US Pat. No. 9,340,792

RECOMBINANT LACTOBACILLUS WITH DECREASED LIPOTEICHOIC ACID TO REDUCE INFLAMMATORY RESPONSES

North Carolina State Univ...

1. A recombinant or isolated bacterium having been genetically modified to decrease the display of lipoteichoic acid (LTA)
on the surface of said bacterium, wherein the genetic modification comprises deletion or substitution of at least one base
pair such that the expression of at least one polynucleotide encoding a phosphoglycerol transferase is decreased,
wherein said polynucleotide encoding a phosphoglycerol transferase comprises a nucleotide sequence having at least 85% sequence
identity to the nucleic acid sequence as set forth in SEQ ID NO:1; and

wherein decreasing the expression of the at least one polynucleotide encoding a phosphoglycerol transferase decreases the
display of LTA on the surface of the bacterium.

US Pat. No. 9,655,917

IMMOBILIZATION OF AN ACTIVE AGENT ON A SUBSTRATE USING COMPOUNDS INCLUDING TRIHYDROXYPHENYL GROUPS

BAXTER INTERNATIONAL INC....

1. A method of immobilizing an active agent on a substrate, comprising the steps of:
providing a substrate with a surface, the substrate surface comprising a surface of a medical device or medical device component;
contacting the substrate with a solution of a compound including a trihydroxyphenyl group thereby coupling the trihydroxyphenyl
group to the substrate surface to provide a trihydroxyphenyl-treated substrate; and

contacting the trihydroxyphenyl-treated substrate with an active agent, thereby coupling the active agent to the compound
including a trihydroxyphenyl group and immobilizing the active agent on the substrate, and the compound including a trihydroxyphenyl
group is selected from the group consisting of gallic acid, phloroglucinol carboxylic acid, gallamide, benzenetriol, 5-methyl-benzene-1,2,3-triol,
3,4,5-trihydroxybenzaldehyde, 2,3,4-trihydroxybenzaldehyde, gallacetophenone, 3,4,5-trihydroxybenzamide, 2,3,4-trihydroxybenzoic
acid, 5-hydroxydopamine hydrochloride, methyl gallate, pyrogallol, derivatives thereof, salts of the foregoing, and combinations
thereof.

US Pat. No. 9,260,564

CATALYST FOR NON-ISOCYANATE BASED POLYURETHANE

Dow Global Technologies L...

1. A method for producing non-isocyanate based polyurethane, the method comprising:
providing a cyclic carbonate component, providing an amine component, and providing a cooperative catalyst component that
performs cyclic carbonate ring opening and includes an oxyphilic Lewis acid and an organic Lewis base, the Lewis acid being
a lithium salt that is lithium triflate or lithium tetrafluoroborate and the Lewis base being a cyclic amidine or a cyclic
guanidine.

US Pat. No. 9,711,728

FUSED THIOPHENE-BASED CONJUGATED POLYMERS AND THEIR USE IN OPTOELECTRONIC DEVICES

Northwestern University, ...

1. A polymer comprising as repeating units at least one annulated thienyl-vinylene-thienyl (TVT) unit and at least one other
pi-conjugated unit, wherein the annulated TVT unit is selected from the group consisting of:
wherein R1 and R2 independently are selected from the group consisting of H, halogen, CN, a C1-40 alkyl group, a C2-40 alkenyl group, and a C1-40 haloalkyl group; and
wherein the other pi-conjugated unit is a conjugated linear linker comprising one or more unsaturated bonds, or a conjugated
cyclic linker comprising one or more carbocyclic and/or heterocyclic rings.

US Pat. No. 9,119,712

MEDICAL DEVICES, SYSTEMS, AND KITS FOR THE MEDIALIZATION OF A VOCAL CORD

COOK MEDICAL TECHNOLOGIES...

1. A medical device comprising:
a proximal end and a distal end;
a proximal portion having an outer surface, an inner surface, and a first axial length, the inner surface defining a proximal
passageway extending through the proximal portion;

a distal portion having an outer surface, an inner surface, and a second axial length, the outer surface of the distal portion
defining an atraumatic distal tip, the inner surface of the distal portion defining a distal passageway extending through
the distal portion; and

an elongate body attached to and extending between the proximal portion and the distal portion, the elongate body having an
outer surface, an inner surface, and a third axial length, the outer surface of the elongate body defining a thread extending
from the proximal portion to the distal portion, the inner surface of the elongate body defining a main passageway in communication
with the proximal passageway and the distal passageway;

wherein the first axial length extends from the proximal end of the medical device to the elongate body, the second axial
length extends from the elongate body to the distal end of the medical device, and the third axial length extends from the
proximal portion to the distal portion; and

wherein the third axial length is greater than the first axial length and the second axial length.

US Pat. No. 9,442,095

OPTICAL COHERENCE PHOTOACOUSTIC MICROSCOPY

NORTHWESTERN UNIVERSITY, ...

1. An optical coherence photoacoustic microscope comprising:
a light source that outputs light of a single center wavelength;
a scanner that scans the output light of the single center wavelength across a sample by moving at least one of the sample
and the light relative to the other of the sample and the light;

a detector that receives reflected light from the sample in response to the scanned light;
a transducer positioned to detect photoacoustic waves induced in the sample by the scanned light; and
an image processing module that receives output from the transducer and the detector and that generates a photoacoustic microscopy
(PAM) image and an optical coherence tomography (OCT) image based on the received output.

US Pat. No. 9,150,534

PRODRUGS OF FLUORINATED MEVALONATES TO INHIBIT THE MEVALONATE PATHWAY OF STREPTOCOCCUS PNEUMONIAE

Northwestern University, ...

1. A compound of a formula

wherein X is selected from NH, O and S; R1 is selected from mono- and polyfluoro-substituted methyl moieties; and R2 is selected from alkyl, mono- and polyfluoro-substituted alkyl, alkanoyloxy, cycloalkyl, mono- and polyfluoro-substituted
cycloalkyl, aryl, mono- and polyfluoro-substituted aryl, arylalkyl, and mono- and polyfluoro-substituted arylalkyl moieties.

US Pat. No. 9,321,090

FORMING TOOLS HAVING TEXTURED SURFACES

FORD GLOBAL TECHNOLOGIES,...

1. A method of manufacturing metal-formed components having a desired shape, comprising the steps of:
contouring a surface of a forming tool for forming a metal blank into the desired shape, wherein respective portions of the
metal blank flow over the contoured surface during forming;

identifying an intrinsic material flow pattern imparted to the metal blank according to a uniform coefficient of resistance
for the contoured surface;

comparing the intrinsic material flow pattern to a desired flow in order to identify regions of the contoured surface having
an insufficient flow that creates areas in the formed metal blank receiving less than a desired amount of metal; and

applying a surface microtexture onto the contoured surface in a pattern selected to alter metal flow along the identified
regions by providing a reduced coefficient of friction in the identified regions relative to a coefficient of friction of
adjacent regions of the contoured surface;

wherein the step of applying a surface microtexture onto the contoured surface is comprised of laser etching of microscopic
dimples according to the pattern, wherein the dimples are formed as raised features above the contoured surface, and wherein
each dimple is in a range of about 5-10 ?m in length and about 3 ?m in height.

US Pat. No. 9,586,890

SCREENING METHODS FOR THE BINDING AFFINITY OF CHEMICAL ENTITIES TO BIOLOGICAL MOLECULES AND NEDD4-1 INHIBITORS IDENTIFIED BY THE SCREENING METHODS

Northwestern University, ...

1. A compound or a salt, ester, amide, or solvate thereof having a formula I:

wherein:
X is CH or N; Y is N, O, or S; Z is C or N;
R1 is selected from hydrogen, hydroxyl, thiol, halogen, alkoxy, alkylthio, amino, alkylamino, haloalkyl, and haloalkoxy;

R2, R3, and R4 are the same or different and are selected from hydrogen, halogen, and alkoxy;

R5 and R6 are the same or different and are selected from hydrogen, alkyl, cycloalkyl, aryl, and alkylaryl; and

R7 has a formula selected from:

wherein R8 is COR9, COOR, C(?O)NR2, C(?O)NHR, SO2R9 or CN, and R9 is selected from alkyl, aryl, alkoxy, amino, alkylamino, and anilino.

US Pat. No. 9,178,160

FUSED THIOPHENE-BASED CONJUGATED POLYMERS AND THEIR USE IN OPTOELECTRONIC DEVICES

Northwestern University, ...

1. A polymer comprising as repeating units at least one annulated thienyl-vinylene-thienyl (TVT) unit and at least one other
pi-conjugated unit, wherein the annulated TVT unit is represented by the formula:

wherein each of Cy1 and Cy2 is a five- or six-membered saturated carbocyclic ring, and the annulated TVT unit optionally is substituted and is covalently
linked to the other pi-conjugated unit via either the thiophene rings or Cy1 and Cy2; and

wherein the other pi-conjugated unit is a conjugated linear linker comprising one or more unsaturated bonds, or a conjugated
cyclic linker comprising one or more carbocyclic and/or heterocyclic rings.

US Pat. No. 9,666,805

BITHIOPHENE SULFONAMIDE-BASED MOLECULAR AND POLYMERIC SEMICONDUCTORS

Northwestern University, ...

1. A semiconducting compound comprising one or more optionally substituted bithiophene sulfonamide moieties, wherein the one
or more optionally substituted bithiophene sulfonamide moieties are identical or different, each being represented by formula
(I):

wherein:
R1 is selected from the group consisting of H, a C1-40 alkyl group, a C2-40 alkenyl group, a C2-40 alkynyl group, and a C1-40 haloalkyl group, each of which optionally is substituted with 1-10 substituents independently selected from a halogen, —CN,
NO2, OH, —NH2, —NH(C1-40 alkyl), N(C1-40 alkyl)2, —S(O)2OH, —CHO, —C(O)—C1-40 alkyl, —C(O)OH, —C(O)—OC1-40 alkyl, —C(O)NH2, —C(O)NH—C1-40 alkyl, —C(O)N(C1-40 alkyl)2, —OC1-40 alkyl, —SiH3, —SiH(C1-40 alkyl)2, —SiH2(C1-40 alkyl), —Si(C1-40 alkyl)3, —Si(C1-40 alkyl)2(—O—Si(C1-40 alkyl)3), —Si(C1-40 alkyl)(—O—Si(C1-40 alkyl)3)2, —Si(—O—Si(C1-40 alkyl)3)3, —O—SiH3, —O—SiH(C1-40 alkyl)2, —O—SiH2(C1-40 alkyl), —O—Si(C1-40 alkyl)3, —O—Si(C1-40 alkyl)2(—O—Si(C1-40 alkyl)3), and —O—Si(C1-40 alkyl)(—O—Si(C1-40 alkyl)3)2; and

R2 and R3 independently are selected from the group consisting of H, F, Cl, —CN, a C1-40 alkyl group, a C2-40 alkenyl group, a C2-40 alkynyl group, a C1-40 haloalkyl group, a C1-40 alkoxy group, and a C1-40 thioalkyl group, wherein each of the C1-40 alkyl group, the C2-40 alkenyl group, the C2-40 alkynyl group, the C1-40 haloalkyl group, the C1-40 alkoxy group, and the C1-40 thioalkyl group optionally is substituted with 1-5 substituents independently selected from a halogen, —CN, NO2, OH, —NH2, —NH(C1-6 alkyl), —N(C1-6 alkyl)2, —S(O)2OH, —CHO, —C(O)—C1-6 alkyl, —C(O)OH, —C(O)—OC1-6 alkyl, —C(O)NH2, —C(O)NH—C1-6 alkyl, —C(O)N(C1-6 alkyl)2, —OC1-6 alkyl, —SiH3, —SiH(C1-40 alkyl)2, —SiH2(C1-40 alkyl), —Si(C1-40 alkyl)3, —Si(C1-40 alkyl)2(—O—Si(C1-40 alkyl)3), —Si(C1-40 alkyl)(-O—Si(C1-40 alkyl)3)2, —Si(—O—Si(C1-40 alkyl)3)3, —O—SiH3, alkyl)2, —O—SiH2(C1-40 alkyl), —O—Si(C1-40 alkyl)3 alkyl)3), and —O—Si(C1-40 alkyl)(-O—Si(C1-40 alkyl)3)2.

US Pat. No. 9,301,927

PARA-XYLENE FILMS AND THERAPEUTIC USES THEREOF

Northwestern University, ...

1. An article of manufacture consisting essentially of: a polymer film with a top surface and a bottom surface,
wherein said polymer film consists essentially of a para-xylene polymer,
wherein said polymer film has a thickness between 1 ?m and 75 ?m,
wherein substantially all of said top surface has a water contact angle between 75 and 95 degrees and is non-adherent to tissue,
wherein substantially all of said bottom surface has a water contact angle between 75 and 95 degrees and is non-adherent to
tissue, and

wherein said polymer film is sterilized and sized to serve as a tissue separator and/or adhesion barrier in a subject.

US Pat. No. 9,092,737

SYSTEMS, METHODS, AND APPARATUS FOR 3-D SURFACE MAPPING, COMPLIANCE MAPPING, AND SPATIAL REGISTRATION WITH AN ARRAY OF CANTILEVERED TACTILE HAIR OR WHISKER SENSORS

NORTHWESTERN UNIVERSITY, ...

1. A method of determining surface topography of an object, the method comprising:
receiving a first set of moment and force input data from one or more identified topographies;
using a function approximator to receive a training data set based on the first set of moment and force input data from the
one or more identified topographies, wherein parameters to be used by the function approximator are modified via an evolutionary
algorithm that tests vectors of candidate parameters; and

receiving a second set of moment and force input data from an object surface and using the second set of data to provide a
surface mapping of the object, wherein the surface mapping comprises a spatial compliance map of the surface, wherein each
contact point in the mapping is to be associated with a compliance value represented as a rate of surface compression with
respect to a change in contact force.

US Pat. No. 9,051,583

MODIFIED SILICA SHELL PARTICLES, AND METHODS OF MAKING AND USING THE SAME

NORTHWESTERN UNIVERSITY, ...

1. A method comprising
a) admixing a nanoparticle and a silica reagent to form a silica shell nanoparticle;
b) admixing the silica shell nanoparticle and a biomolecule to attach the biomolecule to at least a portion of the silica
shell nanoparticle surface; and

c) at least partially removing the nanoparticle to form a biomolecule-surface modified silica shell particle.
US Pat. No. 9,055,765

DIETARY COMPOSITIONS AND RELATED METHODS OF USE

NORTHWESTERN UNIVERSITY, ...

1. A dietary composition comprising 2-4% by weight pectin, 2-5% by weight thickening agent, 0.5-4% by weight electrolyte component,
and water, wherein the dietary composition is a pudding.
US Pat. No. 9,605,054

COMPOSITION AND METHOD FOR TREATING A TAUOPATHY

The Board of Trustees of ...

1. A vaccine composition comprising a tau peptide consisting of SEQ ID NO:1 that stimulates production of an antibody that
binds Paired Helical Filament tau but does not bind non-denatured, soluble monomeric tau, wherein said tau peptide is in admixture
with an immunostimulatory adjuvant and said tau peptide is not post-translationally modified.

US Pat. No. 9,472,686

GATE-TUNABLE P-N HETEROJUNCTION DIODE, AND FABRICATION METHOD AND APPLICATION OF SAME

NORTHWESTERN UNIVERSITY, ...

1. A gate-tunable p-n junction diode, comprising:
a substrate;
a first semiconductor layer of molybdenum disulphide (MoS2) flakes having a first portion and a second portion extending from the first portion, formed on the substrate, the first
semiconductor layer having a first band gap being greater than 0 eV;

a second semiconductor layer of single-walled carbon nanotubes (SWCNTs) having a first portion and a second portion extending
from the first portion, formed on the substrate, such that the second portion of the first semiconductor layer of SWCNTs and
the second portion of the second semiconductor layer of MoS2 flakes are in directly contact and overlap with one another to define a vertically stacked heterojunction therewith, the second
semiconductor layer having a second band gap being greater than 0 eV; and

a first electrode and a second electrode formed on the substrate, being in contact with the first portion of the first semiconductor
layer of MoS2 flakes and the first portion of the second semiconductor layer of SWCNTs, respectively, such that the vertically stacked heterojunction
is located between the first electrode and the second electrode,

wherein the MoS2 flakes and SWCNTs are n-type and p-type semiconductors, respectively.

US Pat. No. 9,388,265

METHOD FOR PRODUCING SILYL-FUNCTIONALIZED POLYOLEFINS AND SILYL-FUNCTIONALIZED POLYOLEFINS WITH SILYL MONOMER INCORPORATION

DOW CORNING CORPORATION, ...

1. A method of producing a silyl-functionalized polyolefin comprising reacting a first functionalized olefin having the formula:
R?CH?CH—(Z)m—(CH2)nSiRaR?(3-a)
where Z is an electron withdrawing moiety, m is 0 or 1, n is an integer from 0-30, R is independently selected from the group
consisting of alkoxy group and amine group, a has a value in the range 1 to 3 inclusive; R? represents an hydrocarbyl group,
R? represents H or a group having an electron withdrawing effect or any other activation effect with respect to the —CH?CH—bond
or a moiety containing an aromatic ring or a C?C bond conjugated with the —CH?CH—with an ?-olefin having the general formula
CxH2x, where x is an integer between 1-30, in the presence of a catalytic amount of a group IV catalyst, wherein the group IV catalyst
comprises a group IV metallocene complex, for a time sufficient to produce a silyl-functionalized polyolefin, wherein the
first functionalized olefin is incorporated in the silyl-functionalized polyolefin in from about 0.1 to about 25 mole %, wherein
the group IV metallocene complex has the formula: [(C5Me5)2ZrMe][MeB(C6F5)3]; [(1,2—C5Me2H3)2ZrMe][MeB(C6F5)3]; or [(C5H5)2ZrMe][MeB(C6F5)3].

US Pat. No. 9,371,277

BENZAMIDE COMPOUNDS AND RELATED METHODS OF USE

Northwestern University, ...

1. A compound selected from compounds of a formula
wherein each of R1 and R2 is independently selected from phenyl, benzyl, heteroaryl, and heteroarylalkyl moieties; each of E1 and E2 is independently selected from CH and N, provided at least one of E1 and E2 is CH; A is a divalent moiety selected from carbonyl, amino, carboxamido (—C(O)NH—), imidocarbyl (—C(NH)—) and a tautomer
thereof (—N ?C(NH2)—) with X; X is a divalent moiety selected from methylene, carbonyl, amino, and aza-substituted ethylene (—NHCH2—) moieties; Y is a divalent moiety selected from oxy, amino, alkylene, and aza-substituted alkylene moieties; and Z is a
divalent moiety selected from sulfonyl, sulfinyl, thio, oxy, amino, and methylene moieties, providing where A is carbonyl,
Z is sulfonyl and R1 and R2 are selected from phenyl and substituted phenyl, X is not amino or methylamino and Y is not amino, alkylamino, allylamino
or benzylamino, and wherein each of R1, R2, A, X, Y and Z is optionally substituted with 1-10 substituents independently selected from halo, cyano, nitro, hydroxy,
amino, alkyl, cycloalkyl, cycloheteroalkyl, aryl, arylalkyl, alkoxy, alkenyl, haloalkyl, aminoalkyl, hydroxyalkyl, alkylene,
alkylsulfonyl, haloalkylsulfonyl, haloalkylsulfinyl, alkylamido, alkylsulfonamido, alkylthio, alkylcarbonyl, alkoxycarbonyl
and combinations of such substituents; R3 is selected from said substituents and combinations thereof; and n is an integer from 0-4, and salts of said compounds.

US Pat. No. 9,104,285

HAPTIC DEVICE WITH INDIRECT HAPTIC FEEDBACK

NORTHWESTERN UNIVERSITY, ...

1. A haptic device comprising: an indirect haptic device, comprising a substrate having a touch surface, a position sensor
that senses a position of a user's appendage relative to the touch surface, a friction modulator associated with the substrate,
a control device connected to the position sensor and the friction modulator, wherein a coefficient of friction on the touch
surface is modulated in response to a sensed position of a user's appendage relative to the touch surface and/or a derivative
thereof, and wherein the friction modulator does not alter the contour of the touch surface in a manner that is perceptible
to a user's sight or touch; and an actuator that moves the indirect haptic device relative to the user's appendage.

US Pat. No. 9,663,521

COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS

The United States of Amer...

