US Pat. No. 9,289,142

IMPLANTABLE ELECTRODE LEAD SYSTEM WITH A THREE DIMENSIONAL ARRANGEMENT AND METHOD OF MAKING THE SAME

NeuroNexus Technologies, ...

1. A shim assembly for an implantable electrode lead, the shim assembly comprising:
a) a first shim surface spaced apart from a second shim surface by a shim sidewall having a sidewall thickness; and
b) at least a first recess in the shim sidewall spaced apart from a second recess in the shim sidewall, both the first and
second sidewall recesses residing at the first shim surface and extending into a portion of the sidewall thickness, but spaced
from the second shim surface; and

c) a receptacle that is open to the first shim surface and meets the first and second recesses at the shim sidewall, wherein
the receptacle has a depth that only extends part way through the sidewall thickness so that the receptacle does not meet
the second shim surface.

US Pat. No. 9,717,912

METHOD AND SYSTEM FOR DETERMINING SETTINGS FOR DEEP BRAIN STIMULATION

MEDTRONIC BAKKEN RESEARCH...

1. A method comprising:
applying, via a probe, test stimulation to tissue of a patient;
measuring a result of the test stimulation and determining therefrom at least one of an impedance value or an admittance value
of the tissue;

determining a target field that will stimulate a selected portion of the tissue; and
determining, via a processor, and based on the at least one of the impedance value or admittance value of the tissue, one
or more stimulation settings to generate the target field that will stimulate the selected portion of the tissue,

wherein determining the target field that will stimulate a selected portion of the tissue comprises at least one of receiving
an indication of one or more target anatomical structures of the patient or receiving an indication of anatomical structures
for which stimulation should be avoided,

wherein receiving an indication of one or more target anatomical structures of the patient comprises receiving a set of coordinates
of positions of the one or more target anatomical structures.

US Pat. No. 9,248,269

NEURAL DEVICE WITH MODULAR ELECTRODE ARRAY

NeuroNexus Technologies, ...

1. A modular electrode array, comprising:
a) a first electrode module, comprising:
i) a first flexible substrate comprising a first perimeter; and
ii) at least two first electrodes supported on a first side of the first substrate,
iii) wherein the at least two first electrodes are spaced apart from each other by a first pitch length of the first substrate;
b) a second electrode module, comprising:
i) a second flexible substrate comprising a second perimeter; and
ii) at least two second electrodes supported on a first side of the second substrate,
iii) wherein the at least two second electrodes are spaced apart from each other by a second pitch length of the second substrate;
c) a first connector substrate extending along a first longitudinal axis from a first connector end to a second connector
end, wherein:

i) the first connector end is connected to the first substrate perimeter and the second connector end is connected to the
second substrate perimeter to thereby provide a spatial separation between the first and second modules, and

ii) wherein the first longitudinal axis of the first connector substrate intersects both the first pitch between and spaced
from the two first electrodes and the second pitch between and spaced from the two second electrodes; and

d) at least two first conductive interconnects and at least two second conductive interconnects, each of the first and second
conductive interconnects extending from a proximal interconnect end to a distal interconnect portion having a distal interconnect
end,

i) wherein the proximal first and second interconnect ends are configured for electrical connection to an external electrical
device, and

ii) wherein the distal portions of the first conductive interconnects are supported by the first flexible substrate with the
first distal interconnect ends electrically coupled to respective ones of the at least two first electrodes, and

iii) wherein the distal portions of the second conductive interconnects are supported by the first flexible substrate, the
first connector substrate, and the second flexible substrate with the second distal interconnect ends electrically coupled
to respective ones of the at least two second electrodes; and

e) a backing supporting the first and second substrates and the intermediate first connector substrate on respective second
sides thereof opposite the first sides to thereby maintain the spatial separation between the first and second modules.

US Pat. No. 9,155,861

NEURAL DRUG DELIVERY SYSTEM WITH FLUIDIC THREADS

NeuroNexus Technologies, ...

