US Pat. No. 9,383,288

METHOD AND DEVICE FOR PROCESSING A TIME-DEPENDENT MEASUREMENT SIGNAL

Gambro Lundia AB, Lund (...

1. A device for processing a time-dependent measurement signal obtained from a pressure sensor in a fluid containing system
associated with a first pulse generator and a second pulse generator, wherein the pressure sensor is arranged in the fluid
containing system to detect a first pulse originating from the first pulse generator and a second pulse originating from the
second pulse generator, wherein the fluid containing system comprises an extracorporeal blood flow circuit for connection
to a blood system in a human body, wherein the first pulse generator comprises a pumping device in the extracorporeal blood
flow circuit, and wherein the second pulse generator comprises a physiological pulse generator in the human body, said device
comprising:
an input for the time-dependent measurement signal;
a signal processor connected to said input and comprising a processing module configured to obtain a first pulse profile which
is a predicted temporal signal profile of the first pulse, and to filter the time-dependent measurement signal in a time-domain
to output an error signal in which the first pulse is essentially eliminated while the second pulse is retained; and

an adaptive filter;
wherein the signal processor is further configured to: supply the first pulse profile as input to the adaptive filter; calculate
the error signal as a difference between the measurement signal and an output signal of the adaptive filter; and provide the
error signal as input to the adaptive filter, whereby the adaptive filter is arranged to essentially eliminate the first pulse
in the error signal.

US Pat. No. 9,216,248

METHOD AND A DEVICE FOR MONITORING A STATE OF A BLOOD LINE IN A MACHINE FOR EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. A method for detecting a presence of a partial or total occlusion in a blood line in a circuit for extracorporeal blood
treatment, comprising:
acquiring at least a first pressure value from a first sensor mounted at a first point of the circuit for extracorporeal blood
treatment, said circuit a blood line in which the blood is subjected to a pulsating thrust and a blood treatment device arranged
in the blood line, wherein a peristaltic pump is arranged upstream of the blood treatment device and upstream of a venous
chamber of the blood line in order to produce the pulsating thrust of the blood;

acquiring at least a second pressure value from a second sensor mounted at a second point, distinct from the first point,
of the blood line of the circuit for extracorporeal blood treatment, and

relating at least a first value, related to the first pressure value, and at least a second value, related to the second pressure
value, with at least a threshold value, to obtain a datum representing a state of partial or total occlusion in the blood
line in the circuit for extracorporeal blood treatment,

wherein the first pressure value is measured by a first sensor mounted in a hydraulic circuit for a blood treatment fluid
and wherein the second pressure value is measured by a second sensor mounted at the venous chamber of the blood line.

US Pat. No. 9,161,980

MEDICAL SOLUTION, A METHOD FOR PRODUCING SAID MEDICAL SOLUTION AND USE THEREOF

Gambro Lundia AB, Lund (...

1. A medical solution comprising:
a first single solution comprising bicarbonate and carbonate in a mass ratio of 1:2.91 to approximately 1:6 such that a partial
pressure of carbon dioxide in the first single solution is of the same order of magnitude as a partial pressure of carbon
dioxide in the atmosphere, and has a pH of 10.1-10.5; and

a second single solution comprising an acid,
wherein said first and second single solutions are mixed after terminal sterilization to form a final solution, wherein said
second single solution has a pH of 1.0-1.5 and said final solution has a pH of 7.0-7.6.

US Pat. No. 9,452,149

DIALYSIS COMPOSITION COMPRISING CITRATE, CALCIUM AND MAGNESIUM

Gambro Lundia AB, Lund (...

1. A dialysis composition comprising 0.5 to 3 mM citrate, 1 to 5 mM total calcium, and 0 to 1.5 mM total magnesium, wherein
the dialysis composition comprises [cit] mM citrate and [Ca]new mM total calcium, wherein
[Ca]new=[Ca]norm+(kCa·[cit]),

and wherein kca is within range of 0.10 to 0.2.

US Pat. No. 9,283,310

EXTRACORPOREAL BLOOD TREATMENT APPARATUS

GAMBRO LUNDIA AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising:
a blood treatment device having a blood chamber and a fluid chamber separated from one another by a semipermeable membrane;
an extracorporeal blood circuit having a removal line for sending blood from a patient to the blood chamber, and a return
line for returning the blood from the blood chamber to the patient;

a fluid circuit connected to the fluid chamber;
one or more sensors for measuring a value of a parameter in the extracorporeal blood circuit and in the fluid circuit;
a user interface provided with a screen and connected to the one or more sensors;
selecting means for enabling a user to directly set, via the screen, a first safety value and a second safety value, the first
safety value being greater than a reference value of the parameter, the second safety value being less than the reference
value, the reference value being a measured value of the parameter, the selecting means comprising input means for modifying
the first safety value and/or the second safety value, the input means comprising a first button; and

a control unit configured to selectively disable at least part of the selecting means if one of the safety values is reached;
wherein the apparatus is configured such that the first button can be activated a plurality of times in succession and, at
each activation, the first safety value and the second safety value are simultaneously modified by a predetermined quantity
visually on the screen; wherein, when the first button is activated and the first safety value and the second safety value
are simultaneously modified, the first safety value is increased by a predetermined quantity and the second safety value is
decreased by a predetermined quantity; and wherein the input means further comprises a second button, a third button and a
fourth button, wherein, when the second button is activated, the first safety value is decreased by a predetermined quantity
and the second safety value is increased by a predetermined quantity, and wherein, when the third button is activated, the
first safety value is decreased by a predetermined quantity and the second safety value is decreased by a predetermined quantity,
and wherein, when the fourth button is activated, the first safety value is increased by a predetermined quantity and the
second safety value is increased by a predetermined quantity.

US Pat. No. 9,162,020

METHOD AND APPARATUS FOR CONTROLLING AN EXTRA-CORPOREAL BLOOD TREATMENT IN A MEDICAL DEVICE

Gambro Lundia AB, Lund (...

1. Apparatus for controlling an extra-corporeal blood treatment in a medical device, comprising:
a blood treatment device, the blood treatment device being a dialyzer;
an extra-corporeal blood transport line, having at least an arterial line configured to bring blood from a first access of
a patient under treatment to said blood treatment device, a venous line configured to bring blood from said blood treatment
device to a second access of the patient, and at least a first pump for moving blood in said extra-corporeal blood transport
line;

a fluid transport line for a treatment fluid for said blood, the fluid transport line adapted to bring the treatment fluid
from a source to said blood treatment device and from said blood treatment device to an exit, and at least a second pump for
moving the treatment fluid in the fluid transport line;

at least a sensor adapted to provide a measure correlated to at least a treatment parameter of the extra-corporeal blood treatment
or of the treatment device in the medical device;

at least one storage memory; and
at least a control device operatively connected at least with said storage memory and with said sensor;
wherein said control device is configured for:
receiving said measure from said sensor,
correlating said measure at least with referential data of said treatment device for said treatment parameter provided from
said at least one storage memory to obtain a first deviation value (DV1),

comparing said first deviation value (DV1) with a first threshold (T1) to determine when the first deviation value (DV1) is less than or greater than the first threshold (T1),

correlating said measure with patient historical data of said patient under treatment for said treatment parameter during
an extra-corporeal blood treatment of said patient under treatment, provided from said at least one storage memory, to obtain
a second deviation value (DV2),

comparing said second deviation value (DV2) with a second threshold (T2) to determine when the second deviation value (DV2) is less than or greater than the second threshold (T2),

detecting the occurrence of a first event when the first deviation value (DV1) is greater than the first threshold (T1) and the second deviation value (DV2) is less than the second threshold (T2),

detecting the occurrence of a second event when the first deviation value (DV1) is less than the first threshold (T1) and the second deviation value (DV2) is greater than the second threshold (T2),

determining that a first root-cause of the first deviation value (DV1) and the second deviation value (DV2) is related to delivery of the extra-corporeal blood treatment to the patient under treatment when the occurrence of the
first event is detected,

determining that a second root-cause of the first deviation value (DV1) and the second deviation value (DV2) is related to a deviation in a clinical status of the patient under treatment when the occurrence of the second event is
detected.

US Pat. No. 9,156,005

HOLLOW FIBER MEMBRANE AND METHOD FOR MANUFACTURING THEREOF

Gambro Lundia AB, Lund (...

1. A microdialysis device comprising:
a sensor membrane for direct blood applications, the sensor membrane being a semipermeable hollow fiber membrane comprising
an outer wall surface being smooth, continuous, and homogeneous in a nanoscopic scale, an inner wall surface, and an interior
lumen extending along the length of the semipermeable hollow fiber membrane, the semipermeable hollow fiber membrane having
a selective layer on the outer wall surface, the outer wall surface having a smallest pore size and being virtually devoid
of roughness with roughness parameters Ra and Rq of not more than 10 nm, roughness being measured with an atomic force microscope (AFM), and the roughness parameters Ra and Rq being calculated using the following equations:


with N being the total number of data points and Zi being the height of a data point above an average picture level, wherein the semipermeable hollow fiber membrane comprises
a membrane wall having at least four layers with different pore sizes and mass densities, and wherein a layer positioned closest
to a middle of the membrane wall has a smaller pore size and a higher mass density than the two layers directly adjacent on
each side of the layer positioned closest to the middle of the membrane wall.

US Pat. No. 9,527,040

PROCESS FOR CONTINUOUSLY WASHING A HOLLOW FIBER MEMBRANE FOR DEPLETING RESIDUALS

GAMBRO LUNDIA AB, Lund (...

1. A process for removing residuals from hollow fiber membranes by enforced convective transport of a washing fluid through
a membrane wall, said process comprising the step of
bringing the hollow fiber membranes to a bath of the washing fluid prior to mechanically compressing the hollow fiber membranes,
wherein the hollow fiber membranes are rinsed with the washing fluid during mechanical compression, and
wherein the hollow fiber membranes are guided through a pinching device comprising a roller bearing a groove having a width
smaller than the outer diameter of the membranes, and

guiding the hollow fiber membranes over the roller bearing the groove having a width smaller than the outer diameter of the
membranes, the hollow fiber membranes being passed through the groove.

US Pat. No. 9,050,421

FOLLOW-UP OF THE VASCULAR ACCESS OF A DIALYZED PATIENT

Gambro Lundia AB, Lund (...

1. A method of determination of the state of a vascular access of a patient intended to follow successive sessions (i,j) of
extracorporeal blood treatment by extraction and return of the blood via the vascular access, each successive extracorporeal
blood treatment session comprising circulating the blood of the patient, at an extracorporeal blood flow rate, in an extracorporeal
blood circuit having an extracorporeal arterial line, a filter and an extracorporeal venous line, the method comprising the
following steps:
a) determining a value (P1i, P1j, P2i, P2j, . . . ) of at least one hemodynamic extracorporeal parameter (P1, P2 . . . ) of
the patient for at least two sessions (i,j),

b) determining a value (Ei, Ej) of purification effectiveness of the extracorporeal blood treatment for at least two sessions
(i,j), wherein the purification effectiveness is equal or a function of at least one in the group of:

the dialysance (D),
the clearance (C),
the concentration of a substance contained in the blood before the filter (Cbin),
the concentration of a substance contained in the blood after the filter (Cbout) in the extracorporeal circuit,
the dialysis dose (KT/v) under conditions of equal session durations,
c) determining a risk score relating to the state of the vascular access of the patient as a function of at least two values
(Pi, Pj) of the hemodynamic extracorporeal parameter and of at least two determined values (Ei, Ej) of the purification effectiveness.

US Pat. No. 9,366,615

APPARATUS AND PROCESS FOR TESTING FILTERS

GAMBRO LUNDIA AB, Lund (...

1. A process of testing filters in an extracorporeal blood treatment apparatus, the extracorporeal blood treatment apparatus
having an hydraulic circuit comprising:
a supply line configured to connect a source of a fresh treatment fluid to an inlet of a dialysis chamber of a blood treatment
device;

a drainage line configured to connect an outlet of the dialysis chamber to a discharge of a used treatment fluid;
an infusion line;
at least a first filter having a semipermeable membrane which separates a first chamber from a second chamber of said first
filter; and

at least a second filter having a semipermeable membrane which separates a first chamber from a second chamber of said second
filter;

wherein:
a first tract of the supply line is configured to extend in use between the source and an inlet of the first chamber of the
first filter,

a second tract of the supply line is configured to connect an outlet of the second chamber of the first filter to said inlet
the dialysis chamber;

a first tract of the infusion line branches from the second tract of the supply line and is configured to lead to an inlet
of the first chamber of the second filter;

a second tract of the infusion line is configured to connect an outlet of the second chamber of the second filter to an extracorporeal
blood circuit;
the testing process comprising the following steps:
wetting the semipermeable membranes of said first filter and of said second filter;
filling the first chamber of the first filter and the first chamber of the second filter with air while the second chamber
of the first filter and the second chamber of the second filter remain full of liquid;

pressurizing the first chamber of the first filter and the first chamber of the second filter by supplying air to and generating
an overpressure in the first chambers of the first and second filters,

causing a depression in the second chambers of the first and second filters;
measuring the pressure in the first chambers of the first and second filters;
measuring the pressure in the second chambers of the first and second filters;
verifying integrity of the semipermeable membranes of the first and second filters by monitoring the pressure in the first
chambers of the first and second filters and the pressure in the second chambers of the first and second filters.

US Pat. No. 9,138,536

APPARATUS AND A METHOD FOR MONITORING A VASCULAR ACCESS

Gambro Lundia AB, Lund (...

1. An apparatus for monitoring a vascular access, comprising:
a fluid transport system for moving a fluid;
at least one needle connected to the fluid transport system and to a vascular access of an individual, the needle being configured
to supply the fluid to the vascular access, to remove the fluid from the vascular access, or to both supply the fluid to the
vascular access and to remove the fluid from the vascular access;

a perturbation generator configured to generate variations of at least one parameter in the fluid transport system, to generate
variations of at least one parameter in the needle, or to generate variations of at least one parameter in both the fluid
transport system and in the needle;

a sensor configured to be applied directly to the individuals body independent of the needle and the fluid transport system,
wherein the sensor comprises at least an emitter of light radiation and a receiver of light radiation configured to emit a
signal indicating the variations of at least one parameter generated by the perturbation generator and transmitted through
the needle, the emitter of light radiations and the receiver of light radiations configured to be operatively associated to
at least a tissue of the individual's body; and

an analysis device configured to recognize a detachment of the at least one needle, on a basis of said signal.

US Pat. No. 9,095,661

METHOD AND APPARATUS FOR CONTROLLING A FLUID FLOW RATE IN A FLUID TRANSPORT LINE OF A MEDICAL DEVICE

Gambro Lundia AB, Lund (...

1. An apparatus for controlling a fluid flow rate in a fluid transport line of a medical device comprising:
a fluid transport line;
a first pump disposed in said fluid transport line for pumping a fluid;
a chamber disposed in said fluid transport line for collecting said fluid;
a sensor for providing a first value correlated to the amount of fluid in said chamber;
a control device configured for (i) receiving a second value representative of the fluid flow rate through the first pump
(ii) converting the first value into a fluid flow rate value, and (iii) determining if the second value is accurate by comparing
the fluid flow rate value to the second value; and

a second pump disposed in said fluid transport line for pumping the fluid and on a side of the fluid transport line opposite
to said first pump with respect to said chamber.

US Pat. No. 9,364,604

EXTRACORPOREAL BLOOD TREATMENT MACHINE

Gambro Lundia AB, Lund (...

1. A machine for extracorporeal blood treatment, comprising:
at least one blood pump;
at least one housing zone configured for receiving a disposable element comprising at least one extracorporeal blood circuit
in a position wherein the at least one extracorporeal blood circuit is operatively associated with the blood pump;

at least one user interface comprising:
at least one touch screen; and
at least one memory containing at least:
a first data item comprising a first operating instruction, the first operating instruction comprising an alphanumeric indication
describing in word form how to perform a procedural step to prepare the machine for use,

a second data item comprising a second operating instruction, the second operating instruction comprising an alphanumeric
indication describing in word form how to perform a procedural step to prepare the machine for use,

a first image comprising a first pictograph of the machine in a first configuration correlated to said first operating instruction
to illustrate in graphical form how to perform the procedural step to prepare the machine for use provided by said first operating
instruction, said first pictograph comprising a schematic representation of the front of the machine and of the disposable
element to be operatively associated to the machine and visually accentuating at least a first part of said disposable element,

a second image comprising a second pictograph of the machine in a second configuration correlated to said second operating
instruction to illustrate in graphical form how to perform the procedural step to prepare the machine for use provided by
said second operating instruction, said second pictograph comprising a schematic representation of the front of the machine
and of the disposable element to be operatively associated to the machine and visually accentuating at least a second part
of said disposable element different from said first part; and

at least a processor configured to:
display at least one display on a screen of said touch screen, said at least one display including at least a first area and
a second area, said first area being distinct from said second area, said first area exhibiting at least a first touch key
and a second touch key;

display said first data item and said second data item on said first area, said first data item being displayed in a visually-associated
position to said first touch key, said second data item being displayed in a visually-associated position to said second touch
key, said first touch key, second touch key, first data item and second data item being displayed contemporaneously on said
first area;

detect activation of said first touch key and said second touch key; and
display said first image or said second image on said second area, said first image being displayed on said second area when
said first touch key is activated, said second image replacing said first image on said second area such that said second
image is displayed on said second area in place of said first image when said second touch key is activated.

US Pat. No. 9,844,621

SEPARATION MATERIAL

GAMBRO LUNDIA AB, Lund (...

1. A separation material of formula (VI) for selective separation of a blood group A determinant and/or a blood group B determinant
from blood, blood plasma, or a blood product

wherein
saccharide represents a blood group A determinant and/or a blood group B determinant;
R1 represents, independently of one another, straight- chain or branched C1-C10 alkyl, wherein the alkyl group can be unsubstituted, or substituted with at least one substituent, selected from the group
of substituents comprising halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, amidino, hydroxy, thiol, acylamino, alkoxycarbonylamino,
haloalkoxycarbonylamino or alkylsulfonylamino;

Ra represents —H, methyl or ethyl;

K represents —CO—, —NH— or —CH2—;

L represents —CH2—, —NH— or —O—;

Rb represents, independently of one another, straight-chain or branched C1-C10 alkyl such as methyl, ethyl, n- or iso-propyl, n-, iso-, sec- or tert-butyl, n- pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl
or n- decyl, wherein the alkyl group can be unsubstituted, or substituted with at least one suitable substituent, selected
from the group of substituents consisting of halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, amidino, hydroxy, thiol,
acylamino, alkoxycarbonylamino, haloalkoxycarbonylamino or alkylsulfonylamino;

F2 represents —NH—, —CH2—, —C(O)—, —N?, —O—, —CH?, —CH(OH)—or CH2—CH(OH)—;

c and d independently of each other represent 0 or 1;
M1 represents —NH—, —CH2—, —C(O)—, —N?, —O— or —CH?;

R2 represents, independently of one another, straight-chain or branched C1-C10 alkyl, wherein the alkyl group can be unsubstituted, or substituted with at least one suitable substituent, selected from
the group of substituents consisting of halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, hydroxy, thiol, acylamino,
alkoxycarbonylamino, haloalkoxycarbonylamino or alkylsulfonylamino;

R3 represents, independently of each other, —CO—NH—, —NH—CO—, —CO—NH—NH—, —NH—NH—CO—, —CH?N—NH—, —NH—N?CH—, —N?CH—, —CH?N — or
triazolyl,

r represents 0 or an integer from 1-10;
w represents —O—, —S—, —CH2— or —NR?—, wherein R? represents H, or methyl;

x represents an integer from 1-50.
US Pat. No. 9,655,922

DIALYSIS PRECURSOR COMPOSITION

Gambro Lundia AB, Lund (...

12. A method for forming a ready-for-use dialysis solution, the method comprising:
diluting a dialysis acid concentrate solution with a bicarbonate containing concentrate, the dialysis acid concentrate solution
comprising powder components mixed with water, the powder components comprising (1) a sodium chloride powder, (2) at least
one dry acid powder, and (3) an anhydrous calcium chloride powder in a quantity such that a concentration of about 30-125
mM calcium ions is provided in the dialysis acid concentrate solution.

US Pat. No. 9,067,027

FLOW REVERSING DEVICE AND FLUID TREATMENT APPARATUS

Gambro Lundia AB, Lund (...

1. Extracorporeal medical device for reversing flow comprising:
a housing (16) presenting at least four ports (12, 13, 14 and 15) and a lateral wall (21) having an inner surface (22) radially delimiting an internal chamber (17),

a selector body (19) having at least an active portion (20) movable relative to the housing inside the internal chamber, between at least a first position and at least a second position,
in said first position the active portion being positioned relative to the housing so that the first port (12) is in fluid communication with the second port (13) through said internal chamber (17) while the third port (14) is in fluid communication with the fourth port (15) through said internal chamber (17), and in said second position the active portion being positioned relative to the housing so that the first port (12) is in fluid communication with the fourth port (15) through said internal chamber (17) while the second port (13) is in fluid communication with the third port (14) through said chamber, wherein, as a consequence of the displacement of the selector body between the first and second position,
the active portion of the selector body displaces linearly along said inner surface of the lateral wall.

US Pat. No. 9,320,680

MULTICOMPARTMENT CONTAINER

Gambro Lundia AB, Lund (...

1. A flexible multicompartment container configured to contain a medical solution, comprising
a first film sheet;
a second film sheet superimposed on and connected to the first film sheet forming multiple inner side edges;
a first compartment defined by at least a part of at least one of the multiple inner side edges and a first peelable seal
having a first length extension (L1) and a second peelable seal having a second length extension (L2);

a second compartment defined by at least a part of at least one of the multiple inner side edges, the first peelable seal,
and a third peelable seal having a third length extension (L3);

a third compartment defined by at least a part of at least two of the multiple inner side edges, the second, and the third
peelable seal;

the first, the second, and the third peelable seals being joined, and wherein
a first angle (?) extends through the third compartment, is between one of the inner side edges and the third peelable seal,
and is in a range of ten degrees (10°) to eighty degrees (80°);

a second angle (?) extends through the first compartment, is between the first and the second peelable seal, and is in a range
of twenty degrees (20°) to one-hundred thirty degrees (130°);

a third angle (?) extends through the third compartment, is between the second peelable seal and the third peelable seal,
and in a range of one-hundred sixty degrees (160°) to two-hundred degrees (200°), wherein:

L1>L2+L3;

L2>0.05(L2+L3); and

L3>0.05(L2+L3).

US Pat. No. 9,192,709

DISPOSABLE EXTRACORPOREAL BLOOD CIRCUIT AND APPARATUS FOR THE EXTRACORPOREAL TREATMENT OF BLOOD

Gambro Lundia AB, Lund (...

1. A medical apparatus for an extracorporeal fluid treatment comprising:
a main support structure having at least a receiving portion and a holder,
a cassette assembly comprising:
a rigid casing defining at least a first fluid flow chamber, said casing also having an inlet to said first chamber and an
outlet from said first chamber,

a first flexible tube having a first and a second end secured to the rigid casing to form a portion of a loop, the first end
of the first flexible tube being connected to said first chamber outlet,

a second flexible tube having a first end connected to the inlet of said first chamber,
a third flexible tube having a first end secured to the rigid casing and in fluid communication with the second end of said
first tube, characterized in that the cassette assembly further comprises:

a rigid tubular piece having:
a first end connector,
a second end connector, and
an intermediate portion extending between said first and second end connectors for subjecting a fluid flowing through said
intermediate portion to a measurement of at least a fluid parameter, the first end connector of the rigid tubular piece being
secured to one selected in the group comprising: a second end of the second flexible tube, and a second end of the third flexible
tube, the cassette assembly being mounted on the receiving portion carried by the main support structure,

at least a peristaltic pump carried by the main support structure and having a rotor, the portion of the loop of the cassette
assembly receiving the rotor of the peristaltic pump, the holder holding the rigid tubular piece of the cassette assembly,
said holder comprising:

a base carried by the support structure and defining a seat for receiving at least the rigid tubular piece, and
a first sensor and comprising at least an emitter of a signal and a detector which can detect a return signal,
wherein the emitter and the detector are positioned in correspondence of said intermediate portion of the rigid tubular piece,
and wherein the emitter and the detector are positioned according to one of the configurations selected from the group comprising:

a configuration in which a closure element rigidly carries one of said emitter and detector, the base rigidly carrying the
other of said emitter and detector,

a configuration in which a closure element rigidly carries both said emitter and detector, or
a configuration in which the base rigidly carries both said emitter and detector.

US Pat. No. 9,550,019

CAPILLARY DIALYZERS

Gambro Lundia AB, Lund (...

8. A capillary dialyzer comprising:
a) a housing defining a longitudinally extending internal chamber including a first end and a second end;
b) a bundle of semi-permeable hollow fiber membranes disposed within the internal chamber and extending longitudinally from
the first end of the housing to the second end of the housing, the hollow fiber membranes having an outer surface, and a first
end and a second end corresponding to the first end and the second end of the internal chamber;

c) end wall supports for supporting the first and second ends of the hollow fiber membranes within the internal chamber so
as to sealingly separate the first and second ends of the hollow fiber membranes from the outer surface of the hollow fiber
membranes between the first and second ends thereof;

d) a first end cap covering the first end of the housing and a second end cap covering the second end of the housing, the
first and second end caps being applied to the first and second ends of the housing in a fluid-tight manner;

e) an inlet for the introduction of a fluid into the internal chamber and an outlet for the evacuation of a fluid from the
internal chamber at a location between the first and second ends of the housing;

f) support rings disposed between the end wall supports and the housing at the first and second ends of the internal chamber,
each support ring includes a number of ridges distributed circumferentially and defining gaps therebetween; and

g) sealing rings interposed between one of the end wall supports and the first end cap and between another of the end wall
supports and the second end cap, respectively.

US Pat. No. 9,440,018

METHOD FOR ULTRAFILTRATION OF BLOOD

Gambro Lundia AB, Lund (...

1. A method for filtering blood comprising:
withdrawing blood from an adult patient;
performing ultrafiltration by filtering the withdrawn blood in a filter having an active filter membrane surface of no greater
than 0.2 meters squared (m2) to remove ultrafiltrate from the blood, wherein the filter membrane blocks the passage of blood molecules having a molecular
weight of at least 60,000 Daltons, wherein an amount of the removed ultrafiltrate is an effective therapeutic amount for treating
a fluid overload condition of the patient;

infusing the ultrafiltrated blood into the adult patient, and
pumping the ultrafiltrate from the filter a rate no greater than one liter per hour.

US Pat. No. 9,365,316

CONTAINER WITH SUB-CHAMBERS SEPARATED BY PEELABLE SEAL

Gambro Lundia AB, Lund (...

1. A container comprising:
a first side wall and a second side wall, the first and second side walls permanently joined by first and second opposing
seam sides, and a third seam side extending between the first and second seam sides, such that a chamber is formed between
the side walls;

a first protrusion having a first curved portion and extending from the first seam side into the chamber;
a second protrusion having a second curved portion and extending from the third seam side into the chamber; and
a peelable seal separating the chamber into a first sub-chamber capable of receiving a first liquid content and a second sub-chamber
capable of receiving a second liquid content, thereby allowing, if the peelable seal is opened, a liquid content of the first
sub-chamber to be mixed with a liquid content of the second sub-chamber, wherein the peelable seal overlaps and intersects
the first and second curved portions of the first and second protrusions, respectively, and wherein at least one of the first
protrusion and the second protrusion is loop-shaped.

US Pat. No. 9,289,544

METHOD AND DEVICE FOR DETECTING A CONFIGURATION OF WITHDRAWAL AND RETURN DEVICES

Gambro Lundia AB, Lund (...

1. A device for detecting a reversed configuration of withdrawal and return devices coupling an extracorporeal blood flow
circuit to a cardiovascular system of a subject, wherein the withdrawal and return devices are configurable in a normal configuration
and the reversed configuration, wherein in the normal configuration the withdrawal device is in an upstream position of said
cardiovascular system for withdrawal of fluid and the return device is in a downstream position of the cardiovascular system
for return of fluid, and further wherein in the reversed configuration the positioning of the return and withdrawal devices
is reversed, the device comprising:
a primary pressure sensor in the extracorporeal blood flow circuit, the primary pressure sensor configured to provide a primary
measurement signal comprising at least a subject pulse from a subject pulse generator in the cardiovascular system;

a signal processor configured to:
receive the primary measurement signal obtained by the primary pressure sensor in the extracorporeal blood flow circuit;
process the primary measurement signal for extraction of primary pressure data originating from the subject pulse generator
in the cardiovascular system, the primary pressure data comprising at least a part of the subject pulse from the subject pulse
generator;

calculate a parameter value from the primary pressure data; and
determine the reversed configuration based at least partly on the parameter value calculated from the primary pressure data
comprising at least a part of the subject pulse from the subject pulse generator; and

a notification apparatus to provide a notification when the reversed configuration has been determined.

US Pat. No. 9,233,197

HEAT EXCHANGER AND METHOD FOR HEAT EXCHANGING

Gambro Lundia AB, Lund (...

1. A plate heat exchanger associated with a first fluid circuit including a passage for a primary fluid and a second fluid
circuit including a passage for a first secondary fluid, wherein the second fluid circuit is separate from the first fluid
circuit, the plate heat exchanger comprising:
a stack of fluid plates;
a plurality of membranes, wherein each membrane is sandwiched between a pair of fluid plates in the stack of fluid plates;
a plurality of interspaces, wherein each interspace is formed between one of the membranes and one of the pair of fluid plates,
and the one of the membranes is adjacent the one of the pair of fluid plates;

wherein the passage of the first fluid circuit extends through a first pair of the fluid plates, a first membrane and a first
interspace, and

wherein the passage for the first secondary fluid extends through the first pair of the fluid plates, the first membrane and
a second interspace;

wherein at least one of the passages of the first or second fluid circuits extends along at least a majority of a length of
the plate heat exchanger, and

a third fluid circuit separate from the first fluid circuit and the second fluid circuit, where a passage of the third fluid
circuit for a second secondary fluid extends through a second pair of the fluid plates in the stack of fluid plates, a second
membrane of the membranes and through a third interspace formed between the second membrane and one of the fluid plates of
the second pair of fluid plates.

