US Pat. No. 9,494,224

CIRCULAR WAVE DRIVE

Ohio State Innovation Fou...

1. A circular wave drive, comprising:
an enclosed housing having a chamber therein,
wherein the periphery of the chamber is defined by a circular wall,
wherein the circular wall includes an inner diameter, and
wherein the circular wall includes a friction element;
a ring-shaped wheel residing in the chamber,
wherein the ring-shaped wheel includes both an external friction element and an internal friction element,
wherein the ring-shaped wheel includes a hollow central portion including an inner wall having an inner diameter, the inner
wall including the internal friction element,

wherein the inner wall of the ring-shaped wheel is axially divided into a non-friction element portion and a friction element
portion,

wherein the ring-shaped wheel includes an outer diameter, and
wherein the ring-shaped wheel outer diameter is less than the inner diameter of the circular wall;
a wave generator having a wheel-driving portion that is oriented within the hollow central portion of the ring-shaped wheel,
wherein the wave generator includes an eccentrically mounted input shaft extending from the wheel-driving portion and through
the housing;

an output element having a wheel-driven portion that is oriented within the hollow central portion of the ring-shaped wheel
opposite the wheel-driving portion of the wave generator,

wherein the output element includes an output shaft that extends from the wheel-driven portion and through the housing in
an opposite direction of the input shaft of the wave generator, and

wherein a peripheral face of the wheel-driven portion includes a friction element being in contact with the internal friction
element of the ring-shaped wheel; and

a bearing having an inner race and an outer race, wherein a peripheral surface of the wheel-driving portion of the wave generator
is connected to the inner race of the bearing, and wherein the non-friction element portion of the inner wall of the ring-shaped
wheel is connected to the outer race of the bearing.

US Pat. No. 9,113,640

COATED SHELL EGGS AND METHOD OF MAKING SAME

Ohio State Innovation Fou...

1. A shell egg, comprising:
a shell having an outer surface;
a coating covering a portion of said outer surface, said coating comprising a food grade natural resin, wherein said coating
extends in a band around said shell egg.

US Pat. No. 9,796,967

COMPOSITIONS RELATED TO CONTROLLABLE INTERVENING PROTEIN SEQUENCES (CIPS) COMPRISING REVERSIBLE ZINC-BINDING MOTIFS AND INTEINS

Ohio State Innovation Fou...

1. A modified peptide comprising a controllable intervening protein sequence (CIPS), wherein the modified peptide comprises
the structure:
X1-CIPS

wherein X1 is an affinity tag, wherein the CIPS comprises the amino acid sequence of a reversible zinc-binding motif and an intein, wherein
the reversible zinc-binding motif is appended to the N-terminus of the intein, and wherein the reversible zinc-binding motif
comprises G-E-G-H (SEQ ID NO: 1) or G-D-G-H (SEQ ID NO: 2).

US Pat. No. 9,164,080

SYSTEM AND METHOD FOR SENSING NO

Ohio State Innovation Fou...

1. An NO sensing system for measuring NO in a breath sample, the system comprising:
an inlet configured to receive the breath sample as it is exhaled by a subject;
a humidifier fluidly communicating with the inlet and configured to humidify the breath sample as it transmits the breath
sample through the humidifier to a humidifier outlet, such that the breath sample exits the humidifier outlet as a humidified
sample having a humidity above a predetermined level; and

a sensing element comprising a plurality of sensors electrically coupled together, each of the plurality of sensors configured
to generate a potential difference in response to presence of NO in the humidified sample;

wherein the plurality of sensors comprises an effective number of sensors coupled together such that a combined potential
difference of the plurality of sensors can indicate a level of NO less than about 100 ppb in the breath sample.

US Pat. No. 9,872,374

LIQUID THIN-FILM LASER TARGET

Ohio State Innovation Fou...

1. A laser target comprised of:
a liquid film creation device, wherein said liquid film creation device is configured to form a liquid laser target comprised
of a liquid crystal material.

US Pat. No. 9,804,423

ON-CHIP OPTICAL POLARIZATION CONTROLLER

Ohio State Innovation Fou...

1. An optical polarization controller, comprising:
a substantially planar substrate; and
a waveguide unit cell formed on the substantially planar substrate, the waveguide unit cell comprising:
a first out-of-plane waveguide portion, and
a second out-of-plane waveguide portion coupled to the first out-of-plane waveguide portion, wherein each of the first and
second out-of-plane waveguide portions respectively includes a core material layer arranged between a first optical cladding
layer having a first stress-response property and a second optical cladding layer having a second stress-response property
that is different than the first stress-response property such that each of the first and second out-of-plane waveguide portions
is deflected by a deflection angle, wherein the deflection angle of at least one of the first out-of-plane waveguide portion
or the second out-of-plane waveguide portion is configured to be adjustable in response to an electrical excitation, and wherein
the at least one of the first out-of-plane waveguide portion or the second out-of-plane waveguide portion further comprises
a piezoelectric actuator layer provided on the first or second optical cladding layers, the piezoelectric actuator layer being
configured to expand or contract in response to an applied electric field.

US Pat. No. 9,260,484

SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS

Ohio State Innovation Fou...

1. A compound comprising (a) a protein binding moiety and (b) an effector region, wherein said protein binding moiety binds
to a blocking protein, and wherein said effector region binds to a target protein, and further wherein the protein binding
moiety is:

wherein R1 is D-?-homoPhe; R2 is L-Thr; R3 is L-Ala; and R4 is L-Ala.

US Pat. No. 9,593,138

NITRILE-CONTAINING ENZYME INHIBITORS AND RUTHENIUM COMPLEXES THEREOF

Wayne State University, ...

1. A compound of Formula IA:
wherein
Ru is ruthenium;
each L2 is a protease inhibitor having a —C?N—bonded to Ru through the nitrogen of the —C?N—, wherein the protease inhibitor is a
cysteine protease inhibitor, a cathepsin protease inhibitor, a serine protease inhibitor, or an aspartic protease inhibitor;
or

one L2 is a protease inhibitor having a —C?N—bonded to Ru through the nitrogen of the —C?N—, wherein the protease inhibitor is a
cysteine protease inhibitor, a cathepsin protease inhibitor, a serine protease inhibitor, or an aspartic protease inhibitor,
and the other L2 is a solvent molecule coordinated to ruthenium;

each L1 is independently a nitrogen-containing ruthenium ligand, optionally connected to one or more other L1 groups to form a multidentate ruthenium ligand or a solvent molecule;

wherein one L1 group optionally forms a monodentate ligand, two L1 groups optionally form a bidentate ruthenium ligand, three L1 groups optionally form a tridentate ruthenium ligand, or four L1 groups optionally form a tetradentate ruthenium ligand; and

n[anion]m is a pharmaceutically acceptable anion where n is 2 and m is ?1, or n is 1 and m is ?2.

US Pat. No. 9,146,293

METHODS AND APPARATUS FOR ACCURATE CHARACTERIZATION OF SIGNAL COIL RECEIVER SENSITIVITY IN MAGNETIC RESONANCE IMAGING (MRI)

Ohio State Innovation Fou...

1. A method for estimating receiver coil sensitivity in a magnetic resonance (MR) system, the method comprising:
estimating a transmit field of a transceiver coil from signal intensity images acquired by the MR system;
determining a transverse electromagnetic field B_xy of the transceiver coil using at least one phase image;
determining a receiver sensitivity of the transceiver coil using the transmit field and transverse electromagnetic field;
using the transceiver coil as a reference coil for estimating a coil sensitivity of a second receiver coil; and
estimating a receiver coil sensitivity using a reference method with the estimated receive sensitivity of the transceiver
coil.

US Pat. No. 9,481,885

METHODS AND COMPOSITIONS RELATED TO MIR-21 AND MIR-29A, EXOSOME INHIBITION, AND CANCER METASTASIS

Ohio State Innovation Fou...

1. A method to inhibit metastasis of at least one cancer cell in a subject having lung cancer, comprising decreasing the levels
of expressions of miR-21 and/or miR-29a in exosomes from the lung cancer cell,
wherein expression level of miR-21 and/or miR-29a is decreased via administration of at least one exosome inhibitor selected
from the group consisting of: an antisense miR-21 exosome inhibitor, and an antisense miR-29a exosome inhibitor; and,

wherein the at least one exosome inhibitor is administered in an amount sufficient to inhibit metastasis of the at least one
cancer cell in the subject.

US Pat. No. 9,156,790

ANTICANCER P21-ACTIVATED KINASE INHIBITORS

Ohio State Innovation Fou...

1. A compound according to formula I:

wherein Ar is 3-phenanthrene, R1 is selected from —C(?O)NH-isopropyl and CF3and R2 is selected from —C(?O)CH2NH2and —C(?O)CH2CH2NH2, and pharmaceutically acceptable salts thereof.

US Pat. No. 9,550,160

METHODS FOR PRODUCING NANOPARTICLES AND USING SAME

Ohio State Innovation Fou...

1. A nanocomposite particle comprising:
a micelle comprising an amphiphile and a hydrophobic core and a surfactant, where the surfactant is poly(vinyl alcohol);
at least one first hydrophobic quantum dot encapsulated in the hydrophobic core of the micelle, the first quantum dot having
a first emission wavelength;

at least one second hydrophobic quantum dot encapsulated in the hydrophobic core of the micelle, the second quantum dot having
a second emission wavelength that is different from the first emission wavelength; and

the nanocomposite particle having a diameter in a range of about 5 nm to about 1000 nm.

US Pat. No. 9,364,787

WET SCRUBBER APPARATUS FOR AMMONIA CAPTURE

Ohio State Innovation Fou...

1. A device for removing a substance from a gas stream by spraying a liquid into said gas stream, said device comprising:
a plurality of conduits for dividing said gas stream into a plurality of separate gas streams, said conduits being substantially
unobstructed to permit flow of said separate gas streams therethrough without significant resistance;

at least one spray nozzle positioned in each said conduit for spraying said liquid into each of said separate gas streams
thereby subjecting said entire gas stream to said liquid while passing through said conduits.

US Pat. No. 9,217,721

NO SENSOR AND SENSOR SYSTEMS

Ohio State Innovation Fou...

1. A sensor device for sensing NO, the sensor device comprising:
a sensing element including:
a first region consisting of WO3;

a second region consisting of Cr2O3;

at least a first electrode established within the first region;
at least a second electrode established within the second region; and
wiring interconnecting the first and second electrodes;
wherein the first region is adjacent to and contacts the second region; and
wherein a measured resistance along the wiring is indicative of the presence of NO in a gas interlacing with the sensing element.

US Pat. No. 9,809,810

GALVANOTAXIS ASSAY FOR QUANTITATIVE ASSESSMENT OF THE METASTATIC POTENTIAL OF CANCER CELLS

Ohio State Innovation Fou...

1. A method for controlling cell migration comprising the steps of:
providing an electromagnetic coil having a first end and a second end;
connecting the electromagnetic coil to a function generator;
applying a time-varying voltage waveform to the electromagnetic coil;
inducing a time-varying electric field around the electromagnetic coil;
placing the electromagnetic coil adjacent to, and without contacting, the location of cancer cells;
directing the induced electric field along an axis of migration of the cancer cells;
orientating the placement of the electromagnetic coil to control the direction of the induced electric field; and
reducing the migration of the cancer cells using the induced electric field.

US Pat. No. 9,402,891

NOROVIRUS IMMUNOGENS AND RELATED MATERIALS AND METHODS

Ohio State Innovation Fou...

1. A live recombinant vesicular stomatitis virus (VSV)-vector vaccine composition for a human norovirus, the composition comprising
a virus encoding a foodborne viral immunogen inserted between glycoprotein and polymerase genes of a VSV genome, wherein the
foodborne viral immunogen is a major capsid protein of a norovirus, or an immunogenic fragment thereof;
wherein the insertion attenuates or eliminates VSV virulence,
wherein the encoded foodborne virus immunogen forms a virus-like particle (VLP) when the norovirus immunogen is expressed,
and

wherein the VLP is capable of being formed in vivo subsequent to norovirus immunogen expression from the VSV-vector vaccine
composition.

US Pat. No. 9,339,239

METHODS AND DEVICES FOR OPTIMIZATION OF MAGNETIC RESONANCE IMAGING PROTOCOLS

Ohio State Innovation Fou...

1. A method for optimizing k-space strategies for MR acquisition, comprising:
setting independent image parameters, wherein the independent image parameters are independent of a k-space strategy in an
imaging sequence;

simulating, using a computing device, at least one respective image quality metric for each of a plurality of k-space acquisitions,
wherein the image quality metric comprises a contrast metric;

optimizing the k-space strategy, wherein optimizing the k-space strategy comprises using the simulated image quality metrics
for each of the k-space acquisitions to select a sampling order in k-space center that maximizes the contrast metric and minimizes
an image artifact caused by the k-space strategy; and

acquiring at least one MR image using the optimized k-space strategy, wherein selecting a sampling order in k-space center
further comprises:

filling a k-space zero line using a k-space acquisition having a maximum contrast metric, wherein the contrast metric comprises
at least one of a contrast, contrast efficiency, CNR or CNR efficiency, and

designing the sampling order to minimize the image artifact caused by the k-space strategy, wherein the image artifact caused
by the k-space strategy comprises at least one of signal inhomogeneity, SNR inhomogeneity, contrast inhomogeneity, CNR inhomogeneity,
signal loss, geometry distortion or image ghost.

US Pat. No. 9,176,111

BIOLOGICAL CELL SEPARATOR AND DISPOSABLE KIT

Ohio State Innovation Fou...

1. A disposable kit for directing a fluid sample of biological cells through a separator device and collecting separated cells
from the sample, the kit comprising:
a sample receiving container including an inlet and an outlet, the inlet coupled with an inlet conduit for receiving a buffer
fluid and the outlet coupled with an outlet conduit, the outlet conduit comprising a first section and a second section;

a separator tube including an inlet end and an outlet end, the inlet end coupled with the outlet conduit from the sample receiving
container, the separator tube having:

a length defining a separation channel;
a diameter adapted for operable communication with a magnet along the length of the separation channel;
a space for receiving a flow of the buffer fluid and sample, and wherein a length of the second section of the outlet conduit
from the sample receiving container is oriented along a path defined by the separator tube and adapted to allow displacement
of the magnet from a separation position to an idle position while the flow of fluid is maintained;

a separated cell container having an inlet port and a vacuum port,
a separated cell conduit coupled for fluid communication between the outlet end of the separator tube and the inlet port of
the separated cell container,

a flushing fluid container having an inlet port and a vacuum port; and
a flushing conduit coupled for fluid communication between the outlet end of the separator tube and the inlet port of the
flushing fluid container.

US Pat. No. 9,144,678

APPARATUS, SYSTEMS, AND METHODS FOR TREATING BODY ORGAN AGING

OHIO STATE INNOVATION FOU...

1. A method for treating body organ aging in a mammal, the method comprising the steps of:
identifying a mammal suffering from or afflicted by dysfunction or degeneration of at least one organ as result of organ aging;
placing a therapy delivery device into electrical communication with an autonomic nervous system (ANS) nerve target and/or
a central nervous system (CNS) nerve target associated with the at least one target organ; and

activating the therapy delivery device to deliver the therapy signal to the ANS nerve target and/or the CNS nerve target in
an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity associated with the
at least one target organ;

wherein the body organ aging is caused by dysfunction of the ANS, the CNS or both.
US Pat. No. 9,452,204

CHIMERIC PEPTIDES COMPRISING HER-2 B-CELL EPITOPES AND TCELL HELPER EPITOPES

Ohio State Innovation Fou...


US Pat. No. 9,271,955

NUTRITIONAL SUPPLEMENTS FOR EYE HEALTH AND RELATED METHODS

Ohio State Innovation Fou...

1. A nutrition supplement composition for an eye comprising on a daily dosage basis: approximately 0.5-5 mg copper, as copper
glycinate, approximately 12-50 mg zinc, as zinc glycinate, approximately 100-500 IU natural vitamin E and high-absorption
phospholipidated lutein.

US Pat. No. 9,170,225

OBTAINING SELECTIVITY IN GAS SENSORS VIA A SENSOR ARRAY SYSTEM COMPOSED OF P AND N TYPE MATERIAL

Ohio State Innovation Fou...

1. A sensor system comprising:
a sensing element including:
a p-type MOS material, and
an n-type MOS material discrete from the p-type MOS material and contacting the p-type MOS material at a diffuse p-n junction;
a plurality of electrode wires, including a first electrode wire connecting spaced electrodes in the p-type MOS material,
a second electrode wire connecting spaced electrodes in the n-type MOS material, and a third electrode wire connecting an
electrode in the p-type MOS material and an electrode in the n-type MOS material; and

a controller programmed to determine a measured resistance across each of the first, second, and third electrode wires when
the sensing element is exposed to a sample gas, estimate a null point from the measured resistances, and identify an analyte
in the sample gas based on a statistical comparison of the measured resistances with a stored calibration database.

US Pat. No. 9,153,060

METHOD FOR ESTIMATING A GRAPPA RECONSTRUCTION KERNEL

Ohio State Innovation Fou...

1. A method of determining a k-space convolution kernel in Generalized Auto-calibrating Partially Parallel Acquisitions (GRAPPA)
reconstruction of magnetic resonance imaging, comprising:
acquiring plural frames of 2-D images or 3-D images at a same slice location (2-D) or slab location (3-D);
acquiring k-space data of the plural frames of 2-D images or 3-D images;
providing at least two sets of auto-calibration signal (ACS) lines from the acquired k-space data;
utilizing a number of linear equations to estimate the k-space convolution kernel that is greater than a number of linear
equations that could be derived from one set of ACS lines; and

wherein the linear equations are a linear regression to at least two sets of ACS lines to estimate the k-space convolution
kernel,

wherein the linear regression is defined by the relationship:
AG=b,
wherein an m×n matrix A is the input of the GRAPPA reconstruction or other k-space based reconstructions, wherein each row
of the matrix A represents a sliding window in k-space, m is the number of reconstructed k-space points/sliding window, wherein
G is a vectorized GRAPPA kernel with size n×1, and wherein b is a vectorized output of the GRAPPA reconstruction with size
m×1.

US Pat. No. 9,561,477

METHODS FOR SYNTHESIZING MICROPOROUS CRYSTALS AND MICROPOROUS CRYSTAL MEMBRANES

Ohio State Innovation Fou...

12. A method of making a microporous crystal membrane, comprising:
a. forming a mixture comprising NaOH, water, and one or more of an aluminum source, a silicon source, and a phosphate source,
whereupon the mixture forms a gel;

b. heating the gel for a first time period, whereupon a first volume of water is removed from the gel and microporous crystal
nuclei form, the nuclei having a framework; and

c. applying the gel to a solid support seeded with microporous crystals having a framework that is the same as the framework
of the nuclei;

d. heating the gel for a second time period, during which a second volume of water is added to the gel; wherein the rate of
addition of the second volume of water is between about 0.5 and about 2.0 fold the rate of removal of the first volume of
water.

US Pat. No. 9,757,432

MATERIALS AND METHODS USEFUL FOR TREATING GLIOBLASTORNA

Ohio State Innovation Fou...

