US Pat. No. 9,295,551

METHODS OF IMPLANTING AN ENDOPROSTHESIS

JenaValve Technology GmbH...

1. A method of implanting an endoprosthesis including a plurality of positioning arches, a plurality of retaining arches,
and a plurality of retaining elements, the method comprising:
positioning the endoprosthesis relative to a native valve;
manipulating a handle of a catheter to move a first sleeve with respect to a stent holder in a first direction toward the
handle to uncover the plurality of positioning arches while covering the plurality of retaining elements with the first sleeve,
wherein manipulating the handle includes rotating a portion of the handle to move a first tubular member coupled to the first
sleeve in the first direction;

positioning the positioning arches within pockets of the native valve; and
manipulating the handle to move a second sleeve with respect to the stent holder in a second direction away from the handle
to uncover the plurality of retaining arches, wherein manipulating the handle includes moving a second tubular member coupled
to the second sleeve in the second direction;

wherein the stent holder is fixed relative to the handle via a third tubular element extending from the stent holder to the
handle, the third tubular element being radially inward of the first tubular element and radially outward of the second tubular
element.

US Pat. No. 9,044,320

DEVICE FOR THE IMPLANTATION AND FIXATION OF PROSTHETIC VALVES

JenaValve Technology GmbH...

1. A valve prosthesis, comprising:
a self-expandable outer stent component including exactly three struts configured for placement between each of three respective
portions of a native aortic valve and an aorta wall upon implantation of the valve prosthesis relative to the native aortic
valve;

a self-expandable inner stent component coupled to the self-expandable outer stent component at a distal end of the outer
stent component configured to be positioned farther from a native heart than a proximal end of the outer stent component,
at least a portion of the inner stent component being radially inward of the struts, the valve prosthesis configured to receive
the three portions of the native aortic valve between the respective three struts and the inner stent component upon implantation
of the valve prosthesis relative to the native aortic valve; and

a prosthetic valve component coupled to the self-expandable inner stent component.

US Pat. No. 9,949,824

DEVICES USEFUL FOR IMPLANTATION AT A HEART VALVE

JENAVALVE TECHNOLOGY, INC...

1. A prosthesis for implantation at a native semilunar valve site of a subject, the valve site having three semilunar sinuses and three native commissures, the prosthesis comprising:a valve prosthesis support structure comprising:
a carrier structure configured to carry prosthetic valve leaflets, and
exactly three engagement arms that meet one another at three respective junctures, wherein the engagement arms are shaped so as to define three peak complexes at the three respective junctures, and three trough complexes, each of which is between two of the peak complexes,
wherein in an implanted position of the prosthesis:
each of the engagement arms is configured to be at least partially disposed within a respective one of the semilunar sinuses, such that each of the peak complexes is disposed distal to a respective one of the native commissures, and each of the trough complexes is disposed at least partially within the respective one of the semilunar sinuses, and
the prosthesis is configured such that the native valve leaflets are configured to be positioned between the carrier structure and the engagement arms.

US Pat. No. 9,044,318

STENT FOR THE POSITIONING AND ANCHORING OF A VALVULAR PROSTHESIS

JenaValve Technology GmbH...

28. A stent configured to transition from a collapsed configuration when being introduced into a patient's body to an expanded
configuration when implanted, comprising:
three positioning arches configured to be positioned within respective pockets of a native valve on a radially-outward side
of a plurality of native valve leaflets of the native valve when the stent is in the expanded configuration;

three retaining arches, each retaining arch substantially circumferentially aligned with, and radially offset from, a corresponding
positioning arch, the retaining arches configured to be positioned on a radially-inward side of the plurality of native valve
leaflets, wherein at least one of the retaining arches includes at least one fastening portion comprising a plurality of holes
formed in an arm of the at least one of the retaining arches; and

a plurality of auxiliary arches, each auxiliary arch interspaced between two adjacent retaining arches.

US Pat. No. 9,889,002

DEVICES USEFUL FOR IMPLANTATION AT A HEART VALVE

JENAVALVE TECHNOLOGY, INC...

