US Pat. No. 9,053,913

POSITIONING GUIDES AND ION SOURCES

PerkinElmer Health Scienc...

11. An ion source insert device comprising an integral positioning guide configured to permit positioning of a chromatography
column underneath the positioning guide, the positioning guide further configured to magnify space underneath the positioning
guide.

US Pat. No. 9,504,137

CAPACITIVELY COUPLED DEVICES AND OSCILLATORS

PerkinElmer Health Scienc...

1. A device comprising:
a torch; and
a capacitive device external to and around at least a portion of the torch and contacting an outer surface of the torch, the
capacitive device configured to provide radio frequency energy to the torch to sustain a capacitively coupled plasma in the
torch, wherein the capacitive device comprises a wire coil external to and coiled around the torch, in which the wire coil
is configured to couple to an oscillator at a first end of the wire coil and configured to contact an outer surface of the
torch at a second terminal end of the wire coil to provide capacitive coupling to the torch.

US Pat. No. 9,488,638

TRITIATED PLANAR CARBON FORMS

PerkinElmer Health Scienc...

1. A method for producing a tritiated planar carbon form comprising:
reacting a planar carbon form comprising one or more carboxylic acid groups on a surface of said planar carbon form, with
a reducing agent capable of reducing a carboxylic acid so as to produce a tritiated planar carbon form with at least one atom
of tritium associated with said surface.

US Pat. No. 9,420,679

HYBRID GENERATORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A system comprising:
an induction device; and
a generator electrically coupled to the induction device and configured to provide power to the induction device to sustain
an inductively coupled plasma in a torch portion received by the induction device, the generator comprising a circuit configured
to electrically couple to the induction device and provide power to the induction device in a driven mode to sustain the inductively
coupled plasma in the torch body in the driven mode and configured to provide power to the induction device in an oscillation
mode to sustain the inductively coupled plasma in the torch body in the oscillation mode.

US Pat. No. 9,117,641

DIRECT SAMPLE ANALYSIS DEVICE ADAPTERS AND METHODS OF USING THEM

PERKINELMER HEALTH SCIENC...

1. An adapter for installing a direct sample analysis device on a mass spectrometer, the adapter comprising:
a capillary sleeve configured to couple to a capillary inlet of the mass spectrometer, in which the capillary sleeve is configured
to couple to the capillary inlet through a friction fit between outer surfaces of the capillary inlet and inner surfaces of
the capillary sleeve; and

an end cap extension configured to couple to the capillary sleeve, in which the capillary sleeve and end cap extension are
configured to provide fluidic coupling between a sample holder of the direct sample analysis device and the mass spectrometer
through the capillary inlet.

US Pat. No. 9,146,233

DETECTING MOLECULAR INTERACTIONS BY FLUORESCENCE RESONANCE ENERGY TRANSFER ON A SOLID-PHASE SUPPORT

PerkinElmer Health Scienc...

1. A composition comprising:
a first solid-phase support comprising a target-selective binding agent and a first member of a Fluorescence Resonance Energy
Transfer (FRET) pair; and

a target molecule associated with a second member of the FRET pair, wherein the target molecule is not associated with a solid-phase
support;

wherein the first solid-phase support comprises phthalocyanine and thioxene;
wherein the first member of the FRET pair is a lanthanide chelate; and
wherein the target-selective binding agent comprises deferoxamine-Fe3+ and preferentially binds to a target molecule that comprises a phosphomonoester moiety as compared to a target molecule that
does not comprise a phosphomonoester moiety.

US Pat. No. 9,343,280

MULTI-PRESSURE STAGE MASS SPECTROMETER AND METHODS

PerkinElmer Health Scienc...

1. A mass spectrometer, comprising:
a plurality of guide stages for guiding ions between an ion source and an ion detector along a guide axis;
an ion interface for guiding a transport gas and ions entrained therein, said ion interface comprising a casing having a sampling
inlet in flow communication with an ion source that ionizes particles of interest and an outlet in communication with a first
one of said plurality of guide stages and that slows said transport gas to a generally laminar flow in a laminar flow region;

each of said guide stages contained within one of a plurality of adjacent chambers;
said ion interface and said guide stages defining a continuous flow path from said ion source to said ion detector, for guiding
said transport gas and ions entrained therein from said ion source by way of said sampling inlet to said ion detector and
wherein said transport gas is provided from said laminar flow region to said guide stages;

at least one pump in flow communication with said plurality of chambers to establish a pressure regime in said plurality of
chambers, and along said guide axis

in which pressure in each of said plurality of chambers is reduced downstream along said guide axis, and the pressure between
said ion interface and a first one of said plurality of chambers differs at a location in said first one of said plurality
of chambers by about an order of magnitude, and the pressure at a location in said first one of said plurality of chambers
differs from the pressure at a location in a second one of said plurality of chambers by about an order of magnitude, and
wherein said pressure regime provides a non-abrupt pressure gradient along said guide axis, to smoothly guide ions entrained
in said transport gas along said guide axis from stage to stage of said plurality of guide stages.

US Pat. No. 9,105,457

CONE-SHAPED ORIFICE ARRANGEMENT FOR INDUCTIVELY COUPLED PLASMA SAMPLE INTRODUCTION SYSTEM

PerkinElmer Health Scienc...

1. A mass analysis system comprising:
an inductively coupled plasma and a sample introduction system arranged to ionize a portion of a sample into ions,
a sampler element including a first orifice arranged to receive the ions into a first vacuum chamber,
a first skimmer element having an ungrounded electrical bias and including a second orifice arranged to pass the ions from
the first vacuum chamber into a second vacuum chamber, and

a second skimmer element including a third orifice arranged to pass the ions from the second vacuum chamber into a third vacuum
chamber, the third vacuum chamber including an ion optics assembly for passing the ions to a mass analyzer comprising a quadrupole
mass spectrometer, the third orifice being configured to allow a continuum flow of ions to the mass analyzer, wherein the
second skimmer element is biased at about ground potential to shield the first skimmer element from downstream extraction
fields, wherein the third orifice and second orifice are aligned along a same axis, the diameter of the third orifice being
greater than or equal to the diameter of the second orifice.

US Pat. No. 9,565,747

ASYMMETRIC INDUCTION DEVICES AND SYSTEMS AND METHODS USING THEM

PerkinElmer Health Scienc...

1. A system comprising:
a torch body; and
an induction device comprising a plurality of asymmetrically spaced induction coils configured to receive a portion of the
torch body to sustain an atomization source in the torch body, in which the asymmetrically spaced induction coils are coupled
to each other and form an aperture to receive the portion of the torch body and in which longitudinal spacing, along a longitudinal
direction of the torch body, between at least three coils of the plurality of induction coils is asymmetric.

US Pat. No. 9,516,735

TORCHES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A torch comprising an outer tube configured to sustain an atomization source in the outer tube, the torch outer tube comprising
an inlet end within a first section of the torch outer tube and an exit end within a second section of the torch outer tube,
in which the torch is configured to desolvate sample at the first section of the torch outer tube and to sustain an atomization
source within the second section of the torch outer tube, in which the first section and the second section of the torch outer
tube are coupled to each other through at least one material, in which the first section of the torch outer tube comprises
a non-refractory material, and in which the exit end of the outer tube comprises at least one lanthanide or actinide material,
and in which the material coupling the first section and the second section is different than the non-refractory material
of the first section and the at least one lanthanide or actinide material of the exit end of the outer tube.

US Pat. No. 9,449,803

MASS SPECTROMETER INTERFACE

PERKINELMER HEALTH SCIENC...

1. A method of providing ionized particles of a sample to a mass spectrometer, comprising:
introducing a mixture of gas and said ionized particles from a source of high pressure into an inlet of a channel;
maintaining said channel at a pressure below atmosphere;
expanding said mixture into said channel;
introducing at least one of a) a reagent; b) a second mixture of ionized particles and attached impurities; or c) electrons,
to interact with said ionized particles in said channel and further aid in ionization of said sample;

slowing said gas within said channel to provide a substantially laminar flow proximate an exit of said channel; and
sampling said ionized particles proximate said exit, for analysis in said mass spectrometer.

US Pat. No. 9,423,383

CHROMATOGRAPHY SYSTEMS AND METHODS USING THEM

PerkinElmer Health Scienc...

16. A method comprising:
selecting a fluid flow rate to be used in a chromatography system;
determining a dimension of a restrictor in the chromatography system to provide the selected fluid flow rate and
configuring the chromatography system with a switching valve upstream of the restrictor, the switching valve configured to
actuate between a first position and a second position, the first position permitting fluid flow from a modulating gas source
to a first charging chamber of a microfluidic device to provide column effluent from the first charging chamber to a detector
fluidically coupled to the microfluidic device, and the second position permitting fluid flow from the modulating gas source
to the second charging chamber of the microfluidic device to provide column effluent from the second charging chamber to the
detector fluidically coupled to the microfluidic device.

US Pat. No. 9,186,613

SORBENT DEVICES AND METHODS OF USING THEM

PERKINELMER HEALTH SCIENC...

14. A method comprising:
exposing a sorbent device to an environment comprising volatile species to permit the volatile species to adsorb to the sorbent
device, the sorbent device comprising a plurality of different sorbent materials, in which the sorbent materials are arranged
from a material with a weakest sorbent strength to a material with a strongest sorbent strength, according to their relative
ability to adsorb species, with the weakest sorbent strength material adjacent to a sampling inlet of the sorbent device,
in which the sorbent device comprises at least three graphitized carbon black sorbent materials; and

desorbing the species adsorbed to the sorbent device by heating the sorbent device in a single desorption cycle to desorb
substantially all adsorbed species in the sorbent device.

US Pat. No. 9,433,073

INDUCTION DEVICES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A device for sustaining an ionization source in a torch comprising a longitudinal axis along which a flow of gas is introduced
during operation of the torch, the device comprising:
a base configured to provide a coil comprising a first turn and a second turn to provide an inner aperture formed from the
first and second turns of the coil, in which the inner aperture is constructed and arranged to receive a body of the torch;
and

a first radial fin coupled to the first turn of the coil and a second radial fin coupled to the second turn of the coil, in
which the coil is configured to provide radio frequency energy to the body of the torch to sustain the ionization source within
the torch; and

a spacer coupled to the first radial fin of the first turn of the coil and to the second radial fin of the second turn of
the coil.

US Pat. No. 9,297,909

GUARD EFFICIENCY COMPENSATION SYSTEM AND METHOD

PERKINELMER HEALTH SCIENC...

1. A radiation detection system comprising:
a scintillator configured to detect sample events associated with an unknown sample;
a guard detector subsystem configured to detect active guard events;
one or more processors adapted to:
count coincident events that are the sample events and the active guard events detected coincidently in one or more energy
regions and count non-coincident events that are the sample events detected when the active guard events are not coincidently
detected; and

for each energy region
calculate a compensation guard count based on the count of coincident events and a predetermined guard efficiency value associated
with the energy region,

calculate a correction value that is based on the compensation guard count and the counts of coincident events and the count
of non-coincident events, and

correct the count of non-coincident events corresponding to the energy region based on the calculated correction value to
produce corrected sample event counts.

US Pat. No. 9,635,750

OSCILLATOR GENERATORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A generator configured to sustain an inductively coupled plasma in a torch body, the generator comprising a processor and
an oscillation circuit electrically coupled to the processor, the oscillation circuit configured to electrically couple to
an induction device and provide power to the induction device in an oscillation mode to sustain the inductively coupled plasma
in the torch body, the circuit configured to provide harmonic emission control during sustaining of the inductively coupled
plasma in the torch body in the oscillation mode of the generator.

US Pat. No. 9,283,557

LAB MEMBERS AND LIQUID HANDLING SYSTEMS AND METHODS INCLUDING SAME

PerkinElmer Health Scienc...

