US Pat. No. 9,480,601

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

Optimedica Corporation, ...

1. A laser surgical system for making incisions in ocular tissues during a cataract surgical procedure, the system comprising:
a laser system comprising a scanning assembly;
a laser operable to generate a laser beam configured to incise ocular tissue;
an imaging device configured to acquire image data of at least a portion of the crystalline lens; and
a control system operably coupled to the laser system and configured to:
operate the imaging device to acquire image data;
identify one or more treatment targets based in part of the image data;
operate the scanning assembly to position a focal zone of the laser beam at a predetermined position in the ocular tissue;
prior to scanning the target tissue at the predetermined position, operate the imaging device to generate image data and process
the image data to determine whether the one or more treatment targets is located at the predetermined position; and

if the one or more targets is at the predetermined position, operate the laser and the scanning assembly to scan the focal
zone of the laser beam in a treatment scanning pattern, wherein positioning of the focal zone in the treatment scanning pattern
is determined in part by the control system based on the image data.

US Pat. No. 9,125,725

METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION

OPTIMEDICA CORPORATION, ...

1. A laser surgical system for making incisions in ocular tissues during a cataract surgical procedure, the system comprising:
a laser system comprising a scanning assembly, a laser operable to generate a laser beam configured to incise ocular tissue;
an imaging device configured to acquire point by point image data from locations distributed throughout a volume of a crystalline
lens of the patient and construct one or more images of the patient's eye tissues from the image data, wherein the one or
more images comprise an image of at least a portion of the crystalline lens; and

a control system operably coupled to the laser system and configured to:
operate the imaging device to generate image data for patient's crystalline lens;
process the image data to identify a location for each of one or more targets in the lens of the patient;
process the image data to determine a treatment scanning pattern for scanning a focal zone of the laser beam for performing
one or more incisions in the lens capsule; and

operate the laser and the scanning assembly to scan the focal zone of the laser beam in the treatment scanning pattern at
each location of the one or more targets, wherein positioning of the focal zone is guided by the control system based on the
location of the one or more targets so as to perform the one or more incision in the lens capsule.

US Pat. No. 9,351,879

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

OPTIMEDICA CORPORATION, ...

1. A system for intercoupling an ophthalmologic interventional system to an eye of a patient, comprising:
a. a hollow reservoir housing defining an interior volume and having proximal and distal ends, wherein the distal end comprises
a eye interface surface configured to be removably and sealably coupled to the eye of the patient, and wherein the proximal
end is configured to be mechanically interfaced with the interventional system in a manner that allows for open access to
the interior volume for transporting liquids or gases in or out of the interior volume;

b. an optical element fixedly coupled to the hollow reservoir housing and occupying a portion of the interior volume; and
c. a liquid layer formed within the interior volume of the reservoir housing and positioned, via one or more loads that include
gravitational loads, between the optical element and the eye,

wherein the eye interface surface comprises a compliant circumferential seal member, and the seal member comprises two circumferential
layers with a vacuum space interposed between the two layers.

US Pat. No. 9,237,967

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

OPTIMEDICA CORPORATION, ...

1. A system for ophthalmic intervention on an eye of a patient having temporary geometric markers thereon indicative of the
orientation of an astigmatic axis of the patient's eye, comprising:
a. an imaging device having a field of view oriented toward the eye of the patient;
b. a patient interface housing having proximal and distal ends and defining a passage therethrough, wherein the distal end
is coupled to one or more seals around a periphery of the passage configured to be directly engaged with an exterior surface
of the eye of the patient and having a size sufficient render visible the temporary geometric markers on the eye in that the
temporary geometric markers are within the field of view of the imaging device, and wherein the proximal end is configured
to be coupled to the patient workstation such that at least a portion of the field of view of the imaging device passes through
the passage;

c. two discrete, diametrically-opposed registration fiducials formed on an inner annulus of the patient interface housing
within the field of view of the imaging device such that they may be imaged by the imaging device in reference to the temporary
geometric markers on the eye of the patient;

d. a third registration fiducial formed on the inner annulus of the patient interface housing within the field of view of
the imaging device such that it may be imaged by the imaging device, the third registration fiducial being angularly spaced
from the two discrete, diametrically-opposed registration fiducials; and

e. control electronics operatively coupled with the image device and configured to process image data generated via the image
device for the registration fiducials and the temporary geometric markers on the eye of the patient so as to determine an
angular orientation of the eye relative to the patient interface housing, the control electronics further being configured
to determine an up or down orientation of the patient interface housing relative to the eye based on the location of the third
registration fiducial.

US Pat. No. 9,495,743

METHOD AND APPARATUS FOR AUTOMATED PLACEMENT OF SCANNED LASER CAPSULORHEXIS INCISIONS

Optimedica Corporation, ...

1. A method for locating a boundary of at least one anatomical structure of an eye of a patient comprising:
providing image information pertinent to at least one anatomical structure of the eye;
processing the image information to identify a first set of candidate edge locations for the at least one anatomical structure
of the eye, the first set of candidate edge locations being disposed in a first boundary surface portion of the at least one
anatomical structure,

using a least-squares technique to fit a first mathematical surface model to the first set of the candidate edge locations,
processing the image information based on proximity to the first mathematical surface model to identify a second set of candidate
edge locations for the at least one anatomical structure, the second set of candidate locations being disposed in a second
boundary surface portion of the at least one anatomical structure that is different from the first boundary surface portion,
and

using a least-squares technique to fit a second mathematical surface model to the combined first and second sets of candidate
edge locations; and

locating a boundary of the at least one anatomical feature based on the fit of the least-squares technique.

US Pat. No. 9,364,317

METHOD FOR CREATING INCISIONS TO IMPROVE INTRAOCULAR LENS PLACEMENT

OPTIMEDICA CORPORATION, ...

1. An intraocular lens assembly for positioning in a lens capsule of a patient's eye, consisting of:
a lens optic assembly including an optic portion and a surface surrounding a sidewall of the optic portion, the lens optic
assembly being shaped for positioning in a capsulorhexis incision in the patient's lens and focusing light passing therethrough,
wherein the optic portion comprises a lens;

exactly two spring haptics, each haptic being coupled to the lens optic assembly at a different juncture, each haptic comprising
a first end coupled to the lens optic assembly and second end disposed outward from and unconnected to the lens optic assembly,
the two spring haptics being shaped for supplying a spring force to the lens optic assembly within the lens capsule of the
patient's eye when the lens is implanted therein;

one and only one post and one and only one strut assembly, the post connected to the surface by the strut assembly and shaped
for positioning in a registration incision formed in the patient's lens capsule that is offset from the capsulorhexis incision,
thereby securing rotational orientation of the optic portion in the patient's eye, and

wherein the strut assembly is connected to the surface at a position different from each juncture.

US Pat. No. 9,095,415

METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION

OPTIMEDICA CORPORATION, ...

1. A method for incising ocular tissue during a cataract surgical procedure, the method comprising:
operating an imaging device to acquire image data of ocular tissue, the image data including lens interior image data for
an interior portion of the lens of a patient's eye;

processing the image data via a control system so as to generate an anterior capsulotomy scanning pattern for scanning a focal
zone of a laser beam for performing an anterior capsulotomy, the imaging device being operatively coupled to the control system;

generating the laser beam; and
scanning the focal zone of the laser beam in the anterior capsulotomy scanning pattern so as to perform the anterior capsulotomy,
wherein positioning of the focal zone is controlled by the control system based on the image data.

US Pat. No. 9,278,028

SYSTEM AND METHOD FOR PLASMA-MEDIATED MODIFICATION OF TISSUE

OPTIMEDICA CORPORATION, ...

1. A system for cataract surgery on an eye of a patient, comprising:
a. a first laser source configured to deliver a first laser beam in a pulsed form at a first pulse energy of between one-half
microjoule and 50 microjoules;

b. a second laser source configured to deliver a second laser beam in a pulsed form at a second pulse energy greater than
the first pulse energy, the second pulse energy being between 50 microjoules and 5,000 microjoules;

c. a scanning optical system, configured to:
i. receive the first and second laser beams; and
ii. adjust a first focus position of the first laser beam, and a second focus position of the second laser beam, in up to
three dimensions to direct the first and second laser beams onto one or more targeted tissue structure portions of the eye
of the patient;

d. a controller operatively coupled to the scanning optical system and configured to cause the scanning optical system to
scan the first focus position of the first laser beam in a first scanning pattern to photodisrupt a first tissue structure
portion with a plurality of pulses of the first laser beam to form an incised surface, and, subsequent to scanning the first
focus position of the first laser beam in the first scanning pattern, scan the second focus position of the second laser beam
in a second scanning pattern that is co-registered to the first scanning pattern to dispose the second focal position on the
incised surface for a plurality of pulses of the second laser beam to further photodisrupt the same first tissue structure
portion with the second laser beam to further separate segments of the first tissue structure along the incised surface wherein
the pulses of the first laser beam scanned in the first scanning pattern have a first pulse duration between 100 femtoseconds
and 10 picoseconds, and the pulses of the second laser beam scanned in the second scanning pattern have a second pulse duration
between 10 picoseconds and 10 nanoseconds and is longer than the first pulse duration.

US Pat. No. 9,271,870

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

OPTIMEDICA CORPORATION, ...

1. A method for cataract surgery on an eye of a patient using a pulsed laser surgical system, comprising:
operating an imaging system so as to acquire image data from locations distributed throughout a volume of a cataractous crystalline
lens of the patient and construct one or more images of the patient's eye tissues from the image data, wherein the one or
more images comprise an image of at least a portion of the crystalline lens;

identifying, using a computer system, an anterior capsulotomy cutting region based on the image data, the capsulotomy cutting
region comprising an anterior cutting boundary axially spaced from a posterior cutting boundary so as to define an axially-elongated
cutting zone transecting the anterior capsule; and

operating the surgical system to direct a pulsed laser treatment beam in a pattern based on the anterior capsulotomy cutting
region so as to create an anterior capsulotomy in the crystalline lens.

US Pat. No. 9,549,670

OPTICAL SURFACE IDENTIFICATION FOR LASER SURGERY

Optimedica Corporation, ...