1. A neural drug delivery system, which comprises:
a) at least one fluid delivery conduit comprising a conduit sidewall defining a lumen configured to transport fluid;
b) at least two fluid delivery ports extending through the conduit sidewall;
c) a respective port gate supported by the conduit sidewall at each of the at least two fluid delivery ports, each port gate
comprising:

i) a thin-film mesh structure; and
ii) an electroactive polymer supported by at least a portion of the mesh structure,
d) wherein each port gate is selectively operable between the following modes:
i) in the absence of a conductive signal applied to the electroactive polymer, the polymer is stable in an oxidized and expanded
state occluding the mesh structure to thereby provide the port gate in a closed mode that prevents transfer of the fluid through
the corresponding fluid delivery port; and

ii) in response to a conductive signal applied to the electroactive polymer, the polymer volumetrically contracts to thereby
provide an open mode that allows transfer of the fluid through the fluid delivery port;

e) a voltage source that provides the conductive signal to the electroactive polymer of the port gates; and
f) an interconnect network configured to carry the conductive signal to the port gates from the voltage source.

US Pat. No. 9,205,252

MEDICAL DEVICE FOR ELECTRICAL STIMULATION

MEDTRONIC BAKKEN RESEARCH...

1. A medical device for electrical stimulation, the device comprising:
an implantable elongated lead system having a distal end and a proximal end, the lead system comprises one or more electrical
conductors for connection to one or more electrodes,

wherein the one or more electrical conductors are wound along a length axis of the lead system with a plurality of windings
that extend to the distal end, and

wherein spacing between any adjacent two of the plurality of windings is larger than spacing between any other more distal
adjacent two of the plurality of windings.

US Pat. No. 9,700,736

NEUROMODULATION TRANSFECTION SYSTEM WITH ACTIVE FLUID DELIVERY

NEURONEXUS TECHNOLOGIES, ...

10. A method for optical stimulation using an implanted neural interface array, the neural interface array being located at
an implantation site in a subject, the neural interface array including an optical waveguide having one or more optical apertures
along its longitudinal axis, a thin film electrode array having a plurality of electrodes, one or more optical ports, and
one or more fluidic ports, and a fluid delivery channel having one or more fluidic apertures along its longitudinal axis,
wherein the one or more optical apertures are approximately aligned with the one or more optical ports, and the one or more
fluidic apertures are approximately aligned with the one or more fluidic ports, the method comprising:
delivering fluid to the implantation site using the fluid delivery channel;
optically stimulating using the optical waveguide; and
sensing an electrical signal using one of the plurality of electrodes.

US Pat. No. 9,656,054

IMPLANTABLE ELECTRODE AND METHOD OF MAKING THE SAME

NEURONEXUS TECHNOLOGIES, ...

1. An implantable electrode, comprising:
a) a first portion of an insulator layer;
b) an electrically conductive interconnect layer supported by the first portion of the insulator layer, the interconnect layer
comprising an interconnect peripheral edge providing an interconnect width or diameter extending between spaced apart first
and second interconnect edges;

c) an electrically conductive plug layer supported directly on an upper interconnect surface of the interconnect layer, the
plug layer comprising a plug peripheral edge providing a plug width or diameter extending between spaced apart first and second
plug edges;

d) a second portion of the insulator layer supported on the first portion of the insulator layer and contacting the plug;
e) an electrically conductive electrode layer supported directly on an upper plug surface of the plug layer, the electrode
layer comprising an electrode peripheral edge providing an electrode width or diameter extending between spaced apart first
and second electrode edges; and

f) an anchor layer that overlaps only parts of the electrode layer including at least one of the first and second electrode
edges, wherein the anchor layer is physically and electrically isolated from the interconnect layer and the plug layer by
the insulator layer.

US Pat. No. 9,844,660

THREE-DIMENSIONAL NEURAL PROBE MICROELECTRODE ARRAY AND METHOD OF MANUFACTURE

NEURONEXUS TECHNOLOGIES, ...