1. A laboratory liquid handling system comprising:
a pipetting module including a pipettor, the pipettor including a pipettor shaft and a pipetting tip extending from an end
of the pipettor shaft;

a lab member including a body and at least one adapter structure including an interlock feature configured to laterally receive
and interlock with the pipettor shaft to releasably secure the lab member to the pipettor shaft; and

a drive system including a controller programmed with instructions to:
selectively move the pipettor shaft laterally relative to the interlock structure to engage the pipettor shaft with the interlock
structure to secure the lab member to the pipetting module;

move the pipetting module to transport the lab member secured thereto; and
selectively move the pipettor shaft laterally relative to the interlock structure to disengage the pipettor shaft from the
interlock structure to thereby release the lab member from the pipetting module.

US Pat. No. 9,127,307

REAGENTS AND METHODS RELATING TO DNA ASSAYS USING AMPLICON PROBES ON ENCODED PARTICLES

PerkinElmer Health Scienc...

1. A reagent for assaying DNA, comprising:
a plurality of synthetic encoded particles having attached amplicons amplified from a template DNA sequence, wherein each
individual synthetic encoded particle of the plurality of synthetic encoded particles comprises multiple different attached
amplicons, wherein each individual attached amplicon comprises a DNA sequence identical to a random portion of the template
DNA sequence, wherein the attached amplicons together represent substantially the entire template DNA and wherein the DNA
sequence identical to a random portion of the template DNA sequence of each individual attached amplicon is shorter than the
entire template DNA sequence.

US Pat. No. 9,129,790

ORTHOGONAL ACCELERATION TOF WITH ION GUIDE MODE

PerkinElmer Health Scienc...

1. A system, comprising:
an electronic controller; and
a time-of-flight mass analyzer in communication with the electronic controller, the time-of-flight mass analyzer comprising:
a pulsing region defining a channel that extends along an axis, the pulsing region comprising:
a first electrode extending along the axis, the first electrode defining one or more apertures;
a second electrode extending along the axis, the first and second electrodes being positioned on opposing sides of the axis
in a first direction perpendicular to the axis;

a third electrode extending along the axis; and
a fourth electrode extending along the axis, the third and fourth electrodes being positioned on opposing sides of a plane
defined by the axis and the first direction,

wherein:
the electronic controller is programmed to apply a first set of voltages to the electrodes to constrain a motion of ions propagating
along the axis in a radial direction relative to the axis, and apply a second set of voltages to the electrodes to accelerate
the ions out of the pulsing region through the one or more apertures, where the first set of voltages comprises RF voltages
applied to the first and second electrodes, the RF voltages being in phase with each other.

US Pat. No. 9,267,928

LAMP TEMPERATURE MANAGEMENT SYSTEMS AND METHODS FOR LIQUID CHROMATOGRAPHY ANALYZERS

PerkinElmer Health Scienc...

1. A liquid sample analyzer comprising:
a flow cell configured to receive a flow of a liquid sample from a liquid sample source;
a light source including a lamp configured to emit light to illuminate the flow of the liquid sample in the flow cell; and
a lamp temperature management system including:
an air flow generator operable to generate a turbulent air flow to cool the lamp;
a thermally conductive primary housing encapsulating the lamp such that a primary air gap is provided between the primary
housing and the lamp; and

a thermally conductive secondary housing surrounding the primary housing and configured to deflect the turbulent air flow
away from the primary housing;

wherein:
a buffer chamber is defined by and between the primary housing and the secondary housing;
the primary housing defines a lamp chamber containing the lamp; and
the lamp chamber is fluidly sealed from the buffer chamber.

US Pat. No. 9,263,243

ASSEMBLIES FOR ION AND ELECTRON SOURCES AND METHODS OF USE

PerkinElmer Health Scienc...

1. A mass spectrometer comprising:
a housing configured to receive a source and comprising a first integral alignment feature;
a terminal lens coupled to the housing and constructed and arranged to provide a beam, the terminal lens comprising a second
integral alignment feature, the terminal lens constructed and arranged to couple to the housing when the first integral alignment
feature is coupled to the second integral alignment feature to align the terminal lens with the source components in the housing
and retain source components in the housing to provide a source assembly; and

a mass analyzer coupled to the terminal lens.

US Pat. No. 9,091,629

FLOW CELL MODULES AND LIQUID SAMPLE ANALYZERS AND METHODS INCLUDING SAME

PerkinElmer Health Scienc...

1. A flow cell module for use in a liquid sample analyzer, the liquid sample analyzer including a radiation source, a sensing
device and a liquid sample source, the flow cell module comprising:
a module housing;
a liquid core waveguide mounted in the module housing and configured to receive a flow of a liquid sample from the liquid
sample source;

an input optical fiber disposed in the module housing and configured to transmit radiation from the radiation source to the
liquid core waveguide;

an input termination on an input end of the input optical fiber;
a first kinematic connection mechanism operative to bias the input termination relative to the module housing in a first direction
along a first axis while permitting displacement of the input termination with a limited deflection distance relative to the
module housing in a first opposing direction along the first axis; and

a second kinematic connection mechanism operative to bias the input termination relative to the module housing in a second
direction along a second axis while permitting displacement of the input termination relative to the module housing in a second
opposing direction along the second axis, wherein the second axis is transverse to the first axis.

US Pat. No. 9,073,052

LAB MEMBERS AND LIQUID HANDLING SYSTEMS AND METHODS INCLUDING SAME

PerkinElmer Health Scienc...

1. A laboratory liquid handling system comprising:
a pipetting module including a pipettor, the pipettor including a pipettor shaft and a pipetting tip extending from an end
of the pipettor shaft;

a lab member including a body and at least one adapter structure including an interlock feature configured to laterally receive
and interlock with the pipettor shaft to releasably secure the lab member to the pipettor shaft; and

a drive system including a motor and a controller operative to control the motor to:
selectively move the pipettor shaft laterally relative to the interlock structure to engage the pipettor shaft with the interlock
structure to secure the lab member to the pipetting module;

move the pipetting module to transport the lab member secured thereto; and
selectively move the pipettor shaft laterally relative to the interlock structure to disengage the pipettor shaft from the
interlock structure to thereby release the lab member from the pipetting module;

wherein:
the pipetting module includes a second pipettor including a second pipettor shaft and a second pipetting tip extending from
an end of the second pipettor shaft;

the at least one adaptor structure includes a second interlock feature configured to laterally receive and interlock with
the second pipettor shaft to releasably secure the lab member to the second pipettor shaft;

the first interlock structure includes a first substantially U-shaped support flange defining a first flange slot and a first
lateral opening in communication with the first flange slot;

the second interlock structure includes a second substantially U-shaped support flange defining a second flange slot and a
second lateral opening in communication with the second flange slot; and

the first and second support flanges are opposingly arranged such that the first and second lateral openings face one another.

US Pat. No. 9,384,954

TIME OF FLIGHT TUBES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A time of flight tube comprising:
an inner tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside
the inner tube, the inner tube comprising a conductive metal material disposed on an inner surface of the inner tube, the
conductive metal material present in an effective amount to provide a field free region for ions when the conductive material
is charged from a current applied to the conductive metal material;

an outer tube surrounding the inner tube, the outer tube effective to insulate the inner tube and electrically isolate the
inner tube such that the current applied to the conductive metal material of the inner tube is not provided to the outer tube;
and

an air gap between the inner tube and the outer tube.

US Pat. No. 9,302,225

SAMPLE COMPONENT TRAPPING, RELEASE, AND SEPARATION WITH MEMBRANE ASSEMBLIES INTERFACED TO ELECTROSPRAY MASS SPECTROMETRY

PerkinElmer Health Scienc...

1. An apparatus for analyzing chemical species, comprising:
a. at least one membrane assembly each configured with a semipermeable membrane separating a first flow channel and a second
flow channel, and an electrode positioned in the second flow channel;

b. a fluid delivery system configured to introduce a sample into the first flow channel;
c. an ion source interfaced to an outlet of the first flow channel of the at least one membrane assembly so that the sample
is ionized by the ion source and detected by a mass spectrometer;

and
d. a chromatography column or an electrically insulated open channel connected downstream of the outlet of the first flow
channel, wherein during operation of the apparatus, a first solution and a second solution flow in the first and second flow
channels, respectively.

US Pat. No. 9,177,777

ORTHOGONAL ACCELERATION SYSTEM FOR TIME-OF-FLIGHT MASS SPECTROMETER

PerkinElmer Health Scienc...

1. A method, comprising:
directing an ion beam in a first direction within a region between a first electrically-conductive plate extending in a first
plane and a second plate extending in a second plane parallel to the first plane, the second plate comprising a grid that
defines a plurality of apertures each having a first dimension extending in the first direction and a second dimension orthogonal
to the first dimension, the first and second dimensions lying in the second plane and the second dimension being larger than
the first dimension;

receiving an ion beam propagating in the first direction in the region between the first and second plates while a first electric
field between the first and second plates is essentially zero; and

applying a first voltage on the first electrically-conductive plate to produce a second electric field between the first and
second plates to accelerate at least a portion of ions in the ion beam in the region through the apertures of the second plate
such that an electric field strength in the region between the first and second plates is essentially identical to an electric
field strength in a region on an opposite side of the second plate, away from the first plate.

US Pat. No. 9,299,553

ATMOSPHERIC PRESSURE ION SOURCE FOR MASS SPECTROMETRY

PerkinElmer Health Scienc...

1. An apparatus for generating ions comprising;
a. two Electrospray inlet probes, the two Electrospray inlet probes are arranged with opposing symmetry about an axis of the
apparatus;

b. two ring electrodes each positioned proximal to an exit end of a corresponding one of the two Electrospray inlet probes
so that during use of the apparatus, the two ring electrodes each shields a local electric field at the corresponding exit
end from being modified by an electric field external to the exit ends;

c. means for applying voltages to the two ring electrodes to independently control the Electrospray ionization process of
each of the two Electrospray inlet probes; and

d. means for delivering sample solution to at least one of the at least two Electrospray inlet probes to produce sample ions
in a sample solution spray.

US Pat. No. 9,198,275

INDUCTIVE DEVICES AND LOW FLOW PLASMAS USING THEM

PERKINELMER HEALTH SCIENC...

1. A system for sustaining a plasma, the system comprising:
a plate electrode comprising an aperture configured to receive a torch,
a torch sized and arranged to be positioned within at least some portion of the aperture of the plate electrode, the torch
comprising an outer tube and an auxiliary tube within the outer tube, in which the outer tube comprises a slot configured
to provide the outer tube with a substantially equal radius along an entire length of the outer tube, the torch configured
to permit generation of the plasma in the torch at a plasma gas flow rate of about 8 liters/minute or less.

US Pat. No. 9,190,253

SYSTEMS AND METHODS OF SUPPRESSING UNWANTED IONS

PERKINELMER HEALTH SCIENC...

1. A system comprising:
an ion source;
ion optics fluidically coupled to the ion source;
a mass analyzer fluidically coupled to the ion optics, in which the mass analyzer is the only mass analyzer in the system;
a cell fluidically coupled to the mass analyzer and downstream of the mass analyzer; and
a detector fluidically coupled to the cell.

US Pat. No. 9,433,072

OXIDATION RESISTANT INDUCTION DEVICES

PerkinElmer Health Scienc...

1. A method of generating a plasma comprising:
introducing a gas into a torch body;
providing radio frequency energy to the torch using an induction device comprising an oxidation resistant material, in which
the induction device is configured as a helical induction coil comprising a plurality of coil turns coupled to each other,
in which the coil turns comprise an effective amount of the oxidation resistant material to permit a plasma to be sustained
in the torch body for at least ten hours without substantial oxidation of the helical induction coil;

igniting the gas in the torch body to generate the plasma; and
sustaining the plasma in the torch body for at least ten hours without substantial oxidation of the helical induction coil.

