US Pat. No. 9,293,543

FILM FORMING METHOD AND FILM FORMING APPARATUS

TOKYO ELECTRON LIMITED, ...

1. A method of forming a gate insulating film for use in a MOSFET for a power device, the method comprising:
forming an AlN film;
forming an AlO film; and
repeating the forming the AlN film and the forming the AlO film, thereby forming an AlON film having a laminated structure
in which AlO films and AlN films are alternately laminated.

US Pat. No. 9,234,934

INSPECTING DEVICE AND INSPECTING METHOD

SCREEN HOLDINGS CO., LTD....

1. An inspecting device for inspecting a photo device comprising:
an irradiation part for irradiating said photo device with pulsed light;
a detection part having a detector for detecting an electric field intensity of an electromagnetic wave pulse depending on
irradiation with probe light emitted from a light source for said pulsed light;

a delay part for changing a time difference between a time that said electromagnetic wave pulse arrives at said detector and
a time that said probe light arrives at said detector, thereby delaying a timing for detecting said electromagnetic wave pulse
through said detector;

a temporal waveform restoration part for restoring a temporal waveform of said electromagnetic wave pulse based on said electric
field intensity of said electromagnetic wave pulse detected by said detector in said plurality of pieces of detection timing;

an electromagnetic wave pulse analysis part for detecting a negative peak of said electric field intensity in said temporal
waveform, and

a setting part for setting a detection timing for detecting said electromagnetic wave pulse radiated from said photo device
through said detector, based on the detection timing for detecting said negative peak in said temporal waveform.

US Pat. No. 9,096,950

NITRIDE CRYSTAL AND METHOD FOR PRODUCING THE SAME

RICOH COMPANY, LTD., Tok...

1. A nitride crystal which encircles an outer periphery of a seed crystal, the nitride crystal comprising:
first partial regions, and
second partial regions, each second partial region being a plane region positioned between two of the first partial regions
and having optical characteristics different from those of the first partial regions.

US Pat. No. 9,188,742

TERAHERZ-WAVE CONNECTOR AND TERAHERZ-WAVE INTEGRATED CIRCUITS, AND WAVE GUIDE AND ANTENNA STRUCTURE

ROHM CO., LTD., Kyoto (J...

1. A terahertz-wave connector, comprising:
a two dimensional photonic crystal slab;
lattice points periodically arranged in the slab, the lattice points for diffracting terahertz waves in photonic bandgap frequencies
of photonic band structure of the slab in order to prohibit existence of the terahertz waves in a plane of the slab;

a two dimensional photonic crystal waveguide disposed in the slab and formed with a line defect of the lattice points; and
an adiabatic mode converter disposed at an edge face of the slab to which the waveguide extended, the waveguide extended to
the adiabatic mode converter, wherein

the adiabatic mode converter, in a planar view of the slab, may have a tapered shape so that a tip part becomes thinner as
being distanced from the edge face of the slab, and a side surface of the tapered shape has an inclined plane.

US Pat. No. 9,383,321

INSPECTION APPARATUS AND INSPECTION METHOD

SCREEN HOLDINGS CO., LTD....

1. An inspection apparatus for inspecting a photoelectric device, the inspection apparatus comprising:
an excitation light irradiation part for irradiating said photoelectric device with excitation light for causing said photoelectric
device to radiate a terahertz wave;

a detection part for detecting the terahertz wave radiated from said photoelectric device in response to irradiation with
said excitation light;

a temperature changing part for changing a temperature of said photoelectric device at a part irradiated with said excitation
light;

a storage part for storing temperature correlation information regarding a correlation between a temperature of said photoelectric
device and an intensity of said terahertz wave radiated from said photoelectric device in response to irradiation with said
excitation light,

wherein said temperature correlation information is obtained by changing the temperature of said photoelectric device by said
temperature changing part, and collecting intensities of said terahertz wave radiated from said photoelectric device at respective
temperatures; and

a correction part for correcting an intensity of said terahertz wave detected by said detection part based on a temperature
of said photoelectric device obtained by a temperature measuring part and said temperature correlation information.

US Pat. No. 9,464,093

SUBSTITUTED IMIDAZO[4',5':4,5]CYCLOPENTA[1,2-E]PYRROLO[1,2-A]PYRAZINES AND OXAZOLO[4',5':4,5]CYCLOPENTA[1,2-E]PYRROLO[1,2-A]PYRAZINES FOR TREATING BRAIN CANCER

Mayo Foundation for Medic...

8. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

US Pat. No. 9,281,740

POWER CONVERSION APPARATUS

TOSHIBA MITSUBISHI-ELECTR...

1. A power conversion apparatus converting DC power supplied from a DC power supply having a first electrode and a second
electrode into AC power for supply to a load, said power conversion apparatus comprising:
an AC terminal for outputting said AC power,
a first DC division capacitor and a second DC division capacitor connected in series between said first electrode and said
second electrode,

a first main switch having a first end coupled to said first electrode of said DC power supply, and a second end coupled to
said load,

a first main diode connected in parallel with said first main switch, so as to have a conducting direction opposite to the
conducting direction of said first main switch,

a second main switch having a first end coupled to a second end of said first main switch, and a second end coupled to said
second electrode of said DC power supply, and provided so as to have a conducting direction identical to the conducting direction
of said first main switch,

a second main diode connected in parallel with said second main switch, so as to have a conducting direction opposite to the
conducting direction of said second main switch,

a first snubber capacitor and a second snubber capacitor,
a first snubber diode and a second snubber diode connected in series between said first snubber capacitor and said second
snubber capacitor,

a protection circuit for causing, when voltage applied to said first snubber capacitor becomes greater than or equal to a
predetermined value or when voltage applied to said second snubber capacitor becomes greater than or equal to a predetermined
value, a charging current formerly flowing from said DC power supply to said first snubber capacitor or said second snubber
capacitor to flow to another current path, and

a control circuit controlling said first main switch and said second main switch to be turned on and off,
said first snubber capacitor provided between an anode of said first main diode and a cathode of said first snubber diode,
said second snubber capacitor provided between a cathode of said second main diode and an anode of said second snubber diode,
said protection circuit including
a transformer, and
a first clamp diode and a second clamp diode connected in parallel with said first main switch and said second main switch,
and provided between said first electrode and said second electrode, so as to have a conducting direction opposite to the
conducting direction of said first main switch and said second main switch,

said transformer including
a first primary winding and a second primary winding connected in series, and
a first secondary winding and a second secondary winding provided corresponding to said first and second primary windings,
respectively,

a connection node of said first primary winding and said second primary winding being connected to said AC terminal, and
a coupling node of a first unit having said first clamp diode and said first secondary winding connected in series and a second
unit having said second clamp diode and said second secondary winding connected in series being connected to a connection
node of said first DC division capacitor and said second DC division capacitor.

US Pat. No. 9,620,286

INSULATING MATERIAL, PASSIVE ELEMENT, CIRCUIT BOARD, AND METHOD OF MANUFACTURING AN INSULATING SHEET

NIPPON MEKTRON, LTD., To...

1. An insulating material comprising a fiber assembly mainly composed of a cellulose nanofiber, and an electroconductive metal
material supported by the fiber assembly, wherein the electroconductive metal material is fibrous, and the fibrous electroconductive
metal material, supported by 100 g of cellulose nanofiber, has a total length of 1×10?7 m or longer and 5×10?8 m or shorter.

US Pat. No. 9,576,731

INSULATING MATERIAL, PASSIVE ELEMENT, CIRCUIT BOARD, AND METHOD OF MANUFACTURING AN INSULATING SHEET

NIPPON MEKTRON, LTD., To...

1. An insulating material comprising a fiber assembly mainly composed of a cellulose nanofiber, and an electroconductive metal
material supported by the fiber assembly, wherein the electroconductive metal material is fibrous, and the fibrous electroconductive
metal material, supported by 100 g of cellulose nanofiber, has a total length of 1×10?7 m or longer and 5×10?8 m or shorter.

US Pat. No. 9,450,536

INSPECTION APPARATUS AND INSPECTION METHOD

SCREEN HOLDINGS CO., LTD....

1. An inspection apparatus that inspects a photo device, the inspection apparatus comprising:
an irradiation part that emits a plurality of pieces of pulse light having different wavelengths to irradiate a photo device;
a setting part that sets said wavelengths of said plurality of pieces of pulse light with which said photo device is irradiated
by said irradiation part; and

a detection part that detects an electric field intensity of an electromagnetic wave emitted from said photo device in response
to said plurality of pieces of pulse light with which said photo device is irradiated by said irradiation part, wherein

said irradiation part irradiates said photo device with pulse light having a second wavelength different from a first wavelength
after a time ?t elapses since said photo device is irradiated with pulse light having said first wavelength, and

said time ?t is longer than a generation time for one pulse of said electromagnetic wave emitted by said pulse light.

US Pat. No. 9,807,889

METHOD OF MOUNTING ELECTRONIC COMPONENT TO CIRCUIT BOARD

OSAKA UNIVERSITY, Osaka ...

1. A method of mounting electronic component, the method comprising the steps of:
providing a conductive layer on at least one wiring disposed on a surface of a printed wiring board, the conductive layer
being formed of a solder powder-containing resin composition containing thermosetting resin, solder powder, and a reducing
agent;

providing a thermoplastic resin layer, which is formed of thermoplastic resin, on the conductive layer such that the thermoplastic
resin layer covers the conductive layer, and directly on a portion of the surface of the printed wiring board positioned next
to the wiring in a direction parallel with the surface of the printed wiring board;

disposing an electronic component on the conductive layer such that the thermoplastic resin layer is positioned between the
conductive layer and the electronic component; and

electrically connecting the electronic component to the wiring through the conductive layer by heating the conductive layer
and the thermoplastic resin layer to a melting point or higher of the solder powder.

US Pat. No. 9,733,369

NEUTRON MONITOR DEVICE AND NEUTRON MEASUREMENT METHOD

MITSUBISHI HEAVY INDUSTRI...

1. A neutron monitor device comprising:
a first detector which includes a first body including a spherical portion of a predetermined radius formed of a hydrogen-containing
material, a first specimen containing Ga disposed at the center of the spherical portion, a Cd layer provided on an outer
surface of the spherical portion, and a B layer provided around the first specimen; and

a second detector which includes a second body that is formed of a hydrogen-containing material and includes a spherical portion
having a radius different from the radius of the spherical portion of the first detector, a second specimen containing Ga
disposed at the center of the spherical portion, a B layer provided on the outer surface of the spherical portion, and a Cd
layer provided around the second specimen.

US Pat. No. 9,636,692

LIQUID METAL TARGET FORMING APPARATUS

MITSUBISHI HEAVY INDUSTRI...

1. A neutron generator, comprising
an accelerator that irradiates with a proton beam,
a nozzle that forms a liquid metal target in space, which is irradiated with the proton beam, by ejecting liquid metal thereto,
a receiving portion that faces the nozzle, the receiving portion receives the liquid metal target from the nozzle,
a portion which forms a part of a region in a discharge port of the nozzle has an elongated shape wherein at least one long
side of the discharge port of the nozzle has a cyclical concavo-convex shape; wherein

generating neutrons by receiving the proton beam between the nozzle and the receiving portion at least in the part of the
region where the liquid metal target is formed,

the nozzle ejects the liquid metal target to the receiving portion linearly, and
wherein a wave surface of the liquid metal target forms a concavo-convex shape corresponding to the concavo-convex shape of
the discharge port of the nozzle, and the liquid metal is liquid lithium.

US Pat. No. 9,702,018

QUENCH TANK AND LIQUID METAL LOOP

MITSUBISHI HEAVY INDUSTRI...

1. A quench tank which is disposed in a circulation path of a liquid metal loop
the quench tank comprising:
a tank body having a cylindrical shape, a hole at a lower side surface, and a tube at an upper side surface, the tank body
configured to receive liquid metal from the tube and discharge liquid metal at the hole; and

a cylindrical body configured to receive the liquid metal at the hole, the cylindrical body being inclined so that a distal
end of the cylindrical body is lower than a proximal end of the cylindrical body and configured to form a flow of the liquid
metal in an axial direction of the cylindrical body, the cylindrical body being attached to the tank body at the proximal
end and the distal end being oriented away from the tank body,

wherein separating plates are disposed inside the cylindrical body, the separating plates being arranged such that in a cross-sectional
view of the cylindrical body from the axial direction of the cylindrical body, the separating plates are inclined relative
to a vertical plane indicated by a vertical line in the cross-sectional view,

a plurality of first rectification plates extending toward a center portion of the tank body are radially provided on an inner
surface of the tank body at a lower portion of the tank body with a space at the center portion of the tank body, and

a second rectification plate is provided at the hole.
US Pat. No. 9,255,278

POLYNUCLEOTIDE ENCODING PPAT DERIVED FROM JATROPHA AND USE THEREOF

SUMITOMO ELECTRIC INDUSTR...

1. A vector comprising:
(a) a cDNA comprising the polynucleotide represented by SEQ ID NO: 2 or
(b) a polynucleotide encoding a phosphopantetheine adenylyltransferase (PPAT) polypeptide having a homology of 95% or higher
with the amino acid sequence of SEQ ID NO: 1, wherein said polynucleotide is operably linked to a heterologous regulatory
element.

US Pat. No. 9,496,622

PHOTONIC-CRYSTAL SLAB ABSORBER AND HIGH-FREQUENCY CIRCUIT AND ELECTRONIC COMPONENTS, AND TRANSMITTER, RECEIVER AND PROXIMITY WIRELESS COMMUNICATION SYSTEM

ROHM CO., LTD., Kyoto (J...

1. A photonic-crystal slab absorber comprising:
a two dimensional photonic crystal slab composed of semiconducting materials; and
a plurality of lattice points periodically arranged in the two dimensional photonic crystal slab, each lattice point for forming
resonant-state which can capture an electromagnetic wave incident from an outside by resonating an electromagnetic wave in
a band edge of a photonic band structure of the two dimensional photonic crystal slab in the plane of the two dimensional
photonic crystal slab, wherein

the two dimensional photonic crystal slab is doped with impurities and can absorb the captured electromagnetic wave in the
band edge resonant frequency, wherein

an amount of impurities doping level of a surface portion of the two dimensional photonic crystal slab is higher than an amount
of the impurities doping level of a portion of the two dimensional photonic crystal slab other than the surface portion.

US Pat. No. 9,191,080

RECEPTION DEVICE, TRANSMISSION DEVICE, RECEPTION METHOD, TRANSMISSION METHOD, PROGRAM, AND RADIO COMMUNICATION SYSTEM

SHARP KABUSHIKI KAISHA, ...

1. A reception device comprising:
a reception unit for receiving signals transmitted by assigning respectively a plurality of different frequency signal groups,
which are generated based on a same bit sequence, to a plurality of layers;

an MIMO demultiplexing unit for implementing MIMO demultiplexing of the signals, received by the reception unit, into the
frequency signal groups corresponding respectively to the plural layers;

a de-interleaving unit for applying different de-interleaves, for each of the plural layers, to the frequency signal groups
resulting from the MIMO demultiplexing implemented by the MIMO demultiplexing unit and corresponding respectively to the plural
layers;

a demodulation unit for demodulating, for each of the plural layers, the frequency signal groups having been subjected to
the de-interleaves by the de-interleaving unit; and

a combining unit for merging individual items of information based on the demodulated frequency signal groups, the items of
information corresponding respectively to the plural layers.

US Pat. No. 9,067,200

METHOD FOR PRODUCING SUBSTITUTED FLUORINE-CONTAINING OLEFIN

DAIKIN INDUSTRIES, LTD., ...

1. A method for producing a fluoroolefin substituted with a substituted or unsubstituted aryl or alkyl,
the method comprising reacting a fluoroolefin selected from the group consisting of tetrafluoroethylene, hexafluoropropylene
and trifluoroethylene with an organic magnesium compound in the presence of a fluorophilic compound and a catalyst comprising
nickel or palladium,

to produce the fluoroolefin substituted with the substituted or unsubstituted aryl or alkyl.
US Pat. No. 9,242,911

PREPARATION METHOD FOR FLUORINE-CONTAINING OLEFINS HAVING ORGANIC-GROUP SUBSTITUENTS

OSAKA UNIVERSITY, Osaka ...

1. A method for preparing a fluorine-containing olefin substituted with an organic group or groups,
the method comprising a step of reacting a fluorine-containing olefin, which is an olefin substituted with one or more fluorine
atoms and at least one of the fluorine atoms is bonded to an sp2 hybridized carbon atom, with an organic boron compound in the presence of an organic transition metal catalyst containing
at least one transition metal selected from the group consisting of nickel, palladium, platinum, rhodium, ruthenium, and cobalt,

to replace at least one fluorine atom bonded to the sp2 hybridized carbon atom with a group represented by R,

wherein R is an optionally substituted aryl, an optionally substituted heteroaryl that is bonded via a carbon atom thereof,
an optionally substituted cycloalkyl, an optionally substituted alkyl, an optionally substituted alkenyl, or an optionally
substituted alkynyl.

US Pat. No. 9,174,221

METHOD AND APPARATUS FOR SEPARATION OF MIXTURE

OSAKA UNIVERSITY, Osaka ...

1. A mixture separation method for applying a magnetic field having a magnetic field gradient to a mixture containing a plurality
of types of particles formed of mutually different materials in a supporting liquid to separate the plurality of types of
particles by type or separate a specific type of particles from the mixture,
wherein the magnetic field gradient has a vertical component and a horizontal component,
the plurality of types of particles travel horizontally in the supporting liquid, and are arranged at mutually different heights
depending on a density and a volume susceptibility of the material forming each type of particles, by applying the magnetic
field to the mixture in the supporting liquid,

the supporting liquid is an organic solvent solution obtained by dissolving one or more types of paramagnetic compounds in
an organic solvent, and

the plurality of types of particles include particles of an inorganic salt, an organic acid salt, an inorganic oxide or a
macromolecular compound.

US Pat. No. 9,308,536

METHOD AND APPARATUS FOR SEPARATION OF MIXTURE

OSAKA UNIVERSITY, Osaka ...

1. A mixture separating method for separating, by type, a mixture containing at least two types of particles made of different
substances using the magneto-Archimedes effect, or for separating particles of a specific type from the mixture using the
magneto-Archimedes effect,
particles of one type of the at least two types of particles being made of a paramagnetic or diamagnetic substance, and the
particles of the one type having a density and a volume susceptibility different from a density and a volume susceptibility
of particles of another type of the at least two types of particles,

the method comprising:
(i) a step of applying a magnetic field whose magnetic field gradient has a vertical component and a horizontal component
to a supporting liquid stored in a separating tank;

(ii) a step of placing the mixture into the supporting liquid to which the magnetic field has been applied, and guiding the
particles of the one type such that the particles of the one type are positioned in the supporting liquid at a predetermined
height from a bottom face of the separating tank; and

(iii) a step of collecting the particles of the one type positioned at the predetermined height,
wherein the guiding the particles of the one type in step (ii) comprises a step of putting the particles of the one type in
a floating state due to the magneto-Archimedes effect, and applying a horizontal force to the particles of the one type, the
horizontal force resulting from the magnetic field and being proportional to a difference in volume susceptibility between
the particles of the one type and the supporting liquid, thereby causing the particles of the one type to horizontally travel
while sinking to the predetermined height, with the floating state due to the magneto-Archimedes effect being maintained,
and

the particles of the another type are positioned at a position vertically different from that of the particles of the one
type, between the bottom face of the separating tank and a liquid surface of the supporting liquid.

US Pat. No. 9,230,694

METHOD OF DETERMINING NUCLEAR FUSION IRRADIATION COORDINATES, DEVICE FOR DETERMINING NUCLEAR FUSION IRRADIATION COORDINATES, AND NUCLEAR FUSION DEVICE

OSAKA UNIVERSITY, Suita-...

1. A device for determining nuclear fusion irradiation coordinates as an information processing device that calculates irradiation
coordinates of energy lines when the energy lines are irradiated onto nuclear fusion fuel, comprising:
an initial arrangement means that arranges a predetermined number of electric charges at the predetermined number of initial
coordinates on a spherical surface centered at the nuclear fusion fuel set by using random numbers;

a coordinate analysis means that analyzes coordinates ri (i=1, . . . NB, NB: number of irradiation coordinates) of the predetermined number of electric charges arranged at the initial
coordinates in time series based on coulomb forces acting among the predetermined number of electric charges by constraining
the coordinates onto the spherical surface;

a potential evaluation means that determines a timing at which potential energies of the predetermined number of electric
charges were stabilized based on the coordinates analyzed by the coordinate analysis means; and

an irradiation coordinate deriving means that derives coordinates of the predetermined number of electric charges at the timing
determined by the potential evaluation means as irradiation coordinates of the energy lines when nuclear fusion fuel is arranged
at the center of the spherical surface,

wherein the potential evaluation means calculates a sum EP of potential energies of the predetermined number of electric charges according to the following equation (2),


calculates a temporal change of the sum EP, which is a difference between a sum EP previously calculated based on the coordinates ri and a sum EP calculated at this time based on coordinates ri, and determines whether the temporal change is not more than a predetermined value.

US Pat. No. 9,440,855

HIGH PURITY CARBON NANOTUBE, PROCESS FOR PREPARING THE SAME AND TRANSPARENT CONDUCTIVE FILM USING THE SAME

Osaka University, Osaka ...

1. A process for producing single-walled carbon nanotubes by chemical vapor deposition (CVD), comprising:
providing growth nuclei comprising particles of a nonmetallic material containing 500 ppm or lower of metallic impurities
including metals and compounds of the metals;

introducing a growth gas for growth of carbon nanotubes in an initial growth stage into a furnace, and
thereafter introducing a growth gas for stationary growth of carbon nanotubes in a stationary growth stage,
wherein the growth gas for growth of carbon nanotubes in the initial growth stage is different from the growth gas for stationary
growth of carbon nanotubes in the stationary growth stage in composition and/or partial pressure.

US Pat. No. 9,236,488

THIN FILM TRANSISTOR AND METHOD FOR PRODUCING SAME

CHUBU UNIVERSITY EDUCATIO...

1. A thin film transistor, comprising:
a silicon substrate having a main surface formed with a stripe-like or grid-like concave-convex configuration;
a channel layer formed of a plurality of carbon nanowall thin films which are disposed on a plurality of protruding portions
along a length direction of the protruding portion of the concave-convex shape, and respectively grows in a normal direction
of the silicon substrate;

a source electrode at least contacting a first side surface of each of the plurality of carbon nanowall thin films which is
in parallel to a thickness direction of the carbon nanowall thin film;

a drain electrode disposed so as to be opposed to the source electrode in an in-plane direction of the carbon nanowall thin
film, and at least contacting a second side surface of each of the plurality of carbon nanowall thin films which is opposite
to the first side surface;

a gate electrode; and
an insulating film disposed between the plurality of carbon nanowall thin films and the gate electrode.

US Pat. No. 9,236,162

TRANSPARENT CONDUCTIVE INK AND TRANSPARENT CONDUCTIVE PATTERN FORMING METHOD

OSAKA UNIVERSITY, Osaka ...

1. A transparent conductive ink for pattern printing comprising at least either one of metal nanowires and metal nanotubes,
and a dispersion medium which contains a shape-holding material and a viscosity adjustment solvent,
the shape-holding material containing an organic compound and having a viscosity at 25° C. of 1.0×103 to 2.0×106 mPa·s,

the organic compound having an alkyl group comprising a bridged carbon cyclic structure, and a hydroxyl group, and having
a molecular weight in the range of 150 to 500,

the viscosity adjustment solvent being at least one of alcohol, ether, and an aliphatic hydrocarbon solvent,
the content of the metal nanowires or the metal nanotubes relative to the total mass of the transparent conductive ink being
0.01 to 10% by mass,

the content of the shape-holding material relative to the total mass of the dispersion medium being 10 to 90% by mass, and
the metal nanowires and the metal nanotubes having an average diameter size of 1 to 500 nm, an average aspect ratio of more
than 5, and an average major axis length of 1 to 100 ?m.

US Pat. No. 9,370,782

METHOD AND APPARATUS FOR SEPARATION OF MIXTURE

OSAKA UNIVERSITY, Osaka ...

1. A mixture separation method for separating, by type, a mixture containing first particles and second particles which are
different in type, or separating a specific type of particles from the mixture, using a separation tube having an inverted-conical
or pyramidal shape or a substantially inverted-conical or pyramidal shape, the first particles and the second particles being
respectively made of substances having different magnetic susceptibilities, the method comprising:
causing a fluid to flow upward through the separation tube;
introducing the mixture into the separation tube and holding the first particles and the second particles in the separation
tube through which the fluid is flowing;

applying a gradient magnetic field to the first particles and the second particles that are held in the separation tube; and
moving the second particles in the separation tube to outside the separation tube by changing the flow of the fluid in the
separation tube in a state where the gradient magnetic field is being applied,

wherein a magnetic field gradient of the gradient magnetic field has a vertical component, and
wherein the first particles are brought together at substantially the same height in the separation tube when the gradient
magnetic field is applied.