22. A device for implantation at a native heart valve, the device comprising:
an anchor element having a tubular configuration and defining a longitudinal direction and circumference;
a heart valve prosthesis disposed within the anchor element;
three elongate members attached to a lateral wall of the anchor element and positioned at equidistant angular intervals about
the circumference of the anchor element;

an impermeable casing disposed adjacent to the anchor element;
wherein the device is configured to be in a radially collapsed delivery configuration for endovascular delivery to the native
heart valve,

wherein the device is configured to be transitioned from the radially collapsed delivery configuration to a partially radially
expanded configuration, and then to a radially expanded implantation configuration, the partially radially expanded configuration
differing from the radially expanded implantation configuration,

wherein, in the radially expanded implantation configuration of the device:
the elongate members have a length extending in the longitudinal direction of the tubular anchor element, and
the impermeable casing is configured to be positioned to inhibit blood flow between the impermeable casing and heart tissue.

US Pat. No. 9,168,130

STENT FOR THE POSITIONING AND ANCHORING OF A VALVULAR PROSTHESIS IN AN IMPLANTATION SITE IN THE HEART OF A PATIENT

JENAVALVE TECHNOLOGY GMBH...

1. An expandable stent comprising a plurality of positioning arches configured to be positioned within a plurality of pockets
of a native valve on a first side of a plurality of native valve leaflets, a plurality of retaining arches configured to support
a valve prosthesis on a second side of the plurality of native valve leaflets opposite the first side, such that the plurality
of native valve leaflets are positioned radially inward of at least a portion of the positioning arches and radially outward
of at least a portion of the plurality of retaining arches when the expandable stent is implanted, and at least one radial
arch substantially circumferentially aligned with at least one of the positioning arches, the at least one radial arch having
a closed distal end positioned distally of the retaining arches;
wherein each retaining arch is associated and substantially circumferentially aligned with a corresponding positioning arch
and has a distal end portion adjacent and joined to a distal end portion of the corresponding positioning arch; and

wherein the valve prosthesis is attached to the plurality of retaining arches, such that at least a portion of the valve prosthesis
extends from the plurality of retaining arches transversely across an interior of the expandable stent.

US Pat. No. 9,445,896

METHODS FOR TREATING A HEART VALVE INSUFFICIENCY OR STENOSIS

JenaValve Technology, Inc...

1. A method of implanting an endoprosthesis including exactly three positioning arches, exactly three retaining arches, exactly
three connecting struts, a valve prosthesis directly attached to each of the exactly three retaining arches, and a plurality
of retaining elements, the method comprising:
positioning the endoprosthesis relative to a native valve;
manipulating a handle of a catheter to move a first sleeve element to uncover the positioning arches;
positioning the positioning arches within pockets of the native valve;
manipulating the handle to move a second sleeve element to uncover the retaining arches to allow the retaining arches and
the valve prosthesis to expand, wherein each of the exactly three retaining arches includes an apex axially aligned along
a longitudinal direction of the endoprostesis with a respective apex of one of the exactly three positioning arches;

clamping a plurality of native leaflets of the native valve between the positioning arches and the retaining arches; and
manipulating the handle to further move the first sleeve to uncover the plurality of retaining elements;
wherein each of the exactly three connecting struts connects two of the positioning arches at a first axial location along
the longitudinal direction and connects two of the retaining arches at a second axial location along the longitudinal direction,
different from the first axial location.

US Pat. No. 9,439,759

ENDOPROSTHESIS FOR IMPLANTATION IN THE HEART OF A PATIENT

JenaValve Technology, Inc...

1. An endoprosthesis comprising:
a plurality of first arches, each first arch including a pair of arms joined at a first apex, each arm including a plurality
of notches distributed along at least a portion of each arm;

a plurality of commissure regions connecting each first arch to an adjacent first arch; and
a heart valve prosthesis directly attached to the plurality of first arches.

US Pat. No. 9,138,315

MEDICAL DEVICE FOR TREATING A HEART VALVE INSUFFICIENCY OR STENOSIS

JENAVALVE TECHNOLOGY GMBH...