1. A method to induce cell death in at least one glioblastoma cancer cell, comprising:
a) administering from about 0.55 ?M to about 17.5 ?M of a SapC-DOPS composition to at least one glioblastoma cancer cell;
and,

b) administering from about 1 nM to about 50 nM of a rapamycin compound to the at least one glioblastoma cancer cell;
the SapC-DOPS composition and rapamycin compound being present in amounts sufficient for inducing cell death in the at least
one glioblastoma cancer cell;

wherein the SapC-DOPS composition comprises:
a phospholipid comprising dioleoylphosphatidylserine (DOPS);
an isolated saposin C-related polypeptide consisting of SEQ ID NO:2;
and a pharmaceutically acceptable carrier;
wherein the rapamycin compound comprises sirolimus; and,
wherein the DOPS phospholipid forms a nanovesicle incorporating the saposin C-related polypeptide.
US Pat. No. 9,603,873

ACTIVATION OF INNATE IMMUNITY BY MIRNA FOR CANCER AND INFECTION TREATMENT

OHIO STATE INNOVATION FOU...

1. A method of treating a subject that has an infection or cancer disease comprising:
delivering miR-155 into NK cells to create miR-155 tg NK cells, wherein the miR-155 tg NK cells overexpress miR-155;
stimulating the miR-155 tg NK cells with an interleukin; and
transferring the stimulated miR-155 tg NK cells into the subject having the disease to treat the disease.
US Pat. No. 9,441,275

POLYMORPHISM IN CYP3A4 GENE AFFECTING DRUG METABOLIZING AND USES THEREOF

Ohio State Innovation Fou...

1. A method of administering a statin dose to a human, comprising:
obtaining a nucleic acid-containing test sample from a human, wherein the human is in need of statin therapy;
conducting at least one genotyping assay of the sample so as to obtain at least the genotype data at position rs35599367 of
CYP3A4 in the sample, wherein the at least one genotyping assay comprises hybridizing a tagged primer to DNA in the nucleic
acid-containing test sample, amplifying the hybridized DNA and detecting the tagged primer;

detecting a T allele at position rs35599367 of CYP3A4; and
administering a statin dose to the human comprising a TT or TC genotype at position rs35599367 of CYP3A4 of less than 20 mg
per day wherein the statin administered is a statin that depends on CYP3A4 for elimination.

US Pat. No. 9,746,654

OPTICAL DELAY ELEMENTS CREATED FROM VARIATIONS OF THE ROBERT CELL

OHIO STATE INNOVATION FOU...

1. An optical delay device comprising:
a multi-pass optical cell including a first curved mirror and a second curved mirror facing the first curved mirror to define
an optical cavity;

wherein the second curved mirror includes a wedge shaped notch aperture formed into the perimeter of the second curved mirror
via which an input light beam passes through the second curved mirror, and the multi-pass optical cell is configured to provide
a selectable optical time delay based on the location in the wedge shaped notch aperture at which the input light beam passes
through the second curved mirror.

US Pat. No. 9,368,676

GD DOPED ALGAN ULTRAVIOLET LIGHT EMITTING DIODE

OHIO STATE INNOVATION FOU...

1. An apparatus comprising:
a diode comprising nanowires that are compositionally graded along their lengths and that include an active region sandwiched
between first and second compositionally graded AlxGa1-xN nanowire regions wherein:

the active region is doped with gadolinium,
the first compositionally graded AlxGa1-xN nanowire region is compositionally graded from gallium-rich AlxGa1-xN to aluminum-rich AlxGa1-xN with the compositional grading defining n-type polarization doping and with the aluminum-rich AlxGa1-xN end proximate to the active region, and

the second compositionally graded AlxGa1-xN nanowire region is compositionally graded from aluminum-rich AlxGa1-xN to gallium-rich AlxGa1-xN with the compositional grading defining p-type polarization doping and with the aluminum-rich AlxGa1-xN end proximate to the active region.

US Pat. No. 9,343,810

METHOD OF MAKING AN EXTREMELY LOW PROFILE WIDEBAND ANTENNA

Ohio State Innovation Fou...

1. A method for designing an ultra low-profile VHF antenna, said method comprising:
providing a ground plane;
providing a ferrite loading;
providing a conductive plate having a first end and a second end; and
associating said ground plane, said ferrite loading, and said conductive plate such that said ferrite loading is positioned
between said ground plane and said conductive plate, said first end of said conductive plate is shorted to said ground plane,
and said second end of said conductive plate is adapted to be placed in electrical communication with an antenna feed.

US Pat. No. 9,174,951

GLUCOSE TRANSPORTER INHIBITORS

OHIO STATE INNOVATION FOU...

1. A compound according to formula I:

wherein R1-R5 are selected from the group consisting of hydrogen, C1-C4 alkyl, halogen, hydroxyl, nitro, amine, C1-C4 alkoxy, and trifluoromethyl;

R6 is selected from the group consisting of hydrogen, halogen, and C1-C4 alkyl;

and R7 and R8 are trifluoromethyl;

and pharmaceutically acceptable salts thereof.

US Pat. No. 9,777,920

OXYGEN CARRYING MATERIALS

OHIO STATE INNOVATION FOU...

1. An oxygen carrying material comprising:
about 20% to about 70% by weight of a primary active mass, the primary active mass comprising a composition having a metal
or metal oxide selected from the group consisting of Fe, Co, Ni, Cu, Mo, Mn, Sn, Ru, Rh, and combinations thereof;

about 5% to about 70% by weight of a primary support material, the primary support material comprising a composition having:
(i) at least one metal, metal oxide, metal carbide, metal nitrate, or metal halide, wherein the at least one metal, metal
oxide, metal carbide, metal nitrate, or metal halide comprises metal elements selected from the group consisting of Li, Be,
B, Na, Mg, Al, Si, K, Ca, Sc, Ti, V, Cr, Mn, Co, Zn, Ga, Ge, Rb, Sr, Y, Zr, Nb, Mo, Cd, In, Sn, Sb, Cs, Ba, La, Ce, Th, and
combinations thereof;

(ii) at least one ceramic or clay material, or salts thereof;
(iii) at least one naturally occurring ore; or
(iv) combinations thereof; and
about 1% to about 35% by mass of a secondary support material, the secondary support material comprises a composition having
at least one metal, metal oxide, metal carbide, metal nitrate, or metal halide of Mg,

wherein the primary support material composition and the secondary support material composition are different.
US Pat. No. 9,738,709

METHYLATED PEPTIDES DERIVED FROM TAU PROTEIN AND THEIR ANTIBODIES FOR DIAGNOSIS AND THERAPY OF ALZHEIMER'S DISEASE

Ohio State Innovation Fou...

1. A method comprising:
a. obtaining a test biological sample from an individual, the test biological sample being chosen from cerebrospinal fluid,
blood, serum, and plasma;

b. quantifying the amounts of a methylated tau protein in the test biological sample obtained in step a, said methylation
occurring on one or more lysine residues, wherein said quantifying of said methylated tau protein is achieved via use of an
antibody to a methylated peptide derived from tau protein;

c. comparing the amounts of methylated tau protein in the test biological sample with the amounts present in a control biological
sample from a subject without Alzheimer's disease;

d. diagnosing Alzheimer's disease, or predisposition thereto, based on a difference in the amount of the methylated tau protein
in the test biological sample as compared to the control biological sample; and

e. administering to the individual a composition chosen from:
i. a composition having at least one antigenic tau peptide linked to an immunogenic carrier, wherein the antigenic tau peptide
is monomethylated on one or more lysines, and wherein the one or more monomethylated lysines are numbered according to the
human tau isoform with NCBI accession number NP_005901and include one or more of the following residues: 24, 44, 163, 174,
180, 254, 267, 281, 290, 311, 317, 340, 353, 369, and 395; and

ii. a composition having at least one antibody to an antigenic tau peptide including at least one monomethylated lysine epitope
numbered according to the human tau isoform with NCBI accession number NP_005901and including one or more of the following
residues: 24, 44, 163, 174, 180, 254, 267, 281, 290, 311, 317, 340, 353, 369, and 395.

US Pat. No. 9,457,074

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME

Ohio State Innovation Fou...

1. A composition comprising an inactivated porcine reproductive and respiratory syndrome virus (PRRSV) entrapped within a
nanoparticle, wherein the composition further comprises an adjuvant, wherein the adjuvant comprises a Mycobacterium lysate.

US Pat. No. 9,490,280

MINIATURE PHASE-CORRECTED ANTENNAS FOR HIGH RESOLUTION FOCAL PLANE THZ IMAGING ARRAYS

Ohio State Innovation Fou...

1. A method of correcting optical aberration for an off-axis detector of a millimeter-wave/terahertz sensor system, comprising:
providing a hemispherical lens having a focal plane opposite to a curvature of the hemispherical lens, the focal plane being
extended away from a center of the hemispherical lens, the center of the hemispherical lens defining an optical axis; and

providing one or more wideband detectors positioned near the focal plane of the hemispherical lens, each of the one or more
detectors respectively comprising an antenna and a sensor element coupled to the antenna; and

correcting for optical aberrations of at least one of the one or more wideband detectors that is offset by a distance from
the optical axis of the hemispherical lens by tilting a radiating pattern of the respective antenna of the at least one of
the one or more wideband detectors offset by the distance from the optical axis of the hemispherical lens by an angle and
directing the tilted radiation pattern toward the optical axis of the hemispherical lens, wherein a maximum direction of the
radiating pattern of the respective antenna of the at least one of the one or more wideband detectors is related to the distance
by which the at least one of the one or more wideband detectors is offset from the optical axis of the hemispherical lens.

US Pat. No. 9,371,227

INTEGRATION OF REFORMING/WATER SPLITTING AND ELECTROCHEMICAL SYSTEMS FOR POWER GENERATION WITH INTEGRATED CARBON CAPTURE

Ohio State Innovation Fou...

1. A method for producing electricity and a separate CO2 rich stream from a carbonaceous fuel and steam comprising:
reducing Fe2O3 containing particles to lower oxidation state metallic iron containing particles by reacting the Fe2O3 containing particles with a carbonaceous fuel in a first reaction zone, the first reaction zone having a top and a bottom;

oxidizing a first portion of the metallic iron containing particles with a steam or CO2 rich gas from a fuel cell anode in a second reaction zone to provide iron oxide containing particles while generating a fuel
rich gas stream comprising H2 or CO;

returning the fuel rich gas stream from the second reaction zone to the anode of the fuel cell via a closed loop between the
second reactor zone and the fuel cell, wherein the closed loop comprises a working fluid stream of (1 ) fuel and (2 ) steam
or CO2;

directly sending a second portion of the metallic iron containing particles from the first reaction zone to a third reaction
zone, and oxidizing the second portion of the metallic iron containing particles and iron oxide containing particles obtained
from the oxidation reaction in the second reaction zone with an oxygen containing gas to produce Fe2O3 containing particles in a third reaction zone; and

returning the Fe2O3 containing particles to the first reaction zone;

wherein at least a portion of the oxygen containing gas used in the third reaction zone is the oxygen containing gas produced
from the outlet of a fuel cell cathode.

US Pat. No. 9,364,668

APPARATUS, SYSTEMS, AND METHODS FOR TREATING BODY ORGAN AGING

Ohio State Innovation Fou...

1. A method for treating body organ aging in a mammal, the method comprising the steps of:
determining the level of at least one physiological parameter associated with ANS and/or CNS activity in at least one target
organ of the mammal;

predicting dysfunction or degeneration in the at least one target body organ by comparing the determined level of the at least
one physiological parameter with a control value;

placing a therapy delivery device into electrical communication with an ANS nerve target and/or CNS nerve target associated
with the at least one target organ in a mammal having an abnormal level of the at least one physiological parameter; and

activating the therapy delivery device to deliver the therapy signal to the ANS nerve target and/or the CNS nerve target in
an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity associated with the
at least one target organ.

US Pat. No. 9,833,416

OLIGONUCLEOTIDE LIPID NANOPARTICLE COMPOSITIONS, METHODS OF MAKING AND METHODS OF USING THE SAME

OHIO STATE INNOVATION FOU...

1. A composition for inhibiting miRNA activity in vitro or in vivo in a cell, comprising at least one oligonucleotide encapsulated
in a lipid nanoparticle;
the lipid nanoparticle being comprised of a combination of permanently ionized quaternary amine-cationic lipids and conditionally
ionized tertiary amine-cationic lipids; the lipid nanoparticle having a formulation comprising at least:

quaternary amine 1,2-dioleoyl-3-dimethylammonium-propane (DOTAP);
tertiary amine 1,2-dioeyloxy-N,N-dimethyl-3-aminopropane (DODMA);
neutral lipid 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC);
helper lipid cholesterol (CHOL); and,
PEGylating agent N-(carbonyl-methoxypolyethyleneglycol 2000)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE-PEG),
wherein DOTAP and DODMA each constitute 40 mol percent of the total amount of lipids in the composition, and/or
wherein the lipids in the composition consist of DOTAP, DODMA, DOPC, CHOL, and PEG-DPPE present in respective molar ratios
of 15:25:36:20:4; and,

the oligonucleotide having a negatively charged phosphate or phosphorothioate backbone capable of having electrostatic interactions
mediated by the cationic lipids present in the lipid nanoparticle.

US Pat. No. 9,808,758

WET SCRUBBER APPARATUS FOR AMMONIA CAPTURE

Ohio State Innovation Fou...

1. A device for removing a substance from a gas stream by spraying a liquid into said gas stream, said device comprising:
at least one conduit, said conduit being substantially unobstructed to permit flow of said gas stream therethrough without
significant resistance, said conduit having a first and a second end, said first end of said conduit being in fluid communication
with the atmosphere; and

a plurality of spray nozzles positioned in said conduit for spraying said liquid into said gas stream thereby subjecting said
entire gas stream to said liquid while passing through said conduit.

US Pat. No. 9,502,716

ROBUST PLATINUM-COPPER CATALYSTS

Ohio State Innovation Fou...

1. A population of platinum-copper (PtCu) nanoparticles comprising a
(a) a particle interior comprising platinum and copper; and
(b) a surface layer comprising platinum surrounding the particle interior,
wherein the nanoparticles have an average particle size of from 60 nm to 500 nm, as determined by scanning electron microscopy
(SEM).

US Pat. No. 9,427,460

USE OF MIR-494 TO MODULATE TRAIL-INDUCED APOPTOSIS THROUGH BIM DOWN-REGULATION

Ohio State Innovation Fou...

1. A method to inhibit down-regulation of Bcl-2-like protein 11 (BIM) in a TRAIL-resistant cancer cell that over-expresses
miR-494, comprising administering an effective amount of at least one inhibitor of miR-494 to the cancer cell and inhibiting
BIM down-regulation.

US Pat. No. 9,783,513

STAT3 INHIBITORS AND THEIR ANTICANCER USE

Ohio State Innovation Fou...

1. A compound having a structure represented by a formula:

wherein R1 is selected from hydrogen and C1-C3 alkyl;

wherein Q1 is —NR2aR2b and wherein Q2 is O; or wherein Q1 and Q2 are together N;

wherein each of R2a and R2b, when present, is independently selected from hydrogen and C1-C3 alkyl;

wherein Q3 is selected from —(C1-C6)-Ar1, Ar1, —(C1-C6)-Cy1, and Cy1;

wherein Ar1, when present, is selected from phenyl, naphthyl, monocyclic heteroaryl, and bicyclic heteroaryl; and wherein Ar1 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —CN, —OH, —NH2, —NO2, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 hydroxyalkyl, C1-C6 monoalkylamino, C1-C6 dialkylamino, —(C1-C6)NR4aR4b, —(C1-C6)-(C?O)R3, —(C1-C6)-(C?O)OR3, —(C1-C6)-(C?O)NR4aR4b, —(C1-C6)-Ar2, Ar2, —(C1-C6)-Cy2, Cy2, and —S(O)nNR5aR5b;

wherein n is 0, 1, or 2;
wherein each R3, when present, is independently selected from hydrogen, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 hydroxyalkyl,
and C1-C6 aminoalkyl;

wherein each of R4a and R4b, when present, is independently selected from hydrogen, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 hydroxyalkyl,
and C1-C6 aminoalkyl;

wherein each of R5a and R5b, when present, is independently selected from hydrogen, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 hydroxyalkyl,
C1-C6 aminoalkyl, and —(C?O)NR6aR6b;

wherein each of R6a and R6b, when present, is independently selected from hydrogen and C1-C6 alkyl;

wherein each Ar2, when present, is independently selected from is phenyl and monocyclic heteroaryl; and wherein Ar2 is substituted with 0,
1, 2, or 3 groups independently selected from halogen, —CN, —OH, —NH2, —NO2, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 monoalkylamino, and C1-C6
dialkylamino;

wherein each Cy2, when present, is independently selected from C3-C8 cycloalkyl and C2-C7 heterocycloalkyl; and wherein Cy2 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —CN, —OH, —NH2, —NO2, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 hydroxyalkyl, C1-C6 aminoalkyl, C1-C6 monoalkylamino, C1-C6
dialkylamino, —(C?O)R7, —(C?O)OR7, —(C?O)NR8aR8b, —(C?O)-(C1-C6 alkyl)Ar3, —(C?O)—O—(C1-C6 alkyl)Ar3, and —(C?O)—NR8a—(C1-C6 alkyl)Ar3;

wherein each R7, when present, is independently selected from hydrogen, C1-C6 alkyl, C1-C6 monohaloalkyl, and C1-C6 polyhaloalkyl;

wherein each of R8a and R8b, when present, is independently selected from hydrogen, C1-C6 alkyl, C1-C6 monohaloalkyl, and C1-C6 polyhaloalkyl;

wherein each Ar3, when present, is independently selected from phenyl and monocyclic heteroaryl substituted with 0, 1, 2, or 3 groups independently
selected from halogen, —CN, —OH, —NH2, —NO2, C1-C6 alkyl, C1-C6 monohaloalkyl, and C1-C6 polyhaloalkyl;

wherein Cy1, when present, is selected from C3-C8 cycloalkyl and C2-C7 heterocycloalkyl; and wherein Cy1 is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —CN, —OH, —NH2, —NO2, C1-C6 alkyl, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 hydroxyalkyl, C1-C6 monoalkylamino, C1-C6 dialkylamino, —(C1-C6)NR4aR4b, —(C1-C6)-(C?O)R3, —(C1-C6)-(C?O)OR3, —(C1-C6)-(C?O)NR4aR4b, —(C1-C6)-Ar2, Ar2, —(C1-C6)-Cy2, Cy2, and —S(O)nNR5aR5b;

or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,044,432

COMPOSITIONS AND METHODS FOR CANCER DETECTION AND TREATMENT

Ohio State Innovation Fou...

1. A pharmaceutical composition comprising a therapeutically effective amount of the compound of formula
wherein R1 is:

A1, A2, A3, A4, and A5 are each individually hydrogen, halo, alkyl, alkoxyl, —OH, —NH2, or —NO2;

A15 is C1-C6 alkyl; or a salt thereof;

in combination with a pharmaceutically suitable carrier.

US Pat. No. 9,791,396

SPACE ADAPTIVE RECONSTRUCTION TECHNIQUE FOR ADAPTIVE ELECTRICAL CAPACITANCE VOLUME TOMOGRAPHY

TECH4IMAGING LLC, Columb...

