third catalyst is located in a third catalyst bed and downstream of the second
catalyst bed, andwherein the hydrogen-free third hydrocarbon stream comprises propane and propylene in an amount of 99.0-99.99% w/w and less
than 0.000001% w/w hydrogen, methyl acetylene, propadiene, and butadiene.

US Pat. No. 9,887,777

AFFINITY MODELING IN A DATA CENTER NETWORK

Plexxi Inc., Nashua, NH ...

1. A method for configuring a computer network having a plurality of network elements, the network elements including a plurality
of nodes interconnected by network links, the method comprising:
obtaining a network topology specifying a topology of the network elements and interconnections by the network elements;
obtaining an affinity topology that includes at least one predefined affinity descriptor requirement pertaining to communications
between first and second affinity elements of respective first and second affinity groups, wherein each affinity group includes
an affinity port and wherein the first and second affinity elements correspond to first and second application components
that communicate therebetween over at least one affinity link, the at least one predefined affinity descriptor requirement
being at least one of:

i) a total number of single points of failure in the network involving the communications between the first and second affinity
groups upon the occurrence of which the affinity ports for communication between the first and second affinity groups are
disconnected;

ii) a limitation on oversubscription of a network element in a path between the first and second affinity groups;
iii) a requirement for isolation of at least one of:
(a) predetermined communications originating from one or more network elements from utilization of the at least one affinity
link; or

(b) a physical machine hosting the first application component from hosting a third distinct application component;
iv) a maximum hop count limitation for communications between affinity ports in the first and second affinity groups; and
v) a specification pertaining to latency for communications between the first affinity element in the first affinity group
and the second affinity element in the second affinity group; computing an affinity-network topology that represents a logical
combination of the network topology and the affinity topology that satisfies the at least one predefined affinity descriptor
requirement; and

configuring the plurality of nodes in accordance with the computed affinity-network topology so that a communication between
the first affinity element and the second affinity element satisfies the at least one predefined affinity descriptor requirement.

US Pat. No. 9,699,530

OPTICAL ARCHITECTURE AND CHANNEL PLAN EMPLOYING MULTI-FIBER CONFIGURATIONS FOR DATA CENTER NETWORK SWITCHING

PLEXXI INC., Nashua, NH ...

1. A method of routing a multicast frame in an optical network having a plurality of communicably interconnected optical nodes
including a multicast master node and a plurality of slave nodes, the method comprising the steps of:
receiving, at a first slave node which is one of the plurality of slave nodes in the optical network, a multicast frame transmitted
as a first optical signal over the optical network from the multicast master node;

converting, at an optical to electrical converter associated with the first slave node, the received first optical signal
to an electrical signal corresponding to the received multicast frame;

receiving, at a first circuit switch input of a circuit switch associated with the first slave node, the electrical signal
from the optical to electrical converter in unmodified form, the circuit switch further having a second circuit switch input
and first and second circuit switch outputs, the circuit switch being connected to a packet switch associated with the first
slave node, the packet switch having a packet switch input and a packet switch output, the second circuit switch input being
coupled to the packet switch output and the second circuit switch output being coupled to the packet switch input;

forwarding the electrical signal, with low latency, directly through the circuit switch to the first circuit switch output
so as to bypass the packet switch;

receiving, at an input of an electrical to optical converter associated with the first slave node, the electrical signal from
the first circuit switch output;

converting, at the electrical to optical converter, the electrical signal to a second optical signal corresponding to the
received multicast frame;

transmitting the received multicast frame from a first optical output of the first slave node as the second optical signal
downstream on the optical network for receipt by another optical node in the optical network; and

forwarding the received multicast frame to an external computerized device coupled to the first slave node in the event that
the external computerized device is a multicast subscriber, wherein the received multicast frame is forwarded to the external
computerized device using one of: a path from the circuit switch through the packet switch to the external computerized device,
and a path directly from the circuit switch to the external computerized device so as to bypass the packet switch.

US Pat. No. 9,587,138

CROSSLINKABLE COMPOSITION

NUPLEX RESINS B.V., Berg...