1. A compound of formula (I):

wherein R1 is selected from the group consisting thioalkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, hydroxycycloalkyl, hydroxycycloalkylalkyl,
thiocycloalkyl, alkoxycycloalkyl, alkylthiocycloalkyl, dialkylaminoalkyl, heterocyclyl, heteroaryl, arylalkylpiperidin-4-yl,
arylpiperazinylalkyl, (tetrahydrofuran-3-yl)methyl, and (tetrahydrofuran-2-yl)methyl and (tetrahydro-2H-pyran-4-yl)methyl,

R2 is phenyl, optionally substituted with one or more substituents selected from the group consisting of halo, alkyl, hydroxyalkyl,
thioalkyl, alkoxy, alkylthioalkyl, alkoxycarbonyl, alkylthiocarbonyl, amino, alkylamino, dialkylamino, and alkylcarbonyl,

R3 is phenyl, optionally substituted with one or more substituents selected from the group consisting of halo, alkyl, hydroxyalkyl,
thioalkyl, alkoxy, alkylthioalkyl, alkoxycarbonyl, alkylthiocarbonyl, amino, alkylamino, dialkylamino, and alkylcarbonyl,

R4 is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, and arylalkyl,

or a pharmaceutically acceptable salt thereof,
wherein R4 is optionally substituted on the aryl and/or alkyl portion with one or more substituents selected from the group consisting
of halo, alkyl, hydroxyalkyl, thioalkyl, alkylthioalkyl, alkoxycarbonyl, alkylthiocarbonyl, amino, alkylamino, dialkylamino,
aminosulfonyl, hydroxyl, perfluoroalkoxy, alkylenedioxy, and alkylcarbonyl.

US Pat. No. 9,472,764

CONJUGATED POLYMERS AND THEIR USE IN OPTOELECTRONIC DEVICES

Northwestern University, ...

1. An organic photovoltaic device comprising an anode, a cathode, and in between the anode and the cathode a photoactive layer,
the photoactive layer comprising an electron-donor compound and an electron-acceptor compound, wherein the electron-donor
compound is a polymer of the formula:
wherein
R1 is selected from the group consisting of a C1-40 alkyl group, a C2-40 alkenyl group, and a C1-40 haloalkyl group; and R4, at each occurrence, independently is selected from the group consisting of a -L-C1 -40 alkyl group, a -L-C2-40 alkenyl group, and a -L-C1-40 haloalkyl group, wherein L, at each occurrence, is selected from the group consisting of O, S, and a covalent bond, and each
of the C1-40 alkyl group and the C2-40 alkenyl group optionally is substituted with 1-10 substituents independently selected from the group consisting of a halogen,
—CN, —NH2, —NH(C1-20 alkyl), —N(C1-20 alkyl)2, —SiH3, —SiH(C1-20 alkyl)2 —SiH2(C1-20 alkyl), —Si(C1-20 alkyl)3, an —O—C1-20 alkyl group, and an —S—C1-20 alkyl group.

US Pat. No. 9,408,845

FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS

Northwestern University, ...

1. A method of treating a traumatic brain injury in a subject in need of treatment of a traumatic brain injury comprising
administering to the subject a composition comprising a compound having the following structure:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, excipient or vehicle.

US Pat. No. 9,227,186

SYNTHESIS OF LAYERED METAL SULFIDE ION-EXCHANGERS

Northwestern University, ...

1. A method for the synthesis of a compound of the formula A2xMxSn3-xS6, where x has a value in the range from 0.5 to 1; A is Li+, Na+, K+, Rb+ or Cs+; and M is Mg2+, Ca2+, Mn2+, Zn2+, or Fe2+, wherein the method is a solid state method comprising heating a reaction mixture of A2CO3, M, S and Sn to a temperature and for a time sufficient to produce the compound of the formula A2xMxSn3-xS6, via a solid state reaction.

US Pat. No. 9,181,475

PHOTOLUMINESCENT COMPOUNDS

NORTHWESTERN UNIVERSITY, ...

1. A two-phase material comprising; a first phase of a compound having a formula selected from AMX3, A2MX4, AM2X5 or A2MX6, where the A is selected from elements from Group 1 of the periodic table, the M is C, Ge, Sn or Pb, and X is selected from
elements from Group 17 of the periodic table; and a second phase comprising a metal oxide of the formula (M?Oy?), where y?=1, 1.5 or 2, where M? is selected from elements of Groups 2-4 or elements of Groups 12-15 of the periodic table,
and further wherein M and M? are different elements.

US Pat. No. 9,242,957

THIOPHENE-2-CARBOXIMIDAMIDE BASED SELECTIVE NEURONAL NITRIC OXIDE INHIBITORS

Northwestern University, ...

1. A compound of a formula
wherein L is selected from a covalent bond and divalent CH?CH, CH2CH2, OCH2CH(OH), O(CH2)2O, O(CH2)3O, (CH2)2NH, (CH2)2NHCH2, CH2CH(CH2NH2)CH2CH2, CH2CH(CH2NH2)NHCH2 and OCH(CH2NH2)CH2O moieties; or a salt thereof.

US Pat. No. 9,876,183

CHARGE-TRANSPORTING METAL OXIDE-POLYMER BLEND THIN FILMS

Northwestern University, ...

1. An electronic, optical, or optoelectronic device comprising a metal oxide-polymer blend thin film semiconductor or conductor
component, said component comprising a metal oxide lattice and an electrically insulating polymer dispersed therewithin, wherein
the metal oxide lattice comprises an electrically semiconducting or conducting metal oxide and wherein the electrically insulating
polymer is present at no more than about 20% by weight of the electrically semiconducting or conducting metal oxide.

US Pat. No. 9,617,541

BIOCOMPATIBLE INFINITE COORDINATION POLYMER NANOPARTICLE-NUCLEIC ACID CONJUGATES FOR ANTISENSE GENE REGULATION

NORTHWESTERN UNIVERSITY, ...

1. A compound having a structure

wherein
L is C1-20alkylene or —C(O)NH—C1-20alkylene; and

n is 1 or 2.
US Pat. No. 9,125,942

PARAMAGNETIC METAL-NANODIAMOND CONJUGATES

NORTHWESTERN UNIVERSITY, ...

1. A composition comprising one or more paramagnetic metal ion complexes coupled to a nanodiamond, wherein said paramagnetic
metal ion complexes comprise Gd(III) and DO3A.

US Pat. No. 9,270,277

EMITTER-COUPLED SPIN-TRANSISTOR LOGIC

Northwestern University, ...

1. A logic circuit, comprising:
a spin-transistor having an emitter, a collector and a base;
a first control wire for receiving an input current to create a magnetic field that affects amplification of the spin-transistor;
a first resistor between the spin-transistor collector and one of a low voltage source and a high voltage source;
a second transistor having an emitter, a collector and a base, wherein the emitter of the second transistor is coupled to
the emitter of the spin-transistor;

a second resistor between the second transistor collector and the one of the low voltage source and the high voltage source;
and

a third resistor between the spin-transistor emitter and the other of the low voltage source and the high voltage source.

US Pat. No. 9,150,533

LOCAL COCHLEAR APPLICATION OF STATINS FOR STIMULATING NEURITE REGROWTH IN THE COCHLEA

Northwestern University, ...

1. A method of stimulating neurite growth from spiral ganglion neurons in the inner ear, comprising contacting a neurite with
a statin, or a pharmaceutically acceptable salt thereof, wherein the statin comprises a compound selected from a group consisting
of compounds having formulas (II)-(VII):

US Pat. No. 9,133,311

ENHANCING THE PHYSICAL PROPERTIES OF SEMI-CRYSTALLINE POLYMERS VIA SOLID-STATE SHEAR PULVERIZATION

Northwestern University, ...

1. A method of affecting a mechanical property of a homopolymer, said method comprising:
providing a solid homopolymer component, said homopolymer a single homopolymer; and
applying a mechanical energy to said single homopolymer through solid-state shear pulverization in the presence of cooling
sufficient to maintain said homopolymer in a solid state during said pulverization, said pulverization sufficient to affect
a mechanical property of said single homopolymer.

US Pat. No. 9,120,799

CRYSTALLINE BIPYRIDINIUM RADICAL COMPLEXES AND USES THEREOF

NORTHWESTERN UNIVERSITY, ...

1. A complex comprising (a) CBPQT2(•+) and (b) a compound of formula (I):

wherein the complex has a 3+ charge and is a tris-radical, and

R1 and R2 are each independently selected from the group consisting of alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkenyl,
alkynyl, alkyleneazido, alkylenecycloalkyl, alkyleneheterocycloalkyl, and alkylenearyl,

or a salt thereof.

US Pat. No. 9,428,467

SELECTIVE CALCIUM CHANNEL ANTAGONISTS

NORTHWESTERN UNIVERSITY, ...

1. A method of selectively inhibiting a Cav1.3-calcium ion channel, comprising contacting said Cav1.3-calcium ion channel
with a compound of the formula:

wherein R1 is cyclopentane or cyclohexane, and R2 is a meta-substituted phenethyl group, wherein the compound is a selective
Cav1.3-calcium ion channel inhibitor.

US Pat. No. 9,276,226

ORGANIC-INORGANIC HYBRID MULTILAYER GATE DIELECTRICS FOR THIN-FILM TRANSISTORS

Northwestern University, ...

1. A thin film transistor comprising an organic-inorganic hybrid multilayer dielectric material, a gate electrode in contact
with the organic-inorganic hybrid multilayer dielectric material, a thin film semiconductor, and source and drain electrodes
in contact with the thin film semiconductor, wherein the organic-inorganic hybrid multilayer dielectric material comprises
an inorganic primer layer and one or more bilayers deposited thereon, each bilayer comprising a ?-polarizable layer and an
inorganic oxide capping layer, wherein the inorganic oxide capping layer in each bilayer is coupled to the ?-polarizable layer
via bonds other than phosphonate bonds.
US Pat. No. 9,095,629

MAGNETIC NANOSTRUCTURES AS THERANOSTIC AGENTS

NORTHWESTERN UNIVERSITY, ...

1. A system, comprising
a) a magnetic nanostructure comprising i) a nanoparticle; and ii) a targeting agent, wherein said targeting agent targets
said nanostructure to an A?-oligomer; and

b) a device for generating a radio frequency, wherein said magnetic nanostructure generates heat when exposed to a radio frequency
generated by said radio frequency generator.

US Pat. No. 9,393,550

METHODS OF MAKING NON-COVALENTLY BONDED CARBON-TITANIA NANOCOMPOSITE THIN FILMS AND APPLICATIONS OF THE SAME

NORTHWESTERN UNIVERSITY, ...

10. A method of making non-covalently bonded carbon-titania nanocomposite thin films, comprising:
forming a carbon-based ink;
forming a titania (TiO2) solution;

blade-coating a mechanical mixture of the carbon-based ink and the titania solution onto a substrate; andannealing the blade-coated substrate at a first temperature for a first period of time to obtain the carbon-based titania
nanocomposite thin films,
wherein the carbon-based ink comprises a concentrated single walled carbon nanotube (SWCNT) ink; and
wherein the forming of the concentrated SWCNT ink comprises:
dispersing SWCNT in an ethyl-cellulose (EC)-ethanol solution to form a SWCNT solution;
sonicating the SWCNT solution for a sixth period of time; and
disposing the sonicated SWCNT solution in terpineol to perform solvent exchange and to obtain the concentrated SWCNT ink.

US Pat. No. 9,340,433

TITANIUM OXIDE SPACING BY SIP

Behr Process Corporation,...

1. An encapsulated titanium oxide for coating compositions, the encapsulated titanium oxide consisting of a plurality of pretreated
titanium oxide particles, residues of an initiator attached to surfaces of the pretreated titanium oxide particles, and a
polymeric layer disposed over the pretreated titanium oxide particles and the residues of the initiator, the polymeric layer
consisting of polymer chains that extend from surfaces of the pretreated titanium oxide particles, the polymer chains consisting
of residues of a hydrophilic monomer and optionally residues of a hydrophobic monomer, wherein:
the pretreated titanium oxide particles are titanium oxide particles pretreated with at least one metal oxide;
the initiator has the following formula
X1—R1—X2 wherein:X1 is a leaving group that is replaced by chemically active functional groups on the surfaces of the pretreated titanium oxide
particles;R1 is a C6-C20 hydrocarbon-containing group consisting of components selected from the group consisting of phenyl groups, C1-C10 alkyl groups, C1-C10 allyl, ester, nitrile, benzyl, ether, C1-C4 epoxy, hydroxyl, vinyl, and combinations thereof; andX2 is a halogen.
US Pat. No. 9,416,070

FORMING ETHYLENE

Northwestern University, ...

1. A method of forming ethylene from methane comprising:
contacting supported-palladium with hydrogen sulfide to form a palladium sulfide catalyst; and
contacting the palladium sulfide catalyst with methane to form ethylene.

US Pat. No. 9,384,245

METHOD AND SYSTEM FOR ASSESSING RELEVANT PROPERTIES OF WORK CONTEXTS FOR USE BY INFORMATION SERVICES

Northwestern University, ...

1. A method for obtaining representative text items from a plurality of text items in computer tasks, the method comprising:
receiving first information indicative of a first computer task, the first information including a first plurality of text
items;

determining a first user profile associated with the first computer task;
for each of the first plurality of text items, assigning a first weight with a first magnitude, the first magnitude being
determined based on the first user profile;

ranking the first plurality of text items based on the first weight assigned to each of the first plurality of text items
to produce a first plurality of ranked text items;

generating and storing first representative text items based on the first plurality of ranked text items;
wherein the first computer task is a task other than entering search terms for the purpose of retrieving information;
receiving second information indicative of a second computer task, the second computer task being different than the first
computer task, the second information including a second plurality of text items, wherein the second plurality of text items
is different than the first plurality of text items;

determining a second user profile associated with the second computer task;
for each of the second plurality of text items, assigning a second weight with a second magnitude, the second magnitude being
different than the first magnitude;

ranking the second plurality of text items based on the second weight assigned to each of the second plurality of text items
to produce a second plurality of ranked text items; and

generating and storing second representative text items based on the second plurality of ranked text items;
wherein the second computer task is a task other than entering search terms for the purpose of retrieving information.

US Pat. No. 9,237,889

SUTURE

NORTHWESTERN UNIVERSITY, ...

1. A medical device comprising:
a surgical needle; and
an elongated mesh suture having a first end and a second end located away from the first end, wherein the first end is selected
from the group consisting of (a) an end directly attached to the surgical needle, (b) a free end, and (c) an end having a
loop;

the elongated suture including a tubular wall, a hollow core inside of the tubular wall, and a plurality of pores extending
through the tubular wall, at least some of the pores having a pore size that is greater than or equal to approximately 500
microns such that the pores are adapted to facilitate tissue integration through the tubular wall of the suture when introduced
into a body, wherein the suture is uniform in diameter along substantially its entire length and the diameter is in a range
of approximately 1 mm to approximately 5 mm.

US Pat. No. 9,204,966

PENILE PROSTHESIS

Northwestern University, ...

1. A penile prosthesis implantable in a corpus cavernosum for facilitating an erection, the penile prosthesis comprises:
a) an exoskeleton comprising a shape memory alloy having a dimension that enlarges radially in response to an increase in
temperature around said prosthesis and a cylindrical outer contour along a longitudinal axis;

b) a heat-conducting sheath surrounding the exoskeleton; and
c) a core located within the exoskeleton, the core retaining a fluid within the exoskeleton,
wherein the exoskeleton, the heat-conducting sheath and the core are configured to remain in the corpus cavernosum before,
during and after the erection.

US Pat. No. 9,145,424

TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Northwestern University, ...

1. A compound selected from compounds of a formula

wherein R1 and R2 are independently selected from H, alkyl and arylalkyl moieties; salts; tautomers; or combinations thereof.

US Pat. No. 9,412,852

LOW-TEMPERATURE FABRICATION OF NANOMATERIAL-DERIVED METAL COMPOSITE THIN FILMS

Northwestern University, ...

1. A method of fabricating a transistor device comprising a thin film semiconductor component comprising indium gallium zinc
oxide (IGZO), the method comprising:
depositing a thin film from a nanomaterial dispersion comprising a semiconducting metal oxide nanomaterial in a solvent or
solvent mixture and a binder composition comprising an indium salt, a gallium salt, and a zinc salt in a solvent or solvent
mixture, wherein the indium salt, the gallium salt, and the zinc salt independently comprise either an oxidizing anion or
a fuel anion, provided that (a) if none of the indium salt, the gallium salt and the zinc salt comprises a fuel anion, then
the binder composition further comprises either a fuel or an ammonium salt comprising a fuel anion, and (b) if none of the
indium salt, the gallium salt and the zinc salt comprises an oxidizing anion, then the binder composition further comprises
either an acid comprising an oxidizing anion or an inorganic salt comprising an oxidizing anion, wherein:

the fuel is selected from acetylacetone, CF3COCH2COCF3, CH3COCHFCOCH3, CH3COCH2C(?NH)CF3, CH3C(?NH)CHFC(?NH)CH3, CH3COCH2C(?NCH3)CF3, CH3C(?NCH3)CHFC(?NCH3)CH3, CH3C(?NH)CHFC(?NCH3)CH3, Ph2POCH2COCH3, urea, N-methylurea, citric acid, ascorbic acid, stearic acid, nitromethane, hydrazine, carbohydrazide, oxalyl dihydrazide,
malonic acid dihydrazide, tetra formal tris azine, hexamethylenetetramine, and malonic anhydride,

the fuel anion is selected from acetylacetonate, a citrate, an oxalate, an ascorbate, and a stearate, and
the oxidizing anion is selected from a nitrate, a perchlorate, a chlorate, a hypochlorite, an azide, a peroxide, a superoxide,
a high-valent oxide, an N-oxide, a persulfate, a dinitramide, a nitrocyanamide, a nitroarylcarboxylate, a tetrazolate, and
hydrates thereof, and

the oxidizing anions and the fuel and fuel anions in the binder composition are present in amounts to allow metal oxide formation
and complete combustion of the fuel

and fuel anions; and
annealing the thin film at a temperature of less than or about 350° C. to initiate a combustion reaction between the oxidizing
anions and the fuel and fuel anions, thereby forming a thin film semiconductor component comprising IGZO and converting the
fuel and fuel anions into CO2, H2O, and optionally, N2; wherein the transistor device exhibits a charge mobility of about 3 cm2/Vs or higher.

US Pat. No. 9,367,588

METHOD AND SYSTEM FOR ASSESSING RELEVANT PROPERTIES OF WORK CONTEXTS FOR USE BY INFORMATION SERVICES

Northwestern University, ...

1. A method for obtaining representative text items from a plurality of text items in computer tasks, the method comprising:
receiving first information indicative of a first computer task, the first information including a first plurality of text
items and a first stylistic attribute associated with a first text item in the first plurality of text items;

receiving a genre associated with the first computer task;
determining a first representative stylistic attribute value of the first plurality of text items based on a first frequency
of occurrence of a first stylistic attribute in the first computer task;

for each of the first plurality of text items, assigning a first weight with a first magnitude, the first magnitude being
determined based on the genre and the first representative stylistic attribute value;

wherein the first computer task is a task other than entering search terms for the purpose of retrieving information;
receiving second information indicative of a second computer task, the second computer task being different than the first
computer task, the second information including a second plurality of text items and a second stylistic attribute associated
with a second text item in the second plurality of text items, wherein the second plurality of text items is different than
the first plurality of text items;

determining a second representative stylistic attribute value of the second plurality of text items based on a second frequency
of occurrence of the second stylistic attribute in the second computer task, the second representative stylistic attribute
value being different than the first representative stylistic attribute value;

for each of the second plurality of text items, assigning a second weight with a second magnitude, the second magnitude being
different than the first magnitude;

wherein the second computer task is a task other than entering search terms for the purpose of retrieving information.

US Pat. No. 9,266,735

SEPARATION OF SINGLE-WALLED CARBON NANOTUBES BY SELF-FORMING DENSITY GRADIENT ULTRACENTRIFUGATION

Northwestern University, ...

1. A method of using a density gradient to separate single-walled carbon nanotubes, said method comprising:
providing a nanotube composition comprising at least one surface active block copolymer and a mixture of single-walled carbon
nanotubes, said mixture selected from mixed nanotube diameters, mixed nanotube chiralities, mixed nanotube electronic types
and combinations of said mixtures;

contacting said nanotube composition with a fluid medium capable of forming a density gradient therein under centrifugation,
and centrifuging said nanotube composition; and

separating said nanotube composition into at least one separation fraction enriched with single-walled carbon nanotubes of
at least one of said selected nanotube diameter, nanotube chirality and nanotube electronic type, said single-walled carbon
nanotubes complexed with a said surface active block copolymer, said enrichment relative to said nanotube composition,
said method without pre-centrifugation preparation of a linear density gradient.

US Pat. No. 9,236,194

METAL OXIDE-ENCAPSULATED DYE-SENSITIZED PHOTOANODES FOR DYE-SENSITIZED SOLAR CELLS

Northwestern University, ...