US Pat. No. 9,117,012

MEDICAL APPARATUS

Gambro Lundia AB, Lund (...

1. A medical apparatus comprising at least a medical machine for fluid treatment comprising:
means for treating a fluid;
a control unit configured at least for sending command signals and for receiving information from the means for treating a
fluid;

a device for entering data to be supplied to the control unit for enabling a user to generate the command signals for the
means for treating a fluid;

a display for viewing at least a part of the information received from the control unit relating to the means for treating
a fluid, the display of the medical machine visualizing a graphic user interface which shows at least a part of the information
received by the control unit of the means for treating a fluid;

a web server operatively cooperating with the control unit, the web server being configured to publish a predetermined number
of web pages, at least one of which reproduces the graphic user interface shown on the display of the medical machine, the
web pages further publishing a plurality of further data relating to the medical machine, the web pages being remotely accessible
via connecting means and being consultable via a web browser, wherein the medical machine further exhibits remote access and
control means which operatively cooperate with the control unit such that the remote access and control means are able to
control one or more functions of the medical machine during fluid treatment, the remote access and control means being configured
for enabling reproduction of the web server of the graphic user interface shown on the display in the web pages, and

wherein the reproduction of the graphic user interface is updated at each predetermined variation of at least a parameter
represented in the graphic user interface, wherein the graphic user interface is subdivided into a plurality of regions and
the reproduction of each respective region is only updated at each predetermined variation of the parameter shown in the region,
without updating regions in which the predetermined variation has not occurred.

US Pat. No. 9,345,827

OBTAINING CONTROL SETTINGS FOR A DIALYSIS MACHINE

Gambro Lundia AB, Lund (...

1. A dialysis system comprising:
a dialysis machine configured to perform treatment sessions of renal replacement therapy, and
a logic device for generating control settings of machine-related parameters of the dialysis machine,
wherein the dialysis machine is configured to obtain from the logic device, prior to each treatment session for an individual
patient, a set of current control settings of the machine -related parameters to be applied in the treatment session, and
wherein the logic device is configured to:

obtain a set of therapeutic targets comprising a target value of one or more physiological parameters for the patient, wherein
the target value represents part of a desired status of the patient after the treatment session, and wherein the set of therapeutic
targets includes a target value of (i) a measure of a property of the patient's blood including at least one of urea concentration,
an electrolyte concentration, and an acid-base balance and (ii) a measure of a fluid balance of the patient;

obtain status data that represents a current status of the patient prior to the treatment session; and
compute, as a function of the set of therapeutic targets and the status data, the set of current control settings of the machine-related
parameters, wherein the logic device is configured to compute at least part of the current control settings based on a predictive
model that estimates the physiological response of the patient to the machine-related parameters during the treatment session,
such that the set of current control settings of the machine-related parameters enable the dialysis machine to achieve said
target value of one or more physiological parameters including the target value of (i) a measure of a property of the patient's
blood including at least one of a urea concentration, an electrolyte concentration, and an acid-base balance and (ii) a measure
of a fluid balance of the patient at the end of the treatment session.

US Pat. No. 9,314,480

DIALYSIS PRECURSOR COMPOSITION

Gambro Lundia AB, Lund (...

1. A dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing
with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution, wherein said dialysis acid precursor
composition consists of powder components comprising sodium chloride, at least one dry acid and at least one magnesium salt,
said at least one magnesium salt is present as magnesium chloride 4.5-hydrate (MgCl2.4.5H2O) and wherein said dialysis acid
precursor composition is sealed in a moisture-resistant container with a water vapor transmission rate less than 0.2 g/m2/d
at 38° C./90% RH.

US Pat. No. 9,144,639

DIALYSIS APPARATUS AND METHOD FOR CONTROLLING A DIALYSIS APPARATUS

Gambro Lundia AB, Lund (...

1. A dialysis apparatus comprising:
a blood treatment unit comprising a dialysate chamber and a blood chamber separated by a semipermeable membrane;
a dialysate circuit comprising a supply line and a discharge line connected to said blood treatment unit, respectively, upstream
and downstream of said dialysate chamber;

a preparation device configured to prepare a dialysate containing a substance which is also present in blood, the preparation
device includes a regulator configured to regulate a concentration of the substance in dialysate, said preparation device
being connected to said supply line;

a blood circuit configured to circulate extracorporeal blood through said blood chamber;
a controller configured to determine a value representative of the concentration of said substance in the blood and configured
to drive the regulator as a function of the determined value representative of the substance concentration in the blood,

wherein the controller causes the preparation device to regulate the concentration of the substance in the dialysate to tend
towards at least one of:

(i) the determined concentration of the substance in the blood if the determined concentration of the substance in the blood
is greater than a minimum threshold, and

(ii) the minimum threshold if the determined concentration of the substance in the blood is less than the minimum threshold,
and

wherein the controller causes the preparation device to regulate the concentration of the substance in the dialysate to tend
towards at least one of:

(iii) the determined concentration of the substance in the blood if the determined concentration of the substance in the blood
is less than a maximum threshold, and

(iv) the maximum threshold if the determined concentration of the substance in the blood is greater than the maximum threshold.

US Pat. No. 9,610,393

APPARATUS AND METHOD FOR THE TREATMENT OF BLOOD WITH SELECTIVE EXTRACTION OF SOLUTES

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising:
at least a main treatment unit comprising a first compartment and a second compartment separated by a semipermeable membrane,
a blood withdrawal line for blood to be treated connected to an inlet of the first compartment of the main treatment unit,
a blood return line connected to an outlet of the first compartment of the main treatment unit, wherein the blood return line,
the blood withdrawal line and the first compartment are part of an extracorporeal blood circuit,

at least an auxiliary treatment unit comprising at least one fluid inlet and at least one fluid outlet, wherein the auxiliary
treatment unit comprises a semipermeable membrane dividing said auxiliary treatment unit into a first chamber and a second
chamber, the at least one fluid inlet communicating with the first chamber and the at least one fluid outlet communicating
with the second chamber, wherein at least a portion of fluid entering the first chamber passes through the semipermeable membrane
into the second chamber and exits the second chamber through the at least one fluid outlet,

a first fluid line having a first end connected to an outlet of the second compartment of the main treatment unit and a second
end connected to the fluid inlet of the auxiliary treatment unit,

a second fluid line having a first end connected to the fluid outlet of the auxiliary treatment unit and a second end connected
to said extracorporeal blood circuit,

a fluid flow regulator on at least one of said first and second fluid lines,
at least one sensor for determining a parameter related to a pressure drop across said auxiliary treatment unit and emitting
a corresponding pressure signal, wherein said pressure drop represents a transmembrane pressure across said semipermeable
membrane of the auxiliary treatment unit, and

a control unit configured to execute a control procedure for a treatment time for a single patient that comprises:
receiving said pressure signal from the sensor and determining a corresponding parameter value, and
controlling the flow regulator at least based on said parameter value and to keep said value of the pressure drop across said
auxiliary treatment unit substantially constant throughout the treatment time,

wherein the molecular permeability of the membrane of the main treatment unit is greater than the molecular permeability of
the membrane of the auxiliary treatment unit,

wherein the difference in cut-off value between the membrane of the main treatment unit and the membrane of the auxiliary
treatment unit lies between about 10,000 Daltons and about 30,000 Daltons.

US Pat. No. 10,052,423

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND PROCESS OF CALCULATING SET FLOW RATES IN A MEDICAL APPARATUS FOR DELIVERY OR COLLECTION OF FLUIDS

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal treatment of blood comprising:a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;
a blood withdrawal line connected to an inlet of the primary chamber, and a blood return line connected to an outlet of the primary chamber said blood lines being configured for connection to a patient cardiovascular system;
a blood pump configured to control the flow of blood through the blood lines;
an effluent fluid line connected to an outlet of the secondary chamber;
at least two further fluid lines selected in the group comprising:
a pre-dilution infusion fluid line connected at one end thereof to the blood withdrawal line,
a post-dilution infusion fluid line connected at one end thereof to the blood return line,
a dialysis fluid line connected at one end thereof to the inlet of the secondary chamber,
a pre-blood pump infusion fluid line connected at one end thereof to the blood withdrawal line in a region positioned in use upstream the blood pump,
at least one solution pump configured to regulate the flow of fluid through said fluid lines; and
a control unit comprising a memory and connected operably to the at least one solution pump, the control unit being configured to:
enter a set value by an operator for at least a first fluid flow rate selected in the group including:
a fluid flow rate (Qrep1) through the pre-dilution infusion fluid line,
a fluid flow rate (Qrep2) through the post-dilution infusion fluid line,
a fluid flow rate (Qpbp) through the pre-blood pump infusion fluid line,
a fluid flow rate (Qdial) through the dialysis fluid line, and
a fluid removal rate (Qpfr) from the patient,
enter a set value by the operator for a prescribed dose (Dset) to be delivered,
calculate set values of at least a second and a third of the fluid flow rates of said group of flow rates by applying said prescribed dose value (Dset) and the set value of the first fluid flow rate to a plurality of mathematical relations, wherein said plurality of mathematical relations stored in said memory comprise one or more of the following:
a convection-diffusion relation, relating the total fluid flow rate through said infusion fluid lines (Qrep1+Qrep2+Qpbp) with the fluid flow rate through said dialysis fluid line (Qdial), or
a pre-post relation, relating the fluid flow rates (Qrep1+Qpbp) through pre-dilution infusion fluid line and pre-blood pump infusion fluid line with the fluid flow rate through the post-dilution infusion fluid line (Qrep2), and
wherein calculating the set values of the at least second and third of the fluid flow rates reduces a number of flow rate set values entered into the control unit by the operator.

US Pat. No. 9,446,181

METHOD TO TREAT BLOOD BY CONTROLLING BLOOD PUMPS WITH FLUID PUMPS

Gambro Lundia AB, Lund (...

1. A method of treating blood in a blood treatment apparatus including:
a blood treatment unit configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used
blood treatment fluid, the blood being passed on a blood side of a semi-permeable membrane and the blood treatment fluid being
passed on a fluid side of said semi-permeable membrane in the unit; at least one fluid pump configured to pass blood treatment
fluid through the blood treatment unit; and at least one blood pump configured to extract untreated blood from a blood source,
pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel, the method comprising:

pumping blood by the at least one blood pump while driving the at least one blood pump with blood treatment fluid pumped by
the at least one fluid pump,

during a first period, the pumping by the at least one blood pump extracts the untreated blood from the blood source and during
a second period the treated blood is pumped by the at least one blood pump into the target vessel, and

controlling a trans-membrane flow between the blood side and the fluid side of the blood treatment unit through the semi-permeable
membrane.

US Pat. No. 9,289,545

CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment, comprising:
an extracorporeal blood circuit and a connection system configured to connect the extracorporeal blood circuit to the vascular
system of a patient, the extracorporeal blood circuit comprising:

a blood processing device;
at least first and second energy transfer sensors, the first energy transfer sensor associated with an arterial-side of the
extracorporeal blood circuit, and the second energy transfer sensor associated with a venous-side of the extracorporeal blood
circuit;

at least one pumping device; and
a control system configured to switch between a pre-treatment mode and a blood treatment mode, the control system configured
in the blood treatment mode to operate said at least one pumping device to pump blood from the vascular system via the connection
system through the blood processing device and back to the vascular system via the connection system, said control system
comprising:

an energy transfer sensor signal input device to obtain measurement data from said at least first and second energy transfer
sensors configured to sense a transfer of energy comprising at least one pressure wave between the patient and the connection
system or between the patient and the extracorporeal blood circuit, wherein the measurement data comprises first and second
measurement signals from said first and second energy transfer sensors in the extracorporeal blood circuit; and

a signal processor connected to the energy transfer sensor signal input device and being configured to, in the pre-treatment
mode and post-priming prior to blood treatment, process the measurement data to detect connection of the extracorporeal blood
circuit to the arterial-side and venous-side of the vascular system of the patient,

wherein the connection is configured to be detected by said control system identifying a characteristic change in the measurement
data indicating the connection of the extracorporeal blood circuit to the vascular system of the patient, and, upon such identification
of the characteristic change, the control system is configured to take a dedicated action to control operation of the apparatus,
the dedicated action comprising signaling the apparatus for entering into the blood treatment mode by operating said at least
one pumping device only upon identification of the characteristic change in the first measurement signal and the second measurement
signal.

US Pat. No. 9,138,380

PREPARATION OF MEDICAL SOLUTIONS FROM POWDERY MATERIAL

Gambro Lundia AB, Lund (...

1. A package for storing powdery material which is to be mixed with a solvent to form a medical solution, said package comprising:
a compartment which is at least partially defined by two opposing wall portions and contains the powdery material in the form
of at least two distinct sets of powdery material of different compositions, wherein the opposing wall portions are brought
into engagement with the powdery material so as to immobilize the sets of powdery material, and the at least two distinct
sets of powdery material are separated from each other by a constriction region, in which the wall portions are brought into
close proximity with each other without being fixedly attached to each other; and

a connector configured to selectively admit a fluid into the package, wherein the admitted fluid expands the compartment and
mixes the sets of the powdery material with the solvent in the expanded compartment.

US Pat. No. 9,750,865

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A CONTROL METHOD THEREFOR

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment comprising:
at least a treatment unit having at least a first chamber and at least a second chamber separated from one another by a semipermeable
membrane;

at least a blood removal line connected to an inlet port of a first chamber and predisposed to remove blood from a patient;
at least a blood return line connected to an outlet port from the first chamber and predisposed to return treated blood to
the patient;

at least an expansion chamber placed at least in one of the blood removal line and the blood return line, the expansion chamber
being arranged in use to contain a predetermined quantity of gas in an upper portion and a predetermined quantity of blood
at a predetermined level in a lower portion, the blood removal line, the blood return line, the first chamber and the at least
an expansion chamber being part of an extracorporeal blood circuit;

at least a blood pump operating at the extracorporeal blood circuit such as to move the blood in the circuit;
at least a pressure sensor associated to the expansion chamber and configured such as to enable determining pressure values
internally of the expansion chamber;

at least a fluid evacuation line connected to an outlet port of the second chamber;
a control unit connected to the at least a pressure sensor, with the pump, and configured to:
move the blood pump such as to generate a variable blood flow comprising a constant flow component of a desired blood flow
value and a variable flow component having a substantially nil mean value, the variable blood flow generating at least in
the expansion chamber a pressure progression that is variable in time comprising a pressure component oscillating about a
mean value;

receive from the at least a sensor a plurality of pressure values for a time period comprising a plurality of pressure oscillations
about the means value, the pressure values being measured at successive time instants;

calculate, as a function of the pressure values, a control value that is representative of the oscillating pressure component,
compare the control value representing the oscillating pressure component with a reference threshold, and
determine, following the comparison, the occurrence or not of a condition of variation of the blood level in the expansion
chamber.

US Pat. No. 9,632,018

METHOD AND DEVICE FOR MONITORING THE INTEGRITY OF A CONNECTION SYSTEM

Gambro Lundia AB, Lund (...

1. A method comprising:
providing a connection system between a first fluid containing system and a second fluid containing system, a first pulse
generator comprising a pump in the first fluid containing system configured to generate first pulses formed by a plurality
of frequency components, and at least one pressure sensor in the first fluid containing system configured to detect the plurality
of frequency components from the first pulse generator;

generating measurement data from the at least one pressure sensor configured to detect second pulses from a second pulse generator
in the second fluid containing system when the connection system is intact;

generating a time-dependent monitoring signal based on the measurement data that retains multiple frequency components of
the plurality of frequency components and contains a sequence of apparent pulses, said apparent pulses representing a superposition
of the second pulses on the first pulses when the connection system is intact;

calculating a superposition disturbance parameter value based on a pulse feature representing at least one of a magnitude
feature, a timing feature, and a shape feature of at least one of the apparent pulses in the monitoring signal retaining the
multiple frequency components, the superposition disturbance parameter value representing a disturbance caused by the superposition
of the second pulses on the first pulses when the connection system is intact;

determining the integrity of the connection system based at least partly on the calculated superposition disturbance parameter
value; and

performing, in response to determining that the integrity of the connection system has been compromised, at least one of:
issuing an alarm to a user to take appropriate action, stopping the pump in the first fluid containing system, and activating
a clamping device on the first fluid containing system.

US Pat. No. 9,582,164

DIALYSIS APPARATUS WITH VERSATILE USER INTERFACE AND METHOD AND COMPUTER PROGRAM THEREFOR

Gambro Lundia AB, Lund (...

1. An apparatus for performing a plurality of operation steps of a dialysis process, said apparatus comprising:
a process controller for controlling the apparatus to perform the operation steps of the dialysis process, monitor process
progress of the dialysis process and monitor sensor inputs of sensors of the apparatus; and

a user interface comprising a display, an input device and a user interface controller, wherein the user interface controller
is connected to enable presentation of graphical data on the display, and wherein the user interface controller is connected
to enable user interaction with the graphical data and connected to exchange information with the process controller, wherein
the exchanged information is based on the user interaction of the user interface and monitoring of process progress of the
dialysis process and sensor inputs of sensors of the apparatus monitored by the process controller, and wherein

each of the operation steps are classified in the user interface controller as one of a sequential operation step, which is
dependent on completion of another operation step, and a non-sequential operation step, which is independent of completion
of another operation step,

the user interface controller is configured to represent each of the operation steps by an operation step item which is a
graphical item suitable to be presented on said display, and

the user interface controller is further configured to dynamically, for each of the operation steps, control enabling and
disabling of selection among the corresponding operation step items based on a state of the respective operation step, wherein
a completed state is assigned to each operation step that is completed, a non-completed state is assigned to each operation
step that is non-completed, a selectable state is assigned to each operation step item of an operation step that is non-sequential
and each operation step item of an operation step that is sequential but only in relation to a completed operation step, and
a non-selectable state is assigned to each operation step item of an operation step that is sequential in relation to a non-completed
operation step.

US Pat. No. 9,616,161

DIALYSIS PRECURSOR COMPOSITION

Gambro Lundia AB, Lund (...

1. A dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing
with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution, the dialysis acid precursor composition
consisting of:
powder components comprising a sodium chloride powder, at least one dry acid powder and at least one calcium chloride powder,
wherein the calcium chloride is present as an anhydrous component in the dialysis acid precursor composition, and the calcium
chloride is in a quantity such that a concentration of 30-125 mM calcium ions is provided in the dialysis acid concentrate
solution.

US Pat. No. 9,533,087

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment, comprising:
at least one treatment unit having at least one first chamber and at least one second chamber which are separated from one
another by a semipermeable membrane;

at least one blood removal line connected with an inlet port of the first chamber and configured to remove blood from a patient;
at least one blood return line connected to an outlet port of the first chamber and configured to return treated blood to
the patient;

at least one infusion line of a replacement fluid, the at least one infusion line connected to one of said blood removal line
and blood return line;

at least one fluid evacuation line connected to an outlet port of the second chamber in order to receive at least one fluid
that has been filtered across the semipermeable membrane;

a regulating device of a transmembrane pressure between the first chamber and the second chamber of the treatment unit, the
regulating device being active on at least one of the lines; and

a control unit connected with the regulating device and configured such as to perform a setting sequence of the transmembrane
pressure, the setting sequence comprising:

commanding the regulating device by setting a first increase (?TMP1) at a first value of the transmembrane pressure (TMP1) in order to reach a second transmembrane pressure (TMP2);

determining a value of a control parameter (?1) corresponding to the first increase in transmembrane pressure;

comparing the value of the control parameter (?1) with a reference value (?ref) and, if the value of the control parameter is greater than the reference value, commanding the regulating device by imposing
a second increase (?TMP2) on the transmembrane pressure which is greater than the first increase (?TMP1) in order to reach a third value of the transmembrane pressure (TMP3);

wherein after reaching the third value of the transmembrane pressure (TMP3), the setting sequence further comprises:

determining a value of a control parameter (?n) corresponding to an nth transmembrane pressure increase;

comparing the value of the control parameter (?n) with a reference value (?ref(n)) and, if the value of the control parameter (?n) is greater than the reference value (?ref(n)), determining an (n+1)th increase (?TMPn+1) of an entity which is greater than the entity of the nth increase (?TMPn); and

commanding the regulating device to impose the (n+1)th increase (?TMPn+1) on the transmembrane pressure.

US Pat. No. 9,427,513

DETECTING BLOOD PATH DISRUPTION IN EXTRACORPREAL BLOOD PROCESSING

Gambro Lundia AB, Lund (...

1. A monitoring device for monitoring a blood path extending from a blood vessel access of a human subject through an extracorporeal
blood processing apparatus and back to the blood vessel access, wherein the blood path comprises a blood withdrawal device
and a blood return device for connection to the blood vessel access, and a pumping device operable to pump blood through the
blood path from the blood withdrawal device to the blood return device, said monitoring device comprising:
an input for obtaining pressure data from a pressure sensor arranged upstream of the pumping device in the blood path to detect
pressure pulses in the blood pumped through the blood path; and

a signal processor connected to said input and being configured to:
generate, based on the pressure data, a time-dependent monitoring signal comprising cross-talk pulses that originate from
one or more pulse generators in the extracorporeal blood processing apparatus and have propagated in a direction downstream
of the pumping device through the blood return device, the blood vessel access and the blood withdrawal device to the pressure
sensor,

process the monitoring signal for calculation of a parameter value that indicates a presence or absence of the cross-talk
pulses, and

detect, based at least partly on the parameter value, a disruption of the blood path downstream of the pumping device.

US Pat. No. 9,776,143

LOW CUT-OFF ULTRAFILTRATION MEMBRANES

GAMBRO LUNDIA AB, Lund (...

1. A porous hollow fiber ultrafiltration membrane comprising at least one of a polysulfone, a polyethersulfone and a polyarylethersulfone,
and polyvinylpyrrolidone and having a sieving coefficient for inulin with an average molecular weight of 5.2 kDa in aqueous
solution of less than 0.25 and a hydraulic permeability of water at 37° C. in the range of from 1 to 15×10?4 cm3/cm2×s×bar.

US Pat. No. 9,514,322

BLOOD TREATMENT SYSTEM, MACHINE, AND METHOD WITH USER INTERFACE BLOCKING AND UNBLOCKING

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment machine comprising one or more sensors for monitoring a blood treatment device and a
user interface for regulating interaction of a user with the blood treatment device according to a predetermined procedure,
the predetermined procedure defined by a sequence of one or more critical actions each comprising one or more procedural steps,
which user interface comprises at least one screen, at least one memory comprising at least three images, at least a controller,
and one or more keys displayable on the at least one screen, wherein the one or more sensors do not detect activation of the
one or more keys, wherein the one or more critical actions do not include the user activating the one or more keys, wherein
at least one of the one or more sensors is associated with at least one of the one or more critical actions, wherein the one
or more critical actions comprise at least one machine critical action being actuated, performed, and completed by the blood
treatment device and at least one user critical action being actuated, performed, and completed by the user, and further wherein
the controller is programmed to:
detect activation of a user critical action key of the one or more keys displayed on the at least one screen, wherein the
user critical action key is associated with one of the user critical actions;

display on the screen a first image which in the memory is assigned to the activated user critical action key;
block the user interface in response to detected activation of the user critical action key until a first signal is received,
wherein the first signal is a sensor signal from a sensor of the one or more sensors associated with the one user critical
action indicative of the completion of the one user critical action, and further wherein blocking the user interface comprises
restricting selectable alternatives of the user interface such that selection through the user interface by the user cannot
interfere with completion of the one user critical action;

upon receipt of the first signal, unblock the user interface and display on the screen a second image and a machine critical
action key associated with one of the machine critical actions occurring later in the predetermined procedure than the one
user critical action;

detect activation of the machine critical action key displayed on the at least one screen;
block the user interface in response to detected activation of the machine critical action key until a second signal is received,
wherein the second signal is a sensor signal from a sensor of the one or more sensors associated with the one machine critical
action indicative of the completion of the one machine critical action, and further wherein blocking the user interface comprises
restricting selectable alternatives of the user interface such that selection through the user interface by the user cannot
interfere with completion of the one machine critical action; and

upon receipt of the second signal, unblock the user interface and display on the screen a third image, wherein the third image
corresponds to one or more of the procedural steps occurring later in the predetermined procedure than the one machine critical
action.

US Pat. No. 9,687,507

DIALYSIS PRECURSOR COMPOSITION

Gambro Lundia AB, Lund (...

1. A dialysis acid precursor composition for use in preparation of a dialysis acid concentrate solution and for mixing with
water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution, the
dialysis acid precursor composition comprising:
powder components comprising glucose, at least one dry acid and at least one magnesium salt, wherein the glucose is present
as an anhydrous component in the dialysis acid precursor composition, wherein the at least one magnesium salt is present as
magnesium chloride 4.5-hydrate (MgCl2·4.5H2O), and wherein the dialysis acid composition is sealed in a container not allowing passage of an amount of moisture equal
to or above a difference in crystalline water between magnesium chloride hexahydrate and magnesium chloride 4.5-hydrate (MgCl2·4.5H2O).

US Pat. No. 9,442,036

METHODS AND DEVICES FOR MONITORING THE INTEGRITY OF A FLUID CONNECTION

Gambro Lundia AB, Lund (...

1. A method for monitoring the integrity of a fluid connection between first and second fluid containing systems based on
at least one time-dependent measurement signal from at least one pressure sensor in the first fluid containing system, wherein
the first fluid containing system is an extracorporeal blood flow circuit comprising an arterial access device, a blood processing
device, a venous access device and a first pulse generator, and the second fluid containing system is a human blood system
comprising a blood vessel access and a second pulse generator, wherein:
the arterial access device is for connecting to the human blood system,
the venous access device is connected to the blood vessel access to form the fluid connection,
the first pulse generator is a pumping device arranged in the extracorporeal blood flow circuit to pump blood from the arterial
access device through the blood processing device to the venous access device, and

the at least one pressure sensor is arranged to detect first pulses originating from the first pulse generator and second
pulses originating from the second pulse generator, said method comprising:

receiving, at a processor, said at least one time-dependent measurement signal from the at least one pressure sensor;
generating, by the processor, a time-dependent monitoring signal based on said at least one-time dependent measurement signal
in which the first pulses are eliminated, said generating including (i) filtering said at least one time dependent measurement
signal to remove the first pulses, (ii) deriving, based on timing information indicative of the timing of the second pulses
in said at least one time-dependent measurement signal, a set of signal segments in the at least one time-dependent measurement
signal after filtering the at least one time-dependent measurement signal to remove the first pulses, and (iii) aligning and
adding the signal segments, based on the timing information, to generate said monitoring signal;

calculating, by the processor, a parameter value based on signal values within a time window in the time-dependent monitoring
signal, the parameter value representing a distribution of the signal values; and

determining, by the processor, the integrity of the fluid connection based at least partly on the parameter value.

US Pat. No. 9,433,356

DEVICES, A COMPUTER PROGRAM PRODUCT AND A METHOD FOR DATA EXTRACTION

Gambro Lundia AB, Lund (...

1. A device for monitoring the integrity of a fluid connection between an extracorporeal fluid system and a vascular system
of a subject having a natural breathing system, said system comprising:
a mechanical pulse generator configured to generate a first pulse;
a pressure sensor configured to sense the first pulse and a second pulse originating from the natural breathing system, and
output a measurement signal;

a signal processor; and
a memory device storing a plurality of instructions, which when executed by the signal processor, cause the signal processor
to:

(i) analyze the measurement signal to isolate the first pulse and the second pulse;
(ii) monitor whether the second pulse remains present in the measurement signal, and
(iii) when the second pulse originating from the natural breathing system is not present in the measurement signal, send a
signal causing at least one of: (a) an alarm device to activate an alarm, (b) a blood pump to stop, or (c) a valve to close.

US Pat. No. 9,612,182

METHOD AND DEVICE FOR DETECTING A FAULT CONDITION

Gambro Lundia AB, Lund (...

1. A method for detecting and responding to a fault condition in a pumping device included in an extracorporeal blood treatment
system, said method comprising:
obtaining measurement data by detecting pulses in the extracorporeal blood treatment system using at least one pressure sensor
arranged in the extracorporeal blood treatment system, wherein the pulses comprises first pulses originating from the pumping
device of the extracorporeal blood treatment system and second pulses originating from a physiological pumping device in a
subject connected to the extracorporeal blood treatment system;

generating a time-dependent monitoring signal based on the measurement data obtained from the at least one pressure sensor,
wherein the monitoring signal comprises one or more of the first pulses and none of the second pulses;

processing the monitoring signal to calculate a parameter value which is indicative of the shape of at least part of a first
pulse in the monitoring signal;

evaluating the parameter value for detection of a fault condition in the pumping device; and
activate an alarm and/or stop the pumping device if a fault condition is detected.

US Pat. No. 9,974,895

PERMSELECTIVE MEMBRANE FOR TREATING VASCULAR CALCIFICATIONS IN CHRONIC HEMODIALYSIS PATIENTS

GAMBRO LUNDIA AB, Lund (...

