1. A catheter system comprising:a prosthetic heart valve comprising a heart valve prosthesis attached to a support, wherein the support extends from a first end to a second end, and the second end of the support comprises retaining elements; and
a catheter for transvascular delivery of the prosthetic heart valve, the catheter comprising:
a guide system comprising a cartridge that includes a tip, an outer sleeve, and an inner sleeve, wherein the outer sleeve and the inner sleeve are configured to retain the prosthetic heart valve in a collapsed state radially therebetween, the inner sleeve including anchoring elements for engaging the retaining elements of the prosthetic heart valve, and wherein the outer sleeve and the inner sleeve are movable relative to each other along a longitudinal axis of the guide system for uncovering the prosthetic heart valve; and
a manipulating part coupled to the guide system for controlling movement of the guide system, the manipulating part comprising:
a tube comprising outer threads;
a first actuator coupled to the handle, wherein a first movement of the manipulating part, including rotation of the first actuator relative to the handle, causes relative axial movement between the outer sleeve and the inner sleeve to uncover the prosthetic heart valve; and
a second actuator coupled to the handle, wherein a second movement of the manipulating part, including movement of the second actuator in a proximal-distal direction of the catheter, causes relative movement between the tip and the outer sleeve.