US Pat. No. 9,396,914

OPTICAL DETECTORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. An optical system configured to receive photons, the optical system comprising a photocathode configured to receive the
photons, an anode and a plurality of dynodes, between the photocathode and the anode, in which each of the plurality of dynodes
is configured to amplify an electron signal representative of the photons received by the photocathode, in which each of the
plurality of dynodes is electrically coupled to a respective electrometer to provide a plurality of dynode-electrometer pairs;
and
a first processor electrically coupled to each respective electrometer, in which the first processor is configured to measure
an output signal from each dynode of the plurality of dynode-electrometer pairs and to terminate signal amplification at a
saturated dynode of the plurality of dynode-electrometer pairs.

US Pat. No. 9,500,588

FLOW CELL MODULES AND LIQUID SAMPLE ANALYZERS AND METHODS INCLUDING SAME

PerkinElmer Health Scienc...

1. A liquid sample analyzer comprising:
a liquid sample source;
a flow cell configured to receive a flow of a liquid sample from the liquid sample source;
an optical device; and
a plurality of optical fibers optically connecting the flow cell to the optical device to transmit light between the flow
cell and the optical device;

wherein the plurality of optical fibers are configured as a fiber optic bundle having a terminal end coupled to the flow cell;
and

wherein:
each of the optical fibers includes an optical fiber end face;
the optical fiber end faces collectively form a fiber bundle end face at the terminal end of the fiber optic bundle; and
the fiber bundle end face is terminated at the flow cell to transmit light to or from the flow cell through the fiber bundle
end face.

US Pat. No. 9,412,572

SAMPLE HOLDERS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A sample holder comprising:
a first plate comprising configured to permit a sample on a sample support to be contacted by fluid for direct sample analysis,
the first plate comprising a retaining device and a plurality of apertures; and

a second plate rotatably coupled to the first plate and comprising a same number of apertures as the plurality apertures of
the first plate, the second plate configured to rotate about a longitudinal axis of the second plate to engage the first plate
and retain the sample support between the first plate and the second plate, in which the retaining device of the first plate
is configured to engage the second plate to the first plate in a first position to retain the sample support between the first
plate and the second plate and to disengage the second plate from the first plate in a second position to permit removal of
the sample support from the sample holder, and in which the apertures of the first plate and the second plate comprise a same
size and geometry, and wherein when the first plate is engaged to the second plate in the first position the apertures of
the first plate align with apertures of the second plate.

US Pat. No. 9,269,552

ION DETECTORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A mass spectrometer comprising:
a sample introduction system;
an ion source fluidically coupled to the sample introduction system;
a mass analyzer fluidically coupled to the ion source;
a detector fluidically coupled to the mass analyzer, in which the detector comprises an electron multiplier comprising a plurality
of dynodes each electrically coupled to a respective electrometer; and

a first processor electrically coupled to each respective electrometer, in which the first processor is configured to measure
an output signal from each dynode of the plurality of dynodes and to terminate signal amplification at a saturated dynode
of the plurality of dynodes.

US Pat. No. 9,240,311

APPARATUS FOR ANALYSIS OF SAMPLE CHEMICAL SPECIES FEATURING MULTIPLE SAMPLE PLACEMENT LOCATIONS

PerkinElmer Health Scienc...

1. An apparatus for analysis of sample chemical species comprising:
an enclosure operating at approximately atmospheric pressure during operation of the apparatus;
a reagent ion or metastable species generator positioned in the enclosure, the reagent ion or metastable species generator
comprising an element that produces a corona or glow discharge during operation of the apparatus to generate a reagent ion
or metastable species, the reagent ion or metastable species generator comprises a gas inlet, a rotatable angled end, and
a removable end piece, the rotatable angled end being configured to be arranged proximate to the at least one sample holder;

at least one seal configured to prevent gaseous exchange with ambient air during sample analysis within the enclosure;
a sample holder assembly mounted on a translation stage positioned in the enclosure, the sample holder assembly comprising
at least one sample holder comprising a plurality of individual sample placement locations;

a chemical analyzer for detecting and analyzing an ionized sample chemical species during operation of the apparatus; and
a capillary arranged to direct the ionized sample chemical species into the chemical analyzer, wherein
during operation of the apparatus, the reagent ion or metastable species ionizes a sample chemical species positioned at a
corresponding sample placement location to generate the ionized sample chemical species.

US Pat. No. 9,355,831

ION GUIDE OR FILTERS WITH SELECTED GAS CONDUCTANCE

PerkinElmer Health Scienc...

1. A device comprising a multipole assembly comprising a plurality of poles, in which at least one of the poles of the multipole
assembly comprises an integral fluid path that fluidically couples an ion volume formed by the poles of the multipole assembly
to an outer volume of the multipole assembly, in which the integral fluid path is configured to decrease a pressure of a second
section of the multipole assembly downstream of a first section of the multipole assembly comprising the integral fluid path
by drawing gas from the ion volume into the outer volume, in which the first section and the second section are electrically
coupled to each other to permit an effective field to be provided by the multipole assembly to transmit ions through the first
section and the second section of the multipole assembly.

US Pat. No. 9,349,580

COUPLING DEVICES AND SOURCE ASSEMBLIES INCLUDING THEM

PerkinElmer Health Scienc...

1. A source assembly comprising a source configured to couple to a vacuum port of a vacuum chamber of an instrument comprising
a first pin and a second pin each extending radially from the instrument, the source assembly comprising:
a moveable component comprising a circumferential slot;
a stationary component comprising the source, in which the source comprises a plurality of lenses;
in which the stationary component further comprises a slot that is configured to receive the first in and the second in of
the instrument into the slot of the stationary component to align the source in the instrument when the first and second pins
engage the slot of the stationary component;

in which the moveable component is configured to provide an axial force to the stationary component upon rotational movement
of the moveable component in a first direction by compression of a spring, in which the moveable component is further configured
to release the provided axial force upon rotational movement of the moveable component in a second direction opposite the
first direction; and

in which rotational movement of the moveable component in the first direction is configured to engage the second pin in the
circumferential slot of the moveable component to lock the stationary component in place and compress the spring to thereby
provide a substantially fluid tight seal between the source and the vacuum chamber.

US Pat. No. 9,368,334

COLLISION CELLS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. An ion collision cell comprising:
a sectioned quadrature rod assembly configured to provide a collision region between an upstream region and a downstream region,
the sectioned quadrature rod assembly comprising first, second, third, and fourth pole segments in each region of the quadrature
rod assembly; and

a lens coupled to and in contact with two adjacent regions of the sectioned quadrature rod assembly, the lens comprising an
aperture and a plurality of separate conductive elements disposed on each side of the lens, in which a respective disposed
conductive element on each side of the lens contacts and is configured to electrically couple to the first, second, third,
and fourth pole segments of the adjacent regions of the sectioned quadrature rod assembly to permit an RF field to continue
at a pole/lens interface.

US Pat. No. 9,316,661

DEVICES, SYSTEMS AND METHODS FOR LOADING SAMPLES

PerkinElmer Health Scienc...

1. A system configured to accelerate viscous sample flow into a flow cell, the system comprising:
a sample introduction device configured to provide a positive pressure;
a flow cell fluidically coupled to the sample introduction device and configured to receive sample under the positive pressure
from the sample introduction device through a fluid inlet of the flow cell;

a timing fluid line between the sample introduction device and the fluid inlet of the flow cell, the timing fluid line sized
and arranged to provide a reference sample from the sample introduction device to the flow cell at a reference time;

a sensor fluidically coupled to the timing fluid line and at the fluid inlet of the flow cell, the sensor configured to determine
a time of arrival of the sample;

a valve fluidically coupled to the flow cell at an outlet of the flow cell; and
a pressure device fluidically coupled to the valve downstream of the valve, the pressure device configured to provide a negative
pressure to the flow cell when the valve is in a second state to accelerate flow of the sample into the flow cell and configured
to be fluidically decoupled from the flow cell when the valve is in a first state to permit sample to flow into the flow cell
under the positive pressure provided by the sample introduction device.

US Pat. No. 9,355,832

REFLECTRONS AND METHODS OF PRODUCING AND USING THEM

PerkinElmer Health Scienc...

1. A reflectron comprising:
a plurality of lenses, in which at least a first lens comprises a first planar body comprising a first surface and a second
surface, the first planar body comprising an aperture between a first side and a second side of the first surface of the first
planar body, the first planar body further comprising a plurality of separate and individual conductors spanning the aperture
from the first side to the second side of the first surface of the first planar body, each of the plurality of conductors
attached to the first surface of the first planar body at the first side and at the second side of the first surface, in which
the plurality of individual conductors are each substantially parallel to each other and are positioned in the same plane,
in which the first planar body further comprises a conductive element disposed on the first surface of the first planar body
and in contact with each of the plurality of conductors to permit current flow from the planar body to the plurality of conductors;
and

a plurality of transverse rods coupled to each of the plurality of lenses and effective to retain the plurality of lenses
substantially parallel to each other.

US Pat. No. 9,410,926

METHODS AND APPARATUS FOR IDENTIFICATION OF POLYMERIC SPECIES FROM MASS SPECTROMETRY OUTPUT

PERKINELMER HEALTH SCIENC...

1. A method for identifying a species of an unidentified chemical compound comprising repeating structural units, and one
or more end units, the method comprising:
accessing at least a portion of mass spectrometry data, wherein the portion of mass spectrometry data relates to a sample
comprising the unidentified chemical compound;

identifying an estimated mass of the unidentified chemical compound;
determining an estimated mass of the portion of the unidentified chemical compound made up of the repeating structural units;
and

identifying, by a processor of a computing device, one or more candidate chemical formulas for the unidentified chemical compound
based at least in part on:

(i) the mass spectrometry data for the unidentified chemical compound;
(ii) the estimated mass of the unidentified chemical compound; and
(iii) the estimated mass of the portion of the unidentified chemical compound made up of the repeating structural units.

US Pat. No. 9,648,717

HYBRID GENERATORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A generator configured to provide power to sustain an inductively coupled plasma in a torch body in a driven mode and in
an oscillation mode, the generator comprising:
a circuit configured to electrically couple to an induction device and provide power to the induction device in the driven
mode to sustain the inductively coupled plasma in the torch body in the driven mode and configured to provide power to the
induction device in the oscillation mode to sustain the inductively coupled plasma in the torch body in the oscillation mode;
and

a processor electrically coupled to the circuit and configured to switch operation of the circuit between the driven mode
and the oscillation mode.

US Pat. No. 9,591,737

INDUCTION DEVICES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A device for sustaining an ionization source in a torch comprising a longitudinal axis along which a flow of gas is introduced
during operation of the torch, the device comprising:
a base configured to provide a coil comprising a first coil turn and a second coil turn to provide an inner aperture formed
from the first and second coil turns, in which the inner aperture is constructed and arranged to receive a body of the torch;
and

a first radial fin coupled to the first coil turn and a second radial fin coupled to the second coil turn, in which the device
is configured to provide radio frequency energy to the body of the torch to sustain the ionization source within the torch.

US Pat. No. 9,625,417

ION DETECTORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A method of detecting ions, the method comprising:
simultaneously detecting an input current signal at each dynode of a plurality of dynodes of an electron multiplier configured
to receive ions, in which each dynode is electrically coupled to a respective electrometer and wherein each dynode-electrometer
pair is electrically coupled to a first processor configured to simultaneously detect the input and output current signals
at each dynode of the plurality of dynodes; and

averaging the detected input current signals at each dynode with a detected current input signal above a noise current input
signal and below a saturation current input signal to determine a mean electron multiplier input current.

US Pat. No. 9,562,895

ASSAY PARTICLES AND METHODS OF USE

PerkinElmer Health Scienc...

1. A method for detecting protein kinase activity, the method comprising:
contacting a sample suspected of containing a protein kinase with:
(i) an assay particle, wherein the assay particle comprises:
a core portion encased by a shell portion; and
a coat portion covering the shell portion,
wherein the shell portion of the assay particle comprises titanium dioxide and a material selected from the group consisting
of glass, ceramic, and combinations thereof;

wherein the coat portion comprises titanium dioxide and a target selective binding agent; and
wherein the assay particle is hollow and is buoyant in aqueous media; and
(ii) a protein kinase substrate comprising a moiety capable of emitting radiation under conditions wherein the protein kinase
can phosphorylate the substrate to produce a phosphorylated substrate;

wherein binding of the phosphorylated substrate to titanium dioxide produces a light signal; and
determining a protein kinase activity based on a level of detected light signal.