1. A catheter system comprising:
an endoprosthesis comprising:
a first portion including a plurality of retaining arches, each retaining arch including a first apex;
a second portion including a plurality of positioning arches, each positioning arch including a second apex axially aligned
with one of the first apices, the first apices and the second apices pointing in a same direction;

a third portion including a plurality of retaining elements; and
a heart valve prosthesis directly attached to the plurality of retaining arches; and
a catheter configured to releasably retain the endoprosthesis in a collapsed state and sequentially release the endoprosthesis
from the collapsed state to an expanded state, the catheter comprising:

a first housing portion for accommodating the first portion of the endoprosthesis;
a second housing portion for accommodating the second portion of the endoprosthesis;
a retaining mechanism defining a plurality of pockets formed therein for receiving the plurality of retaining elements of
the endoprosthesis; and

a handle configured to control movement of each of the first housing portion and the second housing portion with respect to
the handle;

wherein the first housing portion and the second housing portion are arranged relative to one another such that movement of
the second housing portion in a first direction relative to the endoprosthesis, before movement of the first housing portion
relative to the endoprosthesis, uncovers the second portion of the endoprosthesis from the catheter while the first portion
of the endoprosthesis is accommodated within the first housing portion and the plurality of retaining elements of the endoprosthesis
remains engaged with the plurality of pockets of the retaining mechanism and accommodated within the second housing portion;

wherein the second housing portion is further movable in the first direction to uncover and release the plurality of retaining
elements of the endoprosthesis from the retaining mechanism; and

wherein the handle includes:
a first slidable element movable with respect to a remainder of the handle along a fixed axial stroke length between first
and second limits; and

a second slidable element movable with respect to a remainder of the handle along a fixed axial stroke length between third
and fourth limits;

wherein each of the first and second limits has a different axial position than an axial position of the third limit.

US Pat. No. 9,339,386

MEDICAL DEVICE FOR TREATING A HEART VALVE INSUFFICENCY

JenaValve Technology, Inc...

1. A method of treating a native heart valve, the method comprising:
expanding a plurality of first arches from a collapsed configuration to an expanded configuration while holding a plurality
of second arches in a collapsed configuration, each first arch being directly connected to an adjacent first arch;

positioning the expanded plurality of first arches radially outward of at least one native leaflet of the native heart valve
and radially inward of a vessel wall;

after positioning the expanded plurality of first arches, expanding the plurality of second arches from the collapsed configuration
to an expanded configuration, the plurality of second arches being coupled to a prosthetic valve; and

engaging the at least one native leaflet with at least one first arch of the plurality of first arches and at least one second
arch of the plurality of second arches;

wherein the prosthetic valve is not attached to the plurality of first arches.

US Pat. No. 9,265,631

STENT FOR THE POSITIONING AND ANCHORING OF A VALVULAR PROSTHESIS IN AN IMPLANTATION SITE IN THE HEART OF A PATIENT

JenaValve Technology, Inc...

1. A stent, comprising:
a lattice skirt, having a plurality of closed cells extending around a circumference of the stent and disposed at a first
end of the stent;

a plurality of first arches, each having an apex projecting toward the first end of the stent and configured to be disposed
within a sinus pocket of a native valve radially outward of a plurality of leaflets of the native valve when the stent is
implanted;

a first set of retaining arms, wherein respective first ends of each of the retaining arms of the first set are joined to
the lattice skirt, and wherein respective second ends of each of the retaining arms of the first set are joined to one another;

a second set of retaining arms, wherein respective first ends of each of the retaining arms of the second set are joined to
the lattice skirt, and wherein respective second ends of each of the retaining arms of the second set are joined to one another;

a first pair of struts, wherein respective first ends of each of the struts of the first pair are joined to the lattice skirt,
and wherein respective second ends of each of the struts of the first pair of struts are joined to a portion of a retaining
arm of the first set of retaining arms between the first and second ends of the respective retaining arm; and

a second pair of struts, wherein respective first ends of each of the struts of the second pair are joined to the lattice
skirt, and wherein respective second ends of each of the struts of the second pair of struts are joined to a portion of a
retaining arm of the second set of retaining arms between the first and second ends of the respective retaining arm.

US Pat. No. 9,402,717

DEVICE FOR THE IMPLANTATION AND FIXATION OF PROSTHETIC VALVES

JenaValve Technology, Inc...

1. A method of treating a native aortic valve, the method comprising:
positioning an expandable outer stent component adjacent the native aortic valve, the outer stent component including exactly
three struts each having an apex pointing in a proximal direction towards a native heart;

expanding the exactly three struts of the outer stent component;
after expanding the exactly three struts, positioning each strut between a wall of an aorta and one of three respective portions
of the native aortic valve, wherein the exactly three struts align the outer stent component with the native aortic valve
in an axial direction;

positioning an expandable inner stent component radially inward of the portions of the native aortic valve and of the outer
stent component, wherein the inner stent component includes a prosthetic heart valve; and

expanding the inner stent component to press the portions of the native aortic valve radially outward toward the outer stent
component, such that the portions of the native aortic valve are positioned between the outer stent component and the inner
stent component.

