US Pat. No. 9,070,006

METHOD AND SYSTEM FOR PROCESSING AN IMAGE OF A BIOLOGICAL SPECIMEN

Hologic, Inc., Marlborou...

1. A method of processing an image of a biological specimen, the specimen having a plurality of cells, the method comprising:
identifying nucleoli of the cells of the biological specimen in the image based on spectral characteristics of the nucleoli;
and
using a processor to evaluate one or more physical characteristics of the nucleoli in order to determine whether cells having
the nucleoli have a likelihood of being cancerous or non-cancerous.

US Pat. No. 9,415,239

BRACHYTHERAPY DEVICE FOR FACILITATING ASYMMETRICAL IRRADIATION OF A BODY CAVITY

HOLOGIC, INC., Marlborou...

1. A brachytherapy device for treating tissue surrounding a body cavity within a patient, comprising:
a. an elongated shaft having a longitudinal axis and a distal shaft portion, and having a plurality of tubular members that
extend along the distal shaft portion, the distal shaft portion being configured to be deployed within the body cavity, the
plurality of tubular members being configured to be radially off-set from the longitudinal axis at the distal shaft portion
to facilitate asymmetric irradiation of the body cavity when the distal shaft portion is deployed within the body cavity,
wherein the plurality of tubular members are configured to selectively and individually expand away from the distal shaft
portion; and

b. an expandable member coupled to the elongated shaft to define an expandable volume around the distal shaft portion, and
wherein the expandable member is configured to be spaced apart from plurality of tubular members when the plurality of tubular
members are expanded.

US Pat. No. 9,248,311

SYSTEM AND METHOD FOR MODIFYING A FLEXIBILITY OF A BRACHYTHEREAPY CATHETER

Hologic, Inc., Bedford, ...

1. An apparatus for treating a proliferative disorder in a patient comprising:
an implantable rigid member having a proximal end and a distal end, the implantable rigid member comprising a plurality of
lumen openings extending longitudinally within the implantable rigid member, and wherein the proximal end of the implantable
rigid member defines a lock opening;

a plurality of separate flexible dosing lumens, each having a proximal end and a distal end, wherein each distal end of each
dosing lumen extends into a different one of the plurality of lumen openings of the implantable rigid member and wherein the
distal end of each dosing lumen is spaced apart from the proximal end of the implantable rigid member;

a hub discrete from the implantable rigid member and disposed about the plurality of dosing lumens, wherein the hub defines
a slot defined by an outer circumferential surface of the hub; and

a stylet comprising a shaft having a distal end and a proximal end and a key feature at the distal end of the shaft, wherein
an exterior of the shaft has a uniform shape along a length of the shaft from the proximal end of the shaft to the distal
end of the shaft and wherein the key feature removably mates with the lock opening of the implantable rigid member, and wherein
the proximal end removably mates with the slot defined by the hub, such that mating engagement between the stylet and both
the lock opening and the slot allows for a one-to-one axial rotation of the implantable rigid member and the hub, whereby
an axial rotation of the stylet causes a corresponding axial rotation of the implantable rigid member and the hub.

US Pat. No. 9,095,366

TISSUE CUTTER WITH DIFFERENTIAL HARDNESS

HOLOGIC, INC., Marlborou...

1. A uterine fibroid tissue removal device, comprising:
a housing;
an outer tube having a distal end and a proximal end, the proximal end of the outer tube supported by the housing, the outer
tube configured for transcervical insertion into a uterus and having a side opening proximate the distal end of the outer
tube;

an inner tube formed from a first material and having an axial lumen, the inner tube being disposed within the outer tube
and configured to be translated and rotated relative to the outer tube during operation of the tissue removal device; and

a unitary distal tip member formed separately from the inner tube out of a second material harder than the first material,
the distal tip member being attached to a distal end of the inner tube such that an axial lumen of the distal tip member is
in fluid communication with the inner tube axial lumen, and such that the distal tip member translates and rotates relative
to the outer tube along with the inner tube during operation of the tissue removal device, wherein a distal facing open cutting
end of the distal tip member in fluid communication with the lumen of the distal tip member translates across the side opening
of the outer tube to sever tissue extending therethrough,

wherein the axial lumen of the distal tip member is smaller in cross-sectional area than the axial lumen of the inner tube,
and

wherein the distal facing open cutting end of the distal tip member comprises an external bevel.

US Pat. No. 9,456,808

BIOPSY DEVICE WITH AUTOMATIC BIOPSY PARAMETER ADJUSTMENT

Hologic, Inc., Marlborou...

1. A biopsy system, comprising:
a support structure;
an elongate cannula coupled to and extending from the support structure, the cannula having a distal portion with a tissue
receiving aperture in a side wall thereof;

an elongate hollow introducer sized and configured to be mounted to the support structure over the cannula, wherein the support
structure and a proximal portion of the introducer are respectively configured for providing releasable attachment of the
introducer to the support structure over the cannula in a first attachment configuration, in which the distal portion of the
cannula extends out an open distal end of the introducer with the tissue receiving aperture unobscured by the introducer,
and in a second attachment configuration, in which the distal portion of the cannula extends out the open distal end of the
introducer with the tissue receiving aperture partially obscured by the introducer; and

an axially oscillating cutter disposed in an axial lumen of the cannula, wherein an oscillation stroke length of the cutter
when the introducer is attached to the support structure in the first attachment configuration is greater than an oscillation
stroke length of the cutter when the introducer is attached to the support structure in the second attachment configuration.

US Pat. No. 9,448,146

METHOD FOR AUTOMATED SPECIMEN TRANSFER

HOLOGIC, INC., Bedford, ...

1. A hybrid manual-automated method for processing samples, the method comprising:
manually providing a plurality of sample containers in a sample input, each sample container of the plurality having respective
contents comprising a respective specimen;

manually providing unused consumable supplies in a consumables input;
automatically agitating each sample container of the plurality to homogenize the respective contents thereof;
automatically removing a lid from each sample container of the plurality using an automated system;
automatically withdrawing the respective specimen from each sample container of the plurality using the automated system;
automatically transferring each respective specimen to a respective output carrier using the automated system;
automatically replacing the lid on each sample container of the plurality using the automated system;
automatically conveying each respective output carrier to a sample output location using the automated system; and
manually removing each respective output carrier from the sample output location,
wherein agitating each sample container of the plurality to homogenize the contents thereof comprises rotating a respective
agitator in the sample container.

US Pat. No. 9,164,092

DETECTION OF INTRAAMNIOTIC INFECTION

Hologic, Inc., Marlborou...

1. A method for the diagnosis of intra-amniotic inflammation or infection in a pregnant female mammalian subject comprising:
(a) measuring in a sample of cervical-vaginal fluid obtained from said subject the levels of interleukin-6 (IL-6) and fetal
fibronectin (fFN) relative to the corresponding levels of said proteins in normal cervical-vaginal fluid or cervical-vaginal
fluid known to be indicative of intra-amniotic inflammation or infection; and

(b) diagnosing said subject with intra-amniotic inflammation or infection if each of said levels of each of said proteins
in said sample is determined to show a statistically significant difference relative to the corresponding levels of each of
said proteins in said normal cervical-vaginal fluid, or is determined not to show a statistically significant difference relative
to the corresponding levels of each of said proteins in said cervical-vaginal fluid known to be indicative of intra-amniotic
inflammation or infection.

US Pat. No. 9,075,903

USER INTERFACE FOR MEDICAL IMAGE REVIEW WORKSTATION

HOLOGIC, INC., Marlborou...

1. A computer-implemented method for controlling display of medical images, the method comprising:
displaying or invoking for display, on a screen of a mobile communication device of a user, a first touchscreen interface
for controlling display of a selected medical image, the first touchscreen interface comprising a plurality of interface elements;

detecting the user tapping the screen with a plurality of fingers simultaneously;
displaying or invoking for display, on the screen, a second touchscreen interface for controlling display of the selected
medical image, the second touchscreen interface consisting of a subset of the plurality of the interface elements of the first
touchscreen interface;

determining a second medical image selected by the user;
determining a third touchscreen interface different than the second touchscreen interface for controlling display of the second
medical image;

displaying or invoking for display, on the screen, the third touchscreen interface comprising a plurality of interface elements;
detecting a further instance of the user tapping the screen with a same or different plurality of fingers simultaneously;
displaying or invoking for display, on the screen, a fourth touchscreen interface for controlling display of the second medical
image, the fourth touchscreen interface consisting of a subset of the plurality of the interface elements of the third touchscreen
interface.

US Pat. No. 9,301,770

SYSTEMS, METHODS AND DEVICES FOR PERFORMING GYNECOLOGICAL PROCEDURES

HOLOGIC, INC., Marlborou...

1. A system for occluding a body lumen, comprising:
an elongate delivery device configured for insertion into a body lumen; and
a tissue engaging device configured for insertion within a body lumen using the elongate delivery device, the tissue engaging
device including a distal element slidably coupled with a proximal element, the distal element having a proximally extending
shaft that mates with a locking mechanism of the proximal element,

a proximal facing outer surface of the distal element, a distal facing outer surface of the proximal element, and an outer
surface of the distal element shaft collectively defining an annular recess for receiving wall tissue of a body lumen in which
the tissue engaging device has been inserted, the annular recess having an axial length determined by a relative position
of the distal element to the proximal element,

the distal element shaft comprising a vacuum port disposed on an outer surface thereof, the vacuum port in fluid communication
with a vacuum supply lumen extending through the elongate delivery device, such that a vacuum source placed in fluid communication
with the vacuum supply lumen when the tissue engaging device is inserted in a body lumen would cause plicated wall tissue
of the body lumen to be drawn against the outer surface of the distal element shaft within the annular recess, and wherein
movement of the distal element towards the proximal element to thereby shorten the axial length of the annular recess would
apply compression to plicated wall tissue drawn into the annular recess to thereby form an occlusion of the body lumen.

US Pat. No. 9,179,873

ESTIMATING VISCERAL FAT BY DUAL-ENERGY X-RAY ABSORPTIOMETRY

Hologic, Inc., Bedford, ...

1. A dual energy x-ray absorptiometry (DXA) method for determining visceral fat of a selected sub-volume of a visceral fat
volume of a patient, which visceral fat volume is surrounded by a subcutaneous fat volume and together therewith forms a total
volume of a length of the patient's body, wherein the sub-volume also contains material that is not visceral fat, comprising:
acquiring DXA measurements for respective pixel positions of a two-dimensional DXA projection image of said total volume,
including measurements of the subcutaneous fat and the visceral fat in the total volume, thereby forming a two-dimensional
DXA image showing the subcutaneous fat and visceral fat of the length of the patient's body;

computer processing said DXA measurements as represented by said two-dimensional DXA image to determine therefrom differences
between visceral and subcutaneous fat at least in a slice of the patient's body and an estimate of visceral fat contained
in said sub-volume of the visceral fat volume that also contains material that is not visceral fat; and

providing and displaying an indication of said visceral fat estimate.

US Pat. No. 9,072,431

ACCESS SYSTEM WITH REMOVABLE OUTFLOW CHANNEL

HOLOGIC, INC., Bedford, ...

1. A method of accessing an internal site in a patient's uterus, comprising:
positioning a hysteroscope into an inserted position by inserting a distal end of the hysteroscope, from an outside of a body
of a patient, through a cervix of the patient, into a position within the patient's uterus, the hysteroscope comprising a
proximal end and an elongate body extending from the proximal end to the distal end, the elongate body having a working channel
extending axially therethrough;

fluidly connecting the working channel to an inflow fluid source for introducing inflow fluid into the patient's uterus through
the working channel;

inserting axially a removable outflow channel through the working channel, the removable outflow channel having a lumen extending
between a distal end and a proximal end of the removable outflow channel, wherein the distal end of the removable outflow
channel does not substantially extend beyond the distal end of the hysteroscope;

fluidly connecting the removable outflow channel to a vacuum source for removing inflow fluid from the patient's uterus through
the removable outflow channel;

distending the patient's uterus by introducing inflow fluid into the working channel and into the uterus;
removing the removable outflow channel from the working channel, while maintaining the hysteroscope in the inserted position
such that the distal end of the hysteroscope remains within the patient's uterus, by proximally retracting the removable outflow
channel to a first position to thereby close a seal device coupled to the proximal end of the hysteroscope, wherein the seal
device prevents inflow fluid from exiting out of the proximal end of the hysteroscope;

after removing the removable outflow channel from the working channel, advancing axially a surgical instrument through the
working channel and into the patient's uterus, the surgical instrument comprising a tissue morcellator having an internal
outflow channel; and

fluidly connecting the internal outflow channel of the morcellator to a vacuum source for removing inflow fluid from the patient's
uterus through the internal outflow channel.

US Pat. No. 9,308,017

BREAST BIOPSY LATERAL ARM SYSTEM

HOLOGIC, INC., Bedford, ...

1. An apparatus comprising:
a biopsy guidance module, the biopsy guidance module comprising a post member;
a lateral member, wherein the lateral member has a longitudinal axis, the lateral member being slidably mounted on the post
member;

a slide assembly, wherein the slide assembly is slidably mounted on the lateral member, wherein the slide assembly has a longitudinal
axis and wherein the longitudinal axis of the slide assembly is generally parallel to the longitudinal axis of the lateral
member;

a gun mount configured to support a biopsy gun, the gun mount being connected to the lateral member via the slide assembly,
wherein the gun mount is movable by sliding the slide assembly on the lateral member along a first axis with respect to the
lateral member, the first axis being along an insertion direction of the biopsy gun into a patient; and

a sensor which detects a position of the gun mount along the first axis with respect to the lateral member and generates positional
data which is provided to an interface module.

US Pat. No. 9,241,681

METHODS AND SYSTEMS FOR DYNAMICALLY MODIFYING ACQUISITION PARAMETER DURING IMAGE ACQUISITION

Hologic, Inc., Marlborou...

1. A method for acquiring a plurality of breast tissue images using an imaging system, the imaging system comprising an image
acquisition device operatively associated with a system controller, the method comprising:
acquiring a first image of the breast tissue using the image acquisition device;
processing the first image using an image processor operatively associated with the controller to determine a physical characteristic
of the breast tissue; and

acquiring ultrasound image data of the breast tissue using an operating parameter that is based upon the determined physical
characteristic of the breast tissue.

US Pat. No. 9,096,893

METHODS FOR ANALYSIS OF NUCLEIC ACID MOLECULES DURING AMPLIFICATION REACTIONS

HOLOGIC, INC., Bedford, ...

