US Pat. No. 9,226,943

LACTOBACILLUS JOHNSONII CNCM I-1225 FOR THE ANTI-ADHESION OF SKIN PATHOGENIC FLORA

Nestec S.A., Vevey (CH)

1. A method for the treatment of skin disorders caused by Staphylococcus aureus comprising: topically administering to a subject in need of such treatment a composition comprising deactivated Lactobacillus johnsonii CNCM I-1225 in an amount corresponding to 10×108 to 10×1012 cfu/g of the composition by dry weight, wherein the Lactobacillus johnsonii CNCM I-1225 was deactivated by lyophilization of a suspension subjected to cycles of freezing in liquid nitrogen and thawing,
whereby skin disorders caused by Staphylococcus aureus are treated.

US Pat. No. 9,268,984

SUPPORT AND CAPSULE FOR PREPARING A BEVERAGE BY CENTRIFUGATION, SYSTEM AND METHOD FOR PREPARING A BEVERAGE BY CENTRIFUGATION

Nestec S.A., Vevey (CH)

1. A code support adapted to be associated with or part of a capsule intended for delivering a beverage in a beverage producing
device by centrifugation of the capsule, the support comprising a code formed by at least a first sequence of symbols and
a second sequence of symbols, the code being represented on the support so that each symbol is sequentially readable by a
reading arrangement of an external reading device while the capsule is rotated along an axis of rotation:
the first sequence comprising at least one first preamble sequence of symbols and at least one first data sequence of symbols;
the second sequence comprising at least one second preamble sequence of symbols and at least one second data sequence of symbols;
and

the first preamble sequence being distinct from the second preamble sequence.
US Pat. No. 9,301,539

VEGETABLE-BASED MINCED MEAT ALTERNATIVE

Nestec S.A., Vevey (CH)

1. A plant protein-based food product comprising at least 50 wt. % protein, wherein the protein is gluten or is proteinaceous
material derived from gluten and has been fermented by a mold selected from the group consisting of Rhizopus, Mucor, Neurospora and Amylomyxes, and the product has the texture of minced meat.

US Pat. No. 9,049,883

NUTRITIONAL COMPOSITIONS HAVING REDUCED SODIUM CONTENT AND METHODS FOR MAKING SAME

Nestec S.A., Vevey (CH)

1. A method for producing a low sodium nutritional composition formulated for a young child up to about four years of age,
wherein the nutritional composition has less than or equal to about 200 mg sodium per 100 g of nutritional composition, the
method comprising the steps of:
preparing a first slurry, wherein the first slurry comprises water and one or more dry ingredients, wherein the dry ingredients
include at least one food component selected from the group consisting of meat, beans, milk, cheese, yogurt, grains, pasta,
fruit, vegetables, and combinations thereof;

heating the first slurry to a first predetermined temperature in a range of from about 170° F. to about 200° F.;
cooling the first slurry to a second predetermined temperature in a range of from about 50° F. to 100° F.;
adding a second slurry to the first slurry to form a nutritional composition, wherein the second slurry comprises at least
cold water and a source of potassium chloride, wherein the source of potassium chloride is present in the second slurry in
an amount greater than or equal to about 22 g per 100 g of slurry, wherein the second slurry has a temperature of less than
or equal to about 32° F. at the time that it is added to the first slurry, and wherein the source of potassium chloride is
present in an amount from about 0.1% to about 1.0% by weight of the nutritional composition; and

packaging the nutritional composition.
US Pat. No. 9,320,767

EXTRUDED NON-REPLICATING PROBIOTIC MICRO-ORGANISMS AND THEIR HEALTH BENEFITS

Nestec S.A., Vevey (CH)

1. A method for the treatment of disorders related to a compromised immune defense, the method comprising administering to
an individual in need of same a composition comprising non-replicating probiotic micro-organisms selected from the group consisting
of Bifidobacterium longum NCC 3001, Bifidobacterium longum NCC 2705, Bifidobacterium breve NCC 2950, Bifidobacterium lactis NCC 2818, Lactobacillus johnsonii NCC533, Lactobacillus paracasei NCC 2461, Lactobacillus rhamnosus NCC 4007, Lactobacillus reuteri DSM17938, Lactobacillus reuteri ATCC55730, Streptococcus thermophilus NCC 2019, Streptococcus thermophilus NCC 2059, Lactobacillus casei NCC 4006, Lactobacillus acidophilus NCC 3009, Lactobacillus casei ACA-DC 6002 (NCC 1825), Escherichia coli Nissle, Lactobacillus bulgaricus NCC 15, Lactococcus lactis NCC 2287, and combinations thereof, wherein the probiotic micro-organisms are rendered non-replicating by direct expansion
extrusion cooking at a temperature between 110 and 180° C. and at a moisture content below 20 wt %, and wherein the non-replicating
probiotic micro-organisms comprise between 105 and 109 cfu/g of the composition.

US Pat. No. 9,056,293

SYSTEM AND DEVICE FOR PREPARING AND DELIVERING FOOD PRODUCTS FROM A MIXTURE MADE UP OF A FOOD LIQUID AND A DILUENT

Nestec S.A., Vevey (CH)

1. A base station for docking a metering and mixing device comprising a liquid pump, the base station comprising:
a diluent supply member;
a liquid pump drive;
an interface area for a user, comprising
a plurality of coupling members each complementing a coupling member of the metering and mixing device, the coupling members
of the base station configured to receive the metering and mixing device in a predetermined position, the coupling members
of the base station comprising a diluent coupling member and a member for coupling the liquid pump, the diluent coupling member
being complementary to a diluent intake on the metering and mixing device, the member for coupling the liquid pump being complementary
to a coupling member of the liquid pump on the metering and mixing device, and the member for coupling the liquid pump comprising
a driveshaft extending therethrough, the drive shaft attached to the base station; and

a control member for controlling a supply of diluent and for controlling the liquid pump drive member.

US Pat. No. 9,433,231

LOW TEMPERATURE EXTRUSION PROCESS AND DEVICE FOR ENERGY OPTIMIZED AND VISCOSITY ADAPTED MICRO-STRUCTURING OF FROZEN AERATED MASSES

Nestec S.A., Vevey (CH)

1. A device for a low temperature extrusion process for energy optimized, viscosity adapted micro-structuring of frozen aerated
masses, the device comprising:
at least one extruder screw that comprises a screw flight and rotates within an extruder screw channel formed by an inner
barrel wall, the extruder screw channel having an inner diameter and a length,

the length of the extruder screw channel divided into at least three zones comprising an inlet zone (I), middle zone (II),
and a final third (III), the device configured to perform a mechanical treatment of a partially frozen, aerated mass over
the length of the extruder screw channel with respect to its local viscosity, performed such that, in each of a subsequent
zone there is a dispersing of air bubbles/air cells and at the same time temperature decrease and related increase of the
frozen water fraction is achieved,

the device having a variable screw geometry along the length of the extruder screw channel locally adjusted in each of the
at least three zones according to a local viscosity with respect to efficient progressive dispersing, simultaneous progressive
temperature reduction and related freezing of water, the extruder screw comprising a screw flight height adjusted along the
length of the extruder screw channel for mass viscosity wherein, in the inlet zone (I) of the extruder screw channel, the
ratio of the screw flight height to the outer screw diameter is adjusted to between 0.03 and 0.07; in the middle zone (II)
of the extruder screw channel, the ratio of the screw flight height to the outer screw diameter is adjusted to between 0.1
and 0.15; and in the final third (III) of the extruder screw channel, the ratio of the screw flight height to the outer screw
diameter is adjusted to between 0.1 and 0.25.

US Pat. No. 9,322,821

P-CRESOL SULPHATE AS A BIOMARKER FOR HEALTHY AGING

NESTEC S.A., Vevey (CH)

1. An in vitro method of diagnosing a lifestyle that allows a subject to delay and/or avoid an ageing related chronic inflammatory
disorder, comprising
determining a level of p-cresol sulphate (PSC) in a urine sample obtained from the subject after a change in lifestyle has
been made, and

comparing the subject's PCS level to a predetermined reference value,
wherein the predetermined reference value is based on a urine PCS level obtained from the subject before the change in lifestyle,
wherein the subject is a human adult of at least 45 years of age,
wherein the ageing related chronic inflammatory disorder is atherosclerosis, arthritis, dementia, type 2 diabetes, or osteoporosis,
and

wherein an elevated urine PCS level in the sample compared to the predetermined reference value indicates an increased likelihood
that the lifestyle allows the subject to delay and/or avoid the ageing related chronic inflammatory disorder.

US Pat. No. 9,309,492

DERIVATIVE OF THE LACTOBACILUS JOHNSONII STRAIN CNCM I-1225, DEFICIENT IN D-LACTIC ACID PRODUCTION AND WITH AN IMPROVED SHELF LIFE

Nestec S.A., Vevey (CH)

1. A method for the treatment or prevention of disorders linked to a weakened immune system comprising administering to an
individual in need of same a composition comprising Lactobacillus johnsonii strain CNCM I-4437.
US Pat. No. 9,439,449

NUTRITIONAL COMPOSITION COMPRISING BIFIDOBACTERIUM LONGUM STRAINS AND REDUCING FOOD ALLERGY SYMPTOMS, ESPECIALLY IN INFANTS AND CHILDREN

Nestec S.A., Vevey (CH)

1. A method for reducing symptoms of allergies originating from food allergens comprising the step of administering a complete
nutritional composition comprising between 104 and 1011 colony forming units (CFU) of Bifidobacterium longum strain NCC 2705 (CNCM-I2618) per gram of dry composition to a young child below the age of three years who has experienced
at least one episode of an allergic reaction from a food allergen selected from the group consisting of milk protein, egg
protein, wheat protein, a cereal, a vegetable, a fruit, a nut, and a fish, whereby the symptoms of allergies are reduced.

US Pat. No. 9,198,536

DRIP TRAY FOR BEVERAGES DISPENSER

Nestec S.A., Vevey (CH)

1. A beverage dispenser comprising:
a beverage module having at least one beverage outlet; and
a drip tray positioned in the beverage dispenser as a drawer, the drip tray comprising:
a collecting tray, and
a filtering member positioned above at least a front part of the tray,
the drip tray comprising a lid for totally covering a back part of the tray, the lid being removable and presenting no opening,
and

the collecting tray comprising a partition wall, the partition wall being positioned under a front extremity of the lid and
comprising at least one slit.

US Pat. No. 9,371,175

CAPSULE FOR USE IN A BEVERAGE PREPARATION MACHINE

Nestec S.A., Vevey (CH)

1. A capsule defining a chamber for enclosing a mass of soluble and/or extractable food material, for use in a beverage preparation
machine, the capsule comprising:
capsule side walls;
a top membrane comprising a laminate that comprises superimposed layers, the superimposed layers comprising a polypropylene
layer, a polyethylene layer, and at least one elastic silicone layer, the laminate is pierceable by a fluid injection member
of the beverage preparation machine which is adapted to inject an extraction liquid under pressure inside the chamber;

a bottom wall; and
an opening member adapted to open the chamber by relative engagement with the bottom wall under the effect of the liquid pressure
increase in the chamber during injection of the extraction liquid,

the at least one elastic silicone layer having a tensile strength greater than 1 MPa and an elongation at break greater than
100%, such that the top membrane recloses in a leaktight manner after the fluid injection member has been removed therefrom,
and lamination in an area of the laminate where the fluid injection member pierces the top membrane has a weaker adhesion
relative to other areas of the laminate.

US Pat. No. 9,278,843

MIXING NOZZLE FITMENTS

Nestec S.A., Vevey (CH)

1. A dispensing device comprising:
a concentrate container;
a tube attached to the concentrate container;
a pump operatively connected to the tube;
a mixing nozzle fitment comprising
a first shaft defining an inlet passage,
a second shaft comprising a first end comprising a fluid outlet of the fitment, and the second shaft is attached to the first
shaft at a second end of the second shaft, defines a curved outlet passage that extends from the first end to the second end,
and is continuously curved from the first end to the second end, and

a coupling member attached to the second shaft and defining a passage that leads into the curved outlet passage of the second
shaft, the tube removably attached to the coupling member; and

a diluent dispensing nozzle removably attached to the first shaft of the mixing nozzle fitment.

US Pat. No. 9,351,603

ASSEMBLY OF FLOWMETER TO PCB IN A BEVERAGE MACHINE

Nestec S.A., Vevey (CH)

1. A flowmeter comprising:
an outermost casing containing a measuring chamber;
an outermost face on the outermost casing;
a generator for generating at the outermost face a signal representative of a flow through the measuring chamber; and
a connection arrangement for fastening the outermost casing against a PCB which extends over and beyond the outermost casing
and contains a sensor that is located at the outermost face and that can sense the signal from the generator upon connection,
the PCB being a controller board of a beverage preparation machine, which is configured to instruct components of the beverage
preparation machine to prepare a beverage; and

the connection arrangement is configured for creating a connection against the PCB, that is distinct from the sensor.
US Pat. No. 9,250,243

DRUG SELECTION FOR LUNG CANCER THERAPY USING ANTIBODY-BASED ARRAYS

NESTEC S.A., Vevey (CH)

1. A method for selecting a suitable anticancer drug for the treatment of a lung tumor, the method comprising:
(a) lysing cells isolated from the lung tumor after administration of an anticancer drug, or prior to incubation with the
anticancer drug, to produce a cellular extract;

(b) detecting an activation state of one or more analytes in the cellular extract using an assay comprising a plurality of
dilution series of capture antibodies specific for the one or more analytes, wherein the activation state is a phosphorylation
state, wherein the capture antibodies are restrained on a solid support, wherein the assay comprises:

(i) incubating the cellular extract with the plurality of dilution series of capture antibodies to form a plurality of captured
analytes;

(ii) washing and then incubating the plurality of captured analytes with detection antibodies comprising a plurality of activation
state-independent antibodies and a plurality of activation state-dependent antibodies specific for the corresponding analytes
to form a plurality of detectable captured analytes,

wherein the activation state-independent antibodies are labeled with a facilitating moiety,
wherein the activation state-dependent antibodies are labeled with a first member of a signal amplification pair, and
wherein the facilitating moiety, which is glucose oxidase, generates an oxidizing agent which channels to and reacts with
the first member of the signal amplification pair, which is a peroxidase in proximity to the glucose oxidase;

(iii) incubating the plurality of detectable captured analytes with a second member of the signal amplification pair to generate
an amplified signal; and

(iv) detecting the amplified signal generated from the first and second members of the signal amplification pair; and
(c) determining whether the anticancer drug is suitable or unsuitable for the treatment of the lung tumor by comparing the
activation state detected for the one or more analytes with a reference activation profile generated in the absence of the
anticancer drug.

US Pat. No. 9,192,179

METHODS FOR PROMOTING GUT MICROBIOTA BALANCE

Nestec S.A., Vevey (CH)

1. A method of promoting gut microbiota balance, the method comprising administering to an individual in need of such treatment
an effective amount of a nutritional composition comprising a fructo-oligosaccharaide (FOS) in an amount of about 35 to about
44% by weight, a polysaccharide that is not partially hydrolysed guar gum (PHGG) in an amount of about 38% to about 50% by
weight, inulin in an amount of 12 to 24% by weight; and the FOS and polysaccharide are present in a weight ratio of 62:38
to 38:62; and the FOS and inulin are present in a weight ratio of 82:18 to 58:42.

US Pat. No. 9,456,960

SEMI-RIGID PARTIALLY COLLAPSIBLE BOTTLES

Nestec S.A., Vevey (CH)

1. A bottle comprising:
a rigid wall; and
a semi-rigid wall, the semi-rigid wall being so constructed and arranged to conform to an inner side of the rigid wall in
a collapsed form, the rigid and semi-rigid walls having the same shape, and the semi-rigid wall being collapsible upon the
application of a pressure of from about 15 mBar to about 80 mBar and comprises a surface area greater than a surface area
of the rigid wall;

a neck formed from the rigid wall;
an air tight cap attached to the neck, the air tight cap including a passageway configured to be connected to a feeding assembly
or tube, the neck and the air tight cap defining a longitudinal axis, and the semi-rigid wall so constructed and arranged
to collapse along a direction substantially perpendicular to the longitudinal axis; and

a base, and the bottle has a volume ranging from about 100 to 5000 mL.

US Pat. No. 9,451,846

CAPSULE FOR USE IN A FOOD PREPARATION MACHINE

NESTEC S.A., Vevey (CH)

1. A capsule for containing a food ingredient, adapted for use in a food preparation machine able to inject a fluid under
pressure inside the capsule to prepare a food product, the capsule comprising:
a capsule body with side walls;
a top wall;
an impermeable flexible pierceable bottom membrane; and
a rigid support structure located adjacent and outside of the flexible pierceable bottom membrane, the rigid support structure
comprising (1) a planar support area that contacts at least the center of the membrane, and (2) one or more windows in the
same horizontal plane as the support area.

US Pat. No. 9,409,690

CONTAINER AND POUCH

Nestec S.A., Vevey (CH)

1. A pouch comprising:
at least two side walls;
vertical folding lines between the at least two side walls;
a top comprising flaps configured to fold around distal ends of side walls of a container while the distal ends of the container
side walls are accommodated by a closure of the container in which the pouch is arranged;

flap folding lines between the at least two side walls and the flaps; and
a reinforcement tongue formed by curvilinear cuts each extending between the flap folding lines and an edge of the at least
two side walls of the pouch, respectively, according to an angle between the vertical folding line and a tangent to the respective
curvilinear cut that goes through an extremity of the reinforcement tongue, the angle being between 10° and 45°, the reinforcement
tongue comprising a first portion extending from a first of the at least two side walls, a second portion extending from a
second of the at least two side walls, and the first portion is integral with the second portion along a vertical axis of
the reinforcement tongue that is co-linear with a corresponding vertical folding line of the pouch.

US Pat. No. 9,192,554

USE OF CHICORIC ACID AND LACTIC BACTERIUM IN FOOD SUPPLEMENT FOR REGULATING SKIN PIGMENTATION

Nestec S.A., Vevey (CH)

1. A cosmetic method for treating and/or reducing the risk of occurrence of skin pigment disorders and/or skin imperfections
comprising administering an oral food supplement comprising an ingredient containing chicoric acid and/or derivatives thereof,
and a lactic acid bacterium and/or an enzyme capable of hydrolyzing chicoric acid and/or derivatives thereof to generate tartaric
and/or caffeic acid to an individual in need of same, wherein derivatives of chicoric acid are of the following formula:

R1, R2, R3 and/or R4 being identical or different from one another, and selected from the group consisting of H; C1-C3-alkyl; aryl; amino acids; and mono-, di- or oligosaccharides.

US Pat. No. 9,145,289

MIXING NOZZLE FITMENT AND MIXED LIQUID DISPENSER

Nestec S.A., Vevey (CH)

1. A package comprising:
a fluid container; and
a mixing nozzle fitment comprising a first hollow shaft defining an inlet passage, a second hollow shaft defining a curved
outlet passage and being attached to the first hollow shaft at a joint, and a coupling member attached to the second hollow
shaft downstream of the joint, the coupling member defining a passage that leads into the curved outlet passage of the second
hollow shaft; and a flexible tube attached to the coupling member;

the fluid container is in fluid communication with the flexible tube of the mixing nozzle fitment.
US Pat. No. 9,226,945

PREVENTION OF ALLERGY AT WEANING

Nestec S.A., Vevey (CH)

1. A method for the primary prevention of allergic reactions to newly introduced dietary protein in a young mammal at weaning,
the method comprising feeding to the young mammal, during the weaning period, a therapeutic amount of a nutritional composition
comprising from 1.0 to 2.0 grams of partially hydrolyzed whey protein per 100 ml of ready to consume composition, wherein
the partially hydrolyzed whey protein has a degree of hydrolysis ranging between 15 and 25%, and 50 to 500 nanograms of TGF-?
per 100 ml of ready to consume composition.
US Pat. No. 9,173,426

METHODS FOR MANAGING WEIGHT LOSS AND BODY MASS

Nestec S.A., Vevey (CH)

1. A method for at least one of promoting weight loss by an animal, promoting weight loss by an animal while minimizing loss
of lean body mass by the animal, minimizing a reduction in energy metabolism by an animal, reducing the risk of regaining
weight by an animal after weight loss, and ameliorating undesirable animal behaviors associated with reduced caloric intake,
the method comprising:
feeding the animal for a first period a first diet containing calories that meet the animal's maintenance energy requirements;
and

feeding the animal for a second period a second diet containing calories that do not meet the animal's maintenance energy
requirements;

wherein the first period and the second period are periods of different durations and wherein the first period and the second
period are independently selected from the group consisting of two days, three days, four days, five days, six days, a week,
two weeks, and three weeks.