1. A system for tomographic imaging in a pipe, tube or other object comprising:
a sensor, comprising at least four electrodes, positioned in a predetermined arrangement relative to each other around the
pipe, tube, or object; each of the electrodes comprising a plurality of capacitance plate segments, each of the capacitance
plate segments of each of the electrodes defining a capacitor when paired with a corresponding capacitance plate segment of
one of the other electrodes;

a voltage source, arranged to impart a voltage to selected capacitance plate segments, a sensitivity of the sensor being controlled
by at least one of: the amount and the distribution of the imparted voltage applied to the selected capacitance plate segments;

a measuring circuit, connected to each of the at least four electrodes to detect a capacitance of any of the capacitors between
any selected pair of the electrodes though currents induced in the measuring circuit; and

a first processing system, in communication with the measuring circuit, the first processing system programmed with instructions
for executing on the first processing system to: 1) convert capacitance data collected therefrom into an image; 2) analyze
information provided by an image reconstruction of a peripheral region of an imaging domain of the sensor; and 3) provide
control signals to the sensor to increase the resolution at a center region of the imaging domain of the sensor based on the
prior image reconstruction of the peripheral region; 4) obtain image reconstruction information for the center region of the
imaging domain; and 5) combine the image reconstruction information for the peripheral region and the center region to obtain
a combined image of the imaging domain.

US Pat. No. 9,757,213

HYBRID DENTAL IMPLANT

Ohio State Innovation Fou...

1. A hybrid dental implant comprising:
a dental implant body having an external thread on an external surface of the dental implant body, the dental implant body
having a length of 15.0 mm or less and a diameter of 5.0 mm or less,

the dental implant body comprising an upper portion with an open ceiling, a middle portion having a hollow inner channel,
and a lower portion with a closed floor;

the hollow inner channel comprising
a) one portion connected to the open ceiling, which is configured to receive one or more injectable bone inducing agents;
b) a lower portion terminating at the closed floor; and
c) one or more side openings extending from the hollow inner channel, rotating in a helix-like shape in an opposing direction
from that of a plurality of turns of the external thread, wherein the dimensions of the side openings are of sizes designed
to enable bone ingrowth into the hollow inner channel and bone outgrowth from the hollow inner channel to the surrounding
bone.

US Pat. No. 9,616,403

SYSTEMS AND METHODS FOR CONVERTING CARBONACEOUS FUELS

Ohio State Innovation Fou...

1. A system for converting carbonaceous fuels comprising a gaseous fuel conversion reactor, a solid fuel conversion reactor,
and a fuel pretreatment fluidized bed reactor disposed between the gaseous fuel conversion reactor and the solid fuel conversion
reactor;
the gaseous fuel conversion reactor comprising:
a gaseous fuel reactor oxygen carrier solid inlet,
a gaseous fuel reactor off-gas inlet configured to receive off-gas from the fuel pretreatment fluidized bed reactor, and
a gaseous fuel reactor oxygen carrier solid outlet,
wherein the gaseous fuel conversion reactor is configured to convert the off-gas and oxygen carrier solids to a product gas
stream comprising carbon dioxide and water, thereby reducing at least a portion of the oxygen carrier solids to reduced oxygen
carrier solids;

the fuel pretreatment fluidized bed reactor comprising:
a pretreatment reactor solid fuel inlet disposed in a fuel introduction section of the fuel pretreatment reactor,
a pretreatment reactor oxygen carrier inlet configured to receive a mixture of oxygen carrier solids and reduced oxygen carrier
solids from the gaseous fuel reactor oxygen carrier solid outlet,

a pretreatment reactor intermediate gas inlet configured to receive intermediate gas from the solid fuel conversion reactor,
the intermediate gas being used for fluidization, and

a pretreatment reactor discharge in communication with the gaseous fuel conversion reactor off-gas inlet,
wherein the fuel pretreatment fluidized bed reactor is configured to volatilize solid fuel using heat from the mixture of
oxygen carrier solids and reduced oxygen carrier solids to produce a devolatilized solid fuel and off-gas, and subsequently
discharge the off-gas, the devolatilized solid fuel, and the mixture of oxygen carrier solids and reduced oxygen carrier solids
via the pretreatment reactor discharge;

the solid fuel conversion reactor comprising:
a solid fuel conversion reactor inlet configured to receive the mixture of oxygen carrier solids and reduced oxygen carrier
solids and devolatilized solid fuel from the pretreatment reactor discharge and

a solid fuel conversion reactor intermediate gas outlet in communication with the pretreatment reactor intermediate gas inlet,
and

a solid fuel conversion reactor oxygen carrier solid outlet,
wherein the solid fuel conversion reactor is configured to react the devolatilized solid fuel with the mixture of oxygen carrier
solids and reduced oxygen carrier solids to produce the intermediate gas comprising carbon dioxide and water, thereby further
reducing oxygen carrier solids to reduced oxygen carrier solids.

US Pat. No. 9,295,407

HYDRAULICALLY-POWERED SYSTEM AND METHOD FOR ACHIEVING MAGNETIC RESONANCE ELASTOGRAPHY

OHIO STATE INNOVATION FOU...

1. A system for inducing tissue vibration for magnetic resonance elastography, the system comprising:
a passive actuator component positionable proximate to a target tissue, the passive actuator component including a linearly
movable piston assembly enclosed in a housing such that alternating linear movement of the linearly movable piston causes
vibration of the passive actuator component and induces vibration of the target tissue when the passive actuator component
is positioned proximate to the target tissue;

a first hose coupled to the passive actuator on a first side of the piston assembly;
a second hose coupled to the passive actuator on a second side of the piston assembly opposite the first side; and
a driving component including a fluid pump, the driving component configured to alternatingly pump a fluid through the first
hose causing the piston assembly to move in a first linear direction and pump the fluid through the second hose causing the
piston assembly to move in a second linear direction, the second linear direction being opposite to the first linear direction,

wherein the passive actuator component further includes a displacement sensor configured to provide a signal to the driving
component indicative of a linear position of the piston assembly,

wherein the driving component is configured to
switch from pumping the fluid through the first hose to pumping the fluid through the second hose when the signal from the
displacement sensor indicates that the linear position of the piston assembly in the first linear direction meets or exceeds
a displacement threshold, and

switch from pumping the fluid through the second hose to pumping the fluid through the first hose when the signal from the
displacement sensor indicates that the linear position of the piston assembly in the second linear direction meets or exceeds
the displacement threshold, and

wherein the displacement sensor includes a fiber-optic displacement transducer.
US Pat. No. 9,750,819

LIPID NANOPARTICLE COMPOSITIONS AND METHODS OF MAKING AND METHODS OF USING THE SAME

Ohio State Innovation Fou...

1. A nanoparticle comprising:
a combination of tertiary and quaternary amine-based cationic lipids,
wherein said combination consists of the tertiary amine-cationic lipid present at about 40.0 molar percent; wherein the tertiary
amine-cationic lipid comprises N-[1-(2, 3-dioleyloyx) propyl]-N—N—N-dimethyl ammonium chloride (DODMA), and the concentration
of the quaternary amine cationic lipid present at about 5.0 molar percent;

and at least one single stranded oligonucleotide encapsulated within the lipid combination.

US Pat. No. 9,310,452

SELF-CONSTRAINT NON-ITERATIVE GRAPPA RECONSTRUCTION WITH CLOSED-FORM SOLUTION

Ohio State Innovation Fou...

1. A method of determining a Self-Constraint (SC) GeneRalized Autocalibrating Partially Parallel Acquisition (GRAPPA) reconstruction,
comprising:
sampling k-space data as a set of ACS lines acquired from a magnetic resonance imaging (MRI) apparatus;
estimating a GRAPPA kernel from the ACS lines;
estimating a null projection matrix N from the ACS lines;
performing a GRAPPA reconstruction to calculate k0, which represents the GRAPPA reconstruction;

calculating a k-space of the SC-GRAPPA in accordance with the GRAPPA reconstruction and a self-constraint condition defined
by local k-space correlations among acquired and unacquired k-space samples, the self-constraint condition being a set of
linear equations determined in accordance with correlations within missing k-space data, as follows:

k=k0+w, and

0=Nk+v,
wherein w and v are random noise terms, wherein k is vectorized local k-space data, and
wherein calculating the k-space of the SC-GRAPPA is performed in accordance with:
k=k0?RNT(Q+NRNT)?1Nk0,

wherein Q and R are covariance matrices of w and v, respectively; and
performing image reconstruction by transforming the k-space of the SC-GRAPPA into MRI image data that is displayed in a human
comprehensible format.

US Pat. No. 9,731,134

NEUROMODULATORY METHOD FOR TREATING CHRONIC OR REFRACTORY RHINITIS

Ohio State Innovation Fou...

1. A method for treating chronic or refractory rhinitis in a subject, said method comprising the steps of:
implanting a closed-loop therapy delivery system in the subject so that at least one therapy delivery component of the system
is positioned substantially adjacent a target location where modulation of the ANS is effective to treat chronic or refractory
rhinitis in a subject suffering therefrom, the therapy delivery component including at least one electrode configured to deliver
electric current to the target location;

delivering electric current to the at least one electrode to effect a change in the ANS;
sensing, by the therapy delivery system, of at least one physiological parameter associated with chronic or refractory rhinitis;
and

activating the therapy delivery component of the system to adjust application of electric current to the target site in response
to the sensed at least one physiological parameter to treat the chronic or refractory rhinitis in the subject.

US Pat. No. 9,540,936

LIQUID RING HEAT ENGINE

Ohio State Innovation Fou...

11. An improved liquid ring heat engine for extracting energy from a working fluid, comprising a cylindrical case, a rotor
having at least one vaned face mounted on a shaft that is eccentrically positioned in the case, a fluid in an internal space
of the case to provide a liquid piston when the rotor rotates on the shaft, the improved liquid ring heat engine comprising:
a first zone on the rotor where the working fluid is received into the first zone via a first conduit in the shaft and is
expanded;

a second zone on the rotor where the working fluid is compressed and said compressed working fluid exits the liquid ring heat
engine via a second conduit in the shaft;

an intermediate outlet from the first zone for the working fluid;
a cooler located external to the cylindrical case; and
an intermediate inlet to the second zone for the working fluid,
wherein the intermediate outlet, the cooler and the intermediate inlet define a conduit such that the working fluid exits
the first zone, passes through the cooler and enters the second zone, wherein energy to drive the liquid ring heat engine
are extracted from the working fluid.

US Pat. No. 9,216,390

SYSTEMS, COMPOSITIONS, AND METHODS FOR FLUID PURIFICATION

Ohio State Innovation Fou...

1. A membrane comprising:
a substrate;
a support layer on the substrate, the support layer comprising a plurality of pores;
a selective layer on the support layer, the selective layer having a plurality of substantially unconnected pores in fluid
communication with the pores of the support layer; and

a permeable layer on the selective layer,
wherein the support layer comprises a first polymer and the permeable layer comprises a second polymer, and
wherein the membrane has a CO2:N2 selectivity of at least 7.5 at 55° C. and 1.24 atm feed pressure.

US Pat. No. 10,030,273

MICRORNA EXPRESSION IN HUMAN PERIPHERAL BLOOD MICROVESICLES AND USES THEREOF

OHIO STATE INNOVATION FOU...

1. A method of diagnosing or prognosticating a colorectal cancer in a subject, comprising:i) isolating microvesicles from a sample from the subject;
ii) determining a level of at least one miR gene product in the microvesicles, wherein the at least one miR gene product comprises miR-19a, miR-21, miR-127, miR-31, miR-96, miR-135b, miR-183, miR-30c, miR-133a, miR-143, miR-133b or miR-145; and
iii) comparing the level of the at least one miR gene product in the sample to a control;
iv) detecting an increased level of the at least one miR gene product in the sample compared to the control, wherein the at least one miR gene product comprises miR-19a, miR-21, miR-127, miR-31, miR-96, miR-135b or miR-183, and/or
detecting a decreased level of the at least one miR gene product in the sample compared to the control, wherein the at least one miR gene product comprises miR-30c, miR-133a, miR-143, miR-133b, or miR-145;and
v) diagnosing or prognosticating colorectal cancer from the detected increased level of the at least one miR gene product that comprises miR-19a, miR-21, miR-127, miR-31, miR-96, miR-135b or miR-183, or from the decreased level of the at least one miR gene product that comprises miR-30c, miR-133a, miR-143, miR-133b, or miR-145.
US Pat. No. 9,504,738

IMMUNOGENIC EPITOPES, PEPTIDOMIMETICS, AND ANTI-PEPTIDE ANTIBODIES, AND METHODS OF THEIR USE

Ohio State Innovation Fou...

1. A composition comprising a VEGF peptide, wherein the VEGF peptide comprises ITMQCGIHQGQHPKIRMICEMSF (SEQ ID NO: 41), wherein
the two cysteine residues of the VEGF peptide are linked by a disulfide bond.

US Pat. No. 9,269,127

DE-NOISING OF REAL-TIME DYNAMIC MAGNETIC RESONANCE IMAGES BY THE COMBINED APPLICATION OF KARHUNEN-LOEVE TRANSFORM (KLT) AND WAVELET FILTERING

Ohio State Innovation Fou...

1. A method of providing a Karhunen-Love Transform Wavelet (KW) Filter to suppress random noise in an image series, comprising:
applying a Karhunen-Loeve Transform (KLT) to the image series to compress signal information into a finite set of frames,
the KLT being applied to a temporal domain to convert a temporal series of frames into a series of eigenimages having eigenvalues,
wherein the signal information is concentrated into a subset of eigenimages in accordance with their respective eigenvalues;

discarding substantially noise-only frames;
applying a Wavelet filter with an adaptive threshold to remaining frames; and
applying an inverse KLT to obtain the de-noised image series.

US Pat. No. 9,866,146

ENHANCED FLYBACK CONVERTER

OHIO STATE INNOVATION FOU...

1. A bidirectional direct-current-to-alternating-current (DC/AC) circuit, comprising:
a voltage source to supply an input voltage;
a first switch connected to the voltage source and a first capacitor;
a pair of second switches, wherein each switch of the pair of second switches is connected to the first capacitor and further
connected to a second capacitor such that the first capacitor and the second capacitor are separated by the pair of second
switches; and

a component connected to the first capacitor and the second capacitor, wherein the component is further coupled to a load;
wherein the first switch and the pair of second switches are selectively turned-on to define a plurality of modes of steady
state operation for the bidirectional DC/AC circuit within a switching period;

wherein, during a first mode of the plurality of modes of steady state operation, the first capacitor, the second capacitor,
and the component are connected in series, and are one of charged in series based on the input voltage and discharged in series;
and

wherein, during a second mode of the plurality of modes of steady state operation, the first capacitor and the second capacitor
are connected in parallel and are one of charged in parallel and discharged in parallel.

US Pat. No. 9,572,876

PARAMYXOVIRUS IMMUNOGENS AND RELATED MATERIALS AND METHODS

Ohio State Innovation Fou...

1. A recombinant paramyxovirus composition comprising a nucleic acid molecule which encodes large RNA polymerase (L) protein
having a defective mRNA cap MTase domain in a paramyxovirus viral genome, wherein the paramyxovirus viral genome is human
respiratory syncytial virus (hRSV); and,
wherein the nucleic acid molecule which encodes large RNA polymerase (L) protein having a defective mRNA cap MTase domain
carries at least one mutation in a S-adenosyl methionine (SAM) binding site;

wherein the at least one mutation in the SAM binding site is in a G×G×G . . . D/E/W site in an amino acid sequence corresponding
to amino acid positions 31-90 of SEQ ID NO: 3, wherein the mutations comprise:

at position 31, A×G×G . . . D;
at position 33, G×A×G . . . D;
at position 35, G×G×A . . . D; and,
at position 90, G×G×G . . . A.

US Pat. No. 9,782,176

COLLAPSIBLE ANVIL HEAD AND STAPLING APPARATUS

Ohio State Innovation Fou...

1. A surgical stapling apparatus comprising:
a handle;
a surgical staple dispensing head disposed adjacent a distal end of the handle; and
an anvil assembly disposed adjacent a distal end of the surgical staple dispensing head, the anvil assembly comprising:
at least two anvil plates that are separately formed from each other;
a plunger having a proximal end, a distal end, and a central portion there between, the plunger comprising a plunger head
at the distal end of the plunger, the plunger being translatable along a y-axis, the y-axis extending from a proximal end
of the handle to a distal end of the anvil assembly, and a portion of the central portion of the plunger extends through the
surgical staple dispensing head; and

a central anvil member comprising a hinge connector portion that is pivotably connected to the plunger head at a first point
and connected to a fixed hinge at a second point, the fixed hinge being separate from the plunger head, and the central anvil
member being configured to rotate about the second point between a tilted position and a transverse position, wherein in the
tilted position, a distal surface of the central anvil member is not parallel to a transverse plane extending perpendicularly
to the y-axis and, in the transverse position, the distal surface of the central anvil member is substantially parallel to
the transverse plane,

wherein the first point is offset from the y-axis and the second point is along the y-axis, and the plunger is translatable
downwardly along the y-axis for urging the central anvil member to rotate about the second point toward the transverse position
and is translatable upwardly along the y-axis for urging the central anvil member to rotate about the second point toward
the tilted position.

US Pat. No. 9,819,488

GENERATION OF ENCRYPTION KEYS BASED ON LOCATION

Ohio State Innovation Fou...

3. A method of generating an encryption key for use in electronic communications, the method comprising
transmitting, by an electronic processor of a first computing device, a beacon to a second computing device;
receiving, by the electronic processor, a response beacon from the second computing device;
determining, by the electronic processor, whether a third computing device is positioned such that the third computing device
degrades the communication between the first computing device and the second computing device; and

inhibiting, by the electronic processor, the transmission of the beacon to the second computing device when the electronic
processor determines that the third computing device is positioned such that the third computing device degrades the communication
between the first computing device and the second computing device;

determining a distance and angle between the first computing device and the second computing device based on the response
beacon from the second computing device;

generating, by the electronic device, a first encryption key, the first encryption key being based on the distance and angle
between the first computing device and the second computing device;

compressing, by the electronic processor, a first encryption key to generate a compressed encryption key;
applying, by the electronic processor, a universal hash function to the compressed encryption key to generate a second encryption
key, wherein the second encryption key is reduced in size from the first encryption key; and

transmitting, with the electronic processor, an encrypted message from the first computing device to the second computing
device using the second encryption key.

US Pat. No. 9,725,716

NON-IONIC, LOW OSMOLAR CONTRAST AGENTS FOR DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AND TREATMENT OF DISEASE

1. A composition comprising an antisense oligonucleotide complexed to a non-ionic, low-osmolar contrast agent.

US Pat. No. 9,616,226

DEVICES AND SYSTEMS FOR TREATING OBSTETRIC AND GYNECOLOGICAL DISORDERS

Ohio State Innovation Fou...

1. A therapy delivery system for treating an obstetric or gynecological disorder other than urinary incontinence in a subject,
the therapy delivery system comprising:
a housing configured for implantation in a reproductive system of the subject;
at least one electrode connected to the housing and configured to deliver an electrical signal to an autonomic nervous system
(ANS) nerve target; and

a controller programmed to direct delivery of the electrical signal to the at least one electrode to modulate activity at
the ANS nerve target site to treat the obstetric or gynecological disorder.

US Pat. No. 9,488,572

NON-CONTACT PROBE MEASUREMENT TEST BED FOR MILLIMETER WAVE AND TERAHERTZ CIRCUITS, INTEGRATED DEVICES/COMPONENTS, SYSTEMS FOR SPECTROSCOPY USING SUB-WAVELENGTH-SIZE-SAMPLES

OHIO STATE INNOVATION FOU...