1. A dye-sensitized semiconducting metal oxide film comprising:
(a) a porous film comprising a semiconducting metal oxide, the porous film having a surface;
(b) photosensitizing dye molecules adsorbed directly onto the surface of the porous film, each of the photosensitizing dye
molecules comprising a chromophore and a molecular anchoring group, wherein the molecular anchoring group of the each of the
photosensitizing dye molecules attaches the chromophore of the each of the photosensitizing dye molecules to the porous film;
and

(c) an encapsulating layer on the surface of the porous film, the encapsulating layer comprising the semiconducting, metal
oxide, wherein the encapsulating layer at least partially encapsulates the molecular anchoring group of the each of the photosensitizing
dye molecules, but does not cover chromophore of the each of the photosensitizing dye molecules the.

US Pat. No. 9,090,933

CANCER SCREENING BY DETECTION OF ULTRASTRUCTURAL AND MOLECULAR MARKERS

Northwestern University, ...

1. A method of isolating mucus layer colonocytes from a stool sample comprising:
(a) gently agitating the stool sample in a wash solution;
(c) centrifuging the stool sample in the wash solution to form a cell pellet;
(d) disrupting the cell pellet in a cell preservation solution to form a resuspended cell pellet;
(e) filtering the resuspended cell pellet through a first strainer and collecting supernatant;
(f) filtering the supernatant through a second strainer to retain mucus layer colonocytes; and
(g) combining the mucus layer colonocytes with at least one mucolytic agent and at least one chelating agent to form a suspension
of isolated mucus layer colonocytes.

US Pat. No. 9,642,949

IMMOBILIZATION OF AN ACTIVE AGENT ON A SUBSTRATE

BAXTER INTERNATIONAL INC....

1. A substrate having an active agent immobilized on a surface thereof, the substrate comprising a layer of a primer compound
on the substrate surface, wherein the layer of the primer compound includes a compound including a trihydroxyphenyl group
coupled thereto selected from the group consisting of gallic acid, phloroglucinol carboxylic acid, gallamide, 5-methyl-benzene-1,2,3-triol,
3,4,5-trihydroxybenzaldehyde, 2,3,4-trihydroxybenzaldehyde, gallacetophenone, 3,4,5-trihydroxybenzamide, 2,3,4-trihydroxybenzoic
acid, 5-hydroxydopamine hydrochloride, methyl gallate, derivatives thereof, salts of the foregoing, and combinations thereof,
and wherein the compound comprising the trihydroxyphenyl group includes an active agent coupled thereto.

US Pat. No. 9,403,150

METAL CATALYST COMPOSITION

Northwestern University, ...

1. A method of forming a metal catalyst composition, comprising:
performing a plurality of atomic layer deposition cycles to form metal oxide over-coat on a supported metal catalyst, where
one or more of the atomic layer deposition cycles include sequential steps:

(a) contacting a supported metal catalyst surface with a ligand-containing metal oxide precursor for a predetermined contact
time to form an intermediate layer having a plurality of metal moieties that chemically bond to the supported metal catalyst
surface;

(b) reacting the metal moieties with water for a predetermined reaction time to convert at least a portion of the ligands
to hydroxyl groups thereby forming a layer of the metal oxide, metal hydroxide, or metal oxyhydroxide over-coat on the supported
metal catalyst surface or a previously formed layer of the metal oxide, metal hydroxide, or metal oxyhydroxide over-coat;

(c) prior to replicating sequential steps (a) and (b) to form an additional layer of the metal oxide over-coat, contacting
the layer of the metal oxide, hydroxide, oxyhydroxide over-coat formed in step b) with an inert gas for a predetermined final
stripping time to remove unreacted water; and

(d) activating the metal oxide, metal hydroxide, metal oxyhydroxide over-coat, after forming a final layer of the said over-coat,
in the presence of a non-reducing gas at a temperature within a range from 500° C. to 800° C. for 60 minutes to 10 hours to
form a layer of metal oxide having a thickness of from 1 nanometer to 100 nanometers with a plurality of pores therein, where
at least 80 percent of the plurality of pores have a diameter within a range of 0.3 nanometers to 5 nanometers, and where
the metal catalyst composition reduces an amount of coke formed during a dehydrogenation or an oxidative dehydrogenation reaction,
as compared to same supported metal catalysts without the metal oxide over-coat.

US Pat. No. 9,383,357

BIOMARKER FOR REPLICATIVE SENESCENCE

NORTHWESTERN UNIVERSITY, ...

1. A method comprising:
(a) contacting a population of chemically-fixed human cells comprising both proliferating and senescent cells with non-human
antibodies that specifically bind human lamin B1 (anti-LB 1 antibodies) under conditions which result in formation of a complex
between the anti-LB 1 antibodies and human lamin B1 present on cells within the population, wherein said anti-LB 1 antibodies
bind to lamin B1, but not to Lamin B2 and Lamin A/C;

(b) binding fluorophore-tagged secondary antibodies to said anti-LB 1 antibodies; and
(c) detecting fluorescence from said fluorophore.

US Pat. No. 9,376,690

TEMPLATED NANOCONJUGATES

NORTHWESTERN UNIVERSITY, ...

1. A composition comprising a nanoconjugate, the nanoconjugate having a defined structure and comprising a plurality of polynucleotides
crosslinked to each other in a monolayer, said structure defined by a surface providing a template upon which the structure
is assembled.

US Pat. No. 9,114,116

NEUROPROTECTION BY HEPATIC CELLS AND HEPATOCYTE SECRETORY FACTORS

NORTHWESTERN UNIVERSITY, ...

1. A method of treating a subject experiencing cerebral ischemia comprising: administering a composition to said subject,
wherein said composition comprises at least one isolated hepatocyte secretory factor which is RELM?.

US Pat. No. 9,811,194

TOUCH INTERFACE DEVICE AND METHODS FOR APPLYING CONTROLLABLE SHEAR FORCES TO A HUMAN APPENDAGE

Northwestern University, ...

1. A touch interface device comprising:
a touch surface;
a sensor that measures a plurality of locations when the touch surface is touched by a plurality of appendages of an operator;
one or more actuators coupled with the touch surface that move the touch surface in a swirling motion;
a plurality of electrodes disposed below the touch surface and an insulating layer on the electrodes;
an electronic controller that controls voltage on the electrodes;
wherein an electrostatic normal force acts on each of the plurality of appendages, the electrostatic normal force being controlled
by adjusting the voltage applied to each of the plurality of appendages by each electrode lying beneath the appendage,

wherein the electrostatic normal force generated by the voltage applied to each of the plurality of appendages is synchronized
with the swirling motion by basing a frequency of the swirling motion on the frequency of application of the electrostatic
normal force such that a distinct persistent shear force is simultaneously applied to each of the respective plurality of
appendages.

US Pat. No. 9,416,010

SORTING TWO-DIMENSIONAL NANOMATERIALS BY THICKNESS

Northwestern University, ...

1. A method of preparing an aqueous graphene dispersion, said method comprising:
providing a composition comprising a graphite composition comprising natural graphene, at least one non-ionic surface active
polymeric component, said polymeric component is a block copolymer of oxyethylene and oxypropylene, and an aqueous medium;

sonicating said composition to exfoliate said graphite composition and disperse said graphene component within said aqueous
medium; and

centrifuging said sonicated composition to separate said dispersed graphene component therefrom.

US Pat. No. 9,365,456

HIGHLY-DISPERSED CARBON NANOTUBE-REINFORCED CEMENT-BASED MATERIALS

Northwestern University, ...

1. A method of making a nanocomposite cementitious material, comprising sonicating an aqueous solution containing surfactant
and carbon nanotubes to form a dispersion of carbon nanotubes in the solution, and mixing the dispersion of carbon nanotubes
and a cement to form a nanocomposite cementitious material wherein the carbon nanotubes are present in an amount of about
0.048% to about 0.08% by weight of the cement and further wherein the nanocomposite cementitious material exhibits a modified
nanostructure so that the average values of stiffness and hardness of C-S-H, as determined by nanoindentation tests, are higher
compared to the same cementitious material without carbon nanotubes.

US Pat. No. 9,090,589

SPECIFIC NNOS INHIBITORS FOR THE THERAPY AND PREVENTION OF HUMAN MELANOMA

Northwestern University, ...

1. A method of reducing expression of neuronal nitric oxide synthase, said method comprising:
providing a compound selected from compounds of a formula
wherein R1 is selected from H, halogen, methyl and halomethyl moieties; R2 is selected from H, alkyl and haloalkyl moieties; Z is selected from O and NH; and R4 is selected from H, alkyl, halogen and haloalkyl moieties, and salts thereof; and
contacting said compound with a cellular medium comprising one of human melanocytes, melanoma cells and a combination thereof,
said compound in an amount sufficient to reduce induction of neuronal nitric oxide synthase expression, thereby reducing ultra-violet
induced nitric oxide production in a human melanocyte or melanoma cell.

US Pat. No. 9,078,942

TITANIUM DIOXIDE, SINGLE-WALLED CARBON NANOTUBE COMPOSITES

NORTHWESTERN UNIVERSITY, ...

1. A composition comprising: a composite material comprising TiO2 particles and single-walled carbon nanotubes (SWCNTs), wherein said SWCNTs decorate, bridge between, and are interwoven among
said TiO2 particles in said composite material, and wherein said TiO2 particles have an average diameter between 120 and 140 nm.

US Pat. No. 9,399,803

COMPOUNDS AND METHODS TO ISOLATE GOLD

Northwestern University, ...

1. A method for isolating gold from a gold-bearing material, comprising:
adding HX and an acid to the gold-bearing material to form a first dissolved gold solution;
adding a base to the first dissolved gold solution to form a second dissolved gold solution;
adding a cyclodextrin to the second dissolved gold solution to form a precipitate in the second dissolved gold solution; and
isolating the precipitate from the second dissolved gold solution,
wherein HX comprises a hydrogen halide and the precipitate comprises a gold-cyclodextrin complex.
US Pat. No. 9,388,256

PEROXY-DERIVATIVE FUNCTIONALIZATION OF POLYPROPYLENE VIA SOLID-STATE SHEAR PULVERIZATION

Northwestern University, ...

1. A method of functionalizing polypropylene with a benzoyloxy moiety, said method comprising:
providing a mixture comprising a polymer comprising a polypropylene component and benzoyl peroxide; and
applying a mechanical energy to said mixture through solid-state shear pulverization in the presence of cooling at least partially
sufficient to maintain said polymer in a solid state during said pulverization, said pulverization at least partially sufficient
to graft a benzoyloxy moiety onto said polypropylene component, said pulverization providing a benzoyloxy-functionalized polymer.

US Pat. No. 9,228,236

ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4

Northwestern University, ...

1. An in vitro method of detecting a mutation in a TRPV4 nucleic acid in a biological sample comprising: (a) obtaining a biological
sample from a subject; (b) contacting a TRPV4 nucleic acid from the biological sample with an oligonucleotide comprising a
fragment of a TRPV4 nucleic acid that specifically binds to a TRPV4 nucleic acid encoding a cysteine at position 316 of the
TRPV4 protein and which does not bind to a TRPV4 nucleic acid encoding an arginine at position 316 of the TRPV4 protein; or
with an oligonucleotide comprising a fragment of a TRPV4 nucleic acid that specifically binds to a TRPV4 nucleic acid encoding
a histidine at position 269 of the TRPV4 protein and which does not bind to a TRPV4 nucleic acid encoding an arginine at position
269 of the TRPV4 protein; and (c) detecting hybridization of the TRPV4 nucleic acid from the biological sample with the oligonucleotide,
wherein hybridization is indicative of a mutation in a TRPV4 nucleic acid in the biological sample, and wherein the mutation
encodes for a TRPV4-R269H or TRPV4-R316C mutation.

US Pat. No. 9,613,911

SELF-SIMILAR AND FRACTAL DESIGN FOR STRETCHABLE ELECTRONICS

The Board of Trustees of ...

54. An electronic circuit comprising:
an elastic substrate; and
a stretchable metallic or semiconducting device component supported by said elastic substrate; said stretchable metallic or
semiconducting device component comprising a plurality of electrically conductive elements each having a primary unit cell
shape, said electrically conductive elements connected in a sequence having a secondary shape providing an overall two-dimensional
spatial geometry characterized by a plurality of spatial frequencies; wherein said two-dimensional spatial geometry is a self-similar
two-dimensional geometry;

wherein said two-dimensional spatial geometry of said stretchable metallic or semiconducting device component allows for accommodation
of elastic strain along one or more in-plane or out of plane dimensions, thereby providing stretchability of said electronic
circuit.

US Pat. No. 9,566,355

BACTERIA-TARGETED MAGNETIC RESONANCE CONTRAST AGENTS

Northwestern University, ...

1. A method for imaging bacteria in a subject comprising:
a) administering a contrast agent to a subject, wherein said contrast agent is selected from the group consisting of:
wherein M is a metal ion, and wherein R is a linker moiety selected from the group consisting of:
i) an amino acid,
ii) a peptide,
iii) a divalent branched or unbranched carbon chain comprising from about 2 to about 30 carbon atoms,
iv) a divalent branched or unbranched carbon chain comprising from about 2 to about 30 carbon atoms, which the chain is substituted
with one or more hydroxyl groups or oxo groups,

v) a divalent branched or unbranched carbon chain comprising from about 2 to about 30 carbon atoms, wherein one or more of
the carbon atoms in the chain is replaced with an aryl ring, a hetoroaryl ring, or with a non-peroxide —O—, —S— or —NH—,

vi) —C(?O)NH(CH2)3—;

vii) —C(?O)NH(CH2)5C(?O)NH(CH2)—;

viii —CH2OC(?O)NH(CH2)2O(CH2)2O(CH2)—, and

ix) a divalent heteroaryl group, and
b) performing imaging of said subject and detecting a signal from said contrast agent if said subject is infected with bacteria.

US Pat. No. 9,044,392

NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME

Wisconsin Alumni Research...

1. A method of treating infant, acute, or adult respiratory distress syndromes, and pulmonary disorders involving deficient
or dysfunctional lung surfactant in mammals, the method comprising:
administering to a mammalian subject in need thereof an artificial lung surfactant composition comprising a nylon-3 homopolymer
or nylon-3 copolymer as an artificial lung surfactant present in the artificial lung surfactant composition in an amount effective
to treat a respiratory distress syndrome or pulmonary disorder involving deficient or dysfunctional lung surfactant in the
mammalian subject, wherein monomers of the nylon-3 homopolymer or nylon-3 copolymer are selected from the group consisting
of:


wherein:
R3, R4, R5, and R6 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-C6-alkyl, aryl, C1-C6-alklyaryl, amino, protected-amino, amino-C1-C6-alkyl, and protected-amino-C1-C6-alkyl; or

one of R3 and R4 combined with one of R5 and R6, together with the carbon atoms to which they are attached, define a cyclic moiety “A”

wherein “A” is selected from the group consisting of substituted or unsubstituted C5-C12 cycloalkyl, C5-C12 cycloalkenyl, and five- to twelve-membered heterocyclic;
provided that at least two of R3, R4, R5, or R6 are not hydrogen; and

wherein “n” is a positive integer.
US Pat. No. 9,044,419

VACCINE COMPOSITIONS COMPROMISING ?S-CRYSTALLIN FOR INDUCING IMMUNE RESPONSES AGAINST COMPONENTS OF DRUSEN

Northwestern University, ...

1. A method for treating drusen in a patient having macular drusen or at risk for developing macular drusen, the method comprising
administering a pharmaceutical composition comprising ?s-crystallin to the patient in a manner effective for stimulating an antibody-mediated immune response against ?s-crystallin, wherein the composition comprises:
(a) an effective amount of ?s-crystallin comprising the full-length amino acid sequence of SEQ ID NO:1, wherein the amount of ?s-crystallin is 1-80 ?g and the amount is effective for stimulating an antibody-mediated immune response against ?s-crystallin after the composition is administered to the patient; and

(b) a pharmaceutical carrier, excipient, or diluent.

US Pat. No. 9,360,660

METHODS AND APPARATUS FOR LASER SCANNING STRUCTURED ILLUMINATION MICROSCOPY AND TOMOGRAPHY

NORTHWESTERN UNIVERSITY, ...

1. A structured illumination microscopy system comprising:
a laser source to generate excitation illumination directed toward a target object;
a modulator to modulate the excitation illumination temporally in a controllable, periodic spatial pattern to be constructed
on the target object to provide sub-diffractional resolution in a lateral direction with respect to the target object;

two synchronized laser scanning mirrors in confocal arrangement, the two laser scanning mirrors units to be synchronized and
controlled to translate the temporally modulated illumination into the periodic spatial pattern on the target object, a first
of the two scanning mirrors to receive the modulated excitation illumination and project the modulated excitation illumination
with a controllable phase delay on the target object in periodic spatial pattern by linearly steering a focal spot of the
modulated excitation illumination in the lateral direction to transform the modulated excitation illumination into the periodic
spatial pattern, wherein tuning of a frequency of the temporal modulation determines a period of the spatial pattern, and
a second of the two scanning mirrors to receive emission fluorescence from the target object generated by the periodic spatial
pattern of modulated excitation illumination and project the emission fluorescence;

a detector to collect emission fluorescence from the target object via the second of the two scanning mirrors for processing
to form an image; and

a computing device to control the modulator to modulate the excitation illumination temporally in a controllable, periodic
spatial pattern and to control the periodic spatial pattern with respect to the first scanning mirror to enhance lateral resolution
beyond a diffraction limit in the image formed based on the emission fluorescence collected from the target object via the
second scanning mirror by shifting high spatial frequencies in a Fourier domain into a detectable range to enhance the lateral
resolution beyond the diffraction limit, wherein the computing device further controls the modulation of the excitation illumination
to include a non-integer number of modulation periods to control the phase delay.

US Pat. No. 9,207,243

USE OF GLUT4 INHIBITORS AND DNA DAMAGING AGENTS FOR TREATING MULTIPLE MYELOMA

Northwestern University, ...

1. A method of treating multiple myeloma in a patient having multiple myeloma, the method comprising:
(a) administering, a GLUT4 inhibitor to the patient, wherein the GLUT4 inhibitor inhibits glucose transport by GLUT4 and wherein
the GLUT4 inhibitor is ritonavir; and (b) administering a DNA damaging agent to the patient, wherein the DNA damaging agent
is doxorubicin.

US Pat. No. 9,110,533

HAPTIC DEVICE WITH CONTROLLED TRACTION FORCES

NORTHWESTERN UNIVERSITY, ...

1. A haptic device comprising a substrate having a surface and one or more actuators that subject the substrate to lateral
oscillation, wherein a net shear force acts on a user's finger or an object in contact with the surface of the substrate,
and the net shear force is an average of a higher shear force over a portion of a lateral oscillation cycle and a lower shear
force over a remainder of the lateral oscillation cycle.

US Pat. No. 9,372,397

POLYMER PEN LITHOGRAPHY

NORTHWESTERN UNIVERSITY, ...

1. A method for sub-micron scale printing of indicia on a substrate surface, comprising:
coating a tip array with a patterning composition, the tip array comprising a compressible elastomeric polymer comprising
a plurality of non-cantilevered tips each having a radius of curvature of less than about 1 ?m and a common substrate comprising
a compressible elastomeric polymer, the tip array and the common substrate mounted onto a rigid support and the tip array,
common substrate, and rigid support together being at least translucent;

contacting the substrate surface for a first contacting period of time and at a first contacting pressure with all or substantially
all of the coated tips of the array to deposit the patterning composition onto the substrate surface and form substantially
uniform indicia with all or substantially all of said coated tips, the indicia having a dot size (or line width) of less than
1 ?m.

US Pat. No. 9,352,968

GRAPHENE MATERIALS HAVING RANDOMLY DISTRIBUTED TWO-DIMENSIONAL STRUCTURAL DEFECTS

NORTHWESTERN UNIVERSITY, ...

14. A method, comprising:
a) exposing a plurality of graphene sheets to an acid creating at least one defect pore formed from a carbon vacancy disposed
within at least one of the plurality of graphene sheets;

b) mixing the plurality of graphene sheets with electrochemically active particles, wherein the electrochemically active particles
are dispersed between adjacent graphene sheets;

c) removing the acid from the plurality of graphene sheets; and
d) exposing the mixture of graphene sheets and electrochemically active particles to an elevated temperature, thereby forming
a material structure having a network of graphitic regions, wherein the network of graphitic regions has at least one crystalline
structure portion and at least one disordered structure portion.

US Pat. No. 9,348,871

METHOD AND SYSTEM FOR ASSESSING RELEVANT PROPERTIES OF WORK CONTEXTS FOR USE BY INFORMATION SERVICES

Northwestern University, ...