1. A method of treating vascular calcification in a hemodialysis patient, comprising withdrawing and bypassing the blood from the patient in a continuous flow into contact with one face of a hemodialysis membrane, simultaneously passing dialysate solution in a continuous flow on an opposite face of the hemodialysis membrane to the side of the hemodialysis membrane in contact with the blood, the flow of the dialysate solution being countercurrent to the direction of flow of blood, and returning the blood into the patient, wherein the hemodialysis membrane comprises at least one hydrophobic polymer and at least one hydrophilic polymer and has a Molecular Weight Rejection Onset (MWRO) of between 15 and 20 kD and a Molecular Weight Cut-Off (MWCO) of between 170-320 kD as determined by dextran sieving before blood contact of the membrane.

US Pat. No. 9,931,456

APPARATUS AND METHOD TO CHECK EXTRACORPOREAL CIRCUIT

Gambro Lundia AB, Lund (...

1. An extracorporeal treatment apparatus configured to receive an extracorporeal circuit, the treatment apparatus comprising:a pump configured to pump a liquid through a passage in the extracorporeal circuit while the circuit is mounted to the treatment apparatus;
a flow coupling connectable to an outlet of the passage, wherein a flow impedance at the flow coupling is a constant or known value, and wherein the flow impedance at the flow coupling is due to a flow restriction having a smaller cross-sectional flow area for the liquid than any portion of the liquid passage extending from the pump to the flow coupling; and
a controller which is configured to:
store a flow resistance value at the flow coupling, said flow resistance value being either a value set by the operator before starting the apparatus or a pre-stored constant value known by the controller before starting the apparatus;
control the pump at a speed corresponding to a set fluid flow value to move liquid through the passage and the flow coupling;
collect actual data indicative of a pressure condition of the liquid flowing through the passage and flow coupling during control of the pump at said speed;
store circuit type data uniquely corresponding to an expected circuit type mounted to the treatment apparatus out of a plurality extracorporeal circuit types that may be mounted to the treatment apparatus;
retrieve a sectional dimension of the mounted circuit type based on said circuit type data uniquely corresponding to the mounted circuit type;
determine expected data indicative of an expected pressure value of the liquid flowing through the passage and flow coupling as a function of the set fluid flow value or pump speed and of the sectional dimension of the mounted circuit type and as a function of said flow resistance value;
compare the expected data with the actual data; and
determine as a function of the comparing step whether the expected circuit type
corresponds to the circuit type actually mounted on the apparatus.

US Pat. No. 9,585,992

APPARATUS AND METHOD FOR DETERMINING A PARAMETER INDICATIVE OF THE PROGRESS OF AN EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal treatment of blood comprising:
a preparation line having one end configured for being connected to an inlet of a secondary chamber of a treatment unit having
a primary chamber and said secondary chamber separated by a semi-permeable membrane;

a spent dialysate line having one end configured for being connected to an outlet of said secondary chamber;
a control unit configured for commanding execution of the following steps:
causing a treatment liquid to flow in the preparation line to the secondary chamber, the treatment liquid having a characteristic
which is one selected in the group of:

conductivity of the treatment liquid,
concentration of at least one substance in the treatment liquid;
receiving at least one prescription value for the characteristic;
causing a plurality of consecutive and continuously repeated variations of the characteristic around the prescription value
in the liquid flowing in the preparation line, each one of said variations being obtained by:

changing the value of the characteristic in the preparation line until a first inlet value of the characteristic is reached,
said first value being different from the prescription value,

keeping the characteristic in the preparation line unchanged at said first inlet value during a first time interval,
changing the value of the characteristic in the preparation line until a second inlet value of the characteristic is reached,
wherein the second inlet value is different than the prescription value and the prescription value is comprised between said
first and said second inlet values,

keeping the characteristic in the preparation line unchanged at said second inlet value during a second time interval following
the first time interval,

during each of said variations the characteristic in the liquid flowing in the preparation line taking the first inlet value
during the first time interval and taking the second inlet value during the second time interval;

for of each of said variations:
receiving measures of a first and second outlet values respectively adopted by the characteristic in the spent dialysate line
in response to the first and second inlet values taken by the same characteristic in the preparation line, and

computing at least one value of a parameter indicative of the effectiveness of the extracorporeal blood treatment from said
first and second outlet values taken by the characteristic in the spent dialysate line.

US Pat. No. 9,463,202

DIALYSIS PRECURSOR COMPOSITION

Gambro Lundia AB, Lund (...

1. A dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing
with water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution,
wherein said dialysis acid precursor composition consist of powder components comprising glucose, at least one dry acid and
at least one magnesium salt, wherein said glucose is present as an anhydrous component in said dialysis acid precursor composition,
wherein said at least one magnesium salt is present as magnesium chloride 4.5-hydrate (MgCl2·4.5H2O) and wherein said dialysis acid precursor composition is sealed in a moisture-resistant container with a water vapor transmission
rate less than 0.2 g/m2/d at 38° C./90% RH.

US Pat. No. 9,243,991

DEVICE AND PROCESS FOR TESTING HOLLOW FIBRE MEMBRANE FILTERS

Gambro Lundia AB, Lund (...

1. A process for testing a filter comprising two compartments separated by a porous membrane which is a bundle of hollow fiber
membranes, comprising
i) providing a filter having a dry porous membrane which is a bundle of hollow fiber membranes;
ii) establishing a pressure gradient between the compartments;
iii) introducing a volume of testing liquid which is sufficient to substantially reduce gas permeability of the porous membrane
but is less than or equal to the total pore volume of the porous membrane into the compartment having the higher pressure
and permitting the testing liquid to wet the porous membrane;

iv) monitoring the pressure gradient between the compartments or measuring gas flow through the membrane.

US Pat. No. 9,186,450

METHOD AND APPARATUS FOR PRIMING AN EXTRACORPOREAL BLOOD CIRCUIT

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising:
a casing internally defining a containing space;
a treatment fluid circuit which is arranged internally of the containing space, the treatment fluid circuit comprising:
a fresh treatment fluid supply line which is configured to connect a treatment fluid source with a fluid chamber of a blood
treatment device of a type having a semipermeable membrane; and

a used treatment fluid discharge line which is configured to connect the fluid chamber with a drain;
a waste priming fluid discharge apparatus comprising:
a first priming fluid discharge port which comprises a respective first opening obtained on said casing;
a first priming fluid discharge line which connects the first priming fluid discharge port with the used treatment fluid discharge
line, the first priming fluid discharge line having at least a first tract thereof arranged internally of the containing space,
wherein the first priming fluid discharge line includes a first check valve which is configured to block flow towards the
first priming fluid discharge port;

a second priming fluid discharge port which comprises a respective second opening obtained on said casing; and
a second priming fluid discharge line which connects the second priming fluid discharge port with the used treatment fluid
waste line, the second priming fluid discharge line having at least a second tract arranged internally of the containing space,
the second tract being distinct from the first tract, wherein the second priming fluid discharge line includes a second check
valve which is configured to block flow towards the second priming fluid discharge port; and

the apparatus being further configured to hold an extracorporeal blood circuit comprising:
a blood chamber of said blood treatment device in which the semipermeable membrane separates the blood chamber from the fluid
chamber;

an arterial blood line having a first arterial end connected to the blood chamber and a second arterial end;
a venous blood line having a first venous end connected to the blood chamber and a second venous end;
wherein the first priming fluid discharge port is configured to removably receive one of said second arterial end and said
second venous end, and wherein the second priming fluid discharge port is configured to removably receive the other of said
second arterial end and said second venous end.

US Pat. No. 9,572,920

DISPOSABLES FOR BLOOD TREATMENT, AND METHODS OF OPERATING THE SAME

Gambro Lundia AB, Lund (...

1. An apparatus for blood treatment, the apparatus comprising:
a supply system of a treatment fluid; and
a disposable for use in blood treatment, the disposable comprising a blood treatment unit for connection to the supply system
that is operable to pump the treatment fluid through the blood treatment unit during the blood treatment, a blood withdrawal
connector which is connected to the blood treatment unit via a blood withdrawal line, and a blood return connector which is
connected to the blood treatment unit via a blood return line,

wherein one of the blood withdrawal and blood return lines comprises a membrane pump arrangement operable to pump blood through
the blood treatment unit, wherein the membrane pump arrangement comprises first and second blood line branches that are connected
at an upstream end and at a downstream end, wherein a first membrane pump is arranged in the first blood line branch, and
a second membrane pump is arranged in the second blood line branch,

wherein each of the first and second membrane pumps comprises a pumping chamber and a flexible member separating the pumping
chamber into a blood compartment and a working fluid compartment and being movable within the pumping chamber so as to vary
the volume relationship between the blood compartment and the working fluid compartment, wherein the blood compartment is
arranged for fluid communication with the upstream and downstream ends, and the working fluid compartment is arranged for
fluid communication with the supply system, and wherein each of the first and second membrane pumps comprises an upstream
valve and a downstream valve for controlling blood flow between the blood compartment and the upstream end and the downstream
end, respectively, and

wherein the disposable is configurable for operation in a first blood access mode, in which the blood withdrawal and blood
return connectors are connected to a single access device, and the membrane pump arrangement is operable to alternately draw
blood from the upstream end, and to pump blood through the downstream end, thereby generating a pulsatile flow of blood through
the blood treatment unit, and in a second blood access mode, in which the blood withdrawal and blood return connectors are
connected to a first and a second access device, respectively, and the membrane pump arrangement is operable to concurrently
draw blood from the upstream end and pump blood through the downstream end, thereby generating an essentially continuous flow
of blood through the blood treatment unit, wherein the membrane pump arrangement is configured for connection to the supply
system such that alternating flows of treatment fluid generated by the supply system and supplied to the first and second
membrane pumps causes the membrane pump arrangement to generate the pulsatile flow of blood in the first mode and the essentially
continuous flow of blood in the second mode, and

wherein one of the upstream or downstream valves is controllable to selectively open for blood flow by application of positive
pressure to the treatment fluid, and (b) the other of the upstream or downstream valves is controllable to selectively block
blood flow by application of positive pressure to the treatment fluid.

US Pat. No. 9,943,636

APPARATUS FOR DETERMINING A PARAMETER INDICATIVE OF THE PROGRESS OF AN EXTRACORPOREAL BLOOD TREATMENT

GAMBRO LUNDIA AB, Lund (...

1. An apparatus for extracorporeal treatment of blood comprising:a preparation line having one end connected to an inlet of a secondary chamber of a treatment unit and configured to convey fresh treatment liquid to the secondary chamber, the fresh treatment liquid presenting a characteristic (Cdin) which is one selected from the group of:
conductivity in the fresh treatment liquid, and
concentration of at least one substance in the fresh treatment liquid;
a spent dialysate line having one end connected to an outlet of said secondary chamber and configured to remove spent liquid from the secondary chamber, the spent liquid presenting a characteristic (Cdout) which is one selected from the group of:
conductivity in the spent liquid, and
concentration of at least one substance in the spent liquid; and
a control unit configured for commanding execution of a task for determination of a parameter indicative of the effectiveness of the extracorporeal blood treatment, said task comprising the following steps:
receiving at least one prescription baseline (Cdset) for the characteristic (Cdin) in the fresh treatment liquid;
causing fresh treatment liquid to flow in the preparation line to the secondary chamber with the characteristic being at said prescription baseline (Cdset);
causing spent liquid to flow out of the secondary chamber into the spent dialysate line;
receiving at least one parametric mathematical model which puts into relation the characteristic (Cdin) in the fresh treatment liquid with the characteristic (Cdout) in the spent liquid, said parametric mathematical model presenting a prefixed number of free parameters;
causing an upstream variation of the value of the characteristic (Cdin) in the fresh treatment liquid with respect to said prescription baseline (Cdset) thereby causing a corresponding and timely delayed downstream variation of the same characteristic (Cdout) in the spent liquid flowing in the spent dialysate line;
measuring a plurality of values taken by a reference portion of said downstream variation of the characteristic (Cdout) in the spent liquid, said reference portion having duration shorter than the entire duration of the downstream variation;
estimating said free parameters of the at least one parametric mathematical model by means of said reference portion measured values and identifying one single characteristic mathematical model which puts into relation the characteristic (Cdin) in the fresh treatment liquid with the characteristic (Cdout) in the spent liquid; and
computing at least one value of a parameter indicative of the effectiveness of the extracorporeal blood treatment by using said characteristic mathematical model and one or more values taken by the characteristic (Cdin) in the fresh treatment liquid.

US Pat. No. 9,610,394

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment, comprising:
a blood removal line having an end configured to be connected to a cardiovascular system of a subject;
at least a blood treatment unit comprising a semipermeable membrane which divides the unit itself into a first and a second
chamber, the first chamber being connected to a second end of the blood removal line;

a blood return line, configured to return treated blood to the patient, the blood return line having a first end connected
to the first chamber of the blood treatment unit and a second end configured to be connected to the cardiovascular system
of the patient;

at least a first pump operating on the blood removal line;
at least a second pump operating at the blood return line to the patient;
a discharge line connected to the second chamber of the treatment unit for receiving waste from the unit;
at least a first blood reservoir operating on the blood return line upstream of the second blood pump;
at least a sensor configured to detect at least a parameter selected from among a group consisting of:
a pressure in the first reservoir,
a blood level present in the first reservoir,
a blood volume present in the first reservoir, and
a pressure in a tract of the return line upstream the second blood pump,and configured to emit a signal corresponding to a measured value of the parameter;
a control unit connected to the first pump, to the second pump and to the sensor, wherein the control unit is configured to
operate in a first operating mode, corresponding to a single-access configuration of the extracorporeal circuit, and in a
second operating mode, corresponding to a double-access configuration of the extracorporeal circuit, the control unit, in
the second operating mode, being configured to carry out following steps:

receiving the signal emitted by the sensor,
controlling the first pump to promote the removal of blood from the patient along the blood removal line;
controlling the second pump to promote return of the blood to the patient along the return line, the control of the second
pump being carried out on the basis of the signal emitted by the sensor.

US Pat. No. 10,022,481

CAPILLARY DIALYZERS

GAMBRO LUNDIA AB, Lund (...

1. A capillary dialyzer comprising a housing and a bundle of semi-permeable hollow fiber membranes disposed therein, characterized in that the bundle of hollow fiber membranes comprises from 85 to 95% crimped fibers and from 5 to 15% non-crimped fibers, relative to the total number of fibers in the bundle.

US Pat. No. 9,623,165

CASSETTE FOR PUMPING A TREATMENT SOLUTION THROUGH A DIALYZER

Gambro Lundia AB, Lund (...

1. A cassette for pumping a treatment solution through a dialyzer in a dialysis system, said cassette comprising:
a body,
a hydraulic manifold which is defined inside the body and configured for fluid communication with a first hydraulic connector
on the body, the first hydraulic connector being arranged for connecting the dialyzer to the cassette,

a pneumatic manifold which is defined inside the body and configured for fluid communication with a first pneumatic connector
on the body, the first pneumatic connector being arranged for connecting the cassette to a pneumatic pressure source,

a set of solution pumps including an upstream solution pump and a downstream solution pump, each solution pump of the set
of solution pumps including a pump cavity which is defined inside the body for fluid communication with the hydraulic and
pneumatic manifolds,

a calibration cavity connected for fluid communication with a bypass line that extends between the upstream and downstream
solution pumps, and

a valve arrangement which is operable to selectively communicate the pump cavity with the hydraulic and pneumatic manifolds
so as to, during the operation of the respective solution pump, reciprocate an interface in the pump cavity and thereby displace
the treatment solution through the hydraulic manifold,

wherein each of the pump cavities defines, during operation of the respective solution pump, said interface as a direct gas-to-liquid
interface in the pump cavity between a gaseous substance admitted via the pneumatic manifold and the treatment solution admitted
via the hydraulic manifold, and

wherein the cassette is operable in a calibration phase, in which the valve arrangement is operable to cause one of the upstream
or downstream solution pumps to perform an emptying stroke that moves the direct gas-to-liquid interface from an upper reference
level to a lower reference level so as to push the treatment solution into the bypass line, cause the other of the upstream
or downstream solution pumps to perform a filling stroke that moves the direct gas-to-liquid interface from a lower reference
level to an upper reference level so as to draw the treatment solution from the bypass line, and selectively establish fluid
communication between the bypass line and the calibration cavity during the emptying and filling strokes so as to transfer
a known or measurable calibration volume between the calibration cavity and the pump cavity of the upstream solution pump
or the downstream solution pump, wherein a level detector is operable to measure a level change corresponding to the calibration
volume in said pump cavity of the upstream solution pump or the downstream solution pump.

US Pat. No. 9,808,567

DIAPHRAGM REPOSITIONING FOR PRESSURE POD USING POSITION SENSING

Gambro Lundia AB, Lund (...

1. An extracorporeal treatment system including a pressure measurement system comprising:
a pressure pod body comprising at least a pod body portion and a base body portion;
a diaphragm separating a liquid side cavity defined at least in part by the pod body portion from a transducer side cavity
defined at least in part by the base body portion, wherein the liquid side cavity is in fluid communication with an inlet
and an outlet, and further wherein the diaphragm is displaceable from a centered measuring position into the liquid side cavity
towards the pod body portion and is displaceable from the centered measuring position into the transducer side cavity towards
the base body portion;

a pressure transducer operatively coupled to the transducer side cavity such that pressure of liquid when present in the liquid
side cavity is transferred to the transducer side cavity via the diaphragm and measureable by the pressure transducer;

a position sensor to sense the position of the diaphragm;
a controller operatively coupled to the position sensor to receive one or more signals representative of the position of the
diaphragm and to generate a control signal based thereon for use in repositioning the diaphragm towards the centered measuring
position; and

pump apparatus operatively coupled to the controller and the transducer side cavity to reposition the diaphragm to the centered
measuring position based on the control signal generated by the controller.

US Pat. No. 10,052,425

RESERVOIR STATUS LIGHTS INDICATING STATUS OF CORRESPONDING RESERVOIRS FOR EXTRACORPOREAL BLOOD TREATMENT APPARATUS

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising:a housing comprising a front face and a bottom end;
one or more pumps located on or in the housing, wherein the one or more pumps are configured to move blood and a treatment solution during extracorporeal blood treatment, wherein the one or more pumps are located above the bottom end of the housing;
a plurality of reservoir scales positioned proximate the bottom end of the housing, wherein each reservoir scale of the plurality of reservoir scales is configured to weigh a reservoir operably attached to the reservoir scale, wherein the reservoir is positioned below the bottom end of the housing, and wherein the plurality of reservoir scales comprises at least a first reservoir scale and a second reservoir scale;
a plurality of reservoir status lights, wherein each reservoir status light of the plurality of reservoir status lights is associated with one reservoir scale of the plurality of reservoir scales, and wherein the plurality of reservoir status lights comprises a first reservoir status light associated with the first reservoir scale and a second reservoir status light associated with the second reservoir scale, and further wherein the first reservoir status light emits light from a location that is closer to the first reservoir scale than the second reservoir scale;
a control unit operably attached to the one or more pumps, the plurality of reservoir scales, and the plurality of reservoir status lights, wherein the control unit is configured to:
receive a weight signal from each reservoir scale of the plurality of reservoir scales, wherein the weight signal from each reservoir scale is indicative of a weight of a reservoir operably attached to the reservoir scale;
make a determination that a reservoir operably attached to the first reservoir scale has passed a first selected weight limit at least partially based on the weight signal received from the first reservoir scale;
change a mode of light emitted by the first reservoir status light after making the determination that the first reservoir scale has passed the first selected weight limit;
make a determination that a reservoir operably attached to the second reservoir scale has passed a second selected weight limit at least partially based on the weight signal received from the second reservoir scale;
change a mode of light emitted by the second reservoir status light after making the determination that the second reservoir scale has passed the second selected weight limit;
make a determination that the weight of liquid in the reservoir operably attached to the first reservoir scale has not passed the first selected weight limit;
cause the first reservoir status light to emit light of a first color when the weight of liquid in the reservoir operably attached to the first reservoir scale has not passed the first selected weight limit;
make a determination that the weight of liquid in the reservoir operably attached to the second reservoir scale has not passed the second selected weight limit;
cause the second reservoir status light to emit light of a second color when the weight of liquid in the reservoir operably attached to the second reservoir scale has not passed the second selected weight limit, wherein the first color and the second color are different colors.

US Pat. No. 9,486,570

MULTIPART FLUID SYSTEM AND A SYSTEM FOR REGIONAL CITRATE ANTICOAGULATION IN AN EXTRACORPOREAL BLOOD CIRCUIT

Gambro Lundia AB, Lund (...

1. A multipart fluid system for treating extracorporeal blood comprising:
an extracorporeal blood passage including an inlet configured to receive blood withdrawn from a patient and an outlet configured
to discharge treated blood to be infused into the patient;

a pump configured to be coupled to the extracorporeal blood passage to simultaneously withdraw blood from the patient, pass
withdrawn blood through the blood passage and infuse treated blood into the patient;

a first fluid source configured to be in fluid communication with the extracorporeal blood passage, wherein the first fluid
source contains an anticoagulation fluid including at least 8 mM citrate, and

a second fluid source configured to be in fluid communication with the extracorporeal blood passage, wherein the second fluid
source contains a blood treatment fluid comprising 2-8mM citrate and 1 to 5 mM total calcium.

US Pat. No. 9,724,298

METHOD TO FORM A DIALYSIS COMPOSITION COMPRISING CITRATE, CALCIUM AND MAGNESIUM

Gambro Lundia AB, Lund (...

1. A method to form a dialysis composition, the method comprising:
determining for a patient a prescribed calcium concentration for a dialysis fluid to be administered to the patient, wherein
the determination is made based on a non-citrate containing calcium dialysis fluid;

introducing 0.5 to 3 mM citrate to the dialysis fluid,
introducing 1 to 5 mM total calcium to the dialysis fluid, wherein the total calcium results in a calcium concentration that
is 0.1 to 0.2 mM per 1 mM citrate greater than the prescribed calcium concentration; and

introducing 0 to 1.5 mM total magnesium to the dialysis fluid.

US Pat. No. 9,095,664

METHOD AND SYSTEM FOR PROVIDING PRIMING AND RESTITUTION LIQUIDS FOR AN EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. A method for an extracorporeal blood treatment system including: (i) a pumping console having a source of a replacement
fluid, a first pump, a blood pump and a collection vessel (ii) a blood circuit including an access line, a blood chamber of
a blood treatment device having a semipermeable membrane separating the blood chamber from an effluent chamber of the blood
treatment device, a return line, and a source line from the source (iii) and a dialysis circuit including a dialysate line
the effluent chamber of the blood treatment device, and an effluent line, the method comprising the steps of:
coupling the blood circuit to the console including mounting the access line onto the blood pump and mounting the source line
to the first pump;

connecting the access line to the source of the replacement fluid and connecting an outlet of the return line to a collection
vessel;

priming the blood circuit by pumping with the first pump the replacement fluid from the source into the access line to fill
the blood circuit with the replacement fluid, wherein the collection vessel receives the replacement fluid from the blood
circuit; and

priming the dialysis circuit by pumping the replacement fluid through the effluent line, the effluent chamber of the blood
treatment device, the dialysate line and the return line, to the collection vessel.

US Pat. No. 9,636,447

FILTERING OF A TIME-DEPENDENT PRESSURE SIGNAL

Gambro Lundia AB, Lund (...

1. A device for processing a time-dependent pressure signal obtained from a pressure sensor in a fluid containing system associated
with a first pulse generator and a second pulse generator, wherein the pressure sensor is arranged in the fluid containing
system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse
generator, wherein the first pulse generator operates in a sequence of pulse cycles, each pulse cycle resulting in at least
one first pulse, said device comprising:
an input for the pressure signal; and
a signal processor connected to said input and configured to:
repetitively obtain a current data sample within a current pulse cycle in the pressure signal;
calculate, for each current data sample within the current pulse cycle, a reference value as a function of a cycle-synchronized
data sample in one or more other pulse cycles in the pressure signal, the cycle-synchronized data sample being obtained to
have a location in said one or more other pulse cycles that corresponds to a location of the current data sample in the current
pulse cycle; and

operate a subtraction algorithm on the current data sample, using said reference value obtained for the current data sample
as input, so as to generate a current output sample which is essentially free of a signal component attributable to said at
least one first pulse.

US Pat. No. 9,770,546

APPARATUS AND METHOD OF CONTROLLING AN EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment comprising:
at least a treatment unit having at least a first chamber and at least a second chamber separated from one another by a semipermeable
membrane;

at least a blood removal line connected to an inlet port of the first chamber and predisposed to remove blood from a patient;
at least a blood return line connected to an outlet port from the first chamber and predisposed to return treated blood to
the patient;

at least an expansion chamber placed at least in one of the blood removal line and the blood return line, the expansion chamber
being arranged in use to contain a predetermined quantity of gas in an upper portion and a predetermined quantity of blood
at a predetermined level in a lower portion thereof, the blood removal line, the blood return line, the first chamber and
the at least an expansion chamber being part of an extracorporeal blood circuit;

at least a blood pump operating at the extracorporeal blood circuit such as to move the blood in the circuit;
at least a pressure sensor associated to the expansion chamber and configured to enable determining pressure values internally
of the expansion chamber;

at least a fluid evacuation line connected to an outlet port of the second chamber; and
a control unit connected to the at least a pressure sensor, with the pump, and configured to:
move the blood pump to generate a variable blood flow comprising a constant flow component equal to a desired value of blood
flow and a variable flow component oscillating about the constant component and having a substantially nil average value,
the variable blood flow component generating, at least in the expansion chamber, a pressure progression that is variable over
time comprising a pressure component oscillating about an average value;

receive from the at least a pressure sensor a plurality of measured pressure values for a time period comprising a plurality
of oscillations of the pressure about the average value, the pressure values being measured in successive time instants;

calculate, as a function of the pressure values, an average value of the pressure;
acquire an estimated volume variation value in the expansion chamber linked to the variable flow component;
calculate, as a function of the pressure values, an estimated pressure variation in the expansion chamber representing the
oscillating pressure component; and

determine a representative magnitude of a blood level in the expansion chamber as a function of the average value of the pressure,
the estimated volume variation value and the value of the estimated pressure variation in the expansion chamber.

US Pat. No. 10,124,107

CLEANING OF BIOLOGICAL FLUID

Gambro Lundia AB, Lund (...

1. A method of removing a deleterious substance bound to a protein in an extracorporeal biological fluid comprising:a) introducing a displacer substance into the biological fluid under conditions in which the displacer substance displaces deleterious substance bound to the protein, thereby resulting in additional unbound deleterious substances in the biological fluid; and
b) removing unbound deleterious substance from the biological fluid,
wherein the displacer substance is a combination of sodium octanoate with one or both of sodium salicylate and sodium acetylsalicylate.

US Pat. No. 9,636,445

AMBULATORY ULTRAFILTRATION DEVICE WITH CONTROL UNIT PROGRAMMED TO CONTROL A DRIVE FLUID PUMP TO PERFORM ULTRAFILTRATION

Gambro Lundia AB, Lund (...

28. An ambulatory ultrafiltration device for connection to the vascular system of a subject, comprising:
a blood filter having a blood side configured for fluid communication with the vascular system of the subject, an ultrafiltrate
side, and a semipermeable membrane disposed between the blood side and the ultrafiltrate side;

a membrane chamber having a blood side and a drive fluid side separated by a flexible membrane, wherein the blood side of
the membrane chamber is in fluid communication with the blood side of the blood filter; and

a drive fluid pump in fluid communication with the drive fluid side of the membrane chamber, wherein the drive fluid pump
is operable to pump a liquid drive fluid out of and into the drive fluid side of the membrane chamber to cause the blood side
of the membrane chamber to alternate between a withdrawal phase and a return phase, wherein the withdrawal phase comprises
blood being withdrawn along a blood path in fluid communication with the subject and the blood filter to the blood side of
the membrane chamber, and the return phase comprises blood being returned from the blood side of the membrane chamber to the
subject along said blood path;

a control unit programmed to control the drive fluid pump to perform ultrafiltration, such that the blood filter separates
ultrafiltrate from the blood during at least one of the withdrawal and return phases.

US Pat. No. 9,895,478

HEMODIALYSIS ON-LINE PORT LEAK DETECTION

Gambro Lundia AB, Lund (...

1. An apparatus comprising:
a blood pump configured to move blood through a blood circuit;
an on-line port extending away from a housing of the apparatus and a liquid line coupled to the on-line port and in fluid
communication with the blood circuit;

a leak detector fixed to and extending from the housing of the apparatus, the leak detector comprising a collector defining
a containment volume and a liquid sensor at least partially located within the containment volume, wherein the collector is
located adjacent and below the on-line port and configured to collect liquid leaking from the on-line port, wherein the liquid
sensor is configured to sense a liquid in the containment volume; and

a control unit operably connected to the liquid sensor, wherein the control unit is configured to:
receive a signal from the liquid sensor, and
determine that the liquid is leaking from the on-line port based on the signal received from the liquid sensor.

US Pat. No. 9,782,530

PACKAGING OF POWDERY MATERIAL FOR PREPARATION OF A MEDICAL SOLUTION

Gambro Lundia AB, Lund (...

20. A method of manufacturing a package for storing powdery material which is to be mixed with a solvent to form a medical
solution, said method comprising:
providing a package blank that defines an interior space between two overlapping sheets of flexible material;
disposing the powdery material at a first end of the interior space while leaving a non-filled portion that extends from the
powdery material to an opposite second end of the interior space;

sealing the interior space of the package blank to form a sealed cavity comprising the non-filled portion and a filled cavity
portion containing the powdery material, the filled cavity portion located at the first end and including two sub-cavities
located side by side from the first end towards the second end and separated by a line in the two overlapping sheets, the
non-filled portion extending from the filled cavity portion towards the second end; and

sweeping a portion of the package blank, including the non-filled portion of the sealed cavity, around the filled cavity portion,
so as to form a roll-up package.

US Pat. No. 9,802,162

LEAK TESTING OF A PRESSURE VESSEL

Gambro Lundia AB, Lund (...