US Pat. No. 9,589,780

SYSTEMS AND METHODS OF SUPPRESSING UNWANTED IONS

PerkinElmer Health Scienc...

1. A mass spectrometry system comprising a single mass analyzer, the system comprising:
an ion source;
ion optics fluidically coupled to the ion source and downstream of the ion source;
a single mass analyzer fluidically coupled to the ion optics and downstream of the ion optics so the ion optics are between
the ion source and the single mass analyzer, in which the single mass analyzer is the only mass analyzer present in the system;

a cell fluidically coupled to the single mass analyzer and downstream of the single mass analyzer so the single mass analyzer
is between the cell and the ion optics; and

a detector fluidically coupled to the cell and downstream of the cell so the cell is between the single mass analyzer and
the detector.

US Pat. No. 9,686,849

TORCHES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A system for sustaining an atomization source, the system comprising:
a torch comprising a hollow cylindrical outer tube comprising an entrance end and an exit end, in which the entrance end and
the exit end of the torch are coupled to each other through at least one material, in which the entrance end of the torch
comprises a non-refractory material, and in which a terminal end of the exit end of the torch comprises at least one refractory
material; and

an induction device comprising an aperture configured to receive the torch and provide radio frequency energy to the torch
to sustain the atomization source in the torch.

US Pat. No. 9,748,084

DIRECT SAMPLE ANALYSIS DEVICE ADAPTERS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A method of installing a direct sample analysis device on a mass spectrometer while maintaining a vacuum in the mass spectrometer,
the method comprising:
coupling a capillary extension to the capillary inlet, in which the capillary extension is configured to couple to the capillary
inlet through a friction fit between outer surfaces of the capillary inlet and inner surfaces of the capillary extension;
and

coupling an end cap extension to the coupled capillary extension, in which the coupled capillary extension and coupled capillary
end cap are configured to provide fluidic coupling between a direct sample analysis sample holder and the mass spectrometer
through the capillary inlet.

US Pat. No. 9,751,040

FLUIDIC DEVICES AND METHODS USING THEM

PerkinElmer Health Scienc...

9. A system comprising:
a microfluidic device comprising a laminated wafer body comprising an inlet port, a first outlet port and a second outlet
port, in which each of the first outlet port and the second outlet port is fluidically coupled to the inlet port through an
internal microchannel in the laminated wafer body, the microfluidic device constructed and arranged to permit three-way switching;

a first switching valve fluidically coupled to the microfluidic device and configured to provide a switching gas to at least
two ports of the microfluidic device to provide sample flow from the inlet port to the first outlet port; and

a second switching valve fluidically coupled to the microfluidic device and configured to provide a switching gas to at least
two ports of the microfluidic device to provide sample flow from the inlet port to the second outlet port.

US Pat. No. 9,649,716

INDUCTIVE DEVICES AND LOW FLOW PLASMAS USING THEM

PerkinElmer Health Scienc...

1. A method of sustaining a plasma in a torch comprising a slot in an outer tube and an auxiliary tube within the outer tube,
the slot configured to provide the outer tube with a substantially equal radius along an entire length of the outer tube and
the auxiliary tube configured to permit generation of the plasma in the torch at a plasma gas flow rate of about 8 liters/minute
or less, the method comprising
introducing a plasma gas at a rate of about 8 liters/minute or less into the torch;
sustaining the plasma in the torch at the plasma gas flow rate of 8 liters/minute or less by providing energy to the torch
from at least one plate electrode.

US Pat. No. 9,810,668

AUTOSAMPLER AND GAS CHROMATOGRAPHY SYSTEM AND METHOD INCLUDING SAME

PerkinElmer Health Scienc...

1. A gas chromatography system comprising:
at least one gas chromatography subsystem including a first injector port and a second injector port;
an autosampler including:
a carousel tray mounted for rotation about a rotation axis, wherein the carousel tray is mounted above the first and second
injector ports, and wherein the carousel tray includes:

an arcuately extending first row of sample reservoirs; and
an arcuately extending second row of sample reservoirs;
a first sample transfer tower to extract samples from the first row of sample reservoirs;
a second sample transfer tower to extract samples from the second row of sample reservoirs; and
a control system operative to:
selectively position the carousel tray relative to the first and second sample transfer towers to align the first sample transfer
tower with a first sample reservoir in the first row and to align the second sample transfer tower with a second sample reservoir
in the second row;

simultaneously draw a first sample from the first sample reservoir using the first sample transfer tower and a second sample
from the second sample reservoir using the second sample transfer tower; and sequentially thereafter

simultaneously inject the first sample into the first injector port using the first sample transfer tower and the second sample
into the second injector port using the second sample transfer tower.

US Pat. No. 9,682,860

PROCESSES AND APPARATUSES FOR RECLAMATION AND PURIFICATION OF TRITIUM

PerkinElmer Health Scienc...

1. A process of reclaiming tritium from a tritium containing byproduct stream comprising:
oxidizing a tritium containing organic material for an oxidation time and at an oxidation temperature to produce tritiated
water;

splitting said tritiated water to a solid oxygen containing species and a tritiated gas species; and
trapping said tritiated gas species.
US Pat. No. 9,575,064

METHODS RELATING TO TESTING FOR LYSOSOMAL STORAGE DISORDERS

PerkinElmer Health Scienc...

1. A process for detecting enzymatic activity in vitro, comprising:
contacting a sample containing a target enzyme with a substrate and one or more oleate salts wherein said salt is selected
from the group consisting of sodium, magnesium, potassium, calcium, lithium and zinc, said step of contacting is performed
under conditions wherein the target enzyme is lysosomal storage enzyme capable of acting on the substrate to produce an enzymatic
product, and wherein said oleate salt allows for improved enzyme activity, detection of lower enzyme amounts, and/or greater
reproducibility; and

detecting said enzymatic product, wherein said target enzyme is acid ?-galactosidase A, acid ?-glucocerebrosidase, galactocerebrosidase,
acid ?-glucosidase, acid sphingomylenase, ?-L-iduronidase, or combinations thereof.

US Pat. No. 9,810,636

INDUCTION DEVICE

PerkinElmer Health Scienc...

1. A method of detecting an analyte species comprising:
introducing an analyte species into a torch having a longitudinal axis along which a flow of gas is introduced during operation
of the torch and having a radial plane substantially perpendicular to the longitudinal axis of the torch;

providing a loop current along the radial plane of the torch using a device configured to generate an inductively coupled
plasma in the torch, the device comprising a first plate electrode configured to couple to a power source; and

detecting an optical emission from the analyte species introduced into the plasma generated in the torch.

US Pat. No. 9,754,774

SYSTEMS AND METHODS FOR AUTOMATED ANALYSIS OF OUTPUT IN SINGLE PARTICLE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY AND SIMILAR DATA SETS

PerkinElmer Health Scienc...

1. A method for automated analysis of spectrometry data corresponding to particles of a sample, the method comprising:
(a) detecting, by a detector of an inductively coupled plasma mass spectrometer (ICP-MS), one or more ions, wherein the spectrometer
acquires a sequence of pulse count values in response to the one or more ions striking the detector;

(b) accessing, by a processor of a computing device, the sequence of pulse count values, wherein the sequence of pulse count
values is acquired by the spectrometer at a rate fast enough to produce, for at least one given peak corresponding to an individual
particle comprising an analyte in the sample, a plurality of pulse count values each of which is greater than a threshold
background intensity value;

(c) determining, by the processor, from a first array of the pulse count values, a threshold for identifying pulse count values
as corresponding to a peak signal, and adjusting the threshold based on remaining pulse count values following each of a series
of iterations, with a given subsequent iteration further excluding pulse count values identified as corresponding to a peak
in the preceding iteration, wherein a final background threshold is determined upon convergence of the threshold within acceptable
tolerance;

(d) building, by the processor, from the first array of the pulse count values, a smoothed data array, identifying as peaks
the values of the smoothed data array that are larger than both subsequent and preceding values and larger than the final
background threshold;

(e) identifying, by the processor, a peak area intensity corresponding to each of the identified peaks for the sample and
constructing, by the processor, a histogram of peak area intensities for the sample;

(f) computing, by the processor, using the histogram of peak area intensities for the sample, one or more of (i) to (ix) as
follows: (i) a particle mass histogram for the sample, (ii) a particle size histogram for the sample, (iii) a number of peaks
detected for the sample, (iv) a particle concentration for the sample, (v) a mean particle size for the sample, (vi) a median
particle size for the sample, (vii) a dissolved analyte concentration for the sample, (viii) a mode particle size, and (ix)
a measure of width of particle size distribution; and

(g) rendering, by the processor, for presentation on a display, a graphical and/or alphanumeric representation of one or more
of (i) to (xi) as follows: (i) the identified peaks for the sample, (ii) the histogram of peak area intensities for the sample,
(iii) the particle mass histogram for the sample, (iv) the particle size histogram for the sample, (v) the number of peaks
detected for the sample, (vi) the particle concentration for the sample, (vii) the mean particle size for the sample, (viii)
the median particle size for the sample, (ix) the dissolved analyte concentration for the sample, (x) the mode particle size,
and (xi) the measure of width of particle size distribution;

wherein step (f) further comprises:
determining, by the processor, an intensity versus mass calibration for the sample using: (I) a most-common intensity determined
from an intensity histogram produced from an ICP-MS run of a standard particle having a known size and the same composition
as the particles of the sample, (II) a determined or known shape of the standard particle, and (III) a determined or known
density of the standard particle; and

computing the particle mass histogram for the sample using: (I) the intensity versus mass calibration for the sample, (II)
a mass fraction of the particle that is the analyte, and (III) an ionization efficiency.

US Pat. No. 9,581,491

FLOW CELL MODULES AND LIQUID SAMPLE ANALYZERS AND METHODS INCLUDING SAME

PerkinElmer Health Scienc...

1. A flow cell for a fluorescence spectrometer, the flow cell comprising:
a flow channel to receive a flow of a liquid sample;
an excitation light entrance window to receive excitation light from a light source; and
an emission light exit window to transmit fluorescent emission light from the liquid sample in the flow channel from the flow
cell;

wherein the excitation light entrance window and/or emission light exit window includes a waveguide including:
a waveguide core formed of a core material and having an inner end face; and
a cladding medium surrounding a portion of the waveguide core, wherein the cladding medium has a refractive index less than
the refractive index of the core material;

wherein the inner end face of the waveguide:
defines a portion of the flow channel;
serves as a light input port for the excitation light into the flow channel or a light output port for the fluorescent emission
light out of the flow channel; and

contacts the liquid sample in the flow channel; and
wherein the flow cell includes an end pad of opaque, light absorbing material surrounding an end portion of the waveguide
core adjacent the flow channel and adjacent the inner end face of the waveguide, wherein the end pad prevents light from propagating
directly from the excitation light entrance window to the excitation light exit window.

US Pat. No. 9,576,782

ORTHOGONAL ACCELERATION SYSTEM FOR TIME-OF-FLIGHT MASS SPECTROMETER

PerkinElmer Health Scienc...

