US Pat. No. 9,149,794

FORMYL GROUP-CONTAINING POROUS SUPPORT, ADSORBENT USING SAME, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING THE ADSORBENT

KANEKA CORPORATION, Osak...

1. A method for producing an affinity adsorbent, comprising the steps of
immobilizing an amino group-containing ligand on a formyl group-containing porous base matrix in two stages of imination and
reductive reaction; and

carrying out a stabilizing procedure after the imination and before adding a reducing agent for the reductive reaction,
wherein the imination is carried out in a reaction mixture having pH of not less than 11.5 and less than 13.0, and
the stabilizing procedure after the imination and before adding the reducing agent for the reductive reaction comprises adjusting
a pH of a reaction mixture within ±1 of the pH during the reductive reaction without adding the reducing agent.

US Pat. No. 9,166,176

POLYCYCLIC AROMATIC COMPOUND

Kyoto University, Kyoto ...

1. A polycyclic aromatic compound or a salt thereof represented by the following formula (I):
wherein
X represents B, P, P?O, P?S, P?Se, As, As?O, As?S, As?Se, Sb, Sb?O, Sb?S, Sb?Se, an optionally substituted metal in groups
3 to 11 in the periodic table, or an optionally substituted metal or metalloid in group 13 or 14 of the periodic table; and

ring A, ring B, ring C, and ring D are the same or different, and each represents an optionally substituted phenyl ring, an
optionally substituted phenyl ring fused to an aryl or heteroaryl ring, or an optionally substituted phenyl ring wherein a
carbon atom of two adjacent rings are bonded to form a pyrrole ring,

wherein the compound represented by formula (I) is not a fullerene or a heterofullerene.

US Pat. No. 9,296,950

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC Corporation, Tokyo (...

1. A liquid crystal composition that has a nematic phase, and contains at least one compound represented by formula (1) as
a first component, at least one compound represented by formula (2) as a second component, and at least one compound represented
by formula (3-4-2) as a third component; a ratio of the second component is in the range of more than 44% by weight or equal
to 44% by weight but less than 65% by weight or equal to 65% by weight based on the total weight of the liquid crystal composition:

wherein, R1 and R4 are independently alkyl having 1 to 12 carbons or alkenyl having 2 to 12 carbons, R2 and R3 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkenyl
having 2 to 12 carbons in which arbitrary hydrogen is replaced by fluorine; X1, X2 and X3 are independently hydrogen or fluorine; Y1 is fluorine, chlorine or trifluoromethoxy, and any one of R2 or R3 is independently alkenyl having 2 to 12 carbons, or alkenyl having 2 to 12 carbons in which arbitrary hydrogen is replaced
by fluorine.

US Pat. No. 9,181,483

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a nematic phase and contains at least one compound selected from the group of compounds
represented by formula (1) as a first component and at least one compound selected from the group of compounds represented
by formula (2) as a second component and:

wherein, in formula (1) and formula (2), R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons; R3 is alkenyl having 2 to 12 carbons, or alkenyl having 2 to 12 carbons in which at least of one of hydrogen is replaced by fluorine;
ring A is 1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 2,6-difluoro-1,4-phenylene, pyrimidine-2,5-diyl, 1,3-dioxane-2,5-diyl
or tetrahydropyran-2,5-diyl; Z1 is a single bond, ethylene, vinylene, methyleneoxy, carbonyloxy or difluoromethyleneoxy; X? and X2 are independently hydrogen or fluorine; and n is 1, 2, 3 or 4.

US Pat. No. 9,296,951

COMPOUND HAVING 3,3-DIFLUORO-1-PROPENYLOXY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in formula (1),
R1 is alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, at least one of —CH2CH2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by halogen;

ring A1 and ring A2 are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, 1,4-phenylene in which at least one of hydrogen is
replaced by halogen, tetrahydropyran-2,5-diyl, pyrimidine-2,5-diyl, pyridine-2,5-diyl, 1,3-dioxane-2,5-diyl or 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl;

Z1 and Z2 are independently a single bond or alkylene having 1 to 4 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O— or —COO—, at least one of —CH2CH2— may be replaced by —CH?CH— or —C?C—, and in the groups, at least one of hydrogen may be replaced by halogen;

L1 and L2 are independently hydrogen or halogen; and

a is 0, 1, 2 or 3.

US Pat. No. 9,193,907

LIQUID CRYSTAL COMPOUND HAVING VINYLOXY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1-1):

wherein, in formula (1-1),
R1 is hydrogen, alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons, alkoxyalkyl having 2 to 9 carbons, alkenyl having
2 to 10 carbons or alkenyloxy having 2 to 9 carbons;

R2 is alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons, alkoxyalkyl having 2 to 9 carbons, alkenyl having 3 to 10 carbons
or alkenyloxy having 2 to 9 of carbons;

ring A1 is 1,4-cyclohexylene, 1,4-cyclohexenylene or 1,4-phenylene;

ring A2 is 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, 2-fluoro-1,4-phenylene or 2,3-difluoro-1,4-phenylene;

Z1 and Z2 are independently a single bond, —(CH2)2—, —CH2O—, —OCH2—, —COO— or —OCO—;

L1 and L2 are independently fluorine or chlorine and at least one of L1 and L2 is fluorine; and

1 is 0, 1, or 2;
wherein when l is 0, R2 is alkoxy having 1 to 6 carbons, alkoxyalkyl having 2 to 6 carbons, or alkenyloxy having 2 to 5 carbons; and

wherein when l is 1 or 2, A2 is 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, or 2-fluoro-1,4-phenylene.

US Pat. No. 9,376,620

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy and contains at least one compound selected from
the group of compounds represented by formula (1) as a first component and at least one compound selected from the group of
compounds represented by formula (2) as a second component, wherein a ratio of the second component is in the range of 25%
by weight to 60% by weight based on the weight of the liquid crystal composition:
wherein, in formula (1) and formula (2), R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkenyloxy
having 2 to 12 carbons, or alkyl having 1 to 12 carbons in which at least one of hydrogen is replaced by fluorine or chlorine;
R3 is alkyl having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkyl having 1 to 12 carbons in which at least one of hydrogen
is replaced by fluorine or chlorine, or alkenyl having 2 to 12 carbons in which at least one of hydrogen is replaced by fluorine
or chlorine; R4 is alkenyl having 2 to 12 carbons, or alkenyl having 2 to 12 carbons in which at least one of hydrogen is replaced by fluorine
or chlorine; ring A and ring B are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, tetrahydropyran-2,5-diyl, 1,4-phenylene,
1,4-phenylene in which at least one of hydrogen is replaced by fluorine or chlorine, naphthalene-2,6-diyl, naphthalene-2,6-diyl
in which at least one of hydrogen is replaced by fluorine or chlorine, chroman-2,6-diyl, or chroman-2,6-diyl in which at least
one of hydrogen is replaced by fluorine or chlorine; Z1 and Z2 are independently a single bond, ethylene, carbonyloxy or methyleneoxy; a and b are independently 0, 1, 2 or 3; and a sum
of a and b is 3 or less.

US Pat. No. 9,860,981

TRANSPARENT CONDUCTIVE FILM AND METHOD FOR PRODUCING SAME

JNC CORPORATION, Tokyo (...

1. A transparent conductive film, consisting of:
a transparent base formed of a film-like polymer resin;
a first hard coat layer laminated on one face of the base;
a first transparent dielectric layer optionally laminated on a face of the first hard coat layer on a side opposite to the
base; and

a first transparent conductive layer laminated on a face of the first transparent dielectric layer on a side opposite to the
first hard coat layer, wherein

the base has a film thickness of 2 to 250 micrometers,
the first hard coat layer is formed of a hardening resin containing an inorganic oxide, and has a refractive index of 1.40
to 1.90 and a film thickness of 0.5 to 6 micrometers, wherein the hardening resin is an ultraviolet curing resin, and the
inorganic oxide comprises Al2O3, SnO2, ZrO2, TiO2, or a composite oxide thereof to adjust the refractive index of the hard coat layer,

the first transparent dielectric layer is formed of an inorganic substance, and has a refractive index of 1.30 to 1.50 and
a film thickness of 10 to 50 nanometers, and

the first transparent conductive layer is formed of at least one kind selected from a group of an inorganic oxide, a metal
and carbon, and subjected to patterning, and has a film thickness of 10 nanometers to 2 micrometers.

US Pat. No. 9,297,799

METHOD FOR MEASURING PROTOZOAN OOCYST AND DETECTING REAGENT

NATIONAL UNIVERSITY CORPO...

1. A method for measuring Cryptosporidium parvum oocysts in water, which comprises:
adding magnetic fine particles of 150 to 500 nm particle diameter, which have an antioocyst antibody for specifically recognizing
Cryptosporidium parvum oocysts immobilized thereto, to an aqueous analyte containing Cryptosporidium parvum oocysts to form complexes of the Cryptosporidium parvum oocysts with the magnetic fine particles through the antioocyst antibody, wherein the magnetic fine particles are magnetic
fine particles having stimuli-responsive upper critical solution temperature (UCST) polymers immobilized thereto;

recovering the thus formed Cryptosporidium parvum oocyst/antioocyst antibody/magnetic fine particle complexes by a magnetic separation; and

counting the number of Cryptosporidium parvum oocysts.

US Pat. No. 9,175,222

OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that exhibits an optically isotropic liquid crystal phase, contains an achiral component T
and a chiral agent, and contains at least one compound selected from the group of compounds represented by formula (1) as
a first component of the achiral component T:
wherein R1 is hydrogen or alkyl having 1 to 20 carbons, at least one —CH2— in the alkyl may be replaced by —O—, —S—, —COO— or —OCO—, at least one —CH2—CH2— in the alkyl may be replaced by —CH?CH—, —CF?CF— or —C?C—, and in the alkyl, in the group formed by replacing at least one
—CH2— in the alkyl by —O—, —S—, —COO— or —OCO—, or in the group formed by replacing at least one —CH2—CH2— in the alkyl by —CH?CH—, —CF?CF— or —C?C—, at least one hydrogen may be replaced by halogen, provided that in R1, —O— and —CH?CH— are not adjacent and —CO— and —CH?CH— are not adjacent; L1, L2, L3, L4, L5, L6, L7 and L8 are independently hydrogen or fluorine; Z1, Z2 and Z3 are each independently a single bond, —COO— or —CF2O—, but at least one thereof is —COO—; n1 and n2 are each independently 0 or 1; and X1 is hydrogen, halogen, —SF5 or alkyl having 1 to 10 carbons, at least one —CH2— in the alkyl may be replaced by —O—, —S—, —COO— or —OCO—, at least one —CH2—CH2— in the alkyl may be replaced by —CH?CH—, —CF?CF— or —C?C—, and in the alkyl, the group formed by replacing at least one
—CH2— in the alkyl by —O—, —S—, —COO— or —OCO—, or the group formed by replacing at least one —CH2—CH2— in the alkyl by —CH?CH—, —CF?CF— or —C?C—, at least one hydrogen may be replaced by fluorine, provided that in X1, —O— and —CH?CH— are not adjacent and —CO— and —CH?CH— are not adjacent.

US Pat. No. 9,273,245

COMPOUND HAVING 2,2-DIFLUOROVINYLOXY GROUP OR 1,2,2-TRIFLUOROVINYLOXY GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in the formula,
R1 is alkyl having 1 to 20 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, and at least one of —(CH2)2— may be replaced by —CH?CH—;

ring A1 is 1,4-phenylene in which hydrogen may be replaced by halogen, tetrahydropyran-2,5-diyl or 1,3-dioxane-2,5-diyl,

ring A3 is 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene in which hydrogen may be replaced by halogen, tetrahydropyran-2,5-diyl
or 1,3-dioxane-2,5-diyl,

ring A2 is 1,4-phenylene in which at least one hydrogen is replaced by halogen;

Z1 and Z3 are independently a single bond, —(CH2)2—, —CH?CH—, —CF2O—, —CH2O—, —CF?CF—, —(CH2)2CF2O—, —CH?CHCF2O, —CF2O(CH2)2—, CF2OCH?CH—, —CH?CH—(CH2)2— or —(CH2)2—CH?CH—;

Z2 is —CF2O—;

L1, L2 and L3 are independently hydrogen or halogen;

m is 1 or 2; and
n is 0, 1, or 2, and a sum of m and n is 1, 2 or 3, and when m or n is 2 or 3, a plurality of ring A1 or ring A3 may be identical or different, and a plurality of Z1 or Z3 may be identical or different.

US Pat. No. 9,151,739

COELENTERAZINE ANALOGS AND MANUFACTURING METHOD THEREOF

JNC CORPORATION, Tokyo (...

1. A process for producing a compound represented by general formula (1) below:

wherein R1, R2, R3, R4, R5, X1 and X2 are the same as defined below, which comprises reacting a compound represented by general formula (2) below:


wherein:
R4 is a substituted or unsubstituted benzyl;

R5 is (a) hydrogen or (b) a substituted or unsubstituted alkyl;

X1 is (a) hydrogen or (b) hydroxy; and

X2 is (a) hydrogen or (b) hydroxy;

with a compound represented by general formula (3) below:

wherein:
R1 is (a) hydrogen, (b) hydroxy, (c) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic
group, or (d) trifluoromethyl;

R2 is (a) hydrogen, (b) hydroxy, (c) a halogen, (d) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with
an alicyclic group, (e) trifluoromethyl or (f) an alkoxyl; and,

R3 is (a) hydrogen, (b) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic group, or (c)
an alkoxyl;

with the proviso that when R2 and R3 are hydrogen, R1 is (a) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic group, or (b) trifluoromethyl,

when R1 and R3 are hydrogen, R2 is (a) hydroxy, (b) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic group, (c) trifluoromethyl,
or (d) an alkoxyl, and,

when R1 and R2 are hydrogen, R3 is (a) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic group, or (b) an alkoxyl.

US Pat. No. 9,382,353

POLYMERIZABLE COMPOUND HAVING THIOESTER GROUP, POLYMERIZABLE COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
in formula (1),
P1 is —SCO-(M1)C?CH(M2), and P2 is —SCO-(M3)C?CH(M4), where M1, M2, M3 and M4 are independently hydrogen, fluorine, methyl or trifluoromethyl;

Sp1 and Sp2 are a single bond;

ring A1, ring A2, ring A3 and ring A4 are independently a divalent group derived from benzene, naphthalene, pyrimidine or pyridine, and in these divalent groups
at least one hydrogen may be replaced by halogen, alkyl having 1 to 12 carbons, alkyl having 1 to 12 carbons in which at least
one hydrogen has been replaced by halogen or -Sp3-P3, where the definition of P3 is the same as that of P1 or P2 and the definition of Sp3 is the same as that of Sp1 or Sp2, and ring A2 and ring A3 may be independently 1,4-cyclohexylene, 1,4-cyclohexenylene, tetrahydropyran-2,5-diyl or 1,3-dioxane-2,5-diyl;

Z1, Z2 and Z3 are independently a single bond or alkylene having 1 to 10 carbons, and in this alkylene at least one —CH2— may be replaced by —O—, —CO—, —COO— or —OCO—, and at least one —CH2—CH2— may be replaced by —CH?CH—, —C(CH3)?CH—, —CH?C(CH3)—, —C(CH3)?C(CH3)— or —C?C—, and in these groups at least one hydrogen may be replaced by fluorine or chlorine; and

a and b are independently 0 or 1.

US Pat. No. 9,347,003

LIQUID CRYSTAL COMPOUND HAVING TETRAFLUOROPROPENYL, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein in formula (1),
R1 is C1-15 alkyl, and in the alkyl, at least one —CH2— is optionally replaced by —O— or —S—, at least one —(CH2)2— is optionally replaced by —CH?CH—, and at least one hydrogen is optionally substituted with halogen;

ring A1, ring A2, ring A3, ring A4 and ring B1 are independently 1,4-cyclohexylene, 1,4-phenylene, 1,4-phenylene in which at least one hydrogen is substituted with halogen,
1,3-dioxane-2,5-diyl, tetrahydropyran-2,5-diyl, pyrimidine-2,5-diyl, or pyridine-2,5-diyl;

Z1, Z2, Z3 and Z4 are independently a single bond, —(CH2)2—, —CH?CH—, —C?C—, —COO—, —OCO—, —CF2O—, —OCF2—, —CH2O—, —OCH2—, or —CF?CF—; and

l, m, n and o are independently 0 or 1, and l+m+n+o?1.

US Pat. No. 9,346,767

SUBSTITUTED PYRAZINES AND A PROCESS FOR PRODUCING THE SAME

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (VIII):

wherein
R1 is hydrogen; a halogen; an aryl which may optionally be substituted with at least one substituent selected from the group
consisting of a halogen, hydroxy, an alkyl having 1 to 6 carbon atoms, an alkoxy having 1 to 6 carbon atoms, an amino and
a dialkylamino having 1 to 6 carbon atoms; an arylalkyl which may optionally be substituted with at least one substituent
selected from the group consisting of a halogen, hydroxy, an alkyl having 1 to 6 carbon atoms, an alkoxy having 1 to 6 carbon
atoms, an amino and a dialkylamino having 1 to 6 carbon atoms; an arylalkenyl which may optionally be substituted with at
least one substituent selected from the group consisting of a halogen, hydroxy, an alkyl having 1 to 6 carbon atoms, an alkoxy
having 1 to 6 carbon atoms, an amino and a dialkylamino having 1 to 6 carbon atoms; an alkyl which may optionally be substituted
with an alicyclic group; an alkenyl which may optionally be substituted with an alicyclic group; an alicyclic group; a heterocyclic
group; or an alkynyl which may optionally be substituted with an alicyclic group, and

R4 is a protecting group selected from the group consisting of methyl, methoxymethyl, tetrahydropyranyl, benzyl, 4-methoxybenzyl,
tert-butyldimethylsilyl, trimethylsilyl, triethylsilyl, phenyldimethylsilyl, tert-butyldiphenylsilyl, and triisopropylsilyl.

US Pat. No. 9,261,740

LIQUID CRYSTAL PANEL

JNC CORPORATION, Tokyo (...

1. A liquid crystal panel having a first substrate and a second substrate that are oppositely arranged, and a liquid crystal
layer interposed between the first substrate and the second substrate, wherein
the first substrate has a plurality of signal lines and scanning lines formed in a matrix, an upper electrode having a plurality
of slit-shaped openings and cross-sectional curve-shaped protruded electrodes alternately formed for every sub-pixel divided
by the scanning lines and the signal lines, and a lower electrode formed with the upper electrode through an insulating layer,
wherein the protruded electrode has a semicircular shape, an elliptic shape or a trapezoidal shape, and

the second substrate has a light-shielding layer superimposed with the signal lines and the scanning lines in a planar view,
and a color filter layer formed for every sub-pixel described above.

US Pat. No. 9,234,134

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition which has a negative dielectric anisotropy and contains at least one compound selected from
the group of compounds represented by formula (1) as a first component and at least one compound selected from the group of
compounds represented by formula (2) as a second component:
wherein, R1 and R3 are independently alkyl having 1 to 12 carbons or alkenyl having 2 to 12 carbons; R2 and R4 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons; ring A and
ring B are independently:
X1 and X2 are independently fluorine or chlorine; Y1 is hydrogen or methyl; Z1 and Z2 are independently a single bond, ethylene, methyleneoxy or carbonyloxy; k is 0 or 1; m and n are independently 0, 1, 2 or
3, and a sum of m and n is 1, 2 or 3; and when n is 1, R4 is alkyl having 1 to 12 carbons or alkenyl having 2 to 12 carbons.

US Pat. No. 9,157,027

COMPOUND HAVING FOUR POLYMERIZABLE GROUPS, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein ring A1, ring A2, ring A3 and ring A4 are independently phenylene or cyclohexylene, and in these groups at least one hydrogen may be replaced by alkyl having 1
to 10 carbons, fluorine, —CF2H or —CF3;
Z1, Z2, Z3 and Z4 are independently a single bond;

L1, L2 and L3 are independently a single bond;

s and t are independently 0 or 1, and the sum of s and t is 0, 1 or 2;
P1, P2, P3 and P4 are independently a group (P-1):


wherein M is hydrogen, fluorine, —CH3 or —CF3; and

when L1 is a single bond and s and t are 0, an alkyl substituent at 2-position of the ring A1 and an alkyl substituent at 2-position of the ring A4 may be bonded with each other to form a ring.

US Pat. No. 9,115,243

ORGANOSILICON COMPOUND, THERMOSETTING RESIN COMPOSITION CONTAINING THE ORGANOSILICON COMPOUND, HARDENING RESIN AND ENCAPSULATION MATERIAL FOR OPTICAL SEMICONDUCTOR

JNC CORPORATION, Tokyo (...

1. A liquid organosilicon compound represented by formula (1) as described below:

wherein, X is each independently a group represented by formula (I), formula (II) or formula (III) as described below, and
when the number of the group represented by formula (I) per one molecule of the liquid organosilicon compound represented
by general formula (1) (or the mean number of groups per one molecule of the compound when the compound is a mixture having
a different ratio for the group represented by formula (I), the group represented by formula (II), and the group represented
by formula (III)) is defined as a, the number of the group represented by formula (II) per one molecule thereof is defined
as b, and the number of the group represented by formula (III) per one molecule thereof is defined as c, 0?a?3.5, 0?b?3.5,
and 0?c?1 are obtained, and also a+b+2c=4 is obtained:


wherein, R? is each independently a group selected from alkyl having 1 to 4 carbons, cyclopentyl and cyclohexyl, R2 and R3 are each independently a group selected from alkyl having 1 to 4 carbons, cyclopentyl, cyclohexyl and phenyl, m and n are
the number of repetitions of —OSi(R3)2—, and a mean value satisfying 1 to 50,

wherein a Pt catalyst is added into the liquid organosilicon compound, and an amount of the Pt catalyst added is in a concentration
range of 0.001 to 0.08 ppm such that a viscosity of the liquid organosilicon compound represented by formula (1) is less than
or equal to 100 Pa·s.

US Pat. No. 9,309,463

LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (I):

wherein, in formula (I), R1 is fluorine, chlorine, or alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, and at least one of —(CH2)2— may be replaced by —CH?CH— or —C?C—;

? and ? are independently cyclohexane-1,3,5-triyl or benzene-1,3,5-triyl, and in the rings, —CH2— may be replaced by —O—, —CH— may be replaced by —N—, and —(CH2)2— may be replaced by —CH?CH—, and in the rings, at least one of hydrogen may be replaced by fluorine, chlorine, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F;

Z is a single bond or unbranched alkylene having 1 to 4 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —CO—, —S— or —SiH2—, at least one of —(CH2)2— may replaced by —CH?CH— or —C?C—, and at least one of hydrogen may be replaced by fluorine; and

MG is represented by formula (II):

wherein, in formula (II), Sp is a single bond or unbranched alkylene having 1 to 10 carbons, and in the alkylene, at least
one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, and at least one of —(CH2)2— may replaced by —CH?CH— or —C?C—; Ra is independently fluorine, chlorine, or unbranched alkyl having 1 to 10 carbons, and
in the alkyl, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, and at least one of —(CH2)2— may be replaced by —CH?CH— or —C?C—;

A1, A2, A3 and A4 are independently 1,4-cyclohexylene, 1,4-phenylene, cyclohexene-1,4-diyl, decahydronaphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl
or naphthalene-2,6-diyl, and in the rings, one of —CH2— may be replaced by —O—,—S—, —CO— or —SiH2—, and at least one of —(CH2)2— may be replaced by —CH?CH—, and in the rings, at least one of hydrogen may be replaced by fluorine, chlorine, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F;

Z1, Z2, Z3 and Z4 are independently a single bond or alkylene having 1 to 4 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, at least one of —(CH2)2— may be replaced by —CH?CH— or —C?C—, and at least one of hydrogen may be replaced by fluorine; and m, n, q and r are independently
0, 1 or 2, and a sum of m, n, q and r is 2, 3, 4 or 5.

US Pat. No. 9,238,681

MUTANT APOPROTEIN OF PHOTOPROTEIN WITH LOW CALCIUM SENSITIVITY

JNC CORPORATION, Tokyo (...

1. An isolated polynucleotide comprising a polynucleotide encoding an isolated mutant apoprotein comprising an amino acid
sequence wherein the 23rd to 34th amino acids in the amino acid sequence of SEQ ID NO: 2 are substituted with an amino acid
represented by formula I below: Xaa23-Xaa24-Xaa25-Xaa26-Xaa27-Xaa28-Xaa29-Xaa30-Xaa31-Xaa32-Xaa33-Xaa34, wherein:
Xaa23 is Asp, Glu, Gin, Ser, Thr, or Asn,
Xaa24 is Lys, Arg, His, Leu, or Thr,
Xaa25 is Asp, Glu, Gin, Ser, Thr, or Asn,
Xaa26 is an optional amino acid,
Xaa27 is Asp, Glu, Gin, Ser, Thr, or Asn,
Xaa28 is Gly,
Xaa29 is an optional amino acid,
Xaa30 is Ile, Leu, or Val,
Xaa31 is Asp, Glu, Gln, Ser, Thr, or Asn,
Xaa32 is an optional amino acid,
Xaa33 is an optional amino acid, and
Xaa34 is Asp, Glu, Gin, Ser, Thr, or Asn;
having a function to bind to the peroxide of coelenterazine or the peroxide of a coelenterazine analogue to form a photoprotein
capable of emitting light under the action of calcium ions; and

having a half decay time of the luminescence emitted by binding of the photoprotein to calcium ions being not less than 2
seconds.