1. A method of identifying optical surfaces in an eye for performing laser surgery on the eye, the eye including a cornea
having anterior and posterior surfaces, a lens capsule having anterior and posterior surfaces, an iris, and a limbus, the
method comprising:
coupling the eye to a laser eye surgery system that includes an optical coherence tomography (OCT) imaging subsystem, the
OCT imaging subsystem including a reference path length that is adjustable so that a distance from the laser eye surgery system
to a detection window of the OCT imaging subsystem is adjustable, the OCT imaging subsystem employing a detection beam having
a plurality of wavelengths such that the detection window spans a range of distances relative to the laser eye surgery system;

generating an OCT sample beam;
focusing the OCT sample beam at a plurality of different locations within the eye, the plurality of different locations include
at least two different distances from the laser eye surgery system, the different distances defining a depth range encompassing
an expected variability of distance from the laser eye surgery system to the corneal anterior surface, to the lens capsule
anterior surface, or the lens capsule posterior surface; and

processing returning portions of the sample beam focused at the plurality of different locations to locate, relative to the
laser eye surgery system, the corneal anterior surface, the lens capsule anterior surface, or the lens capsule posterior surface.

US Pat. No. 9,402,715

METHOD FOR PATTERNED PLASMA-MEDIATED MODIFICATION OF THE CRYSTALLINE LENS

Optimedica Corporation, ...

1. A method of treating a cataractous lens of a patient's eye, comprising:
a. generating a pulsed laser beam with a laser;
b. operating a scanning device to scan a focal point of the laser beam within the cataractous lens in a first treatment pattern
configured to create one or more incision surfaces that extend along a length between a posterior cutting limit and an anterior
cutting limit, the one or more incision surfaces being configured to bias the cataractous lens to fracture into sections;

c. operating the scanning device to scan the focal point in a second treatment pattern that creates softening cuts configured
to bias the sections to fracture into segments that are dimensionally smaller than the sections; and

d. splitting the cataractous lens into two or more sections wherein said softening cuts are produced by a lower pulse energy
than a pulse energy used to produce the incision surfaces.

US Pat. No. 9,101,448

METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION

OPTIMEDICA CORPORATION, ...

1. A laser surgical system for making incisions in ocular tissue during a cataract surgical procedure, the system comprising:
a laser system comprising a scanning assembly, a laser operable to generate a laser beam configured to incise ocular tissue,
and an imaging device; and

a control system operably coupled to the laser system and configured to:
operate the imaging device to generate image data for ocular tissue of a patient's eye, the image data including lens interior
image data for an interior portion of the lens of the patient's eye;

process the image data to determine an anterior capsulotomy scanning pattern for scanning a focal zone of the laser beam for
performing an anterior capsulotomy; and

operate the laser and the scanning assembly to scan the focal zone of the laser beam in the anterior capsulotomy scanning
pattern to perform the anterior capsulotomy,

wherein positioning of the focal zone is guided by the control system based on the image data.

US Pat. No. 9,233,024

METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS

OPTIMEDICA CORPORATION, ...

1. A cataract surgery method of treating target tissue in one or more of a cornea, limbus or sclera of a patient's eye, comprising:
generating a treatment light beam;
deflecting the treatment light beam using a scanner to form first and second treatment patterns;
delivering the first treatment pattern to a first target tissue selected from the group consisting of the cornea, limbus and
sclera of the patient's eye to form a cataract incision that is sized to provide access to an eye chamber of the patient's
eye for lens removal instrumentation; and

delivering the second treatment pattern to a second target tissue to form a relaxation incision along or near limbus tissue
or along corneal tissue anterior to the limbus tissue of the patient's eye to reduce astigmatism thereof,

wherein the incision formed by delivering the first treatment pattern only partially extends through the target tissue.

US Pat. No. 9,636,257

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

Optimedica Corporation, ...

1. A patient interface assembly for interfacing an ophthalmic intervention system with an eye of a patient, comprising:
a housing;
an optical lens coupled to the housing;
an eye engagement assembly coupled to the housing, the eye engagement assembly comprising an inner seal and an outer seal,
the eye engagement assembly adapted to be placed into contact with the eye of the patient by sealably engaging the eye with
the inner and outer seals, thereby defining a vacuum zone between the inner and outer seals when placed into contact with
the eye; and

a tissue migration bolster structure positioned between the inner seal and outer seal and configured to apply a resisting
load against portions of the eye in the vacuum zone which are capable of distending upon application of a vacuum load,

wherein one or more surfaces of the tissue migration bolster structure occupies a majority of a surface area defined between
the inner and outer seal.

US Pat. No. 9,474,649

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

OPTIMEDICA CORPORATION, ...

1. A laser surgical system for making incisions in ocular tissues during a cataract surgical procedure, the system comprising:
a laser operable to generate a laser beam for incising and imaging ocular tissue;
a scanning assembly operable to direct a focal zone of the laser beam to locations within a patient's eye;
an imaging device comprising a detector for detecting image data; and
a control system operably coupled to the laser, the scanning assembly, and the detector; the control system being configured
to:

operate the laser beam to generate image data for ocular tissue to be detected by the detector, the image data including lens
image data;

process the image data to determine an anterior capsulotomy scanning pattern for scanning the focal zone of the laser beam
for performing an anterior capsulotomy; and

operate the laser and the scanning assembly to scan the focal zone of the laser beam in the anterior capsulotomy scanning
pattern so as to perform the anterior capsulotomy, wherein positioning of the focal zone is guided by the control system based
on the image data.

US Pat. No. 9,233,023

METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS

OPTIMEDICA CORPORATION, ...

1. A cataract surgery scanning system for treating target tissue in one or more of a cornea, limbus or sclera of a patient's
eye, comprising:
a treatment light source for generating a treatment light beam;
a scanner for deflecting the light beam to form first and second treatment patterns of the treatment light beam under the
control of a controller; and

a delivery system comprising the controller operatively coupled to the treatment light source and the scanner, and programmed
to: (i) deliver the first treatment pattern to a first target tissue selected from the group consisting of the cornea, limbus
and sclera of the patient's eye to form a cataract incision therein that provides access to an eye chamber of the patient's
eye, the incision to be formed by delivering the first treatment pattern only partially extending through the target tissue,
and (ii) deliver the second treatment pattern to a second target tissue to form a relaxation incision along or near limbus
tissue, or along corneal tissue-of the patient's eye.

US Pat. No. 9,474,648

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

Optimedica Corporation, ...

1. A laser surgical system for making incisions in ocular tissues during a cataract surgical procedure, the system comprising:
a laser system comprising a scanning assembly;
a laser operable to generate a laser beam configured to incise ocular tissue;
an imaging device configured to acquire image data of at least a portion of the lens; and
a control system operably coupled to the laser system and configured to:
operate the imaging device to generate image data for the patient's crystalline lens;
process the image data to determine an anterior capsule incision scanning pattern for scanning a focal zone of the laser beam
for performing an anterior capsule incision; and

operate the laser and the scanning assembly to scan the focal zone of the laser beam in the anterior capsule incision scanning
pattern to perform the anterior capsule incision, wherein positioning of the focal zone is determined in part by the control
system based on the image data.

US Pat. No. 9,451,880

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

Optimedica Corporation, ...

1. A method for ophthalmic intervention on an eye of a patient having temporary geometric markers thereon indicative of the
orientation of axis of the patient's eye, comprising:
a. imaging a first and a second registration fiducial in reference to the temporary geometric markers on the eye of the patient,
the first and second registration fiducials being formed on an inner annulus of a patient interface housing within a field
of view of an imaging device;

d. imaging a third registration fiducial formed on the inner annulus of the patient interface housing within the field of
view of the imaging device such that it may be imaged by the imaging device, the third registration fiducial being angularly
spaced from both the first and second registration fiducials; and

c. processing image data generated via the image device for the first, second and third registration fiducials and the temporary
geometric markers on the eye of the patient so as to determine an angular orientation of the eye relative to the patient interface
housing and an up or down orientation of the patient interface housing relative to the eye based on the location of the third
registration fiducial.

US Pat. No. 9,445,946

LASER EYE SURGERY SYSTEM

Optimedica Corporation, ...

1. A laser eye surgery system, comprising:
a laser source configured to produce a treatment beam that includes a plurality of laser pulses;
a ranging subsystem configured to produce a source beam used to locate one or more structures of an eye, the ranging subsystem
includes an optical coherence tomography (OCT) pickoff assembly that includes a first optical wedge and a second optical wedge
separated from the first optical wedge, the (OCT) pickoff assembly being configured to divide the source beam into a sample
beam and a reference beam;

an integrated optical subsystem configured to receive the treatment beam, direct the treatment beam to selected treatment
locations within the eye so as to incise tissue at the selected treatment locations, receive the sample beam, direct the sample
beam to selected measurement locations within the eye, and transmit return portions of the sample beam from the selected measurement
locations back to the ranging subsystem for processing by the ranging subsystem; and

a patient interface assembly configured to couple the eye with the integrated optical subsystem so as to constrain the eye
relative to the integrated optical subsystem,

wherein:
each of the first and second optical wedges having non-parallel anterior and posterior surfaces;
the source beam propagates through the first optical wedge and into the second optical wedge;
the second optical wedge posterior surface is partially reflective so as to divide the source beam into a sample beam and
a reference beam;

the sample beam propagates out of the second optical wedge through the posterior surface;
the reference beam propagates out of the second optical wedge through the anterior surface and propagates back through the
first optical wedge and along a reference optical path;

the first and second optical wedges have a same wedge angle and are arranged such that the wedge angles are opposing; and
the OCT pickoff assembly is configured to have angles of incidence at all surfaces such that the OCT pickoff assembly is substantially
polarization insensitive.

US Pat. No. 9,119,703

METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION

OPTIMEDICA CORPORATION, ...