1. A method for manufacturing a neural probe electrode assembly, the method comprising:
providing a platform workpiece comprising a sidewall and having a thickness extending between spaced apart upper and lower
face walls, wherein an oxide layer resides in the platform workpiece between the upper and lower face walls and is sandwiched
between a first silicon layer and a second silicon layer;

providing an upper mask on the upper face wall and a lower mask on the lower face wall, wherein the upper and lower masks
provide respective upper and lower perimeters outlining a shape of a slot to be provided through the thickness of the platform
workpiece, wherein the slot is configured to receive a neural probe array;

etching from the upper face wall partway through the thickness of the platform workpiece to the oxide layer to thereby provide
an upper portion of the slot bounded by and spaced from the sidewall; and

etching from the lower face wall a remaining portion of the thickness of the platform workpiece including the oxide layer
to thereby provide a finished platform having a lower portion of the slot bounded by and being spaced from the sidewall, wherein
the finished platform has the upper and lower portions of the slot in open communication with each other to provide the slot
extending to the upper and lower platform surfaces.

US Pat. No. 10,034,615

METHOD FOR IMPLANTING AN IMPLANTABLE DEVICE IN BODY TISSUE

NeuroNexus Technologies, ...

1. A method for implanting and using a neural interface device, comprising the steps of:a) providing the neural interface device, comprising:
i) a carrier extending along a first carrier length from a proximal carrier portion to a distal carrier portion having a distal carrier end, wherein the carrier is of a bioresorbable material that is absorbable into body tissue after implantation;
ii) a first electrical subsystem, comprising:
A) a plurality of electrode sites configured to interface with neural tissue; and
B) an electrode substrate having a tubular shape and supporting the plurality of electrode sites; and
iii) an electrical connector extending from each of the plurality of electrode sites to a proximal connector portion adjacent to the proximal carrier portion,
iv) wherein at least a portion of the electrode substrate is woven with the carrier so that the plurality of electrode sites extend circumferentially relative to the first carrier length of the carrier and have exposed surfaces facing outwardly from the electrode substrate opposite the carrier;
b) implanting the neural interface device comprising the carrier, the first electrical subsystem, and the electrical connector into body tissue; and
c) permitting the neural interface device to remain implanted for a sufficient amount of time so that the carrier is absorbed into the body tissue, thereby leaving at least one of the plurality of electrode sites facing outwardly toward the neural tissue from the supporting electrode substrate.

US Pat. No. 9,782,091

OPTO-ELECTRICAL DEVICE FOR ARTIFACT REDUCTION

NEURONEXUS TECHNOLOGIES, ...

17. An optical electrode device, comprising:
a) a carrier;
b) a plurality of electrodes supported on the carrier, wherein:
i) at least one of the electrodes is a stimulation electrode configured to provide electrical stimulation to tissue, and wherein
the stimulation electrode has an unroughened external surface with an average roughness that is less than 10 nm; and

ii) at least one of the electrodes is a recording electrode configured to sense electrical signals from tissue, and wherein
the recording electrode has a roughened external surface comprising:

A) an electrically conductive material selected from the group consisting of gold, platinum, iridium, platinum-iridium, titanium
nitride, and iridium oxide; and

B) a roughened external material having a back side attached to the electrically conductive material to thereby provide the
recording electrode with a roughened external surface forming a front side of the roughened external material, wherein the
roughened external material is selected from the group consisting of PEDOT/PSS (poly(3,4-ethylene-dioxythiophene)/poly(styrene
sulfonate), glass nanospheres, glass microspheres, poly-styrene nanospheres, and poly-styrene microspheres, and

C) wherein the roughened external surface of the recording electrode has an average roughness as an arithmetic average of
absolute values of a series of maximum and minimum vertical height measurements in nm on the roughened external surface of
the recording electrode that is greater than 10 nm; and

c) a light source supported by the earner, the light source configured to emit light that is directed at the roughened external
surface of the recording electrode.

US Pat. No. 9,636,028

THREE-DIMENSIONAL NEURAL PROBE MICROELECTRODE ARRAY AND METHOD OF MANUFACTURE

NEURONEXUS TECHNOLOGIES, ...

