US Pat. No. 9,533,140

MICROELECTRODE AND MULTIPLE MICROELECTRODES

NEURONANO AB, (SE)

1. A medical microelectrode for insertion into soft tissue, the medical microelectrode comprising:
an electrically conducting elongate electrode body including a first proximal end, and a second distal end, the electrode
body comprising:

a tip section extending from the distal end;
a main body section extending in a proximal direction from the tip section,
wherein the tip section, and the main body element are embedded in a first electrode matrix element, which is substantially
rigid, biocompatible and soluble or biodegradable in a body fluid; and

a second electrode matrix element, different from the first electrode matrix element, the second electrode matrix element
positioned such that the first electrode matrix element is positioned between the second electrode matrix element and the
electrode main body,

wherein at least one of the first electrode matrix element and the second electrode matrix element comprises a drug configured
to be released upon dissolution or biodegradation of the first electrode matrix element,

wherein the electrode body comprises a non-conducting core, at least one electrically conducting layer on the core, and an
insulating layer on the one or more electrically conducting layers,

wherein the first electrode matrix element comprises a first drug, and the second electrode matrix element comprises a second
drug different from the first drug.

US Pat. No. 9,610,456

NANOWIRE-BASED DEVICES FOR LIGHT-INDUCED AND ELECTRICAL STIMULATION OF BIOLOGICAL CELLS

NEURONANO AB, Karlshamn ...

1. A device, comprising:
at least one photovoltaic cell and at least one nanowire configured to electrically stimulate a biological material in response
to radiation, wherein the radiation is solar radiation or UV, visible or IR radiation from a lamp or laser;

a hydrophobic seal located around a first portion of the nanowire, the hydrophobic seal exposing a protruding second portion
of the nanowire configured as an intracellular electrode; and

a first insulating shell located around the nanowire;
wherein:
the hydrophobic seal comprises an edge seal comprising a hydrophobic material shell located between the nanowire and the first
insulating shell;

the edge seal comprises an edge surface that extends substantially perpendicular to a longitudinal axis of the nanowire and
that is exposed by the first insulating shell, for contacting the inside of a biological cell membrane.

US Pat. No. 9,878,147

MICROELECTRODE AND MULTIPLE MICROELECTRODES

NEURONANO AB, (SE)

1. A medical microelectrode bundle comprising at least two medical microelectrodes configured to be inserted into soft tissue,
each medical microelectrode comprising:
an electrically conducting elongate electrode body comprising a first proximal end, and a second distal end, the electrode
body comprising:

a tip section extending from the distal end;
a main body section extending in a proximal direction from the tip section,
wherein the tip section, and the main body section are embedded in a first electrode matrix section, which is substantially
rigid, biocompatible and soluble or biodegradable in a body fluid; and

a second electrode matrix section comprising at least one of a sugar and agarose, and positioned such that at least a significant
part of the first electrode matrix section is positioned between the second electrode matrix section and the electrode main
body,

wherein a drug configured to be released upon dissolution or biodegradation of the first electrode matrix element section
comprises the first electrode matrix section or the second electrode matrix section,

wherein the at least two medical microelectrodes comprise electrode bodies substantially disposed in parallel and sharing
said first electrode matrix section.

US Pat. No. 10,188,854

MICROELECTRODE AND MULTIPLE MICROELECTRODES

NEURONANO AB, (SE)

1. An array of medical microelectrodes comprising at least two medical microelectrodes, each medical microelectrode of the at least two medical microelectrodes is configured for insertion into soft tissue, each medical microelectrode comprising:an electrically conducting elongate electrode body including a first proximal end, and a second distal end, the electrode body comprising:
a tip section extending from the distal end;
a main body section extending in a proximal direction from the tip section,
wherein the tip section and the main body section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid;
a dissolution retarding layer on the first electrode matrix element; and
a second electrode matrix section element, different from the first electrode matrix section element, the second electrode matrix section element positioned such that the first electrode matrix section element is positioned between the second electrode matrix section element and the electrode main body,
wherein at least one the first electrode matrix element and the second electrode matrix element comprises a drug configured to be released upon dissolution or biodegradation of the first electrode matrix element, and
wherein the at least two microelectrodes are positioned interspaced on a face of a solid support.

US Pat. No. 10,363,411

MICROELECTRODE AND MULTIPLE MICROELECTRODES

NEURONANO AB, (SE)

1. Medical microelectrode for insertion into soft tissue, comprising an electrically conducting elongate electrode body having a first, proximal end and a second, distal end, the electrode body comprising a tip section extending from its distal end, a main body section extending in a proximal direction from the tip section, and, optionally, a coupling section extending in a proximal direction from the main body section, wherein the tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid, further comprising one or both of:a dissolution retarding layer on the first electrode matrix element;
a second electrode matrix element disposed between the first electrode matrix element and the electrode;
wherein a drug capable of being released upon dissolution or biodegradation of the first electrode matrix element is comprised by the first electrode matrix element or the second electrode matrix element; and
an anchor positioned at the tip section.

US Pat. No. 10,315,027

MEDICAL MICROELECTRODE, METHOD FOR ITS MANUFACTURE, AND USE THEREOF

NEURONANO AB, (SE)

1. Proto microelectrode from which a micro electrode is formed in situ upon insertion of the proto microelectrode into soft tissue, comprising a flexible oblong electrode body of electrically conducting material having a front distal end and a rear proximal end, the electrode body comprising one or more of a metal or a metal alloy or an electrically conducting form of carbon or an electrically conducting polymer or a combination thereof, a first coating comprising one or more of a water soluble material and/or a swellable material and/or a degradable material on the electrode body and having a length that extends along the electrode body at least over a portion extending from its front end towards its rear end, and a second coating of electrically insulating, water insoluble flexible polymer material on the first coating and at least along the length of the first coating, the second coating comprising one or more through openings at or near its front end to permit the first coating to dissolve, swell, or degrade when the microelectrode is inserted into the soft tissue.