1. A method of analyzing a target nucleic acid, comprising:
a) amplifying a target nucleic acid in the presence of a synthetic probe and a thermostable FEN-1 endonuclease under conditions
such that said synthetic probe is cleaved during an amplification reaction to generate cleaved fragments;

wherein said synthetic probe is a footprint probe comprising an analyte-specific portion and a non-target portion, wherein
said non-target portion is substantially non-complementary to said target nucleic acid and wherein said analyte-specific portion
is no more than 12 nucleotides in length, and contains up to 12 nucleotides that are complementary to said target nucleic
acid, and

wherein, if said amplifying is done in an isothermal reaction, said analyte-specific portion of said footprint probe has a
calculated Tm with said target that is at least 5° C. below the temperature at which said isothermal reaction is conducted, or if said amplifying
is done in a thermal cycling reaction, said analyte-specific portion of said footprint probe has a calculated Tm with said target that is at least 5° C. below the lowest temperature used in said thermal cycling; and

b) detecting said cleaved fragments during said amplification reaction.

US Pat. No. 9,480,824

CUFF-RESISTANT ANCHORING BALLOON FOR MEDICAL DEVICE

Hologic, Inc., Bedford, ...

1. A medical device, comprising:
an elongate support structure; and
an inflatable balloon, the balloon comprising a first-end portion secured to the support structure at a first location, a
second-end portion secured to the support structure at a second location distal to the first location, and a middle-body portion,

the middle-body portion having a first end integrally formed with or otherwise bonded to the first-end portion, and a second
end integrally formed with or otherwise bonded to the second-end portion,

the first-end portion having a wall thickness greater than a wall thickness of the middle-body portion,
the respective first-end portion, middle-body portion and second-end portion collectively defining a sealed interior of the
balloon through which the support structure extends,

the balloon being stretch-mounted to the support structure so as to be in tension relative to the support structure,
wherein the balloon is formed in a diamond shaped configuration that transitions to a substantially spherical configuration
when the balloon is inflated to an inflation pressure that is at least about ten percent greater than atmospheric pressure
external to the balloon,

such that the balloon, when inflated to the inflation pressure and anchored in an anatomical body region, resists movement
of the support structure relative to the balloon.

US Pat. No. 9,352,172

USING A GUIDE MEMBER TO FACILITATE BRACHYTHERAPY DEVICE SWAP

Hologic, Inc., Bedford, ...

1. A method for facilitating brachytherapy treatment comprising the steps of:
positioning a first device such that a distal end of the first device is disposed in a resected cavity of a patient, the first
device including a shaft in which is disposed an elongated guide member such that positioning the first device simultaneously
positions the elongated guide member, the elongated guide member being configured in which all but a distal end of the elongated
guide member is configured to slide relative to the shaft within an interior of the first device, wherein the elongated guide
member includes a guide wire and a non-inflatable anchor member at a distal end of the elongated guide member, wherein the
non-inflatable anchor member has a curvature and wherein a surface tip of the shaft has an outer curvature that matches the
non-inflatable anchor member curvature, and wherein the non-inflatable anchor member curvature is disposed against the surface
tip outer curvature when loaded into the first device;

maintaining the non-inflatable anchor member without use of an inflatable device in a fixed position relative to tissue in
the resected cavity;

removing the first device from the resected cavity without removing the elongated guide member such that the fixed position
of a distal end of the elongated guide member in the resected cavity is maintained relative to the resected cavity; and

introducing the elongated guide member into an opening spanning a length of a brachytherapy catheter and using the elongated
guide member to guide the brachytherapy catheter to the resected cavity by moving the brachytherapy catheter relative to the
elongated guide member until the brachytherapy catheter envelops all but the distal end of the elongated guide member.

US Pat. No. 9,333,111

FUNDUS BUMPER MECHANICAL REFERENCE FOR EASIER MECHANISM DEPLOYMENT

Hologic, Inc., Marlborou...

1. An intrauterine ablation device, comprising:
an elongate tubular member configured for transcervical insertion;
an elongate central member slidably disposed within the elongate tubular member, the elongate central member comprising a
distal bumper; and

an energy applicator operatively coupled to the elongate tubular member, the energy applicator comprising a tissue contacting
member, and an expandable-collapsible support structure underlying the tissue contacting member, the expandable-collapsible
support structure comprising a first flexure having a first flexure distal tip and a second flexure having a second flexure
distal tip, wherein the first and second flexures are adjustable between a collapsed configuration, in which the first and
second flexure distal tips are closely apposed to the elongate central member and disposed proximally of and adjacent to the
distal bumper, and an expanded configuration in which the first and second flexure distal tips extend laterally in opposite
directions away from the elongate central member and the distal bumper;

wherein the distal bumper has an insertion profile at least as large as an insertion profile of the expandable-collapsible
support structure in the collapsed configuration,

wherein the distal bumper is distal to the first and second flexure distal tips in the collapsed configuration and is configured
to contact a fundal wall of the uterus upon distal advancement of the elongate central member relative to the elongate tubular
member within the uterus to thereby prevent the first and second flexure distal tips from engaging the fundal wall during
transition of the expandable-collapsible support structure from the collapsed configuration to the expanded configuration,
and

wherein the elongate central member and the expandable-collapsible support structure are configured to move relative to each
other along a longitudinal direction of the elongate central member so as to change a position of the distal bumper relative
to the first and second flexure distal tips.

US Pat. No. 9,084,579

MATCHING GEOMETRY GENERATION AND DISPLAY OF MAMMOGRAMS AND TOMOSYNTHESIS

HOLOGIC, INC., Bedford, ...

1. A method comprising:
imaging a breast so as to acquire digital information corresponding to a plurality of 2D x-ray tomosynthesis projection images
of the breast taken at different angles;

generating, from the digital information, a plurality of reconstructed tomosynthesis images representative of respective breast
slices;

obtaining a 2D mammogram image of the breast; and
displaying at least one of the plurality of reconstructed tomosynthesis images representative of respective breast slices
and the 2D mammogram image of the breast.

US Pat. No. 9,808,215

SYSTEM AND METHOD FOR GENERATING A 2D IMAGE FROM A TOMOSYNTHESIS DATA SET

HOLOGIC, INC., Marlborou...

1. A method for imaging breast tissue, comprising:
obtaining a plurality of tomosynthesis projection images;
processing the plurality of tomosynthesis projection images to generate a plurality of tomosynthesis reconstructed images;
analyzing a tomosynthesis data set comprising one or more of the plurality of tomosynthesis projection images and/or the plurality
of tomosynthesis reconstructed images using computer aided detection (CAD);

generating a two-dimensional synthesized mammogram from the tomosynthesis data set; and
displaying the synthesized mammogram on a display device, wherein the synthesized mammogram comprises a synthesized two-dimensional
image that simulates a conventional mammography image.

US Pat. No. 9,622,726

BIOPSY DEVICE LATCHING ASSEMBLY

Hologic, Inc., Marlborou...

1. A biopsy instrument driver, comprising:
an instrument drive member coupled to a support structure and having a laterally extending catch arm, the drive member being
movable relative to the support structure between a distal, fired position and a proximal, armed position;

a motor coupled to the support structure and having a rotatable output;
a drive shaft rotatably coupled to the support structure, the drive shaft comprising or otherwise being operatively connected
to the motor output such that activation of the motor rotates the drive shaft;

a translating member threadably coupled to the drive shaft, such that rotation of the drive shaft causes axial translation
of the translating member along the drive shaft relative to the support structure;

a latch base movably coupled to the support structure and operatively associated with the translating member; and
a latch arm movably coupled to the latch base, the latch arm having a distal portion configured to selectively engage and
retain the instrument drive member catch arm, and a proximal portion operatively coupled to the translating member, such that
movement of the translating member along the drive shaft relative to the latch base moves latch arm distal portion.

US Pat. No. 9,558,583

SYSTEMS AND METHODS FOR TRACKING POSITIONS BETWEEN IMAGING MODALITIES AND TRANSFORMING A DISPLAYED THREE-DIMENSIONAL IMAGE CORRESPONDING TO A POSITION AND ORIENTATION OF A PROBE

Hologic, Inc., Marlborou...

1. A method for calibrating a field of view of an imaging probe relative to a plurality of transmitters removably connected
to the imaging probe, the method comprising:
positioning an end of a configuration tool at a plurality of configuration positions on a transducer of the imaging probe,
the configuration tool having at least one transmitter;

recording a location of the configuration tool at each of the plurality of configuration positions; and
determining a calibration matrix based on the recorded location of the configuration tool at each of the plurality of configuration
positions, without using image information from the imaging probe, wherein the calibration matrix relates a transducer co-ordinate
frame to a transmitter coordinate frame, and wherein the transducer co-ordinate frame has an origin (O) at a center of a face
of the transducer, the origin determined from the recorded location of the configuration tool at each of the plurality of
configuration positions.

US Pat. No. 9,498,176

METHODS AND SYSTEMS FOR DYNAMICALLY MODIFYING ACQUISITION PARAMETER DURING IMAGE ACQUISITION

Hologic, Inc., Marlborou...

1. A computer-implemented method for acquiring a plurality of images of breast tissue during a scan of the breast tissue,
the method comprising:
acquiring a 2D projection image of breast tissue;
processing the 2D projection image to determine a physical characteristic of the breast tissue;
determining whether a plurality of 3D projection images of the breast tissue should be acquired based at least in part upon
the physical characteristic; and

acquiring a plurality of 3D projection images when it is determined that a plurality of 3D projection images of the breast
tissue should be acquired.

US Pat. No. 9,456,797

SYSTEM AND METHOD FOR GENERATING A 2D IMAGE FROM A TOMOSYNTHESIS DATA SET

HOLOGIC, INC., Bedford, ...

1. A method for imaging breast tissue, comprising:
obtaining an x-ray tomosynthesis data set of a patient's breast, the x-ray tomosynthesis data set comprising one or more of
tomosynthesis projection images and tomosynthesis reconstructed images;

synthesizing a two-dimensional mammogram from only the x-ray tomosynthesis data set; and
displaying the synthesized mammogram on a display device, wherein the synthesized mammogram comprises a synthesized 2D image
that simulates a conventional mammography image.

US Pat. No. 9,428,810

DETECTION OF A TARGET IN A PRESERVATIVE SOLUTION

Hologic, Inc., Marlborou...

1. A method for the detection of a target in a sample, wherein the target binds to one or more peptide nucleic acid (PNA)
probe(s), the method comprising: contacting said sample with one or more PNA probe(s) in an aqueous alcohol solution of at
least approximately 20% by volume solution under conditions in which the PNA probe(s) can bind to the target, if present;
and detecting the PNA probe(s) bound to the target, wherein the aqueous alcohol solution is at least approximately 40% by
volume.

US Pat. No. 9,339,288

UTERINE FIBROID TISSUE REMOVAL DEVICE

HOLOGIC, INC., Marlborou...

1. A uterine fibroid tissue removal device, comprising:
a housing;
an outer tube having a distal end and a proximal end, the proximal end of the outer tube supported by the housing, the outer
tube configured for transcervical insertion into a uterus and having a tissue resection window located proximate to the distal
end of the outer tube, the tissue resection window having a longitudinally oriented length,

an inner tube disposed within the outer tube and configured to be translated and rotated relative to the outer tube during
operation of the tissue removal device; and

a unitary distal tip member formed separately from the inner tube, wherein the inner tube is formed from a first material
and the distal tip member is formed from a second material harder than the first material, the distal tip member being attached
to a distal end of the inner tube such that an axial lumen of the distal tip member is in fluid communication with an axial
lumen of the inner tube, and such that the distal tip member translates and rotates relative to the outer tube along with
the inner tube during operation of the tissue removal device so that a distal facing open cutting end of the distal tip member
in fluid communication with the axial lumen of the distal tip member translates across the tissue resection window of the
outer tube to sever tissue extending therethrough,

wherein the axial lumen of the distal tip member is smaller in cross-sectional area than the axial lumen of the inner tube,
and wherein the distal tip member has a length greater than a length of the tissue resection window.

US Pat. No. 9,198,795

IMPLANT DELIVERY DEVICE

HOLOGIC, INC., Marlborou...

1. A method of implanting a compressible occlusive device in a fallopian tube of a patient, the fallopian tube having an ostium,
comprising:
inserting a distal section of an introducer into the fallopian tube until the distal section is adjacent an implant location
in the fallopian tube, and such that an intermediate section of the introducer is positioned outside of the fallopian tube
adjacent the ostium;

moving the occlusive device from the intermediate section of the introducer into the distal section, wherein the intermediate
section has an intermediate section inner diameter, such that the occlusive device, when disposed in the intermediate section,
is in a substantially uncompressed configuration, wherein, when the occlusive device is moved from the intermediate section
to the distal section, the occlusive device passes through a transition section of the introducer that compresses the occlusive
device; and

deploying the occlusive device out a distal opening in the distal section of the introducer and into the fallopian tube at
the implant location.

US Pat. No. 9,161,727

INDEPENDENTLY ROTATABLE DETECTOR PLATE FOR MEDICAL IMAGING DEVICE

Hologic Inc, Marlborough...

1. Apparatus comprising:
an imaging device including an emitter, a collimator, a detector, and a support assembly, the collimator and detector being
mounted on the support assembly and being rotationally movable independent of the support assembly, wherein rotation of the
collimator matches rotation of the detector and an axis of rotation of the collimator is the same axis of rotation of the
detector, and

a display for presenting an image to an operator, and image orientation logic which displays a target anatomy in a selected
orientation in response to user input so that the orientation is presented regardless of orientation of the target anatomy
relative to the detector, and regardless of rotation of the detector.

US Pat. No. 9,086,356

VISCERAL FAT MEASUREMENT

HOLOGIC, INC., Bedford, ...

1. A method comprising:
acquiring x-ray measurements using a dual-energy x-ray absorptiometry (DXA) system for respective pixel positions related
to a two-dimensional projection image of a portion of a subject's abdomen, wherein at least some of the measurements are dual-energy
x-ray measurements;

placing a plurality of regions of the image in which the image is obtained using the DXA system, wherein said placing includes
placing a first region of the image which extends from a first side of the abdomen to a second side of the abdomen, and placing
a second region which extends across an inner abdominal cavity from the first side to the second side between innermost extents
of an abdominal muscle wall, and wherein said placing of said second region of the image includes identifying a left and a
right innermost extent of abdominal muscle wall by identifying inflection of adipose tissue values;

computer processing to combine the plurality of regions to provide an estimate of visceral fat (VAT) in which said estimate
of visceral fat is distinguishable from subcutaneous fat (SAT), wherein said computer processing includes computer processing
at least some of the x-ray measurements for placing the second region of the image; and

providing and displaying selected results related to said estimate of visceral fat in which said selected results of visceral
fat is distinguishable from subcutaneous fat.