US Pat. No. 9,504,417

ORAL CAVITY SENSOR

THE UNIVERSITY OF TOKYO, ...

1. An oral cavity sensor comprising
a sensor main body configured to be attached in an oral cavity of a subject and configured to measure external force applied
from a tongue in the oral cavity,

wherein the sensor main body includes an elastic body elastically deformable by the external force applied from the tongue,
a sensor element embedded in the elastic body and configured, on the basis of a displacement state of the elastic body, to
measure external force components in three axis directions orthogonal to each other, said sensor element including a first
sensor section deformable in a first direction, a second sensor section deformable in a second direction orthogonal to the
first direction, and a third sensor section deformable in a third direction orthogonal to the first direction and the second
direction, the first sensor section and the second sensor section each being provided with a cantilever-shape and the third
sensor section being provided with a cantilever section having a both-end supported beam, wherein each of the first sensor
section, the second sensor section, and the third sensor section includes a piezoresistive layer configured to detect, as
a resistance value change, a displacement state thereof, and each of resistance value changes generated in the piezoresistive
layers due to movements of the tongue is outputted as an output signal a wiring body and

a coating film made of a para-xylene based polymer and covering the elastic body.
US Pat. No. 9,266,899

METHOD FOR PRODUCING EPOXY COMPOUND

OSAKA UNIVERSITY, Osaka ...

1. A method for producing an epoxy compound with a low chlorine content by reacting a compound having a carbon-carbon double
bond with hydrogen peroxide in the coexistence of the compound having a carbon-carbon double bond, the hydrogen peroxide solution,
a powdered solid catalyst support and a powdered solid catalyst all together, the solid catalyst comprising isopolyacids produced
from (a) tungstic acid or a salt thereof and (b) a quaternary ammonium salt compound and/or pyridinium salt compound, selected
from chlorine free compounds, wherein the chlorine content of the epoxy compound is 100 ppm by mass or less.
US Pat. No. 9,138,465

PHARMACEUTICAL COMPOSITION FOR TREATING LYSOSOMAL STORAGE DISEASE

OSAKA UNIVERSITY, Osaka ...

1. A process for producing a pharmaceutical composition for treating mucolipidosis type II or type III, comprising a group
of purified lysosomal enzymes as an active ingredient, the process comprising obtaining the group of lysosomal enzymes by
performing the following steps:
adding to a cell one or more reagents selected from the group consisting of amphiphilic amines, lysosome-tropic amines, ionophores,
and V-ATPase inhibitors, followed by culturing;

collecting a culture supernatant; and
purifying the obtained culture supernatant,
wherein the group of purified lysosomal enzymes comprises at least ?-mannosidase, ?-fucosidase, ?-galactosidase, ?-glucosidase,
?-galactosidase, ?-glucosidase, ?-hexosaminidase, ?-glucuronidase, galactocerebrosidase, and cathepsin, and wherein the purified
lysosomal enzymes are not recombinant enzymes.

US Pat. No. 9,297,811

PRODUCTION OF ENTERITIS EVOKING CAUSAL FACTOR BY HIGHLY PATHOGENIC ORAL BACTERIA AND HIGH SENSITIVITY DETECTION METHOD THEREFOR

National University Corpo...

1. A method of detecting an oral bacterium for diagnosing whether inflammatory bowel disease is aggravated in a subject, comprising
contacting saliva or plaque obtained from the subject with a collagen binding protein (CBP)-detecting reagent,
performing an assay to detect CBP of oral bacteria in the saliva or plaque obtained from the subject,
confirming the presence in the saliva or plaque obtained from the subject of an oral bacterium that aggravates inflammatory
bowel disease when the CBP is detected, and

diagnosing that inflammatory bowel disease is aggravated in the subject when the oral bacterium that aggravates inflammatory
bowel disease is present in the saliva or plaque obtained from the subject.

US Pat. No. 9,217,192

SEMICONDUCTOR DEVICE AND BONDING MATERIAL FOR SEMICONDUCTOR DEVICE

OSAKA UNIVERSITY, Suita-...

1. A semiconductor device, comprising: a substrate; and a semiconductor member stacked on the substrate, wherein the semiconductor
member and the substrate are bonded together by means of a semiconductor device bonding material of which main component is
zinc, a coating layer to prevent diffusion of the semiconductor device bonding material is provided on at least one of the
surface of the substrate and the surface of the semiconductor member, and the coating layer is configured such that a barrier
layer composed of nitride, carbide, or carbonitride and a protective layer composed of a noble metal are stacked.

US Pat. No. 9,157,004

COMPOSITION FOR FORMING COPPER PATTERN AND METHOD FOR FORMING COPPER PATTERN

NOF CORPORATION, Tokyo (...

1. A composition for copper patterning, comprising:
Component A: a copper ?-ketocarboxylate compound represented by the formula (1):

wherein R1 and R2 each independently stands for a hydrogen atom or a C1-C6 straight- or C3-C6 branched-hydrocarbon group,
or R1 and R2 are linked with a C2-C4 hydrocarbon group; and based on 1 mol of Component A,

Component B: an amine compound having a boiling point of not higher than 250° C. in an amount of 0.1 to 500 mol; and
at least one of:
Component C-1: an organic acid having pKa of not more than 4 in an amount of 0.01 to 20 mol, and
Component C-2: an organic copper compound composed of copper and an organic acid having pKa of not more than 4 in an amount
of 0.01 to 100 mol.

US Pat. No. 9,575,389

LIGHT MODULATOR AND EXPOSURE HEAD

Screen Holdings Co., Ltd....

1. A light modulator which modulates light propagating in a propagation direction, comprising:
a first electro-optic crystal substrate having a first periodic polarization reversal structure including a plurality of first
and second polarization sections alternately arranged in a first period along a first arrangement direction orthogonal to
the propagation direction to allow the light to propagate through the first periodic polarization reversal structure, directions
of polarization developed in each first polarization section and each second polarization section in response to electric
fields being opposite to each other;

a second electro-optic crystal substrate having a second periodic polarization reversal structure including a plurality of
third and fourth polarization sections alternately arranged in a second period along a second arrangement direction orthogonal
to the propagation direction to allow outgoing light from the first electro-optic crystal substrate to propagate through the
second periodic polarization reversal structure, directions of polarization developed in each third polarization section and
each fourth polarization section in response to electric fields being opposite to each other; and

a driver that applies a voltage upon the first electro-optic crystal substrate and the second electro-optic crystal substrate
to create diffraction gratings inside the first periodic polarization reversal structure and the second periodic polarization
reversal structure, thereby modulating the light,

wherein the first period and the second period are different from each other.

US Pat. No. 9,541,508

INSPECTING DEVICE AND INSPECTING METHOD

SCREEN HOLDINGS CO., LTD....

1. An inspecting device comprising:
an irradiation part for irradiating an inspecting target with each of pump light and probe light having the same pulse period;
a detection part for detecting an electromagnetic wave generated from said inspecting target by irradiating said inspecting
target with said probe light;

a measurement delay part for delaying the time of arrival of said probe light at said inspecting target relatively to said
pump light; and

a reverse bias voltage applying part for applying a reverse bias voltage to said inspecting target, wherein
said irradiation part includes a scanning mechanism to scan with said probe light a scanned and observed area which is larger
than an irradiated area being irradiated with said pump light in said inspecting target, an area which is not irradiated with
said pump light being also observed in addition to the irradiated area, and

a diameter of a spot of said probe light is smaller than a diameter of a spot of said pump light, and
the reverse bias voltage applied by said reverse bias voltage applying part is variable.
US Pat. No. 9,308,519

ADSORBENT FOR ORGANIC FLUORO-COMPOUND COMPRISING CYCLODEXTRIN-SUPPORTED POLYMER

DAIKIN INDUSTRIES, LTD., ...

1. An adsorbent for an organic fluoro-compound, wherein cyclodextrin is supported on the surface of a water-insoluble polymer,
wherein the water-insoluble polymer comprises polystyrene particles,
wherein the polystyrene particles and the cyclodextrin are chemically bonded via a divalent linking group —X— in which
X is N, O, S, O(CH2)nO, with n being 1 to 6, or

X is O(CH2CH2O)n, with n being 2 to 6, and

the hyphen “-” is a single bond; and
wherein the organic fluoro-compound is selected from the group consisting of fluoroalkane carboxylic acids (R—COOH), fluoroalkane
sulfonic acids (R—SO3H), fluoroalkyl alcohols (R—(CH2)nOH, with n being 1 to 6, and a mixture thereof, in which R is selected from the group consisting of CF3(CF2)n, with n 0 to 11; HCF2(CF2)n with n being 0 to 11; CF3(CF2)nO[CF(CF3)CF2O]mCF(CF3), with n being 0 to 5 and m being 0 to 5; and (CF3)2CF(CF2)n, with n being 0 to 10.

US Pat. No. 9,212,169

BENZIMIDAZOLE DERIVATIVE AND USE THEREOF

HYOGO COLLEGE OF MEDICINE...

1. A compound represented by the formula (I):

wherein
R1 is

a C1-6 alkyl group optionally substituted by a halogen atom,

a C6-10 aryl group optionally substituted by one or more substituents selected from the group consisting of a halogen atom and a C1-6 alkyl group, or

a halogen atom;
R2 is a C1-6 alkyl group or a C6-10 aryl group;

R3 is

a C7-11 aralkyl group optionally substituted by one or more substituents selected from the group consisting of a halogen atom, a C1-6 alkyl group optionally substituted by a halogen atom, a C6-10 aryl group and a C1-6 alkoxy group,

a C6-10 aryl group, or

a C1-6 alkyl group optionally substituted by one or more substituents selected from the group consisting of a C6-10 aryl group, a C1-6 alkoxy-carbonyl group, a carboxyl group, and a C3-6 cycloalkyl group; and

R4 is a hydrogen atom;
or a pharmaceutically acceptable salt thereof.
US Pat. No. 9,688,733

METHOD FOR TREATING SPINAL CORD INJURY USING HMGB1 FRAGMENT

GENOMIX CO., LTD., Osaka...

1. A method for treating injury or the spinal cord, comprising the step of administering a peptide that has an activity of
stimulating the migration of mesenchymal stem cells, and comprises an amino acid sequence selected from the group consisting
of SEQ ID NO: 3, SEQ ID NO: 4, and SEQ ID NO: 5.
US Pat. No. 9,623,078

METHOD FOR TREATING CARDIAC INFARCTION USING HMGB1 FRAGMENT

GENOMIX CO., LTD., Osaka...

1. A method for treating myocardial infarction in a subject, wherein said method comprises administering, to a subject in
need of such treatment, an HMGB1 fragment peptide consisting of the amino acid sequence of SEQ ID NO: 3.

US Pat. No. 9,233,449

POLISHING METHOD, POLISHING APPARATUS AND GAN WAFER

OSAKA UNIVERSITY, Osaka ...

1. A polishing method comprising:
preparing a Ga element-containing compound semiconductor substrate, whose surface has raised portions and recessed portions;
immersing the substrate in a processing solution comprising a buffer solution containing Ga ions, a concentration of the Ga
ions being in a range of 10 ppm to 100 ppm, and the buffer solution having a pH in a range of 6 to 8;

irradiating the surface of the substrate with light or applying a bias potential to the substrate, or applying a bias potential
to the substrate while irradiating the surface of the substrate with light, thereby forming Ga oxide on the surface of the
substrate in the processing solution; and

rotating the substrate and a polishing tool with respect to each other to selectively polish and remove the Ga oxide formed
on the raised portions of the surface of the substrate,

wherein the processing solution contains oxygen dissolved therein, and
wherein the processing solution does not comprise nitrogen dissolved from any Ga element-containing compound semiconductor
substrate.

US Pat. No. 9,651,607

PHOTO DEVICE INSPECTION APPARATUS AND PHOTO DEVICE INSPECTION METHOD

SCREEN HOLDINGS CO., LTD....

1. A photo device inspection apparatus for inspecting a photo device, comprising:
an irradiation part configured to irradiate said photo device with light from a light source;
an electromagnetic wave detection part configured to detect an electromagnetic wave radiated from said photo device in response
to irradiation with said light, wherein

said irradiation part comprises a scanning mechanism configured to scan an inspection target area of said photo device with
said light;

a current detection part configured to detect a current generated by said photo device in response to irradiation with said
light;

a current intensity distribution image generation part coupled to the current detection part and configured to generate a
current intensity distribution image that indicates an intensity distribution of said current generated in said inspection
target area,

said current intensity distribution image is an image generated based on a current value detected by said current detection
part:

an electromagnetic wave intensity distribution image generation part configured to generate an electromagnetic wave intensity
distribution image that indicates an intensity distribution of said electromagnetic wave generated in said inspection target
area; and

an image composition part configured to composite said current intensity distribution image and said electromagnetic wave
intensity distribution image.

US Pat. No. 9,212,188

METHOD FOR PRODUCING ALICYCLIC DIEPOXY COMPOUND

OSAKA UNIVERSITY, Suita-...

1. A method for producing an alicyclic diepoxy compound represented by formula (1) below by reacting an alicyclic olefin compound
represented by formula (2) below with hydrogen peroxide in the coexistence of the alicyclic olefin compound represented by
formula (2) below, a hydrogen peroxide solution, a powdered solid catalyst support and a powdered solid catalyst all together:

wherein R1 and R12 are each hydrogen, halogen, an alkyl group optionally having halogen or an alkoxy group optionally having
halogen or an alkoxy group as a substituent, and

wherein the powdered solid catalyst is selected from the group consisting of isopolytungstic acids containing cetyltrimethylammonium
as a cation and isopolytungstic acids containing (NH4)[H2W12O42] and an organic cation selected from the group consisting of tetrabutylammonium, butylammonium, benzyltrimethylammonium,
and cetylpyridinium.

US Pat. No. 9,194,874

TEST METHOD FOR MALE FERTILITY BY DETECTING A MUTATION IN THE PGAM4 GENE

TOPPAN PRINTING CO., LTD....

1. A test method for fertility of a human male subject, comprising:
contacting a biological sample obtained from a human male subject with an oligonucleotide comprising 15 or more consecutive
nucleotides of SEQ ID NO: 3, wherein the 15 or more consecutive nucleotides includes position 101 of SEQ ID NO: 3, with the
exception that position 101 of SEQ ID NO: 3 is a cytosine nucleotide in place of a guanine nucleotide;

detecting the presence or absence of hybridization of the oligonucleotide to target nucleic acids in the biological sample
to thereby detect the presence of a cytosine or guanine nucleotide at the 75th nucleotide position of the translation region
of the human PGAM4 gene; and

assessing fertility of the human male subject based on the presence or absence of a guanine to cytosine mutation at the 75th
nucleotide position of the translation region of the human PGAM4 gene, wherein when a guanine nucleotide is detected at the
75th nucleotide position of the human PGAM4 gene, then it is determined that the human male subject is highly likely to have
no problem in fertility, and when a guanine nucleotide is not detected at the 75th nucleotide position of the human PGAM4
gene, then it is determined that the human male subject has an increased likelihood of being infertile,

wherein the translation initiation codon, adenine, in the coding region of the human PGAM4 gene is set to be the 1st nucleotide.
US Pat. No. 9,393,224

PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR CARDIOVASCULAR COMPLICATIONS OF DIABETES

OSAKA UNIVERSITY, Osaka ...

1. A method for treating a cardiovascular complication of diabetes, the method comprising a step of administering a compound
for inhibiting neutral lipid accumulation in cardiovascular tissue or cells to a diabetic patient or a diabetic non-human
mammal with a cardiovascular complication of diabetes, the compound being a medium-chain triglyceride, the medium-chain triglyceride
being a simple or mixed acid triglyceride composed of a saturated fatty acid, the saturated fatty acid being capric acid alone
or caprylic acid and capric acid,
wherein the method excludes administering fish oil.

US Pat. No. 9,095,600

PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR CARDIAC INFARCTION

OSAKA UNIVERSITY, Suita-...

1. A method for treatment of myocardial ischemia-reperfusion injury without an increase in collateral blood flow, the method
comprising administering an active agent consisting of a lipid membrane structure retaining adenosine to a subject in need
thereof,
wherein said administering is intravenously,
wherein the lipid membrane structure contains (i) a phospholipid, (ii) a cholesterol and/or a cholestanol, and (iii) a polyethylene
glycol derivative selected from the group consisting of

N-{carbonyl-methoxypolyethylene glycol-2000}-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine,
N-{carbonyl-methoxypolyethylene glycol-5000}-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine,
N-{carbonyl-methoxy-polyethylene glycol-750}-1,2-distearoyl-sn-glycero-3-phosphoethanolamine,
N-{carbonyl-methoxy-polyethylene glycol-2000}-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, and
N-{carbonyl-methoxy-polyethylene glycol-5000}-1,2-distearoyl-sn-glycero-3-phosphoethanolamine as components thereof,
wherein the lipid membrane structure is a liposome,
wherein the ratio by mole of adenosine to the total lipid content of the phospholipid and cholesterol contained in the lipid
membrane structure is ranges from 0.01 to 2,

wherein adenosine is administered in an amount effective to reduce the incidence of myocardial ischemia-reperfusion injury,
said amount ranging from 2.25 mg/kg to 36 mg/kg, and

wherein a therapeutic benefit is observed after a single dosage.

US Pat. No. 9,561,511

METHOD AND APPARATUS FOR SEPARATION OF MIXTURE

UBE INDUSTRIES, LTD., Ya...

1. A mixture separation method for applying a gradient magnetic field to a paramagnetic supporting liquid containing a mixture
of first particles and second particles of different types to separate the mixture by particle type,
wherein a magnetic susceptibility of the first particles is lower than a magnetic susceptibility of the supporting liquid,
and

a magnetic susceptibility of the second particles is higher than the magnetic susceptibility of the supporting liquid,
the mixture separation method comprising:
applying the gradient magnetic field to the supporting liquid in a separation tank provided with a magnetic filter and stirring
the supporting liquid;

applying the gradient magnetic field so that the first particles float in the supporting liquid or at a liquid surface thereof
by the magneto-Archimedes effect, at least over the magnetic filter; and

catching the second particles in the supporting liquid with the magnetic filter excited by the gradient magnetic field.

US Pat. No. 9,325,149

MULTI-BEAM COMBINING APPARATUS

Mitsubishi Heavy Industri...

1. A multi-beam combining apparatus comprising:
a phase shifting section configured to generate a plurality of phase-shifted laser beams by shifting a phase of each of a
plurality of laser beams;

a superposing section configured to generate a plurality of superposed laser beams by superposing a reference laser beam and
each of the plurality of phase-shifted laser beams;

an observing section configured to generate interference pattern data of a spatial interference pattern when observing each
of the plurality of superposed laser beams; and

a phase control section configured to carry out a feedback control of the phase shift in said phase shifting section based
on the interference pattern data obtained from each of the plurality of superposed laser beams, and set each of the plurality
of phase-shifted laser beams to a desired state,

wherein said observing section comprises a plurality of observing units disposed respectively to observe the plurality of
superposed laser beams,

wherein each of said plurality of observing units comprises a plurality of sensors configured to observe an intensity of a
corresponding one of the plurality of superposed laser beams in a plurality of observation positions, and

wherein the interference pattern data contains the intensity observed in each of the plurality of observation positions.

US Pat. No. 9,377,398

LIQUID INSPECTING METHOD AND LIQUID INSPECTING DEVICE

OSAKA UNIVERSITY, Suita-...

1. A liquid inspection method for checking whether an explosive, a raw material for explosive, or an illicit drug is contained
in a liquid with which an optically transparent container for a drink is filled, comprising:
a near-infrared irradiation step in which a substantially whole portion of the liquid is irradiated by an irradiation unit
with near-infrared light having wavelengths of 650 to 1000 nm from outside the container;

a near-infrared light reception step in which the near-infrared light passed through the liquid or the near-infrared light
scattered by the liquid is received by a light reception unit; and

an absorption spectrum analysis step in which an absorption spectrum of the received near-infrared light is analyzed,
wherein whether an explosive, a raw material for explosive, or an illicit material is contained in a liquid with which the
container is filled is checked by analyzing the absorption spectrum,

the liquid is a drink which may contain the explosive, a raw material for an explosive or an illicit drug filled in the optically
transparent container,

the irradiation unit and the light reception unit are integrated,
the near-infrared light is emitted by the irradiation unit into the container from a surface of the container to conduct the
near-infrared irradiation step, and the near-infrared light scattered by the liquid is received through the surface of the
container by the light reception unit to conduct the near-infrared light reception step.

US Pat. No. 9,373,474

ION SOURCE, AND MASS SPECTROSCOPE PROVIDED WITH SAME

Osaka University, Osaka ...

1. An ion source for a time-of-flight mass spectrometer comprising:
an electron gun which emits an electron beam;
a first electrode, a second electrode, and a third electrode that are configured to ionize a sample to obtain ions and accelerate
the ions in a pulsed manner to obtain pulsed ions;

wherein the electron beam is introduced into an ion generation area between the first electrode and the third electrode;
wherein the first electrode, the third electrode and the second electrode are arranged in this order in a travelling direction
of the ions;

wherein the first electrode is configured to push the ions;
wherein the third and the second electrodes are configured to pull the ions;
wherein the first electrode has a shape with a depression curved in the opposite direction to the travelling direction of
the ions such that curved isopotential planes are formed at the time of ion acceleration and the ions can be pulled out while
the ions existing on the curved isopotential planes are caused to temporally converge by giving temporal isometry to respective
acceleration paths;

wherein the third electrode has a shape with a depression curved in the opposite direction to the travelling direction of
the ions, the depression curves are configured to make the pulsed ions exiting a hole through the second electrode temporally
and spatially converge;

wherein a voltage difference between the first and the third electrodes is 1750V to 2100V and a voltage difference between
the third and the second electrode is 3600V to 3700V.

US Pat. No. 9,295,489

GUIDE TUBE SYSTEM FOR FORMING PNEUMOPERITONEUM AND PROVIDING ROUTE FOR ACCESSING BODY CAVITY

Osaka University, Osaka ...

1. A guide tube for forming a pneumoperitoneum comprising a flexible tube having an inner cavity,
wherein the guide tube has an outer diameter that allows the guide tube to be inserted into a puncture needle having a size
of 14 G to 18 G,

a distal end of the guide tube is closed, and the distal end is provided with a wire that can be held by holding forceps provided
in an endoscope and the wire has a length that allows the wire to be pulled into the endoscope,

a proximal end of the flexible tube is provided with a connecting portion to an insufflation apparatus, and
the flexible tube includes a side hole region having at least one side hole that can establish communication between the inner
cavity of the flexible tube and outside the flexible tube in a case where the inner cavity is pressurized through insufflation,

an insufflation source attached to the connecting portion and providing carbon dioxide to the at least one side hole,
wherein the wire is located distal to the side hole region of the flexible tube,
a proximal end of the wire is attached to the closed distal end of the flexible tube and a distal end of the wire projects
distally beyond the distal end of the flexible tube,

the wire is formed thinner than the flexible tube, and
the length of the wire is 0.5 m to 5 m, and the length of the flexible tube is 0.3 m to 1.5 m.

US Pat. No. 9,150,762

MATERIAL SELF-ASSEMBLY METHOD AND SELECTIVE ADHESION METHOD BASED ON MOLECULAR RECOGNITION

Osaka University, Suita ...

1. An assembly comprising one or more host bodies formed from a macromolecule having one or more host groups in the side chains,
and one or more guest bodies formed from a macromolecule having one or more guest groups in the side chains, wherein the one
or more host bodies and the one or more guest bodies are in contact with each other and form the assembly, wherein the one
or more host bodies are a gel of a crosslinked polymer having repeating units represented by the following general formulae
(1) and (2), and the one or more guest bodies are a gel of a crosslinked polymer having repeating units represented by the
following general formulae (1) and (3):

wherein X represents a hydroxyl group, C(O)NH2, or C(O)OH, and n is 1 to 200,000,


wherein CD represents ?-cyclodextrin, ?-cyclodextrin, or ?-cyclodextrin, and m is 1 to 200,000,

wherein A represents O or NH, R represents an optionally-substituted alkyl group, or an optionally-substituted aryl group,
and l is 1 to 200,000,

the host groups corresponding to the group CD in general formula (2), and the guest groups corresponding to the group R in
general formula (3).

US Pat. No. 9,127,280

OLIGONUCLEOTIDE, AND THERAPEUTIC AGENT FOR DYSLIPIDEMIA CONTAINING OLIGONUCLEOTIDE AS ACTIVE INGREDIENT

Osaka University, Osaka ...