US Pat. No. 9,351,504

FROZEN CONFECTIONERY PRODUCT WITH LAYERED STRUCTURE AND APPARATUS FOR MANUFACTURING SAME

Nestec S.A., Vevey (CH)

1. A method for manufacturing a frozen confectionery product comprising:
directing chocolate through a first passage of an apparatus while directing ice cream through a second passage of the apparatus
and while insulating the first passage from the second passage such that the first passage only joins the second passage at
an outlet port of the first passage, the apparatus comprising a nozzle comprising the outlet port of the first passage and
an outlet port of the second passage; and

simultaneously extruding the chocolate through the outlet port of the first passage and the ice cream through the outlet port
of the second passage, the ice cream and the chocolate simultaneously extruded into a container while the nozzle and the container
are rotated with respect to each other, and the distance between the nozzle and the container is increased by a vertical movement
of either the container or the nozzle.

US Pat. No. 9,314,490

BIOLOGICAL EFFECTS OF COMPOSITIONS OF ROSMARINIC ACID

Nestec S.A., Vevey (CH)

1. A composition formulated for oral administration and comprising a bioefficiency enhancing agent consisting of rosmarinic
acid in combination with a hydrolysis effective amount of a hydrolytic enzyme selected from chlorogenate esterase or a microorganism
containing or producing a hydrolytic enzyme of an esterase;
wherein the microorganism is selected from the group consisting of Lactobacillus johnsonii (CNCM 1-1225), Bifidobacterium longum (ATCC BAA-999), Bifidobacterium lactis (CNCM 1-3446) and mixtures thereof;

so that the rosmarinic acid is hydrolysed into caffeic acid and 3,4-dihydroxy phenyllactic acid in amounts sufficient to enhance
the bioefficiency of the composition after consumption compared to non-hydrolysed rosmarinic acid containing compositions,
wherein the microorganism is a probiotic and is present in an amount ranging from 1×103 to 1×108 cfu/g.

US Pat. No. 9,308,228

SUPPLEMENTION OF MATERNAL DIET

Nestec S.A., Vevey (CH)

1. A method for normalizing plasma glucose concentration, the method comprising administering to a woman in at least the third
trimester of pregnancy a therapeutically-effective amount of a composition comprising a probiotic mixture of Lactobacillus rhamnosus CGMCC 1.3724 and Bifidobacterium lactis CNCM I-3446.

US Pat. No. 9,301,640

BEVERAGE PREPARATION MACHINE

Nestec S.A., Vevey (CH)

1. A beverage preparation machine comprising a machine body and a machine dispensing head, the dispensing head and machine
body comprising cooperating members that allow movement of the head relative to the body along a non-linear path, and such
that the trim of the dispensing head is constant whatever its position, the cooperating members comprise cooperating gears
with at least a movable gear wheel of the dispensing head, a stationary gear wheel of the machine body, and movable intermediate
linking gear wheels, the centers of which are positioned on a lever element which is rotationally movable around the central
axis of the machine gear wheel, and the gear wheels have identical gear wheel modules, and the pitch diameters of the dispensing
head and machine body gear wheels, are identical.
US Pat. No. 9,271,958

AMINO ACID SUPPLEMENTATION FOR A HEALTHY MICROBIOTA ECOSYSTEM

Nestec S.A., Vevey (CH)

1. A method for stimulating the immune defenses in a human or animal in need of same, the method comprising:
orally administering to the human or animal a food product comprising free amino acids, wherein Serine. Proline, and Threonine
are onoly added free amino acids in the food product.

US Pat. No. 9,265,376

DEVICE AND METHOD USING CENTRIFUGATION FOR EXTRACTING A LIQUID AND HEAT LOSS COMPENSATING MEANS

Nestec S.A., Vevey (CH)

1. A beverage production device for preparing a liquid extract by interaction between a liquid and food ingredients to form
the liquid extract by centrifugation of the liquid passing through the ingredients, comprising:
a centrifugal brewing unit for receiving the food ingredients,
a collecting unit for collecting the liquid extract centrifuged outside the centrifugal brewing unit, with the collecting
unit having an impact wall forming a surface of impact for the centrifuged liquid extract and a receiving cavity which is
a member that is separate from and is located below the impact wall for receiving the liquid extract impacted on the impact
wall,

driving means connected to the centrifugal brewing unit for driving the centrifugal brewing unit in rotation,
liquid supply means being connected to the centrifugal brewing unit to supply liquid in the centrifugal brewing unit,
a heater for heating the liquid supplied in the centrifugal brewing unit to a brewing temperature, and
additional heating means arranged to heat the liquid extract;
wherein the additional heating means is separated from the heater and includes a heating element that is (a) in contact with
the receiving cavity or (b) is a thermoblock located below the impact wall and below but in thermal association with the receiving
cavity, wherein the heating element of (a) or (b) provides heat to the extract in the receiving cavity after its formation
and collection without heating the impact wall, so that the liquid extract leaving the centrifugal brewing unit has a temperature
that is near the temperature of the liquid supplied to the centrifugal brewing unit.

US Pat. No. 9,242,387

FROZEN CONFECTIONERY PRODUCT WITH A PEELABLE GEL COATING AND METHOD FOR MANUFACTURING SAME

Nestec S.A., Vevey (CH)

1. A frozen confectionery product comprising:
a core comprising a frozen confection, the core is at least partially coated with a frozen flexible edible gel layer, the
gel layer is provided with at least one line cut therein extending spirally over the gel layer, the line cut therein allowing
the gel layer to peel off in one piece in a continuous spiral.

US Pat. No. 9,049,960

ONE HAND CARRIABLE LIQUID FOOD OR BEVERAGE MACHINE

Nestec S.A., Vevey (CH)

1. A machine for preparing a liquid food or beverage from a pre-portioned beverage or food ingredient, comprising:
a beverage or liquid food ingredient capsule holder, a used capsule receptacle and a drip tray for collecting drips of beverage
or liquid food, all of which are associated with the housing and contribute to the weight of the machine;

an outermost housing that has a top part and downwardly extending sidewalls which cover and shield at least part of the beverage
or liquid food module that is arranged for receiving an ingredient and feeding a liquid from a liquid source in the machine
to the ingredient;

a pump, a heater and a piping arrangement enclosed within the outermost housing for circulating the liquid from the liquid
source, wherein the outermost housing has a rear wall adjacent a liquid reservoir external to the outermost housing, and wherein
the liquid reservoir has one or more reservoir walls which is/are generally flush with the housing sidewalls; and

wherein the downwardly extending sidewalls have a portion that forms, together with a portion of the top part, a grip arranged
in or on the sidewalls of the housing above a center of gravity of the machine so that all weight of the machine is supported
when the machine is carried by the grip without risk of damage or deformation of the machine, with the center of gravity located
generally vertically below the grip, wherein the grip extends over a sufficient length along the sidewalls and having a circumference
such that the machine can be carried and displaced single handedly by seizure of the grip by an average size adult human hand
so that the user can safely carry the machine with one hand; and

wherein the grip that is formed by the portion of each downwardly extending sidewall is a longitudinal recess so that the
recess in one sidewall can be grasped by the thumb of the adult human's hand and the recess in the other sidewall can be grasped
by the fingers of the adult human's hand while the palm of the adult human's hand contacts the top of the machine.

US Pat. No. 9,285,369

ANTIBODY-BASED ARRAYS FOR DETECTING MULTIPLE SIGNAL TRANSDUCERS IN RARE CIRCULATING CELLS

NESTEC S.A., Vevey (CH)

1. An assay for performing a multiplex, high-throughput immunoassay having superior dynamic range, the assay comprising:
(a) incubating a cellular extract with a plurality of dilution series of capture antibodies specific for one or more analytes
in the cellular extract to form a plurality of captured analytes, wherein the capture antibodies are restrained on a solid
support;

(b) incubating the plurality of captured analytes with detection antibodies specific for the corresponding analytes to form
a plurality of detectable captured analytes, wherein the detection antibodies comprise:

(1) a plurality of activation state-independent antibodies labeled with glucose oxidase, and
(2) a plurality of activation state-dependent antibodies labeled with a first member of a signal amplification pair, wherein
the first member of the signal amplification pair is a peroxidase,

wherein glucose oxidase generates hydrogen peroxide (H2O2), which channels to and reacts with the first member of the signal amplification pair;

(c) incubating the plurality of detectable captured analytes with a second member of the signal amplification pair to generate
an amplified signal; and

(d) detecting the amplified signal generated from the first and second members of the signal amplification pair.

US Pat. No. 9,247,764

NUTRITIONAL COMPOSITION CONTAINING OLIGOSACCHARIDE MIXTURE

Nestec S.A., Vevey (CH)

1. A method for reducing the risk of obesity later in life to an infant, the method comprising administering a nutritional
composition comprising therapeutically effective amounts of an N-acetylated oligosaccharide, a galacto-oligosaccharide and
a sialylated oligosaccharide to an infant in the first six months of life.

US Pat. No. 9,242,786

METHOD AND DEVICE FOR ASEPTICALLY DISPENSING MULTIPLE PORTIONS OF A FLUID

Nestec S.A., Vevey (CH)

1. A method for dispensing multiple portions of a fluid stored in a container comprising a port and a flexible dispensing
tube having an inlet and an outlet, the inlet being sealed to the port and a valve being mounted in the outlet, the valve
comprising a delivery block having an input port for receiving fluid exiting the tube outlet and an internal channel beginning
at the input port and terminating in at least one output port, an elastomeric membrane for enveloping the delivery block such
that a portion of the elastomeric membrane covers the output port and the downstream end of the elastomeric membrane forms
the valve outlet, the method comprising:
a compression step during which a first portion of the flexible dispensing tube is compressed such that the fluid is compressed
and forced downstream through the internal channel of the valve delivery block and the compressed fluid extends the elastomeric
membrane at the output port and is able to flow between the elastomeric membrane and the delivery block and reach the valve
outlet;

inactivating the peristaltic pump, wherein a second portion of the tube located downstream of the first portion is filled
with the fluid from upstream; and

releasing a first pressure between the first tube portion and the valve within one second of inactivating the peristaltic
pump, by rotating a peristaltic pump in a direction opposite to the pumping direction, wherein during the release of the first
pressure between the first portion and the valve, at least a portion of the fluid present between the second portion and the
valve is dispensed into the valve to establish a second pressure in the second portion that closes the output port with the
elastomeric membrane.

US Pat. No. 9,227,777

CAPSULE CONTAINING NUTRITIONAL INGREDIENTS AND METHOD OF DELIVERY OF A NUTRITIONAL LIQUID FROM THE CAPSULE

Nestec S.A., Vevey (CH)

1. A capsule for use in a beverage production device, the capsule containing ingredients for producing a nutritional liquid
when a liquid is fed into the capsule at an inlet face thereof, the capsule comprising:
heat sensitive bioactive components selected from the group consisting of probiotic microorganisms, lactoferrin, immunoglobulins,
milk fat globule membrane fractions (FGM), growth factors, DHA, DGLA and combinations thereof, and

the heat sensitive bioactive components are physically separated from at least a part of the ingredients by at least one separation
wall which has a characteristic selected from the group consisting of permeability to a liquid and impermeability to a liquid,
the separation wall extending longitudinally in the capsule in a direction of the flow path in the capsule from the inlet
face to an outlet face.

US Pat. No. 9,149,129

CAPSULE LOADING DEVICE FOR FEEDING A CAPSULES DISPENSING MACHINE

Nestec S.A., Vevey (CH)

1. Capsule loading device comprising:
a detachable tube comprising stacked capsules, the tube having an opening for the capsules to pass through the tube, the capsules
being stacked in a single straight line relative to each other and the opening such that the capsules and the opening are
substantially co-linear;

an alignment member for aligning the tube allowing the tube to be aligned with a capsule receiving zone for receiving the
capsules as they descend by gravity, the alignment member comprising means for retaining the capsules in a stack when the
tube is moved with its opening oriented downwards, in a direction of a position in which the tube is aligned with the capsule
receiving zone, the tube being detachable from the alignment member, the means for retaining the capsules comprising an arc
shaped retention surface; and

a guiding member configured to cause the tube to pivot about an axis of rotation and forming a tube support into which the
top end of the tube is inserted, the tube support being mounted rotatably about the axis of rotation on a base of the alignment
member comprising two lateral wings positioned on either side of the retention surface, the capsule receiving zone comprising
a tube portion forming a junction with the tube support when the tube is aligned with the capsule receiving zone, and the
tube portion of the capsule receiving zone forming a buffer storage housing to receive capsules.

US Pat. No. 9,392,901

CAP EXTRACTION DEVICE

Nestec S.A., Vevey (CH)

1. A device for extraction of a capsule, the device comprising:
a first part;
a second part which is mobile relative to the first part;
a receptacle for the capsule, which, in a first position of closure of the second, mobile part against the first part, defines
a position of extraction of the capsule according to an axis in the receptacle;

a part for introduction and positioning, comprising guide means for guiding the capsule, which are arranged to insert the
capsule by gravity, and to position the capsule in an intermediate position; and

a system for flow of a drink, the second, mobile part being configured to displace the capsule from the intermediate position
to the position of extraction during closure of the device,

the system for flow of a drink comprises stop means, the stop means comprise a first stop member and a second stop member,
the guide means comprise a first guide member on which the first stop member is positioned and a second guide member on which
the second stop member is positioned, and the first and second guide members are opposed elements pivotable independently,
the second, mobile part acting on an opening of the stop means to move the stop means apart from each other during passage
of the capsule from the intermediate position to the position of extraction.

US Pat. No. 9,271,598

METHOD FOR PREPARING A FOOD LIQUID CONTAINED IN A CAPSULE BY CENTRIFUGATION AND DEVICE ADAPTED FOR SUCH METHOD

Nestec S.A., Vevey (CH)

1. A method for preparing a food liquid from a food substance contained in a sealed, single-use capsule, in a liquid food
preparation device comprising a water injection head for injecting water in the capsule and a capsule holder for holding the
capsule in the device; the capsule configured for removable insertion in the capsule holder and comprising a cup shaped body
covered by a sealing lid that has a peripheral rim by passing water through the substance, the method comprising:
piercing the sealing lid of the sealed capsule by a piercing member of a water injector of the water injection head and introducing
water by the water injector into a generally central portion of the capsule,

forming a series of liquid delivery outlets by a series of additional piercing members in the sealing lid of the capsule at
the periphery of the sealing lid near the peripheral rim of the body,

after the outlets are formed in the lid of the capsule, centrifugally rotating the capsule about its central axis for passing
water outwardly from the generally central portion through the substance and then toward the liquid delivery outlets of the
lid to form the food liquid,

delivering the food liquid as several streams of liquid from the delivery outlets formed in the lid of the capsule, and
passing the food liquid delivered from the capsule through a restriction valve and wherein the restriction valve opens when
a certain pressure is exerted by centrifuged food liquid on the restriction valve.

US Pat. No. 9,131,721

GUT MICROBIOTA IN INFANTS

Nestec S.A., Vevey (CH)

1. A method of manufacturing a nutritional composition, the method comprising:
combining at least whey protein, a phosphorus source, lactose, water, a fat source having a ratio of n-6 to n-3 fatty acids
ranging from about 5:1 to about 15:1, and an ingredient selected from the group consisting of lactoferrin, probiotics and
a combination thereof to form a liquid composition, wherein the liquid composition has a phosphorus content of less than 40
mg/100 kcal and a protein content of less than 2.1 g protein/100 kcal, wherein the whey protein is a predominant protein of
the protein content, the protein content includes partially hydrolyzed proteins having a degree of hydrolysis between 2 and
20%, and the whey protein has an extent of lysine blockage that is less than 10% by weight of lysine; and

spray drying or freeze drying the liquid composition to form a powder having a moisture content of less than about 5% by weight.

US Pat. No. 9,084,510

BEVERAGE DISPENSER WITH WHIPPER ASSEMBLY

Nestec S.A., Vevey (CH)

1. A beverage dispenser comprising:
a frame for supporting the components of the dispenser;
a whipper assembly comprising a whipper housing, a whipper device and a back wall, the whipper housing and the back wall forming
a whipper chamber in which is housed the whipper device,

a drive shaft for driving the whipper device, the drive shaft being supported by the frame,
a detachable connection for attaching the back wall to the whipper housing, and
the dispenser comprises a detachable connection member for attaching the whipper housing to the frame.

US Pat. No. 9,173,937

PROBIOTICS, SECRETORY IGA AND INFECTION

Nestec S.A., Vevey (CH)

1. A method for treating non-viral infections, the method comprising the steps of:
administering a therapeutically-effective amount of a composition comprising isolated secretory IgA and at least one probiotic
bacteria to an individual having a non-viral infection, at least 90% of the probiotic bacteria present in the composition
being associated with at least one SIgA molecule as immune complexes.

US Pat. No. 9,102,464

COFFEE CAPSULE WITH A DEFORMABLE SEALING ELEMENT

Nestec S.A., Vevey (CH)

1. A portion packaging for receiving a substance to produce a drink comprising a capsule having:
a cavity with an opening for receiving a substance and,
a side wall at said opening,
an outwardly protruding edge which is integrally formed on the side wall at said opening,
a film, and
a deformable sealing element which is integrally formed with the outwardly protruding edge, wherein said opening is closable
by the film and wherein the deformable sealing element comprises a rollover edge having an essentially elliptical or oval
cross-sectional shape defining an open interior cavity that facilitates deformation, and having a greater height than width,

wherein at least a portion of the rollover edge is configured to be irreversibly deformed when producing the drink, and the
rollover edge is integrally formed with a plurality of edge portions on an outer border of the protruding edge, with a first
edge portion having a rounded shape and protruding downwards, a second edge portion being integrally formed on the first edge
portion such that the second edge portion is arranged essentially at right angles to a surface of the protruding edge, a third
edge portion being integrally formed on the second edge portion and having a rounded shape, and a fourth edge portion being
integrally formed on the third edge portion with the fourth edge portion extending essentially parallel to the second edge
portion and either being connected to the outer border of the protruding edge as said sealing element is deformed or being
free-standing when said sealing element is not deformed, the fourth edge portion comprising a free end configured such that
deformation of the deformable sealing element surrounds the free end by the four edge portions.

US Pat. No. 9,301,902

EXPANDABLE CONTAINER FOR PREPARATION OF A NUTRITIONAL COMPOSITION

Nestec S.A., Vevey (CH)

1. A container for preparing of a nutritional composition from a powdered or concentrated liquid nutritional formula base
upon hydration with supplied liquid, the container comprising:
an adaptor comprising a liquid inlet positioned therewithin, an engagement member for connecting the container to a matching
engagement member of a liquid dispenser, and an inner membrane that covers the liquid inlet, the inner membrane comprising
an outlet aperture in a different portion of the inner membrane relative to where the liquid inlet intersects the inner membrane;
and

a compartment for containing a predefined amount of powdered or concentrated liquid nutritional formula base for the preparation
of the nutritional composition upon hydration with the supplied liquid, the compartment comprising a flexible wall portion
and a non-deformable neck portion with an opening connected to the adaptor;

the flexible wall portion being expandable in a manner that the volume of the compartment increases from a retracted position
to an expanded position allowing a sufficient volume of liquid to be supplied into the compartment through the liquid inlet
for the preparation of the nutritional composition;

wherein the liquid inlet communicates with the opening of the compartment and comprises at least one conduit to be supplied
with liquid from the liquid dispenser, and the adaptor further comprises a liquid outlet communicating with the opening of
the compartment at a different location relative to the liquid inlet and which is configured to release liquid from the compartment
of the container to the exterior thereof.

US Pat. No. 9,452,575

LABELED CONTAINERS AND PROCESSES FOR PRODUCING

Nestec S.A., Vevey (CH) ...