1. An apparatus for performing terahertz (THz) or millimeter wave (mmW) characterization of an associated device-under-test
(DUT), the apparatus comprising:
a test fixture configured to hold the associated DUT, the test fixture including first and second off-axis planar antennas
designed to transmit and receive along different respective first and second off-axis directions, and a planar waveguide arranged
to guide THz or mmW radiation between the first and second off-axis planar antennas and further configured to couple THz or
mmW radiation guided between the first and second off-axis planar antennas with the associated DUT held by the test fixture,
wherein the test fixture includes no wired connection to a THz or mmW signal source;

a beam forming apparatus arranged to wirelessly transmit a probe THz or mmW beam along the first off-axis direction to the
first off-axis planar antenna of the test fixture; and

a THz or mmW receiver arranged to wirelessly receive a THz or mmW signal emitted along the second off-axis direction by the
second off-axis planar antenna responsive to transmission of the probe THz or mmW beam to the first off-axis planar antenna.

US Pat. No. 9,861,690

EHRLICHIA EWINGII PROTEINS, NUCLEIC ACIDS, AND METHODS OF THEIR USE

Ohio State Innovation Fou...

1. A method for detecting antibodies specific for both E. ewingii (EE) and/or E. chaffeensis, comprising: (a) contacting a test sample with one or more isolated EE polypeptides under conditions that allow polypeptide/antibody
complexes to form; and (b) assaying for the formation of a complex between antibodies in the test sample and the one or more
EE polypeptides; wherein the formation of said complex is an indication that antibodies specific for E. ewingii and/or E. chaffeensis are present in the test sample; wherein at least one of the one or more isolated EE polypeptides comprises an amino acid sequence
that comprises 6 or more consecutive amino acids of a mature OMP-1-15 protein encoded by nucleotide 15689-16450 of SEQ ID
NO: 1, and wherein an anti-E. ewingii and/or E. chaffeensis antibody has a specific binding affinity for the at least one of the one or more isolated EE polypeptides.

US Pat. No. 9,732,144

INFECTIOUS BURSAL DISEASE (IBDV) VACCINE COMPOSITIONS

Ohio State Innovation Fou...

1. A polyvalent VP2 trimer of infectious bursa disease virus (IBDV), wherein the polyvalent VP2 trimer comprises three VP2
monomers, and wherein at least one of the VP2 monomers is from a classic strain of IBDV, and wherein at least one of the VP2
monomers is from a variant strain of IBDV.
US Pat. No. 9,718,888

METHODS AND COMPOSITIONS RELATED TO SINGLE CHAIN ANTIBODY FRAGMENTS THAT BIND TO TUMOR-ASSOCIATED GLYCOPROTEIN 72 (TAG-72)

Ohio State Innovation Fou...

1. An antibody fragment which specifically binds tumor-associated glycoprotein 72 (TAG-72), wherein the antibody fragment
comprises SEQ ID NO: 1 or SEQ ID NO: 2.
US Pat. No. 9,526,772

EHRLICHIAL INVASIN FOR IMMUNIZATION, DIAGNOSIS, AND CELL DELIVERY

Ohio State Innovation Fou...

1. A method for delivering a therapeutic or diagnostic agent to a cell in a subject, comprising administering to the subject
a composition comprising the agent, wherein the agent, or a delivery vehicle comprising the agent, is conjugated to a delivery
polypeptide comprising an amino acid sequence having at least 70% identity to SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, or to
a nucleic acid encoding the polypeptide operably linked to a promoter.

US Pat. No. 9,524,730

MONAURAL SPEECH FILTER

OHIO STATE INNOVATION FOU...

1. A system separating speech from background noises, comprising:
a cochlear filter which receives monaural sound in an electronic format which includes speech and a plurality of background
noises and divides the received sound by frequency and time into a plurality of time-frequency units;

one or more processing units which classify each time-frequency unit as speech or non-speech and output each time-frequency
unit classified as speech, the processing unit for each frequency range including at least one of:

a deep neural network which extracts and classifies the features of the time-frequency unit and includes a pre-trained stack
of Restricted Boltzmann Machines, each Restricted Boltzmann Machine includes a visible layer and a hidden layer; or

a linear support vector machine which classifies the each time-frequency unit based on extracted features from the deep neural
network and includes visible features and hidden features, the visible features include a first visible layer of a first Restricted
Boltzmann Machine in the pre-trained stack of Restricted Boltzmann Machines, and the hidden features includes a hidden layer
of a last Restricted Boltzmann Machine in the stack, and

wherein the linear support vector machine and deep neural network include training with a plurality of training noises.

US Pat. No. 9,903,355

METHOD AND SYSTEM FOR MULTI-STAGE COMPRESSION OF A GAS USING A LIQUID

Ohio State Innovation Fou...

21. A system for compressing a gas using a liquid, comprising:
a buffer chamber;
a first compression stage first chamber in fluid communication with the buffer chamber, said first compression stage first
chamber having a first volume of liquid, wherein a pressurized gas is forced into the first compression stage first chamber
having the first volume of liquid;

a first compression stage pump; and
a first compression stage second chamber, wherein a first volume of gas is maintained in the first compression stage second
chamber and wherein the first volume of gas is at a first pressure and said first compression stage first chamber and said
first compression stage second chamber are fluidly connected through the first compression stage pump,

wherein at least a portion of the first volume of liquid in the first compression stage first chamber is simultaneously pumped
to the to the first compression stage second chamber, wherein the at least a portion of the first volume of liquid pumped
into the first compression stage second chamber compresses the first volume of gas in the first compression stage second chamber
to a second pressure greater than the first pressure.

US Pat. No. 9,716,312

MULTIPLE-INPUT MULTIPLE-OUTPUT ULTRA-WIDEBAND ANTENNAS

Ohio State Innovation Fou...

1. An ultra-wideband (“UWB”) multiple-input multiple-output (“MIMO”) antenna for use across a continuous, wide-range frequency
band, comprising:
a ground plane;
a wideband monopole antenna arranged over the ground plane; and
a ring antenna arranged over the ground plane and around the wideband monopole antenna, the ring antenna including a plurality
of pairs of dipole antennas, wherein respective dipole antennas of each of the pairs of dipole antennas are configured for
symmetrical, out-of-phase coupling with the wideband monopole antenna, wherein the wideband monopole antenna and the ring
antenna are configured to generate respective electric fields having orthogonal polarizations, wherein the ring antenna is
approximately square-shaped, wherein each of the respective dipole antennas comprises a plurality of conductive arms extending
in opposite directions from an excitation point, wherein each of the conductive arms comprises a plurality of conductive patches,
and wherein one or more coupling slits are arranged between the conductive patches of each of the conductive arms.

US Pat. No. 9,211,297

EXERCISE PERFORMANCE-INCREASING NUTRITIONAL SUPPLEMENT AND RELATED METHODS AND COMPOSITIONS

Ohio State Innovation Fou...

1. A nutritional supplement, comprising L-carnitine;
phosphatidylserine; ferrous glycinate, copper glycinate; and zinc glycinate.
US Pat. No. 9,845,469

ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF SPINAL MUSCULAR ATROPHY

Ohio State Innovation Fou...

1. An antisense oligonucleotide having a nucleotide sequence that is complementary to a non-continuous portion of a sequence
of intron 6, intron 7, or exon 7 of a survival motor neuron (SMN) 2 gene, the nucleotide sequence of the antisense oligonucleotide
being chosen from [SEQ ID NO 1], [SEQ ID NO 2], [SEQ ID NO 4], [SEQ ID NO 5], [SEQ ID NO 6], [SEQ ID NO 7], [SEQ ID NO 8],
[SEQ ID NO 9], [SEQ ID NO 10], [SEQ ID NO 11], [SEQ ID NO 12], [SEQ ID NO 13], and [SEQ ID NO 15];
wherein each nucleoside of the antisense oligonucleotide is linked to a morpholino ring.

US Pat. No. 9,990,472

SYSTEM AND METHOD FOR SEGMENTATION AND AUTOMATED MEASUREMENT OF CHRONIC WOUND IMAGES

Ohio State Innovation Fou...

1. A method for segmentation and automated measurement of chronic wound images comprising:obtaining a digital image, wherein at least a portion of the image comprises a wound;
transforming each pixel of the digital image to a modified Hue-Saturation-Value (HSV) color space, wherein transforming each pixel of the digital image to a modified Hue-Saturation-Value (HSV) color space comprises scaling Saturation (S) and Value (V) components of a HSV color space by:
where Smod and Vmod are modified Saturation and modified Value of the modified HSV color space, respectively, and a is a constant;creating a probability map by determining a probability of each of the transformed pixels in the modified HSV color space belonging to each of four colors of a four-dimensional color map;
segmenting each of the transformed pixels in the modified HSV color space to one or more groups based on each transformed pixel's color as determined by the probability map, wherein each of the one or more groups correspond to only one of the four colors of the four-dimensional color map;
automatically identifying each of the one or more groups as belonging to the wound as granulation, slough or eschar tissue based on the one of the four colors of the four-dimensional color map that corresponds to each of the one or more groups;
automatically determining at least one of a boundary, size, or an area of the wound based on the one or more groups identified as belonging to the wound as granulation, slough or eschar tissue; and
providing the determined at least one of the boundary, the size or the area of the wound, wherein the provided determined at least one of the boundary, the size or the area of the wound is used to monitor wound healing.

US Pat. No. 9,750,405

AUTOMATED DETECTION OF EYE ALIGNMENT

Ohio State Innovation Fou...

1. A method for automatically measuring a subject's phoria while the subject fixates on a visual target, comprising:
covering and uncovering at least one of the subject's eyes;
capturing a sequence of images of the at least one of the subject's eyes after uncovering the at least one of the subject's
eyes using an image capturing device, a first image of the sequence of images including a first reflection of light from the
at least one of the subject's eyes and a second image of the sequence of images including a second reflection of light from
the at least one of the subject's eyes, wherein the first image and the second image are captured at different times after
uncovering the at least one of the subject's eyes;

comparing a position of the first reflection of the light within the first image of the sequence of images to a position of
the second reflection of the light within the second image of the sequence of images to determine a magnitude and a direction
of any movement after the at least one of the subject's eyes is uncovered; and

determining a phoria measurement based on the determined magnitude and direction of the movement after the at least one of
the subject's eyes is uncovered.

US Pat. No. 9,896,091

OPTIMIZED PATH PLANNER FOR AN AUTONOMOUS VALET PARKING SYSTEM FOR A MOTOR VEHICLE

Ohio State Innovation Fou...

1. A method for autonomously parking or un-parking a motor vehicle, the method comprising:
locating the motor vehicle relative to a parking area;
selecting a destination location within the parking area;
generating a path from the location of the motor vehicle to the destination location, wherein the path includes a plurality
of linked nodes, each node having a cost associated therewith, wherein the cost of a child node is equal to an inherited cost
plus a base cost and a change cost, wherein the change cost is a function of characteristics of a parent node;

autonomously driving the motor vehicle along the path from the location of the motor vehicle to the destination location.

US Pat. No. 9,851,454

DETECTION DEVICES AND METHODS

OHIO STATE INNOVATION FOU...

1. A detection device comprising:
a first semiconductor device;
a second semiconductor device;
an electron separator layer between the first semiconductor device and the second semiconductor device; and
a conversion layer between the first semiconductor device and the second semiconductor device;
wherein the conversion layer comprises gadolinium;
wherein the conversion layer has a thickness of from about 20 ?m to about 40 ?m;
wherein the electron separator layer comprises a first surface and a second surface; and
wherein the first surface is in physical contact with the conversion layer.

US Pat. No. 9,852,896

METHOD AND APPARATUS FOR CONTAINED-ELECTROSPRAY FOR USE IN MASS SPECTROMETRY AND DROPLET REACTIONS

Ohio State Innovation Fou...

1. An apparatus comprising:
an electrospray emitter comprising (i) a sample capillary extending from a sample inlet to a sample outlet; and (ii) a voltage
source conductively coupled to the sample capillary and configured to apply a voltage to the sample capillary; and

an element comprising
(i) a conduit coaxially disposed around the electrospray emitter thereby forming a chamber extending between the conduit and
the sample capillary and terminating in a gas outlet;

(ii) a carrier gas inlet fluidly connected to the chamber; and
(iii) a working gas inlet fluidly connected to the chamber;
wherein the chamber is configured to provide a path for fluid flow from the carrier gas inlet and the working gas inlet to
the gas outlet.

US Pat. No. 9,777,265

NON-CONTACT METHOD FOR ACCELERATING WOUND HEALING USING AN ELECTROMAGNETIC COIL TO INDUCE AN ELECTRIC FIELD TRANSVERSE TO AN AXIS OF THE WOUND

OHIO STATE INNOVATION FOU...

1. A method for controlling cell migration comprising the steps of:
providing an electromagnetic coil having a first end and a second end;
connecting the electromagnetic coil to a function generator;
applying a time-varying voltage waveform to the electromagnetic coil;
inducing a time-varying electric field around the electromagnetic coil;
placing the electromagnetic coil adjacent to the location of a wound, the wound comprised of wound cells;
orientating the placement of the electromagnetic coil to control the direction of the induced electric field;
directing the induced electric field in a direction transverse to an axis of the wound;
wherein the time-varying voltage waveform has a sharp drop at the trailing edge of the waveform and wherein the induced electric
field is produced by a rapidly time-varying magnetic field;

and
controlling the migration of the wound cells using the induced electric field.

US Pat. No. 10,178,580

SYSTEM AND METHOD FOR EFFICIENT USE OF NETWORK BANDWIDTH BASED ON USER PROFILES AND OTHER DATA

OHIO STATE INNOVATION FOU...

1. A system for optimizing the use of network bandwidth by a mobile device comprising:a mobile application client residing on the mobile device and connected to a cloud server via a network comprising
a mobile application content logger module that logs an application identifier, a logging time, and a content parameter for each content request into a content log, and
a mobile application battery logger module that logs a battery usage of a battery of the mobile device, wherein the system analyzes user content consumption by a user of the mobile device to create a user profile, the system compiles a prefetching schedule of content anticipated to be requested by the user based on the user profile and the content log, the user profile including data reflecting a condition selected from the group consisting of network access of the mobile device, the battery usage of the mobile device, the user content consumption, the content anticipated to be requested by the user, previous content requested by the user, hit ratio dynamics, user connectivity patterns, data consumption rates, efficiency of data delivery and combinations thereof, the user profile is based on a content dynamic refresh rate, wherein the mobile application client provides the prefetching schedule to the mobile device, and wherein the mobile device prefetches content partially in accordance with the prefetching schedule to provide an optimized quality of service based at least in part upon a current network resource.

US Pat. No. 9,903,584

SYSTEMS FOR CONVERTING FUEL

Ohio State Innovation Fou...

1. A system for converting fuel comprising:
a first moving bed reactor comprising at least one tapered section and multiple injection gas ports in a tangential injection
configuration, the multiple injection gas ports being configured to tangentially inject a fuel into the first moving bed reactor,
wherein the first moving bed reactor is configured to reduce an oxygen carrying material with a fuel by defining a countercurrent
flowpath for the fuel relative to the oxygen carrying material, wherein the first moving bed reactor has multiple tapered
sections that are aligned in parallel, such that the first moving bed reactor has multiple outlet streams, and wherein the
multiple tapered sections emanate from a bottom section of the first moving bed reactor;

a second reactor communicating with the first moving bed reactor operable to receive an oxygen source, wherein the second
reactor is configured to regenerate the reduced oxygen carrying material by oxidation; and

a non-mechanical valve comprising a circuitous piping assembly disposed between the first moving bed reactor and the second
reactor, and at least one gas opening configured to receive a gas stream, the gas stream being operable to reduce gas leakage
between the first moving bed reactor and the second reactor.

US Pat. No. 9,867,537

AUTOMATED DETECTION OF EYE ALIGNMENT

Ohio State Innovation Fou...

1. A method for automatically measuring a subject's phoria while the subject fixates on a visual target, comprising:
capturing an image of at least one of the subject's eyes using an image capturing device, the image including a reflection
of light from any surface of the at least one of the subject's eyes;

analyzing the image to identify a position of the reflection of the light within the at least one of the subject's eyes;
determining a phoria measurement based on the position of the reflection of the light within the at least one of the subject's
eyes;

performing an autorefraction measurement, the autorefraction measurement measuring a power of one of the subject's eyes while
focusing on the visual target; and

calculating an accommodative convergence accommodation ratio based on a position of the reflection of the light within at
least one of the subject's eyes and the autorefraction measurement.

US Pat. No. 9,945,824

CORE-SHELL NANOFIBER-BASED SENSORS

Ohio State Innovation Fou...

1. A core shell nanofiber comprising (a) a core comprising a first polymer and an oxygen sensor dispersed therein; and (b) a shell comprising a second polymer disposed coaxially around the core,wherein the nanofiber has a diameter of about 1000 nm or less.

US Pat. No. 9,874,620

LOW FIELD MAGNETIC RESONANCE IMAGING (MRI) SCANNER FOR CARDIAC IMAGING

Ohio State Innovation Fou...

1. A method for reconstructing image data, comprising:
acquiring multichannel k-space data;
determining a noise power of the k-space data;
determining coil-sensitivity maps;
initializing values of relative weights that are respectively applied to subdictionaries used to model an image;
iteratively minimizing a weighted l1-norm of image representation in subdictionaries in accordance with the relative weights while constraining a residual norm
of a data-fidelity term based on the determined noise power;

updating, within each iteration, the relative weights of the subdictionaries based on a subdictionary-specific maximum likelihood
fitting of coefficient distributions with a Laplacian; and

outputting reconstructed images upon convergence of a cost function used to estimate the reconstructed images.

US Pat. No. 9,868,767

CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES

Ohio State Innovation Fou...

1. A compound of Formula I-A:

wherein
Xm and Xn independently comprise a sequence of 1-10 amino acids;

R0 is selected from hydrogen, substituted or unsubstituted C1-C6 alkyl, or linker to solid phase support; and

K has a structure represented by a formula:

US Pat. No. 9,983,288

FREE-BREATHING MYOCARDIAL T2* MAPPING USING SINGLE-HEARTBEAT, MULTI-SHOT, GRADIENT ECHO-ECHO PLANAR IMAGING (GRE-EPI) AND AUTOMATIC NON-RIGID MOTION CORRECTION

Ohio State Innovation Fou...

1. A method for performing free-breathing T2* image mapping, comprising:acquiring a series of images with varying levels of T2*-weighting, the acquiring of individual images being performed within a predetermined time period having a length that substantially negates effects of motion caused by respiration;
motion correcting the T2*-weighted images; and
calculating a T2* map,
wherein the predetermined time period is approximately 300 ms.
US Pat. No. 9,901,569

COMPOSITIONS AND METHODS FOR INHIBITING LEISHMANIA

OHIO STATE INNOVATION FOU...

1. A method of reducing the Leishman-Donovan units (LDU) of Leishmaniasis in a host, comprising: administering a daily dose
of at least about 0.1 mg/kg of an autophagy inducer (AI) to the host wherein the AI is AR-12 (2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide)
and is co-administered with a second compound, and the Leishman-Donovan units (LDU) of Leishmaniasis in the host of Leishmaniasis
are reduced.

US Pat. No. 10,253,266

SYNTHETIC FUELS AND CHEMICALS PRODUCTION WITH IN-SITU CO2 CAPTURE

OHIO STATE INNOVATION FOU...

