US Pat. No. 9,484,940

USING HIGH FREQUENCY CRYSTAL FROM EXTERNAL MODULE TO TRIM REAL TIME CLOCK

Medtronic, Inc., Minneap...

1. A medical system, comprising:
an external device having a signal generator for generating a remote signal; and
an implantable medical device, including:
a first input for receiving the remote signal;
a local low-power clock generator configured to generate a first clock signal;
a clocking circuit coupled to the first input and the local low-power clock generator, wherein the clocking circuit is configured
to:

detect a frequency of the remote signal,
compute a weighting value based on the frequency of the remote signal and a desired frequency of the first clock signal,
compare an alignment of a cycle edge of the first clock signal to a cycle edge of the remote signal during a first time interval,
wherein the cycle edge of the remote signal that is compared to the first clock signal is selected based on the computed weighting
value, and

generate a calibration factor for calibrating an operation of the local low-power clock generator based on the alignment comparison
of the cycle edge of the remote signal relative to the cycle edge of the first clock signal.

US Pat. No. 9,289,145

IDENTIFICATION OF ABNORMAL CARDIAC SUBSTRATE DURING LEFT-VENTRICULAR PACING

Medtronic, Inc., Minneap...

1. A system for identifying abnormal cardiac substrate, the system comprising:
at least one implantable left-ventricular (LV) lead comprising a plurality of electrodes, wherein the plurality of electrodes
includes at least one bipolar electrode pair configured to sense a LV bipolar cardiac electrogram signal of LV tissue proximate
the bipolar electrode pair;

a signal generator configured to deliver cardiac pacing pulses to a left ventricle via at least one electrode of the plurality
of electrodes of the at least one LV lead,

wherein the bipolar electrode pair does not include the at least one electrode of the plurality of electrodes via which the
signal generator is configured to deliver cardiac pacing pulses to the left ventricle, and

wherein a distance from the bipolar electrode pair to the at least one electrode of the plurality of electrodes via which
the signal generator is configured to deliver cardiac pacing pulses to the left ventricle is greater than or equal to approximately
ten millimeters; and

a cardiac tissue analysis module configured to:
determine an amplitude of a depolarization within the LV bipolar cardiac electrogram signal, the depolarization resulting
from the delivery of cardiac pacing pulses to the left ventricle, wherein the amplitude indicates whether the LV tissue proximate
the bipolar electrode pair comprises abnormal cardiac substrate; and

provide an indication of whether the LV tissue proximate the bipolar electrode pair comprises abnormal cardiac substrate based
on the amplitude.

US Pat. No. 9,364,280

METHODS AND APPARATUS FOR PULSED ELECTRIC FIELD NEUROMODULATION VIA AN INTRA-TO-EXTRAVASCULAR APPROACH

Medtronic Ardian Luxembou...

1. An apparatus for electric field neuromodulation, comprising:
an electric field generator;
an elongated element configured to be moved within a vascular structure of a patient;
at least one electrode electrically coupled to the field generator and having an intravascular portion associated with the
elongated element and having an extravascular portion configured to be passed through a wall of the vascular structure; and

an actuator associated with the at least one electrode and being configured to move the electrode between a first position
in which the extravascular portion of the electrode is within the vascular structure and a second position in which the extravascular
portion of the electrode is located at an extravascular location for extravascular delivery of an electric field.

US Pat. No. 9,445,797

PERCUTANEOUS ATRIAL AND VENTRICULAR SEPTAL DEFECT CLOSURE DEVICE

Medtronic, Inc., Minneap...

1. A medical device for closing an anatomical aperture comprising:
a plug body having a proximal end, a distal end, and a longitudinal axis, the plug body having a wall with an exterior surface
and an interior surface that defines an interior lumen; and

a seal located within the interior lumen;
a distal loop having a first portion, a second portion and a middle portion extending between the first and second portions,
the middle portion of the distal loop extending through the wall of the plug body between the exterior surface and the interior
surface of the wall proximate to the distal end of the plug body, wherein the first portion of the distal loop radially extends
away from the exterior surface of the wall of the plug body in a first direction and the second portion of the distal loop
radially extends away from the exterior surface of the wall of the plug body in a second direction, wherein the second direction
is opposite of the first direction relative to the longitudinal axis of the plug body; and

a proximal loop having a first portion, a second portion and a middle portion extending between the first and second portions,
the middle portion of the proximal loop extending through the wall of the plug body between the exterior surface and the interior
surface of the wall proximate to the proximal end of the plug body, wherein the first portion of the proximal loop radially
extends away from the exterior surface of the wall of the plug body in the first direction and the second portion of the proximal
loop radially extends away from the exterior surface of the wall of the plug body in the second direction,

wherein the first portions of the proximal and distal loops are angled toward each other and wherein the second portions of
the proximal and distal loops are angled toward each other, and

wherein a first end of the first portion of the proximal loop crosses under a first end of the first portion of the distal
loop, and wherein a second end of the second section of the proximal loop crosses over a second end of the second section
of the distal loop, when the loops are in an unconstrained configuration.

US Pat. No. 9,439,150

CONTROL OF SPECTRAL AGRESSORS IN A PHYSIOLOGICAL SIGNAL MONTORING DEVICE

Medtronic, Inc., Minneap...

1. A signal monitoring device comprising:
a power source;
a power distribution network electrically coupled to the power source;
an analog-to-digital converter electrically coupled to the power distribution network and configured to sample an input signal
to produce a sampled signal; and

a processor electrically coupled to the power distribution network and configured to cycle between an algorithm processing
mode and a sleep mode based on a sleep cycle rate,

wherein the sleep cycle rate causes spectral interference to propagate through the power distribution network and into the
sampled signal via the analog-to-digital converter, and

wherein the sleep cycle rate further causes the spectral interference that is generated due to the sleep cycle rate to occur
in the sampled signal at one or more frequencies that are outside of a target frequency band of the sampled signal.

US Pat. No. 9,510,777

MONITORING OF NEUROMODULATION USING BIOMARKERS

Medtronic Ardian Luxembou...

1. A method of determining biomarker activity in a human patient, the method comprising:
transluminally positioning a first energy delivery element of a catheter within a target blood vessel of the patient and adjacent
to target neural fibers;

at least partially ablating the target neural fibers via the first energy delivery element;
capturing a plurality of at least one type of biomarker in a capture compartment of the catheter, wherein the biomarker(s)
are secreted as a result of the ablation procedure;

sequestering the plurality of the at least one type of biomarker in the capture compartment to concentrate the biomarker(s);
binding the biomarker(s) to at least one immobilized capture agent disposed on an inner surface of the capture compartment;
and

detecting a concentration of the biomarker(s), wherein the concentration corresponds, at least in part, to a degree of ablation
of the target neural fibers.

US Pat. No. 9,095,321

CRYOTHERAPEUTIC DEVICES HAVING INTEGRAL MULTI-HELICAL BALLOONS AND METHODS OF MAKING THE SAME

Medtronic Ardian Luxembou...

1. A method of forming a balloon from an extruded integral shaft having a plurality of lumens along the shaft, the plurality
of lumens including at least a first lumen and a second lumen, the method comprising:
positioning a distal portion of the shaft in a mold configured to define an outer surface of the balloon;
clamping a first end region of the distal portion with the mold;
rotating the mold relative to the shaft thereby forming a twisted distal portion of the shaft; and
forming the balloon along the twisted distal portion, wherein the balloon is configured to deliver therapeutically effective
cryogenic cooling to a treatment site.

US Pat. No. 9,232,994

STENTED PROSTHETIC HEART VALVE AND METHODS FOR MAKING

Medtronic Vascular Galway...

1. A stented prosthetic valve comprising:
a stent including a plurality of struts combining to define a tubular body, the plurality of struts forming first and second
strut segments;

a plurality of leaflets mounted to the stent, a first one of the leaflets being provided as part of a first leaflet layer
having a first tab region; and

a first coupling apparatus for connecting the first leaflet layer to the stent, the first coupling apparatus including:
a first backing layer,
a guide plate apart from the stent,
a pin apart from the stent,
wherein a portion of the backing layer and the first tab region are captured between the guide plate and the pin;
wherein the backing layer is attached to at least one of the first and second strut segments to mount the first leaflet to
the stent;

wherein the backing layer includes a base and a first flap projecting from the base, and further wherein the base abuts the
first tab region at an interface established between the guide plate and the pin, and even further wherein the first flap
projects from the interface and is wrapped about the first strut segment;

wherein the backing layer further includes a second flap projecting from the base, and further wherein the second flap is
wrapped about the second strut segment.

US Pat. No. 9,326,817

METHODS FOR TREATING HEART ARRHYTHMIA

Medtronic Ardian Luxembou...

1. A method for treating heart arrhythmia in a patient in need thereof, the method comprising:
introducing a modulation instrument proximate a first neural fiber that contributes to renal function of a first kidney of
the patient, the modulation instrument comprising a catheter comprising an inflatable balloon and electrodes attached to the
inflatable balloon; and

delivering energy to the first neural fiber via the modulation instrument in order to modulate a function of the first neural
fiber, thereby systemically reducing sympathetic tone in the patient.

US Pat. No. 9,227,088

METHODS OF USING HIGH INTENSITY FOCUSED ULTRASOUND TO FORM AN ABLATED TISSUE AREA CONTAINING A PLURALITY OF LESIONS

Medtronic, Inc., Minneap...

1. A trans-esophageal ablation device for ablating tissue within a patient, comprising:
a flexible, elongate portion adapted to be guided within said patient;
a source of energy;
a two-dimensional array of transducer elements operatively coupled to said elongate portion and said source of energy, said
two-dimensional array of transducer elements configured to deliver high intensity focused ultrasound (HIFU) energy to a focus
zone within said patient and which may also deliver HIFU energy to a grating lobe;

wherein each of said transducer elements are selectively actuatable to allow for electronic steering of said HIFU energy;
and

wherein said transducer elements have a taper wherein said transducer elements positioned more centrally in said two-dimensional
array are larger than said transducer elements positioned more peripherally in said two-dimensional array.

US Pat. No. 9,095,319

SUTURING DEVICE AND METHOD FOR SEALING AN OPENING IN A BLOOD VESSEL OR OTHER BIOLOGICAL STRUCTURE

Medtronic Vascular, Inc.,...

18. A suturing device for positioning a suture in situ, comprising:
a handle having a first actuation mechanism and a second actuation mechanism, wherein the second actuation mechanism includes
a suture holder and a needle holder disposed within the handle;

an elongated body defining at least one lumen there through and coupled to a distal end of the handle;
a suture snag disposed at a distal end of the elongated body, wherein the first actuation mechanism moves the suture snag
between a deployed position in which two distal arm portions thereof radially extend away from the elongated body and a retracted
position in which the two distal arm portions are disposed within the elongated body;

a pair of needles extending through the handle and through the elongated body, each needle including a distal end configured
to penetrate through a vessel wall, wherein the pair of needles is coupled to the needle holder and wherein the second actuation
mechanism moves the pair of needles to a deployed position in which the pair of needles distally extend away from the distal
end of the elongated body and a retracted position in which the pair of needles is disposed within the elongated body; and

a pair of sutures slidingly disposed through the pair of needles, wherein the sutures are coupled to the suture holder when
the needles are in their deployed position and are disengaged from the suture holder when the needles are in their retracted
position and wherein the second actuation mechanism moves the pair of sutures relative to the pair of needles from a loaded
position in which each first end of each suture is disposed within its respective needle to a deployed position in which each
first end of each suture extends distally beyond the distal end of its respective needle.

US Pat. No. 9,320,591

DEVICES, SYSTEMS, AND METHODS FOR PROSTHESIS DELIVERY AND IMPLANTATION, INCLUDING THE USE OF A FASTENER TOOL

Medtronic Vascular, Inc.,...

1. A fastener applier for securing a prosthesis, the fastener applier comprising:
a handle assembly positioned at the caudal end of the fastener applier;
a fastener applier shaft coupled to the handle assembly, the fastener applier shaft comprising a cephalad end;
a fastener driver for advancing a helical fastener into the prosthesis and tissue, the fastener driver coupled to the fastener
applier shaft at the cephalad end of the fastener applier shaft and comprising a housing, the fastener driver housing comprising
an internally threaded portion and an unthreaded portion, the unthreaded portion providing an area where the helical fastener
can be rotated but not advanced off of the fastener driver, the advancement off of the fastener driver only taking place if
the fastener has been previously engaged in tissue or the prosthesis, wherein the handle assembly comprises a motion control
assembly that controls motion of the fastener within the fastener driver, wherein the motion control assembly comprises a
forward control function and a reverse control function.

US Pat. No. 9,226,995

BIODEGRADABLE MEDICAL DEVICE WITH HYDROXYAPATITE FILAMENTS AND BIODEGRADABLE POLYMER FIBERS

Medtronic Vascular, Inc.,...

1. A stent comprising a hydroxyapatite fiber, the hydroxyapatite fiber comprising:
biodegradable polymer filaments coaxially aligned along a length of the hydroxyapatite fiber; and
hydroxyapatite particles bound to the biodegradable polymer filaments.

US Pat. No. 9,272,144

LEAD ELECTRODE FOR USE IN AN MRI-SAFE IMPLANTABLE MEDICAL DEVICE

MEDTRONIC, INC., Minneap...

1. An implantable stimulation system for generating and delivering therapy to a patient, said stimulation system comprising:
a stimulator for generating the therapy;
a conductive stimulation lead having a proximal end electrically coupled to said stimulator;
a stimulation electrode positioned proximate a distal end of said stimulation lead; and
impedance matching means electrically coupled to said lead for substantially matching the impedance of said stimulator to
the characteristic impedance of said lead, the impedance matching means comprising a matching resistor, a variable impedance
circuit, and components that monitor a voltage across the matching resistor and vary an impedance of the variable impedance
circuit to maintain the voltage across the matching resistor at a maximum.

US Pat. No. 9,192,692

CHITOSAN STENTING PASTE

Medtronic Xomed, INc., J...

1. A sinus stent paste comprising a water-soluble chitosan or derivative thereof and an osmolality reducing agent in a phosphate-containing
solution to provide an opaque paste at room temperature containing at least 5 wt. % of the water-soluble chitosan or derivative
thereof based on the total paste weight and having a pH of at least 4, a viscosity of about 1 to about 15 Pa·s., an osmolality
of about 270 to about 2000 mOsm/kg, and a residence time of at least 1 day, wherein the osmolality reducing agent does not
crosslink with the water-soluble chitosan.

US Pat. No. 9,333,294

INSERTION DEVICE

MEDTRONIC MINIMED, INC., ...

1. A method for covering an insertion needle, comprising:
inserting a cannula into the skin of a patient with an insertion device, wherein the insertion device includes:
a hub removably attachable to a base of a cannula housing of an infusion set, said hub including a handle part and a guard
part, wherein said handle part has a vertical portion and a horizontal portion; and

a needle attached to the hub, wherein, for the entirety of its travel, the guard part is configured to slide along an outer
surface of the handle part according to a direction pulled to cover the needle, said direction being parallel to the needle's
longitudinal axis and perpendicular to the handle part's horizontal portion;

removing the insertion device from the cannula housing; and
sliding the guard part along the handle part in said direction parallel to the needle's longitudinal axis and perpendicular
to the handle part's horizontal portion so as to cover the needle with the guard part.

US Pat. No. 9,271,708

SUTURING DEVICE AND METHOD FOR SEALING AN OPENING IN A BLOOD VESSEL OR OTHER BIOLOGICAL STRUCTURE

Medtronic Vascular, Inc.,...

16. A method of positioning a suture at an arteriotomy of a vessel wall of a vessel, wherein the method includes the steps
of:
positioning a distal end of a suturing device through the arteriotomy, wherein the suturing device includes a handle, an elongated
body coupled to a distal end of the handle, and a shaft slidingly disposed within the handle and the elongated body, wherein
an inflatable balloon is mounted on a distal portion of the shaft and is in a retracted configuration in which the balloon
is disposed within the elongated body;

distally advancing the shaft of the suturing device to position the inflatable balloon within the vessel;
inflating the balloon to a deployed configuration within the vessel, wherein the balloon radially expands and extends away
from the elongated body;

distally extending at least one pair of needles of the suturing device from a loaded position in which the at least one pair
of needles is disposed within the elongated body to a deployed position in which the at least one pair of needles distally
extend from a distal end of the elongated body and penetrate through the vessel wall and through the inflated balloon, wherein
a suture is slidingly disposed through the lumen of each needle and each suture is concurrently carried with its respective
needle during the step of distally extending the at least one pair of needles to the deployed position.

US Pat. No. 9,149,357

HEART VALVE ASSEMBLIES

Medtronic CV Luxembourg S...

1. An implantable prosthetic valve assembly comprising:
a radially expandable frame comprising,
an inflow portion that is configured, in an expanded state, to bear against a native cardiac annulus in a manner so as to
resist migration,

a second portion extending from the inflow portion in an outflow direction, and configured, in an expanded state, not to bear
against the native cardiac annulus and an ascending aorta,

an outflow portion extending from the second portion in the outflow direction, and configured, in an expanded state, to bear
against the ascending aorta above a coronary ostia, and

a plurality of connection rods extending between the second portion and the outflow portion, wherein in an expanded state
the plurality of connection rods are arranged uniformly on a periphery of the frame; and

a prosthetic valve coupled to the frame substantially within the second portion.

US Pat. No. 9,308,038

LARGE AREA CRYOABLATION CATHETER WITH MULTI-GEOMETRY TIP ECG/CRYO MAPPING CAPABILITIES

Medtronic CryoCath LP, T...

1. A medical device, comprising:
an ablation element;
a thermally insulative sheath disposed within the ablation element;
a fluid injection tube disposed within a portion of the thermally insulative sheath; and
the ablation element passively transitioning from a substantially linear geometric configuration to a substantially circular
geometric configuration as the sheath is retracted proximally from a first position in which the sheath substantially encloses
the fluid injection tube to a second position in which a portion of the fluid injection tube extends a distance away from
the sheath, at least a portion of the fluid injection tube being biased in the substantially circular geometric configuration.

US Pat. No. 9,237,961

STENT DELIVERY SYSTEM FOR DETECTING WALL APPOSITION OF THE STENT DURING DEPLOYMENT

Medtronic Vascular, Inc.,...

1. A stent delivery and apposition detecting system comprising:
a balloon catheter having a balloon mounted at the distal end thereof with a stent coupled to an intermediate portion of the
balloon; and

at least one electrode pair including a first electrode and a second electrode of dissimilar metals mounted on the balloon
such that the first electrode is mounted proximal to the stent and the second electrode is mounted distal to the stent, wherein
the stent delivery and apposition detecting system uses an electrochemical cell created by the electrode pair to detect when
the stent achieves apposition with a vessel wall during deployment.

US Pat. No. 9,072,476

FLEXIBLE SENSOR APPARATUS

MEDTRONIC MINIMED, INC., ...

1. A sensor apparatus comprising:
a flexible analyte sensor; and
a flexible mounting base to carry the flexible analyte sensor including:
a flexible adhesive layer to removably attach to a skin surface;
a housing disposed on the adhesive layer to receive the flexible analyte sensor, said housing including a base layer and a
plurality of sidewalls depending from said base layer; and

a one-piece outer flexible layer that is entirely separate from the housing and from the flexible adhesive layer, wherein,
once assembled, the flexible adhesive layer and the outer flexible layer enclose therebetween the entirety of the housing,
including said plurality of sidewalls.

US Pat. No. 9,226,689

FLEXIBLE CIRCUIT SHEET

MEDTRONIC XOMED, INC., J...

1. A surgical instrument, comprising:
an elongated body having a proximal end and a distal end;
a tracking device disposed at the distal end; and
a flexible circuit attached to the elongated body and extending from the proximal end to the distal end of the elongated body,
wherein
the flexible circuit is a first flexible circuit that has a sinusoidal periphery,
the flexible circuit has a base layer, a first trace and a second trace,
the first trace and the second trace are coupled to the tracking device,
the first trace and the second trace extend from the proximal end to the distal end,
a first portion of the first trace is on a first side of the base layer,
a second portion of the first trace is on a second side of the base layer
a first portion of the second trace is on the first side of the base layer, and
a second portion of the second trace is on the second side of the base layer.

US Pat. No. 9,168,080

BALLOON CATHETER

Medtronic CryoCath LP, T...

1. A medical device, comprising:
a catheter body defining a proximal portion, a distal portion, and a longitudinal axis;
an expandable element defining a proximal end and a distal end, the proximal end being coupled to the distal portion of the
catheter body;

a tip element including a distal portion that is affixed to the distal end of the expandable element and being at least partially
disposed within the expandable element, the tip element further including a shaft that extends proximally from the distal
portion of the tip element and that is slideably receivable within a portion of the catheter body;

a tensioning element coupled to the shaft and disposed within the expandable element, the tensioning element being engageable
with the distal end of the catheter body and biasing the expandable element toward a pre-determined longitudinal position
along the longitudinal axis; and

an electrode array defining a substantially closed loop affixed to and extending from the tip element.

US Pat. No. 9,066,726

MULTI-ELECTRODE APPOSITION JUDGMENT USING PRESSURE ELEMENTS

Medtronic Ardian Luxembou...