1. An oligonucleotide comprising a sugar-modified nucleoside,
the sugar-modified nucleoside having a bridging structure between 4?-position and 2?-position, and
the oligonucleotide being capable of binding to human PCSK9 gene,
wherein the bridging structure is represented by —CO—NR1—, —CH2—CO—NR1—, —(CH2)2—CO—NR1—, —CO—NR1—X—, or —CH2—CO—NR1—X—, wherein

R1 is a hydrogen atom;

a C1-7 alkyl group that may form a branch or ring;

a C2-7 alkenyl group that may form a branch or ring;

a C3-12 aryl group that may have any one or more substituents selected from an ? group consisting of a hydroxyl group, C1-6 linear alkyl group, C1-6 linear alkoxy group, mercapto group, C1-6 linear alkylthio group, amino group, C1-6 linear alkylamino group, and halogen atom, and that may contain a hetero atom; or

an aralkyl group having a C3-12 aryl portion that may have any one or more substituents selected from the ? group and that may contain a hetero atom; and

X is an oxygen atom, sulfur atom, amino group, or methylene group.

US Pat. No. 9,081,176

OBSERVATION SYSTEM AND OBSERVATION METHOD

OSAKA UNIVERSITY, Suita-...

1. An observation system for observing a to-be-observed specimen on the basis of coming light coming from the to-be-observed
specimen, comprising:
a first conversion unit configured to convert the coming light to a first converted light ray with a first pupil function;
a second conversion unit configured to convert the coming light to a second converted light ray with a second pupil function
different from the first pupil function; and
an image information generation unit configured to generate image information on the to-be-observed specimen on the basis
of the first converted light ray and the second converted light ray,
wherein each of the first pupil function and the second pupil function is a function in two-dimensional donut shape with an
inner ring and an outer ring,

the first conversion section and the second conversion section allow regions inside the respective inner rings to function
as shielded regions and allow regions surrounded by the respective inner rings and the respective outer rings to function
as non-shielded regions of the first pupil function and the second pupil function, respectively, and

the first pupil function and second pupil function change at least one of a phase, a transmittance, and a reflectivity of
the respective regions surrounded by the respective inner rings and the respective outer rings.

US Pat. No. 9,400,279

DETECTION/MEASUREMENT OF MALARIA INFECTION DISEASE UTILIZING NATURAL IMMUNITY BY HEMOZOIN INDUCTION, SCREENING OF PREVENTATIVE OR THERAPEUTIC MEDICINE FOR MALARIA INFECTION DISEASE, AND REGULATION OF NATURAL IMMUNITY INDUCTION

Osaka University, Osaka ...

1. A method for stimulating innate immunity through the TLR9-MyD88-dependent pathway, comprising administering a composition
comprising a TLR9 agonist to an animal in need thereof that expresses MyD88 and TLR9, wherein the TLR9 agonist is hemozoin
or ?-hematin, and wherein immunostimulant of the composition consists of hemozoin or ?-hematin.

US Pat. No. 9,597,436

ADVANCED HEART FAILURE TREATMENT MATERIAL AS MYOCARDIAL/CARDIOVASCULAR REGENERATION DEVICE

Osaka University, Suita-...

1. An advanced heart failure treatment material comprising a pharmaceutical agent, an agent holding the pharmaceutical agent,
and a myocardial support device,
wherein the pharmaceutical agent is an internal regeneration factor production inducing agent comprising a prostaglandin I2 agonist indicated by the following general Formula (I) or a salt thereof:


wherein,
R1 is a hydrogen atom or a C1-4 alkyl group,

R2 is (i) a hydrogen atom, (ii) a C1-8 alkyl group that may be branched or form a ring, (iii) a phenyl group or a C4-7 cycloalkyl
group, (iv) a 4-7-membered single ring containing one nitrogen atom, (v) a C1-4 alkyl group substituted by a benzene ring
or a C4-7 cycloalkyl group, or (vi) a C1-4 alkyl group substituted by a 4-7-membered single ring containing one nitrogen atom,

R3 is (i) a C1-8 alkyl group that may be branched or form a ring, (ii) a phenyl group or a C4-7 cycloalkyl group, (iii) a 4-7-membered
single ring containing one nitrogen atom, (iv) a C1-4 alkyl group substituted by a benzene ring or a C4-7 cycloalkyl group,
or (v) a C1-4 alkyl group substituted by a 4-7-membered single ring containing one nitrogen atom, and

e is an integer of 3-5, f is an integer of 1-3, p is an integer of 1-4, q is 1 or 2, and r is an integer of 1-3,
provided that in a case where,

is a group indicated by (iii) or (iv), —(CH2)p— and ?CH—(CH2)r— are bound to a or b on a ring, and a ring in R2 and R3 may be substituted by one to three C1-4 alkyl groups, C1-4 alkoxy groups, halogen atoms, nitro groups, or trihalomethyl groups,

wherein the agent holding the pharmaceutical agent comprises at least one high-molecular weight compound selected from the
group consisting of fibrin, gelatin, collagen, and hyaluronic acid.

US Pat. No. 9,371,301

PRENYLARENE COMPOUND AND USE THEREOF

Osaka University, Osaka ...

1. A compound represented by the general formula (C):

wherein R101 represents a substituted or unsubstituted furyl group or a substituted or unsubstituted thienyl group,

R102 , R103 , R104 and R105 may be the same or different, and each represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms,
or a haloalkyl group having 1 to 3 carbon atoms, and

R106 represents a hydrogen atom, or a saturated or unsaturated hydrocarbon group which is a straight or branched chain having 1
to 12 carbon atoms, but excluded is the case where when R101 is a 3-furyl group, and R102, R103, R104 and R105 are all methyl groups, R106 is not a methyl group, a 4-methyl-3-pentenyl group or a 4,8-dimethyl-3,7-nonadienyl group; or

a pharmaceutically acceptable salt thereof.

US Pat. No. 9,333,529

DEVICE FOR PRODUCING PARTICLE FILM AND METHOD FOR PRODUCING PARTICLE FILM

OSAKA UNIVERSITY, Osaka ...

1. An apparatus for producing a particle film by sweeping a meniscus area in a particle dispersion liquid filling a space
between a first substrate and a second substrate facing the first substrate and by forming the particle film on the first
substrate while evaporating a solvent in the meniscus area, the apparatus comprising:
particle concentration measuring capacitance meter for measuring a concentration of particles in the meniscus area, wherein
the particle concentration measuring capacitance meter includes a sensor probe that is used to measure capacitance in the
meniscus area in a noncontact manner and determine particle concentration from the capacitance;

a device configured to adjust the concentration of particles in the meniscus area by applying a direct-current electric field
between the first substrate and the second substrate in accordance with the particle concentration measured with the particle
concentration measuring capacitance meter, wherein the device adjusts the concentration of particles in the meniscus area
by controlling a speed at which the first substrate changes from one position to another, wherein the following formula is
utilized to determine coverage of the particles in the meniscus area: (c=k×?/(v(1??)), where c is the coverage, k is a constant,
? is the concentration of particles in the dispersion liquid (% by volume), and v is the speed at which the first substrate
moves (?m/s), and

a capacitive displacement meter provided with a sensor probe for measuring a degree of bending of the first substrate from
a value of capacitance formed between the sensor probe and the first substrate, wherein the particle concentration measuring
capacitance meter determines the particle concentration in accordance with the degree of bending measured by the capacitive
displacement meter provided with a sensor probe, in addition to the capacitance in the meniscus area.

US Pat. No. 9,233,143

MEDICINAL AGENT FOR PREVENTING EXACERBATION OF MALIGNANT TUMOR, COMPRISING COMBINATION OF NATRIURETIC PEPTIDE RECEPTOR GC-A AND GC-B AGONISTS

National Cerebral and Car...

1. A method for treating a malignant tumor or for suppressing or preventing the exacerbation thereof, comprising administering
an effective amount of an atrial natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 1and an effective
amount of a c-type natriuretic peptide consisting of the amino acid sequence of SEQ ID NO: 7 in combination, wherein the effective
amount of atrial natriuretic peptide is 0.01 ?g kg?1 min?1 or more and 0.2 ?g kg?1 min?1 or less and the effective amount of c-type natriuretic peptide is 0.01 ?g kg?1 min?1 or more and 1.0 ?g kg?1 min?1 or less, and wherein the effective amount is administered continuously for at least three days.
US Pat. No. 9,187,443

METHOD FOR PRODUCING EPOXY COMPOUND

OSAKA UNIVERSITY, Suita-...

1. A method for producing an epoxy compound by reacting a compound having a carbon-carbon double bond with hydrogen peroxide,
comprising carrying out repeatedly or continuously the following steps (1), (2) and (3):
step (1) of reacting a compound having a carbon-carbon double bond with hydrogen peroxide in the coexistence of (a) the compound
having a compound having a carbon-carbon double bond, (b) a hydrogen peroxide solution, (c) a powdered solid catalyst support
and (d) a powdered solid catalyst and optionally further (e) an organic solvent to produce an epoxy compound;

step (2) of separating the epoxy compound that is the reaction product from the reaction mixture produced in step 1; and
step (3) of adding (d) the powdered solid catalyst and also adding (a) the compound having a carbon-carbon double bond, (b)
the hydrogen peroxide solution, (c) the powdered solid catalyst support and optionally further (e) the organic solvent to
the mixture of the powdered solid catalyst support and powdered solid catalyst after separating the reaction product in step
(2)

wherein the powdered solid catalyst is selected from the group consisting of isopolytungstic acids containing cetyltrimethylammonium
as a cation and isopolytungstic acids containing (NH4)[H7W12O42] and an organic cation selected from the group consisting of tetrabutylammonium, butylammonium, benzyltrimethylammonium,
and cetylpyridinium.

US Pat. No. 9,534,042

INFLUENZA VIRUS-NEUTRALIZING ANTIBODY AND SCREENING METHOD THEREFOR

Fujita Health University,...

1. An isolated antibody comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:15
and a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:26, wherein the antibody binds
influenza virus HA.
US Pat. No. 9,446,120

DNA VACCINE

Osaka University, Suita ...

1. A method for the treatment or improvement of hypertension in a mammal, comprising inducing production of a neutralizing
antibody to angiotensin II (AngII) by administering an effective amount of an expression vector encoding a chimeric Hepatitis
B virus core antigen polypeptide inserted with an amino acid sequence comprising a specific epitope of AngII to the mammal,
wherein the amino acid sequence comprising the specific epitope is inserted between the amino acid residues 80 and 81 of the
hepatitis B virus core antigen polypeptide.

US Pat. No. 9,337,922

WAVEFORM RECONSTRUCTION DEVICE, WAVEFORM RECONSTRUCTION SYSTEM, AND WAVEFORM RECONSTRUCTION METHOD

OSAKA UNIVERSITY, Osaka ...

11. A waveform reconstruction method for reconstructing a time waveform of an input optical signal, the waveform reconstruction
method comprising:
(a) obtaining information indicating a power spectrum of the input optical signal;
(b) obtaining, for each of intensities of the input optical signal, a measured power spectrum which is obtained by measuring
an output optical signal that is the input optical signal output after having propagated through an optical transmission medium
having a nonlinear optical effect;

(c) simulating, for each of the intensities of the input optical signal where the input optical signal is assumed to have
a given phase spectrum, propagation of the input optical signal through the optical transmission medium, to calculate a power
spectrum of the output optical signal;

(d) performing iterations of simulating the propagation to make a search for a phase spectrum of the input optical signal
while changing the given phase spectrum to reduce differences between the calculated power spectra and the measured power
spectra of the input optical signal having the intensities; and

(e) performing frequency-time transform on the phase spectrum found through the search and the power spectrum indicated in
the obtained information, to reconstruct the time waveform of the input optical signal,

wherein in step (d), in the iterations of simulating the propagation, the given phase spectrum is changed in accordance with
a constraint on the phase spectrum that is to be satisfied when the input optical signal is assumed to be a resultant signal
that has propagated through a medium having only a dispersion effect out of the nonlinear optical effect and the dispersion
effect and the propagation is simulated, and subsequently the given phase spectrum is changed independently of the constraint
and the propagation is simulated.

US Pat. No. 9,287,016

REFLECTIVE SURFACE SHAPE CONTROLLABLE MIRROR DEVICE, AND METHOD FOR MANUFACTURING REFLECTIVE SURFACE SHAPE CONTROLLABLE MIRROR

JTEC CORPORATION, Kobe-s...

1. A reflective surface shape controllable mirror device for reflecting an x-ray beam in the soft and hard x-ray regions to
thereby change a wavefront of the x-ray beam into an ideal wavefront, the reflective surface shape controllable mirror device
comprising:
A reflective surface shape controllable mirror; the mirror including
A substrate having a front surface and a back surface,
A band-shaped x-ray reflective surface formed on a central portion of the front surface of the substrate with desired accurate
precision,

Reference planes formed along both sides of the x-ray reflective surface with desired accurate precision,
Wherein shapes of the x-ray reflective surface and the reference planes are measured, and wherein the shapes and relative
shape difference therebetween are calculated to be obtained as initial shape data,

A plurality of piezoelectric elements attached to the front surface or the back surface of the substrate in lines along lateral
sides of the reference planes so as to be arranged in the longitudinal direction of the x-ray reflective surface on both side
portions of the substrate so as to be symmetric with respect to the x-ray reflective surface, and

A plurality of-piezoelectric elements attached to an opposite surface of the substrate in such manner that the piezoelectric
elements are arranged in lines so as to be symmetric with respect to the x-ray reflective surface, and

A multichannel control system for applying a voltage to each of the piezoelectric elements.
US Pat. No. 9,182,216

METHOD FOR OBSERVING PROTEIN CRYSTAL

OSAKA UNIVERSITY, Osaka ...

1. A method for observing a good quality protein crystal, wherein said protein crystal is produced by a gel crystallization
method and said protein crystal is observed by optical coherence tomography (OCT) and measuring light emitting from an ultra-wideband
light source and an interfering light generated from a scattering light of the emitting light.

US Pat. No. 9,078,585

MUSCLE SYNERGY ANALYSIS METHOD, MUSCLE SYNERGY ANALYZER, AND MUSCLE SYNERGY INTERFACE

Osaka University, Osaka ...

1. A muscle synergy analysis method, comprising:
detecting in a time-divisional manner, at each one muscle of an antagonistic muscle pair group of a first human using a first
electrode attached to a skin surface overlying said one muscle, a first myoelectric signal generated at said one muscle during
a predetermined motion;

storing said myolelectric signal into a RAM as reference data;
detecting in said time-divisional manner, at each one muscle of an antagonistic muscle pair group of a compared human using
a second electrode attached to a skin surface overlying said one muscle of said compared human, a second myoelectric signal
generated at said one muscle of said compared human during a comparison predetermined motion, wherein the compared human is
one of either a same person or a different person than the first human;

storing said second myolelectric signal into said RAM as comparison data;
evaluating by a microcomputer a difference in an antagonistic muscle ratio between a principal component of a first antagonistic
muscle ratio calculated from said reference data and a principal component of a second antagonistic muscle ratio calculated
from said comparison data; and

displaying said evaluated, antagonistic muscle ratio difference at a display monitor; and
wherein said evaluating comprises:
reading the reference data from said RAM,
calculating said first antagonistic muscle ratio as a time series of first antagonistic muscle ratio values from a time series
of said reference data corresponding to said first myolectric signal of said each one muscle of said antagonistic muscle pair
of said first human,

conducting multivariate analysis on said time series of reference data in which a corresponding first antagonistic muscle
ratio value from said times series of said first antagonistic muscle ratio values is a variable at a corresponding time of
the time-series of said reference data, and calculating the principal component of said first antagonistic muscle ratio to
include at least a first principal component having high contribution to a first correlation;

reading the comparison data from said RAM,
calculating said second antagonistic muscle ratio as a time series of second antagonistic ratio values from a time series
of said comparison data corresponding to said second myolectric signal of said each one muscle of said antagonistic muscle
pair of said compared human, and

conducting multivariate analysis on said time series of comparison data in which a corresponding second antagonistic muscle
ratio value from said times series of said second antagonistic muscle ratio values is a variable at a corresponding time of
the time-series of said comparison data, and calculating the principal component of said second antagonistic muscle ratio
to include at least a second principal component having high contribution to a second correlation.

US Pat. No. 9,447,426

POLYNUCLEOTIDE ENCODING NF-YB DERIVED FROM JATROPHA AND USE THEREOF

OSAKA UNIVERSITY, Osaka ...

1. A vector comprising a heterologous nucleotide sequence and a polynucleotide
with at least 99% identity to SEQ ID NO: 1, wherein expression of the polynucleotide enhances stress resistance in Jatropha compared to wild-type Jatropha.

US Pat. No. 9,379,341

ORGANIC THIN FILM TRANSISTOR AND METHOD FOR PRODUCING SAME

Osaka University, Osaka ...

1. An organic thin film transistor comprising:
an insulating substrate;
gate electrodes provided on the substrate;
a gate insulating film formed so as to cover the gate electrodes;
an organic semiconductor film formed on the gate insulating film; and
a source electrode and a drain electrode that are disposed so as to come into contact with the organic semiconductor film,
wherein the gate electrodes comprises
a main gate electrode that is disposed in a region opposed to a channel region in the organic semiconductor film between the
source electrode and the drain electrode, and

a pair of auxiliary gate electrodes that are disposed in respective regions opposed to the source electrode and the drain
electrode and at first and second sides of the main gate electrode,

the main gate electrode and the auxiliary gate electrodes are formed in different layers of an insulating film from each other,
the insulating film is interposed between the main gate electrode and the auxiliary gate electrodes so as to electrically
separate the main gate electrode and the auxiliary gate electrodes from each other, and

the gate insulating film comprises the insulating film.
US Pat. No. 9,284,326

METHOD FOR PRODUCING EPOXY COMPOUND

OSAKA UNIVERSITY, Suita-...

1. A method for producing an epoxy compound by reacting a compound having a carbon-carbon double bond with hydrogen peroxide
in the coexistence of (a) a compound having a carbon-carbon double bond, (b) a hydrogen peroxide solution, (c) a powdered
solid catalyst support and (d) a powdered solid catalyst and optionally (e) an organic solvent wherein the total mass of (c)
and (d) is 100 percent by mass or less on the basis of the total mass of (a), (b) and (e), wherein the solid catalyst is an
isopolyacid containing tungsten and/or a salt thereof and the method comprises preparing a slurry by mixing the components
(a) to (e) and allowing them to contact one another in the slurry.

US Pat. No. 9,153,789

TRANSISTOR WITH SOURCE/DRAIN ELECTRODES ON PEDESTALS AND ORGANIC SEMICONDUCTOR ON SOURCE/DRAIN ELECTRODES, AND METHOD FOR MANUFACTURING SAME

OSAKA UNIVERSITY, Osaka ...

1. An organic transistor comprising:
an insulating substrate;
a pair of insulating pedestals arranged spaced apart from each other on the insulating substrate and forming respectively
raised flat surfaces;

a source electrode provided on the raised flat surface formed on one of the pedestals;
a drain electrode provided on the raised flat surface formed on the other pedestal;
a gate electrode provided on the insulating substrate between the pair of pedestals; and
an organic semiconductor layer arranged in contact with an upper surface of the source electrode and an upper surface of the
drain electrode,

wherein the gate electrode and a lower surface of the organic semiconductor layer oppose each other vertically across a gap
region, and

side surfaces of the pedestals facing the gap region are shaped such that the side surfaces increase in distances in a horizontal
direction from the gate electrode with decreasing height from upper side edges toward lower side edges of the side surfaces.

US Pat. No. 9,117,643

ALKALI METAL INTRODUCTION APPARATUS AND ALKALI METAL INTRODUCTION METHOD

OSAKA UNIVERSITY, Osaka ...

1. An alkali metal introduction apparatus for use in an experiment in which an alkali metal vapor is used, comprising:
a hollow chamber;
a vacuum creating section for evacuating the chamber;
an exposing section for causing, in the chamber, an alkali metal encapsulated in an encapsulation container to be exposed
out of the encapsulation container by deforming the encapsulation container;

a container introduction room configured to allow the encapsulation container to be introduced therein, the container introduction
room being provided inside the chamber; and

a container moving section for moving the encapsulation container between an exposure position which is a position different
from a position where the container introduction room is provided and at which the alkali metal is to be exposed out of the
encapsulation container thus deformed and an introduction position where the encapsulation container thus deformed is to be
introduced into the container introduction room.

US Pat. No. 9,089,550

COMBINED ISLET TRANSPLANTATION USING PANCREATIC ISLETS AND ADIPOSE TISSUE DERIVED STEM CELLS

OSAKA UNIVERSITY, Osaka ...

1. A pharmaceutical composition comprising a composite consisting essentially of adipose tissue-derived stem cells adhered
onto a pancreatic islet and a pharmaceutically acceptable carrier, wherein 90% or more of the surface of the pancreatic islet
is covered with the adipose tissue-derived stem cells.

US Pat. No. 9,594,258

CONTACT LENS HAVING MYOPIA PROGRESSION SUPPRESSION CAPABILITY, AND CONTACT LENS SET HAVING MYOPIA PROGRESSION SUPPRESSION CAPABILITY

OSAKA UNIVERSITY, Suita-...

1. A contact lens having a myopia progression suppression capability whose optical part includes a refractive correction power
set in a central region for correcting myopia and myopic astigmatism, wherein:
a positive additional power as compared to a power in the central region is set in a peripheral region of the optical part
to correct a hyperopic focal error in order to suppress progression of myopia and myopic astigmatism beyond the refractive
correction power set in the central region;

a positioning member that specifies a circumferential position of the lens under a worn condition is provided;
a lens optical axis of the optical part is set offset from a lens geometric center to align with a line of sight of a human
eye under the worn condition produced by the positioning member, and

a positive spherical aberration is given to the optical part due to the additional power set in the peripheral region of the
optical part while the lens optical axis of the optical part is set offset from a lens geometric center to align with the
line of sight of the human eye under the worn condition due to the positioning member as well as an offset structure of the
lens optical axis of the optical part so that a depth of focus increases without causing any reduction of subjective QOV associated
with an increase in asymmetrical high-order aberration such as coma aberration.

US Pat. No. 9,262,591

ELECTRONIC STATE COMPUTING METHOD, ELECTRONIC STATE COMPUTING DEVICE, AND RECORDING MEDIUM

Osaka University, Osaka ...

1. A method for computing an exact solution for an electronic state of a crystal structure by performing a first principle
calculation using a computer, the method comprising:
evaluating a deviation from the exact solution of the electronic state of the crystal structure to be obtained to an approximate
value obtained by local density approximation or generalized gradient approximation using an energy functional determined
by a density serving as an order parameter deciding the electronic state, space derivatives of the density and fluctuations
of physical quantities; and

computing the exact solution, in a space being composed of a set including a plurality of groups as elements, each group being
comprised of a model Hamiltonian decided when the energy functional is introduced and the order parameter deciding the electronic
state, by

generating the elements, based on whether a distance between the elements meets a given convergence, comprising
computing a distance between the elements using the order parameter with respect to the elements included in the set,
if the distance between the groups meets the given convergence then generating the exact solution of the electron state of
the crystal structure based on the elements and terminating, else

computing the approximate value regarding a functional derivative of the energy functional,
estimating an asymptotic direction toward the exact solution from approximate values of functional derivatives of the energy
functional,

incrementing the order parameter of the respective model Hamiltonians of the groups, based at least in part on the estimated
asymptotic direction, and

repeating the generating the elements.

US Pat. No. 9,057,105

METHOD FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISM IN NUCLEIC ACID

FURUKAWA ELECTRIC ADVANCE...

1. A method for detecting a single nucleotide polymorphism in nucleic acids, characterized in that the method comprises:
mixing (A):
i) a nucleic acid probe comprising a nucleotide sequence complementarily hybridizable to an evaluation subject nucleic acid
comprising at least one single nucleotide polymorphism, and tagged with a nucleotide sequence of a hairpin structure having
a cytosine bulge or thymine bulge at a 5?-terminal thereof,

wherein a guanine residue is introduced at a position immediately adjoining 5? or 3?-terminal side of the cytosine bulge or
thymine bulge, and wherein a 2,7-diaminonaphthyridine derivative compound is immobilized to the cytosine bulge or thymine
bulge; or

ii) a nucleic acid probe comprising a nucleotide sequence complementarily hybridizable to an antisense strand of an evaluation
subject nucleic acid comprising at least one single nucleotide polymorphism, and tagged with a nucleotide sequence of a hairpin
structure having a cytosine bulge or thymine bulge at a 5?-terminal thereof,

wherein a guanine residue is introduced at a position immediately adjoining 5? or 3?-terminal side of the cytosine bulge or
thymine bulge, and wherein a 2,7-diaminonaphthyridine derivative compound is immobilized to the cytosine bulge or thymine
bulge; and

(B) the evaluation subject nucleic acids; and
detecting a signal ascribed to the 2,7-diaminonaphthyridine derivative compound due to the disappearance of the above cytosine
bulge or thymine bulge when said nucleic acid probe and said evaluation subject nucleic acids are hybridized, thereby evaluating
said single nucleotide polymorphism.