1. In combination, an end cap and a housing having an open end, the end cap to close the open end of the housing, one of the
end cap and housing comprising a slot and the other of the end cap and housing comprising a key, the key and slot together
forming a key and slot joint when the end cap and housing are assembled, n first recesses, n an integer, the n first recesses
arranged with an angular spacing of about 360°/n to each other around the slot of the end cap, and n second recesses arranged
with an angular spacing of about 360°/n to each other around the slot, each second recess being arranged adjacent, but offset
perimetrally of the housing and end cap from a respective first recess to provide a respective fluid passage which extends
at least partially perimetrally of the housing and end cap between an inside and an outside of the assembled end cap and housing,
wherein n is an integer greater than 1.
US Pat. No. 9,821,102

DIALYSIS PRECURSOR COMPOSITION

Gambro Lundia AB, Lund (...

1. A dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing
with water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution,
the dialysis acid precursor composition consisting of:
powder components comprising a glucose powder, at least one dry acid powder, a calcium chloride powder, and a hydrated magnesium
chloride powder selected from the group consisting of a magnesium chloride hexahydrate powder and a magnesium chloride dihydrate
powder, wherein the glucose powder and the calcium chloride powder are present as anhydrous components in the dialysis acid
precursor composition, wherein the calcium chloride is in a quantity such that a concentration of 30-500 mM calcium ions is
provided in the dialysis acid concentrate solution, and wherein the dialysis acid precursor composition is sealed in a moisture-resistant
container with a water vapour transmission rate less than 0.3 g/m2/d at 38° C./90% RH.

US Pat. No. 9,931,452

TREATMENT SOLUTION DELIVERY IN AN EXTRACORPOREAL BLOOD TREATMENT APPARATUS

Gambro Lundia AB, Lund (...

1. A blood treatment apparatus comprising:a blood circuit that includes an arterial line intended to draw blood from a patient and a venous line intended to return blood to the patient;
a filter having a primary chamber and a secondary chamber separated by a semi-permeable membrane, wherein the blood circuit is configured to pass blood through the primary chamber, and wherein the blood treatment apparatus comprises a drain line exiting the secondary chamber to remove spent dialysate from the secondary chamber, and
a treatment solution delivery system having a treatment solution port and configured to deliver treatment solution to the secondary chamber and/or to the blood circuit through the treatment solution port, wherein the treatment solution delivery system comprises:
a first intermediate container;
a first gravimetric scale configured to weigh the first intermediate container;
a second intermediate container;
a second gravimetric scale configured to weigh the second intermediate container;
a source flow controller configured to deliver treatment solution from a treatment solution source to the first intermediate container weighed by the first gravimetric scale and to the second intermediate container weighed by the second gravimetric scale;
a sterilizing filter located between the treatment solution source and the treatment solution port such that treatment solution delivered to the treatment solution port from the treatment solution source passes through the sterilizing filter, wherein the sterilizing filter is located downstream from the source flow controller;
an output controller configured to control the flow of treatment solution from the first intermediate container and the second intermediate container to the treatment solution port;
a container selection controller located in a treatment solution path between the source flow controller and the output controller;
a control unit operably attached to the first gravimetric scale, the second gravimetric scale, the source flow controller, the container selection controller, and the output controller, wherein the control unit is configured to:
receive weight signals from the first and second gravimetric scales;
control the source flow controller, the container selection controller, and the output controller in a first mode in which treatment solution is delivered to the output controller while treatment solution leaves the first intermediate container and the second intermediate container fills with treatment solution, wherein treatment solution can flow into the second intermediate container from the source flow controller while treatment solution is prevented from flowing into the first intermediate container and treatment solution can flow from the first intermediate container to the output controller while treatment solution is prevented from flowing out of the second intermediate container;
control the source flow controller, the container selection controller, and the output controller in a second mode in which the second intermediate container delivers treatment solution to the output controller while the first intermediate container fills with treatment solution from the treatment solution source, wherein treatment solution can flow into the first intermediate container from the source flow controller while treatment solution is prevented from flowing into the second intermediate container and treatment solution can flow from the second intermediate container to the output controller while treatment solution is prevented from flowing out of the first intermediate container.

US Pat. No. 10,052,427

FILTER DEVICE COMBINING BEADS AND FIBERS

GAMBRO LUNDIA AB, Lund (...

1. A hollow fiber membrane module for the treatment of fluids, comprising(a) a cylindrical filter housing;
(b) a bundle of essentially parallel hollow fiber membranes distributed longitudinally within the cylindrical filter housing, wherein the hollow fiber membranes comprise open ends that are in fluid communication with a distribution space and with a collection space, and wherein the open ends are embedded in a sealing compound such that the open ends of the hollow fibers extend through the sealing compound;
(c) a filtrate space, which is closed off from the distribution space and the collection space and a lumen space of the hollow fiber membranes;
(d) an inlet means for feeding the fluid into one of the filtrate space and the distribution space which is in fluid communication with the lumen side of the hollow fiber membranes, the filtrate space being optionally interconnected with one of the inlet means and an outlet means;
(e) a first outlet means for removing the treated fluid from the cylindrical filter housing, said first outlet means being in fluid communication with the collection space, and optionally a second outlet means for removing treated fluid from the filtrate space;
wherein a fiber allocation in the cylindrical filter housing is between 15% to 70%; and
wherein the filtrate space is homogenously populated with a particulate material being capable of interacting with at least one component of the fluid with a filling ratio of between 0.6 and 1.0, wherein the filling ratio is the volume in ml of the maximal amount of particulate material which can be accommodated in the filtrate space of a given hollow fiber membrane module (VPM) and the utilizable volume in ml of the filtrate space of said module (VFS):

wherein VPM resents the volume of the particulate material which can be accommodated in the filtrate space of the module, and VFS represents the utilizable filtrate space, and wherein VPM is calculated from
wherein mPM represents the amount of particulate material which can be accommodated in the filtrate space of the module and p represents the tapping density of the particulate material according to DIN ISO 3953.

US Pat. No. 9,902,939

DEVICE FOR RENAL CELL EXPANSION

Gambro Lundia AB, Lund (...

1. A method of culturing adherent renal cells comprising providing a membrane comprising a copolymer of acrylonitrile and
sodium methallylsulfonate, and further comprising polyethyleneimine, and heparin, and inoculating the membrane with adherent
renal cells.

US Pat. No. 9,833,556

CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment, comprising:
an extracorporeal blood circuit and a connection system configured to connect the extracorporeal blood circuit to a vascular
system of a patient, the extracorporeal blood circuit comprising:

a blood processing device; and
at least one pumping device;
at least one energy transfer sensor comprising at least a first energy transfer sensor and a second energy transfer sensor,
the first energy transfer sensor associated with an arterial-side of the extracorporeal blood circuit and the second energy
transfer sensor associated with a venous-side of the extracorporeal blood circuit; and

a control system configured to switch between a pre-treatment mode and a blood treatment mode, the control system configured
in the blood treatment mode to operate the at least one pumping device to pump blood from the vascular system via the connection
system through the blood processing device and back to the vascular system via the connection system, the control system comprising:

an energy transfer sensor signal input device to obtain measurement data from at least the first energy transfer sensor and
the second energy transfer sensor configured to sense a transfer of energy between the patient and the connection system or
between the patient and the extracorporeal blood circuit, wherein the measurement data comprises a first measurement signal
from the first energy transfer sensor and a second measurement signal from the second energy transfer sensor; and

a signal processor connected to the energy transfer sensor signal input device and being configured to, during post-priming
prior to blood treatment, process the measurement data to detect connection of the extracorporeal blood circuit to at least
one of an arterial-side and a venous-side of the vascular system of the patient, wherein the connection is configured to be
detected by said control system identifying a characteristic change in the measurement data indicating the connection of the
extracorporeal blood circuit to at least one of the arterial-side and the venous-side of the vascular system of the patient,
and, upon such identification of the characteristic change, the control system is configured to take a dedicated action to
control operation of the apparatus, wherein the dedicated action comprises activating at least part of a patient protection
system which is configured to identify fault conditions in at least one of the extracorporeal blood circuit, the connection
system and the patient upon identification of the characteristic change in at least one of the first measurement signal and
the second measurement signal.

US Pat. No. 9,791,270

METHOD AND SYSTEM FOR DETECTING OR VERIFYING A BLOOD CIRCUIT CONNECTED TO AN EXTRACORPOREAL BLOOD TREATMENT CONSOLE

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment console comprising:
at least one pump connectable to an extracorporeal blood circuit including a blood passage having a first section connectable
to a patient, a second section coupled to the pump, wherein the second section includes a chamber having a gas filled portion,
a third section connected to the patient and a sensor for sensing a parameter data of the extracorporeal blood circuit, and

a controller being configured to perform the following steps:
a. controlling the pump to pump a liquid into the first section of the blood passage;
b. closing the third section or issuing a prompt to close the third section, after the liquid has been pumped into the blood
passage;

c. receiving a first parameter data from the sensor, said first parameter data being chosen in a group comprising a pressure
data from a pressure sensor, a fluid level data from a level sensor, a volume data from a capacitive sensor, a shut-off device
connected to the third blood section remaining closed, while the pump is stopped;

d. determining either a first pressure value based on the first parameter data or a first level value based on the first parameter
data or a first volume value based on the first parameter data, the pressure value being a pressure value of the fluid in
the blood passage or of the gas in the gas filled portion, the level value being a level value of the fluid in the chamber,
the volume value being the value of the gas filled portion or of the liquid filled portion of the chamber;

e. while the shut-off device is closed, controlling the pump to pump an amount of the liquid into the blood passage;
f. receiving a second parameter data from the sensor, said second parameter data being chosen in a group comprising a pressure
data generated by the pressure sensor or a fluid level data from the level sensor, a volume data from the capacitive sensor,
while the shut-off device remains closed and the modified amount of the liquid is in the blood passage;

g. determining either a second pressure value based on the second parameter data or a second level value based on the first
parameter data or a first volume value based on the first parameter data, and

h. determining a dimensional characteristic of the blood passage based on the second pressure value or the second level value
and/or the second volume value and the modified amount of the liquid.

US Pat. No. 9,827,366

INFUSION SITE FOR IMPROVED MIXING OF FLUIDS

Gambro Lundia AB, Lund (...

1. A blood line for extracorporeal blood or plasma treatment comprising:
a first line portion intended to be connected to an outlet of a filter, the first line portion having a first line passage
section,

a second line portion intended to be connected to a patient's vascular access, the second line portion having a second line
passage section,

a post-infusion line portion for a solution at least partially reestablishing blood ion balance, the post-infusion line portion
having a post-infusion line passage section,

an infusion site acting between the first line portion and the second line portion, and intended to inject into the blood
line a solution reestablishing blood or plasma ion balance, comprising:

a first main channel in fluid communication with the first line portion and having a first passage section,
a second main channel in fluid communication with the second line portion and having a second passage section,
means for formation of a turbulence area located downstream from and in fluid communication with the first main channel, located
upstream from and in fluid communication with the second main channel, the means for formation of a turbulence area comprising
a first fluid passage means defining a reduction in a passage section and whose smallest passage section is smaller than the
first passage section and smaller than the second passage section, wherein the first fluid passage of the turbulence area
formation means defines a continuous narrowing of internal section in the direction of fluid passage,

a secondary channel in fluid communication with the post-infusion line portion, the secondary channel comprising an inlet
for letting in a solution reestablishing ion balance and an outlet in fluid communication with at least one of three elements
chosen among the first main channel, the means for formation of a turbulence area and the second main channel, wherein

the longitudinal axis of the secondary channel of the infusion site is perpendicular to the longitudinal axis of the second
main channel of the infusion site,

the post-infusion line portion is coupled internally of the secondary channel, an outer surface of the post-infusion line
portion being sealingly connected to an inner surface of the post-infusion line passage section,

the turbulence area formation means includes a second fluid passage means downstream from the first fluid passage means defining
an increase in fluid passage section, and

the largest fluid passage section of the second fluid passage means is smaller than said first passage section and smaller
than said second passage section.

US Pat. No. 10,092,686

DIALYSIS MACHINE, METHOD OF CONTROLLING THE DIALYSIS MACHINE, AND COMPUTER PROGRAM FOR IMPLEMENTING THE CONTROL

GAMBRO LUNDIA AB, Lund (...

1. A dialysis machine comprising:a fluid circuit for providing a dialysis fluid to a dialyser;
a first valve enabling a disinfectant fluid to be provided to at least a part of the fluid circuit during disinfection of the dialysis machine, the first valve including a disinfectant fluid port and a fluid circuit port; and
a pump configured to pump the dialysis fluid through the fluid circuit to the dialyser during treatment, thereby creating a positive pressure gradient between the disinfectant fluid port and the fluid circuit port of the first valve,
wherein the first valve is arranged to enable the disinfectant fluid to be provided upstream of the dialyser at a position in the fluid circuit where the pump creates the positive pressure gradient during treatment, the positive pressure gradient enabling the disinfectant fluid port of the first valve to be safely connected to a source of disinfectant fluid to ensure that said disinfectant fluid does not leak into the fluid circuit during treatment.

US Pat. No. 9,925,321

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment, comprising:at least a treatment unit having at least a first chamber and at least a second chamber separated from one another by a semipermeable membrane;
at least a blood removal line connected to an inlet port of the first chamber and configured to remove blood from a patient;
at least a blood return line connected with an outlet port of the first chamber and configured to return treated blood to the patient, the blood removal line, the blood return line and the first chamber part of an extracorporeal blood circuit;
a dialysate circuit comprising:
at least a dialysis line connected to the inlet port of the second chamber and configured to convey fresh dialysis liquid to the second chamber,
at least a fluid evacuation line connected to an outlet port of the second chamber and configured to discharge spent dialysis liquid exiting from the second chamber, and
a fluid preparation section connected to the dialysis line and configured for adjusting the dialysis liquid conductivity, or the dialysis liquid concentration for at least one substance, in the fresh dialysis liquid;
at least one ultrafiltration device connected to the dialysate circuit and configured for causing ultrafiltration of fluid through the membrane from the first to the second chamber; and
a control unit connected to the ultrafiltration device and to the fluid preparation section and programmed to perform a first control procedure comprising:
receiving measured values of:
a first parameter (BV %mes(t)) relating to the change of blood volume in the blood circulating in the extracorporeal blood circuit between start of the treatment and a respective treatment time instant (t), and
a second parameter related to the amount of ultrafiltration volume (UFmes(t); WLmes(t)) cumulated until treatment time instant (t) from the start of the treatment;
receiving prescription values of the first parameter (BV %traj(t)), and of the second parameter (UFtraj(t); WLtraj(t)) which have to be reached in the patient at treatment time instant (t); and
controlling the ultrafiltration of fluid through said membrane, by acting on the ultrafiltration device, at least based on the measured values of the first and second parameters and on the prescription values of the same first and second parameters;
the control unit also programmed to perform a second control procedure comprising:
receiving a measured value of a third parameter (Cbmes(t)) related to the blood conductivity, or to the blood concentration for at least one substance, in the blood circulating in the extracorporeal blood circuit at the respective treatment time instant (t), wherein the step of receiving the measured value of the third parameter comprises comparing one or more measured values of the conductivity or the concentration of at least one substance in the spent dialysis liquid flowing in the spent dialysis line with one or more value of the conductivity or concentration of at least one substance in the fresh dialysis liquid;
receiving a prescription value of the third parameter (Cbtraj(t)) to be reached in the patient at the time instant (t); and
controlling the fluid preparation section to adjust the dialysis liquid conductivity (CD), or the dialysis liquid concentration of at least one substance (NaD), in the fresh dialysis liquid flowing in the dialysis line at least based on said measured value (Cbmes(t)) and on said prescription value for the third parameter (Cbtraj(t)).

US Pat. No. 9,844,620

BLOOD SET COMPONENT CONNECTION DETECTION

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment system comprising:
an air pump apparatus;
one or more pressure transducers;
a controller operatively coupled to the air pump apparatus and the one or more pressure transducers;
a system housing to contain at least the air pump apparatus, the controller, and the one or more pressure transducers; and
an extracorporeal blood set comprising a plurality of components configured to be mounted on the system housing of the extracorporeal
blood treatment system using connection apparatus, wherein the connection apparatus comprises one or more ports to connect
the one or more pressure transducers contained in the system housing to one or more components of the plurality of components
of the extracorporeal blood set when mounted on the system housing, wherein the controller is configured to:

control the air pump apparatus to provide air to at least one port of the one or more ports and within at least a portion
of one or more components when mounted on the system housing using the connection apparatus; and

monitor air pressure resulting from the provision of air to the at least one port using at least one of the one or more pressure
transducers to detect whether one or more components of the plurality of components are operatively connected to the system
housing.

US Pat. No. 9,833,561

OCCLUSION DETECTION IN DELIVERY OF FLUIDS

Gambro Lundia AB, Lund (...

1. A system to detect abnormalities in delivery of a fluid comprising:
an infusion apparatus controllable to provide a fluid flow at an infusion flow rate, wherein the infusion apparatus is further
controllable to intermittently deliver a defined volume of fluid resulting in one or more perturbations in the fluid flow;

a force transducer configured to measure a perturbed force response over time resulting from each of the one or more perturbations;
and

a controller configured to:
control the infusion apparatus to provide a fluid flow at an infusion flow rate and to cause one or more perturbations in
the fluid flow, wherein each of the one or more perturbations in the fluid flow result in a measurable perturbed force response;

receive a force signal representative of a perturbed force response comprising at least a maximum perturbation force resulting
from at least one perturbation caused in the fluid flow;

determine an integrated perturbed force response value using integration of the force signal over a perturbation time period,
the integrated perturbed force response value being representative of an additional force caused by the at least one perturbation
over an equilibrium force;

provide a unitless ratio corresponding to the at least one perturbation between the integrated perturbed force response value
and a normalizing value, wherein the normalizing value is based at least on the maximum perturbation force; and

determine fluid flow occlusion based on the unitless ratio corresponding to the at least one perturbation.

US Pat. No. 10,039,783

DIALYSIS FORMULATION

GAMBRO LUNDIA AB, Lund (...

1. A replacement fluid for dialysis treatment, the replacement fluid comprising:selenium in a concentration of 0.6-1.8 ?M; and
rubidium in a concentration of 1.4-4.2 ?M, the replacement fluid being essentially free of one or more of the trace elements selected from chromium, manganese, and copper.

US Pat. No. 10,016,551

METHOD OF DISPLAYING A PREDICTED STATE, MEDICAL APPARATUS AND COMPUTER PROGRAM

GAMBRO LUNDIA AB, Lund (...

1. A method of displaying a predicted state of a medical apparatus, the method comprising:receiving, continuously or repeatedly during operation of the medical apparatus, a sensor signal from a sensor of the medical apparatus;
filtering the sensor signal by an adaptive filter such that a predicted signal is achieved;
determining a state from the predicted signal; and
displaying an indication of the predicted state of the medical apparatus through a user interface of the medical apparatus based on the determined state.

US Pat. No. 10,004,762

DIALYSIS FORMULATION

GAMBRO LUNDIA AB, Lund (...

1. A dialysis formulation comprising:selenium (Se) in a concentration of 0.5-2.5 ?M; and
rubidium (Rb) in a concentration of 0.1-4.7 ?M, the dialysis formulation being essentially free of one or more of the trace elements selected from chromium (Cr), manganese (Mn) and copper (Cu).

US Pat. No. 9,913,940

ESTABLISHING A WIRELESS COMMUNICATION BETWEEN A FLUID PROCESSING MEDICAL DEVICE AND A MEDICAL ACCESSORY

Gambro Lundia AB, Lund (...

1. A method of establishing a wireless operating communication between a fluid processing medical device and a medical accessory,
the method comprising:
establishing a wireless auxiliary communication between the fluid processing medical device and the medical accessory;
transferring configuration data using the wireless auxiliary communication; and
establishing a wireless operating communication between the fluid processing medical device and the medical accessory based
on the configuration data, wherein a maximum operating distance of the wireless auxiliary communication is shorter than a
maximum operating distance of the wireless operating communication;

wherein, after the wireless operating communication has been established, the method further comprises:
establishing a second wireless auxiliary communication between the fluid processing medical device and a second medical accessory;
transferring second configuration data using the second wireless auxiliary communication;
determining whether the medical accessory and the second medical accessory are of a same type based on the configuration data
and the second configuration data; and

if the medical accessory and the second medical accessory are of the same type:
inhibiting data communication using the wireless operating communication with the second medical accessory; and
closing the second wireless auxiliary communication.
US Pat. No. 9,833,470

DIALYSIS PRECURSOR COMPOSITION

Gambro Lundia AB, Lund (...

1. A dialysis acid precursor composition for use in preparation of a dialysis acid concentrate solution and for mixing with
water and a bicarbonate containing concentrate into a ready-for-use dialysis solution, the dialysis acid precursor composition
comprising:
powder components comprising sodium chloride, at least one dry acid, an anhydrous calcium chloride powder, and magnesium chloride
4.5-hydrate (MgCl2.4.5H2O), wherein the anhydrous calcium chloride powder is in a quantity such that a concentration of 30-125 mM calcium ions is
provided in the dialysis acid concentrate solution.

US Pat. No. 9,821,106

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A CONTROL METHOD THEREFOR

Gambro Lundia AB, Lund (...

1. A method for reducing the risk of infusion of gas microbubbles in a patient, the method comprising:
moving a first actuator to generate a variable flow comprising a constant flow component of a desired flow value and a variable
flow component oscillating about the constant flow component, the variable flow component having a substantially nil average
value, the variable flow component generating in an expansion chamber a pressure progression that is variable in time, the
pressure progression comprising a pressure component oscillating about a mean value;

receiving from at least one sensor associated with the expansion chamber and configured to sense pressure values internally
of the expansion chamber, a plurality of pressure values for a time period comprising a plurality of pressure oscillations
about the mean value, the pressure values being measured at successive time instants;

calculating, as a function of the pressure values, a control value that is representative of the oscillating pressure component;
comparing the control value representing the oscillating pressure component with a reference threshold; and
determining, following the comparison, the occurrence or not of a condition of variation of a level in the expansion chamber.

US Pat. No. 10,086,123

INTEGRATED DEVICE FOR LIVER SUPPORT SYSTEM

Gambro Lundia AB, Lund (...

1. An integrated filter module for the treatment of fluids, comprising(a) a cylindrical filter housing;
(b) a bundle of essentially parallel hollow fiber membranes distributed longitudinally within the cylindrical filter housing;
(c) a filtrate space, which is closed off from a lumen space of the hollow fiber membranes and which is in fluid communication with an inlet means and optionally an outlet means;
(d) the inlet means for feeding fluid into one of the filtrate space and the lumen space of the hollow fiber membranes;
(e) the outlet means for removing the fluid from the lumen space of the hollow fiber membranes, and optionally a second outlet means for removing treated fluid from the filtrate space;
wherein the hollow fiber membranes are prepared from at least one hydrophobic polymer selected from the group consisting of polysulfones, polyethersulfones, polyaryethersulfones, polyamides and polyacrylonitriles and at least one hydrophilic polymer and have incorporated therein at least one of 5-40 wt.-% of ion exchange particles and 5-40 wt.-% of hydrophobic particles, and
wherein the filtrate space is populated with at least one of hydrophobic particles and ion exchange particles at a filling ratio of between 0.6 and 1.0, wherein the filling ratio is the volume in ml of the maximal amount of particulate material which can be accommodated in the filtrate space of a given hollow fiber membrane module (VPM) and the utilizable volume in ml of the filtrate space of said module (VFS):

wherein VPMmresents the volume of the particulate material which can be accommodated in the filtrate space of the module, and VFS represents the utilizable filtrate space, and wherein VPM is calculated from

wherein mPM represents the amount of particulate material which can be accommodated in the filtrate space of the module and p represents the tapping density of the particulate material according to DIN ISO 3953.

US Pat. No. 9,895,109

MONITORING OF CARDIAC ARREST IN A PATIENT CONNECTED TO AN EXTRACORPOREAL BLOOD PROCESSING APPARATUS

Gambro Lundia AB, Lund (...

1. A monitoring device, comprising:
an input block configured to obtain a first pressure signal from a first pressure sensor and a second pressure signal from
a second pressure sensor, the first and second pressure sensors arranged in an extracorporeal blood processing apparatus to
detect pressure variations in a fluid which is pumped through a blood processing unit in the extracorporeal blood processing
apparatus, wherein the extracorporeal blood processing apparatus is connected to a vascular system of a subject and includes
at least one blood pumping device operable to pump blood from the vascular system through the blood processing unit and back
to the vascular system;

a processing block configured to repeatedly process the first pressure signal and the second pressure signal for generation
of a time-sequence of parameter values indicative of pressure pulsations originating from heartbeats in the subject; and

an evaluation block configured to (i) evaluate the parameter values according to a detection criterion for cardiac arrest,
which is set to detect a disappearance of the pressure pulsations originating from the heartbeats in the first pressure signal
and the second pressure signal, and, (ii) if the detection criterion is fulfilled, generate an alarm signal that signals a
cardiac arrest in the subject.

US Pat. No. 9,860,302

METHOD, CONTROL MODULE, APPARATUS AND SYSTEM FOR TRANSFERRING DATA

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising a display and a control module, wherein the control module is configured
to:
retrieve data pertaining to an operation of the extracorporeal blood treatment apparatus;
analyse the data to determine whether a certain apparatus status has occurred;
encode the data into a machine readable graphical representation adapted for presentation on the display, wherein the machine
readable graphical representation is adapted to be decoded at a remote server to recover the retrieved data; and

display the machine readable graphical representation on the display, wherein the machine readable graphical representation
is displayed on a first screen of the display when the certain apparatus status has occurred, and the machine readable graphical
representation is displayed on a second screen of the display if the certain apparatus status has not occurred.

US Pat. No. 9,836,185

EXTRACORPOREAL BLOOD TREATMENT DATA INTERFACE

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment system comprising:
a display apparatus comprising a graphical user interface to assist a user in viewing historical data associated with one
or more blood treatments, wherein the graphical user interface is configured to depict a two-dimensional graph and a time
interval selection region, wherein the two-dimensional graph defines a time axis representing time and a value axis extending
relative to the time axis and representing at least one value associated with a blood treatment or the blood treatment system
used to carry out the blood treatment, wherein the two-dimensional graph defines a viewable time frame extending from a first
end region to a second end region along the time axis, and wherein the graphical user interface is further configured to depict
an event type selection region;

an input interface configured to allow a user to select one or more of a plurality of historical datasets associated with
the blood treatment or the blood treatment system used to carry out the blood treatment to be plotted on the two-dimensional
graph; and

a computing apparatus operatively coupled to the display apparatus and the input interface, wherein the computing apparatus
is configured to:

record data during a blood treatment, wherein the data comprises at least alarms occurring during the blood treatment and
datasets associated with the blood treatment or the blood treatment system used to carry out the blood treatment,

display on the graphical user interface the time interval selection region;
allow a user to use the input interface to select a time interval of a plurality of different time intervals using the time
interval selection region of the graphical user interface, wherein the plurality of different time intervals comprise at least
one dynamic time interval, wherein the at least one dynamic time interval is a time interval that is determined as a function
of an occurrence of at least one event associated with the treatment or the blood treatment system,

display the one or more selected historical datasets associated with the blood treatment or the blood treatment system used
to carry out the blood treatment plotted on the two-dimensional graph of the graphical user interface for the selected time
interval in the viewable time frame,

display an event type selection region on the graphical user interface;
allow a user to use the input interface to select one or more event types of a plurality of different event types using the
event type selection region of the graphical user interface, wherein the plurality of different event types comprises at least
alarms occurring during a blood treatment; and

display on the graphical user interface one or more graphical elements representing events of the one or more selected event
types comprising at least alarms at locations proximate the two-dimensional graph when the events comprising at least alarms
occurred during a blood treatment in the viewable time frame.

US Pat. No. 9,801,991

DISPOSABLE CASSETTE WITH LUER LOCKS AND METHOD FOR PACKAGING

Gambro Lundia AB, Lund (...

1. An extracorporeal circuit comprising:
lines which include passages for blood or a medical liquid;
a connector at a free end of each of the lines;
a cassette supporting the lines; and
dummy connectors attached to the cassette and each adapted to form a mating connection with a respective one of the connectors
at the free ends of the lines, wherein a first group of the dummy connectors is attached to a sidewall of the cassette and
a second group of the dummy connectors is attached to a front wall of the cassette, and

wherein the connectors are arranged in accordance with a sequence in which the lines are attached for a blood treatment session
or are grouped in accordance with types of liquids to flow through the lines during the blood treatment session.

US Pat. No. 9,779,212

APPARATUS, PROCESS AND SYSTEM FOR MONITORING A PLURALITY OF PATIENTS AFFECTED BY KIDNEY FAILURE

Gambro Lundia AB, Lund (...