1. A process for producing an in-mold labeled container, the process comprising:
setting a multilayered label comprising an oxygen absorbing resin layer onto an inner wall surface of a female mold part,
the oxygen absorbing resin layer is a sublayer in a multilayered oxygen barrier layer, the multilayered oxygen barrier layer
further comprising at least one oxygen barrier resin sublayer, the multilayered label further comprising at least one moisture
resistant resin layer as the outermost layer or both the outermost and innermost layers of the multilayered label, the total
thickness of one or more layers layered outside the multilayered oxygen barrier layer is represented by X and the total thickness
of the container is represented by Y, the ratio of X/Y is from 0.06 to 0.1; and

injecting a melted resin that is polypropylene into a cavity between the female mold part and a male mold part, thereby molding
and labeling the container simultaneously.

US Pat. No. 9,443,373

BEVERAGE PREPARATION MACHINE COMPRISING AN EXTENDED USER-ADVISORY FUNCTIONALITY

Nestec S.A., Vevey (CH)

1. A beverage preparation machine having an extended user-advisory functionality, the beverage preparation machine comprising:
an ingredient processing arrangement comprising a liquid reservoir and a brewing unit configured to allow introduction, extraction
and removal of a capsule containing ground coffee, and the beverage preparation machine comprises a beverage outlet from which
a beverage prepared from the capsule is dispensed;

a control unit configured to recognize an actual or upcoming event triggering the extended user-advisory functionality and
configured to control powering of a heater and a pump of the beverage preparation machine;

a communication module configured to communicate with a remote external device via a communication network; and
a display configured to display messages;
the control unit in the extended user-advisory functionality is adapted (i) to establish a connection via the communication
module to the remote external device, the remote external device is offering a resource for managing the actual or upcoming
event, and (ii) to control the display of a message on the display indicating the actual or upcoming event and advising a
user on managing the actual or upcoming event,

the actual or upcoming event comprises an actual or upcoming disturbance, and the actual or upcoming disturbance is a disturbance
related to scaling and malfunctioning of a component of the beverage preparation machine.

US Pat. No. 9,393,253

FOOD COMPOSITION COMPRISING GLUCOSAMINE

Nestec S.A., Vevey (CH)

1. A method for treating osteoarthritis in a mammal in need thereof comprising:
orally administering to the mammal in need thereof a composition comprising an effective amount of dried plant material obtained
by: drying plant material, wherein the plant material has a maximum width of 5 cm and is in the form of slices, cubes, or
a combination thereof, and wherein said plant material is dried at a temperature between 80° C. and 105° C. over a period
of 5 hours to 50 hours, wherein the dried plant material has a glucosamine content in an amount greater than 150 mg/kg dry
matter of the dried plant material, and wherein the plant material is selected from the group consisting of chicory, carrot,
Jerusalem artichoke and beet.

US Pat. No. 9,375,454

INFANT FEEDING FORMULAS COMPRISING PROBIOTIC MICRO-ORGANISMS

Nestec S.A., Vevey (CH)

1. An infant feeding formula to be administered to infants as an only nutrition source or as a complementary nutrition source
in addition to breastfeeding, to provide complete nutrition to the infant and also comprising non-replicating probiotic micro-organisms
rendered non-replicating by a heat treatment at 120 to 140° C. for 5-15 seconds, the non-replicating probiotic micro-organisms
selected from the group consisting of Bifidobacterium longum NCC 2705, Bifidobacterium breve NCC 2950, Lactobacillus johnsonii La1, Lactobacillus reuteri DSM17938, Lactobacillus reuteri ATCC55730, Streptococcus thermophilus NCC 2019, Streptococcus thermophilus NCC 2059, Lactobacillus casei NCC 4006, Lactobacillus acidophilus NCC 3009, Lactobacillus casei ACA-DC 6002 (NCC 1825), Escherichia coli Nissle, Lactobacillus bulgaricus NCC 15, Lactococcus lactis NCC 2287, and combinations thereof, wherein the non-replicating probiotic micro-organisms induce less pro-inflammatory cytokines
while maintaining or inducing additional Interleukin 10 (IL-10) production relative to live counterpart.

US Pat. No. 9,056,691

BAG DEFLATION DEVICES AND METHODS FOR DEFLATING BAGS

Nestec S.A., Vevey (CH)

1. A bag deflating device comprising:
a first gripper having a first end and a second end opposite to the first end;
a first mechanical finger attached to the first gripper and constructed and arranged to move with the first gripper, the first
mechanical finger comprising an elongated rod and a support plate attached to the elongated rod and defining at least one
aperture;

a second gripper opposing the first gripper, having a first end and a second end opposite to the first end, and the first
end of the first gripper is pivotally connected to the first end of the second gripper such that the second ends pivot toward
each other and away from each other; and

a second mechanical finger attached to the second gripper and constructed and arranged to move with the second gripper, the
second mechanical finger comprising an elongated rod and a support plate attached to the elongated rod and defining at least
one aperture,

the first and second grippers are configured to hold a bag by gripping a first portion of the bag, the holding of the bag
between the first and second grippers comprises rotating the first and second grippers toward each other to grip the first
portion of the bag between the first and second grippers,

the first and second mechanical fingers are configured to compress a second portion of the bag between the first mechanical
finger and the second mechanical finger to deflate the bag, and the second portion of the bag is lower on the bag relative
to the first portion of the bag.

US Pat. No. 9,149,152

ERGONOMIC DISPENSER INTERFACE

Nestec S.A., Vevey (CH)

1. A machine for preparing a beverage comprising:
a beverage preparation module for processing one or more beverage ingredients and for dispensing a beverage resulting therefrom;
a unit for controlling the processing in accordance with a parameter set to a value stored in the unit;
a user-interface connected to the control unit for acquiring the value from a user and storing the value in the control unit,
the user-interface comprising a first user-selector associated with a first value for the parameter and a second user-selector
associated with a second value for the parameter,

the first and second user-selectors each comprises a user-actuation adjustment direction for shifting, on user-actuation in
the adjustment direction, the value associated with the user-selector to a user-selected adjusted value selected from a range
of values associated with the user-selector,

the first and second user-selectors each comprises a user-actuation initiation direction for initiating, on user-actuation
in the initiation direction, an action selected from the group consisting of (i) the control unit storing the user-selected
adjusted value as the stored value; and (ii) the processing of the one or more beverage ingredients in accordance with the
parameter set to the user-selected adjusted value as the stored value, and

the parameter for which the first value set by the first user-selector and the second value set by the second user-selector
is a volume of the beverage to be dispensed from the processing.

US Pat. No. 9,351,503

FROZEN CONFECTIONERY PRODUCT WITH A PEELABLE GEL COATING AND METHOD FOR MANUFACTURING SAME

Nestec S.A., Vevey (CH)

1. A frozen confectionery product comprising:
a core comprising a frozen confection, the core is at least partially coated with a frozen flexible edible gel coating, the
gel coating being provided with at least one cutting line allowing one to peel-off the gel-coating at least partially, the
gel coating comprises at least two successive gel layers in contact with each other; wherein the gel layers are visually distinct
from each other and at least one of the visually distinct gel layers is frozen separately from another visually distinct gel
layer so as to be peeled off the core separately relative to each other.

US Pat. No. 9,351,510

STABLE THICKENER FORMULATIONS

Nestec S.A., Vevey (CH)

1. A stable thickener formulation for use in a nutritional composition, the stable thickener formulation comprising:
from about 0.1% to about 0.14% by weight of xanthan gum;
from about 2.5% to about 2.7% by weight of starch; and
at least one nutritional ingredient, wherein the post-process viscosity of the formulation is from 1100 cps to 4000 cps, wherein
the formulation has a stable viscosity over a 210 day period at 4° C., wherein a caloric density of the composition is one
of about 1.2 cal/ml and about 1.5 cal/ml, and wherein the nutritional ingredient comprises at least one ingredient selected
from the group consisting of a carbohydrate, a protein, a fat, prebiotics, probiotics, synbiotics, fish oils, phytonutrients,
antioxidants, vitamins, minerals and combinations thereof.

US Pat. No. 9,314,128

EXTRACTION SYSTEM FOR THE PRODUCTION OF A DRINK USING A CAPSULE

Nestec S.A., Vevey (CH)

1. A system for preparing drinks, the system comprising:
a capsule containing a dose of ingredients, the capsule including a body in the form of a truncated cone comprising an injection
face and an extraction face with an opening on the wider side and terminating in a collar, a portion for delivery of the drink
closing at least partially the opening in the body; the collar comprising a base portion connected to the body and terminating
in a free edge; the collar of the capsule comprising a seal fitted to or forming an integral part of the collar; and

a device for preparing drinks, the device comprising:
a frame,
a guide for allowing the capsule to be inserted into the device,
a first chamber portion comprising a cavity of a shape suitable for covering the body of the capsule, a liquid injector and
a clamping edge which interacts in engagement with the seal of the collar,

a second chamber portion comprising an extraction plate,
at least one of the two chamber portions being able to move relative to the other chamber portion from an open position in
which the capsule is inserted to a closed position in which the capsule is enclosed between the two chamber portions,

the first chamber portion comprising a hook member for hooking the capsule making it possible to keep the capsule in the cavity
of the first chamber portion during the transition from the closed position to the open position, the capsule comprising a
complementary member suitable for attaching to the hook member, and

a release mechanism configured to release the capsule by acting on at least one of the capsule and the hook member in order
to release the capsule from the first chamber portion, the capsule then being able to fall by its own weight, the release
mechanism comprising an abutment surface in the frame configured to contact the free edge of the collar and further comprising
a lateral recess in the frame positioned to allow the hook member to pass while the collar of the capsule is stopped by the
abutment surface.

US Pat. No. 9,274,116

DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS

NESTEC S.A., Vevey (CH)

1. A method for selecting a suitable anticancer drug for the treatment of a breast tumor, the method comprising:
(a) incubating cells isolated from a breast tumor with an anticancer drug in vitro;
(b) lysing the incubated cells to produce a cellular extract;
(c) detecting an activation state of one or more analytes in the cellular extract using an assay comprising a plurality of
dilution series of capture antibodies specific for the one or more analytes, wherein the capture antibodies are restrained
on a solid support, and wherein the assay comprises:

(i) incubating the cellular extract with the plurality of dilution series of capture antibodies to form a plurality of captured
analytes;

(ii) incubating the plurality of captured analytes with detection antibodies comprising a plurality of activation state-independent
antibodies and a plurality of activation state-dependent antibodies specific for the corresponding analytes to form a plurality
of detectable captured analytes,

wherein the activation state-independent antibodies are labeled with glucose oxidase, wherein the glucose oxidase and the
activation state-independent antibodies are conjugated to a sulfhydryl-activated dextran molecule, wherein the activation
state-dependent antibodies are labeled with a first member of a signal amplification pair, and wherein the glucose oxidase
generates an oxidizing agent which channels to and reacts with the first member of the signal amplification pair;

(iii) incubating the plurality of detectable captured analytes with a second member of the signal amplification pair to generate
an amplified signal; and

(iv) detecting the amplified signal generated from the first and second members of the signal amplification pair; and
(d) determining whether the anticancer drug is suitable or unsuitable for the treatment of the breast tumor by comparing the
activation state detected for the one or more analytes with a reference activation profile generated in the absence of the
anticancer drug.

US Pat. No. 9,253,993

FROZEN CONFECTIONERY PRODUCTS

Nestec S.A., Vevey (CH)

1. A method of producing a frozen confectionery product, comprising the steps of:
subjecting a composition having a pH between 5.6 and 6.5 and comprising at least 7 wt % of dairy protein comprising a protein
source selected from the group consisting of liquid fresh milk, milk powder, standardised milk powder, skimmed milk powder,
acid casein, sodium caseinate, and combinations thereof to a heat treatment at a temperature between 80° and 140° C. for a
time period of 5 seconds to 30 minutes to at least partially form protein aggregates comprising casein and whey protein;

mixing the heat treated composition with further ingredients to form an ice confectionery mix;
pasteurizing the ice confectionery mix; and
freezing the pasteurized ice confectionery mix to form the frozen confectionery product.
US Pat. No. 9,101,639

FOOD COMPOSITION COMPRISING GLUCOSAMINE

Nestec S.A., Vevey (CH)

1. A method for improving skin quality and age-related alterations of the skin, and/or for exfoliating skin, the method comprising:
applying to the skin of an individual in need thereof a cosmetic composition comprising a therapeutically effective amount
of a dried plant material,

wherein said dried plant material comprises a mixture of glucosamine and other compounds,
wherein said dried plant material is prepared by drying the raw plant material at a temperature between 80° C. and 105° C.
for a suitable time to obtain glucosamine in the dried plant material in an amount greater than 150 mg/kg of the dried plant
material, and

wherein the raw plant material is selected from the group consisting of Chicory (Cichorium intybus), carrot (Daucus carota), Jerusalem artichoke (Helianthus tuberosum), and beet (Beta vulgaris).

US Pat. No. 9,101,149

STABLE CREAMER COMPOSITION AND METHOD OF MAKING SAME

Nestec S.A., Vevey (CH)

1. A liquid creamer composition consisting of:
water, sweetener, buffer salts, protein, flavor and color;
a high oleic acid oil (i) comprising at least 50% oleic acid, no more than 30% linoleic acid, and no more than 5% linolenic
acid, (ii) selected from the group consisting of soy bean oil, canola oil, and combinations thereof;

a hydrocolloid in an amount between 0.01% and 0.5% of the liquid creamer composition; and
an emulsifier.

US Pat. No. 9,119,503

BEVERAGE BREWING UNIT

Nestec S.A., Vevey (CH)

1. A beverage machine comprising:
an outer casing containing one of a water injection assembly and a holding assembly that are relatively movable towards each
other forming a brewing unit, and providing an ingredient capsule passage which can be opened between the water injection
assembly and the holding assembly for introducing or removing an ingredient capsule and closed for brewing a beverage from
the ingredient capsule;

the passage having an opening which is arranged for guiding an ingredient capsule into the brewing unit;
a closure part associated with the outer casing, with the closure part configured and dimensioned to be larger than the passage
opening and uniformly spaced from the holding assembly that surrounds the passage opening;

such that the holding assembly is relatively movable into and out of the outer casing with a generally parallel relative movement
from:

an open relative position in which the ingredient capsule can be passed into the brewing unit via the opening;
to a closed relative position, in which the opening is closed by the closure part as the holding assembly is moved into the
outer casing to form the brewing unit.

US Pat. No. 9,084,805

SIALIC ACID TO SUPPORT THE IMMUNE SYSTEM IN THE ELDERLY

Nestec S.A., Vevey (CH)

1. A method for treating a disorder linked to an alteration of the immune system selected from the group consisting of infections,
autoimmune-like diseases, innate defence disorders, cyclic neutropenia, and combinations thereof, the method comprising administering
a therapeutically-effective amount of a composition containing a protein fraction comprising N-acetylneuraminic acid bound
to a threonine rich peptide/protein backbone to an individual having same, the protein fraction comprises at least one glycosylated
amino acid or peptide selected from the group consisting of NeuAc-?-2,3-Gal-?-1,3-(NeuAc-?-2,6-)-GalNAc-Rn, NeuAc-?-2,3-Gal-?-1,3-GalNAc-Rn, Gal-?-1,3-(NeuAc-?-2,6-)-GalNAc-Rn, and Gal-?-1,3-GalNAc-Rn, wherein R is an amino acid residue and n has a value between 1 and 10; if n has a value of 1, R is a threonine residue or
a serine residue; and if n has a value of 2 to 10, the peptide contains at least one threonine or serine residue, and at least
15 mol % of the ingredient is N-acetyl-neuraminic acid.

US Pat. No. 9,101,948

DISPENSING SUPPORT FOR GABLE TOP PACKAGING

Nestec S.A., Vevey (CH)

1. A dispensing support for use with an associated package, presenting a parallelepiped shape for its bottom and side panels
and a gable top panel with a pour spout attached thereto, the dispensing support comprising:
the dispensing support comprises a parallelepiped sleeve, the sleeve being divided in two parts attached together by a hinge,
so that the sleeve can be opened and the associated package can be inserted inside; and

the dispensing support presents an upwardly projecting spout extending from a top wall of the parallelepiped sleeve, the spout
being off-center on the top wall of the sleeve so as to engage the pour spout at the gable top panel of the package when the
package is introduced in the dispensing support with its gable top compressed.

US Pat. No. 9,440,774

CLOSURE FOR PACKAGING

Nestec S.A., Vevey (CH)

1. A closure comprising:
an insert comprising a central discharging opening and configured to be secured to a part on a packaging;
a lid connected in an articulated manner to the insert to close the discharging opening from the top; and
a tamper-evident closure that connects the lid to the insert, the tamper-evident closure having a tamper-evident element which
is connected to a grip tab of the lid via at least one predetermined break point and, in a lid-down position in which the
lid closes the discharging opening, is arranged toward a side of the closure and therefore offset with respect to the discharging
opening, the tamper-evident element is a pin comprising a first abutment at a bottom end of the pin and a second abutment
at a top end of the pin, the tamper-evident element is held between the first and second abutments on a projection of the
insert after the tamper-evident closure has been undone, the top end of the pin comprising the at least one predetermined
break point.

US Pat. No. 9,309,044

CAPSULE WITH INTEGRATED ANTIMICROBIAL FILTER

Nestec S.A., Vevey (CH)

1. A capsule for use in a beverage production device, the capsule containing ingredients for producing a nutritional liquid
when a liquid is fed into the capsule at an inlet face thereof, the capsule comprising:
an inlet face and an outlet face;
an antimicrobial filter comprising at least one microporous polymer membrane free of bacteriostatic or bactericidal material
and is supported by a backing member;

a main compartment containing at least a portion of ingredients for producing a nutritional liquid, the portion of the ingredients
in the main compartment comprising milk-based powder, and the antimicrobial filter being positioned between the outlet face
and the portion of the ingredients in the main compartment and distanced from the outlet face; and

a second compartment between the antimicrobial filter and the outlet face, the second compartment comprising probiotic microorganisms.

US Pat. No. 9,101,247

FLOWMETER ASSEMBLY FOR A BEVERAGE MACHINE

Nestec S.A., Vevey (CH)

1. A flowmeter housing for a beverage preparation machine, the flowmeter housing comprising:
a housing defining a measuring chamber, the housing comprising a first body and a second body that are rotatably assembled
together by a bayonet connector having at least two pairs of interconnecting securing parts, a first securing part of each
pair coupled to the first body and a second securing part of each pair coupled to the second body,

wherein the securing parts of each pair have cooperating shapes for interconnection thereof, the cooperating shapes of a first
pair being different from the cooperating shapes of a second pair,

wherein the first body has a rim and the second body has a seal lip, the seal lip being force-fitted into the rim, or vice
versa, for sealing the first and second bodies, and

wherein the first securing part of each pair extends vertically from the rim.
US Pat. No. 9,265,276

REDUCING ASTRINGENCY IN COMPOSITIONS CONTAINING PHENOLIC COMPOUNDS

Nestec S.A., Vevey (CH)

1. A method for reducing the astringency of a composition that comprises a catechin, the method comprising the step of adding
a phosphatidylcholine to the composition, the phosphatidylcholine and the catechin are in a weight ratio from 1:2 to 4:1.
US Pat. No. 9,549,569

NUTRITION FOR OBESE PATIENTS

Nestec S.A., Vevey (CH)

1. A method for treatment of malnutrition comprising the step of administering to an obese patient suffering from malnutrition
a nutritional composition comprising an energy density between 0.4 and 0.9 kcal/ml and, per liter, at least 500 ?g RE of Vitamin
A, 70 mg of Vitamin C, 9.0 mg ? TE of Vitamin E, 4.0 mg of zinc and 30 ?g of selenium, and the composition comprises a protein
source providing 35 to 50% of the total calories of the composition and comprising between 60 and 85% by weight whey protein,
and the nutritional composition is nutritionally complete.