US Pat. No. 9,150,787

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition including at least one compound selected from the group of compounds represented by formula
(1) as a first component and at least one compound selected from the group of compounds represented by formula (2) as a second
component:
wherein in formula (1),
P1 and P2 are independently a group represented by formula (P-1):

wherein in formula (P-1), M1 and M2 are independently hydrogen, fluorine, methyl or trifluoromethyl;
ring A and ring B are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, naphthalene-1,4-diyl, naphthalene-1,5-diyl,
naphthalene-2,6-diyl, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, pyrimidine-2,5-diyl or pyridine-2,5-diyl, and in these
groups at least one hydrogen may be replaced by halogen, alkyl having 1 to 12 carbons, or alkyl having 1 to 12 carbons in
which at least one hydrogen has been replaced by halogen;

Z1 and Z2 are independently alkylene having 2 to 10 carbons in which at least one —CH2—CH2— is replaced by —CH?CH— or —?C—, and in the alkylene at least one —CH2— may be replaced by —O—, —COO—, —OCO— or —OCOO—, wherein at least one of Z1 and Z2 is —CH?CH—O—;

L1 is independently a single bond, —COO— or —CH?CH—; and

q is 0, 1, 2 or 3;and in formula (2),
R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, or alkenyl having 2 to 12 carbons;

ring C and ring E are independently 1,4-cyclohexylene, tetrahydropyran-2,5-diyl, 1,4-phenylene, 2-fluoro-1,4-phenylene or
3-fluoro-1,4-phenylene;

ring D is 2,3-difluoro-1,4-phenylene, 2-chloro-3-fluoro-1,4-phenylene, 2,3-difluoro-5-methyl-1,4-phenylene, 3,4,5-trifluoronaphthalene-2,6-diyl
or 7,8-difluorochroman-2,6-diyl;

Z3 and Z4 are independently a single bond, ethylene, methyleneoxy or carbonyloxy; and

r is 1, 2 or 3, s is 0 or 1, and the sum of r and s is 3 or less.

US Pat. No. 9,070,885

ANTHRACENE COMPOUND AND ORGANIC ELECTROLUMINESCENCE ELEMENT USING SAME

JNC CORPORATION, Tokyo (...

9. An organic electroluminescence element having a pair of electrodes consisting of a positive electrode and a negative electrode
and a light emitting layer containing the light emitting layer material according to claim 8 as disposed between the pair of electrodes.
US Pat. No. 9,063,144

DETECTION METHOD AND QUANTIFICATION METHOD FOR TARGET SUBSTANCE

JNC Corporation, Tokyo (...

1. A method for detecting a target substance in a sample, comprising steps of:
mixing a particle carrying a first bound substance in which a first substance containing a stimuli-responsive polymer binds
to a first affinity substance having affinity to the target substance, a second bound substance in which a hydrophilic second
substance binds to a second affinity substance having affinity to the target substance, and the sample, to obtain a mixture;

placing the mixture under conditions to aggregate the stimuli responsive polymer and developing the mixture thus obtained
on a developing carrier; or developing the mixture on a developing carrier and placing the mixture under conditions to aggregate
the stimuli-responsive polymer;

detecting a signal resulting from the presence of the first bound substance or the second bound substance on the developing
carrier; and in a case where the signal is different from that detected in the absence of the target substance, determining
that the target substance is present in the sample,

wherein the first affinity substance and the second affinity substance can bind to different sites of the target substance,
the hydrophilic second substance is capable of inhibiting aggregation of the stimuli-responsive polymer,

wherein the developing carrier is a chromatography carrier that is a perforated membrane, such that a non-aggregated body
having a diameter smaller than a pore diameter of the developing carrier moves on the developing carrier and an aggregate
having a diameter larger than the pore diameter of the developing carrier does not move on the developing carrier, and

wherein the conditions to aggregate the stimuli-responsive polymer comprise a stimulus, such that the stimuli-responsive polymer
aggregates in response to the stimulus.

US Pat. No. 9,422,652

STRETCHABLE BULKY NONWOVEN FABRIC AND METHOD FOR MANUFACTURING SAME

JNC CORPORATION, Tokyo (...

1. A stretchable bulky nonwoven fabric, wherein a first fibrous layer including fibers (1) is laminated with a second fibrous layer including heat fusible fibers (2) and having a MD shrinkage ratio that is lower by 5% or more than a MD shrinkage ratio of the first fibrous layer, the first
fibrous layer and the second fibrous layer are integrated by partial entanglement of the fibers (1) included in the first fibrous layer and the fibers (2) included in the second fibrous layer at an interface between the first fibrous layer and the second fibrous layer in a thickness
direction of the nonwoven fabric, wherein partial entanglement comprises entanglements and regions between the entanglements,
the first fibrous layer is shrunk to form a structure in which the second fibrous layer is raised in a thickness direction
at the regions between the entanglements, and sonic bond processing is partially applied to the first and second fibrous layers
from a side of the second fibrous layer after the entanglement and shrinkage, wherein the entanglement and shrinkage are simultaneously
achieved by increasing a temperature to a level in which helical crimps are developed in fibers (1) or to a higher level, and the fibers (1) develop helical crimps and shrink so as to tangle the fibers (2) included in the second fibrous layer.

US Pat. No. 9,404,040

LIQUID CRYSTAL COMPOUND HAVING FLUORINE-CONTAINING ALKENYL TERMINAL GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein, in formula (1),
R is hydrogen, alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons, alkoxy having 1 to 9 carbons, alkoxyalkyl having
2 to 9 carbons or alkenyloxy having 2 to 9 carbons;

ring A1, ring A2 and ring A3 are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, pyrimidine-2,5-diyl,
pyridine-2,5-diyl, naphthalene-2,6-diyl, decahydronaphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl, 1,4-phenylene,
2-fluoro-1,4-phenylene or 2,3-difluoro-1,4-phenylene;

L1 and L2 are independently hydrogen, fluorine or chlorine, and at least one of L1 and L2 is fluorine;

Z1, Z2, and Z3 are independently a single bond, —(CH2)2—, —CH2O—, —OCH2—, —COO—, —OCO—, —CF2O—, or —OCF2—;

x and y are independently an integer from 0 to 10; and
l and m are independently 0, 1 or 2, and n is independently 1 or 2, and a sum of 1, m and n is 1, 2 or 3.

US Pat. No. 9,372,187

DETECTION METHOD AND DETERMINATION METHOD FOR DETECTION TARGET

ORTHO-CLINICAL DIAGNOSTIC...

1. A method for detecting a target substance in a sample, comprising steps of:
mixing a first bound substance in which a first substance containing a stimuli-responsive polymer binds to a first affinity
substance having affinity to the target substance, a second bound substance in which a hydrophilic second substance binds
to a second affinity substance having affinity to the target substance, and the sample; placing the mixture under conditions
to aggregate the stimuli-responsive polymer; and determining if the stimuli-responsive polymer is dispersed or not, wherein

the first affinity substance and the second affinity substance can simultaneously bind to different sites of the target substance;
and determining that the target substance is present in a case in which aggregation inhibition of the stimuli-responsive polymer
is confirmed via inhibition of the aggregation of the stimuli-responsive polymer by the second bound substance, and that the
target substance is not present in a case in which aggregation inhibition of the stimuli-responsive polymer is not confirmed;
wherein the step of determining if dispersion is present or not is carried out under conditions to aggregate the stimuli-responsive
polymer.

US Pat. No. 9,315,783

CODON-OPTIMIZED GENE FOR MUTATED SHRIMP LUCIFERASE AND METHOD FOR USE THEREOF

JNC CORPORATION, Tokyo (...

1. An isolated polynucleotide selected from the group consisting of (a) to (d) below:
(a) a polynucleotide comprising a polynucleotide consisting of the nucleotide sequence of SEQ ID NO: 2;
(b) polynucleotide comprising a polynucleotide encoding a protein consisting of a nucleotide sequence in which 1 to 20 nucleotides
are deleted, substituted, inserted and/or added in the nucleotide sequence of SEQ ID NO: 2, and having a luminescent catalyst
activity by using luciferin as a substrate;

(c) a polynucleotide comprising a polynucleotide encoding a protein consisting of a nucleotide sequence having at least 90%
identity to the nucleotide sequence of SEQ ID NO: 2, and having a luminescent catalyst activity by using lucifeuin as a substrate;
and,

(d) a polynucleotide comprising a polynucleotide encoding a protein which hybridizes to a polynucleotide consisting of a nucleotide
sequence complementary to the nucleotide sequence of SEQ ID NO: 2 under high stringency conditions, and has a luminescent
catalyst activity by using luciferin as a substrate, wherein the high stringency conditions are 5×SSC, 5×Denhardt's solution,
0.5% (w/v) SDS, 50% (v/v) formamide, and 50° C.

US Pat. No. 9,283,542

CHROMATOGRAPHY MEDIUM, PREPARATION METHOD OF THE SAME, AND METHOD FOR PRODUCING VIRUS VACCINE USING THE CHROMATOGRAPHY MEDIUM

JNC CORPORATION, Tokyo (...

1. A chromatography medium, formed by binding a sulfated polysaccharide to porous particles having an exclusion limit molecular
weight of 6000 Da or less when pure water is used as mobile phase and standard polyethylene glycol is used, wherein the chromatography
medium is of General Formula (1) below:
X—O—CH2—C(OH)H—CH2—NH—CH2—Z  (1)

wherein in Formula (1), X is the porous particle have an average particle size in the range of 30-200 ?m, bonded to X is an
oxygen originating from hydroxyl of the porous particle, Z is the sulfated polysaccharide, and C bonded to Z is a carbon originating
from the reductive end of the sulfated polysaccharide, wherein sulfated polysaccharide is a ligand, and a limiting viscosity
of the sulfated polysaccharide is in the range of 0.40-0.90 dL/g.

US Pat. No. 9,109,157

LIQUID CRYSTAL COMPOUND HAVING NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE USING THE SAME

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (i):

wherein R1 and R2 are independently alkyl having 1 to 8 carbons;

ring A1 is trans-1,4-cyclohexylene, 1,4-cyclohexenylene or 1,4-phenylene;

ring A2 is trans-1,4-cyclohexylene, 1,4-cyclohexenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene, 2,3-difluoro-1,4-phenylene,
2-fluoro-3-chloro-1,4-phenylene or 2-chloro-3-fluoro-1,4-phenylene;

Q1 and Q2 are fluorine; and

h is 0 or, and when h is 0, ring A1 is trans-1,4-cyclohexylene or 1,4-cyclohexenylene.

US Pat. No. 9,074,132

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition containing at least one compound selected from the group of compounds represented by formula
(1) as a first component, at least one compound selected from the group of compounds represented by formula (2) as a second
component, and at least one compound selected from the group of compounds represented by formula (3-1) as a third component:
wherein P1 and P2 are independently a group selected from groups represented by formula (P-1) to formula (P-6);
R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons; R3 is independently ethyl or vinyl; R4 is propyl; ring A and ring B are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, tetrahydropyran-2,5-diyl,
1,3-dioxane-2,5-diyl or pyrimidine-2,5-diyl, and in the groups, at least one of hydrogen may be replaced by halogen or alkyl
having 1 to 12 carbons, or alkyl having 1 to 12 carbons in which at least one of hydrogen is replaced by halogen; ring C and
ring E are independently 1,4-cyclohexylene, tetrahydropyran-2,5-diyl, 1,4-phenylene, 2-fluoro-1,4-phenylene or 3-fluoro-1,4-phenylene;
ring D is 2,3-difluoro-1,4-phenylene, 2-chloro-3-fluoro-1,4-phenylene, 2,3-difluoro-5-methyl-1,4-phenylene, 3,4,5-trifluoronaphthalene-2,6-diyl
or 7,8-difluorochroman-2,6-diyl; Sp is —C?C—O—, —C?C—, —C—C?C—, —O—, —C—C—O—, or —(CO)—O—; Z1, Z2, and Z3 are independently a single bond, ethylene, methyleneoxy or carbonyloxy; k is 0, 1, 2 or 3; m is 1, 2 or 3; and n is 0 or 1,
and a sum of m and n is 3 or less.
US Pat. No. 9,505,850

ENDOTOXIN ADSORBENT

NATIONAL UNIVERSITY CORPO...

1. A method for removing endotoxin, comprising bringing a solution containing an objective material showing a negative charge
and endotoxin into contact with a polymer of cyclodextrin or an adsorbent containing a base material and the polymer as immobilized
to the base material,
wherein the polymer has features (1) to (4) described below:
(1) N/C shown according the following formula is 6 to 15;
N/C(mol %)=nitrogen content(mol)/carbon content(mol)×100  (formula 1)
(2) part of hydroxy group of cyclodextrin forms a urethane bond;
(3) insoluble in water; and
(4) anion exchange capacity is less than 0.1 meq/g.
US Pat. No. 9,181,318

METHOD OF SCREENING A DRUG SUCH AS INSULIN SECRETAGOGUE

JNC Corporation, Tokyo (...

1. A method of screening a substance regulating insulin secretion from a cell, which comprises:
contacting a cell transformed with a polynucleotide encoding a fusion protein of preproinsulin and a luciferase with a test
substance, and

detecting luminescence of the luciferase to measure a level of insulin secretion,
wherein the luciferase is Gaussia luciferase, and

wherein Gaussia luciferase is a protein of any one of (a) through (c) below:

(a) a protein comprising the amino acid sequence of SEQ ID NO: 8;
(b) a protein consisting of an amino acid sequence comprising deletion, substitution, insertion and/or addition of 1 to 10
amino acid residues in the amino acid sequence of SEQ ID NO: 8, and having substantially the same activity as a protein consisting
of the amino acid sequence of SEQ ID NO: 8;

(c) a protein consisting of an amino acid sequence having at least 90% identity to the amino acid sequence of SEQ ID NO: 8,
and having substantially the same activity as the protein consisting of the amino acid sequence of SEQ ID NO: 8; and,

wherein the preproinsulin consists of a signal peptide of preproinsulin and the polypeptide of any one of (i) through (k)
below:

(i) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 4;
(j) a polypeptide comprising a polypeptide consisting of an amino acid sequence comprising deletion, substitution, insertion
and/or addition of 1 to 10 amino acid residues in the amino acid sequence of SEQ ID NO: 4, and having an insulin activity;

(k) a polypeptide comprising a polypeptide consisting of an amino acid sequence having at least 90% identity to the amino
acid sequence of SEQ ID NO: 4, and having an insulin activity; and,

wherein the signal peptide of preproinsulin is a polypeptide consisting of the amino acid sequence of SEQ ID NO: 6.
US Pat. No. 9,146,232

METHOD FOR STABILIZING PROTEIN

JNC Corporation, Tokyo (...

1. A method for stabilizing a protein, comprising:
allowing a peptide obtained by hydrolyzing collagen or gelatine from fish and a calcium-binding photoprotein to be in the
same system, wherein the peptide is derived from at least one of the following fish species: sardine, saucy, sparid, salmon,
herring, or carp; and

lyophilizing the system.

US Pat. No. 9,487,703

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a nematic phase and contains at least one compound represented by formula (1) as
a first component and at least one compound represented by formula (2) as a second component:

wherein in formulas (1) and (2), R is alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12
carbons; R2 is alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkyl having 1 to 12 carbons
in which at least one hydrogen is replaced by halogen, or alkenyl having 2 to 12 carbons in which at least one hydrogen is
replaced by halogen; R3 is alkenyl having 2 to 12 carbons, or alkenyl having 2 to 12 carbons in which at least one hydrogen is replaced by halogen;
ring A is 1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 2,3-difluoro-1,4-phenylene, 2,6-difluoro-1,4-phenylene,
pyrimidine-2,5-diyl, 1,3-dioxane-2,5-diyl, tetrahydropyran-2,5-diyl or naphthalene-2,6-diyl; Z1 is a single bond, ethylene, vinylene, methyleneoxy, carbonyloxy or difluoromethyleneoxy, wherein at least one of Z1 is difluoromethyleneoxy; X1 and X2 are independently hydrogen or fluorine; and j is 1, 2, 3 or 4.

US Pat. No. 9,486,979

NONWOVEN FABRIC WITH SURFACE UNEVEN STRUCTURE, AND PRODUCT USING SAME

JNC Corporation, Tokyo (...

1. A nonwoven fabric having a surface concavo-convex structure,
which is formed by pressing a planar element having a plurality of apertures against at least one surface of a nonwoven fabric
that has been treated by passing hot air through a web comprising heat adhesive fibers so as to heat-bond the heat adhesive
fibers in the nonwoven fabric at interlacing points between the heat adhesive fibers,

wherein the nonwoven fabric is heat-bonded entirely across the heat adhesive fibers at the interlacing points between the
heat adhesive fibers,

the pressing process is performed in a state in which the nonwoven fabric is heated in a degree that does not further promote
the heat bonding,

bulky hill parts forming convex parts in the surface concavo-convex structure and less bulky plain parts forming concave parts
in the surface concavo-convex structure are intermingled with each other on the surface of the nonwoven fabric including the
heat adhesive fibers,

each of the bulky hill parts forming the convex parts is formed at a position corresponding to one of the plurality of the
apertures of the planar element, and each of the less bulky plain parts forming the concave parts is formed at a position
corresponding to one part of a non-aperture area of the planar element, when the planar element is pressed against the nonwoven
fabric,

the concave parts in a shape of a plain at the positions corresponding to the non-aperture area of the planar element surround
the convex parts and form a network linking the concave parts with each other via the plain of the nonwoven fabric,

the bulky hill parts of the nonwoven fabric are formed so that a bulkiness of the bulky hill parts is not suppressed toward
a space above the bulky hill parts, while the heat adhesive fibers in the bulky hill parts are heat-bonded at the interlacing
points between the heat adhesive fibers in the bulky hill parts,

the heat adhesive fibers are heat adhesive conjugated fibers,
the heat adhesive conjugate fibers in the web are heat adhesive conjugate fibers that have been cut, and
wherein the nonwoven fabric has an apparent specific volume in a range from 20 to 70 cm3/g.

US Pat. No. 9,394,482

POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in formula (1),
all of a1 moieties of P1 and a2 moieties of P2 are identically a group selected from groups represented by formulas (P-1), (P-2) and (P-3), and in formula (P-1), M is hydrogen,
fluorine, —CH3 or —CF3:


S1 and S2 are independently a single bond or alkylene having 1 to 6 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —COO— or —OCO—, at least one of —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and in the group, at least one of hydrogen may be replaced by halogen;

a1 and a2 are independently 0, 1, 2, 3 or 4, and a sum of a1 and a2 is 4;
ring A1 is naphthalene, anthracene or phenanthrene, ring A2 is cyclohexyl, phenyl, naphthyl, anthracenyl or phenanthrenyl, and in the rings, at least one of hydrogen may be replaced
by halogen, alkyl having 1 to 10 carbons, or alkyl having 1 to 10 carbons in which at least one of hydrogen is replaced by
halogen;

Z1 is a single bond, —CO—, —COO—, —OCO—, —CH?CH—, —C?C—, —CH?C(CH3)—, —C(CH3)?CH—, —C(CH3)?C(CH3)—, —CH?CH—COO—, —OCO—CH?CH—, —C(CH3)?CH—COO—, —OCO—CH?CH(CH3)—, —CH?C(CH3)—COO—, —OCO—C(CH3)?CH—, —C(CH3)?C(CH3)—COO—, —OCO—C(CH3)?C(CH3)—, —CH?CH—CO—, —CO—CH?CH—, —CH?CH—CH2O—, —OCH2—CH?CH—, —CH?CH—OCH2— or —CH2O—CH?CH—; and

b1 is 0, 1, 2, 3 or 4;
wherein when b1 is 0, ring A1 is anthracene or phenanthrene.

US Pat. No. 9,327,050

HEMOSTATIC MATERIAL CONTAINING NANO-FIBER CONTAINING SYNTHETIC COLLAGEN

JNC CORPORATION, Tokyo (...

1. A hemostatic material, comprising a nano-fiber that comprises: a polymer, and a polypeptide having a peptide fragment of
formula (1):
-(Pro-Y-Gly)n-  (1)

wherein Y represents hydroxyproline or proline, and n is an integer ranging from 5 to 9000,
wherein the polymer comprises at least one selected from the group consisting of natural collagen, polyethylene glycol, polyvinyl
alcohols and polyglycolic acids, and

wherein the nano-fiber has an average length of 200 to 300 nm.

US Pat. No. 9,228,129

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition having a nematic phase and comprising at least one compound selected from the group of compounds
represented by formula (1) as a first component and at least one compound selected from the group of compounds represented
by formula (2) as a second component:
in formula (1) and formula (2), R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons; R3 is alkenyl having 2 to 12 carbons or alkenyl having 2 to 12 carbons in which at least one hydrogen has been replaced by fluorine;
ring A is 1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 2,6-difluoro-1,4-phenylene, pyrimidine-2,5-diyl, 1,3-dioxane-2,5-diyl
or tetrahydropyran-2,5-diyl; Z1 is a single bond, ethylene, vinylene, methyleneoxy, carbonyloxy or difluoromethyleneoxy; X1, X2 and X13 are independently hydrogen or fluorine; and n is 1, 2, 3 or 4.

US Pat. No. 9,045,684

LIQUID CRYSTAL COMPOSITION, ANTIOXIDANT AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a nematic phase and contains at least one compound selected from the group of compounds
represented by formula (1) as a first component:

wherein, R1 is alkyl having 2 to 20 carbons, and in the alkyl, at least one of —CH2— is replaced by —O— or —S— or not; R2, R3, R4 and R5 are independently hydrogen or methyl;

ring A is 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 1,3 -dithiane-2,5-diyl, tetrahydropyran-2,5-diyl, or 1,4-phenylene in which
at least one of hydrogen is replaced by fluorine or not; Z1 is a single bond, —CH2CH2—, —CH?CH—, —C?C—, —COO—, —OCO—, —CH2O—, —OCH2—, —CF?CF—, —CH2S— or —SCH2—; and m is 0 or 1.

US Pat. No. 9,422,294

CYCLIC COMPOUND, METHOD FOR PRODUCING CYCLIC COMPOUND, AND METHOD FOR MODIFYING BIOLOGICAL MOLECULE

JNC CORPORATION, Tokyo (...

1. A method for producing a cyclic compound, which comprises adding and ligating an azide compound having an azido group to
each of the two carbon-carbon triple bond sites on the cyclic skeleton in a cyclic diyne compound by a double click reaction
to produce a cyclic compound comprising two triazole rings.

US Pat. No. 9,316,882

LIQUID CRYSTAL PANEL

JNC CORPORATION, Tokyo (...

1. A liquid crystal panel having a first substrate and a second substrate that are oppositely arranged, and a liquid crystal
layer interposed between the first substrate and the second substrate, wherein
the first substrate has a plurality of signal lines and scanning lines formed in a matrix, an upper electrode having a plurality
of slit-shaped openings formed for every sub-pixel divided by the scanning lines and the signal lines, and a lower electrode
formed with the upper electrode through an insulating layer,

the second substrate has a light-shielding layer superimposed with the signal lines and the scanning lines in a planar view,
and a color filter layer formed for every sub-pixel described above, and

the liquid crystal layer is formed of a mixture of at least one compound having a negative dielectric anisotropy and at least
one compound having a positive dielectric anisotropy.

US Pat. No. 9,279,078

HARDENING RESIN COMPOSITION AND COLOR CONVERSION MATERIAL USING THE SAME

JNC CORPORATION, Tokyo (...

1. A hardening resin composition containing (A) to (E) below:
(A) a silicon compound that is obtained by performing a hydrosilylation reaction among compound (a), compound (b), and when
necessary, compound (c) below, and has at least one of epoxy and oxetanyl, wherein

compound (a) is at least one of silicone and silsesquioxane having two or more of SiH in one molecule and is at least one
kind selected from the group of compounds represented by formula (a-1) to formula (a-5) and formula (a-7) to formula (a-10)
below,


wherein, in formula (a-1) to formula (a-5) and formula (a-7) to formula (a-10),
R is a group independently selected from alkyl having 1 to 45 carbons, cycloalkyl having 4 to 8 carbons, aryl having 6 to
14 carbons and arylalkyl having 7 to 24 carbons; in the alkyl having 1 to 45 carbons, arbitrary hydrogen may be replaced by
fluorine, and arbitral non-adjacent —CH2— may be replaced by —O— or —CH?CH—; in a benzene ring in the aryl and the arylalkyl, arbitrary hydrogen may be replaced by
halogen or alkyl having 1 to 10 carbons, and in the alkyl having 1 to 10 carbons, arbitrary hydrogen may be replaced by fluorine,
and arbitrary non-adjacent —CH2— may be replaced by —O— or —CH?CH—; the number of carbons of alkylene in the arylalkyl is 1 to 10, and arbitrary non-adjacent
—CH2—may be replaced by —O—;

R1 and R2 are a group independently selected from alkyl having 1 to 4 carbons, cyclopentyl, cyclohexyl and phenyl;

R3 is a group independently selected from alkyl having 1 to 4 carbons, cyclopentyl, cyclohexyl and phenyl;

at least two of X, in one molecules of each compound, are hydrogen, and the rest of X is a group independently selected from
alkyl having 1 to 4 carbons, cyclopentyl, cyclohexyl and phenyl; and

n is an integer from 0 to 100, and m is an integer from 3 to 10;
compound (b) is a compound having at least one of epoxy and oxetanyl, and alkenyl having 2 to 18 carbons in one molecule,
and compound (c) is at least one of silicone and silsesquioxane having two or more of alkenyl in one molecule;
(B) a phosphor;
(C) an epoxy resin;
(D) a hardening agent; and
(E) an antioxidant.

US Pat. No. 9,133,397

TRICYCLIC COMPOUND HAVING A PLURALITY OF CF2O BONDING GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1);

wherein, in formula (1),
R1 is hydrogen, halogen or alkyl having 1 to 20 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O— or —S—, at least one of —(CH2)2— may be replaced by —CH?CH—, and at least one of hydrogen may be replaced by halogen;

ring A1 is 1,4-cyclohexylene, 2-fluoro-1,4-phenylene, 2,6-difluoro-1,4-phenylene, 1,3-dioxane-2,5-diyl or tetrahydropyran-2,5-diyl;

ring A2 is 1,4-phenylene, 2-fluoro-1,4-phenylene, or 2,6-difluoro-1,4-phenylene;

ring A3 is 2 fluoro-1,4-phenylene, or 2,6-difluoro-1,4-phenylene; and

X1 is hydrogen, halogen, —C?N, —N?C?S, —SF5 or alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O— or —S—, at least one of —(CH2)2— may be replaced by —CH?CH—, and at least one of hydrogen may be replaced by halogen.