US Pat. No. 9,076,246

SYSTEM AND METHOD OF OVERLAYING IMAGES OF DIFFERENT MODALITIES

HOLOGIC, INC., Marlborou...

1. A method overlaying a three-dimensional image of a tissue and an image of the tissue from an imaging transducer, having
a field of view, the method comprising:
co-registering a first co-ordinate space of the three-dimensional image with a second co-ordinate space of the field of view
of the image from the imaging transducer;

determining pixel dimensions of the field of view in the second co-ordinate space;
scaling the three-dimensional image in the first co-ordinate space to match the pixel dimensions of the field of view in the
second co-ordinate space, wherein the pixel dimensions comprise pixel width and pixel height; and

transforming position and orientation of the three-dimensional image in the first co-ordinate space to match position and
orientation of the field of view in the second co-ordinate space; and

displaying an overlaid image comprising the three-dimensional image and the field of view of the imaging transducer,
wherein scaling the three-dimensional image reduces distortion of the overlaid three-dimensional image.

US Pat. No. 9,504,436

METHOD FOR BREAST SCREENING IN FUSED MAMMOGRAPHY

Hologic, Inc., Bedford, ...

1. A method comprising:
acquiring a medical image of a patient using a first imaging modality;
computer-processing the image to identify a sub-region of the image that contains a suspected abnormality;
acquiring a medical image of the sub-region using a different imaging modality; and
displaying results related to said image of the sub-region acquired with the different imaging modality;
wherein one of the modalities is x-ray imaging and the other is ultrasound imaging.

US Pat. No. 9,502,148

TOMOSYNTHESIS WITH SHIFTING FOCAL SPOT AND OSCILLATING COLLIMATOR BLADES

Hologic, Inc., Bedford, ...

1. A method comprising:
emitting x-ray radiation from an x-ray source during a tomosynthesis scan towards at least one collimator blade so as to collimate
the x-ray radiation, wherein the at least one collimator blade at least partially defines a static focal spot having a predetermined
size;

synchronously moving generally, during the emission of x-ray radiation, the x-ray source in a first direction and the at least
one collimator blade in a second direction, so as to maintain the predetermined size of the static focal spot; and

receiving the collimated x-ray radiation at a detector.

US Pat. No. 9,480,822

LOCKING DEVICE

Hologic, Inc., Bedford, ...

1. A slidable locking device, comprising:
a housing having a passageway therethrough;
an actuator coupled to the housing and movable between a locked position and an unlocked position, the actuator having at
least two arms extending therefrom; and

at least two engaging members disposed within the housing and operatively coupled to the actuator, each engaging member having
a slot configured to receive a respective arm of the actuator, and wherein the engaging members are biased towards the housing
passageway, and the engaging members are disposed toward the housing passageway when the actuator is in the locked position,
and the engaging members are disposed away from the housing passageway when the actuator is in the unlocked position,

the device further comprising a connector coupled between the housing and the actuator, wherein the connector defines a pivot
axis and the actuator is configured to move about the pivot axis between the locked position and the unlocked position.

US Pat. No. 9,066,706

INTEGRATED MULTI-MODE MAMMOGRAPHY/TOMOSYNTHESIS X-RAY SYSTEM AND METHOD

Hologic, Inc., Bedford, ...

1. A system for multi-mode breast x-ray imaging comprising:
a compression arm assembly for compressing and immobilizing a patient's breast for x-ray imaging, the compression arm assembly
comprising a breast compression paddle;

an x-ray tube assembly; and
an x-ray image receptor, wherein the compression arm assembly, the x-ray tube assembly, and the x-ray image receptor are configured
for movement to accommodate a plurality of imaging modes, wherein the x-ray tube assembly is configured to rotate relative
to the breast compression paddle about an axis for at least one of the plurality of imaging modes, and

wherein the breast compression paddle is configured to move laterally relative to the x-ray image receptor, and wherein at
least two or more of the plurality of imaging modes utilize the same breast compression.

US Pat. No. 9,595,100

METHOD AND SYSTEM FOR PROCESSING AN IMAGE OF A BIOLOGICAL SPECIMEN

HOLOGIC, INC., Marlborou...

1. A method of processing an image of a biological specimen using an image processor, the specimen image including a plurality
of cells, the method comprising:
identifying a component of one of the cells in the image; and
evaluating a characteristic of the component in order to determine whether the respective cell having the component has a
likelihood of being a cancerous cell or a repair cell,

wherein evaluating a characteristic of the component comprises:
comparing one or more characteristics of the component to one or more characteristics of a component of a cell known to be
cancerous;

comparing one or more characteristics of the component to one or more characteristics of a component of a cell known to be
a repair cell; and

determining, based on the respective comparisons, whether the respective cell having the component has a likelihood of being
a cancerous cell or a repair cell.

US Pat. No. 9,492,130

SYSTEM FOR IMPROVED TISSUE-HANDLING AND IN LINE ANALYSIS OF THE TISSUE

HOLOGIC, INC., Bedford, ...

1. A tissue biopsy and imaging system, comprising:
an imager comprising an imaging field;
a specimen holder; and
a biopsy device having a tissue output portion fluidly coupled to the specimen holder by a flexible tissue aspiration line,
wherein the specimen holder is positioned in a fluid communication path between the biopsy device and a vacuum source so such
that a tissue sample obtained with the biopsy device is delivered through the aspiration line into a tissue holding compartment
of the specimen holder,

wherein the system is configured to move the specimen holder relative to the imager in order to position the tissue holding
compartment within the imaging field of the imager for imaging the tissue sample while the specimen holder remains positioned
in the fluid communication path.

US Pat. No. 9,153,021

ESTIMATING RISK OF FUTURE BONE FRACTURE UTILIZING THREE-DIMENSIONAL BONE DENSITY MODEL

HOLOGIC, INC., Bedford, ...

1. A computer-implemented method for analyzing a patient's body part of interest to assess bone strength and/or risk of future
fracture, said method comprising:
obtaining a priori information regarding the body part of interest, said a priori information comprising a three-dimensional
(3D) generic model of a comparable body part;

performing X-ray absorptiometric scans of the patient's body part of interest and collecting X-ray absorptiometry data from
the X-ray absorptiometric scans, said data being derived using x-ray imaging detectors included in a computer-driven data
acquisition system, said data representing a plurality of two-dimensional (2D) images of the patient's body part, each of
said 2D images of the patient's body part being at a respective orientation of an imaging x-ray beam relative to the patient's
body part;

constructing a three-dimensional model of the patient's body part of interest, by utilizing the a priori information along
with the X-ray absorptiometric data, said constructing comprising operating computerized equipment to carry out the steps
of:

(i) obtaining one or more two-dimensional (2D) projection views of the 3D generic model that correspond in orientation to
one or more of the 2D images of the patient's body part,

(ii)comparing each of the one or more 2D projection views of the generic model with a corresponding 2D image of the patient's
body part to calculate a cost function,

(iii) modifying the 3D model according to said cost function, and
(iv) repeating steps (i) through (iii), each time using in step (i) the 3D model as modified in the previous iteration of
step (iii), until a selected threshold has been reached;

performing finite element analysis on the three-dimensional model of the patient's body part as modified through said constructing
to provide parameters relating to bone strength of the patient's body part; and

estimating force of a hypothetical fall by the patient;
wherein said parameters relating to bone strength are considered in combination with one or more other parameters to estimate
said force of the fall.

US Pat. No. 9,119,593

MULTI-MODE TOMOSYNTHESIS/MAMMOGRAPHY GAIN CALIBRATION AND IMAGE CORRECTION USING GAIN MAP INFORMATION FROM SELECTED PROJECTION ANGLES

HOLOGIC, INC., Bedford, ...

1. A method of operating an x-ray breast tomosynthesis system comprising:
acquiring a multiplicity of x-ray tomosynthesis projection images of a patient's breast at respective projection angles of
an imaging x-ray beam relative to the breast;

computer-processing the multiplicity of x-ray tomosynthesis projection images into a plurality of tomosynthesis slice images
of the patient's breast, each tomosynthesis slice image representing a three-dimensional slab of breast tissue extending along
a plane that is at respective angle relative to the breast;

generating, by a computer-implemented map generator, correction information that relates differences between image information
from measured values and image information from expected values for at least one of the multiplicity of x-ray tomosynthesis
projection images and the plurality of tomosynthesis slice images;

said correction information having been derived from multiple x-ray projection images of a phantom taken at respective different
angles of an imaging x-ray beam to the phantom where said expected values relate to known information about the phantom;

applying, by a computer process, said correction information to at least one of the multiplicity of x-ray tomosynthesis projection
images and the plurality of tomosynthesis slice images to obtain display images of the patient's breast; and

displaying the display images of the patient's breast on a display device.

US Pat. No. 9,865,050

MEASURING INTRAMUSCULAR FAT

HOLOGIC, INC., Marlborou...

1. A dual energy x-ray absorptiometry (DEXA) method for determining intramuscular fat of a selected sub-volume of an intramuscular
fat volume of a patient, which intramuscular fat volume is surrounded by a subcutaneous fat volume and together therewith
forms a total volume of a patient's limb, comprising:
acquiring x-ray measurements of the patient's limb for respective pixel positions related to a two-dimensional projection
image of said total volume, wherein at least some of the measurements are dual-energy x-ray measurements of the subcutaneous
fat and the intramuscular fat to thereby make subcutaneous fat and intramuscular fat regions of the patient visible in a dual-energy
image of the patient's limb;

placing a plurality of regions relative to the image;
computer processing said dual-energy x-ray measurements to determine a metric of intramuscular fat contained in said sub-volume
of the intramuscular fat volume that also contains material that is not intramuscular fat; and

providing and displaying selected results related to said intramuscular fat metric.

US Pat. No. 9,808,214

UPRIGHT X-RAY BREAST IMAGING WITH A CT MODE, MULTIPLE TOMOSYNTHESIS MODES, AND A MAMMOGRAPHY MODE

HOLOGIC, INC., Bedford, ...

1. A system for imaging a breast of an upright patient with x-rays comprising:
a breast compression unit configured to compress a breast of an upright patient to different degrees at different angles relative
to the breast;

an x-ray data acquisition unit configured to operate the system in a computerized tomography (CT) mode to thereby generate
a plurality of CT x-ray projection images CTp of the breast taken at different angles; and

an image processing unit configured to computer-process the images CTp to thereby generate a three-dimensional reconstructed
image CTr of at least a portion of the breast.

US Pat. No. 9,811,758

MATCHING GEOMETRY GENERATION AND DISPLAY OF MAMMOGRAMS AND TOMOSYNTHESIS

HOLOGIC, INC., Marlborou...

1. A method comprising:
imaging a breast so as to acquire digital information corresponding to a plurality of 2D x-ray tomosynthesis projection images
of the breast taken at different angles;

generating, from the digital information, a plurality of reconstructed tomosynthesis images representative of respective breast
layers;

obtaining a 2D mammogram image of the breast; and
displaying at least one of the plurality of reconstructed tomosynthesis images representative of respective breast layers
and the 2D mammogram image of the breast.

US Pat. No. 9,095,306

IMAGE HANDLING AND DISPLAY IN X-RAY MAMMOGRAPHY AND TOMOSYNTHESIS

HOLOGIC, INC., Bedford, ...

1. A method of displaying x-ray image data comprising:
acquiring two-dimensional x-ray projection images of a three-dimensional object obtained by using a tomosynthesis x-ray data
acquisition unit that acquires each of the two-dimensional images by projecting an x-ray beam through the object at respective
different angles of the beam relative to the object rather than by reconstructing a slice image;

reconstructing at least a portion of the acquired two-dimensional projection images into three-dimensional image data representing
the three-dimensional object;

concurrently displaying on a display device (a) at least one of said two-dimensional projection x-ray images rather than images
produced by reconstructing a slice image and (b) at least a portion of the three-dimensional reconstructed image data.

US Pat. No. 9,498,180

DETECTING AND QUANTIFYING PATIENT MOTION DURING TOMOSYNTHESIS SCANS

HOLOGIC, INC., Bedford, ...

1. Apparatus comprising:
an image acquisition mechanism that generates a plurality of images of an imaging target of an individual in a time series
during a scan;

an image processor that processes the plurality of images to generate processed images, wherein the processed images are at
least one of projection images and reconstructed images;

a computer which is configured to display the processed images and which detects and quantifies motion of the target of a
magnitude of between about 70 ?m to about 420 ?m during the scan by comparing an actual location of at least one point of
reference in each processed image with an expected location of the at least one point of reference derived from a set of the
processed images and by generating a motion score, wherein the at least one point of reference is an intrinsic marker of the
individual and wherein the intrinsic marker comprises a plurality of points along a skin line; and

a mechanism for comparing the motion score to a threshold and for prompting a responsive action if the motion score exceeds
the threshold.

US Pat. No. 9,330,232

DISPLAYING AND NAVIGATING COMPUTER-AIDED DETECTION RESULTS ON A REVIEW WORKSTATION

Hologic, Inc., Marlborou...

1. A computer-implemented method for displaying a plurality of computer-aided detection (CAD) detections associated with a
tomosynthesis case, the tomosynthesis case comprising a plurality of images, the tomosynthesis case being processed by a CAD
algorithm that identifies CAD detections therein based at least in part upon respective computed features associated with
respective CAD detections: displaying the plurality of tomosynthesis images to a viewer, respective tomosynthesis images comprising
respective CAD markers corresponding to respective locations of respective CAD detections in respective tomosynthesis images;
mapping a computed feature onto an operating curve of a navigational tool, the navigational tool comprising a plot of the
operating curve and a plurality of CAD pointer icons, respective CAD pointer icons corresponding to respective CAD detections,
the plurality of CAD pointer icons being spatially distributed along the navigational tool according to the mapping, each
CAD pointer icon representing a CAD detection and visually communicating an aspect of the CAD detection to the viewer by the
position of the graphical symbol on the plot; and displaying the navigational tool in proximity to at least one tomosynthesis
image to the viewer.

US Pat. No. 9,202,275

BREAST TOMOSYNTHESIS WITH DISPLAY OF HIGHLIGHTED SUSPECTED CALCIFICATIONS

HOLOGIC, INC., Bedford, ...