US Pat. No. 9,347,682

DYNAMIC DOUBLE-CIRCUIT IN-LINE HEATER

Nestec S.A., Vevey (CH)

1. A method for controlling a heater for a liquid food or beverage preparation machine, the liquid being circulated through
the heater for brewing a food or beverage ingredient, the heater comprising: a body having an inlet, an outlet and a heating
chamber extending therebetween, the inlet, outlet and heating chamber forming together a rigid passage for guiding the liquid
circulating through the body; and a heater cooperating with the body for supplying heat into the heating chamber; and
the heater comprises (i) at least two different types of heating elements selected from the group consisting of a thick film,
a surface heating element, a heating cartridge selected from the group consisting of a cylindrical heating cartridge and a
wrapped heating cartridge, and combinations thereof; and (ii) at least two electrical control circuits for independently activating
and deactivating each heating element, wherein the heating elements are independently activated or deactivated comprising:

switching on and off the electrical control circuits, so as to avoid simultaneous switching on or off of both heating elements,
wherein one or both of the heating elements are in direct contact with the body to enable heat to be conducted directly between
the heating elements and the body.

US Pat. No. 9,260,223

REVERSIBLY DEFORMABLE INTERACTIVE PACKAGE COMPONENTS

Nestec S.A., Vevey (CH)

1. An interactive lid for a package, the lid comprising a hollow body defined by a flexible shell, wherein the shell is reversibly
deformable or comprises regions that are reversibly deformable, the lid adapted for launching or propelling an item when the
item is placed on the shell or on a reversibly deformable region of the shell, wherein when the shell is deformed and thereafter
springs back to its undeformed shape, the springing action propels the item away from the lid.
US Pat. No. 9,254,303

SYNBIOTIC MIXTURE

Nestec S.A., Vevey (CH)

1. A method for the treatment of pathogenic infections of the gastro-intestinal tract, the method comprising administering
to an individual suffering from a pathogenic infection of the gastro-intestinal tract a composition comprising a component
selected from the group consisting of N-acetyl-lactosamine and an oligosaccharide containing N-acetyl-lactosamine, and a probiotic
Lactobacillus sp, wherein the composition is administered to the individual in an amount that provides 0.1 to 3 g of the component per day
and 105 to 1012 cfu of the probiotic Lactobacillus sp per day.
US Pat. No. 9,238,015

4-OXO-2-PENTENOIC ACID AND CARDIOVASCULAR HEALTH

Nestec S.A., Vevey (CH)

1. A method for the treatment of cardiovascular disorders, the method comprising administering a non-pharmaceutical composition
comprising 4-oxo-2-pentenoic acid to a subject in need of the treatment of cardiovascular disorders, wherein the cardiovascular
disorders are selected from the group consisting of atherosclerosis, high blood pressure, coronary heart disease, myocardial
infarction, angina pectoris, stroke, heart failure, and combinations thereof.
US Pat. No. 9,506,920

ASSAYS FOR THE DETECTION OF ANTI-TNF DRUGS AND AUTOANTIBODIES

Nestec S.A., Vevey (CH)

1. A method for determining the presence or level of an autoantibody to a therapeutic antibody for treating an autoimmune
disease in a sample, the method comprising:
(a) contacting a labeled therapeutic antibody with the sample to form a labeled complex with the autoantibody;
(b) subjecting the labeled complex to size exclusion chromatography to separate the labeled complex from free labeled therapeutic
antibody and to detect an amount of the labeled complex and an amount of the free labeled therapeutic antibody; and

(c) comparing a ratio of the amount of the labeled complex and the amount of the free labeled therapeutic antibody detected
in step (b) to a standard curve of known amounts of the autoantibody, thereby determining the presence or level of the autoantibody.

US Pat. No. 9,486,004

MILK-BASED PROTEIN HYDROLYSATES AND INFANT FORMULAE AND NUTRITIONAL COMPOSITIONS MADE THEREOF

Nestec S.A., Vevey (CH)

1. A method for the induction of oral tolerance in infants or patients in need thereof, the method comprising:
treating a milk-based proteinaceous material with at least one trypsin-like endopeptidase derived from a strain of Kutzneria, and at least one chymotrypsin-like endopeptidase derived from a microorganism, the ratio of the trypsin-like endopeptidase
to the chymotrypsin-like endopeptidase being between 20:1 to 35:1 based on weight of enzyme; and

administering a composition comprising milk-based protein hydrolysate obtained by the treated milk-based proteinaceous material.

US Pat. No. 9,398,829

INTEGRATED HEATER FOR A BEVERAGE PREPARATION DEVICE

Nestec S.A., Vevey (CH)

1. An in-line heater for a liquid food or beverage preparation machine, in which machine liquid is circulated through the
heater and then guided into a brewing chamber for brewing a food or beverage ingredient supplied into said brewing chamber,
such heater comprising:
a body incorporating an inlet, an outlet and a heating chamber extending therebetween, with the inlet, outlet and heating
chamber forming together a rigid passage for guiding the liquid circulating through the body;

one or more electric components that are secured on or in the body and connected to a printed circuit board arranged to control
the heater;

wherein the one or more electric components are rigidly connected to the printed circuit board.

US Pat. No. 9,387,980

BEVERAGE CAPSULE WITH SAFETY FEATURE

Nestec S.A., Vevey (CH)

1. A capsule for the preparation of a food or a beverage by injection therein of a fluid under pressure, the capsule comprising:
a chamber containing a substance;
a bottom pierceable membrane; and
an opening member allowing the capsule to be opened by piercing the bottom membrane for allowing the food or the beverage
to flow out of the capsule, the opening member comprising a surface with a multitude of piercing elements configured to engage
the bottom membrane under the effect of the rise in pressure in the chamber, the opening member comprises at least one safety
piercing element surrounded by a safety wall such that an apex of the at least one safety piercing element is located within
the vicinity of the safety wall, at least a portion of the multitude of piercing elements are exterior to the safety wall
on an opposite side of the safety wall from the at least one safety piercing element, and a ratio of a height of the at least
one safety piercing element to a height of the safety wall is between 1:2 and 1:1.

US Pat. No. 9,301,504

ANIMAL PLAY TOY

Nestec S.A., Vevey (CH)

1. An animal play toy comprising:
a top portion defining at least two holes therethrough, the two holes having the same orientation opposite each other on the
top of the top portion; and

a weighted bottom portion attached to the top portion, the weighted bottom having an opening for dispensing of an item contained
in the animal play toy.

US Pat. No. 9,117,326

APPARATUS FOR PACKAGING DRINKING WATER

Nestec S.A., Vevey (CH)

17. A water fountain according for in-home delivery of drinkable water, the fountain comprising:
a source of drinkable water;
a stock of packages;
a filling member for filling at least one package with drinkable water; and
a sealing member for sealing individual filled packages before deliver to the consumer, wherein the package is a pre-pouch
of lower volume than a final volume, and the pouch can be heated to a temperature allowing the deformation of the material
so as to allow the filling step with the product to be conducted with a pressure of from 0.5 to 20 bar so as to deform the
pouch to its final volume before sealing of the pouch.

US Pat. No. 9,066,624

LIQUID FOOD OR BEVERAGE MACHINE HAVING A DRIP TRAY AND A CUP SUPPORT

Nestec S.A., Vevey (CH)

16. A machine for preparing liquid food or beverage from a pre-portioned beverage or food ingredient, comprising:
a liquid food or beverage module having a liquid or beverage outlet;
a collector for collecting liquid evacuated by the support device;
a first support device that is located under the beverage outlet and that has an arrangement for evacuating liquid, wherein
the first support device extends around the module or at least along a front part and one or two sides of the module; and

a second support device that is located between the first support device and the liquid food or beverage module, the second
support device is movable into an operative position between the outlet and the dispensing area for supporting a smaller recipient;

wherein the first support device comprises:
a dispensing area on or above which a recipient may be placed for collecting a liquid food or beverage dispensed from the
outlet, and

a non-dispensing area laterally adjacent to the dispensing area so that it is not underlying any liquid or beverage outlet,
with the non-dispensing area being sized and arranged to support and allow liquid drainage from multiple recipients inverted
and placed thereupon after use, and also configured for evacuating drained liquid to the collector,

wherein the non-dispensing area is larger than the dispensing area.

US Pat. No. 9,198,533

IDENTIFICATION OF BEVERAGE INGREDIENT CONTAINING CAPSULES

Nestec S.A., Vevey (CH)

1. A beverage production system comprising:
beverage ingredient containing capsules comprising an identification member; and a beverage production machine for receiving
the capsules, the machine comprising:

a means for physically contacting a capsule in order to read information thereof, the contact means comprising at least one
linearly displaceable probe that mechanically contacts the capsule at one end of the probe, the probe coupled or being part
of a resilient support member and associated to a circuitry, and the probe formed of pins which have a base embedded or inserted
in a seat of the support member, and

a control means functionally connected to the contacting means and designed to control the operation of the beverage production
machine in response to the read information, the control means initially arranged at the other end of the probe to detect
an identification information in relation to a degree of displacement of the probe in response to the probe's contact with
the capsule.

US Pat. No. 9,138,095

BEVERAGE DISPENSER WITH SAFE CLEANING ARRANGEMENT

Nestec S.A., Vevey (CH)

1. A beverage preparation machine comprising:
a housing;
a duct having an outlet;
a conduit upstream from the duct and connected thereto; and
a waste liquid collector arranged to collect waste liquid from the outlet,
the duct comprising: an operative position for circulating beverage through the conduit and along the duct and dispensing
the beverage from the outlet outside the housing above a user-receptacle filling area; and a cleaning position for circulating
cleaning fluid through the conduit and along the duct and evacuating the cleaning fluid from the outlet inside the housing
to the waste liquid collector; and

the duct is configured to pivot the outlet from an operative position into a cleaning position and is pivotally mounted to
the conduit outside the housing.

US Pat. No. 9,282,758

TUBE FEED FORMULATIONS AND METHODS FOR USING SAME

Nestec S.A., Vevey (CH)

19. A method of improving the overall health of a patient having an underlying medical condition, the method comprising:
administering to a patient having an underlying medical condition a tube feed formulation comprising a processed whole food,
a source of vitamins or minerals, at least seven different sources of macronutrients selected from the group consisting of
protein, carbohydrates, fats, and combinations thereof, and at least one of a herb or a spice to provide a tube feed formulation
that can be marketed as an ethnic-specific formulation, and the tube feed formulation has a caloric density of 0.5 to 0.8
kcal per ml and an osmolality up to 400 mOsm/kg water.

US Pat. No. 9,201,064

PHENYLACETYLGLUTAMINE AS A BIOMARKER FOR HEALTHY AGING

NESTEC S.A., Vevey (CH)

1. A non-invasive method of diagnosing a lifestyle that allows a subject to delay and/or avoid an ageing related chronic inflammatory
disorder, the method comprising:
determining a level of phenylacetylglutamine (PAG) in a urine sample obtained from the subject after a change in lifestyle
has been made and

comparing the subject's PAG level to a predetermined reference value,
wherein the predetermined reference value is based on a urine PAG level obtained from the subject before the change in lifestyle,
wherein the subject is a human adult of at least 45 years of age,
wherein the ageing related chronic inflammatory disorder is atherosclerosis, arthritis, dementia, type 2 diabetes, or osteoporosis,
and

wherein an elevated urine PAG level in the sample compared to the predetermined reference value indicates an increased likelihood
that the change in lifestyle allows the subject to delay and/or avoid the ageing related chronic inflammatory disorder.

US Pat. No. 9,301,973

METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN

Nestec S.A., Vevey (CH)

1. A method for treating dermatitis in an animal comprising administering to the animal having dermatitis a therapeutically
effective amount of a combination of:
one or more antioxidants selected from the group consisting of vitamin C, polyphenols, proanthocyanidins, anthocyanins, bioflavonoids,
selenium, alpha-lipoic acid, glutathione, catechin, epicatechin, epigallocatechin, epigallocatechin gallate, epicatechin gallate,
cysteine, vitamin E, gamma tocopherol, alpha-carotene, beta-carotene, lutein, zeaxanthin, retinal, astaxanthin, cryptoxanthin,
lycopene and resveratrol, wherein the antioxidants are administered to the animal in amounts of from about 0.001 to about
1000 mg/kg/day;

one or more anti-glycation agents selected from the group consisting of carnosine, benfotiamine, pyridoxamine, alpha-lipoic
acid, phenacyldimethylthiazolium chloride, taurine, aminoguanidine, resveratrol, and aspirin, wherein the anti-glycation agents
are administered to the animal in amounts of from about 0.01 to about 1000 mg/kg/day;

one or more body fat reducing agents selected from the group consisting of conjugated linoleic acid (CLA), carnitine, acetyl-carnitine,
pyruvate, polyunsaturated fatty acids, medium chain fatty acids, medium chain triglycerides, and soy isoflavones, wherein
the body fat reducing agents are administered to the animal in amounts of from about 0.001 to about 1000 mg/kg/day; and

one or more insulin sensitivity enhancing agents selected from the group consisting of chromium, chromium picolinate, cinnamon,
cinnamon extract, polyphenols from cinnamon and witch hazel, coffee berry extract, chlorogenic acid, caffeic acid, a source
of zinc, and grape seed extract, wherein the insulin sensitivity enhancing agents are administered to the animal in amounts
of from about 0.001 to about 1000 mg/kg/day,

wherein the combination excludes anti-inflammatory agents of omega-3 fatty acids and curcumin.

US Pat. No. 9,271,600

ERGONOMIC CAPSULE EXTRACTION DEVICE

Nestec S.A., Vevey (CH)

1. A device for receiving an ingredient cartridge and extracting the ingredient by passing heated liquid through the cartridge,
the device comprising:
a cartridge seat that has an open configuration for receiving and/or removing a cartridge from such device and a closed configuration
for extracting the ingredient;

a user-movable handle for moving the cartridge seat from the open to the closed configuration and vice-versa, the user-movable
handle mounted on a fixed frame via an axis of the user-movable handle; and

the user-movable handle is associated with an end-of-stroke feed-back member for providing a corresponding feed-back to a
user actuating the handle, the feed-back member comprises a spring blade comprising an L-shaped base with a resistance ramp
and a release ramp, the spring blade further comprising a fixed end secured to the fixed frame, and a free end that is resiliently
deformable.

US Pat. No. 9,095,168

ACIDIFIED MILK BEVERAGE POWDER AND METHOD FOR PRODUCING THE SAME

Nestec S.A., Vevey (CH)

1. A powder for the preparation of an acidified milk beverage, the powder comprising:
20-40 wt % fruit juice powder;
50-70 wt % granular sugar;
1-2 wt % organic acid granules, all of the organic acid granules in the powder having a diameter from 0.4 mm to 0.7 mm;
4-10 wt % milk powder; and
3-4 wt % carboxymethylcellulose powder composed of particles, wherein the particles have a diameter of not greater than 0.1
mm.

US Pat. No. 9,392,902

CAPSULE SENSING SYSTEM

Nestec S.A., Vevey (CH)

1. A brewing unit of a beverage preparation machine, the brewing unit comprising:
a seat for holding a capsule comprising an electrically conductive material; and
a capsule sensing electric circuit with first and second electric connectors, the first electric connector and the second
electric connector are:

electrically connected through the electrically conductive material of the capsule when the capsule is present in the seat,
at least one of the electric connectors is arranged to contact a capsule surface made of the electrically conductive material
of the capsule when the capsule is present in the seat and to circulate an electric current therethrough; and

electrically disconnected when the capsule is not in the seat and/or when the seat is in an open configuration for receiving
and/or evacuating a capsule, so as to close and interrupt, respectively, the capsule sensing electric circuit.

US Pat. No. 9,510,707

VIBRATION PROOF WATER TANK OF A BEVERAGE MACHINE

Nestec S.A., Vevey (CH)

1. A beverage preparation machine comprising:
a beverage preparation module that vibrates during use; and
a reservoir for storing liquid and supplying the liquid to the beverage preparation module,
the beverage preparation module and the reservoir are connected by a vibration-barrier mechanical connection comprising (i)
a resilient section and (ii) a counter-plug mounted in the resilient section, the resilient section configured for inhibiting
or preventing propagation of vibrations from the beverage preparation module to the reservoir, and the reservoir having a
foot that rests during use on an external support, the external support is unsecured to the beverage preparation module,

the vibration-barrier mechanical connection has a fluid circulation line extending from the beverage preparation module to
the reservoir and comprising the resilient section,

the beverage preparation module has a fluid connector with a liquid inlet, and the reservoir has a fluid connector with a
liquid outlet, the fluid connector of the beverage preparation module and the fluid connector of the reservoir being connectable
to bring the reservoir in fluid communication with the beverage preparation module,

the fluid connector of the beverage preparation module forms a docking station for the reservoir, the liquid outlet of the
reservoir comprises a plug comprising a seal urged against peripheral walls of the liquid outlet by a spring to block the
liquid outlet, and mounting of the reservoir on the docking station comprises the counter-plug forcing the plug upwardly to
space the seal from the peripheral walls to form a passage for liquid to flow from a bottom part of the reservoir through
the liquid outlet into the liquid inlet.

US Pat. No. 9,320,385

BARCODE FOR A BEVERAGE PREPARATION CAPSULE

Nestec S.A., Vevey (CH)

1. A beverage preparation system comprising:
a capsule with side, bottom and top walls, the capsule having a shape that is substantially symmetrical around a vertical
axis, the capsule is a rigid capsule comprising a frustoconical body with side and bottom walls, the body closed at the top
with a circular membrane forming the top side, and the capsule is suitable for containing a beverage preparation ingredient
to be dissolved, and/or infused, and/or extracted under pressure, by action of a fluid circulating into the capsule through
the ingredient;

a beverage preparation machine suitable for receiving the capsule and circulating the fluid into the capsule;
the machine comprises a linear barcode reader suitable for reading a linear barcode sequence contained in a segment having
a segment length LR, the linear barcode reader being positioned in the machine such that the linear barcode reader can read a barcode printed
on the capsule while the capsule is being inserted inside the machine;

the capsule comprises a barcode sequence that is repeatedly printed along a peripheral path of the capsule, each sequence
being disposed in an arc having a linear projected length LS, the linear projected length LS is less than the length LR for which the linear barcode reader is suitable, and the sequence is composed of dots spaced apart from one another along
the arc such that their projected point images along a linear segment are also spaced apart; and

the linear bar code reader is positioned inside the machine such that during insertion of the capsule into the machine, the
center Cra of the reading area is aligned with the center Ctm of the circular membrane forming the top side of the capsule, and the direction of insertion is substantially perpendicular
to the transversal axis of the reading area.

US Pat. No. 9,950,149

BIOMOLECULAR CELL ENCAPSULATION DEVICE AND METHODS OF IMPLANTATION

NESTEC S.A., (CH) ECOLE ...

1. A biomolecular encapsulation device comprising an internal chamber suitable for holding living cells, wherein the internal chamber is disposed between an inner surface of a first semi-permeable layer and an inner surface of a second semi-permeable layer, and the first and second semi-permeable layers are mounted on a supporting frame surrounding a perimeter of the internal chamber; wherein the supporting frame comprises a first frame element that is interconnected to a second frame element, and the first and second frame elements co-operate to position the first and second semi-permeable layers at a predetermined separation distance between the layerswherein the first frame element comprises (a) a first mounting region to which an outer surface of the first semi-permeable layer is attached and (b) a first spacer region that is unitary with the first mounting region, and
wherein the second frame element comprises (a) a second mounting region to which an outer surface of the second semi-permeable layer is attached and (b) a second spacer region that is unitary with the second mounting region,
such that when the first and second frame elements interconnect the first and second spacer regions are positioned between the first and second mounting regions and together define the predetermined separation distance between the layers.

US Pat. No. 9,500,660

ISOVALERYLGLYCINE AS BIOMARKER FOR THE PREDISPOSITON FOR WEIGHT GAIN AND OBESITY

Nestec S.A., (CH)

1. A method of diagnosing the likelihood of a subject to resist high fat diet induced weight gain, the method comprising:
obtaining a urine sample from a subject provided with a high fat diet,
determining the level of isovalerylglycine in the urine sample using 1H-NMR spectroscopy,

comparing the subject's isovalerylglycine level to a predetermined reference value, by mapping of a urinary excretion pattern
of the isovalerylglycine, and

providing a subject determined to be at risk for high fat diet induced weight gain with diet and lifestyle treatment options,
wherein the predetermined reference value is based on an average isovalerylglycine level in urine in a control population,
an increased isovalerylglycine level in the sample compared to the predetermined reference value indicates an increased likelihood
to resist high fat diet induced weight gain, and

the increased isovalerylglycine level is determined relative to a cut-off value of the average isovalerylglycine level in
the control population.