US Pat. No. 9,510,947

CATHETER SYSTEM FOR INTRODUCING AN EXPANDABLE HEART VALVE STENT INTO THE BODY OF A PATIENT

JenaValve Technology, Inc...

1. A catheter system for introducing a heart valve stent into a body of a patient, the catheter system comprising:
a catheter tip comprising a first sleeve-shaped member, a second sleeve-shaped member, and a stent holder, wherein the first
and second sleeve-shaped members are moveable relative to each other and relative to the stent holder;

a handle; and
a catheter shaft extending between the catheter tip and the handle, the catheter shaft comprising:
a first tubular member having a distal end section connected to the first sleeve-shaped member and a proximal end section
connected to the handle; and

a second tubular member having a distal end section connected to the second sleeve-shaped member and a proximal end section
connected to the handle,

wherein the stent holder comprises a cylindrical body and a guiding element at least partly accommodated in the cylindrical
body, the guiding element forming an end section of the stent holder, and wherein the guiding element is movable relative
to the cylindrical body in a longitudinal direction of the stent holder.

US Pat. No. 9,597,182

CATHETER SYSTEM FOR INTRODUCING AN EXPANDABLE STENT INTO THE BODY OF A PATIENT

JenaValve Technology Inc....

1. A system for introducing an expandable stent into the body of a patient, comprising:
an end portion for accommodating the stent in a collapsed state, the end portion including a holder for releasably fixing
the stent, a first sleeve, and a second sleeve, wherein the first and second sleeves have an equal outer cross-section diameter
and are moveable relative to each other and relative to the holder, the first sleeve at least partially surrounding the holder;

a handle including a first operating part and a second operating part; and
a shaft including a first elongate member, a second elongate member, and a guiding tube having an outer cross-section diameter
less than the outer-cross section diameter of the first and second sleeves, wherein the first elongate member and the second
elongate member are at least partly receivable within the guiding tube;

wherein the first elongate member is coupled to the first sleeve and to the first operating part, and the second elongate
member is coupled to the second sleeve and to the second operating part;

wherein the guiding tube is releasable from the handle independent of release of the first elongate member and the second
elongate member from the handle; and

wherein a distal end of the guiding tube is tapered and abuts the first elongate member.

US Pat. No. 9,775,705

METHODS OF IMPLANTING AN ENDOPROSTHESIS

JenaValve Technology, Inc...

1. A method of implanting an endoprosthesis with a catheter system, the system including a cartridge at a proximal end of
the system, the cartridge including an inner sleeve, an outer sleeve, and a part, the method comprising:
positioning the endoprosthesis relative to a heart valve, wherein the endoprosthesis is in a collapsed form;
rotating a first actuator to cause relative movement between the outer sleeve and the part of the cartridge to expand a first
portion of the endoprosthesis while maintaining a second portion in the collapsed form, the second portion having eyes defining
holes that engage anchoring elements of the catheter system to anchor the endoprosthesis to the catheter system; and

actuating a second actuator to permit relative axial movement between the outer sleeve and the inner sleeve, expansion of
the second portion, and release of the endoprosthesis from the catheter system such that the endoprosthesis is in an expanded
form.

US Pat. No. 9,707,075

ENDOPROSTHESIS FOR IMPLANTATION IN THE HEART OF A PATIENT

JENAVALVE TECHNOLOGY, INC...

1. An endoprosthesis, comprising:
a stent comprising:
an annular skirt portion comprising a plurality of closed cells extending around a circumference of the stent and disposed
at a first end of the stent;

a plurality of first arches each having an apex pointing toward the first end of the stent, the plurality of first arches
configured to be disposed within sinus pockets of a native valve radially outward of leaflets of the native valve;

a plurality of arms each having a first end joined to a first end of an adjacent arm and a second end joined to the annular
skirt portion, each first arch being positioned between two arms of the plurality of arms, and the plurality of arms being
configured to be disposed radially inward of the leaflets of the native valve; and

a plurality of second arches each having an apex pointing toward a second end of the stent, each apex of a second arch of
the plurality of arches being axially aligned, along a longitudinal direction of the stent, with an apex of a corresponding
first arch of the plurality of first arches; and

a heart valve prosthesis attached to the stent.