US Pat. No. 9,482,692

MAGNETIC FIELD VALUE MEASURING DEVICE AND METHOD FOR MEASURING MAGNETIC FIELD VALUE

AKITA UNIVERSITY, Akita-...

1. A magnetic field measuring device which detects a direct-current magnetic field originating from a specimen, the device
comprising:
a vibrational probe unit comprising a probe, the probe comprising one or more material whose intensity of magnetization is
proportionate to an external magnetic field;

a mechanical vibration source mechanically oscillating the probe;
a vibration detector detecting a mechanical vibration frequency of the probe and a mechanical vibration amplitude of the probe;
an alternating-current magnetic field generator applying an alternating-current magnetic field to the probe, the alternating
magnetic field having a frequency different from the mechanical vibration frequency of the probe and having a nonzero gradient
in a direction of the mechanical vibration of the probe;

a direct-current external magnetic field generator applying to the probe a direct-current external magnetic field in the direction
of the mechanical vibration of the probe;

a frequency modulation detector detecting frequency modulation occurring in the mechanical vibration of the probe from the
mechanical vibration frequency detected by the vibration detector;

a direct-current external magnetic field adjuster adjusting intensity of the direct-current external magnetic field in the
direction of the mechanical vibration of the probe applied by the direct-current external magnetic field generator to the
probe; and

a direct-current magnetic field determination unit determining a value of the direct-current magnetic field in the direction
of the mechanical vibration of the probe originating from the specimen, based on an output value of the direct-current external
magnetic field generator when intensity of the frequency modulation takes a minimum value or on an expected output value of
the direct-current external magnetic field generator when the intensity of the frequency modulation is expected to take a
minimum value.

US Pat. No. 9,045,556

THERAPEUTIC AGENT FOR CANCER

NEC Corporation, Tokyo (...

1. A therapeutic agent for malignant tumor or a prophylactic agent for malignant tumor metastasis or recurrence, comprising
WT1 or a peptide comprising a portion of the amino acid sequence thereof, wherein the peptide consists of the amino acid sequence
shown in SEQ ID NO:2 or SEQ ID NO:4, a pertussis vaccine, and a carrier, the pertussis vaccine is a whole cell pertussis vaccine,
and the whole cell pertussis vaccine is an adjuvant,
wherein the peptide is present in the agent in an amount of 0.1 to 5 mg and the vaccine is present in an amount of 1×108 to 1×109 cells of the whole cell pertussis vaccine.

US Pat. No. 10,031,416

REAGENT FOR ENHANCING GENERATION OF CHEMICAL SPECIES

Toyo Gosei Co., Ltd., Ic...

1. A composition, comprising:a resin being able to react with a first chemical species to cause a deprotection reaction of the resin; and
a precursor being a photoacid generator; and
a reagent that generates a product that enhances a generation of the first chemical species from the precursor by a first reaction of the precursor, the reagent being represented by formula (I),
where:R1 is a pi-conjugated system, which may be substituted by at least one electron donating group;
R2 is selected from the group consisting of a hydrogen atom, a phenyl group, which may be substituted by at least one electron donating group, an alkyl group, an alkenyl group, an alkynyl group, and an alkyl group containing a cyclic or polycyclic moiety;
each of R3 and R4 is selected from the group consisting of an alkyl group, an alkenyl group, an aralkyl group, an alkynyl group, and an alkyl group containing a cyclic or poly cyclic moiety;
R3 is not connected to R4; and
Y is an oxygen atom or sulfur atom.
US Pat. No. 9,737,636

METHOD FOR PRODUCING LAMINATE OF SHEET-SHAPED CELL CULTURE AND FIBRIN GEL

TERUMO KABUSHIKI KAISHA, ...

1. A method for producing a laminate of a fibrin gel and a sheet-shaped cell culture, comprising:
dripping a liquid containing fibrinogen onto an upper surface of a sheet-shaped cell culture;
spraying a liquid containing thrombin onto the surface after dripping the liquid containing fibrinogen onto the surface; and
forming a fibrin gel layer on the surface by a reaction between the fibrinogen and the thrombin.

US Pat. No. 9,187,510

LIGHT-EMITTING ORGANIC PLATINUM COMPLEX, LIGHT-EMITTING MATERIAL CONTAINING THIS COMPLEX AND FUNCTIONAL DEVICE

OSAKA UNIVERSITY, Osaka ...

1. A light-emitting organic platinum complex represented by any one of structural formulae below:

wherein for structural formula (1):
Z is —CH2(CH2OCH2)mCH2—;

m represents 3 or 4;
A is a benzene ring; and
R is hydrogen, a halogen, a methyl group, an ethyl group, a methoxy group, an ethoxy group, a trifluoromethoxy group, a difluoromethoxy
group, a hydroxy group, a hydroxyethyl group, a dimethylamino group, a diethylamino group, a nitro group, an acetoxy group,
a phenyl group, an alkyl phenyl oxy group having 7 to 13 carbon atoms, an alkynyl phenyl group having 8 to 13 carbon atoms,
or an alkenyl phenyl group having 8 to 13 carbon atoms;

wherein structural formula (2a) or (2b) is either:
Z is —(CH2)n—;

n is an integer of 7 to 14;
A is a benzene ring; and
R is hydrogen, a halogen, a methyl group, an ethyl group, a methoxy group, an ethoxy group, a trifluoromethoxy group, a difluoromethoxy
group, a hydroxy group, a hydroxyethyl group, a dimethylamino group, a diethylamino group, a nitro group, an acetoxy group,
a phenyl group, an alkyl phenyl oxy group having 7 to 13 carbon atoms, an alkynyl phenyl group having 8 to 13 carbon atoms,
or an alkenyl phenyl group having 8 to 13 carbon atoms;

or
Z is —CH2(CH2OCH2)mCH2—;

m represents 3 or 4;
A is a benzene ring; and
R is hydrogen, a halogen, a methyl group, an ethyl group, a methoxy group, an ethoxy group, a trifluoromethoxy group, a difluoromethoxy
group, a hydroxy group, a hydroxyethyl group, a dimethylamino group, a diethylamino group, a nitro group, an acetoxy group,
a phenyl group, an alkyl phenyl oxy group having 7 to 13 carbon atoms, an alkynyl phenyl group having 8 to 13 carbon atoms,
or an alkenyl phenyl group having 8 to 13 carbon atoms.

US Pat. No. 9,056,094

ADJUVANT

NIPPON ZENYAKU KOGYO CO.,...

1. A method of inducing a Th1 immunoreaction and an increase in production of IgG2 or IgG2a antibody specific to an isolated
allergen or an isolated antigen in an animal, the method comprising administering to the animal, intranasally or subcutaneously,
a vaccine composition comprising the isolated allergen or the isolated antigen and a vaccine adjuvant composition that comprises
isolated or synthetic hemozoin or beta-hematin and Alum adjuvant.

US Pat. No. 10,073,349

CHEMICALLY AMPLIFIED RESIST MATERIAL, PATTERN-FORMING METHOD, COMPOUND, AND PRODUCTION METHOD OF COMPOUND

OSAKA UNIVERSITY, Suita-...

1. A pattern-forming method comprising:patternwise exposing a predetermined region of a resist material film made from a photosensitive resin composition comprising a chemically amplified resist material to a first radioactive ray that is ionizing radiation or nonionizing radiation having a wavelength of no greater than 400 nm;
floodwise exposing the resist material film patternwise exposed, to a second radioactive ray that is nonionizing radiation having a wavelength greater than the wavelength of the nonionizing radiation for the patternwise exposing and greater than 200 nm;
baking the resist material film floodwise exposed; and
developing the resist material film baked with a developer solution to form a resist pattern,
the chemically amplified resist material comprising:
a base component that is capable of being made soluble or insoluble in the developer solution by an action of an acid; and
a generative component that is capable of generating a radiation-sensitive sensitizer and an acid upon an exposure,
wherein the generative component comprises:
a radiation-sensitive acid-and-sensitizer generating agent and a radiation-sensitive sensitizer generating agent;
the radiation-sensitive sensitizer generating agent and a radiation-sensitive acid generating agent; or
the radiation-sensitive acid-and-sensitizer generating agent, the radiation-sensitive sensitizer generating agent and the radiation-sensitive acid generating agent,
wherein
the radiation-sensitive acid-and-sensitizer generating agent generates, upon an exposure to the first radioactive ray, an acid, and a radiation-sensitive sensitizer absorbing the second radioactive ray, and substantially does not generate the acid and the radiation-sensitive sensitizer upon an exposure to the second radioactive ray in light-unexposed regions that are not exposed to the first radioactive ray in the patternwise exposing;
the radiation-sensitive sensitizer generating agent generates, upon the exposure to the first radioactive ray, a radiation-sensitive sensitizer absorbing the second radioactive ray, and substantially does not generate the radiation-sensitive sensitizer upon the exposure to the second radioactive ray in light-unexposed regions that are not exposed to the first radioactive ray in the patternwise exposing; and
the radiation-sensitive acid generating agent generates an acid upon the exposure to the first radioactive ray, and substantially does not generate the acid upon the exposure to the second radioactive ray in light-unexposed regions that are not exposed to the first radioactive ray in the patternwise exposing,
the radiation-sensitive sensitizer generating agent comprises at least one compound represented by formula (A):

wherein, in the formula (A),
Ra1 and Ra2 each independently represent a monovalent organic group having 1 to 20 carbon atoms, or Ra1 and Ra2 taken together represent a ring structure having 4 to 20 ring atoms together with O—C—O to which Ra1 and Ra2 bond;
Ra3 and Ra4 each independently represent a monovalent organic group having 1 to 20 carbon atoms, —OH, —SH, —NH2, —PH2, a halogen atom or a nitro group;
m and n are each independently an integer of 0 to 4, wherein a sum of m and n is no less than 1, wherein in a case where m is no less than 2, a plurality of Ra3s are identical or different, and at least two of the plurality of Ra3s optionally taken together represent a ring structure having 4 to 20 ring atoms together with the carbon chain to which the at least two of the plurality of Ra3s bond, and wherein in a case where n is no less than 2, a plurality of Ra4s are identical or different, and at least two of the plurality of Ra4s optionally taken together represent a ring structure having 4 to 20 ring atoms together with the carbon chain to which the at least two of the plurality of Ra4s bond; and
X represents a single bond, an oxygen atom, a sulfur atom, —CRa5Ra6— or —NRa7—,
wherein Ra5, Ra6 and Ra7 each independently represent a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms, wherein in a case where m is no less than 1, one or a plurality of Ra3(s) and at least one of Ra5 and Ra6 optionally taken together represent a ring structure having 4 to 20 ring atoms together with the carbon chain to which the one or a plurality of Ra3(s) and the at least one of Ra5 and Ra6 bond, wherein in a case where n is no less than 1, one or a plurality of Ra4 and at least one of Ra5 and Ra6 optionally taken together represent a ring structure having 4 to 20 ring atoms together with the carbon chain to which the one or a plurality of Ra4 and the at least one of Ra5 and Ra6 bond, wherein in a case where m is no less than 1, one or a plurality of Ra3(s) and Ra7 optionally taken together represent an aliphatic heterocyclic structure having 4 to 20 ring atoms together with the atom chain to which the one or a plurality of Ra3(s) and Ra7 bond, and wherein in a case where n is no less than 1, one or a plurality of Ra4(s) and Ra7 optionally taken together represent an aliphatic heterocyclic structure having 4 to 20 ring atoms together with the atom chain to which the one or a plurality of Ra4(s) and Ra7 bond, and
the at least one compound represented by formula (A) is a recrystallized substance.
US Pat. No. 9,624,353

NON-IONIC SURFACTANT COMPOSITION AND FLUOROPOLYMER AQUEOUS DISPERSION

DAIKIN INDUSTRIES, LTD., ...

1. A nonionic surfactant composition comprising:
a nonionic surfactant that comprises a molecule having a C10-C22 alkyl group and/or alkenyl group as a hydrophobic group, a polyoxyalkylene chain as a hydrophilic group, no aromatic ring,
no C9-C14 alkyl group derived from an alcohol that is produced from a higher olefin derived from a mixture of propylene and butene through
an oxo process, and no C13 alkyl group derived from an alcohol that is produced from a higher olefin derived from a propylene tetramer through an oxo
process,

wherein the nonionic surfactant has a hydrodynamic radius of 5.0 to 8.0 nm at 40° C. in an aqueous solution in which a nonionic
surfactant concentration is 0.1 kg/L in the nonionic surfactant composition, the radius being measured by a dynamic light
scattering method

wherein the nonionic surfactant comprises a nonionic surfactant represented by the formula (1):
R1O(CH2CH2O)n1H
wherein R1 is a C13 linear or branched alkyl group (except a C13 alkyl group derived from an alcohol that is produced from a higher olefin derived from a mixture of propylene and butene through
an oxo process, and a C13 alkyl group derived from an alcohol that is produced from a higher olefin derived from a propylene tetramer through an oxo
process), and n1 is an integer of 5 to 15, and
a nonionic surfactant represented by the formula (2):
R2O(CH2CH(CH3)O)m(CH2CH2O)n2H
wherein R2 is a C10-C16 linear or branched alkyl group (except a C10-C14 alkyl group derived from an alcohol that is produced from a higher olefin derived from a mixture of propylene and butene through
an oxo process, and a C13 alkyl group derived from an alcohol that is produced from a higher olefin derived from a propylene tetramer through an oxo
process), n2 is an integer of 5 to 20, and m is an integer of 1 to 6, and
wherein a molar ratio (1)/(2) of the nonionic surfactant represented by the formula (1) to the nonionic surfactant represented
by the formula (2) is (99 to 60)/(1 to 40).

US Pat. No. 9,309,164

METHOD FOR PURIFICATION OF SUBSTANCES CONTAMINATED WITH ORGANIC CHEMICALS

OSAKA UNIVERSITY, Suita-...

1. A method for purifying an aromatic compound-containing contaminated substance comprising:
a first step of irradiating the aromatic compound-containing contaminated substance with light in the presence of (i) at least
one water-soluble alkali metal compound and/or at least one water-soluble alkaline-earth metal compound selected from the
group consisting of calcium compounds, magnesium compounds, potassium compound, and sodium compounds, and (ii) at least one
transition metal ionic compound selected from the group consisting of cobalt compounds, manganese compounds, nickel compounds,
copper compounds and zinc compounds, whereby the aromatic compound is polymerized,

wherein the transition metal ionic compound is a metal compound in which a transition metal becomes ions in an aqueous solution;
and

a second step of collecting the polymerized aromatic compound that is generated in the first step.

US Pat. No. 10,074,818

TRANSISTOR

TOPPAN FORMS CO., LTD., ...

1. A transistor comprising a gate electrode, an insulating layer, a semiconductor layer, a source electrode, and a drain electrode on a substrate,wherein the gate electrode comprises silver 2-methyl acetoacetate,
wherein a mobility of the carrier in a linear region is greater than or equal to 4.7 cm2/Vs, and the mobility of the carrier in a saturated region is greater than or equal to 4.0 cm2/Vs,
wherein a current ON/OFF ratio (log A) of the transistor is 2.0 or more, and 6.0 or less,
wherein the semiconductor layer is an organic semiconductor,
when a threshold voltage of the transistor is 0 V or more and 10 V or less, the transistor is operated on a gate voltage with the ?30 V to the threshold voltage, and
when a threshold voltage of the transistor is ?2 V or more and lower than 0 V, the transistor is operated on a gate voltage with the ?20 V to the threshold voltage.
US Pat. No. 9,260,516

METHOD FOR PROMOTING MUSCLE REGENERATION BY ADMINISTERING AN ANTIBODY TO THE IL-6 RECEPTOR

Osaka University, Osaka ...

1. A method for promoting muscle regeneration in a subject affected with muscle atrophy, which comprises the steps of:
selecting a subject having muscle atrophy caused by an absence of gravitational loading or disuse muscle atrophy;
subsequently administering to the subject an effective amount of an IL-6 inhibitor antibody that binds to an IL-6 receptor,
inhibits IL-6 from binding to the IL-6 receptor, and further inhibits the IL-6 signaling pathway; and

subsequently re-loading the subject's atrophied muscles for at least 7 days.

US Pat. No. 9,169,281

MONONUCLEAR METAL COMPLEX, HYDROGENATION REDUCTION CATALYST, DEHYDROGENATION CATALYST, METHOD FOR PRODUCING HYDROGENATION REDUCTION PRODUCT, METHOD FOR PRODUCING HYDROGEN (H2), AND METHOD FOR PRODUCING DEHYDROGENATION REACTION PRO

OSAKA UNIVERSITY, Osaka ...

1. A mononuclear metal complex represented by following formula (4); a tautomer or a stereoisomer of the mononuclear metal
complex; or a salt of the mononuclear metal complex, the tautomer, or the stereoisomer thereof:

where:
R1 to R5 are each independently a hydrogen atom or any substituent,

R6 to R12 are each independently a hydrogen atom or any substituent, or R9 and R10 may together form —CH?CH— where the hydrogen atoms may each independently be substituted with any substituent,

at least one of R6 to R9 is a carboxy group, a sulfo group, a phenolic hydroxyl group, a phosphate group, an amino group, or a hydroxymethyl group
the anionic group,

Q0 is C or N,

Q6 to Q12 are each independently C or N+,

or at least one pair of QX and RX having same X, where X is any integer from 6 to 12, may together form N, and

M is an atom or ion of a transition metal,
L is any ligand or is not present, and
m is a positive integer, O, or a negative integer.
US Pat. No. 9,097,717

METHODS OF KILLING MYELOMA STEM AND PRECURSOR CELLS BY ADMINISTERING ANTI-CD48 ANTIBODIES

OSAKA UNIVERSITY, Osaka ...

1. A method of treating multiple myeloma in a patient, comprising administrating to a patient having multiple myeloma an anti-human
CD48 monoclonal antibody, wherein said treatment kills myeloma stem cells and/or myeloma precursor cells.
US Pat. No. 9,603,919

METHOD FOR PROPHYLAXIS OF INFLUENZA USING VACCINE FOR INTRANASAL ADMINISTRATION

JAPAN AS REPRESENTED BY T...

1. A composition for nasal mucosal administration, comprising at least one influenza virus antigen, polyriboinosinic polyribocytidylic
acid (poly (I:C)) or a derivative thereof and a carboxyvinyl polymer,
wherein the weight ratio of the influenza virus antigen and the poly (I:C) or derivative thereof is 1:1-1:50, and
wherein the concentration of the carboxyvinyl polymer in the composition is 0.1 to 2.0 wt %.
US Pat. No. 9,605,053

INFLUENZA VIRUS-NEUTRALIZING ANTIBODY AND SCREENING METHOD THEREFOR

Fujita Health University,...

1. A method of passive immunotherapy for influenza comprising administering an effective amount of an antibody to a mammalian
or avian subject that has been infected, or can get infected, with influenza virus, wherein the antibody is an isolated antibody
comprising a heavy chain variable region comprising SEQ ID NO:15 and a light chain variable region comprising SEQ ID NO:26,
whereby the antibody binds influenza virus HA.

US Pat. No. 9,366,614

POROSITY MEASURING DEVICE AND POROSITY MEASURING METHOD

OSAKA UNIVERSITY, Osaka ...

1. A porosity measuring device comprising:
a magnetic field generating section;
a dispersoid measuring section configured to measure movement of a dispersoid dispersed in a dispersion medium in a state
where a magnetic field is generated by the magnetic field generating section; and

an operating section configured to obtain a porosity of the dispersoid on the basis of a measurement result of the dispersoid
measuring section,

wherein the operating section obtains a magnetophoretic velocity of the dispersoid from the measurement result of the dispersoid
measuring section, obtains a volume susceptibility of the dispersoid from the magnetophoretic velocity of the dispersoid,
and obtains the porosity of the dispersoid on the basis of the volume susceptibility of the dispersoid, a volume relationship
of the dispersoid, and a relationship in magnetization of the dispoersoid.

US Pat. No. 9,181,328

HUMAN MONOCLONAL ANTIBODIES BROADLY PROTECTIVE AGAINST INFLUENZA B VIRUS AND METHODS OF USING THE SAME

OSAKA UNIVERSITY, Osaka ...

4. An anti-human influenza virus monoclonal antibody or antigen-binding fragment thereof, which has a neutralization activity
against a human influenza B virus and recognizes the amino acid residues of an hemagglutinin (HA) protein at positions corresponding
to any one of the following positions (i) and (ii):
(i) position 315 to 324 of SEQ ID NO: 29; and
(ii) positions 131, 194, 196 and 227 of SEQ ID NO: 29.

US Pat. No. 10,139,703

ISING MODEL QUANTUM COMPUTATION DEVICE

NIPPON TELEGRAPH AND TELE...

1. An Ising model quantum computation device comprising:a degenerate optical parametric oscillator which causes degenerate optical parametric oscillation of a plurality of pseudo spin pulses corresponding to a plurality of spins in the Ising model in a pseudo manner and having an identical oscillation frequency;
a ring resonator which circularly propagates the plurality of pseudo spin pulses;
a temporary spin measuring unit which temporarily measures pseudo spins of the plurality of pseudo spin pulses by temporarily measuring phases of the plurality of pseudo spin pulses every time the plurality of pseudo spin pulses circularly propagate in the ring resonator, and suspends measurement after one set of measurement is completed before another set of measurement is restarted;
an interaction computing unit which temporarily computes all interactions relating to the plurality of pseudo spin pulses, on the basis of the coupling coefficients of the Ising model and the pseudo spins of the plurality of pseudo spin pulses which the temporary spin measuring unit has most recently measured, after the temporary spin measuring unit completes one set of measurement before the temporary spin measuring unit restarts another set of measurement;
an interaction implementing unit which temporarily implements magnitudes and signs of all the interactions relating to the plurality of pseudo spin pulses which the interaction computing unit has most recently computed, by controlling amplitudes and phases of light injected to the plurality of pseudo spin pulses, after the interaction computing unit completes a temporary computation of all the interactions relating to the plurality of pseudo spin pulses; and
a pseudo spin measuring unit which measures the pseudo spins of the plurality of pseudo spin pulses by measuring the phases of the plurality of pseudo spin pulses after the plurality of pseudo spin pulses reach a steady state while a feedback loop constituted by the temporary spin measuring unit, the interaction computing unit, and the interaction implementing unit is repeated.

US Pat. No. 9,728,785

ACTIVE MATERIAL FOR SODIUM ION BATTERY, AND SODIUM ION BATTERY

Toyota Jidosha Kabushiki ...

1. An active material for a sodium ion battery comprising:
(t-butyl)3-trioxotriangulene represented by the following Formula (1),


wherein in Formula (1), a double line including a solid line and a broken line represents a single bond or a double bond,
wherein the active material is a negative electrode active material for the sodium ion battery.

US Pat. No. 9,650,357

REAGENT FOR ENHANCING GENERATION OF CHEMICAL SPECIES

Toyo Gosei Co., Ltd., Ic...

1. A composition, comprising:
a reagent;
a first compound able to react with a chemical species to cause a deprotection reaction of the first compound; and
a precursor,
wherein the reagent is selected from the group consisting of a first reagent, a second reagent, and a third reagent,
the first reagent being represented by one of formula (I),

wherein
R1 is a hydrogen atom;

R2 is a phenyl group, an alkyl carbonyl group, an aryl carbonyl group, an alkyl group, an alkenyl group, an aralkyl group, an
alkynyl group, an alkyl group containing a cyclic or poly cyclic moiety, or a substituent containing at least one atom other
than carbon atom and hydrogen atom; and

R3 is a hydrogen atom, a phenyl group, an alkyl carbonyl group, an aryl carbonyl group, an alkyl group, an alkenyl group, an
aralkyl group, an alkynyl group, an alkyl group containing a cyclic or poly cyclic moiety, or a substituent containing at
least one atom other than carbon atom and hydrogen atom,

the second reagent being represented by one of formula (II),

wherein
R1 is a hydrogen atom;

R2 is a phenyl group, an alkyl carbonyl group, an aryl carbonyl group, an alkyl group, an alkenyl group, an aralkyl group, an
alkynyl group, an alkyl group containing a cyclic or poly cyclic moiety, or a substituent containing at least one atom other
than carbon atom and hydrogen atom;

R3 is a hydrogen atom, a phenyl group, an alkyl carbonyl group, an aryl carbonyl group, an alkyl group, an alkenyl group, an
aralkyl group, an alkynyl group, an alkyl group containing a cyclic or poly cyclic moiety, or a substituent containing at
least one atom other than carbon atom and hydrogen atom; and

R4 is a protective group for a hydroxyl group or a group containing a carbon atom; and

the third reagent includes a hydroxyl group and a first cyclic moiety that contains a carbon atom bonded to the hydroxyl group
and a hydrogen atom;

wherein:
an intermediate is generated from the reagent by a feed energy;
the intermediate enhances a generation of the chemical species from a precursor;
a product resulting from the intermediate has a conjugation length longer than a conjugation length of the reagent;
wherein the feed energy is carried out by a first irradiation of the reagent or an acceptor receiving the energy with at least
one of a light, the wavelength of which is shorter than or equal to 15 nm and an electron beam; and

wherein the generation of the chemical species from the precursor is improved by a second irradiation with a light, the wavelength
of which is longer than or equal to 300 nm.