1. A system, comprising:
an intravascular catheter comprising an elongated shaft having a proximal portion and a distal portion configured for intravascular
insertion into a body lumen of a human patient;

a therapeutic assembly carried by the distal portion of the shaft, the therapeutic assembly including—
an energy delivery element configured to deliver energy to modulate nerves associated with sympathetic neural function;
a cylindrical capacitive sensor configured to measure contact force against a wall of the body lumen, the sensor being disposed
at or proximate to the energy delivery element, the cylindrical capacitive sensor having a plurality of regions that are circumferentially
separated by one or more non-conductive areas; and

a controller operably connected to the energy delivery element and the cylindrical capacitive sensor, the controller configured
to—

obtain a plurality of contact force measurements corresponding individually to the plurality of regions; and
determine an orientation of the energy delivery element relative to the wall of the body lumen based on at least one of the
plurality of contact force measurements.

US Pat. No. 9,056,162

INSERTION DEVICE

MEDTRONIC MINIMED, INC., ...

1. An insertion set, comprising:
a cannula housing of an infusion set including a cannula adapted to be inserted into the skin of a patient; and
an insertion device including:
a hub removably attachable to a base of the cannula housing of the infusion set, including a handle part and a guard part;
a needle attached to the hub; and
a collapse part attached to the handle part and having two opposing and parallel collapsible walls that are biased to improve
collapse of both walls when pressure is applied to the collapse part.

US Pat. No. 9,402,992

METHODS AND APPARATUS FOR MULTI-VESSEL RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. An apparatus for performing renal neuromodulation of a patient, the apparatus comprising:
an electric field generator configured for operation external to the patient;
a first element sized and shaped for intravascular placement within a first renal blood vessel of the patient, the first element
comprising a first electrode electrically coupled to the electric field generator; and

a second element sized and shaped for intravascular placement within a second renal blood vessel of the patient different
than the first renal blood vessel, the second element comprising a second electrode electrically coupled to the electric field
generator,

wherein the apparatus is configured for delivery of an electric field between the first electrode and the second electrode
to at least partially denervate a single kidney while the first element is located within the first renal blood vessel and
the second element is located within the second renal blood vessel.

US Pat. No. 9,333,077

DEVICES AND METHODS FOR PREPARING A TRANSCATHETER HEART VALVE SYSTEM

Medtronic Vascular Galway...

1. An assembly for loading and delivering a stented prosthetic heart valve, the assembly comprising:
a delivery device including:
a tube terminating at a distal end and defining a lumen,
a shaft disposed within the lumen and connect to a tip, the tip located distal the distal end; and
a valve loading device selectively connected to the delivery device, the valve loading device including:
a housing forming a chamber and terminating at opposing, first and second ends, wherein an opening to the chamber is defined
at each of the first and second ends,

a first sealing apparatus associated with the first end and configured to selectively sealingly engage the tip,
a second sealing apparatus associated with the second end and configured to selectively sealingly engage the tube,
a port open to the chamber;
wherein the assembly is configured to provide a flushing state in which a stented prosthetic heart valve is located within
the chamber and the valve loading device is assembled to the delivery device such that air bubbles entrained in a liquid delivered
to the chamber can be removed via the port.

US Pat. No. 9,326,816

NEUROMODULATION SYSTEMS HAVING NERVE MONITORING ASSEMBLIES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

Medtronic Ardian Luxembou...

12. A neuromodulation system for treating a human patient, comprising:
a generator configured to remain external to the patient;
a nerve monitoring assembly configured to detect electroneurogram (ENG) signals and distinguish the ENG signals from electromyogram
(EMG) signals; and

a neuromodulation catheter having an elongated shaft with a distal portion configured for intravascular delivery within the
patient and a proximal portion,

wherein the distal portion comprises an array of electrodes configured to detect nerve activity from within a blood vessel
of the patient, and

wherein the proximal portion comprises at least one connector operably coupling the electrodes to the generator and to the
nerve monitoring assembly.

US Pat. No. 9,326,708

AMBIENT TEMPERATURE SENSOR SYSTEMS AND METHODS

MEDTRONIC MINIMED, INC., ...

1. A monitoring system for measuring a physiological parameter, the system comprising:
a housing having electronics, the electronics including heat-generating electronics, a first sensor and a second sensor;
the first sensor configured to measure a sensed amount of a physiological parameter and to generate a first signal based on
the sensed amount of the physiological parameter measured by the first sensor; and

the second sensor electrically connected to the electronics in the housing and configured to measure a temperature and to
generate a second signal based on the temperature measured by the second sensor;

the heat-generating electronics comprising a processor configured to determine an overall amount of the physiological parameter
based on the first signal generated from the first sensor and the second signal generated from the second sensor;

the second sensor held by a support structure, the second sensor thermally insulated from the heat-generating electronics
and the first sensor and the second sensor are non-abutting; and

a thermal insulation material arranged to thermally insulate the second sensor from the heat-generating electronics and the
first sensor, while the second sensor remains electrically connected to the heat-generating electronics in the housing, wherein
the thermal insulation material is configured to thermally insulate the second sensor so that the temperature measured by
the second sensor is thermally insulated from heat emitted by the first sensor, and the thermal insulation material is arranged
between the first sensor and the second sensor through all direct line-of-sight convection paths from the first sensor to
the second sensor such that the temperature measured by the second sensor is isolated from the heat emitted by the first sensor
through all direct line-of-sight convection paths.

US Pat. No. 9,295,547

PROSTHESIS FOR TRANSCATHETER VALVE IMPLANTATION

Medtronic Vascular Galway...

1. A prosthesis comprising:
a stent structure; and
an annular frame having a circumferential border that extends in a radially outward direction from a central opening of the
annular frame, wherein a width of the circumferential border taken between an inner circumference of the annular frame and
an outer circumference of the annular frame is greater than an overall thickness of the annular frame taken between a first
or top surface and a second or bottom surface of the circumferential border, and wherein when the prosthesis is in an expanded
configuration the annular frame is laterally displaced to one side of the stent structure by a hinge segment that connects
the stent structure and the annular frame.

US Pat. No. 9,186,198

ULTRASOUND APPARATUSES FOR THERMALLY-INDUCED RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS

Medtronic Ardian Luxembou...

1. A method for catheter-based renal neuromodulation, the method comprising:
positioning a catheter having a therapeutic element within a renal blood vessel of a human patient and proximate to neural
fibers associated with renal function, wherein the therapeutic element comprises one or more ultrasound transducers positioned
along the catheter; and

thermally inhibiting neural activity along the neural fibers via ultrasound energy from the therapeutic element.

US Pat. No. 9,143,941

SECURE COMMUNICATION BY USER SELECTABLE COMMUNICATION RANGE

MEDTRONIC MINIMED, INC., ...

1. An infusion system to administer fluid, the infusion system comprising:
an infusion pump having a pump processor, a pump memory and a pump radio to enable bi-directional communication, the pump
radio further including an attenuator being configurable and the pump memory storing a plurality of security modes, each of
the plurality of security modes configuring the attenuator to receive signals of a predetermined strength, and

a controller having a controller processor, a controller memory, a controller radio to transmit and receive communication
from the pump radio, the controller further having a graphical user interface shown on a display, and controls to manipulate
the graphical user interface, the controller being paired with the infusion pump based on pairing data,

wherein a security check is performed when the infusion pump receives a suspect signal, the suspect signal not matching the
predetermined strength associated with a selected security mode.

US Pat. No. 9,107,994

SYSTEMS FOR FLUID RESERVOIR RETENTION

Medtronic MiniMed, Inc., ...

1. A fluid infusion device, comprising:
a fluid reservoir having a first portion and a second portion; and
a housing defining a receiving portion for removably receiving the fluid reservoir within the housing, the housing having
a first side adjacent to a second side, the first side including a first engagement system that cooperates with the first
portion and the second side including a second engagement system that cooperates with the second portion, the first engagement
system including a wedge and a pin, the pin fixedly coupled to the first side of the housing and the wedge movable along the
pin between a first position and a second position to bias the fluid reservoir relative to the housing in a direction substantially
opposite a direction of fluid flow out of the fluid reservoir.

US Pat. No. 9,307,936

POLAR PLOT TO REPRESENT GLUCOSE SENSOR PERFORMANCE

Medtronic Minimed, Inc., ...

1. A method comprising:
obtaining a plurality of blood glucose reference samples from a patient;
obtaining a plurality of glucose sensor measurements using a glucose sensor in contact with the patient;
computing a first rate of change in blood glucose concentration as observed from two or more of the plurality of blood glucose
reference samples;

computing a second rate of change in the blood glucose concentration as observed from two or more of the plurality of glucose
sensor measurements;

generating an angular coordinate and a radial coordinate of a polar plot,
wherein the angular coordinate is a function of the first rate of change and the second rate of change, and
wherein the radial coordinate is proportional to a magnitude of a blood glucose concentration of the patient as measured from
one or more of the plurality of blood glucose reference samples; and

generating signals to present a graphical representation of a value on the polar plot in a visual medium, wherein the value
corresponds to the angular coordinate and the radial coordinate, and

wherein the computing the first rate of change, the computing the second rate of change, the generating the angular coordinate
and the radial coordinate, and the generating signals to present the graphical representation are performed by one or more
processors.

US Pat. No. 9,265,455

METHODS AND SYSTEMS FOR OPTIMIZING SENSOR FUNCTION BY THE APPLICATION OF VOLTAGE

Medtronic MiniMed, Inc., ...

1. A method of initializing a sensor, comprising:
determining a disconnection time, wherein the disconnection time is the amount of time a sensor has been disconnected from
sensor electronics,

wherein the sensor is an analyte sensor,
selecting an initialization protocol based on the disconnection time, the initialization protocol selected from the group
consisting of:

a first initialization scheme comprising a first series of voltage pulses and a second initialization scheme comprising a
second series of voltage pulses,

wherein the first initialization scheme is selected if the disconnection time falls within a first time range and the second
initialization scheme is selected if the disconnection time falls within a second time range; and

applying the selected initialization protocol to the sensor.

US Pat. No. 9,267,875

ACCELERATED LIFE TESTING DEVICE AND METHOD

MEDTRONIC MINIMED, INC., ...

12. An accelerated life testing device for use on a test piece, the device comprising:
a test chamber for containing the test piece; and
an atmospheric controller operably connected to the test chamber, the atmospheric controller being operable to control temperature
and humidity within the test chamber;

wherein the atmospheric controller is operable to form an oxidation layer on the test piece by:
establishing a first atmosphere within the test chamber;
changing the first atmosphere to a second atmosphere to form a deposition layer on the test piece;
changing the second atmosphere to the first atmosphere to remove the deposition layer from the test piece; and
repeating the changing the first atmosphere to the second atmosphere and the changing the second atmosphere to the first atmosphere
to form the oxidation layer on the test piece.

US Pat. No. 9,108,040

METHODS AND APPARATUS FOR MULTI-VESSEL RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A treatment method for selectively affecting renal nerves proximate renal vasculature of a human patient, the method comprising:
positioning a first electrode within a first part of the renal vasculature, wherein the first part of the renal vasculature
is located within a renal artery or a first vessel branching from the renal artery;

positioning a second electrode within a second part of the renal vasculature, wherein the second part of the renal vasculature
is located within the renal artery or the first vessel branching from the renal artery or a second, different vessel branching
from the renal artery, and wherein the first and second parts of the renal vasculature are in different locations and are
both connected to the same kidney of the human patient;

delivering an electric field between the first and second electrodes, wherein at least a portion of the electric field defines
a treatment zone between the first and second electrodes; and

selectively modulating, via the electric field, a function of renal nerves passing through the treatment zone.

US Pat. No. 9,101,473

VENOUS VALVE REPAIR PROSTHESIS FOR TREATMENT OF CHRONIC VENOUS INSUFFICIENCY

Medtronic Vascular, Inc.,...

1. An endovascular prosthesis for restoring apposition to valve leaflets of a native valve comprising:
a wire forming a first helix from a distal end to a proximal end of the prosthesis and forming a second helix wound on top
of and concentric with the first helix from the proximal end to the distal end of the prosthesis to define a tubular body
having a blood flow lumen therethrough, wherein first and second free ends of the wire at the distal end of the prosthesis
define respective first and second valve apposition portions that are configured to inwardly extend toward each other from
opposing sides of the distal end of the prosthesis relative to a longitudinal axis of the prosthesis and to be spaced apart
from each other a distance for receiving the native valve there between when the prosthesis is in a deployed configuration,
and

wherein each of the first and second valve apposition portions is a closed loop formed by the respective first or second free
end of the wire and wherein the closed loops define substantially parallel valve contacting segments that are configured to
contact the native valve when the prosthesis is in the deployed configuration.

US Pat. No. 9,056,165

INTELLIGENT THERAPY RECOMMENDATION ALGORITHM AND METHOD OF USING THE SAME

Medtronic MiniMed, Inc., ...

1. A method of automatically making a therapy recommendation to adjust a stored insulin pump parameter, the method comprising
the steps of:
obtaining a blood glucose value at the end of a time interval;
determining if an intervening event occurred during the time interval before the blood glucose value was obtained, wherein
the intervening event includes at least one of a meal, a correction bolus, and an error code that changes the blood glucose
value unrelated to the stored pump parameter and thereby interferes with recommending a change to the stored pump parameter;

recommending no change to the stored pump parameter based on the blood glucose value if the intervening event occurred during
the time interval before the blood glucose value was obtained;

updating a recommended change to the stored pump parameter based on a previous recommended change to the stored pump parameter
and the difference between the blood glucose value and a target blood glucose level if no intervening event occurred during
the time interval;

comparing an absolute value of the updated recommended change to a predefined threshold value of the stored pump parameter,
wherein the predefined threshold value is 0.05 or 0.1 U/h when the stored pump parameter is a basal rate, the predefined threshold
value is 5 grams carbohydrates per unit of insulin when the stored pump parameter is a carbohydrate-to-insulin ratio (CR),
and the predefined threshold value is 5 mg/dl for a Unit of insulin when the stored pump parameter is an insulin sensitivity
factor (ISF);

making the therapy recommendation if the updated recommended change exceeds the threshold and the therapy recommendation is
within safety parameters; and

displaying the therapy recommendation to adjust the stored pump parameter.

US Pat. No. 9,393,140

RECONFIGURABLE STENT-GRAFT DELIVERY SYSTEM AND METHOD OF USE

Medtronic Vascular, Inc.,...

1. A delivery system for delivering and deploying a main stent-graft prosthesis and for introducing one or more additional
delivery systems thereafter, the delivery system comprising:
a tubular sheath component defining a lumen from a proximal end to distal end thereof;
an elongate tubular member that defines at least a portion of a main guidewire lumen and that extends within the sheath component
lumen from a proximal end to a distal end of the delivery system;

a removable middle member component having a middle member shaft that extends within and divides at least a proximal portion
of the sheath component lumen into a plurality of working lumens when the delivery system is in a multi-lumen delivery catheter
configuration for delivering and deploying the main stent-graft prosthesis, and having a middle member handle fixedly attached
to a proximal end of the middle member shaft, wherein at least a portion of the elongate tubular member extends through one
of the plurality of working lumens of the middle member shaft when the delivery system is in the multi-lumen delivery catheter
configuration; and

a handle component operably attached to the proximal end of the sheath component for proximally retracting the sheath component
relative to the elongate tubular member, wherein the handle component includes a proximal port of the main guidewire lumen
and a middle member port at which the middle member handle is removably coupled to the delivery system for permitting the
middle member component to be removed from the lumen of the sheath component.

US Pat. No. 9,330,237

PATTERN RECOGNITION AND FILTERING IN A THERAPY MANAGEMENT SYSTEM

Medtronic MiniMed, Inc., ...

1. A method of diabetes analysis, comprising:
receiving, using a processor and a glucose sensor, a plurality of glucose level readings over a plurality of days for a user,
each of the plurality of glucose level readings having multiple glucose level measurements for one of the plurality of days;

determining, using the processor, a common event occurrence in at least two of the glucose level readings;
analyzing, using the processor, the at least two glucose level readings from the common event occurrence onwards in time for
a time period;

identifying, using the processor, a glucose level pattern formed by the at least two glucose level readings having a similar
shape;

analyzing, using the processor, an anomalous glucose level reading not conforming to the glucose level pattern to determine
whether the anomalous glucose level reading has the similar shape;

adjusting, using the processor, the anomalous glucose level reading to adapt to the glucose level pattern to form an adapted
glucose level pattern if the anomalous glucose level reading has the similar shape;

filtering out, using the processor, the anomalous glucose level reading if the anomalous glucose level reading does not have
the similar shape;

calculating, using the processor, an insulin dosage for the time period beginning at the common event occurrence based on
the adapted glucose level pattern; and

initiating an action, wherein the action includes at least one of recommending the calculated dosage and automatically delivering
the calculated insulin dosage,

wherein the method is implemented on a portable medical system.

US Pat. No. 9,254,168

ELECTRO-THERMOTHERAPY OF TISSUE USING PENETRATING MICROELECTRODE ARRAY

MEDTRONIC ADVANCED ENERGY...

1. Apparatus for electrosurgery of tissue, the apparatus comprising:
an array of two or more protruding treatment electrodes adapted to be inserted into tissue and adapted to be connected to
an electrical source,

the array of two or more protruding treatment electrodes is configured to be energized by an electrosurgical waveform from
the electrical source such that plasma-mediated interactions at the array of two or more protruding treatment electrodes ablate
part of the tissue;

one or more return electrodes; and
a compressible pad configured to be disposed between the one or more return electrodes and the tissue during use, the array
of two or more protruding treatment electrodes is adapted to project through the compressible pad when inserted into tissue.

US Pat. No. 9,242,086

SYSTEM FOR MEDICAL STIMULATION COMPRISING A PROBE

MEDTRONIC BAKKEN RESEARCH...

1. A system for medical stimulation, the system comprising:
an implantable probe bifurcated into a primary branch and a secondary branch at a bifurcation, the probe including at least
one electrode proximate a distal end of the probe for delivering electrical stimulation to brain tissue and an electrical
wire for electrically connecting the at least one electrode to a device for generating the electrical stimulation,

wherein the primary branch is configured for temporarily mechanically co-operating with a guide wire configured for guiding
the probe into said brain tissue, the guide wire configured to fit into the probe and temporarily provide mechanical stiffness
to the probe,

wherein the primary branch is provided at its proximal end with an aperture for receiving the guide wire in a canal configured
for accommodating the guide wire,

wherein the secondary branch is configured for electrically connecting said at least one electrode to the device for generating
the electrical stimulation, and

wherein the electrical wire extends through the secondary branch and spirals around the canal for electrically connecting
the at least one electrode to the device.

US Pat. No. 9,220,556

BALLOON DESIGN TO ENHANCE COOLING UNIFORMITY

Medtronic CryoCath LP, T...

1. A medical device comprising:
a cooling chamber including an interior wall and an exterior wall;
a coolant delivery element disposed within the cooling chamber; and
a coolant distribution element disposed within the cooling chamber that guides coolant delivered from the coolant delivery
element toward the interior wall of the cooling chamber, the coolant distribution element being disposed within the cooling
chamber so as to divide the cooling chamber into a distal first portion and a proximal second portion.

US Pat. No. 9,186,213

METHODS FOR RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for treatment of a human patient diagnosed with hypertension, the method comprising:
extravascularly positioning a device having an energy delivery element in a vicinity of a renal nerve of the patient; and
delivering an energy field reduces neural signaling to or from the kidney and via the energy delivery element to modulate
a function of the renal nerve,

wherein delivering the energy field results in a therapeutically beneficial reduction in blood pressure of the patient.

US Pat. No. 9,107,999

METHODS AND APPARATUSES FOR DETECTING OCCLUSIONS IN AN AMBULATORY INFUSION PUMP

MEDTRONIC MINIMED, INC., ...

1. A method of detecting an occlusion in an infusion pump having a reservoir and a drive mechanism that includes a motor and
one or more drive train components for infusing fluid from the reservoir into a body of a user through delivery of one or
more separate pulses of infusion fluid, wherein consecutive pulses of infusion fluid are separated by a period of time during
which no fluid is infused into the user's body, the method comprising:
during delivery of a single one of said one or more separate pulses of infusion fluid, periodically measuring the value of
a parameter associated with the motor or one of the drive train components to obtain a series of measurements;

determining a peak value of the series of measurements;
selecting a second value within the series of measurements later in time than the peak value;
calculating a difference between the peak value and the second value; and
declaring an occlusion has occurred if the difference exceeds a threshold value.

US Pat. No. 9,345,900

METHODS AND SYSTEMS FOR THERMALLY-INDUCED RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for thermally inducing neuromodulation in a human patient, the method comprising:
positioning an electrode within a renal blood vessel of the human patient;
determining a tissue site suitable for treatment within the renal blood vessel;
delivering energy via the electrode to a renal nerve of the patient proximate to or within the tissue site;
increasing the energy delivered to the electrode at a generally constant rate to a predetermined first power level over a
first period of time;

maintaining the energy delivered to the electrode at the first power level for a second period of time after reaching the
first power level;

measuring a temperature value related to a wall of the renal blood vessel or the electrode; and
if the temperature value is less than a preset temperature threshold and a measured impedance value s less than a predetermined
impedance threshold, then increasing the energy delivered to the electrode until a target maximum power level is reached.