US Pat. No. 9,744,031

PROSTHETIC HEART VALVE AND ENDOPROSTHESIS COMPRISING A PROSTHETIC HEART VALVE AND A STENT

JENAVALVE TECHNOLOGY, INC...

1. An endoprosthesis comprising:
a stent; and
a prosthetic heart valve coupled to the stent, the prosthetic heart valve comprising:
(a) a tissue assembly comprising at least two separate, monolithic pieces coupled together, each piece comprising a natural
tissue material or a synthetic material, wherein each piece includes:

(i) two sleeves each having a free end;
(ii) a leaflet having a first opened position for opening the heart chamber and a second closed position for closing the heart
chamber, the leaflet being between the two sleeves and able to move between the first and second positions in response to
a blood flow through the heart;

(iii) a skirt portion proximal to the leaflet and the sleeves, wherein the skirt portion mounts the prosthetic heart valve
to the stent; and

(iv) a bendable transition area forming a junction between the leaflet and the skirt portion, the bendable transition area
being essentially U-shaped; and

(b) at least one reinforcement element coupled to the tissue assembly and attached to a commissure portion of the stent;
wherein the at least one reinforcement element is attached to two adjacent monolithic pieces of the tissue assembly along
the free end of a sleeve of each adjacent monolithic piece, and wherein the at least one reinforcement element covers an entire
outermost surface of the sleeves to prevent the sleeves from contacting the commissure portion of the stent; and

wherein a proximal-most end of the prosthetic heart valve has a zigzag shape.

US Pat. No. 9,918,835

MEDICAL DEVICE FOR TREATING A HEART VALVE INSUFFICENCY

JenaValve Technology, Inc...

1. An endoprosthesis comprising:
a plurality of first arches configured to be respectively positioned within a plurality of pockets of a native heart valve
on a first side of a plurality of native valve leaflets, each first arch having an apex oriented in a first direction and
an open end joined to an open end of an adjacent first arch;

a plurality of second arches each having an apex oriented in the first direction and configured to be positioned on a second
side of the plurality of native valve leaflets, such that the plurality of native valve leaflets are positioned radially inward
of at least a portion of the plurality of first arches and radially outward of at least a portion of the plurality of second
arches when the endoprosthesis is implanted; and

a prosthetic valve attached to the plurality of second arches such that at least part of the prosthetic valve extends from
the plurality of second arches transversely across an interior of the endoprosthesis.

US Pat. No. 9,867,699

ENDOPROSTHESIS FOR IMPLANTATION IN THE HEART OF A PATIENT

JenaValve Technology, Inc...

1. An endoprosthesis comprising:
a plurality of first arches, each first arch having an apex pointing in a proximal direction;
a plurality of second arches, each second arch having an apex axially aligned, in a longitudinal direction of the endoprosthesis,
with an apex of a corresponding first arch;

a supporting structure located at a proximal-most end of the endoprosthesis, at least a portion of the supporting structure
being flared radially outward, wherein the supporting structure comprises at least one row of lattice cells, and a proximal-most
end of each lattice cell includes a notch; and

a heart valve prosthesis attached to the plurality of second arches.

US Pat. No. 9,867,694

RADIALLY COLLAPSIBLE FRAME FOR A PROSTHETIC VALVE AND METHOD FOR MANUFACTURING SUCH A FRAME

JenaValve Technology Inc....

1. A radially collapsible frame for a prosthetic valve, the frame comprising:
an outflow end region at a proximal end of the frame and an inflow end region at a distal end of the frame, opposite to the
outflow end region;

at least two radially spaced commissure attachment regions located at the outflow end region of the frame and being configured
to receive commissure edges of at least two prosthetic valve leaflets;

a plurality of circumferentially arranged retaining arches, each retaining arch including a first arm joined to a second arm
at a distal end of the retaining arch;

a cell structure comprising a plurality of lattice cells proximal to the distal end of each retaining arch, the plurality
of lattice cells comprising a plurality of first cells disposed between the first arm and the second arm of each retaining
arch, and a plurality of second cells disposed between adjacent arms of two neighboring retaining arches; and

at least one anchoring/positioning arch radially outward of at least a portion of the plurality of first cells of the cell
structure.