1. A method for obtaining representative text items from a plurality of text items in computer tasks, the method comprising:
receiving first information indicative of a first computer task, the first information including a first plurality of text
items;

determining a genre associated with the first computer task;
determining a first representative field attribute of the genre based on a first frequency of occurrence of the first representative
field attribute in the genre;

for each of the first plurality of text items, assigning a first weight with a first magnitude, the first magnitude being
determined based on the genre and the first representative field attribute;

ranking the first plurality of text items based on the first weight assigned to each of the first plurality of text items
to produce a first plurality of ranked text items;

generating and storing first representative text items based on the first plurality of ranked text items;
wherein the first computer task is a task other than entering search terms for the purpose of retrieving information;
receiving second information indicative of a second computer task, the second computer task being different than the first
computer task, the second information including a second plurality of text items, wherein the second plurality of text items
is different than the first plurality of text items;

determining a second representative field attribute of the genre based on a second frequency of occurrence of the second representative
field attribute in the genre;

for each of the second plurality of text items, assigning a second weight with a second magnitude that is determined based
on the genre and the second representative field attribute, the second magnitude being different than the first magnitude;

ranking the second plurality of text items based on the second weight assigned to each of the second plurality of text items
to produce a second plurality of ranked text items; and

generating and storing second representative text items based on the second plurality of ranked text items;
wherein the second computer task is a task other than entering search terms for the purpose of retrieving information.

US Pat. No. 9,309,217

CATALYTIC ENANTIOSELECTIVE SYNTHESIS OF 2-ARYL CHROMENES AND RELATED PHOSPHORAMIDITE LIGANDS AND CATALYST COMPOUNDS

Northwestern University, ...

1. A method for asymmetric synthesis of a 2-aryl chromene compound, said method comprising:
providing a reaction medium comprising an o-arylallyl-substituted phenoxy ester compound of a formula
wherein X is selected from alkylcarbonyl and arylcarbonyl moieties, LG is a leaving group selected from alkoxycarbonyl groups,
R is selected from H, halo, alkyl and alkoxy moieties and Ar is selected from aryl and substituted aryl moieties, said substituents
selected from halo, alkyl, alkoxy, nitro and haloalkyl substituents, multiple said substituents and combinations thereof;
introducing a palladium (II) catalyst precursor compound and a phosphoramidite ligand compound to said reaction medium; and
reacting said phenoxy ester compound with a base component to promote intramolecular cyclization and provide an asymmetric
2-aryl chromene compound of a formula


US Pat. No. 9,204,979

ARTIFICIAL ANKLE, ARTIFICIAL FOOT AND ARTIFICIAL LEG

NORTHWESTERN UNIVERSITY, ...

1. Artificial ankle (3) comprising
a housing (4) comprising a hollow body (40) for retaining a hydraulic fluid, the hollow body (40) having an inner face, at least a part thereof having a cylindrical surface area (41);

a vane type piston (50) arranged in the hollow body (40), the vane type piston (50) being pivotable about the rotational axis of said cylindrical surface area (41) in a sealing manner with at least said cylindrical surface thereby separating in a fluid tight manner both sides of the
vane type piston (50), and the vane type piston (50) having an aperture (502) to allow fluid to move between both sides of the piston (50);

at least one gravity controlled means (7) for opening or closing said aperture (502);

the piston (50) having a supporting element (51a, 51b, 507) at at least one of its axial ends, the supporting element (51a, 51b, 507) being arranged in a fluid tight sealing manner in order to retain said hydraulic fluid within the hollow body (40); and

attachment means (6) for attaching a shank to the artificial ankle (3), said attaching means (6) being fixed to the at least one supporting element;

wherein the vane type piston (50) and the gravity controlled means (7) are configured to close said aperture (502), when the attachment means (6) is in a position so as to fix a shank in a substantially vertical position; and

the hollow body (40) comprises a separating member (42) configured to separate the inner volume of the hollow body (40) in two separate partial volumes (43, 44), the partial volumes being separated from each other in a fluid tight manner, the partial volumes (43, 44) being bordered each by one side of the vane type piston (50).

US Pat. No. 9,126,997

SYNERGISTIC EFFECT OF GLUCOCORTICOID RECEPTOR AGONISTS IN COMBINATION WITH PROTEOSOME INHIBITORS FOR TREATING LEUKEMIA AND MYELOMA

Northwestern University, ...

1. A method of treating leukemia or myeloma comprising administering to a patient in need thereof a proteasome inhibitor and
administering to the patient a glucocorticoid receptor (GR) agonist, wherein the proteasome inhibitor is administered before,
concurrently with, or after the GR agonist is administered.

US Pat. No. 9,828,259

EXCAGE: SYNTHESIS OF VIOLOGEN-LIKE PYRIDINIUM-BASED CAGES FOR THE SELECTIVE CAPTURE OF POLYCYCLIC AROMATIC HYDROCARBONS

Northwestern University, ...

1. A compound salt of formula (I):
and PF6?.
US Pat. No. 9,517,275

TARGETED THERAPY FOR THE PREVENTION OF RESTENOSIS IN THE CARDIOVASCULAR SYSTEM

Northwestern University, ...

1. A peptide amphiphile comprising:
(a) a hydrophobic non-peptidic segment;
(b) a ?-sheet-forming peptide segment;
(c) a charged peptide segment;
(d) a targeting moiety, wherein the targeting moiety comprises a binding sequence for collagen IV and comprises a 6 amino
acid segment with at least 50% sequence identity with KLVWLPK (SEQ ID NO: 2); and

(e) a therapeutic agent;
wherein the hydrophobic non-peptidic segment is covalently attached to the N-terminus of the ?-sheet-forming peptide segment;
wherein the C-terminus of the ?-sheet-forming peptide segment is covalently attached to the N-terminus of the charged peptide
segment; and

wherein the C-terminus of the charged peptide segment is covalently attached to the N-terminus of the targeting moiety.

US Pat. No. 9,348,872

METHOD AND SYSTEM FOR ASSESSING RELEVANT PROPERTIES OF WORK CONTEXTS FOR USE BY INFORMATION SERVICES

Northwestern University, ...

1. A method for obtaining representative text items from a plurality of text items in computer tasks, the method comprising:
receiving first information indicative of a first computer task, the first information including a first plurality of text
items;

determining a genre associated with the first computer task;
determining first representative location information of the genre based on a first frequency of occurrence of identical text
associated with the first representative location information in the genre;

for each of the first plurality of text items, assigning a first weight with a first magnitude, the first magnitude being
determined based on the genre and the first representative location information;

ranking the first plurality of text items based on the first weight assigned to each of the first plurality of text items
to produce a first plurality of ranked text items;

generating and storing first representative text items based on the first plurality of ranked text items;
wherein the first computer task is a task other than entering search terms for the purpose of retrieving information;
receiving second information indicative of a second computer task, the second computer task being different than the first
computer task, the second information including a second plurality of text items, wherein the second plurality of text items
is different than the first plurality of text items;

determining second representative location information of the genre based on a second frequency of occurrence of identical
text associated with the second representative location information;

for each of the second plurality of text items, assigning a second weight with a second magnitude that is determined based
on the genre and the second representative location information, the second magnitude being different than the first magnitude;

ranking the second plurality of text items based on the second weight assigned to each of the second plurality of text items
to produce a second plurality of ranked text items; and

generating and storing second representative text items based on the second plurality of ranked text items;
wherein the second computer task is a task other than entering search terms for the purpose of retrieving information.

US Pat. No. 9,334,297

CHIRAL IMIDAZOLIUM SALTS FOR ASYMMETRIC CATALYSIS

Northwestern University, ...

1. A catalyst compound selected from a group consisting of

US Pat. No. 9,296,843

SUBSTRATE-INDEPENDENT LAYER-BY-LAYER ASSEMBLY USING CATECHOL-FUNCTIONALIZED POLYMERS

NORTHWESTERN UNIVERSITY, ...

1. A catechol-functionalized polymer comprising the structure:

wherein “n” has a value in the range from 10 to 10,000; and
wherein “x” has a value in the range from 1 to 5,000.

US Pat. No. 9,168,679

PROGRAMMABLE SOFT LITHOGRAPHY: SOLVENT-ASSISTED NANOSCALE EMBOSSING

Northwestern University, ...

1. A method of forming a master mold, the method comprising:
casting an elastomer against a nanoscale master template surface having a template surface pattern array;
removing the cast elastomer from the template surface as an elastomer mold;
wetting the elastomer mold with a suspended polymer;
contacting the wet elastomer mold with a thermoplastic master mold substrate;
removing the contacted substrate from the elastomer mold as a suspended polymer patterned master mold having an initially
constant pattern feature size and spacing with respect to pattern features of the template surface pattern array and having
a tunable pattern density across a range from 50% less than to 100% greater than the initial pattern density; and

manipulating the master mold so as to either increase or decrease the initial pattern density.

US Pat. No. 9,986,924

IMPLANTABLE BIOMEDICAL DEVICES ON BIORESORBABLE SUBSTRATES

The Board of Trustees of ...

1. An implantable biomedical device for actuating a target tissue or sensing a parameter associated with the target tissue in a biological environment, said device comprising:a bioresorbable substrate;
an electronic device comprising one or more metallic conductor components including at least one electrode supported by said bioresorbable substrate, wherein at least one of said metallic conductor components has at least one physical dimension less than or equal to 100 microns;
a barrier layer encapsulating at least a portion of said metallic conductor components; and
a transmitter or a receiver operationally connected to said one or more metallic conductor components;wherein said bioresorbable substrate, said electronic device, and said barrier layer provide a net bending stiffness of the implantable biomedical device of less than 1×109 GPa ?m4; and wherein upon contact with said biological environment said bioresorbable substrate is at least partially resorbed, and the Young's modulus of the implantable biomedical device decreases by at least 20% upon complete or partial resorption of the bioresorbable substrate, thereby establishing an interface providing for conformal contact between said electronic device and said target tissue.
US Pat. No. 9,895,468

IMMOBILIZATION OF AN ACTIVE AGENT ON A SUBSTRATE

BAXTER INTERNATIONAL INC....

1. A method of immobilizing an active agent on a substrate surface, comprising the steps of:
depositing a primer compound on a substrate, thereby forming a primed substrate;
contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated
primed substrate; and

contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby forming a substrate with
an active agent immobilized on the surface thereof, wherein the compound including a trihydroxyphenyl group is selected from
the group consisting of gallic acid, phloroglucinol carboxylic acid, gallamide, 5-methyl-benzene-1,2,3-triol, 3,4,5-trihydroxybenzaldehyde,
2,3,4-trihydroxybenzaldehyde, gallacetophenone, 3,4,5-trihydroxybenzamide, 2,3,4-trihydroxybenzoic acid, 5-hydroxydopamine
hydrochloride, methyl gallate, pyrogallol, salts of the foregoing, and combinations thereof.

US Pat. No. 9,844,600

INJECTABLE THERMORESPONSIVE POLYELECTROLYTES

NORTHWESTERN UNIVERSITY, ...

1. A copolymer comprising:
(a) an N-alkyl acrylamide residue; and
(b) a polyester comprising: citric acid monomer, polyethylene glycol monomer, and glycerol 1,3-diglycerolate diacrylate monomer;wherein the N-alkyl acrylamide residue directly covalently linked to the glycerol 1,3-diglycerolate diacrylate monomer.
US Pat. No. 9,463,186

TREATMENT FOR DOPAMINERGIC DISORDERS

Northwestern University, ...

1. A method of treatment for Parkinson's disease comprising: administering to a human subject having Parkinson's disease
i) a first compound that comprises isradipine, and
ii) a second compound that comprises rasagiline,
wherein said administering provides at least 0.5 mg, and no more than 5 mg, of said isradipine per day, and
wherein said administering is repeated for multiple days.

US Pat. No. 9,327,448

METHODS FOR FABRICATING THREE-DIMENSIONAL METALLIC OBJECTS VIA ADDITIVE MANUFACTURING USING METAL OXIDE PASTES

Northwestern University, ...

1. A method of forming a three-dimensional metallic object, the method comprising:
(a) extruding a paste comprising metal oxide particles or non-oxide metal ceramic particles; a polymeric binder; and an organic
solvent, through a tip via extrusion-based rapid prototyping, to deposit sequential layers of the paste on a substrate, whereby
a three-dimensional metal oxide object or a three-dimensional non-oxide metal ceramic object is formed on the substrate, and

(b) exposing the three-dimensional metal oxide object or the three-dimensional non-oxide metal ceramic object to a reducing
gas at a temperature and for a period of time sufficient to reduce and to sinter the metal oxide particles or the non-oxide
metal ceramic particles, whereby the three-dimensional metallic object is formed,

wherein the metal oxide particles and the non-oxide metal ceramic particles are reducible and are reduced by step (b) to form
the metal of the three-dimensional metallic object.

US Pat. No. 9,290,495

TETRACATIONIC CYCLOPHANES AND THEIR USE IN THE SEQUESTRATION OF POLYAROMATIC HYDROCARBONS BY WAY OF COMPLEXATION

Northwestern University, ...

1. A cyclophane of formula I:

wherein n?0; R is independently selected from the group consisting of H, alkyl groups, alkenyl groups, alkynyl groups, aryl
groups, alkoxy groups, OH, NH2, SH, F, Cl, Br, I, P(R1)2, CHO, COOR1, COOM, CH2OR1, CH2OM, OR1, NHCOR1, CONHR1, CONHM, CON(R1)2, N3, NO2, B(OR1)2, B(OM)2, CN, N(R1)3+, P(R1)3+, PO(R1)2, and OM, where R1 is independently selected from the group consisting of H, alkyl groups, alkenyl groups, alkynyl groups, and aryl groups and
M is independently selected from the group consisting of Li, Na, K, Rb and Cs; and X? is an organic or inorganic negatively charged ion.

US Pat. No. 9,093,056

AUDIO SEPARATION SYSTEM AND METHOD

NORTHWESTERN UNIVERSITY, ...

1. A method comprising:
determining a first spectrogram of an audio signal;
defining a similarity matrix of the audio signal based on the first spectrogram and a transposed version of the first spectrogram;
identifying two or more similar frames in the similarity matrix that are more similar to a designated frame than to one or
more other frames in the similarity matrix;

creating a repeating spectrogram model based on the two or more similar frames that are identified in the similarity matrix;
deriving a mask based on the repeating spectrogram model and the first spectrogram of the audio signal, the mask representative
of similarities between the repeating spectrogram model and the first spectrogram of the audio signal; and

extracting a repeating structure from the audio signal by applying the mask to the audio signal.

US Pat. No. 9,872,637

MEDICAL EVALUATION SYSTEM AND METHOD USING SENSORS IN MOBILE DEVICES

The Rehabilitation Instit...

1. A mobile computing device comprising:
an alarm indicator,
a motion sensor that detects motion of the patient and generates sensory data representing the patient motion,
a computer processor configured to:
extract medically relevant data from the sensory data, the relevant data including one or more features of interest in the
sensory data,

derive one or more surrogate biomarkers from the relevant data, the surrogate biomarkers representative of at least one of
a state of a medical condition or a progression of a medical condition of the patient,

identify the patient as a specific patient; and
provide a real-time intervention alarm through the alarm indicator when the surrogate biomarkers approach a danger level or
threshold that indicates a likelihood of an adverse event occurring to the patient, wherein the real-time intervention alarm
is provided prior to the occurrence of the adverse event,

wherein the real-time intervention alarm is based on one or more changes in the relevant data and includes a notification
directing the patient to change a current activity of the patient.

US Pat. No. 9,619,903

DEVICES, METHODS, AND SYSTEMS OF FUNCTIONAL OPTICAL COHERENCE TOMOGRAPHY

NORTHWESTERN UNIVERSITY, ...

1. A method for imaging a target, the method comprising:
a. performing optical coherence tomography (OCT) scanning on a target with one or more beams of low coherence light, wherein
the one or more beams of low coherence light comprise one or more wavelengths and the one or more beams of light are used
to perform a single measurement;

b. acquiring optical information from reflected signals generated by the performed OCT scanning in the single measurement;
c. quantitatively three dimensional (3D) imaging the target in the single measurement;
d. concurrently determining a flow rate of a fluid and a concentration of one or more analytes, from the acquired optical
information and the 3D imaging in the single measurement; and

e. determining a rate of change of the one or more analyte concentrations in the target based on the determining of flow rate
of a fluid and a concentration of one or more analytes.

US Pat. No. 9,390,695

SYSTEMS, METHODS, AND APPARATUS TO SEARCH AUDIO SYNTHESIZERS USING VOCAL IMITATION

NORTHWESTERN UNIVERSITY, ...

1. A method comprising:
receiving an audio input with respect to a target sound;
extracting one or more features from the audio input to provide one or more examples for rating based on the audio input;
generating a query based on the audio input and the one or more rated examples;
providing one or more synthesizer suggestion results identified in a search based on the query;
evaluating the one or more results with respect to the target sound;
when one of the results matches the target sound, outputting synthesizer parameters associated with the result; and
when none of the results matches the target sound, refining the query for a second search based on feedback with respect to
the one or more results.

US Pat. No. 9,118,078

METHOD OF FORMING A FILM OF GRAPHITE OXIDE SINGLE LAYERS, AND APPLICATIONS OF SAME

NORTHWESTERN UNIVERSITY, ...

1. A method for the assembly of a film of graphite oxide single layers on a substrate, comprising the steps of:
(a) providing a trough, said trough containing a first water, the boundary between said first water and air being an air-water
interface;

(b) providing a solution, said solution comprising graphite oxide single layers, a second water, and a polar protic alcohol;
(c) applying said solution to said air-water interface to form a film of graphite oxide single layers at a first packing density,
said film of graphite oxide single layers at said first packing density more buoyant than said first water, said first packing
density defined as the ratio of the surface pressure of said film of graphite oxide single layers at said first packing density
to the unit area of said air-water interface;

(d) transversely compressing said film of graphite oxide single layers at said first packing density along a direction substantially
parallel to said air-water interface to form a film of graphite oxide single layers at a second packing density, said film
of graphite oxide single layers at said second packing density more buoyant than said first water, said second packing density
defined as the ratio of the surface pressure of said film of graphite oxide single layers at said second packing density to
the unit area of said air-water interface, said second packing density greater than said first packing density; and

(e) moving along a direction substantially perpendicular to said air-water interface at least a portion of said substrate
through said film of graphite oxide single layers at said second packing density to form said film of graphite oxide single
layers on said substrate,

wherein said film of graphite oxide single layers is formed on said substrate without use of a dissolved, adsorbed or covalently
grafted surface active agent.

US Pat. No. 9,815,764

HOMOCHIRAL METAL-ORGANIC FRAMEWORK WITH ENANTIOPURE PILLAR[5]ARENE ACTIVE DOMAINS

NORTHWESTERN UNIVERSITY, ...

1. A method of preparing a homochiral metal organic framework (MOF) consisting of (Sp)-P5A-MOF-1, comprising:
preparing a mixture of (Sp)-1 and Zn(NO3)2 in a solvent, wherein (Sp)-1 is the Sp-enantiomer structure of formula (I):


 and
heating the mixture at temperature of about 100° C. to form the homochiral metal organic framework (MOF) consisting of (Sp)-P5A-MOF-1.

US Pat. No. 9,624,320

MALEIC ANHYDRIDE FUNCTIONALIZATION OF POLYPROPYLENE VIA SOLID-STATE SHEAR PULVERIZATION

Northwestern University, ...

1. A method of preparing a functionalized polymer,
said method comprising:
providing a mixture comprising a polymer comprising a polypropylene component, a functionalization component comprising an
?, ?-unsaturated carboxy derived-moiety and a free-radical initiator component; and

applying a mechanical energy to said mixture through solid-state shear pulverization in the presence of cooling sufficient
to maintain said polymer in a solid state during said pulverization, said pulverization solventless and sufficient to graft
a said carboxy-derived moiety onto said polypropylene component, said pulverization providing a functionalized polymer.

US Pat. No. 9,416,106

2-AMINOPYRIDINE-BASED SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS

Northwestern University, ...

1. A compound selected from compounds of a formula
wherein R1 is selected from 6-aminopyridin-2-yl and 6-amino-4-methylpyridin-2-yl moieties; X is selected from CH2O, CH2CH2 and CH2OCH2 moieties; Y is selected from O and CH2 moieties; and n is an integer selected from 1 and 2, and salts thereof.

US Pat. No. 9,302,921

WATER DETOXIFICATION BY A SUBSTRATE-BOUND CATECHOLAMINE ADSORBENT

Northwestern University, ...

1. A method for removing one or more contaminants from water, the method comprising contacting the water with an adsorbent
comprising a polydopamine polymer, whereby the one or more contaminants are adsorbed to the polydopamine polymer and removed
from the water; and
regenerating the adsorbent by contacting the adsorbent with dilute acid, whereby the contaminants are removed from the adsorbent.

US Pat. No. 9,283,548

CERIA-SUPPORTED METAL CATALYSTS FOR THE SELECTIVE REDUCTION OF NOX

Northwestern University, ...