1. A method for producing a liquid fuel from a solid carbonaceous fuel comprising:directly liquefying a first portion of the solid carbonaceous fuel with a hydrogen rich gas stream to form the liquid fuel; and
indirectly gasifying a second portion of the solid carbonaceous fuel to form separate streams of hydrogen and CO2 rich gases by:
reducing metal oxide containing particles in a first reaction zone with the second portion of the solid carbonaceous fuel thereby forming the CO2 rich gases and reduced metal oxide containing particles;
directly sending a first portion of the reduced metal oxide containing particles from the first reaction zone to a second reaction zone, and a second portion of the reduced metal oxide containing particles from the first reaction zone to a third reaction zone;
oxidizing the first portion of the reduced metal oxide containing particles in the second reaction zone with steam thereby generating the hydrogen rich gases and at least partially oxidized metal oxide containing particles;
sending the at least partially oxidized metal oxide containing particles from the second reaction zone to the third reaction zone;
oxidizing the at least partially oxidized metal oxide containing particles from the second reaction zone and the second portion of the reduced metal oxide containing particles from the first reaction zone in the third reaction zone with an oxygen containing gas, thereby generating oxidized metal oxide containing particles; and
returning the oxidized metal oxide containing particles from the third reaction zone to the first reaction zone; and
reacting hydrogen from the hydrogen rich gases with carbon dioxide from the CO2 rich gases in a CO2 hydrogenation reaction to form synthetic liquid fuel.

US Pat. No. 9,896,450

MODULATORS OF CLAVIBACTER MICHIGANENSIS AND METHODS OF MAKING AND USING THEREOF

Ohio State Innovation Fou...

1. A seed coated or primed with a compound having Formula I:

wherein
A is —C(O)—NR3— or —NR3—C(O)—;

n is 0, 1, or 2;
R1 is an aryl or heteroaryl, optionally substituted with one or more hydroxyl, halogen, alkyl, alkenyl, alkynyl, alkoxyl, alkenyloxyl,
amino, aminoalkyl, aminoalkenyl, cycloalkyl, cycloalkenyl, alkylcarboxylate, cycloalkylcarboxylate, alkylcarbonate, cycloalkylcarbonate,
amidoalkyl, amidocycloalkyl, aryl or heteroaryl;

R2 is a C1-4 alkylene, C1-4 alkoxylene, or C3-5 alkenylene, optionally substituted with hydroxyl, halogen, oxo, amino, or C1-6 alkyl;

R3 is H or C1-6 alkyl; and

R4 is an aryl or heteroaryl, optionally substituted with one or more hydroxyl, halogen, alkyl, alkenyl, alkynyl, alkoxyl, alkenyloxyl,
amino, aminoalkyl, aminoalkenyl, cycloalkyl, cycloalkenyl, alkylcarboxylate, cycloalkylcarboxylate, alkylcarbonate, cycloalkylcarbonate,
amidoalkyl, amidocycloalkyl, aryl or heteroaryl;

or an agriculturally suitable salt thereof.

US Pat. No. 10,022,693

SYSTEMS AND METHODS FOR PARTIAL OR COMPLETE OXIDATION OF FUELS

OHIO STATE INNOVATION FOU...

1. A method of producing syngas, the method comprising:providing a counter-current contact mode between a first metal oxide and a first fuel in a first reactor to reduce the first metal oxide to a second metal oxide, wherein the first reactor comprises a plurality of oxygen carrying particles and wherein the plurality of oxygen carrying particles comprises the first metal oxide;
oxidizing the second metal oxide to a third metal oxide in a second reactor, and reducing the third metal oxide to a fourth metal oxide with a second fuel to provide a partially or fully oxidized gaseous fuel comprising one or more of CO, CO2, H2, and H2O, wherein the second metal oxide is oxidized to the third metal oxide using an enhancing gas of CO2 and H2O, the partially or fully oxidized gaseous fuel, or a combination thereof, to generate syngas and wherein the second reactor is in communication with the first reactor; and
regenerating the first metal oxide by oxidizing the fourth metal oxide with an oxygen source in a third reactor, wherein the third reactor is in communication with the second reactor.

US Pat. No. 9,985,461

SYSTEMS CAPABLE OF SELF-HARVESTING ENERGY FROM WIRELESS DEVICES AND METHODS OF USING THE SAME

OHIO STATE INNOVATION FOU...

1. A system comprising:a first antenna configured to generate a first alternating-current (AC) power signal based on a first received radio-frequency (RF) signal associated with a first frequency band;
a second antenna configured to generate a second AC power signal based on a second received RF signal associated with a second frequency band, wherein the first and second received RF signals are generated by an associated wireless device, wherein the first frequency band is different from the second frequency band;
a signal converting circuit configured to generate a direct-current (DC) power signal having a given amount of power based on the first and the second AC power signals; and
a power management circuit configured to deliver electrical energy to a battery of the associated wireless device based on the given amount of power of the DC power signal.

US Pat. No. 9,927,385

ACTIVE CONTROL GUARDS AND RATIONOMETRIC CALIBRATION AND RECONSTRUCTION FOR USE WITH ELECTRICAL CAPACITANCE VOLUME TOMOGRAPHY

OHIO STATE INNOVATION FOU...

1. A system for generating a three-dimensional tomograph of a vessel interior or other object, the system comprising:a three-dimensional capacitance sensor device comprising a plurality of electrodes for placement around the vessel or the object, wherein the three-dimensional capacitance sensor device is adapted to provide electric field distribution and sensor sensitivity in three geometric dimensions;
data acquisition electronics in communication with the three-dimensional capacitance sensor device for receiving input data from the plurality of electrodes of the three-dimensional capacitance sensor device;
a plurality of active control segments placed around the plurality of the electrodes, wherein each of the plurality of active control segments are electrically isolated from the plurality of electrodes;
an isolation circuit connected to each of the plurality of active control segments comprising an independent path for currents that is electrically isolated from current on the plurality of electrodes;
a processing system in communication with the data acquisition electronics, the processing system programmed with instructions for executing on the processing system to reconstruct a three-dimensional volume-image from the input data collected by the data acquisition electronics;
wherein the system is configured to allow activation of each active control segment individually and wherein the system is configured to activate the active control segments with a specific activation pattern.

US Pat. No. 9,927,395

MINIATURIZED GAS SENSOR DEVICE AND METHOD

Ohio State Innovation Fou...

1. A microfabricated potentiometric gas sensor device comprising:a base substrate;
an electrolyte layer disposed on the base substrate; and
a plurality of potentiometric sensor units connected in series and coupled to the base substrate, each potentiometric sensor unit comprising:
an electrolyte layer disposed on the base substrate;
a two-part sensing electrode comprising a layer of tungsten oxide (WO3) disposed on a platinum (Pt) contact; and
a reference electrode comprising platinum (Pt);
wherein the ratio of the surface area of the tungsten oxide (WO3) of the sensing electrode disposed on the electrolyte to the surface area of the Pt of the reference electrode disposed on the electrolyte is at least 2 to 1.
US Pat. No. 9,974,771

COMPOSITIONS AND METHODS FOR REDUCING PRION LEVELS

OHIO STATE INNOVATION FOU...

1. A method of reducing the level of prions in prion-infected cells, tissues or organs, comprising exposing prion-infected cells, tissues or organs to AR-12 in an amount sufficient to reduce the level of prions in the prion-infected cells, tissues or organs by at least about 50% compared to prion-infected cells, tissues, organs that have not been exposed to AR-12.
US Pat. No. 10,131,952

MIRNA BIOMARKERS FOR MONITORING BONE MARROW RECONSTITUTION

Ohio State Innovation Fou...

1. A method for monitoring hematopoietic reconstitution or suppression in a subject, comprising quantifying the levels of circulating miR-150 in a cell-free blood sample from a subject recipient of a population of hematopoietic stem cells, wherein the levels of circulating miR-150 in the sample is a measure of hematopoietic reconstitution or suppression.

US Pat. No. 10,039,833

DRUG DELIVERY SYSTEM TO INCREASE BIOAVAILABILITY

OHIO STATE INNOVATION FOU...

1. A drug delivery system comprising at least about 2 to about 40 weight percent of a glidant and a compound of Formula I:
or metabolites or pharmaceutically acceptable salts thereof.
US Pat. No. 9,890,428

MIRNA BIOMARKERS FOR RADIATION BIODOSIMETRY

Ohio State Innovation Fou...

1. A method for measuring exposure of a human subject to ionizing radiation and administering a treatment method according
to results thereof, comprising
(a) assaying a cell-free blood sample from a human subject exposed to radiation to measure the levels of miR-150;
(b) assaying the sample to measure the levels of miR-23a;
(c) normalizing the miR-150 levels based specifically on the miR-23a levels;
(d) estimating the measure of ionizing radiation exposure from the normalized miR-150 levels;
(e) identifying a human subject exposed to a remediable level of radiation poisoning, and
(f) administering to the human subject exposed to a remediable dose of radiation poisoning an immune modulator or mitigator
according to level of radiation exposure.

US Pat. No. 10,098,967

SELF-ASSEMBLY OF THERAPEUTIC AGENT-PEPTIDE NANOSTRUCTURES

Ohio State Innovation Fou...

1. A nanotube comprising a wall, wherein the wall comprises a plurality of conjugates of Formula II
where n is from 1 to 4,
each R1 and R2 are, independent of one another, H, OH, lower alkyl, lower alkenyl, lower alkynyl, lower alkanoyl, lower heteroalkyl, lower heterocycloalkyl, lower haloalkyl, lower haloalkenyl, lower haloalkynyl, lower perhaloalkyl, lower perhaloalkoxy, lower cycloalkyl, phenyl, aryl, aryloxy, lower alkoxy, lower haloalkoxy, oxo, lower acyloxy, carbonyl, carboxyl, lower alkylcarbonyl, lower carboxyester, lower carboxamido, cyano, hydrogen or deuterium, halogen, hydroxy, amino, lower alkylamino, arylamino, amido, nitro, thiol, lower alkylthio, lower haloalkylthio, lower perhaloalkylthio, arylthio, sulfonate, sulfonic acid, trisubstituted silyl, N3, SH, SCH3, C(O)CH3, CO2CH3, or CO2H, or together two R1 or R1 and R2 can form a fused cycloalkyl or cycloheteroalkyl;
L is C(O)—(CH2)m—C(O), where m is from 1 to 6;
AA is a protected or unprotected lysyl-lysyl or lysyl-phenylalanyl-lysyl-lysyl (SEQ ID NO:6); wherein L is bonded at a side chain of one of the lysyl residues of AA.

US Pat. No. 9,941,117

TUNNELING FIELD EFFECT TRANSISTORS AND TRANSISTOR CIRCUITRY EMPLOYING SAME

OHIO STATE INNOVATION FOU...

11. A method for fabricating a tunneling field-effect transistor (TFET), the method comprising:epitaxially growing a silicon-germanium TFET layer structure by low-temperature molecular beam epitaxy (LT-MBE) wherein the silicon-germanium TFET layer structure includes a degenerately doped layer and a channel layer of silicon or silicon-germanium spaced apart from the degenerately doped layer by a tunneling spacer layer of silicon or silicon-germanium;
processing the silicon-germanium TFET layer structure to form a TFET device; and
annealing the silicon-germanium TFET layer structure at a temperature of at least 600° C.;
wherein the processing to form a TFET device is performed before or after the annealing.

US Pat. No. 9,927,394

MINIATURIZED GAS SENSOR DEVICE AND METHOD

Ohio State Innovation Fou...

1. A method of sensing gas, the method comprising:receiving an original sample; and
generating a potential difference in a microfabricated potentiometric sensor device in response to presence of gas in the sample, wherein the microfabricated potentiometric sensor device comprises:
a base substrate;
an electrolyte layer disposed on the base substrate;
a plurality of potentiometric sensor units connected in series and coupled to the base substrate, each potentiometric sensor unit comprising:
an electrolyte layer disposed on the base substrate;
a two-part sensing electrode comprising a layer of tungsten oxide (WO3) disposed on a platinum (Pt) contact;
a reference electrode comprising platinum (Pt);
wherein the ratio of the surface area of the tungsten oxide (WO3) of the sensing electrode disposed on the electrolyte to the surface area of the Pt of the reference electrode disposed on the electrolyte is at least 2 to 1.

US Pat. No. 9,916,919

SUPERCONDUCTING WIRES AND METHODS OF MAKING THEREOF

Ohio State Innovation Fou...

1. A superconducting wire comprising:
a matrix comprising a Cu-based metal; and
at least one continuous subelement embedded in the matrix;
wherein each subelement comprises:
a non-superconducting core;
a superconducting layer coaxially disposed around the non-superconducting core; and
a barrier layer coaxially disposed around the superconducting layer;
wherein the superconducting layer comprises a plurality of Nb3Sn grains stabilized by metal oxide particulates disposed therein,

wherein the Nb3Sn grains have an average grain size of from 5 nm to 90 nm; and

wherein the superconducting layer has a flux pinning force vs. field (Fp-B) curve that peaks at from 0.2 to 0.5 times the irreversibility field (Birr).

US Pat. No. 10,028,933

COMPOSITIONS AND METHODS FOR INHIBITING THE GROWTH OF MULTI-DRUG RESISTANT MICROBES

OHIO STATE INNOVATION FOU...

1. A method of reducing the load of Burkholderia cenocepacia in a host having cystic fibrosis, comprising:administering

and an antibiotic to the host wherein the load of the microbes is reduced by about 1000 fold.

US Pat. No. 9,911,062

BACKGROUND PHASE CORRECTION FOR QUANTITATIVE CARDIOVASCULAR MRI

Ohio State Innovation Fou...

1. A method of correcting eddy currents-induced background phase (EC-BP) in magnetic resonance imaging data, comprising:
acquiring phase-contrast data from a slice of interest (SOI) using a magnetic resonance imaging (MRI) scanner, with a user-specified
table position and SOI position and orientation; the SOI position and orientation, with respect to the magnet coordinate system,
being controlled by varying a center frequency of an applied radio-frequency (RF) excitation pulse in combination with a variation
of a slice select gradient amplitude and direction;

acquiring phase-contrast data from at least one additional slice, the at least one additional slice having the same position
and orientation, with respect to the magnet coordinate system, as the SOI and being acquired using the slice select gradient
amplitude and direction, the at least one additional slice imaging a physically different location of the subject, achieved
by either changing the table position with respect to the position used for the SOI acquisition or by physically moving the
subject within the scanner;

performing image reconstruction from k-space to image domain for the SOI and the at least one additional slice;
subtracting a phase of a reconstructed additional slice from a phase of a reconstructed SOI to extract phase difference maps
for the SOI and the at least one additional slice;

determining a correction map by:
processing the phase difference maps from both the SOI and the at least one additional slice; and
estimating EC-BP in accordance with a first relationship:

wherein x?k×1 represents the k coefficients of a 2D polynomial, wherein B and z are obtained by vertical concatenation of N temporally-averaged
slices, such that B[A1T|A2T| . . . |ANT]T and z[y1T|y2T| . . . |yNT]T, and ?Bx?z??2(Bx?z)???1(Bx?z), wherein each column of matrix A?M×k defines the spatial distribution of one of the polynomial terms, wherein vector y?M×1 is the measured temporally-averaged phase map, wherein ??NM×NM is a covariance matrix constructed by computing inner products of mean-subtracted temporal profiles across all pixel pairs
in z; and

correcting the BP of the SOI using the correction map.

US Pat. No. 10,137,301

MULTI-CARRIER PROCESSING IN AUDITORY PROSTHETIC DEVICES

Ohio State Innovation Fou...

1. A method for multi-carrier processing in an auditory prosthetic device, comprising:receiving an audio signal comprising multiple signals, each signal produced by an independent source;
identifying at least a first signal and a second signal in the received audio signal;
dividing the first signal into one or more frequency bands;
dividing the second signal into the one or more frequency bands, wherein the one or more frequency bands include a matching frequency band that is the same for both the first and second signals;
generating a first carrier signal and a second carrier signal for the matching frequency band;
dynamically adjusting an amplitude of the first carrier signal based on the first signal in the matching frequency band or a signal envelope associated with the first signal in the matching frequency band;
dynamically adjusting an amplitude of the second carrier signal based on the second signal in the matching frequency band or a signal envelope associated with the second signal in the matching frequency band;
adding the amplitude-adjusted first and second carrier signals associated with the matching frequency band; and
delivering the summed amplitude-adjusted first and second carrier signals associated with the matching frequency band to at least one electrode associated with an auditory prosthetic device.

US Pat. No. 10,074,814

GERMANANE ANALOGS AND OPTOELECTRONIC DEVICES USING THE SAME

OHIO STATE INNOVATION FOU...

1. A two-dimensional layer comprising M-R, wherein M is selected from the group consisting of Ge, and Sn; wherein R is C1-18 alkyl; and wherein the M-R is crystalline.
US Pat. No. 10,022,342

METHODS AND COMPOSITIONS FOR TREATING MULTIPLE MYELOMA

OHIO STATE INNOVATION FOU...

1. A method of sensitizing multiple myeloma cells to treatment with lenalidomide comprising administering AR-42 and lenalidomide to a patient in need treatment in an amount sufficient to achieve a blood or tissue concentration of at least about 0.5 to about 1 ?M of AR-42 and at least about 391 to about 568 ng/ml of lenalidomide.

US Pat. No. 9,939,509

VARIABLE DENSITY INCOHERENT SPATIOTEMPORAL ACQUISITION (VISTA) FOR HIGHLY ACCELERATED MAGNETIC RESONANCE IMAGING

Ohio State Innovation Fou...

1. A method of Variable density Incoherent Spatiotemporal Acquisition (VISTA) for generating magnetic resonance imaging (MRI) sampling location of N data samples on an n-dimensional (nD) grid, comprising;initializing a location of N k-space samples on the nD grid;
iteratively minimizing a cost function U to update the location of samples;
enforcing application specific constraints on the distribution of samples in each iteration;
generating a sampling pattern at each iteration; and
storing each sampling pattern as a lookup table, whereby MR images are reconstructed from the data collected using the lookup table.
US Pat. No. 9,873,813

BIOPROCESSING OF HARVESTED PLANT MATERIALS FOR EXTRACTION OF BIOPOLYMERS AND RELATED MATERIALS AND METHODS

OHIO STATE INNOVATION FOU...

1. A method of separating leaves from branches of harvested latex-containing plant material, wherein the harvested plant material
includes leaves, and branches comprised of latex-containing bark and woody cores,
the method comprising:
a) contacting the harvested plant material with a cryogenic liquid for an amount of time sufficient to embrittle a plurality
of leaves and a plurality of latex-containing bark;

b) applying a force to the harvested plant material of step a) sufficient to fracture the plurality of embrittled leaves and
the plurality of latex-containing embrittled bark, to form fractured leaf particles, and fractured bark particles; and

c) separating the embrittled fractured leaf particles and the embrittled fractured bark particles of step b) from the woody
cores.

US Pat. No. 10,677,932

SYSTEMS, METHODS, AND DEVICES FOR GEO-LOCALIZATION

Ohio State Innovation Fou...

1. A system, comprising:memory storing machine readable instructions; and
one or more processors to access the memory and execute the machine readable instructions to:
receive relative position signals generated for a device;
generate relative trajectories comprising directional information based on the relative position signals;
evaluate the directional information to identify a given discrete bin from a plurality of discrete bins for each relative trajectory;
transform each relative trajectory to a trajectory descriptor based on the given discrete bin;
connect each of the trajectory descriptors to define a progressive topology, wherein the progressive topology is a representation of a movement of the device;
compare the progressive topology to map data characterizing a region of interest, wherein the device is located within the region of interest; and
determine a geolocation for the device based on the comparison.