1. A neural probe system, which comprises:
a) a skull mounting plate, comprising:
i) a mount body configured to be supported on a skull of a subject; and
ii) at least two first openings extending through the mount body;
b) at least two first threaded screws configured for registry in the at least two first openings of the mount body to threadingly
mount the skull mounting plate to the skull;

c) a housing configured to house electronics and to be detachably supported on the skull mounting plate;
d) an electrical cable extending from a proximal cable portion having a proximal cable end to a distal cable end, wherein
the proximal cable end is detachably electrically connected to electronics housed in the housing with the proximal cable portion
extending through an opening in the housing;

e) at least one neural probe electrode assembly comprising a proximal probe end spaced from a distal probe portion having
a distal probe end, wherein the proximal probe end is electrically connected to the distal cable end and wherein the distal
probe portion has at least one neural probe electrode array configured for electrical stimulation of body tissue or recording
of biological characteristics of the body tissue; and

f) a cradle supported on the housing, wherein the at least one neural probe electrode array is configured to be nested in
the cradle prior to placement in a body tissue, and

wherein after the housing is supported on the skull mounting plate mounted to the skull by the at least two first threaded
screws received in respective ones of the at least two first openings and threaded into the skull, the at least one neural
probe electrode array is accessible from outside the housing for placement in a body tissue.

US Pat. No. 10,052,476

METHODS FOR FORMING AN ELECTRODE DEVICE WITH REDUCED IMPEDANCE

NeuroNexus Technologies, ...

1. A method for providing a neural interface system, comprising the steps of:depositing at least one primary metallization layer supported on the substrate, the metallization layer having a thickness;
depositing a monolayer of nanospheres contacting an upper surface of the primary metallization layer; and
treating the upper surface of the primary metallization layer not covered by the nanospheres to thereby form a plurality of pyramidal structures the treating comprising depositing a secondary metallization layer on exposed portions of the primary metallization layer, thereby forming the plurality of pyramidal undulating structures, removing the nanospheres from the substrate and then configuring the substrate supporting the primary metallization layer with plurality of pyramidal structures for contact with body tissue as a component of a neural interface device.

US Pat. No. 9,643,027

WAVEGUIDE NEURAL INTERFACE DEVICE

NEURONEXUS TECHNOLOGIES, ...

1. A method of assembling a waveguide neural interface device, comprising the steps of:
a) providing a substrate comprising a first proximal substrate branch and a second proximal substrate branch extending proximally
from at least a distal substrate portion;

b) mounting at least one waveguide to the substrate, wherein the waveguide is configured to carry light along a light path
from a proximal waveguide portion supported at the first proximal substrate branch to a distal waveguide portion including
at least one distal light directing element supported at the distal substrate portion, the light directing element being configured
to emit light carried by the waveguide away from a longitudinal axis of a distal portion of the light path;

c) supporting at least one electrode site on the distal substrate portion, wherein the at least one electrode site is electrically
connected to an interconnect supported on the second proximal substrate branch;

d) providing a circuit board comprising a first circuit board face delineated from a second circuit board face by a fold line;
e) mounting the first and second proximal substrate branches supporting the respective proximal waveguide portion and the
interconnect to the first circuit board face;

f) mounting a light source to the second circuit board face; and
g) folding the circuit board along the fold line to thereby move the respective first and second circuit board faces into
close proximity with each other so that the light source is positioned to shine light into the proximal waveguide portion
at the first proximal substrate branch so that the shone light travels along the light path to then be emitted from the waveguide
adjacent to the at least one electrode site by the light directing element at the distal substrate portion.

US Pat. No. 10,252,047

NEURAL INTERFACE SYSTEM WITH EDGE ARRAY

NEURONEXUS TECHNOLOGIES, ...

1. A method of making a neural interface system, comprising:a) forming a planar polymer substrate with at least one metallization layer;
b) patterning, on at least one metallization layer, an electrode array on a first end of the substrate;
c) patterning a plurality of conductive traces on at least one metallization layer;
d) rolling a portion of the substrate toward the first end of the substrate; and
e) securing the rolled substrate into a shaft having the first end of the substrate laterally extending from the shaft and the electrode array radially offset from the shaft such that the electrode array is not on the shaft.

US Pat. No. 10,493,297

NEUROMODULATION TRANSFECTION SYSTEM WITH PASSIVE FLUID DELIVERY

NeuroNexus Technologies, ...