1. A method of acquiring and displaying breast tissue images, comprising:
acquiring x-ray image data of a patient's breast, the x-ray image data comprising projection images taken at different angles
of an origin of imaging x-rays relative to the patient's breast;

generating tomosynthesis image data from the acquired x-ray image data, the tomosynthesis image data comprising a plurality
of image slices of the patient's breast, each image slice having an orientation and a thickness;

identifying an image slice of interest in the tomosynthesis image data, the identified image slice of interest depicting an
object of interest; and

displaying an image stack guide on a user interface, the image stack guide comprising
a linear display object having a plurality of marks, each mark of the plurality associated with a respective image slice of
the plurality of image slices, such that a user can navigate through the plurality of image slices using the linear display
object, and

an indicator disposed adjacent a respective mark on the linear display object associated with the identified image slice of
interest.

US Pat. No. 9,693,890

VARIABLE STIFFNESS FLEXURE

Hologic, Inc., Marlborou...

1. An intrauterine device, comprising:
a central support member;
first and second inner flexures, each having a proximal portion, a middle portion, and distal portion, and wherein the proximal
portion of each inner flexure is coupled to the central support member;

an arm member, having a proximal portion and a distal portion, wherein the proximal portion of the arm member is coupled to
the middle portion of the first inner flexure at a first location, and wherein the first inner flexure and the arm member
extend distally from the first location and form an acute angle with each other; and

first and second outer flexures, each having a proximal end and a distal end, wherein the respective proximal ends of the
first and second outer flexures are coupled to the central support member, and wherein the respective distal ends of the first
and second outer flexures are coupled to the respective distal portions of the respective first and second inner flexures,

wherein the first and second outer flexures, in combination with the arm member and in further combination with the first
and second inner flexures comprise a delivery configuration for transcervical insertion, and a deployed configuration for
deployment in a uterine cavity.

US Pat. No. 9,668,988

CONTROLLED RELEASE ORAL PHARMACEUTICAL DOSAGE FORMS COMPRISING MGBG

Pathologica LLC, San Fra...

1. A method of treating multiple sclerosis comprising the administration, to a patient in need thereof, of an enterically-coated,
delayed-release oral pharmaceutical dosage form comprising methylglyoxal bis(guanylhydrazone) (MGBG).

US Pat. No. 9,498,175

SYSTEM AND METHOD FOR LOW DOSE TOMOSYNTHESIS

Hologic, Inc., Bedford, ...

1. A method of imaging a breast using a multi-mode mammography/tomosynthesis system, the method comprising:
acquiring a two-dimensional image of a breast using a first x-ray dose in a first mode of operation of the multi-mode mammography/tomosynthesis
system, wherein the first x-ray dose is emitted from an emission source when the emission source is stationary; and

acquiring a set of tomosynthesis images of the breast in a second mode of operation of the multi-mode mammography/tomosynthesis
system, wherein the set of tomosynthesis images is acquired from a plurality of projection images, wherein each of the plurality
of projection images is acquired at a projection image x-ray dose less than the first x-ray dose, wherein each projection
image x-ray dose is emitted when the emission source is rotating relative to the breast.

US Pat. No. 9,460,508

IMAGE HANDLING AND DISPLAY IN X-RAY MAMMOGRAPHY AND TOMOSYNTHESIS

HOLOGIC, INC., Bedford, ...

1. An image display system comprising:
a display for displaying:
at least one image of a plurality of tomosynthesis images of a compressed breast; and
a slider bar for identifying information regarding a location within the compressed breast corresponding to the displayed
image, wherein the slider bar comprises a slice bar configured to be moved along the slider bar and wherein

when the slice bar is positioned in a first position along the slider bar, the display displays a first image of the plurality
of tomosynthesis images, wherein the first image has a first height within the breast; and

when the slice bar is positioned in a second position adjacent to the first position along the slider bar, the display displays
a second image of the plurality of tomosynthesis images, wherein the second image has a second height adjacent to the first
height within the breast.

US Pat. No. 9,392,935

METHODS FOR PERFORMING A MEDICAL PROCEDURE

HOLOGIC, Inc., Marlborou...

1. A method of performing a medical procedure, said method comprising the steps of:
a) using a mechanical expansion structure to maintain a uterus in a distended state equivalent to that achieved by introduction
of a liquid distension media at a pressure of at least 40 mm Hg; and

b) performing at least one of examining and treating tissue located within the distended uterus.

US Pat. No. 9,384,325

SYSTEM AND METHOD FOR GENERATING ENHANCED DENSITY DISTRIBUTION IN A THREE DIMENSIONAL MODEL OF A STRUCTURE FOR USE IN SKELETAL ASSESSMENT USING A LIMITED NUMBER OF TWO DIMENSIONAL VIEWS

Hologic Inc, Marlborough...

1. A computer implemented method of generating a density enhanced customized model of an object comprising:
generating a customized model of an object using a generic model of the object, the customized model comprising at least one
volume element, the at least one volume element including density information;

generating a density map using a synthesized projection image of the customized model and a projection image of the object;
modifying the density information of the at least one volume element with information from the density map into the customized
model to provide a density enhanced customized model of the object; and

performing at least one of storing the density enhanced customized model of the object and displaying the density enhanced
customized model of the object on a user display.

US Pat. No. 9,226,721

TOMOSYNTHESIS WITH SHIFTING FOCAL SPOT AND OSCILLATING COLLIMATOR BLADES

HOLOGIC, INC., Bedford, ...

1. A system comprising:
an x-ray source configured to move in a first direction during a tomosynthesis scan;
a detector configured to obtain images during the tomosynthesis scan;
at least one collimator blade, wherein the at least one collimator blade is configured to move in a second direction different
from the first direction during the tomosynthesis scan, and wherein the at least one collimator blade is configured to control
dispersion of radiation from the x-ray source; and

a motion controller for generally synchronizing an at least one collimator blade movement with an x-ray source movement, wherein
the motion controller is configured to move the at least one collimator blade at a collimator blade linear speed equal to
an x-ray source linear speed during an exposure.

US Pat. No. 9,180,312

BRACHYTHERAPY DEVICE FOR ASYMMETRICAL IRRADIATION OF A BODY CAVITY

HOLOGIC, INC., Bedford, ...

1. A brachytherapy device for treating tissue surrounding a body cavity of a patient, comprising:
a) a shaft having a proximal end, a distal end, a distal treatment portion proximal the distal end, and a longitudinal axis,
the shaft having a plurality of off-set radiation delivery lumens radially off-set from the longitudinal axis that extend
into the distal treatment portion, each of the plurality of off-set radiation delivery lumens being configured to receive
a radiation source, wherein the plurality of off-set radiation delivery lumens are deformable into an arcuate shape;

b) an expandable member coupled to the shaft to define an expandable volume that surrounds the distal treatment portion, the
expandable member being configured to increase space between the expandable member and the plurality of off-set radiation
delivery lumens as the expandable member is expanded.

US Pat. No. 9,332,947

X-RAY MAMMOGRAPHY AND/OR BREAST TOMOSYNTHESIS USING A COMPRESSION PADDLE WITH AN INFLATABLE JACKET WITH DUAL BOTTOM LAYER JOINED AT A SEAM ENHANCING IMAGING AND IMPROVING PATIENT COMFORT

HOLOGIC, INC., Bedford, ...

1. An x-ray breast imaging system comprising:
a data acquisition unit comprising an x-ray source configured to selectively emit an imaging x-ray beam, an image receptor
configured to receive said beam and produce a plurality of x-ray imaging information in response thereto, and a breast immobilizer
between the source and the receptor;

said breast immobilizer comprising a breast platform configured to support a patient's breast for imaging with said beam and
a compression paddle supported for movement toward the breast platform to compress the breast and away from the breast platform
to release the breast;

said compression paddle having a front wall configured to be adjacent the patient's chest wall when the patient's breast is
supported for said imaging, side walls extending transversely to the front wall, and an underside facing the breast platform;

a paddle jacket removably secured to the compression paddle, said jacket having a first flexible sheet and a second flexible
sheet joined at a seam, wherein the first flexible sheet and the second flexible sheet extend along the underside of the paddle
when secured to the paddle and form an inflatable chamber, and a fluid conduit that is in fluid flow communication with said
chamber;

a fluid control unit releasably coupled with said conduit, said fluid control unit configured to selectively supply fluid
to said chamber through said conduit and thereby selectively inflate and deflate the chamber, said fluid control unit further
configured to maintain a substantially uniform internal pressure throughout an imaging procedure;

an image processor coupled with said image receptor and configured to receive said imaging information therefrom and produce
x-ray images; and

a workstation and system control unit coupled with said data acquisition unit, said fluid control unit and said image processor,
and configured to control operations thereof in response to operator inputs.

US Pat. No. 9,585,639

BIOPSY DEVICE ARMING MECHANISM

Hologic, Inc., Marlborou...

1. A biopsy device for percutaneous tissue removal, comprising:
an elongated housing having an operational axis;
a stylet hub slidably mounted in the housing, wherein the stylet hub is movable relative to the housing between a proximal,
armed position, and a distal, fired position, the stylet hub having a stylet strike;

a cannula hub slidably mounted in the housing alongside the stylet hub, wherein the cannula hub is movable relative to the
housing between a proximal, armed position, and a distal, fired position; and

a spring-biased arming member moveably mounted to the housing proximal of the respective stylet and cannula hubs, the arming
member configured for manually-actuated movement from a relaxed, extended position to a loaded, compressed position to define
a compressive arming stroke, wherein an arming member biasing spring restores the arming member from the compressed position
to the extended position,

the housing having a distal portion and a proximal portion, wherein the respective stylet and cannula hubs are disposed within
the distal portion of the housing, and the arming member is mounted to the proximal portion of the housing, the arming member
having a surface configured to be depressed relative to the proximal portion of the housing to thereby move the arming member
from the extended position into an interior of the proximal portion of the housing for completing the compressive arming stroke,
wherein the arming member surface is depressed away from the distal portion of the housing for completing the compressive
arming stroke.

US Pat. No. 9,146,663

DISPLAYING COMPUTER-AIDED DETECTION INFORMATION WITH ASSOCIATED BREAST TOMOSYNTHESIS IMAGE INFORMATION

Hologic, Inc., Marlborou...

1. A computer-implemented method for processing and displaying information associated with breast x-ray images acquired with
an imaging device, the method comprising:
receiving a plurality of two-dimensional breast x-ray tomosynthesis reconstructed image slices corresponding to a respective
plurality of slice depths in a compressed breast volume;

receiving a plurality of computer-aided detection (CAD) findings associated with the breast volume, each CAD finding identifying
a subset of the image slices spanned by a suspected anatomical abnormality and locations therein of the suspected anatomical
abnormality;

displaying on a user display a two dimensional image comprising a single one of the received image slices or a plurality of
depthwise adjacent ones of the received image slices slabbed together;

displaying a navigation tool on the user display in visual proximity to the two dimensional image, the navigation tool comprising:
an outline in miniaturized form of the breast volume, the outline having a depth dimension corresponding to a direction of
compression and a lateral dimension normal to the depth dimension,

a plurality of CAD indicator icons displayed within the outline, the plurality of CAD indicator icons corresponding to respective
CAD findings and being positioned at respective locations representative of respective associated CAD findings in the breast
volume, and

a slice slider bar extending across at least a portion of the outline, a first portion of the slice slider bar being controllable
by the user in the depth dimension to select the image depth, a second portion of the slice slider having an adjustable thickness
corresponding to the image thickness of the currently displayed image.

US Pat. No. 9,851,888

IMAGE HANDLING AND DISPLAY IN X-RAY MAMMOGRAPHY AND TOMOSYNTHESIS

HOLOGIC, INC., Marlborou...

1. A method of displaying tomosynthesis images, the method comprising:
obtaining a first set of tomosynthesis images, wherein the first set of tomosynthesis images includes a first number of images;
obtaining a second set of tomosynthesis images, wherein the second set of tomosynthesis images includes a second number of
images different than the first number of images; and

modifying the first set of tomosynthesis images so as to produce a modified first set of tomosynthesis images having a first
number of images equal to the second number of images.

US Pat. No. 9,901,315

X-RAY SCATTER REDUCING DEVICE FOR USE WITH 2D MAMMOGRAPHY AND TOMOSYNTHESIS

Hologic, Inc., Marlborou...

1. An apparatus for reducing X-ray scatter, the apparatus comprising:
a motor; and
an anti-scatter grid coupled to the motor, the anti-scatter grid having a plurality of septa, and the anti-scatter grid being
configured to be positioned relative to an X-ray imaging device such that each septum of the plurality of septa extends along
a direction substantially parallel to a coronal plane of a subject during imaging of the subject using the X-ray imaging device,

wherein the motor is configured to retract the anti-scatter grid out of the field of view in a first mode of the X-ray imaging
device and the motor is configured to move the anti-scatter grid relative to a detector in the field of view in a second mode
of the X-ray imaging device,

wherein the detector is configured to rotate during imaging in the second mode, and wherein the anti-scatter grid is configured
to move in a corresponding rotational direction with the detector during imaging in the second mode.

US Pat. No. 9,810,610

METHOD OF PARTIAL LYSIS AND ASSAY

Hologic, Inc., Marlborou...

1. A method of evaluating a biological sample comprising cells, said method comprising:
obtaining a biological sample from a subject;
contacting the biological sample with a biological sample preservative to create a preserved biological sample;
partially lysing the preserved biological sample to create a mixture comprising lysed cells, whole cells, and molecular components;
characterizing a first portion of the mixture using cell based analysis, wherein cell based analysis comprises mounting whole
cells on a slide; and

assaying a second portion of the mixture for molecular components.

US Pat. No. 9,693,758

TISSUE REMOVAL SYSTEM

Hologic, Inc., Marlborou...

1. A method for resecting tissue from a uterus using an elongate surgical device, the surgical device comprising a housing,
a vacuum chamber located in the housing, a manually-operated actuator mechanically coupled to a piston disposed in the vacuum
chamber, an outer tube having a sidewall opening near a distal end of the outer tube, and an inner tube including a cutting
edge configured to cut tissue, the inner tube being positioned within a lumen of the outer tube, the inner tube having a lumen
in fluid communication with the sidewall opening in the outer tube via a distal opening in the inner tube, the method comprising:
transcervically introducing a distal portion of the surgical device into the uterus so that the sidewall opening in the outer
tube is positioned adjacent to uterine wall tissue targeted for removal;

applying a force to the manually-operated actuator to move the piston and thereby generate vacuum in the vacuum chamber; and
after generating vacuum in the vacuum chamber, initiating translation of the inner tube relative to the outer tube to thereby
fluidly couple the respective inner tube lumen and tissue sidewall opening in the outer tube with the vacuum chamber, and
cause the targeted uterine wall tissue to prolapse into the sidewall opening.