US Pat. No. 9,458,429

MESENCHYMAL STEM CELL ATTRACTANT AND METHOD FOR ATTRACTING MESENCHYMAL STEM CELL

Pias Corporation, Osaka ...

1. A method for treating an injury to skin tissue, muscle tissue, cartilage tissue or liver tissue of a subject, comprising
enhancing the migratory capacity of mesenchymal stem cells in the blood of the subject whereby to attract the mesenchymal
stem cells to the injury site to thereby reduce injury healing time by determining the site of injury to said tissue then
applying an effective amount of a mesenchymal stem cell attractant comprising an extract of Mallotus philippinensis to the injury site.
US Pat. No. 9,399,788

METHOD FOR INSPECTING SUSCEPTIBILITY OF BACTERIA OR FUNGI TO ANTIMICROBIAL DRUG AND SYSTEM FOR USE IN THE SAME

Osaka University, Osaka ...

1. A method for inspecting a susceptibility of bacteria or fungi to an antimicrobial drug using a micro-device having a plurality
of flow channels, comprising:
providing a suspension to be inspected to a micro-device having a plurality of flow channels in which an antimicrobial drug
already is present, the respective flow channels differing from one another in at least one selected from the identity and
the concentration of the antimicrobial drug;

incubating a mixture of the antimicrobial drug and a suspension to be inspected in the plurality of flow channels of the micro-device,
and

detecting with a microscope, bacteria or fungi derived from the suspension to be inspected in an observation area of each
of the plurality of flow channels of the micro-device, wherein, in the micro-device,

the antimicrobial drug is placed in each of the plurality of flow channels before introducing the suspension to be inspected
into the flow channels,

the plurality of flow channels have a common inlet,
each of the flow channels comprises the common inlet, the observation area, and an exhaust section in this order,
the plurality of flow channels are in parallel and positioned to be in a field of view of the microscope in the observation
areas,

the observation areas of the plurality of flow channels all have the same width and the same length,
in each of the flow channels, a length of a part extending from an exhaust section-side end of the observation area to the
exhaust section is shorter than that of a part extending from a common inlet side end of the observation area to the common
inlet, and

wherein, in the incubating step, the suspension to be inspected is introduced into each of the flow channels via the common
inlet of the micro-device, and

all of the observation areas of the plurality of flow channels are observable within a field of view of the microscope at
the same time and all of the observation areas of the plurality of flow channels are inspected with the microscope at the
same time.

US Pat. No. 9,075,284

SPECTRAL WIDTH NARROWING METHOD, OPTICAL ELEMENT AND LIGHT SOURCE DEVICE

OSAKA UNIVERSITY, Osaka ...

1. A method for narrowing a spectral width of the optical pulse comprising:
introducing an input optical pulse into an optical waveguide member that causes a soliton effect in the input optical pulse
introduced into the optical waveguide member, thereby narrowing a spectral width of the input optical pulse so as to provide
an output optical pulse having the narrowed spectral width,

the optical waveguide member having dispersion characteristics such that:
an average of a second-order dispersion value (b2) relative to the input optical pulse is negative, and

an absolute value of the second-order dispersion value (b2) increases, while an increment of the absolute value gradually decreases, in a propagation direction of the input optical
pulse.

US Pat. No. 9,707,544

SILVER-CERIUM OXIDE COMPOSITE CATALYST SUPPORTED ON AN ALKALINE CARRIER AND METHOD FOR PRODUCING THE SAME

OSAKA UNIVERSITY, Suita-...

1. A silver-cerium oxide supported composite catalyst comprising:
a silver-cerium oxide composite and
an alkaline carrier having supported thereon the oxide composite,
wherein the silver-cerium oxide composite comprises a silver particle and cerium oxide covering the surface of the silver
particle.

US Pat. No. 9,166,624

ERROR-CORRECTING CODE PROCESSING METHOD AND DEVICE

OSAKA UNIVERSITY, Osaka ...

1. A CRC coding method for calculating, as check symbols, coefficients of a remainder polynomial through a first operation,
generating a code word by combining the check symbols and information symbols, and transmitting the code word as data, the
first operation being calculating a remainder by dividing, by a generator polynomial, a shift information symbol polynomial
obtained by multiplying, by xk (k is a degree of the generator polynomial), an information symbol polynomial obtained by expressing the information symbols
in a polynomial having x as a variable (modulo 2), the method comprising:
generating, by multiplying only a matrix G by a matrix G a predetermined number of times in advance, a submatrix that represents
a sub operation unit of the first operation after a second operation is repeated the predetermined number of times, the second
operation being (i) deleting in stages each of terms from a highest degree of the variable x of the shift information symbol
polynomial in the first operation by multiplying the generator polynomial by a power of the variable x and subtracting the
product from each term and (ii) represented by a product of a vector obtained by arranging coefficients of the shift information
symbol polynomial and a corresponding matrix G and a product of a vector obtained by arranging remainder coefficients of the
shift information symbol polynomial still in one of the stages of the deletion and a corresponding matrix G; and

generating the check symbols by sequentially performing an operation starting from calculating, as a remainder vector still
in one of the stages, a product of a vector of the shift information symbol polynomial and the submatrix, to calculating,
as a next remainder vector still in one of the stages, a product of the remainder vector still in the stage and the submatrix
for each of the predetermined number of times.

US Pat. No. 10,073,348

RESIST-PATTERN-FORMING METHOD AND CHEMICALLY AMPLIFIED RESIST MATERIAL

OSAKA UNIVERSITY, Suita-...

1. A resist-pattern-forming method comprising:patternwise exposing a predetermined region of a resist material film made from a photosensitive resin composition comprising a chemically amplified resist material to a first radioactive ray that is ionizing radiation or nonionizing radiation having a wavelength of no greater than 400 nm;
floodwise exposing the resist material film patternwise exposed, to a second radioactive ray that is nonionizing radiation having a wavelength greater than the nonionizing radiation for the patternwise exposing and greater than 200 nm;
baking the resist material film floodwise exposed; and
developing the resist material film baked with a developer solution to form a resist pattern,
the chemically amplified resist material comprising:
a base component that is capable of being made soluble or insoluble in the developer solution by an action of an acid; and
a generative component that is capable of generating a radiation-sensitive sensitizer and an acid upon an exposure,
wherein the generative component comprises:
at least one radiation-sensitive acid-and-sensitizer generating agent;
the at least one radiation-sensitive acid-and-sensitizer generating agent and at least one a radiation-sensitive sensitizer generating agent;
the at least one radiation-sensitive acid-and-sensitizer generating agent and at least one radiation-sensitive acid generating agent;
the at least one radiation-sensitive sensitizer generating agent and the at least one radiation-sensitive acid generating agent; or
the at least one radiation-sensitive acid-and-sensitizer generating agent, the at least one radiation-sensitive sensitizer generating agent, and the at least one radiation-sensitive acid generating agent,
wherein
the radiation-sensitive acid-and-sensitizer generating agent generates, upon the exposure to the first radioactive ray, an acid, and a radiation-sensitive sensitizer absorbing the second radioactive ray, and substantially does not generate the acid and the radiation-sensitive sensitizer upon the exposure to the second radioactive ray, in light-unexposed regions that are not exposed to the first radioactive ray in the patternwise exposing,
the radiation-sensitive sensitizer generating agent generates, upon the exposure to the first radioactive ray, a radiation-sensitive sensitizer absorbing the second radioactive ray, and substantially does not generate the radiation-sensitive sensitizer upon the exposure to the second radioactive ray, in light-unexposed regions that are not exposed to the first radioactive ray in the patternwise exposing, and
the radiation-sensitive acid generating agent generates an acid upon the exposure to the first radioactive ray, and substantially does not generate the acid upon the exposure to the second radioactive ray, in light-unexposed regions that are not exposed to the first radioactive ray in the patternwise exposing,
wherein a van der Waals volume of an acid generated from the generative component is no less than 3.0×10?28 m3 and
wherein the radiation-sensitive acid-and-sensitizer generating agent or the radiation-sensitive acid generating agent is an onium salt compound, and an anion of the onium salt compound is represented by formula (1):

wherein, in the formula (1),
Rp1 represents a monovalent group having 8 or more ring atoms;
Rp2 represents a divalent linking group;
Rp3 and Rp4 each independently represent a hydrogen atom, a fluorine atom, a monovalent hydrocarbon group having 1 to 20 carbon atoms or a monovalent fluorinated hydrocarbon group having 1 to 20 carbon atoms;
Rp5 and Rp6 each independently represent a fluorine atom or a monovalent fluorinated hydrocarbon group having 1 to 20 carbon atoms;
np1 is an integer of 0 to 10;
np2 is an integer of 0 to 10; and
np3 is an integer of 2,
wherein in a case where np1 is no less than 2, a plurality of Rp2s are identical or different, in a case where np2 is no less than 2, a plurality of Rp3s are identical or different and a plurality of Rp4s are identical or different, and a plurality of Rp5s are identical or different and a plurality of Rp6s are identical or different.
US Pat. No. 9,816,089

CHIMERIC DOUBLE-STRANDED NUCLEIC ACID

National University Corpo...

1. A method of reducing the level of a transcription product in a cell comprising contacting the cell with a composition comprising:
a double-stranded nucleic acid complex comprising a first nucleic acid strand annealed to a second nucleic acid strand, wherein:
(i) the first nucleic acid strand is 8 to 100 nucleotides in length and hybridizes to the transcription product, comprises
(a) a region consisting of at least 4 consecutive DNA nucleotides that are recognized by RNase H when the strand is hybridized
to the transcription product, wherein the at least 4 consecutive DNA nucleotides may be modified or unmodified, and further
comprises (b) one or more nucleotide analogs located on 5? terminal side of the region, and (c) one or more nucleotide analogs
located on 3? terminal side of the region; and

(ii) the second nucleic acid strand (a) comprises at least 4 consecutive RNA nucleotides, and (b) further comprises a 5? wing
region of one or more modified nucleotides, nucleotide analogs and/or modified nucleotide analogs located 5? to the at least
4 consecutive RNA nucleotides, and/or a 3? wing region of one or more modified nucleotides, nucleotide analogs and/or modified
nucleotide analogs located 3? to the at least 4 consecutive RNA nucleotides, wherein the at least 4 consecutive RNA nucleotides
can be cleaved by RNase H when the second nucleic acid strand is annealed with the first nucleic acid strand, and wherein
the second nucleic acid strand further comprises a functional moiety having a function selected from a labeling function,
a purification function, and a targeted delivery function.

US Pat. No. 9,194,838

METHOD AND DEVICE FOR IDENTIFYING NUCLEOTIDE, AND METHOD AND DEVICE FOR DETERMINING NUCLEOTIDE SEQUENCE OF POLYNUCLEOTIDE

OSAKA UNIVERSITY, Osaka ...

1. A method for sequencing a nucleic acid molecule, comprising:
(a) providing a solid substrate comprising a pair of electrodes that at least partially define a gap, wherein said gap has
a distance that is less than a molecular diameter of said nucleic acid molecule;

(b) moving said nucleic acid molecule through said gap;
(c) detecting pulses of a tunnel current across said gap using said pair of electrodes, which pulses correspond to individual
nucleic acid subunits of said nucleic acid molecule;

(d) calculating a modal value of current of said pulses detected in (c); and
(e) comparing said modal value calculated in (d) against a reference value to identify an individual nucleic acid subunit
of said nucleic acid molecule.

US Pat. No. 10,011,921

METHOD FOR PRODUCING GROUP III ELEMENT NITRIDE CRYSTAL, GROUP III ELEMENT NITRIDE CRYSTAL, SEMICONDUCTOR DEVICE, METHOD FOR PRODUCING SEMICONDUCTOR DEVICE, AND GROUP III ELEMENT NITRIDE CRYSTAL PRODUCTION DEVICE

Osaka University, Osaka ...

1. A method for producing a Group III element nitride crystal, the method comprising:a vapor phase growth step of growing a Group III element nitride crystal on a crystal growth surface of a Group III element nitride seed crystal by vapor deposition, wherein
the vapor phase growth step is a step of causing a Group III metal, an oxidant, and a nitrogen-containing gas to react with one another to grow the Group III element nitride crystal, or
the vapor phase growth step comprises:
a reduced product gas generation step of causing a Group III element oxide and a reducing gas to react with each other to generate a gas of a reduced product of the Group III element oxide; and
a crystal generation step of causing the gas of the reduced product and a nitrogen-containing gas to react with each other to generate the Group III element nitride crystal,
the crystal growth surface is a surface on a ?c-plane side,
a crystal growth temperature is 1200° C. or more, and
in the vapor phase growth step, the Group III element nitride crystal is grown in an approximately ?c direction.
US Pat. No. 9,971,247

PATTERN-FORMING METHOD

OSAKA UNIVERSITY, Suita-...

1. A pattern-forming method comprising:applying a chemically amplified resist material on an antireflective film formed on a substrate to form a resist material film;
patternwise exposing the resist material film to ionizing radiation or nonionizing radiation having a wavelength of no greater than 400 nm;
floodwise exposing the resist material film patternwise exposed, to nonionizing radiation having a wavelength greater than the nonionizing radiation for the patternwise exposing and greater than 200 nm;
baking the resist material film floodwise exposed; and
developing with a developer solution the resist material film baked,
wherein
an extinction coefficient of the antireflective film for the nonionizing radiation employed for the floodwise exposing is no less than 0.1, and
the chemically amplified resist material comprises:
a base component that is made soluble or insoluble in the developer solution by an action of an acid; and
a generative component that is capable of generating a radiation-sensitive sensitizer and an acid upon an exposure,
wherein the generative component comprises: a radiation-sensitive acid-and-sensitizer generating agent; any two among the radiation-sensitive acid-and-sensitizer generating agent, a radiation-sensitive sensitizer generating agent and a radiation-sensitive acid generating agent, or all the radiation-sensitive acid-and-sensitizer generating agent, the radiation-sensitive sensitizer generating agent and the radiation-sensitive acid generating agent,
wherein
the radiation-sensitive acid-and-sensitizer generating agent is capable of generating, upon an exposure to the ionizing radiation or the nonionizing radiation in the patternwise exposing, an acid and a radiation-sensitive sensitizer that absorbs the nonionizing radiation in the floodwise exposing, and is not substantially capable of generating the acid and the radiation-sensitive sensitizer during the floodwise exposing, in light-unexposed regions in the patternwise exposing,
the radiation-sensitive sensitizer generating agent is capable of generating, upon the exposure to the ionizing radiation or the nonionizing radiation in the patternwise exposing, the radiation-sensitive sensitizer that absorbs the nonionizing radiation in the floodwise exposing, and is not substantially capable of generating the radiation-sensitive sensitizer during the floodwise exposing, in the light-unexposed regions in the patternwise exposing, and
the radiation-sensitive acid generating agent is capable of generating the acid upon the exposure to the ionizing radiation or the nonionizing radiation in the patternwise exposing, and is not substantially capable of generating the acid during the floodwise exposing, in the light-unexposed regions in the patternwise exposing.
US Pat. No. 9,895,398

METHOD FOR COLLECTING FUNCTIONAL CELLS IN VIVO WITH HIGH EFFICIENCY

GENOMIX CO., LTD., Osaka...

1. A method for collecting bone-marrow-derived stem cells from a subject, wherein the method comprises:
(I) implanting for at least 12 hours a vessel that contains a substance of any of (a) to (j) below, completely under the skin
in subcutaneous adipose of the subject, to induce stem cells present in the bone marrow of the subject to migrate to the vessel
implanted in subcutaneous tissue, wherein, as a result of the presence of the substance, stem cells present in bone marrow
of the subject enter the vessel implanted in subcutaneous adipose:

(a) an HMGB1 protein,
(b) a cell that secretes an HMGB1,
(c) an HMGB2 protein,
(d) a cell that secretes an HMGB2,
(e) an HMGB3 protein,
(f) a cell that secretes an HMGB3 protein,
(g) an S100A8 protein,
(h) a cell that secretes an S100A8 protein,
(i) an S100A9 protein,
and (j) a cell that secretes an S100A9 protein,
wherein the vessel is made from a material that is biologically hypoallergenic when implanted into the subject without any
of (a) to (j), and wherein the vessel has one closed end to form an area therein to collect the bone-marrow-derived stem cells;
and

(II) collecting bone-marrow-derived stem cells from the vessel.
US Pat. No. 9,802,963

FLUORINE-CONTAINING COMPLEX COMPOUND, AND PRODUCTION METHOD FOR FLUORINE-CONTAINING ORGANIC COMPOUND EMPLOYING SAME

DAIKIN INDUSTRIES, LTD., ...

1. A fluorine-containing compound represented by formula (4-1):
(Ra1S—)ma1Ra1L—CF2—CF2—Ra2L(—Ra2S)ma2  (4-1)
wherein
the moiety represented by formula:(Ra1S—)ma1Ra1L indicates Ra1L substituted with ma1 Ra1S;

the moiety represented by formula: Ra2L(—Ra2S)ma2 indicates Ra2L substituted with ma2 Ra2S;

Ra1Sand Ra2S are the same or different, and each represents independently a moiety selected from the group consisting of

(1) aldehyde,
(2) alkenyl optionally substituted with at least one halogen atom,
(3) alkynyl optionally substituted with at least one substituent selected from the group consisting of halogen and trimethylsilyl,
(4) epoxy,
(5) (meta)acryloyl optionally substituted with at least one halogen atom, and
(6) alkyl and alkoxy each substituted with at least one substituent selected from the group consisting of:
(a) cyano group,
(b) aldehyde,
(c) alkynyl optionally substituted with at least one halogen atom,
(d) vinyl optionally substituted with at least one halogen atom,
(e) epoxy, and
(f) (meta)acryloyl optionally substituted with at least one halogen atom,
ma1 and ma2 are independently 0 or 1, and the sum of ma1 and ma2 is 1 or 2 ;
Ra1L and Ra2L are the same or different, and each represents a phenyl group optionally having, in addition to ma1 Ra1S or ma2 Ra2S, at least one substituent selected from the group consisting of fluoro group, perfluoro organic group, and pentafluorosulfanyl.

US Pat. No. 9,719,110

METHOD OF INCREASING PRODUCTION OF AMORPHA-4,11-DIENE AND METHOD OF INCREASING PRODUCTION OF NATURAL RUBBER

SUMITOMO RUBBER INDUSTRIE...

1. A method of increasing production of natural rubber,
the method comprising the step of attaching an enzyme inhibitor to a rubber-producing plant,
the enzyme inhibitor inhibiting at least one enzyme other than enzymes involved in natural rubber synthesis, that catalyzes
an enzymatic reaction in which farnesyl diphosphate acts as a substrate.

US Pat. No. 9,493,550

HUMAN ANTI-HUMAN INFLUENZA VIRUS ANTIBODY

Osaka University, Osaka ...

1. An isolated human anti-human influenza virus monoclonal antibody, comprising a variable region comprising:
a heavy chain comprising the amino acid sequence of SEQ ID NO: 31 and a light chain comprising the amino acid sequence of
SEQ ID NO: 32; or

a heavy chain comprising the amino acid sequence of SEQ ID NO: 33 and a light chain comprising the amino acid sequence of
SEQ ID NO: 34.

US Pat. No. 9,486,465

ATTRACTANT FOR BONE MARROW STEM CELLS AND METHOD FOR ATTRACTING BONE MARROW STEM CELLS

Pias Corporation, Osaka ...

1. A method of treating a skin wound, comprising
attracting bone marrow stem cells by application of a bone marrow stem cell attractant comprising cinnamtannin B1 to a wound
site of a skin epidermal tissue of a mammal.

US Pat. No. 9,463,204

METHOD FOR INDUCING DIFFERENTIATION ENABLING TUMORIGENESIS OF IPS CELLS TO BE SUPPRESSED

Osaka University, Suita-...

1. A method for inducing differentiation of iPS cells while suppressing tumorigenesis, the method comprising:
adding to the iPS cells a statin and a differentiation inducer, wherein the differentiation inducer is known to cause differentiation
of the iPS cells into osteoblasts, and

permitting differentiation of the iPS cells into osteoblasts, wherein the differentiation of the iPS cells is induced by the
differentiation inducer, and wherein tumorigenesis is suppressed by the statin,

wherein the statin is a compound represented by General formula (A) below:

wherein the carboxyl group may form a ring structure with the hydroxyl group in the third position, and Ri represents any
of the groups shown in General Formulas (1) and (2) below:


wherein R1a and R1b may be the same or different, and are each hydrogen atoms or C1-5 linear or branched alkyl groups; and R1c and R1d may be the same or different, and are each hydrogen atoms, hydroxyl groups or C1-5 linear or branched alkyl groups;


wherein R2a is a halogen-substituted phenyl group, and R2b is a C1-5 linear or branched alkyl group.

US Pat. No. 9,347,041

METHOD FOR PREPARING CORNEAL ENDOTHELIAL CELL

OSAKA UNIVERSITY, Osaka ...

1. A method for preparing corneal endothelial progenitor cells comprising:
a step (a) of isolating cells dissociated from corneal endothelial cell tissue, wherein the corneal endothelial cell tissue
had previously been incubated in a culture medium comprising a ROCK inhibitor; and

a step (b) of cultivating the isolated cells of step (a) at an initial seeding density of 20 to 2000 cells/cm2 by adherent cultivation in a serum-free medium, thereby obtaining a primary cell population of the corneal endothelial progenitor
cells.

US Pat. No. 10,073,085

METHOD FOR PRODUCING ARTIFICIAL SKIN MODEL, AND ARTIFICIAL SKIN MODEL

Osaka University, Osaka ...

1. A production method for producing an artificial skin model, comprising:providing cells;
providing, separately from the cells, a first material having an RGD sequence;
providing, separately from the cells, a second material which interacts with the first material;
forming extracellular matrix coated cells;
forming a dermis tissue layer, in which the extracellular matrix coated cells are laminated, by culturing the extracellular matrix coated cells; and
forming an epidermis layer by arranging epidermis cells on the dermis tissue layer,
wherein each of the extracellular matrix coated cells comprises:
a cell, and
a coating film coating the cell, wherein the coating film includes the first material and the second material, and at least one of the first material and the second material includes an extracellular matrix component,
the forming of the extracellular matrix coated cells comprises:
forming first material coated cells by contacting the first material to the cells by at least one selected from:
(a) soaking the cells in a liquid containing the first material,
(b) dripping the liquid containing the first material to the cells, and
(c) spraying the liquid containing the first material to the cells; and
then contacting the second material to the first material coated cells by at least one selected from:
(d) soaking the first material coated cells in a liquid containing the second material,
(e) dripping the liquid containing the second material to the first material coated cells, and
(f) spraying the liquid containing the second material to the first material coated cells,
wherein the first material is fibronectin, and the second material is gelatin.

US Pat. No. 9,968,716

DRUG-ELUTING STENT GRAFT

ONO PHARMACEUTICAL CO., L...

1. A drug-eluting stent graft comprising:(a) a drug;
(b) a drug-retaining agent; and
(c) a stent graft;
wherein the drug (a) comprises (E)-[5-[2-[1-phenyl-1-(3-pyridyl)methylidenaminoxy]ethyl]-7,8-dihydronaphthalen-1-yloxy]acetic acid or a salt thereof;
wherein the drug-retaining agent (b) is at least one selected from the group consisting of fibrin, gelatin, collagen and hyaluronic acid;
wherein the stent graft (c) is an artificial blood vessel used for intravascular surgery;
wherein the stent graft (c) has a structure in which a metal wire mesh tube is coated inside and/or outside thereof with a resin;
wherein the resin is in the form of fabric which has a thickness in the range of 10 to 160 ?m;
wherein a mixture containing the drug (a) and the drug-retaining agent (b) is coated on the outside (the side that contacts the intra-arterial wall) of the stent graft (c); and
wherein the drug (a) promotes fixation of the stent graft (c) to an aorta wall.
US Pat. No. 9,943,569

METHOD FOR PREVENTING OR REDUCING POSTOPERATIVE PULMONARY COMPLICATIONS

OSAKA UNIVERSITY, Suita-...