1. An orthogonal pulse accelerator for a Time-of-Flight mass analyzer, comprising:
an electrically-conductive first plate extending in a first plane;
a second plate spaced from the first plate, the second plate extending in a second plane parallel to the first plane, the
second plate comprising a grid that defines a plurality of apertures each having a first dimension extending in a first direction
and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the
second dimension being larger than the first dimension;

an electrically-conductive third plate spaced from the second plate, the third plate comprising a second grid defining a second
plurality of apertures;

an electrically-conductive fourth plate spaced from the third plate, the fourth plate comprising a third grid defining a third
plurality of apertures; and

a voltage source configured to apply a constant voltage to the fourth plate during operation of the mass analyzer,
wherein the first and second plates are positioned in the Time-of-Flight mass analyzer to receive, during operation of the
mass analyzer, an ion beam propagating in the first direction in a region between the first and second plates while a first
electric field between the first and second plates is essentially zero, and the orthogonal pulse accelerator directs ions
in the ion beam through the plurality of apertures of the second plate when a second electric field is applied between the
first and second plates, where ions passing through the plurality of apertures of the second plate are directed through the
second plurality of apertures of the third plate and through the third plurality of apertures of the fourth plate.

US Pat. No. 9,638,675

GAS CHROMATOGRAPHY OVEN AND SYSTEMS AND METHODS INCLUDING SAME

PerkinElmer Health Scienc...

13. A gas chromatography system comprising:
a gas chromatography oven including:
a housing defining an oven chamber and an intake port fluidly communicating with the oven chamber; and
a fluid flow generating system including a radial flow impeller; and
a gas chromatography column disposed in the oven chamber;
wherein the oven is configured to selectively operate in each of:
a cooling mode wherein the radial flow impeller generates a cooling fluid flow that is drawn from the intake port and flows
about the column and out of the oven chamber; and alternatively

a recirculating mode wherein the radial flow impeller generates a recirculating fluid flow within the oven chamber that repeatedly
flows about the column and back to the radial flow impeller; and

wherein:
the radial flow impeller rotates about an impeller axis;
the impeller axis extends through the intake port;
in each of the cooling mode and the recirculating mode, the radial flow impeller discharges a forced fluid flow radially outwardly
therefrom;

the column is configured in a substantially circular column loop; and
the radial flow impeller is located within the column loop so that the forced fluid flow is directed toward the column.

US Pat. No. 9,613,788

RF ION GUIDE WITH AXIAL FIELDS

PerkinElmer Health Scienc...

1. An apparatus, comprising:
an ion source;
a mass analyzer; and
an RF ion guide positioned in an ion path between the ion source and the mass analyzer, the RF ion guide having an ion guide
axis extending between an input end of the RF ion guide and an exit end of the RF ion guide, the RF ion guide comprising:

a first electrode extending along the ion guide axis, the first electrode configured to be connected to a voltage source;
and

a second electrode extending along the ion guide axis, the second electrode configured to be connected to a RF source, a portion
of the second electrode being positioned between the first electrode and the ion guide axis, the second electrode comprising
a plurality of openings, wherein during use of the apparatus, the second electrode produces RF electric fields within a central
portion of the RF ion guide throughout a region between the second electrode and the ion guide axis to radially confine ions,

wherein the first and second electrodes are configured so that during operation of the RF ion guide, a DC electric field is
generated between the first and second electrodes, resulting in a DC electric field at the ion guide axis that has a non-zero
axial component.

US Pat. No. 9,733,156

SAMPLE PLATFORMS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A sample holder assembly for use in direct sample analysis, the sample holder assembly comprising:
a sample platform configured to retain a sample support effective to retain a sample for direct sample analysis, the sample
platform comprising at least one aperture, the sample platform further comprising an orientation contact projecting from a
surface of the sample platform and configured to engage a rear surface of the sample support to position the sample support
on the sample platform, the sample platform further comprising an actuation contact configured to engage a sealing device
as the sample platform is raised to permit loading of sample on or in the sample support, the actuation contact further configured
to disengage the sealing device when the sample platform is lowered to permit analysis of sample loaded into the sample support;
and

an electrical coupler integral to the sample support and configured to couple to the sample platform through the at least
one aperture of the sample platform to retain the sample support on the sample platform and provide electrical coupling of
the sample support to ground.

US Pat. No. 9,848,486

INDUCTION DEVICES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A system for sustaining an ionization source, the system comprising:
a torch comprising a body comprising a longitudinal axis along which a flow of gas is introduced during operation of the torch;
and

a device comprising a base constructed and arranged as a coil comprising a first coil turn and a second coil turn to provide
an inner aperture formed from the first and second coil turns, in which the inner aperture is configured to receive a portion
of the torch body, the device further comprising a first radial fin coupled to the first coil turn and a second radial fin
coupled to the second coil turn, in which the device is configured to provide radio frequency energy to the portion of the
torch body received by the inner aperture to sustain the ionization source within the portion of the torch body.

US Pat. No. 9,847,214

DETECTORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A mass spectrometer comprising:
a sample introduction system;
an ion source fluidically coupled to the sample introduction system;
a mass analyzer fluidically coupled to the ion source; and
a single detector fluidically coupled to the mass analyzer and configured to split a beam received from the mass analyzer
into a first beam and a second beam, in which the single detector comprises a plurality of dynodes, in which at least two
dynodes of the plurality of dynodes are each electrically coupled to a respective electrometer, in which the single detector
comprises a processor configured to measure a non-saturated analog signal, using the first beam, from one of the at least
two dynodes electrically coupled to its respective electrometer, in which the single detector is configured to count pulses,
using the second beam, to provide a pulse count signal, and in which the processor is configured to cross-calibrate the measured
non-saturated analog signal with the pulse count signal to provide a calibration curve.

US Pat. No. 9,818,592

ION GUIDE OR FILTERS WITH SELECTED GAS CONDUCTANCE

PerkinElmer Health Scienc...

1. A mass spectrometer comprising:
a sample introduction device;
an ionization device fluidically coupled to the sample introduction device;
a mass analyzer fluidically coupled to the ionization device, the mass analyzer comprising a multipole assembly comprising
a plurality of poles, in which at least one of the poles of the multipole assembly comprises an integral fluid path that fluidically
couples an ion volume formed by the poles of the multipole assembly to an outer volume of the multipole assembly, in which
the integral fluid path is configured to decrease a pressure of a second section of the multipole assembly downstream of a
first section of the multipole assembly comprising the integral fluid path by drawing gas from the ion volume into the outer
volume, in which the first section and the second section are electrically coupled to each other to permit a field to be provided
by the multipole assembly to transmit ions through the first section and the second section of the multipole assembly; and

a detector fluidically coupled to the mass analyzer.

US Pat. No. 9,600,001

DEVICES, SYSTEMS AND METHODS FOR PURGING AND LOADING SORBENT TUBES

PerkinElmer Health Scienc...

1. A device configured to load a sorbent tube with a desired level of water using a fluid flow comprising humidified fluid,
the device comprising a humidity sensor constructed and arranged to fluidically couple to the sorbent tube, the humidity sensor
separate from the sorbent tube and configured to receive a fluid stream from the sorbent tube to determine the level of water
in the sorbent tube, and a processor electrically coupled to the humidity sensor, the processor configured to permit the fluid
flow comprising the humidified fluid into the sorbent tube when the determined level of water in the sorbent tube is below
a desired level and to stop the fluid flow into the sorbent tube when the determined level of water in the sorbent tube reaches
a desired level, in which the humidity sensor is configured to detect an inflection point as an indicator of the desired level
of water in the sorbent tube and wherein the desired level of water in the sorbent tube is measured by the humidity sensor
to be about 3% relative humidity when the fluid flow into the sorbent tube is stopped by the processor.

US Pat. No. 9,859,106

REFLECTRONS AND METHODS OF PRODUCING AND USING THEM

PerkinElmer Health Scienc...

1. A method of assembling a reflectron comprising:
inserting a plurality of ion lenses into an assembly jig comprising a plurality of slots each sized and arranged to receive
a single ion lens and position the ion lens substantially parallel to each other, wherein at least one of the plurality of
ion lenses comprises a plurality of separate and individual conductors spanning the aperture from a first side to a second
side of a first surface of the at least one ion lens, each of the plurality of conductors attached to the first surface at
the first side and at the second side, in which the plurality of individual conductors are each substantially parallel to
each other and are positioned in a same plane;

inserting at least one transverse rod through rod apertures in each of the inserted ion lenses in the assembly jig; and
coupling the inserted transverse rod to each of the inserted ion lenses.

US Pat. No. 9,824,876

FLUID CHROMATOGRAPHY INJECTORS AND INJECTOR INSERTS

PerkinElmer Health Scienc...

1. A fluid injector insert comprising an injector insert inlet coupled to a separate injector insert outlet to provide a channel
between the coupled injector insert inlet and the injector insert outlet, wherein the injector insert inlet is constructed
and arranged to couple to an injector assembly to fluidically couple a fluid flow path of the injector insert to a fluid flow
path of the injector assembly so that a top surface of the injector insert inlet will be exposed to sample in the fluid flow
path of the injector assembly, wherein the top surface of the injector insert inlet comprises a substantially inert metal
material that is exposed to sample in the fluid flow path of the injector assembly, and wherein the injector insert outlet
and the channel are configured to receive a column to fluidically couple the received column to the injector insert inlet
to provide fluidic coupling between the injector insert inlet and the column to permit sample to flow to the column.

US Pat. No. 9,847,217

DEVICES AND SYSTEMS INCLUDING A BOOST DEVICE

PerkinElmer Health Scienc...

1. A method comprising:
providing inductive energy into a chamber from an induction device to sustain an atomization source at a first area within
the chamber using inductive energy from the induction device; and

providing additional radio frequency energy from a boost device into a second area of the chamber different from the first
area of the chamber, in which the boost device is separate from the induction device and in which the first area of the chamber
has the same diameter as the second area of the chamber, and wherein the boost device comprises an aperture that receives
the second area of the chamber to position the boost device around the second area of the chamber, and wherein the boost device
comprises a wire coil that wraps around the second area of the chamber.

US Pat. No. 9,942,974

HYBRID GENERATORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A mass spectrometer comprising:a torch configured to sustain an ionization source;
an induction device comprising an aperture for receiving a portion of the torch and configure to provide radio frequency energy into the received torch portion;
a generator electrically coupled to the induction device and configured to provide power to sustain an inductively coupled plasma in the torch portion received by the induction device, the generator comprising a circuit configured to electrically couple to an induction device and provide power to the induction device in the driven mode to sustain the inductively coupled plasma in the received torch portion in the driven mode and configured to provide power to the induction device in the oscillation mode to sustain the inductively coupled plasma in the received torch portion in the oscillation mode; and
a mass analyzer fluidically coupled to the torch.

US Pat. No. 9,922,810

SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF SELENIUM AND SILICON IN SAMPLES

PerkinElmer Health Scienc...

1. A method for producing a stream of ions for detection and/or quantification of silicon (Si) in a petrochemical sample,
the method comprising:
introducing a petrochemical sample to an ionization source, thereby producing an ionized sample stream comprising a plurality
of ionic species, said plurality of ionic species comprising:

(i) one or more analyte ionic species, said one or more analyte ionic species being an ionized form of one or more species
of interest present in the petrochemical sample, said one or more species of interest comprising silicon, and said one or
more analyte ionic species comprising Si+; and

(ii) one or more interferer ionic species, said one or more interferer ionic species having nominal m/z substantially equivalent
to that of Si+;

admitting the ionized sample stream into a chamber to thereby contact the ionized sample stream with a reaction gas stream
comprising CO2, thereby reacting the CO2 with at least one of the one or more interferer ionic species and producing one or more products that are not interferer ionic
species; and,

following contact of the ionized sample stream with the reaction gas stream comprising CO2, directing the resulting product stream to a mass analyzer and detector for detection and/or quantification of silicon in
the petrochemical sample.

US Pat. No. 9,899,202

TIME OF FLIGHT TUBES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A time of flight tube assembly comprising:
an inner tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside
the inner tube, the inner tube comprising a conductive material disposed on an inner surface of the inner tube, the conductive
material present in an effective amount to provide a field free region for ions when the conductive material is charged;

an outer tube surrounding the inner tube, the outer tube effective to insulate the inner tube and electrically isolate the
inner tube;

an air gap between the inner tube and the outer tube, wherein the outer tube is coupled to the inner tube through blocks to
permit removal of the outer tube and inner tube together as a unit; and

a reflectron assembly coupled to the inner tube, the reflectron assembly comprising a lens stack.