1. A laser surgical system for making incisions in ocular tissues during a cataract surgical procedure, the system comprising:
a laser system comprising a scanning assembly, a laser operable to generate a laser beam configured to incise ocular tissue;
an imaging device configured to acquire image data from locations distributed throughout a volume of a crystalline lens of
the patient and construct one or more images of the patient's eye tissues from the image data, wherein the one or more images
comprise an image of at least a portion of the crystalline lens; and

a control system operably coupled to the laser system and configured to:
operate the imaging device to generate image data for the patient's crystalline lens;
process the image data to determine an anterior capsule incision scanning pattern for scanning a focal zone of the laser beam
for performing an anterior capsule incision, wherein the anterior capsule incision is not in the form of a circle; and

operate the laser and the scanning assembly to scan the focal zone of the laser beam in the anterior capsule incision scanning
pattern to perform the anterior capsule incision, wherein positioning of the focal zone is guided by the control system based
on the image data.

US Pat. No. 9,119,704

METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION

OPTIMEDICA CORPORATION, ...

1. A laser surgical system for making incisions in ocular tissues during a cataract surgical procedure, the system comprising:
a laser system comprising one or more optical elements configured to produce a transverse focal volume that is transverse
to an optical axis, a scanning assembly, a laser operable to generate a laser beam configured to incise ocular tissue;

an imaging device configured to acquire image data from locations distributed throughout a volume of a lens of a patient and
construct one or more images of the patient's eye tissues from the image data, and

a control system operably coupled to the laser system and configured to:
operate the imaging device to generate image data for the patient's ocular tissue, including the lens;
process the image data to determine an incision scanning pattern for scanning the transverse focal zone of the laser beam
for performing an incision opening the lens capsule, and

operate the laser and the scanning assembly to scan the transverse focal zone of the laser beam to perform the incision, wherein
positioning of the transverse focal zone is guided by the control system based on the image data so as to perform the incision
opening the lens capsule.

US Pat. No. 9,750,640

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

Optimedica Corporation, ...

1. A system for surgery on an eye, comprising:
a. a pulsed laser configured to produce a treatment beam which creates dielectric breakdown in a focal zone of the treatment
beam within a sclera of the eye;

b. an imaging assembly capable of creating a continuous depth profile of the eye, the profile comprising information regarding
the location of the sclera, by detecting remitted illumination light from locations distributed throughout a volume of the
sclera, and generating signals based upon the remitted light;

c. an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions
in the sclera; and

d. one or more controllers operatively coupled to the laser, optical system, and imaging assembly, and programmed to automatically:
i. scan tissues of the patient's eye with the imaging assembly so as to generate image data signals to create a continuous
depth profile of the sclera;

ii. identify one or more boundaries of at least a portion of the sclera in the image data;
iii. identify one or more treatment regions based upon the boundaries; and
iv. operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the
one or more treatment regions so as to incise the sclera.

US Pat. No. 9,526,608

APPARATUS FOR CREATING INCISIONS TO IMPROVE INTRAOCULAR LENS PLACEMENT

OptiMedica Corporation, ...

1. An intraocular lens for replacing a natural lens in a lens capsule of a patient's eye, the intraocular lens comprising:
a lens portion configured to focus light passing therethrough;
at least two haptics extending from the lens portion for supplying a spring force to the lens portion within the lens capsule
when the lens is implanted therein; and

wherein the lens portion, not the at least two haptics, comprises a peripheral edge having a circular shape except in a region
having a registration feature radially extending from the peripheral edge, the registration feature configured to mate with
one or more complementary registration features created on the lens capsule so as to orient the intraocular lens, wherein
the intraocular lens comprises one and only one registration feature.

US Pat. No. 9,833,358

METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES

OPTIMEDICA CORPORATION, ...

11. A system for ophthalmic surgery of an eye of a patient, comprising:
a laser source, under the operative control of a controller, configured to alternatively deliver an ultraviolet treatment
laser beam and an ultraviolet probe laser beam, each laser beam comprising a plurality of ultraviolet laser pulses having
a wavelength between 320 nm and 400 nm, a pulse duration between 400 picoseconds and 700 picoseconds, and a pulse energy,
wherein the pulse energy of the ultraviolet probe laser beam is lower than the pulse energy of the ultraviolet treatment laser
beam;

an optical system operatively coupled to the laser source by the controller, the optical system having a numerical aperture
of 0.15 and a scan range of 6 mm to 10 mm in a direction lateral to a Z-axis aligned with the laser beam; and

an imaging system operatively coupled to the laser source and optical system by the controller,
wherein the controller is to operate the laser source, the optical system and imaging system to:
focus the ultraviolet treatment laser beam to a focal spot and direct the focal spot in a treatment scan pattern into the
one or more intraocular targets selected from the group consisting of a cornea, a limbus, a sclera, a lens capsule, a crystalline
lens, and a synthetic intraocular lens implant; and

direct the ultraviolet probe laser beam to the at least one or more intraocular targets and to confocally detect back reflected
light of the ultraviolet probe laser beam from the at least one or more intraocular targets, thereby obtaining image data
corresponding to the one or more intraocular targets,

wherein the treatment scan pattern creates one or more cuts in the one or more intraocular targets selected from the group
consisting of one or more corneal relaxing incisions, one or more limbal relaxing incisions, one or more astigmatic keratotomies,
one or more corneal flaps, one or more corneal transplant shapes, and one or more capsulotomies.

US Pat. No. 9,820,848

METHOD FOR CREATING INCISION TO IMPROVE INTRAOCULAR LENS PLACEMENT

Optimedica Corporation, ...

1. An intraocular lens for insertion into a patient's eye, the intraocular lens comprising:
a lens portion shaped for focusing light passing therethrough; and
a flange having a groove with a radially inner end located radially inward of a peripheral edge of the flange, the groove
configured to position and retain the flange within a capsulorhexis incision in the lens capsule of the patient's eye at a
rotational orientation with respect to a central optical axis of the lens portion,

wherein the radially inner end of the groove forms a closed and continuous asymmetric annular shape in a plane perpendicular
to the optical axis of the lens portion, wherein the closed and continuous asymmetric annular shape is one which, when rotated
around the optical axis of the lens portion, coincides with itself only after a 360° rotation.

US Pat. No. 9,693,903

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

Optimedica Corporation, ...

1. A laser surgical system for making incisions in ocular tissues during a cataract surgical procedure, the system comprising:
a laser system comprising a scanning assembly, a laser operable to generate a laser beam configured to incise ocular tissue;
an imaging device configured to acquire image data from locations distributed throughout a volume of a crystalline lens of
the patient and construct one or more images of the patient's eye tissues from the image data, wherein the one or more images
comprise an image of at least a portion of the crystalline lens; and

a control system operably coupled to the laser system and configured to:
operate the imaging device to generate image data of a continuous depth profile of the volume of the patient's crystalline
lens;

identify one or more boundaries of the one or more tissue structures of the crystalline lens based at least in part on the
image data;

process the image data to determine a lens fragmentation treatment region of the lens of the eye based at least in part upon
the one or more boundaries, the lens fragmentation treatment region comprising a posterior cutting boundary located anterior
to the posterior capsule of the lens;

process the image data to determine a lens fragmentation scanning pattern for scanning a focal zone of the laser beam for
performing lens fragmentation, the lens fragmentation pattern comprising a scanning pattern at a plurality of depths within
the lens fragmentation treatment region; and

operate the laser and the scanning assembly to scan the focal zone of the laser beam in the lens fragmentation scanning pattern
consecutively at each of the plurality of depths within the lens fragmentation treatment region,

wherein positioning of the focal zone is guided by the control system based on the image data.

US Pat. No. 9,662,198

METHOD FOR CREATING INCISIONS TO IMPROVE INTRAOCULAR LENS PLACEMENT

Optimedica Corporation, ...

1. An intraocular lens assembly for positioning in a lens capsule of a patient's eye, comprising:
a lens optic assembly including an optic portion and a surface surrounding a sidewall of the optic portion, the lens optic
assembly being shaped for positioning in a capsulorhexis incision in the patient's lens and focusing light passing therethrough,
wherein the optic portion comprises a lens having one and only one registration feature in a peripheral edge of the lens;

exactly two spring haptics, each haptic being coupled to the lens optic assembly at a different juncture, each haptic comprising
a first end coupled to the lens optic assembly and second end disposed outward from and unconnected to the lens optic assembly,
the two spring haptics being shaped for supplying a spring force to the lens optic assembly within the lens capsule of the
patient's eye when the lens is implanted therein

wherein the registration feature is a single protrusion that radially extends from the peripheral edge,
wherein the edge of the protrusion is round, and
wherein the lens is round except where the protrusion extends from the peripheral edge.

US Pat. No. 9,107,732

METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION

OPTIMEDICA CORPORATION, ...

1. A laser surgical system for making incisions in ocular tissue during a cataract surgical procedure, the system comprising:
a laser operable to generate a laser beam for incising ocular tissue;
a scanning assembly operable to direct a focal zone of the laser beam to locations within a patient's eye;
an optical coherence tomography (OCT) imaging device; and
a control system operably coupled to the laser, the scanning assembly, and the OCT imaging device; the control system being
configured to:

operate the OCT imaging device to generate image data for ocular tissue of the patient, the image data including lens interior
image data for an interior portion of the lens of the patient's eye;

process the image data to determine an anterior capsulotomy scanning pattern for scanning the focal zone of the laser beam
for performing an anterior capsulotomy; and

operate the laser and the scanning assembly to scan the focal zone of the laser beam in the anterior capsulotomy scanning
pattern so as to perform the anterior capsulotomy, wherein positioning of the focal zone is guided by the control system based
on the image data.

US Pat. No. 9,849,032

LASER EYE SURGERY SYSTEM

Optimedica Corporation, ...

