US Pat. No. 9,120,721

METHOD OF PREPARING CHIRAL KETONES FROM ALDEHYDES

Nanyang Technological Uni...

1. A method of preparing a chiral ?- or ?-substituted ketone from the corresponding ?- or ?-substituted aldehyde, wherein
the ketone has formula (I), (III) or (V),

and the corresponding aldehyde has formula (II), (IV) or (VI), respectively,

the method comprising reacting the aldehyde in the presence of an amine, oxygen and an organic solvent, wherein the reaction
is carried out in the absence of a metal-based catalyst or a metal-based oxidant,

wherein:
R is H, a substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C15 alkenyl, substituted or unsubstituted C2-C15 alkynyl, substituted or unsubstituted C3-C15 cycloalkyl, substituted or unsubstituted C3-C15 cycloalkenyl, substituted or unsubstituted C3-C15 heterocycloalkyl, substituted or unsubstituted C3-C15 heterocycloalkenyl, substituted or unsubstituted C6-C15 aryl, or substituted or unsubstituted C6-C15 heteroaryl; and

R? is H, a substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C15 alkenyl, substituted or unsubstituted C2-C15 alkynyl, substituted or unsubstituted C3-C15 cycloalkyl, substituted or unsubstituted C3-C15 cycloalkenyl, substituted or unsubstituted C3-C15 heterocycloalkyl, substituted or unsubstituted C3-C15 heterocycloalkenyl, substituted or unsubstituted C6-C15 aryl, or substituted or unsubstituted C6-C15 heteroaryl.

US Pat. No. 9,346,913

METHODS OF PREPARING MONODISPERSED POLYDOPAMINE NANO- OR MICROSPHERES, AND METHODS OF PREPARING NANO- OR MICROSTRUCTURES BASED ON THE POLYDOPAMINE NANO- OR MICROSPHERES

NANYANG TECHNOLOGICAL UNI...

1. A method of preparing monodispersed polydopamine nano- or microspheres, the method comprising:
a) providing a solvent system comprising water and at least one alcohol having the formula R—OH, wherein R is selected from
the group consisting of optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C3-C6 cycloalkenyl, and optionally substituted C6-C7 aryl;

b) adding dopamine to said solvent system to form a reaction mixture; and
c) agitating said reaction mixture for a time period of 1 to 10 days to form said monodispersed polydopamine nano- or microspheres.

US Pat. No. 9,441,301

METHOD FOR FORMING A BIMETALLIC CORE-SHELL NANOSTRUCTURE

Nanyang Technological Uni...

1. A method for forming a bimetallic core-shell nanostructure, wherein the core comprises silver and the shell comprises gold,
the method comprising forming a pure gold shell on a silver nanostructure core by simultaneously adding a gold precursor at
a flow rate of about 1 to 3 ml/h and a reducing agent at a flow rate of about 1 to 3 ml/h to a solution containing silver
nanoparticles, wherein the reducing agent comprises hydroxylamine solution or a hydroxylamine salt.

US Pat. No. 9,152,867

USE OF RELATIVELY PERMANENT PIGMENTED OR VASCULAR SKIN MARK PATTERNS IN IMAGES FOR PERSONAL IDENTIFICATION

Los Angeles Biomedical Re...

1. A method comprising:
point matching a first plurality of relatively permanent pigmented or vascular skin marks (RPPVSMs) in a first image with
a second plurality of RPPVSMs in a second image; and

determining a correspondence probability between the first plurality of RPPVSMs and the second plurality of RPPVSMs based
on using variables comprising: a size of overlapped total skin area of two images containing RPPVSMs, a distance threshold
between two RPPVSMs to be considered matching, and a number of matching RPPVSMs of the first and second images,

wherein one of the point matching or the determining is performed by a processor.

US Pat. No. 9,238,715

POLYMERIZABLE COMPOSITION FOR OPHTHALMIC AND MEDICAL USE AND ANTIMICROBIAL COMPOSITION OBTAINED BY POLYMERIZING THE POLYMERIZABLE COMPOSITION

Nanyang Technological Uni...

1. A composition comprising epsilon-polylysine having (meth)acryloyl group, wherein the (meth)acryloyl group is attached to
an amino group of the polylysine via an amide bond,
wherein the composition comprises:
(i) a hydrophilic monomer, wherein the hydrophilic monomer is selected from the group consisting of N-vinylpyrrolidone, hydroxyethyl
(meth)acrylate, hydroxypropyl (meth)acrylate, hydroxybutyl (meth)acrylate, polyethyleneglycol mono(meth)acrylate, polypropyleneglycol
mono(meth)acrylate, N,N-dimethylacrylamide (DMA), N,N-diethylacrylamide, N-(2-hydroxyethyl) acrylamide, N-isopropylacrylamide,
acryloylmorpholine, 1-methyl-3-methylene-2-pyrrolidone, 1-ethyl-3-methylene-2-pyrrolidone, 1-methyl-5-methylene-2-pyrrolidone,
1-ethyl-5-methylene-2-pyrrolidone, 5-methyl-3-methylene-2-pyrrolidone, and 5-ethyl-3-methylene-2-pyrrolidone, and wherein
the hydrophilic monomer can be used alone or two or more of these can be used in combination;

and/or
(ii) a crosslinkable monomer, wherein the crosslinkable monomer is selected from the group consisting of allyl(meth)acrylate,
vinyl(meth)acrylate, 4-vinylbenzyl(meth)acrylate, 3-vinylbenzyl(meth)acrylate, methacryloyloxyethyl acrylate, ethyleneglycol
di(meth)acrylate, diethyleneglycol di(meth)acrylate, diethyleneglycol diallyl ether, polyethyleneglycol di(meth)acrylate,
polypropyleneglycol di(meth)acrylate, butanediol dimethacrylate, and trimethylolpropane trimethacrylate, and wherein the crosslinkable
monomer can be used alone or a mixture of two or more of these compounds can be used.

US Pat. No. 9,079,137

METHOD AND APPARATUS FOR DETERMINING BIOFOULING OF A MEMBRANE

Nanyang Technological Uni...

1. A method of determining a state of biofouling of a membrane contained within a flow cell, the flow cell having at least
an outer surface coupled to one or more acoustic transducers, the method comprising the following steps:
introducing inorganic particles into the flow cell such that the inorganic particles form at least a part of a top surface
of a foulant layer on the membrane;

emitting acoustic waves towards the membrane using the one or more transducers;
detecting an acoustic signature of reflected sound waves, the acoustic signature comprising a profile of reflected sound waves
from the top surface and a profile of reflected waves from the membrane; and

determining, based on the detected acoustic signature, a state of biofouling of the membrane.
US Pat. No. 9,169,394

METHODS FOR DISPERSING CARBON NANOTUBES AND COMPOSITIONS USED FOR THE METHODS

NANYANG TECHNOLOGICAL UNI...

17. The method of claim 14, wherein the thermosetting resin is selected from the group consisting of a cyanate ester, epoxy, vinyl ester, polyimide,
bismaleimide, and a mixture thereof.

US Pat. No. 9,154,104

MINIATURIZED PASSIVE LOW PASS FILTER

Nanyang Technological Uni...

1. A low pass filter comprising:
a first dominant inductor having a first end and a second end;
a second dominant inductor having a first end and a second end, wherein the second end of the first dominant inductor is electrically
connected to the second end of the second dominant inductor;

a first capacitor electrically coupled between the first end of the first dominant inductor and the first end of the second
dominant inductor;

a first shunt capacitor electrically coupled between the first end of the first dominant inductor and a ground potential;
and

a second shunt capacitor electrically coupled between the first end of the second dominant inductor and the ground potential,
wherein the first dominant inductor and the second dominant inductor are further coupled by one or both of magnetic coupling
and parasitic mutual capacitive coupling.

US Pat. No. 9,502,090

MEMORY DEVICE INCLUDING A DOMAIN WALL AND FERROMAGNETIC DRIVER NANOWIRE

NANYANG TECHNOLOGICAL UNI...

1. A memory device comprising
a ferromagnetic data nanowire,
a ferromagnetic driver nanowire disposed parallel to the data nanowire,
a read element and/or a write element positioned adjacent the data nanowire,
wherein driving a domain wall in the driver nanowire remotely drives a domain wall in the data nanowire past the read element
and/or the write element.

US Pat. No. 9,420,957

SYSTEM AND METHOD FOR PREDICTING ACUTE CARDIOPULMONARY EVENTS AND SURVIVABILITY OF A PATIENT

SINGAPORE HEALTH SERVICES...

1. A patient survivability prediction system comprising:
a first input to receive a first set of parameters relating to heart rate variability data of a patient;
a second input to receive a second set of parameters relating to vital sign data of the patient;
a memory module to store the first set of parameters and the second set of parameters;
at least one processor coupled to the memory module and configured to analyze the first set of parameters and the second set
of parameters and output a prediction on the survivability of the patient over the next 72 hours based on the first set of
parameters and the second set of parameters; and

a display coupled to the at least one processor to display the prediction on the survivability of the patient over the next
72 hours.

US Pat. No. 9,410,542

ULTRASONIC FLUID PRESSURE GENERATOR

NANYANG TECHNOLOGICAL UNI...

1. An ultrasonic fluid pressure generator for generating high pressure head in a fluid, the ultrasonic fluid pressure generator
comprising:
a transducer comprising a piezoelectric actuator and a displacement amplifier, the displacement amplifier having a fluid channel
therethrough, the displacement amplifier being connected to the piezoelectric actuator at one end and having a free vibrating
tip at another end;

a reflecting condenser disposed at the vibrating tip of the displacement amplifier to form a gap between the vibrating tip
and a reflecting surface of the reflecting condenser; and

a casing configured for establishing a standing wave in the fluid contained within the casing, the transducer and the reflecting
condenser being at least in part within the casing,

wherein fluid is taken in through the vibrating tip into the fluid channel of the displacement amplifier, and
wherein the reflecting condenser is configured to moveably engage the casing for adjusting pressure magnitude in the fluid.

US Pat. No. 9,512,039

OLIGOCRYSTALLINE CERAMIC STRUCTURES FOR ENHANCED SHAPE MEMORY AND PSEUDOELASTIC EFFECTS

Massachusetts Institute o...

1. A mechanical structure comprising:
a crystalline ceramic material that is capable of undergoing a reversible martensitic transformation and forming martensitic
domains, during such martensitic transformation, that have an average elongated domain length; and the crystalline ceramic
material being configured as an oligocrystalline ceramic material structure having a total structural surface area that is
greater than a total grain boundary area in the oligocrystalline ceramic material structure, the oligocrystalline ceramic
material structure including an oligocrystalline ceramic structural feature having an extent that is less than the average
elongated domain length of the crystalline ceramic material.

US Pat. No. 9,199,000

CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES

Nanyang Technological Uni...

1. A quaternized chitosan derivative having the following formula
wherein R?and R?are independently selected from the group consisting of optionally substituted C1-C18alkyl, m is 2 or 3, n is 1 to 20.

US Pat. No. 9,108,114

TANGIBLE USER INTERFACE AND A SYSTEM THEREOF

NANYANG TECHNOLOGICAL UNI...

1. A tangible user interface (TUI) for use as part of a set of TUIs, the TUI comprising:
a plurality of faces wherein said plurality of faces form the outer surface of the TUI; and
a sensing system configured to detect, for each of said faces, whether another of the set of TUIs is within a predetermined
sensing distance from the face, and, for each face of the TUI for which the determination is positive, determine which face
of a corresponding opposing TUI is opposing that face of the TUI, and a relative orientation of that face of the TUI and the
opposing face of the corresponding opposing TUI, the relative orientation being a relative angular position about a line connecting
centers of the TUI and the corresponding opposing TUI;

wherein the sensing system comprises inductive-based sensors arranged to determine the relative orientation of that face of
the TUI and the opposing face of the corresponding opposing TUI, wherein the TUI produces an output based on the determination
of the relative orientation.

US Pat. No. 9,096,431

NANOPARTICLE DECORATED NANOSTRUCTURED MATERIAL AS ELECTRODE MATERIAL AND METHOD FOR OBTAINING THE SAME

Nanyang Technological Uni...

1. A network of individual nanostructures forming a nanostructured material, the network comprising nanoparticles bound to
surfaces of the individual nanostructures:
wherein all nanoparticles bound to the surfaces of the individual nanostructures have a maximal dimension of about 20 nm;
wherein each of the individual nanostructures comprises mesopores having a maximal dimension of between about 2 nm to about
50 nm on the surface of each of the individual nanostructures; and

wherein the nanoparticles are selected from the group consisting of noble metal nanoparticles, metal oxide nanoparticles and
mixtures thereof.

US Pat. No. 9,496,253

MINIATURE PASSIVE STRUCTURES, HIGH FREQUENCY ELECTROSTATIC DISCHARGE PROTECTION NETWORKS, AND HIGH FREQUENCY ELECTROSTATIC DISCHARGE PROTECTION SCHEMES

Nanyang Technological Uni...

1. A miniature passive structure for electrostatic discharge protection and input/output matching for a high frequency integrated
circuit, the structure comprising:
a transmission line for providing at least one electrostatic discharge path; and
a capacitor with a first end connected to the transmission line and a second end connected to ground;
wherein the transmission line comprises an unloaded transmission line.

US Pat. No. 9,428,392

METHODS OF ENRICHING DIFFERENT SPECIES OF CARBON NANOTUBES

NANYANG TECHNOLOGICAL UNI...

1. A method of enriching specific species of carbon nanotubes by exposing a composition of carbon nanotubes comprising semiconductor
carbon nanotubes and metallic carbon nanotubes to an azo compound, the azo compound having the chemical formula (I) or a salt
thereof
A?N=N?B?n  (I)

wherein
at each occurrence, A is an optionally substituted naphthalene; B is the same as A or different from A and is an optionally
substituted naphthalene; and

n is 2 or 3;
the method comprising
a) mixing the azo compound with a suspension comprising the composition of carbon nanotubes to form a mixture;
b) incubating the mixture to react the azo compound with the carbon nanotubes, whereby a supernatant enriched with semiconductor
carbon nanotubes and a precipitate enriched with metallic carbon nanotubes are formed in the mixture; and

c) separating the supernatant and the precipitate formed in the mixture.

US Pat. No. 9,478,835

INTEGRATED ELECTRODE ARCHITECTURES FOR ENERGY GENERATION AND STORAGE

Nanyang Technological Uni...

1. A hybrid device comprising:
an energy converting unit comprising a first electrode, a second electrode and an energy converting medium arranged between
the first electrode and the second electrode, wherein the energy conversion takes place between the first electrode and the
second electrode of the energy converting unit;

an energy charge storing unit comprising a first electrode, a second electrode and an electrolyte medium arranged between
the first electrode and the second electrode; wherein:

the energy charge is stored between the first and the second electrode of the energy charge storing unit;
the second electrode of the energy converting unit and the second electrode of the energy charge storing unit being a shared
electrode electrically connecting the energy converting unit and the energy charge storing unit;

materials of the shared electrode comprise a metal and a nanostructured material, with at least one dimension of the nanostructured
material being in the nanometer range;

the metal of the shared electrode forms a first layer;
the first layer forms one side of the shared electrode in direct contact with the energy converting medium of the energy converting
unit;

the nanostructured material forms a second layer arranged on the first layer; and
the second layer forms another side of the shared electrode in direct contact with the electrolyte medium of the energy charge
storing unit.

US Pat. No. 9,295,429

PREDICTING ACUTE CARDIOPULMONARY EVENTS AND SURVIVABILITY OF A PATIENT

SINGAPORE HEALTH SERVICES...

1. A method of producing an artificial neural network capable of predicting the survivability of a patient, the method comprising:
storing in an electronic database patient health data, the patient health data comprising a plurality of sets of data, each
set having a first parameter relating to heart rate variability data, a second parameter relating to vital sign data, a third
parameter relating to patient survivability, and a fourth parameter including at least one of ST segment elevation and depression;

providing a network of nodes interconnected to form an artificial neural network, the nodes comprising a plurality of artificial
neurons, each artificial neuron having at least one input with an associated weight; and

training the artificial neural network using the patient health data such that the associated weight of the at least one input
of each artificial neuron of the plurality of artificial neurons is adjusted in response to respective first, second, third,
and fourth parameters of different sets of data from the patient health data, such that the artificial neural network is trained
to produce a prediction on the survivability of a patient within the next 72 hours.

US Pat. No. 9,112,226

ANODE MATERIAL FOR ULTRAFAST-CHARGING LITHIUM ION BATTERIES AND A METHOD OF ITS SYNTHESIS

Nanyang Technological Uni...

1. An anode material for ultrafast-charging lithium ion batteries, the anode material comprising C—Li4Ti5O12 having a nanosheet structure.
US Pat. No. 9,079,824

METHOD FOR THE SYNTHESIS OF AN AMINO ACETAL

Nanyang Technological Uni...

1. A method for the synthesis of an ?-amino acetal, comprising
(i) oxidizing a tertiary amine in the presence of a copper catalyst, at least one oxidant and a solvent, or
(ii) reacting a secondary amine and an aliphatic aldehyde in the presence of a copper catalyst, at least one oxidant and a
solvent.

US Pat. No. 9,453,044

METHOD OF SYNTHESIZING PEPTIDES, PROTEINS AND BIOCONJUGATES

Nanyang Technological Uni...

1. A method of preparing a polypeptide or protein of formula (3)
comprising:
reacting a C-terminal salicylaldehyde ester peptide of formula (1)

with an aminoacyl-N-hydroxyl peptide of formula (2)

wherein the reaction is carried out in a pyridine/organic acid mixture to form an intermediate compound having a 1,2,5-oxadiazinane
ring structure; and

adding a reducing agent to cleave the 1,2,5-oxadiazinane ring structure of the intermediate compound to form the polypeptide
or protein of formula (3), wherein each of R1, R2 and R3 is independently selected from the group consisting of H, a substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C15 alkenyl, substituted or unsubstituted C2-C15 alkynyl, substituted or unsubstituted C3-C15 cycloalkyl, substituted or unsubstituted C3-C15 cycloalkenyl, substituted or unsubstituted C3-C15 heterocycloalkyl, substituted or unsubstituted C3-C15 heterocycloalkenyl, substituted or unsubstituted C6-C15 aryl, or substituted or unsubstituted C6-C15 heteroaryl, and a side chain of an amino acid; or

R1 is C1-C10 alkylyl that forms together with the nitrogen of the adjacent backbone imino group, a heteroalicyclic ring.

US Pat. No. 9,331,659

INTEGRATED CIRCUIT ARCHITECTURE WITH STRONGLY COUPLED LC TANKS

Nanyang Technological Uni...

1. An injection locked frequency divider having a predetermined frequency division ratio and comprising:
a primary LC tank circuit comprising a first inductor (L) and a first capacitive device (C) coupled in parallel; and
one or more secondary LC tank circuits, each comprising an inductor (L) and a capacitive device (C) coupled in parallel, wherein
each of the one or more secondary LC tank circuits is coupled to the primary LC tank circuit for band pass filtering an input
frequency to generate an output frequency filtered in accordance with the predetermined frequency division ratio;

wherein the predetermined frequency division ratio is based on a quantity of secondary LC tank circuits;
wherein the injection locked frequency divider is tunable through at least one of magnetic or electric coupling between the
primary LC tank circuit and the one or more secondary LC tank circuits.

US Pat. No. 9,415,379

METHOD OF SYNTHESIZING TUNGSTEN CARBIDE NANORODS AND CATALYSTS FORMED THEREWITH

NANYANG TECHNOLOGICAL UNI...

14. A catalyst of metal nanostructures supported on tungsten carbide nanorods, wherein each metal nanostructure is about 4
nm in average size, and wherein the tungsten carbide nanorods have a mesoporous nanorod structure comprising mesopores among
aggregated nanorods.

US Pat. No. 9,416,009

METHOD FOR MODIFYING ELECTRICAL PROPERTIES OF CARBON NANOTUBES

Nanyang Technological Uni...