1. A catalyst fabricated by a method comprising:
contacting a substrate containing ceria with a first solution containing:
catalytic cations comprising transition metal cations, post-transition metal cations, or a combination thereof; and
at least one chelator; and
contacting the substrate with a second solution containing promoter cations comprising alkali metal cations, alkaline earth
metal cations, or a combination thereof,

wherein the catalytic cations undergo a first cycle-reduction during an initial temperature programmed reduction (TPR) up
to 550° C. at about twice the frequency at which catalytic cations in an otherwise identical catalyst, fabricated without
the at least one chelator, undergo a first-cycle reduction during an identical TPR.

US Pat. No. 9,638,778

METHODS AND SYSTEMS FOR IMPROVING SNR IN MULTI-SLICE MULTI-SEGMENT MAGNETIC RESONANCE IMAGING

Northwestern University, ...

1. A method for operating a Magnetic Resonance (MR) imaging system, the method comprising:
generating radio frequency (RF) excitation pulses in patient anatomy to provide subsequent acquisition of associated RF echo
data;

generating slice select magnetic field gradients for phase encoding and readout RF data acquisition in the patient anatomy;
acquiring a segment of a plurality of segments of k-space data for each of a plurality of slices of an imaged volume within
each of a plurality of cycles; and

causing, by a control processor, a RF signal generator and a gradient generator to change an order of the slices that the
segments of k-space data are acquired for between consecutive cycles of the plurality of cycles.

US Pat. No. 9,636,374

PH-SENSITIVE POLYMER-DRUG CONJUGATES FOR TARGETED DELIVERY OF THERAPEUTICS

Northwestern University, ...

1. A method of using a polymeric carrier component to affect efficacy of a therapeutic agent, said method comprising:
providing a therapeutic agent comprising a boronic acid moiety;
conjugating a polymeric carrier component with said therapeutic agent, said polymeric carrier component comprising repeating
lysine monomeric units, each said lysine monomeric unit coupled to a catecholic component and each said catecholic component
coupled to a said therapeutic agent, said conjugation via a reversible pH-sensitive bond between a dihydroxyphenyl moiety
of said catecholic component and said boronic acid moiety; and

introducing said conjugated polymeric carrier component to a cellular environment comprising a pH at least sufficient to dissociate
said therapeutic agent therefrom.

US Pat. No. 9,615,758

CONTRIBUTION OF OXIDATIVE STRESS TO AF ELECTROGRAMS

Northwestern University, ...

1. A method of targeting a region having reactive oxygen species-associated (ROS-associated) cardiac tissue for ablation in
a subject, comprising:
(a) performing at least one EGM analysis of a plurality of recorded atrial EGMs for a site in the region suspected of having
ROS-associated cardiac tissue;

(b) determining one or more correlations of at least one AF EGM characteristic to a region having ROS-associated cardiac tissue
from the plurality of recorded atrial EGMs for the site;

(c) determining a first outcome of executing step (b) and a second outcome of executing step (b) for the site based upon the
one or more correlations of at least one AF EGM characteristic to a region having ROS-associated tissue;

wherein the first outcome triggers a first decision to avoid ablation of the analysis region and the second outcome triggers
a second decision to perform ablation of the analysis region of the site,

wherein the one or more correlations of at least one AF EGM characteristic to a region suspected of having ROS-associated
cardiac tissue comprises a further correlation of Ca2+ cycling characteristics of underlying myocardium of the site.

US Pat. No. 9,600,115

HAPTIC DEVICE WITH CONTROLLED TRACTION FORCES

NORTHWESTERN UNIVERSITY, ...

1. A haptic device comprising
a substrate having a surface,
a first actuator that modulates a friction experienced by user's finger touching the substrate surface;
a second actuator that oscillates the substrate surface laterally, such that the combined effect of the first and second actuator
is a net shear force applied to the user's finger;

a finger position sensor that detects and measures location of the user's finger relative to the substrate surface, and
a control device that controls the first actuator and second actuator and varies the magnitude and direction of the net shear
force applied to the user's finger as a function of at least the measured location of the user's finger on the surface of
the substrate,

wherein a force field is created that acts upon the user's finger on the surface of the substrate.

US Pat. No. 9,256,086

ORGANIC ELECTRO-OPTIC MODULATORS WITH TRANSPARENT CONDUCTING ELECTRODES AND RELATED DEVICE STRUCTURES

Northwestern University, ...

1. A system for transmitting RF signals, said system comprising:
an electro-optic modulator for side conduction of voltage, said modulator comprising an optical waveguide component comprising
an organic core component and cladding thereabout and optically coupled thereto, said organic core component connected to
opposed co-planar metallic electrodes with top and bottom laterally-extending transparent conducting oxide electrode bridge
components, said cladding consisting of a bottom cladding component and two lateral cladding components co-planar with said
core component, each said lateral cladding component positioned between said core component and a said metallic electrode,
said waveguide component providing optical mode confinement in the horizontal direction; and

a switching voltage applied across said core component with said laterally-extending transparent conducting oxide electrode
bridge components.

US Pat. No. 9,186,103

SYSTEM AND METHOD FOR SPIN LOGIC

NORTHWESTERN UNIVERSITY, ...

1. A logic switching element, comprising:
a magnetoresistive element, the magnetoresistive element being formed of a magnetoresistive material and having first and
second terminals;

first and second conductors disposed in proximity to the magnetoresistive element, whereby a magnetic field generated by at
least one of the first and second conductors will affect the magneto resistive characteristic of the magnetoresistive element,
wherein the magnetoresistive element comprises a negative magnetoresistive element.

US Pat. No. 9,815,044

CERIA-SUPPORTED METAL CATALYSTS FOR THE SELECTIVE REDUCTION OF NOX

Northwestern University, ...

1. A method for fabricating a catalyst comprising:
contacting a substrate containing ceria with a solution containing catalytic cations; and
contacting the substrate with a solution containing promoter cations; wherein the catalytic cations consist of transition
metal cations, post-transition metal cations, or a combination thereof, and the promoter cations consist of alkali metal cations,
alkaline earth metal cations, or a combination thereof.

US Pat. No. 9,688,015

DEFORMATION-BASED MICRO SURFACE TEXTURING SYSTEM

Northwestern University, ...

1. A method for surface texturing a metallic or non-metallic material, comprising:
passing a sheet material having a sheet thickness in the range of about 20 ?m to about 1.5 mm through a roll gap formed between
opposing rolls, at least one of which has one or more micro surface protrusions and/or recesses, wherein the micro surface
depressions and/or recesses have a lateral dimension of about 1 ?m to about 10 mm and a vertical dimension of about 1 ?m to
about 10 mm; and

forming one or more micro surface depressions and/or protrusions in the surface by said micro surface protrusion and/or recess
plastically deforming the surface by rolling action.

US Pat. No. 9,585,975

MRI CONTRAST AGENTS

Northwestern University, ...

1. A composition comprising an MRI contrast agent, wherein the MRI contrast agent is

US Pat. No. 9,472,597

SYSTEMS, APPARATUSES AND METHODS FOR CONVERTING LIGHT WAVELENGTHS

Northwestern University, ...

1. An apparatus for converting light having a first wavelength to a light having a second wavelength, the apparatus comprising:
an interband light detector comprising
an interband absorber layer configured to absorb light having the first wavelength to generate electron-hole pairs;
a barrier and trap layer over the absorber layer, wherein the barrier and trap layer is configured to trap one of a hole and
an electron of the electron-hole pairs and configured to form a barrier to the other one of the hole and the electron of the
electron-hole pairs to result in light amplification; and

an injector layer over the barrier and trap layer, the injector layer configured to inject either electrons or holes into
the interband absorber layer via the barrier;

a light emitting device configured to emit light having the second wavelength; and
a connector layer between the injector layer and the light emitting device, the connector layer configured to supply other
electron-hole pairs and to supply either electrons or holes of the other electron-hole pairs to the injector layer and to
supply the other of electrons or holes of the electron-hole pairs to the light emitting device.

US Pat. No. 9,371,455

METHOD OF COATING 3,4-DIHYDROXYPHENYLALANINE-BASED (DOPA) COATINGS ONTO SUBSTRATES FOR ADHERING METAL FROM FLUIDS ONTO THE SUBSTRATE

Northwestern University, ...

1. A method of reducing amounts of metal in a fluid comprising the steps of:
a) contacting at least a portion of a substrate with an alkaline, aqueous solution under oxidative conditions, the solution
comprising a surface-modifying agent according to Formula I:


wherein each of R1, R2, R3, R4 and R5 is independently selected from the group consisting of a thiol, a primary amine, a secondary amine, a nitrile, an aldehyde,
an imidazole, an azide, a halide, a polyhexamethylene dithiocarbonate, a hydrogen, a hydroxyl, a carboxylic acid, an aldehyde,
a carboxylic ester or a carboxamide, provided at least one of R1, R2, R3, R4 and R5 is not a hydrogen atom;

wherein x ranges from 0 to 10 and wherein y ranges from 0 to 10, provided that x or y is at least 1; and
b) contacting the surface-modified substrate with a reactive moiety, wherein the reactive moiety reacts with and is bound
to the surface-modified substrate forming a moiety-modified substrate

c) positioning the moiety-modified substrate in a fluid with metal,
whereby the moiety-modified substrate binds to at least a portion of the metal, thereby reducing the amounts of metal in the
fluid.

US Pat. No. 9,216,939

METAL-ORGANIC FRAMEWORK MATERIALS WITH ULTRAHIGH SURFACE AREAS

NORTHWESTERN UNIVERSITY, ...

22. A metal organic framework (MOF) material comprising three types of cuboctahedron cages fused to provide continuous channels,
wherein the MOF material comprises a Brunauer-Emmett-Teller (BET) surface area greater than 10,500 m2/g.
US Pat. No. 9,181,577

TREATMENT OF CHRONIC PELVIC PAIN SYNDROME

Northwestern University, ...

1. A composition for the treatment of chronic pelvic pain syndrome (CPPS), comprising:
a) a mast cell stabilizer; and
b) a histamine receptor 1 antagonist and/or a histamine receptor 2 antagonist;
wherein the composition is formulated for administration by a route other than inhalation.

US Pat. No. 9,107,985

WOUND TREATMENT CONTAINMENT APPARATUS

NORTHWESTERN UNIVERSITY, ...

13. A system for wound treatment comprising:
a) a base element comprising a top and bottom, wherein the bottom is:
i) conformable to contours of a non-planar surface, and
ii) securable to a surface of a body or to a wound-proximal membrane element residing upon the surface of a body;
b) an upper housing element, connectable to the top of said base element by an interlocking mechanism, by magnets, or by a
screw-in mechanism, wherein said upper housing element is less flexible than said base element and comprises at least first
and second port elements;

c) a material introduction component, connected to said first port element; and
d) a fluid suction component, connected to said second port element;wherein the base element is differentially compressible so that the bottom is conformable to contours of a non-planar surface
while the top is attached to the less flexible upper housing element.

US Pat. No. 9,079,764

METHODS FOR PREPARATION OF CONCENTRATED GRAPHENE COMPOSITIONS AND RELATED COMPOSITE MATERIALS

Northwestern University, ...

1. A method for concentrating a graphene medium, said method comprising:
exfoliating a graphene source material with a medium comprising an organic solvent selected from ethanol and dimethylformamide,
and an ethyl cellulose;

contacting at least a portion of said exfoliated graphene medium with a terpineol; and
hydrating said graphene-terpineol medium to concentrate exfoliated graphene in said terpineol.

US Pat. No. 10,109,050

SPATIOTEMPORAL BACKGROUND PHASE CORRECTION FOR PHASE CONTRAST VELOCITY ENCODED MRI

Siemens Healthcare GmbH, ...

1. A computer-implemented method for performing spatiotemporal background phase correction for phase contrast velocity encoded magnetic resonance imaging, the method comprising:performing, by a magnetic resonance imaging scanner, a phase contrast magnetic resonance imaging scan of a region of interest within a patient to yield a complex image of the region of interest on a display device;
calculating a plurality of filter cut-off frequencies based on physiological limits associated with the patient;
creating a spatiotemporal filter based on the plurality of filter cut-off frequencies;
applying the spatiotemporal filter to the complex image to yield a low-pass filtered complex image; and
performing complex division using the complex image and the low-pass filtered complex image to yield a corrected image of the region of interest on the display device.

US Pat. No. 10,090,565

POLYMER FUNCTIONALIZED GRAPHENE OXIDE AND THERMALLY RESPONSIVE ION PERMEABLE MEMBRANES MADE THEREFROM

Northwestern University, ...

1. A thermally responsive material comprising:a substrate; and
poly(3-(N-2-methacryloyloxyethyl-N,N-dimethyl)ammonatobutane-sulfonate molecules covalently bonded to the substrate, the polymer molecules having an upper-critical solution temperature in a non-aqueous solution, the polymer molecules characterized in that they phase separate from the non-aqueous solution at temperatures below the upper-critical solution temperature, but undergo a reversible conformational change at the upper-critical solution temperature such that they are miscible in the non-aqueous solution at temperatures above the upper-critical solution temperature;
wherein the thermally responsive material is porous and electrically insulating.

US Pat. No. 9,809,556

TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Northwestern University, ...

1. A compound selected from compounds of a formula
wherein each of R1-R4 is independently selected from H, alkyl, cycloalkyl, alkylsulfonyl, alkylcarbonyl, aryl, arylalkyl, alkenylalkyl and alkynylalkyl
moieties; each of R?1-R?4 is independently selected from H, alkyl, amino, alkylamino, alkylsulfonyl, alkylcarbonyl, alkoxy, alkoxycarbonyl, cyano, and
halo moieties; m is an integer selected from 0-3, and n is an integer selected from 1-3; and salts, tautomers and combinations
thereof.
US Pat. No. 9,732,392

MODULAR SENSOR ARCHITECTURE FOR CELL BASED BIOSENSORS

Northwestern University, ...

1. A composition comprising:
i) first and second exogenous sensors wherein said first exogenous sensor comprises:
a) a first ligand binding domain,
b) a transmembrane domain,
c) a protease cleavage site, and
d) a functional domain;
and wherein said second exogenous sensor comprises:
e) a second ligand binding domain,
f) a transmembrane domain, and
g) a protease domain; and
ii) a cell, wherein said first and second exogenous sensors are located in the cell membrane such that the first and second
ligand binding domains are located outside said cell; and wherein said protease cleavage site and said functional domain are
located inside said cell; and
wherein said first and second ligand binding domains bind the same ligand outside said cell, andwherein said first and second exogenous sensors are configured such that said protease domain will cleave said protease cleavage
site when said first and second ligand binding domains bind said same ligand outside said cell.

US Pat. No. 9,613,879

ULTRALOW POWER CARBON NANOTUBE LOGIC CIRCUITS AND METHOD OF MAKING SAME

NORTHWESTERN UNIVERSITY, ...

1. A complementary metal-oxide-semiconductor (CMOS) logic device formed with single-walled carbon nanotubes (SWCNTs), comprising:
at least one p-type metal-oxide-semiconductor (PMOS) thin-film transistor (TFT) formed with the SWCNTs, wherein each of the
at least one PMOS TFT has a gate, a source and a drain; and

at least one n-type metal-oxide-semiconductor (NMOS) TFT formed with the SWCNTs, wherein each of the at least one NMOS TFT
has a gate, a source and a drain,

wherein the gate of each of the at least one PMOS TFT and the gate of each of the at least one NMOS TFT is configured to alternatively
receive at least one input voltage;

wherein at least one of the drain of the at least one PMOS TFT and the drain of the at least one NMOS TFT is configured to
output an output voltage VOUT;

wherein the gate of each of the at least one PMOS TFT and the gate of each of the at least one NMOS TFT respectively comprises
a local metallic gate structure formed of a metal;

wherein a threshold voltage of the at least one PMOS TFT and a threshold voltage of the at least one NMOS TFT are symmetric;
and

wherein each of the at least one NMOS TFT is chemically doped with benzyl viologen.

US Pat. No. 9,593,069

CYCLOHEXANE-1,3-DIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Northwestern University, ...

1. A method comprising administering to a subject suffering from or susceptible to amyotrophic lateral sclerosis (ALS) an
effective amount of a compound of a formula:
or a pharmaceutically acceptable salt thereof, wherein:
each R is independently hydrogen, halogen, optionally substituted C1-6 aliphatic, optionally substituted phenyl, optionally substituted benzyl, or two R on the same carbon are taken together to
form a 5-6 membered saturated, partially saturated, or aryl ring having 1-3 heteroatoms independently selected from nitrogen,
oxygen, and sulfur;

R1, R2, and R3 are each independently —R, —OR, —SR, —S(O)R, —SO2R, —OSO2R, N(R)2, —NRC(O)R, —NRC(O)(CO)R, —NRC(O)N(R)2, —NRC(O)OR, —N(R)S(O)R, —N(R)SO2R, —N(R)SO2OR, —C(O)R, —C(O)OR, —OC(O)R, —OC(O)OR, —C(O)N(R)2, —OC(O)N(R)2, or an optionally substituted 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring having 0-4 heteroatoms
independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered saturated, partially unsaturated,
or aryl bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;

L is a valence bond or a bivalent saturated or partially unsaturated, branched or unbranched C1-10 hydrocarbon chain, wherein 1-3 methylene units of L are optionally and independently replaced by —NR—, —N(R)C(O)—, —C(O)N(R)—,
—N(R)SO2—, —SO2N(R)—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —S—, —S(O)— or —SO2—, and wherein L is optionally substituted with 1-4 R groups, wherein two R on the same carbon or on adjacent carbons are
optionally taken together to form a 3-6 membered saturated spirocyclic or fused monocyclic ring containing 0-2 heteroatoms
independently selected from nitrogen, oxygen, and sulfur;

Ring A is a 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring optionally containing 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur;

m is 0-5;
each Ra is independently —R, —OR, —SR, —S(O)R, —SO2R, —OSO2R, N(R)2, —NRC(O)R, —NRC(O)(CO)R, —NRC(O)N(R)2, —NRC(O)OR, —N(R)S(O)R, —N(R)SO2R, —N(R)SO2OR, —C(O)R, —C(O)OR, —OC(O)R, —OC(O)OR, —C(O)N(R)2, —OC(O)N(R)2, or:

two Ra on adjacent carbons are taken together to form an optionally substituted 3-12 membered saturated, partially unsaturated, or
aryl fused ring containing 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or:
at least one Ra is independently
wherein Q is a valence bond or a bivalent optionally substituted saturated or partially unsaturated, branched or unbranched
C1-10 hydrocarbon chain, wherein 1-3 methylene units of Q are optionally and independently replaced by —NR—, —N(R)C(O)—, —C(O)N(R)—,
—N(R)SO2—, —SO2N(R)—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —S—, —S(O)— or —SO2—;
Ring B is a 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring optionally containing 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur;

n is 0-5;
each Rb is independently —R, —OR, —SR, —S(O)R, —SO2R, —OSO2R, N(R)2, —NRC(O)R, —NRC(O)C(O)R, —N(R)C(O)N(R)2, —N(R)C(O)OR, —N(R)S(O)R, —N(R)SO2R, —N(R)SO2OR, —C(O)R, —C(O)OR, —OC(O)R, —OC(O)OR, —C(O)N(R)2, —OC(O)N(R)2; and

R4 and R4? are each independently R, or R4 and R4? are taken together to form an alkenylene optionally substituted with one or two Rc groups; wherein

each Rc is independently —R, —OR, —CN, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, —N(R)2, or wherein Rc is a 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring optionally containing 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur, or an 8-10 membered saturated, partially unsaturated, or aryl bicyclic ring optionally
containing 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein Rc is optionally substituted with p occurrences of Rd, wherein:

p is 0 to 5; and
each Rd is independently —R, —OR, —CN, —C(R)3, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2, thereby reducing the severity or incidence of one or more symptoms of ALS or delaying onset thereof.

US Pat. No. 9,527,819

PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS

NORTHWESTERN UNIVERSITY, ...

1. A compound of Formula Ib:
wherein:
R1 is a substituted amino group;

R2 is cycloalkyl, cycloalkenyl, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, sulfonyl, sulfinyl,
sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, ureido, cyano, halo, silyl, silyloxy, silylalkyl,
silylthio, carboxyl, carbonyl, carbamoyl, or carboxamide,

wherein heteroaryl is a fully unsaturated heteroatom-containing ring-shaped aromatic radical having one, two or three rings
attached in a pendant manner or fused, having 5 or 6 members in each ring and having at least one heteroatom selected from
carbon, nitrogen, sulfur and oxygen, and heterocyclic is a saturated or partially saturated heteroatom-containing ring-shaped
radical having one, two or three rings attached in a pendant manner or fused, having 3 to 6 members in each ring and having
at least one heteroatom selected from carbon, nitrogen, sulfur and oxygen, and each of heteroaryl and heterocyclic is optionally
substituted by halogen, hydroxy, thio, nitro, amino, ketone, aldehyde, ester, amide, alkyl, aryl, or cycloalkyl,

R3 is hydrogen, and

R4, R5 and R6 are independently hydrogen, alkyl, alkoxy, halo or nitro;

or a pharmaceutically acceptable salt thereof.
US Pat. No. 9,469,875

METHODS FOR DETECTION OF DEPRESSIVE DISORDERS

Northwestern University, ...