US Pat. No. 9,233,090

CYSTEINE AND FOOD INTAKE

Nestec S.A., Vevey (CH)

1. A method for the treatment of malnutrition and/or a disorder related thereto in an elderly subject in need thereof, the
method comprising administering to the elderly subject a nutritional composition that contains from about 20 to 70% of the
calories of the nutritional composition from carbohydrates, and a protein fraction comprising at least 5 weight-% cysteine
to increase food intake and/or decrease satiety and/or satiation.
US Pat. No. 9,370,538

NON-REPLICATING PROBIOTIC MICRO-ORGANISMS PROTECT AGAINST UPPER RESPIRATORY TRACT INFECTIONS

Nestec S.A., Vevey (CH)

1. A method for treatment of rhinitis and/or its symptoms, the method comprising:
administering to an individual in need of same a composition comprising non-replicating probiotic micro-organisms that have
been rendered non-replicating by a heat-treatment at 120-140° C. for about 1-120 seconds, the non-replicating probiotic micro-organisms
selected from the group consisting of Bifidobacterium longum BB536 (ATCC BAA-999), Bifidobacterium longum NCC 2705 (CNCM I-2618), Bifidobacterium breve NCC 2950 (CNCM I-3865), Bifidobacterium lactis NCC 2818 (CNCM I-3446), Lactobacillus paracasei NCC 2461 (CNCM I-2116), Lactobacillus rhamnosus NCC 4007 (CGMCC 1.3724), Lactobacillus casei CTP31 (NCC 4006), Lactobacillus acidophilus NCC 3009 (ATCC 700396), Lactobacillus casei ACA-DC 6002 (NCC 1825), Escherichia coli Nissle (DSM 6601), Lactobacillus bulgaricus NCC15, Lactobacillus lactis NCC 2287, S. thermophilus NCC2019, and combinations thereof.

US Pat. No. 9,943,559

NUTRITIONAL COMPOSITIONS FOR REDUCING INTESTINAL PATHOGENS

Nestec S.A., Vevey (CH)

1. A method comprising the steps of:administering to a patient that has received an antibiotic treatment and has a C. difficile infection, a therapeutically effective amount of a fiber blend comprising fructo-oligosaccharides (FOS), acacia gum and inulin to treat the C. difficile infection, after the antibiotic treatment.
US Pat. No. 9,687,456

NUTRITIONAL COMPOSITIONS FOR MODULATING INFLAMMATION INCLUDING EXOGENOUS VITAMIN K2

Nestec S.A., Vevey (CH)

1. A method of modulating the effects of inflammation, the method comprising administering a nutritional composition comprising
an effective amount of exogenous MK-7 to a patient having cystic fibrosis.
US Pat. No. 9,498,502

PREVENTION AND TREATMENT OF ALLERGIC DIARRHEA

Nestec S.A., Vevey (CH)

10. A method for treating allergic diarrhoea comprising orally administering a composition comprising between 103 and 1012 cfu of Bifidobacterium breve CNCM I-3865 (NCC2950) per g of the composition to an individual having the allergic diarrhoea.
US Pat. No. 9,480,670

REDUCTION OF RISK OF OBESITY

Nestec S.A., Vevey (CH)

1. A nutritional composition for a mammal, the nutritional composition comprising:
a protein source that is less than 1.85 g/100 kcal of the nutritional composition;
a lipid source in an amount of 4.4 to 6 g/100 kcal of the nutritional composition, the lipid source comprising linoleic acid
(LA) and ?-linolenic acid (ALA) in a ratio of LA:ALA less than 7:1;

a carbohydrate source; and
arachidonic acid (ARA) in an amount from 1.5% to 2% of total fatty acid content of the nutritional composition, and the nutritional
composition not containing docosahexaenoic acid.

US Pat. No. 9,237,823

BEVERAGE PRODUCTION SYSTEM USING CAPSULES

Nestec S.A., Vevey (CH)

1. A beverage production system comprising:
a capsule; and
a module for producing a beverage from the capsule:
the capsule comprising an enclosure and a rim, and
the module comprising:
a first capsule engagement member, which can be displaced relative to a second, co-operating capsule engagement member between
a capsule discharge position, in which the capsule is discharged from the first capsule engagement member, and a beverage
production position,

a retractor for actively retracting the first capsule engagement member from the beverage production position to the capsule
discharge position which is offset relative to a beverage flow path,

the displaceable first capsule engagement member comprising a member having the shape of a hollow bell,
the capsule having an enclosure outer shape that conforms to at least a portion of the hollow bell shaped member and the capsule
having a rim size such that at least a part of the rim of the capsule extends beyond at least a part of the first capsule
engagement member once it is engaged in the first capsule engagement member,

the displaceable first capsule engagement member comprises discrete bumps placed on an internal surface of the hollow bell
member to create a friction with a discrete part of the outer shape of the enclosure of the capsule, and

the module comprises an engagement for the rim of the capsule extending beyond the first capsule engagement member when the
first capsule engagement member is displaced from the beverage production position to the capsule discharge position.

US Pat. No. 9,232,874

BEVERAGE PREPARATION MACHINE

Nestec S.A., Vevey (CH)

1. A beverage preparation machine comprising:
a tank for containing a food-grade fluid, the tank comprising: a reservoir body with side, bottom and top walls, at least
one dispensing opening comprising a spring-mounted poppet valve for establishing a fluid connection between the machine and
the tank, the spring-mounted poppet valve comprising a stem head, a valve stem resting onto a surface of the machine, and
a spring that is in contact at one end with the valve stem and on the other end with the reservoir, the tank having a weight
WE when less than 5% of its total volume is filled, and a weight WF when at least 5% of its total volume is filled with fluid, the valve being reciprocally movable between a first position where
the tank has a weight WE and the valve is closed by the spring pushing the reservoir body into contact with the stem head, and a second position where
the tank has a weight WF and the valve is opened by the reservoir body compressing the spring and moving out of contact with the stem head;

a switch located in the vicinity of at least one wall of the tank, so that: when the tank has a weight WF the tank is in a first position so that the tank wall contacts the switch, and when the tank has a weight WE the tank is in a second position, away from the switch; and

a user warning device that is actuated when the switch does not contact the tank wall so as to warn the user that the tank
needs a refill.

US Pat. No. 9,499,333

CAPSULE, BEVERAGE PRODUCTION MACHINE AND SYSTEM FOR THE PREPARATION OF A NUTRITIONAL PRODUCT

Nestec S.A., Vevey (CH)

1. A capsule for containing nutritional ingredients and designed for insertion in a beverage production machine, the capsule
comprising:
a cup-shaped base body having a bottom, a side wall and an inlet face, the inlet face of the cup-shaped base body presents
a contour, which is not symmetric in circumference, and presents a bulge section extending from an essentially circular section;

a filter unit positioned in a seat of the cup-shaped base body below the bulge section of the inlet face; and
an optically readable code is provided on the side wall at a position which, when viewing the capsule from the inlet face,
is located opposite the bulge section.

US Pat. No. 9,345,728

NON-REPLICATING PROBIOTIC MICRO-ORGANISMS PROTECT CHILDREN AGAINST GASTROINTESTINAL INFECTIONS

Nestec S.A., Vevey (CH)

1. A method for treatment of gastrointestinal infections in children comprising administering to a child in need of same a
therapeutically-effective amount of a composition comprising non-replicating probiotic micro-organisms that have been rendered
non-replicating by a heat treatment at a temperature of 120° C. to 140° C. for 5-15 seconds, wherein the probiotic micro-organisms
are selected from the group consisting of Bifidobacteria, Lactobacilli, Propionibacteria, and combinations thereof, and the
composition is administered in an amount to provide about 0.005 mg-1000 mg of the non-replicating micro-organisms to the child
per day.

US Pat. No. 9,683,978

SYSTEMS AND METHODS FOR DETECTING WATER/PRODUCT INTERFACES DURING FOOD PROCESSING

Nestec S.A., Vevey (CH)

1. A method for detecting a water/food product interface in an aseptic manufacturing system, the method comprising:
initiating flow in a conduit in an aseptic food manufacturing system;
operating an ultrasonic flow detection device transmitting an ultrasonic beam through a wall of the conduit, wherein the ultrasonic
beam is refracted at angles from the wall of the conduit and reflected from particles present in the conduit at a range of
angles and frequencies, and measuring returned reflected signals; and

analyzing the measured returned reflected signals to determine a change in particle concentration indicating a water/food
product interface.

US Pat. No. 9,592,953

POD AND PACKAGE FOR PREPARING A BEVERAGE BY CENTRIFUGATION

Nestec S.A., Vevey (CH)

1. A pod for the preparation of a beverage in a centrifugal brewing device by feeding liquid through the pod and rotating
the pod along a rotating axis in the device to produce centrifugal forces on the liquid traversing the pod thereby forcing
a beverage out of the pod by such centrifugal forces, wherein the pod comprises containment walls containing beverage ingredients,
the containment walls being essentially made of porous filtering material and comprising a top wall from which a central funnel
comprising liquid inlet openings extends inwardly in the pod, wherein the porous filtering material has an elongation at break
which is at least 250%.

US Pat. No. 9,451,845

BREWING CHAMBER FOR A BEVERAGE PRODUCTION DEVICE

Nestec S.A., Vevey (CH)

1. A brewing or preparation chamber of a beverage preparation device, which is suitable for receiving and extracting a portion
capsule filled with powdered or liquid base beverage materials and which comprises, completely or partly, of electrically
conductive material, and the brewing or preparation chamber comprises: a stationary first chamber part, which is provided
with an opener for opening the portion capsule for the outlet of the beverage and is connected in a fluid-conducting manner
to a structure for the beverage to flow out, and a second chamber part which can be moved horizontally or vertically with
respect to the first chamber part, is connected in a fluid-conducting manner to an assembly which feeds in the extraction
liquid in order to supply the portion capsule with the extraction liquid and is provided with at least two piercing members
for opening the portion capsule and for introducing the extraction liquid into the portion capsule, the brewing or preparation
chamber being opened to receive a portion capsule and closed to extract the portion capsule; and
in each case at least two electrically conductive contacts electrically insulated with respect to each other and with respect
to the chamber parts are arranged in the first chamber part and in the second chamber part, and when there is a portion capsule
lying in the closed brewing or preparation chamber, the electrically conductive contacts of the first chamber part are in
electrically conductive contact with the electrically conductive capsule closing foil, and the electrically conductive contacts
of the second chamber part (4) are in electrically conductive contact with the electrically conductive capsule body or electrically conductive zones of
the capsule body, and an input contact of the first chamber part is electrically conductively connected to the test voltage
output of a control device, and an output contact of the first chamber part is conductively connected to an input contact
of the second chamber part, and an output contact of the second chamber part is conductively connected to the test voltage
input of the control device, and the test current loop is made by the electrically conductive closing foil and the electrically
conductive capsule body or the electrically conductive zones of the latter.

US Pat. No. 9,386,876

DEVICE FOR ADAPTING A FOOD CAPSULE INTO A CAPSULE HOLDER

Nestec S.A., Vevey (CH)

1. A food preparation machine for preparing a food product, the food preparation machine adapted to receive a capsule or pod
holder configured to directly receive and hold at least one capsule or pod of a first kind, the food preparation machine comprising:
a fluid injection element movable relative to the capsule or pod holder, for circulating a fluid through an internal chamber
of the at least one capsule or pod of the first kind, to a discharge opening of the at least one capsule or pod of the first
kind;

at least one adapting device for adapting at least one capsule or pod of a second kind into the capsule or pod holder, the
at least one capsule or pod of the second kind being smaller than the at least one capsule or pod of the first kind, the at
least one adapting device comprising:

a holding portion for holding at least a portion of the at least one capsule or pod of the second kind, wherein the holding
portion contacts and holds the entire surface of side walls of the at least one capsule or pod side of the second kind, at
least at the time the fluid circulates through the at least one capsule or pod of the second kind,

a sealer for circumferentially adapting to at least one member selected from the group consisting of (i) the capsule or pod
holder, (ii) the fluid injection element and (iii) a capsule outside surface, in a leak-tight manner so that the fluid is
directed solely from the fluid injection element through an internal chamber of the at least one capsule or pod of the second
kind, to a discharge opening of the at least one capsule or pod of the second kind, the sealer extending below a top surface
of the capsule or pod holder between the capsule or pod holder and the capsule outside surface,

a ring-like device body, an external shape and size of the ring-like device body adapted to fit at least partially an internal
shape and size of the capsule or pod holder, and the internal shape and size of the capsule or pod holder adapted to fit at
least partially an external surface of the at least one capsule or pod of the second kind; and

a closing lid for closing the ring-like device body, the closing lid comprising an opening positioned relative to the fluid
injection element to allow the fluid through the closing lid into the at least one capsule or pod of the second kind.

US Pat. No. 9,255,819

DEVICE FOR SENSING A CAPSULE IN A BEVERAGE PRODUCTION APPARATUS

Nestec S.A., Vevey (CH)

1. A device for sensing a capsule containing a beverage ingredient in a beverage production apparatus, the device comprising:
a receptacle configured to receive the capsule;
a sensing member configured to sense the presence of different sizes of capsules in the receptacle, the sensing member comprises
a movable component configured to move between positions that correspond to the different sizes of the capsule, and the movable
component is positioned at least partially within the receptacle in at least one of the positions; and

a coding member at least partially located on the movable component, and configured to detect a position of the movable component
and provide different codes based on the position of the movable component, the different codes each correspond to one of
the different sizes of capsules sensed by the sensing member.

US Pat. No. 10,086,072

METHODS OF DISEASE ACTIVITY PROFILING FOR PERSONALIZED THERAPY MANAGEMENT

Nestec S.A., Vevey (CH)

1. A method for monitoring therapeutic efficiency in an individual receiving therapy having inflammatory bowel disease (IBD), wherein the IBD comprises Crohn's disease, the method comprising:(a) measuring the levels of an array of mucosal healing markers in a sample from the individual at a plurality of time points over the course of therapy;
(b) applying a statistical algorithm to the level of the one or more markers determined in step (a) to generate a mucosal healing index;
(c) comparing the individual's mucosal healing index to that of a control, wherein the control is an endoscopic score;
(d) determining whether the therapy is appropriate for the individual to promote mucosal healing; and
(e) administering an appropriate therapy.
US Pat. No. 9,492,416

USE OF CAFTARIC ACID AND LACTIC BACTERIUM IN FOOD SUPPLEMENT FOR REGULATING SKIN PIGMENTATION

Nestec S.A., Vevey (CH)

1. A method for treating skin pigment disorders and/or skin pigment imperfections in an individual in need thereof, said disorders
and imperfections being associated with hyperpigmentation, comprising administering orally a food supplement comprising at
least (i) a daily dose of 0.01 g-100 g of an ingredient containing an amount of 0.1-50 weight % of dry weight of caftaric
acid and/or derivatives thereof, and (ii) an amount of 0.1-50 weight % of dry weight, as compared to the dry weight of the
food supplement, of a lactic acid bacterium and/or an enzyme capable of hydrolyzing caftaric acid to generate, during digestion,
tartaric and/or caffeic acid, said individual in need thereof having a disorder and/or imperfection associated with hyperpigmentation,
and said lactic acid bacterium and/or enzyme capable of hydrolyzing caftaric acid being administered in an adapted amount
for sufficient hydrolysis of the caftaric acid.

US Pat. No. 9,452,866

CUP SUPPORT AND DISPENSING DEVICE

Nestec S.A., Vevey (CH)

1. A cup support for holding a cup in a dispensing device, the cup support comprising:
a base;
at least one outer support structure on an outer periphery of the base;
at least one inner support structure arranged on a first surface of the base within the outer periphery of the base; and
the at least one cup holding space is formed between an inner sidewall of the at least one outer support structure and an
outer sidewall of the at least one inner support structure,

wherein the at least one inner support structure is at least one fin-shaped element with a leading edge as the outer sidewall
of the at least one fin-shaped elements, and a tail of the at least one fin-shaped element curves downward to a center of
the base.

US Pat. No. 9,415,913

COATED CONTAINER

Nestec S.A., Vevey (CH)

1. A polyolefin container coated with a gas barrier coating comprising a first layer of hydrogenated amorphous silicon nitride
and a second layer of hydrogenated amorphous carbon, the hydrogenated amorphous silicon nitride layer being deposited on the
container, and the hydrogenated amorphous carbon layer being deposited on the hydrogenated amorphous silicon nitride layer.

US Pat. No. 9,399,546

CAPSULE AND METHOD FOR THE PREPARATION OF A BEVERAGE BY CENTRIFUGATION

Nestec S.A., Vevey (CH)

1. A method for preparing a beverage in a centrifugal brewing device using a capsule, the method comprising:
feeding a liquid in a compartment of the capsule,
rotating the capsule along a central axis of the capsule to produce centrifugal forces on the liquid traversing the capsule
thereby forcing the beverage out of the capsule by the centrifugal forces; and

perforating a transversal closing wall of the capsule by applying a pressure on the transversal closing wall and/or a perforating
wall, the capsule comprises the perforating wall, and the perforating wall comprises a perforating element configured to perforate
the transversal closing wall when the pressure is applied on the transversal closing wall and/or the perforating wall.

US Pat. No. 9,201,081

PC-O 44:6—A BIOMARKER FOR VISCERAL ADIPOSITY

NESTEC S.A., Vevey (CH)

1. A method of diagnosing the effect of a change in lifestyle on visceral adiposity in a subject, comprising:
determining a level of 1-0-alkyl-2-acylglycerophosphocholine (PC-O) 44:6 in a body fluid sample obtained from a subject after
a change in lifestyle, and

comparing the subject's PC-O 44:6 level to a predetermined reference value,
wherein the predetermined reference value is based on a PC-O 44:6 level in the same body fluid obtained from the same subject
before the change in lifestyle, and

wherein an increased PC-O 44:6 level in the sample compared to the predetermined reference value indicates a positive effect
of the change in lifestyle on visceral adiposity.

US Pat. No. 9,101,245

BEVERAGE DISPENSER WITH IMPROVED OUTLET TUBES ASSEMBLY

Nestec S.A., Vevey (CH)

1. Beverage dispenser comprising:
at least one beverage ingredient processing assembly presenting one outlet for evacuating a beverage;
at least one conduit removably connected to the outlet of the at least one beverage ingredient processing assembly for dispensing
the beverage in a container;

the dispenser comprises a drawer assembly comprising a drawer comprising an upper part and a lower part, both parts being
at least partly removable one from the other, at least one of the parts presenting at least one groove on its internal surface
so that when the two parts are connected together the at least one groove forms at least a part of the least one conduit for
dispensing the beverage from the beverage ingredient processing assembly outlet to the container;

the upper part and the lower part of the drawer assembly are made of a first hard material; and
a second soft polymer material covers a part of the internal surface of the upper and/or the lower part so that when the two
parts are connected and squeezed together the part of the least one conduit formed by the at least one groove is liquid and
air tight; and

the drawer assembly comprises a cover for maintaining and squeezing the upper part and the lower part one against the other.

US Pat. No. 9,060,646

MILK FROTHING WITH PRESSURIZED GAS

Nestec S.A., Vevey (CH)

1. A milk frothing device comprising:
a milk reservoir;
a supply of pressurized gas;
a mixing area for mixing milk from the milk reservoir and gas;
an injection gas conduit in fluid communication with the mixing area for injecting gas into milk in the mixing area;
a milk conduit that is tubular and extends from an interior of the milk reservoir to an exterior of the milk reservoir, the
mixing area located inside the milk conduit;

a pressurized gas supply arrangement for driving milk from the milk reservoir to the mixing area,
the pressurized gas supply arrangement has a propelling gas conduit that extends into the interior of the milk reservoir and
is configured to deliver pressurized propelling gas therein to pressurize the reservoir and propel pressurized milk from the
reservoir to the mixing area; and

an in-line heater so constructed and arranged as to heat in-line only the pressurized milk propelled to the mixing area, with
the remaining milk in the milk reservoir being unheated by the in-line heater.