US Pat. No. 9,987,133

STENT FOR THE POSITIONING AND ANCHORING OF A VALVULAR PROSTHESIS IN AN IMPLANTATION SITE IN THE HEART OF A PATIENT

JenaValve Technology, Inc...

1. A stent for implantation at a native heart valve, the stent comprising:an expandable body having a first open end and second open end opposite the first open end, a longitudinal axis of the expandable body extending between the first open end and the second open end; and
a plurality of positioning arches positioned around an outer perimeter of the expandable body, each positioning arch terminating in an apex facing in a direction toward the first open end of the expandable body,
wherein the stent has an implanted configuration when in an implanted position at the native heart valve, the implanted configuration comprising:
the expandable body being in an expanded configuration and oriented such that the first open end is upstream the second open end relative to a direction of blood flow through the native heart valve,
the apex of each of the positioning arches being positioned within a respective one of a plurality of pockets of the native heart valve, the pockets being defined by the native leaflets and a heart structure from which the native leaflets extend, and
the first open end of the expandable body extending past each of the apexes of the positioning arches by a distance such that the first open end of the expandable body is positioned upstream of an annulus of the heart valve and out of contact with nerve bundles of the heart valve.

US Pat. No. 9,878,127

CATHETER DELIVERY SYSTEM FOR HEART VALVE PROSTHESIS

JenaValve Technology, Inc...

1. Operating handle for manipulating a catheter tip of a catheter delivery system, the operating handle comprising:
a hand grip designed to be held by a user; and
a manipulating part axially aligned with the hand grip, wherein the manipulating part is rotatable relative to the hand grip
about a longitudinal axis defined by the operating handle; and

a first sliding member and a second sliding member, each being operatively coupled to the manipulating part via a cam mechanism
that comprises:

a cylindrical member connected with the manipulating part, the cylindrical member comprising a first cam groove and a second
cam groove;

a first pin member having a first end portion connected with the first sliding member, and a second end portion opposite to
the first end portion, the second end portion of the first pin member engaging the first cam groove such that, upon rotation
of the manipulating part relative to the hand grip, the first pin member follows a cam profile defined by the first cam groove;

a second pin member having a first end portion connected with the second sliding member, and a second end portion opposite
to the first end portion, the second end portion of the second pin member engaging the second cam groove such that, upon rotation
of the manipulating part relative to the hand grip, the second pin member follows a cam profile defined by the second cam
groove;

wherein upon rotation of the manipulating part relative to the hand grip independently from each other, the first and second
sliding members are axially moved along the longitudinal axis.

US Pat. No. 9,877,828

STENT FOR THE POSITIONING AND ANCHORING OF A VALVULAR PROSTHESIS IN AN IMPLANTATION SITE IN THE HEART OF A PATIENT

JENAVALVE TECHNOLOGY, INC...

13. An expandable stent comprising:
a plurality of first arches;
a plurality of second arches, each second arch having an apex opposite an open end portion, the apex of each second arch being
axially aligned, in a longitudinal direction of the expandable stent, with an apex of a corresponding first arch, and the
open end portion of each second arch being joined to an open end portion of the corresponding first arch, wherein the apex
of each first arch and the apex of each second arch point in a proximal direction;

a plurality of third arches, each third arch corresponding to, and circumferentially interspaced between, two adjacent second
arches and having an apex pointing in the proximal direction; and

a valve prosthesis attached to each second arch;
wherein the stent is configured for implantation relative to a native valve comprising a plurality of native valve leaflets,
a proximal end of the stent being closer to a native heart than a distal end of the stent when the stent is implanted.

US Pat. No. 9,788,945

SYSTEMS FOR IMPLANTING AN ENDOPROSTHESIS

JENAVALVE TECHNOLOGY, INC...