US Pat. No. 10,018,697

METHOD FOR ESTIMATING A GRAPPA RECONSTRUCTION KERNEL

OHIO STATE INNOVATION FOU...

1. A method of determining a k-space convolution kernel in GRAPPA reconstruction of magnetic resonance imaging, comprising:acquiring a multiple frame dynamic Magnetic Resonance (MR) image series comprising 2-D images or 3-D images at a same slice location (2-D) or slab location (3-D);
using multiple k-space data acquisition patterns, wherein each k-space data acquisition pattern acquires a subset of k-space lines;
averaging each acquired k-space data acquisition pattern to generate a block of fully sampled k-space;
providing at least two sets of auto-calibration signal (ACS) lines from the block of fully-sampled k-space; and
estimating the k-space convolution kernel from the at least two sets ACS lines, whereby Generalized Auto-calibrating Partially Parallel Acquisitions (GRAPPA) or temporal GRAPPA (TGRAPPA) reconstruction of images is performed using the k-space convolution kernel.

US Pat. No. 9,885,031

GALVANOTAXIS ASSAY FOR QUANTITATIVE ASSESSMENT OF THE METASTATIC POTENTIAL OF CANCER CELLS

OHIO STATE INNOVATION FOU...

1. A method for controlling cell migration comprising the steps of:
providing an electromagnetic coil having a first end and a second end;
connecting the electromagnetic coil to a function generator;
applying a time-varying voltage waveform to the electromagnetic coil;
inducing a time-varying electric field around the electromagnetic coil;
placing the electromagnetic coil adjacent to, and without contacting, the location of cells;
applying the induced electric field in a direction of cell migration; and
hindering the migration of the cells using the induced electric field.
US Pat. No. 10,357,543

METHODS AND COMPOSITIONS FOR TREATING DISORDERS AND DISEASES USING SURVIVAL MOTOR NEURON (SMN) PROTEIN

Ohio State Innovation Fou...

1. A method of reducing sarcopenia in an individual, the method comprising:a. identifying an individual with sarcopenia, an individual with symptoms of sarcopenia, or an individual at risk for developing sarcopenia, wherein the subject is 35 years old or older; and
b. administering to the individual a Survival Motor Neuron (SMN)—increasing substance, thereby reducing sarcopenia, sarcopenia symptoms, or the risk of sarcopenia in the individual.

US Pat. No. 10,191,302

CONTACT LENS COMPRISING LENTICULAR-LIKE CURVE

Ohio State Innovation Fou...

1. A contact lens comprising a superior lenticular aspect located in a central, upper portion of the lens, wherein the superior lenticular aspect of the lens is shaped to interact with an upper tarsal plate of an upper eyelid of a wearer such that the contact lens translates upward in a downgaze of the wearer to place a viewing zone of the contact lens over a pupil or cornea of the wearer and the superior lenticular aspect provides rotational stabilization to the contact lens.

US Pat. No. 10,016,656

AUTOMATICALLY ADJUSTABLE TREADMILL CONTROL SYSTEM

Ohio State Innovation Fou...

1. An automatic speed-adjusting treadmill system comprising:a position sensor configured to output a signal indicative of a location of a user on a treadmill belt;
a processor; and
a memory storing instructions that, when executed by the processor, cause the treadmill system to periodically determine the location of the user relative to a middle zone on the treadmill belt based on the output of the position sensor,
determine a speed adjustment command based on an average of a defined number of the periodically determined locations of the user, wherein a magnitude of the speed adjustment command is greater for identified locations further from the middle zone, define an updated target speed for the treadmill belt based at least in part on the speed adjustment command, and
adjust a speed of the treadmill belt based on the updated target speed;
wherein the instructions, when executed by the processor, cause the treadmill system to adjust the speed of the treadmill motor by:
queuing a plurality of speed adjustment commands for processing,
monitoring a magnitude and a direction of queued speed adjustment commands,
and skipping to a subsequent speed adjustment command if the magnitude or direction of the subsequent speed adjustment command is different than the magnitude or direction of an earlier queued speed adjustment command.

US Pat. No. 10,186,724

CARBON DIOXIDE SEPARATOR, FUEL CELL SYSTEM INCLUDING SAME, AND METHOD OF OPERATING THE FUEL CELL SYSTEM

BLOOM ENERGY CORPORATION,...

1. A carbon dioxide separator for a fuel cell system, the carbon dioxide separator comprising:a sweep channel configured to receive a sweep gas;
a feed channel configured to receive a fuel exhaust stream of the fuel cell system;
a carbon dioxide separation membrane disposed between the sweep channel and the feed channel, the carbon dioxide separation membrane having a higher permeability to carbon dioxide and water than to hydrogen gas, carbon monoxide, and nitrogen gas; and
a first blocking layer disposed on a first side of the carbon dioxide separation membrane and comprising a first oxygen blocking layer disposed between the carbon dioxide separation membrane and the sweep channel, the oxygen blocking layer having a higher permeability to water and carbon dioxide than to oxygen gas and nitrogen gas.

US Pat. No. 10,101,466

SYSTEMS, METHODS, AND DEVICES FOR GEO-LOCALIZATION

OHIO STATE INNOVATION FOU...

1. A system for geo-localization of a device comprising:one or more relative position sensors to generate relative position signals for the device; and
memory storing machine readable instructions; and
one or more processors to access the memory and execute the machine readable instructions to:
receive the relative position signals;
transform the relative position signals into relative trajectories, wherein each of the relative trajectories comprises directional information indicative of a change in orientation of the device;
identify a discrete bin, wherein each discrete bin comprises a range of angles, from a plurality of discrete bins based on the directional information for each relative trajectory at each instance of time;
transform each relative trajectory to a trajectory descriptor based on the identified discrete bin, wherein each trajectory descriptor comprises the range of angles of a respective discrete bin;
connect each of trajectory descriptors to define a progressive topology, wherein the progressive topology is a representation of a movement of the device;
compare the progressive topology to map data characterizing a region of interest, wherein the device is located within the region of interest; and
determine a geolocation for the device based on the comparison.
US Pat. No. 10,066,027

PROTEIN PRODUCTION SYSTEMS AND METHODS THEREOF

Ohio State Innovation Fou...

1. A protein purification system, wherein the system comprises a split intein comprising two separate peptides: an N-terminal intein segment and a C-terminal intein segment, wherein the N-terminal intein segment comprises one or more amino acids at its C-terminus which allows for covalent immobilization of the N-terminal intein segment to a solid support, and wherein cleaving of the C-terminal intein segment is more sensitive to extrinsic conditions compared to a native intein, wherein a protein of interest (POI) is attached to the C-terminal intein segment at its C-terminus.

US Pat. No. 10,086,062

INFECTIOUS PANCREATIC NECROSIS VIRUS (IPNV) VACCINE COMPOSITIONS

Ohio State Innovation Fou...

1. A polyvalent VP2 trimer of infectious pancreatic necrosis virus (IPNV), wherein the polyvalent VP2 trimer comprises three VP2 monomers, and wherein at least one of the VP2 monomers is from a different strain of IPNV than the other monomers, and wherein the VP2 monomers are each independently from an IPNV strain selected from the group consisting of IPNV2, IPNV10, Te, C1, Ab, He, C2, C3, SP, YTAV, WB, and Jasper.
US Pat. No. 10,214,574

ENGINEERED CALMODULIN FOR TREATMENT OF RYANOPATHIES

Ohio State Innovation Fou...

1. An isolated polypeptide comprising the amino acid sequence SEQ ID NO:1 having at least one mutation selected from the group consisting of F13Q, T27D, T29D, M37Q, L40Q, N61D, M72Q, and M73Q.

US Pat. No. 10,144,640

METHODS FOR FUEL CONVERSION

OHIO STATE INNOVATION FOU...

1. A method for converting gaseous fuel into syngas, the method comprising:feeding the gaseous fuel and composite metal oxides into a reduction reactor having a top and a bottom, wherein the gaseous fuel and the composite metal oxides are fed into the top of the reduction reactor, whereupon the composite metal oxides form a packed bed and the composite metal oxides and the gaseous fuel flow downward through the reactor in a co-current flow pattern relative to one another;
reducing the composite metal oxides with the gaseous fuel in the reduction reactor to form syngas and reduced composite metal oxides wherein the syngas comprises hydrogen and carbon monoxide;
removing the syngas and the reduced composite metal oxides from the bottom of the reduction reactor;
transporting the reduced composite metal oxides to an oxidation reactor;
regenerating the composite metal oxides by oxidizing the reduced composite metal oxides with an oxidizing reactant in the oxidation reactor; and
recycling the regenerated composite metal oxides to the reduction reactor for subsequent reduction reactions to produce syngas in the reduction reactor;
wherein the composite metal oxides comprise iron, titanium and oxygen and the reduced metal oxides comprise FeO.TiO2, or wherein the composite metal oxides comprise iron aluminum and oxygen and the reduced metal oxides comprise FeO.Al2O3.
US Pat. No. 10,030,045

PRIMERS AND METHODS FOR NUCLEIC ACID AMPLIFICATION

Ohio State Innovation Fou...

1. A primer for amplification of a target nucleic acid, the primer comprising a first sequence segment and a second sequence segment;wherein the first sequence segment comprises a G-rich sequence corresponding to the formula G3-3+N1-7G3-3+N1-7 G3-3+N1-7G0-3, and wherein the G content of the G-rich sequence is equal to or greater than 70%;
wherein at least a portion of the first sequence segment has a sequence comprising (GGGT)4 [SEQ ID NO: 1]; and
wherein the second sequence segment is sufficiently complementary to the target nucleic acid to hybridize therewith, and wherein the first sequence segment does not hybridize to the second sequence segment or to a sequence of the target nucleic acid, and wherein the G-rich sequence of the first sequence segment conforms into a quadruplex conformation during an extension step of an amplification process.
US Pat. No. 10,251,861

METHODS FOR TREATING BURN AND SCAR INJURY USING TOCOTRIENOL COMPOSITIONS

Ohio State Innovation Fou...

andb) improving skin scar or burn outcome in the subject.

US Pat. No. 10,231,625

INTERNALLY-ADMINISTERED RADIATION THERAPY USING ENDOSCOPIC IMAGE GUIDANCE

OHIO STATE INNOVATION FOU...

1. A method of treating intracavity tissue, the method comprising:coupling a distal end of an imaging probe catheter to a proximal end of the catheter tube, the imaging probe catheter partially containing the imaging probe;
positioning a distal end of a catheter tube at a target site inside an anatomical cavity;
operating an imaging probe positioned at the distal end of the catheter tube to capture image data of the target site;
generating three-dimensional images of the target site based on the captured image data;
developing a radiation treatment plan based on the three-dimensional images;
decoupling the distal end of the imaging probe catheter from the proximal end of the catheter tube before retracting the imaging probe from the catheter tube;
retracting the imaging probe from the catheter tube after capturing the image data of the target site while the distal end of the catheter tube remains positioned at the target site;
inserting the radiation source probe through the catheter tube to position the radiation source probe at the distal end of the catheter tube after retracting the imaging probe and before delivering a dosage of radiation;
coupling a radiation controller to the proximal end of the catheter tube after inserting the radiation probe into the catheter tube; and
operating a radiation source probe to deliver the dosage of radiation according to the radiation treatment plan, wherein the radiation source probe is operated while positioned at the distal end of the catheter tube at the target site and, wherein the catheter tube is not retracted after capturing the image data and before delivering the dosage of radiation,
wherein the proximal end of the catheter tube includes a first threaded coupling and a second threaded coupling, wherein the second threaded coupling is positioned coaxial to the first threaded coupling at a linear distance from the first coupling, and wherein a diameter of the first threaded coupling is different from a diameter of the second threaded coupling,
wherein coupling a distal end of the imaging probe catheter to a proximal end of the catheter tube includes coupling the distal end of the imaging probe catheter to the first threaded coupling of the catheter tube, and
wherein coupling the radiation controller to the proximal end of the catheter tube includes coupling the radiation controller to the second threaded coupling of the catheter tube.

US Pat. No. 10,010,847

CIRCULATING FLUIDIZED BED WITH MOVING BED DOWNCOMERS AND GAS SEALING BETWEEN REACTORS

Ohio State Innovation Fou...

1. A system for carrying out one or more chemical reactions comprising:a first chemical reactor having an inlet and an outlet for particulate solids, said particulate solids forming a bed in said first reactor, said outlet including a transition zone which narrows the internal diameter of said first reactor, said first reactor including an inlet for a solid or gaseous reactant and an outlet for a process gas;
a second chemical reactor having an inlet and an outlet for particulate solids, said particulate solids forming a bed in said second reactor, said second reactor including an inlet for a solid or gaseous reactant and an outlet for a process gas;
a first gas stripping zone forming a non-mechanical seal between said first and second reactors comprising a conduit connecting said first reactor with said second reactor, said conduit including a first end communicating with the solids outlet of said first chemical reactor and a second end communicating with the solids inlet of said second reactor, said first end of said conduit including an inlet for a stripping gas located between said first and second ends, said first gas stripping zone adapted to prevent process gas from said first reactor from entering said second reactor while permitting said particulate solids to pass from said first reactor into said second reactor;
a third chemical reactor communicating with said second chemical reactor, said third reactor having an inlet and an outlet for particulate solids, said particulate solids forming a bed in said third reactor;
a riser section communicating with the particulate solids outlet of said third reactor, said riser section adapted to recirculate entrained solids to said first reactor, said third reactor further including a source of gas; and
a second gas stripping zone forming a non-mechanical seal between said second and third reactors comprising a conduit connecting said second reactor with said third reactor, said conduit including a first end communicating with the solids outlet of said second chemical reactor and a second end communicating with the solids inlet of said third reactor, said first end of said conduit including an inlet for a stripping gas located between said first and second ends said second gas stripping zone adapted to prevent process gas from said second reactor from entering said third reactor while permitting said particulate solids to pass from said second reactor into said third reactor.

US Pat. No. 10,439,851

FREQUENCY-INDEPENDENT RECEIVER AND BEAMFORMING TECHNIQUE

Ohio State Innovation Fou...

1. An antenna array comprising:a plurality of antenna elements arranged in a matrix, the matrix having a number of columns and a number of rows, wherein each antenna element of the plurality of antenna elements exists at a position within the matrix at an intersection of a column and a row and wherein each antenna element of the plurality of antenna elements comprises a mixer configured to produce a phased superposition mix of a first signal and a second signal, wherein each antenna element comprises:
a respective antenna;
an output mixer coupled to the respective antenna and configured to produce a mix between a signal incident at the respective antenna and the phased superposition mix of the first signal and the second signal; and
an input mixer coupled to the respective antenna and configured to produce a mix between a third signal and the phased superposition mix of the first signal and the second signal;
a first set of phase shifters, each phase shifter of the first set of phase shifters being configured to apply a respective phase shift to an input signal; and
a second set of phase shifters, each phase shifter of the second set of phase shifters being configured to apply a respective phase shift to an input signal,
wherein the first set of phase shifters are arranged such that the first signal is applied with a same phase shift to each mixer of each antenna element in a respective column of the matrix, and
wherein the second set of phase shifters are arranged such that the second signal is applied with a same phase shift to each mixer of each antenna element in a respective row of the matrix.

US Pat. No. 10,187,327

PREDICTIVE NETWORK SYSTEM AND METHOD

OHIO STATE INNOVATION FOU...

1. A computerized method performed by a network server comprising:collecting from a mobile device connected to a network a plurality of network content requests;
comparing the plurality of requests against a statistical model to predict future network content requests from the mobile device, the statistical model based at least in part on network content requests from a plurality of mobile devices;
generating, from the comparison of requests against the statistical model, a list of anticipated network content requests from the mobile device, the list of anticipated network content requests comprising a first data source and a second data source; and
serving, to the mobile device, network content responsive to one or more of the anticipated network content requests from a source selected from a group consisting of the first data source, the second data source, and a combination thereof, wherein the serving occurs based on, in part, a comparison between a network supply and a network demand to ensure an optimal utilization of available network bandwidth, and wherein the network content is configured to be stored in a local memory at the mobile device, thereby being available for display on the mobile device upon a user's request.
US Pat. No. 9,938,576

MATERIALS AND METHODS FOR DETERMINING METABOLIZER STATUS IN HUMANS

Ohio State Innovation Fou...

1. A method of treating an individual with an appropriate dosage regimen, the method comprising:a) selecting an individual where CYP3A4 genotype at rs35599367 is CC and CYP3A5 genotype is wildtype CYP3A5*1;
b) determining the metabolizer status of the individual selected in step a), wherein when the CYP3A4 genotype at rs35599367 is CC and the CYP3A5 genotype is wildtype CYP3A5*1, the individual is considered an extensive metabolizer;
c) determining a standard dosage recommendation for drugs metabolized by CYP3A5 to active or inactive forms, wherein the standard dosage is not based on the results of step b); and
d) administering to the individual classified in step b) as an extensive metabolizer a higher dosage than the standard recommended dosage for drugs metabolized to inactive metabolites by CYP3A5 (and not by CYP3A4) as determined in step c), and a lower dosage than the standard recommended dosage for drugs metabolized to active metabolites by CYP3A5 (and not by CYP3A4).

US Pat. No. 10,247,802

SIGNAL INHOMOGENEITY CORRECTION AND PERFORMANCE EVALUATION APPARATUS

Ohio State Innovation Fou...

1. A method of correcting for inhomogeneous signal intensity in an MRI image, the method comprising:acquiring a set of signal intensity images;
estimating a receiver sensitivity map;
estimating a transmit function based on a transmit field and Bloch's equation of the signal intensity images;
calculating a transmit function with flip angle ?3 according to Bloch's equation;
estimating a relative correction image according to the transmit function and the receiver sensitivity map;
registering the relative correction image with the set of signal intensity images to produce a relative correction image;
normalizing the relative correction matrix to obtain a correction image; and
correcting inhomogeneity in the signal intensity images comprising calculating a ratio of the signal intensity images and the correction image.

US Pat. No. 10,167,311

BORONIC ACID ESTERS AND PHARMACEUTICAL FORMULATIONS THEREOF

Ohio State Innovation Fou...

1. A compound defined by Formula IA
wherein
Z, together with O1 and O2, represent a moiety derived from a polyol, wherein the polyol comprises a sugar;
L is absent, or is a linking group; and
A comprises a lipid moiety chosen from a fatty acid, a glycerolipid, a phospholipid, a sphingolipid, a sterol, or a prenol.

US Pat. No. 10,100,101

COMPOSITIONS AND METHODS RELATED TO VIRAL VACCINES

Ohio State Innovation Fou...

1. A polyvalent VP2 trimer of infectious pancreatic necrosis virus (IPNV), wherein the polyvalent VP2 trimer comprises three VP2 monomers, and wherein at least one of the VP2 monomers is from a different strain of IPNV than the other monomers.
US Pat. No. 10,093,702

METAPNEUMOVIRUS IMMUNOGENS AND RELATED MATERIALS AND METHODS

Ohio State Innovation Fou...

1. A composition comprising a live, attenuated human metapneumovirus (hMPV) comprising a mutated integrin-binding motif (RGD motif) in a fusion (F) protein of the live, attenuated hMPV, wherein the mutated RGD motif consists of a mutation or combination of mutations selected from: R329K; D331A; R329K and G330A; R329K and D331A; R329K and D331E; R329K and D331R; G330A and D331A; R329K, G330A, and D331A; R329K, G330A, and D331E; and R329K, G330A, and D331R.