24. An implantable neural device, comprising:a substrate having a substrate thickness extending from a first substrate face to a spaced apart second substrate face, wherein the first and second substrate faces extend from a proximal substrate portion to a distal substrate portion, and wherein the substrate is planar and has a plurality of lateral edges;
a plurality of electrodes supported by the substrate, wherein the plurality of electrodes includes a neurosensing electrode, a neurostimulation electrode, and an electroporation electrode;
a conductive trace extending from one of the plurality of electrodes to a proximal trace end at the proximal substrate portion, wherein the proximal trace end is electrically connectable to an external instrumentation;
a waveguide extending from a proximal waveguide portion to a distal waveguide portion, wherein the proximal waveguide portion is connectable to a light source;
an aperture extending from the first substrate face through the substrate thickness to the second substrate face in the distal substrate portion, wherein the distal waveguide portion is supported by the second substrate face adjacent to the aperture;
a cavity at the distal substrate portion and extending partway through the substrate thickness from an opening in the first substrate face; and
a delivery capsule in the cavity, wherein the delivery capsule comprises a biologic or bioactive agent adapted to induce a light-sensitive or therapeutic response from body tissue at a particular tissue location at which the implantable neural device is implanted,
wherein the plurality of electrodes is substantially co-localized with the cavity and the aperture such that a same portion of the body tissue at the particular tissue location that includes targeted cells that receive the biologic or bioactive agent is also at least one of electropermeabilized by the electroporation electrode, sensed by the neurosensing electrode, or electrically stimulated by the neurostimulation electrode in a single procedure;
wherein at least two of the plurality of electrodes are located on the first substrate surface adjacent to the cavity and closer to a lateral edge of the plurality of lateral edges of the substrate than the cavity; and
wherein at least two other electrodes of the plurality of electrodes are located closer to the lateral edge than the light source.

US Pat. No. 10,231,636

OPTO-ELECTRICAL DEVICE AND METHOD FOR ARTIFACT REDUCTION

NeuroNexus Technologies, ...

1. An optical electrode device, comprising:a carrier;
a plurality of electrodes supported on the carrier, at least one of which is a recording electrode configured to sense electrical signals from tissue, wherein the recording electrode comprises:
an electrically conductive material; and
a roughened external material having a back side attached to the electrically conductive material to thereby provide the recording electrode with a roughened external surface forming a front side of the roughened external material, and
wherein the roughened external surface of the recording electrode has an average roughness as an arithmetic average of absolute values of a series of maximum and minimum vertical height measurements in nm on the roughened external surface that is greater than 10 nm; and
a light source supported by the carrier, the light source configured to emit light that is directed at the roughened external surface of the recording electrode.

US Pat. No. 10,118,030

OMNIDIRECTIONAL DEPLOYABLE MULTICHANNEL NEURAL ELECTRODE SYSTEM

NeuroNexus Technologies, ...

1. A neural intervention system, comprising:a guide tube comprising a guide tube sidewall extending along a longitudinal axis from a proximal guide tube portion having a proximal guide tube end to a distal guide tube portion having a distal guide tube end, wherein a tube lumen extends from the proximal guide tube end to at least the distal guide tube end;
a plurality of deployment channels disposed inside the guide tube, each of the plurality of deployment channels comprising a channel sidewall defining a channel lumen extending from a proximal channel open end to a distal channel open end as an open port at the guide tube sidewall, wherein the proximal channel open end of a first deployment channel of the plurality of deployment channels resides at a first location along a first imaginary plane aligned substantially perpendicular to the longitudinal axis and wherein the proximal channel open end of a second deployment channel of the plurality of deployment channels resides at a second location along the first imaginary plane radially closer to the longitudinal axis;
an actuation mechanism having a length extending from a proximal actuation end to a distal actuation portion; and
a plurality of neural probes that is registered with the plurality of deployment channels and that is connected to a manifold attached to the distal actuation portion of the actuation mechanism, at least one neural probe extending from a proximal probe end to a distal probe portion having a distal probe end,
wherein the distal probe portion has at least one electrode configured for electrical stimulation of body tissue or recording of biological characteristics, and wherein at least the distal probe end is received in at least one deployment channel of the plurality of deployment channels; and
wherein the proximal probe end is connected to the distal actuation portion, the proximal actuation end is movable in a distal direction along the longitudinal axis to cause the at least one neural probe to move through the at least one deployment channel and out the distal channel open end to thereby move the at least one electrode into a body tissue.