1. A laser eye surgery system comprising:
an eye interface device configured to interface with an eye of a patient;
an objective lens;
a scanning assembly configured to support the objective lens and the eye interface device and to scan a focal point of a laser
beam to different target locations within the eye in x, y and z orthogonal directions;

a laser beam source configured to generate the laser beam for performing the laser eye surgery;
wherein the scanning assembly, the objective lens and the eye interface device are configured to rest together on the eye,
to freely move together relative to the laser beam source in the x, y and z directions and to follow together a corresponding
free movement of the patient in the x, y and z directions;

a free-floating mechanism that supports the scanning assembly and is configured to accommodate the free movement of the scanning
assembly relative to the laser beam source in a manner that maintains alignment in the x, y and z directions between the laser
beam and the target locations during the free movement, the free-floating mechanism including first and second beam deflection
devices configured to slide relative to one another in at least the z direction to vary a distance in the z direction between
the first and second beam deflection devices, the first and second beam deflection devices being external to the scanning
assembly and located on an optical path between the laser beam source and the scanning assembly, the first beam deflection
device arranged to receive the laser beam in a first direction and deflect it to a second direction, and the second beam deflection
device arranged to receive the laser beam in the second direction and deflect it to a third direction, wherein the second
direction is the z direction, and the first and third directions are the x or y direction, the second beam deflection device
arranged to receive a reflection of a portion of the laser beam from the focal point location propagating in a direction opposite
to the third direction and deflect it to a direction opposite to the second direction, the first beam deflection device being
disposed to receive the portion of the electromagnetic radiation beam propagating in the direction opposite to the second
direction and deflect it to a direction opposite to the first direction; and

a detection assembly configured to generate an intensity signal indicative of intensity of the reflection of the portion of
the laser beam.

US Pat. No. 9,782,253

METHOD FOR PATTERNED PLASMA-MEDIATED MODIFICATION OF THE CRYSTALLINE LENS

Optimedica Corporation, ...

1. A method of treating a cataractous lens of a patient's eye, comprising:
a. generating a light beam;
b. deflecting the light beam using a scanner to form a treatment pattern of the light beam;
c. delivering the treatment pattern to the lens of the patient's eye to create a plurality of cuts in the lens in the form
two or more different incision patterns within the lens to segment the lens tissue into a plurality of patterned pieces, the
incision patterns comprising:

a first incision pattern comprising a plurality of laser incision planes each extending along a first length between a posterior
and an anterior surface of the lens capsule, wherein the plurality of the incision planes of the first treatment pattern comprise
at least two crossing cut incision planes, each crossing cut incision plane being a line segment when viewed en face; and

a second incision pattern comprising one or more laser incisions, each extending along a first length between a posterior
and an anterior surface of the lens capsule; and

wherein a center point of each of the crossing cut incision planes is laterally shifted over a depth direction from the anterior
surface to the posterior surface, thereby creating inclined incision planes, and an intersection of at least two of the crossing
cut in planes is laterally shifted over the depth direction.

US Pat. No. 9,693,905

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

OptiMedica Corporation, ...

1. A laser surgical system for making incisions in ocular tissue during a surgical procedure, the system comprising:
a laser system comprising;
a laser operable to generate a pulsed laser beam configured to incise ocular tissue in a posterior pole of the eye, the pulsed
laser beam comprising a plurality of laser pulses;

a scanning assembly; and
an imaging device capable of creating a continuous depth profile of the eye, the profile comprising information regarding
the location of the one or more ocular tissues in the posterior pole; and

a control system operably coupled to the laser system and configured to:
operate the imaging device to acquire image data corresponding to a depth profile of the one or more ocular tissues in the
posterior pole;

identify one or more treatment regions in the posterior pole based upon the image data;
identify a location of one or more floaters based in part on the image data;
operate the scanning assembly to scan a focal zone of the laser beam in a treatment scanning pattern within the one or more
treatment regions at a predetermined position in the posterior pole,

each of the plurality of laser pulses scanned in the treatment scanning pattern sufficient to create a rupture zone in the
ocular tissue in the posterior pole;

wherein positioning of the focal zone in the treatment scanning pattern is determined in part by the control system based
on the image data.

US Pat. No. 9,642,748

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

Optimedica Corporation, ...

1. A method for ophthalmic intervention on an eye of a patient, comprising:
a. orienting a field of view of an imaging device toward the eye of the patient;
b. coupling a distal end of a patient interface housing to one or more seals configured to be directly engaged with one or
more surfaces of the eye of the patient, and coupling a proximal end of the patient interface housing to a patient workstation
such that at least a portion of the field of view of the imaging device passes through a passage of the patient housing defined
by the proximal and distal ends;

c. imaging, within the field of the view of the imaging device, three or more registration fiducials, which include first
and second registration fiducials coupled to the patient interface housing in a predetermined geometric configuration relative
to the patient interface housing in reference to predetermined geometric markers on the eye of the patient, which are also
imaged by the imaging device; and

d. processing imaging data generated via the imaging device so as to determine an angular orientation of the eye relative
to the patient interface based on the first and second fiducial and the predetermined geometric markers and also to determine
an up or down orientation of the patient interface housing relative to the eye based on the location of a third fiducial.

US Pat. No. 9,668,919

SYSTEM AND METHOD FOR PLASMA-MEDIATED MODIFICATION OF TISSUE

OPTIMEDICA CORPORATION, ...

1. A method for cataract surgery on an eye of a patient, comprising:
scanning a first focus position of a first pulsed laser beam at a first pulse energy of between one-half microjoule and 50
microjoules in a first scanning pattern to photodisrupt a first tissue structure portion with a plurality of pulses of the
first laser beam to form an incised surface; and

after scanning first focus position of the first laser beam in the first scanning pattern, scanning a second focus position
of a second pulsed laser beam having a second pulse energy being between 50 microjoules and 5,000 microjoules in a second
scanning pattern that is co-registered to the first scanning pattern to dispose the second focal position on the incised surface
for a plurality of pulses of the second laser beam to further photodisrupt the same first tissue structure portion with the
second laser beam to further separate segments of the first tissue structure along the incised surface,

wherein the pulses of the first laser beam scanned in the first scanning pattern have a first pulse duration between 100 femtoseconds
and 10 picoseconds, and the pulses of the second laser beam scanned in the second scanning pattern have a second pulse duration
between 10 picoseconds and 10 nanoseconds and is longer than the first pulse duration.

US Pat. No. 9,918,873

LASER EYE SURGERY SYSTEM CALIBRATION

OptiMedica Corporation, ...

1. A laser system to treat an eye with a laser beam, comprising:
a laser to generate the laser beam;
a tomography system to generate a measurement beam and measure at least one surface of the structure of the eye;
an optical delivery system coupled to the laser and the tomography system to deliver the laser beam and the measurement beam
to the eye;

a memory storing therein a look-up table, the look-table including first data which maps locations within the eye to one or
more control parameters for the laser, and further including second data which maps the locations within the eye to one or
more control parameters for the tomography system; and

a processor coupled to the laser, the tomography system, and the optical delivery system, the processor comprising a tangible
medium embodying instructions to:

in response to the first data in the look-up table, mark the eye at one or more mark locations corresponding to each of one
or more target locations, the one or more target locations being disposed at of one or more of a cornea, an aqueous humor,
an iris, an anterior lens capsule, an anterior lens capsule, a posterior lens capsule, a cortex, or a nucleus,

in response to the second data in the look-up table, measure with the measurement beam a measured location for each of the
one or more marks, and

compare the corresponding target location with the measured location for each of the one or more marks in order to determine
one or more of calibration of the laser system or eye position.

US Pat. No. 9,795,472

METHOD FOR CREATING INCISION TO IMPROVE INTRAOCULAR LENS PLACEMENT

Optimedica Corporation, ...

1. A system for treating a lesion on target eye tissue, comprising:
a. a light source for producing a laser beam;
b. one or more scanning elements configured to direct a focal point of a laser beam produced by the light source to various
portions of a lens capsule of an eye of a patient; and

c. a controller operatively coupled to the light source and to the one or more scanning elements, wherein the controller is
programmed to operate the one or more scanning elements to cause a laser beam produced by the light source to create a capsulotomy
and at least one intraocular lens registration feature within a lens capsule of a patient's eye,

wherein, taken together, the capsulotomy and the at least one registration feature has rotational asymmetry.

US Pat. No. 9,789,004

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

Optimedica Corporation, ...

1. A method for ophthalmic intervention on an eye of a patient having temporary geometric markers thereon indicative of the
orientation of an axis of the patient's eye, comprising:
a. imaging three or more registration fiducials in reference to the temporary geometric markers on the eye of the patient,
the registration fiducials being formed on an inner annulus of a patient interface housing within a field of view of an imaging
device capable of 3-dimensional imaging of the registration fiducials;

d. imaging the three or more registration fiducials formed on the inner annulus of the patient interface housing within the
field of view of the imaging device such that it may be imaged by the imaging device, and

c. processing image data generated via the imaging device for the three more registration fiducials and the temporary geometric
markers on the eye of the patient so as to determine a position, a pitch, a roll and a yaw of the patient interface device
relative to the geometric markers.

US Pat. No. 9,693,904

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

OptiMedica Corporation, ...

1. A laser surgical system for making incisions in ocular tissues during a cataract surgical procedure, the system comprising:
a laser system comprising a scanning assembly, a laser operable to generate a laser beam configured to incise ocular tissue;
an imaging device configured to acquire image data from locations distributed throughout a volume of a crystalline lens of
the patient and construct one or more images of the patient's eye tissues from the image data, wherein the one or more images
comprise an image of at least a portion of the crystalline lens; and

a control system operably coupled to the laser system and configured to:
operate the imaging device to generate image data of a continuous depth profile of the volume of the patient's crystalline
lens;

identify one or more boundaries of crystalline lens based at least in part on the image data;
process the image data to determine a lens fragmentation scanning pattern for scanning a focal zone of the laser beam for
performing lens fragmentation, the lens fragmentation scanning pattern comprising a planar pattern at a first depth and at
one or more additional depths anterior to the first depth;

process the image data to determine a lens fragmentation treatment region of the lens of the eye based at least in part upon
the one or more boundaries;

operate the laser and the scanning assembly to scan the focal zone of the laser beam within the lens fragmentation treatment
region in the planar pattern at the first depth and to subsequently direct the focal zone of the laser beam at the one or
more additional depths anterior to the first depth, thereby effecting patterned laser cutting of lens tissue,

wherein positioning of the focal zone is guided by the control system based on the image data.