1. A method for reducing the incidence of postoperative pulmonary complications in a surgical patient after an esophagectomy, the method comprising:administering an effective amount of ghrelin to the surgical patient perioperatively, beginning at a time 1 day prior to and up to 7 days after the esophagectomy.

US Pat. No. 9,771,316

PHENOXYALKYLAMINE COMPOUND

Osaka University, Osaka ...

1. A compound represented by the formula (I):

wherein
Ring A is an optionally substituted cyclic group,
Ring B is an optionally substituted cyclic group,
R1 and R2 are each independently a hydrogen atom, an optionally substituted alkyl group or an optionally substituted cycloalkyl group,

X is O, S, S(O), or S(O)2, and

n is an integer of 4 to 6,
or a salt thereof.

US Pat. No. 9,672,944

METHOD OF DETERMINING NUCLEAR FUSION IRRADIATION COORDINATES, DEVICE FOR DETERMINING NUCLEAR FUSION IRRADIATION COORDINATES, AND NUCLEAR FUSION DEVICE

OSAKA UNIVERSITY, Suita-...

1. A method of determining nuclear fusion irradiation coordinates for calculating irradiation coordinates of energy lines
when the energy lines are irradiated onto nuclear fusion fuel, comprising:
virtually arranging a predetermined number of electric charges at a predetermined number of initial coordinates on a spherical
surface set by using random numbers by an information processing device;

analyzing coordinates of the predetermined number of electric charges arranged at the initial coordinates in time series based
on coulomb forces acting among the predetermined number of electric charges by constraining the coordinates onto the spherical
surface by the information processing device;

determining a timing at which potential energies of the predetermined number of electric charges were stabilized based on
the coordinates analyzed in the coordinate analysis step by the information processing device;

deriving coordinates of the predetermined number of electric charges at the timing determined in the potential evaluation
step as irradiation coordinates of the energy lines in a case where nuclear fusion fuel is arranged at the center of the spherical
surface by the information processing device; and

arranging a predetermined number of energy line sources at positions within a nuclear fusion device corresponding to the irradiation
coordinates when the nuclear fusion fuel is arranged at the center of the spherical surface.

US Pat. No. 9,455,376

SUBSTRATE FOR NITRIDE SEMICONDUCTOR DEVICE AND PRODUCTION METHOD THEREOF, AND RED LIGHT EMITTING SEMICONDUCTOR DEVICE AND PRODUCTION METHOD THEREOF

OSAKA UNIVERSITY, Suita-...

1. A production method of a substrate for nitride semiconductor device using a metal nitride, comprising
a mask formation step of using a metal nitride as a base material and forming a mask having a prescribed shape on the above-described
base material,

a three-dimensional structure growth step of growing a three-dimensional structure made of the same material as the above-described
base material on the above-described base material having the mask formed thereon using a selective growth technique so that
an undoped layer having a higher index plane than the above-described base material is formed on the lateral face, and

an active layer growth step of growing an active layer containing a rare earth element doped so as to replace a metal element
of the above-described metal nitride on the undoped layer on the lateral face of the above-described three-dimensional structure
using an organometallic vapor phase epitaxial method,

wherein the active layer having a desired high index plane is grown by regulating the growth conditions of the active layer
in the above-described active layer growth step.

US Pat. No. 9,271,336

METHOD OF ESTIMATING TEMPERATURE DISTRIBUTION HISTORY

JAPAN MARINE UNITED CORPO...

1. A method of estimating a temperature distribution history implemented by an apparatus for estimating temperature distribution
history of heated sheet steel for forming three-dimensional curved surfaces, comprising:
a first step of measuring, without electromagnetic analysis, a history of temperature distribution that is generated when
a test piece of sheet steel is spot-heated by high-frequency induction;

a second step of obtaining an induction current distribution, which is generated when the sheet steel is spot-heated by the
high-frequency induction, by using finite element analysis;

a third step of expressing the induction current distribution by an approximation equation of an initial induction current
distribution at an initial temperature and temperature dependent correction factors of the initial induction current, wherein
the initial induction current distribution and the temperature dependent correction factors are identified based on the temperature
distribution history obtained in the first step and the induction current distribution obtained in the second step;

a fourth step of obtaining internal heat generation from the initial induction current distribution, the temperature dependent
correction factors obtained in the third step, and a temperature dependency of electrical resistivity of the sheet steel;

a fifth step of obtaining the temperature distribution history generated during the line heating by the finite element analysis
by applying the internal heat generation that is obtained in the fourth step to the sheet steel while the internal heat generation
is being moved; and

automating forming of a three dimensional curved surface based on the temperature distribution history;
wherein said apparatus is a computer that includes a processor and a non-transitiory computer readable medium containing computer
instructions for causing the processor to perform at least the second to fifth steps wherein:

in the third step, the induction current distribution I(r, z, T) is expressed by the following approximation equation (1)
of the initial induction current distribution Io(r, z) at the initial temperature (To) and the temperature dependent correction
factors w(T) of the initial induction current, and the initial induction current distribution Io(r, z) and the temperature
dependent correction factors w(T) are identified based on the temperature distribution history obtained in the first step
and the induction current distribution obtained in the second step,

I(r, z, T)=Io(r, z)w(T)   (1)

r z denoting the position of the sheet steel, and T denoting the tem erature of the sheet steel; and
in the fourth step, the internal heat generation W is obtained by the finite element analysis based on the following equation
(2) from the initial induction current distribution Io(r, z) and the temperature dependent correction factor w(T) obtained
in the third step and the temperature dependency R(T) of electrical resistivity of the sheet steel,

W=Io(r, z)2w(T)2R(T).   (2)

US Pat. No. 10,071,051

WT1 PEPTIDE CANCER VACCINE COMPOSITION FOR TRANSDERMAL ADMINISTRATION

NITTO DENKO CORPORATION, ...

1. A method for inducing cellular immunity in a subject, which comprises transdermally administering to the subject a cancer vaccine composition comprising: (i) a WT1 peptide and/or a modified WT1 peptide; and (ii) a first cellular immunity induction promoter that is a pharmacologically acceptable acid or a pharmacologically acceptable salt thereof, wherein the pharmacologically acceptable acid is selected from the group consisting of isostearic acid, decanoic acid, myristic acid, and malic acid.
US Pat. No. 9,732,107

METHOD FOR PRODUCING BETA-HEMATIN CRYSTAL COMPRISING STEP OF HEATING

Osaka University, Osaka ...

1. A method for producing ?-hematin comprising adding an HCl aqueous solution to a solution of hemin chloride dissolved in
an NaOH aqueous solution, adding acetic acid dropwise thereto so as to adjust the pH level to 4 to 6, and heating the resulting
mixture to 80° C. or higher, wherein the ?-hematin crystals have a needle-like morphology, an average particle size of 0.6
to 1.2 ?m, and exhibit main peaks characteristics for angles of diffraction (2?) of 7.4°, 12.2°, 21.6°, and 24.1° in an X-ray
diffraction pattern obtained by powder X-ray diffractometry with Cu-K? rays, wherein each peak includes a plus-minus 0.2°
diffraction angle.
US Pat. No. 9,725,733

POLYNUCLEOTIDE ENCODING NF-YB DERIVED FROM JATROPHA AND USE THEREOF

OSAKA UNIVERSITY, Osaka ...

1. A vector comprising a heterologous nucleotide sequence and a polynucleotide with at least 99% identity to SEQ ID NO:6,
wherein expression of the polynucleotide enhances stress resistance in Jatropha compared to wild-type Jatropha.

US Pat. No. 9,618,844

REAGENT AND COMPOSITION OF RESIST

Toyo Gosei Co., Ltd., Ic...

1. A composition comprising:
a reagent;
a first compound that functions as a generation source of acid;
wherein a feed of an energy to the reagent or to an acceptor for the reagent receiving the energy generates an intermediate
from the reagent;

wherein the intermediate enhances generation of acid from a precursor, wherein the intermediate is a ketyl radical;
wherein the reagent is selected from the group consisting of a first reagent, a second reagent and a third reagent;
wherein:
the first reagent is represented by formula (I);

wherein:
R1 is a hydrogen atom;

R2 is a phenyl group, an alkyl carbonyl group, an aryl carbonyl group, an alkyl group, an alkenyl group, an aralkyl group, an
alkynyl group, an alkyl group containing a cyclic or poly cyclic moiety, or a substituent containing at least one atom other
than carbon atom and hydrogen atom; and

R3 is a hydrogen atom, a phenyl group, an alkyl carbonyl group, an aryl carbonyl group, an alkyl group, an alkenyl group, an
aralkyl group, an alkynyl group, an alkyl group containing a cyclic or poly cyclic moiety, or a substituent containing at
least one atom other than carbon atom and hydrogen atom;

the second reagent is represented by formula (II):

wherein:
Z is a carbonyl group, a methylene group, an alkoxymethylene, an aryloxymethylene, or a hydroxymethylene;
R4 is an aryl group or an aryl group containing an aromatic group and a substituent on the aromatic group containing at least
one atom other than carbon atom and hydrogen atom; and

R5 is a hydrogen atom, a phenyl group, an alkyl carbonyl group, an aryl carbonyl group, an alkyl group, an alkenyl group, an
aralkyl group, an alkynyl group, an alkyl group containing a cyclic or poly cyclic moiety, or a substituent containing at
least one atom other than carbon atom and hydrogen atom;

the third reagent includes: a hydroxyl group; and
a first cyclic moiety that contains a carbon atom bonded to the hydroxyl group and a hydrogen atom.

US Pat. No. 9,611,479

CROSSLINKED NUCLEOSIDE AND NUCLEOTIDE

Osaka University, Osaka ...

1. A compound represented by formula I below or a salt thereof:

wherein Base represents a purine-9-yl group or a 2-oxo-1,2-dihydropyrimidine-1-yl group that may have any one or more substituents
selected from group ?, where the group ? consists of a hydroxyl group, a hydroxyl group protected by a protective group for
nucleic acid synthesis, a C1 to C6 linear alkyl group, a C1 to C6 linear alkoxy group, a mercapto group, a mercapto group protected by a protective group for nucleic acid synthesis, a C1 to C6 linear alkylthio group, an amino group, a C1 to C6 linear alkylamino group, an amino group protected by a protective group for nucleic acid synthesis, and a halogen atom;

R2 and R3 each independently represent a hydrogen atom, a protective group for a hydroxyl group on nucleic acid synthesis, a C1 to C7 alkyl group that may be branched or form a ring, a C2 to C7 alkenyl group that may be branched or form a ring, a C3 to C10 aryl group that may have any one or more substituents selected from the group ? and that may contain a hetero atom, an aralkyl
group having a C3 to C12 aryl moiety that may have any one or more substituents selected from the group ? and that may contain a hetero atom, an acyl
group that may have any one or more substituents selected from the group ?, a silyl group that may have any one or more substituents
selected from the group ?, a phosphate group that may have any one or more substituents selected from the group ?, a phosphate
group protected by a protective group for nucleic acid synthesis, or —P(R4)R5, where R4 and R5 each independently represent a hydroxyl group, a hydroxyl group protected by a protective group for nucleic acid synthesis,
a mercapto group, a mercapto group protected by a protective group for nucleic acid synthesis, an amino group, a C1 to C5 alkoxy group, a C1 to C5 alkylthio group, a C1 to C6 cyanoalkoxy group, or an amino group substituted with a C1 to C6 alkyl group; and

R6 and R7 each independently represent a hydrogen atom; a C1 to C7 alkyl group that may be substituted with a C3 to C12 aryl group that may contain a hetero atom, and that may be branched or form a ring; or an aralkyl group having a C3 to C12 aryl moiety that may contain a hetero atom; or

R6 and R7 are taken together to represent —(CH2)n—, where n is an integer from 2 to 5.

US Pat. No. 9,550,861

METHOD FOR PRODUCING POLYANILINE HAVING SELF-DOPING FUNCTION AND ANTISTATIC AGENT CONTAINING POLYANILINE PRODUCED THEREBY

OSAKA UNIVERSITY, Osaka ...

1. A method for producing a polyaniline, comprising a step of polymerizing an aniline monomer compound represented by the
following general formula (4):

(wherein R1 is NH2 or NH3X, and X is a halogen atom;

R2 is each independently a substituent represented by the following general formula (5):


M1 and M2 are each independently selected from the group consisting of a hydrogen atom, alkali metal, alkaline earth metal, ammonium
group, and pyridinium group, with the proviso that when M1 or M2 is an alkaline earth metal, the structure is such that the alkaline earth metal atom is bound to two O? in one phosphonic acid group and M2 is not present, or such that the alkaline earth metal atom crosslinks O? of two phosphonic acid groups;

R3 is each independently selected from the group consisting of a halogen atom, alkyl group in which the number of carbon atoms
is 1 to 15, aralkyl group in which the number of carbon atoms is 7 to 34, alkoxy group in which the number of carbon atoms
is 1 to 15, alkylthio group in which the number of carbon atoms is 1 to 15, alkylamino group in which the number of carbon
atoms is 1 to 15, carboxyl group, carboxylic acid alkyl ester group in which the number of carbon atoms of the alkyl group
is 1 to 15, nitro group and cyano group;

m is an integer of 1 to 4;
n is an integer of 0 to 3; and
the sum of m and n is 1 to 4;
with the proviso that neither R2 nor R3 is present at the para position relative to R1); or

an aniline monomer mixture comprising the aniline monomer compound.

US Pat. No. 10,128,731

LINEAR VERNIER MOTOR

MITSUBISHI HEAVY INDUSTRI...

1. A linear vernier motor comprising:a stator configured to extend along a direction of an axis in a first direction; and
a mover configured to extend along the axis in the first direction, wherein a pole interval of the mover is different from that of the stator,
wherein one of the stator and the mover includes:
a plurality of first yokes arranged in the first direction; and
a plurality of coils arranged in the first direction,
wherein each of the plurality of first yokes is arranged between adjacent coils,
wherein the plurality of first yokes and the plurality of coils have a first periodic structure in which one period is composed of m units, where m is an integer equal to or more than two, of first yokes and m coils, and phases of the m coils are different from each other,
wherein the other one of the stator and the mover includes:
a plurality of second yokes arranged in the first direction; and
a plurality of permanent magnets arranged in the first direction,
wherein each of the plurality of second yokes is arranged between adjacent permanent magnets,
wherein the plurality of magnets are magnetized along the first direction and magnetization orientations of adjacent permanent magnets are opposite to each other,
wherein each of the plurality of coils is wound around the axis,
wherein the plurality of second yokes and the plurality of permanent magnets have a second periodic structure in which one period is composed of n magnet pairs, where n is an integer equal to or more than one, each of the n magnet pairs including two units of second yokes and two permanent magnets, and
wherein an one-period length in the axis direction of the first periodic structure and that of the second periodic structure are equal to each other with n=m±1.
US Pat. No. 9,963,491

PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF

GENOMIX CO., LTD., Osaka...

1. A method of stimulating migration of a cell, mobilizing a cell from bone marrow to peripheral blood, and/or regenerating a tissue, in the body of a subject, wherein said method comprises administering to the subject an effective amount of a substance of any one of (a) to (c) below;(a) a peptide consisting of a portion of an HMGB1 protein of SEQ ID NO:1 and having cell migration-stimulating activity;
(b) a cell secreting said peptide of (a); and
(c) a vector into which a DNA encoding said peptide of (a) is inserted, wherein said peptide has an activity of stimulating migration of a cell and said peptide consists of all or part of the amino acid sequence of positions 1 to 195 of SEQ ID NO:1.
US Pat. No. 9,919,010

METHOD FOR COLLECTING FUNCTIONAL CELLS IN VIVO WITH HIGH EFFICIENCY

GENOMIX CO., LTD., Osaka...

1. A method for collecting bone-marrow-derived stem cells from a subject, wherein the method comprises:
(I) implanting for at least 12 hours a vessel that contains a substance of any of (a) to (j) below, completely under the skin
in subcutaneous adipose of the subject, to induce stem cells present in the bone marrow of the subject to migrate to the vessel
implanted in subcutaneous tissue, wherein, as a result of the presence of the substance, stem cells present in bone marrow
of the subject enter the vessel implanted in subcutaneous adipose:

(a) an HMGB1 protein,
(b) a cell that secretes an HMGB1,
(c) an HMGB2 protein,
(d) a cell that secretes an HMGB2,
(e) an HMGB3 protein,
(f) a cell that secretes an HMGB3 protein,
(g) an S100A8 protein,
(h) a cell that secretes an S100A8 protein,
(i) an S100A9 protein,
and (j) a cell that secretes an S100A9 protein,
wherein the vessel is made from a material that is biologically hypoallergenic when implanted into the subject without any
of (a) to (j), and wherein the vessel has one closed end to form an area therein to collect the bone-marrow-derived stem cells;
and

(II) collecting bone-marrow-derived stem cells from the vessel.

US Pat. No. 9,855,394

INSUFFLATION SYSTEM AND INSUFFLATION APPARATUS

FUJIFILM Corporation, To...

1. An insufflation system which insufflates a gas supplied from a gas supply source into a lumen of a living body, the insufflation
system comprising:
a first insufflation conduit through which the gas is automatically insufflated into the lumen;
a second insufflation conduit through which the gas is insufflated into the lumen by manual operation;
a pressure sensor configured to detect a pressure inside the lumen;
a first solenoid valve configured to control an insufflation flow rate of the first insufflation conduit;
a second solenoid valve configured to control an insufflation flow rate of the second insufflation conduit; and
a control unit configured to control operations of the first solenoid valve and the second solenoid valve;
wherein the control unit controls the insufflation flow rate of the first insufflation conduit based on a pressure difference
between the pressure detected by the pressure sensor and a preset set pressure and determines whether or not the gas is insufflated
through one or both of the first insufflation conduit and the second insufflation conduit,

when a determined result is determined that the gas is insufflated through both of the first insufflation conduit and the
second insufflation conduit, the second solenoid valve is controlled, and the insufflation flow rate of the gas insufflated
through the second insufflation conduit is set as a first insufflation flow rate MF1,

when a determined result is determined that the gas is not insufflated through the first insufflation conduit, the second
solenoid valve is controlled, and the insufflation flow rate of the gas insufflated through the second insufflation conduit
is set as a second insufflation flow rate MF2 greater than the first insufflation flow rate MF1.

US Pat. No. 9,726,636

SINGLE PARTICLE ANALYZER AND SINGLE PARTICLE ANALYSIS METHOD

KABUSHIKI KAISHA TOSHIBA,...

6. A single particle analysis method, comprising:
(1) preparing a single particle analyzing device comprising a measuring vessel, a first chamber and a second chamber in the
measuring vessel defined by an insulating membrane, a pore opening in the membrane to connect the first chamber to the second
chamber, and a first electrode in the first chamber and a second electrode in the second chamber, and

wherein the analyzing device satisfies the following dimensional relationships:
t where d is a diameter of the pore, which is in a range of greater than or equal to 50 nm and less than or equal to 1 mm, the
diameter d is greater than a diameter of a target, and t is a thickness of the membrane in the proximity to the pore, which
is in a range of greater than or equal to 10 nm and less than or equal to 500 nm, the thickness t being less than the diameter
of the target,

(2) charging a conductive liquid into the first and second chambers;
(3) introducing targets into the first chamber; and
(4) measuring a shape of the target by applying electric current between the first and second electrodes through the pore
in the membrane and measuring a signal detected during translocation of the target from the first chamber to the second chamber
through the pore.

US Pat. No. 9,725,396

ACTIVE MATERIAL, AND SODIUM ION BATTERY AND LITHIUM ION BATTERY USING THE SAME

Toyota Jidosha Kabushiki ...

1. An active material used for a sodium ion battery or a lithium ion battery, the active material comprising:
(COONa)3-trioxotriangulene represented by the following Formula (1) or (COOLi)3— trioxotriangulene represented by the following Formula (2), wherein


in Formulae (1) and (2), a double line including a solid line and a broken line represents a single bond or a double bond.
US Pat. No. 9,644,119

MATERIAL SELF-ASSEMBLY METHOD AND SELECTIVE ADHESION METHOD BASED ON MOLECULAR RECOGNITION

Osaka University, Suita-...

1. A polymer that has one or more host groups and one or more guest groups on the side chains,
wherein the association constant between the one or more host groups and the one or more guest groups is 50 or more; and
wherein the combination of the one or more host groups and the one or more guest groups is at least one member selected from
the following combinations (a) to (c):

(a) the one or more host groups are ?-cyclodextrins, and
the one or more guest groups are at least one member selected from the group consisting of (1) C4-18 linear alkyl groups,
(2) C4-18 linear alkyl groups having a hydroxyl group, (3) C4-18linear alkyl groups having a carboxyl group, (4) C4-18 linear
alkyl groups having an amino group, (5) cyclic alkyl groups, (6) phenyl groups, (7) azobenzene groups, and (8) cinnamic acid
groups;

(b) the one or more host groups are ?-cyclodextrins, and
the one or more guest groups are at least one member selected from the group consisting of (1?) t-butyl groups, (2?) adamanthyl
groups, (3?) aryl groups, (4?) aryl groups having a hydroxyl group, (5?) aryl groups having a carboxyl group, (6?) aryl groups
having an amino group, (7?) ferrocenyl groups, (8?) azobenzene groups, and (9?) dansyl groups; and

(c) the one or more host groups are ?-cyclodextrins, and
the one or more guest groups are at least one member selected from the group consisting of (1?) alkyl groups having 18 or
less carbon atoms, (2?) alkyl groups having a hydroxyl group and having 18 or less carbon atoms, (3?) alkyl groups having
a carboxyl group and having 18 or less carbon atoms, (4?) alkyl groups having an amino group and having 18 or less carbon
atoms, (5?) adamanthyl groups, (6?) groups having clusters of carbon atoms, (7?) dansyl groups having an aryl group, (8?)
ferrocenyl groups, and (9?) anthracenyl groups.

US Pat. No. 9,566,428

ARTIFICIAL SENSORY EPITHELIUM

Osaka University, Osaka ...

1. An artificial sensory epithelium to be embedded in a cochlea of a patient, comprising:
a piezoelectric film having a thin and long strip shape; and
multitude microelectrodes arranged on the piezoelectric film,
wherein the piezoelectric film is configured to be arranged along a basilar membrane of the cochlea such that a longitudinal
direction of the piezoelectric film accords with a longitudinal direction of a scala tympani of the cochlea and vibration
of a portion of the basilar membrane propagates to the piezoelectric film when sound wave coming from outside of the cochlea
vibrates the portion of the basilar membrane, the portion of the basilar membrane corresponding to a frequency of the sound
wave,

the piezoelectric film is configured to vibrate a portion of the piezoelectric film in association with the vibration of the
portion of the basilar membrane, the portion of the piezoelectric film corresponding to the portion of the basilar membrane,

the piezoelectric film is configured to induce minute voltage corresponding to strain caused by vibration of the portion of
the piezoelectric film, and

the multitude microelectrodes are each configured to provide electric stimuli by the minute voltage to spiral ganglion neurons
wherein the piezoelectric film vibrates in association with vibration of the basilar membrane without receiving influence
of sound wave in an audible frequency band of the patient.

US Pat. No. 9,662,386

ADJUVANT FOR MUCOSAL VACCINE

Osaka University, Osaka ...

1. A method of enhancing systemic and mucosal immune responses against a vaccine antigen in a subject, comprising administering
to the subject an adjuvant comprising a protein complex composed of hemagglutinin (HA) subcomponents HA1, HA 2, and HA3of
botulinum toxin in combination with the vaccine antigen, wherein the protein complex is composed of (i) a protein consisting of the
amino acid sequence as shown in SEQ ID NO : 1, (ii) a protein consisting of the amino acid sequence as shown in SEQ ID NO:
2 , and (iii) a protein consisting of the amino acid sequence as shown in SEQ ID NO : 3.

US Pat. No. 9,632,303

OPTICAL MICROSCOPE, AND AUTOFOCUS DEVICE FOR OPTICAL MICROSCOPE

Osaka University, Osaka ...

1. An optical microscope comprising:
an observation optical system capable of capturing, with an image pickup device, an optical image of an observation target
object that has been obtained with an objective lens, and sending out the optical image as an image signal; and

an autofocus device that adjusts a focal position of the objective lens based on autofocus light emitted from a focusing light
source so as to focus on the observation target object,

wherein a capturing period during which an image of the observation target object is captured and a non-capturing period during
which an image of the observation target object is not captured are repeated in the image pickup device,

the image pickup device captures a moving image of the observation target object by continuously obtaining captured images
during the capturing period, and

the autofocus light is emitted from the focusing light source during the non-capturing period.