1. A system for monitoring a plurality of patients affected by kidney failure over a time frame covering a plurality of blood
treatment sessions, the system comprising:
a plurality of blood treatment machines for the treatment of the monitored patients, each blood treatment machine including
at least one respective control unit and sensors for measuring session parameters, the control unit of each blood treatment
machine being configured to:

receive from the sensors signals corresponding to values (VM) of a plurality of session parameters measured during each blood treatment session for each patient, and

receive set values (VS) of a plurality of prescription parameters, said set values of prescription parameters comprising values of a plurality of
session parameters which are set on said blood treatment machines for the blood treatment sessions of each patient over said
time frame (T);

a number of laboratory storage units configured to store values (VL) of laboratory parameters relating to patient blood properties obtained from tests conducted on fluid samples taken from
each patient;

a hub module communicatively connected to the blood treatment machines and to the laboratory storage units, the module comprising
a control unit configured to:

receive from said blood treatment machines and for each monitored patient, values (VM) of the plurality of session parameters measured by the sensors of each blood treatment machine during each blood treatment
session of each patient over said time frame (T),

receive from said blood treatment machines and for each monitored patient, set values of (VS) of prescription parameters set for each blood treatment session of each patient over said time frame,

receive from the laboratory storage units values (VL) of laboratory parameters obtained from tests conducted on fluid samples taken from each patient over said time frame, and

create a key parameter log storing values (KPVi) of selected parameters (KPi) comprising:

values of a first subgroup of said plurality of session parameters (VM),

set values of a second subgroup of the plurality of prescription parameters (VS),

values of a third subgroup of said plurality of laboratory parameters (VL); and

a plurality of client units each configured for reading the data coming from the key parameter log and each further configured
to:

store, for each patient, the values (KPVi) of the selected parameters (KPi) contained in the key parameter log,

define, for each of said patients, a number of indicators (IDk) wherein each of said indicator is distinct from the other and is defined based on the values (KPVi,k) taken by a respective subclass (KPi,k) of said selected parameters (KPi),

compare the values (KPVi,k) taken, over the time frame (T), by the subclasses of selected parameters (KPi,k) affecting a same indicator (IDk) with respective reference criteria;

signal whether one or more of said criteria are not met.

US Pat. No. 10,102,925

EXTRACORPOREAL BLOOD TREATMENT MACHINE

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment system comprising:a disposable set including an extracorporeal blood circuit; and
an extracorporeal blood treatment machine including
a blood pump;
a housing configured to receive the disposable set so as to operably associate the extracorporeal blood circuit with the blood pump;
a user interface including a touch screen;
at least one intransient memory device comprising
code corresponding to a first operating instruction including textual guidance describing in word form how to perform a first procedural step for preparing the machine for use,
code corresponding to a second operating instruction including textual guidance describing in word form how to perform a second procedural step for preparing the machine for use,
code corresponding to a first image including a first pictograph of the machine in a first configuration correlated to the first operating instruction to illustrate in graphical form how to perform the first procedural step for preparing the machine for use according to the first operating instruction, such code also corresponding to a schematic representation of the disposable set operatively associated with the machine and visually accentuating a first portion of the disposable set,
code corresponding to a second image including a second pictograph of the machine in a second configuration correlated to the second operating instruction to illustrate in graphical form how to perform the second procedural step for preparing the machine for use according to the second operating instruction, such code also corresponding to a schematic representation of the disposable set operatively associated with the machine and visually accentuating a second portion of the disposable set different from the first portion; and
at least one processor configured to
display on the touch screen a first touch key and a second touch key contemporaneously with the first operating instruction and the second operating instruction,
detect activation of the first touch key or the second touch key,
display the first image on the touch screen when the first touch key is activated, and
display the second image on the touch screen when the second touch key is activated.

US Pat. No. 10,005,044

VIRUS FILTER

GAMBRO LUNDIA AB, Lund (...

1. A porous hollow fiber membrane having a homogeneous sponge-like structure free of macrovoids having a largest dimension of more than 5 ?m, the membrane comprising:75-85 wt % of polyacrylonitrile and 15-25 wt % of polyvinylpyrrolidone, relative to the total weight of the membrane, wherein the polyvinylpyrrolidone has a weight average molecular weight in the range of from 1,000 to 2,000 kDa, wherein the membrane is prepared from a polymer solution comprising, relative to the total weight of the polymer solution, from 8 to 12 wt % of polyacrylonitrile and from 2 to less than 6 wt % of polyvinylpyrrolidone, and the membrane has a sieving coefficient for IgG, determined by dead-end filtration of a solution of 15.0 g/l IgG in PBS buffer at 25° C., of greater than 0.9, and a Gold Particle Retention (GPR) value for 20 nm gold particles, measured at 25° C., of greater than 1.7.

US Pat. No. 9,999,715

BLOOD TREATMENT APPARATUS ADAPTED TO PRESERVE PARTS THEREOF

GAMBRO LUNDIA AB, Lund (...

1. A blood treatment apparatus adapted to preserve a blood treatment unit between blood treatment sessions, the blood treatment apparatus comprising:the blood treatment unit;
a blood line configured to pass blood through the blood treatment unit and deliver treated blood to a target vessel;
a fluid line configured to pass treatment fluid through the blood treatment unit and,
a processor configured to cause the blood treatment apparatus to:
perform a blood treatment session during which the blood treatment unit is used to treat blood,
fill the blood treatment unit with a preservation fluid comprising at least one treatment fluid concentrate of a type that is used to prepare the treatment fluid, the at least one treatment fluid concentrate comprising sodium chloride and at least one of hydrochloric acid, citric acid, acetic acid, N-acetylcysteine, ascorbic acid, ketoglutarate and gluconic acid, and having a pH value less than 4.5,
maintain the preservation fluid in the blood treatment unit until a next blood treatment session is prepared,
dispatch the preservation fluid from the blood treatment unit and rinse the blood treatment unit with the treatment fluid in preparation of a next blood treatment session, and
perform a next blood treatment session using the blood treatment unit to treat blood.

US Pat. No. 9,925,323

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND METHOD OF OPERATION

Gambro Lundia AB, Lund (...

1. A system for monitoring the presence of blood in an extracorporeal blood circuit according to a monitoring procedure comprising:a blood detector configured to (i) receive a portion of the extracorporeal blood circuit and (ii) generate a blood presence signal indicative of whether the presence of blood has been detected in the received portion;
a pressure sensor configured to provide a differential pressure value which represents the pressure between the pressure on a first side of a blood side of a membrane device in the blood circuit and the pressure on a second side of the blood side of the membrane device; and
a control unit connected to the blood detector and the pressure sensor, wherein the control unit is configured to (a) determine the presence of blood in the membrane device based on the differential pressure value,
(b) receive the blood presence signal from the blood detector, (c) determine if the blood presence signal coincides with the determination of the presence of blood in the membrane device based on the differential pressure value, and (d) generate a signal if the determination of (c) is that the blood presence signal does not coincide with the determination of the presence of blood in the membrane device based on the differential pressure value.

US Pat. No. 10,010,665

AIR SEPARATOR FOR EXTRACORPOREAL FLUID TREATMENT SETS

GAMBRO LUNDIA AB, Lund (...

1. An air separator for extracorporeal fluid treatment sets comprising:a first chamber where fluid can be received, the first chamber presenting:
a bottom wall,
a top wall, and
a lateral wall extending between the top and bottom walls,
an inlet and an outlet port associated to the bottom wall and in fluid communication with the first chamber,
a first channel having a first portion at a first end connected to the inlet port, and a second portion at a second end terminating into the first chamber, the first channel extending along at least a portion of the lateral wall and having the first end connected to the inlet port, the second end terminating in an orifice which is closer to the top wall than to the bottom wall, the orifice opening into the first chamber facing the top wall and extending along a plane perpendicular to the lateral wall, and wherein
a filter engaged to the bottom wall in correspondence of the outlet port and axially extending into the first chamber according to a direction substantially parallel to the first channel, the filter presenting an overall axial extension which is not greater than 70% of the overall longitudinal extension of the first channel,
which includes a ratio A1/A2 greater than 0.25 and less than 0.75, wherein
A1 represents a measure of a flow passage cross section area of the orifice facing the top wall, and
A2 represents a measure of a flow passage cross section area of the first chamber in correspondence of a section horizontally aligned with the orifice and lying in the plane of the orifice,
which includes a ratio A1/A3 between 1.5 and 2.5, wherein
A3 represents a measure of a flow passage cross section area of the first portion of the first channel, and
which includes a ratio D2/D1 greater than 0.5, wherein
D1 represents a measure of a distance between a top wall inner surface of the first chamber and a bottom wall inner surface of the first chamber, and
D2 represents a measure of a distance between a horizontal plane within which the orifice of the first channel extends and the bottom wall inner surface of the first chamber.

US Pat. No. 10,065,003

SYRINGE PUMP ENGAGEMENT DETECTION APPARATUS AND METHODS

Gambro Lundia AB, Lund (...

1. A syringe pump apparatus configured to detect engagement between a drive system and a plunger of a syringe in the syringe pump apparatus, the syringe pump apparatus comprising:a syringe retainer configured to retain the syringe in a fixed position in the syringe pump apparatus;
a flow control device configured to prevent flow into the syringe retained in the syringe retainer;
a plunger clip configured to capture the plunger of the syringe retained in the syringe retainer;
a drive system configured to move the plunger clip relative to the syringe retainer;
a force sensor configured to measure a force exerted on the plunger clip by the drive system; and
a control unit operably connected to the drive system and the force sensor, wherein the control unit is configured to:
control the drive system to move the plunger clip away from the syringe retainer; and
make a determination that the plunger clip is properly engaged with the plunger of the syringe retained in the syringe retainer if the force measured by the force sensor reaches or exceeds a selected force level while the flow control device prevents flow into the syringe.
US Pat. No. 9,925,155

DIALYSIS COMPOSITION

Gambro Lundia AB, Lund (...

10. A process for manufacturing the acid concentrate dialysis composition of claim 1, the process comprising:a) dissolving sodium chloride in water;
b) dissolving electrolytes by mixing with the mixture of a);
c) dissolving citric acid;
d) mixing the sodium chloride, electrolytes, and citric acid as of a, b and c to obtain a mixture; and
e) adding citrate to the mixture obtained in d) to obtain the acid concentrate dialysis composition, wherein step a), b), c), and d) are performed sequentially, in any order, or two or more steps simultaneously.

US Pat. No. 10,130,745

PACKAGING OF POWDERY MATERIAL FOR PREPARATION OF A MEDICAL SOLUTION

GAMBRO LUNDIA AB, Lund (...

20. A package for storing powdery material which is to be mixed with a solvent to form a medical solution, said package comprising:a filled cavity portion containing the powdery material,
a tab portion connected to the filled cavity portion, the tab portion sized to wrap around the filled cavity portion at least one time and including an empty cavity portion configured to receive the powdery material from the filled cavity portion when the tab portion is unwrapped from the filled cavity portion, wherein the tab portion being swept around the filled cavity portion generates a force sufficient to maintain the powdery material in the filled cavity portion, and wherein the tab portion being unrolled from the filled cavity portion releases the force such that communication between the filled cavity portion and the empty cavity portion may be established; and
a connector attached to the tab portion for admitting the solvent to enable mixing of the powdery material with the solvent to form the medical solution.

US Pat. No. 10,002,190

MEDICAL TREATMENT DEVICE WITH SPEAKER SOUND DETECTION

Gambro Lundia AB, Lund (...

1. A medical treatment device for use in providing a treatment to a patient, the medical treatment device comprising:a speaker operable to broadcast one or more types of sounds, wherein the one or more types of sounds comprise at least one of an alarm sound and a test sound, wherein the alarm sound comprises a plurality of spaced apart notes with each note having a duration, an amplitude, and a frequency, wherein each test sound comprises a note having a duration, an amplitude, and a frequency, wherein each type of sound is associated with a predefined sound signature, wherein the sound signature corresponding to an alarm sound comprises criteria based at least on the amplitude and duration of at least two notes of the plurality of spaced apart notes, and further wherein the sound signature corresponding to a test sound comprises criteria based on the amplitude and duration of the note thereof;
an acoustic transducer to generate a sound signal representative of a sound when broadcast by the speaker; and
processing circuitry configured to:
command the speaker to broadcast a sound of the one or more types of sounds;
monitor and store the sound signal generated by the acoustic transducer during a time period when the speaker is expected to broadcast the sound; and
determine if the speaker was operable to broadcast the sound and whether the sound was audible to a user by comparing the stored sound signal to the sound signature associated with the type of sound commanded to be broadcast.

US Pat. No. 10,258,733

APPARATUS AND METHOD OF CONTROLLING AN EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. A method for reducing the risk of infusion of gas microbubbles in a patient, the method comprising:moving a first actuator to generate a variable flow comprising a constant flow component of a desired flow value and a variable flow component oscillating about the constant flow component, the variable flow component generating in an expansion chamber a pressure progression that is variable in time, the pressure progression comprising a pressure component oscillating about a mean value;
receiving from at least one sensor associated with the expansion chamber and configured to sense pressure values internally of the expansion chamber, a plurality of pressure values for a time period comprising a plurality of pressure oscillations about the mean value, the pressure values being measured at successive time instants;
calculating, as a function of the pressure values, an average pressure value;
acquiring an estimated volume variation value in the expansion chamber linked to the variable flow component;
calculating, as a function of the pressure values in the expansion chamber, an estimated pressure variation value that is representative of the oscillating pressure component; and
determining a magnitude that is representative of a level in the expansion chamber as a function of the average pressure value, the estimated volume variation value and the estimated pressure variation value.

US Pat. No. 9,962,476

INDIVIDUAL PUMP CALIBRATION FOR ULTRAFILTRATION CONTROL IN A DIALYSIS APPARATUS

GAMBRO LUNDIA AB, Lund (...

1. A dialysis apparatus, comprising:a dialyzer;
a dialysis fluid distribution system connected for fluid communication with the dialyzer and comprising a first pump, a second pump, a calibration chamber, and a fluid level detector for sensing a level of dialysis fluid in the calibration chamber, the dialysis fluid distribution system being operable to selectively establish a main flow path that extends from the first pump to the second pump via the dialyzer, and a bypass flow path that bypasses the dialyzer and extends from the first pump to the second pump in fluid communication with the calibration chamber;
a control unit electrically connected to the dialysis fluid distribution system and being operable to control a respective frequency of the first and second pumps, wherein the first and second pumps are configured to generate a respective flow rate by repeatedly discharging, at the respective frequency, a respective stroke volume of dialysis fluid;
wherein the control unit is configured to, in a calibration mode, perform a first and second measurement procedure while operating the dialysis fluid distribution system to establish the bypass flow path;
wherein the first measurement procedure comprises:
controlling the first and second pumps to operate at a first combination of frequencies that results in a first flow rate difference between the flow rates generated by the first and second pumps, and
measuring, by the fluid level detector, a first time period corresponding to a first change in dialysis fluid level in the calibration chamber as a result of the first flow rate difference, the first change in dialysis fluid level corresponding to a first known volume in the calibration chamber;
wherein the second measurement procedure comprises:
controlling the first and second pumps to operate at a second combination of frequencies that differs from the first combination of frequencies and results in a second flow rate difference between the flow rates generated by the first and second pumps, and
measuring, by the fluid level detector, a second time period corresponding to a second change in dialysis fluid level in the calibration chamber as a result of the second flow rate difference, the second change in dialysis fluid level corresponding to a second known volume in the calibration chamber;
wherein the control unit is further configured to compute at least one of the stroke volumes of the first and second pumps as a function of the first and second combinations of frequencies, the first and second time periods, and the first and second known volumes; and
wherein the function is obtained by solving a system of equations that equates the first known volume to an accumulated difference between the flow rates generated by the first and second pumps during the first time period, and that equates the second known volume to an accumulated difference between the flow rates generated by the first and second pumps during the second time period.

US Pat. No. 10,201,648

FILTER MODULE

GAMBRO LUNDIA AB, Lund (...

1. A single use filter module capable of on-line production of a medical fluid which is sterile, non-pyrogenic, and free from cytokine-inducing substances, comprisinga) a housing comprised of
a1) a bottom part comprising a fluid compartment and a fluid outlet positioned on the center line of the bottom part at one end of the fluid compartment;
a2) a top part comprising a fluid compartment and a fluid inlet positioned on the center line of the top part on one end wall of the fluid compartment; and
b) a positively charged microporous flat sheet membrane arranged within the housing, wherein
i) the bottom part contains a support structure consisting of a plurality of longitudinal ribs and transversal ribs;
ii) the top part contains a support structure consisting of a plurality of longitudinal ribs and transversal ribs;
iii) a protection net is arranged within the housing and located atop the longitudinal ribs of the bottom part;
iv) the positively charged microporous flat sheet membrane is located atop the protection net; and
v) a retention net is arranged within the housing and located between the positively charged microporous flat sheet membrane and the longitudinal ribs of the top part.

US Pat. No. 10,179,199

MEDICAL APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND METHOD FOR DETERMINING A BLOOD PARAMETER VALUE IN A MEDICAL APPARATUS THEREOF

Gambro Lundia AB, Lund (...

1. A medical apparatus (1) comprising:at least one machine (2) for extracorporeal blood treatment having:
at least a blood treatment unit (3);
an extracorporeal blood line (4) having a withdrawal branch (5) adapted to withdraw blood from a patient access (6) of a patient and to bring the withdrawn blood to the blood treatment unit (3) and a return branch (7) adapted to bring the blood from the blood treatment unit (3) to the patient; and
at least one hematocrit sensor (8) associated to the extracorporeal line (4) and to provide a measure of a hemoglobin value of the blood of the patient circulating in the extracorporeal blood line (4);
a control unit (9); and
at least one storage memory (10) for storing measures of the hemoglobin value, each measure being made through one of the at least one hematocrit sensor (8) of said machine (2) and each measure corresponding to different treatment sessions of patients on said machine (2);the control unit (9) being configured for performing the following steps:taking from the at least one storage memory (10) a plurality of measures of the hemoglobin value, said plurality of measures of the hemoglobin value relating to a same patient;
receiving at least an actual control hemoglobin value relating to the same patient, said actual control hemoglobin value being measured at a monitoring time, said actual control hemoglobin value being a real absolute value of hemoglobin of the blood of the same patient measured through laboratory measurements;
determining a correcting factor as a difference between a time-corresponding measure of the hemoglobin value of the plurality of measures of the hemoglobin value relating to the same patient corresponding to the monitoring time and the actual control hemoglobin value;
obtaining an actual hemoglobin value by correcting at least a last measure of the hemoglobin value made through the at least one hematocrit sensor by means of the correcting factor; and
determining an erythropoietin stimulating agent prescription based on at least the plurality of measures of the hemoglobin value and the correcting factor.

US Pat. No. 10,130,744

APPARATUS AND A METHOD FOR EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus, comprising:a blood treatment device having a blood chamber and a fluid chamber separated from one another by a semipermeable membrane;
an extracorporeal blood circuit connected to the blood chamber configured to transport blood from an individual to the blood chamber and to return the blood from the blood chamber to the individual;
a blood volume sensor configured to provide a signal corresponding to an indicative value of a blood volume variation of the individual undergoing the extracorporeal blood treatment;
a sensor configured to emit at least a signal corresponding to a weight loss variation of the individual undergoing the extracorporeal blood treatment;
a weight loss system configured to actuate weight loss of the individual during the extracorporeal blood treatment; and
a control unit configured to:
receive the signal corresponding to the weight loss variation of the individual;
receive the indicative value of the blood volume variation of the individual;
acquire a desired value of a refilling index (IRDES), the refilling index being a function of the ability of the individual to absorb the mass of liquid subtracted from the plasmatic part of the blood by the weight loss system from cells of tissues of the individual, wherein the refilling index is defined by fuction (I) of a ratio between the blood volume variation (?BV) and the weight loss variation (?WL):

determine a calculated value of the refilling index (IRCAL) as a function of the blood volume variation and a weight loss variation of the individual; and
control the weight loss system on a basis of the desired value of the refilling index and the calculated value of the refilling index based on a controlled weight loss rate for the individual (WLRi) as a function of an initially set weight loss rate for the individual (WLR0) and the desired value of the refilling index (IRDES) and the calculated value of the refilling index (IRCAL) according to the following function (II):

US Pat. No. 10,124,108

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A RELATED CONTROL METHOD

GAMBRO LUNDIA AB, Lund (...

1. An apparatus for extracorporeal blood treatment comprising:at least a treatment unit having at least a first chamber and at least a second chamber separated from one another by a semi-permeable membrane;
at least a blood removal line connected to an inlet port of the first chamber and configured to remove blood from a patient;
at least a blood return line connected to an outlet port from the first chamber and configured to return treated blood to the patient, wherein the blood removal line, the blood return line and the first chamber are part of an extracorporeal blood circuit;
at least a peristaltic pump operable with the extracorporeal blood circuit to move the blood in the circuit;
at least a pressure sensor associated to the extracorporeal blood circuit and configured to enable determination of pressure values in said extracorporeal blood circuit;
at least a fluid drainage line connected to an outlet port of said second chamber; and
a control unit connected to said at least a pressure sensor and to the peristaltic pump and programmed to:
move the peristaltic pump with a cyclic motion to generate a blood flow;
receive from said at least a pressure sensor a signal indicating the pressure of the blood in the extracorporeal blood circuit;
sample, for each cycle of the peristaltic pump, the signal indicating the blood pressure with a frequency in the time domain depending on the velocity of the peristaltic pump;
receive a signal indicating the instant blood flow in the peristaltic pump;
compare the signal with a plurality of fields indicating predefined intervals of blood flow each combined with a respective predefined sampling frequency of the signal indicating the blood pressure;
identify the field in the plurality of fields to which the signal belongs;
identify the respective predefined sampling frequency;
dimension a filter to be used on the basis of the predefined sampling frequency and at a desired cutting frequency; and
apply the filter to the sampled signal indicative of the blood pressure.

US Pat. No. 10,137,233

DETECTING PRESSURE PULSES IN A BLOOD PROCESSING APPARATUS

GAMBRO LUNDIA AB, Lund (...

1. An apparatus for extracorporeal blood processing comprising:an extracorporeal blood circuit for connection to the vascular system of a subject;
a blood processing unit in the extracorporeal blood circuit;
a blood pumping device in the extracorporeal blood circuit operable to pump blood through the blood processing unit;
a treatment fluid supply system operable to pump treatment fluid through the blood processing unit;
a first pressure sensor arranged in the extracorporeal blood circuit to detect pressure variations in the blood which is pumped through the blood processing unit;
a second pressure sensor arranged in the treatment fluid supply system to detect pressure variations in the treatment fluid which is pumped through the blood processing unit; and
a monitoring device including
a first input block configured to obtain a first pressure signal (y) from the first pressure sensor, wherein the extracorporeal blood circuit is connected to a vascular system of a subject,
a second input block configured to obtain a second pressure signal (u) from the second pressure sensor,
an emulation block configured to generate, as a function of the second pressure signal (u), an emulated first pressure signal (?) which emulates a signal response of the first pressure sensor concurrently over a period of time of the first pressure signal of the first pressure sensor,
a filtering block configured to generate a filtered signal (yf) as a function of the first pressure signal (y) and the emulated first pressure signal (?), so as to suppress, in the filtered signal (yf) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system, and
a pulse detection block configured to process the filtered signal (yf) for detection of subject pulses originating from the subject.

US Pat. No. 10,543,304

BLOOD TREATMENT APPARATUS WITH MULTIPLE AXIS MONITOR MOUNT

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising:one or more pumps located on a front face of a housing, wherein the one or more pumps are configured to move blood and a treatment solution during extracorporeal blood treatment;
a monitor comprising a display surface configured to display visual images thereon;
a monitor mount comprising a base attached to a top surface of the housing and a monitor arm attached to base and the monitor, wherein the monitor is positioned above the base and the top surface of the housing, and wherein the monitor arm is configured to:
rotate about a swivel axis that is oriented vertically through the base and the top surface of the housing such that the monitor can be rotated between a front-facing position in which the display surface faces the same direction as the front face of the housing and one of a left-facing position in which the display surface faces the same direction as a left side of the housing and a right-facing position in which the display surface faces the same direction as a right side of the housing;
rotate about a tilt axis oriented transverse to the swivel axis, wherein the tilt axis is located above the base and the top surface of the housing, wherein the monitor is configured to rotate about the tilt axis between a stowed position and an operating position, wherein in the stowed position the display surface of the monitor is oriented in a plane that is generally transverse to the swivel axis, wherein in the operating position the display surface of the monitor is oriented in a plane that is generally aligned with the swivel axis;
a control unit located within the housing and operably connected to the one or more pumps, wherein the control unit is configured to operate the one or more pumps to move blood and a treatment solution and the monitor; and
a first cable connecting the monitor to the control unit, wherein the first cable comprises a first segment generally aligned with the tilt axis and a second segment generally aligned with the swivel axis, wherein the first segment is closer to the monitor that the second segment, and wherein the second segment is closer to the control unit than the first segment, and further wherein the second segment of the first cable passes into the housing.

US Pat. No. 10,251,979

IMPLANTABLE ACCESS DEVICE AND METHOD FOR PREPARING THEREOF

GAMBRO LUNDIA AB, Lund (...

1. An implantable vascular access device comprising a shape memory base structure having openings, a substructure having openings, the substructure thereby being suitable for cell adhesion, cell engraftment and proliferation for use in transferring fluid into/out of a human or animal body, the shape memory base structure and the substructure permitting three-dimensional fixation and integration of cells on and within the access device, the shape memory base structure and the substructure together comprising a generally conical body having the shape memory base structure as a base of the generally conical body and adapted to receive a needle and a positioning end forming an apex of the generally conical body and adapted to position the end of said needle.

US Pat. No. 10,258,726

PROCESS OF CONTROLLING AN APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD

Gambro Lundia AB, Lund (...

1. A process of controlling an apparatus for extracorporeal treatment of blood, the apparatus being of the type comprising: a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane; a blood withdrawal line connected to an inlet of the primary chamber, and a blood return line connected to an outlet of the primary chamber said blood lines being designed to be connected to a patient cardiovascular system; a blood pump for controlling flow of blood through the blood lines; an effluent fluid line connected to an outlet of the secondary chamber; an ultrafiltration actuator connected to the effluent fluid line and configured to cause a transfer of fluid from the primary chamber to the secondary chamber, wherein the process comprises:controlling the ultrafiltration actuator based on a set value for a patient fluid removal rate, said set value being a setting imposed on the ultrafiltration actuator defining a rate of fluid removal from a patient,
determining when the ultrafiltration actuator is operated or when the ultrafiltration actuator is not operated,
executing, at check points during patient treatment, a control procedure comprising:
receiving check information selected from the group of:
an effective time portion of a time period preceding a check point during which said ultrafiltration actuator is operated,
and a down time portion of a time period preceding a check point during which said ultrafiltration actuator is not operated,
calculating an updated set value for said patient fluid removal rate as a function of said set value for the patient fluid removal rate and of said check information.

US Pat. No. 10,213,539

EXTRACORPOREAL BLOOD CIRCUIT WITH NON-INVASIVE PRESSURE SENSOR

Gambro Lundia AB, Lund (...

1. An apparatus configured to remove one or more substances from blood, wherein the apparatus comprises:a primary filter comprising a first semipermeable membrane separating a blood compartment from a dialysate loading compartment;
a blood circuit having a blood line connected to the blood compartment of the primary filter;
a non-invasive pressure sensor configured to directly contact any exposed longitudinal portion of an exterior surface of a circular tube forming the blood line, the non-invasive pressure sensor further configured to sense pressure in the blood line, wherein the non-invasive pressure sensor includes an outer wall forming a groove leading to a sensing portion in direct contact with the exterior surface of the blood line and does not contact liquid in the blood line, the groove narrower than the sensing portion to compress the blood line upon insertion through the groove such that the blood line when uncompressed is held within the sensing portion after the insertion; and
a control unit operably connected to the non-invasive pressure sensor and to control elements of the blood circuit, wherein the control unit is configured to:
monitor a blood circuit pressure value using the non-invasive pressure sensor and operate the control elements of the blood circuit based on the monitored blood circuit pressure value, wherein operating the control elements comprises deactivating the blood pump when the monitored blood circuit pressure indicates that the blood line is not engaged with the non-invasive pressure sensor.

US Pat. No. 10,314,965

SEPARATION OF INTERFERENCE PULSES FROM PHYSIOLOGICAL PULSES IN A PRESSURE SIGNAL

GAMBRO LUNDIA AB, Lund (...

1. A device for processing a pressure signal obtained from a pressure sensor in an extracorporeal fluid circuit, said device comprising:an input for receiving the pressure signal from the pressure sensor; and
a signal processor connected to the input and being configured to:
extract, from the pressure signal, a signal segment that comprises a sequence of interference pulses originating from an interference generator associated with the extracorporeal fluid circuit, and a sequence of physiological pulses originating from a physiological pulse generator in a subject which is connected to the extracorporeal fluid circuit;
process the signal segment for separation of the interference pulses from the physiological pulses by:
a) subtracting at least one initial template signal from the signal segment to generate a first difference signal that represents the sequence of physiological pulses and residuals of the interference pulses;
b) processing the first difference signal to generate a first template signal in which the residuals of the interference pulses are suppressed in relation to the sequence of physiological pulses;
c) subtracting at least the first template signal from the signal segment to generate a second difference signal that represents the sequence of interference pulses and residuals of the physiological pulses; and
d) processing the second difference signal to generate a second template signal in which the residuals of the physiological pulses are suppressed in relation to the sequence of interference pulses; and
evaluating a property of the extracorporeal fluid circuit using the second template signal.
US Pat. No. 10,188,991

PERMSELECTIVE ASYMMETRIC MEMBRANES

GAMBRO LUNDIA AB, Lund (...

1. A semipermeable asymmetric membrane, wherein the membrane material comprises at least one polysulfone, poly-ethersulfone, or polyarylethersulfone; and a polyvinylpyrrolidone, wherein the polyvinylpyrrolidone consists essentially of a polyvinylpyrrolidone with a weight average molecular weight Mw of more than 1,700 kDa and less than 1,900 kDa and with a number average molecular weight Mn between about 340 kDa to about 390 kDa.
US Pat. No. 10,172,881

DIALYSIS PRECURSOR COMPOSITION

GAMBRO LUNDIA AB, Lund (...

1. A ready-for-use dialysis solution comprising:a bicarbonate containing concentrate; and
a dialysis acid concentrate solution comprising powder components mixed with water, the powder components comprising a sodium chloride powder, at least one dry acid powder, an anhydrous calcium chloride powder in a quantity such that a concentration of 30-125 mM calcium ions is provided in the dialysis acid concentrate solution, and a magnesium chloride 4.5-hydrate (MgCl2.4.5H2O) powder in a quantity such that a concentration of about 7.5-50 mM magnesium ions is provided in the dialysis acid concentrate solution,
wherein the at least one dry acid is selected from the group consisting of lactic acid, citric acid, gluconic acid, glucono-?-lactone, N-acetyl cysteine and ?-lipoic acid.