1. A method for enriching specific species of carbon nanotubes according to their electronic properties and/or their diameter,
comprising modifying the electrical properties of carbon nanotubes by subjecting a composition of carbon nanotubes to one
or more radical initiator(s), wherein the modification is carried out in the presence of one or more alkene(s) or one or more
alkyne(s) or mixtures thereof to produce C—C radicals, wherein the alkene or alkyne is substituted with one or more electron-withdrawing
groups, and wherein the specific species of carbon nanotubes to be enriched comprises single-walled semiconducting carbon
nanotubes;
wherein the method comprises:
mixing the composition of carbon nanotubes with the one or more radical initiator(s) in an organic solvent or a mixture of
organic solvents to form a mixture, wherein the radical initiator is selected from the group consisting of organic peroxides,
inorganic initiators, halogen-containing compounds and mixtures thereof;

activating the one or more radical initiator(s) to form radicals;
reacting the carbon nanotubes with the radicals, wherein the radicals preferably react with those species of carbon nanotubes
different from the specific species of carbon nanotubes to be enriched; and

separating the modified carbon nanotubes from the unmodified carbon nanotubes, thereby enriching the specific species of carbon
nanotubes.

US Pat. No. 9,385,163

ADDRESSABLE SIOX MEMORY ARRAY WITH INCORPORATED DIODES

WILLIAM MARSH RICE UNIVER...

1. A resistive memory cell comprising:
a doped silicon layer positioned on a silicon substrate;
a first electrode;
a resistive memory material coupled to the first electrode, wherein the resistive memory material is selected from the group
consisting of SiOx, SiOxH, SiOxNy, SiOxNyH, SiOxCz, SiOxCzH, and combinations thereof, wherein each of x, y and z are equal to or greater than 1 and equal to or less than 2;

a diode coupled to the resistive memory material; and
a second electrode.

US Pat. No. 9,064,350

METHODS OF PROVIDING GRAPHICS DATA AND DISPLAYING

Nanyang Technological Uni...

1. A method of providing graphics data, comprising:
generating a first set of data vectors specifying geometrical characteristics of a graphical object in a first digital picture,
the first set of data vectors representing a first key digital picture frame,

generating a second set of data vectors specifying geometrical characteristics of the graphical object in a second digital
picture to be displayed after the first digital picture, the second set of data vectors representing a second key digital
picture frame,

generating a parameter set comprising information specifying intermediate geometrical characteristics of the graphical object
based on the geometrical characteristics of the graphical object in the first digital picture and based on the geometrical
characteristics of the graphical object in the second digital picture, wherein the intermediate geometrical characteristics
are geometrical characteristics of the graphical object in at least one third digital picture which is to be displayed after
the first digital picture and before the second digital picture,

generating at least one data file comprising the first set of data vectors, the second set of data vectors and the parameter
set, and

using predetermined definitions stored in a library file as vector information to represent the graphical object in the first
key digital picture frame and the second key digital picture frame in order to reduce the size of the at least one data file;
and

wherein the predetermined definitions include an enhanced disk B-spline curve represented by at least one control circle,
the control circle denoted by a position of a control point, a radius and a color parameter.

US Pat. No. 9,486,302

MULTI-LAYERED SURGICAL PROSTHESIS

NANYANG TECHNOLOGICAL UNI...

1. A method of manufacturing a prosthesis having a multi-layered sheet structure, comprising integrally forming at least two
continuous polymer film layers with no distinguished filaments or fibers within each layer, wherein the at least two continuous
polymer film layers are in continuous contact with each other to produce the multi-layered sheet structure, and wherein the
outermost layer of the multi-layered sheet structure is formed by casting the polymer on a roughened mold to obtain a roughed
surface, forming the additional layers thereon and, then, mechanically or chemically treating said roughed surface to increase
its surface friction and wetting ability.

US Pat. No. 9,362,445

LIGHT-EMITTING DEVICE

Nanyang Technological Uni...

1. A light emitting device comprising:
an electron injecting layer;
a hole injecting layer; and
an active layer sandwiched between the electron injecting layer and the hole injecting layer, wherein:
the hole injecting layer comprises a plurality of current spreading layers, the plurality of current spreading layers including
a first P doped layer, a first N doped layer and a second P doped layer, and

the first N doped layer has a doping level and thickness configured for substantial depletion or full depletion.

US Pat. No. 9,334,275

PROCESSES FOR PREPARING INDOLES

NANYANG TECHNOLOGICAL UNI...

1. A method for the synthesis of an indole of Formula (I) or a salt thereof,
the method comprising oxidizing a N-aryl imine of Formula (II)
in the presence of a palladium-based catalyst, an oxidant selected from the group consisting of copper (II) acetate, benzoquinone,
tert-butylhydroperoxide, di-tert-butyl peroxide (tBuOOtBu), tert-butyl benzoyl peroxide (BzOOtBu), molecular oxygen (O2), and air, or combinations thereof and a solvent comprising of dimethylsulfoxide, wherein the amount of oxidant is about
0.5 equivalence to about 5 equivalence of N-aryl amine;wherein
R1 at each occurrence is independently selected from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, optionally substituted C3-C20 mono-, or poly-cycloalkyl, optionally substituted 2-20-membered heteroalkyl, optionally substituted 3-20-membered mono-, or
poly-heterocycloalkyl, halogen, and —OR; wherein R is optionally substituted C1-C20 alkyl; wherein R2 is selected from the group consisting of optionally substituted C2-C20 alkenyl, optionally substituted 2-20-membered heteroalkenyl, optionally substituted monocyclic, condensed polycyclic or bridged
polycyclic C5-C20 aryl, and optionally substituted 5-20-membered monocyclic, condensed polycyclic or bridged polycyclic heteroaryl; wherein
R3 is selected from the group consisting of hydrogen, C1-C20 alkyl, C2-C20 alkenyl; monocyclic, condensed polycyclic or bridged polycyclic C5-C20 aryl; C3-C20 mono-, or poly-cycloalkyl; and C3-C20 mono-, or poly-cycloalkenyl;

m is 0, 1, 2, 3, or 4;wherein
R1 at each occurrence is positioned on the phenyl ring in 3-, 4-, 5-, or 6-position with respect to the bond linking the phenyl
to the —N—H group according to Formula (I) or the —N?C group according to Formula (II).

US Pat. No. 9,317,761

METHOD AND AN APPARATUS FOR DETERMINING VEIN PATTERNS FROM A COLOUR IMAGE

Nanyang Technological Uni...

1. A method of determining vein patterns from a colour image for personal identification, the method comprising:
forming a counterpart of the colour image by applying a functional relationship obtained from optimization on the colour image,
wherein the counterpart of the colour image comprises the vein patterns,

wherein the functional relationship is formulated using a model modelling colour image and a counterpart of the modelling
colour image, wherein the counterpart of the modelling colour image comprises modelling vein patterns.

US Pat. No. 9,293,654

LIGHT-EMITTING DEVICE

NANYANG TECHNOLOGICAL UNI...

1. A light emitting device comprising:
a hole injection layer,
an electron injection layer,
a composite emitter layer including a soft matter or soft material exciton donor matrix and exciton acceptor nanoparticles
substantially dispersed within the exciton donor matrix,

wherein the exciton donor matrix is a functionalised polymer, and wherein the nanoparticles have a loading of above 4% and
are bound with the functionalised polymer so that electrons from the electron injection layer and holes from the hole injection
layer generate excitons in the exciton donor matrix, and the primary mechanism of photon generation at the nanoparticles is
substantially non-radiative energy transfer of the generated excitons directly into the nanoparticles.

US Pat. No. 9,199,734

MOTORISED DEVICE AND METHOD OF MOVING THE DEVICE

NANYANG TECHNOLOGICAL UNI...

1. A motorized device arranged to move using cyclic motion, the device comprising:
at least two DC motors;
at least one limb coupled to the at least two DC motors, and configured to be driven by the at least two DC motors for moving
the device; and

a resilient biaser coupled to the at least one limb and configured to further drive the at least one limb using mechanical
resonance configured to occur at a flapping frequency of the at least one limb.

US Pat. No. 9,119,569

METHOD AND APPARATUS FOR CALIBRATING A MOTION TRACKING SYSTEM

Nanyang Technological Uni...

1. A method of calibrating a motion tracking system comprising a plurality of orientation sensors attachable to a plurality
of body segments of a user, the plurality of orientation sensors being communicatively coupled to a computer, the method comprising
the steps of:
receiving, at the computer, a first set of orientation signals from a first set of the orientation sensors, the first set
of orientation signals associated with a first pair of the body segments matching a first set of predetermined positions,
wherein the first pair of the body segments comprise corresponding body segments on different sides of the body of the user;

calibrating, by the computer, the skeleton dimension of the user and a mapping between the body segments and the corresponding
attached sensors based on the first set of orientation signals, wherein calibrating the mapping comprises determining, by
the computer for each sensor of the first set of the orientation sensors, a body segment of the plurality of body segments
associated with the sensor,

wherein calibrating the skeletal dimensions of the user further comprises the steps of:
calculating, by the computer, from the first set of predetermined positions a corresponding set of step vectors between the
first pair of body segments;

calculating, by the computer, lower body skeleton dimension parameters by solving a kinematic chain equation based on the
step vectors and the corresponding orientation signals.

US Pat. No. 9,505,718

3-PIPERIDONE COMPOUNDS AND THEIR USE AS NEUROKININ-1 (NK1) RECEPTOR ANTAGONISTS

Nanyang Technological Uni...

1. Method for synthesizing a compound of Formula (II)
wherein
R1 is a nitrogen-protecting group derivable from an amino group selected from the group consisting of tosylamide (Ts), t-butyl
carbamate (Boc), benzyl carbamate (Cbz), 9-fluorenylmethyl carbamate (Fmoc), acetamide (Ac), trifluoroacetamide (TFA), benzylideneamine,
triphenylmethylamine (Tritylamine), benzylamine (Bn), and phthalimide;

R2 is selected from the group consisting of halogen, —C(O)—R, —NRR?, —OR, —SR, —COOR, —CN, —NO2, —C(O)—NRR?, —NR?—C(O)—R, —SO2—R, —(SO2)—OR, linear or branched, substituted or unsubstituted C1-C10 alkyl; linear or branched, substituted or unsubstituted C2-C10 alkenyl; linear or branched, substituted or unsubstituted C2-C10 alkynyl; linear or branched, substituted or unsubstituted C1-C10 alkoxy; substituted or unsubstituted C3-C10 cycloalkyl; substituted or unsubstituted C3-C10 cycloalkenyl; substituted or unsubstituted C6-C10 aryl; substituted or unsubstituted C3-C10 heteroaryl;

R and R? are independently selected from the group consisting of H and linear or branched, substituted or unsubstituted C1-C10 alkyl;
the method comprising:
reacting a compound of Formula (I)

with NH2R1 to form a compound of Formula (IV)


reacting the compound of Formula (IV) with a precursor of R2 in the presence of a rhodium catalyst to form an enantiomer of a compound of Formula (V)


reacting the compound of Formula (V) with an oxidizing agent to form a compound of Formula (VI)

reacting the compound of Formula (VI) with a reducing agent to form a compound of Formula (VII)
and
hydrogenating the compound of Formula (VII) to form the compound of Formula (II).

US Pat. No. 9,375,554

BALLOON INFLATING DEVICE AND A METHOD FOR INFLATING A BALLOON

NATIONAL UNIVERSITY OF SI...

1. An intragastric balloon system comprising:
a swallowable device comprising:
an elastic balloon;
a first substance within the balloon;
a second substance within the balloon capable of reacting with the first substance within the balloon to generate a gas to
inflate the balloon;

a casing attached to or disposed within the balloon, the casing carrying a passage through which the gas can flow from the
interior of the balloon to an environment external to the casing;

a battery disposed within the casing;
a microcontroller disposed within the casing and coupled to the battery; and
an electrical activator carried by the casing, the electrical activator controllable by the microcontroller;
wherein the electrical activator comprises a syringe having a plunger and an actuator configured to drive the plunger, wherein
the syringe contains the first substance and the actuator is configured to, when activated electrically, drive the plunger
forward and actuate the first substance to contact the second substance to generate the gas, and

wherein the syringe carries an opening connecting to the passage to transfer the gas to the environment external to the casing
and the opening is exposed to the generated gas by retracting the forwardly driven plunger backward to deflate the elastic
balloon inflated by the generated gas.

US Pat. No. 9,370,767

METAL OXIDE COMPOSITE AND A METHOD OF FORMING THEREOF

NANYANG TECHNOLOGICAL UNI...

1. A method of forming a metal oxide composite in the form of beads, the method comprising:
mixing a metal oxide, at least two monomers and a dispersant to produce a slurry;
gel casting the slurry to produce a green metal oxide composite; wherein the gel casting comprises dropping the slurry into
a gel casting media to form the green metal oxide composite as beads; and

sintering the green metal oxide composite to produce the metal oxide composite in the form of beads;
wherein the gel casting media comprises a graphite-oil media; and
wherein the metal oxide comprises at least one of: a cobalt-based metal oxide, a yttria stabilized zirconia-based metal oxide,
a nickel-based metal oxide, and a perovskite-based metal oxide.

US Pat. No. 9,337,157

MINIATURE PASSIVE STRUCTURES FOR ESD PROTECTION AND INPUT AND OUTPUT MATCHING

Nanyang Technological Uni...

1. A miniature passive structure for electrostatic discharge (ESD) protection and input/output (I/O) matching for a high frequency
integrated circuit, the structure comprising:
at least one shunt stub for providing a corresponding at least one ESD discharge path; and
at least one load line having a first end open-ended and a second end connected to the ground, wherein the at least one load
line is coupled to the at least one shunt stub and provides loading effects for the at least one shunt stub.

US Pat. No. 9,431,599

NON-VOLATILE LOGIC DEVICE

NANYANG TECHNOLOGICAL UNI...

1. A non-volatile logic device, comprising:
a first input element which is magnetizable along a first direction of magnetization to impart or change a chirality of a
domain wall traversing the first input element, the chirality representing a first logical input;

a second input element joined to the first input element to transport the domain wall, the second input element being magnetizable
along a second direction of magnetization which is orthogonal to the first direction of magnetization, a magnetization of
the second input element along the second direction of magnetization representing a second logical input;

a bifurcated output section connected to the second input element at a junction, the output section comprising a pair of output
elements for selectively receiving the domain wall from the second input element, a magnetization of at least part of the
respective output elements being changeable by propagation of the domain wall along the respective output elements; and

a non-magnetic conductive element disposed in partially overlapping relationship with the second input element at or near
the junction;

wherein the magnetization in an output element after propagation of the domain wall represents a value of a logical function
of the first logical input and/or the second logical input, or a logical complement of the value; and

wherein the logical function is selectable by passing an electrical current through the non-magnetic conductive element to
induce a magnetic field of a desired magnitude and direction in the second input element.

US Pat. No. 9,376,676

METHOD OF BREAKING DOWN BIOLOGICAL MATERIAL

Agency for Science, Techn...

1. A method of breaking down biological material, the method comprising:
providing a sample into a channel disposed on a substrate, the sample comprising the biological material in a liquid;
providing a gas into the channel such that the gas forms an interface with the liquid; and
exciting a transducer attached to the substrate to generate and apply acoustic waves in a plurality of sequential bursts to
the interface to break down the biological material.

US Pat. No. 9,373,876

MULTIPLE-MODE FILTER FOR RADIO FREQUENCY INTEGRATED CIRCUITS

Nanyang Technological Uni...

16. A bandpass filter comprising:
a first filtering circuit; and
one or more second filtering circuits, wherein each of the first and one or more second filtering circuits are cascaded through
input and output ports thereof up to N stages, wherein N is an integer greater than one, to define parameters that are designed
to meet a predetermined filtering response, and wherein each of the first and one or more second filtering circuits comprises:

a first set of filter coupled elements;
a second set of filter coupled elements;
a three-port “T” transmission line junction having a first port coupled to a first end of a first one of the first set of
filter coupled elements and a second port coupled to a first end of a first one of the second set of filter coupled elements,
wherein a second one of the first set of filter coupled elements comprises an input transmission line having an end thereof
coupled to an input port and an opposite end thereof comprising an open end, and wherein a second one of the second set of
filter coupled elements comprises an output transmission line having an end thereof coupled to an output port and an opposite
end thereof comprising an open end; and

a perturbing element coupled to a third port of the three-port “T” transmission line junction,
wherein at least one of the first and one or more second filtering circuits is configured as an elliptical multimode filter,
wherein the open end of the input transmission line and the open end of the output transmission line are each connected with
a section of coupled lines wherein an end section of the coupled lines that is opposite the section of the coupled lines connected
to the input and output transmission lines is connected to ground.

US Pat. No. 9,334,230

PROCESS OF FORMING AN AMIDE

NANYANG TECHNOLOGICAL UNI...

1. A process of forming an amide, the process comprising:
providing a Ruthenium (II) catalyst, the Ruthenium (II) catalyst being free of a phosphine ligand, wherein providing the Ruthenium
(II) catalyst comprises:

providing an N-heterocyclic carbene formed from an imidazole or an imidazoline compound and a base, wherein the imidazole
compound is of general formula (I) and the imidazoline compound is of general formula (II):


wherein R5-R8 are independently H, alkyl or aryl; and

contacting the N-heterocyclic carbene with a [Ru(A)Cl2]2 precatalyst complex, wherein A in [Ru(A)Cl2]2 is a benzene based moiety of general formula (III)


wherein R9-R14 are independently H, alkyl, or aryl; and

contacting in the presence of the Ruthenium (II) catalyst a primary or a secondary amine and a primary alcohol, wherein the
primary or secondary amine and the primary alcohol are (i) a primary or secondary amine moiety of a first reactant and a primary
alcohol moiety of a second reactant, or (ii) a first moiety, being a primary or secondary amine, and a second moiety, being
a primary alcohol, of the same compound,

wherein the process is carried out without adding a phosphine.

US Pat. No. 9,130,511

POWER AMPLIFIER AND LINEARIZATION TECHNIQUES USING ACTIVE AND PASSIVE DEVICES

Nanyang Technological Uni...

1. A power amplifier comprising:
a first passive device for input matching and network biasing;
an active amplifying device having parameters tuned to predetermined harmonic frequencies;
a second passive device for suppression of harmonic frequencies other than the predetermined harmonic frequencies; and
a third passive device for output matching and network biasing; and
a loaded linearization stub coupled to the active amplifying device, wherein the loaded linearization stub comprises one or
more cascaded unit elements operating at one or more of the predetermined harmonic frequencies and different orders of the
predetermined harmonic frequencies.

US Pat. No. 9,522,843

APPARATUS AND METHOD FOR FABRICATING MICROCONTAINERS

NANYANG TECHNOLOGICAL UNI...

7. A method of fabricating microcontainers, the method comprising the steps of:
etching a plurality of hollow glass beads in a solution of an etching agent in a reaction zone of a mixer;
separating etched hollow glass beads from intact hollow glass beads in a sinking zone of the mixer by allowing the etched
hollow glass beads to sink in the solution; and

collecting the etched hollow glass beads in a collection zone of the mixer while minimizing etching in the collection zone.

US Pat. No. 9,082,984

METHOD FOR DISPERSING CARBON NANOTUBES USING CHONDROITIN SULFATE CATION SALT

NANYANG TECHNOLOGICAL UNI...

1. A method for dispersing carbon nanotubes, comprising:
(a) providing a solution containing chondroitin sulfate cation salt of formula (I)
wherein
R1 is H and R2 is MSO3;

M is an alkaline metal, or an alkaline earth metal further bound to a monovalent counter-anion;
n is at least 20; and
(b) contacting the carbon nanotubes with the solution containing the chondroitin sulfate cation salt, wherein the chondroitin
sulfate cation salt is an A or C isomer.

US Pat. No. 9,522,521

APPARATUS AND METHOD FOR SEPARATING A STACKED ARRANGEMENT

Nanyang Technological Uni...

1. An apparatus for separating a stacked arrangement comprising a first layer, a second layer and a release layer between
the first layer and the second layer, the apparatus comprising:
an attachment surface configured to suspend the stacked arrangement by attaching to the first layer, wherein the attachment
surface comprises a flexible plate;

an actuating mechanism configured to form a curvature of the first layer by bending the attachment surface; and
a holder configured to hold an etchant for etching the release layer to separate the first layer from the second layer.

US Pat. No. 9,324,159

METHOD AND SYSTEM FOR TRACKING MOTION OF A DEVICE

Nanyang Technological Uni...