US Pat. No. 9,102,871

LIQUID CRYSTAL COMPOUND SHOWING NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in formula (1),
one of Y1 and Y2 is fluorine, and the other is CF2H or CF3;

G is a ring represented by formula (pr-1) or formula (pr-2):

wherein
A1 to A3 are independently 1,4-cyclohexylene or 1,4-phenylene;

Ra and Rb are independently hydrogen or alkyl having 1 to 20 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, —S— or —CO—, and at least one of —(CH2)2— may be replaced by —CH?CH—;

Z0, and Z1 to Z3 are independently a single bond, —(CH2)—CH?CH—, —CF2O—, —OCF2—, —CH2O—, —OCH2—, —COO— or —OCO—;

j, m and n are an integer from 0 to 2, and a sum of j, m and n is 0, 1 or 2, a plurality of -A1-Z1— may be identical with or different from each other when j is 2, a plurality of -A2-Z2— may be identical with or different from each other when m is 2, and a plurality of —Z3-A3- may be identical with or different from each other when n is 2,

however, G is a ring represented by formula (pr-1) when m is 0, Y1 is CF2H or CF3, Y2 is fluorine, and Z0 is a single bond.

US Pat. No. 9,059,410

LIQUID CRYSTALLINE ORGANIC SEMICONDUCTOR MATERIAL AND ORGANIC SEMICONDUCTOR DEVICE USING SAME

NATIONAL INSTITUTE OF ADV...

1. A liquid crystalline organic semiconductor material having substituents on the periphery of a rigid plate-like central
structure, wherein the substituents have a fluorinated phenylene group and columns in which a liquid crystalline compound
is accumulated in a stack and are aligned in the shape of a hexagonal crystal, comprising at least one compound selected from
the group of compounds represented by formula (1):

in formula (1), R is independently hydrogen, a C12 to C24 linear or branched alkyl; in the alkyl, any —CH2—may be replaced by —O—, and —CO—, any —(CH2)2— may be replaced by —CH?CH— or —C?C—, and any hydrogen may be replaced by a halogen;

A is independently 1,4-phenylene in which any hydrogen is replaced by fluorine;
Z is independently a single bond, —(CH2)2—, —COO—, —OCO—, —CONH—, —NHCO—, —CH2O—, —OCH2—, —CF2O—, —OCF2—, —CH?CH—, —C?C—, —CF?CF—, —CH2CO—, or —COCH2;

and n is 1.

US Pat. No. 9,499,744

DIHYDROPYRAN COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein, in formula (1),
Ra and Rb are independently alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, and at least one of —CH2CH2— may be replaced by —CH?CH— or —C?C—;

ring A1, A2, A3 and A4 are independently 1,4-cyclohexylene, decahydronaphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl,
1,4-phenylene, naphthalene-2,6-diyl, 9,10-dihydrophenanthrene-2,7-diyl, 9H-xanthene-2,6-diyl or 9H-fluorene-2,7-diyl, and
in the groups, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, at least one of —CH2CH2— may be replaced by —CH?CH— or —CH?N—, and in the divalent groups, at least one of hydrogen may be replaced by fluorine,
chlorine, —C?N, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F; and

P is a divalent group represented by formula (pr-1) or (pr-2):
wherein, Z1, Z2, Z3 and Z4 are independently a single bond or alkylene having 1 to 6 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, one or two of —CH2CH2— may be replaced by —CH?CH— or —C?C—, and in the divalent groups, at least one of hydrogen may be replaced by fluorine or
chlorine;
a, b, c and d are independently 0, 1 or 2, and a sum of a, b, c and d is 5 or less;
however, when P is represented by formula (pr-1), Ra is alkyl, Rb is alkoxy, a is 1, b is 0, c and d are 1, A1 is cyclohexylene, A3 and A4 are 2,3-difluorophenylene, Z1 and Z4 are a single bond and Z3 is alkylene having 2 carbons, in the alkylene, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, or one of —CH2CH2— may be replaced by —CH?CH— or —C?C—, and in the divalent groups, at least one of hydrogen may be replaced by fluorine or
chlorine;

moreover, when P is represented by formula (pr-2), Ra is alkoxy, Rb is alkyl, a and b are 1, c is 1, d is 0, A1 and A2 are 2,3-difluorophenylene, A3 is cyclohexylene, Z1 and Z3 are a single bond and Z2 is alkylene having 2 carbons, in the alkylene, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, or one of —CH2CH2— may be replaced by —CH?CH— or —C?C—, and in the divalent groups, at least one of hydrogen may be replaced by fluorine or
chlorine.

US Pat. No. 9,057,018

POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, AND POLYMER THEREOF

JNC CORPORATION, Tokyo (...

1. A polymerizable liquid crystal compound represented by the formula (1):
wherein
Ra independently represents a polymerizable group represented by one of the formulae (p-1) to (p-6), chlorine, fluorine, cyano,
alkyl having from 1 to 10 carbon atoms, alkoxy having from 1 to 10 carbon atoms, —CF3 or —OCF3:

wherein Rb1 and Rb2 independently represent hydrogen, halogen, alkyl having from 1 to 5 carbon atoms or halogenated alkyl having from 1 to 5 carbon
atoms, and wherein at least one Ra represents a polymerizable group represented by one of the formulae (p-1) to (p-6);
A independently represents 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, naphthalen-2,6-diyl, tetrahydronaphthalen-2,6-diyl,
fluoren-2,7-diyl or bicycle [2.2.2]octan-1,4-diyl; in which one or two —CH2— in the 1,4-cyclohexylene may be replaced by —O— provided that two —CH2— adjacent to each other are not replaced simultaneously, one or two —CH? in the 1,4-phenylene may be replaced by —N?, and
arbitrary hydrogen in the 1,4-phenylene may be replaced by halogen, cyano, alkyl having from 1 to 5 carbon atoms or halogenated
alkyl having from 1 to 5 carbon atoms;

Z independently represents a single bond or alkylene having from 1 to 20 carbon atoms; in which in the alkylene, arbitrary
—CH2— may be replaced by —O—, —CO—, —COO—, —OCO—,—CH?CH—, —CF?CF— or —C?C—, and arbitrary hydrogen may be replaced by halogen;

Y independently represents a single bond or alkylene having from 1 to 20 carbon atoms; in which in the alkylene, arbitrary
—CH2—may be replaced by —O—, —CO—, —COO—, —OCO—, —OCOO— or —CH?CH—, and arbitrary hydrogen may be replaced by halogen; and

m and n independently represent an integer of from 0 to 5.

US Pat. No. 9,057,019

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a positive dielectric anisotropy, and contains at least one compound selected from
the group of compounds represented by formula (1) as a first component and at least one compound selected from the group of
compounds represented by formula (2) as a second component:
wherein R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkenyl
having 2 to 12 carbons in which at least one hydrogen is replaced by fluorine; ring A, ring B, ring C and ring D are independently
1,4-cyclohexylene, 1,4-phenylene, 3-fluoro-1,4-phenylene, 3,5-difluoro-1,4-phenylene, pyrimidine-2,5-diyl, 1,3-dioxane-2,5-diyl
or tetrahydropyran-2,5-diyl; X1, X2, X3 and X4 are independently fluorine or chlorine; L1 is hydrogen or fluorine; Y1 is fluorine, chlorine, trifluoromethyl or trifluoromethoxy; m and p are independently 1, 2, or 3, n and q are independently
0, 1 or 2, a sum of m and n and a sum of p and q are 3 or less, and when one of two rings C in a case where p is 2 is 1,4-cyclohexylene,
the other is not 1,4-phenylene.

US Pat. No. 9,399,736

OPTICALLY ANISOTROPIC SUBSTANCE AND LIQUID CRYSTAL DISPLAY

JNC CORPORATION, Tokyo (...

1. An optically anisotropic substance in which an alignment film, a positive uniaxial phase difference film and a negative
uniaxial phase difference film are formed on a substrate in the above order, wherein
the positive uniaxial phase difference film is formed of polymerizable liquid crystal composition (A) containing one kind
or two or more kinds of achiral polymerizable liquid crystal compounds having two or more polymerizable groups,

the negative uniaxial phase difference film is formed of polymerizable liquid crystal composition (B) containing one kind
or two or more kinds of achiral polymerizable liquid crystal compounds having two or more polymerizable groups, and one kind
or two or more kinds of optically active compounds having a polymerizable binaphthol moiety, and

the optically anisotropic substance is formed according to an additional thermosetting treatment step after the negative uniaxial
phase difference film is formed by photocuring, and

when a glass transition temperature after the negative uniaxial phase difference film is photocured is 85° C. or higher and
115° C. or lower, an additional thermosetting treatment temperature is adjusted to 220° C. or higher and 250° C. or lower,
and when the glass transition temperature is higher than 115° C., the additional thermosetting treatment temperature is adjusted
to 200° C. or higher and 250° C. or lower.

US Pat. No. 9,394,272

1,3-DIOXANE COMPOUND HAVING FLUORINE ATOM IN AXIAL POSITION, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein, in formula (1),
R1 and R2 are independently alkyl having 1 to 15 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O— or —S—, and at least one of —(CH2)2— may be replaced by —CH?CH—;

ring A1, ring A2 and ring A3 are independently 1,4-cyclohexylene, 1,4-phenylene, 1,4-phenylene in which at least one of hydrogen is replaced by halogen,
tetrahydropyran-2,5-diyl, or tetrahydropyran-2,5-diyl in which at least one of hydrogen is replaced by halogen, and in the
rings, at least one of —(CH2)2— may be replaced by —CH?CH—, and at least one of ring A1, ring A2 and ring A3 is represented by formula (A):

wherein, X1 and X2 are independently hydrogen or halogen; and
Z1, Z2 and Z3 are independently a single bond, —(CH2)2—, —CH?CH—, —C?C—, —COO—, —OCO—, —CH2O—, —OCH2—, —CF2O—, —OCF2— or —CF?CF—, wherein, in the case where both X1 and X2 are fluorine when ring A1 is represented by formula (A), Z1 is —(CH2)2—, —CH?CH—, —CH2O— or —OCH2—; and
a, b and c are independently 0 or 1, and a sum of a, b and c is 1, 2 or 3.

US Pat. No. 9,365,772

COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a nematic phase and contains at least one compound selected from the group of compounds
represented by formula (1) as a first component and at least one compound selected from the group of compounds represented
by formula (2) as a second component, in which a proportion of the first component is in a range of 25 wt % to 85 wt % based
on a total weight of the liquid crystal composition:

wherein R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, or alkenyl having 2 to 12 carbons; ring A,
ring B and ring C are independently 1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene, 3,5-difluoro-1,4-phenylene,
pyrimidine-2,5-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl or tetrahydropyran-2,5-diyl; X1 and X2 are independently hydrogen or fluorine; Y1 and Y2 are independently fluorine, chlorine, trifluoromethyl or trifluoromethoxy; Z1, Z2, Z3 and Z4 are independently a single bond, ethylene, carbonyloxy or difluoromethyleneoxy; m and n are 0, 1, 2 or 3, and a sum of m and
n is 2 or 3; and p is 1, 2, 3 or 4.

US Pat. No. 9,193,908

COMPOUND HAVING DIHYDROPHENANTHRENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition comprising:
a compound represented by formula (1) and a compound represented by formula (10):

wherein, in formula (1), R1 is hydrogen, alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons, alkoxy having 1 to 9 carbons, alkoxyalkyl having
2 to 9 carbons or alkenyloxy having 2 to 9 carbons, and in the alkyl, the alkenyl, the alkoxy, the alkoxyalkyl and the alkenyloxy,
at least one of hydrogen may be replaced by fluorine, and R2 is alkoxy having 1 to 9 carbons or alkenyloxy having 2 to 9 carbons;

ring A1, ring A2 and ring A3 are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, tetrahydropyran-2,5-diyl or 1,3-dioxane-2,5-diyl,
and in the rings, at least one of hydrogen may be replaced by fluorine;

Z1 and Z2 are independently a single bond, —(CH2)2—, —OCH2—, —CH2O—, —CF2O— or —OCF2—;

l and m are independently 0 or 1; and
a sum of 1 and m is 1 or 2; and
in formula (10), R5 and R6 are independently alkyl having 1 to 10 carbons or alkenyl having 2 to 10 carbons, and in the alkyl and the alkenyl, at least
one of hydrogen may be replaced by fluorine, and at least one of —CH2— may be replaced by —O—;

ring D1, ring D2 and ring D3 are independently 1,4-cyclohexylene, pyrimidine-2,5-diyl, 1,4-phenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene or
2,5-difluoro-1,4-phenylene; and

Z8 is —C?C—, —COO—, —(CH2)2—, —CH?CH— or a single bond.

US Pat. No. 9,075,058

COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES

JNC CORPORATION, Tokyo (...

1. A compound represented by general formula (IV) below:
wherein R2?? is a group selected from the groups below:
and R3?? hydrogen atom, bromine atom, a substituted or unsubstituted aryl, a substituted or unsubstituted arylalkyl, a substituted
or unsubstituted arylalkenyl, a substituted or unsubstituted arylalkynyl, an alkyl which may optionally be substituted with
an alicyclic group, an alkenyl which may optionally be substituted with an alicyclic group, an alkynyl which may optionally
be substituted with an alicyclic group, an alicyclic group, or a heterocyclic group.

US Pat. No. 9,478,750

ANTHRACENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT USING THE SAME

JNC CORPORATION, Tokyo (...

1. An anthracene derivative represented by the following formula (1):

wherein
Ars are each independently divalent or trivalent benzene or naphthalene,
Rs are each independently hydrogen or an alkyl having a carbon number of 1 to 6, with which Ar or pyridine is substituted,
and not all Rs are hydrogen simultaneously, and

R1, R2, R3 and R4 are each independently hydrogen, an alkyl having a carbon number of 1 to 6, a cycloalkyl having a carbon number of 3 to 6
or an aryl having a carbon number of 6 to 20.

US Pat. No. 9,440,939

NORBORNENE DERIVATIVE

JNC CORPORATION, Tokyo (...

1. A method for producing a compound, comprising:
a) a Diels-Alder reaction step of reacting cyclopentadiene with a compound of formula (A) to obtain a compound (B);

b) a reduction step of reducing the compound (B) to obtain a compound (C) represented by formula (C);

c) an esterification step of esterifying the hydroxyl group of the compound (C); and
d) an epoxidation step of oxidizing the unsaturated bond of the norbornene skeleton of the compound (C),
wherein step a) and step b) are followed by either step c) or step (d), and the compound being produced is represented by
formula (E),


wherein in formulae (A), (B), (C) and (E), R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R3 represents acryloyl, methacryloyl or hydroxymethylacryloyl.

US Pat. No. 9,382,520

MUTATED GENES FOR THE CATALYTIC PROTEIN OF OPLOPHORUS LUCIFERASE AND USE THEREOF

JNC CORPORATION, Tokyo (...

1. A recombinant polynucleotide comprising a gene encoding a luciferase mutant having a luciferase activity, wherein said
luciferase mutant is selected from the group consisting of:
(a) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2;

(b) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ. ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 is an amino acid sequence in which 1 to 17 amino acids are deleted, substituted, inserted
and/or added in the amino acid sequence at the positions of 5 to 169 of SEQ ID NO: 2; and

(c) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 has at least 90% identity to the amino acid sequence at the positions of 5 to 169 of SEQ
ID NO: 2.

US Pat. No. 9,365,774

LIQUID CRYSTAL COMPOUND HAVING CF2OCF3 AT TERMINAL, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in formula (1),
R1 is hydrogen, halogen or alkyl having 1 to 20 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O— or —S—, at least one of —(CH2)2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by halogen;

ring A1, ring A2, ring A3, ring A4 and ring A5 are independently 1,4-cyclohexylene, 1,4-phenylene, 1,4-phenylene in which at least one of hydrogen is replaced by halogen,
tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, pyrimidine-2,5-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl, naphthalene-2,6-diyl,
naphthalene-2,6-diyl in which at least one of hydrogen is replaced by halogen, or pyridine-2,5-diyl;

Z1, Z2, Z3 and Z4 are independently a single bond, —(CH2)2—, —CH?CH—, —CF?CF—, —C?C—, —COO—, —OCO—, —CF2O—, —OCF2—, —CH2O—, —OCH2—, —(CH2)4—, —(CH2)2CF2O—, —(CH2)2OCF2—, —CF2O(CH2)2—, —OCF2(CH2)2—, —CH?CH—(CH2)2— or —(CH2)2—CH?CH—; and

a, b, c and d are independently 0 or 1, and a sum of a, b, c and d is one or more
wherein Y is —CF2OCF3
wherein the compound of formula 1 has a dielectric anisotropy value that is at least 2.0 greater than a dielectric anisotropy
of the same compound where Y is —F.

US Pat. No. 9,315,603

POLYMERIZABLE COMPOUND HAVING OXYGEN-CONTAINING FIVE-MEMBERED RING, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in formula (1),
P1 and P2 are independently a polymerizable group;

S1 and S2 are independently a single bond or alkylene having 1 to 6 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —COO—, —OCO—, —CH?CH— or —C?C—; wherein both G are —CH? or —N?, wherein when one G is —CH?, the
other G is —CH?, and wherein one G is —N?, the other G is —N?;

wherein when both G are —CH?, ring A1, ring A2 and ring A3 are independently cyclohexylene, cyclohexenylene, phenylene, naphthylene, anthracenylene, tetrahydropyranylene, dioxanylene,
pyrimidinylene or pyridinylene, and in the groups, at least one of hydrogen may be replaced by halogen, alkyl having 1 to
12 carbons, alkoxy having 1 to 12 carbons, alkyl having 1 to 12 carbons in which at least one of hydrogen is replaced by halogen,
or alkoxy having 1 to 12 carbons in which at least one of hydrogen is replaced by halogen, one or two of hydrogen may be replaced
by —S3—P3, P3 is defined herein in a manner identical with the definition of P1 or P2, and S3 is defined in a manner identical with the definition of S1 or S2;

wherein when both G are —N?, ring A1, ring A2 and ring A3 are independently cyclohexylene, cyclohexenylene, phenylene, naphthylene, anthracenylene, tetrahydropyranylene, or dioxanylene,
and in the groups, at least one of hydrogen may be replaced by halogen, alkyl having 1 to 12 carbons, alkoxy having 1 to 12
carbons, alkyl having 1 to 12 carbons in which at least one of hydrogen is replaced by halogen, or alkoxy having 1 to 12 carbons
in which at least one of hydrogen is replaced by halogen, one or two of hydrogen may be replaced by —S3—P3, P3 is defined herein in a manner identical with the definition of P1 or P2, and S3 is defined in a manner identical with the definition of S1 or S2;

wherein when both G are —CH?, Z1, Z2 and Z3 are independently a single bond, —COO—, —OCO—, —CH?CH—, —CH?CH—COO—, —OCO—CH?CH—, —C(CH3)?CH—COO—, —OCO—CH?C(CH3)—, —CH?C(CH3)—COO—, —OCO—C(CH3)?CH—, —C(CH3)?C(CH3)—COO—, —OCO—C(CH3)?C(CH3)—, —C?C—, —COCH?CH—, —CH?CHCO—, —C(CH3)?C(CH3)—, —CH?CH—CH2O—, —OCH2—CH?CH—, —CH?CH—OCH2—, —CH2O—CH?CH— or —CO—;

wherein when both G are —N?, Z1 is a single bond, —COO—, —OCO—, —CH?CH—, —CH?CH—COO—, —OCO—CH?CH—, —C(CH3)?CH—COO—, —OCO—CH?C(CH3)—, —CH?C(CH3)—COO—, —OCO—C(CH3)?CH—, —C(CH3)?C(CH3)—COO—, —OCO—C(CH3)?C(CH3)—, —C?C—, —COCH?CH—, —CH?CHCO—, —C(CH3)?C(CH3)—, —CH?CH—CH2O—, —OCH2—CH?CH—, —CH?CH—OCH2—, —CH2O—CH?CH—, or —CO—; Z2 is a single bond, —COO—, —OCO—, —CH?CH—COO—, —C(CH3)?CH—COO—, —CH?C(CH3)—COO—, —C(CH3)?C(CH3)—COO—, —C?C—, —CH?CHCO—, —CH?CH—CH2O—, —CH?CH—OCH2—, or —CO—; Z3 is a single bond, —COO—, —OCO—, —OCO—CH?CH—, —OCO—CH?C(CH3)—, —OCO—C(CH3)?CH—, —OCO—C(CH3)?C(CH3)—, —C?C—, —COCH?CH—, —OCH2—CH?CH—, —CH2O—CH?CH—, or —CO—; and a is 0 or 1.

US Pat. No. 9,139,773

COMPOUND HAVING 3,3,3-TRIFLUORO-1-PROPENYLOXY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in formula (1),
R1 is alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, and at least one of —CH2CH2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by halogen;

ring A1 and ring A2 are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, 1,4-phenylene in which at least one of hydrogen is
replaced by halogen, tetrahydropyran-2,5-diyl, pyrimidine-2,5-diyl, pyridine-2,5-diyl, 1,3-dioxane-2,5-diyl or 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl;

Z1 and Z2 are independently a single bond, —CH2CH2—, —C?C—, —CH?CH—, —CF2O—, —CH2O— or —COO—, and at least one Z1 and Z2 is —CF2O—;

L1 and L2 are independently hydrogen or halogen; and

a is 0, 1, 2 or 3.

US Pat. No. 9,090,825

CYCLOHEXENE-3,6-DIYL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein, in formula (1), Ra and Rb are independently hydrogen, halogen or alkyl having 1 to 10 carbons, and in the alkyl,
arbitrary —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, and arbitrary —(CH2)2— may be replaced by —CH?CH— or —C?C—; A1, A2, A3 and A4 are independently 1,4-cyclohexylene, 1,4-phenylene, cyclohexene-1,4-diyl, cyclohexene-3,6-diyl, decahydronaphthalene-2,6-diyl,
1,2,3,4-tetrahydronaphthalene-2,6-diyl or naphthalene-2,6-diyl, and in the rings, one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, and arbitrary —(CH2)2— may be replaced by —CH?CH—, and in the rings, arbitrary hydrogen may be replaced by halogen, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F; Z1, Z2, Z3 and Z4 are independently a single bond or alkylene having 1 to 4 carbons, and in the alkylene, arbitrary —CH2— may be replaced by —O—, —S— or —SiH2—, and arbitrary —(CH2)2— may be replaced by —CH?CH— or —C?C—; m, n, q and r are independently 0, 1 or 2, and a sum of m, n, q and r is 1, 2, 3 or
4; and when a sum of m, n, q and r is 1, Ra and Rb are independently hydrogen, halogen or alkyl having 1 to 10 carbons, and
in the alkyl, arbitrary —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, and arbitrary —(CH2)2—may be replaced by —CH?CH— or —C?C—; A1, A2, A3 and A4 are independently 1,4-cyclohexylene, 1,4-phenylene in which one or more of hydrogen is replaced by halogen, cyclohexene-1,4-diyl,
cyclohexene-3,6-diyl, decahydronaphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl or naphthalene-2,6-diyl, and in
the rings, one of —CH2— may be replaced by —O—, —S—, —CO—, or —SiH2—, and arbitrary —(CH2)2— may be replaced by —CH?CH—, and in the rings, arbitrary hydrogen may be replaced by halogen, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F; and Z1, Z2, Z3 and Z4 are independently a single bond or alkylene having 1 to 4 carbons, and in the alkylene, arbitrary —CH2— may be replaced by —O—, —S— or —SiH2—, and arbitrary —(CH2)2— may be replaced by —CH?CH— or —C?C—.

US Pat. No. 9,512,360

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a positive dielectric anisotropy and contains at least one compound selected from
the group consisting of compounds represented by formula (1) as a first component, and at least one compound selected from
the group consisting of compounds represented by formula (2) as a second component:

wherein, in formula (1), R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkyl having
1 to 12 carbons in which at least one hydrogen is replaced by halogen, or alkenyl having 2 to 12 carbons in which at least
one hydrogen is replaced by halogen; ring A, ring B and ring C are independently 1,4-phenylene, or 1,4-phenylene in which
at least one hydrogen is replaced by fluorine or chlorine, and

in formula (2), R3 is alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons; ring D is 1,4-cyclohexylene,
1,4-phenylene, 2-fluoro-1,4-phenylene, 2,3 -difluoro-1,4-phenylene, 2,6-difluoro-1,4-phenylene, pyrimidine-2,5-diyl, 1,3-dioxane-2,5-diyl
or tetrahydropyran-2,5-diyl; Z1 is a single bond, ethylene, carbonyloxy or difluoromethyleneoxy; X1 and X2 are independently hydrogen or fluorine; Y1 is fluorine, chlorine, alkyl having 1 to 12 carbons in which at least one hydrogen is replaced by halogen, alkoxy having 1
to 12 carbons in which at least one hydrogen is replaced by halogen, or alkenyloxy having 2 to 12 carbons in which at least
one hydrogen is replaced by halogen; and p is 1, 2, 3 or 4.

US Pat. No. 9,446,382

POROUS CELLULOSE GEL, METHOD FOR PRODUCING THE SAME, AND USE THEREOF

JNC CORPORATION, Tokyo (...

1. A porous cellulose gel comprising crosslinked spherical crystalline cellulose particles having a solvent contained therein,
upon filling the gel in a chromatography column having an inner diameter of 2.2 cm to a height of 17.5±2.5 cm, a linear velocity
of water at 20° C. being from 2,400 to 4,500 cm/hour at a pressure of 0.4 MPa,
wherein the crosslinked spherical crystalline cellulose particles have a sphericity of from approximately 0.8 to approximately
1.0 and a particle diameter of from 1 to 2,000 ?m,

wherein the porous cellulose gel has an exclusion limit molecular weight with polyethylene glycol of from 1,000,000 to 5,000,000,
and

wherein the crosslinked spherical crystalline cellulose particles have a swelling degree of from 5 to 20 mL/g.

US Pat. No. 9,388,259

PHOTOSENSITIVE POLYMER AND PHOTOALIGNABLE PHASE DIFFERENCE FILM

JNC CORPORATION, Tokyo (...