US Pat. No. 10,300,190

TARGET VOLUME BASED DIAPHRAGM REPOSITIONING FOR PRESSURE MEASUREMENT APPARATUS

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment system comprising:a pressure measurement apparatus comprising:
at least a pod body portion and a base body portion; and
a diaphragm separating a fluid side cavity defined at least in part by the pod body portion from a transducer side cavity defined at least in part by the base body portion, wherein the fluid side cavity is in fluid communication with an inlet and an outlet, and further wherein the diaphragm is displaceable from a target measuring position into the fluid side cavity towards the pod body portion and is displaceable from the target measuring position into the transducer side cavity towards the base body portion;
an air pump apparatus coupled to the transducer side cavity via one or more connection elements to add air to or remove air from the transducer side cavity;
at least one pressure transducer operatively coupled to the transducer side cavity to sense air pressure therein;
a controller operatively coupled to the air pump apparatus and the at least one pressure transducer to reposition the diaphragm to the target measuring position, wherein the controller is configured to:
control the air pump apparatus to bottom out the diaphragm on the base body portion by removing air from the transducer side cavity and/or to top out the diaphragm on the pod body portion by adding air to the transducer side cavity;
monitor the air pressure in the transducer side cavity sensed by the at least one pressure transducer;
calculate a target air volume required to move the diaphragm to the target measuring position based at least on the monitored air pressure; and
control the air pump apparatus to add air to the transducer side cavity after the diaphragm is bottomed out to move the diaphragm toward a target measuring position based on the calculated target air volume or to remove air from the transducer side cavity after the diaphragm is topped out to move the diaphragm toward a target measuring position based on the calculated target air volume, wherein, as air is added to or removed from the transducer side cavity, the controller is configured to iteratively calculate the target air volume required to move the diaphragm to the target measuring position based at least on the monitored air pressure until the controller determines that the diaphragm is in the target measuring position.

US Pat. No. 10,434,236

EXTRACORPOREAL BLOOD TREATMENT APPARATUS HAVING DIALYSIS FLUID PARAMETER DATA ENTRY

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment comprising:a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;
a blood withdrawal line in fluid communication with an inlet of the primary chamber;
a blood return line in fluid communication with an outlet of the primary chamber, the blood lines configured for connection to a patient cardiovascular system;
a dialysis supply line in fluid communication with an inlet of the secondary chamber;
a dialysis effluent line in fluid communication with an outlet of the secondary chamber;
a preparation device for preparing dialysis fluid, the preparation device in fluid communication with the dialysis supply line and comprising a regulating device for regulating composition of the dialysis fluid; and
a control unit communicating with the regulating device and receiving a value representative of a first parameter, the first parameter chosen from a group including (i) a plasma conductivity, (ii) a plasma conductivity-related parameter, (iii) a concentration of at least sodium in blood, and (iv) a concentration-related parameter of at least sodium in blood, the control unit programmed to set a second parameter for the dialysis fluid in the dialysis supply line at a set point, the second parameter being at least one chosen from a group including (i) a conductivity of the dialysis fluid, (ii) a conductivity-related parameter of the dialysis fluid, (iii) a concentration of at least a substance in the dialysis fluid, and (iv) a concentration-related parameter of at least a substance in the dialysis fluid,
wherein setting the second parameter includes calculating the second parameter as a function of a main contribution term based on the first parameter and as a function of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen from a group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate and phosphate, and
wherein the adjustment contribution term is the sodium concentration set point adjustment to the sodium concentration set point for isoconductive dialysis, and wherein the adjustment contribution applied to the sodium concentration set point for the isoconductive dialysis provides a treatment chosen in the group including isotonic dialysis, isonatremic dialysis, isonatrikalemic dialysis and a treatment that removes from, or adds to, the plasma a defined amount of at least a substance.

US Pat. No. 10,391,225

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A CONTROL METHOD THEREFOR

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment comprising:at least one treatment unit comprising at least a first compartment;
at least one blood removal line in fluid communication with the first compartment and configured to remove blood from a patient;
at least one blood return line in fluid communication with the first compartment and configured to return treated blood to the patient;
the blood removal line, the blood return line and the first compartment being part of an extracorporeal blood circuit;
at least one chamber placed in the extracorporeal blood circuit, the chamber being arranged in use to contain a volume of gas in an upper portion and blood at a level in a lower portion;
at least one blood pump operating with the extracorporeal blood circuit and configured to move blood in the circuit;
at least a first pressure sensor associated with the upper portion of the chamber and configured to enable pressure values internally of the upper portion to be determined; and
a control unit operably connected to the first pressure sensor and the pump, the control unit configured to:
receive from the first pressure sensor a first signal relating to at least one pulse of pressure of the blood flow;
calculate a phase shift between the first signal and a reference signal correlated to said at least one pulse of pressure detected at a location distinct from the upper portion of the chamber, said phase shift depending on the volume of gas in the upper portion of the chamber;
monitor said volume of gas using said phase shift; and
emit an alarm signal and/or initiate a control procedure if the volume of gas is determined to be outside a predetermined threshold.

US Pat. No. 10,369,266

MULTIPART FLUID SYSTEM AND A SYSTEM FOR CITRATE ANTICOAGULATION IN AN EXTRACORPOREAL BLOOD CIRCUIT

GAMBRO LUNDIA AB, Lund (...

1. A multipart fluid system for dialysis therapy, the multipart fluid system comprising:an anticoagulation fluid; and
at least one treatment fluid from the group consisting of dialysis fluid and infusion fluids, wherein the anticoagulation fluid comprises 15-40 mM citrate, the at least one treatment fluid comprises 1.5-8 mM citrate and >10 mM bicarbonate, and wherein a level of the bicarbonate in the at least one treatment fluid is selected from a set of bicarbonate levels that satisfy a relationship in which the level of the bicarbonate is decreased with increased citrate levels in the anticoagulation fluid.

US Pat. No. 10,265,459

APPARATUS FOR DETERMINING A PARAMETER INDICATIVE OF THE PROGRESS OF AN EXTRACORPOREAL BLOOD TREATMENT

GAMBRO LUNDIA AB, Lund (...

1. An apparatus for extracorporeal blood treatment comprising:a blood treatment unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;
a preparation line in fluid communication with an inlet of the secondary chamber of the blood treatment unit and configured to convey fresh treatment liquid to the secondary chamber, the fresh treatment liquid presenting a characteristic (Cdin) which is one selected from the group of:
conductivity in the fresh treatment liquid, and
concentration of at least one substance in the fresh treatment liquid;
a spent dialysate line in fluid communication with an outlet of said secondary chamber and configured to remove spent liquid from the secondary chamber, the spent liquid presenting a characteristic (Cdout) which is one selected from the group of:
conductivity in the spent liquid, and
concentration of at least one substance in the spent liquid; and
a control unit configured to command execution of a task for determination of a parameter indicative of the effectiveness of the extracorporeal blood treatment, said task comprising:
receiving at least one prescription baseline (Cdset) for the characteristic (Cdin) in the fresh treatment liquid;
causing the fresh treatment liquid to flow in the preparation line to the secondary chamber with the characteristic being at said prescription baseline (Cdset);
causing the spent liquid to flow out of the secondary chamber into the spent dialysate line;
causing an upstream variation of the characteristic (Cdin) in the fresh treatment liquid with respect to said prescription baseline (Cdset) thereby causing a corresponding and timely delayed downstream variation of the same characteristic (Cdout) in the spent liquid flowing in the spent dialysate line;
measuring a plurality of values taken by a reference portion of said downstream variation of the characteristic (Cdout) in the spent liquid, said reference portion having duration shorter than the entire duration of the downstream variation;
determining a downstream curve (Cdout(t)) representative of the values taken by the characteristic (Cdout) in the spent liquid for the entire duration of the downstream variation;
computing one or more significant value of said downstream variation of the characteristic (Cdout), said one or more significant value of the downstream variation relating to a time subsequent to the duration of the reference portion; and
computing at least one value of a parameter indicative of the effectiveness of the extracorporeal blood treatment by using said one or more significant value of said downstream variation of the characteristic (Cdout) in the spent liquid.

US Pat. No. 10,218,411

METHOD FOR PROVIDING OPERATION DATA TO A FLUID PROCESSING MEDICAL APPARATUS USING A MEDICAL ACCESSORY

Gambro Lundia AB, Lund (...

1. A method for providing operation data to a fluid processing medical apparatus, the method comprising:providing the medical apparatus comprising a readable element readable by at least one data acquisition unit;
acquiring configuration data associated to the readable element of the medical apparatus by relatively approaching a data acquisition unit of a medical accessory and the readable element of the medical apparatus;
establishing a wireless communication between the medical accessory and the medical apparatus based on the configuration data;
providing a medical component comprising a readable element different than the readable element of the medical apparatus;
acquiring operation data associated to the readable element of the medical component by relatively approaching the data acquisition unit of the medical accessory and the readable element of the medical component, wherein the medical component is configured to be operatively coupled to the medical apparatus; and
providing the operation data to the medical apparatus using the wireless communication.

US Pat. No. 10,328,192

RELATIVE PUMP CALIBRATION FOR ULTRAFILTRATION CONTROL IN A DIALYSIS APPARATUS

GAMBRO LUNDIA AB, Lund (...

1. A dialysis apparatus, comprising:a dialyzer;
a dialysis fluid distribution system connected for fluid communication with the dialyzer and comprising a first pump and a second pump, the dialysis fluid distribution system being operable to selectively establish a main flow path that extends between the first and second pumps via the dialyzer, and a bypass flow path that bypasses the dialyzer and extends between the first and second pumps; and
a control unit electrically connected to the dialysis fluid distribution system and configured to control a respective frequency of the first and second pumps, wherein the first and second pumps are configured to generate a respective flow rate by repeatedly discharging, at the respective frequency, a respective stroke volume of dialysis fluid;
wherein the control unit is configured to, in a calibration mode,
(i) operate the dialysis fluid distribution system to establish the bypass flow path,
(ii) control the first pump to operate at a first calibration frequency and the second pump to operate at a second calibration frequency so as to balance the flow rates generated by the first and second pumps, and
(iii) determine relative calibration data that represents a relation between the stroke volumes of the first and second pumps based on the first and second calibration frequencies; and
wherein the control unit is configured to, in a treatment mode,
(i) operate the dialysis fluid distribution system to establish the main flow path,
(ii) assign a predefined nominal stroke volume to the first pump,
(iii) set a respective treatment frequency of the first pump to generate, based on the predefined nominal stroke volume of the first pump, a first flow rate of dialysis fluid,
(iv) set a respective treatment frequency of the second pump to generate a second flow rate of dialysis fluid that differs from the first flow rate by a selected ultrafiltration rate, and
(v) control the first and second pumps, based on the relative calibration data, to operate at the respective treatment frequencies of the first and second pumps to generate the selected ultrafiltration rate in the dialyzer.
US Pat. No. 10,238,785

MEMBRANE AND DEVICE FOR TREATING HEMOLYTIC EVENTS

GAMBRO LUNDIA AB, Lund (...

1. A method of removing cell-free plasma hemoglobin from blood of a patient, said method comprising the steps ofa. withdrawing and passing blood from the patient, the blood comprising a cell-free plasma hemoglobin concentration of above 0.5 g/L in a continuous flow into contact with one face of a semipermeable polymeric hollow-fiber membrane having a MWRO of between 9.0 and 20 kD and a MWCO of between 55-320 kD as determined by dextran sieving before blood contact of the membrane,
b. simultaneously passing dialysate solution in a continuous flow on the opposite face of the membrane to the side of the membrane in contact with the blood, and
c. returning the blood into the patient,
wherein the method reduces cell-free plasma hemoglobin concentration to below about 0.1 g/L.

US Pat. No. 10,485,912

EXTRACORPOREAL BLOOD TREATMENT SYSTEM FOR INDIVIDUALIZED TREATMENT

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment system comprising:a first holder, the first holder holding when the system is in use a blood treatment device having a blood chamber, a fluid chamber, and a semipermeable membrane that separates the chambers from each other;
a second holder, the second holder holding when the system is in use an extracorporeal blood circuit coupled to the blood treatment device; and
a control unit configured to operate at least one pump to cause blood to flow through the blood treatment device and the extracorporeal blood circuit, wherein the control unit is further configured to execute a procedure comprising:
prior to commencing an extracorporeal blood treatment, reading from a storage device stored values of a water-refilling index, wherein the stored values relate to a sequence of previous extracorporeal blood treatments,
processing the stored values of the water-refilling index read from the storage device according to an algorithm to determine a current value of the water-refilling index, wherein the current value is then available for a subsequent extracorporeal blood treatment, and
using a default value as the current value if less than a threshold number of stored values is read, deeming valid the current value if within a predetermined range of acceptability, and if not, discarding the current value, wherein the predetermined range of acceptability for the water refilling index is between 0.5 and 2.0.

US Pat. No. 10,456,517

INFUSION SITE FOR IMPROVED MIXING OF FLUIDS

Gambro Lundia AB, Lund (...

1. A method of anticoagulating blood treated during extracorporeal circulation in an extracorporeal circulation blood or plasma treatment device, the extracorporeal circulation blood or plasma treatment device comprising:a filter having a first compartment and a second compartment separated by a semipermeable membrane;
an arterial line in fluid communication with the first compartment of the filter;
a pre-infusion channel for a local anticoagulation substance in fluid communication with the arterial line;
a container of a local anticoagulation substance in fluid communication with the pre-infusion channel;
a venous blood line in fluid communication with the first compartment of the filter, the venous blood line comprising:
a first line portion in fluid communication with an outlet of the filter,
a second line portion in fluid communication with a patient's vascular access,
an infusion site between the first line portion and the second line portion for injecting into the blood line a solution reestablishing blood or plasma ion balance, the infusion site comprising:
a first main channel in fluid communication with the first line portion and having a first passage section,
a second main channel in fluid communication with the second line portion and having a second passage section, and
a turbulence area downstream from and in fluid communication with the first main channel, and upstream from and in fluid communication with the second main channel, the turbulence area comprising a first fluid passage defining a reduction in passage section having a smallest passage section smaller than the first passage section and smaller than the second passage section, and
a secondary channel comprising an inlet for the solution reestablishing blood or plasma ion balance and an outlet in fluid communication with at least one of the first main channel, the turbulence area and the second main channel; and
a container of solution reestablishing blood or plasma ion balance in fluid communication with the secondary channel of the infusion site via a post-infusion line;
the method comprising:
a) flowing blood or plasma through the arterial line,
b) infusing the local anticoagulation substance through the pre-infusion channel into the arterial line,
c) filtering blood through the filter,
d) flowing the filtered blood through the first line portion of the venous blood line,
e) flowing the filtered blood in the turbulence area of the infusion site to cause a turbulence in blood flow,
f) infusing the solution for reestablishing ion balance through the secondary channel of the infusion site, and
g) flowing the filtered blood mixed with the solution for reestablishing blood or plasma ion balance through the second portion of the blood line, wherein step f) is carried out directly before, during or directly after step e).

US Pat. No. 10,391,218

EXTRACORPOREAL BLOOD TREATMENT APPARATUS AND METHOD OF SETTING AN EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising:a blood treatment unit having a primary chamber configured to receive blood of a patient to be treated, and a secondary chamber separated from the primary chamber by a semi-permeable membrane;
an hydraulic circuit having a fresh fluid line configured to connect to an inlet of the secondary chamber, a spent fluid line configured to connect to an outlet of said secondary chamber and configured to remove spent liquid from the secondary chamber and convey it to at least one waste, and a bypass line configured to connect to the fresh fluid line and the spent fluid line such that fresh treatment liquid passing through the bypass line does not pass through the secondary chamber,
the hydraulic circuit comprising a fluid intercepting organ configured to selectively connect the fresh fluid line to the spent fluid line through the bypass line, wherein a control unit operably connected to the fluid intercepting organ is configured to control the fluid intercepting organ such that the hydraulic circuit selectively operates in a normal mode, where the fresh fluid line is connected to the inlet of the secondary chamber of the treatment unit to convey fresh treatment liquid only to the secondary chamber, and wherein the control unit is further configured to control the fluid intercepting organ such that the hydraulic circuit selectively operates in an isolated ultrafiltration mode, where the fresh fluid line is connected to the spent fluid line through the bypass line and the fresh fluid line does not convey fresh treatment liquid to the secondary chamber,
the control unit further configured to execute a setup phase before starting treatment, the setup phase comprising:
receiving at least two general setup values selected from:
a prescription value for a total treatment time during which the patient is to be submitted to blood treatment,
a prescription value for a total patient fluid removal to be achieved by the end of total treatment time,
a prescription value for an average patient fluid removal rate to be kept across total treatment time;
receiving instructions to execute a selected plurality of isolated ultrafiltration tasks during the total treatment time, wherein the control unit is configured to:
receive, for each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks, values of at least two isolated ultrafiltration parameters selected from:
an isolated ultrafiltration time, which is a time interval during which the apparatus is requested to operate in said isolated ultrafiltration mode,
an isolated ultrafiltration volume, which is a volume of fluid to be removed from the patient while the apparatus is requested to operate in said isolated ultrafiltration mode,
an isolated ultrafiltration rate which is a rate of fluid removal from the patient while the apparatus is requested to operate in said isolated ultrafiltration mode;
determining, during the setup phase, at least one of:
a remaining treatment time based on said isolated ultrafiltration time of each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks, the remaining treatment time being a treatment time during which the patient shall be submitted to blood treatment with the apparatus operating in normal mode after operation in isolated ultrafiltration mode,
a remaining patient fluid removal based on said isolated ultrafiltration volume of each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks, the remaining patient fluid removal being a volume of fluid to be extracted from the patient with the apparatus operating in normal mode after operation in isolated ultrafiltration mode,
a remaining patient fluid removal rate based on said isolated ultrafiltration rate of each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks, the remaining patient fluid removal rate being a rate of fluid to be extracted from the patient with the apparatus operating in normal mode after operation in isolated ultrafiltration mode;
wherein the control unit is configured to control the fluid intercepting organ such that the hydraulic circuit operates in isolated ultrafiltration mode during the total treatment time corresponding to the selected plurality of isolated ultrafiltration tasks and based on the values of at the least two isolated ultrafiltration parameters received for each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks;
wherein, when the hydraulic circuit is operating in the isolated ultrafiltration mode, the control unit is further configured to control the fluid intercepting organ to switch the hydraulic circuit from operating in the isolated ultrafiltration mode to the normal mode upon the first of:
passage of all of said isolated ultrafiltration time;
withdrawal from a patient of said isolated ultrafiltration volume; or
receipt of a command from a user interface connected to the control unit indicating to end the isolated ultrafiltration mode;
and wherein, when operating the hydraulic circuit in the normal mode after operating in the isolated ultrafiltration mode, the control unit is configured to operate the hydraulic circuit in the normal mode based on the values of two of: the remaining treatment time, the remaining patient fluid removal, and the remaining patient fluid removal rate determined during the setup phase for each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks.

US Pat. No. 10,357,600

EXTRACORPOREAL BLOOD TREATMENT SYSTEM, DISPOSABLE SET AND VALVE UNIT FOR PRE/POST INFUSION

Gambro Lundia AB, Lund (...

1. Disposable set for an extracorporeal blood treatment system, comprising:an extracorporeal blood circuit comprising a blood withdrawal line and a blood return line configured to be coupled to a blood treatment device;
an infusion circuit comprising infusion lines coupled to the extracorporeal blood circuit;
an infusion valve unit configured to be releasably connectable to an infusion pump of the extracorporeal blood treatment system wherein the infusion lines of the extracorporeal blood treatment system comprise a pre-infusion line and a post-infusion line, the pre-infusion line connecting the infusion valve unit to the blood withdrawal line of the extracorporeal blood circuit and the post-infusion line connecting the infusion valve unit to the blood return line of the extracorporeal blood circuit, wherein the infusion valve unit comprises:
a first outlet coupled to the post-infusion line and a second outlet coupled to the pre-infusion line;
a one-way valve configured to allow infusion liquid to flow from an inlet towards at least one of the first and second outlets and to block fluid flow towards the inlet:
an infusion valve unit body delimiting an input chamber in fluid communication with the inlet and an output chamber in fluid communication with the first outlet and the second outlet, wherein the input chamber and the output chamber are separated from each other within the infusion valve unit body by a seal, the infusion valve unit body being made of rigid material, the stiffness of the rigid material of the valve unit being such to support the post-infusion line and the pre-infusion line without deforming the infusion valve unit body, the first outlet and the second outlet being each defined by tubular portions of the rigid material projecting outward from an outer surface of the infusion valve unit body.

US Pat. No. 10,589,016

TREATMENT SYSTEM WITH INFUSION APPARATUS PRESSURE PRIMING

Gambro Lundia AB, Lund (...

1. A blood treatment system comprising:a blood pump;
a filter, wherein access and return blood lines are in fluid communication with the filter;
an infusion line configured to be connected in fluid communication to one of the access blood line, the return blood line, and a patient;
an infusion apparatus controllable to provide a fluid flow from a replaceable fluid dispenser at a set flow rate, wherein the fluid flow comprises a plurality of boluses, and further wherein the infusion apparatus comprises an actuator configured to operate on the replaceable fluid dispenser to provide one bolus of the plurality of boluses into the infusion line when commanded; and
a controller configured to:
determine, upon connection of a replacement fluid dispenser in the infusion apparatus, if the infusion apparatus is being prevented when commanded from delivering one or more boluses to one of the access blood line, the return blood line, and the patient, and
prime the pressure in the replacement fluid dispenser if it is determined that the infusion apparatus is being prevented from delivering one or more boluses to one of the access blood line, the return blood line, and the patient, wherein the controller is configured to prime the pressure in the replacement fluid dispenser by accelerating one or more commands to the infusion apparatus to deliver one or more boluses into the infusion line so that pressure in the replacement fluid dispenser increases and a time required to deliver boluses to one of the access blood line, the return blood line, and the patient is decreased, wherein a time interval between an accelerated command and a prior command immediately preceding the accelerated command is less than a time interval between commands provided to deliver boluses at the set flow rate.

US Pat. No. 10,493,197

BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT

GAMBRO LUNDIA AB, Lund (...

1. A blood treatment apparatus comprising:a blood treatment unit,
a blood line configured to extract blood from a blood source, pass the blood through the blood treatment unit and deliver treated blood to a target vessel,
a fluid line configured to extract an electrically conductive treatment fluid from a fluid source, pass the electrically conductive treatment fluid through the blood treatment unit such that the electrically conductive treatment fluid can treat the blood within the blood treatment unit, and deliver used treatment fluid to a fluid sink,
a flow divider arranged in the fluid line, the flow divider separating the electrically conductive treatment fluid in the fluid line into a first fluid section and a second fluid section, wherein the first fluid section is electrically isolated from the second fluid section by the flow divider, limiting electrical current flowing in the fluid line between the first and second fluid sections, and
a control unit programmed to verify whether an electrical current flows between the first and second fluid sections by determining a value of the electrical current flowing between the first and second fluid sections, and if the value exceeds a predetermined value, indicate that the flow divider is not providing a desired electrical isolation.

US Pat. No. 10,463,779

MULTIPART FLUID SYSTEM AND A SYSTEM FOR REGIONAL CITRATE ANTICOAGULATION WITH A PHOSPHATE COMPRISING ANTICOAGULATION FLUID

GAMBRO LUNDIA AB, Lund (...

1. A multipart fluid system for dialysis therapy, said multipart fluid system comprising:an anticoagulation fluid; and
at least one treatment fluid from the group consisting of dialysis fluid and infusion fluids,
wherein the anticoagulation fluid comprises 10-40 mM citrate, and 0.1-2.0 mM phosphate,
wherein the at least one treatment fluid comprises 0-5 mM total calcium, 0-8 mM citrate, and 0.1-2.0 mM phosphate, and
wherein a concentration of the phosphate in the anticoagulation fluid is equivalent to the concentration of the phosphate in the at least one treatment fluid,
with provisos that
the at least one treatment fluid comprises citrate when total calcium concentration is 0 mM; and
the at least one treatment fluid comprises calcium when the citrate concentration is 0 mM.

US Pat. No. 10,342,911

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment, comprising:at least one treatment unit having at least one first chamber and at least one second chamber which are separated from one another by a semipermeable membrane;
at least one blood removal line connected with an inlet port of the first chamber and predisposed to remove blood from a patient;
at least one blood return line connected to an outlet port of the first chamber and predisposed to return treated blood to the patient;
at least one infusion line for providing replacement fluid, the at least one infusion line connected to one of said at least one blood removal line and said at least one blood return line;
at least one fluid evacuation line connected to an outlet port of the second chamber configured to receive at least one fluid filtered across the semipermeable membrane;
a regulating device of a transmembrane pressure between the first chamber and the second chamber of the treatment unit, the regulating device being active on at least one of: said at least one blood removal line, said at least one blood return line, said at least one infusion line, and said at least one fluid evacuation line; and
a control unit connected with the regulating device and configured to perform a setting sequence of the transmembrane pressure, the setting sequence comprising:
a) commanding the regulating device to impose a first increase (?TMP1) at a first value of the transmembrane pressure (TMP1) and reach a second transmembrane pressure (TMP2);
b) determining a value of a control parameter (?1) corresponding to the first increase in transmembrane pressure, wherein the control parameter comprises a variation between a replacement flow in the at least one infusion line at the first transmembrane pressure value (TMP1) and a replacement flow in the at least one infusion line at the second transmembrane pressure (TMP2);
c) comparing the value of the control parameter (?1) corresponding to the first increase in transmembrane pressure with a reference value (?ref);
d) determining if the value of the control parameter (?1) corresponding to the first increase in transmembrane pressure is greater than the reference value (?ref); and
e) if the value of the control parameter (?1) corresponding to the first increase in transmembrane pressure is greater than the reference value (?ref), commanding the regulating device to impose a second increase (?TMP2) on the transmembrane pressure which is greater than the first increase (?TMP1) and reach a third value of the transmembrane pressure (TMP3).

US Pat. No. 10,328,193

EXTRACORPOREAL BLOOD TREATMENT APPARATUS WITH MULTIPLE TREATMENT SOLUTION RESERVOIRS

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising:a filter comprising a primary chamber and a secondary chamber separated from the primary chamber by a semi-permeable membrane;
a blood circuit that includes an arterial line configured to deliver blood from a patient to the primary chamber and a venous line configured to remove the blood from the primary chamber and return the blood to the patient; and
a treatment solution delivery system configured to deliver treatment solution within the blood treatment apparatus through a treatment solution port, wherein the treatment solution delivery system comprises:
a plurality of treatment solution reservoirs, wherein each treatment solution reservoir of the plurality of treatment solution reservoirs comprises an outlet, wherein each treatment solution reservoir of the plurality of treatment solution reservoirs contains the same treatment solution;
a tubing set comprising a junction, a plurality of feeder lines connected to the junction, and an outlet line connected to the junction, wherein each feeder line is attached to one treatment solution reservoir of the plurality of treatment solution reservoirs, the tubing set configured to deliver treatment solution from the plurality of treatment solution reservoirs to the outlet line through the junction;
a reservoir status monitor configured to determine when a treatment solution reservoir of the plurality of treatment solution reservoirs requires replacement, wherein the reservoir status monitor comprises a gravimetric scale configured to measure the combined weight of the plurality of treatment solution reservoirs at the same time;
a plurality of a liquid-gas separation filters, wherein liquid-gas separation filter of the plurality of liquid-gas separation filters is positioned in each feeder line of the plurality of feeder lines of the tubing set, wherein each liquid-gas separation filter along each feeder line is located between the junction in the tubing set and the treatment solution reservoir to which the feeder line is attached, wherein all treatment solution passing through the outlet line passes through at least one liquid-gas separation filter, wherein each of the plurality of liquid-gas separation filters comprises a hydrophilic membrane through which the treatment solution passes;
an output flow controller operatively connected to the outlet line and having a first operating mode and a second operating mode, wherein the output flow controller delivers treatment solution from the plurality of treatment solution reservoirs to the treatment solution port in the first operating mode, wherein the plurality of treatment solution reservoirs are in simultaneous fluid communication with the junction of the tubing set through the plurality of feeder lines such that the plurality of treatment solution reservoirs empty simultaneously as the treatment solution flows through the outlet line to the output flow controller; and
a control unit operably connected to the output flow controller, wherein the control unit is configured to selectively operate the output flow controller in the first operating mode to deliver treatment solution from the plurality of treatment solution reservoirs to the treatment solution port.

US Pat. No. 10,543,309

TREATMENT SYSTEM WITH INFUSION APPARATUS PRESSURE PRIMING

Gambro Lundia AB, Lund (...

1. A blood treatment system comprising:a blood pump;
a filter, wherein access and return blood lines are in fluid communication with the filter;
an infusion line configured to be connected in fluid communication to one of the access blood line, the return blood line, and a patient;
an infusion apparatus controllable to provide a fluid flow from a replaceable fluid dispenser at a set flow rate, wherein the fluid flow comprises a plurality of boluses, and further wherein the infusion apparatus comprises an actuator configured to operate on the replaceable fluid dispenser to provide one bolus of the plurality of boluses into the infusion line when commanded; and
a controller configured to:
determine, upon connection of a replacement fluid dispenser in the infusion apparatus, if the infusion apparatus is being prevented when commanded from delivering one or more boluses to one of the access blood line, the return blood line, and the patient, and
prime the pressure in the replacement fluid dispenser if it is determined that the infusion apparatus is being prevented from delivering one or more boluses to one of the access blood line, the return blood line, and the patient, wherein the controller is configured to prime the pressure in the replacement fluid dispenser by accelerating one or more commands to the infusion apparatus to deliver one or more boluses into the infusion line so that pressure in the replacement fluid dispenser increases and a time required to deliver boluses to one of the access blood line, the return blood line, and the patient is decreased, wherein a time interval between an accelerated command and a prior command immediately preceding the accelerated command is less than a time interval between commands provided to deliver boluses at the set flow rate.