1. A method for tracking the motion of a device across a surface, the method comprising repeatedly performing the following
steps (a)-(d):
(a) acquiring, using an image sensor of the device, an input image showing an input area, the input area being a portion of
the surface which is in the field of view of the image sensor;

(b) comparing the input image to a plurality of current reference images showing respective current reference areas of the
surface to estimate the displacement between the input area and each current reference area, wherein the plurality of current
reference images comprise previously acquired images;

(c) determining whether to update each individual current reference image based on the displacements estimated in step (b),
and if said determination is positive for an individual current reference image, updating the individual current reference
image to form an updated reference image; and

(d) determining, based on the displacements, the motion of the device across the surface from an area shown in a previously
acquired image to the input area;

wherein prior to step (d) in each repetition of steps (a)-(d), the method further comprises improving one or more of the displacements
estimated in step (b) by:

(i) determining the displacement between each current reference area and each of the other current reference areas using the
current reference images;

(ii) determining improved estimates of the displacements estimated in step (b), by minimizing a function of differences between
the displacements determined in step (i) and corresponding displacements determined with the improved estimates; and

(iii) improving the one or more of the displacements by setting these displacements as their respective improved estimates.
US Pat. No. 9,381,163

FLOATING CAPSULES ENCAPSULATING PARTICLES LOADED WITH ONE OR MORE DRUGS

NANYANG TECHNOLOGICAL UNI...

1. A method for forming a floating capsule encapsulating particles (S) loaded with one or more drugs, comprising:
suspending the particles (S) in an aqueous phase (W1) to form a S/W1 phase;
contacting the S/W1 phase with a solution of a polymer (O) in a first organic solvent to form a S/W1/O phase;
adding a water-immiscible oil with a density lower than water to the S/W1/O phase;
combining the S/W1/O phase including the water-immiscible oil with a water bath (W2) comprising a surfactant and a second
organic solvent and emulsifying the resulting mixture to form a S/W1/O/W2 phase; and

evaporating under reduced pressure the organic solvents in the S/W1/O/W2 phase to obtain the capsule.

US Pat. No. 9,327,217

MULTILAYER FILTER

NANYANG TECHNOLOGICAL UNI...

14. A method of preparing a filter comprising the steps of:
(i) fabricating a first layer comprising a plurality of openings;
(ii) fabricating at least a separate second permeable layer comprising a configuration;
(iii) positioning the second layer to overlay the first layer, wherein the configuration of the second layer reduces the size
of the openings, and wherein the configuration of the second layer comprises an array of strips partitioning the openings.

US Pat. No. 9,244,202

MICROLENS ARRAY AND A METHOD OF FABRICATING THEREOF

NANYANG TECHNOLOGICAL UNI...

1. A method of fabricating a microlens array, the method comprising the steps of:
compressing a shape memory polymer substrate with a predetermined load;
indenting the shape memory polymer substrate to form an array of micro-indents;
immersing the shape memory polymer substrate in a solvent causing stress-enhanced swelling in the shape memory polymer substrate
such that the array of micro-indents forms a corresponding array of micro-protrusions on the shape memory polymer substrate
due to the stress-enhanced swelling of the micro-indents; and

heating the shape memory polymer substrate to form at least one curved surface of the shape memory polymer substrate under
the micro-protrusion array.

US Pat. No. 9,357,282

LISTENING DEVICE AND ACCOMPANYING SIGNAL PROCESSING METHOD

Nanyang Technological Uni...

1. A listening device (120; 220; 320) for wearing by a user, comprising:
at least one support structure (112; 226; 330) for positioning on or adjacent both ears (2) of the user;

said at least one support structure including, for each ear, one or more corresponding first sound emitters (116; 216; 316) and one or more corresponding second sound emitters (118, 218; 330);

characterised in that when the listening device is worn by the user, the first and second sound emitters (116, 118; 216; 218; 316; 330) are positioned such that, for each ear:

the one or more corresponding first sound emitters (116; 216; 316) direct sound in a different direction from the one or more corresponding second sound emitters (118, 218; 330); and

a center of the one or more corresponding first sound emitters (116; 216; 316) is positioned to the anterior of the ear canal to emit sound in a posterior direction which is at an angle of at least 60
degrees to the axis of an ear canal of a user to direct sound at a wall portion of the concha of the ear.

US Pat. No. 9,322,643

APPARATUS AND METHOD FOR 3D SURFACE MEASUREMENT

NANYANG TECHNOLOGICAL UNI...

1. An apparatus for 3D surface measurement of a target surface, the apparatus comprising:
only two projectors, the two projectors comprising, a first projector configured to project a fringe pattern onto the target
surface and;

a second projector configured to project a fringe pattern onto the target surface;
only two cameras, the two cameras comprising, a first camera configured to capture the fringe patterns projected by the first
projector and the second projector and;

a second camera configured to capture the fringe patterns projected by the first projector and the second projector;
wherein the first projector, the second projector, the first camera and the second camera are calibrated with a same global
coordinates,

wherein the first projector and the first camera form a first optical 3D sensor configured to capture a first fringe pattern,
wherein the second projector and the first camera form a second optical 3D sensor configured to capture a second fringe pattern,
wherein the first projector and the second camera form a third optical 3D sensor configured to capture a third fringe pattern,
and wherein the second projector and the second camera form a fourth optical 3D sensor configured to capture a fourth fringe
pattern; and

a computer configured to:
perform fringe pattern processing of the first fringe pattern to generate a first 3D point cloud,
perform fringe pattern processing of the second fringe pattern to generate a second 3D point cloud,
perform fringe pattern processing of the third fringe pattern to generate a third 3D point cloud,
perform fringe pattern processing of the fourth fringe pattern to generate a fourth 3D point cloud, and
perform data stitching and merging of the first 3D point cloud, the second 3D point cloud, the third 3D point cloud, and the
fourth 3D point cloud to obtain a 3D surface reconstruction using the calibration with the same global coordinates.

US Pat. No. 9,291,547

IMMERSION REFRACTOMETER

Nanyang Technological Uni...

1. An immersion refractometer comprising:
a microchamber having an inlet and an outlet for allowing a sample containing microorganism particles to flow therethrough,
wherein the microchamber comprises at least one trapping site for trapping a microorganism particle in each respective trapping
site; and

a micromixer for mixing a plurality of liquids to form an external medium, wherein the micromixer and the microchamber are
in direct fluid connection to introduce the external medium into the microchamber for immersing the trapped microorganism
particle in the external medium.

US Pat. No. 9,603,190

INTEGRATED CIRCUIT ADAPTED FOR MOBILE COMMUNICATION AND RELATED MOBILE COMPUTING DEVICE

MASSACHUSETTS INSTITUTE O...

1. An integrated circuit adapted for mobile communication, comprising:
a first device layer formed of a first semiconductor material and having at least a first circuit portion; and
a second device layer formed of a second semiconductor material different to the first semiconductor material and having at
least a second circuit portion,

wherein the first and second device layers are integrally formed, and the first circuit portion is electrically coupled to
the second circuit portion to enable the mobile communication using first and second wireless communication protocols,

wherein the first circuit portion further includes a transceiver and a digital baseband processor, and wherein the digital
baseband processor is configured to adaptively operate between first and second clock frequencies, the first clock frequency
used when the circuit is configured to perform communication via the first wireless communication protocol, and the second
clock frequency used when the circuit is configured to perform communication via the second wireless communication protocol.

US Pat. No. 9,309,278

METHOD FOR MODIFICATION OF ORGANIC MOLECULES

Nanyang Technological Uni...

1. A method of alkylating a thiol group or a seleno group in a target molecule, the method comprising:
a thiol-ene reaction comprising reacting said thiol or seleno group with a compound of formula (I) or (II):

Wherein:
R is an acetyl group, an acyl group (other than acetyl), a poly(ethylene glycol)-containing acyl group (“PEG-containing acyl
group”) or is selected from the group consisting of:


R1 is an alkyl group, an acyl group, PEG, or a PEG-containing acyl group;
and
R? is selected from the group consisting of a hydrogen, a methyl group and an ethyl group.

US Pat. No. 9,301,329

APPARATUS, A METHOD AND A COMPUTER PROGRAM FOR INTERCONNECTING MULTIPLE COMPUTER NETWORKS

Nanyang Technological Uni...

1. An apparatus for interconnecting multiple computer networks, each computer network using a different protocol suite and
comprising multiple nodes, the apparatus being a node of each computer network, the apparatus comprising:
a transceiver configured to receive data from any node of any one of the multiple computer networks, the received data being
for transmission to a node of a different one of the multiple computer networks;

a memory configured to store information relating to the multiple computer networks; and
a processor configured, with the transceiver, to join the apparatus to computer networks which are in range of the transceiver
and which use one of a plurality of different protocol suites, wherein the apparatus is configured to communicate according
to the plurality of different protocol suites;

wherein the processor is configured, with the transceiver, to discover nodes of the multiple computer networks and to update
the information stored on the memory with details of the discovered nodes;

wherein the details of the discovered nodes comprises information on protocol suites of the computer networks of the discovered
nodes;

wherein the processor is further configured to identify the node of the different one of the multiple computer networks based
on the received data, to determine the protocol suite of the different one of the multiple computer networks based on the
updated information on the memory, to process the received data so that the received data appears to have been transmitted
according to the determined protocol suite, and to cause the transceiver to transmit the processed received data to the node
of the different one of the multiple computer networks.

US Pat. No. 9,586,884

METAL-DOPED HYDROXYAPATITE CATALYST

Agency for Science, Techn...

1. A method for converting an alcohol to an aldehyde, the method comprising:
contacting an alcohol with a doped hydroxyapatite as a catalyst to form an aldehyde,
wherein the doped hydroxyapatite has been doped with a dopant selected from the group consisting of a metal, a metal oxide,
and mixtures thereof, wherein the metal is a transition metal selected from the group consisting of group 5 transition metals,
group 11 transition metals, and chromium.

US Pat. No. 9,512,155

CHIRAL PHOSPHINES FOR PALLADIUM-CATALYZED ASYMMETRIC ?-ARYLATION OF ESTER ENOLATES TO PRODUCE TERTIARY STEREOCENTERS IN HIGH ENANTIOSELECTIVITY

NANYANG TECHNOLOGICAL UNI...

1. A method of asymmetrically synthesizing an ?-aryl compound of Formula I:

or a pharmaceutically acceptable salt thereof, the method comprising the step of reacting a compound of Formula II with a
compound of Formula III in the presence of a palladium catalyst, an activator, a compound of Formula IV, and optionally a
solvent, to produce the asymmetric ?-aryl compound of Formula I:


wherein:
* is an asymmetric carbon atom;
the compound of Formula III is the (E)- or (Z)—OSiR7R8R9 isomer;

the palladium catalyst is selected from PdMe2(TMEDA), Pd(dba)7, and Pd(OAc)2;

the solvent is an aromatic solvent;
Ar is a substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl group, which is optionally independently
substituted with 1, 2 or 3 R4 groups;

is a single or double bond, wherein either all of the are single bonds or all of the are double bonds;
R1 is independently selected from hydrogen, alkyl, aryl, and arylalkyl;

R2 and R3 are each independently selected from alkyl, cycloalkyl, aryl and arylalkyl;

each R4 is independently selected from hydrogen, amino, halogen, hydroxyl, nitro, cyano, alkyl, alkenyl, alkynyl, perfluoroalkyl,
cycloalkyl, alkoxy, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, (CH2)jOR11, (CH2)jC(O)R11, (CH2)jC(O)OR11, (CH2)jOC(O)R11, (CH2)jNR12R13, (CH2)jC(O)NR12R13, (CH2)jOC(O)NR12R13, (CH2)jNR14C(O)R11, (CH2)jNR14C(O)OR11, (CH2)jNR14C(O)NR12R13, (CH2)jS(O)mR11, and (CH2)jS(O)mNR12R13, wherein each j is independently an integer selected from 0 to 6, and each m is independently an integer selected from 0
to 2;

R5 is independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted heterocycloalkyl, substituted
or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, and substituted or
unsubstituted heteroarylalkyl, which is optionally independently substituted with 1, 2 or 3 R10 groups;

R6 is independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted
or unsubstituted aryl, and substituted or unsubstituted arylalkyl, which is optionally independently substituted with 1, 2
or 3 R10 groups;

R7, R8 and R9 are each independently selected from alkyl, aryl and arylalkyl;

each R10 is independently selected from hydrogen, amino, halogen, hydroxyl, nitro, cyano, alkyl, alkenyl, alkynyl, perfluoroalkyl,
cycloalkyl, alkoxy, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, (CH2)jOR11, (CH2)jC(O)R11, (CH2)jC(O)OR11, (CH2)jOC(O)R11, (CH2)jNR12R13, (CH2)jC(O)NR12R13, (CH2)jOC(O)NR12R13, (CH2)jNR14C(O)R11, (CH2)jNR14C(O)OR11, (CH2)jNR14C(O)NR12R13, (CH2)j S(O)mR11, and (CH2)jS(O)mNR12R13, wherein each j is independently an integer selected from 0 to 6, and each m is independently an integer selected from 0
to 2;

R11 is independently selected from hydrogen, alkyl, alkenyl, alkynyl, perfluoroalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl,
heteroaryl, and heteroarylalkyl; and

R12, R13, R14 are each independently selected from hydrogen, alkyl, alkenyl, alkynyl, perfluoroalkyl, cycloalkyl, heterocycloalkyl, aryl,
arylalkyl, heteroaryl, and heteroarylalkyl, or R14 is as described above, and R12 and R13 are joined together with the nitrogen atom to which they are attached, to form a substituted or unsubstituted 3- to 7-membered
hetercycloalkyl or substituted or unsubstituted 5-membered heteroaryl, wherein the 3- to 7-membered hetercycloalkyl is selected
from aziridine, azetidine, pyrrolidinyl, pyrazolidinyl, imidazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl,
and azepanyl; and the 5-membered heteroaryl is selected from pyrrolyl, pyrazolyl, imidazolyl, pyridinyl, pyrazinyl, pyrimidinyl,
indolyl, purinyl, benzimidazolyl, quinolinyl, and isoquinolinyl.

US Pat. No. 9,476,087

METHODS AND COMPOUNDS FOR DETECTING BETA-LACTAMASE ACTIVITY

NANYANG TECHNOLOGICAL UNI...

1. A compound of one of general formula (I):

general formula (II):

general formula (III):

general formula (VII):

general formula (VIII):

and general formula (IX):

wherein R1 is selected from the group consisting of H, halogen and


wherein X is one of O, S, Se and NH,
and R11 and R12 are independently from each other H or selected from the group consisting of an aliphatic group, an alicyclic group, an aromatic
group, an arylaliphatic group, and an arylalicyclic group, comprising 0 to about 3 heteroatoms selected from the group consisting
of N, O, S, Se and Si;

R2 is one of H, halogen, an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic group and an arylalicyclic
group, comprising 0 to about 3 heteroatoms selected from the group consisting of N, O, S, Se and Si;

R3 to R5, in formulas (I), (III), (VII) and (IX) R6, in formulas (VII)-(IX) R8 and R9, and in formulas (III) and (IX) R10, are independently from each other selected H or one of an aliphatic group, an alicyclic group, an aromatic group, an arylaliphatic
group and an arylalicyclic group, comprising 0 to about 3 heteroatoms selected from the group consisting of N, O, S, Se and
Si;

R15 in formula (I), R16 in formula (II) and R17 in formula (III) are independently selected from H or one of an aliphatic group, an alicyclic group, an aromatic group, an
arylaliphatic group and an arylalicyclic group, including 0 to about 5 heteroatoms selected from the group consisting of N,
O, S, Se and Si;

X is one of O, S, Se and NH;
E is one of S, SO, SO2, and CH2;

Z is S or Se; and
A in formulas (I)-(III) and G in formulas (VII)-(IX) are independently from each other a bridge selected from an aliphatic,
alicyclic, aromatic, arylaliphatic, and arylalicyclic radical with a main chain of 1-50 carbon atoms and 0-50 heteroatoms;

with the proviso that, where in formula (I) R15 is


from the bridge A of the compounds of formulas (I) and (II) the following group is excluded:

US Pat. No. 9,389,160

CAVITATION SENSOR

Nanyang Technological Uni...

1. A cavitation sensor for detecting bubbles in a liquid, the cavitation sensor comprising:
a substrate having an insulative surface; and
an electrode arrangement provided on or within the insulative surface of the substrate; wherein the electrode arrangement
comprises a first electrode and a second electrode being isolated from each other by the insulative surface, each of the first
and the second electrode comprising a sensing portion, wherein a spacing between the sensing portion of the first electrode
and the sensing portion of the second electrode is adapted to allow charge flow between the first electrode and the second
electrode caused by cavitation occurring at the sensing portion;

wherein the sensing portion of the first electrode and the sensing portion of the second electrode are configured to remain
stationary relative to the substrate, to detect a change in a velocity of liquid flowing parallel to the substrate surface
where the electrode arrangement is provided on.

US Pat. No. 9,324,512

SPST SWITCH, SPDT SWITCH, SPMT SWITCH AND COMMUNICATION DEVICE USING THE SAME

Nanyang Technological Uni...

1. A single pole double throw switch, comprising:
a first terminal, a second terminal and a third terminal;
a first control terminal and a second control terminal;
a first field-effect transistor having a drain connected to the first terminal, a source connected to a ground, and a gate;
a first bias resistor connected between the gate of the first field-effect transistor and the first control terminal;
a first inductor connected between the first terminal and the second terminal;
a second field-effect transistor having a drain connected to the third terminal, a source connected to the ground, and a gate;
a second bias resistor connected between the gate of the second field-effect transistor and the second control terminal;
a second inductor connected between the second terminal and the third terminal; and
a capacitor having one end connected to the second terminal and another end connected to the ground;
wherein the first field-effect transistor and the second field-effect transistor have respective widths based on a target
isolation of the single pole double throw switch;

wherein each of the first and the second field-effect transistors has a switched-on state exhibiting an on-resistance and
a switched-off state exhibiting an off-capacitance;

wherein the single pole double throw switch is configured to form a ?-impedance-matching network by the first inductor, the
capacitor and the first field-effect transistor exhibiting the off-capacitance, or to form the ?-impedance-matching network
by the second inductor, the capacitor and the second field-effect transistor exhibiting the off-capacitance, wherein:

the width of the first field-effect transistor is equal to

the width of the second field-effect transistor is equal to


ISO denotes the target isolation of the single pole double throw switch,
Z0 denotes a characteristic impedance,

ron,1 denotes an on-resistance per unit transistor width of the first field-effect transistor, and

ron,2 denotes an on-resistance per unit transistor width of the second field-effect transistor.

US Pat. No. 9,206,090

TRICYCLIC CHIRAL COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYSIS

NANYANG TECHNOLOGICAL UNI...

1. A hexahydropyrrolo[2,3-b]indole compound of Formula (XX)

wherein R is —COOR3,
wherein R3 is selected from one of hydrogen, an aliphatic group with a main chain having 1 to about 20 carbon atoms, an alicyclic group,
an aromatic group, an arylaliphatic group and an arylalicyclic group, comprising 0 to about 3 heteroatoms independently selected
from the group consisting of N, O, S, Se and Si,
R31 is hydrogen;

R30 is one of —C(OH)R1R2 and —COOH,
wherein R1 and R2 are independent from one another, and whereinR1 and R2 are selected from one of hydrogen, an aliphatic group with a main chain having 1 to about 20 carbon atoms, and an aromatic
group.
US Pat. No. 9,044,020

ISOLATED NUCLEOTIDE MOLECULE AND METHOD OF SENSING AND KILLING OF PATHOGENIC MICROORGANISM

Nanyang Technological Uni...

1. An isolated nucleic acid molecule comprising:
a first nucleotide sequence encoding a protein that is able to form a complex with an acyl homoserine lactone (AHL) produced
by a pathogenic microorganism; and

a second nucleotide sequence encoding an antimicrobial peptide, wherein the antimicrobial peptide is effective against the
pathogenic microorganism, wherein the second nucleotide sequence is under control of a promoter that is induced by the complex
of the protein encoded by the first nucleotide sequence and the acyl homoserine lactone (AHL) produced by said pathogenic
microorganism, and wherein the protein encoded by the second nucleotide sequence is a bacterocin.

US Pat. No. 9,295,456

OCCLUSION DEVICE FOR CLOSING ANATOMICAL DEFECTS

Nanyang Technological Uni...