US Pat. No. 9,649,068

TABLE FOR PERFORMING MEDICAL PROCEDURES

HOLOGIC, INC., Marlborou...

1. Apparatus comprising:
a table top including a rigid platform with an opening;
a plurality of interchangeable inserts, each of said plurality of interchangeable inserts being alternatively positionable
in the opening of the table top, each insert including a rigid member and a port through which a portion of a patient's body
extends during a medical procedure, wherein a first one of the interchangeable inserts is characterized by a different size
port than a second one of the interchangeable inserts;

a removable pad removably mounted over the interchangeable insert in the opening, the removable pad, when removably mounted
over the interchangeable insert in the opening, permitting the portion of the patient's body to extend through the port of
the interchangeable insert; and

a base including an upright pillar member connected to the table top, the pillar member being positioned to one side of the
table top such that the table top is cantilevered and an area beneath the table top is accessible for positioning equipment
for performing the medical procedure.

US Pat. No. 9,867,794

REGULATION OF OSTEOPONTIN

Pathologica LLC, San Fra...

1. A method of treating, or alleviating the symptoms of, multiple sclerosis (MS) comprising administering to a subject in
need of such treatment an effective amount of MGBG or a salt thereof.

US Pat. No. 9,649,075

X-RAY MAMMOGRAPHY AND/OR BREAST TOMOSYNTHESIS USING A COMPRESSION PADDLE WITH AN INFLATABLE JACKET ENHANCING IMAGING AND IMPROVING PATIENT COMFORT

Hologic, Inc., Marlborou...

1. An x-ray breast imaging system comprising:
a breast immobilizer comprising a breast platform configured to support a patient's breast for imaging and a compression paddle
supported for movement toward the breast platform to compress the breast and away from the breast platform to release the
breast;

said compression paddle having a front wall configured to be adjacent the patient's chest wall when the patient's breast is
supported for said imaging, side walls extending transversely to the front wall, and an underside facing the breast platform;

a paddle jacket removably secured to the compression paddle, said jacket having a top wall extending along the underside of
the paddle when secured to the paddle, and a bottom wall disposed opposite the top wall from the underside of the paddle,
wherein the top wall and the bottom wall define an inflatable chamber therebetween, and a fluid conduit that is in fluid flow
communication with said chamber, wherein the top wall and the bottom wall are fused to each other so as to form:

side walls that extend along the side walls of the compression paddle, and
a front wall that extends along the front wall of the compression paddle; and
a fluid control unit releasably coupled with said conduit to selectively supply fluid to said chamber through said conduit
and thereby selectively inflate the chamber.

US Pat. No. 9,901,309

BREAST BIOPSY AND NEEDLE LOCALIZATION USING TOMOSYNTHESIS SYSTEMS

Hologic Inc., Marlboroug...

1. A method for needle localization for breast biopsy, said method comprising:
(a) performing a tomosynthesis scan of a patient's compressed breast using a source of an imaging xray beam that moves through
a multiplicity of imaging positions along a source trajectory, and obtaining image data from the tomosynthesis scan and deriving
therefrom (i) tomosynthesis projection images of the compressed breast taken from more than two of the imaging positions of
the source relative to the compressed breast and (ii) tomosynthesis reconstructed slice images representing respective slices
of the compressed breast;

(b) displaying at least one of the tomosynthesis images of the patient's compressed breast, wherein the displayed at least
one of the tomosynthesis images has a known location within a depth of the compressed breast;

(c) indicating on a user interface of the display on the at least one of the tomosynthesis images an area of interest of the
patient's compressed breast;

(d) determining therefrom three-dimensional coordinates of the area of interest;
(e) positioning a biopsy needle based on the three-dimensional coordinates of the area of interest, such that a portion of
the biopsy needle extends into a field defined by the xray beam without penetrating the area of interest and the biopsy needle
is positioned so as to not form an image artifact on the area of interest in relation to the xray beam;

(f) after positioning the biopsy needle, imaging the patient's compressed breast and the biopsy needle so as to obtain an
image; and

(g) after imaging the patient's breast and the biopsy needle, determining three-dimensional coordinates of the biopsy needle
relative to the area of interest.

US Pat. No. 9,895,192

INTRAUTERINE TREATMENT DEVICE WITH ARTICULATING ARRAY

Hologic, Inc., Marlborou...

9. An intrauterine ablation device, comprising:
a sheath configured for transcervical introduction;
an articulating array slidably disposed within the sheath and comprising at least three serially disposed expansion chambers,
the articulating array having an insertion geometry in which the expansion chambers are in a linear deflated configuration
that may be inserted into a uterus through the sheath, and an installed geometry, in which the expansion chambers are inflated
and assume a furled frond-like configuration;

a conductive array disposed on a surface of the articulating array, wherein the conductive array is configured to contact
uterine wall tissue when the conductive array is inserted into the uterus and transitioned to the installed geometry; and

a controller configured to control pressure within the plurality of expansion chambers so as to transition the articulating
array between the installed geometry and the insertion geometry, wherein inflation of the plurality of expansion chambers
causes the articulating array to transition from the linear insertion geometry to the furled frond-like installed geometry.

US Pat. No. 9,687,331

LOCKING DEVICE

Hologic, Inc., Marlborou...

1. A slidable locking device, comprising:
a housing having a passageway therethrough;
an actuator coupled to the housing and movable between a locked position and an unlocked position, the actuator having at
least two arms extending therefrom; and

at least two engaging members disposed within the housing wherein the at least two engaging members are moveable relative
to the housing and operatively coupled to the actuator, each engaging member having a slot configured to receive a respective
arm of the actuator, and wherein the engaging members are biased towards the housing passageway, and the engaging members
are disposed toward the housing passageway when the actuator is in the locked position, and the engaging members are disposed
away from the housing passageway when the actuator is in the unlocked position.

US Pat. No. 9,554,853

RADIO-FREQUENCY GENERATOR FOR POWERING AN ABLATION DEVICE

Hologic, Inc., Marlborou...

1. A system for ablating uterine tissue comprising:
a radio frequency (RF) ablation device comprising an elongate member and expandable applicator head coupled to a distal portion
of the elongate member, the applicator head comprising a tissue contacting surface and an expandable-contractible carrying
member, the carrying member having a contracted state and an expanded state, the contracted state being configured for transcervical
insertion and the expanded state being configured for positioning the applicator head in contact with tissue to be ablated,
the applicator head including one or more electrodes for ablating endometrial lining tissue of the uterus, the RF ablation
device being configured to determine data related to the uterine cavity based on a degree of expansion of the carrying member
when in the expanded configuration; and

an RF generator, wherein when the RF generator is operably coupled to the RF ablation device, the RF generator is configured
to receive the data from the RF ablation device and to provide an RF signal to the RF ablation device based on the data.

US Pat. No. 9,549,711

PATIENT SUPPORT PADS FOR USE IN DETECTING LYMPHEDEMA THROUGH X-RAY SCANS

HOLOGIC, INC., Bedford, ...

9. A method of analyzing a body composition of a patient comprising:
providing a dual energy x-ray absorptiometry system, the system comprising a computer, an x-ray source and a patient support
platform;

positioning the patient in a supine position on the patient support platform;
positioning a spacer pad between body parts of the patient such that the spacer pad is positioned within a field of view of
the dual energy x-ray absorptiometry system;

scanning the patient with the dual energy x-ray absorptiometry system to measure the body composition; and
computer processing image information acquired from the scanning step and detecting the spacer pad to provide an analysis
of the body composition, such that the analysis of the body composition does not include information about the spacer pad.

US Pat. No. 9,060,760

TISSUE REMOVAL SYSTEM

HOLOGIC, INC., Marlborou...

1. A tissue removal device, comprising:
a housing;
an outer tubular member coupled to the housing and having a distal portion including a tissue resection window;
an inner tubular member slidably disposed within the outer tubular member and defining an inner lumen extending from an open
distal end to an open proximal end, the open distal end comprising a cutting edge to sever tissue extending through the tissue
resection window;

a vacuum generation chamber disposed in the housing including a movable piston disposed in the vacuum generation chamber;
a tissue trap disposed in or coupled to the housing, the tissue trap defining a sealed interior in fluid communication with
the vacuum generation chamber via a one-way valve, so that air may be withdrawn from the tissue trap interior into the vacuum
generation chamber by movement of the piston in a first direction, while air is prevented from entering the tissue trap interior
from the vacuum generation chamber due to movement of the piston in a second direction opposite the first direction, wherein
the open proximal end of the inner tubular member is disposed within the tissue trap interior; and

a manual actuator moveably coupled to the housing and operatively connected to the piston, such that movement of the actuator
relative to the housing causes movement of the piston within the vacuum generation chamber wherein the actuator is selectively
operatively coupled to the inner tubular member such that movement of the actuator relative to the housing causes movement
of the inner tubular member relative to the outer tubular member, wherein in a first configuration the actuator is not operatively
coupled to the inner tubular member, and in a second configuration the actuator mechanically engages the inner tubular member
such that movement of the actuator relative to the housing causes the open distal end of the inner tubular member to move
distally across the tissue resection window as the actuator is moved relative to the housing.

US Pat. No. 10,248,882

MATCHING GEOMETRY GENERATION AND DISPLAY OF MAMMOGRAMS AND TOMOSYNTHESIS IMAGES

Hologic, Inc., Marlborou...

1. A method comprising:imaging a breast so as to acquire digital information corresponding to a plurality of x-ray tomosynthesis projection images of the breast taken at different angles;
generating, from the digital information, a plurality of reconstructed tomosynthesis images representative of respective breast layers;
obtaining a mammogram image of the breast;
receiving a selection of a region of interest in the mammogram image of the breast; and
displaying a portion of at least one of the plurality of reconstructed tomosynthesis images corresponding to the selected region of interest.

US Pat. No. 9,707,124

METHODS AND APPARATUS FOR OCCLUSION OF BODY LUMENS

Hologic, Inc., Marlborou...

1. A method of using an elongate implantable device to create a permanent occlusion at a desired occlusion site in a fallopian
tube, the method comprising:
inserting a distal portion of the elongate implantable device into the fallopian tube using a delivery system, such that a
first tissue engaging element of the elongate implantable device carried on the distal portion is located distal of the desired
occlusion site and a second tissue engaging element of the elongate implantable device is located outside of, and adjacent
to an ostial opening of, the fallopian tube;

actuating the elongate implantable device so as to rotate one of the first and second tissue engaging elements relative to
the other of the first and second tissue engaging elements to thereby reduce an open area of the fallopian tube located between
the first and second tissue engaging elements; and

decoupling the elongate implantable device from the delivery system.

US Pat. No. 10,022,110

BIOPSY DEVICE

Hologic, Inc., Marlborou...

1. A biopsy system driver, comprising:a motor having a rotatable output shaft;
a support structure;
a drive shaft rotatably coupled to the support structure, the drive shaft comprising or otherwise being operatively connected to the motor output shaft such that activation of the motor rotates the drive shaft;
an elongate lead screw coupled to the drive shaft such that rotation of the drive shaft rotates the lead screw about an axis of the lead screw, the lead screw being axially translatable relative to the drive shaft and to the support structure;
a biopsy instrument drive member threadably coupled to the lead screw such that rotation of the lead screw causes axial translation of one of the lead screw and biopsy instrument drive member relative to the other one and to the support structure; and
a dwell spring assembly coupled to the lead screw,
the dwell spring assembly including a cylindrical dwell spring holder having a dwell spring seated therein, wherein a reduced diameter distal extension portion of the lead screw extends through an opening in a proximal end wall of the dwell spring holder, and through a lumen of the dwell spring, respectively, and is connected to a thrust bearing plate adjacent a distal end of the dwell spring,
the dwell spring being sized and configured such that, when the dwell spring holder is fixed to the support structure, the dwell spring resists compression between the thrust bearing plate and proximal end wall of the dwell spring holder sufficient to thereby maintain the lead screw in a fixed position relative to the respective dwell spring holder and support structure during activation of the motor, so that the biopsy instrument drive member moves freely relative to the lead screw.

US Pat. No. 10,010,302

SYSTEM AND METHOD FOR GENERATING A 2D IMAGE FROM A TOMOSYNTHESIS DATA SET

HOLOGIC, INC., Marlborou...

1. A system for evaluating breast tissue, comprising:a processor configured to
process a plurality of tomosynthesis projection images of a patient's breast tissue to generate a plurality of tomosynthesis reconstructed images;
generate a tomosynthesis data set comprising one or more of the plurality of tomosynthesis projection images and/or one or more of the plurality of tomosynthesis reconstructed images;
analyze the tomosynthesis data set using computer aided detection (CAD); and
generate a two-dimensional synthesized mammogram from the tomosynthesis data set, wherein the synthesized mammogram comprises a synthesized two-dimensional image that simulates a conventional mammography image.

US Pat. No. 9,895,115

TOMOSYNTHESIS WITH SHIFTING FOCAL SPOT AND OSCILLATING COLLIMATOR BLADES

Hologic, Inc., Marlborou...

1. A method comprising:
emitting x-ray radiation from an x-ray source during a tomosynthesis scan towards at least one collimator blade so as to collimate
the x-ray radiation, wherein the at least one collimator blade at least partially defines a static focal spot;

synchronously moving generally, during the emission of x-ray radiation, the x-ray source in a first direction and the at least
one collimator blade in a second direction, wherein movement of the at least one collimator blade controls dispersion of the
x-ray radiation so as to maintain the static focal spot; and

receiving the collimated x-ray radiation at a detector.

US Pat. No. 9,539,019

UTERINE FIBROID TISSUE REMOVAL DEVICE

Hologic, Inc., Bedford, ...

1. A uterine fibroid tissue removal device, comprising:
a housing;
an outer tube having a distal end and a proximal end, the proximal end of the outer tube supported by the housing, the outer
tube configured for transcervical insertion into a uterus and having a tissue resection window located proximate to the distal
end of the outer tube, the tissue resection window having a longitudinally oriented length;

an inner tube disposed within the outer tube and configured to be translated and rotated relative to the outer tube during
operation of the tissue removal device, the inner tube having an axial lumen; and

a unitary distal tip member formed separately from the inner tube, wherein the inner tube is formed from a first material
and the distal tip member is formed from a second material harder than the first material, the distal tip member being attached
to a distal end of the inner tube such that an axial lumen of the distal tip member is in fluid communication with the inner
tube axial lumen, and such that the distal tip member translates and rotates relative to the outer tube along with the inner
tube during operation of the tissue removal device so that a distal facing open cutting end of the distal tip member in fluid
communication with the axial lumen of the distal tip member translates across the tissue resection window of the outer tube
to sever tissue extending therethrough,

wherein an outer diameter of the distal tip member is greater than an outer diameter of the inner tube.