US Pat. No. 10,441,701

MEDICAL APPARATUS FOR THE PREPARATION OF MEDICAL FLUID

Gambro Lundia AB, Lund (...

1. A medical apparatus for the preparation of medical fluid, comprising:a support structure;
a movable member, movably mounted to the support structure and carrying a first port;
a first fluid line carried by the support structure and configured to be put into fluid communication with a source of fluid, the first fluid line being in fluid communication with the first port;
a second fluid line carried by the support structure and being in fluid communication with a second port;
biasing means; and
locking means;
wherein the first port is configured to receive a first connection port of a container of at least one substance to be added to a fluid coming from the source of fluid;
wherein the movable member is configured to move between at least a retracted configuration, in which the first port and the second port are coupled to each other, and an unretracted configuration, in which the first port and the second port are spaced apart from each other;
wherein the locking means is configured to releasably hold the movable member in its retracted configuration when in a locked configuration;
wherein the biasing means is configured to operate in at least one of a repulsion mode and an attraction mode,
wherein in the repulsion mode, the biasing means exerts on the movable member, at least when the locking means release the movable member from its retracted configuration, a biasing force directing the movable member away from its retracted configuration, and
wherein in the attraction mode, the biasing means exerts on the movable member, at least when the movable member is in its unretracted configuration, a biasing force directing the movable member towards its retracted configuration.

US Pat. No. 10,369,523

THERMOFORMING OF FIBER BUNDLES

Gambro Lundia AB, Lund (...

1. A process for the production of a capillary dialyzer comprising a bundle of hollow fiber membranes disposed within a tubular casing, the process comprising the steps of:shaping an end of the bundle of hollow fiber membranes to have a circular cross-section; and
compacting and melting together the fibers on the perimeter of the bundle of hollow fiber membranes to form a contiguous annular zone on the perimeter of the end of the bundle of hollow fiber membranes.

US Pat. No. 10,709,833

MULTIPART FLUID SYSTEM AND A SYSTEM FOR REGIONAL CITRATE ANTICOAGULATION IN AN EXTRACORPOREAL BLOOD CIRCUIT

Gambro Lundia AB, Lund (...

1. A system for regional citrate anticoagulation in an extracorporeal blood circuit comprising:an arterial blood line configured to be connected to a vascular access for withdrawing blood from a patient;
a venous blood line configured to be connected to the vascular access for returning blood to the patient;
a pump configured to be coupled to the arterial blood line or the venous blood line and move blood simultaneously through both the arterial blood line and the venous blood line;
a filter with a dialysate side and a blood side, wherein the blood side is in fluid communication with the arterial and venous blood lines;
a pre-filter infusion line connected to the arterial blood line upstream the filter and connected to an anticoagulation fluid source containing at least 8 mM citrate to be infused into the blood stream in the arterial blood line, and
a post-filter infusion line connected to the venous blood line downstream the filter and connected to an infusion fluid source comprising 2-8 mM citrate and 1-5 mM total calcium to be infused into the blood stream in the venous blood line.

US Pat. No. 10,569,005

DEVICE AND METHOD FOR DISRUPTION DETECTION

Gambro Lundia AB, Lund (...

1. A monitoring device for detecting a disruption of a fluid connection between a first fluid containing system comprising a first pulse generator and a second fluid containing system comprising a second pulse generator, said monitoring device comprising:an input for receiving at least one pressure signal from a set of pressure sensors arranged in the first fluid containing system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator; and
a signal processor connected to the input and being configured to:
populate a plurality of signal vectors of identical length such that each of the signal vectors corresponds to a respective signal segment of signal values in the at least one pressure signal;
process the signal vectors by a source separation algorithm so as to compute one or more eigenvector and/or one or more eigenvalue associated with the signal vectors; and
detect the disruption based on a monitoring parameter, which is computed as a function of the one or more eigenvector and/or the one or more eigenvalue to be responsive to the second pulses in the at least one pressure signal.

US Pat. No. 10,661,228

CONTACT-FREE THERMOFORMING OF FIBER BUNDLES

Gambro Lundia AB, Lund (...

1. A process for the production of a capillary dialyzer comprising a bundle of hollow fiber membranes disposed within a tubular casing, the process comprising, prior to transfer of the bundle of hollow fiber membranes into the tubular casing, forming a contiguous annular zone on a perimeter of a first end of a bundle of hollow fiber membranes by melting together the fibers on the perimeter of the bundle of hollow fiber membranes while the fibers within the area of the bundle end face framed by the contiguous annular zone remain unchanged, wherein the melting is effected by irradiation.

US Pat. No. 10,625,014

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND METHOD OF CONTROL OF A BLOOD-WARMING DEVICE IN AN EXTRACORPOREAL BLOOD TREATMENT APPARATUS

GAMBRO LUNDIA AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising:a holding portion configured for receiving an extracorporeal blood circuit having a treatment unit, a blood withdrawal line connected to a blood inlet of the treatment unit, and a blood return line connected to an outlet of the treatment unit;
a blood pump which, when the extracorporeal blood circuit is received by the holding portion, is configured for controlling the flow of blood flowing through at least one of said blood withdrawal line and blood return line;
at least one treatment fluid source;
at least one treatment fluid line in fluid communication with the at least one treatment fluid source and in direct or indirect fluid communication with said extracorporeal blood circuit to supply treatment fluid to the extracorporeal blood circuit; and
a control unit connectable with a blood warming device having heating components, the control unit being configured to execute a control procedure for the blood warming device to heat and maintain at least a portion of the extracorporeal blood circuit within a desired temperature boundary, wherein the control procedure includes:
establishing a communication with said blood warming device,
identifying, among a plurality of modes of operation of the apparatus, a current operational mode which the apparatus is performing,
calculating an electric power maximum threshold allowed to be supplied to the heating components of the blood-warming device, wherein the power maximum threshold is calculated based at least on measured or set flow rates of the treatment fluid from the at least one treatment fluid source in said at least one treatment fluid line, and
generating a control signal for the blood warming device based on the calculated electric power maximum threshold, the control signal comprising at least one of the following:
a command directed to impose to the blood warming device a mode of operation and an amount of electric power to be supplied to the heating components of the blood warming device depending upon the identified current operational mode of said apparatus; or
an information defining said identified current operational mode.

US Pat. No. 10,507,279

CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment, comprising:an extracorporeal blood circuit and a connection system configured to connect the extracorporeal blood circuit to the vascular system of a patient, the extracorporeal blood circuit comprising a blood processing device;
at least one pressure sensor configured to sense pressure pulses from a physiological pulse generator in the patient;
at least one pumping device; and
a control system configured to switch between a pre-treatment mode and a blood treatment mode, the control system configured in the blood treatment mode to operate the at least one pumping device to pump blood from the vascular system via the connection system through the blood processing device and back to the vascular system via the connection system, the control system comprising:
a sensor signal input device to obtain measurement data from the at least one pressure sensor configured to sense pressure pulses from a physiological pulse generator in the patient, wherein the measurement data comprises a measurement signal from the at least one pressure sensor; and
a signal processor connected to the sensor signal input device and being configured to, in the pre-treatment mode and post-priming prior to blood treatment, process the measurement data to detect connection of the extracorporeal blood circuit to the vascular system of the patient, wherein the connection is configured to be detected by the control system identifying a characteristic change in the measurement data indicating the connection of the extracorporeal blood circuit to the vascular system of the patient, and, upon such identification of the characteristic change, the control system is configured to take a dedicated action to control operation of the apparatus, the dedicated action comprising enabling the apparatus to enter into the blood treatment mode by operating the at least one pumping device upon identification of the characteristic change in the measurement signal.

US Pat. No. 10,610,628

DIALYSIS MONITORS, METHODS RELATING TO HEATING OF FLUIDS, AND USE OF BATTERY UNITS OF DIALYSIS MONITORS

GAMBRO LUNDIA AB, Lund (...

1. A dialysis monitor for performing dialysis treatment on a patient, said dialysis monitor comprising:a treatment fluid path configured to provide treatment fluid to a dialyzer when dialysis treatment is performed by the dialysis monitor;
a heater configured to heat fluid present in the treatment fluid path;
a battery unit configured to provide back-up power to at least a portion of the dialysis monitor during treatment should a supply of external power be discontinued;
a first switch connected between the battery unit and the heater, said first switch having a first state where energy is supplied from the battery unit to the heater and a second state where energy is prevented from being supplied from the battery unit to the heater; and
a controller programmed
(i) to use the battery unit to provide back-up power to at least the portion of the dialysis monitor should the supply of external power be discontinued during treatment, and wherein the controller is further programmed such that during discontinued external power (a) treatment fluid flowing through the dialyzer is stopped while blood flows through the dialyzer, or (b) at least one pump is stopped and at least one extracorporeal blood transport line is clamped to prevent blood from being extracted from the patient; and
(ii) to control a state of said first switch and to set the state of said first switch to said first state, thereby supplying energy from the battery unit to the heater, at a time when dialysis treatment is not being performed on the patient by the dialysis monitor.

US Pat. No. 10,478,076

MONITORING A PROPERTY OF THE CARDIOVASCULAR SYSTEM OF A SUBJECT

Gambro Lundia AB, Lund (...

29. A method for monitoring a cardiovascular property of a mammalian subject, said method comprising:obtaining, via a processor, measurement data from a primary pressure wave sensor which is arranged to detect pressure waves in an extracorporeal fluid circuit which is in fluid communication with the cardiovascular system of the subject, the extracorporeal fluid circuit including a venous line and an arterial line;
generating, via the processor, a time-dependent monitoring signal based on the measurement data, such that the monitoring signal comprises a sequence of heart pulses, wherein each heart pulse represents a pressure wave originating from a heart beat in the subject;
determining, via the processor, beat classification data for each heart pulse in the monitoring signal, the beat classification data including information sufficient to distinguish between heart pulses originating from normal heart beats and heart pulses originating from ectopic heart beats;
forming a classification of at least one heart pulse of the sequence of heart pulses using the beat classification data, the classification based on (i) the at least one heart pulse represented as a cluster of shape features, and (ii) distances of the at least one heart pulse cluster of shape features from a plurality of clusters of shaped features of other heart pulses, wherein each cluster is in an N-dimensional space, and wherein N represents a number of shape features for each heart pulse;
calculating, via the processor, based at least partly on the classification of the at least one heart pulse, a parameter value indicative of the cardiovascular property; and
at least one of (i) causing the calculated parameter value to be displayed, or (ii) generating an alarm based on the calculated parameter value.

US Pat. No. 10,398,827

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND METHOD OF CONTROL OF A BLOOD-WARMING DEVICE IN AN EXTRACORPOREAL BLOOD TREATMENT APPARATUS

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus, comprising:an extracorporeal blood circuit having a treatment unit, a blood withdrawal line connected to a blood inlet of the treatment unit, and a blood return line connected to a blood outlet of the treatment unit;
a blood pump configured for controlling blood flow rate flowing through at least one of said blood withdrawal line and blood return line;
an infusion line connected to the extracorporeal blood circuit, wherein the infusion line is connected to the extracorporeal blood circuit at a junction point positioned downstream of a blood heating zone;
a control unit configured to execute the following procedure:
receive a first value representative of a desired blood temperature at an end of the blood return line, wherein the end of the blood return line is configured to be connected to a venous vascular access of a patient;
receive a first signal relating to a flow rate of an infusion fluid in said infusion line;
calculate a set point of an operating parameter to be imposed on a warming device configured to heat the blood heating zone of the extracorporeal blood circuit in order to maintain said desired blood temperature at said end of the blood return line;
wherein the set point is calculated based on input parameters comprising:
at least the first value representative of the desired blood temperature, and
at least one of:
the first signal, and
a second value representative of a temperature of said infusion fluid in said infusion line.

US Pat. No. 10,325,680

USER INTERFACE FOR AN EXTRACORPOREAL BLOOD TREATMENT MACHINE

Gambro Lundia AB, Lund (...

1. A machine for extracorporeal blood treatment comprising:a machine body;
a blood pump actuator located on the machine body;
a blood pumping module including a rigid support element configured to be mated with the blood pump actuator located on the machine body, and blood tubing supported by the rigid support element;
a touch screen user interface including a first area displaying
at a first time a first screen including (i) at least part of the machine body, (ii) a depiction of at least part of the touch screen and (iii) at least part of the blood pumping module located adjacent to the depiction of the at least part of the touch screen and a second area displaying first text associated with a first setup procedure concerning installation of the blood pumping module onto the machine body; and
at a second time a second screen in place of the first screen, the second screen including (i) at least part of the machine body, (ii) a depiction of at least part of the touch screen and (iii) at least part of the blood pumping module located adjacent to the depiction of the at least part of the touch screen and a second area displaying second text associated with a second setup procedure concerning installation of the blood pumping module onto the machine body; and
a control unit programmed to accept a first user input to cause a first portion of at least one of the at least part of the machine body or the at least part of the blood pumping module displayed on the touch screen user interface and associated with the first text to be highlighted and to accept a second user input to cause a second portion of at least one of the at least part of the machine body or the at least part of the blood pumping module displayed on the touch screen user interface and associated with the second text to be highlighted.

US Pat. No. 10,668,199

MEDICAL APPARATUS FOR EXTRACORPOREAL TREATMENT OF FLUID AND A PROCESS OF CALCULATING SET FLOW RATES IN A MEDICAL APPARATUS FOR DELIVERY OR COLLECTION OF FLUIDS

Gambro Lundia AB, Lund (...

1. A method for extracorporeal treatment of fluid using an apparatus comprising:a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;
a blood withdrawal line connected to an inlet of the primary chamber, and a blood return line connected to an outlet of the primary chamber, the blood lines being configured for connection to a patient cardiovascular system;
a blood pump configured to control the flow of blood through the blood lines; an effluent fluid line connected, at one end thereof, to an outlet of the secondary chamber and at its other end to a waste container, wherein effluent fluid flowing through the effluent fluid line comprises an effluent fluid flow rate (Qeff);
the method comprising:
connecting at least two fluid lines within the apparatus, wherein the at least two fluid lines are selected from the group of fluid lines comprising:a pre-dilution infusion fluid line connected at one end thereof to the blood withdrawal line and at its other end to a first container of fresh fluid, wherein pre-dilution fluid flowing through the pre-dilution infusion fluid line comprises a pre-dilution infusion fluid flow rate Qrep1,a post-dilution infusion fluid line connected at one end thereof to the blood return line and at its other end to a second container of fresh fluid, wherein post-dilution fluid flowing through the post-dilution infusion fluid line comprises a post-dilution infusion fluid flow rate Qrep2,a dialysis liquid fluid line connected at one end thereof to an inlet of the secondary chamber and at its other end to a third container of fresh fluid, wherein dialysis liquid flowing through the dialysis liquid fluid line comprises a dialysis liquid fluid flow rate Qdial, anda pre-blood pump infusion fluid line connected at one end thereof to a fourth container of fresh fluid and at its other end to the blood withdrawal line in a region of the blood withdrawal line which is positioned in use upstream the blood pump, wherein pre-blood pump infusion fluid flowing through the pre-blood pump infusion fluid line comprises a pre-blood pump infusion fluid flow rate Qpbp;calculating set values (Qiset) of the fluid flow rates of the at least two fluid lines such that:an emptying time of each container of fresh fluid connected at the other end of the at least two fluid lines and a filling time of the waste container are multiples of a same reference time (Tr); anda sum of the set values (Qiset) of the fluid flow rates through the at least two fluid lines and of a patient fluid removal rate (Qpfr) is equal to the effluent fluid flow rate (Qeff);wherein, when connecting the at least two fluid lines comprises connecting the pre-dilution infusion fluid line to the first container, one set value (Qiset) comprises the pre-dilution infusion fluid flow rate Qrep1 and the method comprises regulating pre-dilution infusion fluid flow through the pre-dilution infusion fluid line such that an emptying time of the first container of fresh fluid and the filling time of the waste container are multiples of the same reference time (Tr);wherein, when connecting the at least two fluid lines comprises connecting the post-dilution infusion fluid line to the second container, one set value (Qiset) comprises the post-dilution infusion fluid flow rate Qrep2 and the method comprises regulating post-dilution infusion fluid flow through the post-dilution infusion fluid line such that an emptying time of the second container of fresh fluid and the filling time of the waste container are multiples of the same reference time (Tr);wherein, when connecting the at least two fluid lines comprises connecting the dialysis liquid infusion fluid line to the third container, one set value (Qiset) comprises the dialysis liquid fluid flow rate Qdial and the method comprises regulating dialysis liquid flow through the dialysis liquid fluid line such that an emptying time of the third container of fresh fluid and the filling time of the waste container are multiples of the same reference time (Tr); andwherein, when connecting the at least two fluid lines comprises connecting the pre-dilution infusion fluid line to the fourth container, one set value (Qiset) comprises the pre-blood pump infusion fluid flow rate Qpbp and the method comprises regulating pre-dilution infusion fluid flow through the pre-blood pump infusion fluid line such that an emptying time of the fourth container of fresh fluid and the filling time of the waste container are multiples of the same reference time (Tr).

US Pat. No. 10,661,230

HEMODIALYZER FOR BLOOD PURIFICATION

GAMBRO LUNDIA AB, Lund (...

1. A hemodialyzer for the purification of blood comprising a bundle of hollow fiber membranes prepared from a solution comprising 10 to 20 wt.-% of at least one hydrophobic polymer component, 2 to 11 wt.-% of at least one hydrophilic polymer component, and at least one solvent, wherein the membranes have a molecular retention onset (MWRO) of between 9.0 kDa and 14.0 kDa and a molecular weight cut-off (MWCO) of between 55 kDa and 130 kDa as determined by dextran sieving before blood contact of the membrane,wherein the inner diameter of the membrane is below 200 ?m and the wall thickness of the membrane is below 40 ?m.

US Pat. No. 10,646,632

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

GAMBRO LUNDIA AB, Lund (...

1. An apparatus for extracorporeal blood treatment comprising:a filtration unit having a primary chamber and a secondary chamber separated by a semi-permeable membrane;
a blood withdrawal line in fluid communication with an inlet of the primary chamber;
a blood return line in fluid communication with an outlet of the primary chamber, the blood lines configured for connection to a patient cardiovascular system;
a dialysis supply line in fluid communication with an inlet of the secondary chamber;
a dialysis effluent line in fluid communication with an outlet of the secondary chamber;
a preparation device for preparing dialysis fluid, the preparation device in fluid communication with the dialysis supply line and comprising a regulating device for regulating composition of the dialysis fluid;
a sensor for measuring a parameter value of dialysate in the dialysis effluent line, the parameter value of the dialysate being at least one chosen from a group consisting of: (i) conductivity of the dialysate; (ii) a conductivity-related parameter of the dialysate; (iii) concentration of at least a substance in the dialysate; or (iv) a concentration-related parameter of at least a substance in the dialysate; and
a control unit communicating with the sensor to receive the parameter value of the dialysate, the control unit further communicating with the regulating device and calculating a value representative of plasma conductivity, wherein the control unit is configured for:
setting a parameter value for dialysis fluid in the dialysis supply line at an initial set point, the parameter value of the dialysis fluid being at least one chosen from a group consisting of: (i) conductivity of the dialysis fluid; (ii) a conductivity-related parameter of the dialysis fluid; (iii) concentration of at least a substance in the dialysis fluid; or (iv) a concentration-related parameter of at least a substance in the dialysis fluid;
after setting the parameter value of the dialysis fluid at the initial set point, circulating the dialysis fluid through the secondary chamber of the filtration unit so as to exchange with blood;
circulating blood through the primary chamber of the filtration unit;
measuring at least an initial parameter value of the dialysate downstream of the secondary chamber at the beginning of the treatment; and
calculating, based on the measured initial value and on a corresponding parameter value of the dialysis fluid in the dialysis supply line, an initial plasma conductivity,
wherein the circulating of the dialysis fluid through the secondary chamber up to the measuring of the initial value used for calculating the initial plasma conductivity is performed while maintaining the parameter value of the dialysis fluid to be substantially constant.

US Pat. No. 10,569,007

DIALYSIS SYSTEM AND METHOD INCLUDING A FLOW PATH INSULATOR

GAMBRO LUNDIA AB, Lund (...

1. A renal failure therapy system comprising:a dialyzer;
a blood circuit including a blood pump in fluid communication with the dialyzer;
a dialysis circuit in fluid communication with the dialyzer; and
at least one flow path insulator located in the dialysis circuit or the blood circuit, the flow path insulator including (i) a structure that separates liquid flowing within the flow path insulator into a plurality of separated liquid segments that create electrical isolation within the flow path insulator, and (ii) an air isolation chamber that is separated by at least one baffle from a lower chamber that receives the liquid segments to keep the air isolation chamber dry.

US Pat. No. 10,563,646

PERISTALTIC PUMP TUBE

Gambro Lundia AB, Lund (...

1. A tube for a peristaltic pump, comprising:an elastically deformable tubular body, made of a material containing at least a vinyl chloride resin and at least a plasticizer comprising a derivative of adipic acid, the resin having a K value of more than 100 and no more than 105 measured according to standard ISO 1628-2, and the tubular body being made entirely of a single layer of the material.
US Pat. No. 10,420,797

ANTICOAGULATION FLUID COMPRISING CITRATE AND PHOSPHATE

Gambro Lundia AB, Lund (...

1. A single compartment bag comprising an anticoagulation fluid for regional citrate anticoagulation in an extracorporeal blood circuit, wherein the anticoagulation fluid in the single compartment bag comprises:18-40 mM basic citrate;
0-5 mM acid citrate;
0.1-3 mM phosphate; and
1.5-4 mM calcium, the anticoagulation fluid having a pH between 7.4 and 8.
US Pat. No. 10,675,594

ACRYLONITRILE-BASED MEMBRANE WITH LOW THROMBOGENICITY

Gambro Lundia AB, Lund (...

1. A membrane comprising a copolymer of acrylonitrile and sodium methallylsulfonate, a polycationic polymer, and a zwitterionic compound,wherein the polycationic polymer is polyethyleneimine (PEI),
wherein the zwitterionic compound is a sulfobetaine, and
wherein the PEI and the sulfobetaine are ionically grafted on the membrane at a weight ratio in the range of from 1:5 to 1:20 (PEI:sulfobetaine).

US Pat. No. 10,603,392

DIALYSIS MONITORS AND METHODS OF OPERATION

GAMBRO LUNDIA AB, Lund (...

1. A dialysis monitor configured to be coupled to a disposable extracorporeal blood circuit, the dialysis monitor comprising:an inlet configured for receiving purified water from a water supply system located external to the dialysis monitor;
a treatment fluid path configured to provide treatment fluid at a first temperature to a dialyzer while dialysis treatment is being performed, wherein the treatment fluid path includes an inlet valve connected to the inlet;
a tank located within the dialysis monitor and connected to the treatment fluid path, the tank configured to hold a fluid having a temperature higher than said first temperature; and
a controller programmed to (i) arrange that said tank holds said fluid having said higher temperature at least for a period of time when said treatment fluid path is supplying treatment fluid at said first temperature during the dialysis treatment, (ii) cause the fluid held in the tank to be discharged at a time when dialysis treatment is not being performed in order to perform thermal disinfection of at least a portion of said treatment fluid path, and (iii) set the inlet valve in a fluidly closed state at the time of the thermal disinfection.

US Pat. No. 10,625,013

DETECTION OF A DISRUPTION OF A FLUID CONNECTION BETWEEN TWO FLUID CONTAINING SYSTEMS

GAMBRO LUNDIA AB, Lund (...

1. A monitoring device, comprising:a disruption detector configured to obtain a measurement signal, which is generated by a sensor arranged in or associated with a first fluid containing system and is responsive to a disruption of a fluid connection between the first fluid containing system and a second fluid containing system, the disruption detector being further configured to operate on the measurement signal to detect an apparent disruption of the fluid connection and generate an alarm indication corresponding to the apparent disruption;
an alarm module for activating an alarm based on the alarm indication;
a false alarm analyzer configured to produce a count of false alarm indications generated per unit time by the disruption detector for one or more configurations of the disruption detector; and
an updater configured to update the configuration of the disruption detector based on the count.

US Pat. No. 10,583,279

DIALYSIS APPARATUS WITH VERSATILE USER INTERFACE AND METHOD AND COMPUTER PROGRAM THEREFOR

Gambro Lundia AB, Lund (...

1. An apparatus for performing a plurality of operation steps of a dialysis process, said apparatus comprising:a process controller for controlling the apparatus to perform the operation steps of the dialysis process, monitor process progress of the dialysis process and monitor sensor inputs from sensors of the apparatus; and
a user interface (“UI”) comprising a display, an input device and a UI controller, wherein the UI controller is configured to enable presentation of graphical data on the display, and wherein the UI controller is configured to enable user interaction with the graphical data and is configured to exchange information with the process controller, wherein the exchanged information is based on the user interaction via the user interface and the process progress of the dialysis process and sensor inputs from the sensors monitored by the process controller, wherein
the UI controller is configured to represent each of the operation steps by one or more operation step items, each of which is a graphical item suitable to be presented on said display and is selectable by an operator if its corresponding operation step is available, and wherein an amount of operation guidance information of an operation step item is selectable by the operator during the dialysis process to be in one guidance state among a set of guidance states comprising at least a first and a second guidance state, wherein the second guidance state provides a larger amount of guidance than the first guidance state by assigning additional operation guidance information of one or more operation step item selectable for multiple operation steps of the dialysis process, wherein the UI controller maintains the second guidance state over multiple operation steps of the dialysis process while the second guidance state is selected, and wherein the operator is enabled to toggle between the guidance states during the dialysis process,
wherein at least one of the operation step items includes operation substep items that represent substeps of the at least one operation step by at least one of operation guidance, parameter setting and status information, wherein the UI controller is arranged to enable display of the operation substep items upon display of the corresponding operation step item when in another guidance state than the first guidance state, and
wherein the UI controller is arranged to enable display of a subset of the operation substep items upon display of the corresponding operation step item associated with the subset of operation substep items based on an input from the operator when in the second guidance state, wherein such enabling based on input from the operator overrides any corresponding disabling of the display of the operation substep items by the UI controller when in the first guidance state.

US Pat. No. 10,661,231

MEMBRANE FOR BLOOD PURIFICATION

GAMBRO LUNDIA AB, Lund (...

1. A semipermeable membrane prepared from a polymer solution comprising 10 to 20 wt.-% of at least one hydrophobic polymer component, 5 to 10 wt.-% of at least one hydrophilic polymer component and at least one solvent, wherein the membrane has a molecular retention onset (MWRO) of between 9.0 kDa and 14.0 kDa and a molecular weight cut-off (MWCO) of between 55 kDa and 130 kDa as determined by dextran sieving before blood contact of the membrane, and wherein during production of the semipermeable membrane, said membrane is not treated with a salt solution before drying.

US Pat. No. 10,983,676

NORMAL WORKFLOW AND DEVIATIONS THEREFROM

Gambro Lundia AB, Lund (...

1. A medical treatment system comprising:treatment apparatus comprising one or more pumps and one or more sensors;
a display comprising a graphical user interface, wherein the graphical user interface is configured to display a plurality of process feature graphical elements related to preparing a treatment, performing a treatment, and performing post-treatment processes, wherein each process feature graphical element of the plurality of process feature graphical elements corresponds to a different process feature of the medical treatment system; and
a computing apparatus comprising one or more processors, wherein the computing apparatus is operatively coupled to the treatment apparatus and the display, wherein the computing apparatus is configured to:
display a plurality of process feature graphical elements on the graphical user interface to be used by a user to prepare a treatment, to perform a treatment, and to perform post-treatment processes, wherein the plurality of process feature graphical elements comprises at least one of a blood process feature graphical element corresponding to a blood circuit of the treatment apparatus, a dialysate process feature graphical element corresponding to a dialysate circuit of the treatment apparatus, an ultrafiltration process feature graphical element corresponding to one or more ultrafiltration processes, and a patient process feature graphical element representative of the patient and connection of the patient to a blood circuit of the treatment apparatus,
define a normal workflow comprising a plurality of steps for the preparation of a treatment, the performance of the treatment, and the performance of post-treatment processes,
display one or more of a plurality of workflow affordances on the graphical user interface to indicate to a user which of and how the plurality of process feature graphical elements are to be used to perform the plurality of steps of the normal workflow, and
display a workflow deviation affordance on the graphical user interface in response to a user deviating from the normal workflow, wherein the workflow deviation affordance indicates which of and how the plurality of process feature graphical elements are to be used to return to the normal workflow.