US Pat. No. 9,968,486

PATIENT INTERFACE FOR OPTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

Optimedica Corporation, ...

1. A patient interface system for ophthalmic laser intervention on a patients eye, comprising:an upper portion having a generally cylindrical housing surrounding an aperture and further having a lower end, the upper portion further having an upper end adapted to couple to an ophthalmic laser surgery and imaging system, the upper portion further including an optical lens secured therein having a lower face and a focal axis co-axially aligned with the aperture;
a lower portion having a frustoconical housing of a first material surrounding an access aperture and a circular upper seal, the upper seal having two annular seal elements spaced apart to define an annular vacuum space therebetween, the lower portion further having a first set of vacuum lines for transmitting a source of vacuum to the vacuum space, wherein the lower end of the upper portion is sized and shaped to contact the two annular seal elements of the upper seal of the lower portion thus enabling releasable suction engagement of the lower portion to the upper portion when a vacuum is supplied to the vacuum space, the lower portion further having a circular lower seal of a material more flexible than the first material the circular lower seal being secured to a lower end of the frustoconical housing, the lower seal defining a pair of walls spaced apart and defining therebetween an annular vacuum chamber, the lower portion further having a second set of vacuum lines for transmitting the source of vacuum to the vacuum chamber thus enabling releasable suction engagement of the lower seal with a cornea and/or sclera when the vacuum is supplied to the vacuum chamber regardless of whether the upper portion is engaged with the lower portion; and
an annular tissue migration bolster ring of a metallic material less flexible than the lower seal material of the lower portion, and positioned between the pair of walls of the lower seal to prevent migration of tissue of the eye toward the patient interface system when a vacuum load is applied within the vacuum chamber,
wherein when the upper portion is engaged with the lower portion and the lower portion is engaged with the patient's eye, the aperture in the upper portion is co-axially aligned with the access aperture in the lower portion, the lower face of the optical lens is spaced from the eye and a liquid reservoir is defined between the patients eye, the lower face of the optical lens, and within the frustoconical housing of the lower portion such that when liquid fills the reservoir by gravity it provides an optical interface between the optical lens and the eye.

US Pat. No. 9,721,351

METHODS AND SYSTEMS FOR CORNEAL TOPOGRAPHY, BLINK DETECTION AND LASER EYE SURGERY

Optimedica Corporation, ...

1. A method of blink detection in a laser eye surgical system, comprising:
providing a topography measurement structure having at least one geometric marker;
placing the topography measurement structure into a position proximal to an eye of a patient such that light traveling from
the at least one geometric marker is capable of reflecting off a refractive structure of the eye of the patient;

detecting, with an image capture device, the light reflected from the eye of the patient for a predetermined time period while
the topography measurement structure is at the proximal position;

converting the light reflected from the surface of the eye in the predetermined time period into image data; and
analyzing the image data to determine whether light corresponding to the geometric marker is detected in the reflected light,
wherein if the geometric marker is determined not to be present, the patient is identified as having blinked during the predetermined
time.

US Pat. No. 9,895,263

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

Optimedica Corporation, ...

1. A method for ophthalmic intervention on an eye of a patient, comprising:
a) orienting a field of view of an imaging device toward the eye of the patient;
b) coupling a distal end of a patient interface housing to one or more surfaces of the eye of the patient, and coupling a
proximal end of the patient interface housing to a patient workstation such that at least a portion of the field of view of
the imaging device passes through a passage of the patient interface housing defined by the proximal and distal ends;

c) successively imaging, within the field of the view of the imaging device, one or more registration fiducials in reference
to predetermined geometric markers on the eye of the patient, which are also imaged by the imaging device, the one or more
registration fiducials being coupled to the patient interface housing in a predetermined geometric configuration relative
to the patient interface housing; and

d) processing successive imaging data generated via the imaging device so as to determine a successive position in X, Y, and
Z, together with a successive pitch, yaw, and roll of the patient interface housing.

US Pat. No. 9,849,033

LASER EYE SURGERY SYSTEM

Optimedica Corporation, ...

1. A laser eye surgery system comprising:
an eye interface device configured to interface with an eye of a patient;
an objective lens;
a scanning assembly configured to support the objective lens and the eye interface device and to scan a focal point of a first
and a second laser beam to different target locations within the eye in x, y and z orthogonal directions;

a laser beam source configured to generate the first and second laser beams for imaging the eye and performing the laser eye
surgery;

wherein the scanning assembly, the objective lens and the eye interface device are configured to rest together on the eye,
to freely move together relative to the laser beam source in the x, y and z directions and to follow together a corresponding
free movement of the patient in the x, y and z directions;

a free-floating mechanism that supports the scanning assembly and is configured to accommodate the free movement of the scanning
assembly relative to the laser beam source in a manner that maintains alignment in the x, y and z directions between the first
and second laser beams and the target locations during the free movement, the free-floating mechanism including first and
second beam deflection devices configured to slide relative to one another in at least the z direction to vary a distance
in the z direction between the first and second beam deflection devices, the first and second beam deflection devices being
external to the scanning assembly and located on an optical path between the laser beam source and the scanning assembly,
the first beam deflection device arranged to receive the first and second laser beams in a first direction and deflect it
to a second direction, and the second beam deflection device arranged to receive the laser beam in the second direction and
deflect it to a third direction, wherein the second direction is the z direction, and the first and third directions are the
x or y direction, the second beam deflection device arranged to receive a reflection of a portion of the first laser beam
from the focal point location propagating in a direction opposite to the third direction and deflect it to a direction opposite
to the second direction, the first beam deflection device being disposed to receive the portion of the electromagnetic radiation
beam propagating in the direction opposite to the second direction and deflect it to a direction opposite to the first direction;
and

a detection assembly configured to generate an intensity signal indicative of intensity of the reflection of the portion of
the first laser beam;

a controller configured to scan the focal point of the second laser beam within the eye to create a corneal or capsular incision
in the eye.

US Pat. No. 10,022,270

LASER CAPSULOVITREOTOMY

OPTIMEDICA CORPORATION, ...

1. A system for performing laser-assisted posterior capsulotomy that minimizes a risk of anterior hyaloid rupture to an eye having a lens capsule with a posterior surface, an anterior hyaloid surface, and a Berger's space between the posterior surface of the lens capsule and the anterior hyaloid surface, the system comprising:a laser source configured to produce a treatment beam comprising a plurality of laser pulses having a wavelength of 500 to 1100 nm, a pulse duration of 10 fs to 30 ns, a repetition rate of 10 Hz to 1 MHz, and an energy of 1 to 20 ?J;
an integrated optical system comprising an imaging assembly operatively coupled to a treatment laser delivery assembly, wherein the imaging assembly and the treatment laser delivery assembly share at least one common optical element, the integrated optical system being configured to image target tissue structures including the posterior surface of the lens capsule and the anterior hyaloid surface and direct a focal spot of the treatment beam in three-dimensional patterns, wherein the focal spot has a diameter of 1 to 20 microns; and
a controller operatively coupled with the laser source and the integrated optical system, the controller including a processor and a computer usable non-transitory medium having a computer readable program code embedded therein, the computer readable program code configured to cause the controller to identify the posterior surface of the lens capsule and the anterior hyaloid surface, and control the laser source and the integrated optical system cooperatively in sequence to:
direct the focal spot of the treatment beam within the Berger's space to form a layer pattern consisting of a plurality of bubbles which extend laterally within the Berger's space in directions transverse to an optical axis of the eye to increase a separation between the posterior surface of the lens capsule and the anterior hyaloid surface;
direct the focal spot of the treatment beam to the posterior surface of the capsule to incise the posterior surface of the lens capsule.

US Pat. No. 9,996,938

METHODS AND SYSTEMS FOR CORNEAL TOPOGRAPHY, BLINK DETECTION AND LASER EYE SURGERY

Optimedica Corporation, ...

1. A laser eye surgical system capable of blink detection, comprising:a topography measurement structure having at least one geometric marker, the topography measurement structure being configured to be placed into a position proximal to an eye of a patient such that light traveling from the at least one geometric marker is capable of reflecting off a refractive structure of the eye of the patient;
an image capture device configured to detect light reflected from the eye of the patient for a predetermined time period while the topography measurement structure is at the proximal position, and to convert the detected light into image data; and
control electronics coupled to the image capture device and configured to analyze the image data to determine whether light corresponding to the geometric marker is detected in the reflected light, wherein if the light corresponding to the geometric marker is determined not to be present, the control electronics identifies the patient as having blinked during the predetermined time.

US Pat. No. 9,987,165

LIQUID OPTICAL INTERFACE FOR LASER EYE SURGERY SYSTEM

Optimedica Corporation, ...

1. An apparatus to treat an eye, the apparatus comprising:a patient interface comprising,
an annular structure to engage an anterior surface of the eye, the annular structure comprising an opening to receive a portion of the eye and a channel to couple to the eye with suction, and
an optically transmissive structure to transmit light through the opening of the annular structure, wherein the optically transmissive structure and the annular structure define portions of an interface container when coupled to the eye, the interface container comprising an interface container volume;
a suction line coupled to the channel, configured to provide a suction pressure in the channel; and
a fluid collection container comprising an inlet, an outlet, and a fluid stop, the inlet coupled to the channel of the annular structure via the suction line, the fluid collection container comprising a collection volume greater than the interface container volume,
wherein the fluid stop is configured to pass gas and inhibit flow of a liquid or viscous material received from the fluid collection container, and
wherein the fluid collection container is configured to collect a fluid that has flown from the interface container into the channel and is drawn into the fluid collection container by the suction pressure.

US Pat. No. 10,105,261

AUTOMATED CALIBRATION OF LASER SYSTEM AND TOMOGRAPHY SYSTEM WITH FLUORESCENT IMAGING OF SCAN PATTERN

Optimedica Corporation, ...

