US Pat. No. 9,402,835

ANIMAL TREATMENTS

NEWMARKET PHARMACEUTICALS...

1. A method of treating gastric ulcers in an animal in need of said treatment comprising: determining a dose of omeprazole
required; administering orally to a pre-gastric mucosa cell of said animal in need of said treatment, a gelatin-based Direct
Systemic Introduction (DSI) composition comprising omeprazole; wherein the DSI composition in the animal's oral cavity is
dissolved in 30 seconds or less; wherein greater than 50% of the administered omeprazole is absorbed into the animal's circulatory
system through the pre-gastric mucosal cells lining the animal's alimentary canal; and wherein the pH of the composition is
between 6 and 10.
US Pat. No. 10,918,631

PHARMACEUTICAL COMPOSITIONS FOR DIRECT SYSTEMIC INTRODUCTION

NewMarket Pharmaceuticals...

1. A method of making a pharmaceutical composition for direct system introduction, the composition comprising:about 10-17 dry mass % bovine gelatin,
about 10-17 dry mass % mannitol,
about 0-1 dry mass % of a surfactant,
about 0-0.5 dry mass % of a flavorant, and
about 65-80 dry mass % of an active pharmaceutical ingredient which is a proton pump inhibitor;wherein the method comprises:combining the active pharmaceutical ingredient with one or more pharmacologically inactive compound(s) to form a pre-formulation;
freezing the pre-formulation;
reducing the pressure surrounding the pre-formulation; and
lyophilizing the pre-formulation.
US Pat. No. 10,702,509

ANIMAL TREATMENTS

NewMarket Pharmaceuticals...

1. A method of treating parasites, summer sores, or dermatitis in an animal of need thereof, the method comprising:determining a dose of ivermectin required; and
administering orally to a pre-gastric mucosal cell of the animal a Direct Systemic Introduction (DSI) composition comprising ivermectin,
wherein the DSI composition in the animal's oral cavity is dissolved in less than about 75 seconds, and
wherein measuring of greater than 50% of the administered ivermectin is absorbed into the animal's circulatory system via the pre-gastric mucosal cells lining the animal's alimentary canal prior to the animal's secretory stomach.
US Pat. No. 10,695,332

PHARMACEUTICAL COMPOSITIONS FOR DIRECT SYSTEMIC INTRODUCTION

NewMarket Pharmaceuticals...

1. A method of treating gastric ulcers, duodenal ulcers, Zollinger-Ellison syndrome, laryngopharyngeal reflux, dyspepsia, peptic ulcer disease, gastritis, or gastroesophageal reflux in an animal needing treatment, comprising administering an effective amount of a pharmaceutical composition for direct systemic introduction (DSI) to the animal, wherein the pharmaceutical composition for DSI comprises: about 10-17 dry mass % bovine gelatin, about 10-17 dry mass % mannitol, about 0-1 dry mass % of a surfactant, about 0-0.5 dry mass % of a flavorant, and about 65-80 dry mass % of omeprazole.