US Pat. No. 9,617,613

METHOD FOR MANUFACTURING FERROUS MATERIAL

OSAKA UNIVERSITY, Suita-...

1. A method for manufacturing a ferrous material, comprising the steps of:
heating the base material of a ferrous material to an AC1 point or higher;

introducing an amount of a strain assuming that an Mf point is decreased to be less than a temperature for using the ferrous material; and

cooling the base material, on which the heating step and the strain introduction step have been carried out, to a temperature
that is higher than the Mf point at a cooling rate, so that a line extrapolated with a cooling curve intersects with a region where martensite is produced
in the base material on a continuous cooling transformation diagram; and

inspecting the microstructure of the base material where the cooling step has been carried out so that no austenite remains
in the base material, to identify at least one of martensite, ferrite and pearlite, wherein

when martensite has been produced, at least an amount of a strain is introduced into the base material in the strain introduction
step or an additive amount of an austenite stabilization element to the base material is increased; and

when either ferrite or pearlite has been produced, either a cooling rate in the cooling step or an additive amount of an element
that suppresses diffusion transformation to the base material, is increased.

US Pat. No. 10,104,753

OPTICAL WAVEGUIDE FORMING METHOD AND APPARATUS

OSAKA UNIVERSITY, Suita-...

1. An optical waveguide forming method of forming an optical waveguide using a gas-enclosed vessel that has an internal space in which a polyvalent ionizable gas is enclosed, a laser beam irradiation device that irradiates the internal space with a pulse laser beam, and a discharge circuit that causes a pulse current to flow in the gas-enclosed vessel, the optical waveguide forming method comprising:a first step of causing the pulse current to flow in the gas-enclosed vessel using the discharge circuit such that the internal space enters a plasma state;
a second step of forming a polyvalent ionization channel in the internal space and causing the polyvalent ionization channel to expand by an inverse pinch effect by irradiating the internal space in the plasma state with the pulse laser beam as a trigger laser beam from the laser beam irradiation device; and
a third step of increasing a current value of the pulse current flowing in the gas-enclosed vessel before or during the irradiation with the trigger laser beam.

US Pat. No. 10,046,122

INSUFFLATION SYSTEM

FUJIFILM Corporation, To...

1. An insufflation system configured to supply a predetermined gas into a body cavity of a subject, comprising:an automatic air supply conduit line configured to automatically supply a gas into the body cavity to maintain a predetermined pressure in the body cavity;
a manual air supply conduit line configured to supply a gas into the body cavity by a manual operation;
a selection operation member, wherein the selection operation member is formed with at least one operation switch, the automatic air supply conduit line and the manual air supply conduit line are alternately switched every time when the operation switch is pushed and operated; and
a control unit configured to perform a control in which gas supply via the automatic air supply conduit and gas supply via the manual air supply conduit are not simultaneously performed, wherein, when the control unit detects operation of the selection operation member while gas supply is performed via one of the automatic air supply conduit and the manual air supply conduit, the control unit causes another one of the automatic air supply conduit and the manual air supply conduit to be in a communication state and causes the one of the automatic air supply conduit and the manual air supply conduit to be in a disconnection state.

US Pat. No. 9,878,112

INSUFFLATION SYSTEM AND INSUFFLATION APPARATUS

FUJIFILM Corporation, To...

1. An insufflation system which insufflates a gas supplied from a gas supply source into a lumen of a living body, the insufflation
system comprising:
a first insufflation conduit through which the gas is automatically insufflated into the lumen;
a second insufflation conduit through which the gas is insufflated into the lumen in response to manual operation;
a pressure detecting device configured to detect a pressure inside the lumen;
a control device configured to control an insufflation flow rate of the gas insufflated through the first insufflation conduit,
based on a pressure difference between the pressure detected by the pressure detecting device and a preset set pressure, the
control device configured to alternately repeat an insufflation step of insufflating the gas through the first insufflation
conduit and a pressure detection step of stopping insufflating the gas and detecting the pressure inside the lumen by the
pressure detecting device;

a first flow rate restricting device configured to restrict the insufflation flow rate of the gas insufflated through the
first insufflation conduit; and

a second flow rate restricting device configured to restrict the insufflation flow rate of the gas insufflated through the
second insufflation conduit, wherein

when one cycle is defined as one repeating unit formed of the insufflation step and the pressure detection step, the first
flow rate restricting device sets an average flow rate per cycle of the gas insufflated through the first insufflation conduit
to be less than or equal to the insufflation flow rate of the gas insufflated through the second insufflation conduit that
is restricted by the second flow rate restricting device, even if a duty ratio of an insufflation time per cycle of the gas
insufflated through the first insufflation conduit becomes maximum.

US Pat. No. 9,632,247

TERAHERTZ-WAVE DEVICE AND TERAHETZ-WAVE INTEGRATED CIRCUITS

ROHM CO., LTD., Kyoto (J...

1. A terahertz-wave device comprising:
a two dimensional photonic crystal slab;
lattice points periodically arranged in the two dimensional photonic crystal slab, the lattice points configured to diffract
terahertz waves in photonic bandgap frequencies in photonic band structure of the two dimensional photonic crystal slab in
order to prevent the terahertz waves from existing in a plane of the two dimensional photonic crystal slab;

a two dimensional photonic crystal waveguide disposed in the two dimensional photonic crystal slab, the two dimensional photonic
crystal waveguide formed of a line defect of the lattice points; and

a diode device disposed in a trench formed in the two dimensional photonic crystal waveguide so that a top surface of the
diode device is formed at a height equal to or lower than a height of a surface of the two dimensional photonic crystal waveguide.

US Pat. No. 9,822,344

METHOD FOR CULTURING PLURIPOTENT STEM CELLS

Osaka University, Osaka ...

1. A method of culturing undifferentiated stem cells having pluripotency, the method comprising:
seeding stem cells having pluripotency on a surface to prepare a seeded stem cell culture,
adding to the seeded stem cell culture an effective amount of a substance comprising hemagglutinin (HA) of a neurotoxin complex
of Clostridium botulinum to prepare an undifferentiated stem cell culture, and

subculturing the undifferentiated stem cells from the undifferentiated stem cell culture.

US Pat. No. 9,805,944

METHOD OF MANUFACTURING SILICON CARBIDE SEMICONDUCTOR DEVICE

OSAKA UNIVERSITY, Suita-...

1. A method of manufacturing a silicon carbide semiconductor device, the method comprising the steps of:
introducing an impurity into a surface portion of a front surface of a semiconductor substrate that contains silicon carbide,
thereby forming an impurity region in the surface portion;

covering the front surface of the semiconductor substrate by an oxide film having a thickness of 1 nm or more, after the forming
step; and

activating the impurity in the impurity region by performing a heat treatment, with the oxide film covering the front surface
of the semiconductor substrate, at a temperature of 1500 degrees C. or higher in a gas atmosphere that includes oxygen.

US Pat. No. 9,801,850

ANTIBACTERIAL AGENT

OSAKA UNIVERSITY, Osaka ...

1. A method for inhibiting bacterial infection by S. aureus, the method comprising:
administering an epigallocatechin gallate derivative represented by the following chemical formula (1), an isomer thereof,
or a salt thereof, wherein the isomer is a tautomer, a stereoisomer or an optical isomer:


where:
R1 to R6 are each a hydrogen atom, halogen, sodium, potassium, or an acyl group and may be identical to or different from one another,

wherein the acyl group has the following chemical formula (2):
—C(O)R17  (2),

where R17 is a straight or branched, saturated or unsaturated hydrocarbon chain that includes a carbon number of 1 to 19, and may be
substituted with one or more substituents, wherein the one or more substituents are independently selected from the group
consisting of an alkyl group, amino group, an alkylamino group or a dialkylamino group,

wherein
at least one of R1 to R6 is the acyl group, where R17 of the acyl group of the at least one of R1 to R6 is an unsaturated hydrocarbon chain;

R12 and R14 are a hydrogen atom, halogen, sodium, or potassium and may be identical to or different from one another; and

R7 to R11, R13, R15, and R16 are each a hydrogen atom.

US Pat. No. 9,790,241

REAGENT FOR ENHANCING GENERATION OF CHEMICAL SPECIES

Toyo Goesi Co., Ltd., Ic...

1. A composition comprising:
a reagent and
a precursor,
wherein the reagent enhances the generation of a chemical species from the Precursor;
wherein the reagent generates an intermediate by a first exposure using a light the wavelength of which is shorter than or
equal to 15 nm;

wherein a product is formed from the intermediate by a first elimination and a second elimination;
wherein the product is excited by a second exposure using a light of which wavelength is longer than or equal to 300 nm;
wherein the reagent transmutes into the product acting as a photosensitizer or acts as an acid generation enhancer; and
wherein the reagent has a moiety represented by chemical Formula (I):

where:
each of M1 and M2 in chemical Formula (I) is a carbon atom;
at least one of A, B, and C in chemical Formula (I) is hydrogen and the rest of A, B, and C in chemical Formula (I) is aryl;
at least one of D and E in chemical Formula (I) is hydrogen and the rest of D and E in chemical Formula (I) is an aryl group;
and

F is selected from the group consisting of an organosilyl group, an organogermyl group, and an organotin group.
US Pat. No. 9,701,937

CARRIER FOR CULTIVATION OF CELLS

KOKEN CO., LTD., Toshima...

1. A collagen carrier used in cartilage cell cultivation, said collagen carrier having pores on a surface and in an inner
part thereof, a stress of 10-30 kPa at 10% load and is prepared by adding an atelocollagen to water to obtain a dispersion,
adjusting the collagen dispersion to have a collagen concentration of 80 mg/ml, and lyophilizing the collagen dispersion with
a chemical cross-linking agent.

US Pat. No. 10,080,556

RETRACTOR

TOKUSEN KOGYO CO., LTD., ...

1. A retractor for excluding an inside wall of a hollow organ or an organ in a body cavity, the retractor comprising:a rigid perforation tube having a tip at a distal end;
a developing body that is configured to be accommodated and extended with respect to the distal end of the perforation tube; and
a grip connected to respective proximal ends of the perforation tube and the developing body, wherein the developing body includes:
an excluding section configured by a movable wire and a plurality of fixing wires arranged at a periphery of the movable wire, and
an introducing tube extended from the excluding section, the movable wire being passed through the introducing tube; wherein:
a distal end of the movable wire and distal ends of the fixing wires are joined in the excluding section, and
the grip includes, in order from a distal end of the grip, a first grip portion, a second grip portion, and a third grip portion, wherein the excluding section is caused to extend from the tip of the perforation tube by moving the second grip portion and the third grip portion toward the first grip portion in a state where the excluding section is closed and accommodated in the perforation tube, and the excluding section is capable of being developed, by moving the third grip portion toward the distal end of the grip without moving the second grip portion in a state where the excluding section is closed and extended from the tip of the perforation tube.

US Pat. No. 10,039,541

RETRACTOR

TOKUSEN KOGYO CO., LTD., ...

1. A retractor for excluding an inside wall of a hollow organ or an organ in a body cavity, the retractor comprising:an accommodation tube;
a developing body that is configured to be accommodated and extended with respect to the accommodation tube; and
a grip connected to respective proximal ends of the accommodation tube and the developing body, wherein
the developing body includes
an excluding section configured by a movable wire and at least three fixing wires arranged at a periphery of the movable wire, and
an introducing tube extended from the excluding section, the movable wire being passed through the introducing tube;
a distal end of the movable wire and a distal end of the fixing wire are joined in the excluding section;
among developing angles formed between two adjacent fixing wires in the excluding section when the developing body is developed, one developing angle ?2 is greater than a remaining developing angle ?1; and
the developing angle ?2 is 90° to 240°.

US Pat. No. 10,001,441

MODIFICATION PROCESSING DEVICE, MODIFICATION MONITORING DEVICE AND MODIFICATION PROCESSING METHOD

SCREEN HOLDINGS CO., LTD....

1. A modification processing device for modifying a film by irradiating a semiconductor substrate with light, comprising:a light irradiation part for irradiating a semiconductor substrate with light for modifying said film;
an electromagnetic wave detection part for detecting the intensity of an electromagnetic wave including a millimeter wave or a terahertz wave radiated from said semiconductor substrate in response to the irradiation with light for modifying said film;
a modification determination part for determining the modification state of said film of said semiconductor substrate, based on changes generated due to modification of said film proceeded by the irradiation with said light in the intensity of said electromagnetic wave detected by said electromagnetic wave detection part; and
an irradiation control part for controlling the irradiation with light for modifying said film of said semiconductor substrate, based on a result of determination of said modification determination part.
US Pat. No. 9,758,765

MODIFIED LAMININ AND USE THEREOF

OSAKA UNIVERSITY, Osaka ...

1. A modified laminin having a cell-growth regulatory molecule bound to at least one site selected from the ? chain N-terminus,
the ? chain C-terminus, the ? chain N-terminus and the ? chain N-terminus of a heterotrimeric laminin fragment,
wherein the cell-growth regulatory molecule is a growth factor binding molecule,
wherein the laminin fragment is a laminin E8 fragment and has integrin binding activity,
wherein the growth factor binding molecule is one or more kinds selected from
(a) perlecan or a fragment having a perlecan growth factor binding domain thereof,
(b) agrin or a fragment having an agrin growth factor binding domain thereof,
(c) XVIII type collagen or a fragment having a XVIII type collagen growth factor binding domain thereof,
(d) syndecan or a fragment having a syndecan growth factor binding domain thereof,
(e) glypican or a fragment having a glypican growth factor binding domain thereof, and
(f) latent TGF-? binding protein or a fragment having a latent TGF-? binding protein growth factor binding domain thereof,
wherein the modified laminin is a chimeric molecule comprising the growth factor binding molecule and the laminin E8 fragment.

US Pat. No. 9,751,068

TARGET SUBSTANCE TRANSFER METHOD, CRYSTAL PRODUCTION METHOD, COMPOSITION PRODUCTION METHOD, AND TARGET SUBSTANCE TRANSFER DEVICE

Osaka University, Osaka ...

1. A method for transferring a target substance from a first phase to a second phase, the method comprising:
a phase approximation step of bringing the first phase and the second phase into close proximity; and
a bubble collapse step of forming a bubble in a vicinity of a boundary between the first phase and the second phase and then
causing the bubble to collapse,

wherein the first phase is a liquid phase and contains the target substance,
the second phase is a liquid phase or a gel phase, and
in the bubble collapse step, the bubble is formed by focusing a laser beam in the vicinity of the boundary between the first
phase and the second phase, and thereby the target substance is transferred from the first phase to the second phase.

US Pat. No. 10,160,792

PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF

STEMRIM INC., Osaka (JP)...

1. A method of stimulating migration of a cell, mobilizing a cell from bone marrow to peripheral blood, and/or regenerating a tissue, in the body of a subject, wherein said method comprises administering to the subject an effective amount of a substance of any one of (a) to (c) below;(a) a peptide consisting of a portion of an HMGB1 protein of SEQ ID NO:1 and having cell migration-stimulating activity;
(b) a cell secreting said peptide of (a); and
(c) a vector into which a DNA encoding said peptide of (a) is inserted, wherein said peptide has an activity of stimulating migration of a cell and said peptide consists of all or part of the amino acid sequence of positions 1 to 195 of SEQ ID NO:1.

US Pat. No. 10,004,915

TRANSCRANIAL MAGNETIC STIMULATION SYSTEM

Teijin Pharma Limited, T...

12. A transcranial magnetic stimulation system, comprising:magnetic field generating means comprising a coil, configured to generate a variable magnetic field to be applied to a certain part of a patient's head and a holder configured to hold the coil; and
recognizing means configured to recognize a specific portion of an ear of the patient as a predetermined reference, wherein
the magnetic field generating means and the recognizing means are further configured to be mounted to the patient's head by the holder, and are further configured such that aligning the recognizing means with respect to the predetermined reference sets the coil in a predetermined posture with respect to the certain part of the patient's head, wherein
the recognizing means further comprises a first imaging device configured to recognize a tragus as the specific portion of the ear,
the recognizing means further comprises a second imaging device, at an opposing side of the magnetic field generating means as compared to the first imaging device, configured to recognize another tragus of another ear of the patient, and
the recognizing means is further configured to determine that the magnetic field generating means is set in the predetermined posture by determining that the optical axes of the first and second imaging devices intersect respective ones of the tragus and the another tragus.

US Pat. No. 9,993,655

IMAGE DATA PROCESSING DEVICE AND TRANSCRANIAL MAGNETIC STIMULATION APPARATUS

OSAKA UNIVERSITY, Suita-...

1. A transcranial magnetic stimulation apparatus for applying magnetic stimulation to a specific portion within a patient's head using a magnetic-field generation means disposed outside the head, the apparatus comprising:the magnetic-field generation means which is capable of moving toward a predetermined treatment irradiation position and posture thereof according to an operation of the patient or a patient assistant;
a storage means which stores a three-dimensional MRI image of a patient's head that has been previously taken;
a three-dimensional appearance image generation means which generates a three-dimensional appearance image of the patient's head in an initial posture;
an image generation means which performs positional alignment between the three-dimensional MRI image and the three-dimensional appearance image, and generates a three-dimensional image of the patient's head after the positional alignment;
a means which stores patterns of face characteristics as templates of characteristic regions, the face characteristics being suitable for tracking and being characteristics in the generated three-dimensional appearance image of the patient's head in the initial posture;
an after-movement image generation means which generates, when the patient's head has been moved, a three-dimensional image of the patient's head after the movement;
a means which finds out characteristic points in a face image after the movement using the templates to obtain three-dimensional coordinates of the characteristic regions;
a means which detects changes of the posture from the initial posture using the characteristic regions in the face image in the initial posture and the characteristic regions in the face image after the movement;
a magnetic-field generation means image generation means which generates an image of the magnetic-field generation means that indicates a current position of the magnetic-field generation means operated so as to maintain a positional relation with a specific portion on the three-dimensional MRI image of the patient's head;
a display means which displays the three-dimensional image of the patient's head after the movement and the image of the magnetic-field generation means in one image; and
a means which stores position and posture information about the predetermined treatment irradiation position and posture of the magnetic-field generating means as target information, in relation to the three-dimensional image of the patient's head after the movement,
wherein the predetermined treatment irradiation position and posture of the magnetic-field generating means is indicated as a target on the display means, and wherein the means which stores patterns of face characteristics as templates of characteristic regions is configured to store the patterns of face characteristics as templates of characteristic regions without using any laser projectors.

US Pat. No. 9,848,817

GAS SUPPLY APPARATUS

FUJIFILM Corporation, To...

1. A gas supply apparatus comprising:
a gas supply conduit to supply a gas to a digestive tract inside a subject;
a pressure sensor which detects a pressure in the digestive tract via the gas supply conduit;
a solenoid proportional valve which regulate an amount of the gas supplied to the digestive tract via the gas supply conduit;
and

a control unit which control operation of the solenoid proportional valve, wherein
the control unit is configured to operate in:
a first gas supply mode which is a gas supply mode for endoscopy, in which the control unit controls the solenoid proportional
valve base on a detection result of the pressure sensor so that the pressure in the digestive tract becomes a set pressure;
and

a second gas supply mode which is a gas supply mode for the control unit being configured to estimate a capacity of the digestive
tract based on a pressure in the digestive tract before gas is supplied to inside of the digestive tract and a pressure in
the digestive tract after gas is supplied to inside of the digestive tract, and to execute diagnostic testing for functional
dyspepsia or irritable bowel syndrome, in which the control unit controls the solenoid proportional valve according to a capacity
of the digestive tract to supply a fixed amount of the gas into the digestive tract based on the estimated capacity of the
digestive tract, and

the control unit selectively switches between the first gas supply mode and the second gas supply mode.

US Pat. No. 9,839,701

AROMATIC AMINO ACID DERIVATIVE AND POSITRON EMISSION TOPOGRAPHY (PET) PROBE USING THE SAME

OSAKA UNIVERSITY, Osaka ...

1. A compound of formula (I):

wherein n is 0 or 1;
R1 is a nonradioactive halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, an optionally substituted phenyl group, a
C1-C6 alkylthio group, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group or a C7-C12 aralkyloxy group;

R2 is —(CH2)p—[O(CH2)q]r—X (wherein X is a fluorine atom, p is an integer of 1 to 6, q is an integer of 1 to 4, and r is an integer of 0 to 4);

—OR2 is at the 4 or 5 position of the benzene ring;

R3 is a hydrogen atom; and

R4 is a hydrogen atom or a C1-C6 alkyl group, or

a pharmaceutically acceptable salt thereof.

US Pat. No. 9,792,255

ELECTRONIC STATE CALCULATION METHOD, ELECTRONIC STATE CALCULATION DEVICE, AND RECORDING MEDIUM

OSAKA UNIVERSITY, Osaka ...

1. A method of calculating an electronic state of a material by using a calculation device, the method comprising:
setting a set containing, as elements, a plurality of operation models loaded in a memory of the calculation device by using
the calculation device, where each of the operation models provides an approximate solution to an exact solution of the electronic
state of the material;

determining, in order to specify all of the operation models, for each operation model, an effective Hamiltonian including
effective interactions that act on an electron system containing two or more electrons existing on a plurality of electron
orbitals, by using the calculation device;

determining, in a process of calculating a self-consistent solution of the effective Hamiltonian by using each of the operation
models in the set, an optimized operation model among a plurality of operation models that are close in distance in a space
obtained by introducing a distance to the set through a use of an absolute norm between electronic densities given by the
operation models, based on a quantum mechanical variational method while defining a direction in which the calculated self-consistent
solutions continuously change by using the calculation device;

evaluating, when the optimized operation model is successively updated, a variational energy of the electron system by the
self-consistent solution of the effective Hamiltonian by using the calculation device;

updating the optimized operation model by using the calculation device so that the evaluated variational energy approaches
an energy of the exact solution to be calculated and further, so that the variational energy forms a monotonically decreasing
convex function;

calculating the exact solution of the electronic state from one or a plurality of variational energy series by using the calculation
device, and

executing an operation of storing the calculated exact solution or a series of the variational energy that approaches the
exact solution in the memory by using the calculation device;

wherein among one or a plurality of series of the operation models that provide a series of the variational energy that approaches
the exact solution, the series that includes the following operation model is determined by the calculation device,

wherein the operation model provides a quantum phase shown by the electronic state, the quantum phase is equated with the
exact solution without occurring a phase transition, and the operation model attains the self-consistent solution of the effective
Hamiltonian by a minimum number of calculation steps, and

wherein all of the operation models which are contained in the set are defined to be those satisfying following conditions
(i) to (v),

(i) the operation models obey a variational principle of a quantum mechanics,
(ii) the series of the operation models is a coverging series with respect to a primary order parameter of the electron system,
where the primary order parameter is electron density,

(iii) the series has no phase transition point among the operation models in the series,
(iv) each of the operation models has a continuous modification path connecting to an exact quantum mechanical representation
of the material,

(v) without the phase transition point, each of the operation models connects to a higher-ranked model series where a lambda-modification
path defined by subtraction of a positive-definite functional from the exact quantum mechanical representation exists.

US Pat. No. 9,778,138

METHOD FOR MEASURING LIGHT PHYSICAL CONSTANTS AND DEVICE FOR ESTIMATING LIGHT PHYSICAL CONSTANTS

OSAKA UNIVERSITY, Osaka ...

1. A light physical constant measurement method for measuring distribution of light physical constants within an optical transmission
medium, the light physical constant measurement method comprising:
obtaining information indicating a power spectrum and a phase spectrum of an input optical signal of a plurality of intensities;
measuring, for each of the plurality of intensities of the input optical signal, a power spectrum of an output optical signal
that is output after the input optical signal of the plurality of intensities propagates within the optical transmission medium;

virtually dividing the optical transmission medium along a propagation direction to set a plurality of first segments;
estimating light physical constants of the plurality of first segments based on a result of a first propagation simulation
that uses a model in which the input optical signal of each of the plurality of intensities propagates sequentially through
the plurality of first segments;

combining adjacent first segments included in the plurality of first segments, based on the estimated light physical constants
of the plurality of first segments, to set a plurality of second segments;

estimating light physical constants of the plurality of second segments based on a result of a second propagation simulation
that uses a model in which the input optical signal of each of the plurality of intensities propagates sequentially through
the plurality of second segments; and

outputting the estimated light physical constants of the plurality of second segments as the distribution of the light physical
constants within the optical transmission medium,

wherein the first propagation simulation requires, as input, the obtained information indicating the power spectrum and the
phase spectrum of the input optical signal of the plurality of intensities, and the light physical constants of the plurality
of first segments, and outputs a power spectrum of the output optical signal as a simulation result,

in the estimating of light physical constants of the plurality of first segments, the light physical constants of the plurality
of first segments are searched for using an evaluation function of evaluating a difference between the measured power spectrum
of the output optical signal and the power spectrum of the output optical signal obtained as the result of the first propagation
simulation, to estimate the light physical constants of the plurality of first segments without using information indicating
a phase spectrum of the output optical signal,

the second propagation simulation requires, as input, the obtained information indicating the power spectrum and the phase
spectrum of the input optical signal of the plurality of intensities, and the light physical constants of the plurality of
second segments, and outputs a power spectrum of the output optical signal as a simulation result,

initial values of the light physical constants of the plurality of second segments are set in the second propagation simulation
using the estimated light physical constants of the plurality of first segments,

in the estimating of light physical constants of the plurality of second segments, the light physical constants of the plurality
of second segments are searched for using an evaluation function of evaluating a difference between the measured power spectrum
of the output optical signal and the power spectrum of the output optical signal obtained as the result of the second propagation
simulation, to estimate the light physical constants of the plurality of second segments, and

each of the light physical constants of the plurality of first segments and the light physical constants of the plurality
of second segments includes a dispersion parameter and a nonlinear optical constant.