1. A system comprising:
a prosthetic heart valve including a heart valve prosthesis attached to an anchoring support, wherein the anchoring support
includes (1) a first portion and (2) a second portion having eyes at an end of the anchoring support;

a guide system for transvascular delivery of the prosthetic heart valve, the guide system comprising:
a cartridge at a proximal end of the guide system, the cartridge including an outer sleeve, an inner sleeve, and a part, wherein
the inner sleeve has anchoring elements for engaging the eyes of the second portion of the anchoring support, and the outer
sleeve is arranged to cover the anchoring elements and the eyes when the prosthetic heart valve is in a collapsed state; and

a manipulating part at a distal end of the guide system, the manipulating part comprising:
a tube having outer threads;
a second actuator adjacent the tube and moveable in a proximal-to-distal direction to allow movement of the outer sleeve and
the inner sleeve relative to one another and thereby deploy at least the second portion of the prosthetic heart valve; and

a first actuator engaging the threads of the tube to rotate about a longitudinal axis of the tube to cause relative axial
movement between the outer sleeve and the part of the cartridge to deploy at least the first portion of the prosthetic heart
valve.

US Pat. No. 10,307,251

CATHETER SYSTEM FOR INTRODUCING AN EXPANDABLE STENT INTO THE BODY OF A PATIENT

Jenavalve Technology, Inc...

1. A method of implanting an endoprosthesis including three positioning arches, three retaining arches, a valve prosthesis directly attached to the three retaining arches, and a plurality of retaining elements, the method comprising:positioning the endoprosthesis relative a native heart valve;
manipulating a handle of a catheter to move a first sleeve with respect to a stent holder in a first direction toward the handle to uncover the positioning arches while covering the plurality of retaining elements within the first sleeve, wherein manipulating the handle moves a first tubular member coupled to the first sleeve in the first direction;
positioning the positioning arches within pockets of the native valve;
manipulating the handle to move a second sleeve with respect to the stent holder in a second direction opposite the first direction and away from the handle to uncover the retaining arches, wherein manipulating the handle moves a second tubular member coupled to the second sleeve in the second direction; and
securing a plurality of native leaflets of the native valve within the positioning arches and outside of the retaining arches;
wherein the stent holder is fixed relative to the handle via a holder tube extending proximally from the stent holder, the holder tube having a distal end connected to the holder and a proximal end connected to the handle, and wherein the holder tube is within the first tubular member, and
wherein the holder includes a holder support section distal to the holder, and an extension portion has a proximal end connected to the holder and a distal end connected to the holder support section.

US Pat. No. 10,433,954

RADIALLY COLLAPSIBLE FRAME FOR A PROSTHETIC VALVE AND METHOD FOR MANUFACTURING SUCH A FRAME

JenaValve Technology, Inc...

1. A method for treating a native heart valve, the method comprising:positioning a stent within a native heart valve, the stent including a frame and prosthetic valve leaflets, wherein the frame includes
at least two commissure attachment regions located at a proximal outflow end of the frame, wherein each commissure attachment region is attached to commissure edges of the prosthetic valve leaflets,
a plurality of circumferentially arranged retaining arches attached to cusp edges of the prosthetic valve leaflets, each retaining arch including a first arm joined to a second arm at an apex pointing towards a distal inflow end of the frame,
a cell structure comprising a first plurality of cells disposed between the first arm and the second arm of each retaining arch, and a second plurality of cells disposed between adjacent arms of two neighboring retaining arches, and
at least one arch radially outward of at least a portion of the cell structure;
wherein the stent is positioned within the native heart valve so that the first plurality of cells of the cell structure inhibit one or more leaflets of the native heart valve from contacting the prosthetic valve leaflets.

US Pat. No. 10,363,134

DEVICE FOR THE IMPLANTATION AND FIXATION OF PROSTHETIC VALVES

JenaValve Technology, Inc...

1. A method of treating a native aortic valve, the method comprising:positioning a first expandable stent component adjacent the native aortic valve, the first stent component including three struts, wherein the three struts include exactly one strut for placement between each leaflet of the native aortic valve and a wall of an aorta, wherein each strut includes an apex pointing in a proximal direction towards a native heart;
expanding the struts of the first stent component;
after expanding the struts, positioning each strut between the respective leaflet and the wall of the aorta, wherein the struts align the first stent component with the native aortic valve in an axial direction;
positioning a second expandable stent component radially inward of the leaflets of the native aortic valve and of the first stent component, wherein the second stent component includes a prosthetic heart valve; and
expanding the second stent component to press the leaflets of the native aortic valve radially outward toward the first stent component, such that the leaflets of the native aortic valve are positioned between the first stent component and the second stent component.