US Pat. No. 9,320,871

SYSTEMS AND METHODS FOR VARIABLE INJECTION FLOW

Medtronic CryoCath LP, T...

1. A method of controlling fluid delivery in a medical device, comprising:
movably positioning a fluid delivery conduit within a delivery manifold in the medical device, the fluid delivery conduit
defining a first plurality of openings and the delivery manifold defining a second plurality of openings, the medical device
defining a distal tip and including a first thermally transmissive region proximate the delivery manifold and a second thermally
transmissive region at the distal tip;

introducing a fluid into the fluid delivery conduit;
moving the fluid delivery conduit to a first position where the first plurality of openings is substantially aligned with
the second plurality of openings to direct fluid through the first and second plurality of openings and toward the first thermally
transmissive region to create an elongated treatment pattern; and

moving the fluid delivery conduit to a second position where the second plurality of openings are substantially obstructed
by the fluid delivery conduit, and at least one of the plurality of first openings is positioned outside the manifold such
that fluid is directed through the at least one of the plurality of first openings and toward the second thermally transmissive
region to create a focal treatment pattern.

US Pat. No. 9,320,471

ALGORITHM SENSOR AUGMENTED BOLUS ESTIMATOR FOR SEMI-CLOSED LOOP INFUSION SYSTEM

Medtronic MiniMed, Inc., ...

1. An infusion system for infusing a fluid into the body of a patient, the system comprising:
a sensor system that includes a sensor for monitoring blood glucose concentration of a patient, and produces at least one
sensor signal, which is representative of the blood glucose concentration of the patient, and wherein the at least one sensor
signal is used to generate at least one sensor signal input;

a controller, wherein the controller uses the at least one sensor signal input and a derivative predicted algorithm to determine
at least one sensor-derived blood glucose trend, and wherein the at least one sensor-derived blood glucose trend is used to
determine blood glucose levels at a predetermined time in the future, wherein the derivative predicted algorithm calculates
a first derivative of a sensor current sample from the at least one sensor signal input at time period n, and then calculates
a first derivative of a sensor glucose value from the at least one sensor signal input using the first derivative of the sensor
current sample to determine future blood glucose levels, wherein the first derivative of the sensor current sample is calculated
from a slope of the sensor current sample versus time using a Savitzky-Golay finite impulse response filter; and

a delivery system that infuses a fluid into the patient, wherein operation of the delivery system is affected by commands
from the controller and the patient,

wherein the controller suspends fluid delivery if the at least one sensor-derived trend yields at least one blood glucose
level reading that is below a predefined low shutoff threshold.

US Pat. No. 9,314,588

SYSTEMS AND METHODS FOR VARIABLE INJECTION FLOW

Medtronic CryoCath LP, T...

1. A medical device, comprising:
a catheter body defining a distal portion having a thermally transmissive region, the thermally transmissive region defining
a chamber;

a fluid delivery conduit located entirely within the catheter body and defining an outlet in fluid communication with the
chamber of the thermally transmissive region;

a solid elongate member slidably disposed within at least a portion of the fluid delivery conduit, advancing and retracting
the solid elongate member selectively obstructing and un-obstructing a portion of the fluid delivery conduit to modulate fluid
flow through the outlet.

US Pat. No. 9,387,074

MEDICAL DEVICE DELIVERY SYSTEMS AND METHODS

Medtronic Vascular Galway...

1. A delivery system for deploying a medical device, comprising:
a first attachment member configured to selectively couple to and radially constrain a first end portion of the medical device,
wherein the first attachment member includes an outer surface defining a plurality of slots leading to a cavity, wherein each
of the plurality of slots is configured to receive a respective one of a plurality of coupling members of the first end portion
of the medical device, wherein the first attachment member is configured to rotate between

a first position wherein the plurality of coupling members are configured to be disposed in the cavity and the plurality of
slots are radially misaligned with the coupling members such that the outer surface radially constrains the coupling members,
and

a second position wherein each of the plurality of slots is radially aligned with one of the plurality of coupling members
such that each of the coupling members may expand radially outward from the cavity through a respective one of the plurality
of slots; and

a second attachment member configured to selectively couple to and radially constrain a second end portion of the medical
device,

wherein the first attachment member is configured to move relative to the second attachment member such that the first attachment
member applies a first tensile force to the first end portion of a medical device in a first direction and the second attachment
member applies a second tensile force to the second end portion of a medical device in a second direction substantially opposite
from the first direction.

US Pat. No. 9,272,147

METHOD AND APPARATUS TO DELIVER MECHANICALLY FUSED PACING THERAPY

Medtronic, Inc., Minneap...

1. A medical device system for delivering mechanically fused left ventricular cardiac stimulation, said system comprising:
an implantable medical device (IMD);
a plurality of electrical medical leads coupled to the IMD and adapted to deliver left ventricular stimulation to a patient
upon expiration of an AV interval; and

at least one sensor capable of monitoring left ventricular motion and providing a left ventricular motion signal to the IMD,
the IMD configured to determine a mechanical response interval measured from delivery of the left heart ventricular stimulation
based on the left ventricular motion signal, the IMD configured to adjust the AV interval after determining that the mechanical
response interval differs from a predetermined desired mechanical response interval in order to deliver mechanically-fused
left ventricular cardiac stimulation.

US Pat. No. 9,089,641

AUTOMATED FILLING SYSTEMS AND METHODS

MEDTRONIC MINIMED, INC., ...

1. A system for automated pressure equalization, the system comprising:
a transfer guard, the transfer guard comprising:
a first needle having a fluid path for transferring fluidic media from an interior volume of a vial to an interior volume
of a reservoir;

a second needle having a fluid path for communicating between atmosphere and the interior volume of the vial; and
a bias member connected between an end of the reservoir and a plunger head positioned in the reservoir, the bias member for
providing a force behind the plunger head as the plunger head is moved within the reservoir to transfer fluidic media from
the interior volume of the vial to the interior volume of the reservoir;

the bias member and the transfer guard configured to equalize pressure relative to atmosphere in the interior volume of the
vial in a case where the second needle communicates between atmosphere and the interior volume of the vial and the plunger
head is moved within the reservoir to transfer fluidic media from the interior volume of the vial to the interior volume of
the reservoir.

US Pat. No. 9,480,846

SYSTEMS AND METHODS FOR PATIENT CONTROL OF STIMULATION SYSTEMS

Medtronic Urinary Solutio...

1. A portable controller for recharging and communicating with an implanted medical device, the controller comprising:
a shell;
a recharging module at least partially disposed in the shell, the recharging module configured to recharge a power supply
of the implanted medical device; and

a telemetry module at least partially disposed in the shell, the telemetry module configured to communicate via non-inductive
wireless telemetry with the implanted medical device while the recharging module recharges the power supply of the implanted
medical device, wherein the recharging module comprises a charging coil configured to generate a radio frequency magnetic
field that transcutaneously recharges the power supply of the implanted medical device, and wherein the charging coil is at
least partially disposed outside of the shell.

US Pat. No. 9,242,109

APPARATUS AND METHODS FACILITATING POWER REGULATION FOR AN IMPLANTABLE DEVICE

Medtronic, Inc., Minneap...

8. A power regulation system for an implantable medical device, comprising:
a processor operatively coupled to the implantable medical device;
a non-transitory computer readable medium that stores computer executable components, wherein the non-transitory computer
readable medium comprises flash memory;

a central processing unit (CPU) power regulator configured to provide a first current level to the processor;
an analog power regulator configured to provide a second current level to the processor, wherein the second current level
is lower that the first current level;

a flash power regulator configured to provide a third current level to the flash memory; and
a regulator switch configured to enable or disable current draw from the CPU power regulator and the analog power regulator
as a function of a power state of the processor, wherein the third current level is higher than the first current level, and
wherein the regulator switch is configured to enable current draw from the flash power regulator and disable current draw
from the analog power regulator and CPU power regulator in response to programming or erasing of the flash memory.

US Pat. No. 9,131,978

METHODS FOR BILATERAL RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for catheter-based renal neuromodulation of a human patient with a diagnosed condition comprising at least one
of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure, the method
comprising:
intravascularly positioning a first catheter comprising a single first electrode within a first renal blood vessel of a human
patient and proximate to neural fibers that innervate a first kidney of the patient; and

inhibiting neural communication along the neural fibers innervating the first kidney via radio frequency (RF) energy from
the first electrode;

intravascularly positioning a second catheter comprising a single second electrode within a second renal blood vessel of the
patient and proximate to neural fibers that innervate a second kidney of the patient; and

inhibiting neural communication along the neural fibers innervating the second kidney via RF energy from the second electrode,
wherein inhibiting neural communication along the neural fibers innervating the first and second kidney significantly improves
a measurable physiological parameter corresponding to the diagnosed condition of the patient.

US Pat. No. 9,066,720

DEVICES, SYSTEMS AND METHODS FOR EVALUATION AND FEEDBACK OF NEUROMODULATION TREATMENT

Medtronic Ardian Luxembou...

1. An energy source for renal neuromodulation configured for connecting to a catheter having a distal portion comprising an
energy delivery element configured for placement at a treatment site within a renal blood vessel, the energy source adapted
to be coupled to the energy delivery element and configured to deliver energy via the energy delivery element to target neural
fibers proximate to a wall of the renal blood vessel,
wherein the energy source comprises a component configured to—
increase energy delivery to a predetermined first power level over a first period of time;
maintain energy delivery at the first power level for a second period of time; and
increase energy delivery to a second predetermined power level if the temperature value is less than a preset threshold temperature
following the second period of time; and

wherein the energy source further comprises a component configured to—
obtain a set of treatment data corresponding to a completed treatment performed using the catheter, the energy source, and
the energy delivery element;

evaluate the set of treatment data in view of one or more criteria to determine if a valuation of the completed treatment
is likely within a pre-determined range; and

provide an indication as to whether the valuation of the completed treatment is likely within the pre-determined range.

US Pat. No. 9,283,382

INTERVENTIONAL MEDICAL SYSTEMS, TOOLS, AND ASSOCIATED METHODS

Medtronic, Inc., Minneap...

1. An interventional medical system comprising an implantable device and a delivery tool facilitating deployment of the implantable
device, the device including an attachment structure and a fixation member, the fixation member being configured to engage
tissue at an implant site and thereby fix the device at the implant site; and the tool comprising an outer tube and a core,
the outer tube comprising a distal-most portion sized to receive the device therein, the core extending within the outer tube,
and the core comprising:
a distal member located within the distal-most portion of the outer tube, the distal member being configured to form a snap
fit with the attachment structure of the device, the snap fit temporarily attaching the device to the tool; and

wherein the snap fit of the distal member disengages to release the attached device, only when a tug force, applied to the
core of the tool, is greater than or equal to a predetermined force, the predetermined force corresponding to a minimum adequate
fixation force of the engaged fixation member fixing the device at the implant site.

US Pat. No. 9,138,292

MULTI-ELECTRODE CATHETER ASSEMBLIES FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS

Medtronic Ardian Luxembou...

1. A renal neuromodulation system for treatment of a human patient, the system comprising:
an energy source including a radio-frequency identification (RFID) evaluation module;
a catheter, including—
a handle assembly configured to operably couple to the energy source;
a radio-frequency identification (RFID) tag configured to communicate with the RFID evaluation module;
an elongate tubular shaft having a proximal portion coupled to the handle assembly and a distal portion;
a therapeutic assembly disposed at the distal portion of the elongated shaft and adapted to be located at a target location
within a renal artery of a human patient, the therapeutic assembly including a support structure comprising—

a control member comprising a pre-formed helical shape; and
a plurality of energy delivery elements carried by the support structure,
wherein the elongated tubular shaft and the therapeutic assembly together define therethrough a guide wire lumen configured
to slidably receive a medical guide wire, and

wherein axial movement of the guide wire relative to the therapeutic assembly transforms the support structure between (a)
a low-profile delivery configuration and (b) a deployed configuration tending to assume the pre-formed helical shape of the
control member; and

a cable configured to operably couple the energy source and the catheter, wherein the RFID tag is positioned along the cable.

US Pat. No. 9,056,171

ARTERIOVENOUS SHUNT HAVING ECCENTRIC ANCHOR STENT

Medtronic Vascular, Inc.,...

1. An arteriovenous shunt assembly comprising:
a tubular shunt defining a fluid passageway between open first and second ends thereof, the tubular shunt having a first end
segment for placement in a first vessel, the first shunt end segment having an outer diameter smaller than a lumen diameter
of the first vessel;

a first self-expanding anchor stent having an expanded diameter greater than an expanded diameter of the tubular shunt, the
first anchor stent being eccentrically coupled about the first shunt end segment such that in an expanded configuration a
longitudinal axis of the first shunt end segment is parallel to and radially offset in a first direction from a longitudinal
axis of the first anchor stent;

a second shunt end segment for placement in a second vessel, the second shunt end segment having an outer diameter smaller
than a lumen diameter of the second vessel; and

a second self-expanding anchor stent having an expanded diameter greater than an expanded diameter of the tubular shunt, the
second anchor stent being eccentrically coupled about the second shunt end segment such that in an expanded configuration
a longitudinal axis of the second shunt end segment is parallel to and radially offset in a second direction from a longitudinal
axis of the second anchor stent, wherein the second offset direction is substantially opposite the first offset direction.

US Pat. No. 9,327,122

METHODS FOR CATHETER-BASED RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for catheter-based renal neuromodulation, the method comprising:
intravascularly positioning an electrode of a catheter within renal vasculature of a human patient and proximate to neural
fibers that innervate a kidney of the patient; and

delivering an electric field between the electrode and a ground pad coupled to an exterior of the patient, thereby thermally
inhibiting neural communication along the neural fibers,

wherein delivering the electric field and thermally inhibiting neural communication along the neural fibers results in a therapeutically
beneficial reduction in blood pressure of the patient.

US Pat. No. 9,265,881

THERAPEUTIC AGENT INJECTION DEVICE

MEDTRONIC MINIMED, INC., ...

1. An injection device for delivering a therapeutic agent to a patient, the injection device comprising:
a body having a patient face and a port face opposite the patient face, the port face having an introducer port including
an introducer channel and an injection port including an injection channel, the introducer channel being in fluid communication
with the injection channel, the injection channel defining an injection axis;

a delivery tube for subcutaneous delivery of the therapeutic agent to the patient, the delivery tube projecting from and being
generally perpendicular to the patient face, the delivery tube defining an introducer axis and being in fluid communication
with the injection port;

a patch attached to the patient face and operable to adhesively attach to the patient; and
an injection adapter assembly removably connected to the injection port, the injection adapter assembly receiving a needleless
pen injector;

wherein the body has a first body portion including the port face and a second body portion including the patient face, the
first body portion and the second body portion being rotatably connected with a flange, the first body portion and the second
body portion being independently rotatable about the introducer axis.

US Pat. No. 9,265,558

METHODS FOR BILATERAL RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for catheter-based renal neuromodulation of a human patient, the method comprising:
positioning a first catheter within a first renal blood vessel of the patient and proximate to neural fibers innervating a
first kidney of the patient;

delivering a first neuromodulatory agent via the first catheter to the neural fibers innervating the first kidney, wherein
the first neuromodulatory agent inhibits neural traffic along the neural fibers innervating the first kidney;

positioning a second catheter within a second renal blood vessel of the patient and proximate to neural fibers innervating
a second kidney of the patient; and

delivering a second neuromodulatory agent via the second catheter to the neural fibers innervating the second kidney, wherein
the second neuromodulatory agent inhibits neural traffic along the neural fibers innervating the second kidney.

US Pat. No. 9,144,685

USING FOCAL MYOCARDIAL STIMULATION TO DISTINGUISH SUPRAVENTRICULAR TACHYCARDIA FROM VENTRICULAR TACHYCARDIA

Medtronic, Inc., Minneap...

13. A medical device for discriminating a cardiac event, comprising:
sensing circuitry for sensing atrial and ventricular depolarizations having associated refractory periods thereafter;
pacing circuitry for delivering stimulus pulses to atrial tissue; and
a processor configured to:
detect a fast ventricular rate in response to the sensed ventricular depolarizations,
in response to detecting the fast ventricular rate, set an atrial pacing time interval that expires in an excitation window
that extends from an end of the atrial refractory period to an end of the ventricular refractory period,

upon expiration of the atrial pacing interval deliver a stimulus pulse to atrial tissue within the associated refractory period
of the ventricle but outside of the associated refractory period of the stimulated atrial tissue, determine a ventricular
response to the atrial tissue stimulus pulse; and

discriminate a cardiac event associated with the fast ventricular rate based on the ventricular response to the atrial tissue
stimulus pulse.

US Pat. No. 9,271,856

DELIVERY CATHETER WITH DISTAL MOVING CAPSULE FOR TRANSAPICAL PROSTHETIC HEART VALVE DELIVERY

Medtronic Vascular Galway...

1. A prosthesis delivery system comprising:
a handle assembly including a rotatable control knob;
an intermediate shaft extending from the handle assembly and having an interior lumen, the intermediate shaft having a prosthesis
retaining element connected to a distal end thereof;

an introducer shaft having an interior lumen and a tapered introducer tip attached at a distal end thereof, wherein a proximal
end of the introducer shaft is connected to a hub secured to the intermediate shaft and configured to slide in a proximal
and distal direction along the intermediate shaft;

an inner shaft extending from the handle assembly and configured to be moved in a proximal direction by rotating the control
knob in a first direction and to be advanced in a distal direction by rotating the control knob in a second direction that
is opposite of the first direction; and

a capsule including a proximal end, a distal end and a capsule tip, wherein the distal end of the capsule is connected to
a distal end of the inner shaft, the proximal end of the capsule is configured to have an interference fit with the prosthesis
retaining element of the intermediate shaft in a deployment stage and to receive the tapered introducer tip in each of a delivery
stage and a retraction stage, and the capsule is configured to contain a prosthesis device, and

wherein when the control knob is rotated in the second direction the inner shaft and the capsule advance together in the distal
direction relative to the prosthesis device until the proximal end of the capsule contacts the prosthesis retaining element
and thereafter further distal advancement is prevented.

US Pat. No. 9,272,140

METHOD, SYSTEM AND DEVICE FOR TREATING DISORDERS OF THE PELVIC FLOOR BY ELECTRICAL STIMULATION OF THE SACRAL AND/OR PUDENDAL NERVES

MEDTRONIC, INC., Minneap...

1. A method of treating at least one pelvic floor disorder, the at least one disorder being selected from a group consisting
of prostatitis, prostatalgia and prostatodynia, the method comprising:
delivering electrical stimulation from a medical device implanted within a patient diagnosed with the pelvic floor disorder
to a pudendal nerve or branches or portions thereof of the patient via at least one electrode of a lead implanted within the
patient proximate to the pudendal nerve or branches or portions thereof; and

configuring the electrical stimulation to provide at least partial relief from the pelvic floor disorder.

US Pat. No. 9,231,617

MEDICAL DEVICE WITH MEMBRANE KEYPAD SEALING ELEMENT, AND RELATED MANUFACTURING METHOD

Medtronic MiniMed, Inc., ...

1. A medical device comprising:
a housing having a front face, a keypad mounting cavity on the front face, and a sealing rim on the front face, the sealing
rim surrounding the keypad mounting cavity;

a membrane keypad assembly coupled to the housing and positioned inside the keypad mounting cavity, the membrane keypad assembly
comprising a plurality of actuation components integrated therein;

a sealing element comprising a perimeter area, the sealing element overlying the membrane keypad assembly such that the perimeter
area extends beyond the membrane keypad assembly, and the perimeter area coupled to the sealing rim to form a fluid resistant
seal with the housing; and

a graphic keypad overlay removably adhered to the sealing element to be replaceable with a different graphic keypad overlay,
the graphic keypad overlay comprising graphical representations corresponding to the actuation components.

US Pat. No. 9,108,068

CAPACITOR ELECTROLYTE

Medtronic, Inc., Minneap...

1. An implantable cardioverter-defibrillator comprising an electrolytic capacitor comprising:
an anode comprising tantalum;
a cathode;
a separator coupled to the anode and the cathode;
an electrolyte comprising:
water;
tetraethylene glycol dimethyl ether; and
one or more ingredients selected from acetic acid, ammonium acetate, and phosphoric acid; and
an oxide layer on the anode that is formed at a formation voltage.

US Pat. No. 9,439,708

NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS

Medtronic Ardian Luxembou...

1. A cryotherapeutic device, comprising:
an elongated shaft having a distal portion and a proximal portion;
a cryogenic cooling assembly at the distal portion of the shaft;
a supply lumen extending along a length of the shaft, the supply lumen being configured to carry refrigerant distally toward
the cooling assembly;

a pre-cooling assembly operably connected to the supply lumen, the pre-cooling assembly including—
a first tubular region configured to contain refrigerant,
a second tubular region downstream from the first tubular region, and
a flow separator disposed between the first and second tubular regions, the flow separator being configured to direct a first
flow of refrigerant from the first tubular region into the supply lumen and to direct a second flow of refrigerant from the
first tubular region into the second tubular region; and

a supply conduit defining a portion of the supply lumen extending through the second tubular region,
wherein, in operation, the second flow of refrigerant expands within the second tubular region in direct contact with the
supply conduit, thereby cooling the first flow of refrigerant while the first flow of refrigerant moves through the portion
of the supply lumen extending through the second tubular region.