1. An RMA crosslinkable composition for making thick coating layers comprising reactive components A and B each comprising
at least 2 reactive groups wherein the at least 2 reactive groups of component A are RMA donor group being C—H acidic protons
in activated methylene or methine groups, and the at least 2 reactive groups of component B are RMA acceptor group being activated
C?C unsaturated groups, to achieve crosslinking by Real Michael Addition reaction, said composition further comprising a base
catalyst C, an X—H group containing component D, of a nature different from A, that is also a Michael addition donor reactable
with component B under the action of base catalyst C, wherein X is C, N, P, O or S and a sag control component E, wherein
the X—H group of component D being characterized by a pKa, defined in aqueous environment, of at least one unit, less than
that of the dominant type of C—H groups in component A.

US Pat. No. 10,464,104

METHOD FOR VERIFYING OPERATIVE PARAMETERS OF A SELECTING DEVICE OF A SPRING FORMING MACHINE, AND SPRING FORMING MACHINE

SIMPLEX RAPID S.R.L., (I...

1. A method for verifying operative parameters of a selecting device of a machine for forming springs, configured for subdividing the springs formed by a spring forming device of a spring forming machine into at least one first group, corresponding to springs having dimensional parameters falling into predefined tolerance values, and a second group, corresponding to springs having dimensional parameters varying from said predefined tolerance values, said method comprising:setting the spring forming device such that it makes a test run of springs comprising a predetermined number of faulty springs having dimensional parameters varying from said predefined tolerance values, and a predetermined number of suitable springs having dimensional parameters falling into said predefined tolerance values;
detecting the dimensional parameters of each spring formed in the spring forming device by a measuring system of the machine;
subdividing, by said selecting device, the springs formed by the spring forming device into said at least one first and said second group;
verifying the absence of suitable springs among the springs selected by the selecting device in the second group; and
comparing the number of the faulty springs selected by the selecting device in the second group with said predetermined number of faulty springs set of the test run.

US Pat. No. 10,312,839

BRUSHLESS DC MOTOR WITH CONTROL ELECTRONICS MOTOR ASSEMBLY

SIMPLEX MOTION AB, Gothe...

1. A motor assembly, comprising:a brushless DC motor with an external rotor and an internal stator;
a plurality of permanent magnets disposed upon an inside of a cylindrical periphery of the external rotor, the permanent magnets providing magnetic poles;
a printed circuit board provided with control electronics comprising a microprocessor; the printed circuit board is planar and is oriented tangentially to the cylindrical periphery of the external rotor, mounted within a housing with the brushless DC motor;
at least two magnetic field sensors positioned to sense a magnetic flux of the magnetic poles through the cylindrical periphery of the external rotor, the magnetic field sensors mounted upon the printed circuit board.

US Pat. No. 10,303,783

DISTRIBUTED VIRTUAL STORAGE OF PORTABLE MEDIA FILES

Callplex, Inc., St. Pete...

1. A method of inherently securing files for distributed storage across a plurality of storage devices, wherein one or more processors execute a plurality of computer executable instructions stored on a tangible, non-transitory computer storage medium for performing the method, said method comprising:determining whether the one or more processors can access a local storage device;
in response to determining the one or more processors cannot access the local storage device, terminating said method; and
in response to determining the one or more processors can access the local storage device:
determining a number of portions in which a file will be stored based on a predetermined maximum portion length as a function of a packet size of the local storage device connected to the one or more processors and the tangible, non-transitory computer storage medium;
calculating a portion length for each of the portions based on a set of length constraints that define an interrelationship between the portions based on their respective lengths;
partitioning the file into the determined number of portions according to the calculated portion length of each portion, each partitioned portion having a content, said partitioned portions including a terminal portion;
performing one or more logical operations between the content of each partitioned portion and the content of at least one other partitioned portion, said performance of logical operations starting at a first bit of the content of each partitioned portion and proceeding bitwise to subsequent bits of the content along the length of each partitioned portion;
modifying each partitioned portion by replacing the content thereof with results of said logical operations;
assigning a unique name to each modified portion other than the terminal portion, said unique name of each modified portion indicative of the content of at least one other modified portion;
storing the terminal portion on the local storage device; and
transferring all other modified portions to a remote storage through a communication network, wherein the remote storage is other than the local storage device.