US Pat. No. 10,302,864

METHOD OF FORMING A DETERMINISTIC THIN FILM FROM A CRYSTAL SUBSTRATE BY ETCHING A BILAYER BONDING INTERFACE TO CREATE A CHANNEL

Ohio State Innovation Fou...

1. A method of forming a deterministic thin film from a crystal substrate, comprising:implanting ions into a surface of the crystal substrate to form a thin film crystal layer;
bonding the crystal substrate and a handle substrate to form a bilayer bonding interface between the crystal substrate and the handle substrate, wherein the bilayer bonding interface comprises at least two different materials;
exfoliating the thin film crystal layer from the crystal substrate;
patterning the thin film crystal layer to define a deterministic thin film;
etching one or more trenches in the thin film crystal layer;
etching the at least two different materials of the bilayer bonding interface via the one or more trenches, wherein etching the bilayer bonding interface creates a channel between the at least two different materials; and
releasing the deterministic thin film from the handle substrate.

US Pat. No. 10,213,747

MEMBRANES FOR GAS SEPARATION

Ohio State Innovation Fou...

1. A membrane comprising:a support layer; and
a selective polymer layer disposed on the support layer, the selective polymer layer comprising an oxidatively stable carrier dispersed within a hydrophilic polymer matrix,
wherein the oxidatively stable carrier is selected from the group consisting of a quaternary ammonium hydroxide-containing polymer, a quaternary ammonium fluoride-containing polymer, and combinations thereof.

US Pat. No. 10,195,072

DEVICES AND METHODS FOR COOLING PATIENTS

OHIO STATE INNOVATION FOU...

1. A portable pneumatic cooling device comprising:a handheld housing including a first end and a second end;
a handle extending from an outer surface of the housing;
an inlet positioned at substantially the first end of the housing, the inlet configured to receive a supply of medical grade air into the housing,
an outlet positioned at substantially the second end of the housing, the outlet configured to deliver the supply of medical grade air outside of the housing, and
a pathway extending through the housing between the inlet and the outlet, the pathway having a first portion and a second portion, the first portion having a first diameter and the second portion having a second diameter less than the first diameter, wherein the pathway is configured to passively move the supply of medical grade air between the inlet and the outlet.
US Pat. No. 10,179,166

EHRLICHIAL INVASIN FOR IMMUNIZATION, DIAGNOSIS, AND CELL DELIVERY

Ohio State Innovation Fou...

1. A method of treating a subject with Ehrlichiosis, the method comprising: diagnosing Ehrlichiosis in the subject, wherein said diagnosing comprises assaying a biological sample from the subject for the presence of an antibody that specifically binds a polypeptide comprising SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, or a conservative variant thereof having at least 70% identity to SEQ ID NO:7, SEQ ID NO:8, or SEQ ID NO:9, wherein the presence of the antibody is an indication that the subject has been infected with an Ehrlichia sp., and treating the subject diagnosed with Ehrlichiosis accordingly.

US Pat. No. 10,144,052

HOT FORMING OF COOLING GALLERIES IN STEEL PISTONS

Ohio State Innovation Fou...

1. A method for forming a piston having a closed gallery, comprising the steps of:providing a billet of metal;
hot forging the billet, producing a first piston preform having a conical spike atop an underskirt;
hot forming the first piston preform by selectively heating the conical spike and upsetting the first piston preform on a set of horizontal split dies, forming a flange and an undercut that are separated axially by an open gallery that is open in a radial direction, generating a second piston preform without any loss of material;
hot bending the flange in the second piston preform over the open gallery, generating a third piston preform having a closed gallery; and
machining the third piston preform thereby generating a finished piston.

US Pat. No. 10,133,097

ON-CHIP OPTICAL POLARIZATION CONTROLLER

OHIO STATE INNOVATION FOU...

1. An optical polarization controller, comprising:a substantially planar substrate; and
a waveguide unit cell formed on the substantially planar substrate, the waveguide unit cell comprising:
a first out-of-plane waveguide portion, and
a second out-of-plane waveguide portion coupled to the first out-of-plane waveguide portion, wherein each of the first and second out-of-plane waveguide portions respectively includes a core material layer arranged between a first optical cladding layer having a first stress-response property and a second optical cladding layer having a second stress-response property that is different than the first stress-response property such that each of the first and second out-of-plane waveguide portions is deflected by a deflection angle, and wherein the first out-of-plane waveguide portion or the second out-of-plane waveguide portion forms a bend in a direction that is different than a direction of deflection.

US Pat. No. 10,080,899

SYSTEMS AND METHODS FOR TREATING AUTONOMIC INSTABILITY AND MEDICAL CONDITIONS ASSOCIATED THEREWITH

Ohio State Innovation Fou...

1. A closed-loop therapy delivery system for treating autonomic instability or a medical condition associated therewith in a subject, the therapy delivery system comprising:a sensing component configured to detect at least one physiological parameter associated with autonomic instability or the medical condition associated therewith;
a delivery component configured for implantation on or about an autonomic nervous tissue target or a spinal nervous tissue target; and
a controller configured to automatically coordinate operation of the sensing and delivery components;
wherein the controller is programmed to deliver, to the delivery component, an electrical signal that substantially increases sympathetic activity at the autonomic nervous tissue target or a spinal nervous tissue target to effectively treat the autonomic instability or the medical condition associated therewith.

US Pat. No. 10,292,832

SPINAL FIXATION DEVICE

Ohio State Innovation Fou...

13. A spinal fixation device comprising:a housing defining an aperture;
an end plate assembly operatively coupled with the housing, a portion of the end plate assembly pivotable about a pivot pin defining a longitudinal axis, at least a portion of the end plate assembly slidably received within the housing; and
first and second rotatable members operatively coupled with the end plate assembly such that rotation of the first and second rotatable members transitions the spinal fixation device between an expanded state and a contracted state, wherein the first and second rotatable members are configured to engage a first instrument to transition the spinal fixation device between the expanded state and the contracted state, wherein one of the first or second rotatable members is configured to engage a second instrument to adjust an angular orientation of the portion of the end plate assembly.

US Pat. No. 10,279,028

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME

Ohio State Innovation Fou...

1. A composition comprising an inactivated porcine reproductive and respiratory syndrome virus (PRRSV) associated with a nanoparticle, and an adjuvant, wherein the concentration of PRRSV prior to inactivation is from about 1×103 to about 1×107 TCID50.

US Pat. No. 10,174,072

ANTILEISHMANIAL COMPOSITIONS AND METHODS OF USE

Ohio State Innovation Fou...

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having the formula:

wherein each of R4a and R4b is independently selected from hydrogen and C1-C12 alkyl, and each of R6a and R6b is independently selected from hydrogen and C1-C12 alkyl;
or a pharmaceutically acceptable salt, solvate, or polymorph thereof;
wherein the pharmaceutically acceptable carrier is selected from the group consisting of a liposome, nanoparticle, microparticle, cyclodextrin, nanoemulsion, microemulsion, polymersome, surfactant, biocompatible organic solvent, and micelle,
wherein the composition is sterile.
US Pat. No. 10,232,002

ONCOLYTIC HSV1 VECTORS AND METHODS OF USING THE SAME

OHIO STATE INNOVATION FOU...

1. An oncolytic herpes simplex virus deficient for a ?134.5 gene comprising a nucleic acid comprising: a) a nucleotide sequence encoding N-terminal truncated human GADD34 protein, wherein the nucleotide sequence is set forth in SEQ ID NO: 2, wherein said nucleotide sequence is operably linked to an expression control sequence.
US Pat. No. 10,286,068

METHODS TO IMPROVE INDUCTION OF IGA ANTIBODIES BY VACCINES

Ohio State Innovation Fou...

1. A vaccine composition, comprising a vaccine antigen and a neutrophil inhibitor in amounts effective to promote an IgA response to the antigen in a subject, wherein the neutrophil inhibitor comprises sivelestat, alvelestat, elafin, or an inhibitor of phosphodiesterase type 4.

US Pat. No. 10,281,422

DISPLACEMENT CURRENT PHASE TOMOGRAPHY FOR IMAGING OF LOSSY MEDIUM

TECH4IMAGING LLC, Columb...

1. A system for generating a three-dimensional tomograph of a vessel interior or other object, the system comprising:a three-dimensional capacitance sensor device comprising a plurality of electrodes for placement around the vessel or the object, wherein the three-dimensional capacitance sensor device is adapted to provide electric field distribution and sensor sensitivity in three geometric dimensions;
data acquisition electronics in communication with the three-dimensional capacitance sensor device for receiving current output from the three-dimensional capacitance sensor device and for outputting phase data for the current;
a processing system in communication with the data acquisition electronics, the processing system programmed with instructions for executing on the processing system to reconstruct a three-dimensional volume-image from the phase data generated by the data acquisition electronics; and
wherein the plurality of electrodes are configured to be placed around a pipe, tube or object, each electrode comprising a plurality of capacitance plate segments, and wherein the system is further comprised of:
a voltage source; and
wherein the plurality of electrodes is comprised of: a first electrode, having a plurality of capacitance plate segments that are addressable with the voltage source; a second electrode, having a plurality of capacitance plate segments, the capacitance plate segments of the second electrode electrically coupled to the measurement circuit; and wherein the capacitance plate segments of the first electrode form capacitance pairs with at least one of the capacitance plate segments of the second electrode when activated;
and wherein the system is adapted to collect capacitance data by:
defining a capacitor by using a capacitance plate segment on the first electrode as a source electrode, using a capacitance plate segment on the second electrode as a detecting electrode,
charging and discharging the defined capacitor by directing a predetermined voltage to the source electrode from the voltage source;
detecting a capacitance of the defined capacitor by detecting a current induced in the detecting electrode.

US Pat. No. 10,231,618

RAPID MEASUREMENT OF INDIVIDUAL CONE PHOTORECEPTOR POINTING FOR EVALUATION OF EYE HEALTH USING FOCUS DIVERSITY

OHIO STATE INNOVATION FOU...

1. A method of measuring angular direction of individual photoreceptors in an eye, the method comprising:projecting a light from a light source through a pupil of the eye onto a retina of the eye;
capturing an image of light reflected back from a plurality of photoreceptors at a first focal depth;
capturing an image of light reflected back from the plurality of photoreceptors at a second focal depth, the second focal depth being different than the first focal depth;
identifying at least one individual photoreceptor in the image captured at the first focal depth and in the image captured at the second focal depth;
measuring a lateral difference of a position of the identified at least one individual photoreceptor between the image captured at the first focal depth and the image captured at the second focal depth; and
calculating an angular direction of the at least one individual photoreceptor based on the measured lateral difference.

US Pat. No. 10,210,568

COORDINATION OF THERMOSTATICALLY CONTROLLED LOADS WITH UNKNOWN PARAMETERS

Battelle Memorial Institu...

19. A market-based control system configured to coordinate a group of thermostatically controlled loads to achieve system-level objectives with pricing incentives, the system comprising:a market coordinator configured to generate clearing price data based on a plurality of bids specifying a quantity and a price for consuming power;
a plurality of thermostatically controlled loads (TCLs), each of the TCLs being configured to transmit bid data to the market coordinator specifying a bid quantity and a bid price for power received via a power grid for a predetermined time period, the transmitted bid data determined based on an energy response function that relates price data to quantity data for power to be consumed by the load, the energy response function being determined based at least in part on estimating unmeasured parameters for a thermal environment to which each of the respective TCLs is coupled to supply heating or cooling to, each of the TCLs being further configured to consume or not consume power from the power grid based at least in part on the clearing price data and the TCL's respective bid data for the predetermined time period; and
a computer network configured to transmit the bid data and the clearing price data between the market coordinator and each of the TCLs.

US Pat. No. 10,293,234

IMPACT ABSORBING MECHANISM

Ohio State Innovation Fou...

1. A strike-absorbing apparatus for receiving a strike from a person, the apparatus comprising:(a) a striking portion configured to receive strikes;
(b) a mounting portion removably mounted to a substantially vertical post of a squat rack having at least one aperture; and
(c) an energy-absorbing portion disposed between, and mounted to, the striking portion and the mounting portion, wherein an elongated insert extends slidably into a barrel formed in an elongated sleeve, wherein the barrel defines a chamber in which a spring is mounted for compression when the elongated insert extends into the barrel, wherein the striking portion mounts at a first end of the energy-absorbing portion, and the mounting portion mounts at a second, opposite end of the energy-absorbing portion, wherein the mounting portion includes:
(i) a plate that seats against a first side of the vertical post;
(ii) a bracket that is disposed adjacent a second, opposite side of the vertical post and removably mounts to the plate, thereby clamping the vertical post between the plate and the bracket; and
(iii) an adapting insert that is disposed between the bracket and at least the second side of the vertical post to seat against the second side.
US Pat. No. 10,227,409

CS1-SPECIFIC CHIMERIC ANTIGEN RECEPTOR ENGINEERED IMMUNE EFFECTOR CELLS

Ohio State Innovation Fou...

1. A method of providing an anti-tumor immunity in a subject with multiple myeloma (MM), the method comprising administering to the subject an effective amount of an immune effector cell genetically modified to express a chimeric antigen receptor (CAR) wherein the CAR comprises a CS1 antigen binding domain, a costimulatory signaling region, and an intracellular signaling domain, thereby providing an anti-tumor immunity in the subject; wherein the CS1 antigen binding domain comprises a single-chain variable fragment (scFv) of an antibody that specifically binds CS1.

US Pat. No. 10,201,706

SYSTEMS AND METHODS OF IMPROVING AN INFLAMMATORY DISORDER

Ohio State Innovation Fou...

1. A method of improving an inflammatory disorder in a subject suffering therefrom comprising:positioning a therapy delivery device in communication with a neural target site, comprising at least a part of the enteric nervous system, that contributes to immune activity of the subject;
sensing, by at least one of an electrical sensor and a biological sensor, at least one physiological parameter of immune activity of the enteric nervous system that is indicative of an inflammatory disorder of the subject, wherein the at least one of the electrical sensor and biological sensor is disposed at an enteric plexus or ganglion;
delivering, by the therapy delivery device, a therapy signal to the neural target site, wherein delivery parameters of the therapy signal are selected based on the sensed at least one physiological parameter to modulate an immune response of the subject to treat the subject's inflammatory disorder.

US Pat. No. 10,193,547

DRIVER SYSTEM WITH AN OPTICAL POWER BASED ISOLATED POWER SUPPLY

OHIO STATE INNOVATION FOU...

1. A driver system comprising:a plurality of optical receivers, wherein a first optical receiver of the plurality of optical receivers is configured to receive an optical power signal generated by a first optical transmitter of a plurality of optical transmitters over a first transmission medium, and wherein a second optical receiver of the plurality of optical receivers is configured to receive and an optical data signal generated by a second optical transmitter of the plurality of optical transmitters over a second transmission medium;
wherein the first optical receiver is coupled to the first optical transmitter via a first optical fiber corresponding to the first transmission medium, and the second optical receiver is coupled to the second optical transmitter via a second optical fiber corresponding to the second transmission medium;
wherein the first optical receiver is configured to convert the optical power signal to an electrical power signal comprising a given drive strength; and
a driving circuit configured to apply the electrical power signal to an input of a transistor device to drive the transistor device at the given drive strength according to a control signal, wherein the control signal defines an on-time and an off-time for the driving circuit over a given time interval.

US Pat. No. 10,188,989

ELECTROOSMOTIC DEVICES FOR FLUID HANDLING

Ohio State Innovation Fou...

1. A device comprising:(a) a nanoporous membrane having a top surface and a bottom surface;
(b) a fluid source positioned in fluid contact with the bottom surface of the nanoporous membrane; and
(c) a porous electrode patterned on one of the top or bottom surfaces of the nanoporous membrane so as to define a fluid delivery region in fluid contact with the top surface of the nanoporous membrane;
wherein the porous electrode is configured such that, upon application of a potential bias across the nanoporous membrane, fluid flow is induced between the fluid source and the fluid delivery region.

US Pat. No. 10,134,979

STRONTIUM OXIDE AS A TUNNEL BARRIER FOR SPIN INJECTION AND GIANT SPIN ACCUMULATION

Ohio State Innovation Fou...

1. A spintronic device comprising:a spin current transport layer;
a first spin injector comprising:
a first tunnel barrier layer made of strontium oxide (SrO) disposed over the spin current transport layer;
a first magnetic material layer disposed over the first tunnel barrier layer; and
a spin detector comprising:
a second tunnel barrier layer made of SrO disposed over the spin current transport layer;
a second magnetic material layer disposed over the second tunnel barrier layer; and
a spin sensor having a spin input terminal coupled to the second magnetic material layer, wherein the spin injector and the spin transport layer are configured to achieve a spin relaxation time of at least 2 nanoseconds for an injected spin current of 10 microamperes per meter square.

US Pat. No. 10,258,246

DIRECT INVERSION FOR PHASE-BASED DYNAMIC MAGNETIC RESONANCE MEASUREMENTS

Ohio State Innovation Fou...

1. A method of recovering time-resolved velocity from a phase-contrast magnetic resonance imaging (MRI) data set, comprising:acquiring a MRI data set using a magnetic resonance imaging (MRI) device using a balanced four-point acquisition (BFPA);
using a processor of a computing device to perform:
reconstructing a phase encoding matrix (B) based on a velocity encoding sequence used to determine the phase-contrast MRI data set;
constructing an operator (R) as a regularization operator;
reading an image phase (?) along a temporal dimension at a pixel or voxel;
estimating a velocity phase vector (?) along a temporal dimension using a relationship:

scaling the estimated velocity phase vector (?) to a velocity vector profile; and
generating distortion-free velocity images from the velocity vector profile,
wherein ?b, ?x, ?y, and ?z control an extent of regularization for background, x, y, and z components of the velocity phase vector (?), respectively,
wherein Rb, Rx, Ry, and Rz are each linear operators that indicate that the regularization is acting only on the background x, y, and z components of the velocity phase vector (?), respectively, and
wherein
with user defined constant, c, controlling the net regularization strength and ?>0 guiding the ratio between ?b, ?x, ?y, and ?z to adaptively adjust regularization strength for each component of ?.

US Pat. No. 10,546,572

FOLDED TRANSDUCER ARRAY FOR COMPACT AND DEPLOYABLE WAVE-ENERGY GUIDING SYSTEM

OHIO STATE INNOVATION FOU...

1. A wave-energy guiding system comprising:a structural substrate formed according to a folded-pattern topology, the structural substrate including a plurality of planar facets each coordinatedly positionable at an adjustable angle relative to adjacent planar facets, wherein an adjustment of the adjustable angle between two adjacent planar facets causes a corresponding adjustment of the adjustable angle between two other adjacent planar facets; and
a plurality of transducers each coupled to a different planar facet of the plurality of planar facets of the structural substrate, wherein the folded-pattern topology and positioning of the plurality of transducers on the plurality of planar facets is configured to cause adjustments to a degree of folding of the structural substrate in the folded-pattern topology to produce a corresponding adjustment in a directional characteristic and a focusing characteristic of the wave-energy guiding system.

US Pat. No. 10,345,408

LOW FIELD MAGNETIC RESONANCE IMAGING (MRI) SCANNER FOR CARDIAC IMAGING

Ohio State Innovation Fou...

1. A method for reconstructing image data, comprising:determining a noise power of acquired k-space data;
determining coil-sensitivity maps;
initializing values of relative weights that are respectively applied to subdictionaries used to model an image;
using the coil-sensitivity maps and values of the relative weights to iteratively minimize a weighted l1-norm of image representation in the subdictionaries in accordance with the relative weights;
updating, within each iteration, the relative weights of subdictionaries based on a subdictionary-specific maximizing of a likelihood function; and
outputting reconstructed images upon convergence of a cost function used to estimate the reconstructed images.