1. An occlusion device for closing an anatomical defect in a tissue having an opening connecting a front side and a back side
of the tissue, the occlusion device comprising:
a scaffold that includes:
a proximal support structure comprising a first middle section, at least two arms extending from the first middle section,
and a first connector extending from the first middle section;

a distal support structure comprising a second middle section, at least two arms extending from the second middle section,
and a second connector extending from the second middle section;

a waist portion configured to extend through the opening of the anatomical defect and connecting the proximal support structure
with the distal support structure, the waist portion comprising a hollow tube with a proximal end and a distal end; and

a proximal occlusion film supported by the proximal support structure and a distal occlusion film supported by the distal
support structure, wherein:

the proximal support structure and the distal support structure are of a polymeric material,
the proximal support structure has a stiffness higher than a stiffness of the distal support structure,
the first connector comprises a first hollow joint protruding from the first middle section towards the waist portion,
the second connector comprises a second hollow joint protruding from the second middle section towards the waist portion,
the proximal support structure and the distal support structure are detachably connectable to the waist portion such that
the first hollow joint of the proximal support structure is configured to be inserted into the proximal end of the hollow
tube and the second hollow joint of the distal support structure is configured to be inserted into the distal end of the hollow
tube, and

the first hollow joint of the proximal support structure is integrally provided together with the at least two arms of the
proximal support structure and the hollow joint of the distal support structure is integrally provided together with the at
least two arms of the distal support structure.

US Pat. No. 9,226,912

ACETYLTANSHINONE IIA (ATA) AS ANTICANCER AGENT

Nanyang Technological Uni...

7. A method for treating cancer selected from breast cancer, cervical cancer, lung cancer, liver cancer, colorectal adenocarcinoma,
neuroblastoma, melanoma, and leukemia in a subject, comprising administering an effective amount of a compound of Formula
I to a subject in need thereof

US Pat. No. 9,475,701

QUINONE RADICALS FOR ENRICHING SPECIFIC SPECIES OF CARBON NANOTUBES

Nanyang Technological Uni...

1. A method for enriching specific species of carbon nanotubes, comprising:
contacting a composition of carbon nanotubes with one or more quinone compounds;
reacting the carbon nanotubes with the quinone compounds; and
separating the carbon nanotubes reacted with the quinone compounds from the unreacted carbon nanotubes,
wherein the one or more quinone compounds are of Formula (I):

wherein
R1, R2, R3, and R4 are each independently selected from the group consisting of H, halogen, —CN, —OR, —N3, —C(O)OR, —C(O)R, —C(O)NRR?, —NRC(O)R, —NRR?, —SOR, —SO2R, —NO2, a substituted or unsubstituted C1-6 alkyl group, a substituted or unsubstituted C2-6 alkenyl group, and a substituted or unsubstituted C2-6 alkynyl group, or

R1 and R2, and/or R3 and R4 combine to form a substituted or unsubstituted ring,

wherein
R and R? are each independently selected from the group consisting of H and C1-6 alkyl;

provided that the compound is not 2,3-dichloro-5,6-dicyano-1,4,-benzoquinone or tetrachlorobenzoquinone;
wherein the contacting step comprises suspending the composition of carbon nanotubes in an organic solvent containing the
one or more quinone compounds; and

wherein the reacting step comprises incubating the suspension under conditions that allow the quinone compounds to form radicals
that react with a specific species of the carbon nanotubes.

US Pat. No. 9,278,946

SMALL MOLECULE CATALYST FOR 5-HYDROXYMETHYLFURFURAL PRODUCTION FROM SACCHARIDES

NANYANG TECHNOLOGICAL UNI...

1. A method for preparing 5-(hydroxymethyl)furfural (HMF) comprising reacting a saccharide in the presence of an aryl- or
heteroaryl-boronic acid, wherein the boronic acid is of the following formula (I):

wherein, in formula (I), each of X, Y and Z are independently C, N, O, or S, or when at least one of Y, X, or Z is N, O or
S, the ring comprising Y, X and Z may be a 5 or 6 membered ring;

R1 is H, F, Cl, Br, I, NO2, CN, alkyl, OH, —NH2, —NHR2, —N(R)2, —SO2CH3, SO3H, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, —CF3, —CCl3, CHO, or COR6;

R2 is H, F, Cl, Br, I, NO2, CN, alkyl, OH, —NH2, —NHR2, —N(R)2, —SO2CH3, SO3H, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, —CF3, —CCl3, CHO, or COR6;

R3 is H, F, Cl, Br, I, NO2, CN, alkyl, OH, —NH2, —NHR2, —N(R)2, —SO2CH3, SO3H, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, —CF3, —CCl3, CHO, or COR6;

R4 is H, F, Cl, Br, I, NO2, CN, alkyl, OH, —NH2, —NHR2, —N(R)2, —SO2CH3, SO3H, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, —CF3, —CCl3, CHO, or COR6;

R5 is H, F, Cl, Br, I, NO2, CN, alkyl, OH, —NH2, —NHR2, —N(R)2, —SO2CH3, SO3H, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, —CF3, —CCl3, CHO, or COR6;

or wherein
independently each of R1 and R2, R2 and R3, R3 and R4, R4 and R5 taken together form an optionally substituted ring of 5 or 6 atoms, wherein the atoms are independently selected from C, N,
S and O; and wherein

R is selected from H, and C1-C6 alkyl; and

R6 is selected from H, C1-C6 alkyl, OH, Ph, Cl, and Br; wherein

the reaction is performed in the presence of a solvent, wherein the solvent is an ionic liquid; wherein
the reaction is carried out in an inert nitrogen atmosphere; and wherein
the reaction is performed at a temperature of 70 to 140° C.

US Pat. No. 9,583,693

PIEZOELECTRIC ENERGY HARVESTER

NANYANG TECHNOLOGICAL UNI...

1. A piezoelectric energy harvester comprising:
a metal substrate comprising
a planar part,
a first leg projecting from the planar part and
a second leg projecting from the planar part, the metal substrate configured to support a piezoelectric matrix on the planar
part between the first leg and the second leg; and

a piezoelectric matrix provided on the substrate, the piezoelectric matrix comprising a plurality of adjacent PZT elements.

US Pat. No. 9,625,397

ATOMIC-SCALED ELECTRONIC SPECTRUM INFORMATION PURIFICATION

NANYANG TECHNOLOGICAL UNI...

1. A method for electronic residual spectroscopy information purification for obtaining atomic-scaled, meaningful information
of a surface and sub-surface of a sample, the method comprising: collecting at least one reference spectrum, wherein the at
least one reference spectrum is from a clean and as close to perfect surface as possible; collecting a plurality of spectra
from the surface of the sample under varied conditions; subtracting a background from all the plurality of spectra; normalizing
the plurality of spectra; and subtracting the reference spectrum from the normalized plurality of spectra to give the meaningful
information.

US Pat. No. 9,608,760

INTEGRATED ACCESS NETWORK

Nanyang Technological Uni...

1. An optical terminal device comprising:
a signal modulator configured to generate a first signal modulated onto a first optical sideband of a first optical wavelength
signal and a second signal modulated onto a second sideband of the first optical wavelength signal;

a receiver configured to receive a third signal modulated onto a first optical sideband of a second optical wavelength signal
and a fourth signal modulated onto a second sideband of the second optical wavelength signal; and

a circulator coupled to the signal modulator and the receiver, wherein the circulator is configured to communicate with a
node of an integrated network via an optical fiber, wherein the first signal and the third signal are each a wired signal
and the second signal and the fourth signal are each a wireless signal.

US Pat. No. 9,599,584

IMBEDDED CHIP FOR BATTERY APPLICATIONS

CALIFORNIA INSTITUTE OF T...

1. A device for monitoring a condition of an electrochemical cell, the device comprising an integrated circuit comprising:
a voltage monitoring circuit for measuring a plurality of open circuit voltages of said electrochemical cell, said plurality
of open circuit voltages generated upon charging or discharging said electrochemical cell or stopping charging or discharging
said electrochemical cell;

a temperature monitoring circuit for measuring a plurality of temperatures of said electrochemical cell, said plurality of
temperatures generated upon charging or discharging said electrochemical cell or stopping charging or discharging said electrochemical
cell;

a current monitoring circuit for measuring a charging current of said electrochemical cell or a discharging current of said
electrochemical cell; and

a circuit for determining a thermodynamic parameter of said electrochemical cell, wherein said thermodynamic parameter is
one or more of a change in entropy of said electrochemical cell, a change in enthalpy of said electrochemical cell and a change
in free energy of said electrochemical cell, said circuit for determining a thermodynamic parameter positioned in electrical
or data communication with said temperature monitoring circuit to receive temperature measurements from said temperature monitoring
circuit, positioned in electrical or data communication with said voltage monitoring circuit to receive open circuit voltage
measurements from said voltage monitoring circuit and positioned in electrical or data communication with said current monitoring
circuit to receive current measurements from said current monitoring circuit or to provide thermodynamics parameters to said
current monitoring circuit;

wherein said device does not comprise a temperature controller or a means for controlling or establishing said plurality of
temperatures generated upon charging or discharging said electrochemical cell or stopping charging or discharging said electrochemical
cell.

US Pat. No. 9,576,698

METHODS FOR FORMING POLYIMIDE-CARBON NANOTUBE COMPOSITE FILM, AND POLYIMIDE-CARBON NANOTUBE COMPOSITE FILMS FORMED THEREOF

Nanyang Technological Uni...

1. A method for forming a polyimide-carbon nanotube composite film on a substrate, the method comprising
a) suspending carbon nanotubes in a solution comprising a poly(amic acid) and a solvent, the poly(amic acid) having the following
chemical formula


wherein
n is an integer; and the poly(amic acid) has a weight-average molecular weight (Mw) of 1.97×105 g/mol with a polydispersity index of 1.96;

b) casting the solution onto a substrate to form a layer on the substrate; and
c) heating the layer to convert the poly(amic acid) into a polyimide to form the polyimide-carbon nanotube composite film.

US Pat. No. 9,627,562

METHOD OF MANUFACTURING A MONOLAYER GRAPHENE PHOTODETECTOR AND MONOLAYER GRAPHENE PHOTODETECTOR

Nanyang Technological Uni...

1. A method of manufacturing a monolayer graphene photodetector comprising:
forming a graphene quantum dot array in a graphene monolayer; and
forming an electron trapping center in the graphene quantum dot array, wherein:
said photodetector has a photoresponse wavelength range from visible to mid-infrared;
the electron trapping center is in a mid-gap band; and
the photodetector has a photoresponse wavelength range in the entire range from visible to mid-infrared.

US Pat. No. 9,530,930

METHOD OF FABRICATING SEMICONDUCTOR DEVICES

NANYANG TECHNOLOGICAL UNI...

1. A method of fabricating semiconductor devices, the method comprising:
providing a continuous device layer on a substrate, the continuous device layer comprising a semiconductor material;
applying a patterning structure to the continuous device layer so that a first portion of the continuous device layer is masked
and a second portion of the continuous device layer is unmasked;

depositing a conductive material on the unmasked second portion of the continuous device layer to form a plurality of conductive
substrates on the continuous device layer, each conductive substrate being in electrical contact with a respective portion
of the continuous device layer;

applying a temporary supporting carrier to the conductive substrates with a low-melting point adhesive or a solvent-soluble
adhesive;

affixing a mounting tape to the device layer;
removing the temporary supporting carrier and adhesive so that the temporary supporting carrier and adhesive are not present
in the fabricated semiconductor device;

removing the patterning structure after depositing the conductive material; and
stretching the mounting tape after removing the temporary substrate and after removing the patterning structure so that the
continuous device layer is separated into a plurality of semiconductor devices, wherein the separation is substantially within
the first portion of the continuous device layer.

US Pat. No. 9,555,557

METHOD OF PREPARING HOLLOW METAL OR METAL OXIDE NANO- OR MICROSPHERES

Nanyang Technological Uni...

1. A method of preparing hollow metal or metal oxide nano- or microspheres, the method comprising:
a) providing a suspension comprising monodispersed polydopamine nano- or microspheres, wherein providing the suspension comprises:
1) providing a solvent system comprising water and at least one alcohol having the formula R—OH, wherein R is selected from
the group consisting of optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C3-C6 cycloalkenyl, and optionally substituted C6-C7 aryl,

2) adding dopamine to said solvent system to form a reaction mixture, and
3) agitating said reaction mixture for a time period of 1 to 10 days to form said monodispersed polydopamine nano- or microspheres;
b) forming a layer of metal or metal oxide on the monodispersed polydopamine nano- or microspheres; and
c) adding an alkaline solution to the suspension to dissolve the polydopamine thereby forming the hollow metal or metal oxide
nano- or microspheres.

US Pat. No. 9,663,800

ALKANE EXPORTER AND ITS USE

Nanyang Technological Uni...

1. A recombinant Saccharomyces cerevisiae cell expressing a heterologous ATP binding cassette 2 (ABC2) polypeptide having the amino acid sequence set forth in SEQ ID
NO:4, wherein the ABC2 polypeptide is capable of exporting C10-C11 alkanes.

US Pat. No. 9,653,962

APPARATUS AND AN ASSEMBLY FOR EMULATING AN IMPULSE FORCE EXERTED BY A SKELETAL MUSCLE

NANYANG TECHNOLOGICAL UNI...

1. An apparatus for emulating a force impulse exerted by a skeletal muscle, the apparatus comprising:
a mass;
an actuator, the actuator being adapted to exert a unidirectional force, a unidirectional torque, a unidirectional moment
or unidirectional couple on the mass; and

a clamping mechanism configured to apply a clamping force variable over a range from zero force up to a predetermined maximum
force and configured in use to selectively couple together the mass and the actuator,
wherein the unidirectional force, the unidirectional torque, the unidirectional moment or the unidirectional couple exerted
on the mass by the actuator emulates the force impulse.
US Pat. No. 9,755,227

METHOD FOR FORMING A REDUCED GRAPHENE OXIDE/METAL SULFIDE COMPOSITE AND ITS USE AS AN ANODE FOR BATTERIES

Nanyang Technological Uni...

1. A method for forming a reduced grapheme oxide/metal sulfide composite, comprising:
adding a dispersion comprising graphene oxide to hydrogen peroxide solution;
adding one or more metal complex or salt solution to the dispersion;
precipitating one or more peroxide-rich sol onto the graphene oxide surface to form one or more peroxide rich-metal oxide
precursor-supported grapheme oxide;

treating the supported graphene oxide with a sulfur source;
heating the treated supported graphene oxide at a first temperature to form a powder; and
heating the powder at a second temperature to form the reduced graphene oxide/metal sulfide composite,
wherein adding one or more metal complex or salt solution to the dispersion futher comprises adding one or more doping metal
precursor to the dispersion and wherein the metal of the one or more doping metal precursor is lithium or sodium.

US Pat. No. 9,616,031

METHOD FOR ENCAPSULATING PARTICLES

Nanyang Technological Uni...

1. A method for encapsulating particles of a water-insoluble material within a capsule of a water-insoluble polymer, comprising:
(a) dispersing particles of the water-insoluble material or a solution containing the water-insoluble material in a first
aqueous phase containing a first surfactant to obtain a first dispersion, wherein the water-insoluble material comprises or
consists of at least one polymer;

(b) collecting the particles of the water-insoluble material coated with the first surfactant;
(c) washing the collected particles;
(d) adding an aqueous suspension containing the washed surfactant-coated water-insoluble material particles to a polymer solution
containing the water-insoluble polymer of the capsule to obtain a polymer mixture; and

(e) dispersing the polymer mixture in a second aqueous phase containing a second surfactant to obtain a second dispersion
comprising the particles of the water-insoluble material encapsulated within the capsule of the water-insoluble polymer, wherein
the polymer of the water-insoluble material and the water-insoluble polymer are different, and wherein the water-insoluble
polymer has a faster degradation rate than the polymer of the water-insoluble material.

US Pat. No. 9,795,342

SYSTEM AND METHOD FOR PREDICTING ACUTE CARDIOPULMONARY EVENTS AND SURVIVABILITY OF A PATIENT

SINGAPORE HEALTH SERVICES...

1. A patient survivability prediction system comprising:
a patient worn device comprising
a first input to receive a first set of parameters relating to heart rate variability data of a patient, and
a second input to receive a second set of parameters relating to vital sign data of the patient;
a memory module to store the first set of parameters and the second set of parameters;
at least one processor coupled to the memory module and configured to analyze the first set of parameters and the second set
of parameters and output a prediction on the survivability of the patient over the next 72 hours based on the first set of
parameters and the second set of parameters; and

a display coupled to the at least one processor to display the prediction on the survivability of the patient over the next
72 hours.

US Pat. No. 9,551,759

DEVICES FOR TESTING A BATTERY AND METHODS FOR TESTING A BATTERY

Nanyang Technological Uni...

1. A device for testing a battery, the device comprising:
a determination circuit configured to determine for a plurality of charging states of the battery at least one of a derivative
entropy of the battery and a differential entropy of the battery; and

an evaluation circuit configured to evaluate a health state of the battery based on the determined at least one of the derivative
entropy and the differential entropy of the battery for the plurality of charging states of the battery, wherein:

the derivative entropy of the battery is based on an entropy state function of the battery and at least one of a lithium stoichiometry
in an anode of the battery and a lithium stoichiometry in a cathode of the battery; and

the differential entropy of the battery is based on the entropy state function of the battery before exposure to at least
one of a substantial voltage and a substantial temperature and on the entropy state function of the battery after exposure
to the at least one of the substantial voltage and the substantial temperature.

US Pat. No. 9,782,346

BIODEGRADABLE OCULAR IMPLANT

Nanyang Technological Uni...

1. A biodegradable ocular implant for sustained drug delivery, comprising a first layer comprising a first biodegradable polymer,
wherein the first layer contains a drug dispersed or dissolved therein.

US Pat. No. 9,683,991

METHOD OF GENERATING A METAMATERIAL, AND A METAMATERIAL GENERATED THEREOF

Nanyang Technological Uni...

3. A sensor for chemical or biological sensing comprising a metamaterial operable in the visible-infrared range comprising
split-ring resonators having a least line width of about 20 nm to about 40 nm on a non-conductive flexible substrate; and
a layer of conductive material directly between the split-ring resonators and the non-conductive flexible substrate.

US Pat. No. 9,637,394

METHOD OF PREPARING A TIO2 NANOSTRUCTURE

NANYANG TECHNOLOGICAL UNI...

1. A method of preparing a TiO2 nanostructure comprising:
(a) mixing an organic acid and an aminoalcohol to form an ionic liquid;
(b) heating the ionic liquid together with titanium ions and lithium ions to form a layered structure; and
(c) annealing the layered structure to form the TiO2 nanostructure.

US Pat. No. 9,807,847

FLEXIBLE AND/OR STRETCHABLE ELECTRONIC DEVICE AND METHOD OF MANUFACTURING THEREOF

NANYANG TECHNOLOGICAL UNI...

1. A flexible electronic device comprising
a) a flexible dielectric substrate having a first surface and an opposing second surface;
b) a first electrode layer arranged on the first surface of the flexible dielectric substrate;
c) a second electrode layer arranged on the second surface of the flexible dielectric substrate;
d) a functional layer comprising (i) a light emitting layer or (ii) an electroactive layer and an electrolyte layer, arranged
on the second electrode layer;

e) a third electrode layer arranged on the functional layer; and
f) a capping layer arranged on the third electrode layer.

US Pat. No. 9,801,831

DEVICE FOR CONTROLLED RELEASE OF A BIOACTIVE AGENT

Nanyang Technological Uni...

1. A device for controlled release of a bioactive agent, the device comprising a thin film located on the surface of the device,
wherein said thin film comprises a bioactive agent-containing layer comprising a polymeric matrix and at least one bioactive
agent, wherein the thin film further comprises a release layer between the bioactive agent-containing layer and the device
surface, and wherein the thin film further comprises an adhesive layer on top of the bioactive agent-containing layer, wherein
the bioactive agent-containing layer lies between the adhesive layer and the device surface, wherein the adhesion force between
the adhesive layer and target tissue is larger than the adhesion force between the release layer and the device surface to
allow delaminating of the thin film from the device surface and adhering of the thin film to the target tissue.

US Pat. No. 9,655,195

LIGHTING CONTROL METHOD AND SYSTEM

NANYANG TECHNOLOGICAL UNI...

1. A method for controlling a lighting device to generate light of a desired natural scene, the lighting device comprising
a plurality of warm white LEDs having a first intensity range and a plurality of cool white LEDs having a second intensity
range, the method comprising:
dividing each of the first intensity range and the second intensity range into a predetermined number of intensity levels;
initializing the plurality of warm white LEDs to a first intensity level and initializing the plurality of cool white LEDs
to a second intensity level, the first intensity level and the second intensity level being determined based on the desired
natural scene;

iteratively adjusting at least one of the intensity level of the warm white LEDs or the intensity level of the cool white
LEDs by at least one level in each iteration, until the light generated by the lighting device matches a desired correlated
color temperature predetermined for the desired natural scene; and

iteratively adjusting at least one of the intensity level of the warm white LEDs or the intensity level of the cool white
LEDs, until the light generated by the lighting device matches a desired illuminance predetermined for the desired natural
scene.