US Pat. No. 9,980,950

MATERNAL VITAMIN B6 ADMINISTRATION FOR THE PREVENTION OF INCREASED ADIPOSITY, OVERWEIGHT OR OBESITY IN THE OFFSPRING

Nestec S.A., Vevey (CH)

1. A method of reducing the likelihood of developing obesity, excessive fat accumulation and/or metabolic disorders associated with either of the foregoing in the offspring of a mother having a vitamin B6 serum level of <20 nmol/L, the method comprising administering a composition in a daily dose comprising Vitamin B6 in an amount of 2.5-60 mg Vitamin B6/day to the mother before pregnancy, during pregnancy and/or during lactation to provide a vitamin B6 serum level of ?20 nmol/L.

US Pat. No. 9,811,704

SUPPORT AND CAPSULE FOR PREPARING A BEVERAGE BY CENTRIFUGATION, SYSTEM AND METHOD FOR PREPARING A BEVERAGE BY CENTRIFUGATION

Nestec S.A., Vevey (CH)

1. A code support to be associated with or part of a capsule intended for delivering a beverage in a beverage producing device
by centrifugation of the capsule, the support comprising:
a code formed by at least a first sequence of symbols, said code being represented on the support so that each symbol is sequentially
readable by a reading arrangement of an external reading device while the capsule is driven in rotation about an axis of rotation,
the first sequence comprising at least one first data sequence formed by at least two sub-sequences of symbols, each one of
said at least two sub-sequences further comprising at least one error-checking symbol for allowing a validity check of the
symbols of said sub-sequence;

at least a second sequence of symbols, the second sequence comprising at least one second data sequence identical to the first
data sequence of the first sequence; and

wherein each sequence further comprises at least one preamble sequence of symbols, and wherein the first sequence and at least
one other sequence have distinct preamble sequences.

US Pat. No. 9,688,425

PREFORM AND CONTAINER COMPRISING REINFORCING ELEMENTS

Nestec S.A., Vevey (CH)

1. A preform for a container, the preform comprising:
at least three reinforcing elements, each having a substantially triangular cross-section and provided on an inner side of
a side wall of the preform extending each at a step in a direction perpendicular to a longitudinal axis of the preform and
equidistant to each adjacent reinforcing element, wherein at each step, the inner side of the side wall is bent inward at
an angle of about 90° relative to a longitudinal axis of the preform while a diameter of an outer side of the side wall decreases
gradually, and the at least three reinforcing elements each have a thickness which is 7% to 50% greater than a thickness of
the side wall of the preform.

US Pat. No. 9,504,265

FILLING COMPOSITION COMPRISING AN ENCAPSULATED OIL

Nestec S.A., Vevey (CH)

1. A filling composition consisting of:
from 5 to 60% w/w of an oil powder, the oil powder comprising at least 60% w/w of a liquid oil in an inner core, encapsulated
in an outer shell of a matrix material comprising protein;

from 1 to 20% w/w of a free liquid oil;
a solid fat, wherein a combination of the oil powder and the free liquid oil is 15-75% of a total of the oil powder, the free
liquid oil, and the solid fat;

from 10 to 70% w/w of sugar;
from 5 to 70% w/w of cocoa powder; and
at least one supplementary ingredient selected from the group consisting of skimmed milk powder, full cream milk powder, whey
powder, fruit acids, natural flavors, synthetic flavors, natural colors, artificial colors, and emulsifiers.

US Pat. No. 9,506,099

NATURAL TASTE ENHANCING SAVOURY BASE AND A PROCESS FOR ITS PREPARATION

Nestec S.A., Vevey (CH)

1. A process for the preparation of a taste enhancing savory base comprising between 0.01 and 80% of naturally derived compounds
selected from the group consisting of glutamate, IMP and GMP, amino acids in which alanine, aspartic acid, glutamine, glutamic
acid, glycine, leucine, lysine, methionine, tryptophan and valine are a majority of the amino acids, and naturally food derived
compounds selected from the group consisting of trimethylpyrazine, propionic acid, and combinations thereof, the process comprising:
producing a first product by fermenting a first substrate using a microorganism of Corynebacterium for 20 to 48 hours, at a pH between 5 and 9 and at a temperature between 25 and 40° C.;

producing a second product by fermenting a second substrate using a microorganism of Corynebacterium for 3 to 6 days, at a pH between 5 and 9 and at a temperature between 25 and 40° C.; and

mixing the first product with the second product.

US Pat. No. 9,458,039

PRODUCTION PROCESS FOR A ZINC ENRICHED DRINKING WATER, COMPOSITION AND PACKAGED WATER

Nestec S.A., Vevey (CH)

1. A method for producing a zinc enriched drinking water which, starting from a water matrix comprising drinking water, the
method comprising:
measuring the pH of the water matrix,
and then;
acidifying the water matrix in order to get a final water product having a pH between 6.5 and 7; and
adding zinc in a concentration comprised between 0.8 mg/l and 5 mg/l,
so that sedimentation of zinc in the final water product is less than 10% of soluble zinc over a period of 12 months at a
maximum temperature of 40° C.

US Pat. No. 9,434,527

SYSTEMS AND METHODS FOR MANUFACTURING MULTI-COMPARTMENT PRODUCTS CONTAINING WET AND DRY COMPONENTS

Nestec S.A., Vevey (CH)

1. A manufacturing system for producing a package having a wet food component and a dry food component wherein each of the
wet food component and the dry food component is free of any artificial preservatives, comprising:
a one piece tray comprising a top surface and at least a first compartment and a second compartment separate from each other;
and

a continuous manufacturing line including a dry food packaging area having a first conveyor, a wet food packaging area having
a second conveyor, a transfer conveyer separate from and in communication with the first conveyor and the second conveyor,
and a barrier separating the dry food packaging area from the wet food packaging area, the tray being passable through the
barrier via the transfer conveyor in a way that prevents contact between the first conveyor and the second conveyor and prevents
cross-contamination between the dry food packaging area and the wet food packaging area,

wherein the dry food packaging area comprises a dry food filling apparatus containing a dry food component free of any artificial
preservatives arranged to fill the first compartment of the tray with the dry food component, and an evacuation apparatus
to evacuate any dry food component from the second compartment of the tray,

wherein the wet food packaging area comprises a wet food filling apparatus containing a wet food component free of any artificial
preservatives arranged to fill the second compartment of the tray with the wet food component, and a sealing apparatus to
secure a single lid to the top surface of the tray to seal the first compartment and the second compartment in a way to prevent
cross-contamination between the dry food component and the wet food component,

wherein neither the wet food component nor the dry food component is pre-packaged.
US Pat. No. 9,410,138

ASPARAGINASE FROM BASIDIOMYCETES

Nestec S.A., Vevey (CH)

1. A method for hydrolyzing at least one of L-asparagine or L-glutamine, the method comprising:
treating a substance comprising at least one of L-asparagine or L-glutamine with an asparaginase enzyme comprising the amino
acid sequence of SEQ ID NO: 1, thereby hydrolyzing said at least one of L-asparagine or L-glutamine; and

inactivating said asparaginase enzyme by thermal treatment of said substance.

US Pat. No. 9,346,599

FOOD PACKAGING

Nestec S.A., Vevey (CH)

1. A food packaging comprising:
a base tray with walls terminating in a protuberance land, the protuberance land having an upper surface comprising a protuberance
indent at least partially surrounded by an indent wall, the indent wall extending continuously along an inward side of the
protuberance indent to separate the protuberance indent from a main cavity formed by the base tray walls, and the base tray
comprising (1) an inwardly directed protuberance comprising a protuberance upper surface comprising the protuberance indent
and (2) a corner land comprising a corner land upper surface comprising a corner indent at least partially surrounded by a
corner indent wall, the corner indent wall extending continuously along an inward side of the corner indent to separate the
corner indent from the main cavity formed by the base tray walls; and

a second tray nested in the base tray and comprising a first flange supported by the protuberance land and a second flange
portion supported by the corner land, the first flange extending partially over the protuberance indent, the protuberance
indent sized to admit a finger within the protuberance indent below the first flange, the protuberance is located at a base
tray side wall, the second tray abutting the inwardly directed protuberance and a base tray end wall such that the second
tray is located by the inwardly directed protuberance and the base tray end wall, and the second flange portion configured
to extend partially over the corner indent when the second tray is fully seated in the base tray such that the corner indent
is accessible to admit a finger when the second tray is fully seated in the base tray.

US Pat. No. 9,277,839

SECURE CUP SUPPORT FOR BEVERAGE MACHINE

Nestec S.A., Vevey (CH)

1. A machine for dispensing a beverage comprising:
an outlet for dispensing the beverage;
a first user-recipient support movable within the machine from a position for supporting a smaller user-recipient under the
outlet to a position for placing a larger user-recipient under the outlet, the first user-recipient support being pivotable
about a vertical axis within such machine from the smaller user-recipient position to the larger user-recipient position;

a second user-recipient support positioned below the first user-recipient support;
a member for stopping movement of the first user-recipient support in at least one of the positions; and
the stopping member comprises a fastener for fastening the first user-recipient support in the at least one of the positions,
the fastener being positioned on at least one connector extending between the first and second user-recipient supports and
arranged to automatically fasten the first user-recipient support when the first user-recipient support reaches the at least
one of the positions.

US Pat. No. 9,242,791

CAPSULE FOR PREPARING AND DELIVERING A DRINK BY INJECTING A PRESSURIZED FLUID INTO THE CAPSULE

Nestec S.A., Vevey (CH)

1. A capsule for delivering a drink by injecting a pressurized fluid into the capsule comprising:
a hollow body and an injection wall attached to the body;
an injection space allowing an injection means in the form of at least one jet of pressurized fluid to be introduced through
the injection wall;

a chamber defined by the body and containing a bed of at least one food substance to be extracted;
means for retaining an internal pressure in the chamber; and
means for impacting the jet of fluid so as to reduce a speed of the jet of fluid injected into the capsule and distribute
the fluid across the bed of substance at a reduced speed, wherein the means for impacting the jet of fluid comprises (i) at
least one wall that separates the injection space from the chamber, and (ii) a multitude of openings passing through the wall
in such a way as to distribute the flow of fluid across the bed of substance.

US Pat. No. 9,161,563

OLIGOSACCHARIDE MIXTURE AND FOOD PRODUCT COMPRISING THIS MIXTURE, ESPECIALLY INFANT FORMULA

Nestec S.A., Vevey (CH)

1. A food product comprising: hydrolyzed proteins; and an oligosaccharide mixture which comprises:
5-70 wt % of at least one N-acetylated oligosaccharide selected from the group consisting of N-acetyl-galactosaminyl-lactose
and galactosyl-N-acetyl-galactosaminyl-lactose,

5-90 wt % of at least one galacto-oligosaccharide selected from the group consisting of Gal?1,6Gal, Gal?1,6Gal?1,4Glc, Gal?1,6Gal?1,6Glc,
Gal?1,3Gal?1,3Glc, Gal?1,3Gal?1,4Glc, Gal?1,6Gal?1,6Gal?1,4Glc, Gal?1,6Gal?1,3Gal?1,4Glc, Gal?1,3Gal?1,6Gal?1,4Glc, Gal?1,3Gal?1,3Gal?1,4Glc,
Gal?1,4Gal?1,4Glc and Gal?1,4Gal?1,4Gal?1,4Glc,

2-50 wt % of at least one sialylated oligosaccharide selected from the group consisting of 3?-sialyllactose and 6?-sialyllactose;
and

2-70 wt % of at least one fucosylated oligosaccharide selected from the group consisting of 2?-fucosyllactose, 3-fucosyllactose,
difucosyllactose, lacto-N-fucopentaoses, lacto-N-difucohexaose I, monofucosyllacto-N-hexaose, Difucosyllacto-N-hexaose I and
Difucosyllacto-N-neohexaose II.

US Pat. No. 9,101,651

LACTOBACILLUS RHAMNOSUS AND WEIGHT CONTROL

Nestec S.A., Vevey (CH)

1. A composition that supports weight management, promotes weight loss and/or treats obesity comprising Lactobacillus rhamnosus CGMCC 1.3724 in an amount from 107 to 1012 cfu per g of dry weight of the composition, a protein source, a fat source that provides 5% to 40% of a total energy of the
composition, and a carbohydrate source that provides 40% to 80% of the total energy of the composition.

US Pat. No. 9,049,751

HIGHLY CONDUCTIVE MICROWAVE SUSCEPTORS

Nestec S.A., Vevey (CH)

1. A microwaveable package comprising:
a container defining an interior and comprising a microwave shielding material surrounding the interior, wherein at least
a portion of the microwave shielding material is a conductive susceptor comprising an electrical resistance that is below
about 100 ?, and the conductive susceptor comprises a standard microwave susceptor layer and a shielding layer comprising
a substrate including a source of mobile charges, wherein the shielding layer is at least substantially metal free.

US Pat. No. 9,868,588

OPTICAL READABLE CODE SUPPORT AND CAPSULE FOR PREPARING A BEVERAGE HAVING SUCH CODE SUPPORT PROVIDING AN ENHANCED READABLE OPTICAL SIGNAL

Nestec S.A., Vevey (CH)

1. An optically readable code support to be associated with or be part of a capsule intended for delivering a beverage in
a beverage producing device, the optically readable code support comprising at least one sequence of symbols represented on
the optically readable code support so that each symbol of the at least one sequence of symbols is sequentially readable by
a reading arrangement of an external reading device while the capsule is driven in rotation along an axis of rotation, wherein
the at least one sequence of symbols are essentially formed of light reflective surfaces and light absorbing surfaces comprising
a base structure extending continuously at least along the at least one sequence of symbols and discontinuous discrete light-absorbing
portions locally applied onto or formed at a surface of the base structure, the discontinuous discrete light-absorbing portions
form the light-absorbing surfaces and the base structure forms the light-reflective surfaces outside surface areas occupied
by the discontinuous discrete light-absorbing portions, the discontinuous discrete light-absorbing portions are arranged to
provide a lower light-reflectivity than a light-reflectivity of the base structure outside the surface areas occupied by the
discontinuous discrete light-absorbing portions, and the base structure comprises a monolithic metal or polymeric support
layer coated by a lacquer comprising light-reflective particles.

US Pat. No. 9,668,608

BEVERAGE MACHINE WITH REMOVABLE LIQUID SUPPLY RESERVOIR

Nestec S.A., Vevey (CH)

1. A beverage preparation machine comprising:
a beverage preparation module;
a removable reservoir assembled to the beverage preparation module and disassemblable therefrom for removal; and
a lid for covering the removable reservoir, the lid having a fastening arrangement that secures the removable reservoir to
the beverage preparation module when the removable reservoir is assembled to the beverage preparation module, the lid being
fastened to the beverage preparation module to secure the removable reservoir to the beverage preparation module, and unfastened
from the beverage preparation module to remove the removable reservoir from the beverage preparation module,

the fastening arrangement of the lid and the beverage preparation module comprising disconnectable interconnecting parts,
the lid comprising a front portion covering the removable reservoir and a rear portion bearing the fastening arrangement,
and the lid being pivotable between the front and rear portions along a first direction to connect the interconnecting parts,
and along a second direction to disconnect the interconnecting parts.

US Pat. No. 9,598,232

FOOD OR BEVERAGE CARD COMPRISING AN ACTUATOR

Nestec S.A., Vevey (CH)

1. A method for preparing a food or beverage product from food or beverage ingredients, the method comprising the steps of:
injecting a liquid into a card containing the food or beverage ingredients, the card comprising a substantially planar and
rigid base portion, at least two ingredient compartments for storing the ingredients, and at least two discharge portions
comprising a first discharge portion and a second discharge portion, each discharge portion comprising a channel, each discharge
portion linked to one of the compartments and formed by recesses protruding from the plane of the base portion, at least one
sealing member is provided on the base portion covering the compartments and the discharge portions on the base portion side
of the card, the liquid is injected into the at least two ingredient compartments, the card is designed for insertion in a
food and beverage preparation device to dispense the ingredients from the compartments via the discharge portions, the card
comprising a flow-controlling element comprising an actuator in the discharge portions, and the actuator moves the flow-controlling
element along the plane of the base portion of the card;

activating the channel of the first discharge portion to dispense a food or beverage prepared from a first compartment of
the card; and

activating the channel of the second discharge portion to dispense a second food or beverage prepared from a second compartment
of the card.

US Pat. No. 9,486,425

4-OXO-2-PENTENOIC ACID AND LIVER DISORDERS

Nestec S.A., Vevey (CH)

1. A method for the treatment of a liver disorder comprising administering to a subject in need thereof a non-pharmaceutical
composition comprising 4-oxo-2-pentenoic acid, the liver disorder is selected from the group consisting of hepatitis, liver
fibrosis, cholestatic liver disease, inflammatory liver injury, drug-induced hepatotoxicity, ethanol-mediated hepatotoxicity,
hepatic encephalopathy, fatty liver disease, ischemia-reperfusion livery injury, liver failure, hereditary tyrosinemia type
I and hepatocellular carcinoma.

US Pat. No. 9,451,782

DEPOSITING DEVICE

NESTEC S.A., Vevey (CH)

1. A method for aerating and depositing an aerated food comprising:
pumping a food from a source of liquefied food;
adding gas from a source of gas in controlled amounts in the liquefied food to produce a gasified food;
maintaining a constant pressure of the gasified food from the adding of the gas until a piston is activated to deposit the
gasified food and retaining the product at said pressure in a chamber before a depositing point to prevent a decrease in the
pressure of the gasified food and prevent the product from expanding; and

depositing amounts of the gasified food by descending the piston in the chamber toward the depositing point to open an aperture
leading to the depositing point and force the product through the depositing point.

US Pat. No. 9,434,499

CONTAINERS HAVING IMPROVED VACUUM RESISTANCE

Nestec S.A., Vevey (CH)

1. A plastic container comprising:
a mouth configured for liquid to be introduced into and removed from the container through the mouth; and
a substantially rectangular-shaped body comprising a first cut-away portion on a first side of the body, the first cut-away
portion having a first panel that is intersected by a first rib that extends along an outer perimeter of the container in
a substantially horizontal plane, the first panel comprises two indentations formed on opposite sides of the first rib, the
first rib comprises end portions on the substantially horizontal plane that intersect sides of the first panel and comprises
a middle portion that varies in height from the substantially horizontal plane and is between the end portions, and the first
rib curves in a vertical direction such that a vertical distance from the middle portion to the mouth is different than a
vertical distance from the end portions to the mouth.

US Pat. No. 9,380,907

DISPENSER WITH HOLDING SYSTEM FOR RECEPTACLES OF DIFFERENT SIZES

Nestec S.A., Vevey (CH)

1. A beverage dispenser configured to brew, dissolve and/or froth a beverage ingredient to form a beverage and then deliver
the beverage through a beverage outlet for a consumer, the beverage dispenser comprising:
an input device configured to accept a selection of different beverages differing at least by a size of the beverage that
is dispensed;

a base;
a holding system that comprises a holding part positionable beneath the beverage outlet in order to accept a first, relatively
small receptacle, and being configured and dimensioned to be moveable between a deployed holding position suitable for accepting
the small receptacle and a second position in which the holding part is moved at least partly out of the way of the beverage
outlet to create an unoccupied space in which a second, larger receptacle can be positioned, in place of the first receptacle,
beneath the beverage outlet, the holding system comprises a sensor configured for detecting the position of the holding part
between the deployed position and the second position; and

an alerting device for causing the consumer to move the holding part of the holding system from one position to the other,
the alerting device being activated based on a comparison between the beverage selected with the input device and the position
of the holding part detected by the sensor.

US Pat. No. 9,138,096

BEVERAGE MACHINE IN A NETWORK

Nestec S.A., Vevey (CH)

1. A system for preventing shortage of consumable ingredient capsules at a customer location distant from a capsule supplier,
the system comprising:
a beverage preparation machine receiving a capsule in a capsule extraction unit, circulating a carrier liquid through the
capsule in the extraction unit, and dispensing a resulting beverage, the beverage preparation machine comprising an automatic
capsule recognition arrangement, wherein a stock of consumable ingredient capsules is supplied from the capsule supplier to
the customer location, each supplied capsule stock is individualized by a dedicated identification member located in each
capsule of the stock, and the automatic capsule recognition arrangement identifies the corresponding stock of each capsule
that is being used; and

a supplier server in data-exchange connection with the beverage preparation machine to form a network, the supplier server
automatically monitoring consumption of the consumable ingredient capsules in the beverage preparation machine, the supplier
server being programmed to (1) perform the automatic monitoring of the capsule consumption, and (2) whenever the supplier
server detects a reaching of a shortage of consumable ingredient capsules at the customer location, generating automatically
an instruction:

to invite the customer to make an order for a shipment of a new stock of capsules, or
to prepare a shipment of a new stock of capsules for supply to the customer.

