US Pat. No. 9,808,538

PSMA-TARGETED NIR DYES AND THEIR USES

On Target Laboratories, L...

1. A method of optical imaging of a biological tissue that expresses PSMA, the method comprising:
(a) contacting the biological tissue with a composition a compound having the formula: B—X—Y—Z, wherein
B comprises a compound capable of binding to prostate specific membrane antigen (PSMA),
X, is selected from the group consisting of polyethylene glycol (PEG), N-amino-dPEG2-acid and polyethylene amine (PEA),
Y comprises at least one amino acid, or derivative thereof, and
Z comprises a near-infra red (NIR) dye,
(b) allowing time for the compound in the composition to distribute within the biological target;
(c) illuminating the tissue with an excitation light of a wavelength absorbable by the compound; and
(d) detecting the optical signal emitted by the compound.
US Pat. No. 9,801,956

PSMA-TARGETED NIR DYES AND THEIR USES

On Target Laboratories, L...

1. A compound having the formula:
B-X-Y-Z,wherein
B comprises a compound capable of binding to prostate specific membrane antigen (PSMA),
X is selected from the group consisting of polyethylene glycol (PEG), N-amino-dPEG2-acid and polyethylene amine (PEA),
Y comprises at least one amino acid, or derivative thereof, and
Z comprises a near-infra red (NIR) dye.
US Pat. No. 9,968,691

PSMA-TARGETED NIR DYES AND THEIR USES

On Target Laboratories, L...

1. A compound having a formula: B-X-Y-Z, whereinB comprises DUPA or a derivative thereof;
X is EAOA,
Y is selected from the group consisting of phenylalanine-tyrosine, histidine-tyrosine, phenylalanine-arginine-tyrosine, and histidine-tyrosine;
and Z comprises S0456.

US Pat. No. 10,308,606

PSMA-TARGETED NIR DYES AND THEIR USES

On Target Laboratories, L...

1. A method for synthesizing a compound of the formula:
wherein n is 0, 1, 2, 3, or 4;
further wherein R3, R4, and R5 are independently selected from the group consisting of H+, Na+, K+, and NH4+; R6, R7, R8, and R9 are independently selected from the group consisting of H+, Na+, K+, and NH4+; and R10H+;
comprising the steps of:
(a) reacting a compound of formula I:

with a compound of formula:

in the presence of a polar organic solvent, 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate and N,N-Diisopropylethylamine under argon and
(b) reacting the resulting compound with sodium carbonate and a dye compound of the formula

US Pat. No. 10,456,482

PSMA—TARGETED NIR DYES AND THEIR USES

On Target Laboratories, L...

1. A compound selected from the group consisting of:

US Pat. No. 10,557,854

CA IX—NIR DYES AND THEIR USES

On Target Laboratories, L...

1. A compound having the formula:B-W-X-Y-Z
wherein B is a CA IX-targeted molecule is selected from the group consisting of

wherein n is 0, 1, 2, 3 . . . ; m is 0, 1, 2, 3, 4, 5, . . . and p is 0, 1, 2, 3, . . . ;
W is an extended hydrophobic residue;
X is a hydrophobic spacer;
Y is an amino acid spacer; and
Z is a NIR dye.

US Pat. No. 10,746,741

CA IX—NIR DYES AND THEIR USES

On Target Laboratories, L...

1. A kit comprising:a first compound having the formula:
B—W—X—Y—Zwherein B is a CA IX-targeted molecule is selected from the group consisting ofwherein n is 0, 1, 2, or 3; m is 0, 1, 2, 3, 4, or 5 and p is 0, 1, 2, or 3;W is an extended hydrophobic residue;
X is a hydrophobic spacer;
Y is an amino acid spacer; and
Z is a NIR dye; and
a second compound, wherein the second compound comprises a pteroyl ligand conjugated to an amino acid linking group or a PSMA-targeting compound conjugated to an amino acid linking group.

US Pat. No. 10,676,487

SYNTHESIS AND COMPOSITION OF PHOTODYNAMIC THERAPEUTIC AGENTS FOR THE TARGETED TREATMENT OF CANCER

On Target Laboratories, L...

1. A compound having the formula:
or a pharmaceutically acceptable salt thereof, or isotopes thereof, wherein
L is an amino acid,
L/ is a linker to improve pharmacokinetic properties,
L// is a linker which may be configured to release an organelle-targeted photodynamic therapeutic (PDT) agent,
X is an organelle-targeting agent, and
Y is a photodynamic therapeutic agent selected from the group consisting of:

US Pat. No. 10,786,580

CHOLECYSTOKININ 2 RECEPTOR TARGETED NIR IMAGING AND USE THEREOF

On Target Laboratories, L...

1. A compound having the formula B-L-Zwherein B is a targeting ligand capable of selectively binding to CCK2R and/or CCK2i4svR selected from the group consisting of

wherein the values of m and n are independently selected from the values 0, 1, or 2,
wherein L is a linker selected from the group consisting of glutamic acid,

and
wherein Z is an imaging agent represented by the formula:

wherein, R1 is independently selected from the group consisting of O, S, N and C, R2 is independently selected from the group consisting of CH2 and CH2CH2, and each of R3, R4, and R5 are independently selected from the group consisting of H, Na, K, and NH4 or a salt thereof, or isotopes thereof wherein L enhances the binding affinity and biodistribution of the compound.