US Pat. No. 9,671,347

METHOD OF DIAGNOSING MALARIA INFECTION IN A PATIENT BY SURFACE ENHANCED RESONANCE RAMAN SPECTROSCOPY

Nanyang Technological Uni...

1. A method of diagnosing malaria infection in a patient by Surface Enhanced Raman Spectroscopy (SERS), comprising:
obtaining a sample from said patient;
mixing the sample with a suspension of magnetic nanoparticles, wherein said magnetic nanoparticles adsorb hemozoin present
in the sample onto their surface;

obtaining the SERS spectra of the sample;
subjecting the sample and suspension of magnetic nanoparticles to a magnetic field prior to and/or during obtaining the SERS
spectra of sample, wherein said subjecting comprises applying a magnetic force in a direction of the force of gravity by manipulating
a direction of the magnetic field; and

correlating the obtained SERS spectra to the presence or amount of hemozoin in the sample, wherein the presence of hemozoin
is indicative of malaria infection, wherein the magnetic nanoparticles comprise a core-shell structure, the shell of the core-shell
structure comprises a SERS active metal, and the hemozoin adsorbs onto surfaces of the core-shell structures of the magnetic
nanoparticles.

US Pat. No. 9,746,356

SENSOR, METHOD FOR FORMING THE SAME, AND METHOD OF CONTROLLING THE SAME

NANYANG TECHNOLOGICAL UNI...

1. A sensor for determining a flow parameter of a fluid, the sensor comprising:
a polymer membrane;
an elongate microstructure extending at least substantially perpendicularly from a surface of the polymer membrane; and
a strain gauge formed on the polymer membrane;
wherein the elongate microstructure is arranged to cause a displacement of the polymer membrane in response to a fluid flowing
and interacting with the sensor, and

wherein the strain gauge is configured to provide a measurement indicative of a flow parameter of the fluid based on the displacement
of the polymer membrane.

US Pat. No. 9,732,194

GRAFT COPOLYMERS OF A POLY(VINYLIDENE FLUORIDE)-BASED POLYMER AND AT LEAST ONE TYPE OF ELECTRICALLY CONDUCTIVE POLYMER, AND METHODS FOR FORMING THE GRAFT COPOLYMERS

Nanyang Technological Uni...

1. A method for forming a graft copolymer of a poly(vinylidene fluoride)-based polymer and at least one type of electrically
conductive polymer, wherein the electrically conductive polymer is grafted on the poly(vinylidene fluoride)-based polymer,
the method comprising the following steps a) through c) in sequential order:
a) irradiating a poly(vinylidene fluoride)-based polymer with a stream of electrically charged particles;
b) forming a solution comprising the irradiated poly(vinylidene fluoride)-based polymer, an electrically conductive monomer
and an acid in a suitable solvent; and

c) adding an oxidant to the solution to form the graft copolymer.

US Pat. No. 9,660,310

ELECTRODE MATERIALS FOR METAL-AIR BATTERIES, FUEL CELLS AND SUPERCAPACITORS

Nanyang Technological Uni...

1. An electrode comprised of:
a first layer comprised of a mesoporous nanostructured hydrophobic material; and
a second layer comprised of a mesoporous nanostructured hydrophilic material arranged on the first layer;
wherein the layers are free of a binder;
wherein the mesoporous nanostructured hydrophilic material further comprises a linker bound on its surface; and
wherein the mesoporous nanostructured hydrophilic material further comprises a catalytic nanostructure which is bound to the
surface of the mesoporous nanostructured hydrophilic material via the linker, wherein the linker is comprised of an unsaturated
carboxylic acid having 12 carbon atoms or less.

US Pat. No. 9,622,825

ROBOTIC SYSTEM FOR FLEXIBLE ENDOSCOPY

NATIONAL UNIVERSITY OF SI...

1. A method for using a flexible endoscopy system, the flexible endoscopy system comprising a robotic manipulator having (a)
a flexible member couplable to an endoscope and comprising a tendon sheath system including a tendon in a sheath, the tendon
deformable within the sheath such that the tendon and the sheath can exert forces upon and react against each other, the flexible
member having a first end and a second end, (b) an arm coupled to the first end of the flexible member such that the arm is
movable by the flexible member, (c) an end effector coupled to and movable by the arm, (d) a first actuator coupled to the
second end of the flexible member and configured for driving the arm, and (e) a tension sensor and a displacement sensor at
the second end of the flexible member, the method comprising:
sensing the tension sensor and the displacement sensor to obtain a set of sensor parameters;
determining an effective elongation constant Me of the tendon sheath system based upon the set of sensor parameters sensed at the second end of the flexible member; and

predicting as a function of the set of sensor parameters sensed at the second end of the flexible member (a) tendon sheath
system elongation including tendon elongation and sheath elongation at the first end of the flexible member and (b) force
experienced by the end effector, wherein the step of predicting does not require use of any sensor at the first end of the
flexible member, the arm, and the end effector.

US Pat. No. 9,601,013

TRAFFIC SIGNAL CONTROL METHOD AND TRAFFIC SIGNAL CONTROLLER

Massachusetts Institute o...

1. A distributed traffic signal control method for a directed network comprising a plurality of junctions, each of the plurality
of junctions having a plurality of links connected thereto, the links comprising one or more upstream links and one or more
downstream links, the method comprising:
activating one of a plurality of phases of each of the plurality of junctions for a predetermined time period which maximizes
the directed network throughput based on current differential traffic backlogs between said one or more upstream links and
said one or more downstream links connected to each of the plurality of junctions, each phase providing a unique combination
of traffic signals at each of the plurality of junctions for guiding traffic from said one or more upstream links to said
one or more downstream links, wherein said activating one of a plurality of phases is based on said current differential traffic
backlogs and a flow rate of traffic through each of the plurality of junctions; and

determining, for each phase, a parameter based on a sum of the multiplication of the current differential traffic backlog
with the flow rate of traffic for each unique combination of one upstream link and one downstream link of the plurality of
links connected to each of the plurality of junctions.

US Pat. No. 9,734,954

CONDUCTING POLYMER/GRAPHENE-BASED MATERIAL COMPOSITES, AND METHODS FOR PREPARING THE COMPOSITES

Nanyang Technological Uni...

1. A composite comprising a conducting polymer and a graphene-based material, the composite comprising
a) a graphene-based material doped with nitrogen or having a nitrogen-containing species selected from the group consisting
of an amine group, an amide group, and a nitrile group directly grafted to a graphitic carbon atom that forms part of a ring
structure of the graphene-based material, and

b) a coating consisting of the conducting polymer formed directly on a surface of the graphene-based material, wherein the
composite comprises 1 to 10 wt % of the conducting polymer.

US Pat. No. 9,711,760

LIGHT-EMITTING DEVICE, METHOD OF FORMING AND OPERATING THE SAME

Nanyang Technological Uni...

1. A light-emitting device comprising:
an active structure comprising an emissive halide perovskite layer, the halide perovskite layer comprising a halide perovskite
material;

a first injection electrode electrically coupled to the active structure;
a second injection electrode electrically coupled to the active structure;
a control electrode; and
an insulator layer between the control electrode and the active structure;
wherein the first injection electrode is configured to inject electrons into the active structure and the second injection
electrode is configured to inject holes into the active structure upon application of a potential difference between the first
injection electrode and the second injection electrode; and

wherein the control electrode is configured to generate an electric field upon application of a voltage, thereby causing simultaneous
accumulation of the electrons and the holes in a region of the halide perovskite layer so that the electrons and the holes
recombine, thereby emitting light.

US Pat. No. 9,700,653

METHOD FOR PREPARING A PATTERNED SUBSTRATE AND USE THEREOF IN IMPLANTS FOR TISSUE ENGINEERING

Nanyang Technological Uni...

1. A method for preparing a patterned substrate, the method comprising:
a) melt-spinning at least one biocompatible polymer to form fibers;
b) collecting the fibers on a substrate such that the fibers are aligned on the substrate; and
c) applying a binding agent to the aligned fibers to bond the fibers into the aligned arrangement to obtain the patterned
substrate in form of an aligned fiber mat.

US Pat. No. 9,663,382

METHOD OF SYNTHESIZING ANATASE TIO2 NANOSHEETS

NANYANG TECHNOLOGICAL UNI...

1. A method of synthesizing anatase TiO2 nanosheets, the method comprising the steps of:
(a) mixing a titanium complex with an ethanolamine derivative;
(b) adding sufficient water to completely hydrolyze the titanium complex to form a mixture, the mixture comprising Ti(OH)4; and

(c) heating the mixture at only one temperature ranging from about 150° C. to about 200° C. to obtain anatase TiO2 nanosheets having O-terminated {100} facets.

US Pat. No. 9,974,886

METHODS OF MANUFACTURING HYDROGEL MICROPARTICLES HAVING LIVING CELLS, AND COMPOSITIONS FOR MANUFACTURING A SCAFFOLD FOR TISSUE ENGINEERING

Nanyang Technological Uni...

1. A method of manufacturing hydrogel constructs comprising one or more species of living eukaryotic cells encapsulated therein, the method comprising:a) dissolving a hydrogel-forming agent in an aqueous medium to form a solution;
b) suspending one or more species of living eukaryotic cells in the solution to form a cell suspension;
c) dispersing the cell suspension into an organic oil to form a microemulsion;
d) subjecting the microemulsion to conditions that allow the hydrogel-forming agent to form hydrogel microparticles comprising said one or more species of living eukaryotic cells encapsulated and uniformly dispersed therein, wherein the hydrogel-forming agent solidifies to form the hydrogel microparticles;
e) mixing the cell-laden hydrogel microparticles with a second hydrogel solution;
f) suspending one or more species of living eukaryotic cells in the mixture of the cell-laden hydrogel microparticles and the second hydrogel solution;
g) subjecting the mixture from step f) to conditions that allow the second hydrogel to form at least one hydrogel comprising the cell-laden hydrogel microparticles encapsulated therein; and
h) degrading the hydrogel-forming agent of the encapsulated cell-laden hydrogel microparticles from step g) by melting by means of heat treatment at a temperature in the range from 20° C. to 37° C.,
wherein the hydrogel-forming agent comprises a physically cross-linkable polymer selected from the group consisting of gelatin, alginate, pectin, furcellaran, carageenan, chitosan, derivatives thereof, copolymers thereof, and mixtures thereof.

US Pat. No. 9,837,562

CAPACITIVELY COUPLED ELECTRODELESS PLASMA APPARATUS AND A METHOD USING CAPACITIVELY COUPLED ELECTRODELESS PLASMA FOR PROCESSING A SILICON SUBSTRATE

Nanyang Technological Uni...

1. A capacitive coupled electrodeless plasma apparatus for processing a silicon substrate, wherein capacitive coupled refers
to a potential drop across at least one inductive antenna comprised in the apparatus and wherein electrodeless refers to an
absence of electrodes in a plasma generated in a chamber of the apparatus, the apparatus comprising:
the at least one inductive antenna driven by time-varying power sources for providing at least one electrostatic field, the
at least one inductive antenna being configured to enable control of ion motion parallel to a surface of the silicon; and

the chamber for locating the silicon substrate,
wherein the at least one electrostatic field induced by the potential drop across the at least one inductive antenna is for
breakdown of feedstock gases and sustenance of discharge in the chamber.

US Pat. No. 9,764,301

SILICA AEROGEL COMPOSITE

Nanyang Technological Uni...

1. A method of preparing a silica aerogel composite, the method comprising
providing an aqueous solution comprising a water soluble polymeric binder and a surfactant,
adding a silyl-modified silica aerogel to the aqueous solution to form a mixture, and
freeze-drying the mixture under reduced pressure at a temperature sufficient to sublime water in the mixture, thereby physically
binding the water soluble polymeric binder to the silyl-modified silica aerogel to obtain the silica aerogel composite.

US Pat. No. 9,636,025

SYSTEMS AND METHODS FOR PEDAL REVASCULARIZATION ASSESSMENT

Nanyang Technological Uni...

1. A system for assessment of peripheral blood flow characteristics in deep tissue, the system comprising:
a support structure configured to be positioned onto a patient's foot;
at least one diffuse optical flow (DOF) sensor carried by the support structure and configured to be positioned in optical
communication with the skin surface of the patient's foot, the DOF sensor comprising a return optical conduit, and at least
one input optical fiber comprising an end configured to be positioned proximate the skin surface of the patient's foot, the
input optical fiber in optical communication with a coherent laser light source;

a photodetector operably connected to the at least one DOF sensor;
a software or hardware processor configured to analyze data from the at least one DOF sensor to determine blood flow characteristics
at a location near the at least one DOF sensor when the support structure is positioned onto the patient's foot, the hardware
or software processor configured to determine blood perfusion characteristics in the patient's arterioles and capillaries
by determining the spatial speckle contrast ratio (Ks) or the temporal speckle contrast ratio (Kt) and determining 1/Ks2 or 1/Kt2 from intensity fluctuations, and correlating 1/Kt2 or 1/Kt2 values with blood flow; and

a display configured to provide audible, visual, or tactile feedback indicative of the blood flow characteristics determined
by the hardware or software processor,

wherein the at least one DOF sensor is configured to capture light scattered diffusively into tissue and transmitted at a
depth of penetration of between 5 mm and 50 mm.

US Pat. No. 9,628,738

MOTION DETECTION IMAGE SENSORS AND METHODS FOR CONTROLLING A MOTION DETECTION IMAGE SENSOR

Nanyang Technological Uni...

1. An image sensor comprising:
a plurality of pixel cells, each pixel cell configured to convert incident light to an electric signal indicating the intensity
of the incident light;

a pixel determination circuit configured to determine a pixel cell of the plurality of pixel cells based on light incident
to the plurality of pixel cells; and

an output circuit configured to output the electrical signal of the determined cell;
wherein each pixel cell comprises:
a photo detector configured to convert incident light to an electric signal indicating the intensity of the incident light;
a criterion determination circuit configured to determine whether the incident light fulfills a pre-determined criterion;
and

an indication circuit configured to transmit an indication indicating that the incident light fulfills the pre-determined
criterion if the incident light fulfills the pre-determined criterion;

wherein the criterion determination circuit comprises a light change detector; and
wherein the criterion determination circuit comprises a high-pass filter configured to filter an output of the light change
detector;

wherein the light change detector is an electrical circuit configured to generate an electrical signal based on the change
in the output current of the photo detector.

US Pat. No. 9,603,877

ISOLATED NUCLEOTIDE MOLECULE AND METHOD OF SENSING AND KILLING OF PATHOGENIC MICROORGANISM

NANYANG TECHNOLOGICAL UNI...

1. An isolated nucleic acid molecule comprising:
(a) a first nucleotide sequence encoding a protein that is able to form a complex with a quorum sensing molecule produced
by a pathogenic microorganism;

(b) one or more second nucleotide sequences, wherein the one or more second nucleotide sequences are under the control of
a first inducible promoter that is induced by the complex of the protein encoded by the first nucleotide sequence and the
quorum sensing molecule produced by the pathogenic microorganism and encoding

(i) an antimicrobial peptide, wherein the antimicrobial peptide is effective against the pathogenic microorganism; and/or
(ii) an antibiofilm enzyme, wherein the antibiofilm enzyme is effective against the pathogenic microorganism; and
(c) a third nucleotide sequence under the control of a second inducible promoter, wherein the third nucleotide sequence encodes
a protein that controls the motility of the host organism and directs the motility of the host organism towards the pathogenic
microorganism;

wherein the quorum sensing molecule is an acyl homoserine lactone (AHL), wherein the protein encoded by the first nucleotide
sequence is a transcription factor, wherein the antimicrobial protein encoded by the second nucleotide sequence is a bacteriocin,
and wherein the antibiofilm enzyme encoded by the second nucleotide sequence is a nuclease.

US Pat. No. 9,983,127

OPTICAL DETECTION DEVICE AND OPTICAL DETECTION METHOD

Nanyang Technological Uni...

1. An optical detection device comprising:an optics arrangement configured to generate an annular illumination pattern to illuminate a portion of a sample and further configured to receive a return light from the portion of the sample illuminated by the annular illumination pattern;
a detector arrangement configured to detect the return light; and
a fiber assembly arranged to receive the return light and to optically couple the return light to the detector arrangement,
wherein the fiber assembly comprises a plurality of dead fibers and a plurality of live fibers, wherein the plurality of dead fibers and the plurality of live fibers are arranged in a plurality of concentric patterns at one end of the fiber assembly to receive the return light;
wherein the plurality of live fibers are arranged in a plurality of linear blocks at an opposite end of the fiber assembly;
wherein the optics arrangement further comprises a light director arranged to optically couple the return light towards the detector arrangement;
wherein the fiber assembly is arranged between the detector arrangement and the light director;
wherein a number of linear blocks corresponds to a number of concentric patterns; and
wherein the live fibers of each concentric pattern are arranged in a respective linear block of the plurality of linear blocks so that each linear block of the plurality of linear blocks corresponds to one concentric pattern.

US Pat. No. 9,861,465

METHOD FOR FORMING A TISSUE CONSTRUCT AND USE THEREOF

Nanyang Technological Uni...

1. An in vitro method for forming a tissue construct having a composite structure, comprising:
(a) providing a biodegradable substrate in vitro, wherein the substrate is adapted to allow deposition or growth of a plurality
of cells;

(b) providing a vascularized layer in vitro, the vascularized layer comprising a plurality of blood vessels therein; and
(c) adhering the vascularized layer to the biodegradable substrate in vitro.

US Pat. No. 9,748,838

METHOD OF OPERATING A CONTROLLER FOR A POWER CONVERTER, AND A CORRESPONDING CONTROLLER

NANYANG TECHNOLOGICAL UNI...

1. A controller for a power converter having a plurality of switches couplable to respective electrical devices, the controller
comprising:
a switch activating unit for activating the switches;
a frequency varying unit;
a comparator configured to compare respective electrical parameters of the electrical devices with respective reference electrical
parameters to obtain associated results; and

a selector configured to select based on the results, either no switches or at least one switch to be activated to enable
at least two electrical devices to be electrically connected,

wherein the activation is performed on receipt of a signal pulse, and if no switches are selected, the signal pulse is skipped
by the switch activating unit to reduce power consumption of the controller,

wherein based on the results, a frequency of the signal pulse is varied by the frequency varying unit to further reduce power
consumption of the controller,

and wherein the comparator and selector are configured to be switched off prior to receipt of the signal pulse.

US Pat. No. 9,738,986

METHOD OF MANUFACTURING LAYERED METAL OXIDE PARTICLES AND LAYERED METAL OXIDE PARTICLES FORMED THEREOF

Nanyang Technological Uni...

1. A method of manufacturing layered metal oxide particles, the method comprising:
placing a metal electrode in an electrolyte;
applying an electrical voltage to the metal electrode, wherein the metal electrode forms an anode, and the applying forms
a metal oxide layer on a surface of the metal electrode, and wherein the applied electrical voltage is higher than a breakdown
voltage of the metal oxide and breaks down the metal oxide layer formed on the metal electrode surface into metal oxide particles;
and

reacting the metal oxide particles with the electrolyte to form the layered metal oxide particles.

US Pat. No. 9,742,424

ANALOG-TO-DIGITAL CONVERTER

Nanyang Technological Uni...

1. An analog-to-digital converter (ADC) comprising:
a comparator arrangement comprising two comparators;
a digital-to-analog converter (DAC) arrangement comprising two DACs, wherein each DAC of the two DACs is connected to a respective
comparator of the two comparators; and

an adder circuit connected to the comparator arrangement,
wherein the ADC is configured to receive an input value and further configured, over a plurality of conversion cycles of the
ADC, to generate an output value representative of the input value,

wherein, for each respective DAC, the DAC is configured to sample the input value, and to generate a plurality of threshold
levels over the plurality of conversion cycles, the sampled input value and the plurality of threshold levels to be received
by the respective comparator, wherein the plurality of threshold levels are defined, at least in part, by predetermined redundancy
levels that are binary-scaled over the plurality of conversion cycles and generated by the DAC, and, wherein a respective
threshold level of the plurality of threshold levels is associated with a respective conversion cycle of the plurality of
conversion cycles,

wherein the comparator arrangement is configured to provide an output code for the respective conversion cycle based on the
sampled input value and the respective threshold level associated with at least one of the two comparators, and, wherein,
for at least two adjacent conversion cycles of the plurality of conversion cycles, the two comparators are adapted to collectively
provide output codes having two bits based on the sampled input value and the respective threshold levels associated with
the two comparators, wherein the respective threshold levels for a predetermined conversion cycle of the at least two adjacent
conversion cycles is dependent on the output code having two bits of a previous conversion cycle of the at least two adjacent
conversion cycles, and

wherein the adder circuit is configured to provide a plurality of output bits corresponding to the output value, wherein the
adder circuit is capable of overlapping and adding a first significant bit of the output code having two bits provided for
the predetermined conversion cycle with a second significant bit of the output code having two bits provided for the previous
conversion cycle to generate one output bit of the plurality of output bits.