US Pat. No. 9,916,969

MASS ANALYSER INTERFACE

PerkinElmer Health Scienc...

1. A mass analyser interface, comprising:
a desolvation chamber having a generally cylindrical wall, said desolvation chamber maintained at a pressure between 10 Torr
and 700 Torr, and having an inlet for receiving neutral solvated analyte particles from a source of analyte particles, and
an outlet aperture for feeding ionized particles from said desolvation chamber to downstream stages of a mass analyzer;

an electric field source, for providing an electric field to urge ionized particles within said desolvation chamber from said
inlet toward said outlet aperture, and a containment field to contain said ionized particles about a guide axis, creating
a downstream flow of said ionized particles along said guide axis to said downstream stages of said mass analyzer;

a gas injection port to inject an upstream gas proximate said outlet aperture, to provide a counter-flow to said downstream
flow at said outlet aperture, to slow solvated ionized particles and neutral particles in said downstream flow more than desolvated
ionized particles in said downstream flow as said desolvated ionized particles travel toward said outlet aperture;

at least one evacuation port formed downstream of said inlet on said generally cylindrical wall, to allow injected gas to
escape from said desolvation chamber, in a direction away from said guide axis;

an annular shroud, encircling said guide axis and in flow communication with said at least one evacuation port, and said annular
shroud having an aperture that guides injected gas to flow from said desolvation chamber into said at least one evacuation
port generally parallel to said guide axis;

a pump in flow communication with said at least one evacuation port and said aperture, said pump and said at least one evacuation
port configured to guide a counter-flow of said injected gas away from said outlet aperture and toward said inlet, and through
said annular shroud and through said at least one evacuation port.

US Pat. No. 10,104,755

INDUCTION DEVICES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A method of sustaining an ionization source within a torch, the method comprising:introducing a flow of gas into the torch along a longitudinal axis of a body of the torch; and
sustaining a plasma within the torch by providing radio frequency energy into the torch using an induction device, wherein the induction device comprises a base comprising a first coil turn and a second coil turn to provide an inner aperture formed from the first and second coil turns, in which the inner aperture is constructed and arranged to receive the body of the torch, wherein the induction device further comprises a first radial fin coupled to the first coil turn and a second radial fin coupled to the second coil turn.

US Pat. No. 10,104,754

OSCILLATOR GENERATORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A system comprising:an induction device; and
a generator electrically coupled to the induction device and configured to sustain an inductively coupled plasma in a torch body, the generator comprising a processor and an oscillation circuit electrically coupled to the processor, the oscillation circuit configured to provide power to the induction device in an oscillation mode to sustain the inductively coupled plasma in the torch body, wherein the circuit is further configured to provide harmonic emission control during sustaining of the inductively coupled plasma in the torch body in the oscillation mode of the generator.

US Pat. No. 9,927,335

SAMPLE HOLDERS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A method of loading a sample for direct sample analysis, the method comprising providing a sample holder comprising a first plate configured to permit a sample on a sample support to be contacted by fluid for direct sample analysis, the first plate comprising a retaining device and a plurality of apertures, and a second plate rotatably coupled to the first plate and comprising a same number of apertures as the plurality of apertures of the first plate, the second plate configured to rotate about a longitudinal axis of the second plate to engage the first plate and retain the sample support between the first plate and the second plate, in which the retaining device of the first plate engages the second plate in a first position to retain the sample support between the first plate and the second plate and disengages the second plate in a second position to permit removal of the sample support from the sample holder, in which the apertures of the first plate and the second plate comprise a same size and geometry, and wherein when the first plate is engaged to the second plate in the first position the apertures of the first plate align with the apertures of the second plate.

US Pat. No. 9,916,971

SYSTEMS AND METHODS OF SUPPRESSING UNWANTED IONS

PerkinElmer Health Scienc...

1. A method comprising:
selecting native ions comprising a single mass-to-charge ratio from an ion beam comprising a plurality of ions with different
mass-to-charge ratios; and

providing the selected, native ions to a downstream cell.

US Pat. No. 10,088,494

METHOD AND SYSTEM FOR MICROFLUIDIC SAMPLE ANALYSIS

PERKINELMER HEALTH SCIENC...

1. A method for analyzing a sample, comprising the steps of:A) for a calibration sample having a first attribute with an expected value, analyzing the calibration sample using a set of analysis parameters;
B) calculating a measured value of the first attribute of the calibration sample based at least in part on the analysis of step A);
C) comparing the measured value to the expected value to determine whether the measured value varies from the expected value by more than a threshold amount;
D) if the measured value varies from the expected value by more than the threshold amount, then
1) adjusting at least one of the set of analysis parameters to create an adjusted set of analysis parameters;
2) performing steps A)-D) iteratively using the adjusted set of analysis parameters until the measured value varies from the expected value by less than the threshold amount; and
E) if the measured value varies from the expected value by less than the threshold amount, then analyzing a test sample using the first set of analysis parameters.

US Pat. No. 9,914,087

SORBENT DEVICES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

13. A method comprising:
exposing a sorbent device to an environment comprising volatile species to permit the volatile species to adsorb to the sorbent
device, the sorbent device comprising at least four different sorbent materials in which the sorbent materials are arranged
from a material with a weakest sorbent strength to a material with a strongest sorbent strength, according to their relative
ability to adsorb species, with the weakest sorbent strength material adjacent to a sampling inlet of the sorbent device,
in which the sorbent device further comprises a fluid permeable barrier disposed on the sorbent material and disposed between
each of the plurality of the at least four different sorbent materials, and wherein at least three of the at least four different
sorbent materials comprises a graphitized carbon black with none of the sorbent materials being the same; and

desorbing the species adsorbed to the sorbent device by heating the sorbent device in a single desorption cycle to desorb
substantially all adsorbed species in the sorbent device, in which the single desorption cycle comprises a single heating
step of heating the sorbent device from a starting temperature to a final temperature to desorb substantially all the adsorbed
species.

US Pat. No. 9,983,104

FLOW CONTROL DEVICES AND THEIR USE WITH EXPLOSIVE CARRIER GASES

PerkinElmer Health Scienc...

1. A gas chromatography system comprising:a temperature regulated column space configured to receive a chromatography column:
a sampling system fluidically coupled to the column space and configured to provide sample to the chromatography column in the column space, the sampling system comprising a flow control device configured to provide release of explosive carrier gas provided by a carrier gas fluid line in less than an explosive amount to void space in the sampling system, in which the sampling system is configured to use hydrogen gas as the explosive carrier gas, and in which the sampling system is configured to reduce sample run time by at least 40% using the explosive carrier gas comprising the hydrogen gas when compared to sample run time using helium as a carrier gas; and
a detector fluidically coupled to the column space and configured to receive analyte from the chromatography column.

US Pat. No. 10,032,617

RF ION GUIDE WITH AXIAL FIELDS

PerkinElmer Health Scienc...

1. An apparatus, comprising:an ion source;
a first mass analyzer;
a first RF ion guide positioned in an ion path between the ion source and the first mass analyzer, the RF ion guide having an ion guide axis extending between an input end of the first RF ion guide and an exit end of the first RF ion guide, the first RF ion guide comprising:
a first electrode extending along the first RF ion guide axis, the first electrode configured to be connected to a voltage source; and
a second electrode extending along the first RF ion guide axis, the second electrode configured to be connected to a RF source, a portion of the second electrode being positioned between the first electrode and the ion guide axis, the second electrode comprising a plurality of openings, wherein during use of the apparatus, the second electrode produces RF electric fields within a central portion of the first RF ion guide throughout a region between the second electrode and the ion guide axis to radially confine ions,
wherein the first and second electrodes are configured so that during operation of the first RF ion guide, a DC electric field is generated between the first and second electrodes, resulting in a DC electric field at the first ion guide axis that has a non-zero axial component throughout at least a portion of the length of the first ion guide; and
a first ion optical component positioned proximal to the exit end of the first ion guide, having a DC voltage applied that is adjustable such that the resulting potential distribution in the region of the first ion guide exit end either allows ions to exit the first ion guide exit end, or prevents ions from exiting the first ion guide exit end,
wherein at least a portion of the first RF ion guide is positioned in a region of gas pressure high enough that collisions between ions and gas molecules occur.

US Pat. No. 10,096,457

OXIDATION RESISTANT INDUCTION DEVICES

PerkinElmer Health Scienc...

1. A mass spectrometer comprising:a torch body configured to sustain an inductively coupled plasma;
an induction device comprising an oxidation resistant material and configured to provide radio frequency energy to the torch body to sustain the plasma in the torch body, wherein the induction device is configured as a helical induction coil comprising a plurality of coil turns coupled to each other, in which the coil turns comprise an effective amount of the oxidation resistant material to permit the inductively coupled plasma to be sustained in the torch body for at least ten hours without substantial oxidation of the helical induction coil; and
a mass analyzer in fluid communication with the torch body and configured to separate species based on mass-to-charge ratios.

US Pat. No. 10,024,829

MANIFOLDS AND METHODS OF USING THEM TO CONTROL FLUID FLOWS

PerkinElmer Health Scienc...

1. A manifold comprising first and second internal filament detectors cells within an integral housing, the manifold comprising a sample inlet port fluidically coupled to the first internal filament detector cell through a first restrictor between the sample inlet port and a first filament detector of the first internal filament detector cell, the manifold further comprising a make-up gas port fluidically coupled to the second internal filament detector cell through a second restrictor between the make-up gas port and a second filament detector of the second internal filament detector cell, wherein the second internal filament detector cell is separate from the first internal filament detector cell, and wherein the manifold further comprises an exit port fluidically coupled to each of the first and second filament detector cells, wherein each of the first and second filament detectors comprises two filaments, and wherein the first restrictor and the second restrictor comprise different internal dimensions.

US Pat. No. 10,145,967

SYSTEMS AND METHODS FOR RADIATION DETECTION WITH IMPROVED EVENT TYPE DISCRIMINATION

PERKINELMER HEALTH SCIENC...

1. A method for quantifying two or more kinds of radionuclides present in a test sample, the method comprising:for each of a plurality of finite detected radioactive events in the test sample, obtaining, by a processor of a computing device, a measure of pulse shape, where the measure is a function of pulse intensity and pulse duration;
sorting, by the processor, each of the finite detected radioactive events according to its measure of pulse shape into one of at least three categories using distinct first and second discriminator settings, where the event is identified as originating from a first kind of radionuclide if its measure of pulse shape has a value below the first discriminator setting, the event is identified as originating from a second kind of radionuclide if its measure of pulse shape has a value above the second discriminator setting, and the event is identified as indeterminate if its measure of pulse shape has a value between the first and second-discriminator settings; and
displaying, by the processor, a measure of the first kind of radionuclide and a measure of the second kind of radionuclide.
US Pat. No. 10,068,063

METHODS AND APPARATUS FOR IDENTIFICATION OF POLYMERIC SPECIES FROM MASS SPECTROMETRY OUTPUT

PerkinElmer Health Scienc...

1. A method for identifying a species of an unidentified chemical compound, the method comprising:accessing, by a processor of a computing device, mass spectrometry data for a sample comprising the unidentified chemical compound;
identifying, by the processor, at least a first candidate chemical formula for the unidentified chemical compound based at least in part on the mass spectrometry data;
determining, by the processor, the first candidate chemical formula is a neutral loss match to the unidentified chemical compound, said determining of the neutral loss match comprising, for each of a plurality of spectral peaks of the mass spectrometry data:
calculating a respective mass difference between a theoretical mass of the first candidate chemical formula and a respective experimental mass corresponding to the spectral peak, and
comparing the respective mass difference with a mass of each of one or more corresponding neutral molecular compositions to identify one or more candidate neutral molecular compositions corresponding to the spectral peak.