US Pat. No. 10,111,631

SYSTEM AND METHOD FOR GENERATING AND DISPLAYING TOMOSYNTHESIS IMAGE SLABS

HOLOGIC, INC., Marlborou...

1. A system for processing breast tissue images, comprising:an image processing computer; and
a user interface operatively coupled to the image processing computer,
wherein the image processing computer is configured to
obtain image data of breast tissue,
process the image data to generate a set of reconstructed image slices, the reconstructed image slices collectively depicting the breast tissue, and
process respective subsets of the reconstructed image slices to generate a set of image slabs, each image slab comprising a synthesized 2D image of a portion of the breast tissue obtained from a respective subset of the set of reconstructed image slices, wherein the respective 2D synthesized image does not correspond to an image that was acquired during imaging of the breast tissue.
US Pat. No. 10,085,955

METHODS AND COMPOSITIONS FOR TREATMENT OF DEMYELINATING DISEASES

Pathologica LLC, San Fra...

1. A method of treatment of progressive multiple sclerosis in a patient, comprising the administration to the patient, in need thereof, of a therapeutically effective amount of MGBG.

US Pat. No. 9,782,135

X-RAY MAMMOGRAPHY AND/OR BREAST TOMOSYNTHESIS USING A COMPRESSION PADDLE

Hologic, Inc., Marlborou...

1. An x-ray breast imaging system comprising:
a compression paddle comprising:
a front wall configured to be adjacent and face a chest wall of a patient during imaging, wherein the front wall comprises
a top;

a bottom wall configured to extend away from the patient's chest wall and to be adjacent a length of a top of a compressed
breast, wherein the bottom wall comprises a central portion, two outer edge portions, a first bottom portion distal the front
wall, and a second bottom portion disposed between the first bottom portion and the front wall,

wherein the first bottom portion comprises a first portion height from the top and wherein the second bottom portion comprises
a second portion height from the top, and

wherein the first portion height is less than the second portion height, and
wherein the compression paddle is movable; and
a first axis substantially orthogonal to the front wall.

US Pat. No. 9,940,738

SYSTEM AND METHOD FOR REDUCING DATA TRANSMISSION VOLUME IN TOMOSYNTHESIS

HOLOGIC, INC., Marlborou...

1. A method for processing and communicating breast tissue image data, comprising:obtaining image data of a patient's breast tissue, the obtained image data having an acquired image resolution;
processing the image data to form a first subset thereof, wherein the first subset of image data is configured to generate one or more lower resolution images of at least a portion of the patient's breast tissue, the one or more lower resolution images having a resolution lower than the acquired image resolution;
transmitting the first subset of the image data to a user computer;
receiving, from the user computer, a user request for higher resolution images of the patient's breast tissue that include a user identified feature, object or region in the one or more lower resolution images;
in response to the received user request, further processing the image data to form a second subset thereof, wherein the second subset of the image data is configured to generate one or more higher resolution images of the patient's breast tissue that include the user identified feature, object or region, the one or more higher resolution images having a resolution that is higher than the resolution of the one or more lower resolution images; and
transmitting the second subset of the image data to the user computer.

US Pat. No. 9,805,507

SYSTEM AND METHOD FOR NAVIGATING A TOMOSYNTHESIS STACK USING SYNTHESIZED IMAGE DATA

HOLOGIC, INC, Marlboroug...

1. A method for processing, displaying and navigating breast tissue images, comprising:
obtaining a plurality of 2D and/or 3D images of a patient's breast, wherein respective images of the obtained plurality of
images contain one or more regions defined by X,Y coordinate locations that are common for multiple images of the plurality;

generating a synthesized 2D image of the patient's breast by importing respective regions from the obtained plurality of images
into a merged image, wherein an image from which a respective region is imported into the merged image comprises a source
image for that region, wherein the imported regions are incorporated into the merged image at X,Y coordinate locations corresponding
to X,Y coordinate locations of the respective regions in their source image, and wherein one of each said one or more common
regions is imported from the plurality of images into the merged image based upon a comparison of one or more attributes of
the common region in each image that contains the respective common image;

displaying the synthesized 2D image;
receiving a user command, or otherwise detecting through a user interface, a user selection or other indication of a region
or of an object at least partially contained in said region in the displayed synthesized 2D image; and

displaying at least a portion of one or more source images of the user selected or indicated region or object.

US Pat. No. 9,549,709

INTEGRATED MULTI-MODE MAMMOGRAPHY/TOMOSYNTHESIS X-RAY SYSTEM AND METHOD

Hologic, Inc., Marlborou...

1. A breast tomosynthesis system comprising:
an arm assembly;
an x-ray source rotatably connected to the arm assembly;
a compression paddle comprising a front end and a rear end;
a biasing mechanism connecting the compression paddle to the arm assembly, wherein the biasing mechanism is configured to
cause the front end of the compression paddle to tilt about a connection axis disposed proximate a connection of the compression
paddle and the arm assembly; and

a controller for controlling the x-ray source in a plurality of imaging modes, wherein the x-ray source is configured to rotate
relative to the compression paddle about an axis for at least one of the plurality of imaging modes.

US Pat. No. 10,130,389

UTERINE FIBROID TISSUE REMOVAL DEVICE

HOLOGIC, INC., Marlborou...

1. A uterine fibroid tissue removal device, comprising:a housing;
an outer tube having a distal end and a proximal end, the proximal end of the outer tube supported by the housing, the outer tube configured for transcervical insertion into a uterus and having a tissue resection window located proximate to the distal end of the outer tube, the tissue resection window having a longitudinally oriented length;
an inner tube disposed within the outer tube and configured to be translated and rotated relative to the outer tube during operation of the tissue removal device, the inner tube having an axial lumen; and
a unitary distal tip member formed separately from the inner tube, wherein the inner tube is formed from a first material and the distal tip member is formed from a second material harder than the first material, the distal tip member being attached to a distal end of the inner tube such that an axial lumen of the distal tip member is in fluid communication with the axial lumen of the inner tube, and such that the distal tip member translates and rotates relative to the outer tube along with the inner tube during operation of the tissue removal device so that a distal facing open cutting end of the distal tip member in fluid communication with the axial lumen of the distal tip member translates across the tissue resection window of the outer tube to sever tissue extending therethrough,
wherein the axial lumen of the distal tip member is smaller in cross-sectional area than the axial lumen of the inner tube.

US Pat. No. 10,098,601

X-RAY BREAST TOMOSYNTHESIS ENHANCING SPATIAL RESOLUTION INCLUDING IN THE THICKNESS DIRECTION OF A FLATTENED BREAST

Hologic, Inc., Marlborou...

1. An x-ray breast imaging system comprising:a breast immobilizer configured to flatten a patient's breast;
an x-ray source and an x-ray imaging receptor configured to image the breast in an enhanced tomosynthesis mode ET in which the receptor obtains a first set of two-dimensional (2D) projection tomosynthesis x-ray images ETp1 for a first trajectory of the source around the immobilizer and a second set of images ETp2 for a longer second trajectory of the source around the immobilizer;
a computer-implemented image processor configured to apply tomosynthesis image reconstruction processing to the images ETp1 and ETp2 to obtain reconstructed images ETr, wherein one of the sets of (i) ETp1 images and (ii) ETp2 images contributes more high spatial frequency content than the other set to the reconstructed images ETr, and the images Etr represent respective breast slices having selected thicknesses and orientations; and
a display configured to display images related to said 3D reconstructed images ETr.

US Pat. No. 10,008,184

SYSTEM AND METHOD FOR GENERATING A 2D IMAGE USING MAMMOGRAPHY AND/OR TOMOSYNTHESIS IMAGE DATA

Hologic, Inc., Marlborou...

1. A method, comprising:obtaining a plurality of images, each of the images in the plurality having at least one corresponding region;
generating a merged image, the merged image also having the at least one corresponding region, wherein the merged image is a synthesized 2D image that is generated by selecting an image source from the plurality of images to source image data for the at least one corresponding region in the merged image by comparing attributes of the at least one corresponding region in each of the plurality of images to identify the image source having preferred attributes;
generating a map for a user-selected region in the merged image, whereby the map identifies at least one of the plurality of images that sourced the user-selected region in the merged image; and
displaying the at least one of the plurality of images that sourced the user-selected region when the user-selected region is selected by a user.

US Pat. No. 9,872,694

TISSUE REMOVAL SYSTEM

HOLOGIC, INC., Marlborou...

1. A tissue removal system, comprising:
an outer tubular member having a closed distal end and a tissue resection window proximal to the distal end;
an inner tubular member disposed within the outer tubular member and configured to translate axially relative to the outer
tubular member, wherein the tissue resection window is closed-off by the inner tubular member when the inner tubular member
is in a distal position relative to the outer tubular member;

a housing coupled to a proximal end of the outer tubular member;
a reversible motor operatively coupled to the inner tubular member, such that activation of the motor causes the inner tubular
member to translate axially relative to the outer tubular member;

a motor control switch disposed within the housing, wherein a structure coupled to the inner tubular member contacts the motor
control switch when the inner tubular member translates axially to the distal position relative to the housing; and

motor control circuitry operatively coupled to the motor control switch and the motor, the motor control circuitry including
an impedance monitor that monitors an impedance of a circuit including the motor control switch and detects when the motor
control switch is contacted by detecting a change in impedance not caused by a presence of saline in the circuit, and wherein
the motor control circuitry is configured for causing the motor to reverse when the impedance monitor detects that the motor
control switch is contacted.

US Pat. No. 9,844,363

BIOPSY DEVICE WITH ASPIRATION VALVE

Hologic, Inc., Marlborou...

1. A biopsy system, comprising:
(a) an instrument set, the instrument set comprising
an instrument set housing,
an elongate outer cannula having an axial lumen, a proximal portion coupled to the instrument set housing, and a distal portion
having a tissue receiving aperture in a side wall thereof in communication with the lumen,

an elongate inner cannula disposed within the outer cannula lumen, an aspiration vent disposed within the instrument set housing,
wherein the aspiration vent fluidly couples the outer cannula lumen to atmosphere through an aspiration vent opening,

an aspirate valve assembly interposed in the aspiration vent, the aspirate valve assembly including a sealing member configured
to seal the aspiration vent opening, and

an interference member that may be selectively moved at least partially into the aspiration vent opening to thereby contact
the sealing member and prevent the sealing member from sealing the aspiration vent opening: and

(b) an instrument drive removably coupled to the instrument set, the instrument drive comprising
an instrument drive housing removably coupled to the instrument set housing,
a motorized inner cannula driver disposed within the instrument drive housing and configured to axially oscillate the inner
cannula relative to the outer cannula during operation of the biopsy system, such that an open distal end of the inner cannula
moves back and forth across the tissue receiving aperture to sever tissue extending therethrough, and

an actuating member disposed within the instrument drive housing, wherein the actuating member is configured to selectively
move the interference member at least partially into the vent opening to thereby prevent the sealing member from sealing the
aspiration vent opening.

US Pat. No. 10,105,709

SYSTEM AND METHOD FOR MULTI-AXIS IMAGING OF SPECIMENS

Hologic, Inc., Marlborou...

1. A method of imaging a specimen, comprising:elastically deforming first and second retention members of a positioning apparatus to surround opposing portions of a specimen;
securing the first and second retention members against movement relative to each other to retain the specimen therebetween, wherein a reference plane extends between the first and second retention members when the specimen is retained therebetween;
generating, at a source of electromagnetic radiation, a beam of electromagnetic radiation;
sending, while the specimen is retained between the first and second retention members, the beam along an imaging axis through the specimen and the first and second retention members; and
receiving the beam at an imaging detector, wherein the beam is free of contact with any structures other than the specimen and the first and second retention members along the imaging axis between the source and the imaging detector.

US Pat. No. 9,952,301

SYSTEM AND METHOD FOR SELECTING AND MODIFYING A HANGING PROTOCOL FOR DISPLAYING MRI INFORMATION

Hologic, Inc., Marlborou...

1. A system for analyzing MRI image data and displaying MRI images, comprising:an image processing computer; and
at least one image display monitor,
wherein the image processing computer is programmed or otherwise configured to
(i) analyze MRI image data to identify characteristics of an image acquisition protocol used to acquire the MRI image data,
(ii) determine differences between the identified characteristics of the image acquisition protocol and characteristics corresponding to a default image hanging protocol, and
(iii) if each of the determined differences is within a respective predetermined buffer range, cause a plurality of MRI images obtained from the MRI image data to be displayed on the at least one image display monitor in accordance with the default image hanging protocol.

US Pat. No. 9,913,629

TISSUE REMOVAL SYSTEM

HOLOGIC, INC., Marlborou...

1. A tissue removal device for acquiring one or more samples of intrauterine tissue from a patient, the tissue removal device
comprising:
a housing;
an outer tube having a distal portion configured for transcervical insertion into a uterus, the outer tube having an outer
tube lumen, a tissue in-take window proximate a closed distal end thereof, and a proximal end coupled to the housing;

an inner tube slidably disposed within the outer tube lumen, the inner tube having an inner tube lumen extending from an open
inner tube distal end to an open inner tube proximal end, wherein the open inner tube distal end severs intrauterine tissue
extending through the tissue in-take window in the outer tube when the inner tube moves from a window open position to a window-closed
position;

a vacuum generation chamber disposed within the housing;
a movable piston slidably disposed in the vacuum generation chamber, so that the piston forms a wall of the vacuum chamber,
wherein the inner tube lumen is selectively placed in fluid communication with the vacuum generation chamber via a distal
one-way valve, the distal one-way valve being oriented so that material located in the inner tube lumen may be aspirated from
the inner tube lumen into the vacuum generation chamber in response to movement of the piston in a distal direction, while
material in the vacuum generation chamber is prevented by the distal one-way valve from entering the inner lumen;

a collection chamber, wherein the vacuum generation chamber is selectively placed in fluid communication with the collection
chamber via a proximal one-way valve, the proximal one-way valve being oriented so that material located in the vacuum generation
chamber may be expelled from the vacuum generation chamber into the collection chamber in response to movement of the piston
in a proximal direction, while material in the collection chamber is prevented from entering the vacuum generation chamber;
and

a manual actuator moveably coupled to the housing and operatively coupled to the piston, wherein movement of the actuator
relative to the housing causes movement of the piston within the vacuum generation chamber.