1. A composition comprising a panel of between 4 and 40 cDNAs, wherein at least four of the cDNAs are selected from the consisting
of ADCY3, ASAH1, FAM46A, IGSF4A/CADM1, MARCKS, NAGA, TLR7, ATP11C, CD59, CDR2 , CMAS, PSME1and DGKA.

US Pat. No. 9,449,731

MODULAR SUPRAMOLECULAR APPROACH FOR CO-CRYSTALLIZATION OF DONORS AND ACCEPTORS INTO ORDERED NETWORKS

Northwestern University, ...

1. An organic charge-transfer (CT) co-crystal consisting essentially of an electron acceptor molecule (A) and an electron
donor molecule (D), such that one of (A) and (D) is incorporated into the other of (A) and (D) through molecular linkages
in a solvent system to form a co-crystalline supramolecular network, wherein one or more of the molecular linkages between
the (A) and (D) uses adaptive intermolecular recognition to form the one or more molecular linkages, the co-crystal characterized
by having a crystal superstructure comprising a mixed stack lattice (DADADA) and a topological hydrogen-bonded network, said
organic CT co-crystal wherein A is selected from the group consisting of

and D is selected from the group consisting of

US Pat. No. 9,327,120

SYSTEM AND METHOD FOR ANIMAL-HUMAN NEURAL INTERFACE

NORTHWESTERN UNIVERSITY, ...

1. A method for transmitting neural data extracted from an electrical signal of a non-human mammal to a human, comprising:
exposing the non-human mammal to sensory stimuli;
recording the electrical signal of the non-human mammal responsive to the sensory stimuli, wherein the electrical signal is
in the form of sequences of pulses or pulse trains encoding frequency information of the non-human mammal;

processing the recorded electrical signal and converting the processed electrical signal into a digital signal;
transmitting the digital signal; and
receiving and converting the digital signal into a sensory output perceptible to the human, and applying the sensory output
to the human,

wherein the step of receiving and converting the digital signal into the sensory output perceptible to the human, and applying
the sensory output to the human is performed with a cochlear implant implanted into the human.

US Pat. No. 9,278,852

NANOTIPPED DEVICE AND METHOD

Northwestern University, ...

1. A method of dispensing material, comprising supplying material through a microchannel in a cantilever extending from a
substrate to a material dispensing tip on the cantilever and dispensing the material from the material dispensing tip on a
surface, including imparting a bending motion to the cantilever by energizing a piezoelectric film actuator, a thin film thermal
actuator, or a magnetic film actuator disposed on the cantilever.

US Pat. No. 9,212,144

2-AMINOQUINOLINE-BASED COMPOUNDS FOR POTENT AND SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITION

Northwestern University, ...

1. A compound of a formula
wherein n is an integer selected from 1-2; m is an integer selected from 1-3; R is selected from chloro and fluoro groups;
and o is an integer selected from 0-2, or a salt thereof.

US Pat. No. 9,054,247

SINGLE-PHOTON NANO-INJECTION DETECTORS

Northwestern University, ...

1. A photon detector comprising a semiconductor heterostructure, the semiconductor heterostructure comprising:
(a) a photon absorber comprising a layer of photon absorbing material which absorbs photons to generate electron-hole pairs;
and

(b) a carrier injector adapted to inject carriers of a first type into the photon absorber, the carrier injector comprising:
(i) a layer of carrier injecting material capable of generating the carriers of the first type upon the application of a bias
voltage; and

(ii) a carrier trap disposed between the layer of carrier injecting material and the layer of photon absorbing material, the
carrier trap comprising a layer of potential barrier-forming material which forms a potential trap for carriers of a second
type;

wherein the photon absorbing material, the carrier injecting material and the potential barrier-forming material have a band
structure with a type II band alignment;

further wherein the photon detector is characterized by at least one of: the ability to detect a single-photon with a quantum
efficiency of at least 50%; a bandwidth of at least 1 GHz; or a dark count rate of no greater than 1 kHz at a temperature
in the range from about 150K to 298K; and further wherein the layer of carrier injecting material comprises a first region
having a first dopant concentration and a second region disposed between the first region and the carrier trap, wherein the
second region has a dopant concentration that is lower than the first dopant concentration.

US Pat. No. 10,081,668

MODIFIED PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) PEPTIDES AND USES THEREOF FOR TREATING NEOVASCULAR DISEASES, INFLAMMATORY DISEASES, CANCER, AND FOR CYTOPROTECTION

Northwestern University, ...

1. A modified peptide comprising an N-terminal carboxyl group and a modified amino acid sequence as follows:Z-B-X-AA0-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-AA9-AA10-Y  (SEQ ID NO:14)wherein:AA0 is absent or present, and when AA0 is present AA0 is selected from the group consisting of sarcosyl, and Gly;
AA1 is absent or present, and when AA1 is present AA1 is selected from the group consisting of sarcosyl and Gly;
AA2 is Tyr;
AA3 is Asp or Asn;
AA4 is Leu, Ile, or Val;
AA5 is Tyr or Phe;
AA6 is Arg;
AA7 is Val or Pro;
AA8 is present or absent, and when AA8 is present AA8 is selected from the group consisting of Arg, Pro, and Gln;
AA9 is present or absent, and when AA9 is present AA9 is selected from the group consisting of Ser and Ala;
AA10 is absent or present and when AA10 is present AA10 is selected from the group consisting of Ser, and Ser-Thr,
X is absent or present, and when X is present X is selected from the group consisting of acetyl, butyryl, hexanoyl, methoxy-PEG(n)CO, hydroxy-PEG(n)CO, amino-PEG(n)CO, and sarcosyl-amino-PEG(n)CO, where n is 3-13, and X is in an amide bond to an amino terminus of AA0, AA1, or AA2;
B is absent or present, and when B is present B is a di-carboxylic acid containing from 4-8 carbon atoms, which may be straight-chain or branched, and B is in a half-amide bond to an amino terminus of X, or B is in a half-amide bond to an amino terminus of AA0 when X is absent, or B is in a half-amide bond to an amino terminus of AA1 when X and AA0 are absent, or B is in a half-amide bond to an amino terminus of AA2 when X, AA0 and AA1 are absent; and B may end in a free carboxyl group, or this otherwise free carboxyl group may be in an ester bond to a hydroxyl group of Z;
wherein if B is present X is absent, and wherein if X is present B is absent;
Z is absent or present if B is present, Z is absent if X is present, and when Z is present Z is joined through an ester bond to a carbonyl group of B, and Z is selected from the group consisting of: primary or secondary hydroxyl groups of sugar monomers present on a polymeric carbohydrate carrier; hydroxyl groups of a hydroxyl terminal dendrimer; and primary or secondary hydroxyl groups of acyclic or cyclic amino alcohols having between 4 and 6 carbon atoms and a single primary or secondary amine that is protected through an amide bond or a carbamate bond; and
Y is an amide or a substituted amide selected from the group consisting of amide or ethylamide.
US Pat. No. 9,980,992

LACTOBACILLUS WITH DECREASED LIPOTEICHOIC ACID TO REDUCE INFLAMMATORY RESPONSES

Northwestern University, ...

1. A composition comprising a bacterium having a decreased display of lipoteichoic acid (LTA) on the surface of said bacterium, wherein the bacterium comprises a deletion or substitution of at least one base pair of a polynucleotide encoding a phosphoglycerol transferase such that the expression of the phosphoglycerol transferase is decreased compared to a control bacterium,wherein said polynucleotide encoding the phosphoglycerol transferase comprises a nucleotide sequence having at least 85% sequence identity to the nucleic acid sequence as set forth in SEQ ID NO:1,
wherein the bacterium does not contain an antibiotic selection marker within said polynucleotide encoding the phosphoglycerol transferase, and
wherein said bacterium is present in a concentration of about 105 CFU/gram to about 1012 CFU/gram or at about 105 CFU/ml to about 1012 CFU/ml.

US Pat. No. 9,780,791

EMITTER-COUPLED SPIN-TRANSISTOR LOGIC

Northwestern University, ...

15. A logic circuit, comprising:
a spin-transistor; and
a first control wire routed alongside the spin-transistor, the first control wire for carrying a current near the spin-transistor
to create a magnetic field that affects amplification of the spin-transistor.

US Pat. No. 9,687,582

NEGATIVE-SWELLING AND EXCEPTIONALLY ROBUST ADHESIVE HYDROGELS

Northwestern University, ...

1. A method for making a non-swelling medical adhesive comprising a hydrogel in a PBS solution at physiological temperature,
the method comprising:
(a) contacting a composition comprising a catechol-modified poly(ethylene oxide)-poly(propylene oxide) block copolymer having
four linear PPO-PEO arms emanating from a tetrafunctional ethylenediamine core with a biocompatible oxidant in a PBS solution
at room temperature or below, whereby the catechol-modified poly(ethylene oxide)-poly(propylene oxide) block copolymer is
chemically cross-linked to form a hydrogel;

(b) increasing the temperature of the resulting hydrogel in the PBS solution to physiological temperature; and
(c) thermally equilibrating the hydrogel at physiological temperature, whereby the hydrogen exhibits no or negative swelling
after at least one day in PBS solution at 37° C.

US Pat. No. 9,636,329

METHODS OF TREATING CANCER WITH GLUT INHIBITORS AND OXIDATIVE PHOSPHORYLATION INHIBITORS

Northwestern University, ...

1. A method comprising: (a) requesting a test providing results of an analysis to detect GLUT4 in cancer cells from a biological
sample obtained from a patient diagnosed with multiple myeloma, chronic lymphocyte leukemia (CLL), diffuse large B-cell lymphoma
(DLBCL), mantle cell lymphoma, neuroblastoma, breast cancer, or ovarian cancer, and (b) administering a GLUT4 inhibitor and
an OXPHOS inhibitor to the patient if an elevated level of the GLUT4 in the cancer cells is detected or if the GLUT4 is mislocalized
in the cancer cells, wherein the GLUT4 inhibitor is selected from ritonavir and indinavir and the OXPHOS inhibitor is selected
from metformin, phenformin, buformin, and pharmaceutically acceptable salts thereof.

US Pat. No. 9,513,260

METHODS, SYSTEMS AND APPARATUS OF AN ALL-OPTICS ULTRASOUND SENSOR

NORTHWESTERN UNIVERSITY, ...

1. A transparent ultrasonic transducer comprising:
a transparent substrate; and
a transparent optical resonator positioned on the transparent substrate, the transparent optical resonator to facilitate excitation
of a biological sample and to receive acoustic emission from the biological sample triggered by the excitation,

wherein the transducer is coupled with an optical imaging instrument to facilitate optical and acoustic imaging of the biological
sample, and wherein the optical imaging instrument comprises an optical microscope, and wherein the coupling of the transducer
with the optical microscope converts the microscope into a photoacoustic microscope for simultaneous optical and acoustic
imaging.

US Pat. No. 9,499,439

HIGHLY DISPERSED CARBON NANOTUBE-REINFORCED CEMENT-BASED MATERIALS

Northwestern University, ...

1. A cured nanocomposite cementitious composition, comprising:
cement;
about 0.02% to about 0.1% multiwalled carbon nanotubes, by weight of the cement; and
about 0.1 to 0.4% polycarboxylate based superplasticizer, by weight of the cement;
wherein the cured nanocomposite cementitious material comprises calcium-silicate-hydrates; and
further wherein the cured nanocomposite cementitious material has a Young's modulus that is at least 15% higher than that
of the plain cured cement at the age of 28 days and further wherein the nanocomposite cementitious material exhibits a modified
nanostructure so that the average values of stiffness and hardness of the calcium-silicate-hydrates, as determined by nanoindentation
tests, are higher compared to the plain cured cement.

US Pat. No. 9,320,719

MULTIFUNCTIONAL METAL NANOPARTICLES HAVING A POLYDOPAMINE-BASED SURFACE AND METHODS OF MAKING AND USING THE SAME

Northwestern University, ...

1. A method for treating cancer comprising administering to a patient having cancer cells one or more nanoparticles comprising:
(a) a metallic core consisting essentially of gold and having a length along each axis of from 1 to 100 nanometers;
(b) a coating comprising polydopamine disposed on at least part of the surface of the metallic core; and
(c) one or more cetuximab anti-cancer cell surface receptor antibodies;
whereby the one or more nanoparticles target the cancer cells and the cancer is effectively treated, and wherein the cancer
is selected from the group consisting of metastatic colorectal cancer, head and neck cancer, and epidermal growth factor receptor
(EGFR)-expressing breast cancer.

US Pat. No. 9,221,064

SORTING TWO-DIMENSIONAL NANOMATERIALS BY THICKNESS

Northwestern University, ...

1. A method for separating planar nanomaterials by thickness, the method comprising:
centrifuging a transition metal dichalcogenide nanomaterial composition in contact with an aqueous fluid medium comprising
a density gradient, wherein the transition metal dichalcogenide nanomaterial composition comprises one or more surface active
components and a polydisperse population of planar transition metal dichalcogenide nanomaterials which is polydisperse at
least with respect to thickness and has a mean thickness on the order of nanometers; and

separating the transition metal dichalcogenide nanomaterial composition into two or more separation fractions each comprising
a subpopulation of planar transition metal dichalcogenide nanomaterials from the polydisperse population, wherein the subpopulation
of planar transition metal dichalcogenide nanomaterials in at least one of the two or more separation fractions has a mean
thickness that is less than the mean thickness of the polydisperse population.

US Pat. No. 9,066,822

VACUUM PUMP SYSTEMS FOR PROSTHETIC LIMBS AND METHODS OF USING THE SAME

NORTHWESTERN UNIVERSITY, ...

1. A hybrid pump system that includes a prosthetic device that is adapted for suspension from a transfemoral residual limb
comprising:
a prosthetic device having a transfemoral receiving socket and a knee joint;
a mechanically activated pump having pumping action that requires a mechanical input via movement of the prosthetic device;
a separate electrically activated pump having an electrical power source and pumping action that requires an electrical input
from the electrical power source;

the mechanically activated pump and electrically activated pump being connected within a fluid circuit that evacuates air
from the transfemoral limb receiving socket;

wherein the mechanically activated pump is positioned between the transfemoral limb receiving socket and the knee joint;
wherein the mechanically activated pump further comprises a first compression member coupled to a second compression member
and a compressible bladder disposed between the first and second compression members; and

wherein the mechanically activated pump further comprises coupling elements that engage and couple together the first and
second compression members, and wherein all of the coupling elements are disposed about an outer perimeter of the compressible
bladder.

US Pat. No. 9,909,181

BIOMARKERS FOR POST-TRAUMATIC STRESS STATES

NORTHWESTERN UNIVERSITY, ...

1. A panel of biomarkers consisting of an isolated set of 100 or fewer full-length cDNA biomarkers, wherein said isolated
set includes SERPINB1, LILRB3, and GLRX full-length cDNA biomarkers.

US Pat. No. 9,802,818

SORTING PROCESS OF NANOPARTICLES AND APPLICATIONS OF SAME

NORTHWESTERN UNIVERSITY, ...

1. A method for sorting nanoparticles, comprising:
(a) preparing an aqueous iodixanol density gradient medium filled in at least one centrifugal tube, wherein the aqueous iodixanol
density gradient medium is formed of about 30%-60% weight per volume iodixanol;

(b) dispersing nanoparticles into an aqueous solution to form a suspension of the nanoparticles, wherein each nanoparticle
comprises one or more gold cores and a silica shell encapsulating the one or more gold cores, wherein the shell is formed
such that the nanoparticles are dispersed in the aqueous solution without need for functionalization or surfactants;

(c) layering the suspension of the nanoparticles on the top of the aqueous iodixanol density gradient medium in the at least
one centrifugal tube;

(d) centrifuging the layered suspension of the nanoparticles at a predetermined speed with a centrifugal force of about 500
g for a predetermined period of time about 10 minutes to form a gradient of fractions of the nanoparticles in the at least
one centrifugal tube by sedimentation coefficients of the nanoparticles in a transient centrifugal regime so as to sort the
nanoparticles according to their sedimentation coefficients,

wherein the sedimentation coefficient of a fraction of the nanoparticles satisfies with the relationship of:

where m is a total nanoparticle mass of the fraction, ?s and ?p are respectively densities of the aqueous iodixanol density gradient medium and the fraction of the nanoparticles, and f is
a frictional coefficient that depends on a shape of the fraction of the nanoparticles and a viscosity of the aqueous iodixanol
density gradient medium;

wherein each fraction comprises nanoparticles in a respective one of aggregation states of the nanoparticles;
wherein each aggregation state is a monomer state or a cluster state that ranges from dimers to dodecamers; and
wherein the nanoparticles are separated in the at least one centrifugal tube according to their sedimentation coefficients
so that a fraction of the nanoparticles in the monomer state is in a top portion of the at least one centrifugal tube and
fractions of the nanoparticles in the cluster state that ranges from dimers to dodecamers are subsequently underneath the
fraction of the nanoparticles in the monomer state in the at least one centrifugal tube; and

(e) collecting each fraction of the nanoparticles from the at least one centrifugal tube.

US Pat. No. 9,728,636

SYSTEM AND METHOD FOR THRESHOLD LOGIC WITH ELECTROSTATICALLY FORMED NANOWIRE TRANSISTORS

NORTHWESTERN UNIVERSITY, ...

1. A threshold logic gate, comprising:
an electrostatically formed nanowire transistor, where the electrostatically formed nanowire transistor includes multiple
input gates to control a flow of current;

a pull-up device;
an output terminal between the electrostatically formed nanowire transistor and the pull-up device; and
supply voltage terminals at opposite ends of the pull-up device and the electrostatically formed nanowire transistor, where
the multiple input gates are configured to switch the electrostatically formed nanowire transistor based on a comparison of
a weighted sum of binary input voltages to a threshold value which results in at least one of less area, lower power, or higher
speed.

US Pat. No. 9,324,146

PHOTOMETRIC AND RADIOMETRIC CALIBRATION USING OPTICAL FEEDBACK

NORTHWESTERN UNIVERSITY, ...

1. A method of calibrating a camera and a display, the method comprising:
dithering between a first display pixel value and a second display pixel value to create a light source from the display;
capturing the light source using the camera via a plurality of photographs taken by the camera, each photograph comprising
a plurality of camera pixels;

determining a camera response by measuring plurality of camera quantization levels associated with the plurality of camera
pixels based on the first display pixel value and the second display pixel value; and

determining a display response based on the plurality of camera quantization levels, the display response comprising a plurality
of luminance output values of the display.

US Pat. No. 9,283,671

TRANSLATIONAL PARALLEL MANIPULATORS AND METHODS OF OPERATING THE SAME

NORTHWESTERN UNIVERSITY, ...

1. A translational parallel manipulator comprising:
a fixed platform including three guide members, wherein the three guide members include first ends and second ends, and wherein
the first ends of the three guide members are all coupled to each other and the second ends of the three guide members are
all spaced-apart from each other;

a movable platform spaced-apart from the fixed platform; and
three serial subchains coupled between the three guide members and the movable platform;
wherein each of the three serial subchains include:
a first prismatic joint;
a first revolute joint;
a second prismatic joint; and
a second revolute joint;
where the second revolute joints of the three serial subchains are coupled directly to the movable platform and rotational
axes of the second revolute joints intersect each other at a point on the movable platform.

US Pat. No. 9,122,325

TOUCH INTERFACE DEVICE AND METHOD FOR APPLYING CONTROLLABLE SHEAR FORCES TO A HUMAN APPENDAGE

NORTHWESTERN UNIVERSITY, ...

1. A touch interface device comprising: a touch surface; an actuator coupled with the touch surface and that subjects the
touch surface to vibrations along one or more axes of the touch surface; and an electrode coupled with the touch surface and
that imparts electrostatic forces in a direction normal to the touch surface on one or more appendages of a human operator
that engage the touch surface when an alternating electric current is conveyed to the electrode, wherein the electrostatic
forces vary in time and frequency, wherein the vibrations of the touch surface by the actuator and the electrostatic forces
provided by the electrode each have a frequency and the respective frequencies are synchronized with one another to generate
and control a magnitude and a direction of a persistent shear force applied to the one or more appendages that engage the
touch surface and that is felt by the one or more appendages as a pushing force that is oriented laterally relative to the
touch surface, and wherein the frequencies of said vibrations and said electrostatic forces are greater than the response
bandwidth of vibration sensitivity of the one or more appendages in touch.

US Pat. No. 9,101,612

SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF

Northwestern University, ...

1. A compound represented by:
wherein
R4 is H;

R1 is benzyl;

R5 is


R6 is


R2 is H or CH3,

R3 is H or CH3, and stereoisomers, N-oxides or pharmaceutically acceptable salts thereof.