1. A photosensitive polymer, comprising a constitutional unit having a photosensitive group as represented by formula (1),
and a constitutional unit having a hydrogen-bondable group at a terminal as represented by formula (2):

wherein, in formula (1), R1 is independently hydrogen or methyl; a is 2 or 3; p is independently an integer from 1 to 12; X1 is independently —O—, —COO— or —OCO—; b is an integer from 0 to 3; A1 is independently any one of divalent group selected from 1,4-phenylene, 1,4-cyclohexylene, pyridine-2,5-diyl or naphthalene-2,6-diyl,
and in the divalent group, at least one of hydrogen may be replaced by fluorine, chlorine, cyano, hydroxy, formyl, acetoxy,
acetyl, trifluoroacetyl, difluoromethyl, trifluoromethyl, alkyl having 1 to 5 carbons or alkoxy having 1 to 5 carbons; Z1 is independently a single bond, —O—, —COO—, —OCO—, —CH?CH—COO—, —CH2CH2—COO—, —CH2O—, —OCH2—, —CF2O—, —OCF2—, or —CONH—, —NHCO—, —(CH2)4—, —CH2CH2—, —CH?CH— or —C?C—; W1 and W2 are independently hydrogen, fluorine, chlorine, trifluoromethyl, alkyl having 1 to 5 carbons or alkoxy having 1 to 5 carbons;
Y1 is a single bond, —O— or —NH—; and R2 is alkyl having 1 to 20 carbons, and at least one of —CH2— in the alkyl may be replaced by —O—, —COO—, —OCO—, —CH?CH— or —C?C—:


wherein, in formula (2), R3 is hydrogen or methyl; Q is a single bond or alkylene having 1 to 20 carbons, and at least one of —CH2— in the alkylene may be replaced by —O—, —COO—, —OCO—, —CH?CH— or —C?C—; X2 is a single bond, —O—, —COO—, —OCO—, —OCOO—, —CH?CH— or —C?C—; A2 is independently any one of divalent group selected from 1,4-phenylene, 1,4-cyclohexylene, pyridine-2,5-diyl or naphthalene-2,6-diyl,
and in the divalent group, arbitrary hydrogen may be replaced by fluorine, chlorine, cyano, hydroxy, formyl, acetoxy, acetyl,
trifluoroacetyl, difluoromethyl, trifluoromethyl, alkyl having 1 to 5 carbons or alkoxy having 1 to 5 carbons; Z2 is independently a single bond, —O—, —COO—, —OCO—, —CH?CH—COO—, —CH2CH2—COO—, —CH2O—, —OCH2—, —CF2O—, —OCF2—, —CONH—, —NHCO—, —(CH2)4—, —CH2CH2—, —CH?CH— or —C?C—; c is an integer from 0 to 2; and Y2 is a single bond, —CH2CH2— or —CH?CH—.

US Pat. No. 9,290,868

BIODEGRADABLE NONWOVEN FABRIC AND FIBER PRODUCT USING THE SAME

JNC Corporation, Tokyo (...

1. A biodegradable nonwoven fabric, which is a mixed fiber nonwoven fabric comprising at least two kinds of fibers that are
mixed including a fiber A and a fiber B,
wherein the fiber A contains a first component having biodegradability,
wherein the fiber B contains a second component having biodegradability, wherein:
(a) the biodegradable nonwoven fabric comprises a mixed fiber web having a mixing ratio (weight ratio) of the fiber A and
the fiber B in a range of from 20/80 to 80/20,

(b) the first component comprises at least one member selected from the group consisting of an aliphatic polyester and an
aliphatic polyester copolymer each having a melting point that is higher than a melting point of the second component, and

(c) a half crystallization time at 85° C. of the second component is 180 seconds or more,
a half crystallization time at 85° C. of the first component is 60 seconds or less, and
the half crystallization time at 85° C. of the second component is longer than the half crystallization time at 85°°C. of
the first component by 80 seconds or more, and

wherein the tensile strength of the biodegradable nonwoven fabric is between 2.1 and 3.0 N per 25 mm.

US Pat. No. 9,099,654

BENZOFLUORENE COMPOUND, EMISSION MATERIALS AND ORGANIC ELECTROLUMINESCENT DEVICE

JNC CORPORATION, Tokyo (...

1. A benzofluorene compound represented by the following Formula (1):

wherein Ar1 and Ar2 are aryl which may be substituted;

R1 and R2 each are independently hydrogen, alkyl which may be substituted, cycloalkyl which may be substituted or aryl which may be
substituted, and at least one of R1 and R2 is aryl which may be substituted; and

the substituents in Ar1, Ar2, R1 and R2 each are independently selected from the group consisting of alkyl having 1 to 24 carbon atoms, cycloalkyl having 3 to 12
carbon atoms and aryl having 6 to 30 carbon atoms.

US Pat. No. 9,085,758

METHOD OF CULTURING VASCULAR SMOOTH MUSCLE CELLS, CULTURE DEVICE AND MEDICAL MATERIAL OBTAINED BY THE CULTURE

JNC CORPORATION, Tokyo (...

1. A method of proliferating vascular smooth muscle cells, comprising the steps of:
(i) culturing a mixture of vascular smooth muscle cells and other vascular cells on a substrate comprising elastin under a
static condition in which the elastin and substrate neither expands nor contracts,

(ii) after the mixture of cells has become bound to the elastin, culturing the mixture of cells under a dynamic condition
in which the elastin and substrate expands and contracts, and

(iii) selecting for proliferated vascular smooth muscle cells,
wherein the vascular smooth muscle cells are selectively proliferated more than the other vascular cells in the mixture.
US Pat. No. 9,593,240

THERMOSETTING RESIN COMPOSITION

JNC CORPORATION, Tokyo (...

1. A thermosetting resin composition containing (A) to (D) below:
(A) a thermosetting resin containing an SiH group and an alkenyl group, the thermosetting resin being a reaction product between
silsesquioxane having the SiH group and organopolysiloxane having two alkenyl groups;

(B) a thermosetting resin having an SiH group obtained by allowing reaction among silsesquioxane having an SiH group, organopolysiloxane
having two alkenyl groups, an epoxy compound having an alkenyl group and a silyl compound having an alkenyl group;

(C) a linear organopolysiloxane compound having an SiH group only at one terminal; and
(D) a Pt catalyst.

US Pat. No. 9,574,224

MUTATED GENES FOR THE CATALYTIC PROTEIN OF OPLOPHORUS LUCIFERASE AND USE THEREOF

JNC CORPORATION, Tokyo (...

1. A method for performing a luminescence reaction, which comprises contacting a luciferase mutant with a luciferin, wherein
the luciferase mutant is selected from (a) to (e) below:
(a) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2;

(b) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 is an amino acid sequence in which 1 to 17 amino acids are deleted, substituted, inserted
and/or added in the amino acid sequence at the positions of 5 to 169 of SEQ ID NO: 2, and having a luciferase activity;

(c) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 has at least 90% identity to the amino acid sequence at the positions of 5 to 169 of SEQ
ID NO: 2, and having a luciferase activity;

(d) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 is encoded by a polynucleotide which hybridizes under high stringent conditions to a polynucleotide
consisting of a nucleotide sequence complementary to a nucleotide sequence encoding the amino acid sequence at the positions
of 5 to 169 of SEQ ID NO: 2, wherein the high stringent conditions are 5×SSC, 5×Denhart's solution, 0.5% (w/v) SDS, 50% (v/v)
formamide and 50° C., and having a luciferase activity; and,

(e) a luciferase mutant consisting of an amino acid sequence selected from SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8 and SEQ
ID NO: 10.

US Pat. No. 9,567,623

COELENTERAZINE ANALOGS

JNC CORPORATION, Tokyo (...

1. A compound represented by general formula (1) below:

wherein in said general formula (1), R1 is hydrogen, a substituted or unsubstituted aryl a substituted or unsubstituted arylalkyl, a substituted or unsubstituted
arylalkenyl, an alkyl which may optionally be substituted with an alicyclic group, an alkenyl which may optionally be substituted
with an alicyclic group, an alicyclic group, or a heterocyclic group.

US Pat. No. 9,512,273

THERMOSETTING RESIN COMPOSITION

JNC CORPORATION, Tokyo (...

1. A thermosetting resin composition containing (A) to (D) below:
(A) a thermosetting resin containing an SiH group and an alkenyl group, wherein the thermosetting resin is a reaction product
between silsesquioxane having the SiH group and organopolysiloxane having two alkenyl groups;

(B) a linear organopolysiloxane compound having an SiH group only at one terminal;
(C) a silane coupling agent having an epoxy group; and
(D) a Pt catalyst,
wherein the silsesquioxane is double decker silsesquioxane.

US Pat. No. 9,505,980

POLYMERIZABLE LIQUID CRYSTAL COMPOSITION AND OPTICALLY ANISOTROPIC SUBSTANCE HAVING TWIST ALIGNMENT

JNC CORPORATION, Tokyo (...

1. A polymerizable liquid crystal composition, containing an optically active compound having a binaphthol moiety, an achiral
polymerizable liquid crystal compound and a photopolymerization initiator (C) having oxime ester,
wherein an absorption maximum wavelength of a mixture including the achiral polymerizable liquid crystal compound and the
optically active compound having the binaphthol moiety is in the range of 220 to 400 nanometers, and the absorption maximum
wavelength is different from an absorption maximum wavelength of the photopolymerization initiator having oxime ester by 50
nanometers or more, and

wherein the achiral polymerizable liquid crystal compound is component (A) being at least one compound represented by formula
(1-1), and the optically active compound having the binaphthol moiety is component (B) being at least one compound represented
by formula (2-2):


wherein, in formula (1-1),
X? is independently hydrogen, methyl, fluorine or trifluoromethyl;
W11 is independently hydrogen or methyl;

W12 is independently hydrogen, halogen, nitro, cyano, alkyl having 1 to 7 carbons or alkoxy having 1 to 7 carbons; and

n11 is independently an integer from 2 to 10;

in formula (2-2),
Y2 is independently a group represented by formula (2-1);

in formula (2-1),
R1 is independently halogen, cyano, alkenyl having 2 to 20 carbons or alkyl having 1 to 20 carbons, at least one of —CH2— in the group may be replaced by —O—, excluding a case where —O— is adjacent, at least one of hydrogen in the group may be
replaced by halogen, and one of hydrogen in the group may be replaced by acryloyloxy, methacryloyloxy or trifluoromethylacryloyloxy;

A2 is independently 1,4-cyclohexylene, 1,4-phenylene, 4,4?-biphenylene, naphthalene-2,6-diyl, decahydronaphthalene-2,6-diyl,
1,2,3,4-tetrahydronaphthalene-2,6-diyl, or 1,4-phenylene in which at least one of hydrogen is replaced by halogen;

Z1 is independently a single bond, —O—, —COO—, —OCO—, —OCF2— or —(CH2)p—, and one of —CH2— in —(CH2)p— may be replaced by —O—;

p is independently an integer from 1 to 20; and
r is independently an integer from 1 to 3.

US Pat. No. 9,499,745

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a positive dielectric anisotropy and contains at least one compound represented by
formula (1) as a first component and at least one compound represented by formula (2) as a second component:

wherein, R1 is alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons; R2 is propyl; R3 is hydrogen; X1, X2, X3 and X4 are independently hydrogen or fluorine; and Y1 is fluorine, chlorine, trifluoromethyl or trifluoromethoxy.

US Pat. No. 9,481,954

PROCESSING APPARATUS FOR HOT-AIR TREATMENT OF FIBER CONSTITUTING NONWOVEN FABRIC TO PRODUCE NONWOVEN FABRIC, AND PROCESSING PROCESS FOR THE SAME

JNC FIBERS CORPORATION, ...

1. A processing apparatus for hot-air treatment of nonwoven fabric, comprising:
a rotating running endless belt provided with a plurality of holes;
a hot-air blowing apparatus for blowing hot air from an internal side of the endless belt with holes toward an outer side
thereof;

an endless belt for fiber conveyance arranged so as to oppose the outer side of the endless belt with holes,
wherein the endless belt for fiber conveyance is positioned opposite the hot-air blowing apparatus and the endless belt for
fiber conveyance is rotatable while at a hot-air treatment part so that hot-air from the hot-air blowing apparatus passes
therethrough to form spots in the fiber web; and

a cooling-air sucking system without an air-forcibly cooling apparatus and including a cooling-air sucking duct located at
a position immediately near a downstream part of the hot-air treatment part and at an internal side of the endless belt for
fiber conveyance such that atmospheric air penetrates through the endless belt with holes due to suction provided by the cooling-air
sucking duct,

wherein heat-bonded parts are formed at the spots in the fiber web, and the heat-bonded parts correspond to the holes in the
endless belt with holes,

wherein the endless belt with holes and the endless belt for fiber conveyance are spaced at a distance that is freely controllable
in a range of 0.1 to 20 mm, and

wherein a percentage of open area formed by the holes in the endless belt with holes relative to the total area of the endless
belt with holes is 60% or less.

US Pat. No. 9,453,105

EPOXY AND ALKOXYSILYL GROUP-CONTAINING SILSESQUIOXANE AND COMPOSITION THEREOF

JNC CORPORATION, Tokyo (...

1. A silicon compound obtained by a hydrosilylation reaction of a compound (a), a compound (b) and a compound (c), wherein
the compound (a) is at least one compound selected from the group consisting of compounds represented by formulae (a-1) to
(a-5),

the compound (b) is at least one compound selected from the group consisting of compounds represented by formulae (b-1) to
(b-5), and

the compound (c) is a compound represented by formula (c-1):
wherein in formulae (a-1) to (a-5),
each R is a group independently selected from an alkyl having a carbon number of 1 to 45, a cycloalkyl having a carbon number
of 4 to 8, an aryl having a carbon number of 6 to 14, and an arylalkyl having a carbon number of 7 to 24; in the alkyl having
a carbon number of 1 to 45, at least one hydrogen may be replaced by fluorine, and at least one non-adjacent —CH2— may be replaced by —O— or —CH?CH—; in a benzene ring of the aryl and arylalkyl, at least one hydrogen may be replaced by
a halogen or an alkyl having a carbon number of 1 to 10, and in this alkyl having a carbon number of 1 to 10, at least one
hydrogen may be replaced by fluorine, and at least one non-adjacent —CH2— may be replaced by —O— or —CH?CH—; the carbon number of the alkylene in the arylalkyl is from 1 to 10, and at least one
non-adjacent —CH2— therein may be replaced by —O—;

each R1 is a group independently selected from an alkyl having a carbon number of 1 to 4, cyclopentyl, cyclohexyl and phenyl;

at least two X in one molecule of each compound are hydrogen, with the remaining being a group independently selected from
an alkyl having a carbon number of 1 to 4, cyclopentyl, cyclohexyl and phenyl;

in formulae (a-1) and (a-3) to (a-5),
each R2 is a group independently selected from an alkyl having a carbon number of 1 to 4, cyclopentyl, cyclohexyl and phenyl;

in formulae (a-4) and (a-5),
n is an integer of 1 to 100;
wherein in formulae (b-1) to (b-3) and (b-5), either one of R3 and R4 is an alkenyl having a carbon number of 2 to 10 in which one —CH2— may be replaced by —O— or 1,4-phenylene, and the other is hydrogen or an alkyl having a carbon number of 1 to 6; and
R5—Si(OR6)3  (c-1)
wherein in formula (c-1), R5 is an alkenyl having a carbon number of 2 to 10, one —CH2— in this alkenyl may be replaced by —O— or 1,4-phenylene, and R6 is an alkyl having a carbon number of 1 to 6 or hydrogen.

US Pat. No. 9,439,813

FUNCTIONAL SHEET

JNC CORPORATION, Tokyo (...

1. A functional sheet, comprising a sheet containing at least one fibrous layer, wherein the sheet is obtained by masking
and pressing a surface of the at least one fibrous layer using a planar object having a plurality of openings, wherein convexes
are formed in parts of the at least one fibrous layer which are exposed to the plurality of openings of the planar object
and plains are formed in parts of the at least one fibrous layer onto which the planar object is pressed, applying a solution
of a modifier from a side of the planar object to allow the modifier to deposit onto whole surfaces of the convexes of the
sheet and then removing the planar object, wherein portions of the at least one fibrous layer where the modifier was deposited
are the convexes and portions of the at least one fibrous layer where no modifier was deposited are the plains, an area of
each opening of the plurality of openings of the planar object is in the range of approximately 1.5 mm2 to approximately 20 mm2, and the modifier comprises a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, a hyaluronic acid, or a collagen.
US Pat. No. 9,404,145

CODON-OPTIMIZED GENE FOR MUTATED SHRIMP LUCIFERASE AND METHOD FOR USE THEREOF

JNC CORPORATION, Tokyo (...

1. A method for determining the activity of a sequence associated with promoter control, which comprises using as a reporter
gene a polynucleotide selected from the group consisting of (a) to (d) below:
(a) a polynucleotide comprising a polynucleotide consisting of the nucleotide sequence of SEQ ID NO: 2;
(b) a polynucleotide comprising a polynucleotide encoding a protein consisting of a nucleotide sequence in which 1 to 20 nucleotides
are deleted, substituted, inserted and/or added in the nucleotide sequence of SEQ ID NO: 2, and having a luminescent catalyst
activity by using luciferin as a substrate;

(c) a polynucleotide comprising a polynucleotide encoding a protein consisting of a nucleotide sequence having at least 90%
identity to the nucleotide sequence of SEQ ID NO: 2, and having a luminescent catalyst activity by using luciferin as a substrate;
and,

(d) a polynucleotide comprising a polynucleotide encoding a protein which hybridizes to a polynucleotide consisting of a nucleotide
sequence complementary to the nucleotide sequence of SEQ ID NO: 2 under high stringency conditions, and has a luminescent
catalyst activity by using luciferin as a substrate, wherein the high stringency conditions are 5×SSC, 5×Denhardt's solution,
0.5% (w/v) SDS, 50% (v/v) formamide, and 50° C.

US Pat. No. 9,315,728

POLYMERIZABLE LIQUID CRYSTAL COMPOSITION AND HOMOGENEOUS-ALIGNED LIQUID CRYSTAL FILM

JNC CORPORATION, Tokyo (...

1. A polymerizable liquid crystal composition comprising a mixture of polymerizable compounds containing at least one compound
selected from a group of compounds represented by the formula (1-1) as a component A, at least one compound selected from
a group of compounds represented by the formula (2-1) as a component B, at least one compound selected from a group of compounds
represented by the formulae (3-2) and (3-3) as a component C and optionally at least one compound selected from a group of
compounds represented by the formula (4-1) as a component D, and at least a nonionic surfactant as a component E, wherein
a birefringence (?n) of a liquid crystal film obtained by polymerizing the polymerizable liquid crystal composition is in
a range of 0.10 to 0.13:
wherein
in the formula (1-1),
ring T represents triptycen-1,4-diyl; Z1 independently represents hydrogen, fluorine, chlorine, methyl or trifluoromethyl; W1 independently represents hydrogen, halogen, alkyl having from 1 to 3 carbon atoms or fluoroalkyl having from 1 to 3 carbon
atoms; Y1 independently represents a single bond, —COO—, —OCO—, —CH?CH—COO—, —OCO—CH?CH—, —(CH2)2—COO— or —OCO—(CH2)2—; and n1 independently represents an integer of from 2 to 15,

in the formula (2-1),
Z2 independently represents hydrogen, fluorine, methyl or trifluoromethyl; W2 independently represents hydrogen, halogen, alkyl having from 1 to 3 carbon atoms or fluoroalkyl having from 1 to 3 carbon
atoms; Y2 independently represents a single bond, —CH?CH— or —(CH2)2—; and n2 independently represents an integer of from 2 to 15,

in the formulae (3-2) and (3-3),
Z3 independently represents hydrogen, fluorine, methyl or trifluoromethyl; W3 independently represents hydrogen, halogen, alkyl having from 1 to 3 carbon atoms or fluoroalkyl having from 1 to 3 carbon
atoms; W32 independently represents hydrogen, halogen, alkyl having from 1 to 8 carbon atoms or fluoroalkyl having from 1 to 8 carbon
atoms; ring A3 independently represents 1,4-phenylene or 1,4-cyclohexylene; X3 independently represents a single bond, —COO—, —OCO—, —CH?CH—COO—, —OCO—CH?CH—, —(CH2)2—COO—, —OCO—(CH2)2—, —(CH2)2—, —C?C—, —CH2O— or —OCH2—; Y3 independently represents a single bond, alkylene having from 1 to 20 carbon atoms, —O—, —COO—, —OCO— or —OCOO—; r represents
0 or 1; and n3 independently represents an integer of from 0 to 20, provided that when n3 is 0, Y3 represents a single bond or alkylene having from 1 to 20 carbon atoms,

in the formula (4-1),
Z4 represents hydrogen, fluorine, methyl or trifluoromethyl; W4 independently represents hydrogen, halogen, alkyl having from 1 to 3 carbon atoms or fluoroalkyl having from 1 to 3 carbon
atoms; X4 represents a single bond, —O—, alkylene having from 1 to 20 carbon atoms, —COO— or —OCO—; ring A4 independently represents 1,4-phenylene or 1,4-cyclohexylene; R4 represents hydrogen, fluorine, chlorine, cyano, alkyl having from 1 to 20 carbon atoms or alkoxy having from 1 to 20 carbon
atoms, in which in the alkyl and the alkoxy, arbitrary hydrogen may be replaced by halogen; n4 represents an integer of from
0 to 20; and p and q each independently represent 0 or 1, provided that when n4 is 0, X4 represents a single bond or alkylene having from 1 to 20 carbon atoms, and

in the formula (2-1),
A2 represents a divalent group represented by one of the formulae (A2-10), (A2-11) and (A2-16)


US Pat. No. 9,073,850

POLYMERIZABLE COMPOUND

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1-1) or (1-2), wherein
in formula (1-1),
Z3 is alkylene having 1 to 7 carbons, and at least one —CH2— in the alkylene has been replaced by —CH?CH—O—;

Y1 to Y8 are independently hydrogen, fluorine, methyl or trifluoromethyl;

X1 is hydrogen, fluorine, methyl or trifluoromethyl; and

P1 is a polymerizable group selected from groups represented by formula (P-1) to formula (P-3),

in formula (1-2),
Z3 is alkylene having 1 to 7 carbons, and at least one-CH2— in the alkylene has been replaced by —CH?CH—O—;

L1 to L12 are independently hydrogen, fluorine, methyl or trifluoromethyl;

X1 is hydrogen, fluorine, methyl or trifluoromethyl; and

P1 is a polymerizable group selected from groups represented by formula (P-1) to formula (P-3).

US Pat. No. 9,062,250

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy and contains at least one compound selected from
the group of compounds represented by formula (1) as a first component, at least one compound selected from the group of compounds
represented by formula (2) as a second component:

wherein R1 is independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, or alkenyl having 2 to 12 carbons; R2 and R3 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons; ring A and
ring B are independently;


X1 and X2 are independently fluorine or chlorine;

Y1 is independently hydrogen or methyl; Z1 and Z2 are independently a single bond, ethylene, methyleneoxy, or carbonyloxy; m and n are independently 0, 1, 2, or 3, and the
sum of m and n is 1, 2, or 3.

US Pat. No. 9,056,840

COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES

JNC CORPORATION, Tokyo (...

1. A compound represented by general formula (III) below:
wherein Z1 is O or S; and R3? is hydrogen atom, bromine atom, a substituted or unsubstituted aryl, a substituted or unsubstituted arylalkyl, a substituted
or unsubstituted arylalkenyl, a substituted or unsubstituted arylalkynyl, an alkyl which may optionally be substituted with
an alicyclic group, an alkenyl which may optionally be substituted with an alicyclic group, an alkynyl which may optionally
be substituted with an alicyclic group, an alicyclic group, or a heterocyclic group.

US Pat. No. 9,648,938

COSMETIC TOOL, RETAINER OF COSMETIC MATERIAL AND METHOD OF MANUFACTURING COSMETIC TOOL

JNC CORPORATION, Tokyo (...

1. A method of manufacturing a cosmetic tool, comprising:
proving a retainer having: a frame of a thickness of approximately 1 mm that forms an aperture; and a handle for holding the
frame;

immersing the frame in aqueous solution of skin care ingredients so as to impregnate the aqueous solution in the frame; and
freeze-drying the aqueous solution while the frame is immersed therein such that the aqueous solution forms a cosmetic material
that closes the aperture of the frame.

US Pat. No. 9,605,207

ORTHOESTER DERIVATIVE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition containing a first component and a second component, wherein the first component is at least
one compound selected from the compounds represented by formula (1):

wherein, in the formula, R1 is alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, at least one of —(CH2)2— may be replaced by —CH?CH—, and at least one of hydrogen may be replaced by halogen; ring A1, ring A2, ring A3, ring A4, ring A5 and ring A6 are independently 1,4-cyclohexylene or 1,4-phenylene, at least one of —CH2— in the 1,4-cyclohexylene may be replaced by —O—, at least one of —(CH2)2— in the 1,4-cyclohexylene may be replaced by —CH?CH—, at least one of —CH? in the 1,4-phenylene may be replaced by —N?, and
at least one of hydrogen in the 1,4-phenylene may be replaced by halogen; Z1, Z2, Z3, Z4, Z5, Z6 and Z7 are independently a single bond, —(CH2)2—, —COO—, —OCO—, —CF2O—, —OCF2— or —CH?CH—; X1 is fluorine, —CF3 or —OCF3; Y1 and Y2 are independently hydrogen or fluorine; i, j, k, n, p and q are independently 0 or 1; and a sum of i, j, k, m, n, p and q
is 2, 3 or 4.

US Pat. No. 9,590,182

BENZOFLUORENE COMPOUND, MATERIAL FOR LUMINESCENT LAYER USING SAID COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE

JNC CORPORATION, Tokyo (...

1. A benzofluorene compound represented by the following formula (1):

wherein
Ar is each independently phenyl, naphthyl or a heteroaryl,
R1 is each independently, an aryl, a cycloalkyl, fluorine, cyano, an alkyl substituted by fluorine, an alkoxy optionally substituted
by fluorine, a substituted silyl or a substituted germyl,

R2 is each independently, an aryl, fluorine, cyano, an alkyl substituted by fluorine, an alkoxy optionally substituted by fluorine,
a substituted silyl or a substituted germyl,

n1 and n2 are each independently an integer of 0 to 5, and in the case when one naphthyl group is substituted with two or
more adjacent R1s or in the case when one Ar group is substituted with two or more adjacent R2s, these may bind to form an aliphatic ring,

R3 is each independently an alkyl or an aryl, wherein two Ras may bind to each other to form a ring, and

at least one hydrogen in the compound represented by the formula (1) may be substituted with deuterium.