US Pat. No. 9,327,123

ENDOVASCULAR NERVE MONITORING DEVICES AND ASSOCIATED SYSTEMS AND METHODS

Medtronic Ardian Luxembou...

1. A method of monitoring renal nerve activity, the method comprising:
deploying a nerve monitoring assembly in a renal artery of a human patient, wherein the nerve monitoring assembly comprises
a first electrode array at a distal portion of a shaft and a second electrode array spaced laterally apart from the first
electrode array, wherein deploying the nerve monitoring assembly in the renal artery further comprises inflating a first balloon
within the renal artery, wherein the inflated first balloon contacts an inner wall of the renal artery, and wherein the first
and second electrode arrays are on an outer surface of the first balloon;

delivering a neuromodulation assembly to a target site within the renal artery between the first and second electrode arrays,
wherein delivering the neuromodulation assembly to the target site within the renal artery between the first and second electrode
arrays further comprises inflating a second balloon within the first balloon, wherein the second balloon is configured to
contact the first balloon to define a neuromodulation region;

stimulating renal nerves with the first electrode array, wherein the stimulation energy is at a magnitude which induces renal
nerve activity;

recording, with the second electrode array, renal nerve activity resulting from the stimulating act; and
applying therapeutically-effective neuromodulation energy to the target site with the neuromodulation assembly, wherein the
neuromodulation energy is at a level which inhibits, reduces, or blocks renal nerves, and wherein applying therapeutically-effective
neuromodulation energy to the target site with the neuromodulation assembly further comprises applying cryogenic cooling to
the renal artery proximate the neuromodulation region.

US Pat. No. 9,265,884

ON-BODY INJECTOR AND METHOD OF USE

MEDTRONIC MINIMED, INC., ...

1. An on-body injector for use with a patient with an injection device having an injection port in fluid communication with
a delivery tube, the injection port lying on an injection axis, the on-body injector comprising:
a bolus reservoir;
a bolus injection needle in fluid communication with the bolus reservoir, the bolus injection needle having a bolus injection
needle tip aligned with the injection port, the bolus injection needle being slideably biased away from the injection port
to define a gap between the bolus injection needle tip and the injection port; and

a button operably connected to the bolus injection needle to slide the bolus injection needle along the injection axis;
wherein the button is operable to advance the bolus injection needle tip to close the gap and advance the bolus injection
needle tip into the injection port to form an injection flow path from the bolus reservoir, through the bolus injection needle,
through the delivery tube, and into the patient;

wherein the button is further operable to advance a plunger through the bolus reservoir to deliver a predetermined bolus volume
to the patient through the injection flow path; and

a pressurized reservoir in fluid communication with the bolus reservoir.

US Pat. No. 9,272,148

COMBINATION OF FEEDBACK ON MECHANICAL AND ELECTRICAL RESYNCHRONIZATION TO SELECT THERAPY PARAMETERS

Medtronic, Inc., Minneap...

1. A method for selecting a pacing therapy site, comprising:
sensing baseline mechanical heart activity and baseline electrical heart activity;
storing the baseline mechanical heart activity and baseline electrical heart activity;
sensing mechanical heart activity and electrical heart activity during pacing at each of a plurality of pacing sites along
a heart chamber;

storing the mechanical heart activity and electrical heart activity;
determining a change from the baseline mechanical heart activity to the sensed mechanical activity for each of the plurality
of pacing sites along the heart chamber;

determining a change from the baseline electrical activity to the sensed electrical heart activity for each of the plurality
of pacing sites along the heart chamber;

sorting the plurality of pacing sites in a first order based upon the changes in mechanical heart activity;
sorting the plurality of pacing sites in a second order based upon the changes in electrical heart activity; and
selecting a pacing site from the plurality of pacing sites as a common pacing site between the first order and the second
order.

US Pat. No. 9,192,766

RENAL NEUROMODULATION METHODS AND DEVICES FOR TREATMENT OF POLYCYSTIC KIDNEY DISEASE

Medtronic Ardian Luxembou...

1. A method of treating a human patient diagnosed with polycystic kidney disease, the method comprising:
intravascularly positioning a neuromodulation assembly within a renal blood vessel of the patient and adjacent to a renal
nerve of the patient; and

at least partially inhibiting sympathetic neural activity in the renal nerve of the patient via the neuromodulation assembly,
wherein inhibiting sympathetic neural activity reduces an average size of one or more kidney cysts in the patient diagnosed
with polycystic kidney disease.

US Pat. No. 9,345,538

SYSTEMS AND METHODS FOR NEUROMODULATION FOR TREATMENT OF DISORDERS ASSOCIATED WITH NERVE CONDUCTION

Medtronic Ardian Luxembou...

1. A method for treating a disorder associated with nerve conduction in a human patient, the method comprising:
advancing a catheter comprising one or more electrodes through an artery of the patient, wherein the one or more electrodes
comprise a treatment electrode and a monitoring electrode;

delivering a first energy from the treatment electrode to a treatment area of nerve tissue of the patient, wherein the nerve
tissue comprises nerves located adjacent to the artery of the patient, and wherein the first energy irreversibly disrupts
the nerve tissue; and

after delivering the first energy, using the monitoring electrode to monitor the treatment area and thereby determine a degree
of treatment achieved therein.

US Pat. No. 9,192,707

ELECTROLYTE AND PH MONITORING FOR FLUID REMOVAL PROCESSES

Medtronic, Inc., Minneap...

1. A system comprising:
a blood fluid removal device comprising:
(i) an inlet for receiving blood from a patient,
(ii) an outlet for returning blood from the patient,
(iii) a medium for removing fluid and contaminants from the blood, the medium being positioned between the inlet and the outlet,
and

(iv) a fluid source for carrying dialysate to the medium;
a concentrate source for housing a concentrate solution comprising concentrated electrolyte or pH buffer;
a concentrate flow control element for controlling the rate that the concentrate solution enters the fluid source;
a first sensor configured to monitor an indicator of blood electrolyte concentration or blood pH in the blood before the blood
enters the medium,

a second sensor configured to monitor an indicator of blood electrolyte concentration or blood pH in the blood after the blood
exits the medium and before a replacement fluid is added to the blood; and

control electronics in operable communication with the first sensor and the concentrate flow control element,
wherein the control electronics are configured, via the concentrate flow control element, to adjust the rate at which the
concentrate solution enters the fluid source based on the rate of change of blood pH or blood electrolyte concentration based
on data obtained from the first sensor and the second sensor.

US Pat. No. 9,486,270

METHODS AND APPARATUS FOR BILATERAL RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for renal neuromodulation of a human patient, the method comprising:
delivering a first ultrasound to neural fibers disposed adjacent a first renal blood vessel and innervating a first kidney,
wherein the first ultrasound inhibits neural traffic along the neural fibers innervating the first kidney; and

delivering a second ultrasound to neural fibers disposed adjacent a second renal blood vessel and innervating a second kidney,
wherein the second ultrasound inhibits neural traffic along the neural fibers innervating the second kidney,

wherein inhibiting neural traffic along the neural fibers innervating the first kidney and the neural fibers innervating the
second kidney results in a therapeutically beneficial reduction in central sympathetic overactivity of the patient.

US Pat. No. 9,060,755

NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS

Medtronic Ardian Luxembou...

1. A method for treating a patient, comprising:
locating a cryotherapeutic applicator intravascularly at a treatment site within or otherwise proximate a renal artery, wherein
the applicator includes a balloon at a distal portion of an elongated shaft;

transporting liquid refrigerant distally through a supply tube extending along a length of the shaft;
expanding the refrigerant through orifices longitudinally spaced apart along a portion of the supply tube within the balloon;
and

exhausting gaseous refrigerant proximally through an exhaust passage within the balloon,
wherein the portion of the supply tube within the balloon is helically wound around the exhaust passage such that expanding
the refrigerant through the orifices directs the refrigerant toward a helical region of the balloon and thereby cools an adjacent
helical region of tissue at the treatment site.

US Pat. No. 9,309,550

ANALYTE SENSORS HAVING NANOSTRUCTURED ELECTRODES AND METHODS FOR MAKING AND USING THEM

Medtronic MiniMed, Inc., ...

1. A method of sensing glucose within the body of a mammal, the method comprising implanting a glucose sensor into a mammal,
wherein the glucose sensor comprises:
a base layer;
a conductive layer disposed upon the base layer wherein the conductive layer includes a working electrode comprising a plurality
of conductive nanotubes;

an analyte sensing layer comprising glucose oxidase disposed on the conductive nanotubes, wherein the glucose oxidase generates
hydrogen peroxide in the presence of glucose; and

an analyte modulating layer disposed on the analyte sensing layer, wherein the analyte modulating layer:
modulates the diffusion of glucose therethrough; and
includes a composition of matter comprising a hydrophilic comb-copolymer having a central chain and a plurality of side chains
coupled to the central chain, wherein at least one side chain comprises a silicone moiety; and

sensing an alteration in electrical potential at the working electrode that results from hydrogen peroxide produced by the
glucose oxidase in the presence of glucose;

and correlating the alteration in electrical potential with the presence of glucose, so that glucose is sensed.

US Pat. No. 9,199,043

SYRINGE PISTON WITH CHECK VALVE SEAL

Medtronic MiniMed, Inc., ...

1. A syringe piston comprising:
a piston body having a fluid end and an actuator end opposite the fluid end;
a piston seal coupled to the piston body and located between the fluid end and the actuator end, wherein the piston seal forms
an interference fluid seal with an interior wall of a syringe barrel;

a check valve seal coupled to the piston body and positioned such that the piston seal is located between the check valve
seal and the actuator end, the check valve seal having a major outer surface that faces a main fluid chamber of the syringe
barrel; and

a gas entrapment zone defined between the check valve seal and the piston seal, wherein the check valve seal allows one-way
gas flow from the main fluid chamber of the syringe barrel and into the gas entrapment zone, and the piston seal inhibits
or prevents gas flow from the gas entrapment zone.

US Pat. No. 9,320,470

METHOD AND/OR SYSTEM FOR SENSOR ARTIFACT FILTERING

Medtronic Minimed, Inc., ...

1. A method comprising:
obtaining a sensor signal from a blood glucose sensor of a sensor component of an apparatus, the sensor signal being representative
of a blood glucose concentration;

mapping a measurement of noise associated with the sensor signal to one of three or more discrete levels or values;
selecting an output signal for use in determining an estimate of the blood glucose concentration from among a plurality of
distinct signal-filter paths arranged concurrently based, at least in part, on the one of three or more discrete levels or
values;

generating one or more commands for an insulin delivery component of the apparatus based, at least in part, on the estimate
of the blood glucose concentration; and

transmitting the generated one or more commands to the insulin delivery component to regulate a rate of fluid infusion into
a body.

US Pat. No. 9,393,363

INSERTION DEVICE SYSTEMS AND METHODS

MEDTRONIC MINIMED, INC., ...

1. An insertion system, the insertion system comprising:
a housing;
a piercing member arranged partially within the housing, the piercing member having a piercing end located outside of the
housing for piercing a membrane, the piercing member having a hollow interior for conveying fluidic media; and

a compliant material arranged within the housing to support the piercing member and attach the piercing member to the housing,
the compliant material for allowing articulation of the piercing member relative to the housing in a case where the piercing
member is in the membrane and moved relative to the housing;

wherein the piercing member extends through the compliant material and has a first end located on an opposite side of the
compliant material with respect to the piercing end of the piercing member.

US Pat. No. 9,393,399

SEALING ASSEMBLY FOR A FLUID RESERVOIR OF A FLUID INFUSION DEVICE

Medtronic MiniMed, Inc., ...

1. A sealing element for a fluid infusion device comprising a hollow fluid delivery needle, the sealing element comprising:
a base section;
a retractable body section extending from the base section;
a tip section extending from the retractable body section, wherein the retractable body section is between the base section
and the tip section;

a needle cavity formed in the retractable body section and continuing through the base section to define a needle opening
in the base section, the needle cavity sized to receive the hollow fluid delivery needle;

a self-sealing slit formed in the tip section to accommodate the hollow fluid delivery needle when the sealing element is
in a retracted position;

a guide channel in communication with the needle cavity and the self-sealing slit, the guide channel located between an end
of the needle cavity and the self-sealing slit, wherein the guide channel leads a tip of the hollow fluid delivery needle
into the self-sealing slit during retraction of the sealing element; and

a needle seal located in the guide channel and positioned between the self-sealing slit and the needle cavity to form a fluid
seal around the hollow fluid delivery needle to fluidly separate the needle cavity from the guide channel.

US Pat. No. 9,067,078

HERMETIC SEALING METHOD FOR A BATTERY FILLPORT USING SEALING MEMBER

Medtronic, Inc., Minneap...

5. The method of claim 1, wherein sealing the aperture comprises creating a continuous line seal in the shape of a closed loop about the sealing member
between the outer surface of the sealing member and the inner surface of the aperture.

US Pat. No. 9,345,530

DEVICES, SYSTEMS AND METHODS FOR EVALUATION AND FEEDBACK OF NEUROMODULATION TREATMENT

Medtronic Ardian Luxembou...

1. A method for evaluation and feedback of a neuromodulation treatment, the method comprising:
placing a first energy delivery element carried by an intravascular catheter at a treatment site within a renal blood vessel
of a human patient;

increasing energy delivery to the first energy delivery element, wherein energy delivery is increased to a pre-determined
first power level over a first period of time, and wherein the first energy delivery element is positioned to deliver energy
to target neural fibers proximate to a wall of the renal blood vessel;

maintaining energy delivery at the first power level for a second period of time;
increasing energy delivery to a second predetermined power level if the temperature value is less than a preset threshold
temperature following the second period of time;

obtaining a set of treatment data corresponding to a completed treatment performed using the first energy delivery element;
evaluating the set of treatment data in view of one or more criteria to determine if a valuation of the completed treatment
is within a pre-determined range; and

providing an indication as to whether the valuation of the completed treatment is within the pre-determined range.

US Pat. No. 9,326,854

DELIVERY SYSTEM WITH PACING ELEMENT

Medtronic Vascular Galway...

1. A medical device delivery assembly, the assembly comprising:
a catheter-based delivery system having,
an electrical pacing element at a tip region of the catheter-based delivery system,
a capsule disposed proximal of the tip region,
a shaft extending proximally from the tip region; and
a prosthetic heart valve disposed in the capsule and over the shaft,
wherein the tip region including the electrical pacing element is removably attached to the shaft at a distal end of the shaft
such that the tip region with the electrical pacing element is configured to be removed from the delivery system, wherein
the electrical pacing element is an implantable pacemaker or an electrode, wherein the electrical pacing element is configured
to pace the heart.

US Pat. No. 9,056,156

MEDICAL DEVICES COMPRISING POLYMERIC DRUG DELIVERY SYSTEMS WITH DRUG SOLUBILITY GRADIENTS

Medtronic Vascular, Inc.,...

1. A method of preparing a drug solubility gradient comprising a drug admixed with a polymer, the method comprising:
preparing a first monomeric charge solution comprising at least one monomer under conditions that promote polymerization;
preparing at least one additional monomeric charge solution comprising at least one monomer;
contemporaneously initiating polymerization of the at least one monomer of the first monomeric charge solution while adding
said additional monomeric charge solution to said first charge monomeric solution; and

reacting said first monomeric charge solution and said additional monomeric charge solution until the desired degree of polymerization
of the polymer has been reached.

US Pat. No. 9,439,726

METHODS FOR THERAPEUTIC RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for treating a human patient with a diagnosed condition or disease associated with cardio-renal function, the
method comprising:
positioning a nerve modulation device within renal vasculature of the patient and in the vicinity of post-ganglionic neural
fibers that innervate a kidney of the patient; and

reducing neural communication to and from the kidney by at least partially ablating the neural fibers of the patient via the
nerve modulation device,

wherein the kidney continues to secrete renin in the patient after reducing neural communication with the nerve modulation
device,

wherein reducing neural communication to and from the kidney results in improved cardio-renal function of the patient.

US Pat. No. 9,204,916

CRYOGENIC BALLOON DEVICE WITH RADIOFREQUENCY TIP

Medtronic CryoCath LP, T...

1. A medical device, comprising:
an elongate catheter body including a proximal portion coupled to a handle and a distal portion;
a cryogenic treatment region coupled to the distal portion of the catheter body; and
at least one of a radiofrequency treatment region and an electroporation treatment region coupled to the distal portion of
the catheter body at a location that is distal to the cryogenic treatment region and defining an outer surface of and a distal
tip of the medical device.

US Pat. No. 9,399,115

CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

Medtronic Ardian Luxembou...

1. A neuromodulation catheter, comprising:
an elongate shaft including—
two or more first cut shapes, the first cut shapes being configured to at least partially resist deformation in response to
compression on the shaft along a longitudinal axis of the shaft, tension on the shaft along the longitudinal axis, and torsion
on the shaft in a first circumferential direction perpendicular to the longitudinal axis, and

two or more second cut shapes, the second cut shapes being configured to at least partially resist deformation in response
to compression on the shaft along the longitudinal axis, torsion on the shaft in the first circumferential direction, and
torsion on the shaft in a second circumferential direction opposite to the first circumferential direction; and

a neuromodulation element operably connected to the shaft via a distal end portion of the shaft,
wherein—
the first and second cut shapes are interspersed along a helical path extending about the longitudinal axis,
the first cut shapes are less resistant to deformation in response to torsion on the shaft in the second circumferential direction
than are the second cut shapes, and

the second cut shapes are less resistant to deformation in response to tension on the shaft along the longitudinal axis than
are the first cut shapes.

US Pat. No. 9,289,255

METHODS AND APPARATUS FOR RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for monitoring renal neuromodulation, the method comprising:
advancing a catheter into a vessel of a patient, the catheter comprising a distal section and a plurality of electrodes at
the distal section;

applying a stimulation electric field to a tissue of the patient;
monitoring a physiologic response to the stimulation electric field indicating in the tissue the presence of a neural fiber
that innervates a kidney; and

applying a denervating electric field to the neural fiber via the catheter to inhibit neural activity along the neural fiber,
wherein the denervating electric field is applied when the distal section of the catheter is in a helical configuration apposing
an interior wall of the vessel.

US Pat. No. 9,199,030

INFUSION MEDIUM DELIVERY DEVICE AND METHOD WITH DRIVE DEVICE FOR DRIVING PLUNGER IN RESERVOIR

Medtronic MiniMed, Inc., ...

1. A medical device for delivering an infusion medium to a user, the medical device comprising:
a first housing portion adapted to be carried by a user;
a second housing portion configured to be selectively operatively engaged with and disengaged from the first housing portion;
a reservoir connected to one of the first and second housing portions;
at least one of a drive device or a needle inserting device supported by the other of the first and second housing portions
relative to the respective housing portion to which the reservoir is connected, such that upon the first and second housing
portions being operatively engaged, the reservoir is operatively coupled to at least one of the drive device or the needle
inserting device;

a first magnet supported on the first housing portion; and
a second magnet supported on the second housing portion in a position to magnetically interact with the first magnet upon
the first and second housing portions being improperly aligned when brought toward each other for operative engagement;

wherein the first and second magnets are positioned relative to each other so as to impart a repelling force directed toward
properly aligning the first and second housing portions for operative engagement.

US Pat. No. 9,125,917

FLUOCINOLONE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER

Warsaw Orthopedic, Inc., ...

1. An implantable drug depot for reducing or treating pain, inflammation, and/or tissue transplant rejection in a patient
in need of such treatment, the implantable drug depot comprising fluocinolone or a pharmaceutically acceptable salt thereof
in an amount from about 0.5 wt. % to about 25 wt. % of the drug depot, and at least one biodegradable polymer having an inherent
viscosity of 0.6 dL/g to 0.8 dL/g comprising poly(lactide-co-glycolide), D-lactide, D,L-lactide, L-lactide, D,L-lactide-caprolactone,
or D,L-lactide-glycolide-?-caprolactone or a combination thereof, wherein the drug depot is implanted by injection and has
a surface that releases a burst dose of the fluocinolone or the pharmaceutically acceptable salt thereof in an amount of 0.001
?g to 5 ?g within 24 hours at a site beneath the skin, and the depot releases an effective amount of the fluocinolone or a
pharmaceutically acceptable salt thereof over a period of at least fifty days, and the drug depot has a modulus of elasticity
from about 2×105 dynes/cm2 to about 5×105 dynes/cm2, and a particle size from about 10 to about 200 micrometers, and the drug depot further comprises mPEG.

US Pat. No. 9,095,463

STENT-GRAFT DELIVERY HAVING A TIP CAPTURE MECHANISM WITH ELONGATED CABLES FOR GRADUAL DEPLOYMENT AND REPOSITIONING

Medtronic Vascular, Inc.,...

1. A stent-graft delivery system comprising:
an elongate shaft;
a plurality of elongate cables, wherein each cable extends over the elongate shaft and includes a first end, an intermediate
portion configured to engage endmost crowns of a stent of a stent-graft prosthesis, and a second end that extends distally
beyond the stent-graft prosthesis;

a guiding assembly disposed over the elongate shaft;
a distal tip assembly coupled to a distal end of the elongate shaft, the distal tip assembly and the guiding assembly being
moveable relative to each other, wherein a portion of the distal tip assembly extends proximally over an outer surface of
a distal portion of the guiding assembly and constrains the second ends of the cables between the outer surface of the distal
portion of the guiding assembly and an inner surface of the portion of the distal tip assembly in a first relative position
of the distal tip assembly and the guiding assembly and wherein the distal tip assembly does not constrain the second ends
of the cables in a second relative position of the distal tip assembly and the guiding assembly,

wherein, in the first relative position of the distal tip assembly and the guiding assembly, tension on the cables can be
selectively reduced for gradual continuous expansion of the endmost crowns of the stent or can be selectively increased for
gradual continuous radial contraction of the endmost crowns of the stent.