US Pat. No. 9,732,175

CERAMIC-POLYMER NANOCOMPOSITES

Nanyang Technological Uni...

1. A method for preparing a ceramic-polymer nanocomposite, the method comprising
a) providing a polymer comprising radicals on a surface thereof;
b) contacting the polymer with a functionalizing agent comprising an alkaline solution selected from the group consisting
of alkali metal hydroxides, ammonium hydroxide, and mixtures thereof to form a functionalized polymer; and

c) either
(i) grafting a cross-linking agent onto the functionalized polymer to form a graft copolymer, and attaching ceramic nanostructures
to the graft copolymer to form a ceramic-polymer nanocomposite, or

(ii) grafting a cross-linking agent onto ceramic nanostructures to form modified ceramic nanostructures, and attaching the
modified ceramic nanostructures to the functionalized polymer to form a ceramic-polymer nanocomposite.

US Pat. No. 9,750,847

CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES

Nanyang Technological Uni...

1. A method of producing a chitosan hydrogel, comprising a step of polymerizing a polymerizable composition comprising a quaternized
chitosan derivative having polymerizable organic moieties, initiator, and water,
wherein said polymerizing comprises a step of irradiating ultraviolet (UV) to a photopolymerizable composition comprising
a quaternized chitosan derivative having polymerizable organic moieties, photoinitiator, and water,

wherein said quaternized chitosan derivative has the following formula,

wherein R? and R? are independently selected from the group consisting of optionally substituted C1-C18 alkyl, m is 2 or 3, n is 1 to 20.

US Pat. No. 9,754,727

ENERGY CHARGE STORAGE DEVICE USING A PRINTABLE POLYELECTROLYTE AS ELECTROLYTE MATERIAL

Nanyang Technological Uni...

1. An energy charge storage device comprising a first and second electrode and a printable polymer gel electrolyte positioned
between the first and second electrodes, wherein:
the polymer gel electrolyte forms a separator between the first and second electrodes and is in direct contact with the first
and second electrodes,

said polymer gel electrolyte consists of a printable homopolymeric polyelectrolyte or a printable copolymeric polyelectrolyte,
said homopolymeric polyelectrolyte comprises a single homopolymer or said copolymeric polyelectrolyte comprises a single copolymer,
and

said energy charge storage device is selected from the group consisting of a supercapacitor, a hybrid electrochemical capacitor,
and a metal-hydride battery.

US Pat. No. 9,709,583

MALDI/SELDI ANALYSIS OF COMPLEX MIXTURES COMPRISING HYDROPHILIC AND HYDROPHOBIC ANALYTES

Frederick Rowell, Durham...

1. A method of preparing and analyzing a complex liquid sample comprising a hydrophilic target constituent and a hydrophobic
target constituent, comprising:
mixing the sample with hydrophilic and hydrophobic silica particles on a plate suitable for MALDI/SALDI analysis to form a
first complex between the hydrophilic target constituent and the hydrophilic silica particles and a second complex between
the hydrophobic target constituent and the hydrophobic silica particles, wherein either the hydrophilic or the hydrophobic
silica particles are functionalized to include a magnetic component;

separating the first complex from the second complex by selectively positioning at least one magnet with respect to at least
one of the first and the second complex and removing one complex from another directly on the plate using the at least one
magnet; and

carrying out a MALDI/SALDI analysis on the separated first complexes, without further addition of a citrate or a MALDI/SALDI
matrix,

wherein the sample is not washed or rinsed after the separation and before carrying out the MALDI/SALDI analysis.

US Pat. No. 9,969,739

TRICYCLIC CHIRAL COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYSIS

Nanyang Technological Uni...

1. A compound of Formula (VIII)the compound having a bowl-shaped conformation,wherein M is a metal selected from the group consisting of Boron, Aluminum, Zinc, Tin, Titanium, Zirconium, Indium, Copper, Iridium, and Lanthanum,
wherein R is —COOR3,
wherein R3 is hydrogen, or an aliphatic group with a main chain having 1 to about 20 carbon atoms, and
each of R1 and R2 are independent from one another and selected from one of hydrogen, an aliphatic group with a main chain having 1 to about 20 carbon atoms and phenyl group.

US Pat. No. 9,813,704

LOSSLESS IMAGE AND VIDEO COMPRESSION

NANYANG TECHNOLOGICAL UNI...

1. A method of encoding an intra predicted residual block of an image for use in image or video compression, wherein the intra
predicted residual block is associated with an intra prediction coding mode, the method comprising:
generating a plurality of residual error blocks from the intra predicted residual block, wherein the residual error blocks
include residual data with different statistical characteristics from the residual data in the intra predicted residual block;

scanning and entropy coding each of the residual error blocks to produce a first plurality of bit streams and recording the
lengths of each of the first plurality of bit streams;

scanning and entropy coding the intra predicted residual block to produce a second bit stream and recording the length of
the second bit stream;

selecting the minimum length bit stream from the first plurality of bit streams and the second bit stream as the output coded
bit stream of the intra predicted residual block.

US Pat. No. 9,813,760

MULTI-SCREEN MEDIA DELIVERY SYSTEMS AND METHODS

NANYANG TECHNOLOGICAL UNI...

1. An apparatus comprising a plurality of independent physical computer systems arranged to cooperate to implement a virtual
computer system,
the virtual computer system being arranged to communicate with multiple video display devices each of which has at least one
screen, the video display devices having predefined relationships with a plurality of users whereby each of the users is associated
with a respective sub-set of the display devices, and at least one of the respective sub-sets of display devices comprises
a plurality of display devices;

the virtual computer system being arranged to communicate with a plurality of databases storing media content, and to deliver
the media content selectively to the video display devices,

the virtual computer system being arranged to perform, for each said user, a respective process referred to as a cloudclone,
each cloudclone including:
respective threads for each of the corresponding sub-set of video display devices, which manage the transfer of media content
to the corresponding sub-set of video display devices;

one or more applications which obtain media content from at least one of the databases; and
an inter device message bus which transfers content from the one or more applications selectively to the threads.

US Pat. No. 9,930,766

APPARATUS AND METHOD FOR DETERMINING THE TYPE, DENSITY AND TEMPERATURE OF NEUTRAL RADICALS IN PLASMA

NANYANG TECHNOLOGICAL UNI...

1. An apparatus for diagnostics of neutral radicals in plasma, the apparatus comprising:a portable probe configured to be attached to and extend into a plasma chamber to obtain information from plasma contained in the plasma chamber, the probe comprising
a metallic rod configured to be biased with an alternating current voltage applied to the metallic rod to obtain current measurements;
a transparent dielectric sleeve having a bandgap configured to allow light transmission to obtain optical emission spectra from the plasma;
an insulated thermocouple provided in the metallic rod, the thermocouple configured to measure equilibrium temperature of the probe; and
a computer configured to analyse information obtained by the probe and to determine the type, density and temperature of neutral radicals in the plasma.

US Pat. No. 9,867,525

HIGH SENSITIVITY TEMPORAL FOCUSING WIDEFIELD MULTIPHOTON ENDOSCOPE CAPABLE OF DEEP IMAGING

NANYANG TECHNOLOGICAL UNI...

1. An imaging system comprising:
a pulsed light source that provides pulsed light;
one or more dispersive elements that are positioned to receive the pulsed light and apply selective dispersive properties
to recombine the spectrally dispersed pulse at a certain position along the optical axis where with the recombined pulse,
a sequence of two photon (2p) wide field uniform illumination and 2p wide field structured illumination is generated at the
focal plane; and

an imaging element that receives multiple 2p wide field uniform illumination and 2p wide field structured illumination images
to produce respective 3D resolved images of a sample, wherein the group velocity dispersion (GVD) of the pulsed light is tuned
to induce a quadratic spectral phase, which effectively shifts the focal plane and thereby allows scanning in the axial direction
of the pulsed light.

US Pat. No. 9,831,866

SWITCHING CIRCUIT

Nanyang Technological Uni...

1. A switching circuit comprising:
a transmission line arrangement comprising a plurality of transmission lines coupled to each other by at least one of an electric
coupling or a magnetic coupling; and

at least one switching element arrangement coupled to at least one transmission line of the plurality of transmission lines,
wherein, in a first mode of operation, the at least one switching element arrangement is configured in a first state,
wherein, in a second mode of operation, the at least one switching element arrangement is configured in a second state, and
wherein the transmission line arrangement is configured to, depending on whether the at least one switching element arrangement
is configured in the first state or whether the at least one switching element arrangement is configured in the second state,
generate a standing wave from an input signal received by the transmission line arrangement, the standing wave being coupled
between at least some of the plurality of transmission lines through the at least one transmission line into an output signal,

wherein the output signal is transmitted from the transmission line arrangement.

US Pat. No. 9,823,150

MICRO-MACHINED OPTICAL PRESSURE SENSORS

Agency for Science, Techn...

1. A micro-machined optical pressure sensor, comprising:
a diaphragm configured to deform when a force is applied thereto;
a sensing micro-ring spaced apart from the diaphragm by a gap, the gap being variable depending on the force applied on the
diaphragm; and

a reference micro-ring spaced apart from the sensing micro-ring, the reference micro-ring configured to produce a reference
resonance wavelength shift, the reference resonance wavelength shift indicative of the temperature of the micro-machined optical
pressure sensor;

wherein the sensing micro-ring is configured to produce a resonance wavelength shift when the gap is varied, the resonance
wavelength shift indicative of the force applied to the diaphragm,

wherein the reference micro-ring is configured to compensate a temperature-dependent resonance shift within the resonance
wavelength shift produced by the sensing micro-ring when the gap is varied.

US Pat. No. 9,815,868

PEPTIDES BINDING TO PARALLEL-STRANDED G-QUADRUPLEXES

Nanyang Technological Uni...

1. A conjugate comprising a peptide, wherein said peptide comprises or consists of (i) the amino acid sequence of SEQ ID NO:1
or (ii) an amino acid sequence having at least 80% sequence identity to the amino acid sequence of SEQ ID NO:1 over its entire
length and further comprises at least one functional moiety, wherein said at least one functional moiety is conjugated to
the N-terminus of said peptide with the proviso that said at least one functional moiety does not comprise the amino acid
sequence set forth in SEQ ID NO:2 or a C-terminal fragment thereof.

US Pat. No. 10,049,916

METHOD OF MANUFACTURING A GERMANIUM-ON-INSULATOR SUBSTRATE

Massachusetts Institute o...

1. A method of manufacturing a germanium-on-insulator substrate, comprising:(i) providing a first semiconductor substrate, and a second semiconductor substrate formed with a germanium layer;
(ii) bonding the first semiconductor substrate to the second semiconductor substrate using at least one dielectric material to form a combined substrate, the germanium layer being arranged intermediate the first and second semiconductor substrates;
(iii) removing the second semiconductor substrate from the combined substrate to expose at least a portion of the germanium layer with misfit dislocations; and
(iv) annealing the combined substrate to enable removal of the misfit dislocations from the portion of the germanium layer; and
(v) etching the combined substrate to remove a layer of material formed on the portion of the germanium layer as a result of the annealing to enable removal of the misfit dislocations from the portion of the germanium layer,
wherein the layer of material substantially includes the misfit dislocations.
US Pat. No. 9,863,941

MICROCHIP AND METHOD FOR DETECTING MOLECULES AND MOLECULAR INTERACTIONS

Nanyang Technological Uni...

1. A microchip comprising:
a substrate;
an inlet channel in said substrate;
an outlet channel in said substrate for guiding fluid below a fluid level in said outlet channel;
a plurality of test channels in said substrate formed between said inlet channel and said outlet channel, for guiding fluid
flow from said inlet channel to said outlet channel, each one of said test channels having an inlet connected with said inlet
channel and an outlet connected with said outlet channel, said inlet elevated from said outlet for inhibiting back flow through
said inlet, said outlet elevated from said fluid level for inhibiting back flow through said outlet; and

one test site in each one of said test channels, for detection of at least one specific molecule and a molecular interaction
at said test site;

wherein each one of said inlet channel, said outlet channel, and said test channels has a substantially flat bottom, said
bottom of said inlet channel elevated from said bottoms of said test channels, said bottoms of said test channels elevated
from said bottom of said outlet channel and elevated from said fluid level in said outlet channel;

wherein at least one of said test channels comprises a well for holding fluid therein; and
wherein at least one of said test channels comprises an overflow wall for forming said well, said overflow wall defining the
outlet of said at least one of said test channels.

US Pat. No. 9,847,045

APPARATUS FOR UPPER BODY MOVEMENT

Nanyang Technological Uni...

1. A rehabilitation human-machine interaction apparatus for upper body movement, the apparatus comprising:
a H-shaped cable-driven mechanism comprising only one cable;
two motors for driving the H-shaped cable-driven mechanism, a driving pulley coupled to each motor;
a plurality of guides arranged along the x and y axes; and
a manipulandum coupled to the H-shaped cable-driven mechanism for independent movement along x and y axes, wherein the manipulandum
includes:

a horizontal carriage;
a solid base mounted to the horizontal carriage;
a six degree of freedom force/torque sensor mounted to the solid base;
a plurality of idler pulleys; and
a plurality of vertical carriages;
characterized in that
four force channels are available, horizontal and vertical channels being passively obtained by providing mechanical stops
on the vertical and horizontal carriages respectively to mechanically block the vertical and horizontal carriages respectively,
and 45° channels being passively obtained by providing mechanical stops on one of the driving pulleys to block the driving
pulley.

US Pat. No. 9,826,955

AIR CONDUCTION SENSOR AND A SYSTEM AND A METHOD FOR MONITORING A HEALTH CONDITION

Nanyang Technological Uni...

1. A system for monitoring a health condition of a user, comprising:
an air conduction sensor for detecting a sound from the user, comprising:
a housing comprising an opening, wherein a rim of the opening is configured to be disposed on a skin or a clothing of the
user; and

a microphone coupled to the housing such that there is an air gap between the microphone and the skin or the clothing, wherein
the microphone is configured to detect the sound,

a filter and an amplifier in electrical communication with the microphone, the filter and the amplifier configured to process
the sound;

an analogue-to-digital converter configured to convert the sound detected into a digital signal;
a selection circuit configured to select a predetermined number of samples from the digital signal;
a transformation circuit configured to transform the selected predetermined number of samples into a plurality of frequency
components;

an entropy determination circuit configured to determine at least one entropy-based parameter value based on the plurality
of frequency components; and

an entropy comparator circuit configured to compare the at least one entropy-based parameter value determined with a predetermined
threshold value to detect a health signal for monitoring the health condition.

US Pat. No. 10,049,947

METHOD OF MANUFACTURING A SUBSTRATE

Massachusetts Institute o...

1. A method of manufacturing a substrate, comprising:(i) providing a first semiconductor substrate, which includes an at least partially processed CMOS device layer, a layer of first wafer material and a first layer of dielectric material arranged intermediate the partially processed CMOS device layer and layer of first wafer material;
(ii) bonding a handle substrate to the partially processed CMOS device layer and removing the layer of first wafer material,
wherein removing the layer of first wafer material includes:
removing at least a portion of the layer of first wafer material using mechanical grinding;
depositing a layer of protective material on the handle substrate; and
etching the first semiconductor substrate bonded with the handle substrate to substantially remove any remaining portions of the layer of first wafer material;
(iii) providing a second semiconductor substrate having a layer of second wafer material which is different than silicon;
(iv) bonding the first and second semiconductor substrates to form a combined substrate by bonding the layer of second wafer material to the partially processed CMOS device layer,
wherein bonding the layer of second wafer material to the partially processed CMOS device layer includes:
removing the first layer of dielectric material, subsequent to etching the first semiconductor substrate;
depositing a second layer of dielectric material on the partially processed CMOS device layer to replace the removed first layer of dielectric material; and
bonding the second layer of dielectric material to the layer of second wafer material of the second semiconductor substrate to form the combined substrate; and
(v) removing the handle substrate from the combined substrate to expose at least a portion of the partially processed CMOS device layer.

US Pat. No. 9,925,592

METHOD FOR FABRICATING A GOLD NANOPARTICLE

Nanyang Technological Uni...

1. Method for fabricating a gold nanoparticle, the method comprising the steps of:contacting a gold ion with a protein, wherein the protein has an inner cavity that can accommodate the gold ion;
separating the protein with the encapsulated gold ion(s) from non-encapsulated gold ions;
contacting the protein-encapsulated gold ion with a first reductant to reduce the gold ion and form a gold nanocluster seed in the inner cavity of the protein by adding the first reductant to a solution comprising the protein-encapsulated gold ion, wherein the first reductant is a strong reductant; and
contacting the gold nanocluster seed in the inner cavity of the protein with a second reductant to mineralize and grow the gold nanoparticle by separately adding the second reductant to the solution after the first reductant is added to the solution, wherein the second reductant is a weak reductant.

US Pat. No. 9,874,689

METHOD OF FORMING AN INTEGRATED CIRCUIT AND RELATED INTEGRATED CIRCUIT

National University of Si...

1. A method of forming an integrated circuit, comprising:
(i) forming at least a pair of optoelectronic devices from at least a first wafer material arranged on a semiconductor substrate,
the first wafer material different to silicon;

(ii) etching the first wafer material to form a first recess to be filled with a second material;
(iii) processing the second material to form a waveguide for coupling the pair of optoelectronic devices to define an optical
interconnect; and

(iv) bonding at least one partially processed CMOS device layer having at least one transistor to the semiconductor substrate
to form the integrated circuit, the partially processed CMOS device layer arranged adjacent to the optical interconnect.

US Pat. No. 9,819,145

LASER AND INTEGRATED GRAPHENE MODULATOR

Nanyang Technological Uni...

1. A layer arrangement comprising:
a graphene layer;
a gating electrode layer configured to provide a tuning voltage to the graphene layer;
a laser layer configured to provide an electromagnetic wave, the laser layer comprising an active region, the active region
being un-etched; and

a concentric-circular grating layer configured to couple the electromagnetic wave to the graphene layer, the concentric-circular
grating layer comprising a plurality of concentric rings,

wherein innermost rings of the plurality of concentric rings are electrically connected together, and outer rings of the plurality
of concentric rings are electrically unconnected to the innermost rings,

wherein the innermost rings are configured to electrically pump the active region.

US Pat. No. 9,876,066

DEVICE AND STRUCTURE AND METHOD FOR FORMING THE SAME

Nanyang Technological Uni...

1. A method for forming a device, the method comprising:
forming a first electrode on a substrate;
forming a second electrode on the substrate;
forming a contact layer at least partially on a substrate;
forming a device structure comprising a nanomaterial, the first electrode and the second electrode, the nanomaterial adhered
to the contact layer such that the nanomaterial forms a channel having a first end and a second end, wherein the first end
is electrically coupled to the first electrode and the second end is electrically coupled to the second electrode, wherein
a first portion of the contact layer is on the substrate and at least a portion of the channel is between a second portion
of the contact layer and the substrate;

depositing a transfer medium such that the device structure is covered by the transfer medium;
solidifying the transfer medium; and
peeling off the contact layer, the device structure and the transfer medium from the substrate;
wherein the contact layer has a greater adhesion to the device structure than to the substrate; and
removing the contact layer after peeling off the contact layer, the device structure and the transfer medium from the substrate.

US Pat. No. 10,062,538

ELECTRON DEVICE AND METHOD FOR MANUFACTURING AN ELECTRON DEVICE

Nanyang Technological Uni...

1. An electron device comprising:a support substrate;
a conductive planar slow-wave structure on the support substrate, the conductive planar slow-wave structure being adapted to receive an electromagnetic wave signal for interaction with an electron beam; and
a dielectric layer arrangement in between the conductive planar slow-wave structure and the support substrate, the dielectric layer arrangement being arranged on the support substrate only on one or more portions of the support substrate which are overlapped by the conductive planar slow-wave structure.