US Pat. No. 9,783,548

PRODUCTION METHOD FOR EPOXY COMPOUND USING SOLID CATALYST

OSAKA UNIVERSITY, Osaka ...

1. A method for producing an epoxy compound comprising:
reacting a compound having a carbon-carbon double bond with hydrogen peroxide in the coexistence of the compound having a
carbon-carbon double bond, aqueous hydrogen peroxide, a powder of a solid catalyst support and a powder of a solid catalyst,

wherein the solid catalyst comprises an isopolyacid, and
the isopolyacid is produced from a catalyst raw material comprising (a) tungstic acid or a salt thereof and (b) a cationic
polymer.

US Pat. No. 9,778,257

AUTOANTIBODY DETECTION METHOD, METHOD FOR TESTING POSSIBILITY OF AUTOIMMUNE DISEASE CONTRACTION, AUTOANTIBODY DETECTION REAGENT, AND AUTOIMMUNE DISEASE TEST REAGENT

Osaka University, Osaka ...

1. A detection method for detecting an autoantibody, the detection method comprising the steps of:
causing a sample and an antigen reagent comprising a denatured protein presented by an MHC class II molecule to come into
contact with each other; and

detecting a complex of an autoantibody in the sample and the denatured protein in the antigen reagent,
wherein the denatured protein is a misfolded protein resulting from denaturation of folding in a correctly folded protein.

US Pat. No. 10,260,165

METHOD FOR MANUFACTURING NITRIDE CRYSTAL SUBSTRATE AND SUBSTRATE FOR CRYSTAL GROWTH

Osaka University, Suita-...

1. A method for manufacturing a nitride crystal substrate, comprising: arranging a plurality of seed crystal substrates made of a nitride crystal in a planar appearance, so that their main surfaces are parallel to each other and their lateral surfaces are in contact with each other; growing a first crystal film using a vapor-phase growth method on a surface of the plurality of seed crystal substrates arranged in the planar appearance, and preparing a combined substrate formed by combining the adjacent seed crystal substrates with each other by the first crystal film; growing a second crystal film using a liquid-phase growth method on a main surface of the combined substrate so as to be embedded in a groove that exists at a combined part of the seed crystal substrates, and preparing a substrate for crystal growth having a smoothened main surface, wherein a thickness of the second crystal film is set to a minimum necessary thickness to grow the smoothened main surface of the substrate for crystal growth by embedding the second crystal film in the groove; and growing a third crystal film using the vapor-phase growth method, on the smoothed main surface of the substrate for crystal growth.

US Pat. No. 10,095,081

LIQUID CRYSTAL ELEMENT, DEFLECTION ELEMENT, LIQUID CRYSTAL MODULE, AND ELECTRONIC DEVICE

OSAKA UNIVERSITY, Osaka ...

1. A liquid crystal element that refracts light exiting therefrom, the liquid crystal element comprising:a first electrode to which a first voltage is applied;
a second electrode to which a second voltage is applied, the second voltage being different from the first voltage;
an insulating layer that is an electrical insulator;
a resistive layer;
a liquid crystal layer containing liquid crystal;
a third electrode to which a third voltage is applied;
a first boundary layer that is an electrical insulator; and
a second boundary layer that faces the first boundary layer with the insulating layer therebetween, wherein
the insulating layer is located among the first electrode, the second electrode, and the resistive layer, and insulates the first electrode, the second electrode, and the resistive layer from one another,
the resistive layer has an electric resistivity higher than each of electric resistivities of the first electrode and the second electrode, and lower than an electric resistivity of the insulating layer,
the resistive layer and the liquid crystal layer are located between the insulating layer and the third electrode,
the resistive layer is located between the insulating layer and the liquid crystal layer,
the second boundary layer is a resistor having an electric resistivity higher than the electric resistivity of the resistive layer or an electrical insulator,
the first electrode and the second electrode constitute a unit electrode,
the unit electrode includes a plurality of unit electrodes,
a second electrode of one unit electrode of mutually adjacent unit electrodes among the plurality of unit electrodes is adjacent to a first electrode of the other unit electrode of the mutually adjacent unit electrodes,
the first boundary layer is located between the second electrode and the first electrode that are adjacent to each other,
the resistive layer includes a plurality of resistive layers corresponding to the plurality of unit electrodes, and
the second boundary layer is located between mutually adjacent resistive layers among the plurality of resistive layers.

US Pat. No. 10,026,612

METHOD FOR PRODUCING GROUP III NITRIDE CRYSTAL, GROUP III NITRIDE CRYSTAL, SEMICONDUCTOR DEVICE AND APPARATUS FOR PRODUCING GROUP III NITRIDE CRYSTAL

Osaka University, Osaka ...

1. A method of producing a Group III nitride crystal, the method comprising a step of:causing a Group III metal to react with an oxidizing agent and nitrogen-containing gas, wherein the Group III metal, oxidizing agent, and nitrogen-containing gas react in a vapor phase, thereby producing the Group III nitride crystal.

US Pat. No. 10,025,187

PHOTOSENSITIZATION CHEMICAL-AMPLIFICATION TYPE RESIST MATERIAL, METHOD FOR FORMING PATTERN USING SAME, SEMICONDUCTOR DEVICE, MASK FOR LITHOGRAPHY, AND TEMPLATE FOR NANOIMPRINTING

TOKYO ELECTRON LIMITED, ...

1. A photosensitization chemical-amplification type resist material used as a photosensitive resin composition in a lithography process including a pattern-exposure step of irradiating a predetermined site of a resist material film formed using the photosensitive resin composition with ionizing radiation or non-ionizing radiation having a wavelength of equal to or less than 400 nm, a flood-exposure step of irradiating the resist material film having undergone the pattern-exposure step with non-ionizing radiation having a wavelength which is longer than the wavelength of the non-ionizing radiation used in the pattern-exposure and is greater than 200 nm, a baking step of heating the resist material film having undergone the flood-exposure step, and a developing step of forming a resist pattern by bringing the resist material film having undergone the baking step into contact with a developer, the photosensitization chemical-amplification type resist material comprising:(1) a base component which makes a portion subjected to the pattern-exposure soluble or insoluble in the developer after the baking step; and
(2) a component generating a photosensitizer and an acid through exposure; and
(3) a photodecomposition-type scavenger as a first scavenger capturing an acid and a cation,
wherein the component (2) is the following component (a), contains any two components among the following components (a) to (c), or contains all of the following components (a) to (c),
(a) an acid-photosensitizer generator generating an acid and a photosensitizer, which absorbs non-ionizing radiation having a wavelength of greater than 200 nm, by being irradiated with ionizing radiation or non-ionizing radiation having a wavelength of equal to or less than 400 nm,
(b) a photosensitizer precursor becoming a photosensitizer, which absorbs non-ionizing radiation having a wavelength of greater than 200 nm, by being irradiated with ionizing radiation or non-ionizing radiation having a wavelength of equal to or less than 400 nm, and
(c) a photoacid generator generating an acid by being irradiated with ionizing radiation or non-ionizing radiation having a wavelength of equal to or less than 400 nm,
wherein the component (b) includes a ketal compound or an acetal compound represented by the following Formula (XXXVI),

wherein, in the Formula (XXXVI), each of R9 and R10 independently represents a hydrogen atom; a phenyl group; a naphthyl group; an anthracenyl group; an alkoxy group having 1 to 5 carbon atoms; an alkylthio group having 1 to 5 carbon atoms; a phenoxy group; a naphthoxy group; an anthracenoxy group; an amino group; an amide group; a linear, branched or cyclic and saturated or unsaturated hydrocarbon group having 1 to 30 carbon atoms; an alkoxy group having 1 to 5 carbon atoms substituted with a linear, branched or cyclic and saturated or unsaturated hydrocarbon group having 1 to 30 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, an amino group, an amide group, or a hydroxyl group; an alkylthio group having 1 to 5 carbon atoms substituted with a linear, branched or cyclic and saturated or unsaturated hydrocarbon group having 1 to 30 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, an amino group, an amide group, or a hydroxyl group; a phenoxy group substituted with an alkoxy group having 1 to 5 carbon atoms, a hydroxyl group, an amino group, an amide group, or an alkyl group having 1 to 5 carbon atoms; a phenyl group substituted with a linear, branched or cyclic and saturated or unsaturated hydrocarbon group having 1 to 30 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, an amino group, an amide group, or a hydroxyl group; a naphthoxy group substituted with an alkoxy group having 1 to 5 carbon atoms, an alkyl group having 1 to 5 carbon atoms, an amino group, an amide group, or a hydroxyl group; an anthracenoxy group substituted with an alkoxy group having 1 to 5 carbon atoms, an alkyl group having 1 to 5 carbon atoms, an amino group, an amide group, or a hydroxyl group; a linear, branched or cyclic and saturated or unsaturated hydrocarbon group having 1 to 30 carbon atoms substituted with an alkoxy group having 1 to 5 carbon atoms, a phenoxy group, a naphthoxy group, an anthracenoxy group, an amino group, an amide group, or a hydroxyl group; or a carbonyl group to which an alkyl group having 1 to 12 carbon atoms is bonded,
in the Formula (XXXVI), each of R23 and R24 independently represents a phenyl group; a linear, branched or cyclic and saturated or unsaturated hydrocarbon group having 1 to 30 carbon atoms; or a phenyl group substituted with a linear, branched or cyclic and saturated or unsaturated hydrocarbon group having 1 to 30 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, or a hydroxyl group,
in the Formula (XXXVI), R9 and R10 or R23 and R24 may form a cyclic structure through a single bond, a double bond, or a bond containing —CH2—, —O—, —S—, —SO2—, —SO2NH—, —C(?O)—, —C(?O)O—, —NHCO—, —NHC(?O)NH—, —CHRg—, —CRg2—, —NH—, or —NRg—; and Rg represents a phenyl group; a phenoxy group; a halogen atom; a linear, branched or cyclic and saturated or unsaturated hydrocarbon group having 1 to 30 carbon atoms; a phenoxy group substituted with an alkoxy group having 1 to 5 carbon atoms, a hydroxyl group, or an alkyl group having 1 to 5 carbon atoms; or a phenyl group substituted with a linear, branched or cyclic and saturated or unsaturated hydrocarbon group having 1 to 30 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, or a hydroxyl group.

US Pat. No. 10,014,738

MAGNETIC WAVE GEAR DEVICE

IHI CORPORATION, Tokyo (...

1. A magnetic wave gear device comprising:a first member, a second member, and a third member which are rotatable relative to one another around a rotation axis,
wherein the second member is disposed between the first and third members, and includes a plurality of magnetic material pieces disposed around the rotation axis,
wherein the first member includes a plurality of first permanent magnets facing the second member and disposed around the rotation axis, and
wherein the third member includes:
(i) a plurality of pole teeth facing the second member and disposed around the rotation axis, a coil being singly wound on each pole tooth, and portions of coils next to each other in a direction around the rotation axis being disposed between pole teeth next to each other in the direction, and
(ii) a plurality of second permanent magnets, each second permanent magnet being disposed between the pole teeth in the direction and being disposed between the second member and the portions of the coils in a radial direction, and magnetic poles of sides of the second permanent magnets facing the second member being the same pole.

US Pat. No. 9,935,419

OPTICAL FIBER DEVICE

MITSUBOSHI DIAMOND INDUST...

1. An optical fiber device comprising:a first fiber configured to guide light;
a second fiber having a first end on or from which light is incident or output and a second end at which an end surface of the second fiber is obliquely joined to a side surface of the first fiber; and
a heat dissipation member that is disposed so as to cover an entire circumference of a joint portion of the first fiber and the second fiber and that has a thermal conductivity equal to or greater than that of the first and second fibers and a property of transmitting the light that is guided by the first fiber and the second fiber.

US Pat. No. 9,891,338

ELECTRIC NEAR-FIELD PROBE, CONTROL SYSTEM FOR SAME, AND PIEZOELECTRIC CRYSTAL DETECTOR

OSAKA UNIVERSITY, Suita-...

1. An electric near-field probe comprising
a series resonance circuit comprising a capacitor constructed such that a space between two metal plates arranged in parallel
to each other is filled with a dielectric material or air and

an inductor constructed such that a lead wire is wound around a toroidal core, wherein the capacitor and the inductor are
connected in series so that the series resonance circuit has a predetermined resonance frequency,

an electric near-field originating from a leakage electric field from the capacitor generated when an alternating voltage
is applied to the series resonance circuit is transmitted to a piezoelectric crystal so that the piezoelectric crystal is
excited and, at the same time, a piezoelectric effect signal generated from the excited piezoelectric crystal is received
by the capacitor so that the piezoelectric effect signal is detected by the series resonance circuit.

US Pat. No. 9,872,825

PEPTIDE WITH ANTI-AGING EFFECT AND USE THEREOF

Osaka University, Osaka ...

1. A peptide consisting of the amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1), or a derivative or salt of the peptide,
wherein the derivative has a modification selected from C-terminal amidation or esterification, protection of an N-terminal
amino group with a protecting group, protection of a substituent on an amino acid side chain in the molecule with a protecting
group, a combination of C-terminal amidation or esterification and protection of an N-terminal amino group with a protecting
group, a combination of C-terminal amidation or esterification and protection of a substituent on an amino acid side chain
in the molecule with a protecting group, a combination of protection of an N-terminal amino group with a protecting group
and protection of a substituent on an amino acid side chain in the molecule with a protecting group, and a combination of
C-terminal amidation or esterification, protection of an N-terminal amino group with a protecting group and protection of
a substituent on an amino acid side chain in the molecule with a protecting group.

US Pat. No. 9,846,081

LIGHT WAVELENGTH MEASUREMENT METHOD AND LIGHT WAVELENGTH MEASUREMENT APPARATUS

OSAKA UNIVERSITY, Osaka ...

2. A light wavelength measurement apparatus that measures a wavelength of target light, the light wavelength measurement apparatus
comprising:
a dispersion device that disperses the target light into a plurality of beams which reach a plurality of positions, the plurality
of positions corresponding to the wavelength of the target light and being arranged at a beam interval different from a main-scale
interval between adjacent graduations of a main scale;

a measurement unit configured to measure the wavelength of the target light by using the beam interval that is an interval
between the plurality of the beams as a vernier scale for measuring the wavelength of the target light within a wavelength
range specified by the main scale; and

a first dispersion device configured to receive the target light and disperse the target light into a first beam which reaches
a position corresponding to the wavelength of the target light,

wherein the plurality of the beams are a plurality of second beams,
the dispersion device is a second dispersion device, and
the measurement unit is further configured to:
specify the wavelength range including the wavelength of the target light based on a positional relationship between the first
beam and the main scale; and

extract, from the plurality of the second beams, a second beam which reaches a position corresponding to a graduation of the
main scale, during the measure of the wavelength of the target light, the wavelength of the target light being measured within
the specified wavelength range.

US Pat. No. 9,834,859

METHOD FOR PRODUCING GROUP III NITRIDE CRYSTAL, GROUP III NITRIDE CRYSTAL, AND SEMICONDUCTOR DEVICE

OSAKA UNIVERSITY, Osaka ...

1. A method for producing a Group III nitride crystal, comprising:
a seed crystal selection step of selecting plural parts of previously-provided Group III nitride as seed crystals for generation
and growth of Group III nitride crystals;

a contact step of causing the surfaces of the seed crystals to be in contact with an alkali metal melt;
a crystal growth step of causing a Group III element and nitrogen to react with each other under a nitrogen-containing atmosphere
in the alkali metal melt to generate and grow Group III nitride crystals, wherein

the seed crystals are hexagonal crystals,
in the seed crystal selection step, the seed crystals are arranged so that a-axes or c-axes of the respective seed crystals
that are adjacent to each other almost coincide with each other, and the angle formed between the a-axes or the c-axes is
5° or less, and

in the crystal growth step, the plural Group III nitride crystals grown from the plural seed crystals by the growth of the
Group III nitride crystals are bound, wherein the dislocation density of the produced Group III nitride crystal is 1.0×104 cm?2 or less.

US Pat. No. 10,209,504

LIGHT DETECTING DEVICE AND LASER MICROSCOPE SYSTEM

OLYMPUS CORPORATION, Tok...

1. A light detecting device comprising:a light path branching unit that branches a single detection light path of observation light from a specimen, into a plurality of branched light paths;
a plurality of light detectors that are provided to the respective branched light paths branched by the light path branching unit and that include an SSPD or Geiger mode APD to detect the observation light; and
a signal generating unit that generates a single image signal in accordance with detection signals outputted from the plurality of light detectors.
US Pat. No. 10,190,117

DOUBLE-STRANDED ANTISENSE NUCLEIC ACID WITH EXON-SKIPPING EFFECT

National University Corpo...

1. A pharmaceutical composition for modulating exon skipping of a coding or non-coding RNA in a mammalian cell comprising:a double-stranded nucleic acid complex comprising:
a first nucleic acid strand annealed to a second nucleic acid strand, wherein:
the first nucleic acid strand comprises (i) 8 to 100 nucleotides independently selected from natural nucleotides, modified nucleotides, and nucleotide analogs, (ii) at least one region consisting of 2 or 3 consecutive natural DNA nucleotides, (iii) no regions that have greater than 3 consecutive natural DNA nucleotides, and (iv) a bridged nucleotide/DNA mixmer oligonucleotide; and wherein the first nucleic acid strand is a splice-switching oligonucleotide (SSO) and is capable of hybridizing to the coding or non-coding RNA inside of the mammalian cell; and
the second nucleic acid strand comprises nucleotides independently selected from natural RNA nucleotides, modified RNA nucleotides, and nucleotide analogs, and at least one region comprising consecutive natural RNA nucleotides,wherein the at least one region consisting of 2 or 3 consecutive natural DNA nucleotides of the first nucleic acid strand forms a heteroduplex with the at least one region comprising consecutive natural RNA nucleotides of the second nucleic acid strand.

US Pat. No. 10,025,190

SUBSTRATE TREATMENT SYSTEM

TOKYO ELECTRON LIMITED, ...

1. A substrate treatment system for treating a substrate, comprising:a treatment station in which a plurality of treatment apparatuses which treat the substrate are provided;
an interface station which directly or indirectly delivers the substrate between an exposure apparatus which is provided outside the substrate treatment system and performs exposure of patterns on a resist film on the substrate, and the substrate treatment system;
a light irradiation apparatus which performs post-exposure with one-shot exposure of an entire surface of the substrate using UV light on the resist film on the substrate after the exposure of patterns is performed and prior to treatment by the treatment apparatus; and
a post-exposure station which houses the light irradiation apparatus and is adjustable to a reduced pressure or inert gas atmosphere,
wherein the post-exposure station is connected to the exposure apparatus directly or indirectly via a space which is adjustable to a reduced pressure or inert gas atmosphere;
wherein the post-exposure station and the exposure apparatus are located in separate chambers; and
wherein the post-exposure station is provided between the exposure apparatus and the interface station.
US Pat. No. 10,000,554

MODIFIED LAMININ CONTAINING COLLAGEN BINDING MOLECULE AND USE THEREOF

OSAKA UNIVERSITY, Osaka ...

1. A modified laminin wherein at least one of the ? chain N-terminus, the ? chain N-terminus and the ? chain N-terminus of a heterotrimeric laminin E8 fragment is fused with a collagen binding molecule, wherein the heterotrimeric laminin E8 fragment has integrin binding activity, and wherein the collagen binding molecule is selected from the group consisting of:(a) fibronectin or a fragment having a collagen binding domain thereof,
(b) collagenase or a fragment having a collagen binding domain thereof,
(c) integrin ?1 chain or a fragment having a collagen binding domain thereof,
(d) integrin ?2 chain or a fragment having a collagen binding domain thereof,
(e) integrin ?10 chain or a fragment having a collagen binding domain thereof,
(f) integrin ?11 chain or a fragment having a collagen binding domain thereof,
(g) platelet glycoprotein VI or a fragment having a collagen binding domain thereof,
(h) discoidin domain receptor 1 or a fragment having a collagen binding domain thereof,
(i) discoidin domain receptor 2 or a fragment having a collagen binding domain thereof,
(l) mannose receptor or a fragment having a collagen binding domain thereof,
(k) phospholipase A2 receptor or a fragment having a collagen binding domain thereof,
(l) DEC205 or a fragment having a collagen binding domain thereof,
(m) Endol80 or a fragment having a collagen binding domain thereof,
(n) von Willebrand factor or a fragment having a collagen binding domain thereof,
(o) MMP-2 or a fragment having a collagen binding domain thereof,
(p) MMP-9 or a fragment having a collagen binding domain thereof,
(q) leukocyte-associated immunoglobulin-like receptor 1 or a fragment having a collagen binding domain thereof, and
(r) leukocyte-associated immunoglobulin-like receptor 2 or a fragment having a collagen binding domain thereof.
US Pat. No. 9,974,884

BONE REGENERATION AGENT

OSAKA UNIVERSITY, Osaka ...

1. A method for producing a bone regeneration agent, the bone regeneration agent comprising a cell aggregate comprising an inactivated cell construct, a mineral and an extracellular matrix, wherein the inactivated cell construct is derived from stem cells as a source material, wherein the stem cell is one or more types selected from the group consisting of an embryonic stem (ES) cell, an embryonic germ (EG) cell and an induced pluripotent stem (iPS) cell,the method comprising the steps of:
(a) inducing differentiation of the stem cells into mineral-producing cells in culture, wherein the culture is agitated at a frequency of 0.01 to 1.00 Hz to give the cell aggregate at least containing the mineral-producing cells, the mineral and the extracellular matrix, and
(b) inactivating the cell aggregate obtained in (a) wherein the cell aggregate is inactivated by one or more methods selected from the group consisting of lyophilization, freezing, heat treatment, high pressure treatment, acid solution treatment, alkali solution treatment, autoclave sterilization, radiation sterilization and gas sterilization.

US Pat. No. 9,965,849

VOID EVALUATION APPARATUS AND VOID EVALUATION METHOD IN THE SOLDER

OSAKA UNIVERSITY, Osaka ...

1. A void evaluation apparatus in a solder comprising:an evaluation function calculation unit for calculating a solder evaluation function by using a pixel value pi, contained in the voids, that is set to 1, and a pixel value pi not contained in the voids is 0 for each pixel constituting an image in the solder, and by using a weight function w(ri), which is maximum at a solder center (ri=0) and is 0 at a maximum radius (ri=r0) for a distance ri from the solder center; and
a void evaluation unit for evaluating that influence of voids is larger as the evaluation function is relatively larger for each solder, wherein the void evaluation unit uses the function:

to obtain images depicting indications of only voids having a relatively large effect, where i is a pixel number (1?N), pi is a pixel value (0 or 1), and w(ri) is the weighting function.
US Pat. No. 9,977,332

RESIST PATTERNING METHOD, LATENT RESIST IMAGE FORMING DEVICE, RESIST PATTERNING DEVICE, AND RESIST MATERIAL

OSAKA UNIVERSITY, Osaka ...

1. A resist patterning method comprising:forming a resist layer on a substrate, the resist layer including a resist composition containing a sensitizer precursor;
irradiating the resist layer with an activating energy beam to produce a sensitizer from the sensitizer precursor;
forming a latent pattern image in the resist layer by irradiating the resist layer containing the produced sensitizer with a latent image forming energy beam in a manner to cause the sensitizer to alternate between a non-excited state and an excited state of being excited by the latent image forming energy beam, to thereby form an acid; and
developing the resist layer having the latent pattern image formed therein.
US Pat. No. 9,970,003

METHOD OF TREATING PAIN WITH AN ANTIBODY AGAINST NETRIN-4, UNC5B OR NEOGENIN

OSAKA UNIVERSITY, Osaka ...

1. A method for the treatment of pain, comprising a step of administering, to a mammal, a therapeutically effective amount of an antibody against netrin-4, Unc5B or neogenin to treat pain in the mammal.