US Pat. No. 9,061,115

METHODS AND APPARATUS FOR PROVIDING AN ARTERIOVENOUS FISTULA

Medtronic Vascular, Inc.,...

1. A method of creating an artificial arteriovenous fistula between an artery and an adjacent vein of a patient comprising
the steps of:
inserting a distal end of a delivery device transversely through a first location on a wall of the artery into a lumen thereof;
exposing at least a piercing end of a hollow spiral shunt from the distal end of the delivery device within the lumen of the
artery, wherein the spiral shunt defines a fluid passageway between proximal and distal ports thereof;

rotating and distally advancing the delivery device to pierce the artery wall at a second location generally opposite the
first location with the spiral shunt piercing end;

after piercing the artery wall at the second location, rotating and distally advancing the delivery device to pierce a wall
of the adjacent vein with the spiral shunt piercing end; wherein during the step of rotating and distally advancing the delivery
device, the spiral shunt is corkscrewed through the wall of the artery and the wall of the vein; and

releasing the spiral shunt from the delivery device such that the proximal port of the spiral shunt resides within the artery
lumen and the distal port of the spiral shunt resides within a lumen of the vein, wherein the fluid passageway of the spiral
shunt forms the artificial arteriovenous fistula to permit blood flow between the artery and the vein.

US Pat. No. 9,308,321

INFUSION DEVICE HAVING GEAR ASSEMBLY INITIALIZATION

Medtronic MiniMed, Inc., ...

1. An infusion device comprising:
a housing to receive a shaft coupled to a plunger disposed in a reservoir;
a gear assembly including a first gear to engage the shaft and a worm gear coupled to the first gear, the first gear having
rotational freedom in a direction opposite a delivery direction, the worm gear exhibiting axial displacement in a first direction
in response to rotation of the first gear in the direction opposite the delivery direction;

a force sensor aligned with an axle of the worm gear;
a motor having a rotor coupled to the gear assembly; and
a control module coupled to the motor to operate the motor to displace the axle of the worm gear in a second direction opposite
the first direction and away from the force sensor in response to the reset condition.

US Pat. No. 9,284,648

PROCESS AND MATERIAL SOLUTION TO REDUCE METAL ION RELEASE FOR IMPLANTABLE MEDICAL DEVICE APPLICATION

Medtronic, Inc., Minneap...

1. A treated alloy composition comprising cobalt, nickel, molybdenum and chromium, wherein the alloy surface has increased
concentrations of molybdenum and chromium within at least the first 2 nm of the depth of the surface, wherein the alloy surface
concentration of molybdenum is from about 2.2 atomic percent to about 3.9 atomic percent and the concentration of chromium
is from about 10.4 atomic percent to about 17.5 atomic percent.

US Pat. No. 9,179,860

DETERMINING A LOCATION OF A MEMBER

Medtronic, Inc., Minneap...

1. A system to locate and determine a position of portions of an instrument in a volume, comprising:
an elongated and flexible single member extending a length between a first end and a second terminal end;
a first position element positioned near the first end of the elongated and flexible single member;
a second position element positioned near the second terminal end of the elongated and flexible single member;
a plurality of third position elements positioned along at least a portion of the length of the elongated and flexible single
member between the first end and the second terminal end, wherein the plurality of third position elements is configured to
allow for determination of a resolution of a geometry of the elongated and flexible single member;

a set of axis generation electrodes configured to be positioned on a surface of the volume;
a driver to inject a current at a selected first frequency into the volume between the set of axis generation electrodes;
a processor operable to evaluate an electrical property sensed with the first position element, the second position element,
and at least a sub-plurality of the third position elements of the plurality of the third position elements based on the injected
current into the volume;

wherein the elongated and flexible single member is operable to flex between the first position element and the second position
element such that the first position element and the second position element are not aligned;

wherein the first position element, the second position element, and at least the sub-plurality of the third position elements
of the plurality of the third position elements are operable to sense the electrical property within the volume due to the
injected current into the volume between the set of axis generation electrodes and the processor is configured to execute
instructions to determine a geometry of at least a portion of the elongated and flexible single member between the first end
and the second terminal end based at least on the sensed electrical property with the at least the sub-plurality of the third
position elements;

wherein the processor is configured to execute instructions to determine the position of at least one of the first position
element, the second position element, or the plurality of third position elements using only the processor and at least one
of the first position element, the second position element, the plurality of third position elements, or a fourth position
element and to determine if an anomalous current at an anomalous frequency is present within the patient other than the selected
first frequency, wherein the anomalous frequency is an interfering frequency.

US Pat. No. 9,320,503

DEVICES, SYSTEM, AND METHODS FOR GUIDING AN OPERATIVE TOOL INTO AN INTERIOR BODY REGION

Medtronic Vascular, Inc.,...

1. A surgical guide device comprising
a flexible guide tube comprising a main lumen defining a guide passage and at least one control lumen separate from the main
lumen;

a handle coupled to the guide tube, the handle comprising a proximal opening in communication with the guide passage through
which a separate operative tool can be advanced through a vascular system; and

a steering assembly comprising
a deflecting element at least partially within the control lumen and coupled to a distal end region of the flexible guide
tube to apply a deflecting force to bend the distal end region;

an actuator configured to rotate about the longitudinal axis of the guide device and rotatable by a single-handed operation;
and

a linkage system coupling the actuator to the deflecting element to apply the deflecting force in response to operation of
the actuator, the linkage system including a rack, a gear train, and a pickup reel, the gear train coupled between the rack
and the pick up reel, a proximal end of the deflecting element coupled to the pickup reel, the linkage system being operative
to translate rotation of the actuator into linear movement of the rack into rotation of the gear train and the pickup reel
to wind or unwind the deflecting element to apply the deflecting force to the distal end region of the deflecting element,
wherein the linkage system is positioned within the handle and amplifies the amount of deflecting force.

US Pat. No. 9,254,350

IMPLANTABLE MEDICAL DEVICES HAVING BIOABSORBABLE PRIMER POLYMER COATINGS

Medtronic Vascular, Inc.,...

1. An implantable medical device comprising:
a metallic framework;
a coating comprising a bioabsorbable primer polymer located on top of and in contact with said metallic framework;
a drug-polymer bioabsorbable coating comprising a drug and a bioabsorbable polymer located on top of and in contact with said
bioabsorbable primer polymer coating; and

wherein said bioabsorbable primer polymer has a molecular weight that is less than or equal to about 50,000 g/mol.

US Pat. No. 9,192,738

DEVICES AND METHODS FOR CRIMPING MEDICAL DEVICES

Medtronic Vascular Galway...

1. A crimping device for use with a medical device that is to be delivered to an implantation site within a patient via a
catheter-based delivery device, the medical device comprising a frame that comprises struts that define openings and comprising
a soft layer coupled to the frame, the crimping device comprising:
a force-applying surface configured to compress the entire medical device to a compressed delivery configuration for loading
within the catheter-based delivery device by applying a force to an outer surface of the medical device; and

at least one protruding element extending from the force-applying surface and arranged to least partially extend into one
of the openings defined by the struts while the medical device is being crimped,

wherein the extension of the at least one protruding element at least partially into one of the openings prevents at least
a portion of the soft layer of the medical device from protruding between struts of the frame of the medical device while
the device is being crimped.

US Pat. No. 9,084,590

DEVICE AND METHOD FOR IMPROVED SAFETY AND EFFICACY FOR CRYOABLATION

Medtronic CryoCath LP, T...

1. A method of creating a lesion in tissue, the method comprising:
positioning a distal end of a medical device proximate an area of target tissue; and
operating a control unit according to a treatment cycle, the treatment cycle including:
supplying coolant to the distal portion of the medical device at a first flow rate, the first flow rate causing the distal
portion of the medical device to reach a first temperature;

supplying coolant to the distal portion of the medical device at a second flow rate, the second flow rate causing the distal
portion of the medical device to reach a second temperature, the second temperature being higher than the first temperature
and the second flow rate being lower than the first flow rate; and

supplying coolant to the distal portion of the medical device at a third flow rate, the third flow rate causing the distal
portion of the medical device to reach a third temperature, the third temperature being lower than the second temperature,
and the third flow rate being lower than the first flow rate but higher than the second flow rate,

the first and third temperatures being sufficiently low so as to ablate the target tissue and cause cryoadhesion between the
distal portion of the medical device and the target tissue, the second temperature being above a temperature at which ablation
occurs and below a temperature at which cryoadhesion is broken.

US Pat. No. 9,492,635

CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

Medtronic Ardian Luxembou...

1. A neuromodulation catheter, comprising:
an elongate shaft including—
a first helically wound elongate member having a series of first windings at least partially forming a first tubular structure
that includes a transition region, wherein an average helix angle of the first windings distal to the transition region is
different than an average helix angle of the first windings proximal to the transition region, and

a second helically wound elongate member having a series of second windings at least partially forming a second tubular structure
concentrically disposed around the first tubular structure;

a neuromodulation element operably connected to the shaft via a distal end portion of the shaft; and
a biocompatible jacket at least partially encasing the first and second tubular structures.

US Pat. No. 9,089,292

CALIBRATION OF GLUCOSE MONITORING SENSOR AND/OR INSULIN DELIVERY SYSTEM

Medtronic Minimed, Inc., ...

1. A method comprising:
obtaining, from a blood-glucose sensor, one or more blood glucose sensor measurements;
obtaining one or more reference sample signals based at least in part on one or more blood glucose reference samples;
combining, via a processor, said one or more reference sample signals and said one or more blood glucose measurements to provide
a plurality of blood glucose reference sample-sensor measurement pairs;

estimating one or more parameters of a plurality of probability models based, at least in part, on said blood glucose reference
sample-sensor measurement pairs;

determining a plurality of functions for estimating a blood-glucose concentration in a patient from sensor measurements based,
at least in part, on said estimated one or more parameters of said plurality of probability models;

for each of said plurality of functions, estimating a sensor glucose concentration value by application of said function to
provide a plurality of estimated sensor glucose concentration values, each of said estimated sensor glucose concentration
values being generated by a corresponding one of said plurality of functions; and

determining a composite sensor glucose concentration value for the patient based, at least partly, on a combination of said
plurality of estimated sensor glucose concentration values.

US Pat. No. 9,066,713

NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS

Medtronic Ardian Luxembou...

1. A cryotherapeutic device, comprising;
an elongated shaft having a distal portion configured to be located intravascularly at a treatment site in a renal artery
or ostium;

a supply lumen extending along a length of the shaft, the supply lumen being configured to receive liquid refrigerant;
a cooling assembly at the distal portion of the shaft, the cooling assembly having a delivery state and a deployed state,
the cooling assembly including

an elongated support member extending along a length of the cooling assembly,
an orifice in fluid communication with the supply lumen, and
an applicator configured to cause therapeutically-effective cryogenic renal-nerve modulation when the cooling assembly is
in the deployed state and when the cooling assembly receives refrigerant from the supply lumen, the applicator having a balloon
that defines a chamber, the balloon having

a heat-transfer portion in fluid communication with the orifice, the heat-transfer portion being non-circumferential at longitudinal
segments disposed along the length of the cooling assembly and being spaced apart from the support member when the cooling
assembly is in the deployed state, and

an attachment portion attached to the support member; and
an occlusion member spaced apart proximally from the applicator, the occlusion member having a collapsed state, an expanded
state, and a cross-sectional dimension that fully occludes the renal artery or ostium proximal to the treatment site when
the occlusion member is in the expanded state.

US Pat. No. 9,265,488

SUTURING DEVICE AND METHOD FOR SEALING AN OPENING IN A BLOOD VESSEL OR OTHER BIOLOGICAL STRUCTURE

Medtronic Vascular, Inc.,...

17. A method of positioning a suture at an arteriotomy of a vessel wall of a vessel, wherein the method includes the steps
of:
positioning a distal end of a suturing device through the arteriotomy, wherein the suturing device includes a handle, an elongated
body, coupled to a distal end of the handle, and a shaft slidingly disposed within the handle and the elongated body, wherein
an expandable suture capture component is mounted on a distal portion of the shaft and is in a compressed configuration in
which the expandable suture capture component is disposed within the elongated body;

expanding the expandable suture capture component to a deployed configuration in which the expandable suture capture component
radially expands and extends away from the elongated body, wherein the expanded expandable suture capture component is positioned
within the vessel; and

distally extending at least one pair of needles of the suturing device from a loaded position in which the at least one pair
of needles is disposed within the elongated body to a deployed position in which the at least one pair of needles distally
extend from a distal end of the elongated body and penetrate through the vessel wall and through the expanded expandable suture
capture component, wherein a suture is slidingly disposed through the lumen of each needle and each suture is concurrently
carried with its respective needle during the step of distally extending the at least one pair of needles to the deployed
position.

US Pat. No. 9,522,030

PURGE PHASE FOR CRYOABLATION SYSTEMS

Medtronic CryoCath LP, T...

1. A method of purging a cryotreatment fluid flow path comprising:
(a) providing a cryotreatment system including a refrigerant source, a fluid delivery conduit in fluid communication with
the refrigerant source, a fluid injection element in fluid communication with the fluid delivery conduit, a fluid recovery
conduit in fluid communication with the fluid injection element, and a vacuum pump in fluid communication with and providing
a low pressure environment within the fluid recovery conduit;

(b) injecting refrigerant from the refrigerant source into the fluid delivery conduit for two seconds at a preselected injection
pressure that is less than a cryoablation minimum injection pressure, the refrigerant flowing from the fluid delivery conduit
through the fluid injection element and into the fluid recovery conduit;

(c) then evacuating refrigerant from the fluid recovery conduit by vacuum pressure generated by the vacuum pump for one second;
and

(d) then injecting refrigerant from the refrigerant source into the fluid delivery conduit at a pressure that is at least
the cryoablation minimum injection pressure.

US Pat. No. 9,445,867

METHODS FOR RENAL NEUROMODULATION VIA CATHETERS HAVING EXPANDABLE TREATMENT MEMBERS

Medtronic Ardian Luxembou...

1. A method, comprising:
intravascularly positioning a renal denervation catheter in a reduced profile delivery configuration within a renal artery
of a human patient and adjacent to renal nerves;

transforming an expandable member at a distal region of the catheter from the low-profile delivery configuration to a treatment
configuration, wherein, in the treatment configuration, the expandable member is sized and shaped to place a plurality of
electrodes arranged thereabout into apposition with an inner wall of the renal artery of the patient;

selectively energizing a first electrode group carried by the expandable member to deliver a first bipolar energy field to
the renal nerves; and

selectively energizing a second electrode group carried by the expandable member to deliver a second bipolar energy field
to the renal nerves,

wherein delivering the first and second bipolar energy fields blocks or attenuates neural signaling along the renal nerves.

US Pat. No. 9,213,010

APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS, DEVICES, AND RELATED METHODS

MEDTRONIC MINIMED, INC., ...

1. A method of calibrating a sensor during a period of sensor transition, the method comprising:
defining an electrochemical impedance spectroscopy (EIS)-based sensor status vector (V) for each one of a plurality of sensor
current (Isig)-blood glucose (BG) pairs;

monitoring the status vectors for the plurality of Isig-BG pairs over time;
detecting when there is a difference between a first status vector for a first Isig-BG pair and a subsequent status vector
for a subsequent Isig-BG pair, said first Isig-BG pair having assigned thereto a first offset value; and

if a magnitude of said difference is larger than a predetermined threshold, assigning a dynamic offset value for said subsequent
Isig-BG pair that is different from said first offset value so as to maintain a substantially linear relationship between
said subsequent Isig and said subsequent BG.

US Pat. No. 9,125,608

REAL-TIME SELF-CALIBRATING SENSOR SYSTEM AND METHOD

MEDTRONIC MINIMED, INC., ...

1. A system for calibrating a sensor of a characteristic monitoring system in real time by determining, and compensating for,
an IR drop across unwanted resistances in a cell, said sensor including a counter electrode, a reference electrode, and a
working electrode in communication with a user's blood or interstitial fluids to produce signals indicative of said characteristic,
the system comprising:
a first control unit having a potentiostat, said potentiostat including an operational amplifier connected in an electrical
circuit to maintain substantial equality between the magnitude of a measured voltage across the sensor's working and reference
electrodes and the magnitude of an applied voltage;

a current-interrupt switch electrically connected between the operational amplifier's output and the sensor's counter electrode
to provide a closed circuit when the switch is closed and an open circuit when the switch is opened; and

a second control unit including a microprocessor and connected in the electrical circuit to maintain substantial equality
between the magnitude of an optimally desired voltage across the sensor's working and reference electrodes and the magnitude
of an effective amount of potential in the cell that drives electrochemical reactions at the working electrode, said effective
amount of potential reflecting an adjustment for the magnitude of said IR drop, and said second control unit providing said
applied voltage as an input to the operational amplifier,

wherein the second control unit estimates the magnitude of the IR drop through linear regression of acquired open-circuit
samples of said measured voltage across the sensor's working and reference electrodes over time;

wherein the magnitude of said effective amount of potential in the cell is optimized by further subtracting therefrom the
magnitude of the open-circuit voltage across the sensor's working and reference electrodes; and

wherein the magnitude of said open-circuit voltage is obtained by allowing, while said switch remains open, the voltage between
the working and reference electrodes to stabilize to a steady-state value, and then measuring said steady-state value.

US Pat. No. 9,084,610

CATHETER APPARATUSES, SYSTEMS, AND METHODS FOR RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A catheter apparatus for intravascular renal neuromodulation, comprising:
an elongated shaft extending along an axis, the elongated shaft comprising a proximal portion and a distal portion, the distal
portion including an elongate first flexure zone, a second flexure zone distal of the first flexure zone, and a third flexure
zone adjacent to and extending distally beyond the second flexure zone;

an energy delivery element carried by and extending distally beyond the third flexure zone, wherein the energy delivery element
is configured to contact an intravascular tissue surface and deliver energy to renal nerves positioned adjacent to the intravascular
tissue surface; and

a control element coupled to the second flexure zone; and
an active cooling element comprising an infusion port in the energy delivery element, and wherein the infusion port is in
fluid communication with a thermal fluid infusion source,

wherein—
the control element is configured to apply a first force to the second flexure zone to control motion of the energy delivery
element in a plane including the axis and position the energy delivery element in contact with the intravascular tissue surface;

the energy delivery element is configured to apply energy via the intravascular tissue surface to ablate the renal nerves;
and

the active cooling element is configured to remove heat from the energy delivery element.

US Pat. No. 9,370,621

NEEDLE INSERTION SYSTEMS AND METHODS

MEDTRONIC MINIMED, INC., ...

1. A needle-inserting device comprising:
a housing having a flexible portion, an internal chamber, a longitudinal dimension, and an internal surface having an angled,
ramped or wedge-shaped portion;

a plunger arranged for movement within the internal chamber, in the direction of the longitudinal dimension of the housing,
from a first plunger position to a second plunger position;

a bias mechanism for imparting a bias force on the plunger when the plunger is in the first plunger position, wherein the
bias force is directed toward the second plunger position; and

a needle connected to the plunger for movement with the plunger; and
a tab connected to or integral with and the plunger and carried by the plunger, the tab having a tab end configured to retain
the plunger in the first plunger position, the tab end moveable relative to the housing;

an insert structure arranged for movement within the internal chamber of the housing with movement of the plunger from the
first plunger position to the second plunger position, the insert structure including a body through which the needle extends,
wherein at least one of the plunger or the body of the insert structure is arranged to engage the angled, ramped or wedge-shaped
portion of the housing and outwardly flex the flexible portion of the housing upon the insert structure being moved as the
plunger moves from the first plunger position to the second plunger position;

wherein upon movement of the tab end, the plunger is released from being retained in the first plunger position by the tab
end and moves with the tab end, relative to the housing, in the direction of the longitudinal dimension of the housing from
the first plunger position to the second plunger position under the bias force imparted by the bias mechanism to move the
needle to an insert position and outwardly flex the flexible portion of the housing.

US Pat. No. 9,338,819

VARIABLE DATA USAGE PERSONAL MEDICAL SYSTEM AND METHOD

MEDTRONIC MINIMED, INC., ...

15. A method of personal medical variable data usage for a patient comprising:
transmitting a value for a fixed interval index remote from the patient;
storing the fixed interval index at the patient;
generating self-care device data for the patient;
transmitting the self-care device data at a fixed interval;
receiving and storing the transmitted self-care device data;
storing an interval counter and incrementing the interval counter for each of the fixed intervals in which the transmitted
self-care device data is received;

generating a data cellular packet from overhead plus the stored self-care device data in response to determining that the
interval counter equals the fixed interval index;

transmitting the data packet from the patient over a cellular network, wherein the fixed interval index controls how often
data packets are transmitted; and

receiving, processing, and storing the transmitted data packet remote from the patient.