US Pat. No. 9,527,870

LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1-1):

wherein, in formula (1-1),
R is hydrogen or alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O— or —S—, at least one of —(CH2)2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by halogen;

ring A1, ring A2 and ring A3 are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl,
pyrimidine-2,5-diyl, pyridine-2,5-diyl, naphthalene-2,6-diyl, decahydronaphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl,
1,4-phenylene, or 1,4-phenylene in which at least one of hydrogen is replaced by halogen;

W1 is a group represented by formula (1a) or formula (1b);


wherein, in formula (1a) and formula (1b),
Y1 and Y2 are independently hydrogen, chlorine or fluorine, Y3, Y4 and Y5 are independently hydrogen, fluorine or chlorine, and at least two of Y3, Y4 and Y5 is fluorine or chlorine; and

in formula (1-1),
W2 is a group represented by formula (1c) or formula (1d);


wherein, in formula (1c) and formula (1d),
L1, L2, L3, L4 and L5 are independently hydrogen, fluorine or chlorine; and

in formula (1-1),
X is halogen, —C?N, —N?C?S, —SF5, —CF3, —CF2H, —CFH2, —OCF3, —OCF2H, —OCFH2 or alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O— or —S—, at least one of —(CH2)2— may be replace by CH?CH—, and in the groups, at least one of hydrogen may be replaced by halogen; and

l, m and n are 0 or 1, and a sum of l, m and n is 0, 1 or 2;
in which, when a sum of l and m is 1 and n is 0, at least one of W1 and W2 is a group represented by formula (1b) or formula (1d), or at least one of l piece of ring A1 and m pieces of ring A2 is 1,4-cyclohexylene, 1,4-cyclohexenylene, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl,
pyrimidine-2,5-diyl, pyridine-2,5-diyl, naphthalene-2,6-diyl, decahydronaphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl,
or 1,4-phenylene in which at least one of hydrogen is replaced by halogen.

US Pat. No. 9,506,104

CODON-OPTIMIZED GENE FOR MUTATED SHRIMP LUCIFERASE AND METHOD FOR USE THEREOF

JNC CORPORATION, Tokyo (...

1. A method for performing a luminescence reaction, which comprises contacting a protein encoded by a polynucleotide selected
from the group consisting of (a) to (d) below:
(a) a polynucleotide comprising a polynucleotide consisting of the nucleotide sequence of SEQ ID NO: 2;
(b) a polynucleotide comprising a polynucleotide encoding a protein consisting of a nucleotide sequence in which 1 to 20 nucleotides
are deleted, substituted, inserted and/or added in the nucleotide sequence of SEQ ID NO: 2, and having a luminescent catalyst
activity by using luciferin as a substrate;

(c) a polynucleotide comprising a polynucleotide encoding a protein consisting of a nucleotide sequence having at least 90%
identity to the nucleotide sequence of SEQ ID NO: 2, and having a luminescent catalyst activity by using luciferin as a substrate;
and,

(d) a polynucleotide comprising a polynucleotide encoding a protein which hybridizes to a polynucleotide consisting of a nucleotide
sequence complementary to the nucleotide sequence of SEQ ID NO: 2 under high stringency conditions, and has a luminescent
catalyst activity by using luciferin as a substrate, wherein the high stringency conditions are 5×SSC, 5×Denhardt's solution,
0.5% (w/v) SDS, 50% (v/v) formamide, and 50° C.,

with bis-coelenterazine or h-coelenterazine.

US Pat. No. 9,458,125

OCTAHYDRO BINAPHTHYL-BASED CHIRAL COMPOUND-CONTAINING LIQUID-CRYSTAL COMPOSITION AND OPTICAL ELEMENT

JNC CORPORATION, Tokyo (...

1. A liquid-crystal composition, comprising at least one chiral compound represented by general formula (K1) or (K2) and at
least one achiral liquid-crystal component:

wherein, in formulas (K1) and (K2),
Rk1 is halogen, cyano, —SF5 or alkyl having 1 to 5 carbons, at least one of —CH2— in Rk1 may be replaced by —O—, and at least one of hydrogen in Rk1 may be replaced by halogen;

Rk2 is halogen, cyano, —SF5 or alkyl having 1 to 20 carbons, at least one of —CH2— in Rk2 may be replaced by —O—, and at least one of hydrogen in Rk2 may be replaced by halogen;

ring Ak1 is 1,4-phenylene, 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, tetrahydropyran-2,5-diyl, tetrahydropyran-3,5-diyl, pyrimidine-2,5-diyl,
pyridine-2,5-diyl or 1,4-bicyclo-(2,2,2)-octylene, and at least one of hydrogen in the rings may be replaced by halogen;

Xk1 is a single bond, —O—, —CO—, —COO—, —OCO—, —OCH2—, —CH2O—, —CF2O—, —OCF2—, —CH?CH—, —CF2CF2—, —CF?CF— or —C?C—;

Yk1 is a single bond or —(CH2)n—, and n is an integer from 1 to 20;

Zk1 is a single bond or alkylene having 1 to 10 carbons, at least one of —CH2— in Zk1 may be replaced by —O—, —COO—, —OCO—, —CH?CH—, —CF?CF— or —C?C—, and at least one of hydrogen in Zk1 may be replaced by halogen;

mk1 is an integer from 2 to 4; nk1 and nk2 is an integer from 0 to 2; andwhen a plurality of Rk1, Rk2, Ak1, Ak2, Xk1, Yk1, Zk1, mk1, nk1 or nk2 exist, the plurality may be identical or different each other.

US Pat. No. 9,434,883

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a positive dielectric anisotropy and a nematic phase, and contains at least one compound
selected from the group of compounds represented by formula (1) as an additive component and at least one compound from the
group of compounds represented by formula (2) as a first component:
wherein, in formula (1), R1 is hydrogen or alkyl having 1 to 15 carbons; R2, R3, R4 and R5 are independently hydrogen or alkyl having 1 to 4 carbons; ring A is a polyvalent group derived from benzene or cyclohexane
by eliminating hydrogen; a is 3 or 4; and
in formula (2), R6 is alkyl having 1 to 12 carbons, alkoxy having to 12 carbons or alkenyl having 2 to 12 carbons; ring B is 1,4-cyclohexylene,
1,4-phenylene, 2-fluoro-1,4-phenylene, 2,3-difluoro-1,4-phenylene, 2,6-difluoro-1,4-phenylene, pyrimidine-2,5-diyl, 1,3-dioxane-2,5-diyl
or tetrahydropyran-2,5-diyl; Z1 is a single bond, ethylene, carbonyloxy or difluoromethyleneoxy; X1 and X2 are independently hydrogen or fluorine; Y1 is fluorine, chlorine, alkyl having 1 to 12 carbons in which at least one of hydrogen is replaced by fluorine or chlorine,
alkoxy having 1 to 12 carbons in which at least one of hydrogen is replaced by fluorine or chlorine, or alkenyloxy having
2 to 12 carbons in which at least one of hydrogen is replaced by fluorine or chlorine; and b is 1, 2, 3 or 4.

US Pat. No. 9,395,366

NON-HEATING DETECTION METHOD FOR DERMATOPHYTE

NATIONAL UNIVERSITY CORPO...

1. A method of detecting dermatophyte, comprising the following steps:
(a) a step of extracting a dermatophyte component from a sample selected from group consisting of skin, nail, scale, hair
and pelage with a treatment liquid comprising 0.5-5.0 wt % of n-octyl-?-D-glucoside at a temperature of 4° C.-45° C.,

(b) a step of forming a complex by contacting the dermatophyte component obtained in said step (a) with an antibody produced
by hybridoma 0014, and

(c) a step of detecting the complex formed in said step (b).

US Pat. No. 9,382,479

LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a nematic phase and contains at least one compound selected from the group of compounds
represented by formula (1) as a first component and at least one compound selected from the group of compounds represented
by formula (2) as a second component simultaneously, the second component contains at least one compound selected from the
group of compounds represented by formula (2-1):

wherein R1 is alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons, and R2 and R3 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkenyl
having 2 to 12 carbons in which at least one hydrogen is replaced by fluorine; ring A and ring B are independently 1,4-cyclohexylene,
1,4-phenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene or 2,5-difluoro-1,4-phenylene; Z1 is independently a single bond, ethylene or carbonyloxy; X1, X2, X3 and X4 are independently hydrogen or fluorine; and m and n are independently 1, 2 or 3.

US Pat. No. 9,376,621

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition comprising at least one polymerizable compound represented by formula (1) and at least one
compound represented by formula (2) as a first component:


in formula (1), P1 and P2 are independently a polymerizable group selected from the group of groups represented by formula (P-1) to formula (P-3):


where in formula (P-1), M1, M2 and M3 are independently hydrogen, fluorine, alkyl having 1 to 5 carbons, or alkyl having 1 to 5 carbons in which at least one hydrogen
has been replaced by halogen, and in formula (P-3), M4 is hydrogen, methyl, ethyl or propyl; ring A is a bridged ring, and in the ring at least one hydrogen may be replaced by halogen
or alkyl having 1 to 12 carbons that may contain at least one halogen; ring B is a bridged ring, a cyclohexane ring, a cyclohexene
ring, a benzene ring or a naphthalene ring, and in these rings at least one hydrogen may be replaced by halogen or alkyl having
1 to 12 carbons that may contain at least one halogen; Z1 and Z3 are independently a single bond or alkylene having 1 to 10 carbons, and in the alkylene at least one —CH2— may be replaced by —O—, —COO—, —OCO— or —OCOO—, and at least one —CH2—CH2— may be replaced by —CH?CH— or —C ?C—; Z2 is a single bond, —COO—, —OCO— or —O—; a is 1, 2 or 3; b is 0, 1, 2 or 3; c is 1 or 2; and the sum of a and c is 2 to 4, and

in formula (2), R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkenyloxy
having 2 to 12 carbons; ring E and ring G are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, 1,4-phenylene
in which at least one hydrogen has been replaced by fluorine or chlorine, or tetrahydropyran-2,5-diyl; ring F is 2,3-difluoro-1,4-phenylene,
2-chloro-3-fluoro-1,4-phenylene, 2,3-difluoro-5-methyl-1,4-phenylene, 3,4,5-trifluoronaphthalene-2,6-diyl, or 7,8-difluorochroman-2,6-diyl;
Z5 and Z6 are independently a single bond, —CH2CH—, —CH2O—, —OCH2—, —COO— or —OCO—; e is 1, 2 or 3; f is 0 or 1; and the sum of e and f is 3 or less.

US Pat. No. 9,359,553

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition, having a negative dielectric anisotropy, and comprising at least one compound selected from
the group of compounds represented by formula (1) as a first component and at least one compound selected from the group of
compounds represented by formula (2) as a second component:

wherein
in formula (1), R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkyl having
1 to 12 carbons in which at least one hydrogen has been replaced by halogen, or alkenyl having 2 to 12 carbons in which at
least one hydrogen has been replaced by halogen; and ring A, ring B and ring C are independently 1,4-phenylene, or 1,4-phenylene
in which at least one hydrogen has been replaced by fluorine or chlorine, and

in formula (2), R3 and R4 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkenyloxy
having 2 to 12 carbons, or alkyl having 1 to 12 carbons in which at least one hydrogen has been replaced by halogen; ring
D and ring F are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, 1,4-phenylene in which at least one
hydrogen has been replaced by fluorine or chlorine, or tetrahydropyran-2,5-diyl; ring E is 2,3-difluoro-1,4-phenylene, 2-chloro-3-fluoro-1,4-phenylene,
2,3-difluoro-5-methyl-1,4-phenylene, 3,4,5-trifluoronaphthalene-2,6-diyl or 7,8-difluorochroman-2,6-diyl; Z1 and Z2 are independently a single bond, ethylene, carbonyloxy or methyleneoxy; a is 1, 2 or 3; b is 0 or 1; the sum of a and b is
3 or less; and when the sum of a and b is 2, and the a-numbering ring D and the b-numbering ring F are 1,4-phenylene, or 1,4-phenylene
in which at least one hydrogen has been replaced by fluorine or chlorine, Z1 and Z2 are independently a single bond, carbonyloxy or methyleneoxy.

US Pat. No. 9,346,775

METHOD FOR MANUFACTRURING ?-(METH)ACRYLOYLOXY-?-BUTYROLACTONES

JNC CORPORATION, Tokyo (...

1. A method for manufacturing a ?-(meth)acryloyloxy-?-butyrolactone compound represented by formula (2), wherein a methacrylate
compound as represented by formula (3) and a ketene compound represented by formula (4) are condensed to form a methacrylate
compound having the ?-propiolactone skeleton represented by formula (1), and the resulting methacrylate compound having the
?-propiolactone skeleton represented by formula (1) is isomerized to obtain the ?-methacryloyloxy-y-butyrolactone compound
represented by formula (2):


wherein forming the methacrylate compound having a ?-propiolactone skeleton as represented by formula (1) comprises:
dissolving the methacrylate compound as represented by formula (3) in an organic solvent to obtain a solution;
adding a catalyst in the solution, wherein the catalyst is diethyl ether complex of boron trifluoride;
passing the ketene compound represented by formula (4) to the solution and reacting at a temperature range of 0 to 50° C.
to obtain the methacrylate compound having a ?-propiolactone skeleton as represented by formula (1) in a reaction mixture;

washing the reaction mixture with a 10% sodium carbonate aqueous solution and saturated brine;
allowing the methacrylate compound having a ?-propiolactone skeleton as represented by formula (1) to undergo isomerization
through the help of the catalyst at a temperature range of 20 to 50° C.; and

removing the organic solvent, so as to obtain the ?-methacryloyloxy-?-butyrolactone compound represented by formula (2),
wherein, R1 is hydrogen or methyl, and R2, R3, R4, R5 and R6 are independently hydrogen or alkyl having 1 to 5 carbons.

US Pat. No. 9,139,672

POLYMERIZABLE COMPOUND, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, A1 and A3 are independently an aromatic ring group in which at least one of hydrogen may be replaced by L, or a heterocyclic aromatic
ring group in which at least one of hydrogen may be replaced by L; A2 is independently an aromatic ring group in which at least one of hydrogen may be replaced by L, a heterocyclic aromatic ring
group in which at least one of hydrogen may be replaced by L, or a single bond; Z1 is —CO—CR1?CR2—, —CR1?CR2—CO—, —CR1?CR2—, —C(?CR1R2)— or —C(?R3)—; Z2 is independently —CO—CR1?CR2—, —CR1?CR2—CO—, —CR1?CR2—, —C(?CR1R2)— or —C(?R3)—; R1 and R2 are independently hydrogen, halogen, alkyl having 1 to 10 carbons or alkyl having 1 to 10 carbons in which at least one of
hydrogen is replaced by fluorine; and

R3 is a group selected from the group of groups represented by formula (R-1);


wherein, X1 is independently halogen, alkyl having 1 to 6 carbons or alkyl having 1 to 6 carbons in which at least one of hydrogen is
replaced by fluorine; L is independently halogen, —CF3, —C?N or alkyl having 1 to 6 carbons; P1 and P2 are independently a group selected from the group of groups represented by formula (P-1) to formula (P-11); Y1 and Y2 are independently hydrogen, —CH3, —C2H5 or halogen; and Y3 is hydrogen, —CH3, —C2H5, halogen, —CF3 or —C?N;


wherein, Sp1 and Sp2 are independently a single bond or alkylene having 1 to 6 carbons, at least one of hydrogen of the alkylene may be replaced
by halogen or —C?N at least one of non-adjacent —CH2— may be replaced by —O—, —S—, —NH—, —CO—, —CO—O—, —O—CO—, —O—CO—O—, —CH?CH— or —C?C—; m1 and m3 are integers from 0 to 5, m2 is an integer from 0 to 4, and a sum of m1 and m3 is an integer from 1 to 10; n1 is an integer from 1 to 8; and p is an integer from 0 to 4.

US Pat. No. 9,850,428

COMPOUND HAVING POLY (DIFLUOROMETHYLENE) CHAIN, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound, represented by formula (1):
wherein, in formula (1),
R1 is alkyl having 3 to 15 carbons, alkyl having 2 to 15 carbons in which at least one of —CH2— is replaced by —O— or alkenyl having 4 to 15 carbons, and in the groups, at least one of hydrogen may be replaced by fluorine
or chlorine;

a is an integer from 4 to 12; and
R2 is a group represented by formula (1a), formula (1b) or formula (1c):

wherein, in formula (1a), formula (1b) and formula (1c),
S1 and S2 are independently a single bond or alkylene having 1 to 10 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —NH—, —CO—, —COO—, —OCO— or —OCOO—, and at least one of —(CH2)2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by fluorine or chlorine;

S3 is >CH— or >N—;

S4 is >C< or >Si<;

X1 is —OH, —NH2 or a group represented by —OR3, —N(R3)2 or —Si(R3)3, in which R3 is hydrogen or alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, at least one of —(CH2)2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by fluorine or chlorine;

in which, in formula (1), a sum of carbons in R1, S1, S2, S3, S4 and —(CF2)a— is at least 11; and

in which, a is 5, 7, 9, 10, 11 or 12 when R2 is a group represented by formula (1a), S1 is —(CH2)2— and X1 is —OH; and a is 4, 5, 6, 7, 9, 10, 11 or 12 when R2 is a group represented by formula (1a), S1 is —(CH2)3— and X1 is —OH.

US Pat. No. 9,701,095

BULKY NONWOVEN FABRIC

JNC CORPORATION, Tokyo (...

1. A bulky nonwoven fabric, comprising:
a fiber layer A comprising a spiral crimp fiber and at least one surface, and
a fiber layer B comprising a fiber, wherein the fiber layer B is laminated on the surface of the fiber layer A,
wherein the spiral crimp fiber of the fiber layer A and the fiber of the fiber layer B are partly entangled and integrated
at an interface in a thickness direction of both layers, and the fiber layer B exhibits a pleat structure in which the layer
is lifted up to the fiber layer B side between individual entangled parts; and

wherein the bulky nonwoven fabric has a specific volume of 30 cm3/g or more and a unit weight of from 30 to 100 g/m2.

US Pat. No. 9,683,238

VASCULAR ENDOTHELIAL GROWTH FACTOR-BINDING APTAMERS

National University Corpo...

1. A polynucleotide comprising the base sequence of any one of SEQ ID NOs:1 to 4, which polynucleotide binds to vascular endothelial
growth factor.
US Pat. No. 9,662,601

BLENDED FILAMENT NONWOVEN FABRIC

JNC CORPORATION, Tokyo (...

1. A blended filament nonwoven fabric, comprising a blend of two types of filaments, wherein
the two types of filaments are constituted of thermoplastic resins different from each other, wherein the thermoplastic resins
have different shear viscosities, and a difference in the shear viscosities, which is obtained by dividing a higher shear
viscosity value by a lower shear viscosity value, is 1.5 times or more,

an average fiber diameter obtained by dividing the total value of fiber diameters of the filaments present in the nonwoven
fabric by the number of the constituent filaments is 0.1 to 10 ?m, the ratio of the number of constituent filaments having
fiber diameters of 0.1 to 1.5 ?m exceed 30%, and that the ratio of the number of constituent filaments having fiber diameters
of 3 to 10 ?m be less than 30%, and

the nonwoven fabric has a specific volume of 20 cm3/g or more.

US Pat. No. 9,617,477

COMPOUND HAVING FOUR POLYMERIZABLE GROUPS, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein ring A1, ring A2, ring A3 and ring A4 are independently phenylene or cyclohexylene, and in these groups at least one hydrogen may be replaced by alkyl having 1
to 10 carbons, fluorine, —CF2H or —CF3;
Z1, Z2, Z3 and Z4 are independently a single bond, —COO—, —CH2O— or —CH?CHO—;

L1, L2 and L3 are independently a single bond, —CH?CH—, —CH?CH—COO—, —C(CH3)?CH—COO—, —CH?C(CH3)—COO—, —C(CH3)?C(CH3)—COO—, —C?C—, —COCH?CH—, —C(CH3)?C(CH3)—, —CH?CH—CH2O—, —CH?CH—OCH2— or —CO—, and at least one of L1, L2 and L3 is —CH?CH—, —CH?CH—COO—, —C(CH3)?CH—COO—, —CH?C(CH3)—COO—, —C(CH3)?C(CH3)—COO—, —C?C—, —COCH?CH—, —C(CH3)?C(CH3)—, —CH?CH—CH2O—, —CH?CH—OCH2— or —CO—;

s and t are independently 0 or 1, and the sum of s and t is 0, 1 or 2;
P1 , P2, P3 and P4 are the group (P-1):

wherein M is hydrogen, fluorine, -CH3 or -CF3.

US Pat. No. 9,593,094

LIQUID CRYSTAL MEDIUM, OPTICAL DEVICE, AND LIQUID CRYSTAL COMPOUND

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition, containing an achiral component (T) and a chiral agent (K), and exhibiting an optically isotropic
liquid crystal phase, wherein the achiral component (T) comprises, as a first component, at least one compound (1) represented
by formula (1),
wherein in formula (1),
R1 is hydrogen, alkyl having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkynyl having 2 to 12 carbons, or alkoxy having
1 to 11 carbons;

A1 is independently 1,3-dioxane-2,5-diyl, 1,4-phenylene, 3-fluoro-1,4-phenylene, 3,5-difluoro-1,4-phenylene or 3-fluoro-5-chloro-1,4-phenylene;

Z1 is independently a single bond, or alkylene having 1 to 4 carbons;

Z3 is —CF2O—;

L11 is hydrogen or fluorine;

Y1 is fluorine, —CF3 or —OCF3; and

n1 is 1;wherein the chiral agent (K) comprises, as a chiral component, at least one compound (K6-6) represented by formula (K6-6),
wherein in formula (K6-6), each RK is independently alkyl having 3 to 10 carbons.

US Pat. No. 9,562,190

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy, and contains at least one compound selected from
the group consisting of compounds represented by formula (1) as a first component:

wherein in formula (1), R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkenyloxy
having 2 to 12 carbons, or alkyl having 1 to 12 carbons in which at least one hydrogen is replaced by fluorine or chlorine;
ring A and ring B are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, tetrahydropyran-2,5-diyl, 1,4-phenylene, or 1,4-phenylene
in which at least one hydrogen is replaced by fluorine or chlorine; Z1and Z2 are independently a single bond, ethylene or carbonyloxy; X1 and X2 are independently hydrogen or fluorine; a is 0, 1, 2 or 3; b is 0 or 1; and a sum of a and b is 3 or less.

US Pat. No. 9,540,567

POLYMERIZABLE LIQUID CRYSTAL COMPOSITION AND OPTICALLY ANISOTROPIC BODY

JNC CORPORATION, Tokyo (...

1. A polymerizable liquid crystal composition, containing at least one kind of polymerizable liquid crystal compound having
one or more polymerizable functional groups in one molecule, and a solvent, wherein the solvent comprises a diacetate solvent
and a ketone solvent.
US Pat. No. 9,469,845

MUTATED GENES FOR THE CATALYTIC PROTEIN OF OPLOPHORUS LUCIFERASE AND USE THEREOF

JNC CORPORATION, Tokyo (...

1. A luciferase mutant selected from (a) to (d) below:
(a) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2;

(b) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 is an amino acid sequence in which 1 to 17 amino acids are deleted, substituted, inserted
and/or added in the amino acid sequence at the positions of 5 to 169 of SEQ ID NO: 2, and having a luciferase activity;

(c) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 has at least 90% identity to the amino acid sequence at the positions of 5 to 169 of SEQ
ID NO: 2, and having a luciferase activity; and,

(d) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 is encoded by a polynucleotide which hybridizes under stringent conditions to a polynucleotide
consisting of a nucleotide sequence complementary to a nucleotide sequence encoding the amino acid sequence at the positions
of 5 to 169 of SEQ ID NO: 2, wherein the high stringency conditions are 5 × SSC, 5 × Denhardt's solution, 0.5% (w/v) SDS,
50% (v/v) formamide, and 50° C., and having a luciferase activity.

US Pat. No. 9,453,163

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition having a nematic phase and containing at least one compound represented by formula (1-1-1)
as a first component and at least one compound represented by formula (2) as a second component:


wherein R5 is straight-chain alkyl having 1 to 12 carbons or straight-chain alkenyl having 2 to 12 carbons; R2 and R3 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkenyl
having 2 to 12 carbons in which at least one of hydrogen is replaced by fluorine; ring A and ring B are independently 1,4-cyclohexylene,
1,4-phenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene or 2,5-difluoro-1,4-phenylene; Z2 is independently a single bond, ethylene or carbonyloxy; and m is 1, 2 or 3.

US Pat. No. 9,441,161

LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein, in formula (1),
R1 is alkyl having 1 to 15 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O— or —S—, at least one of —(CH2)2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by halogen;

ring A1, ring A2, ring A3 and ring A4 are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl,
pyrimidine-2,5-diyl, pyridine-2,5-diyl, naphthalene-2,6-diyl, decahydronaphthalene-2,6-diyl or 1,2,3,4-tetrahydronaphthalene-2,6-diyl,
and at least one of hydrogen directly bonded to the rings thereof may be replaced by halogen;

W1 is a group represented by formula (1a) or formula (1b);

wherein, in formula (1a),
Y1 and Y2 are independently fluorine or chlorine;
in formula (1b),
Y3, Y4 and Y5 are independently hydrogen, fluorine or chlorine, and at least two of Y3, Y4 and Y5 are fluorine or chlorine; and
in formula (1),
W2 is a group represented by formula (1c) or formula (1d);

wherein, in formula (1c) and (1d),
L1, L2, L3, L4 and L5 are independently hydrogen, fluorine or chlorine; and
in formula (1),
X1 is fluorine, —C?N, —N?C?S, or alkyl having 1 to 10 carbons in which at least one of hydrogen is replaced by fluorine, alkenyl
having 2 to 10 carbons in which at least one of hydrogen is replaced by fluorine, alkoxy having 1 to 9 carbons in which at
least one of hydrogen is replaced by fluorine, or alkenyloxy having 2 to 9 carbons in which at least one of hydrogen is replaced
by fluorine;

a, b, c and d are independently 0 or 1, and a sum of a, b, c and d is 0, 1, 2 or 3;
Z1, Z2, Z3, Z4 and Z5 are independently a single bond, —(CH2)2—, —CH2O—, —OCH2—, —COO—, —OCO—, —(CH2)4—, —(CH2)2CF2O—, —OCH2CF2O—, —(CH2)3O—, —O(CH2)3— or —(CH2)2COO—;

at least one of Z1 when a is 1, Z2 when b is 1, Z3 when c is 1, Z4 when d is 1 and Z5 is —(CH2)2—, —CH2O—, —OCH2—, —COO—, —OCO—, —(CH2)4—, —(CH2)2CF2O—, —OCH2CF2O—, —(CH2)3O—, —O(CH2)3— or —(CH2)2COO—;

when Z5 is —COO—, ring W1 is a group represented by formula (1a) and ring W2 is a group represented by formula (1c), X1 is fluorine, or alkyl having 1 to 10 carbons in which at least one of hydrogen is replaced by fluorine, alkenyl having 2 to
10 carbons in which at least one of hydrogen is replaced by fluorine, alkoxy having 1 to 9 carbons in which at least one of
hydrogen is replaced by fluorine, or alkenyloxy having 2 to 9 carbons in which at least one of hydrogen is replaced by fluorine;

when Z5 is —COO—, ring W1 is a group represented by formula (1a), ring W2 is a group represented by formula (1c), a sum of a and b is 1, a sum of c and d is 0, ring A1 when a is 1 or ring A2 when b is 1 is 1,4-phenylene, Z1 when a is 1 or Z2 when b is 1 is a single bond, both Y1 and Y2 are fluorine and X1 is fluorine, both L1 and L2 are hydrogen or fluorine; and

when Z5 is —COO—, ring W1 is a group represented by formula (1a), ring W2 is a group represented by formula (1c), a sum of a, b, c and d is 0, both Y1 and Y2 are fluorine and X1 is —CF3, at least one of L1 and L2 is fluorine.