1. A method of calibrating a laser surgical system with a three-dimensional treatment space, the laser surgical system comprising a laser system, a scanning system, and a camera under operative control of a controller, the laser surgical system further comprising a light source and an objective lens assembly, the method comprising:providing a mapping of sensor surface locations of a sensor surface to the three-dimensional treatment space of the laser system, the sensor surface included within the camera of the laser surgical system, including:
illuminating a calibration plate positioned at a known distance relative to the camera with illumination light from the light source, wherein the calibration plate has a plurality of through holes provided at discrete known locations in the three-dimensional treatment space, wherein a portion of the illumination light passes through at least some of the through holes to produce a plurality of light beams which impinge on the sensor surface at a plurality of positions of the sensor surface at a same time as each other,
viewing, using the camera, the calibration plate with the illumination light passing through the through holes which define the discrete known locations in the three-dimensional treatment space, and
removing out distortions of the camera based on the illumination light received by the camera from the discrete known locations defined by the through holes of the calibration plate;
scanning an electromagnetic radiation beam of the laser system, using the scanning system comprising an xy-scan device and z-scan device, each under the operative control of the controller, to a series of scanning locations of a fluorescent material disposed in the three-dimensional treatment space, the three-dimensional treatment space being located in front of the objective lens assembly which focuses the electromagnetic radiation beam from the scanning system to the scanning locations of the fluorescent material within the three-dimensional treatment space, the xy-scan device being responsive to xy-control parameters operable to scan the electromagnetic radiation beam orthogonally to a direction of propagation of the electromagnetic beam, and the z-scan device being responsive to one or more z-control parameters operable to vary a convergence depth of the electromagnetic beam in the direction of propagation;
capturing, either at the surface sensor of the camera or with a confocal detector, an emitted light from the series of scanning locations of the fluorescent material at a series of depth locations in the fluorescent material in response to the scanned electromagnetic radiation beam, after the emitted light has passed through the objective lens assembly;
calibrating the scanning system with the treatment space per the xy-control parameters, the z-control parameters, the captured emitted light from the series of scanning locations of the flouorescent material, and the mapping of the sensor surface locations to the treatment space, including
mapping the treatment space to the z-control parameters of the z-scan device, and
mapping the treatment space to the xy-control parameters of the xy-scan device,
thereby providing a calibrated laser surgical system.

US Pat. No. 10,004,639

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

OptiMedica Corporation, ...

1. A system for intercoupling an ophthalmologic interventional system to an eye of a patient, comprising:a. a hollow reservoir housing defining an interior volume and having proximal an distal ends, wherein the distal end comprises a eye interface surface configured to be removably and sealably coupled to the eye of the patient, and wherein the proximal end is configured to be mechanically interfaced with the interventional system in a manner that allows for open access to the interior volume for transporting liquids or gases in or out of the interior volume;
b. an optical element fixedly coupled to the hollow reservoir housing and occupying a portion of the interior volume; and
c. a liquid layer formed within the interior volume of the reservoir housing and positioned via one or more loads that include gravitational loads, between the optical element and the eye,
wherein the hollow reservoir comprises two parts that may be removably coupled to each other,
wherein the two parts are removably coupled to each other using a configuration selected from the group consisting of: a vacuum coupling interface, an interference fit interface, an electromagnetic coupling interface, and a electromechanically-actuated mechanical interface,
wherein the eye interface surface comprises a compliant circumferential seal member, and the seal member comprises two circumferential layers with a vacuum space interposed between the two layers.

US Pat. No. 9,968,439

METHOD FOR PATTERNED PLASMA-MEDIATED MODIFICATION OF THE CRYSTALLINE LENS

Optimedica Corporation, ...

1. A system for treating a cataractous lens of a patient's eye, comprising:a. a laser source for generating a light beam;
b. a scanning system for deflecting the light beam to form a treatment pattern of the light beam:
c. a controller operably coupled to the laser source and scanning system and configured to operate the scanner to form the treatment pattern comprising a plurality of cuts in the form an incision pattern for segmenting the lens tissue into a plurality of patterned pieces, the incision pattern consisting of: a cross shaped incision pattern having four rectangular cross bar quadrants, each cross bar quadrant being divided into subquadrants, as viewed from an anterior surface of the lens to a posterior surface of the lens and extending along a length between a posterior cutting limit within the lens and an anterior surface of the lens capsule.

US Pat. No. 9,987,166

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

Optimedica Corporation, ...

1. A system for ophthalmic intervention on an eye of a patient having temporary geometric markers thereon indicative of the orientation of an astigmatic axis of the patient's eye, comprising:a. an imaging device having a field of view oriented toward the eye of the patient, the imaging device configured for generating 3-dimensional images of the field of view;
b. a patient interface housing having proximal and distal ends and defining a passage therethrough, wherein the distal end is coupled to one or more seals around a periphery of the passage configured to be directly engaged with an exterior surface of the eye of the patient and having a size sufficient to render visible the temporary geometric markers on the eye in that the temporary geometric markers are within the field of view of the imaging device, and wherein the proximal end is configured to be coupled to the patient workstation such that at least a portion of the field of view of the imaging device passes through the passage;
c. three or more registration fiducials formed on an inner annulus of the patient interface housing within the field of view of the imaging device such that they may be imaged by the imaging device in reference to the temporary geometric markers on the eye of the patient;
d. control electronics operatively coupled with the image device and configured to process 3-dimensional image data generated via the image device for the three or more registration fiducials and the temporary geometric markers on the eye of the patient to determine a position, a pitch, a roll and a yaw of the patient interface device relative to the geometric markers.

US Pat. No. 9,901,503

MOBILE PATIENT BED

OPTIMEDICA CORPORATION, ...

1. A mobile patient bed for moving a patient between at least two locations during a medical procedure, the mobile patient
bed comprising:
a communication device configured to selectively couple the mobile patient bed to at least one medical system;
at least one processor configured to:
receive a medical system command via the communication device and process the medical system command when the mobile patient
bed is coupled to the at least one medical system;

receive and process a user command when the mobile patient bed is not coupled to the at least one medical system; and
refrain from processing the user command when the mobile patient bed is coupled to the at least one medical system;
a seat; and
a plurality of motors configured to position the seat along a first axis that is longitudinal with respect to the bed, a second
axis substantially perpendicular to the first axis, and a third axis substantially perpendicular to the first and second axes,
wherein the positioning of the seat along each axis is independent of the positioning of each other axis, respectively, and
wherein the positioning of the seat is performed in response to the processed medical system command or the processed user
command.

US Pat. No. 10,080,684

SYSTEM AND METHOD FOR LASER CORNEAL INCISIONS FOR KERATOPLASTY PROCEDURES

Optimedica Corporation, ...

1. An apparatus for treating an eye having a cornea, the apparatus comprising:a cornea profiling system configured to measure a profile of a posterior surface of the cornea;
a laser configured to generate a laser beam; and
a processor comprising a tangible medium coupled to the laser and configured to receive data from the cornea profiling system, the tangible medium embodying instructions to determine an incision profile based on the posterior surface of the cornea,
wherein the cornea profiling system is configured to identify folds of the posterior surface of the cornea and wherein the tangible medium comprises instructions to cause the processor to define the incision profile with folds similar to the posterior surface of the cornea to inhibit resection of lamella of the stroma of the cornea.

US Pat. No. 10,034,795

INTRAOCULAR LENS

OPTIMEDICA CORPORATION, ...

1. A method of performing laser surgery in a patient's eye, comprising:generating a light beam;
deflecting the light beam using a scanner to form an enclosed treatment pattern that is configured to form an enclosed capsulorhexis incision that includes a registration feature, wherein the registration feature is a notch in a periphery of the enclosed capsulorhexis incision, the enclosed capsulorhexis incision consisting of a smooth portion and the notch, wherein the notch has an outline which is smooth and which intersects with the smooth portion to form two defined corners;
delivering the enclosed treatment pattern to target tissue in the patient's eye to form in an anterior lens capsule of the patient's eye the enclosed capsulorhexis incision that includes the registration feature,
wherein the registration feature of the capsulorhexis incision is configured so that an edge of the target tissue formed by the enclosed capsulorhexis incision is capable of mating with an intraocular lens registration feature on an intraocular lens so as to rotationally register the intraocular lens relative to the registration feature.

US Pat. No. 10,123,696

CONFOCAL LASER EYE SURGERY SYSTEM

OPTIMEDICA CORPORATION, ...

6. An eye surgery system, comprising:an eye interface device configured to interface with an eye of a patient;
a scanning assembly mechanically coupled to the eye interface device and operable to scan a focal point of an electromagnetic radiation beam to different locations within the eye;
a light source configured to generate the electromagnetic radiation beam;
an optical path configured to propagate the electromagnetic radiation beam from the light source to the focal point and also configured to propagate a portion of the electromagnetic radiation beam reflected from the focal point location back along the optical path, the optical path comprising a first optical element disposed in the propagation path from the light source to the focal point,
the first optical element being configured to receive a first electromagnetic radiation beam, and to output a first portion which is less than 20% of the first electromagnetic radiation beam in a first direction toward the focal point and output a second portion of the first electromagnetic radiation beam in a second direction which is different from the first direction, the first optical element further configured to receive a second electromagnetic radiation beam from the focal point traveling in a third direction which is opposite the first direction, and to output a first portion which is greater than 80% of the second electromagnetic radiation beam to a fourth direction;
a detection assembly configured to receive the first portion of the second electromagnetic radiation beam that has been output by the beam-splitter to the fourth direction, and in response to the received first portion of the second electromagnetic radiation beam to generate an intensity signal indicative of an intensity of the received first portion of the second electromagnetic radiation beam reflected from the focal point location; and
a bypass assembly configured to be reversibly inserted into the optical path to divert the first electromagnetic radiation beam along a diversion optical path around the first optical element, the bypass assembly being configured to be moved to a first position in the optical path wherein the bypass assembly directs the first electromagnetic radiation beam to bypass the first optical element and delivers the first electromagnetic radiation beam to the eye of the patient at a treatment power level, and wherein the bypass assembly is further configured to be moved to a second position out of the optical path where the bypass assembly is out of beam paths that pass through the first optical element such that the first optical element delivers the first electromagnetic radiation beam to the eye of the patient at an imaging power level which is less than the treatment power level.