US Pat. No. 9,333,023

BALLOON CATHETER WITH DEFORMABLE FLUID DELIVERY CONDUIT

Medtronic CryoCath LP, T...

1. A method of thermally treating tissue, comprising:
positioning an expandable element of a medical device adjacent to the tissue, the medical device includes a guide wire lumen
at least partially disposed within the elongate body and at least partially disposed within the interior of the expandable
element;

delivering a fluid into an interior of the expandable element with a fluid delivery conduit to expand the expandable element,
the fluid delivery conduit being in a first geometric configuration, the fluid delivery conduit including a deflectable segment
defining a proximal end and a distal end with the proximal end being slidably and rotatably coupled to the guide wire lumen
and the distal end being immovably fixed to the guide wire lumen;

thermally treating a first region of the tissue with the expandable element;
transitioning the fluid delivery conduit from the first geometric configuration into a second geometric configuration; and
thermally treating a second region of the tissue with the expandable element.

US Pat. No. 9,226,709

ICE MESSAGE SYSTEM AND METHOD

Medtronic MiniMed, Inc., ...

1. A medical system for use with a patient, the system comprising:
a personal medical device attached to the patient, the personal medical device comprising:
a case attached to the patient;
a monitor contained in the case and operable to detect an emergency condition at the personal medical device; and
a processor contained in the case and operably connected to the monitor and operable to select an ICE message in response
to the emergency condition; and

a display operably connected to the personal medical device and operable to display the ICE message, the ICE message including
emergency contact information.

US Pat. No. 9,215,995

SENSOR SYSTEMS HAVING MULTIPLE PROBES AND ELECTRODE ARRAYS

Medtronic MiniMed, Inc., ...

1. An amperometric analyte sensor system comprising:
a probe platform;
a first probe coupled to the probe platform and adapted to be inserted in vivo, wherein the first probe comprises:
a first electrode array comprising a working electrode, a counter electrode and a reference electrode; and
a second electrode array comprising a working electrode, a counter electrode and a reference electrode;
a second probe coupled to the probe platform and adapted to be inserted in vivo, wherein the second probe comprises:
a third electrode array comprising a working electrode, a counter electrode and a reference electrode; and
a fourth electrode array comprising a working electrode, a counter electrode and a reference electrode;wherein the first, second, third and fourth electrode arrays are configured to be electronically independent of one another;
and
the system further comprises:
a processor;
a computer-readable program code having instructions, which when executed cause the processor to:
assess signal data obtained from each of the first, second, third and fourth electrode arrays against one or more reliability
parameters;

rank signal data from each of the first, second, third and fourth electrode arrays in accordance with the assessment against
the one or more reliability parameters; and

compute an analyte concentration based upon the ranking of signal data obtained from each of the first, second, third and
fourth electrode arrays.

US Pat. No. 9,468,497

METHODS FOR MONOPOLAR RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for treating hypertension in a human patient via renal denervation, the method comprising:
intravascularly placing a monopolar electrode at least substantially proximate to a post-ganglionic nerve that innervates
a kidney of a patient;

electrically coupling a ground electrode to an exterior of the patient; and
delivering an electric field between the monopolar electrode and the ground electrode such that the resulting electric field
attenuates neural communication along the post-ganglionic nerve,

wherein delivering the electric field results in a therapeutically beneficial reduction in blood pressure of the patient.

US Pat. No. 9,433,732

METHODS AND APPARATUSES FOR DETECTING OCCLUSIONS IN AN AMBULATORY INFUSION PUMP

MEDTRONIC MINIMED, INC., ...

1. An infusion pump for infusing fluid from a reservoir into a body of a user, the infusion pump comprising:
a housing;
a drive mechanism including a motor and one or more drive train components contained within the housing and operatively coupled
to the reservoir to deliver fluid from the reservoir through a fluid path into the body of the user;

one or more electronic components to measure a plurality of respective values of at least two different parameters associated
with the motor or one of the drive train components; and

a processor contained within the housing, wherein the processor calculates a respective average value based on said plurality
of measured values for each of the at least two different parameters, and wherein the processor adds said respective average
values to obtain a combined value and determines whether an occlusion has occurred in the fluid path of the infusion pump
by using the combined value.

US Pat. No. 9,387,077

CATHETER ASSEMBLY WITH PROSTHESIS CRIMPING AND PROSTHESIS RETAINING ACCESSORIES

Medtronic Vascular Galway...

1. A prosthesis retaining assembly for securing an implantable prosthesis to a catheter assembly, the prosthesis retaining
assembly comprising:
a first member including a central longitudinal axis, a hollow chamber and a prosthesis retaining slot configured to retain
a portion of the prosthesis, the retaining slot being configured to retain a portion of the prosthesis such that when the
portion of the prosthesis is retained within the retaining slot longitudinal movement of the prosthesis relative to the first
member is prevented, the retaining slot having a first opening at an interior surface of the first member defining the hollow
chamber; and

a second member positioned within the hollow chamber of the first member and comprising an enlarged portion, the second member
being movable relative to the first member between

a first position at which the enlarged portion is positioned adjacent to and obstructs a portion of the first opening of the
retaining slot preventing the portion of the prosthesis retained within the retaining slot from exiting the first opening
of the retaining slot in a radially inward direction towards the central longitudinal axis and

a second position at which the enlarged portion is moved relative to the retaining slot to create a gap between the second
member and the first opening of the retaining slot such that the portion of the prosthesis can pass through the first opening
of the retaining slot in a radially outward direction away from the central longitudinal axis.

US Pat. No. 9,301,863

PROSTHESIS DELIVERY APPARATUS AND METHODS

Medtronic Vascular, Inc.,...

1. A self-expanding prosthesis delivery system comprising:
an outer tubular structure having a proximal end and a distal end configured to receive a self-expanding prosthesis;
an inner tubular member adapted for tracking over a guidewire, having a proximal end portion fixed to a handle and a distal
end portion, and being disposed in said outer tubular structure, at least a portion of said outer tubular structure being
movable relative to said inner tubular member such that at least a portion of said outer tubular structure can be retracted,
while said inner tubular member is held in a fixed position relative to said outer tubular structure, said outer tubular structure
and inner tubular member being radially spaced from one another so as to form a fluid fillable space having first and second
ends;

a first sealing member fixedly secured to said inner tubular member at a location proximal to said distal end portion of said
inner tubular member to fluidly seal said first end of said fluid fillable space, said first sealing member extending from
said inner tubular member to said outer tubular structure and being in sealing engagement with said outer tubular structure
even during deployment of a self-expanding prosthesis therefrom; and

a second seal arranged at said second end of said fluid fillable space formed by said handle to fluidly seal said second end
of said fluid fillable space,

wherein said outer tubular structure, inner tubular member, first sealing member, and said second seal form a fluid fillable
chamber, which has a constant volume that remains constant when said outer tubular structure is retracted a sufficient distance
relative to said inner tubular member to deploy a self-expanding prosthesis.

US Pat. No. 9,078,636

CRYO SENSITIZING AGENTS FOR THE ENHANCEMENT OF CRYOTHERAPY

Medtronic CryoCath LP, T...

1. A method of treating tissue to enhance the effects of ablation comprising:
identifying tissue to receive ablation therapy;
treating the tissue with a temperature-sensitizing agent; and
activating an ablation therapy device proximate the treated tissue, the temperature-sensitizing agent being a temperature-sensitizing
adjuvant selected from the group consisting of: thermophysical adjuvants, chemotherapeutic adjuvants, vascular adjuvants,
immunomodulator adjuvants, and combinations thereof, and the temperature-sensitizing agent being applied to the tissue by
an applicator that is integrated with the ablation therapy device, the applicator being an ablation element having an outer
surface that is coated with a layer of temperature-sensitizing adjuvant and a layer of temperature-sensitive substrate material
between the ablation element and the layer of temperature-sensitizing adjuvant, the layer of substrate material readily separating
from the ablation element when substrate material is within a certain temperature range;

the ablation therapy being at least one of:
cryoablation and the ablation therapy device is a cryoablation device;
radiofrequency ablation and the ablation therapy device is a radiofrequency ablation device; and
combination thereof.

US Pat. No. 9,056,351

STENT WITH IMPROVED FLEXIBILITY AND METHOD FOR MAKING SAME

Medtronic Vascular, Inc.,...

1. A method for manufacturing a stent, the method comprising: forming a first continuous wire into a first circumferential
ring having an outer surface facing away from a longitudinal axis and having a sinusoidal shape defined by a plurality of
peaks connected to a plurality of valleys by a plurality of segments; forming a second continuous wire into a second circumferential
ring having an outer surface facing away from a longitudinal axis and having a sinusoidal shape defined by a plurality of
peaks connected to a plurality of valleys by a plurality of segments; deforming a peak of the first ring such that a deformed
peak portion is unitary with and flanked by non-deformed peak portions on opposite sides, the deformed peak portion having
i) an outer surface recessed below outer surfaces of the flanking non-deformed peak portions, and ii) an extension that protrudes
in a longitudinal direction away from the first ring and consists of displaced material of the first continuous wire; and
abutting and connecting the extension of the deformed peak portion to a valley of the second ring so as to space the non-deformed
peak portions from the valley; wherein said connecting comprises welding.

US Pat. No. 9,398,931

METHOD AND SYSTEM FOR PREVENTING NERVE INJURY DURING A MEDICAL PROCEDURE

Medtronic CryoCath LP, T...

1. A method of treating cardiac tissue, comprising:
stimulating a target tissue structure;
measuring a physiological response to the stimulation;
defining a threshold physiological response value based at least in part on the measured physiological response;
applying a thermal treatment regimen to a cardiac tissue region;
measuring a physiological parameter during the thermal treatment regimen application;
comparing the measured physiological parameter to the defined physiological response value threshold; and
adjusting the thermal treatment regimen in response to the comparison of the measured physiological parameter to the defined
physiological response value threshold.

US Pat. No. 9,320,589

ENDOVASCULAR ANEURYSM REPAIR SYSTEM

Medtronic Vascular, Inc.,...

1. A system comprising:
an intraluminal directing device sized and configured for introduction from a remote access site to a location within a blood
vessel lumen, the intraluminal directing device including a deflectable distal region sized and configured for manipulation
to orient the distal region with respect to different desired fastening sites within the blood vessel lumen;

a single helical tissue-piercing fastener having a proximal diagonal component extending across the diameter of the helical
tissue-piercing fastener; and

an intraluminal fastener applier including a driven component, a distal end of the intraluminal fastener applier comprising
a lumen configured to receive the helical tissue-piercing fastener, the intraluminal fastener applier having internal helical
grooves positioned along the entire length of the helical tissue-piercing fastener, the distal end of the driven component
comprising a fastener driver, a first portion of which is positioned proximal to and immediately adjacent the helical grooves
and the helical tissue-piercing fastener and is sized such that the helical tissue-piercing fastener cannot move proximally
past the fastener driver within the lumen of the intraluminal fastener applier and a second portion of which is configured
to engage the proximal diagonal component of the tissue-piercing fastener, the driven component being rotatable within the
lumen to cause the helical tissue-piercing fastener to rotate along the internal helical grooves of the lumen and out of the
distal end of the intraluminal fastener applier, and the intraluminal fastener applier being sized and configured to be introduced
along the intraluminal directing device.

US Pat. No. 9,283,305

HOLLOW TUBULAR DRUG ELUTING MEDICAL DEVICES

Medtronic Vascular, Inc.,...

1. A method of forming a medical device comprising the steps of:
forming an outer member over a core member, wherein the outer member has an outer surface and an inner surface, the inner
surface defining an outer member lumen such that the core member is disposed within the outer member lumen, the outer and
core members forming an elongate composite wire;

shaping the composite wire into a pattern by bending the composite wire into a waveform, wherein the pattern defines a stent
lumen;

forming openings through the outer member; and
after the step of shaping the composite wire into the pattern, exposing the composite wire to an etchant that reacts with
the core member to remove the core member from the outer member without adversely affecting the outer member.

US Pat. No. 9,114,032

METHOD OF MAKING A STENT

Medtronic Vascular, Inc.,...

1. A method of making a stent comprising the steps of:
receiving a dataset corresponding to a three-dimensional precursor stent;
forming a precursor stent using three-dimensional printing, wherein the precursor stent comprises a plurality of bands disposed
adjacent to each other, wherein each band comprises a plurality of struts connected by a plurality of crowns, and a plurality
of connectors connecting each band to an adjacent band;

processing the precursor stent to remove a selected number of the plurality of connectors between adjacent bands such that
at least one connector between each set of adjacent bands is removed and a gap is formed between the crowns of adjacent bands
where the selected number of the plurality of connectors were removed, wherein the selected number of the plurality of connectors
are thinner than the connectors not removed.

US Pat. No. 9,101,715

HANDHELD PERSONAL DATA ASSISTANT (PDA) WITH A MEDICAL DEVICE AND METHOD OF USING THE SAME

MEDTRONIC MINIMED, INC., ...

1. A medical system, comprising:
an external infusion device to deliver insulin to a user;
a characteristic meter to receive a blood sample from the user to determine a glucose level of the user;
a sensor set to determine body characteristics on a continuous, near continuous, or intermittent basis, wherein the body characteristics
include glucose levels of the user, the sensor set is coupled to a telemetered characteristic monitor transmitter to transmit
sensor data including the body characteristics, and wherein the sensor set includes one of an implantable sensor, a subdermal
sensor, and a subcutaneous sensor; and

a characteristic monitor, including
a display having a touch screen to display the sensor data received from the sensor set,
a sensor interface to wirelessly receive the sensor data from the sensor set via the telemetered characteristic monitor transmitter,
and

a microprocessor to program and obtain data from the external infusion device, to coordinate the sensor data from the sensor
set and meter data, including the determined glucose level of the user, from the characteristic meter with the data from the
external infusion device, to program and control the external infusion device, and to update delivery parameters of the external
infusion device,

wherein the characteristic meter transmits the meter data of the glucose level of the user from the characteristic meter to
the microprocessor of the characteristic monitor.

US Pat. No. 9,089,314

PARTIALLY COMPLIANT BALLOON DEVICE

Medtronic CryoCath LP, T...

1. An intravascular catheter for treating an area of tissue, the catheter comprising:
a first expandable member disposed on a portion of the catheter;
a second expandable member disposed within the first expandable member to define an interstitial region therebetween, the
second expandable member defining a cooling chamber;

a volume of an interstitial agent disposed within the interstitial region, the volume of the interstitial agent comprising
a gel, saline, contrast solution or a mixture thereof having a viscosity between approximately 0.6 cP and approximately 2000
cP, the volume of the interstitial agent being configured such that at least partial contact between the first and second
expandable members is achieved when at least a portion of the first expandable member is in contact with the area of tissue
during a treatment procedure, the contact involving a compressive force against the tissue that is atraumatic to the tissue;

a coolant flow path in fluid communication with the cooling chamber;
a cryogenic coolant source in fluid communication with the coolant flow path, the cryogenic coolant being circulated within
the cooling chamber when the first and second expandable members are at least partially in contact with each other during
the treatment procedure; and

an interstitial agent delivery flow path in fluid communication with the interstitial region,
the at least partial contact between the first and second expandable members providing greater thermal conductivity of the
first expandable member, such that the first expandable member reaches a temperature sufficient to cause tissue ablation when
the cryogenic coolant is circulated through the cooling chamber.

US Pat. No. 9,089,637

RESERVOIR PLUNGER HEAD SYSTEMS AND METHODS

MEDTRONIC MINIMED, INC., ...

1. A system for transferring fluidic media, the system comprising:
a plunger head moveable in an axial direction within a reservoir having an interior volume for containing fluidic media, the
plunger head comprising:

a first portion in contact with fluidic media when fluidic media is in the interior volume of the reservoir;
a second portion located on an opposite side of the first portion of the plunger head from the interior volume of the reservoir,
the second portion connectable to a plunger arm; and

a third portion located between the first portion and the second portion of the plunger head;
wherein the first portion, the second portion, and the third portion of the plunger head are supported for moving together
in the axial direction within the reservoir; and

at least one seal member positioned between the reservoir and the plunger head;
wherein the at least one seal member is positioned between the first portion and the second portion of the plunger head;
wherein the first portion of the plunger head has an outer diameter, the second portion of the plunger head has an outer diameter
and the third portion of the plunger head between the first portion and the second portion has an outer diameter that is reduced
relative to the outer diameters of the first portion and the second portion of the plunger head, and wherein the at least
one seal member comprises a seal located around the third portion of the plunger head; and

wherein the first portion comprises at least one protrusion arranged along an outer surface defined by the outer diameter
of the first portion, the at least one protrusion is configured for at least one of stabilizing the plunger head and controlling
the compression of the at least one seal member.

US Pat. No. 9,539,046

CRYOGENIC MEDICAL MAPPING AND TREATMENT DEVICE

Medtronic CryoCath LP, T...

1. A medical device, comprising:
an elongate body defining a fluid flow path;
an expandable member coupled to the elongate body in fluid communication with the fluid flow path, the expandable member having
a distal portion and a proximal portion;

a cryogenic fluid source in fluid communication with the fluid flow path and the expandable member, delivery of the cryogenic
fluid into the expandable member reducing the temperature of the expandable member to at least one of cool and ablate tissue
in contact with the expandable member; and

a plurality of electrodes on the expandable member, each of the plurality of electrodes being an elongate strip having a length
that extends between the distal portion of the expandable member and the proximal portion of the expandable member, the length
of each electrode being configured to both transmit ablation energy to ablate tissue in contact with the electrode and receive
electrical signals from tissue in contact with the electrode to obtain a map of electrical activity in the tissue.

US Pat. No. 9,233,203

MEDICAL NEEDLES FOR DAMPING MOTION

Medtronic MiniMed, Inc., ...

1. A needle structure for communicating fluid to a patient from an external fluid reservoir configured to contain a flowable
fluid and having a pierceable septum external to the patient, the needle structure comprising a hollow needle having a longitudinal
dimension, a first end affixed to the fluid reservoir, and a second end having a sharp end for inserting the needle into the
patient, wherein force applied to the first end of the needle pushes the needle through the pierceable septum to position
the needle in fluid flow communication with the fluid reservoir and to insert the second end of the needle into the patient,
the hollow needle further having a generally straight section extending along the longitudinal dimension adjacent the first
end, the generally straight section passing through the pierceable septum external to the patient, a passage along at least
a portion of its longitudinal dimension for conveying the flowable fluid to the patient and at least one bend along its longitudinal
dimension between the generally straight section and the second end that dampens movements of the second end with respect
to the first end, the needle being flexible at the at least one bend and flexes to dampen the transfer of motion from the
second end of the needle to the generally straight section of the needle.

US Pat. No. 9,204,840

REAL TIME SELF-ADJUSTING CALIBRATION ALGORITHM

Medtronic Minimed, Inc., ...

1. A method for filtering signals from a sensor comprising:
receiving a plurality of signal values from the sensor generated in response to a concentration of a substance;
at a processor, computing a quantifier of a variance of a measurement error based, at least in part, on a standard deviation
of an absolute value of consecutive data points within the plurality of signal values; and

at said processor, filtering the plurality of signal values with an adaptive filter, wherein the quantifier is an input to
the adaptive filter.

US Pat. No. 9,186,157

HIGH SPEED SURGICAL CUTTING INSTRUMENT

Medtronic Xomed, Inc., J...

1. A surgical cutting instrument for use with a motor having a drive mechanism, the instrument comprising:
an outer tube defining a proximal end, a distal end, a proximal region extending to the proximal end, a distal region extending
to the distal end, and a lumen extending from the proximal end to the distal end;

a bearing sleeve being substantially tubular in shape and defining a proximal terminus, a distal terminus, and an inner passage
extending from the proximal terminus to the distal terminus, at least a portion of the bearing sleeve secured within the lumen
of the outer tube with a plurality of exteriorly projecting ribs facing an inner surface of the outer tube;

an inner wire assembly defining a proximal section and a distal section, the inner wire assembly extending through the lumen
of the outer tube and through the inner passage of the bearing sleeve;

a cutting tip connected to the distal section of the inner wire assembly;
a coupling chuck adapted for connection to a drive mechanism of a motor, the coupling chuck being connected to the proximal
section of the inner wire assembly; and

a housing maintaining the proximal region of the outer tube and the coupling chuck, the housing being adapted for connection
to a motor.

US Pat. No. 9,486,577

FLUID RESERVOIR SEATING PROCEDURE FOR A FLUID INFUSION DEVICE

Medtronic MiniMed, Inc., ...

1. A method of seating a fluid reservoir in a housing of a fluid infusion device prior to establishing an outgoing fluid flow
path from the fluid reservoir, the fluid infusion device comprising a drive motor assembly, an actuation mechanism operatively
coupled to the drive motor assembly for actuation of a plunger of the fluid reservoir, and a force sensor operatively coupled
to the actuation mechanism, the method comprising:
detecting insertion of the fluid reservoir into the housing, wherein insertion of the fluid reservoir into the housing causes
a shaft of the plunger to engage the actuation mechanism;

after detecting insertion of the fluid reservoir, obtaining a first measure of force using the force sensor, wherein the first
measure of force is associated with interaction of the shaft with the actuation mechanism;

comparing the first measure of force to a first threshold force value;
when the first measure of force is greater than the first threshold force value, depressurizing the fluid reservoir;
after depressurizing the fluid reservoir, or when the first measure of force is not greater than the first threshold force
value, rewinding the drive motor assembly to achieve an equilibrium state for the fluid reservoir; and

after rewinding the drive motor assembly to achieve the equilibrium state, advancing the drive motor assembly to obtain an
initial seated state for the fluid reservoir.