US Pat. No. 9,102,424

JAW SUPPORT FOR A POUCH FILLER

Nestec S.A., Vevey (CH)

1. A fitment heater assembly comprising:
a fitment heater block;
at least one temperature probe; and
a clamp configured and arranged to secure the at least one temperature probe onto the fitment heater block, and the fitment
heater block comprises a substantially continuous face defining one or more passages for housing the at least one temperature
probe,

wherein the clamp comprises an upper clamping bracket and a lower clamping bracket that position a temperature probe housing
that contains the at least one temperature probe, and the lower clamping bracket is attached to the fitment heater block.

US Pat. No. 9,072,769

WOLFBERRIES AND SKIN INFLAMMATION

Nestec S.A., Vevey (CH)

1. A method for treating inflammation, the method comprising:
orally administering to an elderly subject in need of such treatment a product comprising an anti-inflammatory agent that
includes wolfberries or a wolfberry extract in an amount effective to treat inflammation, and milk of animal origin or a carrier
containing a milk-protein of animal milk, wherein when a wolfberry extract is used, it has a close profile of the essential
active components of whole wolfberries.

US Pat. No. 9,056,702

CLOSURE FOR CONTAINERS

Nestec S.A., Vevey (CH)

1. A closure for a container, the closure comprising:
a projection extending from a top portion of a base of the closure, the projection defining an interior having a substantially
tubular shape and comprising at least two rib members located on the interior; wherein: a) the base comprising a bottom portion
and a side portion; b) the top and bottom portions are substantially planar; c) the side portion is substantially cylindrical;
and d) wherein the projection is so constructed and arranged so as to be incompatible with an intravenous spike set, wherein
the at least two rib members are constructed and arranged to be bent in a direction that is substantially perpendicular to
a direction of insertion of a spike member into the closure, wherein the at least two rib members each comprise a face extending
substantially parallel to a vertical axis through a center of the projection, the face being exposed for contacting the spike
member.

US Pat. No. 10,028,978

USE OF WHEY PROTEIN MICELLES FOR INFANTS AT RISK OF OBESITY OR DIABETES

Nestec S.A., Vevey (CH)

1. A method for the treatment of a disorder linked to an increase in insulin secretion and/or plasma IGF-1 concentration in an infant at risk of developing obesity or diabetes, the method comprising:administering to the infant a composition comprising whey protein micelles, wherein the whey protein micelles constitute at least 30% of the protein source of the infant's daily diet, wherein a protein content of the composition ranges from 1.4 to 3.8 g per 100 kcal, and wherein the composition decreases insulin responses after ingestion of a meal relative to a composition containing an equal amount of whey protein isolates or whey protein hydrolysates.

US Pat. No. 10,028,613

DEVICE FOR PRODUCING MILK FOAM

Nestec S.A., Vevey (CH)

1. A method for producing a milk foam in a device comprising an outer cylinder, an inner cylinder arranged concentrically within the outer cylinder, a fluid inlet and a fluid outlet, the outer cylinder and the inner cylinder are rotatable with respect to each other, a gap is formed between the outer cylinder and the inner cylinder, and the gap connects the fluid inlet with the fluid outlet, the method comprising:providing a mixture of milk and air into the fluid inlet such that the mixture flows from the fluid inlet through the gap to the fluid outlet; and
rotating with respect to each other the inner cylinder and the outer cylinder to produce the milk foam, the rotating comprising creating a Couette flow of the mixture in a space between two parallel boundary plates respectively formed by an inner wall of the outer cylinder and an outer wall of the inner cylinder, a width of the gap between the inner cylinder and the outer cylinder in a radius direction is 0.1 mm to 1.0 mm such that a shear stress for the milk in the gap is 20 to 80 Pa.

US Pat. No. 9,968,112

INSTANT BEVERAGE TABLET FOR PRODUCING A LAYERED BEVERAGE

Nestec S.A., Vevey (CH)

1. An instant beverage tablet in the form of a multilayer tablet for producing a layered beverage having at least one layer selected from the group consisting of a cream layer, coffee layer and cocoa layer comprising:a dark component having sugar, coffee and/or cocoa particles for producing a dark layer;
a white component having creamer and sugar for producing white layer;
wherein the dark component is compressed with a compaction pressure of at least 250 kPa and wherein the white component is compressed with a compaction pressure of at least 1250 kPa; and
wherein the dark component has a density in the range of 0.5 to 0.7 g/cm3 and wherein the white component has a density in the range of 0.74 to 0.9 g/cm3.
US Pat. No. 9,763,465

OLIGOSACCHARIDE COMPOSITION FOR TREATING ACUTE RESPIRATORY TRACT INFECTIONS

Nestec S.A., Vevey (CH)

1. A method for relieving symptoms of otitis media or bronchiolitis, the method comprising administering a nutritional composition
comprising oligosaccharides comprising equal parts of (i) at least one N-acetyl lactosamine comprising lacto-N-neotetraose,
(ii) at least one sialylated oligosaccharide comprising 6? sialyllactose, and (iii) at least one fucosylated oligosaccharide
comprising 2? fucosyllactose to an infant or young child who suffers from a condition selected from the group consisting of
otitis media and bronchiolitis, and at least one of the sialylated oligosaccharide or the fucosylated oligosaccharide is obtained
by a process comprising a step selected from the group consisting of isolation from a natural source by filtration, isolation
from a natural source by chromatographic technology, chemical synthesis, and biotechnological synthesis.

US Pat. No. 9,668,604

CAPSULE SYSTEM FOR THE PREPARATION OF BEVERAGES BY CENTRIFUGATION

Nestec S.A., Vevey (CH)

1. A method for brewing a variety of coffee beverages of different volumes having different characteristics of taste, strength
and crema using capsules which are centrifuged in a centrifugal brewing device, the method comprising:
providing a set of capsules having a body defining different storage volumes and containing an amount of infusible or extractable
coffee ingredient that increases as a function of the storage volume of the body in the set, each capsule in the set corresponds
to a flow rate or a profile of flow rate of reference and corresponds to a particular volume of injected liquid of reference;

selecting a capsule from the set of capsules and centrifuging the capsule in the centrifugal brewing device; and
adjusting a flow rate and a volume of injected liquid in the capsule to match the flow rate or the profile of flow rate of
reference and the particular volume of the injected liquid of reference as a function of the storage volume of the capsule,
the flow rate being controlled by a method selected from the group consisting of varying a rotational speed, varying a back-pressure
exerted on a centrifuged liquid by flow restriction means pertaining to at least either the centrifugal brewing device or
the capsule or positioned on both the centrifugal brewing device and the capsule, and varying both the rotational speed and
the back-pressure exerted on the centrifuged liquid by the flow restriction means pertaining to at least either the centrifugal
brewing device or the capsule or positioned on both the centrifugal brewing device and the capsule, and the flow rate is controlled
such that the smaller the storage volume of the capsule, the smaller the flow rate.

US Pat. No. 9,518,975

ALPHA-KETO-ISOVALERATE AS A BIOMARKER OF PREBIOTIC EFFICACY FOR WEIGHT GAIN PREVENTION

Nestec S.A., (CH)

1. A method for predicting and/or quantifying the response of a subject to prebiotics in the prevention of diet induced weight
gain, comprising:
a) determining a level of alpha-keto-isovalerate in a urine sample obtained from a subject that has consumed prebiotics using
1H-NMR spectroscopy or mass spectroscopy, and

b) comparing the subject's alpha-keto-isovalerate level to a predetermined reference value by mapping or graphing the urinary
excretion of alpha-keto-isovalerate, wherein a decreased alpha-keto-isovalerate level, or an absence of change in the alpha-keto-isovalerate
level, in the urine sample compared to the predetermined reference value indicates that the administration of prebiotics is
effective in the prevention of diet induced weight gain in the subject,

and wherein the predetermined reference value is based on an average alpha-keto-isovalerate level in a control population
of subjects consuming a high fat diet and the change of alpha-keto-isovalerate level is determined relative to a cut-off value.

US Pat. No. 9,486,106

DEVICE AND METHOD FOR RETRIEVING A CAPSULE FROM A BEVERAGE PRODUCTION APPARATUS

Nestec S.A., Vevey (CH)

1. A beverage production apparatus comprising:
a housing, a cover, and a receptacle for receiving a capsule containing a beverage ingredient, wherein the cover and/or the
receptacle is moveable between a receptacle closed position and a receptacle opened position; and

a device for retrieving the capsule, the device comprising:
at least one extracting member for extracting and seizing the capsule when inserted in the receptacle, the at least one extracting
member being configured to be activated at opening of the receptacle; and

at least one guiding member coupled to the at least one extracting member and configured to be activated after extraction
of the capsule and to guide the capsule in gliding on a slope, the slope being defined by an angular position of the cover
relative to a horizontal plane,

the at least one extracting member comprises a clamp configured to seize the capsule by engaging under a rim arranged around
an upper edge of the capsule, the at least one guiding member is formed by two opposite members of the clamp that guide the
capsule along the slope, the two opposite members of the clamp are each joined together on a pair of bearings, each arranged
on the cover and linked with at least one spring configured to move the two opposite members against both sides of the capsule
at opening of the cover.

US Pat. No. 9,465,027

ASSAYS FOR DETECTING NEUTRALIZING AUTOANTIBODIES TO BIOLOGIC THERAPY

Nestec S.A., Vevey (CH)

1. A method for measuring a percent of a neutralizing form of an autoantibody to an anti-TNF? drug in a sample, the method
comprising:
(a) contacting the sample with a labeled anti-TNF? drug and a labeled TNF? to form:
(i) a first labeled complex of the labeled anti-TNF? drug and the autoantibody; and/or
(ii) a second labeled complex of the labeled anti-TNF? drug, the labeled TNF?, and the autoantibody;
(b) subjecting the first labeled complex and/or the second labeled complex to size exclusion chromatography to separate them
from free labeled TNF?, free labeled anti-TNF? drug, and/or a complex of labeled anti-TNF? drug and labeled TNF?;

(c) measuring an area under the curve (AUC) of free labeled TNF? in the sample (Free labeled TNF?AUC of the sample) after size exclusion chromatography; and

(d) measuring the percent of a neutralizing form of the autoantibody by comparing the AUC of free labeled TNF? measured in
step (c) to an AUC of free labeled TNF? in a first control sample (Free labeled TNF?AUC of the first control sample) and an AUC of free labeled TNF? in a second control sample (Free labeled TNF?AUC of the second control sample) using the equation:

((Free labeled TNF?AUC of the sample?Free labeled TNF?AUC of the first control sample)/Free labeled TNF?AUC of the second control sample)*100,
wherein the first control sample is a reference sample that is normal human serum to which labeled TNF? and labeled anti-TNF?
drug has been added, and the second control sample is a reference sample that is normal human serum to which only labeled
TNF? has been added.
US Pat. No. 9,435,784

METHODS FOR DETECTING FILM FORMATION POTENTIAL IN FOOD PRODUCTS

Nestec S.A., Vevey (CH)

1. A method for testing at least one food product for film formation potential, the method comprising:
providing a temperature-control device comprising a processor and a computer readable medium storing instructions which, when
executed, cause the processor to cycle an interior temperature of the temperature-control device between at least three temperatures
in a predetermined amount of time;

placing a packaged food product in the temperature-control device; and
causing the processor to execute the stored instructions,
determining an amount of film formed on a surface selected from the group consisting of the food product, an interior lid
on the packaged food product, an interior of the packaging, and combinations thereof; and

wherein the stored instructions, when executed, cause the processor to cycle the interior temperature of the temperature-control
device at least once.

US Pat. No. 9,434,532

CAPSULE FOR PREPARING A BEVERAGE OR FOOD LIQUID AND SYSTEM USING BREWING CENTRIFUGAL FORCE

Nestec S.A., Vevey (CH)

1. A capsule for preparing and delivering a liquid food comprising:
a dished body with a main cavity and an outer rim,
a foil membrane attached onto the outer rim,
a porous wall forming with the body an enclosure containing one or more extractable or infusible ingredients and configured
and dimensioned to have a perimeter that is radially symmetrical about a central axis to facilitate rotation of the capsule,
wherein liquid can be introduced into the capsule to form the liquid food while applying centrifugal forces to the capsule
to urge the liquid to pass through the ingredient(s); an opening arrangement comprising openings in the porous wall for allowing
liquid food to leave the enclosure after passing through the ingredient(s); and a peripheral annular recess delimited by the
outer rim and an inner edge of the dished body; the porous wall being attached to the inner edge and the inner edge being
placed below the outer rim to leave a free space between the porous wall and the foil membrane, wherein the opening arrangement
is configured and positioned near or upon the perimeter of the enclosure to allow the liquid food to travel to the peripheral
recess and to leave the capsule radially due to the application of the centrifugal forces.

US Pat. No. 9,427,002

ISOFLAVONE COMPOSITIONS FOR REDUCING ACCUMULATION OF BODY FAT IN MALE MAMMALS, AND METHODS FOR THEIR USE

Nestec S.A., Vevey (CH)

1. A method for reducing fat accumulation in a canine consuming calories in excess of its minimum daily requirement, the method
comprising identifying a canine, determining that the canine is consuming calories in excess of its minimum daily requirement,
and providing to the canine on a regular basis a comestible composition comprising one or more isoflavones that metabolize
to equol in an amount effective for reducing deposition of subcutaneous or intramuscular fat in the body of the canine.

US Pat. No. 9,417,766

BEVERAGE PREPARATION MACHINE WITH TOUCH MENU FUNCTIONALITY

Nestec S.A., Vevey (CH)

1. A beverage preparation machine comprising:
a liquid supply reservoir connected to a liquid circulation circuit comprising a pump, a heater and a brewing unit;
a memory configured to store icons divided into at least two menu level groups, each icon indicating a selectable menu function
of the beverage preparation machine;

a display configured to display:
in a first operation mode, a first group of icons in a position adjacent a main portion of the display, and
in a second operation mode, a group of currently selectable icons on the main portion of the display, the display delimiting
and extending into at least one opening configured for a function selected from the group consisting of inserting an ingredient,
providing access to a beverage outlet, and combinations thereof; and

a touch pad for accepting a touch operation for switching between the first and second operation mode.

US Pat. No. 9,376,253

BEVERAGE CAPSULE WITH AN OPENING SYSTEM

Nestec S.A., Vevey (CH)

1. A beverage capsule comprising a capsule body with an outlet, the beverage capsule comprises:
a plug configured to mate with the outlet disposed in the beverage capsule; and
an opening device at least partially fabricated from a shape-memory alloy having a transition temperature and biased to retain
the plug within the outlet in a first, closed position, thereby blocking fluid communication through the outlet, wherein the
plug is affixed to the opening device; and

the opening device is configured to deflect from the first, closed position when heated above the transition temperature of
the shape-memory alloy, thereby withdrawing the plug from the outlet into a second, open position and permitting fluid communication
through the outlet wherein the opening device comprises a resilient element fabricated from an elastic material, and a motive
element fabricated from the shape-memory alloy.

US Pat. No. 9,301,604

SHELF EXTENDER

Nestec S.A., Vevey (CH)

1. A shelf extender that is designed to be connected to a shelf of an existing shelf system to increase a total depth of a
shelf of the shelf system, said shelf extender comprising:
a body portion including a top and bottom surface, said top surface having a generally flat and planar surface, said top surface
having a width and a depth, said depth of said top surface less than a depth of a top surface of the shelf, the body portion
further comprising a front flange connected to a front edge of the top surface;

a connection arrangement lying in a same plane as said top surface of said body portion, said connection arrangement connected
to said body portion, said connection arrangement including a connector designed to secure said connection arrangement to
a top surface of the existing shelf; and

a support flange connected to the bottom surface of the body portion and comprising a rear portion that comprises a downward
extension that narrows to form a pointed or rounded tip that is a vertex of a rear edge and a front edge of the downward extension
of the support flange, the rear edge positioned at an angle between 80 and 120 degrees relative to the plane of the top surface
of the body portion, and the front edge of the rear portion is positioned at an angle between 10 and 60 degrees relative to
the rear edge of the rear portion, the front edge of the downward extension is positioned between the front flange of the
body portion and the rear edge of the support flange.

US Pat. No. 9,125,430

STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF CAROTENOIDS FOR SKIN AND HAIR

Nestec S.A., Vevey (CH)

1. A stable primary composition comprising at least one carotenoid-containing material is an oleoresin comprising a carotenoid
content from 0.05% to 50% by weight, is enriched in Z isomers of the carotenoid compound, and comprises by weight of a total
carotenoid content a greater percentage of an isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof
than of a 13-Z isomer, and contains more than 30% by weight of the total carotenoid content of the isomer selected from the
group consisting of 5-Z, 9-Z and combinations thereof, and less than 10% by weight of the total carotenoid content of the
13-Z isomer, and the Z:E isomer ratio of the carotenoid compound is between 20:80 and 95:5.

US Pat. No. 9,062,096

HER2DELTA16 PEPTIDES

NESTEC S.A., Vevey (CH)

1. A cyclic peptide having the structure:

wherein MPA is beta-mercaptopropionic acid.

US Pat. No. 9,561,901

CAPSULE HAVING A PIERCEABLE PLUG TO PREVENT BACKFLOW

Nestec S.A., Vevey (CH)

1. A capsule for use in a beverage preparation machine, the capsule comprising:
side, bottom and top walls defining a closed chamber, the chamber containing an ingredient to be dissolved and/or extracted
by a fluid injected under pressure within the capsule, the fluid being provided through an injection element of the beverage
preparation machine that is able to pierce an injection wall of the capsule;

a beverage dispensing wall able to open for releasing a beverage prepared from the ingredient and the fluid; and
a pierceable plug located adjacent to an inner side of the injection wall of the capsule and made of a resilient material,
the pierceable plug having a thickness between 0.5 mm and 10 mm, and the pierceable plug having a shape and dimensions such
as to be pierced through by the injection element when the capsule is functionally inserted within the beverage preparation
machine, the pierceable plug is supported by a plug supporting member, the pierceable plug has a ring shape concentric to
the top wall, and the plug supporting member has a plurality of openings arranged in a circular configuration that is vertically
aligned with the pierceable plug.

US Pat. No. 9,555,958

METHOD FOR PREPARING A BEVERAGE FROM A CAPSULE, CAPSULE AND BEVERAGE PREPARING SYSTEM

Nestec S.A., Vevey (CH)

1. A capsule for the preparation of a beverage in a beverage machine, the capsule comprising:
an enclosure containing one or more beverage ingredients to be brewed; and
a discharge wall that is designed to be positioned in a path of a brewed liquid and which comprises a discharge member configured
to prevent the brewed liquid from being discharged from the capsule or limit a liquid flow when a pressure inside the enclosure
is below a predetermined value, and to enable delivery of the brewed liquid when the pressure exceeds the predetermined value,
the discharge wall extending substantially from a bottom of the enclosure to a top of the enclosure, and the discharge wall
consisting of a flexible or elastic material.

US Pat. No. 9,497,986

METHOD OF IMPROVING SOLUBILITY OF ZINC IN ZINC-CONTAINING STILL DRINKING WATER AND SHELF-STABLE ZINC-CONTAINING STILL DRINKING WATER

Nestec S.A., Vevey (CH)

1. A method of improving the solubility of zinc in zinc-containing still drinking water, which is the starting drinking water,
comprising carbonating the starting drinking water, wherein the pH of the resulting drinking water is equal to or less than
7.5 and the carbon dioxide concentration in the resulting drinking water is from 5 mg/L to 1000 mg/L.

US Pat. No. 9,453,580

VALVES HAVING SEGMENTED SLEEVES AND INTERNAL SEALS

Nestec S.A., Vevey (CH)

1. A valve comprising:
a shaft having a plurality of shaft ports distributed around a circumference of the shaft;
a sleeve configured to fit concentrically around the shaft and comprising a body, the body comprises body pieces comprising
a first end piece, a second end piece, a locking piece, and at least two sealing pieces, each of the first and second end
pieces and the at least two sealing pieces housing an internal seal, the internal seal is cylindrical and comprises recessed
portions that receive o-rings positioned between the internal seal and the body; and

at least one set of a plurality of sleeve ports distributed around a circumference of the body, the plurality of sleeve ports
constructed and arranged to cooperate with the plurality of shaft ports to facilitate fluid flow.