US Pat. No. 10,187,967

TORCHES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A system for sustaining an atomization source, the system comprising:a torch comprising a hollow cylindrical outer tube comprising an entrance end within a first section of the outer tube and an exit end within a second section of the outer tube, in which the torch is configured to desolvate sample at the first section of the outer tube and to sustain an atomization source within the second section of the outer tube, wherein the first section of the outer tube and the second section of the outer tube are coupled to each other through at least one material, and in which the exit end of the outer tube comprises a lanthanide or actinide material present in an effective length and an effective amount to prevent degradation of the exit end of the torch, in which the first section of the outer tube comprises a non-refractory material, and wherein the at least one material coupling the first section of the outer tube and the second section of the outer tube is different than the non-refractory material of the first section and the at least one lanthanide or actinide material of the exit end of the outer tube; and
an induction device comprising an aperture configured to receive the torch and provide radio frequency energy to the torch to sustain the atomization source in the body of the torch.

US Pat. No. 10,184,921

GAS CHROMATOGRAPH COLUMN CONNECTION DEVICE

PerkinElmer Health Scienc...

1. A column connection apparatus comprising:a column base within which a column is movably disposed, the column base comprising a column retainer, a column tab, and a column biasing mechanism;
a depressible release slider positioned with respect to the column base and in communication with the column tab;
wherein the column retainer and the column tab define a space therebetween in which the column is slideably disposed, and wherein the column biasing mechanism urges the column tab toward the column retainer to frictionally engage the column between the column tab and the column retainer, thereby inhibiting movement of the column within the column base;
wherein depressing the release slider reduces the column tab's frictional engagement with the column, thereby reducing inhibition of movement of the column within the column base;
a housing and sealing assembly surrounding the column, the sealing assembly comprising a piston, a piston biasing mechanism, a piston retainer at the piston's first end, and a ferrule at the piston's second end; and
wherein the piston retainer and piston biasing mechanism urge the piston toward its second end such that, when abutting a mating portion of an external device, the ferrule forms a first seal around the column.

US Pat. No. 10,136,869

SYSTEMS AND METHODS FOR CHARACTERIZING A CENTRAL AXIS OF A BONE FROM A 3D ANATOMICAL IMAGE

PerkinElmer Health Scienc...

1. A method comprising:receiving, by a processor of a computing device, a 3-D image of one or more bones, comprising at least a portion of a bone of interest, of a mammal;
isolating, by the processor, the bone of interest from the one or more bones in the 3-D image;
generating, by the processor, a binary bone mask of the bone of interest;
generating, by the processor, a filled bone mask for the bone of interest using the binary bone mask;
generating, by the processor, a skeleton of the bone of interest by 3D thinning to produce a plurality of branches that include a branch corresponding to a 3-D central axis representing a medial path through the bone of interest; and
generating, by the processor, a pruned skeleton comprising the branch corresponding to the 3-D central axis.

US Pat. No. 10,103,013

COLLISION CELLS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A mass spectrometer comprising:an ion source;
an ion detector; and
at least one ion collision cell fluidically coupled to the ion source at an entrance section of the ion collision cell and fluidically coupled to the ion detector at an exit section of the ion collision cell, the ion collision cell comprising a sectioned quadrature rod assembly configured to provide a collision section between the entrance section and the exit section, the sectioned quadrature rod assembly comprising first, second, third, and fourth pole segments in each region of the quadrature rod assembly, and a lens between segments of at least one of the entry section and the exit section, wherein the lens is coupled to and in contact with two adjacent regions of the sectioned quadrature rod assembly, wherein the lens comprises an aperture and a plurality of separate conductive elements disposed on each side of the lens, in which a respective disposed conductive element on each side of the lens contacts and is configured to electrically couple to one of the first, second, third, and fourth pole segments of the sectioned quadrature rod assembly to permit an RF field to continue at a pole/lens interface.

US Pat. No. 10,147,592

SPRAY CHAMBERS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A spray chamber configured to couple to a nebulizer at an inlet end to receive a liquid sample from the nebulizer and provide an aerosolized sample spray at an outlet end to an ionization device, the spray chamber comprising: an outer chamber comprising the inlet end, the outlet end and dual makeup gas inlet ports each configured to receive a gas to provide a tangential gas flow within the outer chamber; and an inner tube within the outer chamber, the inner tube comprising a plurality of internal microchannels configured to receive makeup gas introduced into the outer chamber from the dual makeup gas inlets, in which the inner tube is sized and arranged to provide a laminar flow between an outer surface of the inner tube and an inner surface of the outer chamber to reduce droplet deposition on the inner tube.

US Pat. No. 10,368,427

PLASMAS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A device comprising:a torch body;
an inductive device surrounding the torch body and configured to provide inductively coupled radio frequency energy into the torch body; and
at least one capacitive device separate from the inductive device and positioned between a first end of the inductive device and an end of the torch body, wherein the capacitive device is configured to provide capacitively coupled radio frequency energy into the torch body simultaneously with the provided inductively coupled radio frequency energy from the inductive device to sustain a plasma within the torch body.

US Pat. No. 10,327,319

COUNTERFLOW SAMPLE INTRODUCTION AND DEVICES, SYSTEMS AND METHODS USING IT

PerkinElmer Health Scienc...

1. A system comprising:a torch configured to sustain an inductively coupled plasma in the torch, wherein the torch comprises a single gas inlet in an outer body of the torch, wherein the torch is configured to introduce a plasma gas through the single gas inlet in a flow that is substantially parallel to a longitudinal axis of an outer body of the torch, wherein the single gas inlet is positioned at a first end of the torch;
an induction device comprising an aperture configured to receive the torch and configured to provide radio frequency energy into the torch to sustain the inductively coupled plasma in the torch; and
a sample introduction device fluidically coupled to the torch and configured to provide a sample fluid flow to the torch in a direction that opposes the flow of the plasma gas in the torch that is used to sustain the inductively coupled plasma to introduce analyte in the sample fluid flow into the sustained inductively coupled plasma to ionize the introduced analyte, wherein the sample introduction device is configured to introduce the sample flow into the torch at a second end of the torch that is opposite the first end of the torch.

US Pat. No. 10,178,982

SYSTEM AND METHODS FOR AUTOMATED SEGMENTATION OF INDIVIDUAL SKELETAL BONES IN 3D ANATOMICAL IMAGES

PerkinElmer Health Scienc...

1. A method of performing image segmentation to automatically differentiate individual organs in an image of a subject, the method comprising:receiving, by a processor, a gray-scale image of a subject;
applying, by the processor, a plurality of second derivative splitting filters to the image to produce split organ masks for the image based on each second derivative splitting filter;
combining the split organ masks for the image produced by each second derivative splitting filter into a hybrid split organ mask for the image, using one or more logical operations;
determining, by the processor, a plurality of split binary components of the hybrid split organ mask by performing one or more morphological processing operations; and
performing, by the processor, a region growing operation using the split binary components of the hybrid split organ mask as seeds, thereby producing a segmentation map differentiating individual organs in the image.

US Pat. No. 10,181,394

SYSTEMS AND METHODS FOR AUTOMATED OPTIMIZATION OF A MULTI-MODE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER

PerkinElmer Health Scienc...

1. A system for automated optimization (tuning) of a multi-mode inductively coupled plasma mass spectrometer (ICP-MS), the system comprising:a plasma gas source;
an inductively coupled plasma torch (ICP torch) and RF coil for generating a plasma in which an analyte sample is introduced and from which an ion beam exits;
a vacuum chamber into which the ion beam enters, wherein the vacuum chamber comprises a mass analyzer and detector for detection and/or quantification of analyte ionic species in the analyte sample; and
a controller for carrying out an automated optimization routine, wherein the controller is operatively connected to a computer-readable medium comprising instructions, that, when executed, cause a processor to:
receive user data input regarding an optimization to be performed on the ICP-MS for tuning of components of the ICP-MS for accurate detection and/or quantification of analyte ionic species in the analyte sample, wherein the user data input comprises an identification of one or more selected modes of operation in which the ICP-MS is to be operated;
receive a user input for initiating an automated optimization routine for the tuning of components of the ICP-MS for accurate detection and/or quantification of analyte ionic species in the analyte sample; and
following receipt of the user input for initiating the routine, transmit a first signal to the controller,
wherein the first signal, when received, causes the controller to perform the automated optimization routine for the tuning of components of the ICP-MS, wherein the automated optimization routine comprises an ICP-MS performance assessment subsequence, said subsequence comprising the steps of
(a) automatically conducting a first performance assessment comprising a preliminary evaluative check of instrument sensitivity, said preliminary evaluative check comprising comparing a sensitivity of a measurement of a calibration standard solution by the ICP-MS to predetermined instrument performance specifications, then,
(i) responsive to a determination, by the processor, that the first performance assessment is unsatisfactory, ending the ICP-MS subsequence and identifying the ICP-MS performance assessment subsequence as failed, and
(ii) responsive to a determination, by the processor, that the first performance assessment is satisfactory, conducting a second performance assessment, wherein the first performance assessment contains fewer steps and is less time consuming to conduct than the second performance assessment, then
 (A) responsive to a determination, by the processor, that the second performance assessment is unsatisfactory, ending the ICP-MS subsequence and identifying the ICP-MS performance assessment subsequence as failed, and
 (B) responsive to a determination, by the processor, that the second performance assessment is satisfactory, ending the subsequence and identifying the ICP-MS performance assessment subsequence as passed,
wherein the instructions cause the processor, responsive to an identification of the ICP-MS performance assessment subsequence is as failed, to transmit a second signal to the controller, identifying the ICP-MS performance assessment subsequence as failed and tuning of the ICP-MS as being needed, wherein the second signal, when received by the controller, causes the controller to perform the tuning of the components of the ICP-MS, wherein the tuning comprises automatic adjustment of the ICP torch per an optimization subroutine, wherein the optimization subroutine comprises automatically adjusting an alignment of an X-Y position of the ICP torch relative to an ion optics assembly of the ICP-MS, wherein the X-Y position of the ICP torch corresponds to vertical and horizontal settings of the ICP torch.

US Pat. No. 10,375,811

ASYMMETRIC INDUCTION DEVICES AND SYSTEMS AND METHODS USING THEM

PerkinElmer Health Scienc...

1. A device for generating a plasma in a torch body with a longitudinal axis along which a flow of gas is introduced during operation of the torch body, the device comprising a plurality of induction coils comprising at least three coils coupled to each other and forming an aperture configured to receive a portion of the torch body, in which the at least three coils comprise a first coil coupled to a second coil and a third coil coupled to the second coil to provide an induction coil winding configured to receive the torch body in the formed aperture, wherein longitudinal spacing along a longitudinal direction substantially parallel to the longitudinal axis of the torch body between at least two of the first coil, the second coil and the third coil is asymmetric in the longitudinal direction.

US Pat. No. 10,375,810

CAPACITIVELY COUPLED DEVICES AND OSCILLATORS

PerkinElmer Health Scienc...

1. A method of sustaining a capacitively coupled plasma comprising:introducing a gas flow into a torch body comprising alumina, wherein the gas flow comprises helium gas; and
providing radio frequency energy to the torch body using a capacitive device configured to sustain the capacitively coupled plasma in the torch body comprising the alumina, in which the capacitive device contacts an external surface of the torch body, wherein the capacitive device comprises a wire coil comprising a plurality of coils coupled to each other and positioned external to and coiled around the torch body with the wire coils forming an aperture that receives the torch body, in which the wire coil is configured to couple to an oscillator at a first end of the wire coil to provide the radio frequency energy and contacts the external surface of the torch at a second terminal end of the wire coil to provide capacitive coupling to the torch.