US Pat. No. 9,966,726

EMISSION SOURCE AND METHOD OF FORMING THE SAME

NANYANG TECHNOLOGICAL UNI...

1. An emission source comprising:a gain medium that provides optical amplification, the gain medium comprising a three-dimensional halide perovskite material; and
a pump source configured to provide energy to the gain medium comprising the three-dimensional halide perovskite material so that the gain medium generates a coherent stimulated light to emit a laser beam and the gain medium generates amplified spontaneous emission based on the energy provided,
wherein the three-dimensional halide perovskite material is a halide semiconductor material, and
wherein the gain medium has a trap density below 1018 cm?3.

US Pat. No. 9,923,208

ELECTROLYTE MEMBRANE FOR LIQUID ANODE CELL BATTERY

NANYANG TECHNOLOGICAL UNI...

1. A liquid anode cell battery, comprising:
a liquid anode comprising metal ions and an electron acceptor dissolved in a solvent; and
an electrolyte membrane in contact with the liquid anode, wherein the electrolyte membrane is partially or completely coated
with a coating protective against decomposition of the electrolyte membrane by the liquid anode.

US Pat. No. 9,915,670

METHOD OF DETECTING HYDROGEN PEROXIDE

Nanyang Technological Uni...

1. A method of detecting one or more analytes comprising hydrogen peroxide using surface enhanced Raman spectroscopy (SERS),
the method comprising
a) providing a SERS-active substrate having at least one metal carbonyl cluster compound attached thereon;
b) contacting the one or more analytes with the SERS-active substrate; and
c) detecting changes in surface enhanced Raman signal from the at least one metal carbonyl cluster compound as an indication
of the presence of the one or more analytes comprising hydrogen peroxide.

US Pat. No. 9,899,793

EMISSION SOURCE AND METHOD OF FORMING THE SAME

NANYANG TECHNOLOGICAL UNI...

1. An emission source comprising:
a gain medium comprising a halide semiconductor material; and
a pump source configured to provide energy to the gain medium comprising the halide semiconductor material so that the gain
medium generates a coherent stimulated light to emit a laser beam and the gain medium generates amplified spontaneous emission
based on the energy provided,

wherein the halide semiconductor material comprises a lead-free perovskite material,
and wherein the gain medium further comprises an additive to control trap density.
US Pat. No. 9,879,142

MICROENCAPSULATION OF ORGANIC SILANES AND THEIR USE AS SELF HEALING MATERIALS

NANYANG TECHNOLOGICAL UNI...

1. A poly(urea-formaldehyde) microcapsule, the poly (urea-formaldehyde) microcapsule comprising encapsulated within the microcapsule
an organofluorine silane of the general formula (I) A3C(CA2)pSiR1yX(3-y) (I), wherein in formula (I) A is either fluorine (F) or hydrogen (H), wherein at least about 50% of atoms A are fluorine,
X is chloro or a group RO, wherein R is a linear or branched alkyl radical of 1 to 4 carbon atoms, R1 is a linear, branched or cyclic alkyl group of 1 to 8 carbon atoms, y=0 or 1 or 2 and p=0 to 20.

US Pat. No. 9,868,109

TITANATE / TITANIA COMPOSITE NANOPARTICLE

Nanyang Technological Uni...

1. A composite nanoparticle having a composition comprising a phase of each of protonated titanate and titania (titanium dioxide),
wherein the phases of protonated titanate and titania in the composition are uniformly mixed and are mutually inter-dispersed
such that there are no morphologically distinct portions, and wherein the nanoparticle comprises 35 to 75 percent protonated
titanate and 65 to 25 percent titania and wherein the composition is dried.

US Pat. No. 9,866,188

DEAD TIME CIRCUIT FOR A SWITCHING CIRCUIT AND A SWITCHING AMPLIFIER

Nanyang Technological Uni...

1. A dead time circuit for a switching circuit, the dead-time circuit comprising:
(i) an input for receiving a switching signal of the switching circuit with at least one supply rail having a ground bounce
signal;

(ii) first and second outputs;
(iii) a first feedforward path coupled to the first output and arranged to receive the switching signal;
(iv) a second feedforward path coupled to the second output and arranged to receive the switching signal;
(v) a first feedback path forming a first feedback loop between the first output and the second feedforward path; and
(vi) a second feedback path forming a second feedback loop between the second output and the first feedforward path;
wherein each of the first and second feedforward paths includes a respective first and second delay circuit, each having a
time delay greater than a time period of the ground bounce signal determined according to the equation: t=2?(LC)?0.5,

where t is the time period of the ground bounce signal, L is the inductance of a bonding wire and C is the capacitance of
the at least one supply rail.

US Pat. No. 10,035,990

SPECIFIC INTERNALIZATION OF NANOPARTICLES INTO PROTEIN CAGES

Agency for Science, Techn...

1. A method for internalization of nanoparticles into protein cages comprising the following steps:(i) modifying a protein cage at predefined locations with one or more residues of histidines to provide accessible histidine residues displayed on an interior surface of the protein cage;
(ii) functionalizing nanoparticles to be able to bind the one or more residues of histidines; and
(iii) introducing the nanoparticles through holes in the protein cage; wherein the protein cage is made from dihydrolipoyl acetyltransferase.

US Pat. No. 9,987,399

NON-BIODEGRADABLE STENT COMPRISING A BIODEGRADABLE COATING AND METHOD OF COATING THE SAME

Nanyang Technological Uni...

1. A non-biodegradable stent comprising a biodegradable coating wherein said coating comprises one or more polymer layers comprising a biodegradable polymer and a plasticizer selected from the group consisting of triethyl citrate (TEC), a polyalkylene glycol, propylene glycol (PG) glycerol, di-2-ethylhexyladipate, di-2-ethylhexylphthalate, dicyclohexylphthalate, diisononyladipate, diisononylphthlate, n-butyl benzyl phthalate, and glycerol, wherein the plasticizer is contained in the one or more polymer layers in an amount from 1-30 wt %, based on dry weight of the one or more polymer layers, and wherein said coating comprises a drug combination of (i) triflusal and sirolimus or (ii) triflusal and a sirolimus derivative, the drug combination being present in an amount of about 0.1-35 wt %, based on dry weight of the drug containing layer.

US Pat. No. 9,988,380

QUORUM SENSING INHIBITORS

Nanyang Technological Uni...

1. A method for the treatment of a bacteria-related disease or disorder caused by Pseudomonas aeruginosa in a subject having the bacteria-related disease or disorder, wherein the method comprises:administering a therapeutically effective amount of a compound selected from the group consisting of:
and combinations thereof;wherein the subject is a mammal; and
wherein the disease or disorder is selected from endocarditis, respiratory and pulmonary infections, bacteremia, central nervous system infections, ear infections, eye infections, bone and joint infections, urinary tract infections, gastrointestinal infections, skin infections, soft tissue infections, pyoderma, dermatitis and combinations thereof.
US Pat. No. 9,976,116

PROGRAMMABLE SYNTHETIC LYSIS SYSTEM FOR CONTROLLED RELEASE OF MACROMOLECULES

Nanyang Technological Uni...

1. An expression system comprising one or more nucleic acid constructs, wherein the one or more nucleic acid constructs comprise:(i) a first gene encoding for one or more protein(s) that activate a quorum sensing system; wherein the quorum sensing system is one or more of an rhl quorum sensing system, an las quorum sensing system, and combinations thereof; and
(ii) a second gene encoding for one or more bacteriophage lytic protein(s) capable of forming a lesion in a host cell's membrane;
wherein the first gene is under control of a first promoter and the second gene is under control of a second promoter, wherein the first promoter controlling the first gene is a carbon starvation-induced promoter and the second promoter is a quorum sensing system promoter induced by the quorum sensing system activated by one or more protein(s) encoded by the first gene.

US Pat. No. 9,977,018

ELECTROCHEMICAL LATERAL FLOW BIOASSAY AND BIOSENSOR

NANYANG TECHNOLOGICAL UNI...

1. An electrochemical lateral flow biosensor (ELFB) strip comprising:(a) a polymeric hydrophobic membrane, wherein said membrane provides a solid support and enables a capillary flow of a liquid sample along the strip;
(b) a conjugation pad, wherein said conjugation pad is positioned over and in contact with said membrane at a first end of said membrane and said conjugation pad contains adsorbed dehydrated labelled conjugate particles,
wherein said conjugate particles are coated with a biorecognition element of an assay and are coated or filled with an electrochemically active component (EAC);
(c) a sampling pad, wherein said sampling pad is positioned on top of and in contact with said conjugation pad and provides adsorption of the liquid sample;
(d) a screen-printed electrode (SPE), wherein said SPE is placed in contact with said membrane at a second end of said membrane and said SPE is coated with immobilised capture antibodies, wherein said EAC of said conjugate particles is configured to transfer electrons to said SPE upon binding of said biorecognition element to said immobilised capture antibodies; and
(e) a wick pad, wherein said wick pad is positioned on top and in contact with said SPE and provides absorption of excess reagents and maintains a lateral flow of the liquid sample along the strip.

US Pat. No. 9,975,776

COMPOSITE FILM AND METHOD OF FORMING THE SAME

Nanyang Technological Uni...

1. A method of forming a metal oxide/reduced graphene oxide composite film, the method comprising:providing a graphene oxide dispersion;
adding a metal oxide to the graphene oxide dispersion to form a metal oxide/graphene oxide dispersion;
forming a metal oxide/graphene oxide film by filtering the metal oxide/graphene oxide dispersion using a directional flow directed assembly;
adhering the metal oxide/graphene oxide film on an absorbent material; and
reducing the metal oxide/graphene oxide film using a reducing agent to form the metal oxide/reduced graphene oxide composite film;
wherein excess reducing agent is absorbed by the absorbent material to reach a back surface of the metal oxide/graphene oxide film, the back surface of the metal oxide/graphene oxide film being surface adhered to the absorbent material, during reduction of the metal oxide/graphene oxide film.

US Pat. No. 9,976,042

CONDUCTIVE PASTE, METHOD FOR FORMING AN INTERCONNECTION AND ELECTRICAL DEVICE

Nanyang Technological Uni...

1. A conductive paste having a composition comprising a plurality of conductive nanoparticles and a plurality of conductive nanowires, wherein a weight ratio of the plurality of conductive nanoparticles to the plurality of conductive nanowires is between 10:1 and 50:1.

US Pat. No. 9,956,195

STABLE LIPOSOMAL FORMULATIONS FOR OCULAR DRUG DELIVERY

Nanyang Technological Uni...

1. A stable liposomal formulation for ocular delivery, the formulation comprising a liposome formed of palmitoyl oleoyl phosphatidyl choline (POPC), and latanoprost encapsulated in the liposome, wherein the liposome has a diameter of 100 nm to 300 nm, POPC is the sole lipid in the liposome, and the formulation is stable at 4° C. for up to 6 months.

US Pat. No. 9,955,238

METHODS AND SYSTEMS FOR WIRELESS TRANSMISSION OF DATA BETWEEN NETWORK NODES

Nanyang Technological Uni...

1. A method for communicating data within a network,the network comprising at least one sink node and a plurality of sensor nodes distributed in an environment, each sensor node having at least one environmental sensor device for generating sensor data relating to the environment;
the method comprising the steps of:
a first sensor node of the plurality of sensor nodes encoding the sensor data generated on the first sensor node into a data stream using a rateless code, and transmitting the data stream to a second sensor node of the plurality of sensor nodes; and
the second sensor node receiving the data stream, and decoding the sensor data;
wherein sensor data generated by any of the sensor nodes is relayed from node-to-node to reach the at least one sink node;
wherein each sensor node divides the sensor data it generates into a plurality of blocks, and encodes the sensor data within the data stream as a series of data packets, the data packets comprising differing numbers of corresponding blocks,
the method comprising:
(a) for each of a plurality of communication links, each communication link being a communication link between a respective pair of said nodes, forming a respective measure of a quality of the communication link as an average, over a plurality of numbers of blocks, of a respective measure of an expected data transmission quality over the communication link of a data packet comprising that number of blocks; and
(b) modifying the data stream transmitted over at least one of the communication links of the plurality of communication links based on the respective measure of the quality of the communication link;
wherein the average is weighted by a probability value for each of the numbers of blocks, the probability value for each number of blocks being indicative of a proportion of data packets transmitted on the communication link which contain that number of data blocks.

US Pat. No. 9,930,842

BIOREACTOR

NANYANG TECHNOLOGICAL UNI...

1. A bioreactor for growing photoautotrophic organisms, the bioreactor comprising:a vessel configured to receive the photoautotrophic organisms, the vessel having a longitudinal axis, which a circumferential wall extends around said axis, wherein said circumferential wall is translucent so as to enable light to enter the vessel from outside the bioreactor for acting on the photoautotrophic organisms, wherein said vessel has a base for positioning said vessel on a surface and a top provided on an end opposite to the base when seen along said axis,
a device for providing an uneven distribution of light intensity of the light within said vessel along said axis, the uneven distribution of the light intensity comprising a distribution of the light intensity within said vessel that increases along the circumferential wall, towards the top of the vessel along said axis, wherein a circumference of said circumferential wall increases from said base towards said top,
one or more spaced apart dividers arranged to define a plurality of compartments within the vessel along said axis, wherein each divider has at least one orifice defined through the divider for fluid communication between the plurality of compartments, and
a plurality of draft tubes respectively arranged in the compartments of the plurality of compartments, wherein:
each compartment of the plurality of compartments comprises a respective draft tube of the plurality of draft tubes;
the respective draft tube is configured to be aligned with a respective divider such that a liquid medium and a gas that pass through the at least one orifice of the respective divider is distributed to the core of the draft tube, thereby inducing internal circulation of the liquid medium and the gas through the core of the draft tube, outwardly from the top of the draft tube and also inwardly into the interior of the draft tube from the bottom of the draft tube;
the draft tube is configured to impede light penetration to the interior of the draft tube.

US Pat. No. 10,011,694

POLYIMIDE-CARBON NANOTUBE COMPOSITE FILM

Nanyang Technological Uni...

1. A polyimide-carbon nanotube composite film comprisinga) a carbon nanotube, and
b) a polyimide obtainable by imidizing a poly(amic acid) having the following chemical formula

wherein n is an integer; and the poly(amic acid) has a weight-average molecular weight (Mw) of 1.97×105 g/mol with a polydispersity index of 1.96.

US Pat. No. 10,004,398

DEVICE FOR DETERMINING A CONDITION OF AN ORGAN AND METHOD OF OPERATING THE SAME

NANYANG TECHNOLOGICAL UNI...

1. A device for determining a condition of an organ of either a human or an animal, the device comprising:a first optical source;
a second optical source;
a detector;
a lens system;
a switching mechanism configured to switch between an optical examination mode and a Raman mode;
a processor coupled to the detector; and
one or more filters configured to generate one or more narrow-band Raman images from an image captured by the detector, wherein:
the lens system during the optical examination mode is configured to direct a first light emitted from the first optical source;
the lens system during the Raman mode is configured to direct a second light emitted from the second optical source;
the lens systems during the Raman mode is further configured to direct a third light to the detector;
the processor is configured to generate one or more reconstructed Raman images based on the one or more narrow Raman images, each of the one or more reconstructed Raman images corresponding to a respective wavelength of a plurality of wavelengths; and
the processor is further configured to generate a Raman spectrum at each pixel based on the one or more reconstructed Raman images.

US Pat. No. 9,995,794

METHODS FOR TESTING A BATTERY AND DEVICES CONFIGURED TO TEST A BATTERY

Nanyang Technological Uni...

1. A method for testing a battery, the method comprising:bringing the battery to a pre-determined voltage that is associated with at least one of a phase transition or a material change in at least one of an anode of the battery or a cathode of the battery;
changing a temperature of the battery by a pre-determined value;
determining a parameter of the battery at the pre-determined voltage and the temperature of the battery that is changed by the pre-determined value, the parameter of the battery comprising at least one of an entropy of the battery or an enthalpy of the battery; and
retroactively assessing a mode of ageing of the battery based on the determined parameter,
wherein the mode of ageing of the battery comprises information about at least one of a high voltage ageing, a high temperature ageing, or a long cycling ageing.

US Pat. No. 9,987,367

HYALURONIC ACID-BASED DRUG DELIVERY SYSTEMS

NANYANG TECHNOLOGICAL UNI...

1. A hyaluronic acid (HA) hydrogel comprising loaded liposomes dispersed thereinwherein
the loaded liposomes are loaded with one or more hydrophobic drugs;
the hyaluronic acid hydrogel is a covalently crosslinked hydrogel; and
the crosslinked hydrogel comprises at least one crosslinker selected from the group consisting of butylene glycol diglycidyl ether (BDG), butanediol diglycidyl ether (BDDGE) and poly(ethyleneglycol) diglycidyl ether (PEGDE),
wherein the HA may optionally be functionalized; and
wherein the incorporation of liposomes into the hydrogel retards the release of the drug and leads to an almost linear drug release profile over two weeks.

US Pat. No. 10,141,123

NANOFIBERS ELECTRODE AND SUPERCAPACITORS

Nanyang Technological Uni...

1. A method for synthesizing a free-standing flexible electrode, the method comprising:mixing a solution comprising molybdenum powder, vanadium powder and hydrogen peroxide to form a mixture comprising nanofibers represented by the formula of:
V0.07Mo0.93O3nH2O
wherein n is 1 or 2;
filtering the mixture to form an electrode comprising the nanofibers;
treating the electrode with an acidic solution;
contacting the acid-treated electrode with a monomer solution comprising monomers of a conductive polymer; and
polymerizing the monomers in a medium comprising an oxidizing agent to form the conductive polymer.

US Pat. No. 10,058,716

MICRO-EMULSIFIER FOR ARTERIAL THROMBUS REMOVAL

Nanyang Technological Uni...

1. A micro-emulsifier including a transducer, the micro-emulsifier comprising:actuating coils;
only one piezoelectric element comprising a cylinder with a hollow core, the piezoelectric element configured to contract and expand in the longitudinal axis of the transducer;
a horn at a proximal end of the piezoelectric element, the horn including a hollow tube that extends the entire length of the horn; and
a flexible transmission wire of solid metal for transmission of ultrasound waves able to be produced by the piezoelectric element, the ultrasound waves being able to be produced in a direction parallel to a longitudinal axis of the piezoelectric element and the horn, wherein the micro-emulsifier is configured for insertion of all of the micro-emulsifier into a human blood vessel for generating ultrasonic energy locally at a vicinity of a thrombus to ablate the thrombus, wherein the horn transmits and amplifies the ultrasonic energy, and wherein the transmission wire is integral with the horn.
US Pat. No. 10,005,936

PHOTOACTIVE BIOADHESIVE COMPOSITIONS

NANYANG TECHNOLOGICAL UNI...

1. A biocompatible polymer comprising a single strand of repeating units and up to 5,000 photoreactive groups covalently attached to said strand, wherein said polymer is comprised in a poly(lactide-co-glycolide) (PLGA) film, wherein the PLGA film is covered with said polymer, wherein said polymer has a molecular weight of up to 3 million Daltons, and wherein said photoreactive groups are derivatives of diazirine, wherein the polymer is a polyamide.

US Pat. No. 9,996,900

METHODS AND SYSTEMS FOR DEMOSAICING AN IMAGE

NANYANG TECHNOLOGICAL UNI...

1. A method of processing a two-dimensional image comprising an array of pixels, the pixels being composed of (i) a first set of pixels at each of which only a ground truth red color intensity value is defined, (ii) a second set of pixels at each of which only a ground truth blue color intensity value is defined and (iii) a third set of pixels at each of which only a ground truth green color intensity value is defined, to form a two-dimensional image comprising an array of pixels at each of which a color intensity value is defined for each of red, green and blue colors;the method including:
(a) applying at least one filter to the ground truth intensity values, to define, for each color, at least one respective interpolated color value at each of the pixels;
(b) for each of the colors, performing regression filtering using as guidance the interpolated color values for at least one of the other colors, to form an estimated color value;
(c) for each of the colors, obtaining residual values at the corresponding set of pixels as the difference between the estimated color value and the ground truth color value,
(d) for each of the colors, interpolating the residual values;
(e) for each of the colors, adding the interpolated residual values to the estimated color values to form a refined color value at each of the pixels; and
(f) repeating the set of steps (b)-(e) at least once;in each said repetition, said step (b) being performed for each color using as guidance the refined color values for at least one of the other colors generated during the preceding performance of step (e); and wherein each time step (e) is repeated, a mean difference value is calculated indicative of the difference averaged over the image between the refined color values which step (e) produces and the refined color values produced in the previous performance of step (e), the repetition of steps (b)-(e) being terminated if the difference value is below a threshold.