US Pat. No. 10,247,288

CIRCULAR WAVE DRIVE

OHIO STATE INNOVATION FOU...

1. A circular wave drive, comprising:a substantially enclosed housing having a chamber therein,
wherein the periphery of the chamber is defined by a circular wall,
wherein the circular wall includes an inner diameter, and
wherein the circular wall includes a friction element;
a ring-shaped wheel residing in the chamber,
wherein the ring-shaped wheel includes both an external friction element and an internal friction element,
wherein the ring-shaped wheel includes a hollow central portion including an inner wall having an inner diameter, the inner wall including the internal friction element,
wherein the ring-shaped wheel includes an outer diameter, and
wherein the ring-shaped wheel outer diameter is less than the inner diameter of the circular wall;
a wave generator having a wheel-driving portion that is oriented within the hollow central portion of the ring-shaped wheel,
wherein the wave generator includes an eccentrically mounted input shaft extending from the wheel-driving portion and through the housing; and
an output element having a wheel-driven portion that is oriented within the hollow central portion of the ring-shaped wheel opposite the wheel-driving portion of the wave generator,
wherein the output element includes an input shaft that extends from the wheel-driven portion and through the housing in an opposite direction of the input shaft of the wave generator, and
wherein a peripheral face of the wheel-driven portion includes a friction element being in contact with the internal friction element of the ring-shaped wheel.

US Pat. No. 10,433,554

DEODORIZING COMPOUNDS, COMPOSITIONS, AND METHODS FOR REPELLING INSECTS

Ohio State Innovation Fou...

1. A method of repelling an insect, comprising applying to a subject a composition in an amount effective to repel said insect; wherein said composition comprises Formula I:
wherein R comprises a mixture of C16-C18 unsubstituted alkyl and C16-C18 unsubstituted alkenyl groups; and
wherein the composition does not comprise thymol or carvacrol.

US Pat. No. 10,380,788

FAST AND PRECISE OBJECT ALIGNMENT AND 3D SHAPE RECONSTRUCTION FROM A SINGLE 2D IMAGE

OHIO STATE INNOVATION FOU...

1. A computer-implemented method for mapping a computerized 2D image into a 3D shape comprising:applying machine learning to a predetermined sample size of computerized 2D images, that application developing two criteria, a detection criterion and a transform criterion for a multi-layer deep neural network (“DNN”),
receiving a non-sample computerized 2D image through a detector of the DNN that has been trained by the application of machine learning,
regressing, with the detection criterion, the non-sample image that yields detected landmark points through the DNN
recovering, with the transform criterion, depth information from image attributes; and
mapping, with the transform criterion, the landmark points through linear or nonlinear functions of the DNN that yield a 3D shape corresponding to the non-sample image.
US Pat. No. 10,369,176

PROBIOTIC FORMULATIONS AND METHODS FOR USE

Ohio State Innovation Fou...

1. A composition comprising a biocompatible microsphere, a prebiotic, and a biofilm-generating probiotic bacterium that releases a DNABII protein, wherein the prebiotic comprises an effective amount of a nutritional supplementation for the probiotic bacterium to support the formation of a biofilm, and wherein the prebiotic diffuses from within the microsphere.

US Pat. No. 10,357,151

METHOD OF IDENTIFYING AND EYE DISORDER OF AN OBSERVER AND APPARATUS FOR IMPLEMENTING THE SAME

OHIO STATE INNOVATION FOU...

1. A method of identifying an eye disorder of an observer, the method being accomplished with an apparatus comprising a display, a user interface, and a processor, the method comprising:the display generating first stimuli for the observer while an untested eye of the observer is covered with a translucent medium, the first stimuli being generated as part of a first trial for a tested eye of the observer;
the display generating second stimuli for the observer while the untested eye of the observer is covered with an at least substantially opaque medium, the second stimuli being generated as part of a second trial for the tested eye;
the user interface receiving first input for the first trial;
the user interface receiving second input for the second trial;
the processor determining a first contrast sensitivity function (CSF) using the first input;
the processor determining a second contrast sensitivity function (CSF) using the second input;
the processor calculating a first area under contrast sensitivity function (AUCSF) for the first CSF;
the processor calculating a second area under contrast sensitivity function (AUCSF) for the second CSF;
the processor defining an inhibition index for the first and second trials as the ratio of the first AUCSF over the second AUCSF or as the ratio of the second AUCSF over the first AUCSF;
the processor identifying an eye disorder for the tested eye of the observer using the inhibition index.
US Pat. No. 10,393,741

COMPOSITIONS AND METHODS FOR THE DETECTION OF ANAPLASMA PLATYS

Ohio State Innovation Fou...

1. A method for diagnosing an infection with Anaplasma platys in a subject comprising the steps of: (a) providing a test sample from the subject; (b) providing an isolated or purified P44 protein of Anaplasma platys; (c) contacting the test sample with the P44 protein; and (d) assaying for the formation of a complex between antibodies in the test sample and the P44 protein, wherein formation of said complex is indicative of infection with Anaplasma platys, wherein the Anaplasma platys P44 protein comprises SEQ ID NO: 39, SEQ ID NO: 92 or SEQ ID NO:44.

US Pat. No. 10,383,654

METHODS AND SYSTEMS FOR PERFORMING NAVIGATION-ASSISTED MEDICAL PROCEDURES

Ohio State Innovation Fou...

1. A system for providing feedback on a position of a tool in relation to an item of interest during medical procedures comprising:a medical imaging device that acquires image information of an item of interest located within at least a portion of a subject using targeted or non-targeted techniques;
a tool comprising a sensor, wherein the sensor senses position and orientation information of the tool;
a programmable processor that executes computer-readable instructions in communication with the medical imaging device and the sensor, wherein the processor:
receives the acquired image information of the item of interest from the medical imaging device;
estimates location information of the item of interest located within at least the portion of the subject using an algorithmic deformation model based on the acquired image information to estimate unobserved motion of the item of interest within at least the portion of the subject;
receives the position and orientation information of the tool from the sensor;
determines a relative position of the tool to the item of interest using the location information of the item of interest and the position and orientation information of the tool; and
provides directional and distance active feedback based on the relative position of the tool to the item of interest, wherein the active feedback is used to change the relative position of the tool to the item of interest during a navigation-assisted medical procedure, wherein the active feedback changes as the moveable device moves closer to or further away from the item of interest, and wherein the distance active feedback comprises distance encoded vibration frequencies provided through the tool.
US Pat. No. 10,201,526

COMPOSITIONS AND METHODS FOR INHIBITING THE GROWTH OF NEISSERIA GONORRHOEAE

Ohio State Innovation Fou...

1. A method of reducing the amount of viable Neisseria gonorrhoeae in a human having a cervical epithelial cell infection with Neisseria gonorrhoeae comprising administering 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-2-yl)phenyl)acetamide (AR-12) to a human infected with Neisseria gonorrhoeae.

US Pat. No. 10,307,520

SYSTEMS AND METHODS FOR MECHANICAL DISPLACEMENT OF AN ESOPHAGUS

Ohio State Innovation Fou...

1. An assembly for use with a vacuum system and an esophageal positioning device, the esophageal positioning device comprising a handle, a first segment coupled to the handle, a second segment pivotally connected to the first segment via an articulation pivot pin, and at least one articulation drive cable that pivots the second segment about the first segment between a first position and a second position upon articulation, wherein the first segment has a central axis and the second segment has a distal end, wherein the distal end of the second segment is disposed along the central axis in the first position and the distal end of the second segment is displaced from the central axis in the second position, the assembly comprising:an introducer comprising:
a soft outer tube sized to pass through a mouth or nasal passage into an esophagus, the soft outer tube comprising a distal end, a proximal end, a lumen, and a body, wherein the body defines a plurality of radial vacuum holes spaced circumferentially around the soft outer tube and one or more internal vacuum passages that extend a distance from the proximal end towards the distal end within the body of the outer tube, wherein the one or more internal vacuum passages are in fluid communication with the plurality of vacuum holes to apply a vacuum to an esophageal wall via the vacuum system; and
a tube tip located at the distal end of the outer tube,
wherein the distal end of the second segment remains a same distance from the articulation pivot pin in the first position and the second position.

US Pat. No. 10,589,216

MEMBRANES FOR FLUID SEPARATION

Ohio State Innovation Fou...

1. A method of making alumino-silicate nanoparticles comprising:(a) heating a first mixture comprising a silicon source, an aluminum source, a base, an organic agent, and a first solvent to produce a first population of alumino-silicate nanoparticles dispersed in a first supernatant;
(b) separating the first population of inorganic nanoparticles from the first supernatant;
(c) adding a base to the first supernatant to form a second mixture;
(d) heating the second mixture to produce a second population of alumino-silicate nanoparticles dispersed in a second supernatant; and
(e) separating the second population of inorganic nanoparticles from the second supernatant;
wherein the method comprises repeating steps (c) and (d) prior to performing step (e); and
wherein the first population of alumino-silicate nanoparticles and the second population of alumino-silicate nanoparticles each have an average particle size of 100 nm or less.

US Pat. No. 10,466,188

THERMAL SIMULATOR

OHIO STATE INNOVATION FOU...

1. A thermal simulator, comprising:a first body formed of a first material, said first material having a first heat capacity, a first density, and a first thermal conductivity;
a first thermometric device positioned within said first body; and
a first communication device for transmitting a first temperature, measured within said first body by said first thermometric device, to a position outside of said first body.

US Pat. No. 10,451,751

CHARGE GENERATING DEVICES AND METHODS OF MAKING AND USE THEREOF

Ohio State Innovation Fou...

1. A charge generating device comprising:a substrate having a top surface and a bottom surface;
a plurality of spaced-apart three-dimensional elements disposed on the top surface of the substrate;
a plurality of cavities formed by the plurality of spaced-apart three-dimensional elements, the plurality of cavities being the area between the plurality of spaced-apart three-dimensional elements;
a radioactive layer disposed on at least a portion of the plurality of spaced-apart three-dimensional elements and the top surface such that the plurality of cavities and the top surface are substantially coated by the radioactive layer, thereby forming a plurality of coated cavities;
a first conducting layer disposed above the plurality of spaced-apart three-dimensional elements, wherein the first conducting layer is in electric contact with at least a portion of the plurality of spaced-apart three-dimensional elements;
a second conducting layer disposed below the substrate, wherein the second conducting layer is in electric contact with the bottom surface of the substrate;
a first scintillation layer disposed above the first conducting layer and in radiative contact with the first conducting layer; and
a second scintillation layer disposed below the second conducting layer and in radiative contact with the second conducting layer.
US Pat. No. 10,420,825

EHRLICHIAL INVASIN FOR IMMUNIZATION, DIAGNOSIS, AND CELL DELIVERY

Ohio State Innovation Fou...

1. A vaccine, comprisingone or more polypeptides comprising an amino acid sequence having at least 70% identity to an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, or an immunogenic fragment thereof capable of eliciting an immune response against an Ehrlichia sp.; and
a pharmaceutically acceptable adjuvant.

US Pat. No. 10,324,355

DEVICES AND METHODS FOR IMPLEMENTING AN OPTICAL SWITCHING ENGINE

OHIO STATE INNOVATION FOU...

1. A multiple bounce optical cell comprising:optical components arranged to reflect an array of light beams received at an input plane through a plurality of bounces, wherein each bounce is defined by a sub-set of the optical components including:
a lens;
a pixelated polarization-controlling spatial light modulator (SLM) disposed at a front focal plane of the lens and having pixels controlling polarization states of the light beams of the array of light beams landing on the pixels;
at least one mirror disposed at a back focal plane of the lens and arranged to reflect the array of light beams received from the SLM via the lens back through the lens to a next SLM of the next bounce of the plurality of bounces or to an output plane; and
a polarization grating (PG) disposed in an optical path of the array of light beams between the SLM and the at least one mirror.

US Pat. No. 10,292,891

ACTIVE ROBOTIC WALKER AND ASSOCIATED METHOD

Ohio State Innovation Fou...

1. A robotic walker comprising:a frame having a front and a back;
a pair of motorized drive wheels configured to support the front of the frame;
a pair of wheels configured to support the back of the frame;
a housing mounted on the frame, the housing containing a control unit operatively connected to a drive unit, the housing further containing a power supply operatively connected to the control unit and the drive unit; the drive unit being operatively connected to the pair of motorized drive wheels;
first and second winches mounted on the frame, each first and second winch having a strap that can be retracted by its respective winch, each winch being operatively connected to the drive unit, each strap having an end adapted to be removably connected to a pair of leg braces worn by a user;
a stop-motion limit member affixed to each strap from the respective first and second winches;
first and second sensing devices associated with respective first and second winches, each sensing device being configured to stop the retraction of the respective straps by the first and second winches when the stop-motion limit member engages the respective sensing device; and
a first control button operatively connected to the control unit,
wherein the control unit is configured to operate the robotic walker in at least one control mode and the first control button being operable to start the at least one control mode.
US Pat. No. 10,238,629

METHODS FOR REDUCING THE OCCURRENCE OF HOT FLASHES

Ohio State Innovation Fou...

1. A method to ameliorate one or more symptoms of perimenopause or menopause in a subject having perimenopause or menopause, or to ameliorate hot flashes in a subject receiving androgen deprivation therapy, comprising:a) administering to the subject having symptoms of perimenopause or menopause, or to the subject receiving androgen deprivation therapy, a tocotrienol formulation comprising at least 10% alpha-tocopherol, at least 12% alpha-tocotrienols, at least 20.6% gamma-tocotrienols, at least 1.5% beta-tocotrienols, and at least 5% delta-tocotrienols; and
b) ameliorating the symptoms of perimenopause or menopause in the subject having perimenopause or menopause, or ameliorating hot flashes in the subject receiving androgen deprivation therapy.

US Pat. No. 10,194,826

ADAPTIVE ELECTRICAL CAPACITANCE VOLUME TOMOGRAPHY

Ohio State Innovation Fou...

1. A system for tomographic imaging of a domain in a pipe, tube or object, the system comprising:a sensor, comprising:
a plurality of electrodes configured to be placed around the pipe, tube or object, each electrode comprising a plurality of capacitance plate segments; and
a voltage source;
a measurement circuit electrically coupled to the sensor;
wherein the plurality of electrodes is comprised of: a first electrode, having a plurality of capacitance plate segments that are addressable with the voltage source; a second electrode, having a plurality of capacitance plate segments, the capacitance plate segments of the second electrode electrically coupled to the measurement circuit; and wherein the capacitance plate segments of the first electrode form capacitance pairs with at least one of the capacitance plate segments of the second electrode when activated;
and wherein the system is adapted to collect capacitance data by:
defining a capacitor by using a capacitance plate segment on the first electrode as a source electrode, using a capacitance plate segment on the second electrode as a detecting electrode,
charging and discharging the defined capacitor by directing a predetermined voltage to the source electrode from the voltage source;
detecting a capacitance of the defined capacitor by detecting a current induced in the detecting electrode;
an image reconstruction processor, in communication with the measurement circuit, wherein the image reconstruction processors is adapted to convert detected capacitance data into an image; and
wherein the system is adapted to activate various combinations of electrodes with different voltage distributions or envelopes to provide control of system sensitivity.

US Pat. No. 10,387,746

IMAGE COLOR DATA NORMALIZATION AND COLOR MATCHING SYSTEM FOR TRANSLUCENT MATERIAL

Ohio State Innovation Fou...

1. A method for color matching of translucent materials, comprising:acquiring one or more images of a region of interest using a digital imaging device;
applying regression modeling to convert an acquired Red, Green and Blue (RGB) color space value to spectral radiance, spectral reflectivity, absorption, scattering, CIELAB color coordinates, CIELAB XYZ tristimulus values, or any units of the CIE color space while to normalize the RGB color space value to spectroradiometric accuracy;
comparing the converted values to master shade specimen data contained in a database;
selecting one of the master shade specimens that best matches the spectral radiance, spectral reflectivity, absorption, scattering, CIELAB color coordinates, CIELAB XYZ tristimulus values, or any units of the CIE color space value by having a smallest CIEDE2000 color difference relative to the CIELAB color space value of the region of interest, the color difference being further determined in accordance with blending effects by subtracting the overall color difference (?E R3:R0) from the color difference due to layering (?E TO:TL) in accordance with the relationships:
Color Difference=color differencelayering?color differenceblending
Color Difference=?E R3:R0
color differencelayering=?E TO:TL
color differenceblending=?E TO:TL??E R3:R0
wherein an overall color difference between an inner and an outer was defined as ?E R3:R0, wherein a color difference due to layering is defined as ?E TO:TL; and
presenting an indication of the selected one of the master shade specimens to a user in a user interface.

US Pat. No. 10,268,940

STRETCHABLE BROAD IMPEDANCE BANDWIDTH RFID DEVICES

OHIO STATE INNOVATION FOU...

1. A stretchable RFID device comprising:an RFID chip; and
an RFID antenna electrically coupled and mechanically attached to the RFID chip, wherein the RFID antenna is impedance matched to the RFID chip across a broad bandwidth and comprises two arms and two end-loading bodies each electrically-coupled and mechanically attached to a distal end of each of the two arms, said distal end of each arm offset from the RFID chip, wherein each end-loading body comprises a contour without sharp corners having a lateral distance and an orthogonal distance such that the contour at least partially defines an end-loading orifice, and wherein the orthogonal distance of the contour comprising the end-loading body decreases and the lateral distance of the contour comprising the end-loading body increases when the stretchable RFID device is stretched in a lateral direction.

US Pat. No. 10,655,121

GALVANOTAXIS ASSAY FOR QUANTITATIVE ASSESSMENT OF METASTATIC POTENTIAL OF CANCER CELLS

Ohio State Innovation Fou...

1. A system for controlling metastasis comprised of:a function generator;
a first row of a plurality of assay wells;
a second row of a plurality of assay wells;
an electromagnetic coil operably connected to the function generator and placed in between the first and second rows of assay wells and adjacent to each of the plurality of assay wells, the electromagnetic coil having a first end and a second end and wherein the electromagnetic coil induces an electric field when a waveform is applied to the electromagnetic coil by the function generator;
a plurality of well inserts each having a porous membrane, wherein each of the plurality of well inserts are adapted for placement into one of the plurality of assay wells so that each of the assay wells are divided into a lower and upper compartment; and
wherein the waveform induces an electric field across each of the porous membranes of each of the well inserts when placed in each of the plurality of assay wells.

US Pat. No. 10,436,978

INTERNAL CLADDING IN SAPPHIRE OPTICAL DEVICE AND METHOD OF MAKING SAME

Ohio State Innovation Fou...

1. A sapphire optical fiber having an azimuthally uniform internal refractive cladding within the sapphire optical fiber, wherein the sapphire optical fiber is a graded index sapphire optical fiber.
US Pat. No. 10,358,494

CS1-SPECIFIC CHIMERIC ANTIGEN RECEPTOR ENGINEERED IMMUNE EFFECTOR CELLS

Ohio State Innovation Fou...

1. A chimeric antigen receptor (CAR) polypeptide, comprising a CS1 antigen binding domain, a transmembrane domain, an intracellular signaling domain, and a co-stimulatory signaling region, wherein the CS1 antigen binding domain consists of one single-chain variable fragment (scFv) of an antibody that specifically binds CS1.