US Pat. No. 9,913,681

ABLATION DEVICE USING BIPOLAR STEAM GENERATION

HOLOGIC, INC., Marlborou...

1. An intrauterine ablation device, comprising:
a working end configured for transcervical insertion into, and to thereafter be expanded within, a patient's uterus, the working
end comprising a permeable spacer, the permeable spacer having an outward-facing surface and an inward-facing surface, wherein
when the working end is inserted into and expanded within the patient's uterus, the inward-facing surface of the permeable
spacer defines an interior region; and

an electrode assembly disposed within the interior region defined by the inward-facing surface of the permeable spacer, the
electrode assembly including

a first electrode comprising a generally planar permeable body having an inward-facing surface,
a second electrode comprising a generally planar permeable body having an inward-facing surface facing the inward-facing surface
of the first electrode, and

a layer of absorbent material disposed between the inward-facing surfaces of the first and second electrodes, the absorbent
material being configured to absorb a conductive fluid so as to electrically couple the first electrode to the second electrode
when a current is provided to one of the first or second electrodes.

US Pat. No. 9,907,691

INTRAUTERINE CONTRACEPTIVE DEVICES

HOLOGIC, INC., Marlborou...

1. A contraceptive intrauterine device, comprising:
a support structure configured for transcervical implantation in a uterus,
an active element coupled to the support structure, the active element comprising a copper core that is at least partially
plated or coated with an outer layer comprising gold or gold alloy, wherein the copper core is configured to release copper
ions after the device is implanted in a uterus, and wherein the gold or gold alloy outer layer is configured to control the
release rate of copper ions release by the core.

US Pat. No. 9,901,320

SYSTEM AND METHOD FOR FUSING THREE DIMENSIONAL IMAGE DATA FROM A PLURALITY OF DIFFERENT IMAGING SYSTEMS FOR USE IN DIAGNOSTIC IMAGING

Hologic, Inc., Marlborou...

1. A method of examining a breast of a patient includes the steps of:
immobilizing the breast, and while the breast is immobilized:
acquiring a three dimensional image of the breast using a first imaging modality, wherein the three dimensional image of the
breast acquired using the first imaging modality has a first co-ordinate space;

selecting a region of interest (ROI) in a three dimensional volume based on the three dimensional image, the step of selecting
including identifying coordinates of the ROI in the three dimensional volume;

acquiring a plurality of images of the breast using a second imaging modality through a manually-manipulable imaging probe,
wherein the plurality of images of the breast acquired using the second imaging modality have a second co-ordinate space,
the second co-ordinate space different than the first co-ordinate space;

tracking a movement of an imaging probe of the second imaging modality so as to obtain a second co-ordinate data of the second
co-ordinate space, wherein tracking the movement of the imaging probe is performed during acquisition of the plurality of
images of the breast with the second imaging modality;

co-registering the second coordinate data with the first co-ordinate space via a navigation system, the navigation system
configured to transform a position and orientation of a field of view of the imaging probe of the second imaging modality
so that the navigation system co-registers the second coordinate data with the three dimensional image;

during manual manipulation of the imaging probe during acquisition of the plurality of images of the breast with the second
imaging modality, providing a cue indicating that the imaging probe is approaching the ROI identified in the three dimensional
volume based on the co-registered second coordinate data and the three-dimensional image acquired by the first imaging modality;
and

releasing the breast from immobilization.

US Pat. No. 9,872,659

INDEPENDENTLY ROTATABLE DETECTOR PLATE FOR MEDICAL IMAGING DEVICE

HOLOGIC, INC., Marlborou...

1. A fluoroscopic imaging device comprising:
a c-arm support assembly;
an x-ray source assembly mounted at a first distal end of the c-arm support assembly;
a detector assembly rotatably mounted to a second distal end of the c-arm support assembly, wherein the detector assembly
is configured to rotate independently of the c-arm support assembly; and

a collimator assembly rotatably mounted to the first distal end of the c-arm support assembly, wherein a plane of rotation
of the collimator assembly matches a plane of rotation of the detector assembly, and the collimator assembly is configured
to automatically match a manual rotation of the detector assembly to maintain an orientation of the collimator assembly with
the detector assembly.

US Pat. No. 9,616,035

PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE

PATHOLOGICA, LLC, San Fr...

1. A method of treating, or delaying the onset or development of, multiple sclerosis, comprising administering to a subject
in need thereof about 25 mg/day to about 350 mg/day of an oral pharmaceutical composition comprising MGBG and at least one
pharmaceutically acceptable excipient.

US Pat. No. 9,579,524

FLEXIBLE MULTI-LUMEN BRACHYTHERAPY DEVICE

Hologic, Inc., Marlborou...

12. An apparatus for treating a proliferative disorder in a patient comprising:
a rigid member fixed at a distal end of the apparatus, the rigid member having a proximal end, a distal end and a plurality
of openings within an interior of the rigid member extending longitudinally from a proximal end of the rigid member towards
a distal end of the rigid member such that access to the plurality of openings is solely at the proximal end of the rigid
member and the distal end of the rigid member;

an inflatable member enveloping at least a portion of the rigid member, the inflatable member spaced apart from a proximal
end of the apparatus such that the inflatable member does not envelop the proximal end of the apparatus;

a plurality of separate dosing lumens, each having a proximal end and a distal end, wherein each distal end of each dosing
lumen extends into a different one of the plurality of openings of the rigid member and wherein the rigid member provides
a sole, fixed attachment point for securing the plurality of dosing lumens to the apparatus at the distal end of the apparatus
and for restricting movement of the plurality of dosing lumens at the sole attachment point about any degree of freedom relative
to the apparatus;

a hub disposed remote from the rigid member and positioned between the distal ends and proximal ends of the dosing lumens,
the hub having a hole extending therethrough sized to slideably accommodate the plurality of dosing lumens to thereby allow
individualized movement of the plurality of dosing lumens through the hub; and

a catheter sleeve coupled between a distal end of the hub and a proximal end of the rigid member, the catheter sleeve sized
to encase the plurality of dosing lumens while allowing individual movement of the plurality of dosing lumens.

US Pat. No. 10,022,557

USING A GUIDED MEMBER TO FACILITATE BRACHYTHERAPY DEVICE SWAP

Hologic, Inc., Marlborou...

1. An apparatus for facilitating brachytherapy treatment comprising:an elongated guide member comprising a guide wire and a non-inflatable anchor member at a distal end of the guide wire, wherein the non-inflatable anchor member comprises a curvature; and
a device comprising:
a shaft defining a lumen configured to slidably receive the elongated guide member;
a tip disposed at a first end of the shaft, wherein the tip comprises an outer curvature configured to mate with the non-inflatable anchor curvature when the elongated guide member is received in the lumen;
an inflatable member disposed around the shaft;
an inflation lumen which transfers fluid into and out of the inflatable member; and
an opening in the tip which receives the elongated guide member, and via which the elongated guide member can be introduced to soft tissue, wherein the opening is sized so as to receive all but the non-inflatable anchor member of the elongated guide member.

US Pat. No. 10,016,184

BIOPSY DEVICE WITH AUTOMATIC BIOPSY PARAMETER ADJUSTMENT

Hologic, Inc., Marlborou...

1. A biopsy system, comprising:a support structure;
an elongate cannula coupled to and extending from the support structure, the cannula having a distal portion with a tissue receiving aperture in a side wall thereof;
an axially oscillating cutter disposed in an axial lumen of the cannula; and
an introducer, wherein the support structure is configured for providing releasable attachment of the introducer to the support structure over the cannula in a first attachment configuration, and in a second attachment configuration, wherein in at least one of the first and second attachment configurations the tissue receiving aperture is partially obscured by the introducer, and wherein an oscillation stroke length of the cutter when the introducer is attached to the support structure in the first attachment configuration is greater than an oscillation stroke length of the cutter when the introducer is attached to the support structure in the second attachment configuration.

US Pat. No. 9,937,016

BREAST BIOPSY LATERAL ARM SYSTEM

HOLOGIC, INC., Marlborou...

1. A breast biopsy system comprising:a lateral member, wherein the lateral member has a longitudinal axis, the lateral member being slidably mounted on a post member of a biopsy guidance module;
a slide assembly, wherein the slide assembly is slidably mounted on the lateral member, wherein the slide assembly has a longitudinal axis and wherein the longitudinal axis of the slide assembly is generally parallel to the longitudinal axis of the lateral member; and
a gun mount configured to support a biopsy gun, the gun mount being alternatively mountable on the slide assembly in a plurality of different orientations and being connected to the lateral member via the slide assembly, wherein the gun mount is movable by sliding the slide assembly on the lateral member along a first axis with respect to the lateral member, the first axis being along an insertion direction of the biopsy gun into a patient.

US Pat. No. 9,763,633

DISPLAYING COMPUTER-AIDED DETECTION INFORMATION WITH ASSOCIATED BREAST TOMOSYNTHESIS IMAGE INFORMATION

Hologic, Inc., Marlborou...

1. A computer-implemented method for processing and displaying information associated with breast x-ray images, comprising:
acquiring or receiving x-ray image data of a breast; and
computing a fibroglandular tissue density map of the breast based at least in part on information associated with the acquired
or received x-ray image data of the breast, the fibroglandular tissue density map characterizing each location therein by
a fibroglandular tissue density metric representative of an absolute proportion, by volume, of fibroglandular breast tissue
in a local neighborhood of that location,

wherein the acquired or received x-ray image data comprises a breast x-ray tomosynthesis volume computed from a plurality
of x-ray tomosynthesis projection images, the breast x-ray tomosynthesis volume comprising a plurality of two-dimensional
breast x-ray tomosynthesis reconstructed image slices corresponding to a respective plurality of slice depths in the breast
volume, and wherein the fibroglandular tissue density map is a three-dimensional map, and

wherein the fibroglandular tissue density map is computed by
processing at least two of the x-ray tomosynthesis projection images to compute, for each of the at least two processed x-ray
tomosynthesis projection images, a respective two-dimensional volumetric breast density (VBD) map according to a predetermined
VBD computation algorithm, the VBD map containing, for each location in the respective x-ray tomosynthesis projection image,
information representative of an absolute cumulative height of the fibroglandular breast tissue and an absolute cumulative
height of non-fibroglandular breast tissue in a correspondingly located column of breast tissue; and

processing the at least two VBD maps to generate the three-dimensional fibroglandular tissue density map.

US Pat. No. 9,646,376

SYSTEM AND METHOD FOR REVIEWING AND ANALYZING CYTOLOGICAL SPECIMENS

HOLOGIC, INC., Marlborou...

1. A computer-assisted method of navigating images of a cytological specimen, comprising the acts of:
analyzing a first image of the cytological specimen to identify an object of interest within the cytological specimen;
displaying a second image of the object of interest to a user; and
in response to receiving a user selection of the object of interest:
determining a first characteristic of the selected object of interest;
receiving, from the user, a range of values corresponding to a second characteristic of the selected object of interest;
evaluating one or more objects of interest to determine at least one other object of interest having a similar characteristic
to the first characteristic of the selected object of interest and having a second characteristic measurement within the range
of values; and

displaying, responsive to determining the at least one other object of interest, a third image of the selected object of interest
and a fourth image of the at least one other object of interest so as to provide for comparison of the objects of interest
by the user.

US Pat. No. 10,108,329

IMAGE HANDLING AND DISPLAY IN X-RAY MAMMOGRAPHY AND TOMOSYNTHESIS

Hologic, Inc., Marlborou...

1. An image display system for reviewing medical images for abnormalities in a compressed breast, comprising:a displayed image comprising at least one image of a plurality of tomosynthesis images of the compressed breast;
a slider bar for identifying a height within the compressed breast corresponding to the displayed image, wherein the slider bar comprises a length; and
a slice bar movably positionable along the length of the slider bar, wherein a position of the slice bar along the length of the slider bar corresponds to a height of the displayed image within the compressed breast, wherein the slice bar comprises an adjustable thickness, and wherein a thickness of the slice bar corresponds to a thickness of the displayed image within the compressed breast, thereby providing an adjustable display of tomosynthesis images for reviewing medical images for abnormalities in the compressed breast.

US Pat. No. 10,004,553

POWER MODULATED ENDOMETRIAL LINING TISSUE ABLATION

Hologic, Inc., Marlborou...

1. A method of ablating endometrial lining tissue, comprising:delivering radiofrequency (RF) power to endometrial lining tissue of a uterine cavity;
measuring an initial impedance of the endometrial lining tissue after RF power has been delivered for a predetermined initial time period;
scaling a predetermined endometrial lining tissue ablation impedance curve based upon the measured initial impedance, the predetermined endometrial lining tissue ablation impedance curve having an endpoint corresponding to reaching a target maximum tissue impedance at a target ablation procedure completion time;
determining a target tissue impedance as a function of time based on the scaled predetermined endometrial lining tissue ablation impedance curve; and
modulating the delivery of RF power so that impedance of the endometrial lining tissue tracks the target tissue impedance as a function of time.

US Pat. No. 9,642,585

BONE DENSITOMETER

HOLOGIC, INC., Marlborou...

1. A method comprising:
moving a radiation source and a radiation detector along a first scan path substantially transverse to a longitudinal axis
of a patient, wherein the first scan path is a single path transversely across a first femur and a second femur of the patient;

emitting a first beam of radiation from the radiation source during movement along the first scan path;
detecting the first beam of radiation at the radiation detector during movement along the first scan path;
processing the detected beam so as to form a first image of a first area of the patient along the scan path, wherein the first
area includes both the first femur and the second femur;

identifying a region in the first image;
moving the radiation source and the radiation detector along a region scan path corresponding to the identified region;
emitting a region beam of radiation from the radiation source during movement along the region scan path; and
detecting the region beam of radiation at the radiation detector during movement along the region scan path.

US Pat. No. 10,271,807

INDEPENDENTLY ROTATABLE DETECTOR PLATE FOR MEDICAL IMAGING DEVICE

HOLOGIC, INC., Marlborou...

1. A fluoroscopic imaging device, comprising:an x-ray source assembly comprising a collimator;
a rotatable flat detector assembly separated by a gap from the x-ray assembly, and wherein a plane of rotation of the detector assembly matches a plane of rotation of the collimator, and the detector assembly is configured to automatically match a manual rotation of the collimator to maintain an orientation of the detector assembly with the x-ray source assembly.
US Pat. No. 10,215,760

DETECTION OF INTRAAMNIOTIC AND/OR INFECTION

Hologic, Inc., Marlborou...