US Pat. No. 10,891,040

SYSTEMS AND METHODS INCLUDING BAR-TYPE PARAMETER ADJUSTMENT ELEMENTS

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment system comprising:extracorporeal blood treatment apparatus comprising one or more pumps, one or more sensors, and one or more disposable elements for use in performing an extracorporeal blood treatment;
a display comprising a graphical user interface configured to depict a parameter adjustment region corresponding to one or more parameters related to the extracorporeal blood treatment performable using the extracorporeal blood treatment apparatus; and
a processor operatively coupled to the extracorporeal blood treatment apparatus and the display and configured to:
provide one or more parameters related to the extracorporeal blood treatment performable using the extracorporeal blood treatment apparatus and one or more reference values, wherein each of the one or more reference values is associated with a different parameter of the one or more parameters, wherein each of the one or more reference values represents a selected prescription value, a preset default value, or a saved value for a patient for the associated parameter of the one or more parameters,
display the parameter adjustment region on the graphical user interface, wherein the parameter adjustment region comprises one or more bar-type parameter adjustment elements, wherein each of the one or more bar-type parameter adjustment elements is associated with and configured to adjust a different parameter of the one or more parameters related to the extracorporeal blood treatment performable using the extracorporeal blood treatment apparatus, wherein each of the one or more bar-type parameter adjustment elements comprises:
a bar element extending from a first end representative of a lower value for the associated parameter to a second end representative of an upper value for the associated parameter, and
an indicator element located along the bar element between the first end and the second end indicative of a present value of the associated parameter, wherein the indicator element is configurable in a locked state and an unlocked state, wherein the indicator element is unmovable along the bar element by selecting and dragging the indicator element when in the locked state, wherein the indicator element is movable along the bar element by selecting and dragging when in the unlocked state,
configure the indicator element of the one or more bar-type parameter adjustment elements in the locked state when the indicator element is not selected by a user,
configure the indicator element of the one or more bar-type parameter adjustment elements into the unlocked state in response to a user selecting and maintaining selection of the indicator element for an unlock time period, and
decrease or increase the parameter of the one or more parameters related to the extracorporeal blood treatment performable using the extracorporeal blood treatment apparatus associated with the bar-type parameter adjustment element of the one or more bar-type parameter adjustment elements in response a user moving the indicator element of the bar-type parameter adjustment element along the bar element towards the first end or the second end, respectively, when the indicator element is in the unlocked state.

US Pat. No. 10,881,779

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. A process of setting transmembrane pressure between a first chamber and a second chamber of a treatment unit in an apparatus for extracorporeal blood treatment,the apparatus comprising:
at least one blood removal line connected with an inlet port of the first chamber and predisposed to remove blood from a patient;
at least one blood return line connected to an outlet port of the first chamber and predisposed to return treated blood to the patient;
at least one infusion line for providing replacement fluid, the at least one infusion line connected to one of said at least one blood removal line and said at least one blood return line; and
at least one fluid evacuation line connected to an outlet port of the second chamber configured to receive at least one fluid filtered across the semipermeable membrane;
the treatment unit having the first chamber and the second chamber separated from one another by a semipermeable membrane, wherein a difference in pressures in the first chamber and the second chamber across the semipermeable membrane defines a transmembrane pressure;
the process comprising a setting sequence that comprises:
imposing a first increase in transmembrane pressure (?TMP1) on a first transmembrane pressure (TMP1) to reach a second transmembrane pressure (TMP2);
determining a value of a control parameter (?1) corresponding to the first increase in transmembrane pressure, wherein the control parameter is related to a variation between a replacement flow in the at least one infusion line at the first transmembrane pressure (TMP1) and a replacement flow in the at least one infusion line at the second transmembrane pressure (TMP2);
comparing the value of the control parameter (?1) corresponding to the first increase in transmembrane pressure (?TMP1) with a reference value (?ref);
determining if the value of the control parameter (?1) corresponding to the first increase in transmembrane pressure (?TMP1) is greater than the reference value (?ref); and
if the value of the control parameter (?1) corresponding to the first increase in transmembrane pressure (?TMP1) is greater than the reference value (?ref), imposing a second increase (?TMP2) on the transmembrane pressure which is greater than the first increase in transmembrane pressure (?TMP1) to reach a third transmembrane pressure (TMP3).
US Pat. No. 10,729,722

DIALYSIS SOLUTION, FORMULATED AND STORED IN TWO PARTS, COMPRISING PHOSPHATE

Gambro Lundia AB, Lund (...

1. A multi-compartment bag comprising a two-part medical solution comprising a first single solution and a second single solution,wherein said first single solution is sterile and comprises phosphate ions and bicarbonate, wherein said first single solution has a pH of 10.1-10.5, and wherein the first single solution does not comprise calcium or magnesium;
wherein said second single solution is sterile and comprises calcium, magnesium and HCl and has a pH of 1.0-1.5, and wherein the second single solution does not comprise phosphate ions;
wherein said first and second single solutions upon use are capable of being mixed together to form a ready-for-use medical solution, wherein the phosphate concentration is 1.0-2.8 mM, the bicarbonate concentration is 25-35 mM, and said medical solution is sterile and has a pH of 6.5-7.6; and
wherein within 24 hours of mixing the ready-for-use medical solution is stable and particles of 10 ?m are less than 25 counts/ml.

US Pat. No. 10,918,779

CLEANING OF BIOLOGICAL FLUID

Gambro Lundia AB, Lund (...

1. A system configured to remove deleterious substances from blood or separated blood plasma, the system comprising:a blood circuit;
a fluid circuit;
a cleaning fluid;
and
a blood treatment unit comprising one or more semipermeable membranes separating a fluid compartment from a blood compartment configured to mix blood, or separated blood plasma, and the cleaning fluid;
wherein the cleaning fluid comprises a displacer substance, and the displacer substance is a combination of sodium octanoate with one or both of sodium salicylate and sodium acetylsalicylate.

US Pat. No. 10,828,412

SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION INCLUDING MIXING AND HEATING THEREFORE

Gambro Lundia AB, Lund (...

1. A peritoneal dialysis system comprising:a cycler including a pump actuator, a heater and a heating pan operable with the heater, wherein the heating pan includes a sidewall forming a slot; and
a disposable set operable with the cycler, the disposable set including
a pumping cassette including a pump chamber configured to be actuated by the pump actuator, and
a heater/mixing container in fluid communication with the pumping cassette and sized to be received at the heating pan, the heater/mixing container including a port configured such that when the port is slid into the slot of the heater pan sidewall, the port is prevented from rotating about an axis transverse to a direction of flow through the port, wherein the slot includes an angled section through which a portion of the port is inserted and a circular section for receiving the portion of the port, and wherein a transition from the angled section to the circular section is sized so that the portion of the port press-fits through the transition to provide tactile feedback.

US Pat. No. 10,780,186

SYSTEM, APPARATUS, EQUIPMENT WITH THERMAL DISINFECTION AND THERMAL DISINFECTION METHODS

Gambro Lundia AB, Lund (...

1. A water system for providing water to at least one connected device through a fluid path and being able to disinfect the fluid path by means of thermal disinfection, the water system comprising:an inlet for receiving water to the water system;
a heating unit configured to heat water within the water system;
a filter unit configured to filter water within the water system in order to provide filtered water to an outlet;
an actuator configured to control the flow of the water from the heating unit to the outlet;
a fluid path connected to the outlet, the fluid path comprising at least one connector configured to connect to at least one device to which water is provided by the water system;
a temperature sensor configured to measure the temperature of the fluid in the fluid path; and
a control unit including a memory and connected to the heating unit, the actuator and the temperature sensor, the control unit configured to (i) start the disinfection of the fluid path by controlling the heating unit to heat water and controlling the actuator to enable heated water to flow to the outlet and further into the fluid path, (ii) read the temperature as measured by the temperature sensor during the disinfection, (iii) calculate an achieved disinfection dose based on the read temperature, (iv) compare the achieved disinfection dose with information representing a set disinfection dose, (v) discontinue the disinfection if the achieved disinfection dose equals or exceeds the set disinfection dose, and (vi) store information representing a time required for the achieved disinfection dose to equal or exceed the set disinfection dose in the memory during and/or after disinfection has been completed.

US Pat. No. 11,026,968

ANTICOAGULATION FLUID COMPRISING CITRATE AND PHOSPHATE

Gambro Lundia AB, Lund (...

1. A single compartment bag comprising an anticoagulation fluid for regional citrate anticoagulation in an extracorporeal blood circuit, wherein the anticoagulation fluid in the single compartment bag comprises 18-40 mM basic citrate; 0.1-5 mM acid citrate; 0.5-1.5 mM total calcium; and 0.1-3 mM phosphate, the anticoagulation fluid having a pH between 7.4 and 8.

US Pat. No. 11,007,309

EXTRACORPOREAL BLOOD TREATMENT APPARATUS AND METHOD OF SETTING AN EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An extracorporeal blood treatment apparatus comprising:a blood treatment unit having a primary chamber configured to receive blood of a patient to be treated, and a secondary chamber separated from the primary chamber by a semi-permeable membrane;
an hydraulic circuit having a fresh fluid line configured to connect to an inlet of the secondary chamber, and a spent fluid line configured to connect to an outlet of said secondary chamber and configured to remove spent liquid from the secondary chamber and convey it to at least one waste,
a control unit operably connected to the hydraulic circuit and configured to control the hydraulic circuit to selectively operate in a normal mode, where the fresh fluid line is connected to the inlet of the secondary chamber of the treatment unit and conveys fresh treatment liquid to the secondary chamber, and wherein the control unit is further configured to control the hydraulic circuit to selectively operate in an isolated ultrafiltration mode, where the fresh fluid line does not convey fresh treatment liquid to the secondary chamber,
the control unit further configured to execute a setup phase before starting treatment, the setup phase comprising:
receiving at least two general setup values selected from:
a prescription value for a total treatment time during which the patient is to be submitted to blood treatment,
a prescription value for a total patient fluid removal to be achieved by the end of total treatment time,
a prescription value for an average patient fluid removal rate to be kept across total treatment time;
receiving instructions to execute a selected plurality of isolated ultrafiltration tasks during the total treatment time, wherein the control unit is configured to:
receive, for each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks, values of at least two isolated ultrafiltration parameters selected from:
an isolated ultrafiltration time, which is a time interval during which the apparatus is requested to operate in said isolated ultrafiltration mode,
an isolated ultrafiltration volume, which is a volume of fluid to be removed from the patient while the apparatus is requested to operate in said isolated ultrafiltration mode,
an isolated ultrafiltration rate which is a rate of fluid removal from the patient while the apparatus is requested to operate in said isolated ultrafiltration mode;
determining, during the setup phase, at least one of:
a remaining treatment time based on said isolated ultrafiltration time of each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks, the remaining treatment time being a treatment time during which the patient shall be submitted to blood treatment with the apparatus operating in normal mode after operation in isolated ultrafiltration mode,
a remaining patient fluid removal based on said isolated ultrafiltration volume of each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks, the remaining patient fluid removal being a volume of fluid to be extracted from the patient with the apparatus operating in normal mode after operation in isolated ultrafiltration mode,
a remaining patient fluid removal rate based on said isolated ultrafiltration rate of each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks, the remaining patient fluid removal rate being a rate of fluid to be extracted from the patient with the apparatus operating in normal mode after operation in isolated ultrafiltration mode;
wherein the control unit is configured to control the hydraulic circuit to operate in isolated ultrafiltration mode during the total treatment time corresponding to the selected plurality of isolated ultrafiltration tasks and based on the values of at the least two isolated ultrafiltration parameters received for each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks;
wherein, when the hydraulic circuit is operating in the isolated ultrafiltration mode, the control unit is further configured to control the hydraulic circuit to switch from operating in the isolated ultrafiltration mode to the normal mode upon the first of:
passage of all of said isolated ultrafiltration time;
withdrawal from a patient of said isolated ultrafiltration volume; or
receipt of a command from a user interface connected to the control unit indicating to end the isolated ultrafiltration mode;
and wherein, when operating the hydraulic circuit in the normal mode after operating in the isolated ultrafiltration mode, the control unit is configured to operate the hydraulic circuit in the normal mode based on the values of two of: the remaining treatment time, the remaining patient fluid removal, and the remaining patient fluid removal rate determined during the setup phase for each isolated ultrafiltration task of the plurality of isolated ultrafiltration tasks.

US Pat. No. 11,065,374

RENAL FAILURE THERAPY SYSTEM AND METHOD OF CLEANING USING CITRIC ACID

GAMBRO LUNDIA AB, Lund (...


1. A renal failure therapy system comprising:a dialysis fluid circuit including a dialysis fluid pump;
a source of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit;
a source of purified water in fluid communication with the dialysis fluid circuit; and
a logic implementer in operable communication with the dialysis fluid pump, wherein the logic implementer is programmed such that the system is configured to:cause the physiological cleaning, disinfecting, and/or decalcifying substance to be added from its source to purified water from the purified water source to form a mixture,
circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump to at least one of clean, disinfect, or decalcify at least a portion of the dialysis fluid circuit without a subsequent rinse after circulating and moving directly to a drain sequence,
cause a portion of the mixture to be drained in the drain sequence, wherein draining a portion of the mixture from the dialysis fluid circuit includes trapping air in the dialysis fluid circuit, and

cause a filling procedure for a second treatment to begin with a portion of the mixture remaining in the dialysis fluid circuit, wherein the filling procedure reduces the remaining mixture to a lower level and removes a portion of the remaining mixture to drain.

US Pat. No. 11,045,635

MALE FLUID CONNECTOR, A FEMALE FLUID CONNECTOR AND A FLUID CONNECTION SYSTEM COMPRISING THE SAME

Gambro Lundia AB, Lund (...


1. A male single channel fluid connector for a medical application, the male single channel fluid connector comprising:a male connector body defining a hollow male portion, wherein the male connector body has a first structure exterior of the hollow male portion allowing rotational engagement of the male connector body with a female single channel fluid connector of a first type that is a female luer connector with a hollow female portion in order to form a fluid tight connection, but preventing any engagement with a female single channel fluid connector of a second type with a hollow female portion corresponding to the hollow female portion of the female single channel fluid connector of the first type, the female single channel fluid connector of the second type also having a second structure exterior of the hollow female portion, wherein the first structure is constructed and arranged to at least partially cross-sectionally overlap the second structure when the male single channel fluid connector and the female single channel fluid connector of the second type are aligned along a common center line such that any engagement is prevented.

US Pat. No. 11,020,517

TREATMENT SOLUTION DELIVERY IN AN EXTRACORPOREAL BLOOD TREATMENT APPARATUS

Gambro Lundia AB, Lund (...

1. A method of controlling treatment solution flow in a blood treatment apparatus, wherein the blood treatment apparatus comprises:a blood circuit that includes an arterial line intended to draw blood from a patient and a venous line intended to return blood to the patient;
a filter, having a primary chamber and a secondary chamber separated by a semi- permeable membrane; and
a drain line exiting the secondary chamber to remove spent dialysate from the secondary chamber;the method comprising:filling a first intermediate container with treatment solution by delivering treatment solution from a treatment solution source to the first intermediate container, weighing the first intermediate container to determine when the amount of treatment solution in the first intermediate container has risen to a selected fill level, and halting the delivery of treatment solution to the first intermediate container when the amount of treatment solution in the first intermediate container has risen to the selected fill level;
delivering treatment solution from a second intermediate container to an output controller while filling the first intermediate container from the treatment solution source, weighing the second intermediate container to determine when the amount of treatment solution in the second intermediate container has fallen to a selected refill level, and halting the delivery of treatment solution to the output controller when the amount of treatment solution in the second intermediate container has fallen to the selected refill level;
driving the output controller to deliver treatment solution to at least one of the secondary chamber and the blood circuit through a treatment solution port; and
passing treatment solution delivered to the treatment solution port from the treatment solution source through a sterilizing filter.

US Pat. No. 11,020,518

APPARATUS AND A METHOD FOR EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. A method of controlling an apparatus for extracorporeal blood treatment, wherein the apparatus comprises a blood treatment device having a blood chamber and a fluid chamber separated from one another by a semipermeable membrane, an extracorporeal blood circuit connected to the blood chamber configured to transport blood from an individual to the blood chamber and to return the blood from the blood chamber to the individual, a blood volume sensor configured to provide a signal corresponding to an indicative value of a blood volume variation of an individual undergoing extracorporeal blood treatment using the apparatus, a sensor configured to emit at least a signal corresponding to a weight loss variation of the individual undergoing the extracorporeal blood treatment; a weight loss system configured for actuating the weight loss of the individual during the extracorporeal blood treatment;wherein the method comprises:
receiving the signal corresponding to the weight loss variation of the individual;
receiving the indicative value of the blood volume variation of the individual;
acquiring a desired value of a refilling index (IRDES), the refilling index being a function of an ability of the individual to absorb a mass of liquid subtracted from the plasmatic part of the blood by the weight loss system from cells of tissues of the individual, wherein the refilling index (IR) is defined by function (I) of a ratio between the blood volume variation (?BV) and the weight loss variation (?WL):

determining a calculated value of the refilling index (IRCAL) as a function of the blood volume variation and a weight loss variation of the individual; and
controlling the weight loss system on a basis of the desired value of the refilling index (IRDES) and the calculated value of the refilling index (IRCAL).

US Pat. No. 10,980,431

APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE

GAMBRO LUNDIA AB, Lund (...

1. A blood treatment device comprising:an extracorporeal blood flow circuit configured to be coupled to a cardiovascular system of a subject;
at least one pressure sensor configured to generate measurement data based on pressure present within the extracorporeal blood flow circuit; and
a monitoring device for predicting rapid symptomatic blood pressure decrease during the subject's blood treatment, the monitoring device including:
an input for receiving the measurement data from the at least one pressure sensor in the extracorporeal blood flow circuit configured to be coupled to the cardiovascular system of the subject, the measurement data comprising a time sequence of pulse shape parameters representing pressure variations in at least one blood vessel of the subject; and
a data analysis part configured to repeatedly receive the pulse shape parameters, calculate a pulse measure representing an overall magnitude determined by averaging a plurality of magnitudes from a plurality of the pulse shape parameters within a time window, and cause an output signal to be generated when the pulse measure fulfils a decision criterion, the output signal indicating a predicted rapid symptomatic blood pressure decrease in the subject,
wherein, when the pulse measure fulfils the decision criterion, the output signal causes the blood treatment device to (i) issue an alarm indicating that a treatment parameter of the subject's blood treatment should be adjusted, and (ii) adjust the treatment parameter of the subject's blood treatment.

US Pat. No. 10,926,018

RENAL FAILURE THERAPY SYSTEM AND METHOD FOR ELECTRICALLY SAFE TREATMENT

Gambro Lundia AB, Lund (...

1. A renal failure therapy system comprising:a dialyzer;
a blood circuit in fluid communication with the dialyzer;
a dialysis fluid circuit in fluid communication with the dialyzer;
a housing supporting the dialyzer, the blood circuit and the dialysis fluid circuit; and
at least one electrical socket held by the housing, the electrical socket providing a voltage output dedicated to a voltage of an external electrical device for powering or charging the external electrical device, the at least one electrical socket including electrical insulation for protecting a patient while powering the external electrical device,
wherein an electrically floating fluid pathway is provided in at least a portion of the blood circuit and at least a portion of the dialysis fluid circuit, and wherein the only electrical path to ground is via used dialysis fluid traveling through the dialysis fluid circuit to electrical earth.

US Pat. No. 10,918,776

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD INCLUDING CALCULATION OF FLOW RATES THEREFORE

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal treatment of blood comprising:a filtration unit including a primary chamber and a secondary chamber separated by a semi-permeable membrane;
a blood withdrawal line in fluid communication with an inlet of the primary chamber;
a blood return line in fluid communication with an outlet of the primary chamber, said blood withdrawal and return lines configured to connect to a patient;
a blood pump configured to pump blood through at least one of the blood lines;
an effluent fluid line in fluid communication with an outlet of the secondary chamber;
at least two further fluid lines selected from a group including
a pre-dilution infusion fluid line in fluid communication with the blood withdrawal line,
a post-dilution infusion fluid line in fluid communication with the blood return line,
a dialysis fluid line in fluid communication with an inlet of the secondary chamber, and
a pre-blood pump infusion fluid line in fluid communication with the blood withdrawal line at a location upstream of the blood pump;
a plurality of fluid pumps configured to pump fluid through said fluid lines; and
a control unit operably connected to said pumps and to a memory, the control unit configured to:
enter in the memory a set value for at least a first fluid flow rate selected from a group of fluid flow rates including
a fluid flow rate Qrep1 through the pre-dilution infusion fluid line,
a fluid flow rate Qrep2 through the post-dilution infusion fluid line,
a fluid flow rate Qpbp through the pre-blood pump infusion fluid line,
a fluid flow rate Qdial through the dialysis fluid line, and
a fluid removal rate Qpfr from the patient,
enter in the memory a set value for a prescribed dose Dset to be delivered,
calculate set values of at least a second and a third of the fluid flow rates of said group of fluid flow rates, based on
said set value for at least a first fluid flow rate entered in the memory,
said prescribed dose value Dset, and
a fluid balance equation establishing that a sum of the fluid flow rates through said pre-dilution infusion fluid line, post-dilution infusion fluid line, dialysis fluid line, and pre-blood pump infusion fluid line shall be equal to a fluid flow rate through the effluent fluid line Qeff,
control one or more of said fluid pumps based on the calculated set values of the fluid flow rates,
verify if a fluid flow rate has been set for at least one of the pre-dilution infusion fluid line or the pre-blood pump infusion fluid line,
calculate a correction factor Fdilution based on the fluid flow rate set for at least one of the pre-dilution infusion fluid line or the pre-blood pump infusion fluid line, and
correct the convective dose flow rate value Dconv_set to account for the effect of pre-dilution based on said correction factor,
wherein said prescribed dose value Dset is a convective dose flow rate value Dconv_set, which is a prescribed mean value of the sum of the fluid flow rates through all infusion fluid lines Qrep1, Qrep2, Qpbp and the patient fluid removal rate Qpfr,
wherein the control unit is configured to correct the convective dose flow rate value to account for the effect of pre-dilution based on said correction factor using the following formula:
Dcorr_conv_set=Fdilution×Dconv_set, where
Fdilution is the correction factor,
Dconv_set is the prescribed mean value of the sum of the fluid flow rates through all infusion fluid lines Qrep1, Qrep2, Qpbp and the patient fluid removal rate Qom, and
Dcorr_conv_set is a corrected convective dose flow rate value, and
wherein the correction factor Fdilution is defined according to one of the following:
a blood dilution factor,
Fdilutionblood=Qblood/Qblood+Qpre,
a plasma dilution factor,
Fdilutionplasma=Qp/Qp+Qpre=(1?Hct)×Qblood/(1?Hct)×Qblood+Qpre, or
a plasma water dilution factor,
Fdilutionpw=Qpw/Qpw+Qpre=(1?Hct)×Fp×Qblood/(1?Hct)×Fp×Qblood+Qpre,
where
Qpre is total a pre-dilution infusion rate set for the pre-dilution infusion fluid line and the pre-blood pump infusion fluid line,
Qblood is a blood flow rate,
Qp is a plasma flow rate,
Qpw is a plasma water flow rate,
Hct is the haematocrit, and
Fp is a plasma water fraction, which is a function of total protein concentration.

US Pat. No. 10,835,868

FILTER DEVICE, SYSTEM AND METHOD FOR FILTRATION OF FLUIDS

GAMBRO LUNDIA AB, Lund (...

1. System for filtration of fluids, comprising a filter device for filtration of fluids, wherein the filter device comprises:a housing having a first end and a second end and defining a fluid chamber extending between the first end and the second end;
a first lid provided at the first end of the housing and comprising a first fluid port, a first compartment, a second compartment and a first internal separating wall separating the first compartment from the second compartment;
a second lid provided at the second end of the housing and comprising a second fluid port, a third fluid port, a third compartment, a fourth compartment and a second internal separating wall separating the third compartment from the fourth compartment;
a plurality of hollow fibers arranged within the housing, wherein each of the plurality of hollow fibers comprises a semi-permeable membrane and defines a fluid channel extending longitudinally through an interior of the respective hollow fiber;
a first sealing means which separates the fluid chamber from the first and the second compartment, the first sealing means having a first longitudinal end facing away from the second lid;
a second sealing means which separates the fluid chamber from the third and the fourth compartment, the second sealing means having a second longitudinal end facing away from the first lid; and
a fourth fluid port and a fifth fluid port both provided at the fluid chamber and located between the first longitudinal end of the first sealing means and the second longitudinal end of the second sealing means;
wherein the first fluid port is arranged at the first compartment, wherein the second fluid port is arranged at the third compartment, wherein the third fluid port is arranged at the fourth compartment,
wherein the plurality of hollow fibers comprise a first group of fibers and a second group of fibers, wherein each hollow fiber of the first group of fibers extends from the first compartment through the fluid chamber to the third compartment and fluidly connects the first compartment with the third compartment via the fluid channels extending through the interior of each hollow fiber of the first group of fibers, and wherein each hollow fiber of the second group of fibers extends from the second compartment through the fluid chamber to the fourth compartment and fluidly connects the second compartment with the fourth compartment via the fluid channels extending through the interior of each hollow fiber of the second group of fibers,
wherein the fourth and the fifth fluid port are fluidly connected to one another and both in fluidic communication with an exterior of both the hollow fibers of the first and the second group of fibers via the fluid chamber,
and wherein the system further comprises a substitution fluid line which is configured to be switchable between a pre-dilution mode, in which the third fluid port is fluidly connected to the first fluid port of the filter device, and a post-dilution mode, in which the third fluid port is fluidly connected to the second fluid port of the filter device, the substitution fluid line being arranged outside the housing of the filter device.

US Pat. No. 10,786,613

APPARATUS AND METHOD FOR DETERMINING A PARAMETER INDICATIVE OF THE PROGRESS OF AN EXTRACORPOREAL BLOOD TREATMENT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal treatment of blood comprising:a preparation line having one end configured for being connected to an inlet of a secondary chamber of a treatment unit, a semi-permeable membrane separating said secondary chamber from a primary chamber of the same treatment unit;
a spent dialysate line having one end configured for being connected to an outlet of said secondary chamber; and
a control unit configured for commanding execution of the following steps:
causing a fresh treatment liquid to flow in the preparation line towards the secondary chamber at a flow rate, the treatment liquid including lactate;
causing a used treatment liquid to flow in the spent dialysate line at a flow rate;
receiving one or more measured values of a parameter related to the concentration of lactate in the used treatment liquid flowing in the spent dialysate line; and
computing at least one value of a parameter indicative of the effectiveness of the extracorporeal blood treatment based on:
said one or more measured values of the parameter related to the concentration of lactate of the used treatment liquid; and
at least one of: said flow rate of fresh treatment liquid and said flow rate of used treatment liquid.

US Pat. No. 11,116,067

RENAL FAILURE THERAPY SYSTEM HAVING ELECTRICALLY FLOATING FLUID PATHWAY

Gambro Lundia AB, Lund (...


1. A renal failure therapy system comprising:a dialyzer;
a blood circuit in fluid communication with the dialyzer;
a dialysis fluid circuit in fluid communication with the dialyzer; and
an electrically floating fluid pathway comprising at least a portion of the blood circuit and at least a portion of the dialysis fluid circuit, wherein the only electrical path to ground is via used dialysis fluid traveling through the renal failure therapy system to earth ground,
wherein at least one electrical component in the at least a portion of the dialysis fluid circuit of the electrically floating fluid pathway is electrically bypassed, and
wherein the at least a portion of the dialysis fluid circuit includes at least a portion of a fresh dialysis fluid line and at least a portion of a used dialysis fluid line.

US Pat. No. 11,060,516

PERISTALTIC PUMP TUBE

GAMBRO LUNDIA AB, Lund (...


1. A tube for a peristaltic pump, comprising:an elastically deformable tubular body, the tubular body made from a material containing a blend of at least:(i) a vinyl chloride resin having a K value of not less than 85 and no more than 105 measured according to standard ISO 1628-2; and
(ii) a plasticizer comprising an ester of adipic acid;

the tubular body being made entirely of a single layer of the material.

US Pat. No. 11,058,810

DETECTION OF A DISRUPTION OF A FLUID CONNECTION BETWEEN TWO FLUID CONTAINING SYSTEMS

GAMBRO LUNDIA AB, Lund (...


1. A monitoring device, comprising:an input interface for receiving one or more measurement signals from one or more sensors arranged in or associated with a first fluid containing system and/or a second fluid containing system, the one or more measurement signals being responsive to a disruption of a fluid connection between the first fluid containing system and the second fluid containing system,
a first disruption detector and a second disruption detector, each being configured to operate a respective detection logic on at least one of the one or more measurement signals to detect apparent disruptions of the fluid connection and provide alarm indications corresponding to the apparent disruptions,
an alarm module for generating an alarm signal based on the alarm indications, and
a switching module configured to operate the monitoring device in one of a first mode, in which at least the first disruption detector is operated and the alarm signal is generated based only on the alarm indications provided by the first disruption detector, and a second mode, in which at least the second disruption detector is operated and the alarm signal is based at least on the alarm indications provided by the second disruption detector,
wherein the switching module is configured to, when operating the monitoring device in the first mode, obtain at least one of a first count of false alarm indications provided per unit time by the first disruption detector and a second count of false alarm indications provided per unit time by the second disruption detector, and selectively, based on at least one of the first and second counts, switch the monitoring device to the second mode.

US Pat. No. 10,993,961

DIALYSIS PRECURSOR COMPOSITION

Gambro Lundia AB, Lund (...

1. A dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution, the dialysis acid precursor composition comprising:powder components comprising a sodium chloride powder, at least one dry acid powder, at least one magnesium salt powder, at least one calcium salt powder selected from the group consisting of calcium chloride monohydrate, anhydrous calcium chloride, calcium gluconate, and calcium ?-ketoglutarate, and a glucose powder,
wherein the at least one magnesium salt powder is in a quantity such that a concentration of 7.5-50 mM magnesium ions is provided in the dialysis acid concentrate solution, wherein the at least one magnesium salt and the glucose are present as anhydrous components in the dialysis acid precursor composition, wherein at least one of the sodium chloride, the at least one dry acid, or the at least one calcium salt is present as a non-anhydrous component, and wherein the dialysis acid precursor composition is sealed in a moisture-resistant container with a water vapor transmission rate less than 0.3 g/m2/d at 38° C./90% RH, and
wherein the dialysis acid precursor composition does not comprise acetic acid or acetate, and does not comprise lactic acid or lactate.