US Pat. No. 10,290,478

DETECTORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. An electron multiplier comprising a plurality of dynodes, in which at least two dynodes of the plurality of dynodes are each electrically coupled to a respective electrometer, in which the electron multiplier is configured to split a beam into a first beam and a second beam, in which the electron multiplier is electrically coupled to a first processor configured to measure a non-saturated analog signal, using the first beam, from one of the at least two dynodes electrically coupled to its respective electrometer, in which the electron multiplier is configured to count pulses, using the second beam, to provide a pulse count signal and in which the first processor is configured to cross-calibrate the measured non-saturated analog signal with the pulse count signal to provide a calibration curve.

US Pat. No. 10,462,890

INDUCTION DEVICES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A system for sustaining an ionization source, the system comprising:a torch comprising a body comprising a longitudinal axis along which a flow of gas is introduced during operation of the torch; anda plate electrode comprising an inner aperture constructed and arranged to receive a body of the torch and a radial fin coupled to the plate electrode, in which the plate electrode is configured to provide radio frequency energy to the body of the torch to sustain the ionization source within the torch.

US Pat. No. 10,309,939

CHROMATOGRAPHY SYSTEMS AND METHODS USING THEM

PerkinElmer Health Scienc...

1. A system for modulating flow of a fluid in a chromatography system, the system comprising:a microfluidic device fluidically coupled to a switching valve, in which the microfluidic device comprises a first charging chamber and a second charging chamber; and
a detector fluidically coupled to a first outlet of the microfluidic device,
wherein the switching valve is configured to actuate between a first position and a second position, wherein the first position is configured to permit fluid flow from a modulating gas source to the first charging chamber of the microfluidic device to provide column effluent from the first charging chamber to the detector fluidically coupled to the microfluidic device, and wherein the second position is configured to permit fluid flow from the modulating gas source to the second charging chamber of the microfluidic device to provide column effluent from the second charging chamber to the detector fluidically coupled to the microfluidic device.

US Pat. No. 10,262,850

INORGANIC AND ORGANIC MASS SPECTROMETRY SYSTEMS AND METHODS OF USING THEM

PERKINELMER HEALTH SCIENC...

1. A system comprising:an ionization core configured to receive a sample and provide both inorganic ions and organic ions using the received sample; and
a mass analyzer fluidically coupled to the ionization core, in which the mass analyzer comprises at least one mass spectrometer core configured to select (i) ions from the inorganic ions received from the ionization core and (ii) ions from the organic ions received from the ionization core, in which the mass analyzer is configured to select the inorganic ions and the organic ions with a mass as low as three atomic mass units and up to a mass as high as two thousand atomic mass units.

US Pat. No. 10,247,710

BACKFLUSH METHODS AND DEVICES FOR CHROMATOGRAPHY

PerkinElmer Health Scienc...

1. A kit comprising:a microfluidic device comprising a laminated wafer body comprising an input port, a first outlet port and a second outlet port, in which each of the first outlet port and the second outlet port is fluidically coupled to the input port through an internal microchannel within the laminated wafer body, the microfluidic device configured to provide a sample from the input port to the first outlet port and to the second outlet port;
a first fluid flow path fluidically coupled to the first outlet port of the microfluidic device to receive the sample from the first outlet port, wherein the first fluid flow path comprises a first restrictor configured to be fluidically coupled to a pressure source;
a second fluid flow path fluidically coupled to the second outlet port of the microfluidic device to receive the sample from the second outlet port, wherein the second fluid flow path comprises a second restrictor configured to be fluidically coupled to a second pressure source; and
instructions for using the microfluidic device, the pressure source and the second pressure source to backflush the sample in the second fluid flow path to the first fluid flow path through the laminated wafer body of the microfluidic device.

US Pat. No. 10,229,820

OPTICAL DETECTORS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A method of detecting optical emission, the method comprising:simultaneously detecting an input current signal at each dynode of a plurality of dynodes of a photomultiplier configured to receive photons, in which each dynode is electrically coupled to a processor; and
using the processor to average the detected input current signals at each dynode that comprises a measured current input signal above a noise current input signal and below a saturation current input signal to determine a mean input current.

US Pat. No. 10,470,286

TORCHES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A method of reducing degradation of a torch configured to sustain an atomization source, the method comprising providing a torch comprising a hollow cylindrical outer tube comprising an entrance end and an exit end, in which the torch is configured to desolvate sample at the entrance end of the torch and to sustain an atomization source within the exit end of the torch, in which the entrance end and the exit end of the torch are coupled to each other through at least one material, in which the entrance end of the torch comprises a non-refractory material, and in which a terminal end of the exit end of the torch comprises at least one refractory material, and wherein material at the entrance end of the torch is different than material at the terminal end of the torch and different than the at least one material that couples the exit end of the torch and the entrance end of the torch.

US Pat. No. 10,395,905

ION DETECTORS AND METHODS OF USING THEM

PERKINELMER HEALTH SCIENC...

1. A detector comprising an electron multiplier comprising a plurality of dynodes each electrically coupled to a respective electrometer, wherein each dynode-electrometer pair is electrically coupled to a first processor configured to simultaneously detect input and output current signals at each dynode of the plurality of dynodes, and wherein the first processor is configured to average detected input current signals at each dynode with a detected current input signal above a noise current input signal and below a saturation current input signal to determine a mean electron multiplier input current.

US Pat. No. 10,381,210

DOUBLE BEND ION GUIDES AND DEVICES USING THEM

PerkinElmer Health Scienc...

1. A device comprising:a first multipole comprising a plurality of electrodes comprising a first electrode, a second electrode, a third electrode and a fourth electrode, wherein the first electrode, the second electrode, the third electrode and the fourth electrode are spatially separated from each other and each is electrically coupled to a power source configured to provide a direct current voltage to each of the first, second, third and fourth electrodes to provide a DC electric field effective to direct first ions of an entering particle beam along a first internal trajectory within the first multipole and within an inner space formed by the first electrode, the second electrode, the third electrode and the fourth electrode that is substantially orthogonal to an entry trajectory of the particle beam, in which the first electrode, the second electrode, the third electrode and the fourth electrode are further configured to direct the directed, first ions along a second internal trajectory within the first multipole and within the inner space formed by first electrode, the second electrode, the third electrode and the fourth electrode that is substantially orthogonal to the first internal trajectory; and
a processor electrically coupled to each of the first electrode, the second electrode, the third electrode and the fourth electrode and the power source, wherein the processor is configured to provide the direct current voltage independently to each of the first electrode, the second electrode, the third electrode and the fourth electrode to provide the DC electric field and to direct the first ions of the entering particle beam along the first internal trajectory that is substantially orthogonal to the entry trajectory of the particle beam and along the second internal trajectory that is substantially orthogonal to the first internal trajectory.

US Pat. No. 10,399,030

FLUIDIC DEVICES AND METHODS FOR MODULATING FLOW OF FLUID IN CHROMATOGRAPHY SYSTEM TO PROVIDE TREE WAY SWITCHING

PerkinElmer Health Scienc...

1. A method of switching between a plurality of inlet fluids in a chromatography system to provide three way switching, the method comprising independently actuating first and second switching valves each fluidically coupled to a laminated wafer body microfluidic device, the laminated wafer body microfluidic device further fluidically coupled to at least three separate input fluid flows at three separate ports on the laminated wafer body, in which a position of the first switching valve and a position of the second switching valve provides an output flow from an output port of the laminated wafer body microfluidic device from one input fluid flow of the at least three separate input fluid flows.

US Pat. No. 10,395,912

SPRAY CHAMBERS AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A method of analyzing inorganic or organic species in single cells in a cell population, the method comprising:introducing a cell population into a spray chamber configured to couple to a nebulizer at an inlet end to receive a liquid sample from the nebulizer and provide an aerosolized sample spray at an outlet end to an ionization device, the spray chamber comprising an outer chamber comprising the inlet end, the outlet end and dual makeup gas inlet ports each configured to receive a gas to provide a tangential gas flow within the outer chamber, and an inner tube within the outer chamber, the inner tube comprising a plurality of internal microchannels configured to receive makeup gas introduced into the outer chamber from the dual makeup gas inlets, wherein the inner tube is sized and arranged to provide a laminar flow between an outer surface of the inner tube and an inner surface of the outer chamber to reduce droplet deposition on the inner tube;
selecting a single cell from the introduced cell population;
spraying the selected single cell from the spray chamber and into an ionization device to analyze the inorganic or organic species in the selected single cell; and
detecting at least one inorganic or organic species in the sprayed, selected single cell.

US Pat. No. 10,379,089

THERMAL GRADIENT CHROMATOGRAPHY DEVICES AND METHODS OF USING THEM

PerkinElmer Health Scienc...

1. A gas chromatography system comprising:a heating device configured to thermally couple to an inlet section of a gas chromatography column in a first position and to thermally couple to an exit section of the gas chromatography column in a second position, wherein the inlet section of the gas chromatography column is configured to receive a gaseous analyte mixture, wherein the gas chromatography column comprises a separation medium to separate the gaseous analyte mixture using gas chromatography, and wherein separated analytes exit from the gas chromatography column at the exit end of the gas chromatography column, the heating device configured to move longitudinally along the gas chromatography column from the first position to the second position during a gas chromatographic separation wherein the heating device is configured as a cylinder configured to move through an interior space formed by the gas chromatography column; and
a processor configured to control movement of the heating device longitudinally along the gas chromatography column from the first position to the second position during the gas chromatographic separation using the heating device to provide a thermal gradient to the gas chromatography column during the gas chromatographic separation.

US Pat. No. 10,431,444

SYSTEMS AND METHODS FOR AUTOMATED ANALYSIS OF OUTPUT IN SINGLE PARTICLE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY AND SIMILAR DATA SETS

PerkinElmer Health Scienc...

1. A method for automated analysis of spectrometry data the method comprising:(a) accessing, by a processor of a computing device, a sequence of pulse count values acquired by a spectrometer to produce, for each of at least one given peak corresponding to particles comprising an analyte and being present in a sample, pulse count values being greater than a threshold background intensity value;
(b) determining, by the processor, from a first array of the pulse count values, a threshold for identifying pulse count values as corresponding to a peak signal, and adjusting the threshold based on remaining pulse count values following each of a series of iterations, with a given subsequent iteration including pulse count values not identified as corresponding to a peak in a preceding iteration, wherein a final background threshold is determined upon convergence of the threshold within acceptable tolerance;
(c) building, by the processor, from the first array of the pulse count values, a smoothed data array comprising smoothed values and identifying, as identified peaks, a subset of the smoothed values that are larger than both subsequent and preceding smoothed values of the smoothed data array and also larger than the final background threshold; and
(d) automatically determining, by the processor, based on the identified peaks, at least one of:
(A) a particle mass distribution and/or particle size distribution for the particles in the sample; and
(B) statistical data for the particles in the sample.

US Pat. No. 10,453,666

RF ION GUIDE WITH AXIAL FIELDS

PerkinElmer Health Scienc...

1. An apparatus, comprising:an ion source;
a mass analyzer;
a RF ion guide positioned in an ion path between the ion source and the mass analyzer, the RF ion guide having an ion guide axis extending between an input end of the RF ion guide and an exit end of the RF ion guide, the RF ion guide comprising:
a first rectilinear electrode extending along the ion guide axis, the first electrode configured to be connected to a voltage source, and
a second rectilinear electrode extending along the ion guide axis, the second electrode configured to be connected to a RF source, a portion of the second electrode being positioned between the first electrode and the ion guide axis, the second electrode defining a longitudinal elongated slot extending through a plane of the second electrode, wherein during use of the apparatus, the RF ion guide produces RF electric fields within a central portion of the RF ion guide throughout a region between the second electrode and the ion guide axis to radially confine ions,
wherein the first electrode comprises a first face and a second face adjacent to the first face, the first face and the second face extending parallel to the ion guide axis, the first face having a greater surface area than the second face, the first face disposed beyond the plane of the second electrode and facing the ion guide axis,
wherein the first and second electrodes are configured so that during operation of the apparatus, a DC electric field is generated between the first and second electrodes to provide a DC electric field at the ion guide axis that has a non-zero axial component throughout at least a portion of the length of the RF ion guide.