1. A method of diagnosing intra-amniotic infection in a pregnant female mammalian subject comprising:(a) obtaining a test a sample of cervical-vaginal fluid from the subject, wherein the pregnant female mammalian subject has intact membranes, is in pre-term labor, and is from about 22 weeks to about 36 weeks gestation;
(b) detecting the levels of interleukin-6 (IL-6) and alpha-fetoprotein (AFP) in the test cervical-vaginal fluid sample by contacting the sample with detecting agents specific for IL-6 and AFP and detecting binding between the detecting agents and the IL-6 and AFP proteins;
(c) diagnosing said subject with intra-amniotic infection when each of said levels of each of said proteins in said sample is determined to show a statistically significant difference relative to the corresponding levels of each of said proteins in said normal cervical-vaginal fluid; and
(d) performing amniocentesis on the diagnosed subject or treating said subject that is not diagnosed in step (c) for preterm labor.

US Pat. No. 10,201,317

PATIENT SUPPORT PADS FOR USE IN DETECTING LYMPHEDEMA THROUGH X-RAY SCANS

HOLOGIC, INC., Marlborou...

1. A system for use in examining a patient, the system comprising:a dual energy x-ray absorptiometry system comprising a computer and an x-ray source, wherein the dual energy x-ray absorptiometry system is configured to conduct a scan of at least a portion of a patient; and
at least one spacer disposed within a field of view of the dual energy x-ray absorptiometry system, the at least one spacer pad comprising two opposing surfaces, the at least one spacer pad being configured to be positioned between body parts of the patient, with one of the two opposing surfaces being in contact with a first body part of the patient and with the other of the two opposing surfaces being in contact with a second body part of the patient, whereby the at least one spacer pad keeps the first and second body parts from coming into contact with one another;
wherein the computer processes the scan acquired with the dual energy x-ray absorptiometry system and outputs information about the patient in which a delineation is made between the first and second body parts spaced apart by the at least one spacer pad.

US Pat. No. 10,181,045

AUTOMATED EMAIL MESSAGE AND DOCUMENT SHREDDING SYSTEM

Hologic, Inc., Marlborou...

1. A system comprising:at least one processor; and
memory coupled to the at least one processor, the memory comprising computer executable instructions that, when executed by the at least one processor, performs a method of sending self-terminating content, the method comprising:
generating content;
in response to generating the content, determining a condition for terminating the content;
determining a security context, wherein the determination of the security context is based at least in part on the condition;
based on the security context, determining a security key to associate with the content;
applying the security key to the content using One-Time Pad (OTP) encryption to generate encrypted content;
sending to a recipient computing device the encrypted content, a notification of the security key and a notification of the condition, wherein the encrypted content sent to the recipient computing device self-terminates upon satisfaction of the condition, and
wherein the security key is accessible to a sender computing device sending the content and the recipient computing device prior to sending the self-terminating content.

US Pat. No. 10,152,206

DISPLAYING AND NAVIGATING COMPUTER-AIDED DETECTION RESULTS ON A REVIEW WORKSTATION

HOLOGIC, INC., Marlborou...

1. A computer-implemented method for displaying computer-aided detection (CAD) detections associated with a tomosynthesis case, the tomosynthesis case comprising a plurality of tomosynthesis images that are processed by a CAD algorithm to identify CAD detections therein based at least in part upon respective computed features associated with respective CAD detections, each CAD detection being associated with a location in a tomosynthesis image of the tomosynthesis case, the method comprising:displaying one or more of the plurality of tomosynthesis images, the displayed one or more tomosynthesis images each including one or more respective CAD markers corresponding to locations of CAD detections in the tomosynthesis case;
displaying an expanded presentation window of a location in a displayed tomosynthesis image in response to receiving a user selection of a respective CAD marker in the displayed tomosynthesis image; and
displaying the expanded presentation window for the location in the tomosynthesis image associated with the CAD detection corresponding to the selected CAD marker, wherein the expanded presentation window is displayed over the location in the tomosynthesis image.

US Pat. No. 10,117,710

ENDOMETRIAL LINING TISSUE TREATMENT DEVICE

Hologic, Inc., Marlborou...

1. An endometrial tissue treatment device, comprising:an elongate positioning member; and
an energy applicator coupled to a distal end of the positioning member,
the energy applicator comprising a tissue contacting member and an expandable-collapsible support structure underlying the tissue contacting member,
the expandable-collapsible support structure comprising a substantially non-compliant elongate balloon disposed within a distal portion of the tissue contacting member that, when inflated within a uterus, has a lengthwise dimension oriented substantially transverse to the positioning member that spans a fundal wall of the uterus extending between a first corner portion of the tissue contacting member positioned in a first cornu of the uterus and a second corner portion of the tissue contacting member positioned in a second cornu of the uterus, such that the tissue contacting member is disposed between a distal facing surface of the inflated balloon and the fundal wall of the uterus, the inflated balloon having a widthwise dimension transverse to the lengthwise dimension, wherein the widthwise dimension of the inflated balloon is less than half the lengthwise dimension.

US Pat. No. 10,104,319

DECORRELATED CHANNEL SAMPLING FOR DIGITAL IMAGING

HOLOGIC, INC., Marlborou...

1. An apparatus comprising:a device that generates a portion of an image from a plurality of columns within a first row by sampling each column during a sampling time corresponding to the column; and
circuitry that offsets sampling times of at least first and second columns within the first row, thereby reducing noise correlation between the first and second columns in the first row, wherein the circuitry includes:
a first charge amplifier associated with the first column; and
a second charge amplifier associated with the second column, wherein the second charge amplifier is different from the first charge amplifier and wherein each of the first charge amplifier and the second charge amplifier has an input with a dedicated, programmable delay line.

US Pat. No. 10,092,358

TOMOSYNTHESIS-GUIDED BIOPSY APPARATUS AND METHOD

Hologic, Inc., Marlborou...

1. An apparatus comprising:a table comprising a base for supporting a patient in a prone position, wherein the table extends substantially along an X-dimension and a Y-dimension, and the base extends substantially along a Z-dimension, each dimension being substantially orthogonal to one another;
an equipment support platform coupled to the base by one or more slide assemblies, wherein the equipment support platform extends from the base and is disposed below the table, and wherein the equipment support platform is configured to slide relative to the base along the X-dimension, the Y-dimension, and the Z-dimension;
a tomosynthesis imaging system for imaging a breast of the patient, the tomosynthesis imaging system comprising an imaging support platform pivotally connected to the equipment support platform and supporting an x-ray source and a receptor, wherein the tomosynthesis imaging system is rotatable about a rotation axis parallel to the Z-dimension and defined between the x-ray source and the receptor;
a stage arm assembly for obtaining a tissue sample from the breast of the patient imaged by the tomosynthesis imaging system, the stage arm assembly comprising a stage arm support platform connected to the equipment support platform and configured to support a biopsy needle; and
a breast support assembly for compressing the breast of the patient, the breast support assembly comprising a breast support platform connected to the equipment support platform and supporting a compression paddle and a breast platform.

US Pat. No. 10,271,826

SWAB ASSEMBLY FOR SPECIMEN COLLECTION

HOLOGIC, INC., Marlborou...

1. A swab assembly for collecting a specimen from a human urethra, comprising:an elongated shaft having a proximal end and a distal end, the elongated shaft having a notch therein between its proximal and distal ends;
a sheath having a proximal end and a distal end, the sheath defining a lumen extending between its proximal and distal ends, wherein at least a portion of the elongated shaft is disposed within the sheath lumen, and the sheath is slidable relative to the elongated shaft, the sheath being sized and shaped for insertion into a human urethra; and
a compressible collection tip coupled to the distal end of the elongated shaft and configured for obtaining the specimen,
wherein the sheath is slidable between a first position in which the shaft notch is disposed within the sheath lumen and wherein the sheath protects the elongated shaft from breaking at the notch, and a second position in which the shaft notch is exposed out of the sheath lumen, and wherein the sheath does not protect the elongated shaft from breaking at the notch,
wherein the collection tip is configured to be compressed and positioned entirely within the sheath lumen during insertion of the sheath into the urethra, and
wherein the collection tip expands when the collection tip is exposed out of the sheath lumen when the sheath is positioned at or near a specimen collection site within the urethra.

US Pat. No. 10,265,041

UPRIGHT X-RAY BREAST IMAGING WITH A CT MODE, MULTIPLE TOMOSYNTHESIS MODES, AND A MAMMOGRAPHY MODE

HOLOGIC, INC., Bedford, ...

1. A system for imaging a breast of an upright patient with x-rays comprising:a breast compression unit configured to at least partially compress a breast of an upright patient between a pair of compression surfaces;
an x-ray data acquisition unit configured to operate the system in:
a computerized tomography (CT) mode to thereby generate a plurality of CT x-ray projection images CTp of the breast taken at different angles to the breast; and
a tomosynthesis mode T to thereby generate a plurality of tomosynthesis x-ray projection images Tp of the breast taken at different angles to the breast; and
an image processing unit configured to computer-process the images CTp to thereby generate a reconstructed image CTr and to computer process the images Tp to thereby generate tomosynthesis reconstructed breast slice images Tr of at least a portion of the breast.

US Pat. No. 10,263,968

SECURITY MEASURE FOR EXCHANGING KEYS OVER NETWORKS

Hologic Inc., Bedford, M...

1. A method of exchanging keys within a peer-to-peer network, the method comprising:generating a first key, at a first computing device, for encrypting and decrypting content that is communicated between the first computing device and at least a second computing device, wherein the first key is generated using a stream of bits;
assigning a security measure value to the first key, wherein the security measure value indicates a level of security associated with transmitting the first key over the peer-to-peer network;
transmitting a copy of the first key over the peer-to-peer network to at least the second computing device;
in response to transmitting the copy of the first key over the peer-to-peer network, updating the security measure value of the first key based on a first condition based on transmitting the copy of the first key over the peer-to-peer network, wherein the first condition is based on at least one of: a type of network over which the copy of the first key is transmitted, a type of method used to transmit the copy of the first key, a type of computing device that generated the first key, or a time stamp associated with the first key;
generating, at the first computing device, encrypted content using the first key based at least upon a desired security measure value of the first key; and
sending the encrypted content over a network to the second computing device; and
after a second condition based on expiring the copy of the first key has been satisfied, deleting the copy of the first key.

US Pat. No. 10,194,875

INTEGRATED MULTI-MODE MAMMOGRAPHY/TOMOSYNTHESIS X-RAY SYSTEM AND METHOD

Hologic, Inc., Marlborou...

1. A system for multi-mode breast x-ray imaging comprising:a compression arm assembly for compressing a patient's breast for x-ray imaging;
an x-ray image receptor;
an x-ray tube assembly, wherein the compression arm assembly, the x-ray tube assembly, and the x-ray image receptor are configured for movement about an axis to accommodate a plurality of imaging modes, and wherein the x-ray tube assembly is configured to rotate relative to the compression arm for at least a tomosynthesis imaging mode of the plurality of imaging modes; and
a patient shield secured to the compression arm assembly and spaced apart from the x-ray tube assembly, wherein during the tomosynthesis imaging mode the x-ray tube assembly is configured to rotate relative to at least a portion of the patient shield.

US Pat. No. 10,098,590

TABLE FOR PERFORMING MEDICAL PROCEDURES

HOLOGIC INC., Marlboroug...

1. An apparatus comprising:a table top including a rigid platform with an opening;
a plurality of interchangeable members positionable on the table top, each of the plurality of interchangeable members including a port through which a portion of a patient's body extends during a medical procedure, wherein the port is disposed above and aligns with the opening, wherein a first one of the interchangeable members includes a different size port than a second one of the interchangeable members, wherein when removably mounted on the table top, the plurality of the interchangeable members permit the portion of the patient's body to extend through the ports of the interchangeable members; and
a base including an upright pillar member connected to the table top, the pillar member being positioned to one side of the table top such that the table top is cantilevered and an area beneath the table top is accessible for positioning equipment for performing the medical procedure.

US Pat. No. 10,296,199

IMAGE HANDLING AND DISPLAY IN X-RAY MAMMOGRAPHY AND TOMOSYNTHESIS

Hologic, Inc., Marlborou...

1. A method of generating x-ray images of a breast, the method comprising:obtaining a plurality of tomosynthesis projection images of the breast; and
generating, from the tomosynthesis projection images, a plurality of tomosynthesis reconstructed images, wherein the plurality of tomosynthesis reconstructed images correspond to at least a partial thickness of the breast, wherein a first tomosynthesis reconstructed image of the plurality of tomosynthesis reconstructed images corresponds to a first portion of the at least partial thickness of the breast, and wherein a second tomosynthesis reconstructed image of the plurality of tomosynthesis reconstructed images corresponds to a second portion of the at least partial thickness of the breast, wherein the first portion is different than the second portion.
US Pat. No. 10,292,950

METHOD OF TREATMENT WITH ANTI-INFLAMMATORY AND ANALGESIC COMPOUNDS WHICH ARE GI-, RENAL-, AND PLATELET-SPARING

Pathologica LLC, San Fra...

1. A method of treatment of pain or inflammation in an elderly patient in need thereof, comprising administering a therapeutically effective amount of methylglyoxal bis(guanylhydrazone) (MGBG), wherein the therapeutically effective amount of MGBG does not inhibit cyclooxygenase and is not an opioid or a steroid, and is gastrointestinal-, platelet-, and renal-sparing.

US Pat. No. 10,315,015

CUFF-RESISTANT ANCHORING BALLOON FOR MEDICAL DEVICE

Hologic, Inc., Marlborou...

1. A medical device, comprising:an elongate support structure; and
an inflatable balloon, the balloon comprising a first-end portion secured to the support structure at a first location, a second-end portion secured to the support structure at a second location distal to the first location, and a middle-body portion,
the middle-body portion having a first end integrally formed with or otherwise bonded to the first-end portion, and a second end integrally formed with or otherwise bonded to the second-end portion,
the first-end portion having a wall thickness greater than a wall thickness of the middle-body portion, and
the respective first-end portion, middle-body portion and second-end portion collectively defining a sealed interior of the balloon through which the support structure extends,
wherein the balloon, when inflated to an inflation pressure and anchored in an anatomical body region, does not move relative to the support structure or otherwise cuff when the elongate support structure is subjected to a proximally directed axial force of approximately 0.5 pounds.