US Pat. No. 9,468,766

SENSING AND ATRIAL-SYNCHRONIZED VENTRICULAR PACING IN AN INTRACARDIAC PACEMAKER

Medtronic, Inc., Minneap...

1. A medical device system, comprising:
an intracardiac pacemaker, the pacemaker comprising:
a sensing module configured to receive a cardiac electrical signal and detect a crossing of a first sensing threshold by the
cardiac electrical signal;

a pulse generator configured to generate and deliver a pacing pulse to the patient's heart via a pair of electrodes, and
a control module coupled to the sensing module and the pulse generator and configured to:
set a pacing escape interval timer to a first pacing escape interval in response to the cardiac electrical signal crossing
the first sensing threshold,

set a time limit in response to the cardiac electrical signal crossing the first sensing threshold, the time limit shorter
than the first pacing escape interval;

adjust the pacing escape interval timer in response to the cardiac electrical signal crossing a second sensing threshold higher
than the first sensing threshold within the time limit; and

control the pulse generator to deliver the pacing pulse if the first pacing escape interval expires.

US Pat. No. 9,308,382

IMPLANTABLE PULSE GENERATOR SYSTEMS AND METHODS FOR PROVIDING FUNCTIONAL AND/OR THERAPEUTIC STIMULATION OF MUSCLES AND/OR NERVES AND/OR CENTRAL NERVOUS SYSTEM TISSUE

MEDTRONIC URINARY SOLUTIO...

1. A system comprising:
an implantable electrical stimulation generator comprising:
a housing,
first circuitry carried within the housing and configured for wireless telemetry using at least one of UHF signals and VHF
signals,

an antenna coupled to the first circuitry and configured to at least one of receive or transmit the at least one of UHF signals
and VHF signals of the wireless telemetry,

a rechargeable battery carried within the housing, and
a power receiving coil carried within the housing, the power receiving coil configured to transcutaneously receive an externally
generated radio frequency magnetic field to recharge the rechargeable battery;

an external controller including second circuitry; and
a charging coil coupled to the second circuitry for generating the radio frequency magnetic field to transcutaneously recharge
the rechargeable battery via the second circuitry of the external programmer,

wherein the second circuitry of the external controller is configured to communicate with the antenna and first circuitry
of the implantable electrical stimulation generator via wireless telemetry using at least one of the UHF signals and the VHF
signals,

wherein, during a battery recharge period, and using the wireless telemetry, the implantable electrical signal generator is
configured to transmit status information to the external controller to allow the external controller to at least one of automatically
adjust the magnitude of the radio frequency magnetic field or generate an instruction to a user to reposition the charging
coil, and

wherein the adjustment of the magnitude of the radio frequency magnetic field comprises an adjustment of up to about 300 percent
of the initial magnitude.

US Pat. No. 9,144,493

VALVE PROSTHESIS DEPLOYMENT ASSEMBLY AND METHOD

Medtronic Vascular Galway...

1. A prosthesis delivery system comprising: a handle assembly comprising: a housing; and a control element comprising a thumbwheel
with an exterior surface having a plurality of protrusions located on the exterior surface; and a delivery catheter extending
from the handle assembly comprising: an outer sheath slidably controlled by the control element; and an inner shaft slidably
controlled by the control element, the inner shaft having a valve retainer; a track having an exterior surface and a plurality
of protrusions located on at least a portion of the exterior surface; an outer sheath carrier connected to the track and the
outer sheath; an inner shaft carrier, having an exterior surface and a plurality of protrusions located on at least a portion
of the exterior surface, connected to the inner shaft; and a secondary gear having an exterior surface and a plurality of
protrusions located on the exterior surface, wherein the protrusions on the thumbwheel directly interface with the protrusions
on the track, the protrusions on the track directly interface with the protrusions on the secondary gear, and the protrusions
on the secondary gear also directly interface with the protrusions on the inner shaft carrier.

US Pat. No. 9,101,310

GLUCOSE SENSOR SIGNAL STABILITY ANALYSIS

Medtronic Minimed, Inc., ...

1. A method comprising:
obtaining a series of samples of at least one sensor signal is responsive to a blood glucose level of a patient;
determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change
in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time, wherein said determining
comprises: iteratively updating a trend estimation at multiple samples of the series of samples of the at least one sensor
signal based at least partly on a trend estimation at a previous sample and a growth term; and

assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least
partly on the at least one metric assessing an underlying trend.

US Pat. No. 9,351,783

DIAGNOSTIC GUIDEWIRE FOR CRYOABLATION SENSING AND PRESSURE MONITORING

Medtronic CryoCath LP, T...

1. A method of occluding a pulmonary vein within a patient's body, the method comprising:
providing a medical device including a treatment element, a longitudinal axis, and an elongate body defining a distal portion,
a proximal portion, and a lumen therebetween, the treatment element being coupled to the distal portion of the elongate body;

providing a sensing component having a pressure sensor and one or more mapping elements, the sensing component being longitudinally
movable within the elongate body lumen, the sensing component having a hooped portion that is substantially orthogonal to
the longitudinal axis of the medical device and a distal tip portion having a J-shape, the J-shaped distal portion including
a linear portion located distal to the hooped portion and lying along an axis that is parallel to the longitudinal axis of
the elongate body;

providing a console processor in communication with the one or more mapping elements and the pressure sensor;
recording a first blood pressure measurement within the pulmonary vein with the pressure sensor, the pressure sensor transmitting
the first blood pressure measurement to the console processor;

then positioning the treatment element in contact with a cardiac tissue and positioning a distal portion of the sensing component
within the pulmonary vein;

then recording a second blood pressure measurement within the pulmonary vein using the pressure sensor after positioning the
treatment element in contact with the cardiac tissue, the pressure sensor transmitting the second blood pressure measurement
to the console processor;

comparing the first blood pressure measurement to the second blood pressure measurement, the console processor using the first
blood pressure measurement and the second blood pressure measurements to determine substantial occlusion of the pulmonary
vein by the treatment element when the second blood pressure measurement is within a first range and to determine partial
occlusion of the pulmonary vein by the treatment element when the second blood pressure measurement is within a second range,
the first range being higher than the second range.

US Pat. No. 9,345,528

LARGE AREA CRYOABLATION CATHETER WITH MULTI-GEOMETRY TIP ECG/CRYO MAPPING CAPABILITIES

Medtronic CryoCath LP, T...

1. A medical device, comprising:
an ablation element;
a thermally insulative sheath disposed within the ablation element;
a fluid injection tube disposed within a portion of the thermally insulative sheath; and
the ablation element passively transitioning from a substantially linear geometric configuration to a substantially circular
geometric configuration as the sheath is retracted proximally from a first position in which the sheath substantially encloses
the fluid injection tube to a second position in which a portion of the fluid injection tube extends a distance away from
the sheath, at least a portion of the fluid injection tube being biased in the substantially circular geometric configuration.

US Pat. No. 9,327,073

METHOD AND APPARATUS FOR DETECTING OCCLUSIONS IN AN AMBULATORY INFUSION PUMP

MEDTRONIC MINIMED, INC., ...

1. An infusion pump for infusing fluid from a reservoir into a body of a user, the infusion pump comprising:
a housing;
a drive mechanism including a motor and one or more drive components contained within the housing and operatively coupled
to the reservoir to deliver fluid from the reservoir through a fluid path into the body of the user;

one or more electronic components to take a series of measurements of a parameter associated with the motor or one of the
drive train components; and

a controller contained within the housing, wherein the controller filters the series of measurements to remove at least one
measurement from the series of measurements, calculates a weighted average of the remaining measurements in the series of
measurements by applying a weighting factor to each remaining measurement in the series of measurements to determine a weighted
value corresponding to each said remaining measurement and calculating the average of the weighted values, the weighting factor
applied to each said remaining measurement after the first remaining measurement being larger than the weighting factor for
the immediately preceding remaining measurement, compares the weighted average to a maximum threshold value, and determines
whether an occlusion has occurred in the fluid path of the infusion pump by determining whether the weighted average is greater
than the maximum threshold value.

US Pat. No. 9,192,758

EXTENSIBLE IMPLANTABLE MEDICAL LEAD WITH SIGMOIDAL CONDUCTORS

Medtronic, Inc., Minneap...

1. An extensible implantable electrical lead comprising:
a lead body having a proximal region and a distal region, the lead body formed of an extensible polymeric material that is
extensible between a first length and a second length, the second length being greater than the first length; and

a first plurality of electrical conductors disposed within the lead body and extending between the proximal region and the
distal region, the first plurality of electrical conductors are each electrically insulated and spaced apart from each other
and form a side-by-side co-planar first sigmoidal pattern between the proximal region and the distal region and arranged in
a first plane; and

further comprising a second plurality of electrical conductors disposed within the lead body and extending between the proximal
region and the distal region, the second plurality of electrical conductors are each electrically insulated and spaced apart
from each other and form a side-by-side co-planar second sigmoidal pattern from the proximal region to the distal region and
arranged in a second plane being different than the first plane, and the first plurality of electrical conductors are not
in the second plane, and the second plurality of electrical conductors are not in the first plane, and the first and second
planes are separate and parallel to each other,

wherein the first sigmoidal pattern is out of phase with the second sigmoidal pattern, and
a layer of the extensible polymeric material is disposed between and separating the first plurality of electrical conductors
from the second plurality of electrical conductors.

US Pat. No. 9,186,499

GROUNDING OF A SHIELD WITHIN AN IMPLANTABLE MEDICAL LEAD

MEDTRONIC, INC., Minneap...

1. A method of grounding a shield of an implantable lead that includes filars and electrodes at a proximal end and at a distal
end wherein the filars provide an electrical connection between the electrodes at the proximal end and the electrodes at the
distal end, comprising:
establishing a pathway capable of conducting electrical energy at radio frequencies between the shield at a first point along
the lead and a metal can of an implantable medical device, where the first point along the lead is spaced apart from a proximal
end of the lead that is positioned within a header of the implantable medical device such that an entire length of the pathway
and the first point are outside of the header.

US Pat. No. 9,560,787

REMOVABLE HEAT MANAGEMENT FOR RECHARGE COILS

Medtronic, Inc., Minneap...

1. A heat sink device comprising:
a material configured to absorb heat from an external energy transfer coil that transfers energy to a rechargeable power source
of an implantable medical device via an implantable energy transfer coil of the implantable medical device;

a first housing configured to house the material and mate with a second housing that houses the external energy transfer coil;
and

a coupling mechanism configured to removably attach the first housing of the heat sink device to the second housing of the
external energy transfer coil.

US Pat. No. 9,468,485

REAL-TIME LESION FORMATION ASSESSMENT

Medtronic CryoCath LP, T...

1. A method for creating permanent lesions in target tissue proximate a junction between a pulmonary vein and a left atrium,
the method comprising:
positioning a measuring device at least partially within the pulmonary vein;
obtaining a plurality of temperature measurements, with the measuring device, of blood at a location within the pulmonary
vein; and

comparing the plurality of temperature measurements to a set of reference temperatures that correlate temperature of the blood
to tissue temperature to provide a real-time temperature within a target tissue.

US Pat. No. 9,226,792

DEBRIDEMENT DEVICE AND METHOD

MEDTRONIC ADVANCED ENERGY...

1. A bipolar electrosurgical debridement device comprising:
a proximal region maintaining a housing;
a distal region opposite the housing;
an outer shaft defining a lumen and a distal end opposite the proximal region, wherein the distal end comprises an outer shaft
cutter defining a window in the outer shaft;

an inner shaft rotatably disposed within the lumen of the outer shaft, the inner shaft defining a distal portion opposite
the proximal region, the inner shaft further including an inner shaft cutter, operatively associated with the outer shaft
cutter and defining a cutting window in the inner shaft;

a bipolar electrode assembly comprising first and second electrodes that are electrically isolated from one another, each
electrode positioned at the distal region and electrically connected with a contact surface positioned at the proximal region
within the housing;

an indicator located remote from the distal region and associated with the housing to provide an indication of alignment of
the inner shaft with respect to the outer shaft;

a fluid source connector maintained by the housing and fluidly associated with the distal region; and
a button activation assembly comprising:
a button movable with respect to the housing to define an activation position;
an electrical contact within the housing coupled with the button, wherein upon operation of the button to the activation position,
electrical communication is afforded along an electrical pathway between a source of energy through each contact surface of
the first and second electrodes to the distal region while the button is maintained in the activation position and wherein
the electrical pathway is disconnected when the button is not in the activation position.

US Pat. No. 9,192,715

METHODS FOR RENAL NERVE BLOCKING

Medtronic Ardian Luxembou...

1. A method for treatment of a human patient diagnosed with hypertension, the method comprising:
positioning a catheter in a periarterial space of a renal artery and proximate a renal nerve of the patient; and
delivering a nerve blocking agent via the catheter to inhibit neural traffic along the renal nerve,
wherein delivering the nerve blocking agent results in a therapeutically beneficial reduction in blood pressure of the patient.

US Pat. No. 9,149,320

ISOLATION OF PULMONARY VEIN

Medtronic CryoCath LP, T...

1. A method for treating cardiac tissue, comprising:
substantially occluding at least a portion of a pulmonary artery with a first medical device to prevent blood flow into the
left atrium of a heart; and

thermally treating an ostium of a pulmonary vein with a second medical device while the at least a portion of the pulmonary
artery is substantially occluded by the first medical device, the second medical device including an expandable element and
a bypass flow path from a region distal of the expandable element to a region proximal of the expandable element, and a fluid
control element surrounding at least a portion of an external surface of the second medical device, the expandable element
surrounding at least a portion of the bypass path and longitudinal movement of the fluid control element selectively preventing
or allowing fluid flow through the bypass path.

US Pat. No. 9,456,869

METHODS FOR BILATERAL RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method of treating a disease of a human patient diagnosed with at least one of hypertension, heart failure, chronic kidney
disease, and renal failure by bilateral renal neuromodulation, the method comprising:
directing a first neuromodulatory energy to a first post-ganglionic neural fiber that innervates a first kidney of the patient
via an electric field that inhibits neural activity entering and exiting the first kidney; and

directing a second neuromodulatory energy to a second post-ganglionic neural fiber that innervates a second kidney of the
patient via an electric field that inhibits neural activity entering and exiting the second kidney,

wherein directing the first and second neuromodulatory energies to the first and second post-ganglionic neural fibers significantly
improves a measureable physiological parameter corresponding to the disease of the patient,

wherein at least one of the first kidney and second kidney continues to secrete renin in the patient after delivering the
electric field.

US Pat. No. 9,421,359

PROBE FOR IMPLANTABLE ELECTRO-STIMULATION DEVICE

MEDTRONIC BAKKEN RESEARCH...

1. A probe for an implantable electro-stimulation device, said probe comprising:
a distal end and a proximal end;
one or more electrodes on the probe;
a shield of conducting material covering a part of the probe, said shield extending from the vicinity of the one or more electrodes
towards the proximal end or towards the distal end of the probe; and

a layer of insulating material covering part of the shield in the vicinity of the one or more electrodes,
wherein an exposed area of the shield not covered by the layer of insulating material is at least one order of magnitude larger
than an area of one of the one or more electrodes, and is configured to be a return electrode for electrical stimulation current
from the electrodes, and wherein at least a portion of the layer of insulating material covering the part of the shield is
between the one or more electrodes and the exposed area of the shield.

US Pat. No. 9,283,318

FLANGED SEALING ELEMENT AND NEEDLE GUIDE PIN ASSEMBLY FOR A FLUID INFUSION DEVICE HAVING A NEEDLED FLUID RESERVOIR

Medtronic MiniMed, Inc., ...

1. A sealing assembly for a fluid infusion device that cooperates with a fluid reservoir having a reservoir port and a hollow
fluid reservoir needle at least partially located within the reservoir port, the sealing assembly comprising:
a reservoir port receptacle to receive the reservoir port, and comprising a proximal end, a distal end extending from the
proximal end, and a needle entry formed in the distal end to receive the hollow fluid reservoir needle;

a fluid chamber located at least partially in the reservoir port receptacle; and
a sealing component positioned in the reservoir port receptacle to cooperate with the fluid chamber, the sealing component
comprising:

a needle guide pin protruding from the proximal end of the reservoir port receptacle, wherein an end section of the needle
guide pin is sized to fit within the hollow fluid reservoir needle; and

a needle sealing element that cooperates with the hollow fluid reservoir needle and with the needle guide pin, the needle
sealing element comprising a base section adjacent to the fluid chamber, an end section opposite the base section, a neck
section between the base section and the end section, and a needle opening extending through the neck section; wherein:

when the reservoir port is engaged with reservoir port receptacle, the end section of the needle guide pin resides within
the hollow fluid reservoir needle, a portion of the hollow fluid reservoir needle resides within the needle opening, and the
needle sealing element forms a first seal around an exterior surface of the hollow fluid reservoir needle; and

when the reservoir port is disengaged from the reservoir port receptacle, the hollow fluid reservoir needle is decoupled from
the sealing component, a portion of the end section of the needle guide pin resides within the needle opening, and the needle
sealing element forms a second seal around an exterior surface of the needle guide pin.

US Pat. No. 9,227,055

MRI-SAFE IMPLANTABLE MEDICAL DEVICE

MEDTRONIC, INC., Minneap...

1. A method for providing electrical stimulation with an implantable stimulation system comprising:
providing a stimulator that produces electrical stimulation signals;
providing an implantable medical lead coupled to the stimulator, the implantable medical lead comprising an implantable elongate
insulating body, an electrode on a distal end of the insulating body, and an electrical conductor within the insulating body
that is connected to the electrode, the conductor having an absolute impedance of at least 15 ohms per centimeter at 64 MHz;
and

passing the electrical stimulation signals from the stimulator to the electrode through the conductor.

US Pat. No. 9,452,017

MULTI-ELECTRODE CATHETER ASSEMBLIES FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS

Medtronic Ardian Luxembou...

1. A renal denervation catheter for treatment of a human patient, the renal denervation catheter comprising:
a shaft having a proximal end and a distal end, wherein the distal end of the shaft is configured for intravascular delivery
over a guide wire to a renal blood vessel of the patient;

a pre-shaped helical structure disposed at or proximate to the distal end of the shaft, wherein the helical structure is configured
to transform between a low-profile delivery state and a deployed state tending to assume the shape of the pre-shaped helical
structure, and wherein the helical structure is composed, at least in part, of nitinol; and

a plurality of energy delivery elements carried by the helical structure,
wherein the shaft and the helical structure together define a guide wire lumen therethrough, and wherein—
the guide wire lumen is configured to slidably receive the guide wire to locate the helical structure at a target treatment
site within the renal blood vessel of the patient and to restrain the helical structure in the low-profile delivery state,
and

the helical structure is reversibly transformable from the delivery state to the deployed state by proximally moving the guide
wire through the guide wire lumen until a distalmost end of the guide wire is disposed within the helical structure.

US Pat. No. 9,301,839

TRANSCATHETER PROSTHETIC HEART VALVE DELIVERY DEVICE WITH RELEASE FEATURES

Medtronic CV Luxembourg S...

1. A delivery device for percutaneously deploying a stented prosthetic heart valve including a stent frame to which a valve
structure is attached, the device comprising:
a delivery sheath assembly terminating at a distal end and defining a lumen;
an inner shaft slidably disposed within the lumen; and
a capture assembly for selectively coupling the stented prosthetic heart valve relative to the inner shaft, the capture assembly
comprising:

a spindle attached to the inner shaft and including at least one coupling section defining a slot; and
a biasing member positioned in the slot and configured to transition from a deflected condition to a normal condition, wherein
the biasing member includes a fixed end and a free end rotatable about the fixed end, a radial projection of the free end
relative to a centerline of the inner shaft is greater in the normal condition than in the deflected condition,
wherein the delivery device is configured to provide:
a delivery state in which the delivery sheath assembly retains the stented prosthetic heart valve over the inner shaft and
the biasing member in the deflected condition, including a portion of the stented prosthetic heart valve engaged with the
at least one coupling section and the biasing member forced to the deflected condition; and

a deployment state in which the distal end of the delivery sheath assembly is withdrawn from covering at least a portion of
the capture assembly, wherein the biasing member transitions to the normal condition such that the free end rotates about
the fixed end to radially deflect the stent frame, and wherein the biasing member further includes an intermediate region
positioned between the free end and the fixed end, wherein the intermediate region projects radially to a greater distance
from the centerline than the fixed end in the normal and deflected conditions.

US Pat. No. 9,295,550

METHODS FOR DELIVERING A SELF-EXPANDING VALVE

Medtronic CV Luxembourg S...