US Pat. No. 9,997,707

PEROVSKITE THIN FILMS HAVING LARGE CRYSTALLINE GRAINS

NANYANG TECHNOLOGICAL UNI...

1. A method for forming a perovskite thin film having an ABX3 crystalline structure, wherein the crystalline structure comprises an average grain size of more than 1 micron, the method comprising:forming via vacuum thermal evaporation a layer of a metal (II) halide (BX2) on a substrate;
depositing via spin coating a solution of an organic halide or a metal (I) halide (AX) on the BX2 layer; and
annealing the BX2 and AX layers to form the perovskite thin film, wherein A is CH3NH3+, CH3N2H2+, or Cs+, B is Pb2+, Sn2+, and X is Cl?, Br? or I?.

US Pat. No. 10,044,326

METHOD OF GENERATING A PULSE WIDTH MODULATION (PWM) SIGNAL FOR AN ANALOG AMPLIFIER, AND A RELATED PULSE WIDTH MODULATOR

Nanyang Technological Uni...

4. A pulse width modulator for generating a phase-adjusted pulse width modulation (PWM) signal for an analog amplifier, the amplifier arranged to receive an amplifier input signal, the pulse width modulator comprising:(i) a modulator input for receiving a modulator input signal, which is associated with the amplifier input signal,
(ii) a modulator for modulating a carrier with the modulator input signal to produce a PWM signal having a series of pulses, and
(iii) a pulse circuit for adjusting the pulses of the PWM signal to produce the phase-adjusted PWM signal, the phase-adjusted PWM signal including a series of phase-adjusted pulses with each phase-adjusted pulse defined by a pair of changing edges and a pulse center, the pulse center of each phase-adjusted pulse being fixed relative to a respective center of the carrier, and with one of the changing edges being synchronized to a triggering edge of the PWM signal.
US Pat. No. 10,041,886

MONOLAYER OF NANORODS ON A SUBSTRATE AND METHOD OF FORMING THE SAME

Nanyang Technological Uni...

1. A method of forming a monolayer of nanorods on a substrate, wherein the nanorods are at least substantially vertically aligned on the substrate, and wherein an edge-to-edge spacing between adjacent nanorods is equal to or less than 2 nm, the method comprising:providing a droplet of a solution comprising said nanorods and a surfactant on a substrate;
controlling the temperature and the evaporation of the solution such that the internal region of the droplet is kept at near equilibrium status to allow formation of the monolayer of nanorods on the substrate, wherein each of the nanorods is coated with the surfactant; and
removing the surfactant from each of the nanorods,
wherein removing the surfactant comprises carrying out an ultraviolet ozone treatment on the surfactant-coated nanorods.

US Pat. No. 10,127,016

MAGNETIC RANDOM NUMBER GENERATOR

NANYANG TECHNOLOGICAL UNI...

1. A magnetic random number generator comprising:a) a Hall cross structure comprising at least one magnetic nanowire with perpendicular magnetic anisotropy;
b) an in-plane pulsed current generator operable to generate stochastic nucleation of domain walls (DWs) in the Hall cross structure; and
c) a sensor configured to measure a parameter of the Hall cross structure upon DW nucleation, wherein said parameter has a value representing a random number.

US Pat. No. 10,187,084

METHOD OF ENCODING DATA AND DATA STORAGE SYSTEM

NANYANG TECHNOLOGICAL UNI...

1. A method of encoding data, the method comprising:providing a set of replica nodes, wherein each replica node of the set of replica nodes stores replica data identical to original data stored in a corresponding original node of a set of original nodes;
receiving original data at each replica node of the set of replica nodes, wherein the received original data is transmitted from the corresponding original node of a different replica node of the set of replica nodes;
generating a first result at each replica node, based on the replica data stored therein and the received original data; and
generating a second result at each replica node, based on the replica data stored therein and the first result from a different replica node of the set of replica nodes; and
replacing the replica data in each replica node with the second result generated at the respective replica node, wherein the set of original nodes and the set of replica nodes store erasure coded data after the replacing of the replica data in each replica node with the second result generated at the respective replica node.

US Pat. No. 10,160,803

ANGIOPOIETIN-RELATED PROTEIN 4 (CANGPTL4) AS A DIAGNOSTIC BIOMARKER FOR ACUTE LUNG DAMAGE

National University of Si...

1. A method to monitor an acute inflammation of the lung in response to a microbial infection in a subject, comprising:i) providing an isolated biological sample from the subject, wherein the sample is a lung tissue sample or bronchial lavage fluid sample;
ii) forming a preparation comprising said sample and an antibody that specifically binds an amino acid sequence set forth as SEQ ID NO: 3 or SEQ ID NO: 4 in a carboxyl-terminal fragment of angiopoietin-related protein 4 (cANGPTL4) in a polypeptide in said sample to form an antibody/polypeptide complex;
iii) detecting the complex in the sample to determine the level of expression of the polypeptide in said sample; and
iv) comparing the level of expression of said polypeptide with a normal matched control;
wherein an increase in the level of expression of said polypeptide compared to the control identifies the subject as having acute inflammation of the lung in response to a microbial infection.

US Pat. No. 10,141,837

DEVICE AND METHOD FOR ENERGY HARVESTING USING A SELF-OSCILLATING POWER-ON-RESET START-UP CIRCUIT WITH AUTO-DISABLING FUNCTION

Agency for Science, Techn...

1. A device for energy harvesting, comprising:a start-up circuit including a power-on reset circuit for generating a sequence of pulses to control self-oscillation of the start-up circuit, an auxiliary voltage boost circuit coupled to the power-on reset circuit and an input of the start-up circuit for boosting an input voltage of the start-up circuit, and a feedback loop including an energy source, the auxiliary voltage boost circuit and the power-on reset circuit such that the start-up circuit generates the sequence of pulses for self-oscillation through the feedback loop for initial boosting of the input voltage from the energy source;
a main boost circuit for boosting the input voltage during a steady state phase;
a clock generator circuit for generating clock signals which control voltage boosting of the main boost circuit during the steady state phase; and
a switching circuit coupled to the start-up circuit, the main boost circuit and the clock generator circuit for switching powering of the clock generator circuit between the start-up circuit and the main boost circuit such that the clock generator circuit is powered by only one of the start-up circuit and the main boost circuit at any point in time.

US Pat. No. 10,119,036

PROCESS FOR THE FORMATION OF METAL OXIDE NANOPARTICLES COATING OF A SOLID SUBSTRATE

YISSUM RESEARCH DEVELOPME...

1. A process for forming a coating comprising metal oxide or mixed metal oxide nanoparticles of one or more metals selected from the group consisting of tin, antimony, germanium and tellurium on a solid substrate, comprising:providing a basic metal-containing solution containing at least one metal selected from said group and hydrogen peroxide, and contacting said basic metal-containing solution with a solid substrate having oxygen-containing chemically reactive groups on its surface, wherein said solid substrate having oxygen-containing chemically reactive groups on its surface is contacted with said basic metal-containing solution and hydrogen peroxide solution under conditions allowing formation of peroxynanoparticle coating on the solid substrate upon addition of an antisolvent capable of inducing a precipitation of the peroxynanoparticle coating, wherein peroxynanoparticles present in the peroxynanoparticle coating have a diameter of less than 10 nm, with no agglomeration occurring in the basic metal-containing solution, as is evident by scanning electron microscopy or transmission electron microscopy; and
heat treating the peroxynanoparticle coating to obtain a metal oxide or mixed metal oxide nanoparticle coating layer of less than 20 nm; wherein the heat treating comprises calcining the peroxynanoparticle coating on the solid substrate at a temperature of 300-1000° C.

US Pat. No. 10,114,024

BIOMOLECULE-GRAPHENE QUANTUM DOT CONJUGATES AND USE THEREOF

Nanyang Technological Uni...

1. A method to form an insulin-GQD conjugate, wherein a single biomolecule of insulin is coupled to a single graphene quantum dot (GQD), the method comprising:contacting a solution containing GQD with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), wherein the GQD comprises one or more carboxyl groups on an edge of the GQD; and wherein 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride reacts with the one or more carboxyl groups to form an O-acylisourea intermediate compound;
contacting the O-acylisourea intermediate compound with N-hydroxysuccinimide (NHS), to provide an NHS ester-modified GQD; and
contacting the NHS ester-modified GQD with biomolecules of insulin to form the insulin-GQD conjugate, wherein the insulin-GQD conjugate is suitable for imaging an interior of a living cell.

US Pat. No. 10,180,564

METHODS AND SYSTEMS FOR TRANSPORT-OF-INTENSITY IMAGING

NANYANG TECHNOLOGICAL UNI...

1. An apparatus for imaging a specimen, the apparatus comprising:an microscope system for forming a magnified image of a portion of the specimen;
an image capture device for capturing an image;
an optical relay system located between the microscope system and the image capture device;
the optical relay system being configured to receive the magnified image of the portion of the specimen and comprising a control element for modifying at least one beam of light passing through the optical relay system to vary a plane within the specimen which is in focus in the image captured by the image capture device; and
a computer unit;
whereby the image capture device is operative to capture multiple images in which different respective planes of the specimen are put in focus by the optical relay system, and wherein the computer unit is arranged to use the multiple captured images at different respective focal planes in the specimen to generate a phase map of the portion of the specimen, indicating the degree to which respective parts of the specimen modify the phase of light transmitted to the specimen by the microscope system,
wherein the generation of the phase map includes:
generating intensity derivative values for respective portions of the specimen labeled by variable r, the intensity derivative values indicating, for each said respective portion of the specimen, a derivative of the intensity in a direction in which light of the microscope system impinges on the specimen;
forming a first Poisson equation using the intensity derivative values;
solving the Poisson equation to generate an intermediate function ?(r);
forming a derivative of the intermediate function; and
solving a second Poisson equation involving the intermediate function to obtain the phase map;
wherein the multiple images consist of 2n+1 images with equal pairwise separation of ?z, where n is a positive integer;
said intensity derivative being derived as a summation over the images of a function of each respective image multiplied by a coefficient obtained using a Gram polynomial, and a respective said phase map being generated from respective pairs of the multiple images;
subjecting each phase map to a respective band-pass operation; and
forming a combined phase map from the results of the band-pass operations.

US Pat. No. 10,179,927

ELECTROCHEMICAL DETECTION OF MICROORGANISMS

Nanyang Technological Uni...

1. A method for determining the presence of a microorganism in a sample using an electrochemically active reporter, wherein the method comprises(a) contacting the sample with an electrochemically active reporter,
wherein the electrochemically active reporter is a conjugate comprising a sugar moiety and a redox active reporter moiety that are covalently linked such that the covalent bond can be enzymatically cleaved in the presence of the microorganism by an enzyme expressed by the microorganism, wherein the redox active reporter moiety is selected from the group consisting of compounds of formula (I) and resorufin

wherein A is an aryl or heteroaryl ring of formula (II) or (III):

each of R1-R6 is independently selected from the group consisting of H, NR7R, C1-10 alkyl, OR7, or R1 and R2 combine to form together with the carbon atoms to which they are attached a 5-6 membered alicyclic or aryl ring, wherein the alicyclic or aryl ring is substituted or unsubstituted, and if substituted the substituents are one or more groups selected from NR7R8, C1-10 alkyl, and OR7;
X is N or S+;
R7 and R8 are independently selected from the group consisting of H, C(O)—R9, C1-10 Alkyl;
R9 is C1-10 Alkyl,
under conditions that allow enzymatic cleavage of the covalent bond between the sugar moiety and the redox active reporter moiety and reduction of the redox active report moiety in the presence of the microorganism;
(b) electrochemically determining the released redox active reporter moiety; and
(c) determining the presence of the microorganism and, optionally, number of the microorganisms in the sample based on the determined released redox active reporter moiety.

US Pat. No. 10,151,858

DEVICE INCLUDING HALIDE PEROVSKITE STRUCTURE, METHODS OF FORMING AND OPERATING THE SAME

NANYANG TECHNOLOGICAL UNI...

1. A device for providing a first optical light of a first wavelength and a second optical light of a second wavelength, the device comprising:a halide perovskite film comprising a first pattern and a second pattern on a surface on the halide perovskite film, the second pattern different from the first pattern, so that the first pattern is configured to provide the first optical light of the first wavelength and the second pattern is configured to provide the second optical light of a second wavelength different from the first wavelength, upon a light incident on the first pattern and the second pattern;
wherein the first pattern is configured to provide the first optical light by absorbing the light to radiate the first optical light;
wherein the second pattern is configured to provide the second optical light by absorbing the light to radiate the second optical light; and
wherein the halide perovskite film comprises a halide perovskite material.

US Pat. No. 10,121,822

LIGHT-EMITTING DEVICE AND METHOD OF FORMING THE SAME

NANYANG TECHNOLOGICAL UNI...

1. A light-emitting device comprising:an active layer;
a first semiconductor layer of a first conductivity type, the first semiconductor layer in physical contact with the active layer;
a second semiconductor layer of a second conductivity type, the second semiconductor layer in physical contact with the active layer and opposite the first semiconductor layer;
a first electrode in physical contact with a first lateral side of the first semiconductor layer;
a second electrode in physical contact with a second lateral side of the first semiconductor layer, the second lateral side of the first semiconductor layer being different from the first lateral side of the first semiconductor layer; and
a third electrode in physical contact with the second semiconductor layer, wherein the first electrode and the second electrode are physically isolated from a surface side of the first semiconductor layer joining the first lateral side and the second lateral side, the surface side being configured to transmit light generated by the light-emitting device.

US Pat. No. 10,251,238

ELECTROLUMINESCENT DEVICE AND METHOD OF FORMING THE SAME

NANYANG TECHNOLOGICAL UNI...

1. An electroluminescent device comprising:a first contact structure, the first contact structure comprising an ionic conductor layer and an electrode in contact with the ionic conductor layer;
a second contact structure; and
an emission layer between the first contact structure and the second contact structure; wherein:
the emission layer is configured to emit light when an alternating voltage is applied between the first contact structure and the second contact structure;
the emission layer comprises an elastomer and one or more electroluminescent elements embedded in the elastomer;
the electrode of the first contact structure and the ionic conductor layer form an interface having a capacitive value higher than a capacitive value of the emission layer; and
the emission layer is in contact with ionic conductor layer.
US Pat. No. 10,236,466

ORGANIC LIGHT EMITTING DEVICE

NANYANG TECHNOLOGICAL UNI...

1. An organic light emitting device comprising:a substrate comprising glass;
an indium tin oxide (ITO) layer arranged over the substrate;
a molybdenum trioxide (MoO3) layer arranged over the indium tin oxide (ITO) layer;
a first light emitting unit arranged over the molybdenum trioxide (MoO3) layer;
a second light emitting unit; and
a charge generation layer;
wherein the second light emitting unit is stacked over the first light emitting unit and is connected to the first light emitting unit by means of the charge generation layer; and
wherein the charge generation layer comprises:
an electron transport layer comprising Bathophenanthroline (Bphen) doped with caesium carbonate (Cs2CO3);
a transition metal oxide layer, the transition metal oxide layer comprising molybdenum trioxide (MoO3), arranged over the electron transport layer of the charge generation layer; and
a diffusion suppressing layer arranged between the electron transport layer of the charge generation layer and the transition metal oxide layer of the charge generation layer to separate the electron transport layer of the charge generation layer from the transition metal oxide layer of the charge generation layer;
wherein the diffusion suppressing layer is formed of Buckminsterfullerene;
wherein the first light emitting unit comprises:
a hole transport layer comprising ninhydrin petroleum ether (NPB); and
an electron transport layer, the electron transport layer comprising Tris(8-hydroxyquinolinato)aluminium (Alq3) arranged over the hole transport layer of the first light emitting unit;
wherein the second light emitting unit comprises:
a hole transport layer comprising ninhydrin petroleum ether (NPB); and
an electron transport layer, the first electron transport layer comprising Tris(8-hydroxyquinolinato)aluminium (Alq3) arranged over the hole transport layer of the second light emitting unit; and
a cathode over the second light emitting unit, the cathode comprising caesium carbonate and aluminium (Cs2CO3/Al).
US Pat. No. 10,226,479

METHOD OF INHIBITING QUORUM SENSING IN PSEUDOMONAS AERUGINOSA

NANYANG TECHNOLOGICAL UNI...

20. A method for the treatment of biofilm and/or for inhibiting biofilm formation of a component comprising a medical device, a personal hygiene article, a toiletry, a cosmetic, a disinfectant, a cleaning solution in a water treatment, or in a distribution system, the method comprising inhibiting quorum sensing in Pseudomonas aeruginosa, comprising contacting Pseudomonas aeruginosa with a gold(I) thiolate complex in an amount effective to inhibit quorum sensing in the Pseudomonas aeruginosa by contacting the component with the gold(I) thiolate complex.

US Pat. No. 10,213,122

SYSTEMS AND METHODS FOR PEDAL REVASCULARIZATION ASSESSMENT

Nanyang Technological Uni...

1. A system for assessment of peripheral blood flow characteristics in deep tissue, the system comprising:a support structure configured to be positioned onto an external body part of a patient; at least one diffuse optical flow (DOF) sensor carried by the support structure and configured to be positioned in optical communication with a skin surface of the patient, the at least one DOF sensor comprising a return optical conduit, and at least one input optical fiber comprising an end configured to be positioned proximate the skin surface of the patient, the at least one input optical fiber in optical communication with a coherent laser light source;
a photodetector operably connected to the at least one DOF sensor;
a processor configured to analyze data from the at least one DOF sensor to determine blood flow characteristics at a location near the at least one DOF sensor when the support structure is positioned onto the external body part of the patient, the processor configured to determine blood flow characteristics in blood vessels of the patient by determining a spatial speckle contrast ratio (Ks) or a temporal speckle contrast ratio (Kt) and determining 1/Ks2 or 1/Kt2 from intensity fluctuations, and correlating 1/Ks2 or 1/Kt2 values with blood flow; and
a display configured to provide feedback indicative of the blood flow characteristics determined by the processor,
wherein the at least one DOF sensor is configured to capture light scattered diffusively into tissue and transmitted at a depth of penetration of between 5 mm and 50 mm.

US Pat. No. 10,205,207

IONIC LIQUID ELECTROLYTE AND FLUORINATED CARBON ELECTRODE

NANYANG TECHNOLOGICAL UNI...

1. An electrolyte for a metal air battery, comprising:a solvent comprising:
a base solvent, wherein the base solvent is an ionic liquid;
a bridging solvent, wherein the bridging solvent is an organic solvent; and
a solute consisting essentially of:
an electron neutral fluorinated carbon compound; and
a metal salt selected from the group consisting of LiClO4, LiBr, LiI, LiAlCl4, and combinations thereof,
wherein the electron neutral fluorinated carbon compound has a general formula R1-(CnF2n)—R2, wherein each of R1and R2 is independently F, H, C1-C5 alkyl, C1-C5 alkoxy, or CnF2p+1, and 1?n?20, and 1?p?20.

US Pat. No. 10,173,149

METHODS FOR SEPARATING CARBON NANOTUBES

NANYANG TECHNOLOGICAL UNI...

1. A method for separating semiconducting carbon nanotubes from metallic carbon nanotubes, the method comprising the steps of:(a) dispersing a mixture of the semiconducting carbon nanotubes and the metallic carbon nanotubes in a starting dispersing agent having a pH of 7 or less to form a carbon nanotube dispersion;
(b) passing the carbon nanotube dispersion over a negatively charged material, wherein the carbon nanotube dispersion comprises a mixture of the semiconducting carbon nanotubes and the metallic carbon nanotubes;
(c) passing an eluent solution through the negatively charged material after (b), wherein the eluent solution comprises a first dispersing agent without a net charge; and
(d) collecting an eluate enriched with semiconducting carbon nanotubes.

US Pat. No. 10,166,513

SPACER FOR A MEMBRANE MODULE

NANYANG TECHNOLOGICAL UNI...

1. A spacer for a membrane module, the spacer comprising:a plurality of first filaments defining a plurality of fluid flow channels, in use the plurality of fluid flow channels being adjacent a membrane of the membrane module; and
a plurality of second filaments provided on the plurality of first filaments and extending into the fluid flow channels, the second filaments moveable relative to the first filaments in response to an external stimulus during flow of fluid in the fluid flow channels.