US Pat. No. 10,694,631

MAGNETIC ACCESS PANEL

NEXUS TECHNOLOGIES, INC.,...

1. A magnetic access panel for use with a carrying case having a case housing and containing an electronic apparatus, said magnetic access panel comprising:a substantially planar body having a first side and a second side, and a first end and a second end; and
a pivotable coupling configured to attach the first end of the planar body to a surface of the case housing,
wherein the first and second sides of the planar body are configured to be magnetically affixed to the surface of the case housing, and wherein the planar body is configured to be pivotable between and magnetically secured within a first recessed area of the carrying case and a second recessed area of the carrying case.

US Pat. No. 10,173,051

NEURAL ELECTRODE SYSTEM WITH A CARRIER HAVING A TAPE SPRING-TYPE SHAPE

NEURONEXUS TECHNOLOGIES, ...

1. A neural probe, which comprises:a tape spring-type carrier having a carrier thickness extending along a carrier length between a first major surface of the tape spring-type carrier and a second major surface of the tape spring-type carrier extending from a proximal carrier end to a distal carrier portion having a distal carrier end,
wherein the first major surface is opposite the second major surface;
wherein the tape spring-type carrier has a stiff, curved U-beam state along the carrier length when in an unstressed condition;
wherein, when a section of the tape spring-type carrier is moved through a bend, the section in the bend flattens;
wherein, when the section of the tape spring-type carrier is moved past the bend, the section returns to the stiff, curved U-beam state; and
wherein the proximal carrier end is electrically connectable to a source of electrical energy;
a first polymeric layer;
a second polymeric layer, wherein the tape spring-type carrier is sandwiched between the first polymeric layer and the second polymeric layer such that the first polymeric layer and the second polymeric layer contact the first major surface and the second major surface, respectively; and
at least one electrode configured for electrical stimulation of body tissue or recording of biological characteristics supported on the tape spring-type carrier, wherein the at least one electrode is supported on at least one of the first and second major surfaces.

US Pat. No. 10,688,298

IMPLANTABLE ELECTRODE AND METHOD OF MAKING THE SAME

NEURONEXUS TECHNOLOGIES, ...

1. A method for controlling charge distribution of an implantable electrode comprising:forming an interconnect structure over a base layer;
forming an anchoring structure over the base layer;
depositing an insulating material layer over the interconnect structure and over the anchoring structure;
exposing a portion of the interconnect structure through the insulating material layer;
exposing a portion of the anchoring structure through the insulating material layer;
forming a first plug over the exposed portion of the interconnect structure;
forming a second plug over the exposed portion of the anchoring structure; and
forming an electrode site that extends over the insulating material layer, the first plug, and the second plug, the electrode site being electrically coupled to the exposed portion of the interconnect structure via the first plug and to the exposed portion of the anchoring structure via the second plug.

US Pat. No. 10,669,762

HINGE

Nexus Technologies, Inc.,...

1. A hinge assembly for rotatably coupling opposing halves of a housing of a carrying case containing electronic components, said hinge assembly comprising:at least two hinge segments, each comprising a first hollow semi-cylinder joined to a second hollow semi-cylinder by a living hinge, the opposing semi-cylinders forming a hollow cylinder when brought together, the at least two hinge segments configured to rotate about a common axis and creating a continuous central channel therethrough when aligned in linear fashion; and
a hollow, tubular connecting rod,
wherein the central channel of the at least two hinge segments is configured to receive the hollow, tubular connecting rod therein, and wherein the at least two hinge segments are configured to be secured together, and wherein the connecting rod is formed from a first hollow semi-cylinder joined to a second hollow semi-cylinder by a living hinge, the opposing semi-cylinders defining a continuous central passage when brought together, and wherein the central passage is configured to receive one or more electrical conductors therethrough.