US Pat. No. 9,096,689

METHODS AND COMPOSITIONS FOR INHIBITING ANGIOGENESIS

NORTHWESTERN UNIVERSITY, ...

1. A composition comprising an isolated peptide attached to a non-amino acid chemical moiety, wherein said peptide:
i) consists of the amino acid sequence in SEQ ID NO:2;
ii) consists of the amino acid sequence in SEQ ID NO: 11;
iii) consists of the amino acid sequence in SEQ ID NO: 61; or
iv) consists of the amino acid sequence in SEQ ID NO: 102; and
wherein said non-amino acid chemical moiety is a fluorescent compound or a targeting carrier.

US Pat. No. 10,091,468

SYSTEM AND METHOD FOR TRACKING CONTENT IN A MEDICINE CONTAINER

Northwestern University, ...

1. A system, comprising:a medicine container including a bottle and a cap;
a controller located in the medicine container, the controller connected with an image sensor to capture an image of a content in the medicine container and a scale to measure a weight of the content in the medicine container, the controller configured to process the image of the content and the weight of the content contained in the bottle;
an inertial measurement unit connected with the controller, the inertial measurement unit configured to detect a position of the medicine container, the controller configured to process the position information to ensure that the container is located in an upright position before the weight measurement is considered; and
a communication element connected with the controller, the communication element to send at least one of the image of the content and the weight of the content to at least one of a communication device and a server.

US Pat. No. 10,040,799

SUBSTITUTED 4-METHYL-PYRROLO[1,2-A]PYRIMIDINE-8-CARBOXAMIDE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY

Northwestern University, ...

1. A method for treating Gaucher's disease in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a compound or a salt or solvate thereof having a Formula I:
wherein:
R1 is hydrogen, an alkyl group, an alkylhydroxyl group, a carboxyl group, a 2,5-dioxopyrrolidinyl-1-yl-carboxylate group; an alkylamino group; an alkyl-N,N-dialkyl amino group; an alkyl-alkyoxy-amino group; an alkyl-alkyoxy-alkoxy-amino group; an alkyl-alkyoxy-alkoxy-carboxamide-alkyl-morpholine group; an alkyl-alkyoxy-alkoxy-carboxamide-alkyl-1-alkylpyrrolidine group; an alkyl-alkyoxy-alkoxy-carboxamide-alkyl-cyclohexyl group; and an alkyl-alkyoxy-alkoxy-carboxamide-alkyl-cyclobutyl group.

US Pat. No. 9,517,233

LOCAL COCHLEAR APPLICATION OF STATINS FOR STIMULATING NEURITE REGROWTH IN THE COCHLEA

Northwestern University, ...

1. A method of stimulating neurite growth from spiral ganglion neurons in an inner ear, comprising: contacting a neurite with
a statin, or a pharmaceutically acceptable salt thereof, wherein the statin comprises a compound selected from a group consisting
of compounds having formulas (II)-(VIII):

or a combination thereof.
US Pat. No. 9,468,923

POROUS POLYMER NETWORKS AND ION-EXCHANGE MEDIA AND METAL-POLYMER COMPOSITES MADE THEREFROM

Northwestern University, ...

1. A composite material comprising:
(a) a porous, three-dimensional, aromatic polymeric network comprising an organic polymer comprising phenolic groups, wherein
the phenolic groups are crosslinked through linkages comprising one or more non-phenolic aromatic rings; and

(b) metal nanoparticles distributed within the polymeric network.

US Pat. No. 9,455,127

LASER INDUCED PLASMA MICROMACHINING (LIPMM)

Northwestern University, ...

1. A system for laser-induced plasma micromachining of a work-piece comprising:
a dielectric fluid;
a dielectric fluid supply device to hold a work-piece in the dielectric fluid or to direct the dielectric fluid onto the work-piece;
a laser to emit a pulsed laser-beam;
a processor in electronic communication with the laser; and
a memory in electronic communication with the processor, wherein the memory comprises programming code for execution by the
processor, and the programming code is programmed to direct the laser to deliver the pulsed laser-beam into the dielectric
fluid to create a plasma generated at a focal point of the pulsed laser-beam in the dielectric fluid to micromachine, using
the plasma, the work-piece disposed adjacent to the focal point.

US Pat. No. 9,427,161

CURVED PASSIVE ACOUSTIC DRIVER FOR MAGNETIC RESONANCE ELASTOGRAPHY

Northwestern University, ...

1. A passive acoustic driver comprising:
a housing member comprising a housing member cavity;
a vibrating member disposed at least partially within the housing member cavity, wherein the vibrating member permanently
retains a curved shape while disposed within the housing member cavity; and

(1) a coil wrapped around the housing member; or (2) a cover member disposed over and attached to the housing member, the
vibrating member disposed between the housing member and the cover member, the cover member covering an end of the housing
member and an end of the vibrating member.

US Pat. No. 9,385,332

ORGANIC-INORGANIC HYBRID MULTILAYER GATE DIELECTRICS FOR THIN FILM TRANSISTORS

Northwestern University, ...

1. A method of fabricating a thin film transistor comprising an organic-inorganic hybrid multilayer dielectric material, a
gate electrode in contact with the organic-inorganic hybrid multilayer dielectric material, a thin film semiconductor, and
source and drain electrodes in contact with the thin film semiconductor, wherein the organic-inorganic hybrid multilayer dielectric
material comprises an inorganic primer layer and one or more bilayers deposited thereon, each bilayer comprising a ?-polarizable
layer and an inorganic oxide capping layer, wherein the inorganic oxide capping layer in each bilayer is coupled to the ?-polarizable
layer via bonds other than phosphonate bonds, the method comprising:
assembling the organic-inorganic hybrid multilayer dielectric material by performing one or more times the steps of (a) coupling
a ?-polarizable layer to either an existing inorganic primer layer or an existing inorganic oxide capping layer; and (b) coupling
a new inorganic oxide capping layer to the ?-polarizable layer via bonds other than phosphonate bonds;

depositing a thin film semiconductor either directly adjacent to the organic-inorganic hybrid multilayer dielectric material
or indirectly adjacent to the organic-inorganic hybrid multilayer dielectric material via an interlayer;

forming source and drain electrodes in contact with the thin film semiconductor; and
providing a gate electrode in contact with the organic-inorganic hybrid multilayer dielectric material.

US Pat. No. 9,340,576

METHODS OF TREATING DEPRESSION AND OTHER RELATED DISEASES

Northwestern University, ...

1. A method for treating dysthymic disorder in a patient in need thereof, comprising administering to said patient a 1 mg/kg
to about 10 mg/kg dose of a compound represented by:

or pharmaceutically acceptable salts, homologs, or hydrates thereof.
US Pat. No. 9,248,175

LIVE-ATTENUATED COMPOSITIONS FOR BACTERIAL INFECTIONS

NORTHWESTERN UNIVERSITY, ...

1. A solid or semi-solid composition formulated for therapeutic administration to a subject via a suppository comprising:
i) a sterilized carrier formulation selected from: an oily base, gelatin, and polyoxyethylene; and
ii) a live attenuated uropathogenic E. coli strain with a non-functional or deleted waal gene such that said live attenuated uropathogenic E. coli strain is lacking O-antigen ligase function.

US Pat. No. 9,198,948

METHODS OF TREATING DEPRESSION AND OTHER RELATED DISEASES

Northwestern University, ...

1. A method for treating bipolar disorder in a patient in need thereof, comprising administering to said patient about 1 mg/kg
to about 10 mg/kg of a compound represented by:
or a pharmaceutically acceptable salt thereof.
US Pat. No. 9,173,897

MOLECULAR TARGETS FOR ALS AND RELATED DISORDERS

NORTHWESTERN UNIVERSITY, ...

1. A method of detecting a mutation in a UBQLN2 nucleic acid in a human sample, comprising:
(a) contacting a UBQLN2 nucleic acid in a human sample with an oligonucleotide that specifically hybridizes to one or more
missense mutations in a UBQLN2 nucleic acid, wherein the one or more missense mutations results in a substitution of a proline
in the 12 P-X-X tandem repeats encoded by the UBQLN2 gene; and

(b) detecting hybridization of the oligonucleotide with the UBQLN2 nucleic acid under specific hybridization conditions, wherein
detection of hybridization is indicative of a mutation in the UBQLN2 nucleic acid.

US Pat. No. 9,169,294

ANTI-ANGIOGENIC MOLECULES, NANOSTRUCTURES AND USES THEREOF

NORTHWESTERN UNIVERSITY, ...

1. A composition, the composition comprising: (a) a hydrophobic tail; (b) a peptide sequence capable of beta-sheet formation;
(c) a flexible peptide linker; and (d) a peptide configured to inhibit angiogenesis.

US Pat. No. 9,140,771

IMAGING-BASED DIAGNOSTIC APPARATUS AND METHODS FOR QUANTIFYING CEREBRAL VASCULAR RESERVE

Northwestern University, ...

1. A magnetic resonance imaging (MRI) system, comprising:
an MRI scanner that has a first axis and a first plane perpendicular to said first axis, and that comprises a radio-frequency
(RF) antenna arrangement and a gradient coil arrangement;

a control computer configured to operate the MRI scanner in a first execution of a 3D pulse sequence to radiate an RF pulse
with said RF antenna arrangement to produce a first excitation of nuclear spins in an examination subject and to thereafter
acquire first raw data from the examination subject representing magnetic resonance signals produced by said first excitation
of said nuclear spins, and to generate magnetic gradient fields with said gradient coil arrangement that cause respective
samples of said first raw data to be entered into 3D k-space in N second planes that are each perpendicular to said first
plane and through which said first axis passes, with said N second planes thereby being radial planes in 3D k-space, with
N being an integer greater than 1, thereby producing a first set of 3D k-space data;

a stress-inducing unit configured to interact with the examination subject in the MRI scanner to induce a physiological stress
in the examination subject after acquiring said first 3D k-space data set;

said control computer being configured to operate the MRI scanner to execute a repetition of said 3D pulse sequence, including
radiating a second RF pulse, after inducing said physiological stress in the examination subject, to produce a second excitation
of nuclear spins in the examination subject, and to enter samples of second raw data, resulting from said second excitation,
into 3D k-space in said N second planes, thereby producing a second 3D k-space data set;

an image reconstruction computer provided with said first 3D k-space data set and said second 3D k-space data set, and configured
to reconstruct a first image of the examination subject from said first 3D k-space data set and to reconstruct a second image
of the examination subject from said second 3D k-space data set;

said image reconstruction computer being configured to bring said first image and said second image into registration with
each other and to identify at least one cerebral blood indicator, selected from the group consisting of cerebral blood flow
and cerebral blood volume, in said first image and said second image in registration with each other and to reconstruct a
cardiovascular reserve (CVR) image as a quotient having a numerator which is a difference of said at least one cerebral blood
indicator in said first image subtracted from said at least one cerebral blood indicator in said second image, and a denominator
which is said cerebral blood indicator in said first image multiplied by 100%; and

said image reconstruction computer being configured to make said CVR image available at an output of said image reconstruction
computer in electronic form, as a data file.

US Pat. No. 9,890,427

PARTICLES FOR DETECTING INTRACELLULAR TARGETS

NORTHWESTERN UNIVERSITY, ...

1. A method of determining the intracellular concentration of a target polypeptide or small molecule comprising the step of
contacting the target polypeptide or small molecule with a nanoparticle under conditions that allow association of the target
polypeptide or small molecule with the nanoparticle, said nanoparticle comprising a binding moiety aptamer specific for said
target polypeptide or small molecule, said binding moiety aptamer labeled with a marker, wherein the association of the target
polypeptide or small molecule and the nanoparticle results in detectable change in the marker, wherein the change in the marker
is proportional to the intracellular concentration of said target polypeptide or small molecule,
said binding moiety aptamer is a single-stranded polynucleotide covalently attached to said nanoparticle and said marker is
a fluorescent label attached to a polynucleotide hybridized to said binding moiety aptamer, wherein said polynucleotide hybridized
to said binding moiety aptamer is not attached to a nanoparticle and wherein association of said binding moiety aptamer with
said target polypeptide or small molecule releases said hybridized polynucleotide and said marker is detectable after release.

US Pat. No. 9,615,918

MEDICAL DEVICES, SYSTEMS, AND KITS FOR THE MEDIALIZATION OF A VOCAL CORD

COOK MEDICAL TECHNOLOGIES...

1. A method of medializing a vocal cord within the larynx of a patient, comprising:
making an incision over the thyroid cartilage of said patient;
dissecting soft tissue underlying the incision to expose the lateral aspect of the thyroid cartilage of said patient;
drilling a hole in the thyroid cartilage of said patient at a point half way between the anterior and posterior aspects of
the thyroid cartilage;

placing a light source through the hole;
viewing light emitted from the light source; and
advancing a medical device through the hole to move said vocal cord toward a midline of said larynx to achieve an artificial
placement of said vocal cord;

wherein the advancing a medical device through the hole is performed while said patient is phonating.

US Pat. No. 9,612,299

GROUP III-V FERROMAGNETIC/NON-MAGNETIC SEMICONDUCTOR HETEROJUNCTIONS AND MAGNETODIODES AND RELATED METHODS OF MONITORING MAGNETORESISTANCE

Northwestern University, ...

1. A method of monitoring magnetoresistance, said method comprising;
providing a junction device comprising a heterojunction composite comprising a p-type Group III-V ferromagnetic semiconductor
component comprising a compound of a formula

(MIII1-xMTMx)MV and an n-type Group III-V non-magnetic semiconductor component comprising a compound of a formula (MIIIMV), wherein MIII comprises a Group III metal component, MTM comprises a magnetic transition metal component and MV comprises a Group V metal component, and x is less than about 0.2; a diode coupled to said ferromagnetic semiconductor component
and said non-magnetic semiconductor component of said heterojunction composite; and a voltage source for application of voltage
across said device;
applying a voltage across said device;
applying a magnetic field oriented with respect to a current flow through said diode of said device, said magnetic field applied
from about parallel to about perpendicular to direction of said current flow; and

measuring magnetoresistance of said current responsive to said applied magnetic field.

US Pat. No. 9,610,560

METAL-ORGANIC FRAMEWORK COMPOUNDS WITH LIGAND-FUNCTIONALIZED METAL NODES

Northwestern University, ...

20. A ligand-coordinated metal-organic framework compound comprising a plurality of metal nodes coordinated by organic molecular
linkers, wherein at least some of the metal nodes are coordinated to carboxylate ligands via carboxylate oxygen atoms.

US Pat. No. 9,562,226

DEVICE FOR ISOLATING AN ANALYTE FROM A SAMPLE, AND METHODS OF USE

Quidel Corporation, San ...

1. A device, comprising:
a rigid body having a first face and a second face, and defining within said first face:
a first cavity having an outlet, a second cavity, and a third cavity,
a first flow path positioned between and connecting the outlet of the first cavity and the second cavity,
said outlet comprising a constricted region between said first cavity and said first flow path, wherein the outlet constricted
region is more narrow than the first flow path, and

a second flow path positioned between and connecting the second cavity and the third cavity, the second flow path comprising
an upper and a lower surface and a barrier region having a top surface which is above the level of the lower surface of the
second flow path;

wherein the first flow path is contiguous with the second flow path;
a wall member secured to at least a portion of the first face of the rigid body, said wall member disposed over the first
cavity, the second cavity, and the third cavity, thereby defining a first chamber, a second chamber, and a third chamber,
the third chamber having a width and a length, wherein the length is greater than the width; and

one or more inlet ports in direct communication with at least the first chamber and the third chamber for introduction of
one or more water-miscible liquid reagents into each of the first and third chambers.

US Pat. No. 9,562,005

METALLATED METAL-ORGANIC FRAMEWORKS

Northwestern University, ...

1. A method of metallating a porous metal-organic framework comprising inorganic nodes and organic linkers, the method comprising
depositing a film comprising a metal on the surfaces within the pores of the metal-organic framework via atomic layer deposition.
US Pat. No. 9,556,232

ANTI-ANGIOGENIC MOLECULES, NANOSTRUCTURES AND USES THEREOF

Northwestern University, ...

1. A composition comprising peptide amphiphile molecules comprising: (a) a hydrophobic tail comprising a C6-C22 alkyl group;
(b) a peptide comprising VA and capable of beta sheet formation; (c) a peptide configured to inhibit angiogenesis; and (d)
a flexible peptide linker between the peptide comprising VA and the peptide configured to inhibit angiogenesis; wherein the
peptide amphiphile molecules self-assemble in aqueous solution into nanofibers comprising a hydrophobic core, stabilized by
beta-sheet formation down a long axis of the nanofiber, and displaying the peptide configured to inhibit angiogenesis on the
nanofiber surface.
US Pat. No. 9,506,056

NUCLEIC ACID FUNCTIONALIZED NANOPARTICLES FOR THERAPEUTIC APPLICATIONS

NORTHWESTERN UNIVERSITY, ...

1. A method of increasing cellular uptake of a first plurality of nanoparticles relative to a second plurality of nanoparticles,
the method comprising:
producing the first plurality of nanoparticles comprising a first mixed monolayer on the surface of the nanoparticles, the
first mixed monolayer comprising a first oligonucleotide and a first diluent, wherein the first plurality consists essentially
of nanoparticles having oligonucleotide functionalized on the nanoparticle at surface density X which is at least about 1.5
picomoles/cm2 (pmol/cm2) to about 25 pmol/cm2;

producing the second plurality of nanoparticles comprising a second mixed monolayer on the surface of the nanoparticles, the
second mixed monolayer comprising a second oligonucleotide and a second diluent, wherein the second plurality consists essentially
of nanoparticles having oligonucleotide functionalized on the nanoparticle at surface density Y which is at least about 0.3
pmol/cm2 to about 20 pmol/cm2;

wherein X is greater than Y;
contacting a first cell with the first plurality and contacting a second cell with the second plurality;
wherein uptake of the first plurality of nanoparticles by the first cell is increased relative to uptake of an equal concentration
of the second plurality by a second cell, wherein the first cell and the second cell are of the same type, wherein the first
oligonucleotide and the second oligonucleotide do not comprise a cell-specific recognition element, and wherein the nanoparticles
in the first plurality of nanoparticles and the nanoparticles in the second plurality of nanoparticles have a mean diameter
of from about 5 to about 50 nanometers.

US Pat. No. 9,221,091

SYSTEM AND METHOD FOR INCREMENTAL FORMING

Northwestern University, ...

1. A system comprising:
a modular frame assembly configured to hold a work piece comprising top and bottom axis sections and top and bottom blankholder
sections;

first and second tool positioning assemblies, one of said positioning assemblies coupled with each of the top and bottom axis
sections of the frame assembly, the first and second tool positioning assemblies configured to be opposed to each other on
opposite sides of a work piece supported between the top and bottom blankholder sections, each tool positioning assembly comprising:

a tool holder configured to secure a tool to the tool positioning assembly;
a first axis assembly configured to articulate the tool holder along a first axis, the first axis assembly comprising first
and second guides, the first and second guides of the first axis assembly extending generally parallel to the first axis and
disposed on opposing sides of the tool holder with respect to the first axis, the first axis assembly comprising first and
second carriages articulable along the first and second guides of the first axis assembly, respectively, in the direction
of the first axis;

a second axis assembly configured to articulate the tool holder along a second axis that is substantially perpendicular to
the first axis, the second axis assembly comprising first and second guides, the first and second guides of the second axis
assembly extending generally parallel to the second axis and disposed on opposing sides of the tool holder with respect to
the second axis, the second axis assembly comprising first and second carriages articulable along the first and second guides
of the second axis assembly, respectively, in the direction of the second axis; and

a third axis assembly configured to articulate the tool holder along a third axis that is substantially perpendicular to the
first axis and substantially perpendicular to the second axis, the third axis assembly comprising first and second guides,
the first and second guides of the third axis assembly extending generally parallel to the third axis and disposed on opposing
sides of the tool holder with respect to the third axis, the third axis assembly comprising first and second carriages articulable
along the first and second guides of the third axis assembly, respectively, in the direction of the third axis;

a first drive assembly operably coupled to at least one of the first and second guides of the first axis assembly, the first
drive assembly configured to articulate the first and second carriages of the first axis assembly along the first and second
guides of the first axis assembly;

a second drive assembly operably coupled to at least one of the first and second guides of the second axis assembly, the second
drive assembly configured to articulate the first and second carriages of the second axis assembly along the first and second
guides of the second axis assembly;

a third drive assembly operably coupled to at least one of the first and second guides of the third axis assembly, the third
drive assembly configured to articulate the first and second carriages of the third axis assembly along the first and second
guides of the third axis assembly;

each of the drive assemblies comprising a linear drive assembly having a motor in threaded engagement therewith so that upon
rotation of the motor the associated carriage is moved linearly; and

a current source configured to deliver a current passing between the tool holder of the first tool positioning assembly and
the tool holder of the second tool positioning assembly, wherein the current passes through the work piece when a first tool
secured to the first tool holder and a second tool secured to the second tool holder engage the work piece and wherein each
of the first and second tool positioning assemblies comprises a tool holder frame movably coupled to the first and second
guides of one of the first axis assembly, second axis assembly, or third axis assembly, the tool holder frame configured to
translate substantially along the first and second guides; and

an insulating member interposed between the tool holder frame and the tool holder, the insulating member configured to insulate
the tool holder frame from the current passing between the tool holder of the first tool positioning assembly and the tool
holder of the second tool positioning assembly.