US Pat. No. 10,206,818

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

OPTIMEDICA CORPORATION, ...

1. A system for ophthalmic intervention on an eye of a patient, comprising:a. an imaging device having a field of view oriented toward the eye of the patient;
b. a patient interface housing having proximal and distal ends and defining a passage therethrough, wherein the distal end is coupled to one or more seals configured to be directly engaged with an exterior surface of the eye of the patient, and wherein the proximal end is configured to be coupled to a portion of the system such that at least a portion of the field of view of the imaging device passes through the passage;
c. two or more registration fiducials coupled to the patient interface housing in a predetermined geometric configuration relative to the patient interface housing within the field of view of the imaging device such that they may be imaged by the imaging device in reference to predetermined geometric markers on the eye of the patient which may also be imaged by the imaging device, wherein the two or more registration fiducials includes at least two registration fiducials either having different shapes or being made of different materials; and
d. control electronics operatively coupled with the image device and configured to process image data generated via the image device for the registration fiducials and the predetermined geometric markers on the eye of the patient so as to determine a position or orientation of the eye relative to the patient interface housing.

US Pat. No. 10,143,590

METHODS AND SYSTEMS FOR PERFORMING A POSTERIOR CAPSULOTOMY AND FOR LASER EYE SURGERY WITH A PENETRATED CORNEA

Optimedica Corporation, ...

1. A method for performing laser-assisted cataract surgery on an eye having a lens posterior capsule and an anterior hyaloid membrane, the method comprising:guiding a self-bent needle in a direction parallel to a lower surface of the lens posterior capsule to a space between the lens posterior capsule and the anterior hyaloid membrane;
injecting a fluid through the needle into the space between the lens posterior capsule and the anterior hyaloid membrane to separate the lens posterior capsule and the anterior hyaloid membrane;
after injecting the fluid, intra-operatively imaging at least a portion of the lens posterior capsule, thereby obtaining image data of a spatial disposition of an inverted lens posterior capsule; and
with the lens posterior capsule separated from the anterior hyaloid membrane, performing a posterior capsulotomy on the lens posterior capsule by using a laser to incise the lens posterior capsule based at least in part on the image data.

US Pat. No. 10,285,860

VACUUM LOSS DETECTION DURING LASER EYE SURGERY

OPTIMEDICA CORPORATION, ...

1. A method of detecting loss of vacuum in a patient interface of a laser eye surgery system, comprising:coupling a patient interface to the eye with suction provided to a suction ring in contact with the eye by a suction supply conduit so as to create an interface container over the eye defining an interface container volume, the suction supply conduit leading to a suction circuit having a source of suction;
introducing a liquid to the interface container volume to create a transmissive medium of the liquid above the eye;
coupling the patient interface to an ophthalmic laser surgery system;
performing an ophthalmic laser procedure on the eye through the patient interface while maintaining suction to the suction ring;
monitoring a supply suction pressure within the suction supply conduit;
measuring a monitoring conduit pressure in a monitoring conduit connected to sense pressure in the suction ring, the monitoring conduit leading to a monitoring circuit having a substantially smaller volume than the suction circuit; and
interrupting the ophthalmic procedure when the supply suction pressure or the monitoring conduit pressure rises above a threshold amount.

US Pat. No. 10,251,784

LASER EYE SURGERY SYSTEM CALIBRATION

OPTIMEDICA CORPORATION, ...

1. A method for treating an eye with a laser beam, comprising:providing a laser configured to generating the laser beam;
providing a tomography system configured to generate a measurement beam and measure at least one surface of a structure of the eye;
providing an optical delivery system coupled to the laser and the tomography system configured to deliver the laser beam and the measurement beam to the eye; and
storing in a memory a look-up table, the look-up table including first data which maps locations within the eye to one or more control parameters for the laser, and further including second data which maps the locations within the eye to one or more control parameters for the tomography system;
by a processor coupled to the memory, in response to the first data in the look-up table, controlling the laser and the optical delivery system to deliver the laser beam to the eye to mark the eye at one or more mark locations corresponding to each of one or more target locations, the one or more target locations being disposed at one or more of a cornea, an aqueous humor, an iris, an anterior lens capsule, an anterior lens capsule, a posterior lens capsule, a cortex, or a nucleus;
by the processor, in response to the second data in the look-up table, controlling the tomography system and the optical delivery system to measure with the measurement beam a measured location for each of the one or more marks;
comparing the corresponding target location with the measured location for each of the one or more marks to determine a system specific correction of the look-up table; and
by the processor, in response to the corrected look-up table, controlling the laser and the optical delivery system to deliver the laser beam to the eye to incise or treat the eye.

US Pat. No. 10,130,510

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

Optimedica Corporation, ...

1. A method for treating a floater in an eye of a patient, comprising:operating an imaging system so as to acquire image data from locations distributed throughout a volume of a posterior pole of the eye of the patient and construct one or more images of the patient's ocular tissue from the image data, wherein the one or more images comprise one or more boundaries of the floater in the ocular tissue;
constructing, using a computer system, a treatment region based on the one or more boundaries of the floater; and
operating a surgical system to direct a pulsed laser treatment beam in a treatment pattern based on the treatment region so as to dissect the ocular tissue, the pulsed laser treatment beam has a pulse repetition rate between about 1 kHz and about 1,000 kHz, and a pulse energy between about 1 microjoule and about 30 microjoules,
wherein the imaging system comprises one or more selected from the group consisting of an interferometer, a time domain optical coherence tomography system, a frequency domain optical coherence tomography system, a confocal microscope, and a scanning confocal microscope system.

US Pat. No. 10,085,886

METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES

OPTIMEDICA CORPORATION, ...

1. A system for ophthalmic surgery of an eye of a patient, comprising:a laser source configured to deliver an ultraviolet laser beam comprising a plurality of ultraviolet laser pulses having a wavelength between 320 nanometers and 370 nanometers to photodecompose one or more intraocular targets within the eye with chromophore absorbance, a pulse duration between 400 picoseconds and 700 picoseconds, and a pulse energy between 0.01 microJoules and 500 microJoules;
an optical system operatively coupled to the laser source and configured to focus the ultraviolet laser beam to a focal spot at a numerical aperture of less than 0.6 that provides for the focal spot of the laser beam to be scanned over a scan range of 6 mm to 10 mm in a direction lateral to a Z-axis that is aligned with the laser beam, wherein a diameter of the focal spot is between 0.5 microns and 10 microns within the one or more intraocular targets; and
a controller coupled to the laser source and the optical system, the controller being configured to operate the laser source and the optical system to:
direct the focal spot in a pattern into the one or more intraocular targets selected from the group consisting of a cornea, a limbus, a sclera, a lens capsule, a crystalline lens, and a synthetic intraocular lens implant; and
control the pulse energy, the pulse duration, and the focal spot of the laser beam such that an irradiance of the ultraviolet laser beam at the focal spot in the one or more intraocular targets is sufficient to produce linear absorption enhanced photodecomposition of the one or more intraocular targets with chromophore absorbance without exceeding a threshold of formation of a plasma and an associated cavitation event.

US Pat. No. 10,363,173

CONFOCAL DETECTION TO MINIMIZE CAPSULOTOMY OVERCUT WHILE DYNAMICALLY RUNNING ON THE CAPSULAR SURFACE

OPTIMEDICA CORPORATION, ...

1. A method of modifying an intraocular target of an eye, the method comprising:focusing a treatment beam to a focal point at a first location in the eye so as to therapeutically alter tissue at the first location;
measuring an intensity signal of electromagnetic radiation reflected from the first location in response to the treatment beam;
identifying a second location in the eye using the measured intensity signal of the electromagnetic radiation reflected from the first location;
scanning the focal point toward the second location and altering tissue at the second location with the treatment beam; and
repeating the measuring step and the identifying step for the second location and a plurality of additional locations in the eye, and repeating the scanning step and the altering step to alter tissue at the plurality of additional locations in the eye with the treatment beam, wherein the altering of the tissue at the first, second and the plurality of additional locations collectively form an incision surface in the eye.

US Pat. No. 10,292,863

INTERFACE FORCE FEEDBACK IN A LASER EYE SURGERY SYSTEM

OPTIMEDICA CORPORATION, ...

1. A laser eye surgery system, comprising:a patient support;
a patient interface assembly comprising a housing and a patient interface disposed within the housing so as to be vertically movable within the housing, wherein the patient interface is configured for coupling to an eye of a patient, the patient interface having an axis alignable with the eye of the patient, the patient interface comprising at least three force transducers to monitor forces between the eye of the patient and the patient interface and in response thereto to output force data; and
a controller which is configured to receive the force data from each of the force transducers and to ascertain therefrom: a first force between the eye of the patient and the patient interface along the axis of the patient interface, a second force between the eye of the patient and the patient interface in a first direction transverse to the axis and a third force between the eye of the patient and the patient interface in a second direction transverse to the axis, the controller being coupled to the patient support and further being configured to move the patient support along the axis and transverse to the axis in response to the ascertained forces,
wherein the controller embodies instructions of a program which is executed by the controller to move the patient support along the axis and in the first direction transverse to the axis and the second direction transverse to the axis in response to the ascertained forces so as to maintain each of the first, second, and third forces between the eye of the patient and the patient interface within a desired range.

US Pat. No. 10,195,017

METHOD FOR CREATING INCISION TO IMPROVE INTRAOCULAR LENS PLACEMENT

Optimedica Corporation, ...

1. A system for surgery on a tissue of a patient's eye, comprising:a. an imaging system for generating image data of one or more structures of the eye;
b. a light source for producing a laser beam;
c. one or more scanning elements for directing a focal point of a laser beam produced by the light source to various portions of a lens capsule of the eye; and
d. a controller operatively coupled to the imaging assembly, the light source and the one or more scanning elements, wherein the controller is programmed to operate the imaging system so as to acquire image data of the one or more structures of the eye, and operate the one or more scanning elements to guide a laser beam produced by the light source based at least in part on the image data to create a capsulotomy and at least one intraocular lens registration feature within the lens capsule of the eye, wherein, taken together, the capsulotomy and the at least one registration feature has rotational asymmetry.