US Pat. No. 9,102,869

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy and a ratio of rotational viscosity (?1) to an elastic
constant (K33) in a range of 4.2 GPa·s/N or less, and contains a compound represented by formula (1-1) as a first component,
and at least one compound represented by formula (2) as a second component, wherein a ratio of the first component is in a
range of 15 wt % to 90 wt % based on a total weight of the liquid crystal composition:


wherein R1 is propyl; R3 and R4 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkenyloxy
having 2 to 12 carbons, alkyl having 1 to 12 carbons in which at least one hydrogen is replaced by fluorine, or alkenyl having
2 to 12 carbons in which at least one hydrogen is replaced by fluorine; ring A and ring C are independently 1,4-cyclohexylene,
1,4-phenylene, 1,4-phenylene in which at least one hydrogen is replaced by fluorine or chlorine, or tetrahydropyran-2,5-diyl;
ring B is 2,3-difluoro-1,4-phenylene, 2-chloro-3-fluoro-1,4-phenylene, 2,3-difluoro-5-methyl-1,4-phenylene, 3,4,5-trifluoronaphthalene-2,6-diyl
or 7,8-difluorochroman-2,6-diyl; Z1 and Z2 are independently a single bond, ethylene, methyleneoxy or carbonyloxy; m is 1, 2 or 3; and

n is 0 or 1, and a sum of m and n is 3 or less,
and wherein at least one compound in the second component is represented by formula (2-4-1):

wherein R8 is straight-chain alkyl having 1 to 12 carbons or straight-chain alkenyl having 2 to 12 carbons, and R10 is straight-chain alkyl having 1 to 12 carbons or straight-chain alkoxy having 1 to 12 carbons.

US Pat. No. 9,080,100

POLYMERIZABLE LIQUID CRYSTAL COMPOSITION

JNC CORPORATION, Tokyo (...

1. A polymerizable liquid crystal composition comprising:
component (A) which is at least one compound selected from the group of compounds represented by each of formula (1-1), formula
(1-2) and formula (1-3),

component (B) which is at least one compound selected from the group of compounds represented by each of formula (2-1), formula
(2-2) and formula (2-3),

component (C) which is at least one compound selected from the group of compounds represented by each of formula (3-1) to
formula (3-6),

component (E) which is a non-liquid crystalline polymerizable compound having a functional group including a hydroxyl group,
and having an acryloyl group or a methacryloyl group in one molecule, and

optionally comprising component (D) which is at least one compound selected from the group of compounds represented by each
of formula (4-1) and formula (4-2):

wherein, Z11 is independently hydrogen, fluorine, methyl or trifluoromethyl; W1 is independently hydrogen or fluorine; W2 and W3 are independently hydrogen or methyl; Z12 is independently hydrogen, fluorine, methyl or trifluoromethyl; W4 is hydrogen, methyl, straight-chain alkyl having 1 to 7 carbons, branched alkyl having 1 to 7 carbons, alkoxycarbonyl (—COORa; wherein Ra is straight-chain alkyl having 1 to 7 carbons) or alkylcarbonyl (—CORb; wherein Rb is straight-chain alkyl having 1 to 15 carbons); X1 is independently —O— or a group represented by formula (a); and m1, m2, n1 and n2 are independently an integer from 2 to 15;
wherein, Z21 is hydrogen or methyl; R1 is cyano, trifluoromethoxy, alkyl having 1 to 10 carbons or alkoxy having 1 to 10 carbons; W5 is hydrogen or fluorine; X2 is a single bond, —COO— or —OCO—; m3 is an integer from 2 to 15; Z22 is hydrogen or methyl; m4 is an integer from 2 to 15; W6 is hydrogen, fluorine or methoxy; X3 is a single bond, —COO—, —OCO—, —CH2CH2—COO— or —CH?CH—COO—, q1 is 1 or 2, and R2 is alkyl having 1 to 10 carbons; and X4 is —COO—, —OCO—, —CH2CH2—COO— or —CH?CH—COO—;
wherein,
in formula (3-1), L1a and L1b are independently alkyl having 1 to 4 carbons; R1a and R1b are independently alkylene having 2 to 4 carbons; Z31 is independently hydrogen or methyl; k1 and k2 are independently an integer from 0 to 4; and m31 and n31 are independently
an integer from 0 to 6;

in formula (3-2), Z32 is independently hydrogen or methyl; m32 and n32 are independently an integer from 1 to 3; L2a and L2b are independently alkyl having 1 to 6 carbons, phenyl or fluorine; and j1 and j2 are independently an integer from 0 to 4;

in formula (3-3), Z33 is independently hydrogen or methyl; R3a and R3b are independently hydrogen, methyl or ethyl; and m33 and n33 are independently an integer from 0 to 3;

in formula (3-4), Z34 is hydrogen or methyl; R4a and R4b are independently hydrogen or alkyl having 1 to 6 carbons; and m34 and n34 are independently an integer from 0 to 10;

in formula (3-5), Z35 is independently hydrogen or methyl; and

in formula (3-6), Z36 is independently hydrogen or methyl; R5a and R5b are independently hydrogen or alkyl having 1 to 6 carbons; L2a and L2b are independently alkyl having 1 to 6 carbons, phenyl or fluorine; j1 and j2 are independently an integer from 0 to 4; m35
and n35 are independently an integer from 1 to 3; and m36 and n36 are independently an integer from 1 to 3;

wherein, Z41 and Z42 are independently hydrogen or methyl; Y1 and Y2 are independently a single bond, —(CH2)2— or —CH?CH—; W7 and W8 are independently hydrogen or fluorine; and m5, m6, n5 and n6 are independently an integer from 2 to 15; and
wherein component (E) is butanediol monoacrylate, a reaction product between butyl glycidyl ether and (meth)acrylic acid,
3-chloro-2-hydroxypropyl methacrylate, glycerol methacrylate, glycerol acrylate, glycerol dimethacrylate, glycerol triacrylate,
2-hydroxyethyl acrylate, 2-hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxypropyl methacrylate, caprolactone-modified
2-hydroxyethyl acrylate, caprolactone-modified 2-hydroxyethyl methacrylate, phenoxyhydroxypropyl acrylate, 2-hydroxy-3-acryloyloxypropyl
methacrylate, bispropenoic acid [1,6-hexanediylbis[oxy(2-hydroxy-3,1-propanediyl)]]ester, triglycerol diacrylate, pentaerythritol
tri(meth)acrylate, dipentaerythritolmonohydroxy penta(meth)acrylate, polyethylene glycol mono(meth)acrylate having a polymerization
degree of 2 to 20, polypropylene glycol mono(meth)acrylate having a polymerization degree of 2 to 20, poly(ethylene glycol-propylene
glycol)mono(meth)acrylate, polyethylene glycol-polypropylene glycol mono(meth)acrylate, poly(ethylene glycol-tetramethylene
glycol)mono(meth)acrylate, poly(propylene glycol-tetramethylene glycol)mono(meth)acrylate, propylene glycol polybutylene glycol
mono(meth)acrylate, 2-acryloyloxyethyl succinate, 2-acryloyloxyethyl hexahydrophthalate, 2-acryloyloxyethyl phthalate, 2-acryloyloxyethyl-2-hydroxyethyl
phthalate, 2-acryloyloxyethyl acid phosphate, 2-methacryloyloxyethyl acid phosphate, 2-methacryloyloxyethyl succinate, 2-methacryloyloxyethyl
hexahydrophthalate, 2-acryloyloxyethyl-2-hydroxyethyl phthalate, 4-(2-acryloyloxyethy-1-yloxy)benzoic acid, 4-(3-acryloyloxy-n-prop-1-yloxy)benzoic
acid, 4-(2-methacryloyloxyethy-1-yloxy)benzoic acid, 4-(4-acryloyloxy-n-buty-1-yloxy)benzoic acid, 4-(6-acryloyloxy-n-hexy-1-yloxy)benzoic
acid, 4-(6-acryloyloxy-n-hexy-1-yloxy)-2-methylbenzoic acid, 4-(6-methacryloyloxy-n-hexy-1-yloxy)benzoic acid, 4-(10-acryloyloxy-n-deci-1-yloxy)benzoic
acid, 2-acryloyloxyethyl acid phosphate and 2-methacryloyloxyethyl acid phosphate.

US Pat. No. 9,853,225

CHALCOGEN-CONTAINING ORGANIC COMPOUND AND A USE THEREOF

JNC CORPORATION, Tokyo (...

1. A compound represented by Formula (1-1) or Formula (1-2):
wherein, in Formula (1-1) and Formula (1-2), each X is independently sulfur, or selenium; m is 0 or 1; each n existing at
two positions is 0; and each R3 existing at two positions is independently fluorine, alkyl having 1 to 20 carbons, aryl, pyridyl, furyl, thienyl or thiazolyl,
wherein at least one hydrogen in the alkyl may be replaced with fluorine, and at least one hydrogen on a ring of the aryl,
pyridyl, furyl, thienyl and thiazolyl may be replaced with at least one selected from the group consisting of fluorine and
alkyl having 1 to 10 carbons.

US Pat. No. 9,834,725

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy, and contains at least one compound selected from
the group of compounds represented by formula (1) as a first component:

wherein, in formula (1), R1 is alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkyl having 1 to 12 carbons
in which at least one piece of hydrogen is replaced by fluorine or chlorine, or alkenyl having 2 to 12 carbons in which at
least one piece of hydrogen is replaced by fluorine or chlorine; ring A and ring B are independently 1,4-cyclohexylene, 1,4-cyclohexenylene,
1,4-phenylene or 1,4-phenylene in which at least one piece of hydrogen is replaced by fluorine or chlorine, tetrahydropyran-2,5-diyl,
1,3-dioxane-2,5-diyl, pyrimidine-2,5-diyl, or pyridine-2,5-diyl; Z1 and Z2 are independently a single bond, —CH2CH2—, —C?C—, —CH?CH—, —CF?CF—, —CF2O—, —OCF2—, —CH2O—, —OCH2—, —COO— or —OCO—; L1, L2 and L3 are independently hydrogen, fluorine or chlorine; X1 and X2 are independently hydrogen or fluorine; and a is 0, 1, 2 or 3.

US Pat. No. 9,835,615

METHOD OF SCREENING A DRUG SUCH AS INSULIN SECRETAGOGUE

JNC CORPORATION, Tokyo (...

1. A polynucleotide encoding a fusion protein of preproinsulin and a luciferase, wherein the fusion protein is a polypeptide
selected from the group consisting of (a) through (c) below:
(a) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 12;
(b) a polypeptide comprising a polypeptide consisting of an amino acid sequence comprising deletion, substitution, insertion
and/or addition of 1-10 amino acid residues in the amino acid sequence of SEQ ID NO: 12, and having substantially the same
activity as the polypeptide consisting of the amino acid sequence of SEQ ID NO: 12; and

(c) a polypeptide comprising a polypeptide consisting of an amino acid sequence having at least 90% identity to the amino
acid sequence of SEQ ID NO: 12, and having substantially the same activity as the polypeptide consisting of the amino acid
sequence of SEQ ID NO: 12.

US Pat. No. 9,783,481

CARBONYL DERIVATIVE, LIQUID CRYSTAL COMPOSITION CONTAINING COMPOUND THEREOF AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by any one of formulas (1-21) to (1-27):
wherein, in formulas (1-21) to (1-27),
Ra and Rb are independently alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons, alkoxy having 1 to 9 carbons, fluorinated
alkyl having 1 to 10 carbons or fluorinated alkoxy having 1 to 9 carbons;

A1 and A2 are independently 1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 2,3-difluoro-1,4-phenylene, cyclohexene-1,4-diyl
or tetrahydropyran-2,5-diyl;

Z1 is independently a single bond, —(CH2)2—, —(CH2)4—, —CH2O—, —OCH2—, —CF2O—, —OCF2—, —CH?CH— or —C?C—; and

Y1 is —CF2H.

US Pat. No. 9,732,275

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy, and contains at least one compound selected from
the group of compounds represented by formula (1) as a first component, and a compound represented by formula (2) as a second
component:

wherein, in formula (1), R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkenyloxy
having 2 to 12 carbons, or alkyl having 1 to 12 carbons in which at least one of hydrogen is replaced by fluorine or chlorine;
Z1 and Z2 are independently a single bond, ethylene, carbonyloxy or methyleneoxy; and X1, X2, X3 and X4 are independently hydrogen, fluorine or chlorine, wherein, at least one of X1, X2, X3 and X4 is fluorine or chlorine.

US Pat. No. 9,751,280

RUGGED ELASTIC NONWOVEN FABRIC AND METHOD FOR MANUFACTURING THE SAME

JNC CORPORATION, Tokyo (...

1. A nonwoven fabric in which a first fibrous layer and a second fibrous layer are laminated using the first fibrous layer
containing heat-shrinkable fibers (1A) being latent crimp conjugate fibers and the second fibrous layer containing heat-fusible heat-shrinkable fibers (2A) having a smaller shrinkage as compared with the heat-shrinkable fibers (1A), a difference in shrinkage between the heat-shrinkable fibers (1A) and the heat-shrinkable fibers (2A) is 10% or more, and a portion of fibers constituting the first fibrous layer are bonded to a portion of fibers constituting
the second fibrous layer by a plurality of bonded parts between the first fibrous layer and the second fibrous layer, which
are arranged at intervals, such that the two fibrous layers are united, wherein an area of one of the bonded parts is in the
range of 0.5 to 20 mm2, a distance between the bonded parts is in the range of 2 to 20 millimeters, a maximum shrinkage development temperature
of the first fibrous layer is 145° C. or higher, and a melting point or a softening point of a heat-fusible component of the
heat-shrinkable fibers (2A) is in the range of 70° C. or higher to 125° C. or lower, a melt mass flow rate of the heat-fusible component of the heat-shrinkable
fibers (2A) is in the range of approximately 0.1 g/10 min to approximately 80 g/10 min, the second fibrous layer between the bonded
parts is projected in a convex by shrinking of the first fibrous layer, fibers constituting the first fibrous layer are not
substantially bonded with each other by thermal melting, the first fibrous layer comprises a combination of polypropylene
(PP) and ethylene-propylene rubber (EPM), the second fibrous layer comprises a combination of polypropylene (PP) and olefin-based
elastomer, and the bonded parts are formed by heat-press bonding.

US Pat. No. 9,751,286

WEATHER-RESISTANT MULTILAYER FILM

JNC CORPORATION, Tokyo (...

1. A weather-resistant multilayer film, comprising:
a transparent film-like substrate;
a UV-absorbing resin layer laminated on the substrate and containing an organic UV absorber n a proportion of 10 to 90 wt
%, wherein the organic UV absorber is at least one selected from the group consisting of benzotriazoles, hydroxyphenyl triazines,
benzophenones, salicylates, cyanoacrylates, triazines and dibenzoyl risorcinols;

a first cured resin layer laminated on the UV-absorbing resin layer, wherein the first cured resin layer does not contain
an organic UV absorber; and

a second cured resin layer laminated on a side of the substrate opposite the UV-absorbing resin layer,
wherein the first cured resin layer has a thickness of 1.0 to 10 ?m,
the UV-absorbing resin layer has a thickness of 0.5 to 5 ?m,
the UV-absorbing resin layer has an absorption wavelength of 200 to 500 nm,
the first cured resin layer contains a UV-curable resin,
the transparent film-like substrate comprises polyethylene terephthalate (PET), and
the second cured resin layer has a surface free energy of 30 to 45 mN/m.

US Pat. No. 9,714,383

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a positive dielectric anisotropy, and contains at least one compound selected from
the group of compounds represented by formula (1) as a first component:

wherein, in formula (1), R1, R2 and R3 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkenyl
having 2 to 12 carbons in which at least one of hydrogen is replaced by fluorine, and one of R2 and R3 may be hydrogen; ring A is 1,4-phenylene, 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,3-dioxane-2,5-diyl, tetrahydropyran-2,5-diyl,
or 1,4-phenylene in which at least one of hydrogen is replaced by fluorine, chlorine or methyl; X1, X2 and X3 are independently fluorine, chlorine, or alkyl having 1 to 12 carbons in which at least one of hydrogen may be replaced by
fluorine; Z1, Z2, Z3 and Z4 are independently a single bond, —CH2CH2—, —CH2O—, —OCH2—, —COO— or —OCO—; a, b and c are independently 0, 1, 2, 3 or 4; and d is 0, 1 or 2.

US Pat. No. 9,714,942

DETECTION METHOD AND DETERMINATION METHOD FOR DETECTION TARGET

JNC CORPORATION, Tokyo (...

1. A method for detecting in a sample a target substance comprising an electrically charged moiety or a hydrophilic moiety,
comprising:
i) mixing the sample with a first bound substance, said first bound substance comprising a stimuli-responsive polymer, a particulate
magnetic material, and a first affinity substance, wherein said particulate magnetic material binds to said stimuli-responsive
polymer and binds to said first affinity substance, said first affinity substance having affinity to the target substance,
and wherein aggregation of said stimuli-responsive polymer is inhibited when the electrically charged moiety or the hydrophilic
moiety of said target substance is brought into close proximity to said stimuli-responsive polymer by binding said first affinity
substance to said target substance, and wherein the stimuli-responsive polymer aggregates if the target is not bound;

ii) placing said sample and first bound substance under predetermined conditions to aggregate the stimuli-responsive polymer
followed by

iii) applying a magnetic force thereto; and
iv) measuring an increase in the intensity of generated magnetic field as compared to the intensity of the magnetic field
before applying the magnetic force, and detecting the target substance based on an amount of the increase in the intensity
of the magnetic field, wherein in a case where the increase is detected, the target substance is determined not to be present
in the sample, and in a case where an increase is not detected, the target substance is determined to be present in the sample.

US Pat. No. 9,708,534

POLYMERIZABLE COMPOUND HAVING TRIPLE BOND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A polymerizable composition, containing at least one compound selected from the group of compounds represented by formula
(1) and at least one compound selected from the group of compounds represented by formulas (2) to (4):
wherein, in formula (1),
P1, P2, P3, P4, P5 and P6 are independently a polymerizable group;

S1, S2, S3, S4, S5 and S6 are independently a single bond or alkylene having 1 to 12 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —COO— or —OCO—, at least one of —CH2CH2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by halogen;

a1, a3 and a4 are independently 0, 1, 2, 3 or 4, a2 is 1, 2, 3 or 4, a sum of a1, a2, a3 and a4 is 3 to 10, in which either
or both of -S1-P1 and -S6-P6 may be hydrogen;

ring A1, ring A2, ring A3 and ring A4 are independently a divalent group derived from benzene, anthracene, pyrimidine or pyridine, and in the divalent group, at
least one of hydrogen may be replaced by halogen, alkyl having 1 to 12 carbons, or alkyl having 1 to 12 carbons in which at
least one of hydrogen is replaced by halogen, and ring A2 and ring A3 may be independently a divalent group derived from cyclohexane, cyclohexene, tetrahydropyran or dioxane;

Z1, Z2 and Z3 are independently a single bond or alkylene having 1 to 12 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —CO—, —COO— or —OCO—, at least one of —CH2—CH2— may be replaced by —CH?CH—, —C(CH3)?CH—, —CH?C(CH3), —C(CH3)?C(CH3)— or —C?C—, and in the groups, at least one of hydrogen may be replaced by halogen, and at least one of Z1, Z2 and Z3 is —C?C—, wherein when the number of —C?C— is two or more, or when at least one of Z1, Z2 and Z3 is a single bond, —CH?CH—, —COO—, or —OCO—, S1 and S6 are single bonds; and

b1 is 0 or 1;
wherein, in formulas (2) to (4),
R11 and R12 are independently alkyl having 1 to 10 carbons or alkenyl having 2 to 10 carbons, and in the alkyl or the alkenyl, at least
one of —CH2— may be replaced by —O—, and at least one of hydrogen may be replaced by fluorine;

ring B1, ring B2, ring B3 and ring B4 are independently 1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 2,5-difluoro-1,4-phenylene or pyrimidine-2,5-diyl;
and

Z11, Z12 and Z13 are independently a single bond, —CH2CH2—, —CH?CH—, —C?C— or —COO—.

US Pat. No. 9,657,229

LIQUID CRYSTAL COMPOUND HAVING DIFLUOROMETHYLENEOXY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound having a positive dielectric anisotropy represented by formula (1):
wherein, in formula (1),
R1 is alkyl having 1 to 15 carbons, in the alkyl, at least one of —CH2— may be replaced by —O— or —S—, at least one of —(CH2)2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by halogen;

ring A1, ring A2, ring A3 and ring A4 are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, 1,4-phenylene in which at least one of hydrogen is
replaced by halogen, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl, pyrimidine-2,5-diyl
or pyridine-2,5-diyl;

Z1, Z2, Z3 and Z4 are independently a single bond, —(CH2)2—, —CH?CH—, —C?C—, —COO—, —OCO—, —CF2O—, —OCF2—, —CH2O—, —OCH2— or —CF?CF—;

X1 is fluorine, chlorine, —C?N, —CF3, —CHF2, —OCF3, —OCHF2, —CH?CHCF3, —CF?CHCF3, or —CF?CFCF3;

L1 is fluorine and L2 is hydrogen or fluorine;

Y1 and Y2 are independently fluorine or chlorine;

a, b, c and d are independently 0 or 1, a sum of a, b, c and d is 0, 1, 2 or 3.

US Pat. No. 9,657,230

ALKENYL DIOXANE COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in formula (1), R1 is alkenyl having 2 to 10 carbons, and in the alkenyl, at least one hydrogen may be replaced by fluorine; ring A1 and ring A2 are each independently 1,4-cyclohexylene, 1,4-phenylene, or 1,4-phenylene in which at least one hydrogen is replaced by fluorine;
Z1, Z2 and Z3 are each independently a single bond, —COO—, —OCH2—, —CF2O—, —CH2CH2—, —CF2CF2—, —CF?CF—, —C?C—, —(CH2)4— or —CH2CH?CHCH2—; X1 is hydrogen, fluorine, —CF3 or —OCF3; L1, L2, L3 and L4 are each independently hydrogen or fluorine; and a and b are each independently 0 or 1, a sum of a and b is 1, and when a
is 1, at least one of ring A1 and ring A2 is 1,4-cyclohexylene.

US Pat. No. 9,688,915

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a positive dielectric anisotropy and a nematic phase, and contains at least one compound
selected from the group consisting of compounds having two or more monovalent groups represented by formula (1) as an additive,
and at least one compound selected from the group consisting of compounds represented by formula (2) as a first component:

wherein in formulae (1) and (2), R1 is hydrogen or alkyl having 1 to 15 carbons; R2 is alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons; ring A is 1,4-cyclohexylene,
1,4-phenylene, 2-fluoro-1,4-phenylene, 2,6-difluoro-1,4-phenylene, 1,3-dioxane-2,5-diyl or tetrahydropyran-2,5-diyl; Z1 is a single bond, ethylene, carbonyloxy or difluoromethyleneoxy; X1 and X2 are independently hydrogen or fluorine; Y1 is fluorine, chlorine, or alkyl having 1 to 12 carbons in which at least one hydrogen is replaced by halogen, or alkoxy having
1 to 12 carbons in which at least one hydrogen is replaced by halogen; and a is 1, 2, 3 or 4,

wherein a proportion of the additive is in a range of 0.03 wt % to 0.3 wt % based on a weight of the liquid crystal composition,
and

wherein at least one compound in the first component is a compound of formula (2) with X1, X2 and Y1 being fluorine.

US Pat. No. 9,663,716

TETRAHYDROPYRAN COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1-1-1), (1-1-3), (1-1-4), or (1-1-6):
wherein
R1 and R2 are independently hydrogen, alkyl having 1 to 10 carbons or alkoxy having 1 to 9 carbons;

the ring A1, the ring A2, the ring A3, the ring A4, the ring A5 and the ring A6 are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, 1,3-dioxane-2,5-diyl, pyrimidine-2,5-diyl, pyrimidine-3,6-diyl,
pyridine-2,5-diyl or pyridine-3,6-diyl.