US Pat. No. 10,247,729

MEDIA ELABORATED WITH NEWLY SYNTHESIZED ANTIBODIES (MENSA) AND USES THEREOF

MICROBPLEX, INC., Atlant...

4. A method of producing an analytical matrix comprising MENSA the method comprising obtaining whole blood or PBMC from a subject separating plasma from the whole blood or PBMC to produce separated cells; isolating newly proliferated ASC from the separated cells; washing the newly proliferated ASC; and incubating the washed newly proliferated ASC in a media that supports maintenance of ASC and antibody secretion to thereby produce the MENSA; wherein the the analytical matrix comprises at least a 106 or 107-fold reduction of contaminating pre-existing plasma antibodies relative to whole blood, plasma, or PBMC.

US Pat. No. 10,099,846

EGG CARTON WITH MATING CELL AND LID POST STRUCTURE

Tekni-Plex, Inc., Wayne,...

1. A method of stacking a plurality of plastic egg cartons on top of one another, each egg carton having a tray and a lid hingedly connected to the tray for pivoting between open and closed positions, the tray and the lid having respective peripheral edges that mate with each other in the closed position, the egg carton having in the closed position a length, a width and a height;the tray having a plurality of cells for receiving individual eggs, the cells being arranged successively adjacent each other along the length and width of the carton;
each cell having a bottom and a sidewall extending upwardly from the bottom to form a corresponding one of the cells;
the tray having a plurality of cell posts, extending upwardly toward the lid above the peripheral edge of the tray, each cell post having a central axis aligned with the height of the carton and being formed at an intersection of four adjacent cells as an extension of the sidewalls of the four adjacent cells;
each cell post having four generally planar ramp surfaces, one disposed respectively on each of the four sidewall extensions between the sidewalls of two adjacent cells, the planar ramp surfaces being aligned at an angle of from about 20 to about 45 degrees relative to the central axis of the cell post; and,
the lid having a plurality of lid posts, wherein the cell posts and lid posts are configured to hold each egg axially aligned with the central axis, each lid post extending downwardly toward the tray and including complementary planar ramp surfaces for mating with the planar ramp surfaces of the cell post when the lid is in the closed position and wherein each lid post includes four downwardly extending figners, each finger having one of the complementary planar ramp surfaces,
the method comprising steps of:
filling the cells of each egg carton with eggs axially aligned with the central axis of its respective cell,
closing the lids, and
stacking the filled closed egg cartons on top of one another.

US Pat. No. 9,942,623

DATA CENTER NETWORK ARCHITECTURE

PLEXXI INC., Nashua, NH ...

1. Computer network configuration apparatus for use in a network including a plurality of network nodes interconnected by one or more network segments and a plurality of computers communicably coupled to selected ones of the plurality of network nodes, wherein the plurality of computers are operative to execute application programs thereon, the computer network configuration apparatus comprising:a plurality of local controllers, each of the local controllers associated with a corresponding network node having an associated memory containing a same plurality of end-to-end forwarding topologies identifying one or more network segments for forwarding traffic through the network; and
wherein each local controller is configured to, independently of all other local controllers:
deterministically select and utilize at least one of the plurality of end-to-end forwarding topologies as an initial forwarding topology and to maintain a non-selected one of the plurality of end-to-end forwarding topologies as an alternative forwarding topology, and
in response to a change in a current network state, deselect the initial forwarding topology and independently and deterministically select and utilize the alternative forwarding topology in place of the initial forwarding topology,
wherein each local controller is configured to select the same end-to-end forwarding topology as the initial forwarding topology and to select the same alternative end-to-end forwarding topology in response to the change in the current network state.

US Pat. No. 9,729,854

SYSTEM AND METHOD FOR SCANNING A SPECIMEN TO CREATE A MULTIDIMENSIONAL SCAN

Innova Plex, Inc., Sugar...