US Pat. No. 10,327,953

LASER EYE SURGERY LENS FRAGMENTATION

OPTIMEDICA CORPORATION, ...

1. A method of generating a rotated lens fragmentation pattern for a lens of an eye, comprising:determining a spatial model of the eye in an eye coordinate reference system based on a measurement beam;
mapping the spatial model from the eye coordinate reference system to a machine coordinate reference system;
receiving a rotation angle of a corneal incision relative to a reference axis of the machine coordinate reference system;
determining a pre-rotated lens fragmentation pattern for the lens of the eye based on a plurality of laser fragmentation parameters;
determining a first rotation angle based on the rotation angle of the corneal incision and a rotation angle of the pre-rotated lens fragmentation pattern relative to the reference axis of the machine coordinate reference system;
rotating the spatial model by a negative of the first rotation angle;
rotating the pre-rotated lens fragmentation pattern and the spatial model by the first rotation angle such that the spatial model is aligned with the reference axis of the machine coordinate reference system and the rotated lens fragmentation pattern is aligned with the corneal incision; and
generating a laser beam by a laser source based on the rotated lens fragmentation pattern.

US Pat. No. 10,278,862

LOW VOLTAGE COMMUNICATION BETWEEN SUBSYSTEMS IN A LASER EYE SURGERY SYSTEM

OPTIMEDICA CORPORATION, ...

1. A laser eye surgery system, comprising:a first subsystem;
a processor; and
a first subsystem interface connected to the processor and connected to the first subsystem and configured for providing bidirectional communication with the first subsystem, the first subsystem interface including:
a first subsystem interface differential transmitter for transmitting a first differential signal to the first subsystem for controlling the first subsystem, and
a first subsystem interface differential receiver for receiving data from the first subsystem via a second differential signal separate from the first differential signal;
wherein the first subsystem comprises first subsystem control electronics in communication with the first subsystem interface, wherein the first subsystem control electronics includes:
a first subsystem differential receiver, separate from the first subsystem interface differential receiver, the first subsystem differential receiver having a load and being in communication with the first subsystem interface differential transmitter to receive from the first subsystem interface differential transmitter the first differential signal for controlling the first subsystem, and
a first subsystem differential transmitter, separate from the first subsystem interface differential receiver, the first subsystem differential transmitter being in communication with the first subsystem interface differential receiver for transmitting the data to the first subsystem interface differential receiver via the second differential signal.

US Pat. No. 10,195,085

VACUUM LOSS DETECTION DURING LASER EYE SURGERY

OPTIMEDICA CORPORATION, ...

1. A method of detecting loss of vacuum in a patient interface of a laser eye surgery system having control electronics, comprising:docking a patient's eye to a suction ring of the patient interface which is aligned with an optical axis of the laser eye surgery system;
monitoring a plurality of inputs associated with the docking, comprising:
a first input comprising a video feed of the laser eye surgery through the patient interface;
a second input comprising a physical force sensor that detects movement of the patient's eye relative to the patient interface; and
a third input comprising a vacuum sensor connected to a vacuum chamber of the suction ring; and
halting or delaying the laser eye surgery if an aggregate of the first, second, and third inputs is consistent with a threshold likelihood of a suction break.

US Pat. No. 10,376,356

METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS

Optimedica Corporation, ...

1. An optical beam scanning system for incising target tissue in a patient's eye, the optical beam scanning system comprising:a laser source configured to deliver a laser beam comprising a plurality of laser pulses, the laser beam being configured to produce optical breakdown and initiate a plasma-mediated process within the target tissue at a focal spot of the laser beam;
an Optical Coherence Tomography (OCT) imaging device configured to generate signals that can be used to create an image of eye tissue that includes the cornea of the patient's eye;
a delivery system for delivering the laser beam to the target tissue to form a cataract incision;
a scanner operable to scan the focal spot of the laser beam to different locations within the patient's eye; and
a controller operatively coupled to the laser source, the OCT imaging device and the scanner, the optical beam scanning, the controller programmed to:
scan the eye tissue with the OCT device to generate imaging data for the target tissue that includes imaging data for the cornea;
generate an incision pattern based at least in part on the imaging data, the incision pattern forming one or more relaxation incisions into the cornea, wherein each of the relaxation incision extends in an angular direction for a predetermined length less than a full circle, and wherein at least one of the one or more relaxation incisions is a partially penetrating incision that leaves an un-incised tissue thickness; and
scan the focal spot of the laser beam in the incision pattern, wherein the focal spot of the laser beam is guided based on the imaging data so that the focal spot of the laser beam is scanned from a posterior portion of the eye and proceeding anteriorly.

US Pat. No. 10,369,053

CORNEAL TOPOGRAPHY MEASUREMENTS AND FIDUCIAL MARK INCISIONS IN LASER SURGICAL PROCEDURES

OPTIMEDICA CORPORATION, ...

1. A laser cataract surgery system, comprising:a laser source configured to produce a treatment beam that includes a plurality of laser pulses;
a topography measurement system configured to measure a topography of the cornea of the eye;
an integrated optical system configured to receive and direct the treatment beam,
a processor in operable communication with the laser source, the topography measurement system, and the integrated optical system, wherein the processor is configured to control the laser cataract system to:
determine one of an axis, meridian and structure of an eye of a patient based on measurements produced by the topography measurement system, and
direct the treatment beam so as to incise one or more radial fiducial mark incisions in the cornea at the periphery of the eye and centered on one of a limbus, iris or scanned capsule of the eye, wherein the one or more radial fiducial mark incisions are disposed along the axis, meridian or structure.

US Pat. No. 10,357,399

CLOSED-LOOP LASER EYE SURGERY TREATMENT

OPTIMEDICA CORPORATION, ...

1. A method of treating an eye, comprising:measuring a first corneal topography of the eye;
determining a first curvature of the cornea based on the first corneal topography, and determining a target curvature of the cornea that treats the eye;
determining a first set of incisions in the cornea to achieve the target curvature of the cornea;
determining a first set of first partial incisions in the cornea, wherein the first partial incisions are smaller than the incisions of the first set of incisions;
performing the first set of first partial incisions on the cornea by a laser;
measuring a second corneal topography after performing the first set of first partial incisions;
determining a second curvature of the cornea based on the second corneal topography;
determining whether the second curvature differs from the target curvature by more than a threshold which indicates that the second curvature matches the target curvature;
when it is determined that the second curvature and the target curvature do not differ by more than the threshold, then ending treatment of the eye; and
when it is determined that the second curvature and the target curvature differ by more than the threshold, then:
determining a second set of incisions in the cornea different from the first set of incisions to achieve the target curvature in the cornea;
determining a second set of second partial incisions in the cornea, wherein the second incisions of the second set of partial incisions are smaller than the incisions of the second set of incisions; and
performing the second set of second partial incisions on the cornea by the laser.

US Pat. No. 10,314,479

LASER EYE SURGERY SYSTEM

OPTIMEDICA CORPORATION, ...

1. A ranging system configured to produce a source beam used to locate one or more structures of an eye, the ranging system including an optical coherence tomography (OCT) pickoff assembly for dividing an OCT light source beam into a sample beam and a reference beam, the OCT pickoff assembly comprising:a first optical wedge; and
a second optical wedge separated from the first optical wedge,
wherein:
the source beam propagates through the first optical wedge and into the second optical wedge;
each of the first and second optical wedges having non-parallel anterior and posterior surfaces with respect to entry and exit of the source beam as the source beam propagates through the first optical wedge and into the second optical wedge;
the second optical wedge posterior surface is partially reflective so as to divide the source beam into the sample beam and the reference beam;
the first and second optical wedges have a same wedge angle as each other and are arranged such that the wedge angles are opposing;
the sample beam propagates out of the second optical wedge through the posterior surface of the second optical wedge;
the reference beam propagates out of the second optical wedge through the anterior surface of the second optical wedge and propagates back through the first optical wedge and along a reference optical path;
the first and second optical wedges are separated by a distance greater than a detection range of the ranging system to inhibit etalon effects; and
angles of incidence at all surfaces of the first and second optical wedges are disposed such that the OCT pickoff assembly is substantially polarization insensitive.

US Pat. No. 10,314,746

LASER EYE SURGERY SYSTEM CALIBRATION

OPTIMEDICA CORPORATION, ...

1. An apparatus to treat an eye, the apparatus comprising:a pulsed laser to generate pulses of light energy;
an optical delivery system coupled to the laser;
a processor coupled to the pulsed laser and the optical delivery system, the processor configured to generate a treatment table having a plurality of columns including:
columns of input parameters comprising a plurality of three dimensional target locations of the eye, and
columns of output parameters comprising corresponding values of adjustable control parameters of the optical delivery system for directing the pulses of laser energy to the three dimensional target locations of the eye, and
wherein the processor is further configured to adjust the laser beam pulse energy at the plurality of three dimensional target locations of the eye in response to a look up table which maps the plurality of three dimensional target locations of the eye to a corresponding plurality of threshold amounts of laser beam energy to induce optical breakdown at the plurality of three dimensional target locations of the eye.

US Pat. No. 10,258,507

METHODS AND SYSTEMS FOR LASER SCAN LOCATION VERIFICATION AND LASER SURGICAL SYSTEMS WITH LASER SCAN LOCATION VERIFICATION

OPTIMEDICA CORPORATION, ...

1. A method of verifying the placement of a laser scan at a predetermined location within an eye, comprising:imaging at least a portion of the eye, the resulting image comprising the predetermined location;
identifying the predetermined location in the image, thereby establishing an expected scan location of the laser scan in the image;
performing the laser scan on the eye by scanning a focal point of a laser beam in a scanned area, the laser beam having a wavelength;
detecting a luminescence from eye tissue in the scanned area of the eye without receiving or detecting a reflected light from the eye tissue having a same wavelength as the wavelength of the laser beam, and identifying an actual scanned location within the image of the portion of the eye based on the detected luminescence; and
verifying whether the laser scan was at the predetermined location based on a difference between the actual scanned location in the image of the portion of the eye and expected scan location in the image of the portion of the eye.