US Pat. No. 9,624,435

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition, containing at least one compound selected from the group consisting of compounds represented
by formula (1) as a first component and at least one compound selected from the group consisting of compounds represented
by formula (2) as a second component:

wherein in formula (1), R1 is straight alkyl having 2 to 25 carbons or branched alkyl having 3 to 25 carbons, and in the alkyl, at least one —CH2— may be replaced by —O—, —COO—, —OCO— or —OCOO—, at least one —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and in the groups, at least one hydrogen may be replaced by halogen; L is a group selected
from the group consisting of divalent groups represented by formula (L-1) to formula (L-3);


wherein in formula (L-1) to formula (L-3), R2, R3, R4 and R5 are independently hydrogen, fluorine, methyl, ethyl or trifluoromethyl;

in formula (1), Z1 is a single bond or alkylene having 1 to 10 carbons, and in the alkylene, at least one —CH2— may be replaced by —O—, —COO—, —OCO— or —OCOO—, at least one —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and at least one hydrogen may be replaced by halogen; X is —H, —OH, —OR6, —COOH, —COOR6, —NH2, —NHR6, —NR62, —SH, —SR6, —S—SR6 or a group derived from a heterocycle containing at least one —NH— group and having 3 to 20 carbons, and in the heterocycle,
at least one hydrogen may be replaced by halogen;

R6 is alkyl having 1 to 6 carbons; and a is 1, 2 or 3;

in formula (2), ring A is 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, naphthalene-1,2-diyl, naphthalene-1,3-diyl,
naphthalene-1,4-diyl, naphthalene-1,5-diyl, naphthalene-1,6-diyl, naphthalene-1,7-diyl, naphthalene-1,8-diyl, naphthalene-2,3-diyl,
naphthalene-2,6-diyl, naphthalene-2,7-diyl, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, pyrimidine-2,5-diyl or pyridine-2,5-diyl,
and in the rings, at least one hydrogen may be replaced by halogen, alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons,
or alkyl having 1 to 12 carbons in which at least one hydrogen is replaced by halogen; ring B is cyclohexyl, cyclohexenyl,
phenyl, 1-naphthyl, 2-naphthyl, tetrahydropyran-2-yl, 1,3-dioxane-2-yl, pyrimidine-2-yl or pyridine-2-yl, and in the rings,
at least one hydrogen may be replaced by halogen, alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, or alkyl having
1 to 12 carbons in which at least one hydrogen is replaced by halogen; P1, P2 and P3 are independently a polymerizable group; Z2, Z4 and Z5 are independently a single bond or alkylene having 1 to 10 carbons, and in the alkylene, at least one —CH2— may be replaced by —O—, —COO—, —COO— or —OCOO—, at least one —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and in the groups, at least one hydrogen may be replaced by fluorine or chlorine; Z3 is a single bond or alkylene having 1 to 10 carbons, and in the alkylene, at least one —CH2— may be replaced by —O—, —CO—, —COO— or —OCO—, at least one —CH2—CH2— may be replaced by —CH?CH—, —C(CH3)?CH—, —CH?C(CH3)— or —C(CH3)?C(CH3)—, and in the groups, at least one hydrogen may be replaced by fluorine or chlorine; b is 0, 1, 2 or 3; and c and d are independently
0, 1, 2 or 3.

US Pat. No. 9,611,429

LIQUID CRYSTAL MEDIUM, OPTICAL DEVICE AND LIQUID CRYSTAL COMPOUND

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that contains achiral component T containing at least one compound 1 represented by formula
(1), and a chiral agent, and develops an optically isotropic liquid crystal phase:

wherein, in formula (1), R1 is hydrogen or alkyl having 1 to 20 carbons, at least one of —CH2— in the alkyl may be replaced by —O—, —S—, —COO—, —OCO—, —CH?CH—, —CF?CF— or —C?C—, at least one of hydrogen in the alkyl
or in a group in which —CH2— in the alkyl is replaced by —O—, —S—, —COO—, —OCO—, —CH?CH—, —CF?CF— or —C?C— may be replaced by halogen or alkyl having
1 to 3 carbons; and

L1 and L2 are each independently fluorine or hydrogen, and

X1 is halogen, —CF3, —OCF3, —C?N or —N?C?S.

US Pat. No. 9,605,209

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy and contains at least one compound selected from
the group of compounds represented by formula (1) as a first component and at least one compound selected from the group of
compounds represented by formula (2) as a second component, wherein a proportion of the first component is in a range of 10
wt % to 40 wt % based on a weight of the liquid crystal composition:
wherein in formula (1) and formula (2), R1 is alkenyl having 2 to 12 carbons; R2 is alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkenyloxy having 2 to 12
carbons, or alkyl having 1 to 12 carbons in which at least one hydrogen is replaced by halogen; R3 and R4 are independently alkyl having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkyl having 1 to 12 carbons in which at least
one hydrogen is replaced by halogen, or alkenyl having 2 to 12 carbons in which at least one hydrogen is replaced by halogen;
ring A is 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, 1,4-phenylene in which at least one hydrogen is replaced
by fluorine or chlorine, or tetrahydropyran-2,5-diyl, with a proviso that at least one ring A is tetrahydropyran-2,5-diyl;
Z1 is a single bond, ethylene or carbonyloxy; and m is 2 or 3.

US Pat. No. 9,541,690

FILM USING POLYMERIZABLE LIQUID CRYSTAL COMPOSITION CONTAINING PEELING PREVENTIVE AGENT

JNC CORPORATION, Tokyo (...

1. A film comprising at least an alignment layer and a liquid crystal composition layer in order on a support substrate,
wherein the liquid crystal composition layer is obtained by immobilizing alignment of a polymerizable liquid crystal compound
contained in a polymerizable liquid crystal composition, an alignment state thereof includes homogeneous alignment, and the
polymerizable liquid crystal composition contains one kind or two or more kinds of antistripping additives having a radically
polymerizable group and a cationically polymerizable group in a molecule, the polymerizable liquid crystal compound consisting
essentially of one or more compounds selected from the formula

R1—X1?A1-Z1?sA1-X1—P1  (M1)

P1—X1?A1-Z1?sA1-X1—P1  (M2)

wherein P1 is independently a polymerizable group; R1 is independently hydrogen, fluorine, chlorine, —CN or alkyl having 1 to 20 carbons, and in the alkyl, arbitrary —CH2— may be replaced by —O—, —COO— or —OCO—, and arbitrary hydrogen may be replaced by halogen; A1 is independently 1,4-cyclohexylene, 1,4-phenylene, pyridine-2,5-diyl, pyrimidine-2,5-diyl, naphthalene-2,6-diyl or fluorene-2,7-diyl,
but arbitrary hydrogen may be replaced by halogen, alkyl having 1 to 5 carbons or alkyl halide having 1 to 5 carbons; X1 is independently a single bond or alkylene having 1 to 20 carbons, and arbitrary —CH2— in the alkylene may be replaced by —O—,—COO— or —OCO—; Z1 is independently a single bond, —COO—, —OCO—, —CH2CH2—, —CH?CH—, —C?C—, —CH2O—, —OCH2—, —CF2O—, —OCF2—, —CH2CH2COO—, —OCOCH2CH2—, —CH?CHCOO— or —OCOCH?CH—; and s is independently an integer from 1 to 5.

US Pat. No. 9,518,222

LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein, in formula (1),
R1 is alkyl having 1 to 15 carbons, in the alkyl, at least one of —CH2— may be replaced by —O— or —S—, at least one of —(CH2)2— may be replaced by —CH?CH—, and in the groups, at least one of hydrogen may be replaced by halogen;

ring A1, ring A2, ring A3 and ring A4 are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl,
pyrimidine-2,5-diyl, pyridine-2,5-diyl, chroman-2,6-diyl, 2,3-dihydro-1H-indene-2,5-diyl, naphthalene-2,6-diyl, decahydronaphthalene-2,6-diyl
or 1,2,3,4-tetrahydronaphthalene-2,6-diyl, and at least one of hydrogen directly bonded with the above rings may be replaced
by halogen;

W1 is a group represented by formula (1a) or formula (1b);

wherein, in formula (1a) and formula (1b),
Y1 and Y2 are independently fluorine or chlorine, Y3, Y4 and Y5 are independently hydrogen, fluorine or chlorine, and at least two of Y3, Y4 and Y5 is fluorine or chlorine; and
in formula (1),
W2 is a group represented by formula (1c) or formula (1d);

wherein, in formula (1c) and formula (1d),
L1, L2, L3, L4 and L5 are independently hydrogen, fluorine or chlorine; and
in formula (1),
when W1 is represented by formula (1a) and W2 is represented by formula (1c), at least one of ring A1, ring A2, ring A3 and ring A4 is naphthalene-2,6-diyl in which at least one of hydrogen may be replaced by halogen;

X1 is fluorine, —C?N, —N?C?S or alkyl having 1 to 10 carbons in which at least one of hydrogen is replaced by fluorine, alkenyl
having 2 to 10 carbons in which at least one of hydrogen is replaced by fluorine, alkoxy having 1 to 9 carbons in which at
least one of hydrogen was replaced by fluorine, or alkenyloxy having 2 to 9 carbons in which at least one of hydrogen is replaced
by fluorine;

a, b, c and d are independently 0 or 1, and a sum of a, b, c and d is 0, 1, 2 or 3;
Z1, Z2, Z3, Z4 and Z5 are independently a single bond or alkylene having 1-6 carbons, in the alkylene, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, one or two of —CH2CH2— may be replaced by —CH?CH— or —C?C—, and in the divalent groups, at least one of hydrogen may be replaced by fluorine or
chlorine; and

at least one of Z1 in the case where a is 1, Z2 in the case where b is 1, Z3 in the case where c is 1, Z4 in the case where d is 1, and Z5 is —CF2O—.

US Pat. No. 9,487,701

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition having a nematic phase and including at least one compound selected from the group of compounds
represented by formula (1) as a first component and at least one compound selected from the group of compounds represented
by formula (2) as a second component, wherein the group of compounds represented by formula (2) at least comprises one compound
selected from the group of compounds represented by formula (2-12) or formula (2-13), and the liquid crystal composition doesn't
contain a cyano compound:

wherein R1 is independently alkyl having 1 to 12 carbons; R2 is independently alkyl having 1 to 12 carbons, or alkoxy having 1 to 12 carbons; R3 is independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkenyl having
2 to 12 carbons in which arbitrary hydrogen is replaced by fluorine; ring A is independently 1,4-cyclohexylene, 1,4-phenylene,
2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene, 3,5-difluoro-1,4-phenylene, 1,3-dioxane-2,5-diyl, or tetrahydropyran-2,5-diyl,
at least one of rings A is 1,4-phenylene, 3-fluoro-1,4-phenylene, or 3,5-difluoro-1,4-phenylene; Z1 is independently a single bond, ethylene, carbonyloxy, or difluoromethyleneoxy; X1, X2, X3, X4, X5, X6, and X7 are independently hydrogen or fluorine; Y1 is independently fluorine, chlorine, or trifluoromethoxy; m is 1, 2, 3, or 4.

US Pat. No. 9,469,809

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy and contains at least one compound selected from
the group of compounds represented by formula (1) as a first component and at least one compound selected from the group of
compounds represented by formula (2-1) as a second component:

wherein R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons or alkenyl having 2 to 12 carbons, or alkenyl
having 2 to 12 carbons in which at least one of hydrogen is replaced by fluorine; R3 is independently ethyl or vinyl; R4 is propyl; ring A and ring B are independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, 1,4-phenylene in which
at least one of hydrogen is replaced by fluorine, or tetrahydropyran-2,5-diyl; X1 and X2 are fluorine; Z1 and Z2 are independently a single bond, ethylene, methyleneoxy, carbonyloxy or difluoromethyleneoxy; m is 0, 1 or 2; and n is 0 or
1.

US Pat. No. 9,441,162

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy and a nematic phase, and contains at least one compound
selected from the group consisting of compounds represented by formula (1):
wherein, in formula (1), R1 is hydrogen or alkyl having 1 to 15 carbons; R2, R3, R4 and R5 are independently hydrogen or alkyl having 1 to 4 carbons; ring A is phenyl or cyclohexyl; and a is 3 or 4.

US Pat. No. 9,375,867

TRANSFER FILM FOR IN-MOLD MOLDING AND METHOD FOR PRODUCING SAME

JNC CORPORATION, Tokyo (...

1. A transfer film for in-mold molding, comprising:
a transfer layer to be transferred onto an in-mold molded article and to be cured by irradiation of an active energy beam
after the transfer; and

a film-like substrate;
wherein the transfer layer has an IMD layer that is laminated on the substrate and an anchor layer laminated on the side of
the IMD layer opposite the substrate, the IMD layer will form the outermost layer of the molded article after in-mold molding,
and the anchor layer contains a cured thermosetting resin that enhances the adhesion between the IMD layer and a layer laminated
on the IMD layer; and

the IMD layer is composed of a mixed composition containing at least one active energy beam-curable resin and at least one
thermosetting resin, and at least one thermosetting resin contained in the IMD layer is of the same type as the thermosetting
resin contained in the anchor layer.

US Pat. No. 9,857,505

LAMINATE BODY AND MANUFACTURING METHOD THEREOF

JNC CORPORATION, Tokyo (...

1. A laminate body comprising:
a transparent substrate; and
a refractive layer for refracting incident light provided on an upper side of the substrate;
wherein the refractive layer is a single layer, the single layer is consisting of a fluorine compound and a resin, the fluorine
compound is at least one compound selected from a group consisting of fluorosilsesquioxane and fluorosilsesquioxane polymers,
and the refractive layer comprises 0.1 to 4% by weight of fluorine (F) based on the resin,

wherein a concentration of the fluorine compound dispersed in the resin of the refractive layer is higher on a side opposite
the substrate than on a side facing the substrate,

wherein the refractive layer being a graded-structure layer having a low refractive index and a high refractive index therein,
wherein the fluorine compound has a refractive index of 1.20 to 1.50,
wherein the resin has a refractive index of 1.50 to 2.20, and
wherein the laminate body has an antireflection function.

US Pat. No. 9,790,427

LIQUID CRYSTAL COMPOUND HAVING A 3,6-DIHYDRO-2H-PYRAN RING, NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in formula (1),
Ra and Rb are independently hydrogen or alkyl having 1 to 10 carbons, and in the alkyl, at least one —CH2— may be replaced by —O— or —S—, —CO— or —SiH2—, at least one —CH2CH2— may be replaced by —CH?CH— or —C?C—, and in the groups, at least one hydrogen may be replaced by fluorine or chlorine, and
Rb may be fluorine, chlorine, —C?N or —C?C—C?N;

ring A1, ring A2 and ring A3 are independently 1,4-cyclohexylene, decahydronaphthalene-2,6-diyl or 1,4-phenylene, and in the groups, at least one —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, at least one —CH2CH2— may be replaced by —CH?CH— or —CH?N—, and in the divalent groups, at least one hydrogen may be replaced by fluorine, chlorine,
—C?N, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F; and

ring N1 is 1,4-cyclohexylene, decahydronaphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl,
1,4-phenylene, naphthalene-2,6-diyl, 9,10-dihydrophenanthrene-2,7-diyl, 9H-xanthene-2,6-diyl or 9H-fluorene-2,7-diyl, and
in the groups, at least one —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, at least one —CH2CH2— may be replaced by —CH?CH— or —CH?N—, and in the divalent groups, at least one hydrogen may be replaced by fluorine, chlorine,
—C?N, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F;

G is a divalent group represented by formula (pr-1) or (pr-2);

wherein,
Z1 and Z2 are independently a single bond or alkylene having 1 to 6 carbons, and in the alkylene, at least one —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, one or two pieces of —CH2CH2— may be replaced by —C?C—, and in the divalent groups, at least one hydrogen may be replaced by fluorine or chlorine;

Z3 and Z4 are independently a single bond or alkylene having 1 to 6 carbons, and in the alkylene, at least one —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, one or two pieces of —CH2CH2— may be replaced by —CH?CH— or —C?C—, and in the divalent groups, at least one hydrogen may be replaced by fluorine or chlorine;

a, b and c are independently 0, 1 or 2, and a sum of a, b and c is an integer from 0 to 3;
when Ra is —C3H7, Rb is —OC2H5, a is 1, b and c are 0, ring A1 is tetrahydropyran-2,5-diyl, Z1 and Z3 are a single bond and ring N1 is 2,3-difluoro-1,4-phenylene, G is a divalent group represented by formula (pr-2);

when Ra is —C5H11, Rb is —OC2H5, a, b and c are 0, Z3 is a single bond and ring N1 is 2,3-difluoro-1,4-phenylene, G is a divalent group represented by formula (pr-2); and

when Ra is —CH?CH2 or —C2H5, Rb is —OC2H5, a, b and c are 0, Z3 is a single bond and ring N1 is 2,3-difluoro-1,4-phenylene, G is a divalent group represented by formula (pr-1).

US Pat. No. 9,790,428

PIPERIDINE DERIVATIVE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein, in formula (1),
R1, R2, R3 and R4 are independently hydrogen or alkyl having 1 to 4 carbons, and R5 is hydrogen, hydroxy, oxy radical, alkyl having 1 to 10 carbons or alkoxy having 1 to 10 carbons;

ring A1 is 1,4-cyclohexylene, 1,4-cyclohexenylene, 3,4-dihydro-2H-pyrane-2,5-diyl, 3,4-dihydro-2H-pyrane-3,6-diyl, 3,6-dihydro-2H-pyrane-2,5-diyl,
tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, 1,2-phenylene, 1,3-phenylene, 1,4-phenylene, pyridine-2,5-diyl, pyrimidine-2,5-diyl,
decahydronaphthalene-2,6-diyl, naphthalene-1,3-diyl, naphthalene-1,4-diyl, naphthalene-1,5-diyl, naphthalene-1,6-diyl, naphthalene-1,7-diyl,
naphthalene-1,8-diyl, naphthalene-2,3-diyl, naphthalene-2,6-diyl or naphthalene-2,7-diyl, and in the rings, at least one hydrogen
may be replaced by fluorine, chlorine, alkyl having 1 to 5 carbons, alkoxy having 1 to 5 carbons, or alkyl having 1 to 5 carbons
in which at least one hydrogen is replaced by fluorine or chlorine, and one hydrogen may be replaced by a monovalent group
represented by formula (P-1);

wherein, in formula (P-1),
R1, R2, R3 and R4 are independently hydrogen or alkyl having 1 to 4 carbons, and R5 is hydrogen, hydroxy, oxy radical, alkyl having 1 to 10 carbons or alkoxy having 1 to 10 carbons;

Z2 is a single bond or alkylene having 1 to 10 carbons, and in the alkylene, at least one —CH2— may be replaced by —O—, —S—, —CO—, —COO— or —OCO—, and at least one —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and in the groups, at least one hydrogen may be replaced by fluorine or chlorine; and

in formula (1),
Z1 and Z2 are independently a single bond or alkylene having 1 to 10 carbons, and in the alkylene, at least one —CH2— may be replaced by —O—, —S—, —CO—, —COO— or —OCO—, and at least one —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and in the groups, at least one hydrogen may be replaced by fluorine or chlorine; and

a is 0, 1, 2 or 3.

US Pat. No. 9,783,736

LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound, represented by formula (1):

wherein, in formula (1),
Ra and Rb are independently alkyl having 1 to 30 carbons, and in the groups, at least one —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, at least one —CH2CH2— may be replaced by —CH?CH— or —C?C—, and in the monovalent groups, at least one hydrogen may be replaced by fluorine or
chlorine; and

X and Y are independently fluoroalkyl having 1 to 5 carbons, fluoroalkoxy having 1 to 5 carbons or pentafluorosulfanil, and
one of X and Y may be fluorine.

US Pat. No. 9,748,542

COMPOSITE POROUS FILM HAVING EXCELLENT HEAT RESISTANCE

JNC CORPORATION, Tokyo (...

1. A composite porous film comprising a heat-resistantlayer formed of an inorganic filler and a binder, and a microporous membrane formed of a polyolefin resin, wherein the heat-resistant
layer is laminated on the microporous membrane, a primary particle size of the inorganic filler is 5 nanometers to 100 nanometers,
a weight average molecular weight (Mw) of the binder is 300,000 to 1,000,000, a molecular weight distribution (Mw/Mn) of the
binder is 2.0 or less, and the microporous membrane has a film thickness of 10-30 micrometers and a porosity of 40 to 60%.

US Pat. No. 9,771,519

LIQUID CRYSTAL DISPLAY ELEMENT AND METHOD FOR MANUFACTURING SAME

JNC CORPORATION, Tokyo (...

1. A liquid crystal display device, comprising
a pair of substrates arranged opposite to each other,
an electrode group disposed on one side or both sides of the pair of substrates facing each other,
a plurality of active devices connected to the electrode group,
a liquid crystal alignment film disposed on each facing side of the pair of substrates, and
a liquid crystal layer between the pair of substrates,
wherein the liquid crystal alignment film is manufactured by irradiating linearly polarized light to a film obtained from
polyamic acid or a derivative thereof having a photoisomerization structure in the main chain, and

the liquid crystal layer comprises a liquid crystal composition having negative dielectric anisotropy and including at least
one of liquid crystal compounds represented by Formula 1 as a first component:


wherein R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkenyl
having 2 to 12 carbons, where arbitrary hydrogen is replaced by fluorine;

ring A and ring B are independently 1,4-cyclohexylene, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, 1,4-phenylene, 2-fluoro-1,4-phenylene,
2,5-difluoro-1,4-phenylene, 2,3-difluoro-1,4-phenylene, 2-fluoro-3-chloro-1,4-phenylene, 2,3-difluoro-6-methyl-1,4-phenylene,
2,6-naphthalenediyl, or 7,8-difluorochroman-2,6-diyl, and at least one of ring A and ring B is 2,3-difluoro-1,4-phenylene,
2-fluoro-3-chloro-1,4-phenylene, 2,3-difluoro-6-methyl-1,4-phenylene, or 7,8-difluorochroman-2,6-diyl;

Z? is independently a single bond, —(CH2)2—, —CH2O—, —COO—, or —CF2O—;

j is 1, 2, or 3; and
the polyamic acid or the derivative thereof having a photoisomerization structure is polyamic acid or a derivative thereof
obtained by reacting tetracarboxylic dianhydride represented by AN-4-17 and at least one of a tetracarboxylic dianhydride
or a diamine having a photoisomerization structure selected from Formulae (I) to (VII):


wherein, in Formula (AN-4-17), m is an integer of 4 to 12,
R2—C?C—R3  (I)

R2—C?C—C?C—R3  (II)

R2—C?C—CH?CH—R3  (III)

R2—C?C—R4—C?C—R3  (IV)

R2—C?C—R4—CH?CH—R3  (V)

R2—CH?CH—R3  (VI)

R2—N?N—R3  (VII)

wherein, in Formulae (I) to (VII), R2 and R3 are independently a monovalent organic group having —NH2 or —CO—O—CO—, and R4 is a divalent organic group including an aromatic ring.

US Pat. No. 9,738,692

PROCESS FOR PRODUCTION OF RECOMBINANT PROTEINS AS A SOLUBLE FORM

JNC CORPORATION, Tokyo (...

1. A fusion protein that can be expressed as a soluble protein, comprising:
(1) a first amino acid sequence comprising the amino acid sequence of a polypeptide that is represented by the formula (Z)n,

wherein n represents an integer from 1 to 5 and Z represents polypeptide selected from the group of:
(a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1,
(b) a polypeptide comprising an amino acid sequence that has at least 95% identity with the amino acid sequence of SEQ ID
NO: 1, and

(c) a polypeptide comprising an amino acid sequence that has at least 98% identity with the amino acid sequence of SEQ ID
NO: 1,

and that has the capacity when expressed as a fusion protein with a target protein to render said fusion protein expressible
as a soluble protein; and

(2) a second amino acid sequence comprising the amino acid sequence of a target protein,
wherein the fusion protein further comprises, on the amino terminal side of the first amino acid sequence, an amino acid sequence
that facilitates purification, and;

wherein the expression of the fusion protein comprising the amino acid sequence that facilitates purification, an amino acid
sequence of the polypeptide that is represented by the formula (Z)n and an amino acid sequence of the target protein is induced in Escherichia coli, and the fusion protein accumulates within the Escherichia coli as a soluble protein so that the fusion protein collected from within the Escherichia coli has higher solubility rate than non-(Z)n fusion protein; and

wherein the amino acid sequence that facilitates the purification is a histidine tag sequence; and
wherein the target protein is at least one selected from the group of apoaequorin, Gaussia luciferase, and Oplophorus luciferase.

US Pat. No. 9,738,831

OPTICALLY ISOTROPIC LIQUID CRYSTAL COMPOSITION AND OPTICAL DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that exhibits an optically isotropic liquid crystal phase and contains a chiral agent and
an achiral component T containing at least one compound 1 represented by formula (1):

wherein in formula (1), R? is hydrogen or methyl;
L1, L2, L3, L4, L5, L6, L7 and L8 are each independently hydrogen or fluorine;

Z1, and Z3 are each independently a single bond, —COO— or —CF2O—, and at least one of Z1, Z2 and Z3 is —COO— or —CF2O—;

n1 and n2 are each independently 0 or 1; and
X1 is hydrogen, halogen, —SF5 or alkyl having 1 to 10 carbons, and at least one of —CH2— in the alkyl may be replaced by —O—, —S—, —COO— or —OCO—, at least one of —CH2—CH2— in the alkyl may be replaced by —CH?CH—, —CF?CF— or —C?C—, and at least one of hydrogen in the alkyl may be replaced by
fluorine or chlorine, however, a case where —O— and —CH?CH—, and —CO— and —CH?CH— are adjacent in X1 is excluded.

US Pat. No. 9,756,722

TRANSPARENT ELECTROCONDUCTIVE FILM

JNC CORPORATION, Tokyo (...

1. A transparent electro conductive film, comprising:
a transparent substrate formed of a film-like polymeric resin;
a first hard coat layer laminated on one side of the substrate; and
a first transparent conductive layer laminated on the upper side of the first hard coat layer;
wherein the substrate has a thickness of 2 to 250 ?m,
wherein the first hard coat layer is formed of an ultraviolet curable resin containing an inorganic oxide and has a thickness
of 0.36 ?m or greater and less than 0.5 ?m, and

wherein the first transparent conductive layer is formed of at least one selected from the group consisting of inorganic oxides,
metals and carbon, has a thickness of 10 nm to 2 ?m, and has been patterned to form and thereby include patterned portions
and non-patterned portions.