US Pat. No. 9,216,155

SYNTHETIC NANOSTRUCTURES INCLUDING NUCLEIC ACIDS AND/OR OTHER ENTITIES

Northwestern University, ...

1. A method for inhibiting gene expression comprising:
delivering a structure to a subject or a biological sample in an effective amount for inhibiting gene expression in the subject
or biological sample, the structure comprising a nanostructure core; a shell comprising a lipid surrounding and attached to
the nanostructure core or a hydrophobic shell surrounding the nanostructure core; and an oligonucleotide adapted to regulate
gene expression associated with at least a portion of the shell, wherein the structure is adapted to sequester cholesterol,
wherein the oligonucleotide inhibits gene expression of a target by at least about 50%, at least about 60%, at least about
70%, at least about 80%, or at least about 90% under physiological conditions and at a concentration where a nonsense or sense
control has little or no effect, wherein the oligonucleotide is a cholesterol-oligonucleotide adsorbed to a surface of the
shell.

US Pat. No. 9,162,968

CYCLOHEXANE-1,3-DIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Northwestern University, ...

1. A compound of a formula:
or a pharmaceutically acceptable salt thereof, wherein:
each R is independently hydrogen, halogen, optionally substituted C1-6 aliphatic, optionally substituted phenyl, optionally substituted benzyl, or two R on the same carbon are taken together to
form a 5-6 membered saturated, partially saturated, or aryl ring having 1-3 heteroatoms independently selected from nitrogen,
oxygen, and sulfur;

R1, R2, and R3 are each independently —R, —OR, —SR, —S(O)R, —SO2R, —OSO2R, N(R)2, —NRC(O)R, —NRC(O)(CO)R, —NRC(O)N(R)2, —NRC(O)OR, —N(R)S(O)R, —N(R)SO2R, —N(R)SO2OR, —C(O)R, —C(O)OR, —OC(O)R, —OC(O)OR, —C(O)N(R)2, —OC(O)N(R)2, or an optionally substituted 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring having 0-4 heteroatoms
independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered saturated, partially unsaturated,
or aryl bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;

L is a valence bond or a bivalent saturated or partially unsaturated, branched or unbranched C1-10 hydrocarbon chain, wherein 1-3 methylene units of L are optionally and independently replaced by —NR—, —N(R)C(O)—, —C(O)N(R)—,
—N(R)SO2—, —SO2N(R)—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —S—, —S(O)— or —SO2—, and wherein L is optionally substituted with 1-4 R groups, wherein two R on the same carbon or on adjacent carbons are
optionally taken together to form a 3-6 membered saturated spirocyclic or fused monocyclic ring containing 0-2 heteroatoms
independently selected from nitrogen, oxygen, and sulfur;

Ring A is a 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring optionally containing 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur;

m is 0-5;
each Ra is independently —R, —OR, —SR, —S(O)R, —SO2R, —OSO2R, N(R)2, —NRC(O)R, —NRC(O)(CO)R, —NRC(O)N(R)2, —NRC(O)OR, —N(R)S(O)R, —N(R)SO2R, —N(R)SO2OR, —C(O)R, —C(O)OR, —OC(O)R, —OC(O)OR, —C(O)N(R)2, —OC(O)N(R)2, or:

two Ra on adjacent carbons are taken together to form an optionally substituted 3-12 membered saturated, partially unsaturated, or
aryl fused ring containing 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or: at least one Ra is independently


 wherein Q is a valence bond or a bivalent optionally substituted saturated or partially unsaturated, branched or unbranched
C1-10 hydrocarbon chain, wherein 1-3 methylene units of Q are optionally and independently replaced by —NR—, —N(R)C(O)—, —C(O)N(R)—,
—N(R)SO2—, —SO2N(R)—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —S—, —S(O)— or —SO2—;

Ring B is a 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring optionally containing 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur;

n is 0-5;
each Rb is independently —R, —OR, —SR, —S(O)R, —SO2R, —OSO2R, N(R)2, —NRC(O)R, —NRC(O)C(O)R, —N(R)C(O)N(R)2, —N(R)C(O)OR, —N(R)S(O)R, —N(R)SO2R, —N(R)SO2OR, —C(O)R, —C(O)OR, —OC(O)R, —OC(O)OR, —C(O)N(R)2, —OC(O)N(R)2; and

R4 and R4? are each independently R, or R4 and R4? are taken together to form an alkenylene optionally substituted with one or two Re groups; wherein

each Rc is independently —R, —OR, —CN, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, —N(R)2, or wherein Re is a 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring optionally containing 0-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur, or an 8-10 membered saturated, partially unsaturated, or aryl bicyclic ring optionally
containing 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein Rc is optionally substituted with p occurrences of Rd, wherein:

p is 0 to 5; and
each Rd is independently —R, —OR, —CN, —C(R)3, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2, providing where R1, R2, R3 and R4 are hydrogen, L is a valence bond and Ring A is phenyl and wherein Ra is halogen, m is 2-5 and two Ras are meta to said valence bond, and wherein Ra is optionally substituted C1-6 aliphatic, at least one Ra is meta to said valance bond.

US Pat. No. 9,616,113

PEPTIDE CONJUGATED PARTICLES

NORTHWESTERN UNIVERSITY, ...

1. A composition comprising surface functionalized biodegradable PLG particles comprising encapsulated gliaden or one or more
antigenic epitopes thereof wherein said PLG particles have a copolymer ratio of about 50:50 poly(lactide-co-glycolide), a
diameter of about 400 nm to about 800 nm and a zeta potential of about ?75 mV to about ?50 mV.
US Pat. No. 9,528,137

METHODS FOR CELL-FREE PROTEIN SYNTHESIS

Northwestern University, ...

1. A cell-free protein synthesis platform for preparing protein from a transcription template, the cell-free protein synthesis
platform comprising a reaction mixture formed by combining:
(a) a Saccharomyces cerevisiae cellular extract prepared from mid-exponential to late-exponential cultures in the range from about 6 OD600 to about 18 OD600;

(b) a reaction buffer;
(c) a phage RNA polymerase; and
(d) the transcription template,
wherein the transcription template comprises: (i) at least one DNA encoding an open reading frame, (ii) a 5?-UTR comprising
an internal ribosome entry site (IRES) or a cap-independent translation enhancer, and (iii) a 3?-UTR comprising a poly(A)
3?-terminus, and wherein the transcription template is operably linked to a promoter specific for the phage RNA polymerase;
the phage RNA polymerase is capable of transcribing the transcription template to form a translation template; and the reaction
mixture formed by combining (a), (b), (c), and (d) can sustain cell-free protein synthesis through a combined transcription/translation
reaction.

US Pat. No. 9,499,494

PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

Northwestern University, ...

1. A compound of Formula I:

or a pharmaceutically acceptable salt thereof, wherein:
L1 is (C(R)2)n— and wherein n is 2 to 5;

R1 is phenyl, wherein R1 is optionally substituted with p occurrences of Ra, wherein p is 0 to 2, inclusive;

each Ra is independently selected from the group consisting of —R, —OR, —CN, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, and —N(R)2, or wherein Ra is an optionally substituted 5-6 membered monocyclic saturated, partially saturated, or aromatic ring having 1-4 heteroatoms
independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered saturated, partially saturated,
or aromatic bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;

each R is independently hydrogen, halogen, optionally substituted C1-6 aliphatic, optionally substituted phenyl, optionally substituted benzyl, or two R on the same nitrogen are taken together
to form a 5-6 membered saturated, partially saturated, or aromatic ring having 1-3 heteroatoms independently selected from
nitrogen, oxygen, and sulfur;

except for L1 and L2, where each R is independently hydrogen, halogen, optionally substituted phenyl, optionally substituted benzyl, or two R
on the same nitrogen are taken together to form a 5-6 membered saturated, partially saturated, or aromatic ring having 1-3
heteroatoms independently selected from nitrogen, oxygen, and sulfur, and except for Rd where Rc is phenyl and each R is independently hydrogen, optionally substituted phenyl, optionally substituted benzyl, or two R on
the same nitrogen are taken together to form a 5-6 membered saturated, partially saturated, or aromatic ring having 1-3 heteroatoms
independently selected from nitrogen, oxygen, and sulfur

L2 is —(C(R)2)m— and wherein m is 2 to 5;

R2 is phenyl wherein R2 is optionally substituted with q occurrences of Rb, wherein q is 0 to 2;

each Rb is independently selected from the group consisting of —R, —OR, —CN, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, and —N(R)2, or wherein Rb is an optionally substituted 5-6 membered monocyclic saturated, partially saturated, or aromatic ring having 1-4 heteroatoms
independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered saturated, partially saturated,
or aromatic bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;

R3 and R3? are independently hydrogen or halogen, or R3 and R3? are taken together to form a C1 alkenylene optionally substituted with one or two Rc groups;

each Rc is independently —R, —OR, —CN, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, or —NRSO2R, or wherein Rc is phenyl, a 5-6 membered monocyclic saturated, partially saturated, or aromatic ring having 1-4 heteroatoms independently
selected from nitrogen, oxygen, or sulfur, or an 8-10 membered saturated, partially saturated, or aromatic bicyclic ring having
0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein Rc is optionally substituted with t occurrences of Rd, wherein t is 0 to 5, inclusive; and

each Rd is independently —R, —OR, —CN, —C(R)3, —NO2, —SR, —S(O)R, —SO2R, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2; providing said compound is not


US Pat. No. 9,499,574

ARSENOPLATIN ANTI-CANCER AGENTS

Northwestern University, ...

1. A compound having the structure of formula (I)

wherein M is Pt, Pd or Ni; Q is As, Sb or Bi; Z1 is N; Z2 is O or S; L1 and L2 are independently C(O), C—R1 or C—R2; X is a Lewis base; Y1 and Y2 are independently selected from —OR3, —SR3 and —SR4, wherein R1 and R2 are independently selected from hydrogen, halogen, cyano, keto, ester, ether, thiol, thioether, thioester, imino, C1-C10 alkyl, C1-C10 alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C3-C15 cycloalkyl, heteroaryl, and C3-C15 heterocycloalkyl;

wherein R3 and R4 are independently selected from hydrogen, C1-C10 alkyl, C1-C10 alkenyl, alkynyl, alkoxyl, amino, amidyl, immino, sulfonyl, sulfoxyl, phosphoryl, phosphoryl ester, glycosyl, aryl, C3-C15 cycloalkyl, heteroaryl, and C3-C15 heterocycloalkyl;

wherein the Lewis base can be halogen, N-bonded cyano, nitroso, nitroxyl, N-bonded C1-C10 alkyl, alkenyl, N-bonded C3-C10 cycloalkyl, N-bonded heteroalkyl, N-bonded C1-C10 heteroalkenyl, N-bonded aryl, N-bonded heteroaryl, N-bonded C3-C15 heterocycloalkyl, —NR5R6, N-bonded ligand, S-bonded cyano, sulfonyl, sulfoxyl, thiol, S-bonded thioether, S-bonded thioester, S-bonded C1-C10 alkyl, C1-C10 alkenyl, S-bonded C3-C10 cycloalkyl, S-bonded C1-C10 heteroalkyl, S-bonded C1-C10 heteroalkenyl, S-bonded aryl, S-bonded heteroaryl, S-bonded C3-C15 heterocycloalkyl, —SR5, S-bonded ligand, O-bonded C3-C10 cycloalkyl, O-bonded C1-C10 heteroalkyl, O-bonded C1-C10 heteroalkenyl, O-bonded aryl, O-bonded heteroaryl, O-bonded C3-C15 heterocycloalkyl, —OR5, O-bonded carboxylato, O-bonded polycarboxylato, O-bonded ligand, or P-bonded phosphine having formula P(R7)3-x(R8)x, where x is 0, 1, 2 or 3;

wherein R5 and R6 are independently selected from hydrogen, O, —CO2R9, —COR9, C1-C10 alkyl, C1-C10 alkenyl, aryl, heteroaryl, C3-C15 cycloalkyl and C3-C15 heterocycloalkyl;

wherein R7 and R8 are independently selected from C1-C10 alkyl, C1-C10 alkenyl, aryl, heteroaryl, C3-C15 cycloalkyl and C3-C15 heterocycloalkyl; and

wherein R9 is selected from hydrogen, hydroxyl, halogen, amine, thiol, ether, C1-C10alkyl, C1-C10 alkenyl, aryl, heteroaryl, C3-C15 cycloalkyl and C3-C15 heterocycloalkyl.

US Pat. No. 9,168,580

SYSTEM AND METHOD FOR ACCUMULATIVE DOUBLE SIDED INCREMENTAL FORMING

Northwestern University, ...

1. A system comprising:
a first tool configured to be disposed on a first side of a deformable sheet;
a second tool configured to be disposed on an opposite, second side of the sheet;
one or more moving assemblies configured to move the first tool and the second tool relative to the sheet;
a control unit configured to control movement of the first tool and the second tool by the one or more moving assemblies,
wherein the control unit is configured to move at least one of the first tool or the second tool in a first deformation direction
to deform the sheet, then move the first and second tools laterally relative to the sheet to a subsequent location while engaging
the sheet, then move at least one of the first tool or the second tool in the first deformation direction or an opposite second
deformation direction to deform the sheet, and to continue moving the first and second tools to deform the sheet in order
to create a three-dimensional component from the sheet;

an input module configured to obtain a three-dimensional model of a component to be formed from a deformable sheet by first
and second tools that engage corresponding first and second opposite sides of the sheet and that move relative to the sheet
to deform the sheet, the three-dimensional model including plural three-dimensional features that protrude from at least one
of the first side or second side of the sheet;

an equalization module configured to an incremental depth at which the at least one of the first and second tools move toward
or away from the sheet to form the features in the sheet, the incremental depth based on a number of curves formed by intersections
of the model with a set of planes oriented parallel to the sheet;

a sorting module configured to associate at least a first set of the curves formed by the intersections of the model with
the planes with a first feature of the features in the model and a second set of the curves formed by the intersections of
the model with the planes with a different, second feature of the features in the model;

a point generation module configured to determine one or more toolpaths that the first and second tools follow in order to
deform the sheet into the component, the point generation module configured to determine segments of the model that are disposed
between neighboring planes in the set of planes and to determine one or more helical curves extending along the segments from
an internal area of the sheet toward outer boundaries of the sheet; and

a path writing module configured to identify contact points along the one or more toolpaths and directions in which the first
and second tools are to move along the one or more toolpaths, the contact points being locations where the first and second
tools are to engage and deform the sheet to form the component from the sheet based on the model, wherein the path writing
module determines the contact points and the directions such that the first and second tools move along the one or more toolpaths
in an in-to-out direction laterally along the sheet.

US Pat. No. 9,139,827

POLYVALENT RNA-NANOPARTICLE COMPOSITIONS

NORTHWESTERN UNIVERSITY, ...

1. A nanoparticle composition comprising a duplex, the duplex comprising:
(a) a ribonucleic acid (RNA) polynucleotide functionalized to the nanoparticle and comprising a sequence that is identical
to a target polynucleotide; and

(b) an additional polynucleotide having a sequence that forms the duplex with the RNA polynucleotide under conditions appropriate
to form the duplex, the duplex providing a polypeptide interaction site;

the additional polynucleotide having at least one domain sufficiently complementary to a sequence in the target polynucleotide
to permit hybridization of the additional polynucleotide to the target polynucleotide under appropriate conditions; wherein

the duplex is located distal and not proximal to the nanoparticle, and the distance of the duplex from the nanoparticle is
equivalent to at least 10 nucleotides.

US Pat. No. 9,131,321

HEARING ASSISTANCE DEVICE CONTROL

Northwestern University, ...

1. A method comprising:
identifying a set of audiological values for each of a plurality of individuals in a population of hearing assistance device
users, wherein each of the sets comprises values corresponding to a first number of parameters associated with settings of
a corresponding hearing assistance device;

converting, using a processor, the set of audiological values for each of the plurality of individuals to a corresponding
reduced data set, wherein each of the reduced data sets comprises values corresponding to a second number of parameters, and
is represented as a point in a space that has a number of dimensions equal to the second number, the second number being less
than the first number;

calculating, using the processor, a trajectory representative of a distribution of the reduced data sets in the space, wherein
different points along the trajectory represent corresponding settings for hearing assistance devices; and

storing a representation of the trajectory on a storage device such that data corresponding to positions along the trajectory
is available for providing to hearing assistance devices.

US Pat. No. 9,085,460

NANOPOROUS CARBOHYDRATE FRAMEWORKS AND THE SEQUESTRATION AND DETECTION OF MOLECULES USING THE SAME

Northwestern University, ...

1. A ?-cyclodextrin-based metal-organic framework comprising a plurality of metal cations and a plurality of ?-cyclodextrin
molecules or a plurality of ?-cyclodextrin derivative molecules coordinated to the plurality of metal cations, the ?-cyclodextrin-based
metal-organic framework being porous,
wherein the ?-cyclodextrin or ?-cyclodextrin derivative is a compound of the Formula I:

wherein
n=2; and
R is selected from the group consisting of —OH; —NR?R?; —S(?O)2R?; —S(?O)OR?; —S(?O)R?; —C(?O)OR?; —CN; —C(?O)R?; —SR?, —N?N+?N?; —NO2, —OSO2R?; —C(?O)OR?, —O(?S)SR?, —P(?O)(OR?)2; —OP(?O)(OR?)2; —P(?O)(OR?)R?; —N?R?R?; —NR?P(OR?)(OR??); —OC(?O)NR?R?; C1-C18 alkyl optionally substituted with one, two, three, four or five R1 groups; C2-C18 alkenyl optionally substituted with one, two, three, four or five R1 groups; C2-C18 alkynyl optionally substituted with one, two, three, four or five R1 groups; C1-C18 alkoxy optionally substituted with one, two, three, four or five R1 groups; aryl optionally substituted with one, two, three, four or five R2 groups; heteroaryl optionally substituted with one, two, three, four or five groups independently selected from R2 groups; and cycloalkyl optionally substituted with one, two, three, four or five groups independently selected from R2 groups; wherein

each R1 group is independently selected from hydroxyl, halo, lower alkoxy, —NR?R?, —S(?O)2R?, —S(?O)OR?, —S(?O)R?, —C(?O)OR?, —CN, —C(?O)R?, —N?N+?N?, —SR?, —NO2, —OSO2R?, —C(?O)OR?, —O(?S)SR?, —P(?O)(OR?)2, —OP(?O)(OR?)2; —P(?O)(OR?)R?, —N?R?R?, —NR?P(OR?)(OR??), —OC(?O)NR?R?, aryl optionally substituted with one, two, three, four or five R?
groups; heteroaryl optionally substituted with one, two, three, four or five groups independently selected from R? groups;
and cycloalkyl optionally substituted with one, two, three, four or five groups independently selected from R? groups;

each R2 group is independently selected from lower alkyl, lower alkyenyl, lower alkynyl, hydroxyl, halo, lower alkoxy, —NR?R?, —S(?O)2R?, —S(?O)OR?, —S(?O)R?, —C(?O)OR?, —CN, —C(?O)R?, —N?N+?N?, —SR?, —NO2, —OSO2R?, —C(?O)OR?, —O(?S)SR?, —P(?O)(OR?)2, —OP(?O)(OR?)2; —P(?O)(OR?)R?; —N?R?R?; —NR?P(OR?)(OR??); —OC(?O)NR?R?, aryl optionally substituted with one, two, three, four or five R?
groups; heteroaryl optionally substituted with one, two, three, four or five groups independently selected from R? groups;
and cycloalkyl optionally substituted with one, two, three, four or five groups independently selected from R? groups; and

each R? and R? are independently selected from the group consisting of H, lower alkyl and aryl,
wherein the ?-cyclodextrin-based metal organic framework has a crystal structure with a I432 space group.
US Pat. No. 9,044,454

REGULATION OF MICROVASCULATURE OCCLUSION

NORTHWESTERN UNIVERSITY, ...

1. A method of occluding blood flow to a tumor of a subject comprising:
(a) administering a first composition comprising synthetic microspheres to microvasculature within said tumor; and
(b) administering a second composition comprising a MMP 2/9 inhibitor to said tumor;wherein steps (a) and (b) result in a least partial occlusion of blood flow to said tumor in said subject.