US Pat. No. 9,445,687

BREWING OR PREPARATION CHAMBER FOR A BEVERAGE-MAKING MACHINE

Nestec S.A., Vevey (CH)

1. A brewing chamber of a beverage-making machine, which is suitable for accommodating, and extracting the contents from,
a portion capsule that is filled with pulverulent or liquid beverage base materials and comprises, in full or in part, electrically
conductive material, the brewing chamber comprising:
a fixed, first chamber part having an opener for opening the portion capsule for beverage-discharge purposes and connected
in fluid communication to a structure for an outflow of the beverage; and

a second chamber part that is movable horizontally or vertically in relation to the first chamber part, is connected in fluid
communication to an extraction-liquid-feeding extraction-liquid pump, and comprises a piercing member for opening the portion
capsule and for introducing the extraction liquid into the portion capsule,

the brewing chamber is opened for the portion capsule to be received and is closed for the portion capsule to have its contents
extracted,

the first chamber part and the second chamber part respectively comprising first and second electrically conductive contacts
that are electrically insulated from one another and are the ends of an interrupted control circuit of a checking and control
device, wherein the piercing member located in the second chamber part is the second electrical contact, and

wherein when the portion capsule is located in the closed brewing chamber, the first electrical contact of the first chamber
part and the second electrical contact of the second chamber part are in electrically conductive contact with the portion
capsule at least in an electrically conductive zone of the portion capsule, and the control circuit of the checking and control
device is closed.

US Pat. No. 9,415,931

CAPSULE FOR THE PREPARATION OF A BEVERAGE BY CENTRIFUGATION AND METHOD OF PREPARATION USING SUCH CAPSULE

Nestec S.A., Vevey (CH)

1. Capsule for the preparation of a beverage in a centrifugal brewing device by feeding liquid in the capsule and rotating
the capsule along a rotational axis in the device to produce centrifugal forces on the liquid and forcing a beverage out of
the capsule, wherein the capsule comprises containment walls containing beverage ingredients; the containment walls comprising
a bottom wall, a widening sidewall and a top wall, top wall comprises at least one liquid-impervious area and at least one
liquid-pervious and beverage filtering area; wherein the liquid-pervious and beverage filtering area is peripherally positioned
on the top wall relative to the liquid-impervious area and wherein the liquid-pervious and beverage filtering area is made
of a porous flexible material which has an elongation at break of at least 250%.

US Pat. No. 9,409,757

MIXING NOZZLE FITMENTS

Nestec S.A., Vevey (CH)

1. A method of making a beverage, the method comprising:
providing a dispensing device comprising a mixing nozzle fitment comprising a first shaft defining an inlet passage, a second
shaft defining a curved outlet passage and attached to the first shaft, a coupling member attached to the second shaft, the
coupling member defining a passage that leads into the curved outlet passage of the second shaft, and a flexible tube attached
to the coupling member, the mixing nozzle fitment positioned inside the dispensing device so that the first shaft is almost
horizontal and the second shaft is almost vertical near its end portion opposed to the attachment with the first shaft,

a fluid concentrate container attached to the end of the flexible tube of the mixing nozzle fitment opposed to the coupling
member,

a diluent dispensing nozzle removably attached to the first shaft of the mixing nozzle fitment, and
a pump operatively connected to the flexible tube; and
dispensing portions of concentrate through the mixing nozzle fitment and a diluent through the diluent dispenser nozzle, the
concentrate and the diluent being mixed in and dispensed out of the curved outlet passage of the mixing nozzle fitment to
form the beverage.

US Pat. No. 9,408,491

CAPSULE PIERCING MODULE

Nestec S.A., Vevey (CH)

1. A beverage production machine designed for producing a beverage from a capsule and having a module comprising:
a retaining means comprising a first capsule engagement member and a second capsule engagement member that co-operates with
the first capsule engagement member, wherein the first capsule engagement member can be displaced relative to the second capsule
engagement member between an opened capsule-insertion position and a closed capsule-engagement position, the first and second
capsule engagement members being relatively displaced in a combined displacement comprising a swiveling or rotating movement
when the first and second capsule engagement members are distanced from each other, and a linear displacement when the first
and second capsule engagement members are close together;

an opening means comprising a perforation member mechanically coupled to at least one of the first and second capsule engagement
members and configured to protrude into a capsule-enclosure space when the first and second capsule engagement members are
in the closed capsule-engagement position, wherein the module injects water into a capsule and drains a beverage from the
capsule while the capsule is in a closed beverage production position;

flexible capsule pre-fixation arms comprising vertical grooves so constructed and arranged to engage with a rim of the capsule
for pre-positioning the capsule and holding the capsule in place when the capsule has been inserted in the module,

the linear displacement of the first engagement member displacing the capsule from the vertical grooves in the flexible pre-fixation
arms to a final beverage position.

US Pat. No. 9,402,412

METABOLIC IMPRINTING

Nestec S.A., Vevey (CH)

1. A kit of semi solid, weaning baby food products for administration to a child during a complementary feeding period in
which the child is also consuming breast milk and/or an infant formula in addition to the semi solid, weaning baby food products,
the kit comprising:
at least two semi solid, weaning baby food products, wherein the combination of the at least two semi solid, weaning baby
food products comprises a macronutrient content that is specific for a child in an age range of from 6 months to 8 months,
and wherein the macronutrient content of the combination of semi solid, weaning baby food products and breast milk and/or
infant formula comprises from about 40% to about 50% energy from fat and from about 40% to about 49% energy from carbohydrates.

US Pat. No. 9,365,332

DISPENSING APPARATUS HAVING AN OVERCAP AND SCOOP

Nestec S.A., Vevey (CH)

1. A dispensing apparatus, comprising:
an overcap comprising:
a lid having an attachment mechanism extending from an interior surface of the lid, the attachment mechanism configured to
receive and support a scoop;

a rim hingedly attached to the lid so that the lid is movable relative to the rim between an open position and a closed position;
and

a gripper extending from the rim and having a top, a bottom, and a pair of curved protrusions defining a C-shaped recess extending
through the entire gripper from the top to the bottom in a way that the gripper is configured to receive the scoop, the gripper
extending inwardly from the rim in a way that an entirety of the gripper is in a coplanar relationship relative to the rim
such that an upper edge of the rim is free of the gripper so that the lid mates with the upper edge of the rim along the entire
circumference of the rim when the lid is in the closed position.

US Pat. No. 9,351,600

BEVERAGE MACHINES WITH SIMPLIFIED SERVICING

Nestec S.A., Vevey (CH)

1. A machine for preparing a beverage from a combination of an ingredient and a liquid, the machine comprising:
a housing comprising a front face and a back face on an opposite side of the housing from the front face, the housing containing
an infusion chamber for preparing the beverage;

a first container and a second container, the first container being a capsule receptacle and located underneath the infusion
chamber, and the second container being a liquid reservoir, such machine constructed and arranged to let a user select a quantity
ratio of the ingredient and the liquid for preparation of the beverage;

a detecting member for detecting a predetermined level of fill in at least one of the first and second containers, the detecting
member connected to a printed circuit board configured to activate an indicator to provide a single signal for indicating
to a user that both the first and second containers of the machine need an action selected from the group consisting of refilling,
emptying, and combinations thereof;

a user-interface comprising the indicator and arranged to indicate to a user the detection of the predetermined level of fill
and a message that either the first or second containers, or both, need refilling or emptying, as appropriate, before a further
beverage may be prepared;

a beverage outlet connected to the front face of the housing and configured to dispense the beverage prepared in the infusion
chamber to a dispensing area underneath the beverage outlet, the beverage outlet is at a different position from the capsule
receptacle; and

an opening in the housing configured to receive the capsule receptacle, and a distance from a front of the opening to the
back face of the housing in a horizontal direction is less than a distance from the beverage outlet to the back face of the
housing in the horizontal direction.

US Pat. No. 9,351,506

HEAT RESISTANT MOISTURE BARRIER FOR FOODS

Nestec S.A., Vevey (CH)

1. A food product comprising at least a first part and a second part, where the water activity of the first part is less than
the water activity of the second part, and a moisture barrier between the first part and the second part, the moisture barrier
is formed upon dehydration of an emulsion, the emulsion comprising lipid in the amount of 45 to 55% by weight and an aqueous
phase in the amount of 45 to 55% by weight which aqueous phase contains 1% to 4% by weight of a proteinaceous biopolymer emulsifier
and the moisture barrier contains up to 4% by weight of the emulsifier.

US Pat. No. 9,271,605

HYBRID APPARATUS FOR PREPARING BEVERAGES

Nestec S.A., Vevey (CH)

1. A device for preparing a hot beverage, comprising:
a liquid supply;
an extraction or infusion head that contains a beverage forming ingredient;
an arrangement for circulating liquid from the liquid supply to the beverage forming ingredient in the extraction or infusion
head for contact therewith to form a hot beverage that is dispensed from a beverage supply exit;

a combustion heater for supplying combustion heat to the liquid that is circulated from the liquid supply to the extraction
or infusion head and the supply exit;

an electric heater for supplying electric heat to the liquid that is circulated from the liquid supply to the extraction or
infusion head and the supply exit; and

a heat regulator configured to regulate the heat supplied to the liquid from the combustion heater and the electric heater,
the heat regulator comprising a temperature sensor which is arranged to measure directly or indirectly the temperature of
the heated liquid for comparing the measured temperature with a target temperature, the electric heater and the combustion
heater are arranged to adjust at least one of the supply of the electric heat or the combustion heat based on the difference
between the measured temperature and the target temperature,

the heat regulator further comprising a control unit that is configured to operate (i) in a first mode in which the combustion
heater supplies combustion heat to the circulating liquid while the electric heater does not supply the electric heat to the
circulated liquid, (ii) in a second mode in which the electric heater supplies electric heat to the circulating liquid while
the combustion heater does not supply the combustion heat to the circulating liquid, and (iii) in a third mode in which the
combustion heater supplies the combustion heat and the electric heater supplies the electric heat simultaneously to the circulating
liquid.

US Pat. No. 9,238,101

INFUSION PUMP CASSETTE WITH ANTI-FREE-FLOW VALVE MECHANISM

Nestec S.A., Vevey (CH)

1. A cassette for engagement with an infusion pump for delivery of a fluid to a subject comprising:
a housing having first and second ends for holding a flexible tubing through which the fluid is directed, the flexible tubing
is configured for engaging a pumping mechanism of the infusion pump that moves the fluid through the flexible tubing;

an anti-flow valve mechanism that is biased against the flexible tubing in a fluid non-delivery position to prevent flow therethrough;
a member operatively associated with the anti-flow valve mechanism to overcome the bias to allow flow of fluid through the
flexible tubing when the housing is engaged with the infusion pump;

the housing is configured and dimensioned for engagement with the infusion pump, wherein during or after engagement, the member
assumes a fluid delivery position to allow flow of the fluid through the flexible tubing, while before or as the cassette
is removed from the infusion pump, the member assumes the fluid non-delivery position to prevent flow of fluid through the
flexible tubing, the member is a tab member that is moveable between the fluid non-delivery position and the fluid delivery
position, and the tab member is designed to engage with an activation mechanism of the infusion pump, wherein the housing
has a first face, a second face, and four outside walls, wherein one outside wall has two straight wall sections and a curved
wall section between the two straight wall sections, wherein the tab member protrudes through an opening in the first face,
and the first face is fixedly connected to all four outside walls,

wherein the anti-flow valve mechanism is located at a position selected from the group consisting of 1) associated with the
flexible tubing, the cassette or the housing, and 2) situated in or near the cassette or housing;

the anti-flow valve mechanism comprises a movable member and a force applying member; and
prior to engagement of the housing with the infusion pump, the tab member and the moveable member are in the fluid non-delivery
position whereas during or after engagement, the tab member overcomes the bias and moves the movable member to the fluid delivery
position, wherein the tab member extends from a face of the movable member and is movable in a direction perpendicular to
an axis parallel to a main extension direction of the force applying member, wherein the tab member contacts the face of the
movable member.

US Pat. No. 9,232,811

PARTICLES OF AERATED ICE CONFECTION PRODUCTS FOR FROZEN ICE DRINKS

Nestec S.A., Vevey (CH)

1. A packaged ready to use frozen ice drink product which comprises a container and aerated ice confection particles prepared
according to a process comprising:
preparing an elongated frozen stream of an aerated ice confection;
freezing the stream cryogenically to a temperature below the glass transition temperature (Tg) of the aerated ice confection
to form an amorphous glass-like solid mass that is not sticky and that has minimal surface-adhesive properties;

comminuting the solid mass to free-flowing aerated ice confection particles;
exposing the free-flowing aerated ice confection particles to cryogenic freezing in which the particles are subjected to a
temperature of ?25° C. to ?30° C. to obtain hardened free-flowing aerated ice confection particles;

coating the hardened free-flowing aerated ice confection particles with an aqueous solution of a Tg elevating agent comprising
partially enzymatically degraded starch syrup having dextrose equivalents between 1 and 10 and a molecular weight of 5 kD
to 15 kD; and

exposing the coated hardened free-flowing aerated ice confection particles to a cryogenic freezing in which the particles
are subjected to a temperature of ?30° C. to ?35° C. to form further hardened free-flowing aerated ice confection particles
that have a Tg of ?5° C. to ?35° C.

US Pat. No. 9,198,445

WHEY PROTEIN VEHICLE FOR ACTIVE AGENT DELIVERY

Nestec S.A., Vevey (CH)

1. Protein micelle aggregates of denatured whey proteins having a molecular size smaller than 1 micron and containing an active
agent, with the whey proteins arranged so that hydrophilic parts of the proteins are oriented towards outer parts of the aggregates
and hydrophobic parts of the proteins are oriented towards the inner portions of the micelles, wherein the aggregates are
obtainable by a method which comprises:
adjusting the pH of a demineralised native whey protein solution to a value between 5.8 and 6.0, and heating the solution
to a temperature of 80° C. to 98° C. for 10 seconds to 2 hours to obtain negatively charged whey protein micelles;

dispersing the negatively charged whey protein micelles and the active agent in a solvent, and
evaporating the solvent,
wherein the whey protein in the micelles is denatured.

US Pat. No. 9,169,049

DEVICES SUITABLE FOR REMOVING, PREPARING, AND STORING MATERIALS

Nestec S.A., Vevey (CH)

1. A device comprising (1) an elongated portion defining a handle and a blade, the blade comprising a straight edge side,
an opposing edge side having a plurality of ribs, and a squared edge at an end of the straight edge side of the blade and
(2) an over-cap attached to the elongated portion.

US Pat. No. 9,155,322

FROZEN CONFECTIONERY PRODUCT WITH LAYERED STRUCTURE AND APPARATUS FOR MANUFACTURING SAME

Nestec S.A., Vevey (CH)

1. An apparatus for making a frozen confectionery product by rotary vertical extrusion into a container, the apparatus comprising:
a nozzle;
at least one ice-cream passage with at least one inlet port and an outlet port;
at least one chocolate passage with at least an inlet port and at least two outlet ports, the chocolate passage is insulated
from the ice-cream passage and joins the ice-cream passage only at the outlet port of the ice-cream passage such that the
outlet port of the at least one ice-cream passage is in the same plane as the at least two outlet ports of the at least one
chocolate passage;

the outlet ports are located in the nozzle and have elongated cross-sections, and the chocolate outlet port extends parallel
to, and in the same direction as, the ice cream outlet port, so as to form an annular or helical chocolate layer upon rotation
of the nozzle and the container with respect to each other.

US Pat. No. 9,061,782

FITMENT INDEXER FOR A POUCH FILLER

Nestec S.A., Vevey (CH)

6. A feed conveyor system comprising:
a support frame;
a fitment rail assembly attached to the support frame; and
a fitment indexing module attached to the support frame, the fitment indexing module comprising a pneumatic actuator and an
actuator plate attached to the pneumatic actuator, the actuator plate defining a curved portion that is so constructed and
arranged to receive a fitment for partially housing the fitment when the curved portion is directly positioned in a pathway
of the fitment in the fitment rail assembly.

US Pat. No. 10,071,844

MULTI-COMPARTMENT PRODUCTS CONTAINING WET AND DRY FOOD COMPONENTS

Nestec S.A., Vevey (CH)

1. A multi-component food product, consisting of:a single unitary tray of one piece construction comprising a top surface and at least a first compartment and a second compartment separate from each other;
a wet, flowable food component positioned within and in direct contact with the first compartment in a way that the wet, flowable food component wets the unitary tray of one piece construction;
a dry, solid food component positioned within and in direct contact with the second compartment; and
a single lid secured to the top surface of the tray to seal the first compartment and the second compartment in a way to prevent cross-contamination between the wet food component and the dry food component,
wherein each of the wet food component and the dry food component is free of any artificial preservatives.
US Pat. No. 9,560,869

FOOD COMPOSITION COMPRISING DESFERRICHRYSIN

Nestec S.A., Vevey (CH)

1. A non-beverage food composition comprising desferrichrysin, iron, phenolic chromophore compounds and culinary fruit selected
from the group consisting of blackcurrant, cranberry, elderberry, red currant, boysenberry, grape, cherry, orange, lemon,
lime, mandarin, tangerine, grapefruit, pineapple, mango, papaya, passion fruit, kiwifruit, guava, fig, date, apple, plum, strawberry, raspberry, blueberry, blackberry, apricot, pear, banana,
quince, wolfberry and mixtures thereof.
US Pat. No. 9,482,672

METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME

Nestec S.A., Vevey (CH)

1. A method for aiding in the diagnosis of irritable bowel syndrome (IBS) in a subject, said method comprising:
(a) contacting a blood or serum sample from the subject with a prostaglandin E2 (PGE2) antibody under conditions suitable to transform PGE2 present in the sample into a complex comprising PGE2 and the PGE2 antibody;

(b) detecting the level of said complex using a sandwich enzyme-linked immunosorbent assay (ELISA) comprising an alkaline
phosphatase conjugated anti-PGE2 antibody as the detecting antibody and a disodium 3-(4-methoxyspiro{1,2-dioxetane-3,2?-(5?-chloro)tricyclo[3.3.1.13,7]decan}-4-yl)phenyl
phosphate (CPSD) containing luminescent substrate to enhance assay sensitivity, thereby determining the level of PGE2 present in the sample; and

(c) comparing the level of PGE2 present in the sample to a control level, wherein a difference in the level of PGE2 present in the sample relative to the control level is indicative of an increased likelihood of said subject having IBS.

US Pat. No. 9,445,688

CAPSULE PROVIDED WITH A CODE AND AUTOMATED BEVERAGE PREPARATION SYSTEM

Nestec S.A., Vevey (CH)

1. A capsule for delivering a beverage in a beverage preparation machine, the capsule comprising:
a code support surface on which a code is represented, the code comprising a first value for at least one capsule-related
information, characterised in that the code further comprises a first element and a second element arranged on the code support
surface so that the distance between the first element and the second element is a function of the first value, and wherein
the first value is comprised between a minimum value and a maximum value, the first element and the second element being arranged
on the code support surface so that the distance between the first element and the second element is a function of the difference
between the first value and the minimum value or the maximum value.

US Pat. No. 9,415,918

PACKAGING FOR CONSUMABLE PRODUCTS AND METHODS FOR USING SAME

Nestec S.A., Vevey (CH)

1. A flexible package comprising:
a pair of flexible, impermeable layers sealed to form a body defining a cavity for housing a flowable product and a channel,
in fluid communication with the cavity, for dispensing the flowable product from the cavity, the channel having a bottom adjacent
the cavity and a closed end opposite the bottom, the closed end being removable to form an open end and permit the flowable
product to be dispensed from the cavity through the channel, the channel having a width extending from one sealed portion
to an opposing sealed portion, a length extending from the bottom to the closed end, and an area of reduced width to impede
the flow of the flowable product from the bottom of the channel to the open end thereof when the closed end is removed,

wherein the width of the channel is substantially constant on each side of the area of reduced width, and
wherein the width of the channel on one side of the area of reduced area is substantially the same as the width of the channel
on the other side of the area of reduced width.