US Pat. No. 9,714,382

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition having a negative dielectric anisotropy and contains at least one compound selected from the
group of compounds represented by formula (1) as a first component and further containing at least one compound selected from
the group of compounds represented by formula (2) as a second component:

wherein, in formula (1), R1 and R2 are independently alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkenyloxy
having 2 to 12 carbons, or alkyl having 1 to 12 carbons in which at least one of hydrogen is replaced by fluorine or chlorine;
ring V is 1,4-cyclohexylene or tetrahydropyran-2,5-diyl; ring A and ring C are independently 1,4-cyclohexylene, tetrahydropyran-2,5-diyl,
1,4-phenylene, or 1,4-phenylene in which at least one of hydrogen is replaced by fluorine or chlorine; ring B is 2,3-difluoro-1,4-phenylene,
2-chloro-3-fluoro-1,4-phenylene, 2,3-difluoro-5-methyl-1,4-phenylene, 3,4,5-trifluoronaphthalene-2,6-diyl or 7,8-difluorochroman-2,6-diyl;
Z0, Z1 and Z2 are independently a single bond, ethylene, butene, carbonyloxy or methyleneoxy, wherein, at least one of Z0, Z1 and Z2 is butene; k is 0, 1 or 2; m is 0 or 1; and a sum of k and m is 2 or less;

in formula (2), R3 and R4 are independently alkyl having 1 to 12 carbons, alkenyl having 2 to 12 carbons, alkyl having 1 to 12 carbons in which at least
one of hydrogen is replaced by fluorine or chlorine, or alkenyl having 2 to 12 carbons in which at least one of hydrogen is
replaced by fluorine or chlorine; ring D and ring E are independently 1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene
or 2,5-difluoro-1,4-phenylene; Z3 is a single bond, ethylene or carbonyloxy; and n is 1, 2 or 3.

US Pat. No. 9,714,210

LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition that has a negative dielectric anisotropy, and contains a polymerizable compound that is at
least one compound selected from the group of compounds represented by formula (1):

wherein, in formula (1), ring A1 or ring C1 is independently cyclohexyl, cyclohexenyl, phenyl, 1-naphthyl, 2-naphthyl, tetrahydropyran-2-yl, 1,3-dioxane-2-yl, pyrimidine-2-yl
or pyridine-2-yl, and in the rings, at least one of hydrogen may be replaced by halogen, alkyl having 1 to 12 carbons, or
alkyl having 1 to 12 carbons in which at least one of hydrogen is replaced by halogen; ring B1 is 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, naphthalene-1,2-diyl, naphthalene-1,3-diyl, naphthalene-1,4-diyl,
naphthalene-1,5-diyl, naphthalene-1,6-diyl, naphthalene-1,7-diyl, naphthalene-1,8-diyl, naphthalene-2,3-diyl, naphthalene-2,6-diyl,
naphthalene-2,7-diyl, tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, pyrimidine-2,5-diyl or pyridine-2,5-diyl, and in the
rings, at least one of hydrogen may be replaced by halogen, alkyl having 1 to 12 carbons, or alkyl having 1 to 12 carbons
in which at least one of hydrogen may be replaced by halogen; Z1 or Z2 is independently a single bond or alkylene having 1 to 10 carbons, in the alkylene, at least one of —CH2— may be replaced by —O—, —CO—, —COO— or —OCO—, at least one of —CH2—CH2— may be replaced by —CH?CH—, —C(CH3)?CH—, —CH?C(CH3)— or —C(CH3)?C(CH3)—, and in the groups, at least one of hydrogen may be replaced by fluorine or chlorine; at least one of P1, P2 and P3 is acryloyloxy or methacryloyloxy, and at least one remainder is 2-butenoyloxy, 2-methyl-2-butenoyloxy, 2-methylenebutanoyloxy,
2-methyl-1-propenyloxy, 2,2-difluorovinyloxy, 2-butenyloxy, 2-methyl-2-butenyloxy or 2-methyl-2-propenyloxy; Sp1, Sp2 or Sp3 is independently a single bond or alkylene having carbons 1-10, in the alkylene, at least one of —CH2— may be replaced by —O—, —COO—, —OCO— or —OCOO—, at least one of —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and in the groups, at least one of hydrogen may be replaced by fluorine or chlorine;
a is 0, 1 or 2; and b, c or d is independently an integer from 0 to 4, and a sum of b, c, and d is 2 or more.

US Pat. No. 9,701,904

OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition, comprising an achiral component T and a chiral dopant and exhibiting an optically isotropic
liquid crystal phase, wherein the achiral component T contains, as a first component, at least one compound represented by
formula (1),
wherein R1 is alkyl having 1 to 12 carbons, alkenyl having 2 to 12 carbons, or alkoxy having 1 to 11 carbons; ring A1 and ring A2 independently represent one of the following formulae;
Z1, Z2 and Z3 are independently a single bond, —(CH2)2—, —COO—, —CF2O—, or —CH?CH—; X1 is hydrogen, halogen, —CF3, —OCF3, or —C?N; L1, L2, L3 and L4 are independently hydrogen or halogen; and i is 0, 1 or 2, and
the chiral dopant comprises at least one compound selected from the group consisting of compounds represented by formulae
(K1) to (K7),

wherein each RK is independently hydrogen, halogen, —C?N, —N?C?O, —N?C?S, or alkyl having 1 to 20 carbons, wherein at least one —CH2— in RK is optionally replaced with —O—, —S—, —COO—, or —OCO—, at least one —CH2—CH2— in RK is optionally replaced with —CH?CH—, —CF?CF— or —C?C—, and at least one hydrogen in RK is optionally replaced with halogen; each A is independently an aromatic or non-aromatic three- to eight-membered ring, or
a fused ring having 9 or more carbons, wherein at least one hydrogen in these rings is optionally replaced with halogen, alkyl
having 1 to 3 carbons or haloalkyl having 1 to 3 carbons, —CH2— in the rings is optionally replaced with —O—, —S— or —NH—, and —CH? in the rings is optionally replaced with —N?; each B
is independently hydrogen, halogen, alkyl having 1 to 3 carbons, haloalkyl having 1 to 3 carbons, an aromatic or non-aromatic
three- to eight-membered ring, or a fused ring having 9 or more carbons, wherein at least one hydrogen in these rings is optionally
replaced with halogen, alkyl having 1 to 3 carbons or haloalkyl having 1 to 3 carbons, —CH2— in the rings is optionally replaced with —O—, —S— or —NH—, and —CH? in the rings is optionally replaced with —N?; each Z
is independently a single bond, or alkylene having 1 to 8 carbons, wherein at least one —CH2— in Z is optionally replaced with —O—, —S—, —COO—, —OCO—, —CSO—, —OCS—, —N?N—, —CH?N— or —N?CH—, at least one —CH2—CH2— in Z is optionally replaced with —CH?CH—, —CF?CF— or —C?C—, and at least one hydrogen in Z is optionally replaced with halogen;
X is a single bond, —COO—, —OCO—, —CH2O—, —OCH2—, —CF2O—, —OCF2—, or —CH2CH2—; and mK is an integer of 1 to 4.

US Pat. No. 9,695,456

MICROORGANISM TESTING APPARATUS, METHOD AND PROGRAM

JNC CORPORATION, Tokyo (...

1. A microorganism testing apparatus, comprising:
a pre-processing unit in which, if a content of microorganism testing on a specific specimen is selected or input, testing
conditions of the specific specimen read from a storage device in which testing information specifying the testing conditions
of the specimen is stored are printed on a sheet-form medium to be used for testing of the specific specimen; and

a post-processing unit in which, if an image of the medium is read, the testing conditions printed on the medium and a type
of the medium preliminarily labelled on the medium are acquired from the image to output judgment results as to whether or
not the testing conditions acquired from the image, and the type of the medium are compatible.

US Pat. No. 9,659,678

METHOD FOR REMOVING CESIUM IONS FROM WATER

JNC Corporation, Chiyoda...

1. A method for removing cesium ions in an aqueous solution, comprising:
adding an aqueous solution of a substance having a cesium ion adsorption capacity to a cesium-containing aqueous solution,
the aqueous solution of the substance having a cesium ion adsorption capacity comprising a dissolved water-soluble ferrocyanide,
a dissolved water-soluble iron salt, and an alkali; while maintaining a temperature of 20 to 100° C.; whereby cesium ions
are adsorbed by the substance to form a cesium ion-containing magnetic particle; and

(i) magnetically separating the magnetic particle from the aqueous solution; or
(ii) passing the aqueous solution through a filter to separate the magnetic particle from the aqueous solution.

US Pat. No. 9,643,924

PIPERIDINE DERIVATIVE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A liquid crystal composition, containing at least one compound selected from the group of compounds represented by formula
(1), and at least one compound represented by formulas (2) to (4):
wherein, in formula (1),
R1, R2, R3, R4, R5, R6, R7 and R8 are independently hydrogen or alkyl having 1 to 4 carbons;

ring A1 and ring A2 are independently cyclohexylene, cyclohexenylene, decahydronaphthalenediyl, dihydropyrandiyl, tetrahydropyrandiyl, dioxanediyl,
phenylene, naphthalenediyl, pyrimidinediyl or pyridinediyl, and in the rings, at least one of hydrogen may be replaced by
halogen, alkyl having 1 to 5 carbons, alkoxy having 1 to 5 carbons, or alkyl having 1 to 5 carbons in which at least one of
hydrogen is replaced by halogen;

Z1, Z2 and Z3 are independently a single bond or alkylene having 1 to 10 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —S—, —CO—, —COO—, —OCO— or —SiH2—, at least one of —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and in the groups, at least one of hydrogen may be replaced by halogen; and

a and b are independently 1 or 2, and c is 0, 1 or 2;
wherein, in formulas (2) to (4),
R11 and R12 are independently alkyl having 1 to 10 carbons or alkenyl having 2 to 10 carbons, and in the alkyl or the alkenyl, at least
one of —CH2— may be replaced by —O—, and at least one of hydrogen may be replaced by fluorine;

ring B1, ring B2, ring B3 and ring B4 are independently 1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 2,5-difluoro-1,4-phenylene or pyrimidine-2,5-diyl;
and

Z11, Z12 and Z13 are independently a single bond, —CH2CH2—, —CH?CH—, —C?C— or —COO—.

US Pat. No. 9,645,128

SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES FOR MEASURING A TRANSCRIPTION ACTIVITY

JNC CORPORATION, Tokyo (...

1. A method for measuring a transcription activity or detecting an analyte, which method comprises using a luciferase derived
from a species of Renilla, Oplophorus or Gaussia and a compound represented by formula (1):
wherein:
R1 is (a) hydrogen, (b) hydroxy, (c) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic
group, or (d) trifluoromethyl;

R2 is (a) hydrogen, (b) hydroxy, (c) a halogen, (d) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with
an alicyclic group, (e) trifluoromethyl, or (f) an alkoxy;

R3 is (a) hydrogen, (b) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic group, or (c)
an alkoxy;

R4 is a substituted or unsubstituted benzyl;

R5 is (a) hydrogen or (b) a substituted or unsubstituted alkyl;

X1 is (a) hydrogen or (b) hydroxy; and

X2 is (a) hydrogen or (b) hydroxy;

with the proviso that when R2 and R3 are hydrogen, R1 is (a) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic group or (b) trifluoromethyl,

when R1 and R3 are hydrogen, R2 is (a) hydroxy, (b) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic group, (c) trifluoromethyl,
or (d) an alkoxy, and

when R1 and R2 are hydrogen, R3 is (a) an alkyl having 1 to 4 carbon atoms which may optionally be substituted with an alicyclic group or (b) an alkoxy.

US Pat. No. 9,663,717

LIQUID CRYSTAL COMPOUND HAVING CYCLOHEXENE RING, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein, in formula (1),
R1 is hydrogen, fluorine, chlorine or alkyl having 1 to 10 carbons, and in R1, at least one piece of —CH2— may be replaced by —O—, at least one piece of —CH2CH2— may be replaced by —CH?CH—, and at least one piece of hydrogen may be replaced by fluorine;

ring A1, ring A3 and ring A4 are independently 1,4-cyclohexylene, 1,4-phenylene, 1,4-phenylene in which at least one piece of hydrogen is replaced by fluorine,
tetrahydropyran-2,5-diyl, 1,3-dioxane-2,5-diyl, pyridine-2,5-diyl or pyrimidine-2,5-diyl, and ring A2 is a divalent group represented by any one of formula (Ch), formula (Cx) and formula (ch);

wherein, Z1, Z2, Z3 and Z4 are independently a single bond, —COO—, —OCH2—, —CF2O—, —CH2CH2—, —CH?CH—, —C?C—, —CF2CF2—, —CF?CF—, —(CH2)4— or —CH2CH?CHCH2—;
X1 is hydrogen, fluorine, —CF3 or —OCF3;

L1 and L2 are independently hydrogen or fluorine; and

a, b and c are independently 0 or 1, and a sum of a, b and c is 0 or 1.

US Pat. No. 9,631,142

PIPERIDINE DERIVATIVE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by any of formulas (1-1) to (1-4):

wherein, in formulas (1-1) to (1-4),
M is aliphatic hydrocarbon group having 1 to 20 carbons or aromatic hydrocarbon group having 1 to 20 carbons, and in the groups,
at least one —CH2— may be replaced by —O— or —S—, one or two —CH?CH— may be replaced by —CH?N—, and at least one of hydrogen may be replaced
by fluorine or chlorine;

Z is a single bond, —O—, —COO—, or —OCO—;
Q is a monovalent group represented by formula (Q-1), (Q-2) or (Q-3), in which Ra is hydrogen, —O., —OH, or —R1;


Rb is hydrogen, fluorine or —R2;

R1 and R2 are independently an alkyl having 1 to 20 carbons, arylalkyl having 1 to 20 carbons, or aryl having 1 to 20 carbons, and in
the alkyl, at least one —CH2— may be replaced by —O—, —CO—, —COO—, or —OCO—, and —CH3 located at a terminal may be replaced by —NHR3 or —NR4R5, in which R3, R4, and R5 are independently alkyl having 1 to 10 carbons.

US Pat. No. 9,537,110

CHALCOGEN-CONTAINING ORGANIC COMPOUND AND USE THEREOF

JNC CORPORATION, Tokyo (...

1. A compound of formula (1-1) or formula (1-2):

wherein, in formula (1-1) and formula (1-2),
X is oxygen, sulfur or selenium;
each n is independently 0 or 1;
each R3 is independently fluorine, alkyl having 1 to 20 carbons, aryl, pyridyl, furyl, thienyl or thiazolyl, optionally one or more
hydrogens in the alkyl is replaced by fluorine, and optionally one or more hydrogens on a ring of the aryl, the pyridyl, the
furyl, the thienyl and the thiazolyl is replaced by at least one selected from the group consisting of halogen and alkyl having
1 to 10 carbons.

US Pat. No. 9,523,036

PHENOLIC COMPOUND HAVING CARBONYL AS NEIGHBORING GROUP AND APPLICATION THEREOF

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):

wherein, in formula (1),
R1 and R2 are independently alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, at least one of —(CH2)2— may be replaced by —CH?CH—, and at least one of hydrogen may be replaced by halogen;

ring A1 and ring A2 are independently 1,4-cyclohexylene or 1,4-phenylene, at least one of —(CH2)2— constituting 1,4-cyclohexylene may be replaced by —CH?CH—, at least one of


constituting 1,4-cyclohexylene may be replaced by

at least one of —CH2— constituting 1,4-cyclohexylene may be replaced by —O— or

—CO—, and at least one of hydrogen directly bonded with the rings may be replaced by halogen, —CF3, —CF2H or —CH2F;

Z1 is a single bond, —(CH2)2—, —CH2O—, —OCH2—, —CF2O—, —OCF2—, —COO— or —OCO—;

Y is fluorine, chlorine, —CF3, —CF2H or —CH2F; and

m, n and p are independently 0, 1 or 2, and
a sum (m+n) of m and n is 0, 1 or 2.

US Pat. No. 9,523,038

DIHYDROPYRAN COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by formula (1):
wherein, in formula (1),
Ra and Rb are independently hydrogen or alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, at least one of —CH2CH2— may be replaced by —CH?CH— or —C?C—, and in the monovalent groups, at least one of hydrogen may be replaced by fluorine
or chlorine, and Rb may be fluorine, chlorine, —C?N, or —C?C—C?N;

A1, A2 and A3 are independently 1,4-cyclohexylene, decahydronaphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl, 2,6,7-trioxabicyclo[2.2.2]octane-1,4-diyl,
1,4-phenylene, naphthalene-2,6-diyl, 9,10-dihydrophenanthrene-2,7-diyl, 9H-xanthene-2,6-diyl or fluorene-2,7-diyl, and in
the groups, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, at least one of —CH2—CH2— may be replaced by —CH?CH— or —CH?N—, and in the divalent groups, at least one of hydrogen may be replaced by fluorine,
chlorine, —C—N, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F;

G is a divalent group represented by formula (pr-1) or (pr-2);
wherein,
Z1, Z2 and Z3 are independently a single bond or alkylene having 1 to 6 carbons, and in the alkylene, at least one of —CH2— may be replaced by —O—, —S—, —CO— or —SiH2—, at least one of —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and in the divalent groups, at least one of hydrogen may be replaced by fluorine or
chlorine;

a and b are independently 0, 1, 2 or 3, and a sum of a and b is 4 or less; and
when Ra is —C5H11, Rb is —OC2H5, A3 is 2,3-difluorophenylene, Z3 is a single bond, and a and b are 0, G is a divalent group represented by formula (pr-1).

US Pat. No. 9,796,927

LIQUID CRYSTAL ALIGNING AGENTS FOR FORMING PHOTO-ALIGNING LIQUID CRYSTAL ALIGNMENT LAYERS, LIQUID CRYSTAL ALIGNMENT LAYERS AND LIQUID CRYSTAL DISPLAY DEVICES USING THE SAME

JNC CORPORATION, Tokyo (...

1. A photo-aligning liquid crystal aligning agent containing a polyamic acid or derivative thereof having a photoreactive
structure originating in at least one of a tetracarboxylic acid dianhydride having a photoreactive structure and a diamine
having a photoreactive structure in a structural unit,
wherein the polyamic acid or derivative thereof is synthesized by using a tetracarboxylic acid dianhydride having no photoreactive
structure and a diamine having no photoreactive structure together with at least one of the tetracarboxylic acid dianhydride
having a photoreactive structure and the diamine having a photoreactive structure;

the tetracarboxylic acid dianhydride having no photoreactive structure comprises at least one compound represented by the
following Formula (AN-b);

the diamine having no photoreactive structure comprises at least one selected from the group of compounds represented by the
following Formulas (DI-a) to (DI-c):


wherein
in Formula (AN-b), X2 is an alkylene having 4 to 8 carbon atoms;

in Formula (DI-b), R1 is hydrogen or —CH3, and a is an integer of 1 to 5; and

in Formulas (DI-a) and (DI-b), groups in which bonding positions are not fixed to any of carbon atoms constituting the rings
show that the bonding positions thereof in the rings are optional.

US Pat. No. 9,777,219

LIQUID CRYSTAL COMPOUND HAVING TETRACYCLE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A compound represented by any one of formulas (1a), (1b) or (1c):
wherein, in formulas (1a), (1b) and (1c),
R1 is alkyl having 1 to 10 carbons, alkoxy having 1 to 10 carbons, alkenyl having 2 to 10 carbons or alkenyloxy having 2 to 10
carbons;

Z1, Z2 and Z3 are independently a single bond, —COO—, —OCH2, —CH2CH2—, —CF2CF2—, —CF?CF—, —C?C—, —(CH2)4— or —CH2CH?CHCH2—, and Z1 and Z3 may be independently —CH?CH—;

X1 is fluorine, —CF3 or —OCF3; and

L1, L2, L3 and L4 are independently hydrogen, fluorine or chlorine;

in which, in formula (1a), when Z1 and Z2 are a single bond, R1 is alkoxy having 1 to 10 carbons or alkenyl having 2 to 10 carbons.

US Pat. No. 9,741,950

POLYCYCLIC AROMATIC COMPOUND

KYOTO UNIVERSITY, Kyoto ...

1. A polycyclic aromatic compound or a salt thereof represented by the following formula (I):

wherein
X represents B, P, P?O, P?S, P?Se, As, As?O, As?S, As?Se, Sb, Sb?O, Sb?S, Sb?Se, an optionally substituted metal in groups
3 to 11 in the periodic table, or an optionally substituted metal or metalloid in group 13 or 14 of the periodic table; and

ring A, ring B, ring C, and ring D are the same or different, and each represents an optionally substituted phenyl ring, an
optionally substituted phenyl ring fused to an aryl or heteroaryl ring, an optionally substituted heteroaromatic ring, or
an optionally substituted heteroaromatic ring fused to an aryl or heteroaryl ring,

wherein at least one of ring A, ring B, ring C, and ring D is an optionally substituted heteroaromatic ring, or an optionally
substituted heteroaromatic ring fused to an aryl or heteroaryl ring,

wherein the heteroaromatic ring of ring A, ring B, ring C, and ring D is selected from the group consisting of thiophene,
pyrrole and pyridine, and

wherein the compound represented by formula (I) is not a heterofullerene.
US Pat. No. 9,765,381

MUTATED GENES FOR THE CATALYTIC PROTEIN OF OPLOPHORUS LUCIFERASE AND USE THEREOF

JNC CORPORATION, Tokyo (...

1. A method for assaying the transcription activity of a promoter-containing polynucleotide sequence, which comprises using
a polynucleotide encoding a luciferase mutant as a reporter gene, wherein the polynucleotide encoding the luciferase mutant
is operably fused to the promoter-containing polynucleotide sequence, wherein the luciferase mutant expressed is contacted
with a luciferin, and wherein the luciferase mutant is selected from (a) to (e) below:
(a) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2;

(b) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 is an amino acid sequence in which 1 to 17 amino acids are deleted, substituted, inserted
and/or added in the amino acid sequence at the positions of 5 to 169 of SEQ ID NO: 2, and having a luciferase activity;

(c) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 has at least 90% identity to the amino acid sequence at the positions of 5 to 169 of SEQ
ID NO: 2, and having a luciferase activity;

(d) a luciferase mutant consisting of an amino acid sequence in which at least one amino acid selected from amino acids at
the positions of 1 to 4 is deleted in the amino acid sequence of SEQ ID NO: 2 and an amino acid sequence excluding the amino
acids at the positions of 1 to 4 is encoded by a polynucleotide which hybridizes under high stringent conditions to a polynucleotide
consisting of a nucleotide sequence complementary to a nucleotide sequence encoding the amino acid sequence at the positions
of 5 to 169 of SEQ ID NO: 2, wherein the high stringent conditions are 5×SSC, 5×Denhart's solution, 0.5% (w/v) SDS, 50% (v/v)
formamide and 50° C., and having a luciferase activity; and,

(e) a luciferase mutant consisting of an amino acid sequence selected from SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8 and SEQ
ID NO: 10.

US Pat. No. 9,753,186

GLASS FIBER-SILSESQUIOXANE COMPOSITE MOLDED ARTICLE AND METHOD FOR PRODUCING SAME

JNC CORPORATION, Tokyo (...

1. A glass cloth-silsesquioxane composite molded article, comprising:
a glass cloth; and
a cured product of silsesquioxane polymer that forms a composite with the glass cloth,
wherein the silsesquioxane has a cage structure or partial cage structure,
wherein the glass cloth-silsesquioxane composite molded article is obtained by impregnating the glass cloth with a composition
containing at least one silsesquioxane having a polymerizable functional group represented by formula (A-3), and a curing
agent, or a polymerization initiator,

and subjecting the resultant to a curing reaction:
wherein in the formula (A-3),
R independently represents hydrogen; an alkyl having 1 to 45 carbon atoms in which any hydrogen may be substituted by fluorine
and nonadjacent —CH2— may be substituted by —O— or a cycloalkylene; a cycloalkyl having 4 to 8 carbon atoms; or an aryl in which any hydrogen
may be substituted by an alkyl having 1 to 10 carbon atoms, halogen, or fluorine;

R1 independently represents a group selected from an alkyl having 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, and phenyl; and
at least one of X represents an alkyl having 1 to 10 carbon atoms having a polymerizable functional group, a cycloalkyl having
a polymerizable functional group, or a phenyl having a polymerizable functional group, and the remainder of X represents a
group defined in the same manner as R1,

wherein the polymerizable functional group of X is selected from group represented by the formulas (d) and (e)
wherein, R2 represents an alkylene having 1 to 10 carbon atoms, one —CH2— in the alkylene may be substituted by —O— or 1,4-phenylene; and R3 represents hydrogen or an alkyl having 1 to 6 carbon atoms.

US Pat. No. 9,637,578

POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A polymerizable compound represented by formula (1):

wherein, in formula (1),
P1 and P2 are independently a polymerizable group;

S1 and S2 are independently a single bond or alkylene having 1 to 10 carbons, in the alkylene, at least one of —CH2— may be replaced by —O—, —CO—, —COO— or —OCO—, at least one of —CH2—CH2— may be replaced by —CH?CH— or —C?C—, and in the divalent groups, at least one of hydrogen may be replaced by halogen or
alkyl having 1 to 3 carbons;

R4 is hydrogen or —S1—P1, and R5 is hydrogen or —S2—P2;

a1 and a2 are independently 0, 1, 2, 3 or 4; and
a total of —S1—P1 and —S2—P2 is 2 to 8, and at least one of all of —S1—P1 and all of —S2—P2 is a monovalent group represented by formula (A):


wherein, in formula (A), R1 and R2 are independently alkyl having 1 to 3 carbons, and R3 is hydrogen or methyl; and

in formula (1),
ring A1 and ring A2 are independently a divalent group derived from alicyclic hydrocarbon having 3 to 18 carbons, aromatic hydrocarbon having
6 to 18 carbons or heteroaromatic hydrocarbon having 3 to 18 carbons, in the divalent groups, at least one of hydrogen may
be replaced by halogen, alkyl having 1 to 12 carbons, alkoxy having 1 to 12 carbons, alkenyl having 1 to 12 carbons or alkenyloxy
having 1 to 12 carbons, and in the monovalent hydrocarbon groups, at least one of hydrogen may be replaced by halogen;

Z1 is a single bond or alkylene having 1 to 10 carbons, in the alkylene, at least one of —CH2— may be replaced by —O—, —CO—, —COO— or —OCO—, at least one of —CH2—CH2— may be replaced by —CH?CH—, —C(CH3)?CH—, —CH?C(CH3)—, —C(CH3)?C(CH3)— or —CH?CH—, and in the divalent groups, at least one of hydrogen may be replaced by halogen; and

b1 is 0, 1, 2 or 3.