1. A method for scanning a specimen to create a multi-dimensional scan comprising the steps of
illuminating a specimen with a light, said specimen comprising a topography, the depths of said topography variable along
a z-axis;

dividing said specimen into a plurality of regions, each of said regions comprising a minimum depth and a maximum depth, said
topography between said minimum depth and said maximum depth;

sampling each of said regions at a plurality of focal planes orthogonal to said z-axis by capturing, at each focal plane,
an image of said region, said image focused on said focal plane, and

stitching together said images within common focal planes into a dimensional image for each of said focal planes.
US Pat. No. 9,663,444

HETEROATOM CONTAINING SUBSTITUTED FATTY ACIDS

Complexa, Inc., Radnor, ...

1. An activated fatty acid comprising a hydrochloride salt of an unsaturated or polyunsaturated aliphatic chain having at
least one electron withdrawing group positioned immediately adjacent to a carbon-carbon double bond wherein two or more carbon-carbon
double bonds are conjugated; wherein the at least one electron withdrawing group is selected from the group consisting of
a vinyl group, an allylic group, or an allyl fluoride (—CH?CHCH2F) group.

US Pat. No. 9,155,200

PLANAR CONTACT WITH SOLDER

Interplex Industries, Inc...

1. A method of fixing reflowable elements on electrical contacts, the method comprising:
providing a strip including a plurality of electrical contacts, each contact including a contact body and a tail portion extending
away from the contact body;

disposing each tail portion of the plurality of electrical contacts adjacent an elongate reflowable member;
moving the elongate reflowable member with respect to the contacts, such that at least a part of each tail portion is inserted
into the reflowable member;

cutting the elongate reflowable member into a plurality of separate reflowable elements, each reflowable element corresponding
to a respective tail portion; and

separating the electrical contacts from the strip.

US Pat. No. 10,436,776

METHODS AND SYSTEMS FOR SELECTION OF DETECTION AREA

PLEXBIO CO., LTD., Taipe...

1. A system comprising:an objective, a camera, a light source, a detection stage, one or more processors, a memory, and one or more programs stored in the memory, wherein the one or more programs are configured to be executed by the one or more processors, and wherein the one or more programs include instructions for:
obtaining data representing one or more images of a well of an assay plate positioned on the detection stage, wherein the well comprises a plurality of encoded microcarriers, wherein the plurality of encoded microcarriers comprises (i) a first subset of one or more encoded microcarriers, wherein each microcarrier of the first subset comprises a first code and a first capture agent that specifically recognizes a first analyte; and (ii) a second subset of one or more encoded microcarriers, wherein each microcarrier of the second subset comprises a second code and a second capture agent, wherein the second code is different from the first code, and wherein the data representing the one or more images of the well are obtained by the camera using the objective and the light source;
calculating a center of the well, according to a two-dimensional coordinate system, based on the obtained data;
assigning a position, according to the two-dimensional coordinate system, of a first encoded microcarrier from the plurality of encoded microcarriers based on the obtained data;
determining whether a distance between the position of the first encoded microcarrier and the center of the well according to the two-dimensional coordinate system exceeds a threshold distance;
in accordance with a determination that the distance between the position of the first encoded microcarrier and the center of the well exceeds the threshold distance:
excluding the first encoded microcarrier from a detection area; and
in accordance with a determination that the distance between the position of the first encoded microcarrier and the center of the well does not exceed the threshold distance:
including the first encoded microcarrier in the detection area, thereby selecting the detection area.

US Pat. No. 10,369,392

AERIAL FIRE SUPPRESSION SYSTEM

Simplex Manufacturing Co....

1. A fire suppression apparatus for fighting fires from a helicopter, comprising:a water tank for housing water, the water tank configured for attachment to the helicopter;
a foam tank for housing a foam, the foam tank housed inside the water tank, wherein the water tank is configured to receive the foam from the foam tank that when mixed with the water in the water tank forms a batch of a liquid fire retardant in the water tank, and
a centrifugal pump supportable by the helicopter, the pump including a radial outflow impeller and driven by an electric motor, the pump including an air induction valve with an electrically variable valve opening disposed at and connected to a suction end of the pump so as to form an air inlet, wherein air and the fire retardant are drawn into the suction end and pressurized by the pump for discharge toward a target.