1. A method for delivering a self-expandable heart valve, comprising:
approaching an inflow side of a cardiac valve with a valve delivery catheter, wherein the delivery catheter comprises:
a catheter body having an exterior surface;
a distal flange located at a distal end of the catheter body and extending radially outward from the exterior surface of the
catheter body;

a retaining structure located proximally from the distal flange and extending radially outward from the exterior surface of
the catheter body,

wherein a receptacle is formed between the distal flange and the retaining structure;
a restraining sheath movably coupled to the distal end of the catheter body, the restraining sheath having a distal end with
a tapered tip; and

an expandable heart valve having a proximal end and a distal end, collapsed into the restraining sheath and coupled to the
retaining structure of the delivery catheter at the distal end of the expandable heart valve,

wherein the restraining sheath is configured to move relative to the catheter body between a proximal closed position that
restrains the expandable heart valve and a distal exposed position that first exposes the proximal end of the expandable heart
valve,

wherein the retaining structure is configured to restrict proximal longitudinal displacement of the expandable heart valve
as the restraining sheath moves between the proximal closed position and the distal exposed position, and

wherein the distal flange is configured to restrict distal longitudinal displacement of the expandable heart valve;
positioning the expandable heart valve across the cardiac valve;
expanding the proximal end of the expandable heart valve against valve leaflets of the cardiac valve; and
expanding the distal end of the expandable heart valve after expanding the proximal end of the expandable heart valve.

US Pat. No. 9,101,467

VALVE PROSTHESIS

Medtronic Cv Luxembourg S...

1. A valve prosthesis comprising:
a valve body; and
a self-expanding frame,
wherein the valve body includes a first leaflet, a second leaflet, and a third leaflet, wherein the second leaflet extends
between the first leaflet and the third leaflet such that the first and third leaflets are separated from each other by the
second leaflet and wherein the first and second leaflets are sewn together to form a first commissure point and a second commissure
point, and the second and third leaflets are sewn together to form a third commissure point and a fourth commissure point,
and wherein the four commissure points are sewn to the frame.

US Pat. No. 9,060,891

IMPLANTABLE TEMPORARY FLOW RESTRICTOR DEVICE

Medtronic Vascular, Inc.,...

1. A medical device for gradually restoring blood flow through a body vessel, the device comprising:
a body portion of a flexible material having an inlet and an outlet, the body portion defining a lumen that extends between
the inlet and the outlet;

a support structure attached to the inlet of the body portion;
a self-expanding annular member attached to the outlet of the body portion; and
a plurality of linkages attached to the annular member that constrict a diameter of both the annular member and the outlet
of the body portion attached thereto, wherein the linkages are formed from a biostable material,

wherein when a force is applied to the plurality of linkages by the self-expanding annular member in vivo, the plurality of
biostable linkages are configured for elongation to allow gradual expansion of the annular member and the outlet of the body
portion attached thereto such that the body portion lumen transforms from an initial frustoconical shape for reducing blood
flow therethrough to a final cylindrical shape for allowing unimpeded blood flow therethrough.

US Pat. No. 9,554,904

DISTAL TIP ASSEMBLY FOR A HEART VALVE DELIVERY CATHETER

Medtronic CV Luxembourg S...

1. A catheter for implanting a prosthesis, comprising:
a retaining sleeve defining a hollow cavity for containing a prosthesis, the retaining sleeve comprising an outer diameter
and a distal edge; and

a distal tip assembly disposed distal of the retaining sleeve and configured to move axially relative to the retaining sleeve,
the distal tip assembly comprising,

a tip component having a tapered distal portion and an interior portion extending proximally from the distal portion, wherein
a proximal end of the tapered distal portion radially extends from the interior portion, and

a separate balloon element attached to the tip component and disposed proximal of the tapered distal portion, wherein the
balloon element forms a seal with the proximal end of the distal portion of the tip component and a proximal end of the interior
portion of the tip component, the balloon element being configured to move between a contracted position comprising a first
outer diameter to an expanded position comprising a second outer diameter, the second outer diameter being larger than the
outer diameter of the retaining sleeve,

wherein the first outer diameter of the balloon element in the contracted position is constant along the entire length of
the balloon element and substantially equal to the outer diameter of the retaining sleeve,

wherein the retaining sleeve is configured to move relative to the distal tip assembly from a closed configuration in which
the retaining sleeve abuts against the balloon element of the distal tip assembly and contains the prosthesis to an open configuration
in which the retaining sleeve separates from the balloon element of the distal tip assembly for releasing the prosthesis from
the catheter,

wherein when the retaining sleeve is in the closed configuration, the balloon element of the distal tip assembly in each of
the contracted position and the expanded position contacts the distal edge of the retaining sleeve.

US Pat. No. 9,555,223

METHOD AND APPARATUS FOR INFLATING AND DEFLATING BALLOON CATHETERS

Medtronic CryoCath LP, T...

9. A medical system, comprising:
a first fluid flow path directing fluid from a reservoir to a medical device inlet connector, the first fluid flow path including
a subcooler;

a second fluid flow path directing fluid from the reservoir to the medical device inlet connector that bypasses the subcooler;
and

a fluid return path between the medical device connector and a vacuum source, the fluid return path not overlapping with the
first or second fluid flow paths.

US Pat. No. 9,265,589

SYSTEM AND METHOD FOR NAVIGATED DRILL GUIDE

Medtronic Navigation, Inc...

1. A system comprising:
a guide instrument that has a first proximal end, a first distal end and defines a first bore, the guide instrument positionable
with a handle adjacent to an anatomy;

a sleeve having a second proximal end, a second distal end and a second bore, the sleeve slideably received within the first
bore;

a drill bit slideably received within the second bore and moveable relative to the sleeve, having a third distal end and an
axially extending body composed of a first non-ferrous metal material, the body including at least two distinct segments that
are axially separated, wherein the at least two distinct segments composed of a second non-ferrous metal material, the first
non-ferrous metal material having a first magnetic permeability different from a second magnetic permeability of the second
non-ferrous metal material and the at least two distinct segments include a segment length less than a total length of the
body;

at least one tracking device fixedly coupled about the sleeve; and
a controller configured to receive a varying signal from the at least one tracking device based at least on the first magnetic
permeability different from the second magnetic permeability;

wherein when the sleeve is in a first position, the at least one tracking device indicates a position of the first distal
end of the guide instrument, and when the sleeve is in a second position, the at least one tracking device indicates a position
of the third distal end of the drill bit;

wherein movement of the drill bit relative to and within the second bore of the sleeve and relative to the at least one tracking
device acts to change a current induced in the at least one tracking device due to movement of a first distinct segment and
a second distinct segment of the at least two distinct segments through the at least one tracking device and to determine
a depth of the third distal end;

wherein the controller receives the varying signal based on the current induced in the at least one tracking device to at
least assist in determining at least one of a position or a trajectory of the drill bit.

US Pat. No. 9,186,517

IDENTIFYING COMBINATIONS OF ELECTRODES FOR NEUROSTIMULATION THERAPY

Medtronic, Inc., Minneap...

1. A method comprising:
executing, by a processor, a search algorithm to control an implantable medical device to test combinations of electrodes
from an electrode set in an order that is determined based on proximity of the electrodes of the combinations to a longitudinally
central position within the set; and

storing, by the processor, information identifying at least one of the tested combinations as part of a neurostimulation therapy
program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

US Pat. No. 9,125,661

METHODS AND APPARATUS FOR RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method of performing renal neuromodulation, the method comprising:
passing a catheter comprising a single electrode through vasculature of a human patient to a renal blood vessel and proximate
to neural fibers that innervate a kidney of the patient; and

delivering radio frequency (RF) energy to the neural fibers via the electrode, wherein the RF energy ablates the neural fibers
to reduce renal sympathetic nerve activity of the patient,

wherein ablating the neural fibers that innervate the kidney of the patient results in a therapeutically beneficial reduction
in blood pressure of the patient.

US Pat. No. 9,463,066

METHODS FOR RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for renal neuromodulation, the method comprising:
positioning a spiral element of a catheter at an extra-arterial location within a human patient and adjacent to neural fibers
innervating a kidney of the patient;

transforming the spiral element from a low-profile delivery configuration to an expanded treatment configuration,
wherein, in the treatment configuration, the spiral element is sized and shaped to place a plurality of individual, discrete
electrodes arranged thereabout in apposition with target tissue at or near the neural fibers; and

ablating the neural fibers innervating the kidney via radio frequency (RF) energy from the electrodes, wherein ablating the
neural fibers innervating the kidney results in a therapeutically beneficial reduction in blood pressure in the patient.

US Pat. No. 9,179,984

MULTI-CONFIGURATION TRACKING ARRAY AND RELATED METHOD

Medtronic Navigation, Inc...

1. A method of performing a procedure with a first instrument so that a configuration of the first instrument is included
in a view produced from a surgical navigation process used to perform the procedure, the method comprising:
detecting a location in a first configuration relative to each other of at least a first tracking emitter with a medical instrument
holder and at least three second tracking emitters defining a plane with a tracking device holder;

changing a pattern of said first and second tracking emitters;
detecting said changed pattern of said first and second tracking emitters; and
relating said changed pattern of said first and second tracking emitters with a change between a first instrument configuration
and a second instrument configuration, wherein changing a pattern of said first and second tracking emitters includes switching
a first signal module between a first condition and a second condition and wherein said change between said first condition
and said second condition comprises:

emitting light and not emitting light from at least one of said first and second tracking emitters while maintaining the first
configuration relative to each other.

US Pat. No. 9,138,281

METHODS FOR BILATERAL RENAL NEUROMODULATION VIA CATHETER APPARATUSES HAVING EXPANDABLE BASKETS

Medtronic Ardian Luxembou...

1. A method for catheter-based renal neuromodulation of a human patient with a diagnosed condition comprising at least one
of heart failure, hypertension, acute myocardial infarction, impaired renal function or chronic renal failure, the method
comprising:
positioning a first catheter having a first therapeutic element in a low profile delivery configuration within a first renal
blood vessel of the patient and proximate to neural fibers innervating a first kidney of the patient,

wherein the first therapeutic element comprises a first expandable basket sized and shaped for the first renal blood vessel,
and wherein the first expandable basket comprises a plurality of first electrodes arranged thereon,

transforming the first therapeutic element from the delivery configuration to a treatment configuration such that the first
electrodes on the first expandable basket are in contact with an inner wall of the first renal blood vessel;

inhibiting neural communication along the neural fibers innervating the first kidney via radio frequency (RF) energy from
the first electrodes;

positioning a second catheter having a second therapeutic element in a low profile delivery configuration within a second
renal blood vessel of the patient and proximate to neural fibers innervating a second kidney of the patient,

wherein the second therapeutic element comprises a second expandable basket sized and shaped for the second renal blood vessel,
and wherein the second basket comprises a plurality of second electrodes arranged thereon;

transforming the second therapeutic element from the delivery configuration to a treatment configuration such that the plurality
of second electrodes on the second expandable basket are in contact with an inner wall of the second renal blood vessel; and

inhibiting neural communication along the neural fibers innervating the second kidney via RF energy from the second electrodes
wherein inhibiting neural communication along the neural fibers innervating the first and second kidney significantly improves
a measureable physiological parameter corresponding to the diagnosed condition of the patient.

US Pat. No. 9,387,031

MESH-OVERLAYED ABLATION AND MAPPING DEVICE

Medtronic Ablation Fronti...

1. A medical system, comprising:
a catheter body,
an elongate body disposed in the catheter body;
an expandable element having a proximal portion coupled to the catheter body and a distal portion coupled to the elongate
body;

a mesh surrounding the expandable element, the mesh having:
a proximal portion coupled to the catheter body, the proximal portion being electrically insulated;
a distal portion coupled to the elongate body, the distal portion of the mesh being electrically conductive and defining a
distal face configured to be in contact with tissue and the entirety of the distal face configured to deliver ablation energy
to the tissue;

a first circumferential portion located between the proximal portion and the distal portion, the first circumferential portion
being electrically conductive; and

a second circumferential portion located between the first circumferential portion and the distal portion, the second circumferential
portion being electrically insulated; and

a coolant source in fluid communication with the expandable element.

US Pat. No. 9,238,125

INFLATION DEVICE FOR BALLOON SINUS DILATION

Medtronic Xomed, Inc., J...

1. An inflation device for selectively inflating a balloon of surgical instrument, the device comprising:
a syringe including a plunger slidably disposed within a barrel;
a connector for fluidly connecting an outlet of the syringe with a surgical instrument balloon to establish a closed inflation
system between the syringe and an interior of the balloon; and

a mechanical pressure indicator associated with the syringe and configured to transition from a non-alert state to an alert
state when a pressure of the inflation system has reached a predetermined level.

US Pat. No. 9,179,974

HELICAL PUSH WIRE ELECTRODE

Medtronic Ardian Luxembou...

1. A catheter comprising:
an elongate shaft having proximal and distal ends and a lumen extending proximally therethrough from an exit point at the
distal end;

a support structure extending distally a fixed distance from the shaft distal end, the shaft being configured to deliver the
support structure to a treatment site within a vessel of a human patient; and

a wire electrode slidably disposed within the shaft lumen and having a helical portion extending through the exit point and
wrapped around the support structure to terminate in a fixed attachment at a distal end of the support structure, the helical
portion being configured to modulate one or more nerves within tissue at or otherwise proximate to a wall of the vessel;

wherein the wire electrode is adapted to be pushed distally through the exit point to cause radial expansion of the helical
portion about the support structure, and the wire electrode is further adapted to be withdrawn proximally through the exit
point to cause radial collapse of the helical portion about the support structure.

US Pat. No. 9,072,527

APPARATUSES AND METHODS FOR RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for renal neuromodulation, the method comprising:
extravascularly positioning a distal tip of a probe in an annular space between renal fascia and renal vasculature of a human
patient and in proximity to renal nerves along the renal vasculature of the patient;

delivering a catheter through the probe to a treatment location proximate the renal nerves, wherein the catheter comprises
an anchoring mechanism having—

a first collar;
a second collar located distally relative to the first collar;
an expandable member connected to the first and second collars,
wherein the expandable member is transformable between a collapsed configuration and an expanded configuration; and
a plurality of electrodes at the expandable member; and
delivering an electric field to the renal nerves via the electrodes to at least partially inhibit neural signaling along the
renal nerves.

US Pat. No. 9,421,601

METHODS FOR FORMING AN ORTHOGONAL END ON A HELICAL STENT

Medtronic Vascular, Inc.,...

1. A method of manufacturing a stent, the method comprising:
forming a wave form having a plurality of struts and a plurality of crowns, each crown connecting two adjacent struts, the
wave form having a central portion and two end portions located on opposite sides the central portion, some of the struts
located in the end portions have lengths longer and/or shorter than an average length of all of the struts of the wave form;
and

wrapping the wave form about a longitudinal axis to define a plurality of turns so that an end turn is disposed at an angle
relative to the longitudinal axis, a second turn is at a first pitch angle that is less than the angle that the end turn is
disposed relative to the longitudinal axis, a third turn is at a second pitch angle that is less than the first pitch angle,
and a fourth turn is at a third pitch angle that is less than the second pitch angle.

US Pat. No. 9,192,763

IMPLANTABLE MEDICAL DEVICE PROVIDING ADAPTIVE NEUROSTIMULATION THERAPY

MEDTRONIC, INC., Minneap...

1. A method comprising:
obtaining, in an external programmer during application of neurostimulation therapy, information that relates to efficacy
of the neurostimulation therapy being delivered to the patient by an implanted neurostimulator;

adjusting, in a processor, one or more stimulation parameters associated with the neurostimulation therapy being applied to
the patient by applying a set of adaptive logic to the obtained information to formulate an adjustment of a stimulation parameter;

submitting the adjusted parameters for approval by a clinician;
if approval is received, then inputting the adjusted parameters from the programmer to the implanted neurostimulator, and
otherwise stopping without inputting the adjusted parameters to the implanted neurostimulator.

US Pat. No. 9,579,020

ADHERENT CARDIAC MONITOR WITH ADVANCED SENSING CAPABILITIES

Medtronic Monitoring, Inc...

1. A system for monitoring a patient, the system comprising:
a first adherent device adapted to be adhered to a skin of a patient, the first adherent device having a first support with
a first adhesive configured to adhere the first support to the skin, the first adherent device including first electrodes
supported with the first support to couple to the skin of the patient, the first adherent device adapted to measure physiological
parameters of the patient with the first electrodes when coupled to the skin of the patient during a first monitoring period,
the first electrodes defining a first electrode axis;

a second adherent device adapted to be adhered to the skin of the patient, the second adherent device having a second support
with a second adhesive configured to adhere the second support to the skin, the second adherent device including second electrodes
supported with the second support to couple to the skin of the patient, the second adherent device adapted to measure physiological
parameters of the patient with the second electrodes when coupled to the skin of the patient during a second monitoring period
subsequent the first monitoring period, the second electrodes define a second electrode axis;

at least one accelerometer couplable to at least one of the first adherent device or the second adherent device and having
a measurement axis aligned with the respective electrode axis, wherein the at least one accelerometer is adapted to determine
an orientation of the respective electrode axis of the first electrodes or the second electrodes relative a reference axis
of the patient when coupled to the first or second adherent device during the respective monitoring periods; and

a processor system comprising a tangible medium configured to modify the measured physiological parameters based on the determined
orientations of the first electrode axis or the second electrode axis such that errors in the physiological parameter measurements
associated with changes in the orientation of the first and second adherent devices are reduced.

US Pat. No. 9,168,102

METHOD AND APPARATUS FOR PROVIDING A CONTAINER TO A STERILE ENVIRONMENT

Medtronic Navigation, Inc...

1. A system for delivering an item to a sterile field by a user, comprising:
a container having an open end and a closed end, wherein the container is configured to contain the item;
a closure system configured to close the open end of the container to an ambient environment, wherein the closure system includes
a deformable member, at least a portion of the open end of the container can be wrapped about the deformable member, and the
deformable member is configured to be crimped to a selected position to maintain the position of at least a portion of the
open end of the container;

the container including an exterior wall to define an internal portion where the item is operable to be positioned within
the internal portion;

wherein the container is configured to receive the item through the open end during an operative procedure to move the item
into a sterile field without sterilizing the item;

a passage system comprising a sleeve including a first open end, a second open end, and a wall extending between the first
open end and the second open end, the sleeve provided within the container and configured to be pulled partially out of the
container at a first time;

wherein the sleeve having the first open end, the second open end, and the wall extending between the first open end and the
second open end is removable from the container at a second time that is later than the first time when then sleeve is pulled
partially out of the container; and

a handle in addition to the closure system, wherein the handle has a flap that is connected near the closure system and extends
away from the closure system towards the closed end of the container to define a volume between the exterior wall of the container
and the flap and configured to be grasped by the user and protect the user from contacting the item when the item is positioned
within the container, the handle comprising a part of the container.

US Pat. No. 9,125,566

MULTI-SENSOR PATIENT MONITOR TO DETECT IMPENDING CARDIAC DECOMPENSATION

MEDTRONIC MONITORING, INC...

12. A system to predict an impending acute cardiac decompensation of a patient having heart failure, the system comprising:
an adherent device including at least four electrodes capable of electrically coupling to the patient;
impedance circuitry coupled to two or more of the at least four electrodes to measure an impedance value related to a hydration
value of the patient, and a respiration signal;

electrocardiogram circuitry coupled to two or more of the at least four electrodes to measure an electrocardiogram signal
associated with the patient; and

a processor system in communication with the impedance circuitry and the electrocardiogram circuitry, wherein the processor
system receives the measured hydration value, the respiration signal and the electrocardiogram signal and compares the received
signals with baseline values established for each, wherein the processor sets a flag indicating an impending acute cardiac
decompensation based on a combination of the compared values.

US Pat. No. 9,452,047

HEART VALVE PROSTHESIS RECAPTURE DEVICES

Medtronic Vascular Galway...

1. A heart valve prosthesis recapture device comprising:
a heart valve prosthesis having a radially compressed configuration and a radially expanded configuration;
a valve delivery capsule, having a distal end and a proximally facing opening, wherein the valve delivery capsule is configured
to maintain the heart valve prosthesis in the radially compressed configuration and wherein distal movement of the valve delivery
capsule releases at least a portion of the heart valve prosthesis from therewithin;

a guide wire disposed through the valve delivery capsule;
a recapture sleeve including a distal end fixedly attached to the guide wire at a location distal of the valve delivery capsule
and a proximal end having an opening along a longitudinal axis of the recapture sleeve,

wherein with the valve delivery capsule in a position such that the heart valve prosthesis is partially deployed proximal
of the valve delivery capsule, the recapture sleeve is configured to be moved proximally from the location distal from the
valve delivery capsule over the valve delivery capsule and over the partially deployed heart valve prosthesis to collapse
the partially deployed heart valve prosthesis.

US Pat. No. 9,186,089

INJECTABLE PHYSIOLOGICAL MONITORING SYSTEM

MEDTRONIC MONITORING, INC...

1. A monitoring system comprising:
one or more injectable detecting systems having a plurality of sensors that provide an indication of at least one physiological
event of a patient, the sensors arranged along a body that is configured for subcutaneous insertion just below the skin of
the patient by gun or syringe injection, wherein at least one of the plurality of sensors is configured to measure tissue
hydration; and

an injection device that includes:
a magazine capable of retaining a plurality of injectable detecting systems, and including a needle portion having a distal
end placed against a patient's tissue;

a pusher configured to engage one of the injectable detecting systems within the magazine; and
a handle pulled proximally to distally advance the pusher to inject the injectable detecting system out of the distal end
of the needle portion and into the patient's tissue.